WorldWideScience

Sample records for preliminary sensitivity testing

  1. Contact sensitization in venous eczema: Preliminary results of patch testing with Indian standard series and topical medicaments

    Directory of Open Access Journals (Sweden)

    Jindal Rashmi

    2009-01-01

    Full Text Available Background and Aims: Elimination of allergens/topical medications causing contact dermatitis in venous eczema, which poses a significant problem in its chronicity and treatment, provides the basis for better therapeutic outcome. Our objective was to determine the pattern of contact sensitization in venous eczema patients in Himachal Pradesh (India. Methods: Thirty-four patients (M:F, 31:3 and 10 controls (M:F, 6:4 were patch tested with Indian standard series and 10 commonly used topical medicaments. Results: Positive patch test results were seen in 50% (M:F, 16:1 of the patients. Common allergens were Fragrance mix (15%, p-phenylendiamine (15%, nickel (9%, wool alcohol (9%, chinoform (9%, balsum of Peru (5%, cobalt chloride (5%, potassium dichromate (3%, epoxy resin (3%, thiuram mix (3% and formaldehyde (3%. Only sisomycin and miconazole among the topical medications elicited a positive patch test reaction in 3 and 5% patients, respectively. Neomycin contact sensitivity was not seen in any of the patients. One patient who had exacerbation of venous eczema following accidental application of topical diclofenac showed a positive patch test reaction to it. Conclusions: Patch test should be used to identify the topical agents that may be responsible for perpetuation or aggravation of eczema, especially in patients who do not improve despite adequate treatment of other underlying cause(s.

  2. Preliminary assessment of terrestrial microalgae isolated from lichens as testing species for environmental monitoring: lichen phycobionts present high sensitivity to environmental micropollutants.

    Science.gov (United States)

    Domínguez-Morueco, N; Moreno, H; Barreno, E; Catalá, M

    2014-01-01

    Bioassays constitute a tool for pollution analysis providing a holistic approach and high-quality indication of the toxicity. Microbioassays allow evaluating the toxicity of many samples, implying lower costs and enabling routine monitoring and pollution control. But tests conducted so far are limited to the use of a small number of taxa. Lichens are excellent bioindicators of pollution with great ecological significance. Studies show that the phycobiont is more sensitive to pollutants than the mycobiont. Phycobiont have features such as adaptation to anhydrobiosis and relatively rapid growth in vitro, making them suitable for microbioassays. Our aim is to determine the sensitivity of phycobionts to the pharmaceutical micropollutants carbamazepine and diclofenac as a preliminary step for the development of a toxicity microbioassay based on phycobionts. Optical dispersion and chlorophyll autofluorescence were used as endpoints of toxicity on two algal species showing that suspensions present cyclic and taxon specific patterns of aggregation. Trebouxia TR9 suspensions present a very high grade of aggregation while Asterochloris erici cells do not. Both micropollutants alter optical properties of the suspensions of both species. No significant alteration of chlorophyll autofluorescence by carbamazepine is observed. A. erici chlorophyll autofluorescence is extremely sensitive to diclofenac but the effect is not dependent on the drug concentration or on the time of exposure. Differently, TR9 only shows punctual chlorophyll alterations. Fluctuations in optical dispersion may indicate changes in the population structure of the species, including reproductive strategy. A. erici seems more sensitive to micropollutants, is better characterized and is available from commercial collections.

  3. Local Sensitivity and Diagnostic Tests

    NARCIS (Netherlands)

    Magnus, J.R.; Vasnev, A.L.

    2004-01-01

    In this paper we confront sensitivity analysis with diagnostic testing.Every model is misspecified, but a model is useful if the parameters of interest (the focus) are not sensitive to small perturbations in the underlying assumptions. The study of the e ect of these violations on the focus is calle

  4. Catechol-O-methyltransferase Val158Met genotype in healthy and personality disorder individuals: Preliminary results from an examination of cognitive tests hypothetically differentially sensitive to dopamine functions

    Directory of Open Access Journals (Sweden)

    Winnie W Leung

    2007-01-01

    Full Text Available Winnie W Leung1, Margaret M McClure1, Larry J Siever1,2, Deanna M Barch3, Philip D Harvey1,21Department of Veterans Affairs, VISN 3 Mental Illness Research, Education, and Clinical Center (MIRECC, Bronx, NY, USA; 2Department of Psychiatry, Mt. Sinai School of Medicine, New York, NY, USA; 3Departments of Psychology and Psychiatry, Washington University, St. Louis, MO, USAAbstract: A functional polymorphism of the gene coding for Catechol-O-methyltrasferase (COMT, an enzyme responsible for the degradation of the catecholamine dopamine (DA, epinephrine, and norepinephrine, is associated with cognitive deficits. However, previous studies have not examined the effects of COMT on context processing, as measured by the AX-CPT, a task hypothesized to be maximally relevant to DA function. 32 individuals who were either healthy, with schizotypal personality disorder, or non-cluster A, personality disorder (OPD were genotyped at the COMT Val158Met locus. Met/Met (n = 6, Val/Met (n = 10, Val/Val (n = 16 individuals were administered a neuropsychological battery, including the AX-CPT and the N-back working memory test. For the AX-CPT, Met/Met demonstrated more AY errors (reflecting good maintenance of context than the other genotypes, who showed equivalent error rates. Val/Val demonstrated disproportionately greater deterioration with increased task difficulty from 0-back to 1-back working memory demands as compared to Met/Met, while Val/Met did not differ from either genotypes. No differences were found on processing speed or verbal working memory. Both context processing and working memory appear related to COMT genotype and the AX-CPT and N-back may be most sensitive to the effects of COMT variation.Keywords: COMT, dopamine, context processing, working memory, schizotypal personality disorder

  5. An analysis of sensitivity tests

    Energy Technology Data Exchange (ETDEWEB)

    Neyer, B.T.

    1992-03-06

    A new method of analyzing sensitivity tests is proposed. It uses the Likelihood Ratio Test to compute regions of arbitrary confidence. It can calculate confidence regions for the parameters of the distribution (e.g., the mean, {mu}, and the standard deviation, {sigma}) as well as various percentiles. Unlike presently used methods, such as those based on asymptotic analysis, it can analyze the results of all sensitivity tests, and it does not significantly underestimate the size of the confidence regions. The main disadvantage of this method is that it requires much more computation to calculate the confidence regions. However, these calculations can be easily and quickly performed on most computers.

  6. Preliminary Results of Field Emission Cathode Tests

    Science.gov (United States)

    Sovey, James S.; Kovaleski, Scott D.

    2001-01-01

    Preliminary screening tests of field emission cathodes such as chemical vapor deposited (CVD) diamond, textured pyrolytic graphite, and textured copper were conducted at background pressures typical of electric thruster test facilities to assess cathode performance and stability. Very low power electric thrusters which provide tens to hundreds micronewtons of thrust may need field emission neutralizers that have a capability of tens to hundreds of microamperes. From current voltage characteristics, it was found that the CVD diamond and textured metals cathodes clearly satisfied the Fowler-Nordheim emission relation. The CVD diamond and a textured copper cathode had average current densities of 270 and 380 mA/sq cm, respectively, at the beginning-of-life. After a few hours of operation the cathode emission currents degraded by 40 to 75% at background pressures in the 10(exp -5) Pa to 10(exp -4) Pa range. The textured pyrolytic graphite had a modest current density at beginning-of-life of 84 mA/sq cm, but this cathode was the most stable of all. Extended testing of the most promising cathodes is warranted to determine if current degradation is a burn-in effect or whether it is a long-term degradation process. Preliminary experiments with ferroelectric emission cathodes, which are ceramics with spontaneous electric polarization, were conducted. Peak current densities of 30 to 120 mA/sq cm were obtained for pulse durations of about 500 ns in the 10(exp -4) Pa pressure range.

  7. The picture test of separation and individuation - preliminary research

    Directory of Open Access Journals (Sweden)

    Gregor Žvelc

    2000-06-01

    Full Text Available Authors introduce a new instrument, which they developed for measuring separation and individuation process and attachment in adolescence and adulthood. The Picture Test of Separation and Individuation (PTSI is a semi–projective test. It consists of various pictures, which represent relationships with significant others. PTSI is divided into three subtests: Relationship with Mother, Relationship with Father and Attachment. In a preliminary research on a sample of college and university students authors studied basic properties of the test. The results of the research indicate that PTSI is consistent with theoretical background, has good sensitivity and is economical. The Picture Test of Separation and Individuation enables quick but complex insight into individual's relationships with significant others as well as into his/her stage of separation and individuation process. Considering satisfying results of pilot study, authors suggest further research for validation of the test.

  8. Sensitivity to Pain Traumatization Scale: development, validation, and preliminary findings

    Science.gov (United States)

    Katz, Joel; Fashler, Samantha R; Wicks, Claire; Pagé, M Gabrielle; Roosen, Kaley M; Kleiman, Valery; Clarke, Hance

    2017-01-01

    Background This article reports three studies describing the development and validation of the 12-item Sensitivity to Pain Traumatization Scale (SPTS-12). SPT refers to the anxiety-related cognitive, emotional, and behavioral reactions to pain that resemble the features of a traumatic stress reaction. Methods In Study 1, a preliminary set of 79 items was administered to 116 participants. The data were analyzed by using combined nonparametric and parametric item response theory resulting in a 12-item scale with a one-factor structure and good preliminary psychometric properties. Studies 2 and 3 assessed the factor structure and psychometric properties of the SPTS-12 in a community sample of 823 participants (268 with chronic pain and 555 pain-free) and a clinical sample of 345 patients (126 with chronic post-surgical pain, 92 with other nonsurgical chronic pain, and 127 with no chronic pain) at least 6 months after undergoing coronary artery bypass graft surgery, respectively. Results The final SPTS-12 derived from Study 1 comprised 12 items that discriminated between individuals with different levels of SPT, with the overall scale showing good to very good reliability and validity. The results from Studies 2 and 3 revealed a one-factor structure for chronic pain and pain-free samples, excellent reliability and concurrent validity, and moderate convergent and discriminant validity. Conclusion The results of the three studies provide preliminary evidence for the validity and reliability of the SPTS-12. PMID:28615962

  9. Preliminary test results for the SVX4

    Energy Technology Data Exchange (ETDEWEB)

    Christofek, L.; Hanagaki, K.; Rapidis, P.; Utes, M.; /Fermilab

    2005-06-01

    We present and summarize the preliminary test results for SVX4 chip testing. There are presently two versions of the SVX4. Version 2 has on-chip bypassing and Version 1 does not. The on-chip bypassing is a layer of transistors under the front-end analog pipeline that acts as a bypassing capacitor for the voltage supply. Its size is about a microfarad. We aggressively choose to test Version 2 because of this feature. The feature is advantageous for hybrid design because it eliminates the need for an additional passive component on the hybrid itself by placing it on the actual SVX4 die. Also, the SVX4 was designed to operate in two modes: D. and CDF. One can set which mode the chip will operate by placing a jumper in the proper position on the SVX4 chip carrier. In either mode, the chip can either use the operating parameters from the shift register or the shadow register. Similarly, this is selected by placing a jumper on the SVX4 chip carrier. This chip has this feature because it was unknown whether the new design of the shadow register would be operable. The shadow register is also call the SEU register or Single Event Upset register. An introduction into the functionality of the chip and an explanation on the difference between D. and CDF mode can be found in the SVX4 User's Manual [1].

  10. Preliminary results of steel containment vessel model test

    Energy Technology Data Exchange (ETDEWEB)

    Luk, V.K.; Hessheimer, M.F. [Sandia National Labs., Albuquerque, NM (United States); Matsumoto, T.; Komine, K.; Arai, S. [Nuclear Power Engineering Corp., Tokyo (Japan); Costello, J.F. [Nuclear Regulatory Commission, Washington, DC (United States)

    1998-04-01

    A high pressure test of a mixed-scaled model (1:10 in geometry and 1:4 in shell thickness) of a steel containment vessel (SCV), representing an improved boiling water reactor (BWR) Mark II containment, was conducted on December 11--12, 1996 at Sandia National Laboratories. This paper describes the preliminary results of the high pressure test. In addition, the preliminary post-test measurement data and the preliminary comparison of test data with pretest analysis predictions are also presented.

  11. Sensitive neutralization test for rubella antibody.

    Science.gov (United States)

    Sato, H; Albrecht, P; Krugman, S; Ennis, F A

    1979-01-01

    A modified rubella virus plaque neutralization test for measuring rubella antibody was developed based on the potentiation of the virus-antibody complex by heterologous anti-immunoglobulin. The test is highly sensitive, yielding titers on the average 50 to 100 times higher than the haemagglutination inhibition test or the conventional plaque neutralization test. The sensitivity of this enhanced neutralization test is somewhat limited by the existence of a prozone phenomenon which precludes testing of low-titered sera below a dilution of 1:16. No prozone effect was observed with cerebrospinal fluids. The specificity of the enhanced neutralization test was determined by seroconversion of individuals receiving rubella vaccine. Although the rubella hemagglutination inhibition test remains the test of choice in routine diagnostic and surveillance work, the enhanced rubella neutralization test is particularly useful in monitoring low-level antibody in the cerebrospinal fluid in patients with neurological disorders and in certain instances of vaccine failure. PMID:107192

  12. Component resolved testing for allergic sensitization

    DEFF Research Database (Denmark)

    Skamstrup Hansen, Kirsten; Poulsen, Lars K

    2010-01-01

    Component resolved diagnostics introduces new possibilities regarding diagnosis of allergic diseases and individualized, allergen-specific treatment. Furthermore, refinement of IgE-based testing may help elucidate the correlation or lack of correlation between allergenic sensitization and allergi...

  13. Parametric Sensitivity Tests- European PEM Fuel Cell Stack Test Procedures

    DEFF Research Database (Denmark)

    Araya, Samuel Simon; Andreasen, Søren Juhl; Kær, Søren Knudsen

    2014-01-01

    As fuel cells are increasingly commercialized for various applications, harmonized and industry-relevant test procedures are necessary to benchmark tests and to ensure comparability of stack performance results from different parties. This paper reports the results of parametric sensitivity tests...... performed based on test procedures proposed by a European project, Stack-Test. The sensitivity of a Nafion-based low temperature PEMFC stack’s performance to parametric changes was the main objective of the tests. Four crucial parameters for fuel cell operation were chosen; relative humidity, temperature...

  14. 75 FR 8925 - Pressure Sensitive Plastic Tape from Italy: Preliminary Results of Antidumping Duty Changed...

    Science.gov (United States)

    2010-02-26

    ... International Trade Administration Pressure Sensitive Plastic Tape from Italy: Preliminary Results of... pressure sensitive plastic tape from Italy pursuant to section 751(b) of the Tariff Act of 1930, as amended... review request. See Pressure Sensitive Plastic Tape from Italy: Notice of Initiation of Antidumping...

  15. Testing the Preliminary X-33 Navigation System

    Science.gov (United States)

    Lomas, James J.; Mitchell, Daniel W.; Freestone, Todd M.; Lee, Charles; Lessman, Craig; Foster, Lee D. (Technical Monitor)

    2001-01-01

    The X-33 Reusable Launch Vehicle (RLV) must meet the demanding requirements of landing autonomously on a narrow landing strip following a flight that reaches an altitude of up to 200,000 feet and a speed in excess of Mach 9 with significant in-flight energy bleed-off maneuvers. To execute this flight regimen a highly reliable avionics system has been designed that includes three LN-100G Inertial Navigation System/Global Positioning System (INS/GPS) units as the primary navigation system for the X-33. NASA's Marshall Space Flight Center (MSFC) tested an INS/GPS system in real-time simulations to determine the ability of this navigation suite to meet the in flight and autonomous landing requirements of the X-33 RLV. A total of sixty-one open loop tests were performed to characterize the navigation accuracy of the LN-100G. Twenty-seven closed-loop tests were also performed to evaluate the performance of the X-33 Guidance, Navigation and Control (GN&C) algorithms with the real navigation hardware. These closed-loop tests were also designed to expose any integration or operational issues with the real-time X-33 vehicle simulation. Dynamic road tests of the INS/GPS were conducted by Litton to assess the performance of differential and nondifferential INS/GPS hybrid navigation solutions. The results of the simulations and road testing demonstrate that this novel solution is capable of meeting the demanding requirements of take-off, in-flight navigation, and autonomous landing of the X-33 RLV. This paper describes the test environment developed to stimulate the LN-100G and discusses the results of this test effort. This paper also presents recommendations for a navigation system suitable to an operational RLV system.

  16. Platform for dynamic tests: preliminary studies, design and construction

    Directory of Open Access Journals (Sweden)

    J. E. Campuzano

    Full Text Available This paper is about the design and construction of a platform for dynamic tests especially with people jumping, walking, etc. Initially it was tried to find out projects already implemented in platforms and dynamic tests and to study the loads produced by movement of people on slabs and the structural response to these loads. The limits established by different standards have been also studied for these dynamic responses, taking into account the ultimate limit state, as well as the structure in service, since the human body is very sensitive to structural vibrations. Parametric studies were performed considering various configurations of slabs (different spans, thicknesses and conditions of support have been done, looking for a configuration that could have natural frequency close to the frequencies of the human loads. The slab should have dimensions compatible with the available physical space, fundamental frequency below 5 Hz and maximum immediate deflection compatible with the indications of the Brazilian standard NBR6118: 2007. Based on these criteria was chosen a rectangular structure consists of a solid reinforced concrete rectangular slab studded in two opposite edges of steel beams with shear connectors type U. The other two edges are free. The steel beams supporting the slab, in turn, are supported on eight metal profiles (two in each corner of the slab that are supported on two to two short columns of steel profile H. Profiles U in steel are welded to four columns, forming a horizontal frame. Numerical analysis of the dynamic test platform have been performed for free and forced vibration, for obtaining the natural frequencies and corresponding vibration modes, considering the self-weight of the structure and the load that simulates people's weight. After obtaining a structural configuration that fulfilled the stipulated requirements, the design of the slab taking into account the recommendations of the Brazilian standard NBR6118: 2007

  17. Component resolved testing for allergic sensitization

    DEFF Research Database (Denmark)

    Skamstrup Hansen, Kirsten; Poulsen, Lars K

    2010-01-01

    disease. Novel tools to predict severe outcomes and to plan for allergen-specific treatment are necessary, and because only a small amount of blood is needed to test for a multitude of allergens and allergenic components, component resolved diagnostics is promising. A drawback is the risk of overdiagnosis......Component resolved diagnostics introduces new possibilities regarding diagnosis of allergic diseases and individualized, allergen-specific treatment. Furthermore, refinement of IgE-based testing may help elucidate the correlation or lack of correlation between allergenic sensitization and allergic...... and misinterpretation of the complex results of such tests. Also, the practical use and selection of allergenic components need to be evaluated in large studies including well-characterized patients and healthy, sensitized controls and with representation of different geographical regions....

  18. Deployment of a Pressure Sensitive Paint System for Measuring Global Surface Pressures on Rotorcraft Blades in Simulated Forward Flight: Preliminary PSP Results from Test 581 in the 14- by 22-Foot Subsonic Tunnel

    Science.gov (United States)

    Watkins, Anthony Neal; Leighty, Bradley D.; Lipford, William E.; Wong, Oliver D.; Goodman, Kyle Z.; Crafton, James; Forlines, Alan; Goss, Larry; Gregory, James W.; Juliano, Thomas J.

    2011-01-01

    This report will present details of a Pressure Sensitive Paint (PSP) system for measuring global surface pressures on the tips of rotorcraft blades in simulated forward flight at the 14- x 22-Foot Subsonic Tunnel. The system was designed to use a pulsed laser as an excitation source and PSP data was collected using the lifetime-based approach. With the higher intensity of the laser, this allowed PSP images to be acquired during a single laser pulse, resulting in the collection of crisp images that can be used to determine blade pressure at a specific instant in time. This is extremely important in rotorcraft applications as the blades experience dramatically different flow fields depending on their position in the rotor disk. Testing of the system was performed using the U.S. Army General Rotor Model System equipped with four identical blades. Two of the blades were instrumented with pressure transducers to allow for comparison of the results obtained from the PSP. This report will also detail possible improvements to the system.

  19. Preliminary Test for Nonlinear Input Output Relations in SISO Systems

    DEFF Research Database (Denmark)

    Knudsen, Torben

    2000-01-01

    This paper discusses and develops preliminary statistical tests for detecting nonlinearities in the deterministic part of SISO systems with noise. The most referenced method is unreliable for common noise processes as e.g.\\ colored. Therefore two new methods based on superposition and sinus input...

  20. The picture test of separation and individuation - preliminary research

    OpenAIRE

    Gregor Žvelc; Maša Žvelc

    2000-01-01

    Authors introduce a new instrument, which they developed for measuring separation and individuation process and attachment in adolescence and adulthood. The Picture Test of Separation and Individuation (PTSI) is a semi–projective test. It consists of various pictures, which represent relationships with significant others. PTSI is divided into three subtests: Relationship with Mother, Relationship with Father and Attachment. In a preliminary research on a sample of college and university...

  1. Preliminary Studies on X-Ray-sensitive Liposome

    Institute of Scientific and Technical Information of China (English)

    MENG Fan-xu; XU Hua-ping; QI Yan-fei; XU Kun; SONG Xiu-ling; NIU Shu; LI Juan

    2012-01-01

    The synthesis of a new type of X-ray-sensitive compound “di-(1-hydroxylundecyl)diselenide” and its application in the preparation of a new type of liposome with X-ray sensitivity was reported.This new liposome was synthesized to encapsulate doxorubicin hydrochloride(Dox),with its physical and chemical properties,stability,and radiation sensitivity determined.Based on the pH-gradient method,liposomal Dox was prepared via ultrasonic emulsification and then purified on a Sephadex G50 mini-column.UV spectrophotometry and liquid chromatography were used to detect the encapsulation efficiency and radiation sensitivity of the Dox-loaded liposome.The results show that through changes in release rate,this liposome shows a relative radiosensitivity.In terms of radiation sensitivity,the drug leak rate of the X-ray-sensitive Dox-loaded liposome increased gradually and peaked at 65.4% under the X-ray radiation of a dose of 10 Gy or more than 10 Gy,which is significantly different from that of ordinary liposomes.Meanwhile,X-ray-sensitive Dox-loaded liposome has a good dispersion stability,with an average particle size of approximate 120 nm.The efficiency of this liposome encapsulating Dox was 75.84%,slightly lower than that of ordinary liposomes.The X-ray-sensitive Dox-loaded liposome exhibited suspension stability within 30 d of storage at 4 ℃,without visible precipitation.Di-(1-hydroxylundecyl)diselenide is safe and noncytotoxic and compared with those of synthetic phospholipids its synthesis is low cost and does not require complex conditions.

  2. Definition study for an extended manned test of a regenerative life support system, preliminary test plan

    Science.gov (United States)

    1971-01-01

    A preliminary plan and procedure are presented for conducting an extended manned test program for a regenerative life support system. Emphasis will be placed on elements associated with long-term system operation and long-term uninterrupted crew confinement.

  3. Reinforcement Sensitivity and Responsiveness to Performance Feedback: A Preliminary Investigation

    Science.gov (United States)

    Lovett, Benjamin J.; Eckert, Tanya L.

    2009-01-01

    Variability in responsiveness to academic interventions is a common phenomenon in school psychology practice, but the variables associated with this responsiveness are not well understood. Reinforcement sensitivity, a generalized tendency to learn quickly in reward contingency situations, is one variable for increased understanding. In the present…

  4. Reinforcement Sensitivity and Responsiveness to Performance Feedback: A Preliminary Investigation

    Science.gov (United States)

    Lovett, Benjamin J.; Eckert, Tanya L.

    2009-01-01

    Variability in responsiveness to academic interventions is a common phenomenon in school psychology practice, but the variables associated with this responsiveness are not well understood. Reinforcement sensitivity, a generalized tendency to learn quickly in reward contingency situations, is one variable for increased understanding. In the present…

  5. Echinodermata in ecotoxicological tests: maintenance and sensitivity

    Directory of Open Access Journals (Sweden)

    Jocássio Batista Soares

    2016-03-01

    Full Text Available Abstract This work investigates the sensitivity of four species of Echinodermata (Lytechinus variegatus, Echinometra lucunter, Arbacia lixula and Encope emarginata, evaluating the effect of five reference toxicants (Cd, Pb, Cr, Cu and SDS on embryo-larval development, following the official protocols. It also evaluates techniques for the maintenance of L. variegatus in the laboratory, changes in its sensitivity, and the effects of chemical agents that induce the release of gametes, on the survival rates of the organisms. In terms of the maintenance of L. variegatus in the laboratory, the diet with vegetable content appears to be more favorable for maintenance and maturation in cultivation tanks. Chemical inducers such as KCl and the Anesthetic (lidocaine and epinephrine resulted in high adult mortality rates, discouraging its re-induction. The tests performed with different species of sea urchin and sand dollar, using different reference toxicants, showed no variations in sensitivity to the more toxic chemicals, indicating that different species can be used for evaluation and environmental impact assessment.

  6. Prevention of postoperative tooth sensitivity: a preliminary clinical trial.

    Science.gov (United States)

    Sobral, M A P; Garone-Netto, N; Luz, M A A C; Santos, A P

    2005-09-01

    The purpose of this study was to evaluate clinically the effects of pre-treatments with a 35% hydroxyethyl metacrylate/5% glutaraldehyde dentine desensitizer (Gluma Desensitizer) and a 2% chlorexidine-based cavity disinfectant (Cav-Clean) on postoperative sensitivity. Three premolar teeth with no pain symptoms were selected from each one of 17 patients, totalling 51 teeth, for which Class II restoration using a composite was indicated. Each one of the three premolar teeth of the same patient was submitted to a different treatment. After acid etching, only a dental adhesive was applied to the first tooth, which served as the control. Gluma Desensitizer dentinal desensitizer was applied to the second premolar tooth prior to applying the dental adhesive. Cav-Clean cavity disinfectant was used on the third premolar tooth before applying the dental adhesive. Only one tooth was restored per session, and all premolar teeth were restored with a condensable composite, according to current restoration technique guidelines. Sensitivity to different stimuli (cold, heat, sweet and dental floss) was assessed on Day 1, Day 4 and Day 7 by questionnaire following restorative procedures. The results of this clinical research showed that, as far as the investigated stimuli and postoperative course are concerned, there was no statistically significant difference in the three different treatments (P>0.05). Postoperative sensitivity resulting from Class II restorations using composite resin cannot be completely eliminated with the prior use of a dentinal desensitizer or a cavity disinfectant. In day-to-day clinical treatment, postoperative sensitivity may possibly be related to the technique employed.

  7. Modeling and Testing of EVs - Preliminary Study and Laboratory Development

    DEFF Research Database (Denmark)

    Yang, Guang-Ya; Marra, Francesco; Nielsen, Arne Hejde

    2010-01-01

    impact at different geographical areas, as well as driving and charging patterns. Electric circuit model is deployed in this work to represent the electrical properties of a lithium-ion battery. This paper reports the preliminary modeling and validation work based on manufacturer data sheet and realistic......Electric vehicles (EVs) are expected to play a key role in the future energy management system to stabilize both supply and consumption with the presence of high penetration of renewable generation. A reasonably accurate model of battery is a key element for the study of EVs behavior and the grid...... tests, followed by the suggestions towards a feasible battery model for further studies....

  8. Design and preliminary testing of the RIC hybrid knee prosthesis.

    Science.gov (United States)

    Lenzi, T; Sensinger, J; Lipsey, J; Hargrove, L; Kuiken, T

    2015-08-01

    We present a novel hybrid knee prosthesis that uses a motor, transmission and control system only for active dynamics tasks, while relying on a spring/damper system for passive dynamics activities. Active dynamics tasks require higher torque, lower speed, and occur less frequently than passive dynamic activities. By designing the actuation system around active tasks alone, we achieved a lightweight design (1.7 Kg w/o battery) without sacrificing peak torque (85Nm repetitive). Preliminary tests performed by an able-bodied person using a bypass orthosis show that the hybrid knee can support reciprocal stairs ambulation with low electrical energy consumption.

  9. Preliminary Design of a LSA Aircraft Using Wind Tunnel Tests

    Directory of Open Access Journals (Sweden)

    Norbert ANGI

    2015-12-01

    Full Text Available This paper presents preliminary results concerning the design and aerodynamic calculations of a light sport aircraft (LSA. These were performed for a new lightweight, low cost, low fuel consumption and long-range aircraft. The design process was based on specific software tools as Advanced Aircraft Analysis (AAA, XFlr 5 aerodynamic and dynamic stability analysis, and Catia design, according to CS-LSA requirements. The calculations were accomplished by a series of tests performed in the wind tunnel in order to assess experimentally the aerodynamic characteristics of the airplane.

  10. Preliminary wind tunnel tests on the pedal wind turbine

    Science.gov (United States)

    Vinayagalingam, T.

    1980-06-01

    High solidity-low speed wind turbines are relatively simple to construct and can be used advantageously in many developing countries for such direct applications as water pumping. Established designs in this class, such as the Savonius and the American multiblade rotors, have the disadvantage that their moving surfaces require a rigid construction, thereby rendering large units uneconomical. In this respect, the pedal wind turbine recently reported by the author and which incorporates sail type rotors offers a number of advantages. This note reports preliminary results from a series of wind tunnel tests which were carried out to assess the aerodynamic torque and power characteristics of the turbine.

  11. Preliminary Feasibility Testing of the BRIC Brine Water Recovery Concept

    Science.gov (United States)

    Callahan, Michael R.; Pensinger, Stuart; Pickering, Karen D.

    2011-01-01

    The Brine Residual In-Containment (BRIC) concept was developed as a new technology to recover water from spacecraft wastewater brines. Such capability is considered critical to closing the water loop and achieving a sustained human presence in space. The intention of the BRIC concept is to increase the robustness and efficiency of the dewatering process by performing drying inside the container used for the final disposal of the residual brine solid. Recent efforts in the development of BRIC have focused on preliminary feasibility testing using a laboratory- assembled pre-prototype unit. Observations of the drying behavior of actual brine solutions processed under BRIC-like conditions has been of particular interest. To date, experiments conducted with three types of analogue spacecraft wastewater brines have confirmed the basic premise behind the proposed application of in-place drying for these solutions. Specifically, the dried residual mass from these solutions have tended to exhibit characteristics of adhesion and flow that are expected to continue to challenge process stream management in spacecraft brine dewatering system designs. Yet, these same characteristics may favor the development of capillary- and surface-tension-based approaches envisioned as part of an ultimate microgravity-compatible BRIC design. In addition, preliminary feasibility testing of the BRIC pre-prototype confirmed that high rates of water recovery, up to 98% of the available brine water, may be possible while still removing the majority of the brine contaminants from the influent brine stream. These and other observations from testing are reported.

  12. Solar Stirling power generation - Systems analysis and preliminary tests

    Science.gov (United States)

    Selcuk, M. K.; Wu, Y.-C.; Moynihan, P. I.; Day, F. D., III

    1977-01-01

    The feasibility of an electric power generation system utilizing a sun-tracking parabolic concentrator and a Stirling engine/linear alternator is being evaluated. Performance predictions and cost analysis of a proposed large distributed system are discussed. Design details and preliminary test results are presented for a 9.5 ft diameter parabolic dish at the Jet Propulsion Laboratory (Caltech) Table Mountain Test Facility. Low temperature calorimetric measurements were conducted to evaluate the concentrator performance, and a helium flow system is being used to test the solar receiver at anticipated working fluid temperatures (up to 650 or 1200 C) to evaluate the receiver thermal performance. The receiver body is designed to adapt to a free-piston Stirling engine which powers a linear alternator assembly for direct electric power generation. During the next phase of the program, experiments with an engine and receiver integrated into the concentrator assembly are planned.

  13. Description and Preliminary Testing of the CDSN Seismic Sensor Systems

    Science.gov (United States)

    Peterson, Jon; Tilgner, Edwin E.

    1985-01-01

    INTRODUCTION The China Digital Seismograph Network (CDSN) is being designed and installed to provide the People's Republic of China with the facilities needed to create a national digital database for earthquake research. The CDSN, which is being developed jointly by the PRC State Seismological Bureau and the U.S. Geological Survey, will consist initially of nine digitally-recording seismograph stations, a data management system to be used for compiling network-day tapes, and a depot maintenance center. Data produced by the network will be shared with research scientists throughout the world. A national seismograph network must be designed to support a variety of research objectives. From this standpoint, the choices and tradeoffs involved in specifying signal bandwidth, resolution, and dynamic range are the most important decisions in system design. As in the case of the CDSN, these decisions are made during the selection and design of the seismic sensor system and encoder components. The purpose of this report is to describe the CDSN sensor systems, their important signal characteristics, and the results of preliminary tests that have been performed on the instruments. Four overlapping data bands will be recorded at each station: short period (SP), broadband (BB), long period (LP), and very long period (VLP). Amplitude response curves are illustrated in Figure I. Vertical and horizontal components will be recorded for each data band. The SP and LP channels will be recorded with sufficient sensitivities to resolve earth background noise at seismically quiet sites. The BB channels will have a lower sensitivity and are intended for broadband recording of moderate-to-large body-wave signals and for increasing the effective amplitude range in the short- and long-period bands. The VLP channel does not provide additional spectral coverage at long periods; its purpose is to make use of on-site filtration and decimation to reduce post processing requirements for VLP

  14. Design and preliminary test results of Daya Bay RPC modules*

    Energy Technology Data Exchange (ETDEWEB)

    Hackenburg, R.

    2011-09-01

    Resistive Plate Chamber (RPC) modules will be used as one part of the cosmic muon veto system in the Daya Bay reactor neutrino experiment. A total of 189 RPC modules will cover the three water pools in the experiment. To achieve track reconstruction and high efficiency, each module consists of 4 layers, each of which contains two sizes of bare chambers. The placement of bare chambers is reversed in different layers to reduce the overlapping dead areas. The module efficiency and patch efficiency were studied both in simulation and test of the data analysis. 143 modules have been constructed and tested. The preliminary study shows that the module and patch 3 out of 4 layers efficiency reaches about 98%.

  15. Design and preliminary test results of Daya Bay RPC modules

    Institute of Scientific and Technical Information of China (English)

    XU Ji-Lei; Logan Lebanowski; Cullen Newsom; Lin Shih-Kai; Jonathan Link; MA Lie-Hua; Viktor Pě(c); Vit Vorobel; CHEN Jin; LIU Jin-Chang; ZHOU Yong-Zhao; GUAN Meng-Yun; LIANG Hao; YANG Chang-Gen; WANG Yi-Fang; ZHANG Jia-Wen; LU Chang-Guo; Kirk McDonald; Robert Hackenburg; Kwong Lau

    2011-01-01

    Resistive Plate Chamber(RPC)modules will be used as one part of the cosmic muon veto system in the Days Bay reactor neutrino experiment.A total of 189 RPC modules will cover the three water pools in the experiment.To achieve track reconstruction and high efficiency,each module consists of 4 layers,each of which contains two sizes of bare chambers.The placement of bare chambers is reversed in different layers to reduce the overlapping dead areas.The module efficiency and patch efficiency were studied both in simulation and test of the data analysis.143 modules have been constructed and tested.The preliminary study shows that the module and patch 3 out of 4 layers efficiency reaches about 98%.

  16. Preliminary dimensioning of the IFMIF Tritium Release Test Module

    Energy Technology Data Exchange (ETDEWEB)

    Arbeiter, Frederik, E-mail: frederik.arbeiter@kit.edu; Abou-Sena, Ali; Chen, Yuming; Freund, Jana; Klix, Axel; Kondo, Keitaro; Vladimirov, Pavel

    2013-10-15

    Highlights: • The design of the IFMIF Tritium Release Test Module is explained. • Nuclear responses in the module and specimens are calculated. • Temperature fields during irradiation are calculated by 1D methods. • The tritium budget is calculated by 1D methods. -- Abstract: As part of the ongoing Engineering Validation and Engineering Design Activities for the International Fusion Materials Irradiation Facility (IFMIF), an experimental device suitable for the irradiation and online tritium release measurements of solid breeder ceramics and beryllium is investigated. This experimental device is called the Tritium Release Test Module (TRTM). In the preliminary design phase, the possible thermal conditions, the tritium diffusion budgets, and the mechanical loads have been studied by analytical calculations and numerical codes. The most important results concern the tritium production and nuclear heating induced in the structures, the temperature distribution in the specimen region and the structure, and the diffusion of tritium through the safety barriers.

  17. Lamb waves increase sensitivity in nondestructive testing

    Science.gov (United States)

    Di Novi, R.

    1967-01-01

    Lamb waves improve sensitivity and resolution in the detection of small defects in thin plates and small diameter, thin-walled tubing. This improvement over shear waves applies to both longitudinal and transverse flaws in the specimens.

  18. Retrospective evaluation of the consequence of alleged patch test sensitization

    DEFF Research Database (Denmark)

    Jensen, Charlotte D; Paulsen, Evy; Andersen, Klaus E

    2006-01-01

    consequences in cases of possible patch test sensitization. Among 7619 consecutively tested eczema patients in a 14-year period 26 (0.3%) were identified in the database as having had a late patch test reaction, which may be an indication of patch test sensitization. 9 of these cases were not suitable....... For the remaining 11 patients we could not rule out that they were patch test sensitized, and they were investigated further. 1 was diseased and 10 were interviewed regarding the possible consequences of the alleged patch test sensitization. 9 had not experienced any dermatitis problems, and 1 could not exclude...

  19. Results of Preliminary Tests of PAR Bunch Cleaning

    CERN Document Server

    Yao, Chihyuan; Grelick, Arthur; Lumpkin, Alex H; Sereno, Nicholas S

    2005-01-01

    A particle accumulator ring (PAR) is used at the Advanced Photon Source (APS) to collect multiple linac bunches and compress them into a 0.3-ns (rms) single bunch for booster injection. A 9.77-MHz fundamental rf system and a 117.3-MHz harmonic rf system are employed for initial beam capture and bunch length compression. Satellite bunches with very low charge form due to rf phase drifts or beam loading change. These satellites, when injected into the booster and then into the storage ring (SR), cause bunch impurity at three buckets from the target bucket. Storage ring and booster bunch cleaning was tried but proved to be difficult due to the top-up mode of operation in the storage ring and tune drift in the booster synchrotron. Recently we implemented a PAR bunch-cleaning system with tune-modulated harmonic rf knockout. Preliminary tests gave a measured SR bunch purity of better than 10

  20. Installation of ECR2 at LNS and Preliminary tests

    CERN Document Server

    Gammino, S; Ciavola, G; Castro, M; Chines, F; Marletta, S; Bieth, C; Sortais, P; Kantas, S

    1999-01-01

    The source ECR2 has been built in 1998 by Pantechnik, according to the design suggested by LNS Ion Source Group. This design entails some improvements with respect to a standard CAPRICE-type source: a) the magnetic field (up to 1.6 T axial, 1.1 T radial) allows to operate the source at 14 GHz in High B mode and at 18 GHz; b) two frequency heating can be used; c) an aluminum made plasma chamber is used in place of the stainless steel one. The main features of ECR2 along with a review of the preliminary tests will be outlined. Typical currents for fully stripped nitrogen are about 25 emA; for the heaviest ions, 1 emA of Kr28+ and 10 emA of Ta27+ have been measured. The installation at LNS has been completed recently and the details will be given.

  1. Sensitivity Tests for Cumulative Damage Function (CDF) for the PGSFR

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Chiwoong; Ha, Kwiseok [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-10-15

    A safety analysis including the design basis and beyond design basis events has been conducted using MARS-LMR. Previous safety limits were based on temperature and the duration time. However, the cumulative damage function (CDF) will be used as the safety limit to evaluate the fuel cladding integrity. Recently, a 4S reactor developed by Toshiba used the same approach for a safety analysis. Therefore, the development a CDF is necessary to evaluate the safety limit for the PGSFR safety analyses. The major keys in the CDF model are behavior of fuel and cladding. It is not easy to obtain a metallic fuel database for a CDF model including the cladding materials. Argonne National Laboratory (ANL) in the United States is the only major leading group for metallic fuel experiments. They conducted various experiments with various facilities and experimental reactors, for example, EBR-II, FFTF, and TREAT. In addition, they have recently been trying to extend their oxide fuel based a severe accident code, SAS4A/SASSYS, to a metallic fuel version using their metallic fuel database. In this study, the preliminary CDF model was supplemented in the MARS-LMR code. The major source was the SAS4A/SASSYS modules related to fuel and cladding transient behaviors.. In addition, a sensitivity test for some parameters in the CDF model was conducted to evaluate the capability of these models and to find the major parameter of fuel failure. The Cumulative Damage Function is a good indicator for a fuel failure. The major parameters for the CDF model are selected including cladding and fuel temperatures, initial pressure and volume in the gas plenum, clad thickness, and fission power in the fuel pin. The most sensitive parameter is the cladding temperature. Also, cladding thickness and gas pressure in the fuel pin are effective parameters on the CDF. During an actual transient, various parameter including sensitivity test parameters in this study will be changed simultaneously. This study can

  2. Performance characteristics of DRI, CEDIA, and REMEDi systems for preliminary tests of amphetamines and opiates in human urine.

    Science.gov (United States)

    Huang, Min-Kun; Dai, Yu-Shan; Lee, Choung-Huei; Liu, Chiareiy; Tsay, Wen-Ing; Li, Jih-Heng

    2006-01-01

    Arrestee urine specimens (930) were tested with DRI, CEDIA, and REMEDi; those that tested positive for amphetamines and opiates (616 and 414, respectively) were then confirmed by gas chromatography-mass spectrometry. The performance characteristics of these three preliminary systems were evaluated using the following commonly used parameters: true positive, true negative, false positive, and false negative. The sensitivity, specificity, and efficiency of these methods were also calculated. Data derived from this study indicated DRI and CEDIA adapted by this study generated acceptable preliminary test results for amphetamine/methamphetamine and morphine/codeine, but not for MDA/MDMA and REMEDi has lower sensitivity than DRI and CEDIA, but with better specificity and efficiency, supporting its use under emergency room settings where drug concentrations in overdose cases are expectedly at high levels.

  3. Thick Concrete Specimen Construction, Testing, and Preliminary Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Clayton, Dwight A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hoegh, Kyle [Univ. of Minnesota, Minneapolis, MN (United States); Khazanovich, Lev [Univ. of Minnesota, Minneapolis, MN (United States)

    2015-03-01

    The purpose of the U.S. Department of Energy Office of Nuclear Energy’s Light Water Reactor Sustainability (LWRS) Program is to develop technologies and other solutions that can improve the reliability, sustain the safety, and extend the operating lifetimes of nuclear power plants (NPPs) beyond 60 years. Since many important safety structures in an NPP are constructed of concrete, inspection techniques must be developed and tested to evaluate the internal condition. In-service containment structures generally do not allow for the destructive measures necessary to validate the accuracy of these inspection techniques. This creates a need for comparative testing of the various nondestructive evaluation (NDE) measurement techniques on concrete specimens with known material properties, voids, internal microstructure flaws, and reinforcement locations. A preliminary report detailed some of the challenges associated with thick reinforced concrete sections and prioritized conceptual designs of specimens that could be fabricated to represent NPP concrete structures for using in NDE evaluation comparisons. This led to the construction of the concrete specimen presented in this report, which has sufficient reinforcement density and cross-sectional size to represent an NPP containment wall. Details on how a suitably thick concrete specimen was constructed are presented, including the construction materials, final nominal design schematic, as well as formwork and rigging required to safely meet the desired dimensions of the concrete structure. The report also details the type and methods of forming the concrete specimen as well as information on how the rebar and simulated defects were embedded. Details on how the resulting specimen was transported, safely anchored, and marked to allow access for systematic comparative NDE testing of defects in a representative NPP containment wall concrete specimen are also given. Data collection using the MIRA Ultrasonic NDE equipment and

  4. [Peritoneal equilibration test: Conventional versus adapted. Preliminary study].

    Science.gov (United States)

    Zaloszyc, Ariane; Schmitt, Claus Peter; Schaefer, Betti; Doutey, Armelle; Terzic, Joëlle; Menouer, Soraya; Higel, Laetitia; Fischbach, Michel

    2017-02-01

    Conventional automated peritoneal dialysis (APD) is prescribed as a repetition of cycles with the same dwell time and the same fill volume. Water and sodium balance remains a common problem among patients on peritoneal dialysis. More recently, adapted automated peritoneal dialysis was described, as a combination of short dwells with a low volume, in order to enhance ultrafiltration, followed by long dwells with a large fill volume to favor solute removal. We performed a preliminary crossover study on 4 patients. The total amount of dialysate was the same, i.e. 2L/m(2) as well as the total duration of the test, i.e. 150 minutes. The conventional test was made with two identical cycles, each cycle had a fill volume of 1L/m(2) and a duration of 75 minutes, while the adapted test was performed with one short cycle, i.e. 30 minutes with a low fill volume, i.e. 0.6L/m(2), followed by a long cycle, i.e. 120 minutes, with a large fill volume, i.e. 1.4L/m(2). Sodium extraction was improved by 29.3mmol/m(2) (169%) in the adapted test in comparison to the conventional test. Ultrafiltration was enhanced by 159mL/m(2) (128%) in the adapted test compared to the conventional one. Glucose absorption was decreased by 35% in the adapted test in comparison to the conventional test and osmotic conductance was also improved. In conclusion, adapted dialysis may allow for a better volume and sodium balance, since we observed an improvement in sodium extraction and ultrafiltration. This pre-study authorizes an improvement of the European Pediatric Study's protocol on Adapted APD, already started and which will continue in the next months. Copyright © 2016 Association Société de néphrologie. Published by Elsevier SAS. All rights reserved.

  5. Preliminary study of an immunochromatography test for serological diagnosis of canine brucellosis.

    Science.gov (United States)

    Wanke, M M; Cairó, F; Rossano, M; Laiño, M; Baldi, P C; Monachesi, N E; Comercio, E A; Vivot, M M

    2012-12-01

    The most widely used screening test for the diagnosis of brucellosis in the dog is the rapid slide agglutination test in the presence of 2-mercaptoethanol (2ME-RSAT). The diagnosis is partially confirmed by the agar gel immunodiffusion test (AGID) and definitively confirmed by bacteriological isolation. Some chronic cases not detected by these tests may be detected by ELISA tests. The use of 2ME-RSAT in routine clinical practice requires a microscope and an experienced operator. An immunochromatographic diagnostic test for canine brucellosis (FASTest(®) Brucella c., Megacor, Hörbranz, Austria) has been recently released. In this study, we compared the diagnostic performance of the FASTest with those of 2ME-RSAT, AGID and ELISAs. Sera from 17 healthy dogs used as negative controls yielded negative results by FASTest, indicating a 100% specificity in this sample. Among 27 sera of dogs with acute or subacute brucellosis confirmed by B. canis isolation, all of which were positive by RSAT and ELISAs, the FASTest was positive in 24 cases and AGID in 23. In acute and subacute cases, the sensitivity of FASTest was 89%. Sera from six dogs with bacteriologically confirmed chronic brucellosis, which were positive by ELISAs but negative by 2ME-RSAT, were also tested; 1 was positive by FASTest and 4 were positive by AGID. These preliminary results indicate a good specificity of the FASTest (100% in this sample) but an unacceptable sensitivity as a screening test. In cases with chronic brucellosis, the sensitivity of the FASTest was lower than that of ELISAs but this assay could make a good intermediate test to be run after a positive RSAT and before running an AGID.

  6. Sensitivity of solid rocket propellants for card gap test

    Energy Technology Data Exchange (ETDEWEB)

    Kimura, Eishu; Oyumi, Yoshio (Japan Defense Agency, Tokyo (Japan). Technical Research and Development Inst.)

    1999-05-01

    Card gap test, which is standardized in Japan Explosives Society, was modified in order to apply it to solid rocket propellants and carried out to evaluate sensitivities against shock stimuli. Solid propellants tested here were mainly azide polymer composite propellants, which contained ammonium nitrate (AN) as a main oxidizer. Double base propellant, composed nitroglycerin and nitrocellulose (NC), and ammonium perchlorate (AP)-based composite propellants. It is found that the sensitivity was dominated by the oxidizer characteristics. AP- and AN-based propellant had less sensitivity and HMX-based propellant showed higher sensitivity, and the adding of NC and TMETN contributed to worse sensitive for the card gap test. Good relationship was obtained between the card gap sensitivity and the oxygen balance of propellants tested here. (orig.)

  7. Initial results of sensitivity tests - Performed on the RE-1000 free-piston Stirling engine

    Science.gov (United States)

    Schreiber, J. G.

    1984-01-01

    Tests have been performed over several years to investigate the dynamics of a free-piston Stirling engine for the purpose of computer code validation. Tests on the 1 kW (1.33 hp) single cylinder engine have involved the determination of the sensitivity of the engine performance to variations in working space pressure, heater and cooler temperatures, regenerator porosity, power piston mass, and displacer dynamics. Maps of engine performance have been recorded with the use of an 81.2 percent porosity regenerator. Both a high-efficiency displacer and a high-power displacer were tested; efficiencies up to 33 percent were recorded, and power output of approximately 1500 W was obtained. Preliminary results of the sensitivity tests are presented, and descriptions of future tests are given.

  8. In vitro preliminary cytotoxicity testing of vegetal extracts, using colorimetric methods

    Directory of Open Access Journals (Sweden)

    Claudia Patricia Cordero Camacho

    2011-12-01

    Full Text Available To advance in the study of the Colombian vegetal biodiversity, considered as a potential source of pharmacologically active products, the establishment of biological activity evaluation systems is necessary, which allow the detection of active products against pathologies with high social and economical impact, such as cancer. This work describes the implementation of a preliminary in vitro methodology for the determination of potential anticancer activity in vegetal extracts, by cytotoxicity testing upon human tumor cell lines, measuring the cellular mass indirectly with the colorimetric assays of MTT (methyl tetrazolium tiazole reduction and SRB (sulforhodamine Bstaining. HT-29, MCF-7, SiHa and HEp-2 cell lines cultures were adapted, MTT concentration, cellular density and treatment period parameters for the cytotoxicity assay were selected. Cell lines sensitivity to the chemotherapeutic agent Doxorubicin HCl was determined. Colombian vegetal species extracts cytotoxicity was tested and usefulness of the assay as a tool to bioguide the search of active products was evidenced.

  9. Environmental Survey preliminary report, Nevada Test Site, Mercury, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    1988-04-01

    This report presents the preliminary findings from the first phase of the Environmental Survey of the United States Department of Energy (DOE) Nevada Test Site (NTS), conducted June 22 through July 10, 1987. The Survey is being conducted by a multidisciplinary team of environmental specialists led and managed by the Office of Environment, Safety and Health's Office of Environmental Audit. Individual team members are outside experts being supplied by a private contractor. The objective of the Survey is to identify environmental problems and areas of environmental risk associated with the NTS. The Survey covers all environment media and all areas of environmental regulation. It is being performed in accordance with the DOE Environmental Survey Manual. This phase of the Survey involves the review of existing site environmental data, observations of the operations and activities performed at the NTS, and interviews with site personnel. The Survey team developed a Sampling and Analysis Plan to assist in further assessing certain environmental problems identified during its on-site activities. The Sampling and Analysis Plan is being executed by the Battelle Columbus Division under contract with DOE. When completed, the results will be incorporated into the NTS Environmental Survey Interim Report. The Interim Report will reflect the final determinations of the NTS Survey. 165 refs., 42 figs., 52 tabs.

  10. Preliminary Tests Of The Decris-sc Ion Source

    CERN Document Server

    Efremov, A; Bechterev, V; Bogomolov, S L; Bondarenko, P G; Datskov, V I; Dmitriev, S; Drobin, V; Lebedev, A; Leporis, M; Malinowski, H; Nikiforov, A; Paschenko, S V; Seleznev, V; Shishov, Yu A; Smirnov, Yu; Tsvineva, G; Yakovlev, B; Yazvitsky, N Yu

    2004-01-01

    A new "liquid He-free" superconducting Electron Cyclotron Resonance Ion Source DECRIS-SC, to be used as injector for the IC-100 small cyclotron, has been designed by FLNR and LHE JINR. The main feature is that a compact refrigerator of Gifford-McMahon type is used to cool the solenoid coils. For the reason of very small cooling power at 4.2 K (about 1 W) our efforts were to optimize the magnetic structure and minimize an external heating of the coils. The maximum magnetic field strength is 3 T and 2 T in injection and extraction region respectively. For the radial plasma confinement a hexapole made of NdFeB permanent magnet is used. The source will be capable of ECR plasma heating using different frequencies (14 GHz or 18 GHz). To be able to deliver usable intensities of solids, the design is also allow axial access for evaporation oven and metal samples using the plasma sputtering technique. Very preliminary results of the source test are presented.

  11. Highly sensitive silicon microreactor for catalyst testing

    DEFF Research Database (Denmark)

    Henriksen, Toke Riishøj; Olsen, Jakob Lind; Vesborg, Peter Christian Kjærgaard;

    2009-01-01

    by directing the entire gas flow through the catalyst bed to a mass spectrometer, thus ensuring that nearly all reaction products are present in the analyzed gas flow. Although the device can be employed for testing a wide range of catalysts, the primary aim of the design is to allow characterization of model...... catalysts which can only be obtained in small quantities. Such measurements are of significant fundamental interest but are challenging because of the low surface areas involved. The relationship between the reaction zone gas flow and the pressure in the reaction zone is investigated experimentally......, it is found that platinum catalysts with areas as small as 15 mu m(2) are conveniently characterized with the device. (C) 2009 American Institute of Physics. [doi:10.1063/1.3270191]...

  12. Preliminary Sensitivity Study of Upper Head Nodalization for LBLOCA in APR-1400

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Dong Gu; Yoo, Seung Hun; Cho, Dae-Hyung [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2015-10-15

    In this study, the key-way bypass was determined to be - 0.3 %. The steady state condition which is the initial condition for LBLOCA was obtained by MARS-KS calculation. Up to now, it was assumed that the temperature of the upper dome in APR-1400 was close to that of the cold leg. However, it was found that the temperature of the upper head/dome might be a little lower than or similar to that of the hot leg through the evaluation of the detailed design data. Since the higher upper head temperature affects blowdown quenching and peak cladding temperature in the reflood phase, the nodalization for upper head should be modified. In this study, the preliminary sensitivity study of original and modified nodalization for LBLOCA was performed, and the effect of upper head nodalization and temperature was evaluated qualitatively. In this study, the preliminary sensitivity study of original and modified nodalization for upper head in APR-1400 was performed, and the effect of upper head nodalization and temperature on LBLOCA PCT was evaluated qualitatively. Through the transient calculation, it was confirmed that the upper head temperature affects the water inventory in the upper head at the early stage of LBLOCA so it does the blowdown quenching and following reflood PCT significantly. The results in this study were caused by very conservative upper head temperature determination.

  13. Comparison of the sensitivities of the Buehler test and the guinea pig maximization test for predictive testing of contact allergy

    DEFF Research Database (Denmark)

    Frankild, S; Vølund, A; Wahlberg, J E;

    2001-01-01

    dose-response model. To compare the sensitivity of the 2 test procedures the test conditions were kept identical and the following chemicals with a range of sensitization potentials were tested: chloraniline, chlorhexidine, eugenol, formaldehyde, mercaptobenzothiazole and neomycin sulphate....... Formaldehyde and neomycin sulphate were strong sensitizers in both tests. Mercaptobenzothiazole, eugenol and chloraniline were all strong sensitizers in the GPMT, eugenol and mercaptobenzothiazole were negative in the Buehler test and equivocal results were obtained with chloraniline. Chlorhexidine...

  14. Interpreting IgE sensitization tests in food allergy.

    Science.gov (United States)

    Chokshi, Niti Y; Sicherer, Scott H

    2016-01-01

    Food allergies are increasing in prevalence, and with it, IgE testing to foods is becoming more commonplace. Food-specific IgE tests, including serum assays and prick skin tests, are sensitive for detecting the presence of food-specific IgE (sensitization), but specificity for predicting clinical allergy is limited. Therefore, positive tests are generally not, in isolation, diagnostic of clinical disease. However, rationale test selection and interpretation, based on clinical history and understanding of food allergy epidemiology and pathophysiology, makes these tests invaluable. Additionally, there exist highly predictive test cutoff values for common allergens in atopic children. Newer testing methodologies, such as component resolved diagnostics, are promising for increasing the utility of testing. This review highlights the use of IgE serum tests in the diagnosis of food allergy.

  15. The Cleveland Sorting Test: a preliminary study of an alternate form of the Wisconsin Card-Sorting Test.

    Science.gov (United States)

    Poreh, Amir; Pastel, Dan; Miller, Ashley; Levin, Jennifer

    2012-01-01

    During the past two decades, studies have repeatedly shown that the Wisconsin Card-Sorting Test (WCST) is not as sensitive to prefrontal-lobe functioning as was originally suspected. Specifically, both clinical and brain-imaging studies have shown that several distinct neural circuits contribute to one's ability to successfully complete different aspects of the test. Another limitation of the WCST is its length, which makes it difficult and frustrating for certain clinical populations. To address the above limitations, researchers have proposed the development of new indexes and the integration of an adaptive testing approach that will allow for the premature termination of the test. Unfortunately, given the proprietary nature of the WCST, none of the above recommendations have been adopted. The present preliminary study examined an alternate form of the 64-Item WCST (WCST-64), the Cleveland Sorting Test (CST-64). The normative data of the two measures as well as the total number of errors, perseverative responses, perseverative errors, and categories completed were compared using a repeated-measures design. Overall, the study supports psychometric approximation of the CST-64 and the WCST-64. Suggestions for future studies and modifications of the CST-64, including the use of recently proposed indexes and adaptive administration approaches, are provided.

  16. The Development and Validation of the Vocalic Sensitivity Test.

    Science.gov (United States)

    Villaume, William A.; Brown, Mary Helen

    1999-01-01

    Notes that presbycusis, hearing loss associated with aging, may be marked by a second dimension of hearing loss, a loss in vocalic sensitivity. Reports on the development of the Vocalic Sensitivity Test, which controls for the verbal elements in speech while also allowing for the vocalics to exercise their normal metacommunicative function of…

  17. Stressful events and psychological difficulties : Testing alternative candidates for sensitivity

    NARCIS (Netherlands)

    Laceulle, Odilia M.|info:eu-repo/dai/nl/364227885; O'Donnell, Kieran; Glover, Vivette; O'Connor, Thomas G.; Ormel, Johan; Van Aken, Marcel A G|info:eu-repo/dai/nl/081831218; Nederhof, Esther

    2014-01-01

    The current study investigated the longitudinal, reciprocal associations between stressful events and psychological difficulties from early childhood to mid-adolescence. Child age, sex, prenatal maternal anxiety, and difficult temperament were tested as sources of sensitivity, that is, factors that

  18. Stressful events and psychological difficulties : testing alternative candidates for sensitivity

    NARCIS (Netherlands)

    Laceulle, Odilia M.; O'Donnell, Kieran; Glover, Vivette; O'Connor, Thomas G.; Ormel, Johan; van Aken, Marcel A. G.; Nederhof, Esther

    2014-01-01

    The current study investigated the longitudinal, reciprocal associations between stressful events and psychological difficulties from early childhood to mid-adolescence. Child age, sex, prenatal maternal anxiety, and difficult temperament were tested as sources of sensitivity, that is, factors that

  19. LLNL small-scale drop-hammer impact sensitivity test

    Energy Technology Data Exchange (ETDEWEB)

    Simpson, L.R.; Foltz, M.F.

    1995-01-01

    Small-scale safety testing of explosives and other energetic materials is done to determine their sensitivity to various stimuli including friction, static spark, and impact. This testing is typically done to discover potential handling problems for either newly synthesized materials of unknown behavior or materials that have been stored for long periods of time. This report describes the existing ``ERL Type 12 Drop Weight Impact Sensitivity Apparatus``, or ``Drop Hammer Machine``, and the methods used to determine the impact sensitivity of energetic materials, Also discussed are changes made to both the machine and methods since the inception of impact sensitivity testing at LLNL in 1956. The accumulated data for the materials tested in not listed here, the exception being the discussion of those specific materials (primary calibrants: PETN, RDX, Comp-B3,and TNT; secondary calibrants: K-6, RX-26-AF, and TATB) used to calibrate the machine.

  20. Accelerated stress testing of thin film solar cells: Development of test methods and preliminary results

    Science.gov (United States)

    Lathrop, J. W.

    1985-01-01

    If thin film cells are to be considered a viable option for terrestrial power generation their reliability attributes will need to be explored and confidence in their stability obtained through accelerated testing. Development of a thin film accelerated test program will be more difficult than was the case for crystalline cells because of the monolithic construction nature of the cells. Specially constructed test samples will need to be fabricated, requiring committment to the concept of accelerated testing by the manufacturers. A new test schedule appropriate to thin film cells will need to be developed which will be different from that used in connection with crystalline cells. Preliminary work has been started to seek thin film schedule variations to two of the simplest tests: unbiased temperature and unbiased temperature humidity. Still to be examined are tests which involve the passage of current during temperature and/or humidity stress, either by biasing in the forward (or reverse) directions or by the application of light during stress. Investigation of these current (voltage) accelerated tests will involve development of methods of reliably contacting the thin conductive films during stress.

  1. Effects of sensitive electrical stimulation based cueing in Parkinson's disease: a preliminary study

    Directory of Open Access Journals (Sweden)

    Benoît Sijobert

    2016-06-01

    Full Text Available This study aims to investigate the effect of a sensitive cueing on Freezing of Gait (FOG and gait disorders in subjects suffering from Parkinson’s disease (PD. 13 participants with Parkinson’s disease were equipped with an electrical stimulator and a foot mounted inertial measurement unit (IMU. An IMU based algorithm triggered in real time an electrical stimulus applied on the arch of foot at heel off detection. Starting from standing, subjects were asked to walk at their preferred speed on a path comprising 5m straight, u-turn and walk around tasks. Cueing globally decreased the time to achieve the different tasks in all the subjects. In “freezer” subjects, the time to complete the entire path was reduced by 19%. FOG events occurrence was lowered by 12% compared to baseline before and after cueing. This preliminary work showed a positive global effect of an electrical stimulation based cueing on gait and FOG in PD.

  2. Sensitivity Analysis for DHRS Heat Exchanger Performance Tests of PGSFR

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Jonggan; Eoh, Jaehyuk; Kim, Dehee; Lee, Taeho; Jeong, Jiyoung [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    The STELLA-1 facility has been constructed and separate effect tests of heat exchangers for DHRS are going to be conducted. Two kinds of heat exchangers including DHX (shell-and-tube sodium-to-sodium heat exchanger) and AHX (helical-tube sodium-to-air heat exchanger) will be tested for design codes V and V. Main test points are a design point and a plant normal operation point of each heat exchanger. Additionally, some plant transient conditions are taken into account for establishing a test condition set. To choose the plant transient test conditions, a sensitivity analysis has been conducted using the design codes for each heat exchanger. The sensitivity of the PGSFR DHRS heat exchanger tests (the DHX and AHX in the STELLA-1 facility) has been analyzed through a parametric study using the design codes SHXSA and AHXSA at the design point and the plant normal operation point. The DHX heat transfer performance was sensitive to the change in the inlet temperature of the shell-side and the AHX heat transfer performance was sensitive to the change in the inlet temperature of the tube side. The results of this work will contribute to an improvement of the test matrix for the separate effect test of each heat exchanger.

  3. Advances in techniques of testing mycobacterial drug sensitivity, and the use of sensitivity tests in tuberculosis control programmes

    Science.gov (United States)

    Canetti, G.; Fox, Wallace; Khomenko, A.; Mahler, H. T.; Menon, N. K.; Mitchison, D. A.; Rist, N.; Šmelev, N. A.

    1969-01-01

    In a paper arising out of an informal international consultation of specialists in the bacteriology of tuberculosis held in 1961, an attempt was made to formulate criteria, and specify technical procedures, for reliable tests of sensitivity (the absolute-concentration method, the resistance-ratio method and the proportion method) to the 3 main antituberculosis drugs (isoniazid, streptomycin and p-aminosalicylic acid). Seven years later, a further consultation was held to review the latest developments in the field and to suggest how sensitivity tests might be put to practical use in tuberculosis control programmes. The participants reached agreement on how to define drug sensitivity and resistance, and stressed the importance of using a discrimination approach to the calibration of sensitivity tests. Their views are contained in the present paper, which also includes descriptions of the sensitivity tests used by the Medical Research Council of Great Britain for first- and second-line drugs (minimal inhibitory concentration and resistance-ratio methods), the two main variants of the proportion method developed by the Institut Pasteur, Paris, and a method for calibrating sensitivity tests. PMID:5309084

  4. Preliminary test results from the CELSS Test Facility Engineering Development Unit

    Science.gov (United States)

    Kliss, Mark H.; Macelroy, R. D.; Blackwell, C. C.; Borchers, B. A.; Drews, M. E.; Longabaugh, J. R.; Yendler, B. S.; Zografos, A. I.

    1994-01-01

    As part of the NASA Controlled Ecological Life Support System (CELSS) Program, a CELSS Test Facility (CTF) is being planned for installation on the Space Station. The CTF will be used to provide data on the productivity and efficiency of a variety of CELSS higher plant crops grown in the microgravity environment of the Space Station. Tight environmental control will be maintained while data on gas exchange rates and biomass accumulation rates are collected. In order to obtain an early realistic determination of the subsystem and system requirements necessary to provide the environmental conditions specified for CTF crop productivity experiments, an Engineering Development Unit (EDU) has been designed, constructed and is in the process of subsystem and system testing at NASA Ames Research Center. The EDU is a ground test-bed which will be used to characterize the integrated performance of major subsystem technologies, to evaluate hardware candidates and control strategies required for the CTF, and to further define the ability to meet CTF requirements within present Space Station constraints. This paper reviews the functional requirements for the EDU, and focuses on the performance evaluation and test results of the various subsystems. Preliminary integrated performance results and control system operation are addressed, and plans for future science and technology testing are discussed.

  5. Method of Testing the Flyer Sensitivity of Explosives

    Institute of Scientific and Technical Information of China (English)

    王桂吉; 赵剑衡

    2004-01-01

    By means of Mylar flyer shock explosives driven by electric gun, the method of testing the flyer initiation sensitivity of explosives is studied, and some experiments are done. The experimental results show that the test method established is correct, which is very important and instructive to study and evaluate the safety and reliability of explosives. For the moment, the test should be researched and discussed further.

  6. Establishing relative sensitivities of various toxicity testing organisms to ammonia

    Energy Technology Data Exchange (ETDEWEB)

    Karle, L.M.; Mayhew, H.L.; Barrows, M.E.; Karls, R.K. [Battelle/Marine Sciences Lab., Sequim, WA (United States)

    1994-12-31

    The toxicity of ammonia to various organisms was examined to develop a baseline for mortality in several commonly used testing species. This baseline data will assist in choosing the proper test species and in interpreting results as they pertain to ammonia. Responses for two juvenile fish species, three marine amphipods, and two species of mysid shrimp were compared for their sensitivity to levels of ammonia. All mortality caused by ammonia in the bottom-dwelling Citharichthys stigmaeus occurred within 24 h of exposure, whereas mortality in the silverside, Menidia beryllina, occurred over the entire 96-h test duration. Responses to ammonia varied among the amphipods Rhepoxynius abronius, Ampelisca abdita, and Eohaustorius estuarius. R. abronius and A. abdita showed similar sensitivity to ammonia at lower concentrations; A. abdita appeared more sensitive than R. abronius at levels above 40 mg/L. Concentrations of ammonia required to produce significant mortality in the amphipod E. estuarius were far higher than the other species examined (> 100 mg/L NH{sub 3}). A comparison of ammonia toxicity with two commonly used invertebrates, Holmesimysis sculpts and Mysidopsis bahia, suggest that these two species of mysid have similar sensitivities to ammonia. Further studies with ammonia that examine sensitivity of different organisms should be conducted to assist regulatory and environmental agencies in determining appropriate test species and in interpreting toxicological results as they may be affected by levels of ammonia.

  7. [Detection of cancer, sensitivity of the test and sensitivity of the screening program].

    Science.gov (United States)

    Launoy, G; Duffy, S W; Prevost, T C; Bouvier, V

    1998-11-01

    In assessment of screening for cancer, no distinction is usually made between the sensitivity of the screening test (St) and the sensitivity of the screening program (Sp). This paper was aimed to distinguish meaning, method for assessment and interest for each of them, and to determine their relationship. Sensitivity of the screening program can be directly assessed with data from on-going trials whilst assessment of sensitivity of screening test requires modelisation techniques, especially for assessing the mean duration of the preclinical phase of cancer. Assuming an exponential distribution of this duration, lambda as the time parameter, a mathematical relation between St and Sp is suggested as follows: [formula: see text] with r being the interval between two screening tests. The implementation of this equation with data from a mass-screening program for colorectal cancer in the department of Calvados allowed us to investigate the influence of the mean preclinical phase and the interval between two screening tests on the value of the sensitivity of the screening procedure. Such a modelisation could be useful in the development of a rational screening policy.

  8. Beta blockers and the sensitivity of the thallium treadmill test

    Energy Technology Data Exchange (ETDEWEB)

    Martin, G.J.; Henkin, R.E.; Scanlon, P.J.

    1987-09-01

    The effect beta blockers (BB) may have on the sensitivity of the thallium treadmill test (Th-TMT) is controversial. The purpose of this study was to test the hypothesis that BB decrease the sensitivity of the Th-TMT. Two hundred three patients over a two-year period were identified who satisfied the following criteria. All had symptom-limited upright treadmill exercise tests with stress and redistribution thallium imaging, as well as coronary angiography within two months of the Th-TMT. Of 58 patients with CAD not on BB, 52 had an abnormal Th-TMT scan (sensitivity 90 percent). In comparison, the sensitivity of the Th-TMT scan in the 88 patients with CAD receiving BB was 76 percent (p less than 0.05). We conclude that BB may significantly decrease the sensitivity of the Th-TMT. Physicians should fully appreciate the higher false negative rate (24 vs 10 percent) for patients on BB and consider cautious withdrawal prior to diagnostic studies.

  9. LLNL Small-Scale Friction sensitivity (BAM) Test

    Energy Technology Data Exchange (ETDEWEB)

    Simpson, L.R.; Foltz, M.F.

    1996-06-01

    Small-scale safety testing of explosives, propellants and other energetic materials, is done to determine their sensitivity to various stimuli including friction, static spark, and impact. Testing is done to discover potential handling problems for either newly synthesized materials of unknown behavior, or materials that have been stored for long periods of time. This report describes the existing {open_quotes}BAM{close_quotes} Small-Scale Friction Test, and the methods used to determine the friction sensitivity pertinent to handling energetic materials. The accumulated data for the materials tested is not listed here - that information is in a database. Included is, however, a short list of (1) materials that had an unusual response, and (2), a few {open_quotes}standard{close_quotes} materials representing the range of typical responses usually seen.

  10. Hair dye dermatitis and p-phenylenediamine contact sensitivity: A preliminary report

    Directory of Open Access Journals (Sweden)

    Mrinal Gupta

    2015-01-01

    Full Text Available Background: The contact allergic reactions from p-phenylenediamine (PPD in hair dyes vary from mild contact dermatitis to severe life- threatening events (angioedema, bronchospasm, asthma, renal impairment. Objectives: To study the clinical patterns and PPD contact sensitivity in patients with hair-dye dermatitis. Materials and Methods: Eighty (M: F 47:33 consecutive patients aged between 18 and 74 years suspected to have contact allergy from hair dye were studied by patch testing with Indian Standard Series including p-phenylenediamine (PPD, 1.0% pet. Results: 54 Fifty-four (M: F 21:33 patients showed positive patch tests from PPD. Eight of these patients also showed positive patch test reaction from fragrance mix, thiuram mix, paraben mix, or colophony. Fifty-seven (71% patients affected were aged older than 40 years. The duration of dermatitis varied from 1 year with exacerbation following hair coloring. Forty-nine patients had dermatitis of scalp and/or scalp margins and 23 patients had face and neck dermatitis. Periorbital dermatitis, chronic actinic dermatitis, and erythema multiforme-like lesions were seen in 4, 2, and 1 patients, respectively. Conclusions: Hair dyes and PPD constitute a significant cause of contact dermatitis. There is an urgent need for creating consumer awareness regarding hair-dyes contact sensitivity and the significance of performing sensitivity testing prior to actual use.

  11. New test and analysis of position-sensitive-silicon-detector

    Institute of Scientific and Technical Information of China (English)

    FENG Lang; GE Vu-Cheng; WANG He; FAN Feng-Ying; QIAO Rui; LU Fei; SONG Yu-Shou; ZHENG Tao; YE Yan-Lin

    2009-01-01

    We have tested and analyzed the properties of two-dimensional Position-Sensitive-silicon-Detector (PSD) with new integrated preamplifiers.The test demonstrates that the best position resolution for 5.5 MeV α particles is 1.7 mm (FWHM),and the best energy resolution is 2.1%,which are notably better than the previously reported results.A scaling formula is introduced to make the absolute position calibration.

  12. Cooling via one hand improves physical performance in heat-sensitive individuals with Multiple Sclerosis: A preliminary study

    Directory of Open Access Journals (Sweden)

    Murray Julie

    2008-05-01

    Full Text Available Abstract Background Many individuals afflicted with multiple sclerosis (MS experience a transient worsening of symptoms when body temperature increases due to ambient conditions or physical activity. Resulting symptom exacerbations can limit performance. We hypothesized that extraction of heat from the body through the subcutaneous retia venosa that underlie the palmar surfaces of the hands would reduce exercise-related heat stress and thereby increase the physical performance capacity of heat-sensitive individuals with MS. Methods Ten ambulatory MS patients completed one or more randomized paired trials of walking on a treadmill in a temperate environment with and without cooling. Stop criteria were symptom exacerbation and subjective fatigue. The cooling treatment entailed inserting one hand into a rigid chamber through an elastic sleeve that formed an airtight seal around the wrist. A small vacuum pump created a -40 mm Hg subatmospheric pressure enviinside the chamber where the palmar surface of the hand rested on a metal surface maintained at 18–22°C. During the treatment trials, the device was suspended from above the treadmill on a bungee cord so the subjects could comfortably keep a hand in the device without having to bear its weight while walking on the treadmill. Results When the trials were grouped by treatment only, cooling treatment increased exercise durations by 33% (43.6 ± 17.1 min with treatment vs. 32.8 ± 10.9 min. without treatment, mean ± SD, p -6, paired t-test, n = 26. When the average values were calculated for the subjects who performed multiple trials before the treatment group results were compared, cooling treatment increased exercise duration by 35% (42.8 ± 16.4 min with treatment vs. 31.7 ± 9.8 min. without treatment, mean ± SD, p Conclusion These preliminary results suggest that utilization of the heat transfer capacity of the non-hairy skin surfaces can enable temperature-sensitive individuals with MS to

  13. On the use of sensitivity tests in seismic tomography

    NARCIS (Netherlands)

    Rawlinson, N.; Spakman, W.|info:eu-repo/dai/nl/074103164

    2016-01-01

    Sensitivity analysis with synthetic models is widely used in seismic tomography as a means for assessing the spatial resolution of solutions produced by, in most cases, linear or iterative nonlinear inversion schemes. The most common type of synthetic reconstruction test is the so-called checkerboar

  14. On the use of sensitivity tests in seismic tomography

    NARCIS (Netherlands)

    Rawlinson, N.; Spakman, W.|info:eu-repo/dai/nl/074103164

    2016-01-01

    Sensitivity analysis with synthetic models is widely used in seismic tomography as a means for assessing the spatial resolution of solutions produced by, in most cases, linear or iterative nonlinear inversion schemes. The most common type of synthetic reconstruction test is the so-called

  15. On the use of sensitivity tests in seismic tomography

    NARCIS (Netherlands)

    Rawlinson, N.; Spakman, W.

    2016-01-01

    Sensitivity analysis with synthetic models is widely used in seismic tomography as a means for assessing the spatial resolution of solutions produced by, in most cases, linear or iterative nonlinear inversion schemes. The most common type of synthetic reconstruction test is the so-called checkerboar

  16. Design and preliminary test of precision segment positioning actuator for the California Extremely Large Telescope

    Science.gov (United States)

    Lorell, Kenneth R.; Aubrun, Jean-Noel; Clappier, Robert R.; Shelef, Ben; Shelef, Gad

    2003-01-01

    In order for the California Extremely Large Telescope (CELT) to achieve the required optical performance, each of its 1000 primary mirror segments must be positioned relative to adjacent segments with nanometer-level accuracy. This can be accomplished using three actuators for each segment to actively control the segment in tip, tilt, and piston. The Keck telescopes utilize a segmented primary mirror similar to CELT employing a highly successful actuator design. However, because of its size and the shear number of actuators (3000 vs. 108 for Keck), CELT will require a different design. Sensitivity to wind loads and structural vibrations, the large dynamic range, low operating power, and extremely reliable operation, all achieved at an affordable unit cost, are the most demanding design requirements. This paper examines four actuator concepts and presents a trade-off between them. The concept that best met the CELT requirements is described along with an analysis of its performance. The concept is based on techniques that achieve the required accuracy while providing a substantial amount of vibration attenuation and damping. A prototype actuator has been built to validate this concept. Preliminary tests confirm predicted behavior and future tests will establish a sound baseline for final design and production.

  17. Preliminary Test Estimators and Phi-divergence Measures in Pooling Binomial Data

    Directory of Open Access Journals (Sweden)

    N. Martin

    2012-07-01

    Full Text Available Two independent random samples are drawn from two Binomial populations with parameters theta1 and  theta2 respectively. Ahmed (1991 considered a preliminary test estimator based on maximum likelihood estimator for estimating theta1 when it is suspected that theta1=theta2.  In this paper we combine minimum phi-divergence estimators as well as phi-divergence test statistics in order to define a preliminary phi-divergence test estimators. These new estimators are compared with the classical estimator as well as the pooled estimator.

  18. Preliminary Options Assessment of Versatile Irradiation Test Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Sen, Ramazan Sonat [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2017-01-01

    The objective of this report is to summarize the work undertaken at INL from April 2016 to January 2017 and aimed at analyzing some options for designing and building a versatile test reactor; the scope of work was agreed upon with DOE-NE. Section 2 presents some results related to KNK II and PRISM Mod A. Section 3 presents some alternatives to the VCTR presented in [ ] as well as a neutronic parametric study to assess the minimum power requirement needed for a 235U metal fueled fast test reactor capable to generate a fast (>100 keV) flux of 4.0 x 1015 n /cm2-s at the test location. Section 4 presents some results regarding a fundamental characteristic of test reactors, namely displacement per atom (dpa) in test samples. Section 5 presents the INL assessment of the ANL fast test reactor design FASTER. Section 6 presents a summary.

  19. ADDITIVE TESTING FOR IMPROVED SULFUR RETENTION: PRELIMINARY REPORT

    Energy Technology Data Exchange (ETDEWEB)

    Amoroso, J.; Fox, K.

    2011-09-07

    The Savannah River National Laboratory is collaborating with Alfred University to evaluate the potential for additives in borosilicate glass to improve sulfur retention. This preliminary report provides further background on the incorporation of sulfur in glass and outlines the experiments that are being performed by the collaborators. A simulated waste glass composition has been selected for the experimental studies. The first phase of experimental work will evaluate the impacts of BaO, PbO, and V{sub 2}O{sub 5} at concentrations of 1.0, 2.0, and 5.0 wt % on sulfate retention in simulated high level waste borosilicate glass. The second phase of experimental work will evaluate the effects of time at the melt temperature on sulfur retention. The resulting samples will be characterized to determine the amount of sulfur remaining as well as to identify the formation of any crystalline phases. The results will be used to guide the future selection of frits and glass forming chemicals in vitrifying Department of Energy wastes containing high sulfur concentrations.

  20. Radiation Testing on State-of-the-Art CMOS: Challenges, Plans, and Preliminary Results

    Science.gov (United States)

    LaBel, Kenneth A.; Cohn, Lewis M.

    2009-01-01

    At GOMAC 2007 and 2008, we discussed a variety of challenges for radiation testing of modern semiconductor devices and technologies [1, 2]. In this presentation, we provide more specific details in this on-going investigation focusing on out-of-the-box lessons observed for providing radiation effects assurances as well as preliminary test results.

  1. Interteaching and the Testing Effect: A Preliminary Analysis

    Science.gov (United States)

    Lambert, Tonya; Saville, Bryan K.

    2012-01-01

    In a number of studies, interteaching has produced better student-learning outcomes than traditional teaching methods. Little research, however, has examined ways to make interteaching more effective. Research on the testing effect suggests that frequent testing may improve performance. Thus, including postdiscussion quizzes as a part of…

  2. Preliminary test of effects of cognitive ability, experience, and teaching methods on Verbal Analogy Test scores.

    Science.gov (United States)

    Rosenberg, D; Willson-Quayle, A; Pasnak, R

    2000-06-01

    The methods from which one can choose when preparing for the GRE Verbal Analogies include books, software, audiotapes, and formal classroom instruction. What teaching method will work best for a given individual? To begin the search for an answer, Gray's test of reasoning ability was given to 28 undergraduates who also answered a questionnaire detailing their experience with analogies. They were randomly assigned to teaching conditions ranging from self-directed workbook study to intensive interactive assistance. No teaching method was superior overall, but interactions showed that (1) students who scored worst on the pretest improved the most, (2) those higher in cognitive functioning and experience performed better after intensive interactive assistance, and (3) those lower in both cognitive functioning and experience did significantly better with self-paced workbooks. This preliminary work suggests that it may be profitable to assess the prior experience and reasoning of potential students and adopt the methods for teaching formal operational thought found empirically to be most suitable.

  3. Stressful events and psychological difficulties: testing alternative candidates for sensitivity.

    Science.gov (United States)

    Laceulle, Odilia M; O'Donnell, Kieran; Glover, Vivette; O'Connor, Thomas G; Ormel, Johan; van Aken, Marcel A G; Nederhof, Esther

    2014-02-01

    The current study investigated the longitudinal, reciprocal associations between stressful events and psychological difficulties from early childhood to mid-adolescence. Child age, sex, prenatal maternal anxiety, and difficult temperament were tested as sources of sensitivity, that is, factors that may make children more sensitive to stressful life events. Analyses were based on data from 10,417 children from a prospective, longitudinal study of child development. At ages 4, 7, 9, 11, and 16 years, stressful events and psychological difficulties were measured. Prenatal anxiety was measured at 32 weeks of gestation and difficult temperament was measured at 6 months. Children exposed to stressful events showed significantly increased psychological difficulties at ages 7 and 11 years; there was consistent evidence of a reciprocal pattern: psychological difficulties predicted stressful events at each stage. Analyses also indicated that the associations between stressful events and psychological difficulties were stronger in girls than in boys. We found no evidence for the hypothesis that prenatal anxiety or difficult temperament increased stress sensitivity, that is, moderated the link between life events and psychological difficulties. The findings extend prior work on stress exposure and psychological difficulties and highlight the need for additional research to investigate sources of sensitivity and the mechanisms that might underlie differences in sensitivity to stressful events.

  4. Preliminary low temperature tests of a digital signal processor

    Science.gov (United States)

    Zebulum, Ricardo S.; Ramesham, Rajeshuni; Stoica, Adrian; Keymeulen, Didier; Daud, Taher; Sekanina, Lukas

    2005-01-01

    This paper describes an initial experiment performed to assess the electrical behavior of the Innovative Integration board containing a Digital Signal Processor (DSP) with its JTAG (Blackhawk) connector at low temperatures. The objective of the experiment is to determine the lowest temperature at which the DSP can operate. The DSP was tested at various low-temperatures and a Genetic Algorithm was used as the DSP test program.

  5. CHALLENGE TESTS WITH LISTERIA MONOCYTOGENES IN SALAMI: PRELIMINARY RESULTS

    Directory of Open Access Journals (Sweden)

    R. Mioni

    2013-02-01

    Full Text Available Challenge tests are the preferable methodology to study the behaviour of Listeria monocytogenes on ready to eat foods, according to Regulation (EC 2073/2005. Challenge testing using L. monocytogenes in seasoned salami from different food business operators showed, after seasoning of the product, a count reduction of the inoculated organisms without any further growth of the pathogen; however differences of L. monocytogenes behaviour could be observed according to different production protocols.

  6. Testing the Perturbation Sensitivity of Abortion-Crime Regressions

    OpenAIRE

    2012-01-01

    The hypothesis that the legalisation of abortion contributed significantly to the reduction of crime in the United States in 1990s is one of the most prominent ideas from the recent 'economics-made-fun' movement sparked by the book Freakonomics. This paper expands on the existing literature about the computational stability of abortion-crime regressions by testing the sensitivity of coefficients' estimates to small amounts of data perturbation. In contrast to previous studies, we use a new da...

  7. Putting Google Scholar to the Test: A Preliminary Study

    Science.gov (United States)

    Robinson, Mary L.; Wusteman, Judith

    2007-01-01

    Purpose: To describe a small-scale quantitative evaluation of the scholarly information search engine, Google Scholar. Design/methodology/approach: Google Scholar's ability to retrieve scholarly information was compared to that of three popular search engines: Ask.com, Google and Yahoo! Test queries were presented to all four search engines and…

  8. On Designing Construct Driven Situational Judgment Tests: Some Preliminary Recommendations

    Science.gov (United States)

    Guenole, Nigel; Chernyshenko, Oleksandr S.; Weekly, Jeff

    2017-01-01

    Situational judgment tests (SJTs) are widely agreed to be a measurement technique. It is also widely agreed that SJTs are a questionable methodological choice for measurement of psychological constructs, such as behavioral competencies, due to a lack of evidence supporting appropriate factor structures and high internal consistencies.…

  9. Modeling and Testing of EVs - Preliminary Study and Laboratory Development

    DEFF Research Database (Denmark)

    Yang, Guang-Ya; Marra, Francesco; Nielsen, Arne Hejde;

    2010-01-01

    Electric vehicles (EVs) are expected to play a key role in the future energy management system to stabilize both supply and consumption with the presence of high penetration of renewable generation. A reasonably accurate model of battery is a key element for the study of EVs behavior and the grid...... tests, followed by the suggestions towards a feasible battery model for further studies....

  10. Preliminary tests of a damaged ship for CFD validation

    Directory of Open Access Journals (Sweden)

    Sungkyun Lee

    2012-06-01

    Full Text Available One of the most critical issues in naval architecture these days is the operational safety. Among many factors to be considered for higher safety level requirements, the hull stability in intact and damaged conditions is the first to ensure for both commercial and military vessels. Unlike the intact stability cases, the assessment of the damaged ship stability is very complicated physical phenomena. Therefore it is widely acknowledged that computational fluid dynamics (CFD methods are one of most feasible approaches. In order to develop better CFD methods for damaged ship stability assessment, it is essential to perform well-designed model tests and to build a database for CFD validation. In the present study, free roll decay tests in calm water with both intact and damaged ships were performed and six degree-of-freedom (6DOF motion responses of intact ship in regular waves were measured. Through the free roll decay tests, the effects of the flooding water on the roll decay motion of a ship were investigated. Through the model tests in regular waves, the database that provides 6DOF motion responses of intact ship was established.

  11. Study and Preliminary Analysis of Test of Aerosol Migration Mechanism

    Institute of Scientific and Technical Information of China (English)

    CHEN; Lin-lin; SUN; Xue-ting; WEI; Yan-song

    2015-01-01

    TAMM(test of aerosol migration mechanism)is one of the important aspects of Studies on Migration Mechanism of the Source Term under Severe Accident,which is a significant research of the National Large Advanced PWR Research Program.The main task researches the

  12. Preliminary Results of Breakwater Round-Head Tests

    DEFF Research Database (Denmark)

    Burcharth, H. F.; Liu, Z.

    1995-01-01

    The rational design diagram for Dolos armour should incorporate both the hydraulic stability and the structural integrity. The previous tests performed by Aalborg University (AU) made available such design diagram for the trunk of Dolos breakwater without superstructures (Burcharth et al. 1992...

  13. In vitro tests to evaluate immunotoxicity: A preliminary study.

    NARCIS (Netherlands)

    Carfi', M; Gennari, A; Malerba, I; Corsini, E; Pallardy, M; Pieters, R; Loveren, Henk van; Vohr, H W; Hartung, T; Gribaldo, L

    2007-01-01

    The implementation of Registration, Evaluation and Authorisation of new and existing Chemicals (REACH) will increase the number of laboratory animals used, if alternative methods will not be available. In the meantime, REACH promotes the use of in vitro tests and, therefore, a set of appropriated al

  14. Semantic Verbal Fluency test in dementia: Preliminary retrospective analysis

    Directory of Open Access Journals (Sweden)

    Marcos Lopes

    Full Text Available Abstract The Semantic Verbal Fluency (SVF test entails the generation of words from a given category within a pre-set time of 60 seconds. Objectives: To verify whether socio-demographic and clinical data of individuals with dementia correlate with the performance on the SVF test and to ascertain whether differences among the criteria of number of answers, clusters and data spread over the intervals, predict clinical results. Methods: This was a retrospective study of 49 charts of demented patients classified according to the Clinical Dementia Rating (CDR scale. We correlated education, age and gender, as well as CDR and Mini-Mental State Exam (MMSE scores with the number of answers, clustering and switching distributed over four 15-second intervals on the SVF test. Results: The correlation between number of answers and quartiles was weak (r=0.407, p=0.004; r=0.484, p<0.001 but correlation between the number of clusters and responses was strong (r=0.883, p<0.001. The number of items on the SVF was statistically significant with MMSE score (p=0.01 and there was a tendency for significance on the CDR (p=0.06. The results indicated little activity regarding what we propose to call cluster recalling in the two groups. Discussion: The SVF test, using number of items generated, was found to be more effective than classic screening tests in terms of speed and ease of application in patients with CDR 2 and 3.

  15. Preliminary Results of Testing of Flow Effects on Evaporator Scaling

    Energy Technology Data Exchange (ETDEWEB)

    Hu, M.Z.

    2002-02-15

    This investigation has focused on the effects of fluid flow on solids deposition from solutions that simulate the feed to the 2H evaporator at the Savannah River Site. Literature studies indicate that the fluid flow (or shear) affects particle-particle and particle-surface interactions and thus the phenomena of particle aggregation in solution and particle deposition (i.e., scale formation) onto solid surfaces. Experimental tests were conducted with two configurations: (1) using a rheometer to provide controlled shear conditions and (2) using controlled flow of reactive solution through samples of stainless steel tubing. All tests were conducted at 80 C and at high silicon and aluminum concentrations, 0.133 M each, in solutions containing 4 M sodium hydroxide and 1 A4 each of sodium nitrate and sodium nitrite. Two findings from these experiments are important for consideration in developing approaches for reducing or eliminating evaporator scaling problems: (1) The rheometer tests suggested that for the conditions studied, maximum solids deposition occurs at a moderate shear rate, approximately 12 s{sup -1}. That value is expected to be on the order of shear rates that will occur in various parts of the evaporator system; for instance, a 6 gal/min single-phase liquid flow through the 2-in. lift or gravity drain lines would result in a shear rate of approximately 16 s{sup -1}. These results imply that engineering approaches aimed at reducing deposits through increased mixing would need to generate shear near all surfaces significantly greater than 12 s{sup -1}. However, further testing is needed to set a target value for shear that is applicable to evaporator operation. This is because the measured trend is not statistically significant at the 95% confidence interval due to variability in the results. In addition, testing at higher temperatures and lower concentrations of aluminum and silicon would more accurately represent conditions in the evaporator. Without

  16. Flight Test 4 Preliminary Results: NASA Ames SSI

    Science.gov (United States)

    Isaacson, Doug; Gong, Chester; Reardon, Scott; Santiago, Confesor

    2016-01-01

    Realization of the expected proliferation of Unmanned Aircraft System (UAS) operations in the National Airspace System (NAS) depends on the development and validation of performance standards for UAS Detect and Avoid (DAA) Systems. The RTCA Special Committee 228 is charged with leading the development of draft Minimum Operational Performance Standards (MOPS) for UAS DAA Systems. NASA, as a participating member of RTCA SC-228 is committed to supporting the development and validation of draft requirements as well as the safety substantiation and end-to-end assessment of DAA system performance. The Unmanned Aircraft System (UAS) Integration into the National Airspace System (NAS) Project conducted flight test program, referred to as Flight Test 4, at Armstrong Flight Research Center from April -June 2016. Part of the test flights were dedicated to the NASA Ames-developed Detect and Avoid (DAA) System referred to as JADEM (Java Architecture for DAA Extensibility and Modeling). The encounter scenarios, which involved NASA's Ikhana UAS and a manned intruder aircraft, were designed to collect data on DAA system performance in real-world conditions and uncertainties with four different surveillance sensor systems. Flight test 4 has four objectives: (1) validate DAA requirements in stressing cases that drive MOPS requirements, including: high-speed cooperative intruder, low-speed non-cooperative intruder, high vertical closure rate encounter, and Mode CS-only intruder (i.e. without ADS-B), (2) validate TCASDAA alerting and guidance interoperability concept in the presence of realistic sensor, tracking and navigational errors and in multiple-intruder encounters against both cooperative and non-cooperative intruders, (3) validate Well Clear Recovery guidance in the presence of realistic sensor, tracking and navigational errors, and (4) validate DAA alerting and guidance requirements in the presence of realistic sensor, tracking and navigational errors. The results will be

  17. Analysis of sensitivity and errors in Maglev vibration test system

    Institute of Scientific and Technical Information of China (English)

    JIANG; Dong; LIU; Xukun; WANG; Deyu; YANG; Jiaxiang

    2016-01-01

    In order to improve work performance of M aglev vibration test systems,the relationships of operating parameters between different components and system were researched. The working principle of photoelectric displacement sensor was analyzed. The relationship between displacement of transducer and the infrared light area received by sensor was given. The method of expanding the dynamic range of vibrator was proposed,which makes dynamic range of Maglev vibrator doubled. By increasing the amplification of the amplifier,the sensitive photoelectric displacement sensor can be maintained. Two modes of operation of the controller were analyzed. Bilateral work of vibration test system designed can further improve the stability of the system.An object vibration was measured by Maglev vibration test system designed when different vibration exciter frequencies were loaded. Experiments showthat the output frequency measured by Maglev vibration test system and loaded are the same. Finally,the errors of test system were analyzed. These errors of vibration test system designed can meet the requirements of application. The results laid the foundation for the practical application of magnetic levitation vibration test system.

  18. Oblique impact sensitivity of explosives: The skid test the snatch friction sensitivity test. Quarterly report, April--June 1964

    Energy Technology Data Exchange (ETDEWEB)

    Akst, I.B.; Washburn, B.M.; Rigdon, J.K.

    1997-09-01

    The oblique impact sensitivity of UK-UK-simulated HMX in 85 to 90% formulation with Viton is not enough lower, if any, to encourage richer formulations or change to Bridgewater processes for this reason alone. Fifty-pound cyclotol 75/25 hemispheres gave moderate reactions (No. 4) as low as 3.5 foot (14{degrees}); lower tests have not been performed yet. {open_quotes}Reduced-H.E.{close_quotes} pieces of PBX 9404, 2, 3, 4, and 5 inches thick, respectively, were tested at 1.75 foot (14{degrees}) resulting in a 6 reaction for the 5 inches thick piece while the remaining three pieces gave 0 reactions.

  19. Direct Sensitivity Test of the MB/BacT System

    Directory of Open Access Journals (Sweden)

    Barreto Angela Maria Werneck

    2002-01-01

    Full Text Available In order to evaluate the direct-method test of sensitivity to drugs used in the principal tuberculosis treatment regimes, in the Organon Teknika MB/BacT system, we tested 50 sputum samples positive to microscopy taken from patients with pulmonary tuberculosis and with clinical indications for an antibiogram, admitted sequentially for examination during the routine of the reference laboratory. The material was treated v/v with 23% trisodium phosphate solution, incubated for 24 h at 35°C, and neutralized v/v with 20% monosodium phosphate solution. The material was then centrifuged and the sediment inoculated into flasks containing Rifampin - 2 µg/ml, Isoniazid - 0.2 µg/ml, Pyrazinamide - 100 µg/ml, Ethambutol - 2.5 µg/ml, Ethionamide - 1.25 µg/ml, and Streptomycin - 2 µg/ml. The tests were evaluated using the indirect method in the BACTEC 460 TB (Becton Dickinson system as the gold standard. The results showed that the Rifampin test performed best, i.e., 100% sensitivity at 95% Confidence Interval (82.2-100 and 100% specificity at 95% Confidence Interval (84.5-100, followed by Isoniazid and Pyrazinamide. In this experiment, 92% of the materials showed a final reading in 30 days; this period represents the time for primary isolation as well as the results of the sensitivity profile, and is within Centers for Disease Control and Prevention recommendations regarding time for performance of the antibiogram. The inoculated flasks showed no contamination during the experiment. The MB/BacT is shown to be a reliable, rapid, fully automated nonradiometric system for the tuberculosis antibiogram.

  20. Preliminary operational results of the industrial process heat field tests

    Energy Technology Data Exchange (ETDEWEB)

    Kutscher, C.; Davenport, R.

    1980-04-01

    There are currently six DOE-funded solar industrial process heat (IPH) field tests which have been operational for one year or longer. These are all low temperature first generation projects which supply heat at temperatures below 100/sup 0/C - three hot water and three hot air. During the 1979 calendar year, personnel from the Solar Energy Research Institute (SERI) visited all of these sites; the performance and cost results obtained for each project and the operational problems encountered at each site are discussed.

  1. Preliminary results of the round-robin testing of F82H

    Energy Technology Data Exchange (ETDEWEB)

    Shiba, K.; Yamanouchi, N.; Tohyama, A.

    1996-10-01

    Preliminary results of metallurgical, physical and mechanical properties of low activation ferritic steel F82H (IEA heat) were obtained in the round-robin test in Japan. The properties of IEA heat F82H were almost the same as the original F82H.

  2. Preliminary results of a proficiency testing of industrial CT scanners using small polymer items

    DEFF Research Database (Denmark)

    Angel, Jais Andreas Breusch; Cantatore, Angela; De Chiffre, Leonardo

    2012-01-01

    This work presents preliminary results concerning a proficiency testing for intercomparison of industrial CT scanners. Two audit items, similar to common industrial parts, were selected for circulation. The two items were a single polymer complex geometry part and a simple geometry item made of two...

  3. Preliminary Investigation of the 1991 Medical College Admission Test Factor Structure.

    Science.gov (United States)

    Li, Weichang; Mitchell, Karen J.

    A substantially revised Medical College Admission Test (MCAT) was introduced in spring 1991. The new examination is designed to assess critical thinking skills, basic concepts and problem solving facility in science, and writing skills. This paper reports preliminary findings on the factor structure of the revised MCAT, which consists of four…

  4. Sizing and preliminary hardware testing of solar powered UAV

    Directory of Open Access Journals (Sweden)

    S. Jashnani

    2013-12-01

    Full Text Available Integrating solar energy into modern aircraft technology has been a topic of interest and has received a lot of attention from researchers over the last two decades. A few among the many potential applications of this technology are the possibility of continuous self sustained flight for purposes such as information relay, surveillance and monitoring. This paper discusses the altitude and payload mass, as independent parameters, and their influence on the size and design of the aircraft. To estimate available solar power, two different models have been presented; one for low altitudes and the other for high altitudes. An engineering ground model was built to simulate the power and propulsion system over 24 h of continuous operation. The paper presents data from tests performed till date and lessons learnt while dealing with the construction of the engineering ground model as well as changes that can be made to improve the design.

  5. Preliminary Scaling Estimate for Select Small Scale Mixing Demonstration Tests

    Energy Technology Data Exchange (ETDEWEB)

    Wells, Beric E.; Fort, James A.; Gauglitz, Phillip A.; Rector, David R.; Schonewill, Philip P.

    2013-09-12

    The Hanford Site double-shell tank (DST) system provides the staging location for waste that will be transferred to the Hanford Tank Waste Treatment and Immobilization Plant (WTP). Specific WTP acceptance criteria for waste feed delivery describe the physical and chemical characteristics of the waste that must be met before the waste is transferred from the DSTs to the WTP. One of the more challenging requirements relates to the sampling and characterization of the undissolved solids (UDS) in a waste feed DST because the waste contains solid particles that settle and their concentration and relative proportion can change during the transfer of the waste in individual batches. A key uncertainty in the waste feed delivery system is the potential variation in UDS transferred in individual batches in comparison to an initial sample used for evaluating the acceptance criteria. To address this uncertainty, a number of small-scale mixing tests have been conducted as part of Washington River Protection Solutions’ Small Scale Mixing Demonstration (SSMD) project to determine the performance of the DST mixing and sampling systems.

  6. Preliminary Failure Modes and Effects Analysis of the US DCLL Test Blanket Module

    Energy Technology Data Exchange (ETDEWEB)

    Lee C. Cadwallader

    2007-08-01

    This report presents the results of a preliminary failure modes and effects analysis (FMEA) of a small tritium-breeding test blanket module design for the International Thermonuclear Experimental Reactor. The FMEA was quantified with “generic” component failure rate data, and the failure events are binned into postulated initiating event families and frequency categories for safety assessment. An appendix to this report contains repair time data to support an occupational radiation exposure assessment for test blanket module maintenance.

  7. Preliminary Failure Modes and Effects Analysis of the US DCLL Test Blanket Module

    Energy Technology Data Exchange (ETDEWEB)

    Lee C. Cadwallader

    2010-06-01

    This report presents the results of a preliminary failure modes and effects analysis (FMEA) of a small tritium-breeding test blanket module design for the International Thermonuclear Experimental Reactor. The FMEA was quantified with “generic” component failure rate data, and the failure events are binned into postulated initiating event families and frequency categories for safety assessment. An appendix to this report contains repair time data to support an occupational radiation exposure assessment for test blanket module maintenance.

  8. Sensitivity analysis, calibration, and testing of a distributed hydrological model using error-based weighting and one objective function

    Science.gov (United States)

    Foglia, L.; Hill, Mary C.; Mehl, Steffen W.; Burlando, P.

    2009-01-01

    We evaluate the utility of three interrelated means of using data to calibrate the fully distributed rainfall-runoff model TOPKAPI as applied to the Maggia Valley drainage area in Switzerland. The use of error-based weighting of observation and prior information data, local sensitivity analysis, and single-objective function nonlinear regression provides quantitative evaluation of sensitivity of the 35 model parameters to the data, identification of data types most important to the calibration, and identification of correlations among parameters that contribute to nonuniqueness. Sensitivity analysis required only 71 model runs, and regression required about 50 model runs. The approach presented appears to be ideal for evaluation of models with long run times or as a preliminary step to more computationally demanding methods. The statistics used include composite scaled sensitivities, parameter correlation coefficients, leverage, Cook's D, and DFBETAS. Tests suggest predictive ability of the calibrated model typical of hydrologic models.

  9. Sensitivity of The Dynamic Visual Acuity Test To Sensorimotor Change

    Science.gov (United States)

    Cohen, Helen; Bloomberg, Jacob; Elizalde, Elizabeth; Fregia, Melody

    1999-01-01

    Post-flight astronauts, acutely post-vestibular nerve section patients, and patients with severe chronic bilateral vestibular deficits have oscillopsia caused by reduced vestibulocular reflex gains and decreased postural stability. Therefore, as previous work has shown, a test of dynamic visual acuity (DVA), in which the subject must read numbers from a computer screen while standing still or walking in place provides a composite measure of sensorimotor integration. This measure may be useful for determining the level of recovery, post-flight, post-operatively, or after vestibular rehabilitation. To determine the sensitivity of DVA to change in impaired populations we have tested patients with acoustic neuromas before and during the first post-operative week after resection of the tumors, and with bilaterally labyrinthine deficient subjects before and after six weeks of balance rehabilitation therapy.

  10. State of the art in non-animal approaches for skin sensitization testing: from individual test methods towards testing strategies.

    Science.gov (United States)

    Ezendam, Janine; Braakhuis, Hedwig M; Vandebriel, Rob J

    2016-12-01

    The hazard assessment of skin sensitizers relies mainly on animal testing, but much progress is made in the development, validation and regulatory acceptance and implementation of non-animal predictive approaches. In this review, we provide an update on the available computational tools and animal-free test methods for the prediction of skin sensitization hazard. These individual test methods address mostly one mechanistic step of the process of skin sensitization induction. The adverse outcome pathway (AOP) for skin sensitization describes the key events (KEs) that lead to skin sensitization. In our review, we have clustered the available test methods according to the KE they inform: the molecular initiating event (MIE/KE1)-protein binding, KE2-keratinocyte activation, KE3-dendritic cell activation and KE4-T cell activation and proliferation. In recent years, most progress has been made in the development and validation of in vitro assays that address KE2 and KE3. No standardized in vitro assays for T cell activation are available; thus, KE4 cannot be measured in vitro. Three non-animal test methods, addressing either the MIE, KE2 or KE3, are accepted as OECD test guidelines, and this has accelerated the development of integrated or defined approaches for testing and assessment (e.g. testing strategies). The majority of these approaches are mechanism-based, since they combine results from multiple test methods and/or computational tools that address different KEs of the AOP to estimate skin sensitization potential and sometimes potency. Other approaches are based on statistical tools. Until now, eleven different testing strategies have been published, the majority using the same individual information sources. Our review shows that some of the defined approaches to testing and assessment are able to accurately predict skin sensitization hazard, sometimes even more accurate than the currently used animal test. A few defined approaches are developed to provide an

  11. Free Fall tests for the qualification of Ultra sensitive accelerometers for space missions

    Science.gov (United States)

    Françoise, Liorzou; Pierre, Marque Jean; Santos Rodrigues, Manuel

    ONERA is developing since a long time accelerometers for space applications in the field of Earth Observations and Fundamental Physics. The more recent examples are the accelerom-eters embarked on the ESA GOCE mission launched in March 2009, dedicated to the Earth precise gravity field mapping, and the accelerometers of the CNES MICROSCOPE mission dedicated to the in orbit test of the Equivalence Principle. Those Ultra sensitive accelerome-ters are optimised for the space environment and operate over an acceleration range less than 10-6 ms-2 with an outstanding accuracy around 10-12 ms-2Hz1/2. Their testability on ground requires creating a low gravity environment in order to verify their functionalities and partially their performances before their delivery before launch. Free fall tests are the only way to ob-tain such a microgravity environment in representating space conditions. The presentation will show in a first part the results of the free fall test campaigns performed in the 120-meter high ZARM drop tower that have led to the qualification of the GOCE accelerometers. In a second part, it will describe the test plan being conducted to assess the best free-fall environment for the MICROSCOPE accelerometers. In particular, some efforts have been paid by ZARM and ONERA to develop a dedicated "free-flyer"capsule, in order to reduce the residual drag acceleration along the fall. Some results from the preliminary tests performed in preparation to the MICROSCOPE qualification campaign will be also presented.

  12. [Information Concerning Mean Test Scores for the Graduate Management Admission Test (GMAT), Graduate Record Examinations (GRE), Law School Admission Test (LSAT), Preliminary Scholastic Aptitude Test (PSAT), and Scholastic Aptitude Test (SAT) for the National Commission on Excellence in Education.

    Science.gov (United States)

    Solomon, Robert J.

    Data are provided to the National Commission on Excellence in Education on the Graduate Management Admission Test (GMAT), Graduate Record Examinations (GRE), Law School Admission Test (LSAT), Preliminary Scholastic Aptitude Test (PSAT), and Scholastic Aptitude Test (SAT). Statistics are provided on the following: yearly GMAT mean scores 1965-1966…

  13. Odor-Specific Loss of Smell Sensitivity with Age as Revealed by the Specific Sensitivity Test.

    Science.gov (United States)

    Seow, Yi-Xin; Ong, Peter K C; Huang, Dejian

    2016-07-01

    The perception of odor mixtures plays an important role in human food intake, behavior, and emotions. Decline of smell acuity with normal aging could impact food perception and preferences at various ages. However, since the landmark Smell Survey by National Geographic, little has been elucidated on differences in the onset and extent of loss in olfactory sensitivity toward single odorants. Here, using the Specific Sensitivity test, we show the onset and extent of loss in both identification and detection thresholds of odorants with age are odorant-specific. Subjects of Chinese descent in Singapore (186 women, 95 men), aged 21-80 years, were assessed for olfactory sensitivity of 10 odorants from various odor groups. Notably, subjects in their 70s required 179 times concentration of rose-like odorant (2-phenylethanol) than subjects in the 20s, while thresholds for onion-like 2-methyloxolane-3-thiol only differed by 3 times between the age groups. In addition, identification rate for 2-phenylethanol was negatively correlated with age throughout adult life whereas mushroom-like oct-1-en-3-ol was equally identified by subjects across all ages. Our results demonstrated the girth of differentiated olfactory loss due to normal ageing, which potentially affect overall perception and preferences of odor mixtures with age. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  14. Visualization of periventricular collaterals in moyamoya disease with flow-sensitive black-blood magnetic resonance angiography: preliminary experience.

    Science.gov (United States)

    Funaki, Takeshi; Fushimi, Yasutaka; Takahashi, Jun C; Takagi, Yasushi; Araki, Yoshio; Yoshida, Kazumichi; Kikuchi, Takayuki; Miyamoto, Susumu

    2015-01-01

    Fragile abnormal collaterals in moyamoya disease, known as "moyamoya vessels," have rarely been defined. While flow-sensitive black-blood magnetic resonance angiography (FSBB-MRA) is a promising technique for visualizing perforating arteries, as of this writing no other reports exist regarding its application to moyamoya disease. Six adults with moyamoya disease underwent FSBB-MRA. It depicted abnormal collaterals as extended lenticulostriate, thalamic perforating, or choroidal arteries, which were all connected to the medullary or insular artery in the periventricular area and supplied the cortex. This preliminary case series illustrates the potential for FSBB-MRA to reveal abnormal moyamoya vessels, which could be reasonably defined as periventricular collaterals.

  15. A Sensitivity Study for an Evaluation of Input Parameters Effect on a Preliminary Probabilistic Tsunami Hazard Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Rhee, Hyun-Me; Kim, Min Kyu; Choi, In-Kil [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Sheen, Dong-Hoon [Chonnam National University, Gwangju (Korea, Republic of)

    2014-10-15

    The tsunami hazard analysis has been based on the seismic hazard analysis. The seismic hazard analysis has been performed by using the deterministic method and the probabilistic method. To consider the uncertainties in hazard analysis, the probabilistic method has been regarded as attractive approach. The various parameters and their weight are considered by using the logic tree approach in the probabilistic method. The uncertainties of parameters should be suggested by analyzing the sensitivity because the various parameters are used in the hazard analysis. To apply the probabilistic tsunami hazard analysis, the preliminary study for the Ulchin NPP site had been performed. The information on the fault sources which was published by the Atomic Energy Society of Japan (AESJ) had been used in the preliminary study. The tsunami propagation was simulated by using the TSUNAMI{sub 1}.0 which was developed by Japan Nuclear Energy Safety Organization (JNES). The wave parameters have been estimated from the result of tsunami simulation. In this study, the sensitivity analysis for the fault sources which were selected in the previous studies has been performed. To analyze the effect of the parameters, the sensitivity analysis for the E3 fault source which was published by AESJ was performed. The effect of the recurrence interval, the potential maximum magnitude, and the beta were suggested by the sensitivity analysis results. Level of annual exceedance probability has been affected by the recurrence interval.. Wave heights have been influenced by the potential maximum magnitude and the beta. In the future, the sensitivity analysis for the all fault sources in the western part of Japan which were published AESJ would be performed.

  16. Testing the Perturbation Sensitivity of Abortion-Crime Regressions

    Directory of Open Access Journals (Sweden)

    Michał Brzeziński

    2012-06-01

    Full Text Available The hypothesis that the legalisation of abortion contributed significantly to the reduction of crime in the United States in 1990s is one of the most prominent ideas from the recent “economics-made-fun” movement sparked by the book Freakonomics. This paper expands on the existing literature about the computational stability of abortion-crime regressions by testing the sensitivity of coefficients’ estimates to small amounts of data perturbation. In contrast to previous studies, we use a new data set on crime correlates for each of the US states, the original model specifica-tion and estimation methodology, and an improved data perturbation algorithm. We find that the coefficients’ estimates in abortion-crime regressions are not computationally stable and, therefore, are unreliable.

  17. Preliminary report: in-plant safety/relief valve discharge load test, Monticello Plant

    Energy Technology Data Exchange (ETDEWEB)

    Chang, H.C. (comp.)

    1976-12-01

    This preliminary report covers the results of the test program of safety/relief valve (SRV) discharge load phenomena and the effects upon the Mark I primary containment torus structure of the Monticello Nuclear Power Plant. The objectives of the test were to provide a data base for verifying/improving analytical models and to measure the structural response of the torus to SRV discharges. Objectives, instrumentation, and test plan are described. Results of continuing data evaluation will be included in the final report scheduled for publication later in 1977.

  18. Preliminary environmental analysis of a geopressured-geothermal test well in Brazoria County, Texas

    Energy Technology Data Exchange (ETDEWEB)

    White, W.A.; McGraw, M.; Gustavson, T.C.; Meriwether, J.

    1977-11-16

    Preliminary environmental data, including current land use, substrate lithology, soils, natural hazards, water resources, biological assemblages, meteorological data, and regulatory considerations have been collected and analyzed for approximately 150 km/sup 2/ of land near Chocolate Bayou, Brazoria County, Texas, in which a geopressured-geothermal test well is to be drilled in the fall of 1977. The study was designed to establish an environmental data base and to determine, within spatial constraints set by subsurface reservoir conditions, environmentally suitable sites for the proposed well. Preliminary analyses of data revealed the eed for focusing on the following areas: potential for subsidence and fault activation, susceptibility of test well and support facilities to fresh- and salt-water flooding, possible effects of produced saline waters on biological assemblages and groundwaer resources, distribution of expansive soils, and effect of drilling and associated support activities on known archeological-cultural resources.

  19. Preliminary Study of Position-Sensitive Large-Area Radiation Portal Monitor

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Chang Hwy; Kim, Hyunok; Moon, Myung Kook [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Kim, Jongyul [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of); Park, Jong Won; Lim, Yong Kon [Korea Institute of Ocean Science and Technology, Daejeon (Korea, Republic of)

    2013-10-15

    An RPM, which is a passive inspection method, is a system for monitoring the movement of radioactive materials at an airport, seaport, border, etc. To detect a γ-ray, an RPM using the plastic scintillator is generally used. The method of γ-ray detection using an RPM with a plastic scintillator is to measure lights generated by an incident γ-ray in the scintillator. Generally, a large-area RPM uses one or two photomultiplier tubes (PMT) for light collection. However, in this study, we developed a 4-ch RPM that can measure the radiation signal using 4 PMTs. The reason for using 4 PMTs is to calculate the position of the radiation source. In addition, we developed an electric device for acquisition of a 4-ch output signal at the same time. To estimate the performance of the developed RPM, we performed an RPM test using a {sup 60}Co γ-ray check source. In this study, we performed the development of a 4-ch RPM. The major function of the typical RPM is to measure the radiation. However, we developed a position-sensitive 4-ch RPM, which can be used to measure the location of the radiation source, as well as the radiation measurement, at the same time. In the future, we plan to develop an algorithm for a position detection of the radiation. In addition, an algorithm will be applied to an RPM.

  20. On the use of sensitivity tests in seismic tomography

    Science.gov (United States)

    Rawlinson, N.; Spakman, W.

    2016-05-01

    Sensitivity analysis with synthetic models is widely used in seismic tomography as a means for assessing the spatial resolution of solutions produced by, in most cases, linear or iterative nonlinear inversion schemes. The most common type of synthetic reconstruction test is the so-called checkerboard resolution test in which the synthetic model comprises an alternating pattern of higher and lower wave speed (or some other seismic property such as attenuation) in 2-D or 3-D. Although originally introduced for application to large inverse problems for which formal resolution and covariance could not be computed, these tests have achieved popularity, even when resolution and covariance can be computed, by virtue of being simple to implement and providing rapid and intuitive insight into the reliability of the recovered model. However, checkerboard tests have a number of potential drawbacks, including (1) only providing indirect evidence of quantitative measures of reliability such as resolution and uncertainty, (2) giving a potentially misleading impression of the range of scale-lengths that can be resolved, and (3) not giving a true picture of the structural distortion or smearing that can be caused by the data coverage. The widespread use of synthetic reconstruction tests in seismic tomography is likely to continue for some time yet, so it is important to implement best practice where possible. The goal of this paper is to develop the underlying theory and carry out a series of numerical experiments in order to establish best practice and identify some common pitfalls. Based on our findings, we recommend (1) the use of a discrete spike test involving a sparse distribution of spikes, rather than the use of the conventional tightly spaced checkerboard; (2) using data coverage (e.g. ray-path geometry) inherited from the model constrained by the observations (i.e. the same forward operator or matrix), rather than the data coverage obtained by solving the forward problem

  1. Test for Nonlinear Input Output Relations in SISO Systems by Preliminary Data Analysis

    DEFF Research Database (Denmark)

    Knudsen, Torben

    2000-01-01

    This paper discusses and develops preliminary statistical tests for detecting nonlinearities in the deterministic part of SISO systems with noise. The most referenced method is unreliable for common noise processes as e.g.\\ colored. Therefore two new methods based on superposition and sinus input...... are developed. They are much more robust, especially the sinus method which is reliable also for colored, heavy tailed or skew distributed noise....

  2. Children’s Foreign Language Anxiety Scale: Preliminary Tests of Reliability and Validity

    OpenAIRE

    Aydın, Selami; Harputlu, Leyla; Güzel, Serhat; Uştuk, Özgehan; Savran Çelik, Şeyda; Genç, Deniz

    2016-01-01

    Foreign language anxiety (FLA), which constitutes a serious problem in the foreign language learning process, has been mainly seen as a research issue regarding adult language learners, while it has been overlooked in children. This is because there is a lack of appropriate tools to measure FLA among children, whereas there are many studies on the scales that aim to measure anxiety levels among adult learners. Thus, the current study aims to conduct the preliminary tests of reliability and va...

  3. The Hug-up Test: A New, Sensitive Diagnostic Test for Supraspinatus Tears

    Institute of Scientific and Technical Information of China (English)

    Yu-Lei Liu; Ying-Fang Ao; Hui Yan; Guo-Qing Cui

    2016-01-01

    Background:The supraspinatus tendon is the most commonly affected tendon in rotator cufftears.Early detection ofa supraspinatus tear using an accurate physical examination is,therefore,important.However,the currently used physical tests for detecting supraspinatus tears are poor diagnostic indicators and involve a wide range of sensitivity and specificity values.Therefore,the aim of this study was to establish a new physical test for the diagnosis of supraspinatus tears and evaluate its accuracy in comparison with conventional tests.Methods:Between November 2012 and January 2014,200 consecutive patients undergoing shoulder arthroscopy were prospectively evaluated preoperatively.The hug-up test,empty can (EC) test,full can (FC) test,Neer impingement sign,and Hawkins-Kennedy impingement sign were used and compared statistically for their accuracy in terms of supraspinatus tears,with arthroscopic findings as the gold standard.Muscle strength was precisely quantified using an electronic digital tensiometer.Results:The prevalence of supraspinatus tears was 76.5%.The hug-up test demonstrated the highest sensitivity (94.1%),with a low negative likelihood ratio (NLR,0.08) and comparable specificity (76.6%) compared with the other four tests.The area under the receiver operating characteristic curve for the hug-up test was 0.854,with no statistical difference compared with the EC test (z =1.43 8,P =0.075) or the FC test (z =1.498,P =0.067).The hug-up test showed no statistical difference in terms of detecting different tear patterns according to the position (x2 =0.578,P =0.898) and size (Fisher's exact test,P > 0.999) compared with the arthroscopic examination.The interobserver reproducibility of the hug-up test was high,with a kappa coefficient of 0.823.Conclusions:The hug-up test can accurately detect supraspinatus tears with a high sensitivity,comparable specificity,and low NLR compared with the conventional clinical tests and could,therefore,improve the

  4. The Hug-up Test: A New, Sensitive Diagnostic Test for Supraspinatus Tears

    Directory of Open Access Journals (Sweden)

    Yu-Lei Liu

    2016-01-01

    Full Text Available Background: The supraspinatus tendon is the most commonly affected tendon in rotator cuff tears. Early detection of a supraspinatus tear using an accurate physical examination is, therefore, important. However, the currently used physical tests for detecting supraspinatus tears are poor diagnostic indicators and involve a wide range of sensitivity and specificity values. Therefore, the aim of this study was to establish a new physical test for the diagnosis of supraspinatus tears and evaluate its accuracy in comparison with conventional tests. Methods: Between November 2012 and January 2014, 200 consecutive patients undergoing shoulder arthroscopy were prospectively evaluated preoperatively. The hug-up test, empty can (EC test, full can (FC test, Neer impingement sign, and Hawkins-Kennedy impingement sign were used and compared statistically for their accuracy in terms of supraspinatus tears, with arthroscopic findings as the gold standard. Muscle strength was precisely quantified using an electronic digital tensiometer. Results: The prevalence of supraspinatus tears was 76.5%. The hug-up test demonstrated the highest sensitivity (94.1%, with a low negative likelihood ratio (NLR, 0.08 and comparable specificity (76.6% compared with the other four tests. The area under the receiver operating characteristic curve for the hug-up test was 0.854, with no statistical difference compared with the EC test (z = 1.438, P = 0.075 or the FC test (z = 1.498, P = 0.067. The hug-up test showed no statistical difference in terms of detecting different tear patterns according to the position (χ2 = 0.578, P = 0.898 and size (Fisher′s exact test, P > 0.999 compared with the arthroscopic examination. The interobserver reproducibility of the hug-up test was high, with a kappa coefficient of 0.823. Conclusions: The hug-up test can accurately detect supraspinatus tears with a high sensitivity, comparable specificity, and low NLR compared with the conventional

  5. High Speed Pressure Sensitive Paint for Dynamic Testing

    Science.gov (United States)

    Pena, Carolina; Chism, Kyle; Hubner, Paul

    2016-11-01

    Pressure sensitive paint (PSP) allows engineers to obtain accurate, high-spatial-resolution measurements of pressure fields over a structure. The pressure is directly related to the luminescence emitted by the paint due to oxygen quenching. Fast PSP has a higher surface area due to its porosity compared to conventional PSP, which enables faster diffusion and measurements to be acquired three orders of magnitude faster than with conventional PSP. A fast time response is needed when testing vibrating structures due to fluid-structure interaction. The goal of this summer project was to set-up, test and analyze the pressure field of an impinging air jet on a vibrating cantilever beam using Fast PSP. Software routines were developed for the processing of the emission images, videos of a static beam coated with Fast PSP were acquired with the air jet on and off, and the intensities of these two cases were ratioed and calibrated to pressure. Going forward, unsteady pressures on a vibrating beam will be measured and presented. Eventually, the long-term goal is to integrate luminescent pressure and strain measurement techniques, simultaneously using Fast PSP and a luminescent photoelastic coating on vibrating structures. Funding from NSF REU site Grant EEC 1358991 is greatly appreciated.

  6. Local defect resonance for sensitive non-destructive testing

    Science.gov (United States)

    Adebahr, W.; Solodov, I.; Rahammer, M.; Gulnizkij, N.; Kreutzbruck, M.

    2016-02-01

    Ultrasonic wave-defect interaction is a background of ultrasound activated techniques for imaging and non-destructive testing (NDT) of materials and industrial components. The interaction, primarily, results in acoustic response of a defect which provides attenuation and scattering of ultrasound used as an indicator of defects in conventional ultrasonic NDT. The derivative ultrasonic-induced effects include e.g. nonlinear, thermal, acousto-optic, etc. responses also applied for NDT and defect imaging. These secondary effects are normally relatively inefficient so that the corresponding NDT techniques require an elevated acoustic power and stand out from conventional ultrasonic NDT counterparts for their specific instrumentation particularly adapted to high-power ultrasonic. In this paper, a consistent way to enhance ultrasonic, optical and thermal defect responses and thus to reduce an ultrasonic power required is suggested by using selective ultrasonic activation of defects based on the concept of local defect resonance (LDR). A strong increase in vibration amplitude at LDR enables to reliably detect and visualize the defect as soon as the driving ultrasonic frequency is matched to the LDR frequency. This also provides a high frequency selectivity of the LDR-based imaging, i.e. an opportunity of detecting a certain defect among a multitude of other defects in material. Some examples are shown how to use LDR in non-destructive testing techniques, like vibrometry, ultrasonic thermography and shearography in order to enhance the sensitivity of defect visualization.

  7. Sensitivity study on hydraulic well testing inversion using simulated annealing

    Energy Technology Data Exchange (ETDEWEB)

    Nakao, Shinsuke; Najita, J.; Karasaki, Kenzi

    1997-11-01

    For environmental remediation, management of nuclear waste disposal, or geothermal reservoir engineering, it is very important to evaluate the permeabilities, spacing, and sizes of the subsurface fractures which control ground water flow. Cluster variable aperture (CVA) simulated annealing has been used as an inversion technique to construct fluid flow models of fractured formations based on transient pressure data from hydraulic tests. A two-dimensional fracture network system is represented as a filled regular lattice of fracture elements. The algorithm iteratively changes an aperture of cluster of fracture elements, which are chosen randomly from a list of discrete apertures, to improve the match to observed pressure transients. The size of the clusters is held constant throughout the iterations. Sensitivity studies using simple fracture models with eight wells show that, in general, it is necessary to conduct interference tests using at least three different wells as pumping well in order to reconstruct the fracture network with a transmissivity contrast of one order of magnitude, particularly when the cluster size is not known a priori. Because hydraulic inversion is inherently non-unique, it is important to utilize additional information. The authors investigated the relationship between the scale of heterogeneity and the optimum cluster size (and its shape) to enhance the reliability and convergence of the inversion. It appears that the cluster size corresponding to about 20--40 % of the practical range of the spatial correlation is optimal. Inversion results of the Raymond test site data are also presented and the practical range of spatial correlation is evaluated to be about 5--10 m from the optimal cluster size in the inversion.

  8. Beam Dynamics for the Preliminary Phase of the New CLIC Test Facility (CTF3)

    CERN Document Server

    Corsini, R; Rinolfi, Louis; Risselada, Thys; Royer, P; Tecker, F A

    2001-01-01

    In the framework of the CLIC (Compact Linear Collider) RF power source studies, the scheme of electron pulse compression and bunch frequency mulitiplication, using injection by RF deflectors into an isochronous ring, will be tested, at low charge, during the preliminary phase of the new CLIC Test Facility (CTF3) at CERN. In this paper, we describe the beam dynamics studies made in order to assess the feasibility of the bunch combination experiment, as well as the related beam measurements performed on the LEP Pre-Injector complex (LPI) before its transformation into CTF3

  9. Blade system design studies volume II : preliminary blade designs and recommended test matrix.

    Energy Technology Data Exchange (ETDEWEB)

    Griffin, Dayton A. (Global Energy Concepts, LLC, Kirkland, WA)

    2004-06-01

    As part of the U.S. Department of Energy's Wind Partnerships for Advanced Component Technologies (WindPACT) program, Global Energy Concepts, LLC is performing a Blade System Design Study (BSDS) concerning innovations in materials, processes and structural configurations for application to wind turbine blades in the multi-megawatt range. The BSDS Volume I project report addresses issues and constraints identified to scaling conventional blade designs to the megawatt size range, and evaluated candidate materials, manufacturing and design innovations for overcoming and improving large blade economics. The current report (Volume II), presents additional discussion of materials and manufacturing issues for large blades, including a summary of current trends in commercial blade manufacturing. Specifications are then developed to guide the preliminary design of MW-scale blades. Using preliminary design calculations for a 3.0 MW blade, parametric analyses are performed to quantify the potential benefits in stiffness and decreased gravity loading by replacement of a baseline fiberglass spar with carbon-fiberglass hybrid material. Complete preliminary designs are then presented for 3.0 MW and 5.0 MW blades that incorporate fiberglass-to-carbon transitions at mid-span. Based on analysis of these designs, technical issues are identified and discussed. Finally, recommendations are made for composites testing under Part I1 of the BSDS, and the initial planned test matrix for that program is presented.

  10. Sensitivity of permanent meadows areas. Preliminary report; Sensibilite des zones de prairies permanentes. Rapport preliminaire

    Energy Technology Data Exchange (ETDEWEB)

    Pourcelot, L

    2006-07-01

    The objective of this work proposed in the framework of the S.E.N.S.I.B. project on the permanent meadows areas is to compare the sensitivity of these surfaces and cheese maker sector which are associated with them, and to identify the processes which determine this sensitivity. The realization of this objective will lean on certain data of activities acquired recently by the I.R.S.N. (compartments: soils, herb, milk and cheese), as well as on new measures, on three sites: Saint-Laurent-de-Geris ( West), Beaune-Le-Froid ( center), and Massif of Jura (East). Two scales of transfers observation and sensitivity are retained. In a first time, the sensitivity of meadows areas will studied at the regional scale, from data acquired in the Massif du Jura ( between 300 and 1200 metres up). In a second time, a study will allow to compare the sensitivity of three areas retained (West, Center, East) at the national scale. The expertise will be focused on the factors of sensitivity of the transfer soil-herb and the factors of sensitivity bound to the cheese makers sectors. The data of the already available zones of study create strong variabilities of the rates of {sup 137}Cs transfer in the interfaces soil / herb and herb / milk, letting suppose that the nature of soils, the quantity and the quality of food ingested by the cattle constitutes dominating factors of sensitivity. Besides, the size of the basin of milk collection, extremely variable from a site of study in the other one, has to influence the contamination of cheeses and as such, it establishes an important factor of sensitivity of the cheese makers sector. (N.C.)

  11. Characteristics, finite element analysis, test description, and preliminary test results of the STM4-120 kinematic Stirling engine

    Science.gov (United States)

    Linker, K. L.; Rawlinson, K. S.; Smith, G.

    1991-10-01

    The Department of Energy's Solar Thermal Program has, as one of its program elements, the development and evaluation of conversion device technologies applicable to dish-electric systems. The primary research and development combines a conversion device (heat engine), solar receiver, and generator mounted at the focus of a parabolic dish concentrator. The Stirling-cycle heat engine was identified as the conversion device for dish-electric with the most potential for meeting the program's goals for efficiency, reliability, and installed cost. To advance the technology toward commercialization, Sandia National Laboratories has acquired a Stirling Thermal Motors, Inc. kinematic Stirling engine, STM4-120, for evaluation. The engine is being bench-tested at Sandia's Engine Test Facility and will be combined later with a solar receiver for on-sun evaluation. This report presents the engine characteristics, finite element analyses of critical engine components, test system layout, instrumentation, and preliminary performance results from the bench test.

  12. Development and Preliminary Tests of an Open-Path Airborne Diode Laser Absorption Instrument for Carbon Dioxide

    Science.gov (United States)

    Diskin, Glenn S.; DiGangi, Joshua P.; Yang, Melissa; Slate, Thomas A.; Rana, Mario

    2015-01-01

    Carbon dioxide (CO2) is well known for its importance as an atmospheric greenhouse gas, with many sources and sinks around the globe. Understanding the fluxes of carbon into and out of the atmosphere is a complex and daunting challenge. One tool applied by scientists to measure the vertical flux of CO2 near the surface uses the eddy covariance technique, most often from towers but also from aircraft flying specific patterns over the study area. In this technique, variations of constituents of interest are correlated with fluctuations in the local vertical wind velocity. Measurement requirements are stringent, particularly with regard to precision, sensitivity to small changes, and temporal sampling rate. In addition, many aircraft have limited payload capability, so instrument size, weight, and power consumption are also important considerations. We report on the development and preliminary application of an airborne sensor for the measurement of atmospheric CO2. The instrument, modeled on the successful DLH (Diode Laser Hygrometer) series of instruments, has been tested in the laboratory and on the NASA DC-8 aircraft. Performance parameters such as accuracy, precision, sensitivity, specificity, and temporal response are discussed in the context of typical atmospheric variability and suitability for flux measurement applications. On-aircraft, in-flight data have been obtained and are discussed as well. Performance of the instrument has been promising, and continued flight testing is planned during 2016.

  13. Assessment of wavefront aberration and contrast sensitivity test as evaluation of postoperative visual quality

    OpenAIRE

    Min Gong; Yi Liu; Bi Yang

    2013-01-01

    Effective methods of evaluating postoperative visual quality include wavefront aberration and contrast sensitivity test. This article provides a review of the concepts and clinical applications as well as their interactions of wavefront aberration and contrast sensitivity test.This article also provides a comprehensive assessment of the effectiveness of wavefront aberration and contrast sensitivity test as evaluation tools of postoperative visual quality.

  14. Preliminary evidence about the effects of meditation on interoceptive sensitivity and social cognition

    OpenAIRE

    Melloni, Margherita; Sedeño, Lucas; Couto, Juan Blas Marcos; Reynoso, Martín; Gelormini Lezama, Carlos; Favaloro, Roberto; Canales Johnson, Andres; Sigman, Mariano; Manes, Facundo Francisco; Ibañez, Agustín

    2015-01-01

    Background: Interoception refers to the conscious perception of body signals. Mindfulness is a meditation practice that encourages individuals to focus on their internal experiences such as bodily sensations, thoughts, and emotions. In this study, we selected a behavioral measure of interoceptive sensitivity (heartbeat detection task, HBD) to compare the effect of meditation practice on interoceptive sensitivity among long term practitioners (LTP), short term meditators (STM, subjects that co...

  15. Pressure-Sensitive Paints Advance Rotorcraft Design Testing

    Science.gov (United States)

    2013-01-01

    The rotors of certain helicopters can spin at speeds as high as 500 revolutions per minute. As the blades slice through the air, they flex, moving into the wind and back out, experiencing pressure changes on the order of thousands of times a second and even higher. All of this makes acquiring a true understanding of rotorcraft aerodynamics a difficult task. A traditional means of acquiring aerodynamic data is to conduct wind tunnel tests using a vehicle model outfitted with pressure taps and other sensors. These sensors add significant costs to wind tunnel testing while only providing measurements at discrete locations on the model's surface. In addition, standard sensor solutions do not work for pulling data from a rotor in motion. "Typical static pressure instrumentation can't handle that," explains Neal Watkins, electronics engineer in Langley Research Center s Advanced Sensing and Optical Measurement Branch. "There are dynamic pressure taps, but your costs go up by a factor of five to ten if you use those. In addition, recovery of the pressure tap readings is accomplished through slip rings, which allow only a limited amount of sensors and can require significant maintenance throughout a typical rotor test." One alternative to sensor-based wind tunnel testing is pressure sensitive paint (PSP). A coating of a specialized paint containing luminescent material is applied to the model. When exposed to an LED or laser light source, the material glows. The glowing material tends to be reactive to oxygen, explains Watkins, which causes the glow to diminish. The more oxygen that is present (or the more air present, since oxygen exists in a fixed proportion in air), the less the painted surface glows. Imaged with a camera, the areas experiencing greater air pressure show up darker than areas of less pressure. "The paint allows for a global pressure map as opposed to specific points," says Watkins. With PSP, each pixel recorded by the camera becomes an optical pressure

  16. Preliminary Test of Friction disk type turbine for S-CO{sub 2} cycle application

    Energy Technology Data Exchange (ETDEWEB)

    Baik, Seungjoon; Kim, Hyeon Tae; Lee, Jeong Ik [KAIST, Daejeon (Korea, Republic of)

    2016-05-15

    Due to the relatively mild sodium-CO{sub 2} interaction, the S-CO{sub 2} Brayton cycle can reduce the accident consequence compared to the steam Rankine cycle. Also the S-CO{sub 2} power conversion cycle can achieve high efficiency for SFR core thermal condition. Moreover, the S-CO{sub 2} power cycle can reduce the total cycle footprint due to high density of the working fluid. However, the high pressure operating condition and low viscosity of the fluid cause difficulties in designing appropriate seals and multi-stage turbo machineries. To solve the problem for designing turbo machineries in a creative way, KAIST research team tested a friction disk type turbine concept for the S-CO{sub 2} cycle application. In this paper, the investigation of the Tesla turbine and preliminary test results with compressed air are covered. The KAIST research team investigated a friction disk type turbine, named as Tesla turbine, for the S-CO{sub 2} power cycle applications. Due to the robust design of the fiction disk type, the Tesla turbine technology can be utilized not only for S-CO{sub 2} turbo machinery but also for the multi-phase or sludge flow turbo machinery. The preliminary test of lab-scale Tesla turbine with compressed air was conducted. The high pressure vessel was manufactured for the S-CO{sub 2} operating condition. The test will be concentrated on the turbine efficiency measurement under various conditions and development of the design methodology.

  17. Preliminary Design of Large Scale Sodium Thermal-Hydraulic Test Facility

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Tae Ho; Kim, Tae Joon; Eoh, Jae Hyuk; Lee, Hyeong Yeon; Lee, Jae Han; Jeong, Ji Young; Park, Su Ki; Han, Ji Woong; Yoo, Yong Hwan; Lee, Yong Bum [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2009-10-15

    A large scale sodium thermal-hydraulic test facility is being designed for verification of the advanced design concept of the passive decay heat removal circuit (PDRC) in a medium- or large-sized pool-type SFR. In the test, its cooling capability during the long- and short-term periods after the reactor trip will be evaluated, and also the produced experimental data will be utilized for the assessment and verification of the safety and performance analysis codes. Starting with the preliminary design of the test facility this year using KALIMER-600 as a reference reactor, the basic and the detailed designs will be made through 2011-2012 based on the demonstration reactor which is intended to be constructed by 2028 according to a long-term national SFR development plan. The installation is scheduled to be completed by the end of 2013, and the main experiments will commence from 2015 after the startup test in 2014. This paper briefly introduces the preliminary design features which were produced as a first step to assess the appropriateness of the facility design methodology.

  18. A Preliminary Analysis of Reactor Performance Test (LOEP) for a Research Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyeonil; Park, Su-Ki [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-10-15

    The final phase of commissioning is reactor performance test, which is to prove the integrated performance and safety of the research reactor at full power with fuel loaded such as neutron power calibration, Control Absorber Rod/Second Shutdown Rod drop time, InC function test, Criticality, Rod worth, Core heat removal with natural mechanism, and so forth. The last test will be safety-related one to assure the result of the safety analysis of the research reactor is marginal enough to be sure about the nuclear safety by showing the reactor satisfies the acceptance criteria of the safety functions such as for reactivity control, maintenance of auxiliaries, reactor pool water inventory control, core heat removal, and confinement isolation. After all, the fuel integrity will be ensured by verifying there is no meaningful change in the radiation levels. To confirm the performance of safety equipment, loss of normal electric power (LOEP), possibly categorized as Anticipated Operational Occurrence (AOO), is selected as a key experiment to figure out how safe the research reactor is before turning over the research reactor to the owner. This paper presents a preliminary analysis of the reactor performance test (LOEP) for a research reactor. The results showed how different the transient between conservative estimate and best estimate will look. Preliminary analyses have shown all probable thermal-hydraulic transient behavior of importance as to opening of flap valve, minimum critical heat flux ratio, the change of flow direction, and important values of thermal-hydraulic parameters.

  19. Narrative foreclosure in later life: Preliminary considerations for a new sensitizing concept

    NARCIS (Netherlands)

    Bohlmeijer, Ernst Thomas; Westerhof, Gerben Johan; Randall, W.; Tromp, T.; Kenyon, G.

    2011-01-01

    The objective of the paper is to explore narrative foreclosure as a sensitizing concept for studying the ways in which narrative identity development falters in later life. Two main characters in famous movies are contrasted to provide a better understanding of narrative foreclosure. The concept is

  20. Narrative foreclosure in later life: preliminary considerations for a new sensitizing concept

    NARCIS (Netherlands)

    Bohlmeijer, E.T.; Westerhof, G.J.; Randall, W.; Tromp, T.; Kenyon, G.

    2011-01-01

    The objective of the paper is to explore narrative foreclosure as a sensitizing concept for studying the ways in which narrative identity development falters in later life. Two main characters in famous movies are contrasted to provide a better understanding of narrative foreclosure. The concept is

  1. Preliminary test of the prototype modular cryostat for a 10 MW offshore superconducting wind turbine

    Science.gov (United States)

    Sun, Jiuce; Ramalingam, R.; Sanz, Santiago; Neumann, Holger

    2017-02-01

    The SUPerconducting Reliable lightweight And more POWERful offshore wind turbine (SUPRAPOWER), an EU FP7 funded research project, are under development for an innovative superconducting 10 MW class offshore wind turbine. Due to the requirements of handling, maintenance, reliability of long term and offshore operation, the cryostats are divided in two major parts: the modular cryostat able to accommodate a single coil and a thermal collector that links all the modules. The prototype modular cryostat was designed, manufactured and assembled in Karlsruhe Institute of Technology (KIT). The paper reports preliminary test results of proto-type modular cryostat with a two-stage Gifford-McMahon (GM) cryocooler.

  2. Nonlinear Analysis and Preliminary Testing Results of a Hybrid Wing Body Center Section Test Article

    Science.gov (United States)

    Przekop, Adam; Jegley, Dawn C.; Rouse, Marshall; Lovejoy, Andrew E.; Wu, Hsi-Yung T.

    2015-01-01

    A large test article was recently designed, analyzed, fabricated, and successfully tested up to the representative design ultimate loads to demonstrate that stiffened composite panels with through-the-thickness reinforcement are a viable option for the next generation large transport category aircraft, including non-conventional configurations such as the hybrid wing body. This paper focuses on finite element analysis and test data correlation of the hybrid wing body center section test article under mechanical, pressure and combined load conditions. Good agreement between predictive nonlinear finite element analysis and test data is found. Results indicate that a geometrically nonlinear analysis is needed to accurately capture the behavior of the non-circular pressurized and highly-stressed structure when the design approach permits local buckling.

  3. Potential of preliminary test methods to predict biodegradation performance of petroleum hydrocarbons in soil.

    Science.gov (United States)

    Aichberger, H; Hasinger, Marion; Braun, Rudolf; Loibner, Andreas P

    2005-03-01

    Preliminary tests at different scales such as degradation experiments (laboratory) in shaking flasks, soil columns and lysimeters as well as in situ respiration tests (field) were performed with soil from two hydrocarbon contaminated sites. Tests have been evaluated in terms of their potential to provide information on feasibility, degradation rates and residual concentration of bioremediation in the vadose zone. Sample size, costs and duration increased with experimental scale in the order shaking flasks - soil columns - lysimeter - in situ respiration tests, only time demand of respiration tests was relatively low. First-order rate constants observed in degradation experiments exhibited significant differences between both, different experimental sizes and different soils. Rates were in line with type and history of contamination at the sites, but somewhat overestimated field rates particularly in small scale experiments. All laboratory experiments allowed an estimation of residual concentrations after remediation. In situ respiration tests were found to be an appropriate pre-testing and monitoring tool for bioventing although residual concentrations cannot be predicted from in situ respiration tests. Moreover, this method does not account for potential limitations that might hamper biodegradation in the longer term but only reflects the actual degradation potential when the test is performed.

  4. Turkish children's Bender-Gestalt Test performance: a pilot study and preliminary norms.

    Science.gov (United States)

    Ozer, Serap

    2007-12-01

    The present study was undertaken to provide preliminary data for norms on the Bender-Gestalt Test for 253 children ages 5 yr., 5 mo. to 11 yr., 10 mo. in Turkey. The Koppitz Developmental Scoring System gave mean error scores of 4.2 (SD = 3.3) for girls and 3.6 (SD = 3.0) for boys. The mean error scores obtained by all age groups are presented and compared with other cross-cultural data. These scores decreased across age groups, supporting Bender's maturational hypothesis of the test. The present sample performed at a higher developmental level than the Koppitz normative sample for the 5- and 6-year age groups, while means for other age groups were similar to the original U.S. norms. That this pattern is supported in other cross-cultural studies is discussed as well as the importance of developing local norms for visual spatial tests.

  5. Preliminary optical design of an Active Optics test bench for space applications.

    Science.gov (United States)

    Calcines, A.; Bitenc, U.; Rolt, S.; Reeves, S.; Doelman, N.; Human, J.; Morris, T.; Myers, R.; Talbot, G.

    2017-03-01

    This communication presents a preliminary optical design for a test bench conceived within the European Space Agency's TRP project (Active Optics Correction Chain (AOCC) for large monolithic mirrors) with the goal of designing and developing an Active Optics system able to correct in space on telescopes apertures larger than 3 meters. The test bench design uses two deformable mirrors of 37.5 mm and 116 mm, the smallest mirror to generate aberrations and the largest one to correct them. The system is configured as a multi-functional test bench capable of verifying the performance of a Shack-Hartmann wavefront sensor as well as of a Phase Diversity based wavefront sensor. A third optical path leads to a high-order Shack-Hartmann wavefront sensor to monitor the entire system performance.

  6. The NASA Juncture Flow Experiment: Goals, Progress, and Preliminary Testing (Invited)

    Science.gov (United States)

    Rumsey, Christopher L.; Neuhart, Danny H.; Kegerise, Michael A.

    2016-01-01

    NASA has been working toward designing and conducting a juncture flow experiment on a wing-body aircraft configuration. The experiment is planned to provide validation-quality data for CFD that focuses on the onset and progression of a separation bubble near the wing-body juncture trailing edge region. This paper describes the goals and purpose of the experiment. Although currently considered unreliable, preliminary CFD analyses of several different configurations are shown. These configurations have been subsequently tested in a series of "risk-reduction" wind tunnel tests, in order to help down-select to a final configuration that will attain the desired flow behavior. The risk-reduction testing at the higher Reynolds number has not yet been completed (at the time of this writing), but some results from one of the low-Reynolds-number experiments are shown.

  7. Contact sensitivity in mice evaluated by means of ear swelling and a radiometric test

    Energy Technology Data Exchange (ETDEWEB)

    Baeck, O.; Larsen, A.

    1982-04-01

    Contact sensitivity to picryl chloride was investigated by means of the ear swelling test and a radiometric test in order to establish optimal experimental conditions for these assays. Contact sensitivity was demonstrated as soon as 2 days after sensitization, with a maximum reaction 3-4 days after sensitization, when a 48 hr test reaction was registered. The test reaction was followed for 72 hr and maximum was arrived at after 24 hr and 48 hr for the ear swelling test and the radiometric test, respectively. Optimal sensitization was reached with a 7% solution of picryl chloride and a maximum test reaction was found with 0.75-1.0% picryl chloride. It is concluded that both assays measure contact sensitivity in quantitative terms and a future replacement of the guinea pig maximization test is discussed.

  8. A Sensitivity Analysis of a Pipe Break Accident in a Preliminary Specific Design of the PGSFR

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kwi Lim; Jeong, Jae Ho; Ha, Kwi Seok [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-05-15

    The PGSFR (Prototype Gen-IV Sodium-cooled Fast Reactor) is a pool type sodium cooled fast reactor with a thermal power of 392.1 MW which has been developed in accord with an enhanced safety, an efficient utilization of uranium resources and a reduction of a high level waste volume in the Korea Atomic Energy Research Institute (KAERI) since 2012 under a National Nuclear R and D Program. The PGSFR has an inherent safety characteristic owing to the design to have a negative power reactivity coefficient during all operation modes and it has a passive safety characteristic due to the design of a passive decay heat removal circuit. In order to assess the inherent safety features of the PGSFR, a safety analysis was performed for a pipe break accident with MARS-LMR. And, the sensitivity studies were also performed to find the most conservative condition. As a result, the PGSFR was appropriately tripped by a high power to PHTS flow ratio using the method of extracting the PHTS flow rate from the pressure drop. The air flow rate was the most sensitive variable in the sensitivity analysis. Therefore, it is important to know the accurate uncertainty of the air flow rate in the AHX.

  9. Preliminary Design Report of Fluid System of PDRC Performance Test Facility

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Tae-Ho; Eoh, Jae-Hyuk; Seong, Seung-Hwan; Han, Ji-Woong; Choi, Byoung-Hae; Kim, Seong-O

    2008-10-15

    PDRC (Passive Decay Heat Removal Circuit) is a safety grade passive residual heat removal system of KALIMER-600. In order to assess the long- and short-term cooling capabilities of PDRC and produce the experimental data for the verification of the performance and safety analysis codes, PDRC performance test was planned for. In this study, the overall design requirements and the preliminary design data for the fluid system of test facility are presented. The fluid system of the facility is composed of the primary heat transport system, the PDRC, the IHX air cooling system and the sodium supply/purification system. The preliminarily designed facility is scaled-down to 1/4 for length, 1/400 for volume from the primary heat transport system and the PDRC of KALIMER-600 based on a reliable scaling method. It can simulate the cooling of primary heat transport system for the full temperature condition in case of the reactor and pump trips. The produced preliminary design data will be used in the future as the basic information for a detailed design, an establishment of experimental requirement and an assessment of the appropriateness of facility design.

  10. Design, validation, and absolute sensitivity of a novel test for the molecular detection of avian pneumovirus.

    Science.gov (United States)

    Cecchinato, Mattia; Catelli, Elena; Savage, Carol E; Jones, Richard C; Naylor, Clive J

    2004-11-01

    This study describes attempts to increase and measure sensitivity of molecular tests to detect avian pneumovirus (APV). Polymerase chain reaction (PCR) diagnostic tests were designed for the detection of nucleic acid from an A-type APV genome. The objective was selection of PCR oligonucleotide combinations, which would provide the greatest test sensitivity and thereby enable optimal detection when used for later testing of field materials. Relative and absolute test sensitivities could be determined because of laboratory access to known quantities of purified full-length DNA copies of APV genome derived from the same A-type virus. Four new nested PCR tests were designed in the fusion (F) protein (2 tests), small hydrophobic (SH) protein (1 test), and nucleocapsid (N) protein (1 test) genes and compared with an established test in the attachment (G) protein gene. Known amounts of full-length APV genome were serially diluted 10-fold, and these dilutions were used as templates for the different tests. Sensitivities were found to differ between the tests, the most sensitive being the established G test, which proved able to detect 6,000 copies of the G gene. The G test contained predominantly pyrimidine residues at its 3' termini, and because of this, oligonucleotides for the most sensitive F test were modified to incorporate the same residue types at their 3' termini. This was found to increase sensitivity, so that after full 3' pyrimidine substitutions, the F test became able to detect 600 copies of the F gene.

  11. Preliminary analysis of grain-size populations with environmentally sensitive terrigenous components in marginal sea setting

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Terrigenous components were separated from the bulk sediment of Core A7 from the Okinawa Trough and Core A37 from the Ryukru Trench and grain-size distributions of these sub-samples were analyzed. Based upon an analysis of the grain-size data of the two sedimentary sequences, grain-size populations are identified to be sensitive to sedimentary environmental changes. The modal values and size ranges of the two main grain-size populations in Core A7 are evidently different from those of Core A37, indicating the spatial variability of sediment sources and transport processes between the two places. The downcore variations in the content of the environmentally sensitive grain-size populations reveal that during the accumulation of sedimentary material the environment remained relatively stable at the site where Core A7 was collected, except for the apparent events for the formation of two turbidite layers and a volcanic ash layer. However, the sedimentary sequence of Core A37 shows six sedimentary cycles, indicating a highly variable sedimentary environment at this location.

  12. Sensitivity and specificity of neuropsychological tests for dementia ...

    African Journals Online (AJOL)

    specificity of a battery of neuropsychological tests in a sample of .... psychological scores and 95% confidence intervals .... psychological tests in elderly participants ..... verbal fluency tasks in the detection of dementia of the Alzheimer type.

  13. 78 FR 68076 - Request for Information on Alternative Skin Sensitization Test Methods and Testing Strategies and...

    Science.gov (United States)

    2013-11-13

    ... workers and consumers exposed to skin-sensitizing chemicals and products. Pesticides and other marketed... relationship (SAR) models to predict skin sensitization. NICEATM collaboration with industry scientists to... sensitization. Participating in validation management groups sponsored by ICATM partner organizations to...

  14. Concrete spalling sensitivity versus microstructure: Preliminary results on the effect of polypropylene fibers

    Directory of Open Access Journals (Sweden)

    Rossino Chiara

    2013-09-01

    Full Text Available The phisyco-mechanical processes triggering concrete explosive spalling are related to the heat-induced micro- and meso-structural changes. To have new information on concrete properties at the microstructural level, as well as on how concrete spalling sensitivity is affected by polypropylene and steel fibers, and by aggregate type, ordinary and high-performance concretes are investigated in this research project, after being heated to different temperatures. The focus is on the relationship among porosity, vapor permeability, pore pressure and microcracking inside the cementitious matrix. Polypropylene fibers are shown to increase the total porosity, to favor microcracking and to reduce significantly pore pressure, to the advantage of concrete resistance to explosive spalling, whose risk is markedly reduced – or even zeroed.

  15. Preliminary Structural Sensitivity Study of Hypersonic Inflatable Aerodynamic Decelerator Using Probabilistic Methods

    Science.gov (United States)

    Lyle, Karen H.

    2014-01-01

    Acceptance of new spacecraft structural architectures and concepts requires validated design methods to minimize the expense involved with technology validation via flighttesting. This paper explores the implementation of probabilistic methods in the sensitivity analysis of the structural response of a Hypersonic Inflatable Aerodynamic Decelerator (HIAD). HIAD architectures are attractive for spacecraft deceleration because they are lightweight, store compactly, and utilize the atmosphere to decelerate a spacecraft during re-entry. However, designers are hesitant to include these inflatable approaches for large payloads or spacecraft because of the lack of flight validation. In the example presented here, the structural parameters of an existing HIAD model have been varied to illustrate the design approach utilizing uncertainty-based methods. Surrogate models have been used to reduce computational expense several orders of magnitude. The suitability of the design is based on assessing variation in the resulting cone angle. The acceptable cone angle variation would rely on the aerodynamic requirements.

  16. PRELIMINARY RESULTS REGARDING THE SENSITIVITY OF TULIPA GESNERIANA L. MERISTEMATIC ROOT CELLS TO FUNGICIDE FOLPAN

    Directory of Open Access Journals (Sweden)

    Nicoleta Anca Şuţan

    2015-07-01

    Full Text Available The genotoxicity of the pesticide Folpan was evaluated in meristematic root cells of Tulipa gesneriana cv. ‘Leen van der Mark’. The statistical analyses of the results showed that the pesticide studied has a concentration-dependent toxicity and induces chromosomal aberrations. The lowest mitotic index (2,69% was related with the highest tested concentration of Folpan (900 ppm. Various types of chromosomal and mitotic abnormalities such as binucleated cells, laggards, and disturbed ana-telophase with multiple chromosomal bridges revealed the clastogenic potential of pesticide tested.

  17. Preliminary experimental results from the ICARUS test facility at INFN-LNL

    Energy Technology Data Exchange (ETDEWEB)

    Varanini, F. [Dept. of Physics and INFN, University of Padova, via Marzolo 8, 35100 Padova (Italy)

    2009-12-15

    A liquid Argon TPC with a sensitive volume of 27 l has been operated with cosmic rays in the INFN-LNL laboratories. This detector is used to test possible DAQ and trigger solutions for ICARUS and future liquid Argon TPCs.

  18. Extended testing of a general contextual classifier using the massively parallel processor - Preliminary results and test plans. [for thematic mapping

    Science.gov (United States)

    Tilton, J. C.

    1985-01-01

    Earlier encouraging test results of a contextual classifier that combines spatial and spectral information employing a general statistical approach are expanded. The earlier results were of limited meaning because they were produced from small (50-by-50 pixel) data sets. An implementation of the contextual classifier on NASA Goddard's Massively Parallel Processor (MPP) is presented; for the first time the MPP makes feasible the testing of the classifier on large data sets (a 12-hour test on a VAX-11/780 minicomputer now takes 5 minutes on the MPP). The MPP is a Single-Instruction, Multiple Data Stream computer, consisting of 16,384 bit serial microprocessors connected in a 128-by-128 mesh array with each element having data transfer connections with its four nearest neighbors so that the MPP is capable of billions of operations per second. Preliminary results are given (with more expected for the conference) and plans are mentioned for extended testing of the contextual classifier on Thematic Mapper data sets.

  19. Sensitivity and specificity of the nickel spot (dimethylglyoxime) test

    DEFF Research Database (Denmark)

    Thyssen, Jacob P; Skare, Lizbet; Lundgren, Lennart;

    2010-01-01

    The accuracy of the dimethylglyoxime (DMG) nickel spot test has been questioned because of false negative and positive test reactions. The EN 1811, a European standard reference method developed by the European Committee for Standardization (CEN), is fine-tuned to estimate nickel release around...... the limit value of the EU Nickel Directive from products intended to come into direct and prolonged skin contact. Because assessments according to EN 1811 are expensive to perform, time consuming, and may destruct the test item, it should be of great value to know the accuracy of the DMG screening test....

  20. Validating a dance-specific screening test for balance: preliminary results from multisite testing.

    Science.gov (United States)

    Batson, Glenna

    2010-09-01

    Few dance-specific screening tools adequately capture balance. The aim of this study was to administer and modify the Star Excursion Balance Test (oSEBT) to examine its utility as a balance screen for dancers. The oSEBT involves standing on one leg while lightly targeting with the opposite foot to the farthest distance along eight spokes of a star-shaped grid. This task simulates dance in the spatial pattern and movement quality of the gesturing limb. The oSEBT was validated for distance on athletes with history of ankle sprain. Thirty-three dancers (age 20.1 +/- 1.4 yrs) participated from two contemporary dance conservatories (UK and US), with or without a history of lower extremity injury. Dancers were verbally instructed (without physical demonstration) to execute the oSEBT and four modifications (mSEBT): timed (speed), timed with cognitive interference (answering questions aloud), and sensory disadvantaging (foam mat). Stepping strategies were tracked and performance strategies video-recorded. Unlike the oSEBT results, distances reached were not significant statistically (p = 0.05) or descriptively (i.e., shorter) for either group. Performance styles varied widely, despite sample homogeneity and instructions to control for strategy. Descriptive analysis of mSEBT showed an increased number of near-falls and decreased timing on the injured limb. Dancers appeared to employ variable strategies to keep balance during this test. Quantitative analysis is warranted to define balance strategies for further validation of SEBT modifications to determine its utility as a balance screening tool.

  1. Sensitivity and specificity of the nickel spot (dimethylglyoxime) test

    DEFF Research Database (Denmark)

    Thyssen, Jacob P; Skare, Lizbet; Lundgren, Lennart

    2010-01-01

    the limit value of the EU Nickel Directive from products intended to come into direct and prolonged skin contact. Because assessments according to EN 1811 are expensive to perform, time consuming, and may destruct the test item, it should be of great value to know the accuracy of the DMG screening test....

  2. Temperature-sensitive mutants of Pseudomonas aeruginosa: isolation and preliminary immunological evaluation.

    Science.gov (United States)

    Hooke, A M; Arroyo, P J; Oeschger, M P; Bellanti, J A

    1982-01-01

    The immunogenicity of two temperature-sensitive (ts) mutants of Pseudomonas aeruginosa immunotype 1, isolated and characterized for the development of a safe, live vaccine strain, was evaluated in a mouse protection model. One mutant, A/10/25, had a limited "coasting" property (i.e., continued replication for two divisions) at the nonpermissive temperature (36 degrees C), whereas the other mutant, E/9/9, continued replication for five generations after transfer to 36 degrees C. Groups of 3- to 5-week-old ICR mice were immunized intraperitoneally with various doses of the two ts mutants; at various times thereafter, the mice were challenged intraperitoneally with lethal doses of the parental wild type. The more extensive coaster, E/9/9, induced 100% protection at immunizing doses lower than those required for A/10/25 to induce the same protection (1 x 10(8) to 2 x 10(8) and 6 x 10(8) colony-forming units, respectively). Both ts strains induced significant protection for up to 5 weeks after immunization. The results of these studies suggest that the use of P. aeruginosa ts mutants might provide a novel approach to the prevention of P. aeruginosa colonization of patients with cystic fibrosis. PMID:6815088

  3. Preliminary study fo the interference of proteic compounds of radiopharmaceuticals in the test of lisadode amebocitos de limulus (LAL)

    CERN Document Server

    Aldana, C

    1997-01-01

    In this thesis the objective was evaluate the interference of proteic compounds of the radiopharmaceuticals in the test LAL (lisado of amebocitos de limulus) for this, macroagregates of albumina (MAA) was used with metilendifosfonato (MDP) as control that is the radiopharmaceutical more used in the nuclear medicine centers of the country. Initially preliminary test were carried out to assess if some of two radiopharmaceuticals would cause interference with LAL test, after the test was validated and finally routine tests were made. With the preliminary assays was concluded that proteic compounds did not cause interference (albumina with a concentration of 2 md/dl) with the MAA. However with the MDP cause interference with LAL test. The interference was eliminated with a dilution of 1:8 of the sample. Was concluded that the success of LAL test depends on conditions such as temperature, pH, constant incubation (no minimum variations) and that is a good test for quality control of the radiopharmaceuticals.

  4. Smart licensing and environmental flows: Modeling framework and sensitivity testing

    Science.gov (United States)

    Wilby, R. L.; Fenn, C. R.; Wood, P. J.; Timlett, R.; Lequesne, T.

    2011-12-01

    Adapting to climate change is just one among many challenges facing river managers. The response will involve balancing the long-term water demands of society with the changing needs of the environment in sustainable and cost effective ways. This paper describes a modeling framework for evaluating the sensitivity of low river flows to different configurations of abstraction licensing under both historical climate variability and expected climate change. A rainfall-runoff model is used to quantify trade-offs among environmental flow (e-flow) requirements, potential surface and groundwater abstraction volumes, and the frequency of harmful low-flow conditions. Using the River Itchen in southern England as a case study it is shown that the abstraction volume is more sensitive to uncertainty in the regional climate change projection than to the e-flow target. It is also found that "smarter" licensing arrangements (involving a mix of hands off flows and "rising block" abstraction rules) could achieve e-flow targets more frequently than conventional seasonal abstraction limits, with only modest reductions in average annual yield, even under a hotter, drier climate change scenario.

  5. Sensitivity Analysis of OECD Benchmark Tests in BISON

    Energy Technology Data Exchange (ETDEWEB)

    Swiler, Laura Painton [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gamble, Kyle [Idaho National Lab. (INL), Idaho Falls, ID (United States); Schmidt, Rodney C. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Williamson, Richard [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-09-01

    This report summarizes a NEAMS (Nuclear Energy Advanced Modeling and Simulation) project focused on sensitivity analysis of a fuels performance benchmark problem. The benchmark problem was defined by the Uncertainty Analysis in Modeling working group of the Nuclear Science Committee, part of the Nuclear Energy Agency of the Organization for Economic Cooperation and Development (OECD ). The benchmark problem involv ed steady - state behavior of a fuel pin in a Pressurized Water Reactor (PWR). The problem was created in the BISON Fuels Performance code. Dakota was used to generate and analyze 300 samples of 17 input parameters defining core boundary conditions, manuf acturing tolerances , and fuel properties. There were 24 responses of interest, including fuel centerline temperatures at a variety of locations and burnup levels, fission gas released, axial elongation of the fuel pin, etc. Pearson and Spearman correlatio n coefficients and Sobol' variance - based indices were used to perform the sensitivity analysis. This report summarizes the process and presents results from this study.

  6. Preliminary piping layout and integration of European test blanket modules subsystems in ITER CVCS area

    Energy Technology Data Exchange (ETDEWEB)

    Tarallo, Andrea, E-mail: andrea.tarallo@unina.it [CREATE, University of Naples Federico II, DII, P.le Tecchio, 80, 80125 Naples (Italy); Mozzillo, Rocco; Di Gironimo, Giuseppe [CREATE, University of Naples Federico II, DII, P.le Tecchio, 80, 80125 Naples (Italy); Aiello, Antonio; Utili, Marco [ENEA UTIS, C.R. Brasimone, Bacino del Brasimone, I-40032 Camugnano, BO (Italy); Ricapito, Italo [TBM& MD Project, Fusion for Energy, EU Commission, Carrer J. Pla, 2, Building B3, 08019 Barcelona (Spain)

    2015-04-15

    Highlights: • The use of human modeling tools for piping design in view of maintenance is discussed. • A possible preliminary layout for TBM subsystems in CVCS area has been designed with CATIA. • A DHM-based method to quickly check for maintainability of piping systems is suggested. - Abstract: This paper explores a possible integration of some ancillary systems of helium-cooled lithium lead (HCLL) and helium-cooled pebble-bed (HCPB) test blanket modules in ITER CVCS area. Computer-aided design and ergonomics simulation tools have been fundamental not only to define suitable routes for pipes, but also to quickly check for maintainability of equipment and in-line components. In particular, accessibility of equipment and systems has been investigated from the very first stages of the design using digital human models. In some cases, the digital simulations have resulted in changes in the initial space reservations.

  7. Preliminary safety evaluation (PSE) for Sodium Storage Facility at the Fast Flux Test Facility

    Energy Technology Data Exchange (ETDEWEB)

    Bowman, B.R.

    1994-09-30

    This evaluation was performed for the Sodium Storage Facility (SSF) which will be constructed at the Fast Flux Test Facility (FFTF) in the area adjacent to the South and West Dump Heat Exchanger (DHX) pits. The purpose of the facility is to allow unloading the sodium from the FFTF plant tanks and piping. The significant conclusion of this Preliminary Safety Evaluation (PSE) is that the only Safety Class 2 components are the four sodium storage tanks and their foundations. The building, because of its imminent risk to the tanks under an earthquake or high winds, will be Safety Class 3/2, which means the building has a Safety Class 3 function with the Safety Class 2 loads of seismic and wind factored into the design.

  8. The preliminary tests of the superconducting electron cyclotron resonance ion source DECRIS-SC2.

    Science.gov (United States)

    Efremov, A; Bekhterev, V; Bogomolov, S; Drobin, V; Loginov, V; Lebedev, A; Yazvitsky, N; Yakovlev, B

    2012-02-01

    A new compact version of the "liquid He-free" superconducting ECR ion source, to be used as an injector of highly charged heavy ions for the MC-400 cyclotron, is designed and built at the Flerov Laboratory of Nuclear Reactions in collaboration with the Laboratory of High Energy Physics of JINR. The axial magnetic field of the source is created by the superconducting magnet and the NdFeB hexapole is used for the radial plasma confinement. The microwave frequency of 14 GHz is used for ECR plasma heating. During the first tests, the source shows a good enough performance for the production of medium charge state ions. In this paper, we will present the design parameters and the preliminary results with gaseous ions.

  9. Test plan for preliminary study of inorganic contaminant removal from RMA groundwater

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, D.; Terkonda, P.; Weeks, N.

    1978-02-01

    This document consists of a major report on inorganic contaminant removal from ground water. In this plan, WES has been requested by the OPM-CDIR to conduct a literature review and preliminary laboratory treatability studies on various source waters at RMA. Recommendation is that the determination of suitable treatment processes be based on both engineering and economic analysis and that the processes be compatible with the organic contaminant treatment processes under study (activated carbon adsorption and ultraviolet/ozone oxidation). The amendment to the test plan presents the inorganic treatment processes found from the literature to be applicable to the inorganic contaminants in RMA ground water and outlines the bench scale study to be conducted at WES using the potential processes. The rest of the document is correspondence and reports on various water treatability.

  10. Developing the Psychological Strain Scales (PSS): Reliability, Validity, and Preliminary Hypothesis Tests.

    Science.gov (United States)

    Zhang, Jie; Lu, Juncheng; Zhao, Sibo; Lamis, Dorian A; Li, Ning; Kong, Yuanyuan; Jia, Cunxian; Zhou, Li; Ma, Zhenyu

    2014-01-01

    Since its inception, the Strain Theory of Suicide has been tested and supported in a number of empirical studies. This social psychological theory can be employed as a complementary conceptualization to account for suicidal behaviors as well as mental disorders. However, the lack of consistent measurements of the strains limits the application of the theory in scientific research. Our research team has developed such scales for future testing of the Strain Theory of Suicide in a more systematic approach. For the initial items to measure the four strains (value, aspiration, deprivation, and coping), we solicited approximately 40 items for each strain with high face validity by about 30 fellow researchers. A preliminary examination of about 160 items for consistency and validity, with a sample of about 300 college students, yielded 20 consistent items for each of the four strain scales. Then, a second study was conducted at a different university with approximately 500 students to further streamline each of the four strain scales and test the validity of each with corresponding established scales and variables. As a result, 15 items were selected for each of the four Psychological Strain Scales (PSS). In correlation and multiple regression analyses, we found support for the hypotheses regarding the positive associations between psychological strains measured by the PSS and psychopathology including suicidal ideation. Follow up research with the new scales needs to be carried out in order to test the effects of psychological strains on suicide and mental disorders for various populations.

  11. A new airborne Polar Nephelometer for the measurement of optical and microphysical cloud properties. Part II: Preliminary tests

    Directory of Open Access Journals (Sweden)

    O. Crépel

    Full Text Available A new optical sensor, the airborne Polar Nephelometer, has been tested in an open wind tunnel. The wind tunnel was operated in cloudy conditions including either cloud water droplets or ice crystals, or a mixture of these particles. The sensor is designed to measure the optical and microphysical parameters of cloud particles sized from a few micrometers to about 500 µm diameter. Basically, the probe measures the scattering phase function of an ensemble of cloud particles which intersect a collimated laser beam near the focal point of a paraboloidal mirror. From the measured scattering phase function the retrieval of the droplet-size spectra and subsequent derived quantities such as liquid water content and size parameters can be calculated using an inversion method. The particle phase discrimination (water droplets/ice particles can be derived from the shape of the scattering phase function and the sensitivity of the probe allows the detection of small ice crystals (typically of 5 µm diameter. The paper describes the preliminary results obtained by the prototype version of the Polar Nephelometer in various cloudy conditions. These results are compared with direct microphysical measurements obtained by usual PMS probes also mounted in the wind tunnel. Complementary results obtained in a cold chamber are presented in order to illustrate the reliability of the Polar Nephelometer in the presence of small ice crystals.

  12. Post-operative orofacial pain, temporomandibular dysfunction and trigeminal sensitivity after recent pterional craniotomy: preliminary study.

    Science.gov (United States)

    Brazoloto, Thiago Medina; de Siqueira, Silvia Regina Dowgan Tesseroli; Rocha-Filho, Pedro Augusto Sampaio; Figueiredo, Eberval Gadelha; Teixeira, Manoel Jacobsen; de Siqueira, José Tadeu Tesseroli

    2017-05-01

    Surgical trauma at the temporalis muscle is a potential cause of post-craniotomy headache and temporomandibular disorders (TMD). The aim of this study was to evaluate the prevalence of pain, masticatory dysfunction and trigeminal somatosensory abnormalities in patients who acquired aneurysms following pterional craniotomy. Fifteen patients were evaluated before and after the surgical procedure by a trained dentist. The evaluation consisted of the (1) research diagnostic criteria for TMD, (2) a standardized orofacial pain questionnaire and (3) a systematic protocol for quantitative sensory testing (QST) for the trigeminal nerve. After pterional craniotomy, 80% of the subjects, 12 patients, developed orofacial pain triggered by mandibular function. The pain intensity was measured by using the visual analog scale (VAS), and the mean pain intensity was 3.7. The prevalence of masticatory dysfunction was 86.7%, and there was a significant reduction of the maximum mouth opening. The sensory evaluation showed tactile and thermal hypoesthesia in the area of pterional access in all patients. There was a high frequency of temporomandibular dysfunction, postoperative orofacial pain and trigeminal sensory abnormalities. These findings can help to understand several abnormalities that can contribute to postoperative headache or orofacial pain complaints after pterional surgeries.

  13. Quantitative wound healing studies using a portable, low cost, handheld near-infrared optical scanner: preliminary sensitivity and specificity analysis

    Science.gov (United States)

    Lei, Jiali; Rodriguez, Suset; Jayachandran, Maanasa; Solis, Elizabeth; Gonzalez, Stephanie; Perez-Clavijo, Francesco; Wigley, Stephen; Godavarty, Anuradha

    2016-03-01

    Lower extremity ulcers are devastating complications that are still un-recognized. To date, clinicians employ visual inspection of the wound site during its standard 4-week of healing process via monitoring of surface granulation. A novel ultra-portable near-infrared optical scanner (NIROS) has been developed at the Optical Imaging Laboratory that can perform non-contact 2D area imaging of the wound site. From preliminary studies it was observed that the nonhealing wounds had a greater absorption contrast with respect to the normal site, unlike in the healing wounds. Currently, non-contact near-infrared (NIR) imaging studies were carried out on 22 lower extremity wounds at two podiatric clinics, and the sensitivity and specificity of the scanner evaluated. A quantitative optical biometric was developed that differentiates healing from non-healing wounds, based on the threshold values obtained during ROC analysis. In addition, optical images of the wound obtained from weekly imaging studies are also assessed to determine the ability of the device to predict wound healing consistently on a periodic basis. This can potentially impact early intervention in the treatment of lower extremity ulcers when an objective and quantitative wound healing approach is developed. Lastly, the incorporation of MATLAB graphical user interface (GUI) to automate the process of image acquisition, image processing and image analysis realizes the potential of NIROS to perform non-contact and real-time imaging on lower extremity wounds.

  14. Test Prioritization based on Change Sensitivity: an Industrial Case Study

    NARCIS (Netherlands)

    Nguyen, Cu; Tonella, Paolo; Vos, Tanja; Condori, Nelly; Mendelson, Bilha; Citron, Daniel; Shehory, Onn

    2014-01-01

    In the context of service-based systems, applications access software services, either home-built or third-party, to orchestrate their functionality. Since such services evolve independently from the applications, the latter need to be tested to make sure that they work properly with the updated or

  15. On the reliability of sensitivity test methods for submicrometer-sized RDX and HMX particles

    NARCIS (Netherlands)

    Radacsi, N.; Bouma, R.H.B.; Krabbendam-La Haye, E.L.M.; Horst, J.H. ter; Stankiewicz, A.I.; Heijden, A.E.D.M. van der

    2013-01-01

    Submicrometer-sized RDX and HMX crystals were produced by electrospray crystallization and submicrometer-sized RDX crystals were produced by plasma-assisted crystallization. Impact and friction sensitivity tests and ballistic impact chamber tests were performed to determine the product sensitivity.

  16. On the reliability of sensitivity test methods for submicrometer-sized RDX and HMX particles

    NARCIS (Netherlands)

    Radacsi, N.; Bouma, R.H.B.; Krabbendam-La Haye, E.L.M.; Horst, J.H. ter; Stankiewicz, A.I.; Heijden, A.E.D.M. van der

    2013-01-01

    Submicrometer-sized RDX and HMX crystals were produced by electrospray crystallization and submicrometer-sized RDX crystals were produced by plasma-assisted crystallization. Impact and friction sensitivity tests and ballistic impact chamber tests were performed to determine the product sensitivity.

  17. Clinical evaluation of children testing positive in screening tests for attention-deficit/hyperactivity disorder: A preliminary report

    Directory of Open Access Journals (Sweden)

    Maria Skounti

    2009-06-01

    Full Text Available Background and Objectives: Screening tests are of great diagnostic value in attention-deficit/hyperactivity disorder (ADHD, however final diagnosis relies on a clinical examination by an expert. The objective of the present study was to clinically evaluate children who had been screened positive for ADHD through both a parent and a teacher questionnaire. Methods: Parent interview and child behavior checklist and clinical assessment were used to confirm the preliminary diagnosis in 42 children aged 8 years, who have been screened positive for ADHD out of 1,708 children, in a large, two-setting screening study conducted in Crete, Greece. Results: The diagnosis of ADHD was confirmed for 31 children (74%. In the remaining 11 children, ADHD manifestations were attributed to other primary disorders. None of the 42 children was classified as lacking symptoms suggesting ADHD. Among the 31 children with confirmed ADHD, only 2 had been diagnosed prior to the screening test. Conclusions: Although clinical evaluation is the golden standard for diagnosis of ADHD, two-setting screening questionnaires by parent and teacher are useful tools in identifying children who need further investigation and intervention.

  18. Cross-cultural effects on IQ test performance: a review and preliminary normative indications on WAIS-III test performance.

    Science.gov (United States)

    Shuttleworth-Edwards, Ann B; Kemp, Ryan D; Rust, Annegret L; Muirhead, Joanne G L; Hartman, Nigel P; Radloff, Sarah E

    2004-10-01

    This article presents a review of cross-cultural influences on Wechsler IQ tests, together with a preliminary investigation into WAIS-III test performance (English administration) for a southern African sample (age range 19-30) stratified for white English first language and black African first language, level and quality of education. ('African language' is the term used to denote the indigenous languages of black populations in southern Africa). A two-way ANOVA revealed highly significant effects for both level and quality of education within the black African first language group. Scores for the white English and black African first language groups with advantaged education were comparable with the US standardization, whereas scores for black African first language participants with disadvantaged education were significantly lower than this. Thus indications from this research are that normative studies should take account of the influential variable of quality of education, in addition to level of education. Alternatively faulty conclusions may be drawn about the effects of ethnicity, with the potential for neuropsychological misdiagnosis.

  19. Preliminary Tests Concerning Zero-Valent Iron Efficiency in Inorganic Pollutants Remediation

    Directory of Open Access Journals (Sweden)

    Silvia Fiore

    2009-01-01

    Full Text Available Problem statement: This study was aimed to a preliminary evaluation of the applicability of granular Zero-Valent Iron (ZVI to the on site remediation of groundwater polluted by inorganic contaminants by means of a Permeable Reactive Barrier (PRB. A particular interest was devoted to groundwater impacted by Acid Mine Drainage (AMD that was caused by the oxidation of metal sulphide minerals contained in mine wastes, especially iron disulphide pyrite. Although AMD consequences were particularly evident in surface waters, the percolation through mine wastes may heavily alter the groundwater quality, therefore is particularly important the development of a restrained cost remediation technique for groundwater polluted by AMDs. Approach: In this study the degradation efficiency of Brown size 8/50 ZVI (Peerless Powders and Abrasive Inc., Detroit, US was evaluated performing a leaching column test and analyzing the Oxidation Reduction Potential (ORP, metals, nitrates, chlorides and sulphates profiles along the column. Results: This test allowed simulating the solid-liquid contact characteristic of a real PRB behavior that proved to be a possible solution for the remediation of inorganic pollutants in groundwater. Conclusion: The considered material showed efficiency above 99% in metals removal, although further tests, involving biotic processes and more reducing conditions, are necessary to improve the degradation of sulphates and nitrates.

  20. Sensitivity of some asphalts to the wheel tracking test

    OpenAIRE

    Dubois, Vincent; DE LA ROCHE, Chantal; Buisson, Sébastien

    2008-01-01

    In the framework of LCPC fatigue carrousel studies [Corté and others, 1994; Gramsammer and others, 1994], rutting measurements on several mixes have been carried out. For each mix, the granular distribution has been identical, but different types of bitumen have been chosen : classical bitumen 50/70, EVA modified bitumen and SBS modified bitumen. These mixes have been designed by a previous laboratory tests campaign. In comparing field and laboratory results, a different behaviour is observed...

  1. NEW ANTIMICROBIAL SENSITIVITY TESTS OF BIOFILM OF STREPTOCOCCUS MUTANS IN ARTIFICIAL MOUTH MODEL

    Institute of Scientific and Technical Information of China (English)

    李鸣宇; 汪俊; 刘正; 朱彩莲

    2004-01-01

    Objective To develop a new antimicrobial sensitivity test model for oral products in vitro.Methods A biofilm artificial mouth model for antimicrobial sensitivity tests was established by modifying the LKI chromatography chamber. Using sodium fluoride and Tea polyphenol as antimicrobial agent and Streptococcus mutans as target, sensitivity tests were studied. Results The modeling biofilm assay resulted in a MIC of 1.28mg/ml for fluoride against S. mutans, which was 32 times the MIC for broth maco-dilution method. The differential resistance of bacteria bioflim to antimicrobial agent relative to planktonic cells was also demonstrated. Conclusion The biofilm artificial mouth model may be useful in oral products test.

  2. AGR-1 Irradiated Test Train Preliminary Inspection and Disassembly First Look

    Energy Technology Data Exchange (ETDEWEB)

    Paul Demkowicz; Lance Cole; Scott Ploger; Philip Winston; Binh Pham; Michael Abbott

    2011-01-01

    The AGR-1 irradiation experiment ended on November 6, 2009, after 620 effective full power days in the Advanced Test Reactor, achieving a peak burnup of 19.6% FIMA. The test train was shipped to the Materials and Fuels Complex in March 2010 for post-irradiation examination. The first PIE activities included non-destructive examination of the test train, followed by disassembly of the test train and individual capsules and detailed inspection of the capsule contents, including the fuel compacts and the graphite fuel holders. Dimensional measurements of the compacts, graphite holders, and steel capsules shells were performed using a custom vision measurement system (for outer diameters and lengths) and conventional bore gauges (for inner diameters). Gamma spectrometry of the intact test train gave a preliminary look at the condition of the interior components. No evidence of damage to compacts or graphite components was evident from the isotopic and gross gamma scans. Neutron radiography of the intact Capsule 2 showed a high degree of detail of interior components and confirmed the observation that there was no major damage to the capsule. Disassembly of the capsules was initiated using procedures qualified during out-of-cell mockup testing. Difficulties were encountered during capsule disassembly due to irradiation-induced changes in some of the capsule components’ properties, including embrittled niobium and molybdenum parts that were susceptible to fracture and swelling of the graphite fuel holders that affected their removal from the capsule shells. This required various improvised modifications to the disassembly procedure to avoid damage to the fuel compacts. Ultimately the capsule disassembly was successful and only one compact from Capsule 4 (out of 72 total in the test train) sustained damage during the disassembly process, along with the associated graphite holder. The compacts were generally in very good condition upon removal. Only relatively minor

  3. Preliminary test of an imaging probe for nuclear medicine using hybrid pixel detectors

    CERN Document Server

    Bertolucci, Ennio; Mettivier, G; Montesi, M C; Russo, P

    2002-01-01

    We are investigating the feasibility of an intraoperative imaging probe for lymphoscintigraphy with Tc-99m tracer, for sentinel node radioguided surgery, using the Medipix series of hybrid detectors coupled to a collimator. These detectors are pixelated semiconductor detectors bump-bonded to the Medipix1 photon counting read-out chip (64x64 pixel, 170 mu m pitch) or to the Medipix2 chip (256x256 pixel, 55 mu m pitch), developed by the European Medipix collaboration. The pixel detector we plan to use in the final version of the probe is a semi-insulating GaAs detector or a 1-2 mm thick CdZnTe detector. For the preliminary tests presented here, we used 300-mu m thick silicon detectors, hybridized via bump-bonding to the Medipix1 chip. We used a tungsten parallel-hole collimator (7 mm thick, matrix array of 64x64 100 mu m circular holes with 170 mu m pitch), and a 22, 60 and 122 keV point-like (1 mm diameter) radioactive sources, placed at various distances from the detector. These tests were conducted in order ...

  4. Preliminary failure modes and effects analysis on Korean HCCR TBS to be tested in ITER

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Mu-Young, E-mail: myahn74@nfri.re.kr [National Fusion Research Institute, Daejeon (Korea, Republic of); Cho, Seungyon [National Fusion Research Institute, Daejeon (Korea, Republic of); Jin, Hyung Gon; Lee, Dong Won [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Park, Yi-Hyun; Lee, Youngmin [National Fusion Research Institute, Daejeon (Korea, Republic of)

    2015-10-15

    Highlights: • Postulated initiating events are identified through failure modes and effects analysis on the current HCCR TBS design. • A set of postulated initiating events are selected for consideration of deterministic analysis. • Accident evolutions on the selected postualted initiating events are qualitatively described for deterministic analysis. - Abstract: Korean Helium cooled ceramic reflector (HCCR) Test blanket system (TBS), which comprises Test blanket module (TBM) and ancillary systems in various locations of ITER building, is operated at high temperature and pressure with decay heat. Therefore, safety is utmost concern in design process and it is required to demonstrate that the HCCR TBS is designed to comply with the safety requirements and guidelines of ITER. Due to complexity of the system with many interfaces with ITER, a systematic approach is necessary for safety analysis. This paper presents preliminary failure modes and effects analysis (FMEA) study performed for the HCCR TBS. FMEA is a systematic methodology in which failure modes for components in the system and their consequences are studied from the bottom-up. Over eighty failure modes have been investigated on the HCCR TBS. The failure modes that have similar consequences are grouped as postulated initiating events (PIEs) and total seven reference accident scenarios are derived from FMEA study for deterministic accident analysis. Failure modes not covered here due to evolving design of the HCCR TBS and uncertainty in maintenance procedures will be studied further in near future.

  5. New rapid test for prenatal detection of trisomy 21 (Down's syndrome): preliminary report.

    Science.gov (United States)

    Bryndorf, T.; Christensen, B.; Philip, J.; Hansen, W.; Yokobata, K.; Bui, N.; Gaiser, C.

    1992-01-01

    OBJECTIVE--To devise and evaluate a rapid screening method for detecting trisomy 21 (Down's syndrome) in samples of uncultured amniotic fluid cells. DESIGN--Non-radioactive in situ hybridisation with HY128, a 500,000 base pair yeast artificial chromosome probe specific for chromosome 21. Blinded study of 12 karyotypically normal amniotic fluid samples and eight samples trisomic for chromosome 21. SETTING--Cytogenetic and obstetric services at a tertiary referral centre, Copenhagen. MAIN OUTCOME MEASURES--Time necessary to complete the test. Proportion of cell nuclei containing two and three hybridisation signals in karyotypically normal and abnormal amniotic fluid samples. RESULTS--The test could be completed within three to four days after amniocentesis. In the normal samples a mean of 73% (range 61-82%) of the amniotic cell nuclei showed two hybridisation signals and 6% (0-18%) showed three signals. By contrast, among the trisomic samples 29% (19-38%) of the nuclei exhibited two signals and 48% (31-60%) showed three signals. CONCLUSION--The technique clearly distinguished between normal and trisomic samples. Prenatal diagnosis with in situ hybridisation with chromosome specific probes was fast and may make it possible to screen for selected, aneuploidies. However, the technique is still at a preliminary stage and needs further evaluation and refinement. Images p1537-a PMID:1385745

  6. Individual differences in left parietal white matter predict math scores on the Preliminary Scholastic Aptitude Test.

    Science.gov (United States)

    Matejko, Anna A; Price, Gavin R; Mazzocco, Michèle M M; Ansari, Daniel

    2013-02-01

    Mathematical skills are of critical importance, both academically and in everyday life. Neuroimaging research has primarily focused on the relationship between mathematical skills and functional brain activity. Comparatively few studies have examined which white matter regions support mathematical abilities. The current study uses diffusion tensor imaging (DTI) to test whether individual differences in white matter predict performance on the math subtest of the Preliminary Scholastic Aptitude Test (PSAT). Grades 10 and 11 PSAT scores were obtained from 30 young adults (ages 17-18) with wide-ranging math achievement levels. Tract based spatial statistics was used to examine the correlation between PSAT math scores, fractional anisotropy (FA), radial diffusivity (RD) and axial diffusivity (AD). FA in left parietal white matter was positively correlated with math PSAT scores (specifically in the left superior longitudinal fasciculus, left superior corona radiata, and left corticospinal tract) after controlling for chronological age and same grade PSAT critical reading scores. Furthermore, RD, but not AD, was correlated with PSAT math scores in these white matter microstructures. The negative correlation with RD further suggests that participants with higher PSAT math scores have greater white matter integrity in this region. Individual differences in FA and RD may reflect variability in experience dependent plasticity over the course of learning and development. These results are the first to demonstrate that individual differences in white matter are associated with mathematical abilities on a nationally administered scholastic aptitude measure.

  7. Using a situational judgement test for selection into dental core training: a preliminary analysis.

    Science.gov (United States)

    Rowett, E; Patterson, F; Cousans, F; Elley, K

    2017-05-12

    Objective and setting This paper describes the evaluation of a pilot situational judgement test (SJT) for selection into UK Dental Core Training (DCT). The SJT's psychometric properties, group differences based on gender and ethnicity, and candidate reactions were assessed.Methods The SJT targets four non-academic attributes important for success in DCT. Data were collected alongside live selection processes from five Health Education England local teams in the UK (N = 386). Candidates completed the pilot SJT and an evaluation questionnaire to examine their reactions to the test.Results SJT scores were relatively normally distributed and showed acceptable levels of internal reliability (α = 0.68). Difficulty level and partial correlations between scenarios and SJT total score were in the expected ranges (64.61% to 90.03% and r = 0.06 to 0.41, respectively). No group differences were found for gender, and group differences between White and BME candidates were minimal. Most candidates perceived the SJT as relevant to the target role, appropriate and fair.Conclusions This study demonstrated the potential suitability of an SJT for use in DCT selection. Future research should replicate these preliminary findings in other cohorts, and assess the predictive validity of the SJT for predicting key training and practice-based outcomes.

  8. Age Sensitivity of Behavioral Tests and Brain Substrates of Normal Aging in Mice

    OpenAIRE

    Kennard, John A.; Woodruff-Pak, Diana S.

    2011-01-01

    Knowledge of age sensitivity, the capacity of a behavioral test to reliably detect age-related changes, has utility in the design of experiments to elucidate processes of normal aging. We review the application of these tests in studies of normal aging and compare and contrast the age sensitivity of the Barnes maze, eyeblink classical conditioning, fear conditioning, Morris water maze, and rotorod. These tests have all been implemented to assess normal age-related changes in learning and memo...

  9. Sensitization capacity of acrylated prepolymers in ultraviolet curing inks tested in the guinea pig.

    Science.gov (United States)

    Björkner, B

    1981-01-01

    One commonly used prepolymer in ultraviolet (UV) curing inks is epoxy acrylate. Of 6 men with dermatitis contracted from UV-curing inks, 2 had positive patch test reaction to epoxy acrylate. None reacted to the chemically related bisphenol A dimethacrylate. The sensitization capacity of epoxy acrylate and bisphenol A dimethacrylate performed with the "Guinea pig maximization test" (GPM) shows epoxy acrylate to be an extreme sensitizer and bisphenol A dimethacrylate a moderate sensitizer. Cross-reaction between the two substances occurs. The epoxy resin oligomer MW 340 present in the epoxy acrylate also sensitized some animals.

  10. A Job-Seeking Self-Efficacy Scale for People with Physical Disabilities: Preliminary Development and Psychometric Testing.

    Science.gov (United States)

    Barlow, Julie; Wright, Chris; Cullen, Lesley

    2002-01-01

    Study sought to develop and conduct preliminary testing of the psychometric properties of a job-seeking self-efficacy (JSS) scale that reflected the experiences of people with physical disabilities. Greater job seeking self-efficacy and perceived ability to manage disability at interview were associated with more positive psychological well-being.…

  11. Speech and Pause Characteristics in Multiple Sclerosis: A Preliminary Study of Speakers with High and Low Neuropsychological Test Performance

    Science.gov (United States)

    Feenaughty, Lynda; Tjaden, Kris; Benedict, Ralph H. B.; Weinstock-Guttman, Bianca

    2013-01-01

    This preliminary study investigated how cognitive-linguistic status in multiple sclerosis (MS) is reflected in two speech tasks (i.e. oral reading, narrative) that differ in cognitive-linguistic demand. Twenty individuals with MS were selected to comprise High and Low performance groups based on clinical tests of executive function and information…

  12. Design and preliminary test of a free-air ionization chamber for low-energy X-ray

    Institute of Scientific and Technical Information of China (English)

    吴金杰; 杨元第; 王培玮; 陈靖; 柳加成

    2011-01-01

    A free-air ionization chamber in low-energy X-ray has been designed and manufactured at the National Institute of Metrology (NIM, China) according to the defination of air-kerma. The results of a preliminary test show that the leakage current of ionizatio

  13. Preliminary Tests For Development Of A Non-Pertechnetate Analysis Method

    Energy Technology Data Exchange (ETDEWEB)

    Diprete, D. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); McCabe, D. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2016-09-28

    The objective of this task was to develop a non-pertechnetate analysis method that 222-S lab could easily implement. The initial scope involved working with 222-S laboratory personnel to adapt the existing Tc analytical method to fractionate the non-pertechnetate and pertechnetate. SRNL then developed and tested a method using commercial sorbents containing Aliquat® 336 to extract the pertechnetate (thereby separating it from non-pertechnetate), followed by oxidation, extraction, and stripping steps, and finally analysis by beta counting and Mass Spectroscopy. Several additional items were partially investigated, including impacts of a 137Cs removal step. The method was initially tested on SRS tank waste samples to determine its viability. Although SRS tank waste does not contain non-pertechnetate, testing with it was useful to investigate the compatibility, separation efficiency, interference removal efficacy, and method sensitivity.

  14. Preliminary Tests For Development Of A Non-Pertechnetate Analysis Method

    Energy Technology Data Exchange (ETDEWEB)

    Diprete, D. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); McCabe, D. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2016-09-28

    The objective of this task was to develop a non-pertechnetate analysis method that 222-S lab could easily implement. The initial scope involved working with 222-S laboratory personnel to adapt the existing Tc analytical method to fractionate the non-pertechnetate and pertechnetate. SRNL then developed and tested amethod using commercial sorbents containing Aliquat® 336 to extract the pertechnetate (thereby separating it from non-pertechnetate), followed by oxidation, extraction, and stripping steps, and finally analysis by beta counting and Mass Spectroscopy. Several additional items were partially investigated, including impacts of a 137Cs removal step. The method was initially tested on SRS tank waste samples to determine its viability. Although SRS tank waste does not contain non-pertechnetate, testing with it was useful to investigate the compatibility, separation efficiency, interference removal efficacy, and method sensitivity.

  15. AGR-2 Irradiated Test Train Preliminary Inspection and Disassembly First Look

    Energy Technology Data Exchange (ETDEWEB)

    Ploger, Scott [Idaho National Lab. (INL), Idaho Falls, ID (United States); Demkowciz, Paul [Idaho National Lab. (INL), Idaho Falls, ID (United States); Harp, Jason [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-05-01

    The AGR 2 irradiation experiment began in June 2010 and was completed in October 2013. The test train was shipped to the Materials and Fuels Complex in July 2014 for post-irradiation examination (PIE). The first PIE activities included nondestructive examination of the test train, followed by disassembly of the test train and individual capsules and detailed inspection of the capsule contents, including the fuel compacts and their graphite fuel holders. Dimensional metrology was then performed on the compacts, graphite holders, and steel capsule shells. AGR 2 disassembly and metrology were performed with the same equipment used successfully on AGR 1 test train components. Gamma spectrometry of the intact test train gave a preliminary look at the condition of the interior components. No evidence of damage to compacts or graphite components was evident from the isotopic and gross gamma scans. Disassembly of the AGR 2 test train and its capsules was conducted rapidly and efficiently by employing techniques refined during the AGR 1 disassembly campaign. Only one major difficulty was encountered while separating the test train into capsules when thermocouples (of larger diameter than used in AGR 1) and gas lines jammed inside the through tubes of the upper capsules, which required new tooling for extraction. Disassembly of individual capsules was straightforward with only a few minor complications. On the whole, AGR 2 capsule structural components appeared less embrittled than their AGR 1 counterparts. Compacts from AGR 2 Capsules 2, 3, 5, and 6 were in very good condition upon removal. Only relatively minor damage or markings were visible using high resolution photographic inspection. Compact dimensional measurements indicated radial shrinkage between 0.8 to 1.7%, with the greatest shrinkage observed on Capsule 2 compacts that were irradiated at higher temperature. Length shrinkage ranged from 0.1 to 0.9%, with by far the lowest axial shrinkage on Capsule 3 compacts

  16. Sensitivity and specificity of point-of-care rapid combination syphilis-HIV-HCV tests.

    Directory of Open Access Journals (Sweden)

    Kristen L Hess

    Full Text Available New rapid point-of-care (POC tests are being developed that would offer the opportunity to increase screening and treatment of several infections, including syphilis. This study evaluated three of these new rapid POC tests at a site in Southern California.Participants were recruited from a testing center in Long Beach, California. A whole blood specimen was used to evaluate the performance of the Dual Path Platform (DPP Syphilis Screen & Confirm, DPP HIV-Syphilis, and DPP HIV-HCV-Syphilis rapid tests. The gold-standard comparisons were Treponema pallidum passive particle agglutination (TPPA, rapid plasma reagin (RPR, HCV enzyme immunoassay (EIA, and HIV-1/2 EIA.A total of 948 whole blood specimens were analyzed in this study. The sensitivity of the HIV tests ranged from 95.7-100% and the specificity was 99.7-100%. The sensitivity and specificity of the HCV test were 91.8% and 99.3%, respectively. The treponemal-test sensitivity when compared to TPPA ranged from 44.0-52.7% and specificity was 98.7-99.6%. The non-treponemal test sensitivity and specificity when compared to RPR was 47.8% and 98.9%, respectively. The sensitivity of the Screen & Confirm test improved to 90.0% when cases who were both treponemal and nontreponemal positive were compared to TPPA+/RPR ≥ 1 ∶ 8.The HIV and HCV on the multi-infection tests showed good performance, but the treponemal and nontreponemal tests had low sensitivity. These results could be due to a low prevalence of active syphilis in the sample population because the sensitivity improved when the gold standard was limited to those more likely to be active cases. Further evaluation of the new syphilis POC tests is required before implementation into testing programs.

  17. Preliminary Analysis of the Transient Reactor Test Facility (TREAT) with PROTEUS

    Energy Technology Data Exchange (ETDEWEB)

    Connaway, H. M. [Argonne National Lab. (ANL), Argonne, IL (United States); Lee, C. H. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2015-11-30

    The neutron transport code PROTEUS has been used to perform preliminary simulations of the Transient Reactor Test Facility (TREAT). TREAT is an experimental reactor designed for the testing of nuclear fuels and other materials under transient conditions. It operated from 1959 to 1994, when it was placed on non-operational standby. The restart of TREAT to support the U.S. Department of Energy’s resumption of transient testing is currently underway. Both single assembly and assembly-homogenized full core models have been evaluated. Simulations were performed using a historic set of WIMS-ANL-generated cross-sections as well as a new set of Serpent-generated cross-sections. To support this work, further analyses were also performed using additional codes in order to investigate particular aspects of TREAT modeling. DIF3D and the Monte-Carlo codes MCNP and Serpent were utilized in these studies. MCNP and Serpent were used to evaluate the effect of geometry homogenization on the simulation results and to support code-to-code comparisons. New meshes for the PROTEUS simulations were created using the CUBIT toolkit, with additional meshes generated via conversion of selected DIF3D models to support code-to-code verifications. All current analyses have focused on code-to-code verifications, with additional verification and validation studies planned. The analysis of TREAT with PROTEUS-SN is an ongoing project. This report documents the studies that have been performed thus far, and highlights key challenges to address in future work.

  18. Bridging the gap: Research and validation of the DST (Dynamic System Testing) performance test method for CE and ISO standards. Progress and preliminary results

    NARCIS (Netherlands)

    Naron, D.J.; Ree, B.G.C. van der; Rolloos, M.

    1998-01-01

    The Dynamic System Testing (DST) method is one of the methods chosen in the preliminary CEN/TC 312 European quality standards [1 ] to measure the energetic performance of Solar Domestic Hot Water (SDHW) systems. These European standards make a reference to the DST procedure as defined in the Draft I

  19. Hyperacuity test to evaluate vision through dense cataracts: research preliminary to a clinical study in India

    Science.gov (United States)

    Enoch, Jay M.; Giraldez, Maria J.; Huang, Doahua; Hirose, Hiroshi; Knowles, Richard A.; Namperumalsamy, P.; LaBree, Lauri; Azen, Stanley P.

    1995-03-01

    Using high luminance point-of-light stimuli, Vernier judgments can be made in the presence of markedly degraded retinal imagery. Without coaching, observers perform center-of-gravity assessments of relative locations of degraded point images. We seek to defined, presurgery, individuals who will derive the most benefit from advanced cataract removal (a form of triage), and to determine which of two cataractous eyes has the better postsurgical visual prognosis. There are incredible and growing backlogs of patients with severe cataracts (and other dense media opacities) in the developing world, and generally, limited resources are available for provision of health care. Postcataract surgical failure rates for good visual function are often high, and only one eye is operated on in over 95% of indigent patients treated. Prior to initiating advanced studies in the developing world, at Berkeley we conducted preliminary research on Vernier acuity test techniques on normal adult subjects. We sought to determine the number of repeat trials necessary; to compare a two-point and a three-point Vernier display; to determine the shape of the measured response function at large gap separations between test points (required when testing advanced cataract patients); to assess the effect(s) of a broad range of uncorrected refractive errors on outcomes; and to consider means to minimize refraction-based errors. From these and prior data and analyses, we defined a protocol for use in the developing world. Using a newly designed and rugged precision instrument, these tests were repeated on an advanced cataract population at Aravind Eye Hospital in Madurai, India. Although we had much prior experience in India, the initial protocol required major revision on site. Necessary changes in test methods and analytical approaches were made, and next stages in this program were planned. And a new and simple gap `visual acuity' (gap `VA') test was added to the protocol, which greatly facilitated

  20. Jaw-opening force test to screen for Dysphagia: preliminary results.

    Science.gov (United States)

    Hara, Koji; Tohara, Haruka; Wada, Satoko; Iida, Takatoshi; Ueda, Koichiro; Ansai, Toshihiro

    2014-05-01

    To assess the jaw-opening force test (JOFT) for dysphagia screening. Criterion standard. University dental hospital. Patients complaining of dysphagia (N=95) and with symptoms of dysphagia with chronic underlying causes (mean age ± SD, 79.3±9.61y; range, 50-94y; men: n=49; mean age ± SD, 77.03±9.81y; range, 50-94y; women: n=46; mean age ± SD, 75.42±9.73y; range, 51-93y) admitted for treatment between May 2011 and December 2012 were included. None. All patients were administered the JOFT and underwent fiberoptic endoscopic evaluation of swallowing (FEES). The mean jaw-opening strength was compared with aspiration (ASP) and pharyngeal residue observations of the FEES, which was used as the criterion standard. A receiver operating characteristic (ROC) curve analysis was performed. Forces of ≤3.2kg for men and ≤4kg for women were appropriate cutoff values for predicting ASP with a sensitivity and specificity of .57 and .79 for men and .93 and .52 for women, respectively. Based on the ROC analyses for predicting pharyngeal residue, forces of ≤5.3kg in men and ≤3.9kg in women were appropriate cutoff values, with a sensitivity and specificity of .80 and .88 for men and .83 and .81 for women, respectively. The JOFT could be a useful screening tool for predicting pharyngeal residue and could provide useful information to aid in the referral of patients for further diagnostic imaging testing. However, given its low sensitivity to ASP the JOFT should be paired with other screening tests that predict ASP. Copyright © 2014 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

  1. Preliminary Flight Results of the Microelectronics and Photonics Test Bed: NASA DR1773 Fiber Optic Data Bus Experiment

    Science.gov (United States)

    Jackson, George L.; LaBel, Kenneth A.; Marshall, Cheryl; Barth, Janet; Seidleck, Christina; Marshall, Paul

    1998-01-01

    NASA Goddard Spare Flight Center's (GSFC) Dual Rate 1773 (DR1773) Experiment on the Microelectronic and Photonic Test Bed (MPTB) has provided valuable information on the performance of the AS 1773 fiber optic data bus in the space radiation environment. Correlation of preliminary experiment data to ground based radiation test results show the AS 1773 bus is employable in future spacecraft applications requiring radiation tolerant communication links.

  2. A smartphone-based platform to test the performance of wireless mobile networks and preliminary findings

    Science.gov (United States)

    Geng, Xinli; Xu, Hao; Qin, Xiaowei

    2016-10-01

    During the last several years, the amount of wireless network traffic data increased fast and relative technologies evolved rapidly. In order to improve the performance and Quality of Experience (QoE) of wireless network services, the analysis of field network data and existing delivery mechanisms comes to be a promising research topic. In order to achieve this goal, a smartphone based platform named Monitor and Diagnosis of Mobile Applications (MDMA) was developed to collect field data. Based on this tool, the web browsing service of High Speed Downlink Packet Access (HSDPA) network was tested. The top 200 popular websites in China were selected and loaded on smartphone for thousands times automatically. Communication packets between the smartphone and the cell station were captured for various scenarios (e.g. residential area, urban roads, bus station etc.) in the selected city. A cross-layer database was constructed to support the off-line analysis. Based on the results of client-side experiments and analysis, the usability of proposed portable tool was verified. The preliminary findings and results for existing web browsing service were also presented.

  3. Augmented Reality Cubes for Cognitive Gaming: Preliminary Usability and Game Experience Testing

    Directory of Open Access Journals (Sweden)

    Costas Boletsis

    2016-03-01

    Full Text Available Early detection is important in dementia care; however, cognitive impairment is still under-recognised and under-diagnosed. Cognitive screening and training are two important preventative treatments, which can lead to early detection of cognitive decline. In this work, the “Cognitive Augmented Reality Cubes” (CogARC system is presented, i.e. a serious game for cognitive training and screening, utilising an interaction technique based on Augmented Reality and the manipulation of tangible, physical objects (cubes. The game is a collection of cognitive mini-games of preventative nature and is, primarily, targeting elderly players (≥60 years old. A preliminary testing was conducted focusing on the game experience that CogARC offers (utilising the In-Game Experience Questionnaire, the usability of the system (using the System Usability Scale, and the specific user observations and remarks, as documented by open, semi-structured interviews.  Overall, CogARC demonstrated satisfying positive responses, however, the negative reactions indicated that there are specific problems with aspects of the interaction technique and a number of mini-games. The open interview shed more light on the specific issues of each mini-game and further interpretation of user interactions. The current study managed to provide interesting insights into the game design elements, integration of Augmented Reality, tangible interaction of the system, and on how elderly players perceive and use those interaction components. 

  4. A soft wearable robot for the shoulder: Design, characterization, and preliminary testing.

    Science.gov (United States)

    O'Neill, Ciaran T; Phipps, Nathan S; Cappello, Leonardo; Paganoni, Sabrina; Walsh, Conor J

    2017-07-01

    In this paper, we present a soft wearable robot for the shoulder which has the potential to assist individuals suffering from a range of neuromuscular conditions affecting the shoulder to perform activities of daily living. This wearable robot combines two types of soft textile pneumatic actuators which were custom developed for this particular application to support the upper arm through shoulder abduction and horizontal flexion/extension. The advantage of a textile-based approach is that the robot can be lightweight, low-profile, comfortable and non-restrictive to the wearer, and easy to don like an item of clothing. The actuator's ability to fold flat when not in use allows the robot to be almost invisible under clothing, potentially allowing the user to avoid any stigma associated with using assistive devices in public. To abduct the arm, a textilebased pneumatic actuator was developed to fit within the axilla to push the arm upwards, while a pair of smaller actuators pivot the abduction actuator to allow for horizontal extension and flexion. The individual textile actuators were experimentally evaluated before being integrated into a wearable garment. Human subject testing was performed to evaluate the ability of the robot to assist the arm by monitoring changes in biological muscle activity when comparing the robot powered on and off. Preliminary results show large reductions in muscular effort in targeted muscles, demonstrating the feasibility and promise of such a soft wearable robot for the shoulder.

  5. Soda-Anthraquinone Durian (Durio Zibethinus Murr.) Rind Linerboard and Corrugated Medium Paper: A Preliminary Test

    Science.gov (United States)

    Rizal Masrol, Shaiful; Irwan Ibrahim, Mohd Halim; Adnan, Sharmiza; Mubarak Sa'adon, Amir; Ika Sukarno, Khairil; Fadrol Hisham Yusoff, Mohd

    2017-08-01

    A preliminary test was conducted to investigate the characteristics of linerboard and corrugated medium paper made from durian rind waste. Naturally dried durian rinds were pulped according to Soda-Anthraquinone (Soda-AQ) pulping process with a condition of 20% active alkali, 0.1% AQ, 7:1 liquor to material ratio, 120 minutes cooking time and 170°C cooking temperature. The linerboard and corrugated medium paper with a basis weight of 120 gsm were prepared and evaluated according to Malaysian International Organization for Standardization (MS ISO) and Technical Association of the Pulp and Paper Industry (TAPPI). The results indicate that the characteristics of durian rind linerboard are comparable with other wood or non-wood based paper and current commercial paper. However, low CMT value for corrugated medium and water absorptiveness quality for linerboard could be improved in future. Based on the bulk density (0.672 g/cm3), burst index (3.12 kPa.m2/g) and RCT (2.00 N.m2/g), the durian rind has shown a good potential and suitable as an alternative raw material source for linerboard industry.

  6. Preliminary Tests of Cellular SiC/Iron Alloy Composite Produced by a Pressureless Infiltration Technique

    Directory of Open Access Journals (Sweden)

    Lipowska B.

    2017-03-01

    Full Text Available Preliminary tests aimed at obtaining a cellular SiC/iron alloy composite with a spatial structure of mutually intersecting skeletons, using a porous ceramic preform have been conducted. The possibility of obtaining such a composite joint using a SiC material with an oxynitride bonding and grey cast iron with flake graphite has been confirmed. Porous ceramic preforms were made by pouring the gelling ceramic suspension over a foamed polymer base which was next fired. The obtained samples of materials were subjected to macroscopic and microscopic observations as well as investigations into the chemical composition in microareas. It was found that the minimum width of a channel in the preform, which in the case of pressureless infiltration enables molten cast iron penetration, ranges from 0.10 to 0.17 mm. It was also found that the ceramic material applied was characterized by good metal wettability. The ceramics/metal contact area always has a transition zone (when the channel width is big enough, where mixing of the components of both composite elements takes place.

  7. Improved sensitivity testing of explosives using transformed Up-Down methods

    Science.gov (United States)

    Brown, Geoffrey W.

    2014-05-01

    Sensitivity tests provide data that help establish guidelines for the safe handling of explosives. Any sensitivity test is based on assumptions to simplify the method or reduce the number of individual sample evaluations. Two common assumptions that are not typically checked after testing are 1) explosive response follows a normal distribution as a function of the applied stimulus levels and 2) the chosen test level spacing is close to the standard deviation of the explosive response function (for Bruceton Up-Down testing for example). These assumptions and other limitations of traditional explosive sensitivity testing can be addressed using Transformed Up-Down (TUD) test methods. TUD methods have been developed extensively for psychometric testing over the past 50 years and generally use multiple tests at a given level to determine how to adjust the applied stimulus. In the context of explosive sensitivity we can use TUD methods that concentrate testing around useful probability levels. Here, these methods are explained and compared to Bruceton Up-Down testing using computer simulation. The results show that the TUD methods are more useful for many cases but that they do require more tests as a consequence. For non-normal distributions, however, the TUD methods may be the only accurate assessment method.

  8. Parametric Sensitivity Tests—European Polymer Electrolyte Membrane Fuel Cell Stack Test Procedures

    DEFF Research Database (Denmark)

    Araya, Samuel Simon; Andreasen, Søren Juhl; Kær, Søren Knudsen

    2014-01-01

    As fuel cells are increasingly commercialized for various applications, harmonized and industry-relevant test procedures are necessary to benchmark tests and to ensure comparability of stack performance results from different parties. This paper reports the results of parametric sensitivity tests...

  9. 75 FR 35712 - National Pollutant Discharge Elimination System (NPDES): Use of Sufficiently Sensitive Test...

    Science.gov (United States)

    2010-06-23

    ... sensitive'' analytical methods with respect to measurement of mercury and extend the approach outlined in...): Use of Sufficiently Sensitive Test Methods for Permit Applications and Reporting AGENCY: Environmental... methods can be used when completing an NPDES permit application and when performing sampling and...

  10. Integrating non-animal test information into an adaptive testing strategy - skin sensitization proof of concept case.

    Science.gov (United States)

    Jaworska, Joanna; Harol, Artsiom; Kern, Petra S; Gerberick, G Frank

    2011-01-01

    There is an urgent need to develop data integration and testing strategy frameworks allowing interpretation of results from animal alternative test batteries. To this end, we developed a Bayesian Network Integrated Testing Strategy (BN ITS) with the goal to estimate skin sensitization hazard as a test case of previously developed concepts (Jaworska et al., 2010). The BN ITS combines in silico, in chemico, and in vitro data related to skin penetration, peptide reactivity, and dendritic cell activation, and guides testing strategy by Value of Information (VoI). The approach offers novel insights into testing strategies: there is no one best testing strategy, but the optimal sequence of tests depends on information at hand, and is chemical-specific. Thus, a single generic set of tests as a replacement strategy is unlikely to be most effective. BN ITS offers the possibility of evaluating the impact of generating additional data on the target information uncertainty reduction before testing is commenced.

  11. Can Artemia Hatching Assay Be a (Sensitive) Alternative Tool to Acute Toxicity Test?

    Science.gov (United States)

    Rotini, A; Manfra, L; Canepa, S; Tornambè, A; Migliore, L

    2015-12-01

    Artemia sp. is extensively used in ecotoxicity testing, despite criticisms inherent to both acute and long-term tests. Alternative endpoints and procedures should be considered to support the use of this biological model. The hatching process comprises several developmental steps and the cyst hatchability seems acceptable as endpoint criterion. In this study, we assessed the reliability of the hatching assay on A. franciscana by comparing with acute and long-term mortality tests, using two chemicals: Diethylene Glycol (DEG), Sodium Dodecyl Sulphate (SDS). Both DEG and SDS tests demonstrated a dose dependent hatching inhibition. The hatching test resulted more sensitive than acute mortality test and less sensitive than the long-term one. Results demonstrate the reliability and high sensitivity of this hatching assay on a short time lag and support its useful application in first-tier risk assessment procedures.

  12. Repeated patch testing to nickel during childhood do not induce nickel sensitization

    DEFF Research Database (Denmark)

    Søgaard Christiansen, Elisabeth

    2014-01-01

    Background: Previously, patch test reactivity to nickel sulphate in a cohort of unselected infants tested repeatedly at 3-72 months of age has been reported. A reproducible positive reaction at 12 and 18 months was selected as a sign of nickel sensitivity, provided a patch test with an empty Finn...... chamber was negative. The objective of this study is to follow-up on infants with suspected nickel sensitivity. Methods: A total of 562 infants were included in the cohort and patch tested with nickel sulphate. The 26 children with a positive patch test to nickel sulphate at 12 and 18 months were offered...... repeated patch test to nickel sulphate at 3 (36 months), 6 (72 months) and 14 years of age. Results: At 3 years, 24 of 26 nickel sensitive children were retested and a positive reaction was seen in 7 children, a negative reaction in 16 and 1 child was excluded due to reaction to both nickel and the empty...

  13. Patient empowerment in long-term conditions: development and preliminary testing of a new measure.

    Science.gov (United States)

    Small, Nicola; Bower, Peter; Chew-Graham, Carolyn A; Whalley, Diane; Protheroe, Joanne

    2013-07-08

    Patient empowerment is viewed by policy makers and health care practitioners as a mechanism to help patients with long-term conditions better manage their health and achieve better outcomes. However, assessing the role of empowerment is dependent on effective measures of empowerment. Although many measures of empowerment exist, no measure has been developed specifically for patients with long-term conditions in the primary care setting. This study presents preliminary data on the development and validation of such a measure. We conducted two empirical studies. Study one was an interview study to understand empowerment from the perspective of patients living with long-term conditions. Qualitative analysis identified dimensions of empowerment, and the qualitative data were used to generate items relating to these dimensions. Study two was a cross-sectional postal study involving patients with different types of long-term conditions recruited from general practices. The survey was conducted to test and validate our new measure of empowerment. Factor analysis and regression were performed to test scale structure, internal consistency and construct validity. Sixteen predominately elderly patients with different types of long-term conditions described empowerment in terms of 5 dimensions (identity, knowledge and understanding, personal control, personal decision-making, and enabling other patients). One hundred and ninety seven survey responses were received from mainly older white females, with relatively low levels of formal education, with the majority retired from paid work. Almost half of the sample reported cardiovascular, joint or diabetes long-term conditions. Factor analysis identified a three factor solution (positive attitude and sense of control, knowledge and confidence in decision making and enabling others), although the structure lacked clarity. A total empowerment score across all items showed acceptable levels of internal consistency and relationships

  14. Scintigraphic test of gastric emptying and motility: preliminary results in patients with chronic gastritis

    Energy Technology Data Exchange (ETDEWEB)

    Hausmann, T. [Abt. Nuklearmedizin und Spezielle Biophysik, Medizinische Hochschule Hannover (Germany); Mueller-Schauenburg, W. [Abt. Nuklearmedizin, Univ. Tuebingen (Germany); Goeke, M. [Abt. Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover (Germany); Luebeck, M. [Abt. Nuklearmedizin, Univ.-Krankenhaus Eppendorf, Hamburg (Germany); Gratz, K.F. [Abt. Nuklearmedizin und Spezielle Biophysik, Medizinische Hochschule Hannover (Germany); Meier, P. [Abt. Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover (Germany); Manns, M. [Abt. Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover (Germany); Hundeshagen, H. [Abt. Nuklearmedizin und Spezielle Biophysik, Medizinische Hochschule Hannover (Germany)

    1995-11-01

    To record gastric peristalsis using a conventional scintigraphic gastric emptying test the frame rate was increased to 1 frame per 3 s at 10, 30, and 50 min postprandially. The gastric contraction frequency was obtained from the first harmonic of a Fourier transform of a gastric region of interest (ROI) curve. The propagation of gastric contractions was better revealed from computed functional images of the phase and amplitude distribution as compared with the multiple scintigraphic images. The maximal count-rate changes per pixel were calculated as an estimate of the most prominent regional contractile activity of the gastric wall. Among 12 patients with chronic gastritis the group with more severe dyspeptic complaints (n = 6) had significantly higher count-rate changes per pixel when compared with the group with minor complaints (20.0, 21.1 and 14.2 vs 12.9, 12.0, and 10.4 counts/pixel X s at 10, 30, and 50 min. respectively; p < 0.05). The mean half-times of gastric emptying (61, SD 11 vs 54, SD 13 min) and the mean gastric contraction frequencies (2.99, SD 0.19; 3.09, SD 0.33; 3.07, SD 0.10 vs 3.15, SD 0.15; 3.17, SD 0.13; 3.23, SD 0.20 cycles/min at 10, 30, and 50 min, respectively) did not show significant differences between both groups. Our preliminary results agree with the hypothesis of the occurrence of more powerful, nonexpulsive gastric-wall contractions in patients with more severe dyspeptic complaints. Hence, additional quantification of gastric motility allowed a more detailed evaluation of gastric-motor-activity disorders that were for so long not accessible to conventional gastric-emptying tests. (orig.)

  15. Skin Prick Test Analysis in Allergic Rhinitis Patients: A Preliminary Study in Abuja, Nigeria

    Directory of Open Access Journals (Sweden)

    P. U. Ibekwe

    2016-01-01

    Full Text Available Allergic rhinitis (AR is prevalent in Nigeria, though little information exists on the allergen. We assessed the clinical features of AR patients in our environment based on the allergic rhinitis impact on asthma (ARIA classification. Only patients with positive skin prick test (SPT were recruited. Seventy-four patients participated in the study. AR and asthma comorbidity were observed in 13.5%. The proportion of “sneezers-runners” was higher than “blockers” with significantly more “sneezers-runners” having persistent AR (P=0.007. No relationship was established between these predominant symptoms and the aeroallergens used in this study. Intermittent mild and moderate/severe AR were evident in 13.5% and 31.1%, while persistent mild and moderate/severe were seen in 20.3% and 35.1%, respectively. House dust mites allergen yielded the highest number of positive responses (22.6% followed by tree pollen (16.8%. No relationship was observed between the allergens tested and AR severity. Majority of patients were oligosensitive (33.8% and polysensitive (35.1% and were not significantly associated with AR severity (P=0.07. Most AR patients presenting for treatment in Abuja, Nigeria, had moderate-severe persistent AR and showed similar SPT sensitization pattern with countries having similar climatic conditions. Sensitization patterns were not related to ARIA classification or predominant AR symptoms.

  16. Bioluminometric assay of ATP in mouse brain: Determinant factors for enhanced test sensitivity

    Indian Academy of Sciences (India)

    Haseeb Ahmad Khan

    2003-06-01

    Firefly luciferase bioluminescence (FLB) is a highly sensitive and specific method for the analysis of adenosine-5-triphosphate (ATP) in biological samples. Earlier attempts to modify the FLB test for enhanced sensitivity have been typically based on in vitro cell systems. This study reports an optimized FLB procedure for the analysis of ATP in small tissue samples. The results showed that the sensitivity of the FLB test can be enhanced several fold by using ultraturax homogenizer, perchloric acid extraction, neutralization of acid extract and its optimal dilution, before performing the assay reaction.

  17. Maternal sensitivity and language in early childhood: a test of the transactional model.

    Science.gov (United States)

    Leigh, Patricia; Nievar, M Angela; Nathans, Laura

    2011-08-01

    This study examined the relation between mothers' sensitive responsiveness to their children and the children's expressive language skills during early childhood. Reciprocal effects were tested with dyads of mothers and their children participating in the National Institute of Health and Human Development Study of Early Child Care and Youth Development. Sensitive maternal interactions positively affected children's later expressive language in the second and third years of life. Although maternal sensitivity predicted later language skills in children, children's language did not affect later maternal sensitivity as indicated in a structural equation model. These results do not support the 1975 transactional model of child development of Sameroff and Chandler. A consistent pattern of sensitivity throughout infancy and early childhood indicates the importance of fostering maternal sensitivity in infancy for prevention or remediation of expressive language problems in young children.

  18. Effect of test duration and feeding on relative sensitivity of genetically distinct clades of Hyalella azteca.

    Science.gov (United States)

    Soucek, David J; Dickinson, Amy; Major, Kaley M; McEwen, Abigail R

    2013-11-01

    The amphipod Hyalella azteca is widely used in ecotoxicology laboratories for the assessment of chemical risks to aquatic environments, and it is a cryptic species complex with a number of genetically distinct strains found in wild populations. While it would be valuable to note differences in contaminant sensitivity among different strains collected from various field sites, those findings would be influenced by acclimation of the populations to local conditions. In addition, potential differences in metabolism or lipid storage among different strains may confound assessment of sensitivity in unfed acute toxicity tests. In the present study, our aim was to assess whether there are genetic differences in contaminant sensitivity among three cryptic provisional species of H. azteca. Therefore, we used organisms cultured under the same conditions, assessed their ability to survive for extended periods without food, and conducted fed and unfed acute toxicity tests with two anions (nitrate and chloride) whose toxicities are not expected to be altered by the addition of food. We found that the three genetically distinct clades of H. azteca had substantially different responses to starvation, and the presence/absence of food during acute toxicity tests had a strong role in determining the relative sensitivity of the three clades. In fed tests, where starvation was no longer a potential stressor, significant differences in sensitivity were still observed among the three clades. In light of these differences in sensitivity, we suggest that ecotoxicology laboratories consider using a provisional species in toxicity tests that is a regionally appropriate surrogate.

  19. Is p-tert-butylphenol-formaldehyde resin (PTBP-FR) in TRUE Test® (Mekos test) sensitizing the tested patients?

    Science.gov (United States)

    Stenberg, Berndt; Bruze, Magnus; Zimerson, Erik

    2015-12-01

    In a population study using TRUE Test®, we noted late reactions to p-tert-butylphenol-formaldehyde resin (PTBP-FR) in 0.5% of subjects tested. In order to explore possible test sensitization, differences in the contents of sensitizers within PTBP-FR in test preparations for TRUE Test® and Finn Chambers® were analysed. Subjects allergic to PTBP-FR and subjects with late reactions to PTBP-FR were retested in order to explore whether these groups reacted to different PTBP-FR sensitizers. Four individuals with late reactions and 5 subjects with established allergy to PTBP-FR were retested with defined PTBP-FR sensitizers. PTBP-FR constituents in patches from TRUE Test® were analysed with high-performance liquid chromatography. Previously analysed samples of PTBP-FR constituents served as a reference. The pattern of reaction to PTBP-FR sensitizers was similar in both groups. Subjects with suspected sensitization had somewhat stronger reactions than controls. The concentrations of monomers, dimers and trimers were generally higher in the TRUE Test® resin than in reference substances. Retesting did not add information regarding causes of possible sensitization. Analysis showed that the resin used in TRUE Test® has a lower degree of polymerization or condensation, which may enhance its sensitizing properties. A follow-up of late reactions to PTBP-FR in TRUE Test® should be carried out. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  20. New method for rapid Susceptibility Testing on blood culture with HB&L system: preliminary data

    Directory of Open Access Journals (Sweden)

    Vincenzo Rondinelli

    2010-12-01

    Full Text Available Blood culture, although represents the gold standard in detecting the ethiological agent of sepsis, is rather rarely required in relation to the real diagnostic importance. The result of this test depends in fact on many factors (sample volume, time of collection, accuracy, antibiotic therapy, contamination, number of drawings, drawing site, interpretation difficulties, etc. that are often considered by many clinicians so limited as to doubt about their actual value. The disadvantages are therefore represented by the lack of standardization but also by the low sensitivity and above all by the technical times too long for the clinical needs. Blood culture begins with the drawing of samples from the “septic” patient followed incubation of the bottles in automatic thermostated systems. In case of positive result (36 hours, the culture is Gram stained and streaked on solid media in order to obtain isolated colonies for the identification and the susceptibility testing (48 hours from positive result. The long time required for pathogen identification and susceptibility testing involves empirical broad spectrum antibiotic therapy that can promote the increase of bacterial resistance but also patient management costs. A clinically useful report should be available on short notice in order to guide the clinician to choose the most appropriate antibiotic. The microbiologist has therefore the hard work of reviewing the organization and the management of the procedures.We have therefore started to consider the possibility of treating the blood as an biological liquid in order to quickly determine the susceptibility of bacteria to antibiotics.

  1. Preliminary Benchmark Evaluation of Japan’s High Temperature Engineering Test Reactor

    Energy Technology Data Exchange (ETDEWEB)

    John Darrell Bess

    2009-05-01

    A benchmark model of the initial fully-loaded start-up core critical of Japan’s High Temperature Engineering Test Reactor (HTTR) was developed to provide data in support of ongoing validation efforts of the Very High Temperature Reactor Program using publicly available resources. The HTTR is a 30 MWt test reactor utilizing graphite moderation, helium coolant, and prismatic TRISO fuel. The benchmark was modeled using MCNP5 with various neutron cross-section libraries. An uncertainty evaluation was performed by perturbing the benchmark model and comparing the resultant eigenvalues. The calculated eigenvalues are approximately 2-3% greater than expected with an uncertainty of ±0.70%. The primary sources of uncertainty are the impurities in the core and reflector graphite. The release of additional HTTR data could effectively reduce the benchmark model uncertainties and bias. Sensitivity of the results to the graphite impurity content might imply that further evaluation of the graphite content could significantly improve calculated results. Proper characterization of graphite for future Next Generation Nuclear Power reactor designs will improve computational modeling capabilities. Current benchmarking activities include evaluation of the annular HTTR cores and assessment of the remaining start-up core physics experiments, including reactivity effects, reactivity coefficient, and reaction-rate distribution measurements. Long term benchmarking goals might include analyses of the hot zero-power critical, rise-to-power tests, and other irradiation, safety, and technical evaluations performed with the HTTR.

  2. The Dichotic Word Listening Test: preliminary observations in American and Canadian samples.

    Science.gov (United States)

    Roberts, M A; Persinger, M A; Grote, C; Evertowski, L M; Springer, J A; Tuten, T; Moulden, D; Franzen, K M; Roberts, R J; Baglio, C S

    1994-11-01

    The present article describes observations of 670 American and Canadian child and adult control subjects on the recently developed Dichotic Word Listening Test (DWLT). The task was also administered to a sample of American children with traumatic brain injuries (n=21) of varying severity and a sample of American adults with mild traumatic injuries (n=36). The conceptual focus in this line of research was on using normative observations to identify clinically defective channels of auditory processing among patients. The principal findings were as follow: 1) the DWLT was sensitive to the effects of cerebral dysfunction following traumatic brain injury; 2) differences among normal samples with different demographic backgrounds were frequently observed, arguing for the development of local norms; 3) a shorter form of the DWLT task (DWLT30) can be used for screening purposes with relatively little reduction in sensitivity to cerebral dysfunction; 4) there appeared to be considerable improvement of DWLT performance between the ages of five and seven, due largely to higher scores from the left auditory channel; and 5) there were indications that use of French (rather than English) as one's native language before age six can negatively influence performance in adulthood on an English version of the DWLT. In general, the present findings suggest that the DWLT is likely to have relatively broad applicability for neuropsychological assessment across the life-span.

  3. Results From a Pressure Sensitive Paint Test Conducted at the National Transonic Facility on Test 197: The Common Research Model

    Science.gov (United States)

    Watkins, A. Neal; Lipford, William E.; Leighty, Bradley D.; Goodman, Kyle Z.; Goad, William K.; Goad, Linda R.

    2011-01-01

    This report will serve to present results of a test of the pressure sensitive paint (PSP) technique on the Common Research Model (CRM). This test was conducted at the National Transonic Facility (NTF) at NASA Langley Research Center. PSP data was collected on several surfaces with the tunnel operating in both cryogenic mode and standard air mode. This report will also outline lessons learned from the test as well as possible approaches to challenges faced in the test that can be applied to later entries.

  4. Sensitive KIT D816V mutation analysis of blood as a diagnostic test in mastocytosis

    DEFF Research Database (Denmark)

    Kielsgaard Kristensen, Thomas; Vestergaard, Hanne; Bindslev-Jensen, Carsten;

    2014-01-01

    The recent progress in sensitive KIT D816V mutation analysis suggests that mutation analysis of peripheral blood (PB) represents a promising diagnostic test in mastocytosis. However, there is a need for systematic assessment of the analytical sensitivity and specificity of the approach in order...... the mutation in PB in nearly all adult mastocytosis patients. The mutation was detected in PB in 78 of 83 systemic mastocytosis (94%) and 3 of 4 cutaneous mastocytosis patients (75%). The test was 100% specific as determined by analysis of clinically relevant control patients who all tested negative. Mutation...

  5. In vitro skin irritation testing: Improving the sensitivity of the EpiDerm skin irritation test protocol.

    Science.gov (United States)

    Kandárová, Helena; Hayden, Patrick; Klausner, Mitch; Kubilus, Joseph; Kearney, Paul; Sheasgreen, John

    2009-12-01

    A skin irritation test (SIT) utilising a common protocol for two in vitro reconstructed human epidermal (RhE) models, EPISKIN and EpiDerm, was developed, optimised and evaluated as a replacement for the in vivo rabbit skin irritation test in an ECVAM-sponsored validation study. In 2007, both RhE models were recognised by an independent peer-review panel and the ECVAM Scientific Advisory Committee (ESAC) as validated for use with the common SIT protocol. The EPISKIN SIT was endorsed as a full replacement of the in vivo rabbit test. Since the EpiDerm SIT proved to be less sensitive than the in vivo test and the EPISKIN SIT, the test was recognised as a validated component of a tiered testing strategy, in which positive results are accepted and negative results require further confirmation. The ESAC, in its April 2007 statement, also recommended increasing the sensitivity of the EpiDerm SIT, in order to gain the full acceptance. Analysis of the EpiDerm and EPISKIN data from the ECVAM validation study indicated that the lower sensitivity of the EpiDerm SIT might be linked to the more robust barrier properties of the EpiDerm model. This hypothesis was also in line with results published previously. To overcome the relatively low sensitivity of the EpiDerm protocol as a hindrance to full regulatory acceptance, a modification of exposure conditions was introduced into the protocol to achieve better agreement with the in vivo rabbit data. In the Modified EpiDerm SIT protocol, the test chemical exposure time was increased from 15 minutes to 60 minutes. In addition, part of the exposure was performed at 37 degrees C. When the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) viability assay endpoint was used for classification, a significant increase of sensitivity was obtained (86.1%), whilst maintaining the high specificity of the method (76.3%). With the change to the EU classification system, which now uses higher cut-off for the classification of

  6. Estimation of sensitivity and specificity of five serological tests for the diagnosis of porcine brucellosis.

    Science.gov (United States)

    Praud, Anne; Gimenez, Olivier; Zanella, Gina; Dufour, Barbara; Pozzi, Nathalie; Antras, Valérie; Meyer, Laurence; Garin-Bastuji, Bruno

    2012-04-01

    While serological tests are essential in surveillance and control programs of animal diseases, to date none of the common serological tests approved in the EU (complement fixation test or Rose-Bengal test) has been shown to be reliable in routine individual diagnosis of porcine brucellosis, and some more recent tests like ELISA have not been fully evaluated yet. In the absence of a gold standard, this study allowed the estimation of sensitivities and specificities of these tests with a Bayesian approach using Markov Chain Monte Carlo algorithms. The pig population that was tested included 6422 animals from Metropolitan France. Serum samples were collected from a large population of pigs, representative of European swine population and tested with five brucellosis serological tests: Rose-Bengal test (RBT), fluorescence polarization assay (FPA), indirect ELISA (I-ELISA) and two competitive ELISAs (C-ELISA). The sensitivity and the specificity of each test were estimated. When doubtful results were excluded, the most sensitive and specific test was C-ELISA(2) (Se C-ELISA(2)=0.964, [0.907; 0.994], 95% credibility interval (CrI); Sp C-ELISA(2)=0.996, [0.982; 1.0], 95% CrI). When doubtful results were considered as negative, C-ELISA(2) was still the most sensitive and specific test (Se C-ELISA(2)=0.960, [0.896; 0.994], 95% CrI and Sp C-ELISA(2)=0.994, [0.977; 0.999], 95% CrI). The same conclusions were reached when doubtful results were considered as positive (Se C-ELISA(2)=0.963, [0.904, 0.994], 95% CrI and Sp C-ELISA(2)=0.996, [0.986; 1.0], 95% CrI).

  7. Sensitivity and specificity of rapid influenza testing of children in a community setting 1

    Science.gov (United States)

    Stebbins, Samuel; Stark, James H.; Prasad, Ramakrishna; Thompson, William W.; Mitruka, Kiren; Rinaldo, Charles; Vukotich, Charles J.; Cummings, Derek A. T.

    2010-01-01

    Please cite this paper as: Stebbins et al. (2011) Sensitivity and specificity of rapid influenza testing of children in a community setting. Influenza and Other Respiratory Viruses 5(2), 104–109. Introduction  Rapid influenza testing (RFT) allows for a rapid point‐of‐care diagnosis of influenza. The Quidel QuickVue® Influenza A+B test (QuickVue) has a reported manufacturer’s sensitivity and specificity of 73% and 96%, respectively, with nasal swabs. However, investigators have shown sensitivities ranging from 22% to 77% in community settings. Methods  The QuickVue rapid influenza test was evaluated in a population of elementary (K‐5) school children, using testing in the home, as part of the Pittsburgh Influenza Prevention Project during the 2007–2008 influenza season. The QuickVue test was performed with nasal swab in full accordance with package instructions and compared with the results of nasal swab semi‐quantitative RT‐PCR. Results  Sensitivity of the QuickVue was found to be 27% in this sample. There was no statistically valid correlation between the semi‐quantitative PCR result and the QuickVue result. Conclusions  This study is consistent with the low sensitivity of the QuickVue test also reported by others. Viral load, technique, and the use of nasal swabs were examined as contributing factors but were not found to be explanations for this result. Community testing includes patients who are on the lower spectrum of illness which would not be the case in hospital or clinic samples. This suggests that RFT is less sensitive for patients at the lower spectrum of illness, with less severe disease. PMID:21306573

  8. Long-term repeatability of the skin prick test is high when supported by history or allergen-sensitivity tests

    DEFF Research Database (Denmark)

    Bødtger, Uffe; Jacobsen, C R; Poulsen, L K;

    2003-01-01

    BACKGROUND: Long-term reproducibility of the skin-prick test (SPT) has been questioned. The aim of the study was to investigate the clinical relevance of SPT changes. METHODS: SPT to 10 common inhalation allergens was performed annually from 1999 to 2001 in 25 nonsensitized and 21 sensitized...

  9. Comparison of sensitivity of QuantiFERON-TB gold test and tuberculin skin test in active pulmonary tuberculosis.

    Science.gov (United States)

    Khalil, Kanwal Fatima; Ambreen, Asma; Butt, Tariq

    2013-09-01

    To compare the sensitivity of tuberculin skin test (TST) and quantiFERON-TB gold test (QFT-G) in active pulmonary tuberculosis. Analytical study. Department of Pulmonology, Fauji Foundation Hospital, Rawalpindi, from July 2011 to January 2012. QuantiFERON-TB gold test (QFT-G) was evaluated and compared it with tuberculin skin test (TST) in 50 cases of active pulmonary tuberculosis, in whom tuberculous infection was suspected on clinical, radiological and microbiological grounds. Sensitivity was determined against postive growth for Mycobacterium tuberculosis. Out of 50 cases, 43 were females and 7 were males. The mean age was 41.84 ± 19.03 years. Sensitivity of QFT-G was 80% while that of TST was 28%. QFT-G has much higher sensitivity than TST for active pulmonary tuberculosis. It is unaffected by prior BCG administration and prior exposure to atypical mycobacteria. A positive QFT-G result can be an adjunct to diagnosis in patients having clinical and radiological data compatible with pulmonary tuberculosis.

  10. Central sensitization phenomena after third molar surgery: A quantitative sensory testing study

    DEFF Research Database (Denmark)

    Juhl, Gitte Irene; Jensen, Troels Staehelin; Nørholt, Svend Erik;

    2008-01-01

    impacted third molar. RESULTS: Central sensitization for at least one week was indicated by significantly increased pain intensity evoked by intraoral repetitive pinprick and electrical stimulation (p...BACKGROUND: Surgical removal of third molars may carry a risk of developing persistent orofacial pain, and central sensitization appears to play an important role in the transition from acute to chronic pain. AIM: The aim of this study was to investigate sensitization (primarily central...... sensitization) after orofacial trauma using quantitative sensory testing (QST). METHODS: A total of 32 healthy men (16 patients and 16 age-matched control subjects) underwent a battery of quantitative tests adapted to the trigeminal area at baseline and 2, 7, and 30 days following surgical removal of a lower...

  11. A Structured Clinical Interview for Kleptomania (SCI-K): preliminary validity and reliability testing.

    Science.gov (United States)

    Grant, Jon E; Kim, Suck Won; McCabe, James S

    2006-06-01

    Kleptomania presents difficulties in diagnosis for clinicians. This study aimed to develop and test a DSM-IV-based diagnostic instrument for kleptomania. To assess for current kleptomania the Structured Clinical Interview for Kleptomania (SCI-K) was administered to 112 consecutive subjects requesting psychiatric outpatient treatment for a variety of disorders. Reliability and validity were determined. Classification accuracy was examined using the longitudinal course of illness. The SCI-K demonstrated excellent test-retest (Phi coefficient = 0.956 (95% CI = 0.937, 0.970)) and inter-rater reliability (phi coefficient = 0.718 (95% CI = 0.506, 0.848)) in the diagnosis of kleptomania. Concurrent validity was observed with a self-report measure using DSM-IV kleptomania criteria (phi coefficient = 0.769 (95% CI = 0.653, 0.850)). Discriminant validity was observed with a measure of depression (point biserial coefficient = -0.020 (95% CI = -0.205, 0.166)). The SCI-K demonstrated both high sensitivity and specificity based on longitudinal assessment. The SCI-K demonstrated excellent reliability and validity in diagnosing kleptomania in subjects presenting with various psychiatric problems. These findings require replication in larger groups, including non-psychiatric populations, to examine their generalizability. Copyright (c) 2006 John Wiley & Sons, Ltd.

  12. Two-step sensitivity testing of parametrized and regionalized life cycle assessments: methodology and case study.

    Science.gov (United States)

    Mutel, Christopher L; de Baan, Laura; Hellweg, Stefanie

    2013-06-04

    Comprehensive sensitivity analysis is a significant tool to interpret and improve life cycle assessment (LCA) models, but is rarely performed. Sensitivity analysis will increase in importance as inventory databases become regionalized, increasing the number of system parameters, and parametrized, adding complexity through variables and nonlinear formulas. We propose and implement a new two-step approach to sensitivity analysis. First, we identify parameters with high global sensitivities for further examination and analysis with a screening step, the method of elementary effects. Second, the more computationally intensive contribution to variance test is used to quantify the relative importance of these parameters. The two-step sensitivity test is illustrated on a regionalized, nonlinear case study of the biodiversity impacts from land use of cocoa production, including a worldwide cocoa products trade model. Our simplified trade model can be used for transformable commodities where one is assessing market shares that vary over time. In the case study, the highly uncertain characterization factors for the Ivory Coast and Ghana contributed more than 50% of variance for almost all countries and years examined. The two-step sensitivity test allows for the interpretation, understanding, and improvement of large, complex, and nonlinear LCA systems.

  13. Preliminary Results from Second Phase Sea Testing of the Wave Dragon Prototype Wave Energy Converter

    DEFF Research Database (Denmark)

    Soerensen, Hans Chr.; Tedd, James; Friis-Madsen, Erik;

    2006-01-01

    In March 2006 the prototype Wave Dragon has been redeployed to a more energetic site in Nissum Bredning an inland sea in Western Denmark. This has followed a period of renovation of many aspects of the device which have resulted in 20% higher energy output. This paper describes the preliminary re...

  14. Preliminary Results from Second Phase Sea Testing of the Wave Dragon Prototype Wave Energy Converter

    DEFF Research Database (Denmark)

    Soerensen, Hans Chr.; Tedd, James; Friis-Madsen, Erik

    2006-01-01

    In March 2006 the prototype Wave Dragon has been redeployed to a more energetic site in Nissum Bredning an inland sea in Western Denmark. This has followed a period of renovation of many aspects of the device which have resulted in 20% higher energy output. This paper describes the preliminary...

  15. Preliminary studies of tunnel interface response modeling using test data from underground storage facilities.

    Energy Technology Data Exchange (ETDEWEB)

    Sobolik, Steven Ronald; Bartel, Lewis Clark

    2010-11-01

    correctly image the tunnel. This report represents a preliminary step in the development of a methodology to convert numerical predictions of rock properties to an estimation of the extent of rock damage around an underground facility and its corresponding seismic velocity, and the corresponding application to design a testing methodology for tunnel detection.

  16. PRELIMINARY FRIT DEVELOPMENT AND MELT RATE TESTING FOR SLUDGE BATCH 6 (SB6)

    Energy Technology Data Exchange (ETDEWEB)

    Fox, K.; Miller, D.; Edwards, T.

    2009-07-21

    The Liquid Waste Organization (LWO) provided the Savannah River National Laboratory (SRNL) with a Sludge Batch 6 (SB6) composition projection in March 2009. Based on this projection, frit development efforts were undertaken to gain insight into compositional effects on the predicted and measured properties of the glass waste form and to gain insight into frit components that may lead to improved melt rate for SB6-like compositions. A series of Sludge Batch 6 (SB6) based glasses was selected, fabricated and characterized in this study to better understand the ability of frit compositions to accommodate uncertainty in the projected SB6 composition. Acceptable glasses (compositions where the Product Composition Control System (PCCS) Measurement Acceptability Region (MAR) predicted acceptable properties, good chemical durability was measured, and no detrimental nepheline crystallization was observed) can be made using Frit 418 with SB6 over a range of Na{sub 2}O and Al{sub 2}O{sub 3} concentrations. However, the ability to accommodate variation in the sludge composition limits the ability to utilize alternative frits for potential improvements in melt rate. Frit 535, which may offer improvements in melt rate due to its increased B2O3 concentration, produced acceptable glasses with the baseline SB6 composition at waste loadings of 34 and 42%. However, the PCCS MAR results showed that it is not as robust as Frit 418 in accommodating variation in the sludge composition. Preliminary melt rate testing was completed in the Melt Rate Furnace (MRF) with four candidate frits for SB6. These four frits were selected to evaluate the impacts of B{sub 2}O{sub 3} and Na{sub 2}O concentrations in the frit relative to those of Frit 418, although they are not necessarily candidates for SB6 vitrification. Higher concentrations of B{sub 2}O{sub 3} in the frit relative to that of Frit 418 appeared to improve melt rate. However, when a higher concentration of B{sub 2}O{sub 3} was coupled

  17. A Simple in-vitro Test for Assessing the Sensitivity of Lymphocytes to Chlorambucil

    Science.gov (United States)

    Lawler, Sylvia D.; Lele, Kusum P.; Pentycross, C. R.

    1971-01-01

    The sensitivity of lymphocytes to chlorambucil has been assessed by a simple in-vitro test which has been applied to the cells of normal controls and of patients with chronic lymphocytic leukaemia. The degree of sensitivity varied amongst the normal controls and in-vitro resistance of the lymphocytes in the patients was sometimes found in the absence of in-vivo experience of the drug. Resistance in-vitro tended to be associated with very high total peripheral blood lymphocyte counts but not with the age of the patient. Where the information was available the in-vitro sensitivity test agreed with the results of biochemical estimations of drug resistance and with the clinical responses to the drug. It is suggested that this test may have applications in patient management. PMID:5144524

  18. A Rapid In-Clinic Test Detects Acute Leptospirosis in Dogs with High Sensitivity and Specificity.

    Science.gov (United States)

    Kodjo, Angeli; Calleja, Christophe; Loenser, Michael; Lin, Dan; Lizer, Joshua

    2016-01-01

    A rapid IgM-detection immunochromatographic test (WITNESS® Lepto, Zoetis) has recently become available to identify acute canine leptospirosis at the point of care. Diagnostic sensitivity and specificity of the test were evaluated by comparison with the microscopic agglutination assay (MAT), using a positive cut-off titer of ≥800. Banked serum samples from dogs exhibiting clinical signs and suspected leptospirosis were selected to form three groups based on MAT titer: (1) positive (n = 50); (2) borderline (n = 35); and (3) negative (n = 50). Using an analysis to weight group sizes to reflect French prevalence, the sensitivity and specificity were 98% and 93.5% (88.2% unweighted), respectively. This test rapidly identifies cases of acute canine leptospirosis with high levels of sensitivity and specificity with no interference from previous vaccination.

  19. Screening Test for Detection of Leptinotarsa decemlineata (Say Sensitivity to Insecticides

    Directory of Open Access Journals (Sweden)

    Dušanka Inđić

    2012-01-01

    Full Text Available In 2009, the sensitivity of 15 field populations of Colorado potato beetle (Leptinotarsadecemlineata Say. - CPB was assessed to chlorpyrifos, cypermethrin, thiamethoxam and fipronil,four insecticides which are mostly used for its control in Serbia. Screening test that allows rapidassessment of sensitivity of overwintered adults to insecticides was performed. Insecticideswere applied at label rates, and two, five and 10 fold higher rates by soaking method (5 sec.Mortality was assessed after 72h. From 15 monitored populations of CPB, two were sensitiveto label rate of chlorpyrifos, one was slightly resistant, 11 were resistant and one populationwas highly resistant. Concerning cypermethrin, two populations were sensitive, two slightlyresistant, five were resistant and six highly resistant. Highly sensitive to thiamethoxam labelrate were 12 populations, while three were sensitive. In the case of fipronil applied at label rate,two populations were highly sensitive, six sensitive, one slightly resistant and six were resistant.The application of insecticides at higher rates (2, 5 and 10 fold, that is justified only in bioassays,provided a rapid insight into sensitivity of field populations of CPB to insecticides.

  20. New lab-made coagulant based on Schinopsis balansae tannin extract: synthesis optimization and preliminary tests on refractory water pollutants

    Science.gov (United States)

    Sánchez-Martín, J.; Beltrán-Heredia, J.; Coco-Rivero, B.

    2014-09-01

    Quebracho colorado tannin extract was used as a coagulant raw material for water and wastewater treatment. The chemical synthesis follows a Mannich reaction mechanism and provides a fully working coagulant that can remove several pollutants from water. This paper addresses the optimization of such synthesis and confirms the feasibility of the coagulant by testing it in a preliminary screening for the elimination of dyes and detergents. The optimum combination of reagents was 6.81 g of diethanolamine (DEA) and 2.78 g of formaldehyde (F) per g of tannin extract. So obtained coagulant was succesfully tested on the removal of 9 dyes and 8 detergents.

  1. Evaluating the sensitivity and predictive value of tests of recent infection: toxoplasmosis in pregnancy.

    Science.gov (United States)

    Ades, A E

    1991-12-01

    The diagnosis of maternal infection in early pregnancy depends on tests which are sensitive to recent infection, such as specific IgM. Two types of test are considered: those where the response persists for a period following infection and then declines, such as IgM, and those whose response increases with time since infection, such as IgG-avidity. However, individuals vary in their response to infection, and it may not always be possible to determine whether an infection occurred during pregnancy or before it. Mathematical methods are developed to evaluate the performance of these tests, and are applied to the diagnosis of toxoplasmosis in pregnancy. It is shown that, based on existing information, tests of recent infection are unlikely to be both sensitive and predictive. More data on these tests are required, before they can be reliably used to determine whether infection has occurred during pregnancy or before it.

  2. Age sensitivity of behavioral tests and brain substrates of normal aging in mice.

    Science.gov (United States)

    Kennard, John A; Woodruff-Pak, Diana S

    2011-01-01

    Knowledge of age sensitivity, the capacity of a behavioral test to reliably detect age-related changes, has utility in the design of experiments to elucidate processes of normal aging. We review the application of these tests in studies of normal aging and compare and contrast the age sensitivity of the Barnes maze, eyeblink classical conditioning, fear conditioning, Morris water maze, and rotorod. These tests have all been implemented to assess normal age-related changes in learning and memory in rodents, which generalize in many cases to age-related changes in learning and memory in all mammals, including humans. Behavioral assessments are a valuable means to measure functional outcomes of neuroscientific studies of aging. Highlighted in this review are the attributes and limitations of these measures in mice in the context of age sensitivity and processes of brain aging. Attributes of these tests include reliability and validity as assessments of learning and memory, well-defined neural substrates, and sensitivity to neural and pharmacological manipulations and disruptions. These tests engage the hippocampus and/or the cerebellum, two structures centrally involved in learning and memory that undergo functional and anatomical changes in normal aging. A test that is less well represented in studies of normal aging, the context pre-exposure facilitation effect (CPFE) in fear conditioning, is described as a method to increase sensitivity of contextual fear conditioning to changes in the hippocampus. Recommendations for increasing the age sensitivity of all measures of normal aging in mice are included, as well as a discussion of the potential of the under-studied CPFE to advance understanding of subtle hippocampus-mediated phenomena.

  3. Age Sensitivity of Behavioral Tests and Brain Substrates of Normal Aging in Mice

    Directory of Open Access Journals (Sweden)

    John A. Kennard

    2011-05-01

    Full Text Available Knowledge of age sensitivity, the capacity of a behavioral test to reliably detect age-related changes, has utility in the design of experiments to elucidate processes of normal aging. We review the application of these tests in studies of normal aging and compare and contrast the age sensitivity of the Barnes maze, eyeblink classical conditioning, fear conditioning, Morris water maze and rotorod. These tests have all been implemented to assess normal age-related changes in learning and memory in rodents, which generalize in many cases to age-related changes in learning and memory in all mammals, including humans. Behavioral assessments are a valuable means to measure functional outcomes of neuroscientific studies of aging. Highlighted in this review are the attributes and limitations of these measures in mice in the context of age sensitivity and processes of brain aging. Attributes of these tests include reliability and validity as assessments of learning and memory, well-defined neural substrates, and sensitivity to neural and pharmacological manipulations and disruptions. These tests engage the hippocampus and/or the cerebellum, two structures centrally involved in learning and memory that undergo functional and anatomical changes in normal aging. A test that is less well represented in studies of normal aging, the context pre-exposure facilitation effect (CPFE in fear conditioning, is described as a method to increase sensitivity of contextual fear conditioning to changes in the hippocampus. Recommendations for increasing the age sensitivity of all measures of normal aging in mice are included, as well as a discussion of the potential of the under-studied CPFE to advance understanding of subtle hippocampus-mediated phenomena.

  4. The CAST (Childhood Asperger Syndrome Test): preliminary development of a UK screen for mainstream primary-school-age children.

    Science.gov (United States)

    Scott, Fiona J; Baron-Cohen, Simon; Bolton, Patrick; Brayne, Carol

    2002-03-01

    The article describes a pilot and follow-up study of the preliminary development of a new tool to screen for Asperger syndrome (AS) and related social and communication conditions (the Childhood Asperger Syndrome Test, CAST) in children aged 4-11 years, in a non-clinical setting. In the pilot study, parents of 13 children with AS and of 37 typically developing children completed the CAST. There were significant differences between the AS and typical sample means. The pilot was used to establish preliminary cut-off scores for the CAST. In the main study, parents of 1150 primary-school-age children were sent the CAST, and 174 took part in the full data analysis. Results suggest that compared with other tools currently available, the CAST may be useful for identifying children at risk for AS and related conditions, in a mainstream non-clinical sample. Further research is ongoing.

  5. A new framework for the interpretation of IgE sensitization tests

    DEFF Research Database (Denmark)

    Roberts, G; Ollert, M; Aalberse, R.;

    2016-01-01

    IgE sensitization tests, such as skin prick testing and serum-specific IgE, have been used to diagnose IgE-mediated clinical allergy for many years. Their prime drawback is that they detect sensitization which is only loosely related to clinical allergy. Many patients therefore require provocation...... pretest probabilities for diverse setting, regions and allergens. Also, cofactors, such as exercise, may be necessary for exposure to an allergen to result in an allergic reaction in specific IgE-positive patients. The diagnosis of IgE-mediated allergy is now being aided by the introduction of allergen...

  6. Use of genotoxicity information in the development of integrated testing strategies (ITS) for skin sensitization.

    Science.gov (United States)

    Mekenyan, Ovanes; Patlewicz, Grace; Dimitrova, Gergana; Kuseva, Chanita; Todorov, Milen; Stoeva, Stoyanka; Kotov, Stefan; Donner, E Maria

    2010-10-18

    Skin sensitization is an end point of concern for various legislation in the EU, including the seventh Amendment to the Cosmetics Directive and Registration Evaluation, Authorisation and Restriction of Chemicals (REACH). Since animal testing is a last resort for REACH or banned (from 2013 onward) for the Cosmetics Directive, the use of intelligent/integrated testing strategies (ITS) as an efficient means of gathering necessary information from alternative sources (e.g., in vitro, (Q)SARs, etc.) is gaining widespread interest. Previous studies have explored correlations between mutagenicity data and skin sensitization data as a means of exploiting information from surrogate end points. The work here compares the underlying chemical mechanisms for mutagenicity and skin sensitization in an effort to evaluate the role mutagenicity information can play as a predictor of skin sensitization potential. The Tissue Metabolism Simulator (TIMES) hybrid expert system was used to compare chemical mechanisms of both end points since it houses a comprehensive set of established structure-activity relationships for both skin sensitization and mutagenicity. The evaluation demonstrated that there is a great deal of overlap between skin sensitization and mutagenicity structural alerts and their underlying chemical mechanisms. The similarities and differences in chemical mechanisms are discussed in light of available experimental data. A number of new alerts for mutagenicity were also postulated for inclusion into TIMES. The results presented show that mutagenicity information can provide useful insights on skin sensitization potential as part of an ITS and should be considered prior to any in vivo skin sensitization testing being initiated.

  7. Preliminary Feasibility, Design, and Hazard Analysis of a Boiling Water Test Loop Within the Idaho National Laboratory Advanced Test Reactor National Scientific User Facility

    Energy Technology Data Exchange (ETDEWEB)

    Douglas M. Gerstner

    2009-05-01

    The Advanced Test Reactor (ATR) is a pressurized light-water reactor with a design thermal power of 250 MW. The principal function of the ATR is to provide a high neutron flux for testing reactor fuels and other materials. The ATR and its support facilities are located at the Idaho National Laboratory (INL). A Boiling Water Test Loop (BWTL) is being designed for one of the irradiation test positions within the. The objective of the new loop will be to simulate boiling water reactor (BWR) conditions to support clad corrosion and related reactor material testing. Further it will accommodate power ramping tests of candidate high burn-up fuels and fuel pins/rods for the commercial BWR utilities. The BWTL will be much like the pressurized water loops already in service in 5 of the 9 “flux traps” (region of enhanced neutron flux) in the ATR. The loop coolant will be isolated from the primary coolant system so that the loop’s temperature, pressure, flow rate, and water chemistry can be independently controlled. This paper presents the proposed general design of the in-core and auxiliary BWTL systems; the preliminary results of the neutronics and thermal hydraulics analyses; and the preliminary hazard analysis for safe normal and transient BWTL and ATR operation.

  8. Respiratory panic disorder subtype and sensitivity to the carbon dioxide challenge test

    Directory of Open Access Journals (Sweden)

    Valença A.M.

    2002-01-01

    Full Text Available The aim of the present study was to verify the sensitivity to the carbon dioxide (CO2 challenge test of panic disorder (PD patients with respiratory and nonrespiratory subtypes of the disorder. Our hypothesis is that the respiratory subtype is more sensitive to 35% CO2. Twenty-seven PD subjects with or without agoraphobia were classified into respiratory and nonrespiratory subtypes on the basis of the presence of respiratory symptoms during their panic attacks. The tests were carried out in a double-blind manner using two mixtures: 1 35% CO2 and 65% O2, and 2 100% atmospheric compressed air, 20 min apart. The tests were repeated after 2 weeks during which the participants in the study did not receive any psychotropic drugs. At least 15 of 16 (93.7% respiratory PD subtype patients and 5 of 11 (43.4% nonrespiratory PD patients had a panic attack during one of two CO2 challenges (P = 0.009, Fisher exact test. Respiratory PD subtype patients were more sensitive to the CO2 challenge test. There was agreement between the severity of PD measured by the Clinical Global Impression (CGI Scale and the subtype of PD. Higher CGI scores in the respiratory PD subtype could reflect a greater sensitivity to the CO2 challenge due to a greater severity of PD. Carbon dioxide challenges in PD may define PD subtypes and their underlying mechanisms.

  9. Sensitivity and specificity of parallel or serial serological testing for detection of canine Leishmania infection

    Directory of Open Access Journals (Sweden)

    Mauro Maciel de Arruda

    2016-01-01

    Full Text Available In Brazil, human and canine visceral leishmaniasis (CVL caused byLeishmania infantum has undergone urbanisation since 1980, constituting a public health problem, and serological tests are tools of choice for identifying infected dogs. Until recently, the Brazilian zoonoses control program recommended enzyme-linked immunosorbent assays (ELISA and indirect immunofluorescence assays (IFA as the screening and confirmatory methods, respectively, for the detection of canine infection. The purpose of this study was to estimate the accuracy of ELISA and IFA in parallel or serial combinations. The reference standard comprised the results of direct visualisation of parasites in histological sections, immunohistochemical test, or isolation of the parasite in culture. Samples from 98 cases and 1,327 noncases were included. Individually, both tests presented sensitivity of 91.8% and 90.8%, and specificity of 83.4 and 53.4%, for the ELISA and IFA, respectively. When tests were used in parallel combination, sensitivity attained 99.2%, while specificity dropped to 44.8%. When used in serial combination (ELISA followed by IFA, decreased sensitivity (83.3% and increased specificity (92.5% were observed. Serial testing approach improved specificity with moderate loss in sensitivity. This strategy could partially fulfill the needs of public health and dog owners for a more accurate diagnosis of CVL.

  10. Factors influencing antibiotic prescribing habits and use of sensitivity testing amongst veterinarians in Europe

    Science.gov (United States)

    De Briyne, N.; Atkinson, J.; Pokludová, L.; Borriello, S. P.; Price, S.

    2013-01-01

    The Heads of Medicines Agencies and the Federation of Veterinarians of Europe undertook a survey to gain a better insight into the decision-making process of veterinarians in Europe when deciding which antibiotics to prescribe. The survey was completed by 3004 practitioners from 25 European countries. Analysis was to the level of different types of practitioner (food producing (FP) animals, companion animals, equines) and country for Belgium, Czech Republic, France, Germany, Spain, Sweden and the UK. Responses indicate no single information source is universally considered critical, though training, published literature and experience were the most important. Factors recorded which most strongly influenced prescribing behaviour were sensitivity tests, own experience, the risk for antibiotic resistance developing and ease of administration. Most practitioners usually take into account responsible use warnings. Antibiotic sensitivity testing is usually performed where a treatment failure has occurred. Significant differences were observed in the frequency of sensitivity testing at the level of types of practitioners and country. The responses indicate a need to improve sensitivity tests and services, with the availability of rapid and cheaper testing being key factors. PMID:24068699

  11. Consistency and construction in stated WTP for health risk reductions: A novel scope-sensitivity test

    Energy Technology Data Exchange (ETDEWEB)

    Bateman, Ian J. [Centre for Social and Economic Research on the Global Environment (CSERGE), School of Environmental Sciences, University of East Anglia, Norwich NR4 7TJ (United Kingdom); Brouwer, Roy [Institute for Environmental Studies (IVM), Vrije Universiteit, De Boelelaan 1087, 1081 HV Amsterdam (Netherlands)

    2006-08-15

    A contingent valuation study is conducted to estimate willingness to pay (WTP) for reducing skin cancer risks. A split sample design contrasts dichotomous choice (DC) with open-ended (OE) methods for eliciting WTP. A novel scope test varies the remit of risk reductions from just the individual respondent to their entire household allowing us to examine both the statistical significance and scale of scope sensitivity. While OE responses fail such tests, DC responses pass both forms of testing. We conclude that conformity of the size of scope effects with prior expectations should form a focus for future validity testing. (author)

  12. Sensitivity of Occupant Response Subject to Prescribed Corridors for Impact Testing

    Directory of Open Access Journals (Sweden)

    J.R. Crandall

    1996-01-01

    Full Text Available A technology to study the sensitivity of impact responses to prescribed test conditions is presented. Motor vehicle impacts are used to illustrate the principles of this sensitivity technology. Impact conditions are regulated by specifying either a corridor for the acceleration time history or other test parameters such as velocity change, static crush distance, and pulse duration. By combining a time domain constrained optimization method and a multirigid body dynamics simulator, the upper and lower bounds of occupant responses subject to the regulated corridors were obtained. It was found that these prescribed corridors may be either so wide as to allow extreme variations in occupant response or so narrow that they are physically unrealizable in the laboratory test environment. A new corridor based on specifications for the test parameters of acceleration, velocity. crush distance, and duration for frontal vehicle impacts is given.

  13. Nuclear maintenance strategy and first steps for preliminary maintenance plan of the EU HCLL & HCPB Test Blanket Systems

    Energy Technology Data Exchange (ETDEWEB)

    Galabert, Jose, E-mail: jose.galabert@f4e.europa.eu [F4E Fusion for Energy, EU Domestic Agency, c/Josep Pla, 2. B3, 08019, Barcelona (Spain); Hopper, Dave [AMEC Foster Wheeler, Faraday Street, Birchwood Park, WA3 6GN (United Kingdom); Neviere, Jean-Cristophe [ITER Organization, Route de Vinon-sur-Verdon, CS 90046, 13067, St. Paul Lez Durance Cedex (France); Nodwell, David [CCFE, Culham Science Centre, Abingdon, OX14 3DB, Oxfordshire (United Kingdom); Pascal, Romain [ITER Organization, Route de Vinon-sur-Verdon, CS 90046, 13067, St. Paul Lez Durance Cedex (France); Poitevin, Yves; Ricapito, Italo [F4E Fusion for Energy, EU Domestic Agency, c/Josep Pla, 2. B3, 08019, Barcelona (Spain); White, Gareth [AMEC Foster Wheeler, Faraday Street, Birchwood Park, WA3 6GN (United Kingdom)

    2017-03-15

    Highlights: • Nuclear maintenance strategy for the two European (EU) Test Blanket Systems (TBS): i/. Helium Cooled Lead Lithium (HCLL) and ii/. Helium Cooled Pebble Bed (HCPB). • Preliminary identification of maintenance tasks for most relevant components of the EU HCLL & HCPB TBS. • Preliminary feasibility analysis for hands-on maintenance tasks of some relevant components of the European Test Blanket Systems. • Design recommendations for enhancement of the European Test Blanket Systems maintainability. - Abstract: This paper gives an overview of nuclear maintenance strategy to be followed for the European HCLL & HCPB Test Blanket Systems (TBS) to be installed in ITER. One of the several core documents to prepare in view of their licensing is their respective ‘Maintenance Plan’. This document is fundamental for ensuring sound performance and safety of the TBS during ITER’s operational phase and shall include, amongst others, relevant information on: maintenance organization, preventive and corrective maintenance task procedures, condition monitoring for key components, maintenance work planning, and a spare parts plan, just to mention some of the key topics. In compliance with the ITER Plant Maintenance policy, first steps have been taken aimed at defining nuclear maintenance strategy for some of the most relevant HCLL & HCPB TBS components, conducted by F4E in collaboration with industry. After a brief recall of maintenance strategy of the TBM Program (PBS-56), this paper analyses main features of EU HCLL & HCPB TBS maintainability and identifies, at their conceptual design phase, a preliminary list of maintenance tasks to be developed for their most representative components. In addition, the paper also presents the first nuclear maintenance studies conducted for replacement of the Q{sub 2} Getter Beds, identifying some design recommendations for their sound maintainability.

  14. Evaluation of the sensitivity of freshwater organisms used in toxicity tests of wastewater from explosives company.

    Science.gov (United States)

    Ribeiro, Elaine Nolasco; da Silva, Flávio Teixeira; de Paiva, Teresa Cristina Brazil

    2012-10-01

    Explosives industries are a source of toxic discharge. The aim of this study was to compare organisms sensitivity (Daphnia similis, Danio rerio, Escherichia coli and Pseudomonas putida) in detecting acute toxicity in wastewater from two explosives, 2,4,6-TNT (TNT) and nitrocellulose. The samples were collected from an explosives company in the Paraiba Valley, São Paulo, Brazil. The effluents from TNT and nitrocellulose production were very toxic for tested organisms. Statistical tests indicated that D. similis and D. rerio were the most sensitive organisms for toxicity detection in effluents from 2,4,6-TNT and nitrocellulose production. The P. putida bacteria was the organism considered the least sensitive in indicating toxicity in effluents from nitrocellulose.

  15. Moisture sensitivity examination of asphalt mixtures using thermodynamic, direct adhesion peel and compacted mixture mechanical tests

    OpenAIRE

    Zhang, Jizhe; AIREY, Gordon D; Grenfell, James; Apeagyei, Alex K.

    2016-01-01

    Moisture damage in asphalt mixtures is a complicated mode of pavement distress that results in the loss of stiffness and structural strength of the asphalt pavement layers. This paper evaluated the moisture sensitivity of different aggregate–bitumen combinations through three different approaches: surface energy, peel adhesion and the Saturation Ageing Tensile Stiffness (SATS) tests. In addition, the results obtained from these three tests were compared so as to characterise the relationship ...

  16. Preliminary tests for Salix sp. tolerance to heavy metals (Cd, Ni, Pb)

    Science.gov (United States)

    Corneanu, Mihaela; Hernea, Cornelia; Butnariu, Monica; Corneanu, Gabriel; Sărac, Ioan; Hollerbach, Wilhelm; Neţoiu, Constantin; Petcov, Andreea Adriana

    2014-05-01

    The species of Salix genus constitute potential sources of germplasm in the prevention of the environment degradation, and offer remedy for about two third from the all degradation types. The majority of the willow species, present a good adaptation to hypoxic conditions, feature which suggest that they manifest a preference for mineral nutrition in comparison with organic one. Thus, many of willow species can be developed on soils with a big amount of minerals and/or radionuclides, being both phytoremediatory species, as well as pioneer ones, contributing to the restoration of soil. Thus, the willow species, posses the capacity for development in degraded areas, natural or anthropic, as swamps, abandoning crops areas, sandy dune, riparian sandy areas, gravels, a.o. In this paper are present some laboratory comparative tests of heavy metals tolerance on four Salix sp. genotypes: clone 202 (Salix alba), hybrid 892 (Salix alba), Inger (Salix viminalis) and Gudrun (Salix viminalis). The genotypes of Salix alba are native from Romania, produced in the Forest Research and Management Institute Bucharest, while the genotypes of Salix viminalis are native from Sweden, but the plant material was produced under license in Romania by REBINA Agrar SRL. As plant material were used one-year-old cuttings (5-10 cm long), with 2-6 buds each. Per genotype, per heavy metal and each of three concentration five replication were used. There were ten experimental variants for each genotype: three concentrations for each of the heavy metals; concentrations selected, in the accordance SR ISO 11269-2/March 1999 and Control (tap water). The cuttings were maintained in metalic solutions for 15 days. In the days 7th and 15th, were performed biometrical observations on: the roots number and length, the shoots number and length, the leaves number/shoot, viability of the shoots. At the end of the experiment the content in heavy metals was determined in roots and shoots (by atomic absorption

  17. Rapid, high sensitivity, point-of-care test for cardiac troponin based on optomagnetic biosensor

    NARCIS (Netherlands)

    Dittmer, W.U.; Evers, T.H.; Hardeman, W.M.; Huijnen-Keur, W.M.; Kamps, R.; De Kievit, P.; Neijzen, J.H.M.; Sijbers, M.J.J.; Nieuwenhuis, J.H.; Hefti, M.H.; Dekkers, D.; Martens, M.

    2010-01-01

    BACKGROUND: We present a handheld integrated device based on a novel magnetic-optical technology for the sensitive detection of cardiactroponin I, a biomarker for the positive diagnosis of myocardial infarct, in a finger-prick blood sample. The test can be performed with a turn-around time of 5 min

  18. Application of Unidimensional Item Response Models to Tests with Items Sensitive to Secondary Dimensions

    Science.gov (United States)

    Zhang, Bo

    2008-01-01

    In this research, the author addresses whether the application of unidimensional item response models provides valid interpretation of test results when administering items sensitive to multiple latent dimensions. Overall, the present study found that unidimensional models are quite robust to the violation of the unidimensionality assumption due…

  19. Insecticide species sensitivity distributions: importance of test species selection and relevance to aquatic ecosystems

    NARCIS (Netherlands)

    Maltby, L.; Blake, N.; Brock, T.C.M.; Brink, van den P.J.

    2005-01-01

    Single-species acute toxicity data and (micro)mesocosm data were collated for 16 insecticides. These data were used to investigate the importance of test-species selection in constructing species sensitivity distributions (SSDs) and the ability of estimated hazardous concentrations (HCs) to protect

  20. Effect of training intensity on insulin sensitivity evaluated by insulin tolerance test

    NARCIS (Netherlands)

    K. Backx; H.A. Keizer; M.F. Mensink; dr. Lars B. Borghouts

    1999-01-01

    This research article shows that a high intensity exercise program compared to a low intensity exercise program of the same session duration and frequency, increases insulin sensitivity to a larger extend in healthy subjects. It also shows that the short insulin tolerance test can be used to detect

  1. Fish-Friendly Hydropower Turbine Development & Deployment: Alden Turbine Preliminary Engineering and Model Testing

    Energy Technology Data Exchange (ETDEWEB)

    Foust, J. [Voith Hydro, Inc., York, PA (USA); Hecker, G. [Alden Research Laboratory, Inc., Holden, MA (USA); Li, S. [Alden Research Laboratory, Inc., Holden, MA (USA); Allen, G. [Alden Research Laboratory, Inc., Holden, MA (USA)

    2011-10-01

    The Alden turbine was developed through the U.S. Department of Energy's (DOE's) former Advanced Hydro Turbine Systems Program (1994-2006) and, more recently, through the Electric Power Research Institute (EPRI) and the DOE's Wind & Water Power Program. The primary goal of the engineering study described here was to provide a commercially competitive turbine design that would yield fish passage survival rates comparable to or better than the survival rates of bypassing or spilling flow. Although the turbine design was performed for site conditions corresponding to 92 ft (28 m) net head and a discharge of 1500 cfs (42.5 cms), the design can be modified for additional sites with differing operating conditions. During the turbine development, design modifications were identified for the spiral case, distributor (stay vanes and wicket gates), runner, and draft tube to improve turbine performance while maintaining features for high fish passage survival. Computational results for pressure change rates and shear within the runner passage were similar in the original and final turbine geometries, while predicted minimum pressures were higher for the final turbine. The final turbine geometry and resulting flow environments are expected to further enhance the fish passage characteristics of the turbine. Computational results for the final design were shown to improve turbine efficiencies by over 6% at the selected operating condition when compared to the original concept. Prior to the release of the hydraulic components for model fabrication, finite element analysis calculations were conducted for the stay vanes, wicket gates, and runner to verify that structural design criteria for stress and deflections were met. A physical model of the turbine was manufactured and tested with data collected for power and efficiency, cavitation limits, runaway speed, axial and radial thrust, pressure pulsations, and wicket gate torque. All parameters were observed to fall

  2. Identification of precision treatment strategies for relapsed/refractory multiple myeloma by functional drug sensitivity testing.

    Science.gov (United States)

    Majumder, Muntasir Mamun; Silvennoinen, Raija; Anttila, Pekka; Tamborero, David; Eldfors, Samuli; Yadav, Bhagwan; Karjalainen, Riikka; Kuusanmäki, Heikki; Lievonen, Juha; Parsons, Alun; Suvela, Minna; Jantunen, Esa; Porkka, Kimmo; Heckman, Caroline A

    2017-08-22

    Novel agents have increased survival of multiple myeloma (MM) patients, however high-risk and relapsed/refractory patients remain challenging to treat and their outcome is poor. To identify novel therapies and aid treatment selection for MM, we assessed the ex vivo sensitivity of 50 MM patient samples to 308 approved and investigational drugs. With the results we i) classified patients based on their ex vivo drug response profile; ii) identified and matched potential drug candidates to recurrent cytogenetic alterations; and iii) correlated ex vivo drug sensitivity to patient outcome. Based on their drug sensitivity profiles, MM patients were stratified into four distinct subgroups with varied survival outcomes. Patients with progressive disease and poor survival clustered in a drug response group exhibiting high sensitivity to signal transduction inhibitors. Del(17p) positive samples were resistant to most drugs tested with the exception of histone deacetylase and BCL2 inhibitors. Samples positive for t(4;14) were highly sensitive to immunomodulatory drugs, proteasome inhibitors and several targeted drugs. Three patients treated based on the ex vivo results showed good response to the selected treatments. Our results demonstrate that ex vivo drug testing may potentially be applied to optimize treatment selection and achieve therapeutic benefit for relapsed/refractory MM.

  3. A simple nomogram for sample size for estimating sensitivity and specificity of medical tests

    Directory of Open Access Journals (Sweden)

    Malhotra Rajeev

    2010-01-01

    Full Text Available Sensitivity and specificity measure inherent validity of a diagnostic test against a gold standard. Researchers develop new diagnostic methods to reduce the cost, risk, invasiveness, and time. Adequate sample size is a must to precisely estimate the validity of a diagnostic test. In practice, researchers generally decide about the sample size arbitrarily either at their convenience, or from the previous literature. We have devised a simple nomogram that yields statistically valid sample size for anticipated sensitivity or anticipated specificity. MS Excel version 2007 was used to derive the values required to plot the nomogram using varying absolute precision, known prevalence of disease, and 95% confidence level using the formula already available in the literature. The nomogram plot was obtained by suitably arranging the lines and distances to conform to this formula. This nomogram could be easily used to determine the sample size for estimating the sensitivity or specificity of a diagnostic test with required precision and 95% confidence level. Sample size at 90% and 99% confidence level, respectively, can also be obtained by just multiplying 0.70 and 1.75 with the number obtained for the 95% confidence level. A nomogram instantly provides the required number of subjects by just moving the ruler and can be repeatedly used without redoing the calculations. This can also be applied for reverse calculations. This nomogram is not applicable for testing of the hypothesis set-up and is applicable only when both diagnostic test and gold standard results have a dichotomous category.

  4. Design and preliminary test of a free-air ionization chamber for low-energy X-ray

    Institute of Scientific and Technical Information of China (English)

    WU Jin-Jie; YANG Yuan-Di; WANG Pei-Wei; CHEN Jing; LIU Jia-Cheng

    2011-01-01

    A free-air ionization chamber in low-energy X-ray has been designed and manufactured at theNational Institute of Metrology (NIM, China) according to the defination of alr-kerma. The results of a preliminary test show that the leakage current of ionization chamber is around 2×10A, and the correction factor of ion recombination for the ionization chamber is also obtained. The free-air ionization chamber is suitable for the primary standard in low-energy X-rays.

  5. Effect of incubation temperature on the diagnostic sensitivity of the glanders complement fixation test.

    Science.gov (United States)

    Khan, I; Wieler, L H; Saqib, M; Melzer, F; Santana, V L D A; Neubauer, H; Elschner, M C

    2014-12-01

    The complement fixation test (CFT) is the only serological test prescribed by the World Organisation for Animal Health (OIE) for the diagnosis of glanders in international trading of equids. However, false-positive reactions have caused financial losses to the animal owners in the past, and false-negative tests have resulted in the introduction of glanders into healthy equine populations in previously glanders-free areas. Both warm (incubation at 37°C for 1 h) and cold (overnight incubation at 4°C) procedures are recommended by the OIE for serodiagnosis of glanders. In a comparison of the sensitivity and specificity of the two techniques, using the United States Department of Agriculture antigen, warm CFT was found to be significantly less sensitive (56.8%; p glanders but a lower diagnostic specificity has to be accepted. The immunoblot was used as the gold standard.

  6. ESTIMATION OF HIGHLY SENSITIVE TROPONIN TESTS IN THE DIAGNOSIS OF ACUTE CORONARY SYNDROME

    Directory of Open Access Journals (Sweden)

    L. V. Kremneva

    2016-01-01

    Full Text Available Review is devoted to the value of the use of highly sensitive troponin (hs-cTn tests in the diagnosis of acute coronary syndrome. The classification of the Tn-tests depending on their sensitivity is presented. The possible reasons of troponins appearance in blood of healthy people are shown. Authors consider a 3-hour algorithm for myocardial infarction (MI diagnostic, recommended by the expert group in 2012. Study results of 2011-2015 years are presented as the basis for the development of a one-hour MI diagnostic algorithm, recommended by the European Society of Cardiology in 2015. Authors discuss the results of studies showing that modern HS-cTnt tests (together with ECG assessment are capable to diagnose MI in the early stages. They significantly increase the number of identified MI, especially MI without ST segment elevation, as well as identify the group of patients with subsequent favorable prognosis.

  7. The sensitizing potential of metalworking fluid biocides (phenolic and thiazole compounds) in the guinea-pig maximization test in relation to patch-test reactivity in eczema patients

    Energy Technology Data Exchange (ETDEWEB)

    Andersen, K.E.; Hamann, K.

    1984-08-01

    The sensitizing potential of seven industrial antimicrobial agents was evaluated using the guinea-pig maximization test. Preventol O extra (o-phenylphenol) did not produce a sensitization reaction. Preventol ON extra (sodium salt of o-phenylphenol), Preventol GD (dichlorophene) and Proxel XL and HL containing 1,2-benzisothiazolin-3-one were weak sensitizers, while Preventol CMK and Preventol L, both containing chlorocresol, were classified as extreme potential sensitizers. Both the weak and the extreme experimental sensitizers are occasional human sensitizers. The interpretation of the test results is discussed.

  8. The sensitizing potential of metalworking fluid biocides (phenolic and thiazole compounds) in the guinea-pig maximization test in relation to patch-test reactivity in eczema patients

    DEFF Research Database (Denmark)

    Andersen, Klaus Ejner; Hamann, K

    1984-01-01

    containing 1,2-benzisothiazolin-3-one were weak sensitizers, while Preventol CMK and Preventol L, both containing chlorocresol, were classified as extreme potential sensitizers. Both the weak and the extreme experimental sensitizers are occasional human sensitizers. The interpretation of the test results......The sensitizing potential of seven industrial antimicrobial agents was evaluated using the guinea-pig maximization test. Preventol O extra (o-phenylphenol) did not produce a sensitization reaction. Preventol ON extra (sodium salt of o-phenylphenol), Preventol GD (dichlorophene) and Proxel XL and HL...

  9. Method-independent, Computationally Frugal Convergence Testing for Sensitivity Analysis Techniques

    Science.gov (United States)

    Mai, Juliane; Tolson, Bryan

    2017-04-01

    The increasing complexity and runtime of environmental models lead to the current situation that the calibration of all model parameters or the estimation of all of their uncertainty is often computationally infeasible. Hence, techniques to determine the sensitivity of model parameters are used to identify most important parameters or model processes. All subsequent model calibrations or uncertainty estimation procedures focus then only on these subsets of parameters and are hence less computational demanding. While the examination of the convergence of calibration and uncertainty methods is state-of-the-art, the convergence of the sensitivity methods is usually not checked. If any, bootstrapping of the sensitivity results is used to determine the reliability of the estimated indexes. Bootstrapping, however, might as well become computationally expensive in case of large model outputs and a high number of bootstraps. We, therefore, present a Model Variable Augmentation (MVA) approach to check the convergence of sensitivity indexes without performing any additional model run. This technique is method- and model-independent. It can be applied either during the sensitivity analysis (SA) or afterwards. The latter case enables the checking of already processed sensitivity indexes. To demonstrate the method independency of the convergence testing method, we applied it to three widely used, global SA methods: the screening method known as Morris method or Elementary Effects (Morris 1991, Campolongo et al., 2000), the variance-based Sobol' method (Solbol' 1993, Saltelli et al. 2010) and a derivative-based method known as Parameter Importance index (Goehler et al. 2013). The new convergence testing method is first scrutinized using 12 analytical benchmark functions (Cuntz & Mai et al. 2015) where the true indexes of aforementioned three methods are known. This proof of principle shows that the method reliably determines the uncertainty of the SA results when different

  10. Observing the Testing Effect using Coursera Video-Recorded Lectures: A Preliminary Study.

    Science.gov (United States)

    Yong, Paul Zhihao; Lim, Stephen Wee Hun

    2015-01-01

    We investigated the testing effect in Coursera video-based learning. One hundred and twenty-three participants either (a) studied an instructional video-recorded lecture four times, (b) studied the lecture three times and took one recall test, or (c) studied the lecture once and took three tests. They then took a final recall test, either immediately or a week later, through which their learning was assessed. Whereas repeated studying produced better recall performance than did repeated testing when the final test was administered immediately, testing produced better performance when the final test was delayed until a week after. The testing effect was observed using Coursera lectures. Future directions are documented.

  11. Development of an in vitro dendritic cell-based test for skin sensitizer identification.

    Science.gov (United States)

    Neves, Bruno Miguel; Rosa, Susana Carvalho; Martins, João Demétrio; Silva, Ana; Gonçalo, Margarida; Lopes, Maria Celeste; Cruz, Maria Teresa

    2013-03-18

    The sensitizing potential of chemicals is currently assessed using animal models. However, ethical and economic concerns and the recent European legislative framework triggered intensive research efforts in the development and validation of alternative methods. Therefore, the aim of this study was to develop an in vitro predictive test based on the analysis and integration of gene expression and intracellular signaling profiles of chemical-exposed skin-derived dendritic cells. Cells were treated with four known sensitizers and two nonsensitizers, and the effects on the expression of 20 candidate genes and the activation of MAPK, PI3K/Akt, and NF-κB signaling pathways were analyzed by real-time reverse transcription polymerase chain reaction and Western blotting, respectively. Genes Trxr1, Hmox1, Nqo1, and Cxcl10 and the p38 MAPK and JNK signaling pathways were identified as good predictor variables and used to construct a dichotomous classifier. For validation of the model, 12 new chemicals were then analyzed in a blind assay, and from these, 11 were correctly classified. Considering the total of 18 compounds tested here, 17 were correctly classified, representing a concordance of 94%, with a sensitivity of 92% (12 of 13 sensitizers identified) and a specificity of 100% (5 of 5 nonsensitizers identified). Additionally, we tested the ability of our model to discriminate sensitizers from nonallergenic but immunogenic compounds such as lipopolysaccharide (LPS). LPS was correctly classified as a nonsensitizer. Overall, our results indicate that the analysis of proposed gene and signaling pathway signatures in a mouse fetal skin-derived dendritic cell line represents a valuable model to be integrated in a future in vitro test platform.

  12. Reliability and sensitivity to change of the timed standing balance test in children with down syndrome

    Directory of Open Access Journals (Sweden)

    Vencita Priyanka Aranha

    2016-01-01

    Full Text Available Objective: To estimate the reliability and sensitivity to change of the timed standing balance test in children with Down syndrome (DS. Methods: It was a nonblinded, comparison study with a convenience sample of subjects consisting of children with DS (n = 9 aged 8–17 years. The main outcome measure was standing balance which was assessed using timed standing balance test, the time required to maintain in four conditions, eyes open static, eyes closed static, eyes open dynamic, and eyes closed dynamic. Results: Relative reliability was excellent for all four conditions with an Interclass Correlation Coefficient (ICC ranging from 0.91 to 0.93. The variation between repeated measurements for each condition was minimal with standard error of measurement (SEM of 0.21–0.59 s, suggestive of excellent absolute reliability. The sensitivity to change as measured by smallest real change (SRC was 1.27 s for eyes open static, 1.63 s for eyes closed static, 0.58 s for eyes open dynamic, and 0.61 s for eyes closed static. Conclusions: Timed standing balance test is an easy to administer test and sensitive to change with strong absolute and relative reliabilities, an important first step in establishing its utility as a clinical balance measure in children with DS.

  13. Computerized motion sensitivity screening tests in a multicountry rural onchocercal community survey in Africa

    Directory of Open Access Journals (Sweden)

    Babalola O

    2010-01-01

    Full Text Available Purpose: To determine whether the Wu-Jones Motion Sensitivity Screening Test (MSST accurately reflects the burden of optic nerve disease in several onchoendemic communities in Africa. Materials and Methods: The MSST was used to evaluate subjects in the communities of Raja in Sudan, Bushenyi in Uganda, Morogoro in Tanzania, and Ikon, Olomboro, and Gembu in Nigeria. Motion sensitivity was expressed as a percentage of motion detected in the individual eye, and this was averaged for the community. A perfectly normal eye would detect all motion and score 100%. Results: In this study, 3858 eyes of 2072 subjects were tested. The test was completed in 76% of respondents. Acceptability was high. Average test time was 120.4 s. The overall mean motion sensitivity of all eyes tested was 88.49%, ±17.49. Using a cutoff level of 50%, 6.4% of all subjects tested were subnormal. The highest proportion of subnormals recorded was in Morogoro at 12.7%. Severe defects in a community best correlated with optic nerve disease prevalence, while the proportion of the defect from a higher cutoff level best correlated with overall ocular morbidity. A repeat examination in the next 5 years following ivermectin treatment will show the influence, if any, on community-wide MSST performance. Conclusion: A wide range in community scores reflected disease diversity. The MSST appears to be a useful test in community-wide screening and diagnosis as it reflects the general level of ocular pathology and specifically, optic nerve disease.

  14. Sensitivity and validity of psychometric tests for assessing driving impairment: effects of sleep deprivation.

    Directory of Open Access Journals (Sweden)

    Stefan Jongen

    Full Text Available To assess drug induced driving impairment, initial screening is needed. However, no consensus has been reached about which initial screening tools have to be used. The present study aims to determine the ability of a battery of psychometric tests to detect performance impairing effects of clinically relevant levels of drowsiness as induced by one night of sleep deprivation.Twenty four healthy volunteers participated in a 2-period crossover study in which the highway driving test was conducted twice: once after normal sleep and once after one night of sleep deprivation. The psychometric tests were conducted on 4 occasions: once after normal sleep (at 11 am and three times during a single night of sleep deprivation (at 1 am, 5 am, and 11 am.On-the-road driving performance was significantly impaired after sleep deprivation, as measured by an increase in Standard Deviation of Lateral Position (SDLP of 3.1 cm compared to performance after a normal night of sleep. At 5 am, performance in most psychometric tests showed significant impairment. As expected, largest effect sizes were found on performance in the Psychomotor Vigilance Test (PVT. Large effects sizes were also found in the Divided Attention Test (DAT, the Attention Network Test (ANT, and the test for Useful Field of View (UFOV at 5 and 11 am during sleep deprivation. Effects of sleep deprivation on SDLP correlated significantly with performance changes in the PVT and the DAT, but not with performance changes in the UFOV.From the psychometric tests used in this study, the PVT and DAT seem most promising for initial evaluation of drug impairment based on sensitivity and correlations with driving impairment. Further studies are needed to assess the sensitivity and validity of these psychometric tests after benchmark sedative drug use.

  15. Geomechanical properties of Topopah Spring Tuff at the 0.5-m scale: preliminary results of compression tests at elevated temperature

    Energy Technology Data Exchange (ETDEWEB)

    Blair, S. C., LLNL

    1997-08-25

    This report presents preliminary results of laboratory testing of a small block sample of Topopah Spring Tuff. This is the first in a series of tests on small block samples. The purpose of these tests is to investigate the thermal-mechanical, thermal-hydrological, and thermal-chemical response of the rock to conditions similar to the near-field environment (NFE) of a potential nuclear waste repository. This report presents preliminary results of deformation and elastic- wave velocity measurements on a 0.5-m scale block of Topopah Spring tuff tested in uniaxial compression and at temperatures to 85{degrees}C.

  16. Preliminary test results from a free-piston Stirling engine technology demonstration program to support advanced radioisotope space power applications

    Science.gov (United States)

    White, Maurice A.; Qiu, Songgang; Augenblick, Jack E.

    2000-01-01

    Free-piston Stirling engines offer a relatively mature, proven, long-life technology that is well-suited for advanced, high-efficiency radioisotope space power systems. Contracts from DOE and NASA are being conducted by Stirling Technology Company (STC) for the purpose of demonstrating the Stirling technology in a configuration and power level that is representative of an eventual space power system. The long-term objective is to develop a power system with an efficiency exceeding 20% that can function with a high degree of reliability for up to 15 years on deep space missions. The current technology demonstration convertors (TDC's) are completing shakedown testing and have recently demonstrated performance levels that are virtually identical to projections made during the preliminary design phase. This paper describes preliminary test results for power output, efficiency, and vibration levels. These early results demonstrate the ability of the free-piston Stirling technology to exceed objectives by approximately quadrupling the efficiency of conventional radioisotope thermoelectric generators (RTG's). .

  17. Testing the recent snow drought as an analog for climate warming sensitivity of Cascades snowpacks

    Science.gov (United States)

    Cooper, Matthew G.; Nolin, Anne W.; Safeeq, Mohammad

    2016-08-01

    Record low snowpack conditions were observed at Snow Telemetry stations in the Cascades Mountains, USA during the winters of 2014 and 2015. We tested the hypothesis that these winters are analogs for the temperature sensitivity of Cascades snowpacks. In the Oregon Cascades, the 2014 and 2015 winter air temperature anomalies were approximately +2 °C and +4 °C above the climatological mean. We used a spatially distributed snowpack energy balance model to simulate the sensitivity of multiple snowpack metrics to a +2 °C and +4 °C warming and compared our modeled sensitivities to observed values during 2014 and 2015. We found that for each +1 °C warming, modeled basin-mean peak snow water equivalent (SWE) declined by 22%-30%, the date of peak SWE (DPS) advanced by 13 days, the duration of snow cover (DSC) shortened by 31-34 days, and the snow disappearance date (SDD) advanced by 22-25 days. Our hypothesis was not borne out by the observations except in the case of peak SWE; other snow metrics did not resemble predicted values based on modeled sensitivities and thus are not effective analogs of future temperature sensitivities. Rather than just temperature, it appears that the magnitude and phasing of winter precipitation events, such as large, late spring snowfall, controlled the DPS, SDD, and DSC.

  18. Velocity Measurements in Nasal Cavities by Means of Stereoscopic Piv - Preliminary Tests

    Science.gov (United States)

    Cozzi, Fabio; Felisati, Giovanni; Quadrio, Maurizio

    2017-08-01

    The prediction of detailed flow patterns in human nasal cavities using computational fluid dynamics (CFD) can provide essential information on the potential relationship between patient-specific geometrical characteristics of the nasal anatomy and health problems, and ultimately led to improved surgery. The complex flow structure and the intricate geometry of the nasal cavities make achieving such goals a challenge for CFD specialists. The need for experimental data to validate and improve the numerical simulations is particularly crucial. To this aim an experimental set-up based on Stereo PIV and a silicon phantom of nasal cavities have been designed and realized at Politecnico di Milano. This work describes the main features and challenges of the set-up along with some preliminary results.

  19. Preliminary benefit-cost analysis of the Fast Flux Test Facility (FFTF) power addition

    Energy Technology Data Exchange (ETDEWEB)

    Callaway, J.M.; Lezberg, A.J.; Scott, M.J.; Tawil, J.J.

    1984-07-01

    The primary objective of this report is to conduct a preliminary benefit-cost study for the proposed power addition to FFTF to determine whether the project is cost-effective. If the project is authorized, construction will begin in 1986 and end in 1991. Full power operation is scheduled to begin in 1991 and a project life of 20 years is assumed. The undiscounted cost during the construction period of the FFTF power addition is estimated to be approximately $117 million over the construction period (1984 dollars). An additional $3 million is estimated as the opportunity cost - or value of these resources in their most favorable alternative use - of surplus FFTF equipment and unused CRBR equipment, including materials for steam generator fabrication. The annual operating and maintenance cost of the project is estimated to be about $2.1 million in 1984 dollars. 20 references.

  20. Food Sensitivity in Children with Acute Urticaria in Skin Prick Test: Single Center Experience

    Directory of Open Access Journals (Sweden)

    Hatice Eke Gungor

    2015-11-01

    Full Text Available Aim: Families of children with acute urticaria often think that there is food allergy in children with urticaria and insist for skin tests. In this study, it was aimed to determine whether skin prick tests are necessary in cases presented with acute urticaria, in whom other causes of acute urticaria are excluded. Material and Method: A test panel involving cow milk, egg white, wheat, hazelnut, peanut, soybean, walnut, sesame, and tuna fish antigens was applied to the children presented with acute urticaria between 1 August 2013 and 1 August 2014, in whom other causes of acute urticaria were excluded and suspected food allergy was reported by parents. Results: Overall, 574 children aged 1-14 years were included to the study. Of the patients, sensitization against at least one food antigen was detected in 22.3% (128/574 of the patients. This rate was found to be 31.9% among those younger than 3 years, while 19.3% in those older than 3 years. Overall, sensitization rates against food allergen in panel were as follows: egg white, 7.3%; wheat, 3.3%; cow milk, 2.7%,; sesame, 2.8%; hazelnut, 2.4%; soybean, 2.3%; peanut, 1.9%, walnut, 1.6%; tuna fish, 1.6%. In general, the history of patients wasn%u2019t compatible with food sensitization detected. Discussion: Sensitization to food allergens is infrequent in children presented with acute urticaria, particularly among those older than 3 years despite expressions of parent and skin prick tests seems to be unnecessary unless strongly suggestive history is present.

  1. Identification of neutron irradiation induced strain rate sensitivity change using inverse FEM analysis of Charpy test

    Science.gov (United States)

    Haušild, Petr; Materna, Aleš; Kytka, Miloš

    2015-04-01

    A simple methodology how to obtain additional information about the mechanical behaviour of neutron-irradiated WWER 440 reactor pressure vessel steel was developed. Using inverse identification, the instrumented Charpy test data records were compared with the finite element computations in order to estimate the strain rate sensitivity of 15Ch2MFA steel irradiated with different neutron fluences. The results are interpreted in terms of activation volume change.

  2. Clonidine as a sensitizing agent in the forced swimming test for revealing antidepressant activity.

    OpenAIRE

    1991-01-01

    The forced swimming test (FST) in mice has failed to predict antidepressant activity for drugs having beta adrenoreceptor agonist activity and for serotonin uptake inhibitors. We investigated the potential for clonidine to render the FST sensitive to antidepressants by using a behaviorally inactive dose of this agent (0.1 mg/kg). All antidepressants studied (tricyclics, 5-HT uptake inhibitors, iprindole, mianserin, viloxazine, trazodone) showed either activity at lower doses or activity at pr...

  3. Observing the Testing Effect using Coursera Video-recorded Lectures: A Preliminary Study

    Directory of Open Access Journals (Sweden)

    Paul Zhihao eYONG

    2016-01-01

    Full Text Available We investigated the testing effect in Coursera video-based learning. One hundred and twenty-three participants either (a studied an instructional video-recorded lecture four times, (b studied the lecture three times and took one recall test, or (c studied the lecture once and took three tests. They then took a final recall test, either immediately or a week later, through which their learning was assessed. Whereas repeated studying produced better recall performance than did repeated testing when the final test was administered immediately, testing produced better performance when the final test was delayed until a week after. The testing effect was observed using Coursera lectures. Future directions are documented.

  4. Preliminary Computational Study for Future Tests in the NASA Ames 9 foot' x 7 foot Wind Tunnel

    Science.gov (United States)

    Pearl, Jason M.; Carter, Melissa B.; Elmiligui, Alaa A.; WInski, Courtney S.; Nayani, Sudheer N.

    2016-01-01

    The NASA Advanced Air Vehicles Program, Commercial Supersonics Technology Project seeks to advance tools and techniques to make over-land supersonic flight feasible. In this study, preliminary computational results are presented for future tests in the NASA Ames 9 foot x 7 foot supersonic wind tunnel to be conducted in early 2016. Shock-plume interactions and their effect on pressure signature are examined for six model geometries. Near- field pressure signatures are assessed using the CFD code USM3D to model the proposed test geometries in free-air. Additionally, results obtained using the commercial grid generation software Pointwise Reigistered Trademark are compared to results using VGRID, the NASA Langley Research Center in-house mesh generation program.

  5. Relative sensitivities of toxicity test protocols with the amphipods Eohaustorius estuarius and Ampelisca abdita.

    Science.gov (United States)

    Anderson, Brian S; Lowe, Sarah; Phillips, Bryn M; Hunt, John W; Vorhees, Jennifer; Clark, Sara; Tjeerdema, Ronald S

    2008-01-01

    A series of dose-response experiments was conducted to compare the relative sensitivities of toxicity test protocols using the amphipods Ampelisca abdita and Eohaustorius estuarius. A. abdita is one of the dominant infaunal species in the San Francisco Estuary, and E. estuarius is the primary sediment toxicity species used in the San Francisco Estuary Regional Monitoring Program. Experiments were conducted with a formulated sediment spiked with copper, fluoranthene, chlorpyrifos, and the three pyrethroid pesticides permethrin, bifenthrin, and cypermethrin, all chemicals of concern in this Estuary. The results showed that the protocol with A. abdita was more sensitive to fluoranthene and much more sensitive to copper, while E. estuarius was more sensitive to chlorpyrifos, and much more sensitive to the pyrethroid pesticides. These results, considered in conjunction with those from previous spiking studies [Weston, D.P., 1995. Further development of a chronic Ampelisca abdita bioassay as an indicator of sediment toxicity: summary and conclusions. In: Regional Monitoring Program for Trace Substances Annual Report. San Francisco Estuary Institute, Oakland, CA, pp 108-115; DeWitt, T.E., Swartz, R.C., Lamberson, J.O., 1989. Measuring the acute toxicity of estuarine sediments. Environ. Toxicol. Chem. 8: 1035-1048; DeWitt, T.H.E., Pinza, M.R., Niewolny, L.A., Cullinan, V.I., Gruendell, B.D., 1997. Development and evaluation of a standard marine/estuarine chronic sediment toxicity method using Leptocheirus plumulosus. Draft report prepared for the US Environmental Protection Agency, Office of Science and Technology, Washington DC, under contract DE-AC06-76RLO 1830 by Batelle Marine Science Laboratory, Battelle Memorial Institute, Pacific Northwest Division, Richland, WA], suggest that, in general, A. abdita is more sensitive to metals, E. estuarius is more sensitive to pesticides, and both protocols have roughly comparable sensitivities to hydrocarbons. The preponderance of

  6. 31P-MRS of skeletal muscle is not a sensitive diagnostic test for mitochondrial myopathy

    DEFF Research Database (Denmark)

    Jeppesen, Tina Dysgaard; Quistorff, Bjørn; Wibrand, Flemming

    2007-01-01

    impaired citrate synthase-corrected complex I activity. Resting PCr/P(i) ratio and leg P(i) recovery were lower in MM patients vs. healthy subjects. PCr and ATP production after exercise were similar in patients and healthy subjects. Although the specificity for MM of some (31)P-MRS variables was as high...... as 100%, the sensitivity was low (0-63%) and the diagnostic strength of (31)P-MRS was inferior to the other diagnostic tests for MM. Thus, (31)P-MRS should not be a routine test for MM, but may be an important research tool....

  7. A robust hypothesis test for the sensitive detection of constant speed radiation moving sources

    Energy Technology Data Exchange (ETDEWEB)

    Dumazert, Jonathan, E-mail: jonathan.dumazert@cea.fr [CEA, LIST, Laboratoire Capteurs Architectures Electroniques, 91191 Gif-sur-Yvette (France); Coulon, Romain; Kondrasovs, Vladimir; Boudergui, Karim; Moline, Yoann; Sannié, Guillaume; Gameiro, Jordan; Normand, Stéphane [CEA, LIST, Laboratoire Capteurs Architectures Electroniques, 91191 Gif-sur-Yvette (France); Méchin, Laurence [CNRS, UCBN, Groupe de Recherche en Informatique, Image, Automatique et Instrumentation de Caen, 14050 Caen (France)

    2015-09-21

    Radiation Portal Monitors are deployed in linear networks to detect radiological material in motion. As a complement to single and multichannel detection algorithms, inefficient under too low signal-to-noise ratios, temporal correlation algorithms have been introduced. Test hypothesis methods based on empirically estimated mean and variance of the signals delivered by the different channels have shown significant gain in terms of a tradeoff between detection sensitivity and false alarm probability. This paper discloses the concept of a new hypothesis test for temporal correlation detection methods, taking advantage of the Poisson nature of the registered counting signals, and establishes a benchmark between this test and its empirical counterpart. The simulation study validates that in the four relevant configurations of a pedestrian source carrier under respectively high and low count rate radioactive backgrounds, and a vehicle source carrier under the same respectively high and low count rate radioactive backgrounds, the newly introduced hypothesis test ensures a significantly improved compromise between sensitivity and false alarm. It also guarantees that the optimal coverage factor for this compromise remains stable regardless of signal-to-noise ratio variations between 2 and 0.8, therefore allowing the final user to parametrize the test with the sole prior knowledge of background amplitude.

  8. Hypersensitivity testing for Aspergillus fumigatus IgE is significantly more sensitive than testing for Aspergillus niger IgE.

    Science.gov (United States)

    Selvaggi, Thomas A; Walco, Jeremy P; Parikh, Sujal; Walco, Gary A

    2012-02-01

    We sought to determine if sufficient redundancy exists between specific IgE testing for Aspergillus fumigatus and Aspergillus niger to eliminate one of the assays in determining Aspergillus hypersensitivity. We reviewed regional laboratory results comparing A fumigatus-specific IgE with A niger-specific IgE using the Pharmacia UniCAP system (Pharmacia, Kalamazoo, MI). By using the Fisher exact test as an index of concordance among paired results, we showed a significant difference between 109 paired samples for the presence of specific IgE to A fumigatus and A niger (P niger; no specimen was positive for A niger and negative for A fumigatus. We conclude that A fumigatus-specific IgE is sufficient to detect Aspergillus hypersensitivity. The assay for A niger-specific IgE is redundant, less sensitive, and unnecessary if the assay for specific IgE for A fumigatus is performed.

  9. An evaluation of the relative sensitivities of the venereal disease research laboratory test and the Treponema pallidum particle agglutination test among patients diagnosed with primary syphilis.

    Science.gov (United States)

    Creegan, Linda; Bauer, Heidi M; Samuel, Michael C; Klausner, Jeffrey; Liska, Sally; Bolan, Gail

    2007-12-01

    Because definitive methods for diagnosing primary syphilis are limited, it is important to optimize the sensitivity of serodiagnosis. To determine the most sensitive testing approach to the diagnosis of primary syphilis, using the commonly available serologic tests: the Venereal Disease Research Laboratory (VDRL) test and the Treponema pallidum particle agglutination (TP-PA) test. Sensitivities of 2 serologic testing strategies for primary syphilis were compared among 106 darkfield-confirmed cases treated in San Francisco from January 2002 through December 2004. The sensitivity of the diagnostic strategy using VDRL confirmed by TP-PA was 71% (95% CI, 61%-79%). Substituting Rapid Plasma Reagin test for VDRL in a subset of 51 patients produced the same sensitivity (71%; 95% CI, 56%-83%). The sensitivity of TP-PA as the first-line diagnostic test was 86% (95% CI, 78%-92%). The sensitivity of the former approach was significantly lower among HIV-positive patients, compared with HIV-negative patients (55% vs. 77%, P = 0.05). The TP-PA test as the first-line diagnostic test yielded higher sensitivity for primary syphilis than did the use of the currently recommended strategy.

  10. Preliminary evaluation of a micro-based repeated measures testing system

    Science.gov (United States)

    Kennedy, Robert S.; Wilkes, Robert L.; Lane, Norman E.

    1985-01-01

    A need exists for an automated performance test system to study the effects of various treatments which are of interest to the aerospace medical community, i.e., the effects of drugs and environmental stress. The ethics and pragmatics of such assessment demand that repeated measures in small groups of subjects be the customary research paradigm. Test stability, reliability-efficiency and factor structure take on extreme significance; in a program of study by the U.S. Navy, 80 percent of 150 tests failed to meet minimum metric requirements. The best is being programmed on a portable microprocessor and administered along with tests in their original formats in order to examine their metric properties in the computerized mode. Twenty subjects have been tested over four replications on a 6.0 minute computerized battery (six tests) and which compared with five paper and pencil marker tests. All tests achieved stability within the four test sessions, reliability-efficiencies were high (r greater than .707 for three minutes testing), and the computerized tests were largely comparable to the paper and pencil version from which they were derived. This computerized performance test system is portable, inexpensive and rugged.

  11. Preliminary Research Employing the Watson-Barker Listening Test: A Validation of the Instrument.

    Science.gov (United States)

    Roberts, Charles V.

    A study was conducted to further validate the "Watson-Barker Listening Test." The subjects, 120 students enrolled in basic speech courses, completed the Receiver Apprehension Test (RAT) and the Watson-Barker Listening Test: Form A. Statistical analysis of the results revealed a significant correlation between the RAT scores and both the long term…

  12. Evaluation of 5-fluorouracil applicability by multi-point collagen gel droplet embedded drug sensitivity test.

    Science.gov (United States)

    Ochiai, Takumi; Nishimura, Kazuhiko; Noguchi, Hajime; Kitajima, Masayuki; Tsuruoka, Yuko; Takahashi, Yuka

    2005-07-01

    The drug sensitivity of tumor cells is one of key issues to explore individualized therapy for cancer patients. One of such methods is in vitro anticancer drug sensitivity test which is generally based on one drug concentration and contact time. In this study, 5-fluorouracil (5-FU) sensitivity of cancer cells from colorectal cancer patients was evaluated by collagen gel droplet embedded drug sensitivity test (CD-DST) under multiple drug concentrations and contact durations. Cancer cells from 19 patients were measured for 9 drug concentration/contact time conditions (cohort 1) and from 34 patients were measured for 2 drug concentration/contact time conditions (cohort 2) using CD-DST. There was not significant difference in growth inhibition rate for 1.0 microg/ml for 24 h and 0.2 microg/ml for 120 h, which gives the same area under the curve (AUC) (p=0.832) in all 53 patients (cohort 1 and 2). In cohort 1, 9 conditions were successfully measured in 18 of 19 cohort 1 patients (94.7%). The drug concentrations and growth inhibition rate approximated to logarithmic curve for all 3 contact times and 50% inhibitory concentration (IC50) values at 3 contact times could be calculated in these 18 patients. Growth inhibition rate and AUC also approximated to logarithmic curve. These values varied several orders of magnitude among patients. In vitro antitumor effect of 5-FU depended on AUC in colorectal tumor and it might support the use of continuous infusion or oral therapy which generates significant AUC with manageable toxicity. Some patients demonstrating low 5-FU sensitivity could not be indicated for 5-FU based therapy, and non-5-FU therapy should be explored for them.

  13. Testing the sensitivity and specificity of the fluorescence microscope (Cyscope® for malaria diagnosis

    Directory of Open Access Journals (Sweden)

    Mudathir Mahmoud A

    2010-03-01

    Full Text Available Abstract Background Early diagnosis and treatment of malaria are necessary components in the control of malaria. The gold standard light microscopy technique has high sensitivity, but is a relatively time-consuming procedure especially during epidemics and in areas of high endemicity. This study attempted to test the sensitivity and specificity of a new diagnostic tool - the Cyscope® fluorescence microscope, which is based on the use of Plasmodium nucleic acid-specific fluorescent dyes to facilitate detection of the parasites even in low parasitaemia conditions due to the contrast with the background. Methods In this study, 293 febrile patients above the age of 18 years attending the malaria treatment centre in Sinnar State (Sudan were interviewed using a structured questionnaire. Finger-prick blood samples were also collected from the participants to be tested for malaria using the hospital's microscope, the reference laboratory microscope, as well as the Cyscope® microscope. The results of the investigations were then used to calculate the sensitivity, specificity, and positive and negative predictive values of the Cyscope® microscope in reference to gold standard light microscopy. Results The sensitivity was found to be 98.2% (95% CI: 90.6%-100%; specificity = 98.3% (95% CI: 95.7% - 99.5%; positive predictive value = 93.3% (95% CI: 83.8% - 98.2%; and negative predictive value = 99.6% (95% CI: 97.6% - 100%. Conclusions In conclusion, the Cyscope® microscope was found to be sensitive, specific and provide rapid, reliable results in a matter of less than 10 minutes. The Cyscope® microscope should be considered as a viable, cheaper and time-saving option for malaria diagnosis, especially in areas where Plasmodium falciparum is the predominant parasite.

  14. Highly sensitive multianalyte immunochromatographic test strip for rapid chemiluminescent detection of ractopamine and salbutamol

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Hongfei; Han, Jing; Yang, Shijia; Wang, Zhenxing; Wang, Lin; Fu, Zhifeng, E-mail: fuzf@swu.edu.cn

    2014-08-11

    Graphical abstract: A multianalyte immunochromatographic test strip was developed for the rapid detection of two β{sub 2}-agonists. Due to the application of chemiluminescent detection, this quantitative method shows much higher sensitivity. - Highlights: • An immunochromatographic test strip was developed for detection of multiple β{sub 2}-agonists. • The whole assay process can be completed within 20 min. • The proposed method shows much higher sensitivity due to the application of CL detection. • It is a portable analytical tool suitable for field analysis and rapid screening. - Abstract: A novel immunochromatographic assay (ICA) was proposed for rapid and multiple assay of β{sub 2}-agonists, by utilizing ractopamine (RAC) and salbutamol (SAL) as the models. Owing to the introduction of chemiluminescent (CL) approach, the proposed protocol shows much higher sensitivity. In this work, the described ICA was based on a competitive format, and horseradish peroxidase-tagged antibodies were used as highly sensitive CL probes. Quantitative analysis of β{sub 2}-agonists was achieved by recording the CL signals of the probes captured on the two test zones of the nitrocellulose membrane. Under the optimum conditions, RAC and SAL could be detected within the linear ranges of 0.50–40 and 0.10–50 ng mL{sup −1}, with the detection limits of 0.20 and 0.040 ng mL{sup −1} (S/N = 3), respectively. The whole process for multianalyte immunoassay of RAC and SAL can be completed within 20 min. Furthermore, the test strip was validated with spiked swine urine samples and the results showed that this method was reliable in measuring β{sub 2}-agonists in swine urine. This CL-based multianalyte test strip shows a series of advantages such as high sensitivity, ideal selectivity, simple manipulation, high assay efficiency and low cost. Thus, it opens up new pathway for rapid screening and field analysis, and shows a promising prospect in food safety.

  15. Timing and presence of an attachment person affect sensitivity of aggression tests in shelter dogs.

    Science.gov (United States)

    Kis, A; Klausz, B; Persa, E; Miklósi, Á; Gácsi, M

    2014-02-22

    Different test series have been developed and used to measure behaviour in shelter dogs in order to reveal individuals not suitable for re-homing due to their aggressive tendencies. However, behavioural tests previously validated on pet dogs seem to have relatively low predictability in the case of shelter dogs. Here, we investigate the potential effects of (1) timing of the behaviour testing and (2) presence of a human companion on dogs' aggressive behaviour. In Study I, shelter dogs (n=25) showed more aggression when tested in a short test series two weeks after they had been placed in the shelter compared to their responses in the same test performed 1-2 days after arrival. In Study II, the occurrence of aggressive behaviour was more probable in pet dogs (n=50) in the presence than in the absence of their passive owner. We conclude that the sensitivity of aggression tests for shelter dogs can be increased by running the test in the presence of a caretaker, and after some period of acclimatisation to the new environment. This methodology could also provide better chances for successful adoption.

  16. Preliminary Multirod Burst Test Program results and implications of interest to reactor safety evaluations

    Energy Technology Data Exchange (ETDEWEB)

    Chapman, R.H. (comp.)

    1978-01-01

    The Multirod Burst Test (MRBT) Program, in progress at Oak Ridge National Laboratory, is investigating LWR cladding deformation in single- and multirod test arrays under conditions representative of reflood and refill phases of a LOCA. In these tests internally pressurized, unirradiated Zircaloy-4 tubes containing electrically heated fuel simulators are tested to failure in a low-pressure, superheated-steam environment. The tubes are ''uniformly'' heated over a 915-mm length; the simulator pressure, due to the small enclosed gas volume, also varies with temperature (and deformation) during the test. Two 4 x 4 multirod tests (B-1 and B-2), one with and one without the shroud being heated, have been conducted with a bundle heating rate of approx. 29/sup 0/C/sec; initial pressure conditions for these tests were selected to cause failure at about 860/sup 0/C. An additional 4 x 4 array (B-3) was tested using a bundle heating rate of approx. 10/sup 0/C/sec; the shroud was also heated in this test. Initial conditions were adjusted to cause failure at approx. 760/sup 0/C. Posttest examination (including flow tests) of the B-1 and B-2 test arrays, is essentially complete, and pertinent data are included in this summary.

  17. Preliminary Observations on Sensitivity and Specificity of Magnetization Transfer Asymmetry for Imaging Myelin of Rat Brain at High Field.

    Science.gov (United States)

    Kim, Jae-Woong; Choi, Jiye; Cho, Janggeun; Lee, Chulhyun; Jeon, Daejong; Park, Sung-Hong

    2015-01-01

    Magnetization transfer ratio (MTR) has been often used for imaging myelination. Despite its high sensitivity, the specificity of MTR to myelination is not high because tissues with no myelin such as muscle can also show high MTR. In this study, we propose a new magnetization transfer (MT) indicator, MT asymmetry (MTA), as a new method of myelin imaging. The experiments were performed on rat brain at 9.4 T. MTA revealed high signals in white matter and significantly low signals in gray matter and muscle, indicating that MTA has higher specificity than MTR. Demyelination and remyelination studies demonstrated that the sensitivity of MTA to myelination was as high as that of MTR. These experimental results indicate that MTA can be a good biomarker for imaging myelination. In addition, MTA images can be efficiently acquired with an interslice MTA method, which may accelerate clinical application of myelin imaging.

  18. A Cytoplasmic Form of Gaussia luciferase Provides a Highly Sensitive Test for Cytotoxicity

    Science.gov (United States)

    Tsuji, Saori; Ohbayashi, Tetsuya; Yamakage, Kohji; Oshimura, Mitsuo; Tada, Masako

    2016-01-01

    The elimination of unfavorable chemicals from our environment and commercial products requires a sensitive and high-throughput in vitro assay system for drug-induced hepatotoxicity. Some previous methods for evaluating hepatotoxicity measure the amounts of cytoplasmic enzymes secreted from damaged cells into the peripheral blood or culture medium. However, most of these enzymes are proteolytically digested in the extracellular milieu, dramatically reducing the sensitivity and reliability of such assays. Other methods measure the decrease in cell viability following exposure to a compound, but such endpoint assays are often confounded by proliferation of surviving cells that replace dead or damaged cells. In this study, with the goal of preventing false-negative diagnoses, we developed a sensitive luminometric cytotoxicity test using a stable form of luciferase. Specifically, we converted Gaussia luciferase (G-Luc) from an actively secreted form to a cytoplasmic form by adding an ER-retention signal composed of the four amino acids KDEL. The bioluminescent signal was >30-fold higher in transgenic HepG2 human hepatoblastoma cells expressing G-Luc+KDEL than in cells expressing wild-type G-Luc. Moreover, G-Luc+KDEL secreted from damaged cells was stable in culture medium after 24 hr at 37°C. We evaluated the accuracy of our cytotoxicity test by subjecting identical samples obtained from chemically treated transgenic HepG2 cells to the G-Luc+KDEL assay and luminometric analyses based on secretion of endogenous adenylate kinase or cellular ATP level. Time-dependent accumulation of G-Luc+KDEL in the medium increased the sensitivity of our assay above those of existing tests. Our findings demonstrate that strong and stable luminescence of G-Luc+KDEL in human hepatocyte-like cells, which have high levels of metabolic activity, make it suitable for use in a high-throughput screening system for monitoring time-dependent cytotoxicity in a limited number of cells. PMID

  19. Development and Preliminary Testing of a High Precision Long Stroke Slit Change Mechanism for the SPICE Instrument

    Science.gov (United States)

    Paciotti, Gabriel; Humphries, Martin; Rottmeier, Fabrice; Blecha, Luc

    2014-01-01

    In the frame of ESA's Solar Orbiter scientific mission, Almatech has been selected to design, develop and test the Slit Change Mechanism of the SPICE (SPectral Imaging of the Coronal Environment) instrument. In order to guaranty optical cleanliness level while fulfilling stringent positioning accuracies and repeatability requirements for slit positioning in the optical path of the instrument, a linear guiding system based on a double flexible blade arrangement has been selected. The four different slits to be used for the SPICE instrument resulted in a total stroke of 16.5 mm in this linear slit changer arrangement. The combination of long stroke and high precision positioning requirements has been identified as the main design challenge to be validated through breadboard models testing. This paper presents the development of SPICE's Slit Change Mechanism (SCM) and the two-step validation tests successfully performed on breadboard models of its flexible blade support system. The validation test results have demonstrated the full adequacy of the flexible blade guiding system implemented in SPICE's Slit Change Mechanism in a stand-alone configuration. Further breadboard test results, studying the influence of the compliant connection to the SCM linear actuator on an enhanced flexible guiding system design have shown significant enhancements in the positioning accuracy and repeatability of the selected flexible guiding system. Preliminary evaluation of the linear actuator design, including a detailed tolerance analyses, has shown the suitability of this satellite roller screw based mechanism for the actuation of the tested flexible guiding system and compliant connection. The presented development and preliminary testing of the high-precision long-stroke Slit Change Mechanism for the SPICE Instrument are considered fully successful such that future tests considering the full Slit Change Mechanism can be performed, with the gained confidence, directly on a

  20. Quantitative patch and repeated open application testing in methyldibromo glutaronitrile-sensitive patients.

    Science.gov (United States)

    Schnuch, A; Kelterer, D; Bauer, A; Schuster, Ch; Aberer, W; Mahler, V; Katzer, K; Rakoski, J; Jappe, U; Krautheim, A; Bircher, A; Koch, P; Worm, M; Löffler, H; Hillen, U; Frosch, P J; Uter, W

    2005-04-01

    Contact allergy to methyldibromo glutaronitrile (MDBGN), often combined with phenoxyethanol (PE) (e.g., Euxyl K 400), increased throughout the 1990s in Europe. Consequently, in 2003, the European Commission banned its use in leave-on products, where its use concentration was considered too high and the non-sensitizing use concentration as yet unknown. The 2 objectives of the study are (a) to find a maximum non-eliciting concentration in a leave-on product in MDBGN/PE-sensitized patients, which could possibly also be considered safe regarding induction and (b) to find the best patch test concentration for MDBGN. We, therefore, performed a use-related test (ROAT) in patients sensitized to MDBGN/PE (n = 39) with 3 concentrations of MDBGN/PE (50, 100 and 250 p.p.m. MDBGN, respectively). A subset of these patients (n = 24) was later patch-tested with various concentrations (0.1, 0.2, 0.3 and 0.5% MDBGN, respectively). 15 patients (38%, 95% confidence interval (CI) = 23-55%) had a negative and 24 (62%; 95% CI = 45-77%) a positive overall repeated open application test (ROAT) result. 13 reacted to the lowest (50 p.p.m.), 8 to the middle (100 p.p.m.) and 3 to the highest concentration (250 p.p.m.) only. In those 13 reacting to the lowest ROAT concentration, dermatitis developed within a few days (1-7). The strength of the initial and the confirmatory patch test result, respectively, and the outcome of the ROAT were positively associated. Of the 24 patients with a use and confirmatory patch test, 15 reacted to 0.1% MDBGN, 16 to 0.2%, 17 to 0.3% and 22 to 0.5%. With the patch test concentration of 0.5%, the number of ROAT-negative patients but patch-test-positive patients increases considerably, particularly due to + reactions. A maximum sensitivity of 94% (95% CI = 70-100%) is reached with a patch test concentration of 0.2%, and is not further improved by increasing the concentration. However, the specificity decreases dramatically from 88 (95% CI = 47-100%) with 0.2% to a

  1. Preliminary study of novel, timed walking tests for children with spina bifida or cerebral palsy

    Science.gov (United States)

    Kane, Kyra J; Lanovaz, Joel; Bisaro, Derek; Oates, Alison; Musselman, Kristin E

    2016-01-01

    Objective: Walking assessment is an important aspect of rehabilitation practice; yet, clinicians have few psychometrically sound options for evaluating walking in highly ambulatory children. The purpose of this study was to evaluate the validity and reliability of two new measures of walking function—the Obstacles and Curb tests—relative to the 10-Meter Walk test and Timed Up and Go test in children with spina bifida or cerebral palsy. Methods: A total of 16 ambulatory children with spina bifida (n=9) or cerebral palsy (n=7) (9 boys; mean age 7years, 7months; standard deviation 3years, 4months) and 16 age- and gender-matched typically developing children participated. Children completed the walking tests, at both self-selected and fast speeds, twice. To evaluate discriminative validity, scores were compared between typically developing and spina bifida/cerebral palsy groups. Within the spina bifida/cerebral palsy group, inter-test correlations evaluated convergent validity and intraclass correlation coefficients evaluated within-session test–retest reliability. Results: At fast speeds, all tests showed discriminative validity (p<0.006 for typically developing and spina bifida/cerebral palsy comparisons) and convergent validity (rho=0.81–0.90, p⩽0.001, for inter-test correlations). At self-selected speeds, only the Obstacles test discriminated between groups (p=0.001). Moderately strong correlations (rho=0.73–0.78, p⩽0.001) were seen between the 10-Meter Walk test, Curb test, and Timed Up and Go test. Intraclass correlation coefficients ranged from 0.81 to 0.97, with higher test–retest reliability for tests performed at fast speeds rather than self-selected speeds. Conclusion: The Obstacles and Curb tests are promising measures for assessing walking in this population. Performing tests at fast walking speeds may improve their validity and test–retest reliability for children with spina bifida/cerebral palsy. PMID:27493754

  2. A novel hot-plate test sensitive to hyperalgesic stimuli and non-opioid analgesics

    Directory of Open Access Journals (Sweden)

    T.R. Lavich

    2005-03-01

    Full Text Available It is widely accepted that the classical constant-temperature hot-plate test is insensitive to cyclooxygenase inhibitors. In the current study, we developed a variant of the hot-plate test procedure (modified hot-plate (MHP test to measure inflammatory nociception in freely moving rats and mice. Following left and right hind paw stimulation with a phlogogen and vehicle, respectively, the animals were placed individually on a hot-plate surface at 51ºC and the withdrawal latency for each paw was determined simultaneously in measurements performed at 15, 60, 180, and 360 min post-challenge. Plantar stimulation of rats (250 and 500 µg/paw and mice (125-500 µg/paw with carrageenan led to a rapid hyperalgesic response of the ipsilateral paw that reached a plateau from 15 to 360 min after challenge. Pretreatment with indomethacin (4 mg/kg, ip inhibited the phenomenon at all the times analyzed. Similarly, plantar stimulation of rats and mice with prostaglandin E2 (0.5 and 1 µg/paw also resulted in rapid hyperalgesia which was first detected 15 min post-challenge. Finally, we observed that the MHP test was more sensitive than the classical Hargreaves' test, being able to detect about 4- and 10-fold lower doses of prostaglandin E2 and carrageenan, respectively. In conclusion, the MHP test is a simple and sensitive method for detecting peripheral hyperalgesia and analgesia in rats and mice. This test represents a low-cost alternative for the study of inflammatory pain in freely moving animals.

  3. A novel hot-plate test sensitive to hyperalgesic stimuli and non-opioid analgesics.

    Science.gov (United States)

    Lavich, T R; Cordeiro, R S B; Silva, P M R; Martins, M A

    2005-03-01

    It is widely accepted that the classical constant-temperature hot-plate test is insensitive to cyclooxygenase inhibitors. In the current study, we developed a variant of the hot-plate test procedure (modified hot-plate (MHP) test) to measure inflammatory nociception in freely moving rats and mice. Following left and right hind paw stimulation with a phlogogen and vehicle, respectively, the animals were placed individually on a hot-plate surface at 51 degrees C and the withdrawal latency for each paw was determined simultaneously in measurements performed at 15, 60, 180, and 360 min post-challenge. Plantar stimulation of rats (250 and 500 microg/paw) and mice (125-500 microg/paw) with carrageenan led to a rapid hyperalgesic response of the ipsilateral paw that reached a plateau from 15 to 360 min after challenge. Pretreatment with indomethacin (4 mg/kg, i.p.) inhibited the phenomenon at all the times analyzed. Similarly, plantar stimulation of rats and mice with prostaglandin E2 (0.5 and 1 microg/paw) also resulted in rapid hyperalgesia which was first detected 15 min post-challenge. Finally, we observed that the MHP test was more sensitive than the classical Hargreaves' test, being able to detect about 4- and 10-fold lower doses of prostaglandin E2 and carrageenan, respectively. In conclusion, the MHP test is a simple and sensitive method for detecting peripheral hyperalgesia and analgesia in rats and mice. This test represents a low-cost alternative for the study of inflammatory pain in freely moving animals.

  4. Dual luminophor pressure-sensitive paint: III. Application to automotive model testing

    Science.gov (United States)

    Gouterman, Martin; Callis, James; Dalton, Larry; Khalil, Gamal; Mébarki, Youssef; Cooper, Kevin R.; Grenier, Michel

    2004-10-01

    Porphyrins play key roles in natural energy conversion systems, including photosynthesis and oxygen transport. Because of their chemical stability, unique optical properties and synthetic versatility, porphyrins are well suited as chemical sensors. One successful application is the use of platinum porphyrin (PtP) in pressure-sensitive paint (PSP). Oxygen in the film quenches luminescence, and oxygen pressure was initially monitored by measuring the ratio of I(wind-off)/I(wind-on). But this ratio is compromised if there is model motion and if the paint layer is inhomogeneous. Furthermore it requires careful monitoring and placement of light sources. Moreover, this method is seriously affected by temperature. The errors caused by model motion and temperature sensitivity are eliminated or greatly reduced using dual luminophor paint. This paper illustrates a successful application of a dual luminophor PSP in auto model testing. The PSP is made from an oxygen sensitive luminophor, Pt tetra(pentafluorophenyl)-porpholactone, which provides Isen, and Mg tetra(pentafluorophenyl)porphine, which provides temperature-sensitive paint (TSP) as the pressure-independent reference. The ratio PSP/TSP in the FIB polymer produced ideal PSP measurements with a very low-temperature dependence of -0.1% °C-1.

  5. Air STAR Beyond Visual Range UAS Description and Preliminary Test Results

    Science.gov (United States)

    Cunningham, Kevin; Cox, David E.; Foster, John V.; Riddick, Stephen E.; Laughter, Sean A.

    2016-01-01

    The NASA Airborne Subscale Transport Aircraft Research Unmanned Aerial System project's capabilities were expanded by updating the system design and concept of operations. The new remotely piloted airplane system design was flight tested to assess integrity and operational readiness of the design to perform flight research. The purpose of the system design is to improve aviation safety by providing a capability to validate, in high-risk conditions, technologies to prevent airplane loss of control. Two principal design requirements were to provide a high degree of reliability and that the new design provide a significant increase in test volume (relative to operations using the previous design). The motivation for increased test volume is to improve test efficiency and allow new test capabilities that were not possible with the previous design and concept of operations. Three successful test flights were conducted from runway 4-22 at NASA Goddard Space Flight Center's Wallops Flight Facility.

  6. Protein Profiling on Meglumine Antimoniate (Glucantime® Sensitive and Resistant L. tropica Isolates by 2- Dimentional Gel Electrophoresis: A Preliminary Study

    Directory of Open Access Journals (Sweden)

    R Hadighi

    2009-02-01

    Full Text Available Background: Glucantime® is the first- line drug for the treatment of all forms of leishmaniasis. Unfortunately, the prevalence of parasites becoming resistant to Glucantime® is increasing in several parts of the world including Iran. As protein is the most important target for drugs in response to a variety of signals including drugs so, it seems expression protein patterns in sensitive and resistant Leishmania parasites could greatly help us about the mechanisms of responses to antileishmanial drugs. In this study, we used 2-dimentional gel electrophoresis (2-DE method to determine protein expression profiles between drug (Glucantime® sensitive and resistant Leishmania tropica isolated from Iranian an­throponotic cutaneous leishmaniasis (ACL patients."nMethods: We used from the two confirmed genetically of Glucantime® sensitive (Mash-4 and resistant (Mash-927 field strains of L. tropica, isolated from ACL patients in north eastern Iran. The two Leishmania isolates were cultured, promastigotes were harvested followed by protein extraction using TCA/Aceton to study protein profiling, 2-DE was done and gels stained with silver nitrate."nResults: At least 2236 distinct protein spots were detected. Twelve spots out of them, showed significant changes in expression in resistant compared to sensitive isolates. Of these, 11 protein spots were up- and one was down-regulated."nConclusions: This preliminary study has showed that a number of proteins differentially expressed in drug (Glucan­time® resistance L. tropica and probably the role of these proteins are increasing the parasite resistance against the drug and delay in cell death.

  7. Cyclosporine pharmacological efficacy estimated by lymphocyte immunosuppressant sensitivity test before and after renal transplantation.

    Science.gov (United States)

    Sugiyama, K; Isogai, K; Toyama, A; Satoh, H; Saito, K; Nakagawa, Y; Tasaki, M; Takahashi, K; Saito, N; Hirano, T

    2009-10-01

    Lymphocyte immunosuppressant sensitivity test (LIST) is useful for predicting the pharmacological efficacy of immunosuppressive agents. In this study, the pharmacological efficacy of cyclosporine was estimated by LIST before and after renal transplantation. Lymphocyte immunosuppressant sensitivity test was performed by the 3-(4,5-dimethylthiazol-2-yl)-2,5diphenyltetrazolium bromide (MTT) assay before and at 1, 3, and 12 months after transplantation in 19 consecutive renal transplant recipients. There was wide intersubject variability in cyclosporine IC50 before transplantation [Mean (SD) of 593.9 (1067.6) ng/mL]. This variability worsened 1 month after transplantation [525.7 (1532.7) ng/mL] but decreased at 3 months (193.5 (347.9) ng/mL) and 12 months (75.4 (95.4) ng/mL). In this small study, observed differences in IC50 values for the individual subjects at various time intervals was not associated with the occurrence of rejection, graft loss, and infection episodes. Lymphocyte sensitivity to cyclosporine assessed by the LIST assay showed a high level of inter-subject variability particularly before and 1 month after transplantation. The observed difference in IC50 values was not associated with clinical outcome in this small study.

  8. Sensitivity Tests for the Unprotected Events of the Prototype Gen-IV SFR

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Chiwoong; Lee, Kwilim; Jeong, Jaeho; Yu, Jin; An, Sangjun; Lee, Seung Won; Chang, Wonpyo; Ha, Kwiseok [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-10-15

    Unprotected Transient Over Power, (UTOP), Unprotected Loss Of Flow (ULOF), and Unprotected Loss Of Heat Sink (ULOHS) are selected as ATWS events. Among these accidents, the ULOF event shows the lowest clad temperature. However, the ULOHS event showed the highest peak clad temperature, due to the positive CRDL/RV expansion reactivity feedback and insufficient DHRS capacity. In this study, the sensitivity tests are conducted. In the case of the UTOP event, a sensitivity test for the reactivity insertion amount and rate were conducted. This analysis can give a requirement for margin of control rod stop system (CRSS). Currently, the reactivity feedback model for the PGSFR is not validated yet. However, the reactivity feedback models in the MARS-LMR are validating with various plant-based data including EBR-II SHRT. The ATWS events for the PGSFR classified in the design extended condition including UTOP, ULOF, and ULOHS are analyzed with MARS-LMR. In this study, the sensitivity tests for reactivity insertion amount and rate in the UTOP event are conducted. The reactivity insertion amount is obviously an influential parameter. The reactivity insertion amount can give a requirement for design of the CRSS, therefore, this sensitivity result is very important to the CRSS. In addition, sensitivity tests for the weighting factor in the radial expansion reactivity model are carried out. The weighting factor for a grid plate, W{sub GP}, which means contribution of feedback in the grid plate is changed for all unprotected events. The grid plate expansion is governed by a core inlet temperature. As the W{sub GP} is increased, the power in the UTOP and the ULOF is increased, however, the power in the ULOHS is decreased. The higher power during transient means lower reactivity feedback and smaller expansion. Thus, the core outlet temperature rise is dominant in the UTOP and ULOF events, however, the core inlet temperature rise is dominant in the ULOHS. Therefore, the grid plate

  9. Preliminary test results in support of integrated EPP and SMT design methods development

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Yanli [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Jetter, Robert I. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Sham, T. -L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-02-09

    The proposed integrated Elastic Perfectly-Plastic (EPP) and Simplified Model Test (SMT) methodology consists of incorporating a SMT data-based approach for creep-fatigue damage evaluation into the EPP methodology to avoid using the creep-fatigue interaction diagram (the D diagram) and to minimize over-conservatism while properly accounting for localized defects and stress risers. To support the implementation of the proposed code rules and to verify their applicability, a series of thermomechanical tests have been initiated. One test concept, the Simplified Model Test (SMT), takes into account the stress and strain redistribution in real structures by including representative follow-up characteristics in the test specimen. The second test concept is the two-bar thermal ratcheting tests with cyclic loading at high temperatures using specimens representing key features of potential component designs. This report summaries the previous SMT results on Alloy 617, SS316H and SS304H and presents the recent development on SMT approach on Alloy 617. These SMT specimen data are also representative of component loading conditions and have been used as part of the verification of the proposed integrated EPP and SMT design methods development. The previous two-bar thermal ratcheting test results on Alloy 617 and SS316H are also summarized and the new results from two bar thermal ratcheting tests on SS316H at a lower temperature range are reported.

  10. Sensitivity of field tests, serological and molecular techniques for Plum Pox Virus detection in various tissues

    Directory of Open Access Journals (Sweden)

    Mojca VIRŠČEK MARN

    2015-12-01

    Full Text Available Sensitivity of field tests (AgriStrip  and Immunochromato, DAS-ELISA, two step RT-PCR and real-time RT-PCR for Plum pox virus (PPV detection was tested in various tissues of apricot, peach, plum and damson plum trees infected with isolates belonging to PPV-D, PPV-M or PPV-Rec, the three strains present in Slovenia. Flowers of apricot and plum in full bloom proved to be a very good source for detection of PPV. PPV could be detected with all tested techniques in symptomatic parts of leaves in May and with one exception even in the beginning of August, but it was not detected in asymptomatic leaves using field tests, DAS-ELISA and partly also molecular techniques. PPV was detected only in some of the samples of asymptomatic parts of the leaves with symptoms and of stalks by field tests and DAS-ELISA. Infections were not detected in buds in August using field tests or DAS-ELISA. Field tests are useful for confirmation of the PPV infection in symptomatic leaves, but in tissues without symptoms DAS-ELISA should be combined or replaced by molecular techniques.

  11. The wrist hyperflexion and abduction of the thumb (WHAT) test: a more specific and sensitive test to diagnose de Quervain tenosynovitis than the Eichhoff's Test.

    Science.gov (United States)

    Goubau, J F; Goubau, L; Van Tongel, A; Van Hoonacker, P; Kerckhove, D; Berghs, B

    2014-03-01

    De Quervain's disease has different clinical features. Different tests have been described in the past, the most popular test being the Eichhoff's test, often wrongly named as the Finkelstein's test. Over the years, a misinterpretation has occurred between these two tests, the latter being confused with the first. To compare the Eichhoff's test with a new test, the wrist hyperflexion and abduction of the thumb test, we set up a prospective study over a period of three years for a cohort of 100 patients (88 women, 12 men) presenting spontaneous pain over the radial side of the styloid of the radius (de Quervain tendinopathy). The purpose of the study was to compare the accuracy of the Eichhoff's test and wrist hyperflexion and abduction of the thumb test to diagnose correctly de Quervain's disease by comparing clinical findings using those tests with the results on ultrasound. The wrist hyperflexion and abduction of the thumb test revealed greater sensitivity (0.99) and an improved specificity (0.29) together with a slightly better positive predictive value (0.95) and an improved negative predictive value (0.67). Moreover, the study showed us that the wrist hyperflexion and abduction of the thumb test is very valuable in diagnosing dynamic instability after successful decompression of the first extensor compartment. Our results support that the wrist hyperflexion and abduction of the thumb test is a more precise tool for the diagnosis of de Quervain's disease than the Eichhoff's test and thus could be adopted to guide clinical diagnosis in the early stages of de Quervain's tendinopathy.

  12. GA(2)LEN skin test study II: clinical relevance of inhalant allergen sensitizations in Europe

    DEFF Research Database (Denmark)

    Burbach, G J; Heinzerling, L M; Edenharter, G

    2009-01-01

    BACKGROUND: Skin prick testing is the standard for diagnosing IgE-mediated allergies. A positive skin prick reaction, however, does not always correlate with clinical symptoms. A large database from a Global Asthma and Allergy European Network (GA(2)LEN) study with data on clinical relevance...... was used to determine the clinical relevance of sensitizations against the 18 most frequent inhalant allergens in Europe. The study population consisted of patients referred to one of the 17 allergy centres in 14 European countries (n = 3034, median age = 33 years). The aim of the study was to assess...... the clinical relevance of positive skin prick test reactions against inhalant allergens considering the predominating type of symptoms in a pan-European population of patients presenting with suspected allergic disease. METHODS: Clinical relevance of skin prick tests was recorded with regard to patient history...

  13. Sensitivity Test for Benchmark Analysis of EBR-II SHRT-17 using MARS-LMR

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Chiwoong; Ha, Kwiseok [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    This study was conducted as a part of the IAEA Coordinated Research Project (CRP), 'Benchmark Analyses of an EBR-II Shutdown Heat Removal Test (SHRT)'. EBR-II SHRT 17 (Loss of flow) was analyzed with MARS-LMR, which is a safety analysis code for a Prototype GEN-IV Sodium-cooled Fast Reactor (PGSFR) has developed in KAERI. The current stage of the CRP is comparing blind test results with opened experimental data. Some influential parameters are selected for the sensitivity test of the EBR-II SHRT-17. The major goal of this study is to understand the behaviors of physical parameters and to make the modeling strategy for better estimation.

  14. Sensitivity testing practice on pre-processing parameters in hard and soft coupled modeling

    Directory of Open Access Journals (Sweden)

    Z. Ignaszak

    2010-01-01

    Full Text Available This paper pays attention to the problem of practical applicability of coupled modeling with the use of hard and soft models types and necessity of adapted to that models data base possession. The data base tests results for cylindrical 30 mm diameter casting made of AlSi7Mg alloy were presented. In simulation tests that were applied the Calcosoft system with CAFE (Cellular Automaton Finite Element module. This module which belongs to „multiphysics” models enables structure prediction of complete casting with division of columnar and equiaxed crystals zones of -phase. Sensitivity tests of coupled model on the particular values parameters changing were made. On these basis it was determined the relations of CET (columnar-to-equaiaxed transition zone position influence. The example of virtual structure validation based on real structure with CET zone location and grain size was shown.

  15. Evaluation of photopatch test allergens for Indian patients of photodermatitis: Preliminary results

    Directory of Open Access Journals (Sweden)

    Nidhi Jindal

    2011-01-01

    Full Text Available Background: There is a strong need to develop a photopatch test tray suitable for Indian patients of photodermatitis as European/Scandinavian photopatch test trays may not be wholly relevant for them. Aim: We carried out this study using photoallergens relevant in the Indian context to determine their relevance in patients of photodermatitis. Methods: Thirty patients (M:F, 23:7 between 19 and 76 years of age of photodermatitis and 10 controls were patch- and photopatch tested with 20 common photoallergens. In addition, the patients were also (photo patch tested with articles of daily use as and when these were suspected to be the cause. Results: Forty-three positive reactions to one or more antigens were seen in 22 (74% patients. Fourteen positive photopatch tests to seven allergens were observed in 10 (33% patients, and nine (30% of them had a definite relevance. The most common contact allergen was fragrance mix (FM (30%, followed by p-phenylenediamine (20% and Parthenium hysterophorous (17%. The definite relevance of the patch- and photopatch tests could be correlated in 47% of these patients. Conclusions: FM is the most common contact and photocontact allergen among the various photopatch test antigens. Although differences in technique and evaluation make direct comparison between different centers difficult, still photopatch testing remains an integral part and gold standard for the work-up of the photosensitive patients.

  16. A Preliminary Analysis of the Linguistic Complexity of Numeracy Skills Test Items for Pre Service Teachers

    Science.gov (United States)

    O'Keeffe, Lisa

    2016-01-01

    Language is frequently discussed as barrier to mathematics word problems. Hence this paper presents the initial findings of a linguistic analysis of numeracy skills test sample items. The theoretical perspective of multi-modal text analysis underpinned this study, in which data was extracted from the ten sample numeracy test items released by the…

  17. Radiation induced chemotherapy sensitization in trimodality therapy of stage 3 non small cell lung cancer. A preliminary report

    Energy Technology Data Exchange (ETDEWEB)

    Takita, H. [Millard Fillmore Hospital, Buffalo (United States); Shin, K. H. [CCS Oncology Center, Kenmore, NY, (United States)

    2000-12-01

    The overall cure rate of locally advanced non-small cell lung carcinoma (NSCLC) remains poor. Although there have been encouraging reports of preoperative use of chemotherapy, more recent trend is the trimodal approach of radiation, chemo, and surgical-therapies. With the trimodal therapy, increased tumor response and resectability are reported, however, there are increased treatment related side effects. It was observed that a relatively small dose of radiation given prior to induction chemotherapy greatly enhanced the tumor response to the chemotherapy without increased toxicity. A total of 18 patients (8 3. A and 10 3.B) were initially given 20 Gy of radiation therapy in 10 fractions and then received 2 courses of Taxol combination chemotherapy. The overall response rate was 83% (15/18) and 13 out of 18 patients underwent surgery. There was one postoperative death (not therapy related). It is speculated that the small dose of radiation therapy may have sensitized the tumor to subsequent chemotherapy, and it was suggested a new hypothesis of radiation therapy induced chemotherapy sensitization.

  18. Construction of PREMUX and preliminary experimental results, as preparation for the HCPB breeder unit mock-up testing

    Energy Technology Data Exchange (ETDEWEB)

    Hernández, F., E-mail: francisco.hernandez@kit.edu [Karlsruhe Institute of Technology (KIT), Institute for Neutron Physics and Reactor Technology (INR) (Germany); Kolb, M. [Karlsruhe Institute of Technology (KIT), Institute for Applied Materials (IAM-WPT) (Germany); Annabattula, R. [Indian Institute of Technology Madras (IITM), Department of Mechanical Engineering (India); Weth, A. von der [Karlsruhe Institute of Technology (KIT), Institute for Neutron Physics and Reactor Technology (INR) (Germany)

    2014-10-15

    Highlights: • PREMUX has been constructed as preparation for a future out-of-pile thermo-mechanical qualification of a HCPB breeder unit mock-up. • The rationale and constructive details of PREMUX are reported in this paper. • PREMUX serves as a test rig for the new heater system developed for the HCPB-BU mock-up. • PREMUX will be used as benchmark for the thermal and thermo-mechanical models developed in ANSYS for the pebble beds of the HCPB-BU. • Preliminary results show the functionality of PREMUX and the good agreement of the measured temperatures with the thermal model developed in ANSYS. - Abstract: One of the European blanket designs for ITER is the Helium Cooled Pebble Bed (HCPB) blanket. The core of the HCPB-TBM consists of so-called breeder units (BUs), which encloses beryllium as neutron multiplier and lithium orthosilicate (Li{sub 4}SiO{sub 4}) as tritium breeder in form of pebble beds. After the design phase of the HCPB-BU, a non-nuclear thermal and thermo-mechanical qualification program for this device is running at the Karlsruhe Institute of Technology. Before the complex full scale BU testing, a pre-test mock-up experiment (PREMUX) has been constructed, which consists of a slice of the BU containing the Li{sub 4}SiO{sub 4} pebble bed. PREMUX is going to be operated under highly ITER-relevant conditions and has the following goals: (1) as a testing rig of new heater concept based on a matrix of wire heaters, (2) as benchmark for the existing finite element method (FEM) codes used for the thermo-mechanical assessment of the Li{sub 4}SiO{sub 4} pebble bed, and (3) in situ measurement of thermal conductivity of the Li{sub 4}SiO{sub 4} pebble bed during the tests. This paper describes the construction of PREMUX, its rationale and the experimental campaign planned with the device. Preliminary results testing the algorithm used for the temperature reconstruction of the pebble bed are reported and compared qualitatively with first analyses

  19. Field Test Report: Preliminary Aquifer Test Characterization Results for Well 299-W15-225: Supporting Phase I of the 200-ZP-1 Groundwater Operable Unit Remedial Design

    Energy Technology Data Exchange (ETDEWEB)

    Spane, Frank A.; Newcomer, Darrell R.

    2009-09-23

    This report examines the hydrologic test results for both local vertical profile characterization and large-scale hydrologic tests associated with a new extraction well (well 299-W15-225) that was constructed during FY2009 for inclusion within the future 200-West Area Groundwater Treatment System that is scheduled to go on-line at the end of FY2011. To facilitate the analysis of the large-scale hydrologic test performed at newly constructed extraction well 299-W15-225 (C7017; also referred to as EW-1 in some planning documents), the existing 200-ZP-1 interim pump-and-treat system was completely shut-down ~1 month before the performance of the large-scale hydrologic test. Specifically, this report 1) applies recently developed methods for removing barometric pressure fluctuations from well water-level measurements to enhance the detection of hydrologic test and pump-and-treat system effects at selected monitor wells, 2) analyzes the barometric-corrected well water-level responses for a preliminary determination of large-scale hydraulic properties, and 3) provides an assessment of the vertical distribution of hydraulic conductivity in the vicinity of newly constructed extraction well 299-W15-225. The hydrologic characterization approach presented in this report is expected to have universal application for meeting the characterization needs at other remedial action sites located within unconfined and confined aquifer systems.

  20. Gaseous electron multiplier-based soft x-ray plasma diagnostics development: Preliminary tests at ASDEX Upgrade

    Science.gov (United States)

    Chernyshova, M.; Malinowski, K.; Czarski, T.; Wojeński, A.; Vezinet, D.; Poźniak, K. T.; Kasprowicz, G.; Mazon, D.; Jardin, A.; Herrmann, A.; Kowalska-Strzeciwilk, E.; Krawczyk, R.; Kolasiński, P.; Zabołotny, W.; Zienkiewicz, P.

    2016-11-01

    A Gaseous Electron Multiplier (GEM)-based detector is being developed for soft X-ray diagnostics on tokamaks. Its main goal is to facilitate transport studies of impurities like tungsten. Such studies are very relevant to ITER, where the excessive accumulation of impurities in the plasma core should be avoided. This contribution provides details of the preliminary tests at ASDEX Upgrade (AUG) with a focus on the most important aspects for detector operation in harsh radiation environment. It was shown that both spatially and spectrally resolved data could be collected, in a reasonable agreement with other AUG diagnostics. Contributions to the GEM signal include also hard X-rays, gammas, and neutrons. First simulations of the effect of high-energy photons have helped understanding these contributions.

  1. PHOEBUS/UHTREX: a preliminary study of a low-cost facility for transient tests of LMFBR fuel

    Energy Technology Data Exchange (ETDEWEB)

    Kirk, W.L. (comp.)

    1976-08-01

    The results of a brief preliminary design study of a facility for transient nuclear tests of fast breeder reactor fuel are described. The study is based on the use of a reactor building originally built for the UHTREX reactor, and the use of some reactor hardware and reactor design and fabrication technology remaining from the Phoebus-2 reactor of the Rover nulcear rocket propulsion program. The facility is therefore currently identified as the PHOEBUS/UHTREX facility. This facility is believed capable of providing early information regarding fast reactor core accident energetics issues which will be very valuable to the overall LMFBR safety program. Facility performance in conjunction with a reference 127-fuel pin experiment is described. Low cost and early availability of the facility were emphasized in the selection of design features and parameters.

  2. Design and preliminary test results of the 40 MW power supply at the National High Magnetic Field Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Boenig, H.J. [Los Alamos National Lab., NM (United States); Bogdan, F.; Morris, G.C. [ABB Drives Inc., New Berlin, WI (United States); Ferner, J.A.; Schneider-Muntau, H.J. [National High Magnetic Field Lab., Tallahassee, FL (United States); Rumrill, R.H.; Rumrill, R.S. [Alpha Scientific Electronics Inc., Hayward, CA (United States)

    1993-11-01

    Four highly stabilized, steady-state, 10 MW power supplies have been installed at the National High Magnetic Field Laboratory in Tallahassee, FL. Each supply consists of a 12.5 kV vacuum circuit breaker, two three-winding, step-down transformers, a 24-pulse rectifier with interphase reactors and freewheeling diodes, and a passive and an active filter. Two different transformer tap settings allow dc supply output voltages of 400 and 500 V. The rated current of a supply is 17 kA and each supply has a one hour overload capability of 20 kA. The power supply output bus system, including a reversing switch at the input and 2 {times} 16 disconnect switches at the output, connects each supply to 16 different magnet cells. The design of the power supply is described and preliminary test results with a supply feeding a 10 MW resistive load are presented.

  3. Gaseous electron multiplier-based soft x-ray plasma diagnostics development: Preliminary tests at ASDEX Upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Chernyshova, M., E-mail: maryna.chernyshova@ipplm.pl; Malinowski, K.; Czarski, T.; Kowalska-Strzęciwilk, E. [Institute of Plasma Physics and Laser Microfusion, Hery 23, 01-497 Warsaw (Poland); Wojeński, A.; Poźniak, K. T.; Kasprowicz, G.; Krawczyk, R.; Kolasiński, P.; Zabołotny, W.; Zienkiewicz, P. [Institute of Electronic Systems, Warsaw University of Technology, Nowowiejska 15/19, 00-665 Warsaw (Poland); Vezinet, D.; Herrmann, A. [Max Planck Institute for Plasma Physics, Boltzmannstr. 2, 85748 Garching (Germany); Mazon, D.; Jardin, A. [CEA, IRFM, F-13108 Saint-Paul-lez-Durance (France)

    2016-11-15

    A Gaseous Electron Multiplier (GEM)-based detector is being developed for soft X-ray diagnostics on tokamaks. Its main goal is to facilitate transport studies of impurities like tungsten. Such studies are very relevant to ITER, where the excessive accumulation of impurities in the plasma core should be avoided. This contribution provides details of the preliminary tests at ASDEX Upgrade (AUG) with a focus on the most important aspects for detector operation in harsh radiation environment. It was shown that both spatially and spectrally resolved data could be collected, in a reasonable agreement with other AUG diagnostics. Contributions to the GEM signal include also hard X-rays, gammas, and neutrons. First simulations of the effect of high-energy photons have helped understanding these contributions.

  4. Testing the Climate Sensitivity of Mountain Hemlock (Tsuga mertensiana (Bong.) Carr.) Near the Southern Limit of Its Range

    Science.gov (United States)

    Appleton, S.; St George, S.

    2014-12-01

    This study investigates the climate sensitivity of mountain hemlock (Tsuga mertensiana (Bong.) Carr.) near the southern limit of its range, tests the stability of its climate-tree relations over the last few decades, and explores its potential as a hydroclimatic proxy for Crater Lake National Park. We collected tree cores at seven locations around the caldera rim, focusing on hemlock growing at higher elevations (2000-2400 masl). The median length of all ring-width series is 283 years, and the oldest hemlock sample extends back to C.E. 1450. Several types of anatomical anomalies, including frost rings, traumatic resin ducts, false rings, and light late-wood bands were observed within the specimens, the most common feature being a false ring in C.E. 1810. Each set of standardized ring-width measurements has a strong common signal, with between-tree correlations (r-bar) ranging from 0.31 to 0.49. Preliminary analysis suggests hemlock growth across the park is strongly and inversely related to total cool-season precipitation, and is also influenced positively (albeit more weakly) by mean summer temperature. Most sites are significantly and negatively correlated with total December-to-February precipitation (r = -0.41) and total precipitation from December to August (r = -0.48). Compared to other ring-width records exhibiting similar negative responses to winter precipitation, these hemlocks appear to track that specific signal quite clearly and, as a result, these data may be suitable to reconstruct past changes in cool-season moisture in Crater Lake National Park and across the broader southern Cascades.

  5. Successful micronucleus testing with the EPI/001 3D reconstructed epidermis model: preliminary findings.

    Science.gov (United States)

    Andres, E; Molinari, J; Remoué, N; Sá-Rocha, V M; Barrichello, C; Hurtado, S P

    2012-03-18

    Currently, the cosmetics industry relies on the results of in vitro genotoxicity tests to assess the safety of chemicals. Although the cytokinesis-block micronucleus (CBMN) test for the detection of cells that have divided once is routinely used and currently accepted by regulatory agencies, it has some limitations. Reconstituted human epidermis (RHE) is widely used in safety assessments because its physiological properties resemble those of the skin, and because it allows testing of substances such as hydrophobic compounds. Thus, the micronucleus test is being adapted for application in RHE-reconstructed tissues. Here we investigated whether two different reconstructed epidermis models (EPI/001 from Straticell, and RHE/S/17 from Skinethic) are suitable for application of the micronucleus test. We found that acetone does not modify micronucleus frequency, cell viability, and model structure, compared with non-treated RHE. Treatment of the EPI/001 model with mitomycin C and vinblastine resulted in a dose-dependent increase of micronucleus frequency as well as a decrease of tissue viability and of binucleated cell rate, while no changes of the epidermal structure were observed. The number of binucleated cells obtained with the RHE/S/17 model was too small to permit micronucleus testing. These results indicate that the proliferative rate of the tissue used is a critical parameter in performing the micronucleus test on a 3D model.

  6. Efficient preliminary floating offshore wind turbine design and testing methodologies and application to a concrete spar design.

    Science.gov (United States)

    Matha, Denis; Sandner, Frank; Molins, Climent; Campos, Alexis; Cheng, Po Wen

    2015-02-28

    The current key challenge in the floating offshore wind turbine industry and research is on designing economic floating systems that can compete with fixed-bottom offshore turbines in terms of levelized cost of energy. The preliminary platform design, as well as early experimental design assessments, are critical elements in the overall design process. In this contribution, a brief review of current floating offshore wind turbine platform pre-design and scaled testing methodologies is provided, with a focus on their ability to accommodate the coupled dynamic behaviour of floating offshore wind systems. The exemplary design and testing methodology for a monolithic concrete spar platform as performed within the European KIC AFOSP project is presented. Results from the experimental tests compared to numerical simulations are presented and analysed and show very good agreement for relevant basic dynamic platform properties. Extreme and fatigue loads and cost analysis of the AFOSP system confirm the viability of the presented design process. In summary, the exemplary application of the reduced design and testing methodology for AFOSP confirms that it represents a viable procedure during pre-design of floating offshore wind turbine platforms.

  7. Resazurin metabolism assay is a new sensitive alternative test in isolated pig cornea.

    Science.gov (United States)

    Perrot, Sébastien; Dutertre-Catella, Hélène; Martin, Chantal; Rat, Patrice; Warnet, Jean-Michel

    2003-03-01

    The main object of our study was to investigate whether the resazurin metabolism assay is a sensitive surfactant and alcohol toxicity test in isolated pig cornea and to compare this recently developed fluorometric assay with the data collected in the eye irritation reference chemical data bank. Resazurin is a substrate that changes color in response to metabolic activity. Isolated pig corneas were immersed for 10 min in surfactants and alcohol irritant solutions. After incubation, resorufin fluorescence was read and corneal viability was assessed. This corneal viability was compared with the maximal modified average score published in the report of ECETOC. This assay highlighted different concentration-dependent irritation potentials of the three surfactants tested, and the same results were obtained with corneas treated with the alcohols. We observed that the degree of surfactant- and alcohol-induced decrease in corneal viability, using the resazurin reduction test, was correlated with the in vivo irritancy measurements as determined by the Draize test and scored with the Modified Maximum Average Score (MMAS). This assay allowed us to classify the ocular irritancy of the tested surfactants and alcohols in the same ranking order as the Draize classification. Corneal viability measurement can be used as a potential alternative for the toxicological assessment of surfactants and alcohols. The nontoxic, nonradioactive resazurin metabolism assay allows rapid assessment of many samples with simple equipment and at reduced cost for continuous monitoring of corneal viability. This assay seems to be suitable as a toxicological screening test for eye irritation determination.

  8. Sensitivity of the speed evaluation tests of carrying the ball in youth soccer players

    Directory of Open Access Journals (Sweden)

    Rakojević Bojan

    2016-01-01

    Full Text Available This research is aimed at examining sensitivity of the speed evaluation tests while carrying the ball. The research included 76 male examinees, aged 17 years (+/- 6 months, who were divided into two qualitatively different subgroups. For determining the speed while carrying the ball, the tests of M type of carrying the ball between cones and slalom ball carrying with a pass were performed. The obtained results proved that the examinees from the group of more successful soccer players (Group 1 scored better on the applied tests when compared to the results of the group consisting of the soccer players from lower ranked clubs and who are not national team members (Group 2. High values of the result homogeneity in the two groups (for the Groups 1 and 2 it was 75% and 68.75% respectively lead to the conclusion that this ability is essential characteristics of young soccer players. The coefficient of discrimination of 0.269 for the results of M type test and 0.197 for the results of the test of carrying the ball with a pass indicate that the results of the two tests provide possibility to qualitatively distinguish youth players. Therefore, it can be concluded that as a technical element, carrying the ball significantly affects the quality of players' performance.

  9. First Total Reflection X-Ray Fluorescence round-robin test of water samples: Preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Borgese, Laura; Bilo, Fabjola [Chemistry for Technologies Laboratory, University of Brescia, Brescia (Italy); Tsuji, Kouichi [Graduate School of Engineering, Osaka City University, Osaka (Japan); Fernández-Ruiz, Ramón [Servicio Interdepartamental de Investigación (SIdI), Laboratorio de TXRF, Universidad Autónoma de Madrid, Madrid (Spain); Margui, Eva [Department of Chemistry, University of Girona, Girona (Spain); Streli, Christina [TU Wien, Atominstitut,Radiation Physics, Vienna (Austria); Pepponi, Giancarlo [Fondazione Bruno Kessler, Povo, Trento (Italy); Stosnach, Hagen [Bruker Nano GmbH, Berlin (Germany); Yamada, Takashi [Rigaku Corporation, Takatsuki, Osaka (Japan); Vandenabeele, Peter [Department of Archaeology, Ghent University, Ghent (Belgium); Maina, David M.; Gatari, Michael [Institute of Nuclear Science and Technology, University of Nairobi, Nairobi (Kenya); Shepherd, Keith D.; Towett, Erick K. [World Agroforestry Centre (ICRAF), Nairobi (Kenya); Bennun, Leonardo [Laboratorio de Física Aplicada, Departamento de Física, Universidad de Concepción (Chile); Custo, Graciela; Vasquez, Cristina [Gerencia Química, Laboratorio B025, Centro Atómico Constituyentes, San Martín (Argentina); Depero, Laura E., E-mail: laura.depero@unibs.it [Chemistry for Technologies Laboratory, University of Brescia, Brescia (Italy)

    2014-11-01

    Total Reflection X-Ray Fluorescence (TXRF) is a mature technique to evaluate quantitatively the elemental composition of liquid samples deposited on clean and well polished reflectors. In this paper the results of the first worldwide TXRF round-robin test of water samples, involving 18 laboratories in 10 countries are presented and discussed. The test was performed within the framework of the VAMAS project, interlaboratory comparison of TXRF spectroscopy for environmental analysis, whose aim is to develop guidelines and a standard methodology for biological and environmental analysis by means of the TXRF analytical technique. - Highlights: • The discussion of the first worldwide TXRF round-robin test of water samples (18 laboratories of 10 countries) is reported. • Drinking, waste, and desalinated water samples were tested. • Data dispersion sources were identified: sample concentration, preparation, fitting procedure, and quantification. • The protocol for TXRF analysis of drinking water is proposed.

  10. Uniaxial strength testing of Calico Hills tuff, Yucca Mountain: Preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Li, Qizhi; Schultz, R.A. [Univ. of Nevada, Reno, NV (United States)

    1994-12-31

    A detailed investigation of the strength properties of Calico Hills tuff was undertaken to further characterize the behavior of this unit. Uniaxial compression test on 47 samples of massive and reworked tuff show a dependence of peak strength and Young`s modulus on the total porosity, and thus on the geologic history of the Calico Hills tuff. Controlled deformation of test specimens documents axial splitting and faulting as failure mechanisms in the post-peak region of these brittle tuffs.

  11. Factors associated with medical student test anxiety in objective structured clinical examinations: a preliminary study

    Science.gov (United States)

    2016-01-01

    Objectives To investigate attributes of medical students associated with their test anxiety on Objective Structured Clinical Examinations (OSCEs). Methods A cross-sectional study using a self-administered questionnaire was conducted of all Year 3 and 4 students at a private medical school in South Korea in 2014. This 53-item questionnaire consisted of factors pertaining to test anxiety on the OSCE identified from a review of relevant literature, which included students’ motivational beliefs and achievement emotions, perceived values of the OSCE, and attitude and orientation towards patients. Participants’ test anxiety levels were measured using the Korean Achievement Emotions Questionnaire. Participants rated their responses using a five-point Likert-type scale. Univariate analysis was performed to examine relationships between the variables. Results A total of 94 students completed the questionnaire (a 93% response rate). No differences in the participants’ test anxiety scores were observed across genders, entry-levels, or years in medical school. Participants’ test anxiety on the OSCE showed moderate association with their class-related achievement emotions (i.e., anxiety and boredom), where r = 0.46 and 0.32, p OSCE (r = -0.21, p OSCE. These findings have implications for developing effective educational interventions for helping students cope with such a stress by enhancing our understanding of the various factors that influence their test anxiety in OSCEs. PMID:28035056

  12. Factors associated with medical student test anxiety in objective structured clinical examinations: a preliminary study.

    Science.gov (United States)

    Kim, Kyong-Jee

    2016-12-29

    To investigate attributes of medical students associated with their test anxiety on Objective Structured Clinical Examinations (OSCEs). A cross-sectional study using a self-administered questionnaire was conducted of all Year 3 and 4 students at a private medical school in South Korea in 2014. This 53-item questionnaire consisted of factors pertaining to test anxiety on the OSCE identified from a review of relevant literature, which included students' motivational beliefs and achievement emotions, perceived values of the OSCE, and attitude and orientation towards patients. Participants' test anxiety levels were measured using the Korean Achievement Emotions Questionnaire. Participants rated their responses using a five-point Likert-type scale. Univariate analysis was performed to examine relationships between the variables. A total of 94 students completed the questionnaire (a 93% response rate). No differences in the participants' test anxiety scores were observed across genders, entry-levels, or years in medical school. Participants' test anxiety on the OSCE showed moderate association with their class-related achievement emotions (i.e., anxiety and boredom), where r = 0.46 and 0.32, p anxiety on the OSCE. These findings have implications for developing effective educational interventions for helping students cope with such a stress by enhancing our understanding of the various factors that influence their test anxiety in OSCEs.

  13. Purification, crystallization and preliminary crystallographic analysis of Est25: a ketoprofen-specific hormone-sensitive lipase

    Energy Technology Data Exchange (ETDEWEB)

    Kim, SeungBum [Department of Biological and Molecular Engineering, College of Engineering, Ajou University, Suwon (Korea, Republic of); Joo, Sangbum [Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon (Korea, Republic of); Yoon, Hyun C.; Ryu, Yeonwoo [Department of Biological and Molecular Engineering, College of Engineering, Ajou University, Suwon (Korea, Republic of); Kim, Kyeong Kyu, E-mail: kkim@med.skku.ac.kr [Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon (Korea, Republic of); Kim, T. Doohun, E-mail: kkim@med.skku.ac.kr [Department of Biological and Molecular Engineering, College of Engineering, Ajou University, Suwon (Korea, Republic of)

    2007-07-01

    Est25, a ketoprofen-specific hormone-sensitive lipase from a metagenomic library, was crystallized and diffraction data were collected to 1.49 Å resolution. Ketoprofen, a nonsteroidal anti-inflammatory drug, inhibits the synthesis of prostaglandin. A novel hydrolase (Est25) with high ketoprofen specificity has previously been identified using a metagenomic library from environmental samples. Recombinant Est25 protein with a histidine tag at the N-terminus was expressed in Escherichia coli and purified in a homogenous form. Est25 was crystallized from 2.4 M sodium malonate pH 7.0 and X-ray diffraction data were collected to 1.49 Å using synchrotron radiation. The crystals belong to the monoclinic space group C2, with unit-cell parameters a = 197.8, b = 95.2, c = 99.4 Å, β = 97.1°.

  14. Sandia National Laboratories Small-Scale Sensitivity Testing (SSST) Report: Calcium Nitrate Mixtures with Various Fuels.

    Energy Technology Data Exchange (ETDEWEB)

    Phillips, Jason Joe [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

    2014-07-01

    Based upon the presented sensitivity data for the examined calcium nitrate mixtures using sugar and sawdust, contact handling/mixing of these materials does not present hazards greater than those occurring during handling of dry PETN powder. The aluminized calcium nitrate mixtures present a known ESD fire hazard due to the fine aluminum powder fuel. These mixtures may yet present an ESD explosion hazard, though this has not been investigated at this time. The detonability of these mixtures will be investigated during Phase III testing.

  15. Engineering, Manufacture and Preliminary Testing of the ITER Toroidal Field (TF) Magnet Helium Cold Circulator

    Science.gov (United States)

    Rista, P. E. C.; Shull, J.; Sargent, S.

    2015-12-01

    The ITER cryodistribution system provides the supercritical Helium (SHe) forced flow cooling to the magnet system using cold circulators. The cold circulators are located in each of five separate auxiliary cold boxes planned for use in the facility. Barber-Nichols Inc. has been awarded a contract from ITER-India for engineering, manufacture and testing of the Toroidal Field (TF) Magnet Helium Cold Circulator. The cold circulator will be extensively tested at Barber-Nichols’ facility prior to delivery for qualification testing at the Japan Atomic Energy Agency's (JAEA) test facility at Naka, Japan. The TF Cold Circulator integrates features and technical requirements which Barber-Nichols has utilized when supplying helium cold circulators worldwide over a period of 35 years. Features include a vacuum-jacketed hermetically sealed design with a very low helium leak rate, a heat shield for use with both nitrogen & helium cold sources, a broad operating range with a guaranteed isentropic efficiency over 70%, and impeller design features for high efficiency. The cold circulator will be designed to meet MTBM of 17,500 hours and MTBF of 36,000 hours. Vibration and speed monitoring are integrated into a compact package on the rotating assembly with operation and health monitoring in a multi-drop PROFIBUS communication environment using an electrical cabinet with critical features and full local and network PLC interface and control. For the testing in Japan and eventual installation in Europe, the cold circulator must be certified to the Japanese High Pressure Gas Safety Act (JHPGSA) and CE marked in compliance with the European Pressure Equipment Directive (PED) including Essential Safety Requirements (ESR). The test methodology utilized at Barber-Nichols’ facility and the resulting test data, validating the high efficiency of the TF Cold Circulator across a broad operating range, are important features of this paper.

  16. Preliminary performance assessment for the Waste Isolation Pilot Plant, December 1992. Volume 5, Uncertainty and sensitivity analyses of gas and brine migration for undisturbed performance

    Energy Technology Data Exchange (ETDEWEB)

    1993-08-01

    Before disposing of transuranic radioactive waste in the Waste Isolation Pilot Plant (WIPP), the United States Department of Energy (DOE) must evaluate compliance with applicable long-term regulations of the United States Environmental Protection Agency (EPA). Sandia National Laboratories is conducting iterative performance assessments (PAs) of the WIPP for the DOE to provide interim guidance while preparing for a final compliance evaluation. This volume of the 1992 PA contains results of uncertainty and sensitivity analyses with respect to migration of gas and brine from the undisturbed repository. Additional information about the 1992 PA is provided in other volumes. Volume 1 contains an overview of WIPP PA and results of a preliminary comparison with 40 CFR 191, Subpart B. Volume 2 describes the technical basis for the performance assessment, including descriptions of the linked computational models used in the Monte Carlo analyses. Volume 3 contains the reference data base and values for input parameters used in consequence and probability modeling. Volume 4 contains uncertainty and sensitivity analyses with respect to the EPA`s Environmental Standards for the Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes (40 CFR 191, Subpart B). Finally, guidance derived from the entire 1992 PA is presented in Volume 6. Results of the 1992 uncertainty and sensitivity analyses indicate that, conditional on the modeling assumptions and the assigned parameter-value distributions, the most important parameters for which uncertainty has the potential to affect gas and brine migration from the undisturbed repository are: initial liquid saturation in the waste, anhydrite permeability, biodegradation-reaction stoichiometry, gas-generation rates for both corrosion and biodegradation under inundated conditions, and the permeability of the long-term shaft seal.

  17. Preliminary Feed Test Algorithm for the Hanford Waste Vitrification Plant product composition control system

    Energy Technology Data Exchange (ETDEWEB)

    Bryan, M.F.; Piepel, G.F.

    1996-03-01

    The Feed Test Algorithm (FTA) will test the acceptability (conformance with requirements) of process batches in the Hanford Waste Vitrification Plant (HWVP). Although requirements and constraints will be imposed on properties of the material in the melter and the resulting glass, the FTA must test acceptability while the batch is still in the Slurry Mix Evaporator (SME), i.e., before material is transferred to the Melter Feed Tank. Hence, some properties upon which requirements will be imposed must be estimated from data available on the feed slurry. The major type of data to be used in this estimation is feed composition, usually expressed in terms of nine oxide mass fractions and a catchall tenth category, Others. Uncertainties are inherent in the HWVP process. The two major or types of uncertainty are composition uncertainty (that related to measurement and estimation of feed composition and other quantities) and model uncertainty (uncertainty inherent in the models developed to relate melt/glass properties to feed composition). Types of uncertainties, representation of uncertainty, and a method for combining uncertainties are discussed. The FTA must account for these uncertainties in testing acceptability; hence it must be statistical in nature. Three types of statistical intervals (confidence, prediction, and tolerance) are defined, and their roles in acceptance testing are discussed.

  18. Autologous serum skin test reactivity and basophil histamine release test in patients with nasal polyposis: preliminary results.

    Science.gov (United States)

    Zambetti, G; Ciofalo, A; Soldo, P; Fusconi, M; Romeo, R; Greco, A; Altissimi, G; Macri, G F; Marinelli, C; Pagliuca, G; De Vincentiis, M

    2010-01-01

    An eosinophilic inflammatory process is generally observed in patients suffering from nasal polyposis (NP), however its onset has not yet been defined. It has been suggested that immune activation of inflammatory cells may be the cause. The aim of this study is to verify whether autoantibodies and/or histamine-releasing factors are present in the serum of patients suffering from NP. In fact, we assume that autoantibodies and/or histamine-releasing factors, as already demonstrated in chronic idiopathic urticaria and asthma, may be involved in the pathogenesis of NP. In this case-control analytical study 40 patients with NP and 27 control subjects underwent the in vivo autologous serum skin test (ASST). The sera from 6 patients suffering from NP and 9 control group subjects, who had all been previously studied and randomly selected, underwent basophil histamine release assay from normal donor as a pilot study. The ASST showed positive results in 55% of patients suffering from NP versus 8% of the control group (p= .00006), the basophil histamine release test (BHRT) turned out positive in all patients tested and in 11% of the control group. We found a weak positive correlation between the percentage of histamine release and the wheal diameter. ASST reactivity is very frequent in patients suffering from NP, thus suggesting the presence of histamine-releasing factors in the blood stream. The BHRT was positive in the serum of all patients, thus suggesting the presence of anti-FcepsilonRI, anti-IgE autoantibodies and/or other histamine-releasing factors, the presence of which can play a role in triggering and maintaining the eosinophilic inflammatory process in NP.

  19. Sensitivity and specificity of the tilt table test in young patients with unexplained syncope.

    Science.gov (United States)

    Fouad, F M; Sitthisook, S; Vanerio, G; Maloney, J; Okabe, M; Jaeger, F; Schluchter, M; Maloney, J D

    1993-03-01

    The usefulness of the head-up tilt testing (HUT) has been previously addressed in diagnosing vasovagal neuroregulatory syncope in the teenage population. However, data concerning sensitivity and specificity is deficient due to the lack of control groups. We compared the response to HUT in young patients referred because of syncope or near syncope (n = 44, mean age 16 +/- 3 years SD) to healthy young volunteers with a normal physical examination and no previous history of syncope (n = 18, mean age 16 +/- 2 years) and to determine the sensitivity and specificity of HUT. The graded tilt protocol was performed at 15 degrees, 30 degrees, and 45 degrees (each for 2 min), and then 60 degrees for 20 minutes. Cuff blood pressure was measured every minute and lead II ECG was continuously monitored. 25 of the 44 patients (57%) developed a vasovagal response or became symptomatic after 13.8 +/- 5.7 minutes of HUT. Three of the 18 volunteers (17%) had a vasovagal response and became symptomatic after 9 +/- 3 minutes of HUT. There was no statistical difference among the four groups (with and without tilt induced vasovagal response) in terms of age and baseline hemodynamic data. The sensitivity of 20 minutes HUT was 57% and its specificity was 83%. The presyncopal hemodynamic response in patients with history of syncope that was characterized by a significant decrease in systolic blood pressure and lack of increase of diastolic blood pressure as compared with baseline and with other groups.(ABSTRACT TRUNCATED AT 250 WORDS)

  20. The Laue diffraction method to search for a neutron EDM. Experimental test of the sensitivity

    Energy Technology Data Exchange (ETDEWEB)

    Fedorov, V.V. E-mail: vfedorov@mail.pnpi.spb.ru; Lapin, E.G.; Lelievre-Berna, E.; Nesvizhevsky, V.V.; Petoukhov, A.K.; Semenikhin, S.Yu.; Soldner, T.; Tasset, F.; Voronin, V.V

    2005-01-01

    The feasibility of an experiment to search for the neutron electric dipole moment (EDM) by Laue diffraction in crystals without a center of symmetry was tested. At the PF1A beam of the ILL reactor a record time delay of {tau}{approx}2 ms for the passage of neutrons through a quartz crystal was reached for the (1 1 0) plane and diffraction angles equal to 88.5 degrees. That corresponds to an effective neutron velocity in the crystal of 20 m/s, while the velocity of the incident neutron was 800 m/s. It was shown experimentally that the value {tau}N{sup 1/2}, determining the method's sensitivity, has a maximum for the Bragg angle equal to 86 deg. The results allow us to estimate the statistical sensitivity of the method for the neutron EDM. For the PF1B beam of the ILL reactor the sensitivity can reach {approx}6x10{sup -25} e cm per day for the available quartz crystal.

  1. A sensitive bacterial-growth-based test reveals how intestinal Bacteroides meet their porphyrin requirement.

    Science.gov (United States)

    Halpern, David; Gruss, Alexandra

    2015-12-29

    Bacteroides sp. are dominant constituents of the human and animal intestinal microbiota require porphyrins (i.e., protoporphyrin IX or iron-charged heme) for normal growth. The highly stimulatory effect of porphyrins on Bacteroides growth lead us to propose their use as a potential determinant of bacterial colonization. However, showing a role for porphryins would require sensitive detection methods that work in complex samples such as feces. We devised a highly sensitive semi-quantitative porphyrin detection method (detection limit 1-4 ng heme or PPIX) that can be used to assay pure or complex biological samples, based on Bacteroides growth stimulation. The test revealed that healthy colonized or non-colonized murine and human hosts provide porphyrins in feces, which stimulate Bacteroides growth. In addition, a common microbiota constituent, Escherichia coli, is shown to be a porphyrin donor, suggesting a novel basis for intestinal bacterial interactions. A highly sensitive method to detect porphyrins based on bacterial growth is devised and is functional in complex biological samples. Host feces, independently of their microbiota, and E. coli, which are present in the intestine, are shown to be porphryin donors. The role of porphyrins as key bioactive molecules can now be assessed for their impact on Bacteroides and other bacterial populations in the gut.

  2. Self-healing mortar with pH-sensitive superabsorbent polymers: testing of the sealing efficiency by water flow tests

    Science.gov (United States)

    Gruyaert, Elke; Debbaut, Brenda; Snoeck, Didier; Díaz, Pilar; Arizo, Alejandro; Tziviloglou, Eirini; Schlangen, Erik; De Belie, Nele

    2016-08-01

    Superabsorbent polymers (SAPs) have potential to be used as healing agent in self-healing concrete due to their property to attract moisture from the environment and their capacity to promote autogenous healing. A possible drawback, however, is their uptake of mixing water during concrete manufacturing, resulting in an increased volume of macro-pores in the hardened concrete. To limit this drawback, newly developed SAPs with a high swelling and pH-sensitiveness were developed and tested within the FP7 project HEALCON. Evaluation of their self-sealing performance occurred through a water permeability test via water flow, a test method also developed within HEALCON. Three different sizes of the newly developed SAP were compared with a commercial SAP. Swelling tests in cement filtrate solution indicated that the commercial and in-house synthesized SAPs performed quite similar, but the difference between the swelling capacity at pH 9 and pH 13 is more pronounced for the self-synthesized SAPs. Moreover, in comparison to the commercial SAPs, less macro-pores are formed in the cement matrix of mixes with self-synthesized SAPs and the effect on the mechanical properties is lower, but not negligible, when using high amounts of SAPs. Although the immediate sealing effect of cracks in mortar was the highest for the commercial SAPs, the in-house made SAPs with a particle size between 400 and 600 μm performed the best with regard to crack closure (mainly CaCO3 precipitation) and self-sealing efficiency, after exposing the specimens to 28 wet-dry cycles. Some specimens could even withstand a water pressure of 2 bar.

  3. Preliminary Design of a Pendulum Experiment for Searching for a Lorentz-Violation Signal

    CERN Document Server

    Shao, Cheng-Gang; Tan, Yu-Jie

    2016-01-01

    This work mainly presents a preliminary design for a pendulum experiment with both the source mass and the test mass in a striped pattern to amplify the Lorentz-violation signal, since the signal is sensitive to edge effects.

  4. PRELIMINARY TEST RESULTS OF A PROTOTYPE FAST KICKER FOR APS MBA UPGRADE

    Energy Technology Data Exchange (ETDEWEB)

    Yao, C.-Y.; Morrison, L.; Sun, X.; Wang, J.; Cours, A.; Westferro, F.; Xiao, A.; Clute, T.; Conway, Z.; Decker, G.; Lenkszus, F.; Carwardine, J.; Barcikowski, A.; Keane, R.; Brill, A.

    2017-06-25

    The APS multi-bend achromatic (MBA) upgrade storage ring plans to support two bunch fill patterns: a 48-bunch and a 324-bunch. A “swap out” injection scheme is required. In order to provide the required kick to injected beam, to minimize the beam loss and residual oscillation of injected beam, and to minimize the perturbation to stored beam during injection, the rise, fall, and flat-top parts of the kicker pulse must be within a 16.9-ns interval. Stripline-type kickers are chosen for both injection and extraction. We developed a prototype kicker that supports a ±15kV differential pulse voltage. We performed high voltage discharge, TDR measurement, high voltage pulse test and beam test of the kicker. We report the final design of the fast kicker and the test results.

  5. Effects of disclosing hypothetical genetic test results for salt sensitivity on salt restriction behavior

    Directory of Open Access Journals (Sweden)

    Takeshima T

    2013-05-01

    Full Text Available Taro Takeshima,1,2 Masanobu Okayama,1 Masanori Harada,3 Ryusuke Ae,4 Eiji Kajii1 1Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University, Tochigi, Japan; 2Department of Healthcare Epidemiology, Kyoto University Graduate School of Medicine and Public Health, Kyoto, Japan; 3Department for Support of Rural Medicine, Yamaguchi Grand Medical Center, Yamaguchi, Japan; 4Department of General Internal Medicine, Hamasaka Public Hospital, Mikata, Japan Background: A few studies have explored the effects of disclosure of genetic testing results on chronic disease predisposition. However, these effects remain unclear in cases of hypertension. Reducing salt intake is an important nonpharmacological intervention for hypertension. We investigated the effects of genetic testing for salt sensitivity on salt restriction behavior using hypothetical genetic testing results. Methods: We conducted a cross-sectional study using a self-completed questionnaire. We enrolled consecutive outpatients who visited primary care clinics and small hospitals between September and December 2009 in Japan. We recorded the patients’ baseline characteristics and data regarding their salt restriction behavior, defined as reducing salt intake before and after disclosure of hypothetical salt sensitivity genetic test results. Behavioral stage was assessed according to the five-stage transtheoretical model. After dividing subjects into salt restriction and no salt restriction groups, we compared their behavioral changes following positive and negative test results and analyzed the association between the respondents’ characteristics and their behavioral changes. Results: We analyzed 1562 participants with a mean age of 58 years. In the no salt restriction group, which included patients at the precontemplation, contemplation, and preparation stages, 58.7% stated that their behavioral stage progressed after a positive test result, although 29

  6. Preliminary laboratory testing on the sound absorption of coupled cavity sonic crystal

    Science.gov (United States)

    Kristiani, R.; Yahya, I.; Harjana; Suparmi

    2016-11-01

    This paper focuses on the sound absorption performance of coupled cavity sonic crystal. It constructed by a pair of a cylindrical tube with different values in diameters. A laboratory test procedure after ASTM E1050 has been conducted to measure the sound absorption of the sonic crystal elements. The test procedures were implemented to a single coupled scatterer and also to a pair of similar structure. The results showed that using the paired structure bring a better possibility for increase the sound absorption to a wider absorption range. It also bring a practical advantage for setting the local Helmholtz resonant frequency to certain intended frequency.

  7. First Total Reflection X-Ray Fluorescence round-robin test of water samples: Preliminary results

    Science.gov (United States)

    Borgese, Laura; Bilo, Fabjola; Tsuji, Kouichi; Fernández-Ruiz, Ramón; Margui, Eva; Streli, Christina; Pepponi, Giancarlo; Stosnach, Hagen; Yamada, Takashi; Vandenabeele, Peter; Maina, David M.; Gatari, Michael; Shepherd, Keith D.; Towett, Erick K.; Bennun, Leonardo; Custo, Graciela; Vasquez, Cristina; Depero, Laura E.

    2014-11-01

    Total Reflection X-Ray Fluorescence (TXRF) is a mature technique to evaluate quantitatively the elemental composition of liquid samples deposited on clean and well polished reflectors. In this paper the results of the first worldwide TXRF round-robin test of water samples, involving 18 laboratories in 10 countries are presented and discussed. The test was performed within the framework of the VAMAS project, interlaboratory comparison of TXRF spectroscopy for environmental analysis, whose aim is to develop guidelines and a standard methodology for biological and environmental analysis by means of the TXRF analytical technique.

  8. The sensitivity and specificity of a diagnostic test of sequence-space synesthesia.

    Science.gov (United States)

    Rothen, Nicolas; Jünemann, Kristin; Mealor, Andy D; Burckhardt, Vera; Ward, Jamie

    2016-12-01

    People with sequence-space synesthesia (SSS) report stable visuo-spatial forms corresponding to numbers, days, and months (amongst others). This type of synesthesia has intrigued scientists for over 130 years but the lack of an agreed upon tool for assessing it has held back research on this phenomenon. The present study builds on previous tests by measuring the consistency of spatial locations that is known to discriminate controls from synesthetes. We document, for the first time, the sensitivity and specificity of such a test and suggest a diagnostic cut-off point for discriminating between the groups based on the area bounded by different placement attempts with the same item.

  9. Sensitization to Aeroallergens in Patients with Respiratory Allergies Based on Skin-Prick Test Results

    Directory of Open Access Journals (Sweden)

    G Bejtullahu

    2012-10-01

    Full Text Available Background: The aim of this study was to identify the most common aeroallergens in patients with asthma and rhinitis.Methods: The study enrolled 102 participants including 64 patients with respiratory allergies (among them 15 were clinically diagnosed as asthma patients, 41 with rhinitis, 8 were both and 38 healthy controls. All of participants were subject of skin prick tests (SPT with series of common allergenic extracts. Sera from all participants were tested for total IgE and eosinophil count. To measure airflow limitation and reversibility in asthma patients the pulmonary function testing were carried out.Results: M/F ratio was 1:1.6 in patients and 1:0.7 in control group with mean age 28.88 year (SD 13.16; range 6 – 55year and 20.47 respectively (SD 1.16; range 19-23 year. The most common risk factors in these patients were total IgE more than 100 IU/ml, eosinophils above 4% and positive family history of atopy. Skin prick testing results showed prevalence rates for allergen groups in this manner: house dust mites 81.3 %, pollens 57.8 %, animal dandruff12.5% and moulds 4.9%. Polysensitization was common in 51.6% of all sensitized patients being positive to more than one group of allergens.Conclusion: House dust mites are the main sensitizing allergens among our allergic patients as well as healthy controls. Next in importance, in all participants, are grasses. This pattern of prevalence was expected based on herbal geography, climate and specially lifestyle. It was also compatible with the results from studies carried out in places with the same habitat.

  10. Relationship between contrast sensitivity test and disease severity in multiple sclerosis patients.

    Science.gov (United States)

    Soler García, A; González Gómez, A; Figueroa-Ortiz, L C; García-Ben, A; García-Campos, J

    2014-09-01

    To assess the importance of the Pelli-Robson contrast sensitivity test in multiple sclerosis patients according to the Expanded Disability Status Scale (EDSS). A total of 62 patients with multiple sclerosis were included in a retrospective study. Patients were enrolled from the Neurology Department to Neuroophthalmology at Virgen de la Victoria Hospital. Patients were classified into 3 groups according to EDSS: group A) lower than 1.5, group B) between 1.5 and 3.5 and group C) greater than 3.5. Visual acuity and monocular and binocular contrast sensitivity were performed with Snellen and Pelli-Robson tests respectively. Twelve disease-free control participants were also recruited. Correlations between parameter changes were analyzed. The mean duration of the disease was 81.54±35.32 months. Monocular and binocular Pelli-Robson mean values in the control group were 1.82±0.10 and 1.93±0.43 respectively, and 1.61±0.29 and 1.83±0.19 in multiple sclerosis patients. There were statistically significant differences in the monocular analysis for a level of significance P<.05. Mean monocular and binocular Pelli-Robson values in relation to gravity level were, in group A: 1.66±0.24 and 1.90±0.98, group B: 1.64±0.21 and 1.82±0.16, and group C: 1.47±0.45 and 1.73±0.32 respectively. Group differences were statistically significant in both tests: P=.05 and P=.027. Monocular and binocular contrast discrimination analyzed using the Pelli-Robson test was found to be significantly lower when the severity level, according EDSS, increases in multiple sclerosis patients. Copyright © 2013 Sociedad Española de Oftalmología. Published by Elsevier Espana. All rights reserved.

  11. High Temperature Test Facility Preliminary RELAP5-3D Input Model Description

    Energy Technology Data Exchange (ETDEWEB)

    Bayless, Paul David [Idaho National Laboratory

    2015-12-01

    A RELAP5-3D input model is being developed for the High Temperature Test Facility at Oregon State University. The current model is described in detail. Further refinements will be made to the model as final as-built drawings are released and when system characterization data are available for benchmarking the input model.

  12. High Temperature Steam Electrolysis Materials Degradation: Preliminary Results of Corrosion Tests on Ceramatec Electrolysis Cell Components

    Energy Technology Data Exchange (ETDEWEB)

    Paul Demkowicz; Prateek Sachdev; Kevin DeWall; Pavel Medvedev

    2007-06-01

    Corrosion tests were performed on stainless steel and nickel alloy coupons in H2O/H2 mixtures and dry air to simulate conditions experienced in high temperature steam electrolysis systems. The stainless steel coupons were tested bare and with one of three different proprietary coatings applied. Specimens were corroded at 850°C for 500 h with weight gain data recorded at periodic intervals. Post-test characterization of the samples included surface and cross-section scanning electron microscopy, grazing incidence x-ray diffraction, and area-specific resistance measurements. The uncoated nickel alloy outperformed the ferritic stainless steel under all test conditions based on weight gain data. Parabolic rate constants for corrosion of these two uncoated alloys were consistent with values presented in the literature under similar conditions. The steel coatings reduced corrosion rates in H2O/H2 mixtures by as much as 50% compared to the untreated steel, but in most cases showed negligible corrosion improvement in air. The use of a rare-earth-based coating on stainless steel did not result in a significantly different area specific resistance values after corrosion compared to the untreated alloy. Characterization of the samples is still in progress and the findings will be revised when the complete data set is available.

  13. Preliminary report on engineering geology of thirteen tunnel sites, Nevada Test Site

    Science.gov (United States)

    Wilmarth, Verl Richard; McKeown, Francis Alexander; Dobrovolny, Ernest

    1958-01-01

    Reconnaissance of 13 areas in and adjacent to Nevada Test Site was completed. Of the 13 areas, Forty Mile Canyon, South-central Shoshone Mountain, and Southeast Shoshone Mountain named in order of preference, offer many advantages for carrying on future underground nuclear explosions.

  14. Roche DAT immunoassay: sensitivity and specificity testing for amphetamines, cocaine, and opiates in oral fluid.

    Science.gov (United States)

    Crooks, C Richard; Brown, Sue

    2010-03-01

    Laboratory testing of oral fluid for drugs of abuse continues to expand in the workplace, legal, treatment, and health settings. In this study, we assessed recently developed homogeneous Roche DAT screening assays for amphetamines, cocaine metabolite [benzoylecgonine (BZE)], methamphetamines, and opiates in oral fluid. Precision and accuracy were assessed using control samples at +/-25% of cutoff. Sensitivity, specificity, and agreement compared to liquid chromatography-tandem mass spectrometry (LC-MS-MS) was assessed by analysis of oral fluid specimens collected from 994 subjects enrolled in a drug treatment or probation and parole drug-testing program. An additional 180 research specimens from Kroll Laboratories were analyzed for amphetamine and methamphetamine. Screening cutoff concentrations (ng/mL) were as follows: amphetamines, 40; cocaine metabolite, 3; methamphetamines, 40; and opiates, 10. LC-MS-MS analyses were performed with the following cutoff concentrations (ng/mL): amphetamine, 40; BZE, 2.0; methamphetamine, 40; and codeine or morphine, 10. The percent coefficient of variation ranged from 3.4% to 7.3%. Sensitivity and specificity of the Roche DAT assays compared to LC-MS-MS were > 94%, and agreement was > 96% for the four assays. The performance of the Roche DAT assays suggests these new homogeneous screening assays will be an attractive alternative to existing more labor-intensive enzyme immunoassays.

  15. ABSTRACT: CONTAMINANT TRAVEL TIMES FROM THE NEVADA TEST SITE TO YUCCA MOUNTAIN: SENSITIVITY TO POROSITY

    Energy Technology Data Exchange (ETDEWEB)

    Karl F. Pohlmann; Jianting Zhu; Jenny B. Chapman; Charles E. Russell; Rosemary W. H. Carroll; David S. Shafer

    2008-09-05

    Yucca Mountain (YM), Nevada, has been proposed by the U.S. Department of Energy as a geologic repository for spent nuclear fuel and high-level radioactive waste. In this study, we investigate the potential for groundwater advective pathways from underground nuclear testing areas on the Nevada Test Site (NTS) to the YM area by estimating the timeframe for advective travel and its uncertainty resulting from porosity value uncertainty for hydrogeologic units (HGUs) in the region. We perform sensitivity analysis to determine the most influential HGUs on advective radionuclide travel times from the NTS to the YM area. Groundwater pathways and advective travel times are obtained using the particle tracking package MODPATH and flow results from the Death Valley Regional Flow System (DVRFS) model by the U.S. Geological Survey. Values and uncertainties of HGU porosities are quantified through evaluation of existing site porosity data and expert professional judgment and are incorporated through Monte Carlo simulations to estimate mean travel times and uncertainties. We base our simulations on two steady state flow scenarios for the purpose of long term prediction and monitoring. The first represents pre-pumping conditions prior to groundwater development in the area in 1912 (the initial stress period of the DVRFS model). The second simulates 1998 pumping (assuming steady state conditions resulting from pumping in the last stress period of the DVRFS model). Considering underground tests in a clustered region around Pahute Mesa on the NTS as initial particle positions, we track these particles forward using MODPATH to identify hydraulically downgradient groundwater discharge zones and to determine which flowpaths will intercept the YM area. Out of the 71 tests in the saturated zone, flowpaths of 23 intercept the YM area under the pre-pumping scenario. For the 1998 pumping scenario, flowpaths from 55 of the 71 tests intercept the YM area. The results illustrate that mean

  16. Contaminant Travel Times From the Nevada Test Site to Yucca Mountain: Sensitivity to Porosity

    Science.gov (United States)

    Pohlmann, K. F.; Zhu, J.; Chapman, J. B.; Russell, C. E.; Carroll, R. W.; Shafer, D. S.

    2008-12-01

    Yucca Mountain (YM), Nevada, has been proposed by the U.S. Department of Energy as a geologic repository for spent nuclear fuel and high-level radioactive waste. In this study, we investigate the potential for groundwater advective pathways from underground nuclear testing areas on the Nevada Test Site (NTS) to the YM area by estimating the time frame for advective travel and its uncertainty resulting from porosity value uncertainty for hydrogeologic units (HGUs) in the region. We perform sensitivity analysis to determine the most influential HGUs on advective radionuclide travel times from the NTS to the YM area. Groundwater pathways and advective travel times are obtained using the particle tracking package MODPATH and flow results from the Death Valley Regional Flow System (DVRFS) model by the U.S. Geological Survey. Values and uncertainties of HGU porosities are quantified through evaluation of existing site porosity data and expert professional judgment and are incorporated through Monte Carlo simulations to estimate mean travel times and uncertainties. We base our simulations on two steady state flow scenarios for the purpose of long term prediction and monitoring. The first represents pre-pumping conditions prior to groundwater development in the area in 1912 (the initial stress period of the DVRFS model). The second simulates 1998 pumping (assuming steady state conditions resulting from pumping in the last stress period of the DVRFS model). Considering underground tests in a clustered region around Pahute Mesa on the NTS as initial particle positions, we track these particles forward using MODPATH to identify hydraulically downgradient groundwater discharge zones and to determine which flowpaths will intercept the YM area. Out of the 71 tests in the saturated zone, flowpaths of 23 intercept the YM area under the pre-pumping scenario. For the 1998 pumping scenario, flowpaths from 55 of the 71 tests intercept the YM area. The results illustrate that mean

  17. SiMa Cells for a Serotype Specific and Sensitive Cell-Based Neutralization Test for Botulinum Toxin A and E

    Directory of Open Access Journals (Sweden)

    Nicola Bak

    2017-07-01

    Full Text Available Botulinum toxins (BoNTs, of which there are seven serotypes, are among the most potent neurotoxins, with serotypes A, B and E causing human botulism. Antitoxins form the first line of treatment for botulism, and functional, highly sensitive in vitro methods for toxin neutralization are needed to replace the current in vivo methods used for determination of antitoxin potency. In this preliminary proof of concept study, we report the development of a neutralization test using the neuroblastoma SiMa cell line. The assay is serotype specific for either BoNT/A or BoNT/E, which both cleave unique sequences on SNAP-25 within SiMa cells. The end point is simple immunodetection of cleaved SNAP-25 from cell lysates with antibodies detecting only the newly exposed sequence on SNAP-25. Neutralizing antibodies prevent the toxin-induced cleavage of SNAP-25. The toxin neutralization assay, with an EC50 of ~2 mIU/mL determined with a standardized reference antiserum, is more sensitive than the mouse bioassays. Relevance was demonstrated with commercial and experimental antitoxins targeting different functional domains, and of known in vivo neutralizing activities. This is the first report describing a simple, specific, in vitro cell-based assay for the detection of neutralizing antibodies against BoNT/A and BoNT/E with a sensitivity exceeding that of the mouse bioassay.

  18. A preliminary neutronic evaluation of high temperature engineering test reactor using the SCALE6 code

    Science.gov (United States)

    Tanure, L. P. A. R.; Sousa, R. V.; Costa, D. F.; Cardoso, F.; Veloso, M. A. F.; Pereira, C.

    2014-02-01

    Neutronic parameters of some fourth generation nuclear reactors have been investigated at the Departamento de Engenharia Nuclear/UFMG. Previous studies show the possibility to increase the transmutation capabilities of these fourth generation systems to achieve significant reduction concerning transuranic elements in spent fuel. To validate the studies, a benchmark on core physics analysis, related to initial testing of the High Temperature Engineering Test Reactor and provided by International Atomic Energy Agency (IAEA) was simulated using the Standardized Computer Analysis for Licensing Evaluation (SCALE). The CSAS6/KENO-VI control sequence and the 44-group ENDF/B-V 0 cross-section neutron library were used to evaluate the keff (effective multiplication factor) and the result presents good agreement with experimental value.

  19. Preliminary results on performance testing of a turbocharged rotary combustion engine

    Science.gov (United States)

    Meng, P. R.; Rice, W. J.; Schock, H. J.; Pringle, D. P.

    1982-01-01

    The performance of a turbocharged rotary engine at power levels above 75 kW (100 hp) was studied. A twin rotor turbocharged Mazda engine was tested at speeds of 3000 to 6000 rpm and boost pressures to 7 psi. The NASA developed combustion diagnostic instrumentation was used to quantify indicated and pumping mean effect pressures, peak pressure, and face to face variability on a cycle by cycle basis. Results of this testing showed that a 5900 rpm a 36 percent increase in power was obtained by operating the engine in the turbocharged configuration. When operating with lean carburetor jets at 105 hp (78.3 kW) and 4000 rpm, a brake specific fuel consumption of 0.45 lbm/lb-hr was measured.

  20. F-111 Adhesively Bonded Repair Assessment Program (FABRAP) - Phase 1 Testing, Preliminary Results

    Science.gov (United States)

    2011-08-01

    UNCLASSIFIED 4 UNCLASSIFED DSTO-TN-1024  aircraft that have been reserved for other use such as museum displays. Negotiations are underway to test...additional hazards when used outside of a fume cupboard/booth. Citrasafe is a non-toxic low volatile plant extract solvent which has been shown to be...work during hayfever seasons may expose workers to pollen allergens. Staff with known allergies will be advised to prepare by using

  1. Mastitis diagnosis in dairy goats through somatic cell counts and California mastitis test. Preliminary results

    OpenAIRE

    Mendonça, Álvaro; Valentim, Ramiro; Nunes, Manuel; Correia, Teresa Montenegro; Trigo, Margarida; Maurício, Raimundo; Costa, Cristina; Coelho, Alípio

    2004-01-01

    The aim of this work was to evaluate somatic cell count (SCC) and Californian mastitis test (CMT) reliability as methods to survey mastitis in Serrana goats. Microbiological diagnosis, SCC and CTM were performed on 2028 samples, collected from individual glands during a lactation period. According to results CMT (predictive negative value = 69.5%) may be used as a cheap and practical method for sub clinical mastitis survey in Serrana goats. Decision on SCC use will depend on additional resear...

  2. [Preliminary Study on Error Control of Medical Devices Test Reports Based on the Analytic Hierarchy Process].

    Science.gov (United States)

    Huang, Yanhong; Xu, Honglei; Tu, Rong; Zhang, Xu; Huang, Min

    2016-01-01

    In this paper, the common errors in medical devices test reports are classified and analyzed. And then the main 11 influence factors for these inspection report errors are summarized. The hierarchy model was also developed and verified by presentation data using MATLAB. The feasibility of comprehensive weights quantitative comparison has been analyzed by using the analytic hierarchy process. In the end, this paper porspects the further research direction.

  3. Preliminary study of Internet addiction and cognitive function in adolescents based on IQ tests.

    Science.gov (United States)

    Park, Min-Hyeon; Park, E-Jin; Choi, Jeewook; Chai, Sukhi; Lee, Ji-Han; Lee, Chul; Kim, Dai-Jin

    2011-12-30

    The potential relationship between Internet addiction and certain cognitive function problems has been suggested by several studies. However, few or no studies have examined the differences in cognitive functioning between persons addicted to the Internet and persons not addicted using a standard neuropsychological test. This study screened 253 middle school students and 389 high school students for Internet addiction and compared 59 Internet-addicted students with 43 non-addicted students using an IQ test. The Internet-addicted group had comprehension sub-item scores that were significantly lower than those of the non-addicted group. As the comprehension item reflects ethical judgement and reality testing, there may be a relationship between Internet addiction and weak social intelligence. Earlier onset of Internet addiction and longer addiction duration were associated with lower participant performance in areas related to attention. As this study is a cross-sectional study, it is not clear whether the persons who display weak cognitive functioning are susceptible to Internet addiction or if Internet addiction causes cognitive problems. However, as brain development remains active during adolescence, the possibility that Internet addiction adversely affects the cognitive functioning of adolescents cannot be ruled out.

  4. Establishment and Preliminary Application of a Rapid Fluorescent Focus Inhibition Test (RFFIT) for Rabies Virus

    Institute of Scientific and Technical Information of China (English)

    Pengcheng Yu; Xinjun Lv; Xinxin Shen; Qing Tang; Guodong Liang

    2013-01-01

    The World Health Organization (WHO) standard assay for determining levels of the rabies virus neutralization antibody (RVNA) is the rapid fluorescent focus inhibition test (RFFIT),which is used to evaluate the immunity effect after vaccination against rabies.For RFFIT,CVS-11 was used as the challenge virus,BSR cells as the adapted cells,and WHO rabies immunoglobulin (WHO STD) as the reference serum in this study.With reference to WHO and Pasteur RFFIT procedures,a micro-RFFIT procedure adapted to our laboratory was produced,and its specificity and reproducibility were tested.We tested levels of RVNA in human serum samples after immunization with different human rabies vaccines (domestic purified Vero cell rabies vaccine (PVRV) and imported purified chick embryo cell vaccine (PCECV)) using different regimens (Zagreb regimen and Essen regimen).We analyzed the levels of RVNA,and compared the immune efficacy of domestic PVRV and imported PCECV using different immunization regimens.The results showed that the immune efficacy of domestic PVRV using the Zagreb regimen was as good as that of the imported PCECV,but virus antibodies were generated more rapidly with the Zagreb regimen than with the Essen regimen.The RFFIT procedure established in our laboratory will enhance the comprehensive detection ability of institutions involved in rabies surveillance in China.

  5. New sonographically-guided test for anterior knee instability – preliminary report

    Directory of Open Access Journals (Sweden)

    Piotr Grzelak

    2014-09-01

    Full Text Available Aim of the study: Ultrasound examination is widely used in orthopedic diagnostics, however sonographic evaluation of traumatic anterior cruciate ligament insufficiency is still inadequate. Aim of this study is to evaluate diagnostic capability of a new sonographicallyguided test for diagnosing complete anterior cruciate ligament insufficiency. Material and methods: In 47 patients, with suspicion of unilateral anterior cruciate ligament injury (based on magnetic resonance imaging, the sonographically-guided test for anterior instability was performed. The translation of the intercondylar eminence against the patellar tendon was measured in both knees. Afterwards all patients underwent arthroscopy. Results: In 37 patients, with arthroscopically confirmed complete anterior cruciate ligament insufficiency, the mean anterior knee translation was 8.3 mm (SD = 2.8 in affected knee vs. 3 mm (SD = 1.1 in uninjured knee (p < 0.001. In 10 patients with no anterior cruciate ligament insufficiency the difference between body sides was not significant (2.6 mm, SD = 1.4 in injured knee vs. 2.5 mm, SD = 1.1 in uninjured joint; p < 0.7753. Conclusions: The proposed test supports the clinician with fast and noninvasive examination that can facilitate evaluation of anterior knee instability.

  6. Sensitization Profile to Allergens in Patients Using Multi-Test II

    Science.gov (United States)

    Maniglia, Sergio Fabricio; Tsuru, Fernanda Miyoko; Santos, Victor Carvalho dos; Ueda, Denis Massatsugu

    2014-01-01

    Introduction Medical intervention in allergies has broadened its perspective, also focusing in the quality of life of patients. Patients are instructed, before using pharmacotherapy agents, to avoid the causal agent. Objective This study aims to analyze the sensitization profile of patients with allergic complaints and identify possible characteristics specific to each age group and gender. Methods A descriptive cross-sectional study included data collected from medical records (from Multi-Test II database, Lincoln Diagnostics Inc. Decatur, Illinois) of 1,912 patients who underwent skin prick test from March to October 2013. Patients were organized and analyzed according to gender, age, and results of the allergens subtypes tested. Results The study was composed of 1,912 patients (60% male and 40% female) of ages between 3 and 87 years. Positive tests were more prevalent in quantity and intensity with the mites Dermatophagoides pteronyssinus and Dermatophagoides farinae, each with 60% of the total analyzed. In second place were pollens, especially Dactylis glomerata and Festuca pratensis. Conclusion The female and male sexes were equally atopic. Fungi and epithelia of dog and cat were not considered potential aeroallergens that could cause symptoms. However, mites are common in Paraná, Brazil. Further studies regarding the pollens are needed, as this study result diverged from the literature. PMID:25992129

  7. An irradiation test of heat-resistant ceramic composite materials. Interim report on post-irradiation examinations of the first preliminary irradiation test: 97M-13A

    Energy Technology Data Exchange (ETDEWEB)

    Baba, Shin-ichi; Takahashi, Tsuneo; Ishihara, Masahiro; Hayashi, Kimio; Sozawa, Shizuo; Saito, Takashi [Japan Atomic Energy Research Inst., Oarai, Ibaraki (Japan). Oarai Research Establishment; Suzuki, Yoshio [Nuclear Engineering, Co. Ltd., Osaka (Japan); Saito, Tamotsu; Sekino, Hajime [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2001-03-01

    The Japan Atomic Energy Research Institute (JAERI) has been carrying out the research on radiation damage mechanism of heat-resistant ceramic composite materials, as one of the subjects of the innovative basic research on high temperature engineering using the High Temperature Engineering Test Reactor (HTTR). A series of preliminary irradiation tests is being made using the Japan Materials Testing Reactor (JMTR). The present report describes results of post-irradiation examinations (PIE) so far on specimens irradiated in the first capsule, designated 97M-13A, to fast neutron fluences of 1.2-1.8x10{sup 24} m{sup -2} (E>1 MeV) at temperatures of 573, 673 and 843 K. In the PIE, measurements were made on (1) dimensional changes, (2) thermal expansions, (3) X-ray parameters and (4) {gamma}-ray spectra. The results for the carbon/carbon and SiC/SiC composites were similar to those in existing literatures. The temperature monitor effect was observed both for SiC fiber- and particle-reinforced SiC composites as in the case of monolithic SiC. Namely, the curve of the coefficient of thermal expansion (CTE) of these specimens showed a rapid drop above a temperature around the irradiation temperature +100 K in the first ramp (ramp rate: 10 K/min), while in the second ramp the CTE curves were almost the same as those of un-irradiated SiC specimens. (author)

  8. Saltatory ontogeny of fishes and sensitive early life stages for ecotoxicology tests.

    Science.gov (United States)

    Belanger, Scott E; Balon, Eugene K; Rawlings, Jane M

    2010-04-15

    Fish display a wide range of developmental ontogenies. These distinctions have taxonomic, evolutionary, and ecological importance in addition to practical implications on the use of fish in aquatic toxicity tests. With respect to animal welfare, vertebrates are afforded protected or non-protected status in the European Union based upon whether they feed endogenously off the yolk or exogenously by procurement and ingestion of food. The concept of saltatory ontogeny suggests development is not gradual but proceeds in leaps separated by a series of stable developmental states. In this context, endogenous/exogenous feeding also distinguishes the developmental phases of embryo (egg), eleutheroembryo (feeding off the yolk sac) and larvae (exogenous feeding) in fish. The recent proposal for the Fish Embryo Test (FET) as an animal alternative to the standard fish acute toxicity test (OECD 203 and equivalent tests) puts a clear focus on the need to identify the non-protected and protected life intervals in test species as well as their sensitivities which coincides with the developmental phases identified in saltatory ontogeny. In this paper we described a method to quantify embryo, eleutheroembryo, and larva phases in Danio rerio, the zebrafish. Danio eleutheroembryos preyed upon 5 different protozoan species (Euglena, Euplotes, Paramecium aurelia, Paramecium bursaria and Paramecium multimicronucleatum) between 24 and 48hr following hatching (85-95% of fish, n=20 per species, 25 degrees C). Based upon these data it is recommended that testing of developing zebrafish embryos should be terminated between 24 and 48hr after hatching in order to be compliant with existing animal welfare legislation within Europe.

  9. The Brief Kinesthesia test is feasible and sensitive: a study in stroke

    Directory of Open Access Journals (Sweden)

    Alexandra Borstad

    2016-02-01

    Full Text Available BACKGROUND: Clinicians lack a quantitative measure of kinesthetic sense, an important contributor to sensorimotor control of the hand and arm. OBJECTIVES: The objective here was to determine the feasibility of administering the Brief Kinesthesia Test (BKT and begin to validate it by 1 reporting BKT scores from persons with chronic stroke and a healthy comparison group and 2 examining the relationship between the BKT scores and other valid sensory and motor measures. METHOD: Adults with stroke and mild to moderate hemiparesis (N=12 and an age-, gender-, and handedness-matched healthy comparison group (N=12 completed the BKT by reproducing three targeted reaching movements per hand with vision occluded. OTHER MEASURES: the Hand Active Sensation Test (HASTe, Touch-Test(tm monofilament aesthesiometer, 6-item Wolf Motor Function Test (Wolf, the Motor Activity Log (MAL, and the Box and Blocks Test (BBT. A paired t-test compared BKT scores between groups. Pearson product-moment correlation coefficients assessed the relationship between BKT scores and other measures. RESULTS: Post-stroke participants performed more poorly on the BKT than comparison participants with their contralesional and ipsilesional upper extremity. The mean difference for the contralesional upper extremity was 3.7 cm (SE=1.1, t=3.34; p<0.008. The BKT score for the contralesional limb was strongly correlated with the MAL-how much (r=0.84, p=0.001, the MAL-how well (r=0.76, p=0.007, Wolf (r=0.69, p=0.02, and the BBT (r=0.77, p=0.006. CONCLUSIONS: The BKT was feasible to administer and sensitive to differences in reaching accuracy between persons with stroke and a comparison group. With further refinement, The BKT may become a valuable clinical measure of post-stroke kinesthetic impairment.

  10. Development of an umami taste sensitivity test and its clinical use.

    Directory of Open Access Journals (Sweden)

    Shizuko Satoh-Kuriwada

    Full Text Available There is a close relationship between perception of umami, which has become recognized as the fifth taste, and the human physical condition. We have developed a clinical test for umami taste sensitivity using a filter paper disc with a range of six monosodium glutamate (MSG concentrations. We recruited 28 patients with taste disorders (45-78 years and 184 controls with no taste disorders (102 young [18-25 years] and 82 older [65-89 years] participants. Filter paper discs (5 mm dia. were soaked in aqueous MSG solutions (1, 5, 10, 50, 100 and 200 mM, then placed on three oral sites innervated by different taste nerves. The lowest concentration participants correctly identified was defined as the recognition threshold (RT for MSG. This test showed good reproducibility for inter- and intra-observer variability. We concluded that: (1 The RT of healthy controls differed at measurement sites innervated by different taste nerves; that is, the RT of the anterior tongue was higher than that of either the posterior tongue or the soft palate in both young and older individuals. (2 No significant difference in RT was found between young adults and older individuals at any measurement site. (3 The RT of patients with taste disorders was higher before treatment than that of the healthy controls at any measurement site. (4 The RT after treatment in these patients improved to the same level as that of the healthy controls. (5 The cutoff values of RT, showing the highest diagnostic accuracy (true positives + true negatives, were 200 mM MSG for AT and 50 mM MSG for PT and SP. The diagnostic accuracy at these cutoff values was 0.92, 0.87 and 0.86 for AT, PT and SP, respectively. Consequently, this umami taste sensitivity test is useful for discriminating between normal and abnormal umami taste sensations.

  11. Preliminary Tests of Nose- and Side- Entrance Blower Cooling Systems for Radial Engines, Special Report

    Science.gov (United States)

    Biermann, David; Valentine, E. Floyd

    1939-01-01

    Two cowling systems intended to reduce the drag and improve the low-speed cooling characteristics of conventional radial engine cowlings were tested in model form to determine the practicability of the methods. One cowling included a blower mounted on the rear face of a large propeller spinner which drew cooling air in through side entrance ducts located behind the equivalent engine orifice plate. The air was passed through the equivalent engine orifice plate from rear to front and out through a slot between the spinner and the engine plate. The blower produced substantially all the power necessary to circulate the cooling air in some cases, so the quantity of air flowing was independent of the air speed, Two types of blowers were used, a centrifugal type and one using airfoil blades which forced the air outward from the center of rotation. The other cowling was similar to the conventional N.A.C.A. cowling except for the addition of a large propeller spinner nose. The spinner was provided with a hole in the nose to admit cooling air and blower blades to increase the pressure for cooling at low speeds. The tests show that with both cowling types the basic drag of the nacelle was reduced substantially below that for the N.A.C.A. cowling by virtue of the better nose shape made possible by the spinner . The drag due to the side-entrance ducts was nearly zero when the openings were closed or when the blower was drawing in a certain quantity of air in proportion to the air speed. The drag increased, however, when air mas allowed to spill from the openings. The nose-entrance blower showed considerable promise as a cooling means although the blower tested was relatively inefficient, owing to the fact that the blower compartments evidently were expanded too rapidly under the conditions imposed. by the design.

  12. A preliminary guidebook for identifying stratigraphic contacts at the Nevada Test Site

    Energy Technology Data Exchange (ETDEWEB)

    Pawloski, G.A.; McKague, H.L.; Wagoner, J.L. [Lawrence Livermore National Lab., CA (United States); McKinnis, W.B. [Lawrence Livermore National Lab., Mercury, NV (United States)

    1992-01-01

    Lithologic variation, regional depositional trends, and the lack of written guidelines have resulted in inconsistencies in the recognition of stratigraphic contacts in drill holes at the Nevada Test Site (NTS). Stratigraphic identification, based on mineralogy of discrete samples, can be augmented by geophysical logs and downhole movies to more accurately and consistently locate contacts between units. Criteria are established for locating the base of the Pahute Mesa ash-flow tuff, the top of the Ammonia Tanks ash-flow tuff, the top of the Ammonia Tanks bedded tuff, and the top and the base of the Rainier Mesa Tuff.

  13. Blood splash in lambs-a preliminary study using the one-stage prothrombin time test.

    Science.gov (United States)

    Restall, D J

    1981-02-01

    Lambs from a flock in which a high incidence of blood splash had been detected were examined using the one-stage prothrombin test. For comparison lambs from a commercial slaughter line were also examined. All the affected lambs and 35·4% from the slaughter line had extended prothrombin times, and a relationship between extended prothrombin times and the occurrence of blood splash was established. Investigation of the pastures grazed by the affected flock showed the presence of coumarin producing plants and grasses. Some coumarin drugs prolong one-stage prothrombin times, and more importantly, induce capillary fragility, thus predisposing animals to blood splash.

  14. The Gaia-FUN-SSO observation campaign of 99942 Apophis: A preliminary test for the network

    CERN Document Server

    Bancelin, D; Ivantsov, A; Desmars, J; Assafin, M; Eggl, S; Hestroffer, D; Rocher, P; Carry, B; David, P

    2016-01-01

    In order to test the coordination and evaluate the overall performance of the Gaia-FUN-SSO, an observation campaign on the Potentially Hazardous Asteroid (99 942) Apophis was conducted from 12/21/2012 to 5/2/2013 providing 2732 high quality astrometric observations. We show that a consistent reduction of astrometric campaigns with reliable stellar catalogs substantially improves the quality of astrometric results. We present evidence that the new data will help to reduce the orbit uncertainty of Apophis during its close approach in 2029.

  15. Word memory test performance in Canadian adolescents with learning disabilities: a preliminary study.

    Science.gov (United States)

    Larochette, Anne-Claire; Harrison, Allyson G

    2012-01-01

    The purpose of this study was to evaluate Word Memory Test (WMT) performances in students with identified learning disabilities (LDs) providing good effort to examine the influence of severe reading or learning problems on WMT performance. Participants were 63 students with LDs aged 11 to 14 years old (M = 12.19 years), who completed psychoeducational assessments as part of a transition program to secondary school. Participants were administered a battery of psychodiagnostic tests including the WMT. Results indicated that 9.5% of students with LD met Criterion A on the WMT (i.e., perform below cut-offs on any of the first three subtests of the WMT), but less than 1% met both criteria necessary for identification of low effort. Failure on the first three subtests of the WMT was associated with word reading at or below the 1st percentile and severely impaired phonetic decoding and phonological awareness skills. These results indicate that the majority of students with a history of LD are capable of passing the WMT, and use of profile analysis reduces the false-positive rate to below 1%.

  16. Preliminary CFD Assessment of an Experimental Test Facility Operating with Heavy Liquid Metals

    Directory of Open Access Journals (Sweden)

    Matteo Lizzoli

    2017-01-01

    Full Text Available The CFD analysis of a Venturi nozzle operating in LBE (key component of the CIRCE facility, owned by ENEA is presented in this paper. CIRCE is a facility developed to investigate in detail the fluid-dynamic behavior of ADS and/or LFR reactor plants. The initial CFD simulations have been developed hand in hand with the comparison with experimental data: the test results were used to confirm the reliability of the CFD model, which, in turn, was used to improve the interpretation of the experimental data. The Venturi nozzle is modeled with a 3D CFD code (STAR-CCM+. Later on, the CFD model has been used to assess the performance of the component in conditions different from the ones tested in CIRCE: the performance of the Venturi is presented, in terms of pressure drops, for various operating conditions. Finally, the CFD analysis has been focused on the evaluation of the effects of the injection of an inert gas in the flow of the liquid coolant on the performance of the Venturi nozzle.

  17. Clinical utility of the Multiple Errands Test in schizophrenia: A preliminary assessment.

    Science.gov (United States)

    Bulzacka, Ewa; Delourme, Gwenaëlle; Hutin, Valérie; Burban, Nathalie; Méary, Alexandre; Lajnef, Mohamed; Leboyer, Marion; Schürhoff, Franck

    2016-06-30

    Schizophrenia (SZ) is a chronic, severe disease, which results in misperception of reality, major social withdrawal, and cognitive disturbances. One type of cognitive disturbance, known as executive dysfunction, is widely considered as a primary determinant of functional outcome. However, classic neuropsychological measures of executive functioning (EF) poorly represent patients' functional outcome, and thus seem inappropriate for evaluating the real-world functional impact of diseases such as SZ. We hypothesized that the Multiple Errands Test (MET), an ecological assessment of executive function would show greater ability to measure everyday adaptive functioning SZ, compared to conventional EF assessment methods. 100 clinically stable SZ patients were administered the MET, Wisconsin Card Sorting Test - 64 and a paper version of MET. Correlation analyses were performed between each EF measure and functional outcome, as measured by the Social Autonomy Scale (SAS). After adjusting for age, education, IQ and illness duration, SAS was significantly predicted by MET global score. No other EF measure correlated with SAS. Results from this study suggest that MET offers a valuable prediction of daily life functional outcome in this large sample of SZ patients. Therefore, it could be used as a complementary measure to improve the identification of executive dysfunctions prior to psychosocial interventions.

  18. High-resolution cross-borehole thermal tracer testing in granite: preliminary field results

    Science.gov (United States)

    Brixel, Bernard; Klepikova, Maria; Jalali, Mohammadreza; Amann, Florian; Loew, Simon

    2017-04-01

    Understanding how heat is transported, stored and exchanged across fractured media is becoming increasingly relevant in our society, as manifested from the growing popularity of modern technologies relying on the subsurface to either source or store heat. One good example is the utilization of heat from deep hydrothermal or petrothermal systems to generate electricity for base load power generation, a technology also known as deep geothermal energy (DGE). While very attractive in principle, the number of geothermal fields producing economical levels of electricity to this day is still very limited - largely due to the difficulty of either locating deep reservoirs that are both sufficiently hot and permeable or, in the absence of the latter, creating them. In this context, the Swiss Competence Center for Energy Research - Supply of Electricity (SCCER - SoE) is carrying out an in situ stimulation and circulation (ISC) experiment at the Grimsel Test Site (GTS), an underground rock lab located in the Aar massif, in the Swiss Alps. The circulation experiment planned for the post-stimulation phase represents one of the key components of this experimental research program, and the outcome of this test is expected to ultimately provide key insights in the factors controlling the performance of enhanced geothermal reservoirs. Therefore, to support the design of this experiment, short-term thermal tracer tests (TTT) were conducted with the objective to (i) assess the feasibility of conducting TTTs in a relatively intact granite (where fluid flow is controlled by a limited number of discrete fractures); (ii) determine optimal experimental setups; and to ultimately (iii) monitor thermal breakthroughs at high spatial and temporal resolution, providing insights on heat transport and complementing the characterization of hydrogeological conditions carried out through conventional means (e.g. hydraulic and/or solute tracer tests). Presented herein are the results of a 10-day

  19. Preliminary tests of silicon carbide based concretes for hybrid rocket nozzles in a solar furnace

    Science.gov (United States)

    D'Elia, Raffaele; Bernhart, Gérard; Cutard, Thierry; Peraudeau, Gilles; Balat-Pichelin, Marianne

    2014-06-01

    This research is part of the PERSEUS project, a space program concerning hybrid propulsion and supported by CNES. The main goal of this study is to characterise silicon carbide based micro-concrete with a maximum aggregates size of 800 μm, in a hybrid propulsion environment. The nozzle throat has to resist to a highly oxidising polyethylene (PE)/N2O hybrid environment, under temperatures ranging up to 2980 K. The study is divided into two main parts: the first one deals with the thermo-mechanical characterisation of the material up to 1500 K and the second one with an investigation on the oxidation behaviour in a standard atmosphere, under a solar flux up to 13.5 MW/m2. Young's modulus was determined by resonant frequency method: results show an increase with the stabilisation temperature. Four point bending tests have shown a rupture tensile strength increasing with stabilisation temperature, up to 1473 K. Sintering and densification processes are primary causes of this phenomenon. Visco-plastic behaviour appears at 1373 K, due to the formation of liquid phases in cement ternary system. High-temperature oxidation in ambient air was carried out at PROMES-CNRS laboratory, on a 2 kW solar furnace, with a concentration factor of 15,000. A maximum 13.5 MW/m2 incident solar flux and a 7-90 s exposure times have been chosen. Optical microscopy, SEM, EDS analyses were used to determine the microstructure evolution and the mass loss kinetics. During these tests, silicon carbide undergoes active oxidation with production of SiO and CO smokes and ablation. A linear relation between mass loss and time is found. Oxidation tests performed at 13.5 MW/m2 solar flux have shown a mass loss of 10 mg/cm2 after 15 s. After 90 s, the mass loss reaches 60 mg/cm2. Surface temperature measurement is a main point in this study, because of necessity of a thermo-mechanical-ablative model for the material. Smokes appear at around 5.9 MW/m2, leading to the impossibility of useful temperature

  20. Preliminary Study on Mg content of hard part(Test) of a benthic foraminifer from the inner shelf, off West Coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Khare, N.; Nigam, R.; Iyer, S.D.

    A preliminary study has been made for trace element (Mg) in the test of benthic species Bulimina exilis from a shallow sediment core (at 22 m water depth) off west coast of India using Electron Probe Microanalyser (EPMA) The Mg content is selected...

  1. Quantifying microwear on experimental Mistassini quartzite scrapers: preliminary results of exploratory research using LSCM and scale-sensitive fractal analysis.

    Science.gov (United States)

    Stemp, W James; Lerner, Harry J; Kristant, Elaine H

    2013-01-01

    Although previous use-wear studies involving quartz and quartzite have been undertaken by archaeologists, these are comparatively few in number. Moreover, there has been relatively little effort to quantify use-wear on stone tools made from quartzite. The purpose of this article is to determine the effectiveness of a measurement system, laser scanning confocal microscopy (LSCM), to document the surface roughness or texture of experimental Mistassini quartzite scrapers used on two different contact materials (fresh and dry deer hide). As in previous studies using LSCM on chert, flint, and obsidian, this exploratory study incorporates a mathematical algorithm that permits the discrimination of surface roughness based on comparisons at multiple scales. Specifically, we employ measures of relative area (RelA) coupled with the F-test to discriminate used from unused stone tool surfaces, as well as surfaces of quartzite scrapers used on dry and fresh deer hide. Our results further demonstrate the effect of raw material variation on use-wear formation and its documentation using LSCM and RelA. © Wiley Periodicals, Inc.

  2. High density trans-admittance mammography development and preliminary phantom tests

    Directory of Open Access Journals (Sweden)

    Zhao Mingkang

    2012-09-01

    Full Text Available Abstract Background Malignant breast tumor tissue has a significantly different electrical impedance spectrum than surrounding normal tissues. This has led to the development of impedance imaging as a supplementary or alternative method to X-ray mammography for screening and assessment of breast cancers. However low spatial resolution and poor signal to noise ratio has limited the clinical application. Methods In order to improve spatial resolution we developed a trans-admittance mammography (TAM system including an array of 60×60 current sensing electrodes. We adopted a similar setup to X-ray mammography where the breast is situated between two holding plates. The top plate is a large solid metal electrode for applying a sinusoidal voltage over a range of frequencies from 50 Hz to 500 kHz. The bottom plate has 3600 current sensing electrodes that are kept at the ground potential. Currents are generated from the top voltage-applying electrode and spread throughout the breast, entering the TAM system through the array of current sensing electrodes on the bottom plate. The TAM system measures the exit currents through 6 switching modules connected to 600 electrodes each. Each switching module is connected to 12 ammeter channels which are switched sequentially to 50 of the 600 electrodes each measurement time. Each ammeter channel is comprised of a current-to-voltage converter, a gain amplifier, filters, an analog to digital converter, and a digital phase sensitive demodulator. Results We found an average noise level of 38 nA, amplitude stability of less than 0.2%, crosstalk of better than -60 dB and 70 dB signal to noise ratio over all channels and operating frequencies. Images were obtained in time difference and frequency difference modes in a saline phantom. Conclusion We describe the design, construction, and calibration of a high density TAM system in detail. Successful high resolution time and frequency difference images showed regions of

  3. Preliminary Beam Tests at REX for an Automatic Cavity Phasing Routine at HIE-ISOLDE

    CERN Document Server

    Fraser, M A; Broere, J; Lanaia, D; Valuch, D

    2013-01-01

    The HIE upgrade at ISOLDE will use 32 independently phased superconducting quarterwave cavities, which will impose new demands on the operation and set-up of the linac. The large range of different radioactive species and the broad experimental programme means that the same beam species and energy are rarely studied twice, and the accelerator must be re-tuned for each experimental run. In order to expedite machine set-up it is foreseen to calculate and set automatically the cavity phases when the operator inputs the desired beam energy and A/q of the beam species. In this note we explore our understanding of the REX rf system and test our beam dynamics calculations with two independently phased 7-gap split-ring cavities.

  4. Preliminary testing of the role of exercise and predator recognition for bonytail and razorback sucker

    Science.gov (United States)

    Mueller, Gordon A.; Carpenter, Jeanette; Krapfel, Robert; Figiel, Chester

    2007-01-01

    Hatchery-reared juvenile, suckers appeared curious and showed no sign of predator avoidance when initially placed with large (>45-cm TL) flathead catfish. Predator-naïve juveniles (20- to 25-cm TL) exhibited no discernable preference when provided areas with and without (52 percent and 48 percent, n = 16 observations; 46 percent and 54 percent, n = 20 observations) large flathead catfish. However, once predation occurred, use of predator-free areas nearly doubled in two trials (36 percent and 64 percent, n = 50 observations; 33 percent and 67 percent, n = 12 observations). A more stringent test examining available area indicated predator-savvy razorback suckers used predator-free areas (88 percent, n = 21) illustrating predator avoidance was a learned behavior.

  5. Preliminary design of mesoscale turbocompressor and rotordynamics tests of rotor bearing system

    Science.gov (United States)

    Hossain, Md Saddam

    2011-12-01

    A mesoscale turbocompressor spinning above 500,000 RPM is evolutionary technology for micro turbochargers, turbo blowers, turbo compressors, micro-gas turbines, auxiliary power units, etc for automotive, aerospace, and fuel cell industries. Objectives of this work are: (1) to evaluate different air foil bearings designed for the intended applications, and (2) to design & perform CFD analysis of a micro-compressor. CFD analysis of shrouded 3-D micro compressor was conducted using Ansys Bladegen as blade generation tool, ICEM CFD as mesh generation tool, and CFX as main solver for different design and off design cases and also for different number of blades. Comprehensive experimental facilities for testing the turbocompressor system have been also designed and proposed for future work.

  6. Some Preliminary Notes on an Empirical Test of Freud’s Theory on Depression

    Directory of Open Access Journals (Sweden)

    Mattias eDesmet

    2013-05-01

    Full Text Available A review of the literature indicates that empirical researchers have difficulty translating Freud’s theory on depression into appropriate research questions and hypotheses. In their attempt to do so, the level of complexity in Freud’s work is often lost. As a result, what is empirically tested is no more than a caricature of the original theory. To help researchers avoid such problems, this study presents a conceptual analysis of Freud’s theory of depression as it is presented in Mourning and Melancholia (Freud, 1917. In analyzing Freud’s theory on the etiology of depression, it is essential to differentiate between (1 an identification with the satisfying and frustrating aspects of the love object, (2 the inter- and an intrapersonal loss of the love object, and (3 conscious and unconscious dynamics. A schematic representation of the mechanism of depression is put forward and a research design by which this schema can be empirically investigated is outlined.

  7. Preliminary indications for antibiotic susceptibility tests in less than six hour in positive blood cultures

    Directory of Open Access Journals (Sweden)

    Vesselina Kroumova

    2010-03-01

    Full Text Available A rapid determination of the antibiotic susceptibility patterns of pathogens responsible for sepsis represents a significant milestone for a timely correct antibiotic therapy.The system HB&L® (ALIFAX allows reduced time in the detection of bacterial growth and consequently is able to detect the growth or absence of certain microorganisms in the presence of a given antibiotic. In this study three system for rapid antibiotic susceptibility tests among bacteria isolated from blood were compared: HB&L® (ALIFAX,VITEK®2 (bioMérieux and essays Etest® (bioMérieux. Present findings indicate that HB&L® (ALIFAX is rapid reliable instrument that may support the clinician for a rapid and appropriate treatment, particularly in the critical patient.

  8. [Preliminary application of video head impulse test in the diagnosis of vertigo].

    Science.gov (United States)

    Zhang, Yanmei; Chen, Siqi; Zhong, Zhen; Chen, Li; Wu, Yuanding; Zhao, Guiping; Liu, Yuhe

    2015-06-01

    To investigate clinical application of head impulse test with video recording eye movements in the diagnosis of vertigo. The video head impulse test(vHIT) was used to measure the eye saccades and velocity gain in 95 patients with vertigo which were divided into two groups, peripheral vertigo (47 cases) and central vertigo(48 cases); the characteristics of eye saccades and velocity gain of six semicircular canals in different patients with vertigo were analyzed, and were compared between the two groups. The vHIT result in patients with peripheral vertigo: in 22 patients (23 affected ears) with Meniere's disease, 21 ears were abnormal (91. 3%); the vHIT results in 4 patients with vestibular schwannoma, 2 patients with vestibular neuritis, 5 patients with delayed endolymphatic hydrops, 6 patients with sudden hearing loss accompanied vertigo, and 8 patients with vestibular dysfunction, were abnormal with correct saccades and/or lower velocity gain of vHIT. The abnormal vHIT results were also found in 35 of 48 patients (72. 9%) with central vertigo, which including posterior cerebral circulation ischemia(7 patients), cerebral infarction/stroke(6 patients), and dizziness with vertigo(17 patients) and others(18 patients). Abnormal rate of vHIT in patients with peripheral vertigo was 95. 7% (45/47), which was significantly higher than that (72. 9%) in patients with central vertigo. It is easy to perform the vHIT which without adverse reactions. We can record high-frequency characteristics of vestibular-ocular reflex among six semicircular canals through vHIT. The vHIT results which show the function of vestibular ocular reflex in different diseases with vertigo, can help discriminate peripheral vertigo from central vertigo, and it is a practical assessment method for vertigo.

  9. [Development of external quality control protocol for CyberKnife beams dosimetry: preliminary tests multicentre].

    Science.gov (United States)

    Guinement, L; Marchesi, V; Veres, A; Lacornerie, T; Buchheit, I; Peiffert, D

    2013-01-01

    To develop an external quality control procedure for CyberKnife(®) beams. This work conducted in Nancy, has included a test protocol initially drawn by the medical physicist of Nancy and Lille in collaboration with Equal-Estro Laboratory. A head and neck anthropomorphic phantom and a water-equivalent homogeneous cubic plastic test-object, so-called "MiniCube", have been used. Powder and solid thermoluminescent dosimeters as well as radiochromic films have been used to perform absolute and relative dose studies, respectively. The comparison between doses calculated by Multiplan treatment planning system and measured doses have been studied in absolute dose. The dose distributions measured with films and treatment planning system calculations have been compared via the gamma function, configured with different tolerance criteria. This work allowed, via solid thermoluminescent dosimeter measurements, verifying the beam reliability with a reproducibility of 1.7 %. The absolute dose measured in the phantom irradiated by the seven participating centres has shown an error inferior to the standard tolerance limits (± 5 %), for most of participating centres. The relative dose measurements performed at Nancy and by the Equal-Estro laboratory allowed defining the most adequate parameters for gamma index (5 %/2mm--with at least 95 % of pixels satisfying acceptability criteria: γsoftware. This work allowed defining a dosimetric external quality control for CyberKnife(®) systems, based on a reproducible irradiation plan through measurements performed with thermoluminescent dosimeters and radiochromic films. This protocol should be validated by a new series of measurement and taking into account the lessons of this work. Copyright © 2013 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.

  10. Progeny test of tetraploid Betula platyphylla and preliminary selection of hybrid parents

    Institute of Scientific and Technical Information of China (English)

    Huanwen Xu; Yu Liu; Jing Jiang; Guifeng Liu; Xiyang Zhao

    2016-01-01

    Estimating genetic parameters of parental lines through progeny testing and choosing good hybrid parents are important for genetically improving seed orchard trees. In this study, 24 tetraploid progeny seedlings were used as experimental materials, which came from test cross design:six tetraploid Betula platyphylla lines (Q33, Q13, Q103, Q19, Q83 and Q14) as female parents and four individual B. platyphylla diploid lines (F3, F4, F9 and F11) as male parents were crossed. Variance analysis of height, diame-ter, height-to-diameter ratio, and internodal distance showed that the differences between hybrid combinations reached highly significant levels. Using multi-objective decisionmaking, we performed a comprehensive assess-ment of the various hybrid combinations. Using a selection rate of 20% of the standard, five hybrids were selected;their genetic gains in average height, diameter, height-to-diameter ratio, and internodal distance were 20.95, 6.07, 13.07 and 8.96%, respectively. We also analyzed the combining ability and genetic parameter effect values of parents and hybrid combinations. The combined analysis revealed that Q13, Q103, Q33 and Q83 were superior females; F3, F4, and F9 were superior males; and F3 9 Q13, F4 9 Q83 and F9 9 Q33 were superior hybrid combinations. The heights and diameters of these proge-nies were 22.49 and 11.48% greater than average, respectively.

  11. Patch test dose-response study: polysensitized individuals do not express lower elicitation thresholds than single/double-sensitized individuals.

    Science.gov (United States)

    Carlsen, B C; Fischer, L A; Sosted, H; Vølund, A; Menné, T; Johansen, J D

    2009-01-01

    It is not known if reduced elicitation thresholds are evident among polysensitized individuals when using allergens to which the patients are already sensitized. Reduced elicitation thresholds may be an expression of increased reactivity in this patient group. To examine and compare elicitation dose-response curves and elicitation thresholds in a polysensitized vs. a single/double-sensitized group for allergens to which the test subjects were already sensitized. Fifty-one patients (13 polysensitized and 38 single/double-sensitized) were patch tested with nickel sulphate, methyldibromo glutaronitrile (MDBGN) and p-phenylenediamine (PPD) in dilution series. The ratio between the doses eliciting a response in 50% of patients in the two groups was used as the measure for relative sensitivity. The dose-response curves of the polysensitized group for MDBGN and PPD were shifted to the right, and for nickel sulphate shifted to the left, compared with the single/double-sensitized group. The relative sensitivity for each of the three allergens and a combined relative sensitivity for all three allergens were not significantly different when comparing the polysensitized and single/double-sensitized groups. No increased sensitivity, in the form of distinct elicitation thresholds, could be demonstrated in polysensitized individuals compared with individuals with one or two contact allergies.

  12. Agreement between quantitative and qualitative sensory testing of changes in oro-facial somatosensory sensitivity.

    Science.gov (United States)

    Agbaje, J; De Laat, A; Constantinus, P; Svensson, P; Baad-Hansen, L

    2017-01-01

    Qualitative somatosensory testing (QualST) is a simple chairside test. It can be used to roughly assess the presence or absence of altered somatosensory function. To use QualST clinically, it is important to assess its agreement with quantitative sensory testing (QST). The aims of this study were to assess the agreement between QST and QualST when testing the modulation of facial sensitivity by capsaicin in healthy participants and to explore the agreement between QST and QualST in assessing the intraoral sensory function in clinical atypical odontalgia (AO) patients. Eighteen healthy pain-free adults and data from 27 AO patients were included in the study. Thirteen QST and three QualST parameters were evaluated at each site. Z-scores were computed for healthy participants, and Loss-Gain scores were created. The agreement observed between QST and QualST in participants with no alterations in facial sensation (placebo) was good, that is ranging from 89% to 94%. A poorer agreement was seen after capsaicin application in all test modalities with agreement ranging from 50% to 72%. The commonest misclassification observed was participants classified as normal according to QST, but hyper- or hyposensitive according to QualST after capsaicin application, especially for cold and pinprick. A similar trend was observed in AO patients where patients classified as normal using QST were misclassified as hypersensitive and in few patients as hyposensitive by QualST. In conclusion, the study showed that QualST may be used as a screening tool in the clinical setting, especially to show that subjects have normal sensory function.

  13. Low specificity and sensitivity of smell identification testing for the diagnosis of Parkinson?s disease

    Directory of Open Access Journals (Sweden)

    Mayela Rodríguez-Violante

    2014-01-01

    Full Text Available Objective: The aim of this study is to determine if the University of Pennsylvania’s Smell Identification Test (UPSIT is an accurate diagnostic tool for olfactory dysfunction in Parkinson’s disease (PD. Method: We included 138 non-demented PD subjects and 175 control subjects matched by gender. Smell identification was tested using UPSIT. Results: The mean number of UPSIT items correctly identified by controls was 27.52±5.88; the mean score for PD subjects was 19.66±6.08 (p=<0.001. UPSIT sensitivity was 79.7% with a specificity of 68.5% using a cut-off score of ≤25. The overall accuracy for the diagnosis of PD was of 75.3%. Conclusion: UPSIT accuracy and specificity were lower than what has been previously reported. Our data demonstrates that 17.5% of items of the UPSIT were not well identified by healthy controls. Further research of the identification of a truly cross-cultural test is warranted.

  14. Low specificity and sensitivity of smell identification testing for the diagnosis of Parkinson's disease.

    Science.gov (United States)

    Rodríguez-Violante, Mayela; Gonzalez-Latapi, Paulina; Camacho-Ordoñez, Azyadeh; Martínez-Ramírez, Daniel; Morales-Briceño, Hugo; Cervantes-Arriaga, Amin

    2014-01-01

    The aim of this study is to determine if the University of Pennsylvania's Smell Identification Test (UPSIT) is an accurate diagnostic tool for olfactory dysfunction in Parkinson's disease (PD). We included 138 non-demented PD subjects and 175 control subjects matched by gender. Smell identification was tested using UPSIT. The mean number of UPSIT items correctly identified by controls was 27.52 ± 5.88; the mean score for PD subjects was 19.66 ± 6.08 (p=<0.001). UPSIT sensitivity was 79.7% with a specificity of 68.5% using a cut-off score of ≤ 25. The overall accuracy for the diagnosis of PD was of 75.3%. UPSIT accuracy and specificity were lower than what has been previously reported. Our data demonstrates that 17.5% of items of the UPSIT were not well identified by healthy controls. Further research of the identification of a truly cross-cultural test is warranted.

  15. ADVANCED UTILITY SIMULATION MODEL, REPORT OF SENSITIVITY TESTING, CALIBRATION, AND MODEL OUTPUT COMPARISONS (VERSION 3.0)

    Science.gov (United States)

    The report gives results of activities relating to the Advanced Utility Simulation Model (AUSM): sensitivity testing. comparison with a mature electric utility model, and calibration to historical emissions. The activities were aimed at demonstrating AUSM's validity over input va...

  16. In vitro sensitivity testing of Cladobotryum mycophilum to carbendazim and prochloraz manganese

    Directory of Open Access Journals (Sweden)

    Alinesi Chakwiya

    2015-11-01

    Full Text Available Limited information of fungicide efficacy on cultivated mushrooms and resistance development potential is available. Minor crop industries in general have a smaller arsenal of protectants to rely on and the likelihood of resistance build-up is of greater concern. This study focused on Cladobotryum mycophilum's sensitivity to carbendazim and prochloraz manganese following recent reports on decreased efficacy of both fungicides. The median effective dose (ED50 values for carbendazim ranged between 0.02 mg/L and 4.31 mg/L with 60% of the South African isolates being moderately resistant. The highest resistance factor for carbendazim was 215. Prochloraz manganese ED50 values varied from 0.00001 mg/L to 0.55 mg/L. A significant difference in mean ED50 values for both fungicides tested was observed. Using cluster analysis, no discrimination of isolates previously exposed and unexposed to prochloraz manganese was observed. A wide range of differences in ED50 values indicated moderate resistance to carbendazim and high sensitivity to prochloraz manganese among isolates under investigation. Discriminant analysis indicated significant differences between clusters contributed by one or a few variables. This study provided evidence that prochloraz manganese remains highly fungitoxic to C. mycophilum. However, prochloraz manganese is to be used in a disease management strategy in combination with strict farm hygiene management strategies to retain product efficacy and ensure crop protection.

  17. Sensitivity of soil phosphorus tests in predicting the potential risk of phosphorus loss from pasture soil

    Directory of Open Access Journals (Sweden)

    H. SOINNE

    2008-12-01

    Full Text Available The objective of this study was to examine the effects of urine and dung additions on the phosphorus (P chemistry of pasture land and to compare the sensitivity of two soil extraction methods in assessing the P-loading risk. In a field experiment, urine and dung were added to soil in amounts corresponding to single excrement portions and the soil samples, taken at certain intervals, were analysed for pHH2O, acid ammonium acetate extractable P (PAc and water extractable total P (TPw, and molybdate reactive P (MRPw. Urine additions immediately increased soil pH and MRPw, but no such response was observed in PAc extraction due to the low pH (4.65 of the extractant enhancing the resorption of P. The PAc responded to the dunginduced increase in soil total P similarly as did Pw, which suggests that both tests can serve to detect areas of high P concentration. However, water extraction was a more sensitive method for estimating short-term changes in P solubility. In pasture soils, the risk of P loss increases as a result of the interaction of urination and high P concentration in the topsoil resulting from continuous dung excretion.;

  18. Development of a simple test device for spindle error measurement using a position sensitive detector

    Science.gov (United States)

    Liu, Chien-Hung; Jywe, Wen-Yuh; Lee, Hau-Wei

    2004-09-01

    A new spindle error measurement system has been developed in this paper. It employs a design development rotational fixture with a built-in laser diode and four batteries to replace a precision reference master ball or cylinder used in the traditional method. Two measuring devices with two position sensitive detectors (one is designed for the measurement of the compound X-axis and Y-axis errors and the other is designed with a lens for the measurement of the tilt angular errors) are fixed on the machine table to detect the laser point position from the laser diode in the rotational fixture. When the spindle rotates, the spindle error changes the direction of the laser beam. The laser beam is then divided into two separated beams by a beam splitter. The two separated beams are projected onto the two measuring devices and are detected by two position sensitive detectors, respectively. Thus, the compound motion errors and the tilt angular errors of the spindle can be obtained. Theoretical analysis and experimental tests are presented in this paper to separate the compound errors into two radial errors and tilt angular errors. This system is proposed as a new instrument and method for spindle metrology.

  19. Identification of lung cancer with high sensitivity and specificity by blood testing

    Directory of Open Access Journals (Sweden)

    Stephan Bernhard

    2010-02-01

    Full Text Available Abstract Background Lung cancer is a very frequent and lethal tumor with an identifiable risk population. Cytological analysis and chest X-ray failed to reduce mortality, and CT screenings are still controversially discussed. Recent studies provided first evidence for the potential usefulness of autoantigens as markers for lung cancer. Methods We used extended panels of arrayed antigens and determined autoantibody signatures of sera from patients with different kinds of lung cancer, different common non-tumor lung pathologies, and controls without any lung disease by a newly developed computer aided image analysis procedure. The resulting signatures were classified using linear kernel Support Vector Machines and 10-fold cross-validation. Results The novel approach allowed for discriminating lung cancer patients from controls without any lung disease with a specificity of 97.0%, a sensitivity of 97.9%, and an accuracy of 97.6%. The classification of stage IA/IB tumors and controls yielded a specificity of 97.6%, a sensitivity of 75.9%, and an accuracy of 92.9%. The discrimination of lung cancer patients from patients with non-tumor lung pathologies reached an accuracy of 88.5%. Conclusion We were able to separate lung cancer patients from subjects without any lung disease with high accuracy. Furthermore, lung cancer patients could be seprated from patients with other non-tumor lung diseases. These results provide clear evidence that blood-based tests open new avenues for the early diagnosis of lung cancer.

  20. Possible Application of Raman Microspectroscopy to Verify the Interstitial Cystitis Diagnosis after Potassium Sensitivity Test: Phenylalanine or Tryptophan as a Biomarker

    Directory of Open Access Journals (Sweden)

    Tzu-Feng Hsieh

    2007-01-01

    Full Text Available There is lack of a worldwide standard technique for clinical diagnosis of interstitial cystitis (IC. Raman spectroscopy with higher specificity and sensitivity has been extensively used to act as a non-destructive analytical technique without special sample preparation. In this preliminary study, possible use of Raman microspectroscopy as an IC diagnostic tool was attempted. Twenty-two participants were screened by clinical features, history, urodynamic evaluations and potassium sensitivity test (PST. The freeze-dried water samples voided from all the participants after PST were directly determined by using a confocal Raman microspectroscopy to search the biomarker. Participants with or without IC symptom were separated into control and clinical groups, according to the above screening. The participants in the clinical group were further divided into mild and severe subgroups by PST. The symptom of urinary pain and urgency was significant difference between the mild and severe subgroups (p < 0.05. A significant increase in urinary frequency but a marked reduction in bladder capacity, maximum cystometric capacity and maximum voiding flow rate were obtained for clinical group of IC participants, as compared with the result of control group (p < 0.05. By using Raman microspectroscopic determination, the band near 1003 or 1005 cm−1 assigned to phenylalanine was respectively detected from the freeze-dried water sample of control group or mild subgroup, but the band at 1010 cm−1 due to tryptophan was found in the freeze-dried water sample of severe subgroup. The result of this preliminary study first suggests a possible application of Raman microspectroscopy to strongly certify the results of PST for IC diagnosis. Phenylalanine or tryptophan might be acted as a biomarker to assist the diagnosis of IC after PST. Particularly, the appearance of tryptophan might be used to discriminate the severity of IC symptom.

  1. Sensitivity analysis and numerical experiments on transient test of compact heat exchanger surfaces

    Institute of Scientific and Technical Information of China (English)

    Hesheng REN; Lingjun LAI; Yongzheng CUI

    2008-01-01

    A single-blow transient testing technique con-sidering the effect of longitudinal heat conduction is sug-gested for determining the average convection heat transfer coefficient of compact heat exchanger surface. By matching the measured outlet fluid temperature vari-ation with similar theoretical curves, the dimensionless longitudinal conduction parameter λ1, the time constant of the inlet fluid temperature τ+, and the number of heat transfer units Ntu can be determined simultaneously using the Levenberg-Marquardt nonlinear parameter estima-tion method. Both sensitivity analysis and numerical experiments with simulated measurements containing random errors show that the method in the present invest-igation provides satisfactory accuracy of the estimated parameter Ntu, which characterizes the heat transfer per-formance of compact heat exchanger surfaces.

  2. The Adoption of a Standardized Antibiotic Sensitivity Test in the Philippines

    Directory of Open Access Journals (Sweden)

    Thelma Tupasi-Ramos

    1980-01-01

    Full Text Available With the development and the introduction of a great variety of antibiotic and chemotherapeutic agents, the outlook in the treatment of infections has improved significantly. Unfortunately, however, these agents are not necessarily innocuous to human tissues, so that their use in some instances is associated with some potential hazards including tissue toxicity, hypersensitivity reaction, emergence of bacterial antimicrobial resistance and the development of clinical superinfection. In view of these hazards, therefore, the administration of an antibiotic must be initiated only when there are definite objective evidences of an infection from clinical and laboratory parameters. Furthermore, the choice of antibiotic must be based on objective results of the antibiotic sensitivity test done on the isolated etiologic agent.

  3. High sensitivity tests of the Pauli Exclusion Principle with VIP2

    CERN Document Server

    Marton, J; Bertolucci, S; Berucci, C; Bragadireanu, M; Cargnelli, M; Curceanu, C; Clozza, A; Di Matteo, S; Egger, J-P; Guaraldo, C; Iliescu, M; Ishiwatari, T; Laubenstein, M; Milotti, E; Pichler, A; Pietreanu, D; Piscicchia, K; Ponta, T; Scordo, A; Shi, H; Sirghi, D L; Sirghi, F; Sperandio, L; Doce, O Vazquez; Widmann, E; Zmeskal, J

    2015-01-01

    The Pauli Exclusion Principle is one of the most fundamental rules of nature and represents a pillar of modern physics. According to many observations the Pauli Exclusion Principle must be extremely well fulfilled. Nevertheless, numerous experimental investigations were performed to search for a small violation of this principle. The VIP experiment at the Gran Sasso underground laboratory searched for Pauli-forbidden X-ray transitions in copper atoms using the Ramberg-Snow method and obtained the best limit so far. The follow-up experiment VIP2 is designed to reach even higher sensitivity. It aims to improve the limit by VIP by orders of magnitude. The experimental method, comparison of different PEP tests based on different assumptions and the developments for VIP2 are presented.

  4. Preliminary Correlation Map of Geomorphic Surfaces in North-Central Frenchman Flat, Nevada Test Site

    Energy Technology Data Exchange (ETDEWEB)

    Bechtel Nevada

    2005-08-01

    This correlation map (scale = 1:12,000) presents the results of a mapping initiative that was part of the comprehensive site characterization required to operate the Area 5 Radioactive Waste Management Site, a low-level radioactive waste disposal facility located in northern Frenchman Flat at the Nevada Test Site. Eight primary map units are recognized for Quaternary surfaces: remnants of six alluvial fan or terrace surfaces, one unit that includes colluvial aprons associated with hill slopes, and one unit for anthropogenically disturbed surfaces. This surficial geology map provides fundamental data on natural processes for reconstruction of the Quaternary history of northern Frenchman Flat, which in turn will aid in the understanding of the natural processes that act to develop the landscape, and the time-frames involved in landscape development. The mapping was conducted using color and color-infrared aerial photographs and field verification of map unit composition and boundaries. Criteria for defining the map unit composition of geomorphic surface units are based on relative geomorphic position, landform morphology, and degree of preservation of surface morphology. The bedrock units identified on this map were derived from previous published mapping efforts and are included for completeness.

  5. Preliminary operational results of the low-temperature solar industrial process heat field tests

    Energy Technology Data Exchange (ETDEWEB)

    Kutscher, C.F.; Davenport, R.L.

    1980-06-01

    Six solar industrial process heat field tests have been in operation for a year or more - three are hot water systems and three are hot air systems. All are low-temperature projects (process heat at temperatures below 212/sup 0/F). Performance results gathered by each contractor's data acquisition system are presented and project costs and problems encountered are summarized. Flat-plate, evacuated-tube, and line-focus collectors are all represented in the program, with collector array areas ranging from 2500 to 21,000 ft/sup 2/. Collector array efficiencies ranged from 12% to 36% with net system efficiencies from 8% to 33%. Low efficiencies are attributable in some cases to high thermal losses and, for the two projects using air collectors, are due in part to high parasitic power consumption. Problems have included industrial effluents on collectors, glazing and absorber surface failures, excessive thermal losses, freezing and overheating, control problems, and data acquisition system failure. With design and data acquisition costs excluded costs of the projects ranged from $25/ft/sup 2/ to $87/ft/sup 2/ and $499/(MBtu/yr) to $1537/(MBtu/yr).

  6. Preliminary photovoltaic arc-fault prognostic tests using sacrificial fiber optic cabling.

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Jay Dean; Blemel, Kenneth D.; Peter, Francis

    2013-02-01

    Through the New Mexico Small Business Assistance Program, Sandia National Laboratories worked with Sentient Business Systems, Inc. to develop and test a novel photovoltaic (PV) arc-fault detection system. The system operates by pairing translucent polymeric fiber optic sensors with electrical circuitry so that any external abrasion to the system or internal heating causes the fiber optic connection to fail or detectably degrade. A periodic pulse of light is sent through the optical path using a transmitter-receiver pair. If the receiver does not detect the pulse, an alarm is sounded and the PV system can be de-energized. This technology has the unique ability to prognostically determine impending failures to the electrical system in two ways: (a) the optical connection is severed prior to physical abrasion or cutting of PV DC electrical conductors, and (b) the polymeric fiber optic cable melts via Joule heating before an arc-fault is established through corrosion. Three arc-faults were created in different configurations found in PV systems with the integrated fiber optic system to determine the feasibility of the technology. In each case, the fiber optic cable was broken and the system annunciated the fault.

  7. The physical education predisposition scale: Preliminary tests of reliability and validity in Australian students.

    Science.gov (United States)

    Hilland, Toni A; Brown, Trent D; Fairclough, Stuart J

    2017-03-30

    The main aim of this study was to psychometrically test the Physical Education Predisposition Scale (PEPS) with a cohort of Australian students, to assess secondary school students' perceived PE ability and PE worth. Secondary aims were to explore how the two variables were related and to investigate age and gender differences. Altogether, 266 Year 7, 8, 9 and 10 students (aged 12-16 years), from four schools within the South Eastern region of Melbourne, completed the PEPS at both time points. Principal components analysis revealed the presence of a simple two-factor structure explaining 66.9% of the variance. Factor 1 (labelled perceived PE worth) reflected enjoyment and attitude (α = .91), and factor 2 (labelled perceived PE ability) represented perceptions of competence and self-efficacy (α = .92). Significant positive correlations were observed between the two factors (r = .50-.82, P < .001). Boys scored significantly higher than girls on perceived PE ability (P = .01), and year 7 students scored significantly higher compared to Year 9 students (P = .002). Our results support the potential of the PEPS as a concise measurement tool for use in the PE setting, for both teachers and researchers.

  8. ANALYSIS OF THE FORCE DURING OVERCOMING THE ROADBLOCK – THE PRELIMINARY EXPERIMENTAL TESTS

    Directory of Open Access Journals (Sweden)

    Jakub POLASIK

    2016-03-01

    Full Text Available The paper applies to the issue of preservation of passenger vehicles during overcoming the roadblocks on a dry asphalt surface with the constant speed. The study aimed to estimate the forces which are affecting the suspension of the vehicle during the contact between a tyre and roadblock. Using the video recording it is possible to calculate the values of the tyre deflection and forces acting in the system. The obtained deflections of the tyres were compared to earlier laboratory test results and load-deflection characteristics of the tyres with the same size. The roadblock with the defined geometry causes a dynamic deflection of the tyre. During the study a significant change in the geometry of the suspension has not occurred. The paper presents the characteristics of the vehicles research with a particular regard to model and type of tyres. The determination of the exact dimensions of the roadblocks and application of the ADIS 16385 system for acquisition and archiving the features of the kinematic motion of the vehicle allowed to determine the speed at the moment of collision with the roadblock.

  9. Medical chilling device designed for hypothermic hydration graft storage system: Design, thermohydrodynamic modeling, and preliminary testing

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Jung Hwan [Hongik University, Seoul (Korea, Republic of)

    2015-02-15

    Hypothermic hydration graft storage is essential to reduce the metabolic demand of cells in vitro. The alleviated metabolic demands reduce the emergence rate of anaerobic metabolism generating adenosine triphosphate (ATP) energy that creates free radicals. The cessive free radicals can damage cells and tissues due to their highly oxidative power with molecules. Current cooling systems such as a conventional air cooling system and an ice pack system are inappropriate for chilling cell tissues in vitro because of inconvenience in use and inconsistent temperature sustainability caused by large size and progressive melting, respectively. Here, we develop a medical chilling device (MCD) for hypothermic hydration graft storage based on thermo-hydrodynamic modeling and thermal electric cooling technology. Our analysis of obtained hydrodynamic thermal behavior of the MCD revealed that the hypothermic condition of 4 .deg. C was continuously maintained, which increased the survival rates of cells in vitro test by reduced free radicals. The validated performance of the MCD promises future development of an optimal hypothermic hydration graft storage system designed for clinical use.

  10. User attitudes in analyzing digital slides in a quality control test bed: a preliminary study.

    Science.gov (United States)

    Della Mea, Vincenzo; Demichelis, Francesca; Viel, Federico; Dalla Palma, Paolo; Beltrami, Carlo Alberto

    2006-05-01

    The pathologist examines suitably stained glass slides through a bright field microscope in order to render histopathological or cytological diagnosis by looking at tissues and cells. Glass slides serve as a permanent record of the patient disease. Over the course of a patient's treatment slides may need to be reviewed at other institutions before treatment can commence. Due to their fragile nature a transportable permanent digital facsimile of the glass slide would be ideal. A digital slide is a set of digital images representing the whole slide normally used by the pathologist, or a significant part of it; it is usually made by a large amount of images, up to thousands, which makes its management difficult. The present paper provides a description of the requirements needed to reproduce glass slides and of the available technological equipment, then the features of the two systems we implemented on different hardware are described, together with those of the digital slide viewer. The viewer was evaluated in two experimental test phases, during which user behaviour and diagnostic reports were measured. Digital slides used in the two experiments were acquired with either system. Possible applications of digital slides are then discussed, including undergraduate and professional education, quality control, and image analysis on full samples as well as on tissue microarrays.

  11. Test and Sensitivity Analysis of Hydrological Modeling in the Coupled WRF-Urban Modeling System

    Science.gov (United States)

    Wang, Z.; yang, J.

    2013-12-01

    Rapid urbanization has emerged as the source of many adverse effects that challenge the environmental sustainability of cities under changing climatic patterns. One essential key to address these challenges is to physically resolve the dynamics of urban-land-atmospheric interactions. To investigate the impact of urbanization on regional climate, physically-based single layer urban canopy model (SLUCM) has been developed and implemented into the Weather Research and Forecasting (WRF) platform. However, due to the lack of realistic representation of urban hydrological processes, simulation of urban climatology by current coupled WRF-SLUCM is inevitably inadequate. Aiming at improving the accuracy of simulations, recently we implemented urban hydrological processes into the model, including (1) anthropogenic latent heat, (2) urban irrigation, (3) evaporation over impervious surface, and (4) urban oasis effect. In addition, we couple the green roof system into the model to verify its capacity in alleviating urban heat island effect at regional scale. Driven by different meteorological forcings, offline tests show that the enhanced model is more accurate in predicting turbulent fluxes arising from built terrains. Though the coupled WRF-SLUCM has been extensively tested against various field measurement datasets, accurate input parameter space needs to be specified for good model performance. As realistic measurements of all input parameters to the modeling framework are rarely possible, understanding the model sensitivity to individual parameters is essential to determine the relative importance of parameter uncertainty to model performance. Thus we further use an advanced Monte Carlo approach to quantify relative sensitivity of input parameters of the hydrological model. In particular, performance of two widely used soil hydraulic models, namely the van Genuchten model (based on generic soil physics) and an empirical model (viz. the CHC model currently adopted in WRF

  12. An extremely sensitive species-specific ARMs PCR test for the presence of tiger bone DNA.

    Science.gov (United States)

    Wetton, Jon H; Tsang, Carol S F; Roney, Chris A; Spriggs, Adrian C

    2004-02-10

    The survival of the tiger (Panthera tigris) is seriously threatened by poaching to provide raw materials for Traditional Chinese Medicines (TCMs). Most highly prized are the tiger's bones, which are used in combination with other animal and plant derivatives in pills and plasters for the treatment of rheumatism and other ailments. Hundreds of patent remedies have been produced which claim to contain tiger bone, but proof of its presence is needed, if legislation prohibiting the trade in endangered species is to be enforced. A highly sensitive tiger-specific real-time PCR assay has been developed to address this problem. Using primers specific to the tiger mitochondrial cytochrome b gene, successful amplification has been reliably achieved from blood, hair and bone as well as from a range of TCMs spiked with 0.5% tiger bone. Although capable of detecting fewer than 10 substrate molecules, the seven varieties of TCM pills and plasters tested showed no detectable trace of tiger DNA before spiking. Furthermore, sequencing several "tiger bone" fragments seized from TCM shops has shown that they actually originated from cattle and pigs. The potential effects of traditional bone preparation methods, evidence that much lower concentrations are used than alleged on TCM packaging, and substitution of bones from other species all suggest a low likelihood of detecting tiger DNA in patent medicines. Despite this, the basic methods have been thoroughly proven and can be readily applied to derivatives from other CITES protected species providing a rapid and highly sensitive forensic test for species of origin. Potential applications to the monitoring of wild populations are demonstrated by the successful identification of shed hairs and faecal samples.

  13. Assessing speech perception in Swedish school-aged children: preliminary data on the Listen-Say test.

    Science.gov (United States)

    Nakeva von Mentzer, Cecilia; Sundström, Martina; Enqvist, Karin; Hällgren, Mathias

    2017-10-10

    To meet the need for a linguistic speech perception test in Swedish, the 'Listen-Say test' was developed. Minimal word pairs were used as speech material to assess seven phonetic contrasts in two auditory backgrounds. In the present study, children's speech discrimination skills in quiet and in four-talker (4T) speech background were examined. Associations with lexical-access skills and academic achievement were explored. The study included 27 school children 7-9 years of age. Overall, the children discriminated phonetic contrasts well in both conditions (quiet: Mdn 95%; 4T speech; Mdn 91% correct). A significant effect of 4T speech background was evident in three of the contrasts, connected to place of articulation, voicing and syllable complexity. Reaction times for correctly identified target words were significantly longer in the quiet condition, possibly reflecting a need for further balancing of the test order. Overall speech discrimination accuracy was moderately to highly correlated with lexical-access ability. Children identified as having high concentration ability by their teacher had the highest speech discrimination scores in both conditions followed by children identified as having high reading ability. The first wave of data collection with the Listen-Say test indicates that the test appears to be sensitive to predicted perceptual difficulties of phonetic contrasts particularly in noise. The clinical benefit of using a procedure where speech discrimination, lexical-access ability and academic achievement are taken into account is discussed as well as issues for further test refinement.

  14. Preliminary testing of a compact bone-attached robot for otologic surgery

    Science.gov (United States)

    Dillon, Neal P.; Balachandran, Ramya; Motte dit Falisse, Antoine; Wanna, George B.; Labadie, Robert F.; Withrow, Thomas J.; Fitzpatrick, J. Michael; Webster, Robert J.

    2014-03-01

    Otologic surgery often involves a mastoidectomy procedure, in which part of the temporal bone is milled away in order to visualize critical structures embedded in the bone and safely access the middle and inner ear. We propose to automate this portion of the surgery using a compact, bone-attached milling robot. A high level of accuracy is required t o avoid damage to vital anatomy along the surgical path, most notably the facial nerve, making this procedure well-suited for robotic intervention. In this study, several of the design considerations are discussed and a robot design and prototype are presented. The prototype is a 4 degrees-of-freedom robot similar to a four-axis milling machine that mounts to the patient's skull. A positioning frame, containing fiducial markers and attachment points for the robot, is rigidly attached to the skull of the patient, and a CT scan is acquired. The target bone volume is manually segmented in the CT by the surgeon and automatically converted to a milling path and robot trajectory. The robot is then attached to the positioning frame and is used to drill the desired volume. The accuracy of the entire system (image processing, planning, robot) was evaluated at several critical locations within or near the target bone volume with a mean free space accuracy result of 0.50 mm or less at all points. A milling test in a phantom material was then performed to evaluate the surgical workflow. The resulting milled volume did not violate any critical structures.

  15. Partial Nucleate Pool Boiling at Low Heat Flux: Preliminary Ground Test for SOBER-SJ10

    Science.gov (United States)

    Wu, Ke; Li, Zhen-Dong; Zhao, Jian-Fu; Li, Hui-Xiong; Li, Kai

    2016-05-01

    Focusing on partial nucleate pool boiling at low heat flux, SOBER-SJ10, one of 27 experiments of the program SJ-10, has been proposed to study local convection and heat transfer around an isolated growing vapor bubble during nucleate pool boiling on a well characterized flat surface in microgravity. An integrated micro heater has been developed. By using a local pulse overheating method in the experimental mode of single bubble boiling, a bubble nucleus can be excited with accurate spatial and temporal positioning on the top-side of a quartz glass substrate with a thickness of 2 mm and an effective heating area of 4.5 mm in diameter, and then grows under an approximate constant heat input provided by the main heater on the back-side of the substrate. Ten thin film micro-RTDs are used for local temperature measurements on the heating surface underneath the growing bubble. Normal pool boiling experiments can also be carried out with step-by-step increase of heating voltage. A series of ground test of the flight module of SOBER-SJ10 have been conducted. Good agreement of the measured data of single phase natural convection with the common-used empirical correlation warrants reasonable confidence in the data. It is found that the values of the incipience superheat of pool boiling at different subcooling are consistent with each others, verifying that the influence of subcooling on boiling incipience can be neglected. Pool boiling curves are also obtained, which shows great influence of subcooling on heat transfer of partial nucleate pool boiling, particularly in lower heat flux.

  16. Brazilian Portuguese adaptation of Dyslexia Early Screening Test - Second edition: preliminary findings.

    Science.gov (United States)

    Matta, Tatiana Ribeiro Gomes da; Befi-Lopes, Debora Maria

    2015-01-01

    The assessment of language skills in early childhood can provide important information about the future of literacy and academic performances. Children with reading difficulties should be identified early in their education, before they suffer from shortcomings and experience failures and feel discouraged at school. Considering the importance of early identification of language disorders and the shortage of standardized instruments for the Brazilian scenario, the overall objective of this study was to translate and adapt the Dyslexia Early Screening Test - Second Edition (DEST-2) to, subsequently, verify its applicability and efficacy in preschoolers who had Brazilian Portuguese as their native language. The study was composed of 20 children of both genders, regularly enrolled in a public school in the metropolitan region of São Paulo, none had any complaints related to learning and no indicators of sensory, neurological, cognitive, or behavioral disorders. It was observed that there was no need for significant changes to the original structure of the DEST-2 or in their administration instructions format. The performance of the children in the translated and in the national exams that were used as a benchmark was compatible, suggesting that the adjustments made met the equivalences needed to utilize this instrument with Brazilian children. A randomized study that will complement the preliminarily data obtained is in progress. Taking into consideration the linguistic and cultural diversity of Brazil, it is imperative that the translated version of the DEST-2 can be applied on a large scale and in several states of the country, in order to allow the use of this instrument as a language assessment tool in Brazil.

  17. Balance impairment in people with multiple sclerosis: preliminary evidence for the Balance Evaluation Systems Test.

    Science.gov (United States)

    Jacobs, Jesse V; Kasser, Susan L

    2012-07-01

    This study examined the validity of the Balance Evaluation Systems Test (BESTest) to identify balance impairments in people with multiple sclerosis (MS) by evaluating differences in BESTest performance between people with and without MS. We also assessed the BESTest's validity by correlation with objective measures of postural performance as well as with disease severity and fall status. Thirteen subjects with MS (Expanded Disability Status Scale; EDSS: 0-4.5) and 13 matched subjects without MS were evaluated on the BESTest, asked about fall history, and assessed by force plates and motion capture as they performed laboratory tasks of step initiation, forward leaning to the limits of stability, and postural responses to rotations of the support surface. Compared to subjects without MS, subjects with MS exhibited lower total BESTest scores (mean (95%) score for subjects with MS=91 (83-99); subjects without MS=105 (104-107)) as well as section scores pertaining to mechanical constraints, limits of stability, anticipatory postural adjustments, and gait. BESTest scores significantly correlated with objective laboratory measures of step velocity during step initiation (Pearson r(2)=0.48, P<0.01) as well as center-of-pressure displacements during both the leaning (Pearson r(2)=0.55, P<0.005) and postural-response tasks (Pearson r(2)=0.76, P<0.0001). BESTest total scores were 92% accurate to identify fallers and non-fallers, and BESTest scores significantly correlated with EDSS scores (Spearman's rho=0.85, P<0.0005). Thus, the BESTest provides a valid clinical assessment of balance impairments in people with MS.

  18. Hypoalgesia after exercise and the cold pressor test is reduced in chronic musculuskeletal pain patients with high pain sensitivity

    DEFF Research Database (Denmark)

    Vægter, Henrik Bjarke; Handberg, Gitte; Graven-Nielsen, Thomas

    2016-01-01

    OBJECTIVES: In chronic pain patients, impaired conditioned pain modulation (CPM) and exercise-induced hypoalgesia (EIH) have been reported. No studies have compared CPM and EIH in chronic musculoskeletal pain patients with high pain sensitivity (HPS) and low pain sensitivity (LPS). MATERIALS.......005). Pain tolerance increased after the cold pressor test and exercise in both groups (PCPM and EIH were partly impaired in chronic pain patients with high versus less pain sensitivity, suggesting that the CPM and EIH responses depend on the degree of pain sensitivity. This has clinical...

  19. Validation of the cross-linguistic naming test: a naming test for different cultures? A preliminary study in the Spanish population.

    Science.gov (United States)

    Gálvez-Lara, Mario; Moriana, Juan Antonio; Vilar-López, Raquel; Fasfous, Ahmed Fayez; Hidalgo-Ruzzante, Natalia; Pérez-García, Miguel

    2015-01-01

    Despite the consensus pointing out the importance of cultural variables in neuropsychological assessments, empirical studies within cross-cultural neuropsychology continue to be limited. The Cross-Linguistic Naming Test (CLNT) is a naming test that is supposed to have no influence from cultural variables. The aim of this paper is to determine the psychometric properties of the CLNT and its discriminatory validity (Experiment 1) and to determine the performance of the CLNT in different cultures (Experiment 2). Three groups followed the CLNT in Experiment 1: dementia patients, individuals with subjective memory complaints, and neurologically healthy volunteers. Three groups followed the CLNT in Experiment 2: Colombians, Moroccans, and Spaniards. The results showed that the psychometric properties of the CLNT are appropriate and that this test obtains a high specificity but a low sensitivity. Furthermore, no differences were found in the CLNT among the three cultural groups. The CLNT may be appropriate for the screening of naming impairment in Colombian, Moroccan, and Spanish cultures.

  20. Speech and pause characteristics in multiple sclerosis: A preliminary study of speakers with high and low neuropsychological test performance

    Science.gov (United States)

    FEENAUGHTY, LYNDA; TJADEN, KRIS; BENEDICT, RALPH H.B.; WEINSTOCK-GUTTMAN, BIANCA

    2017-01-01

    This preliminary study investigated how cognitive-linguistic status in multiple sclerosis (MS) is reflected in two speech tasks (i.e. oral reading, narrative) that differ in cognitive-linguistic demand. Twenty individuals with MS were selected to comprise High and Low performance groups based on clinical tests of executive function and information processing speed and efficiency. Ten healthy controls were included for comparison. Speech samples were audio-recorded and measures of global speech timing were obtained. Results indicated predicted differences in global speech timing (i.e. speech rate and pause characteristics) for speech tasks differing in cognitive-linguistic demand, but the magnitude of these task-related differences was similar for all speaker groups. Findings suggest that assumptions concerning the cognitive-linguistic demands of reading aloud as compared to spontaneous speech may need to be re-considered for individuals with cognitive impairment. Qualitative trends suggest that additional studies investigating the association between cognitive-linguistic and speech motor variables in MS are warranted. PMID:23294227

  1. Performance characteristics of selected immunoassays for preliminary test of 3,4-methylenedioxymethamphetamine, methamphetamine, and related drugs in urine specimens.

    Science.gov (United States)

    Hsu, Jui; Liu, Chiareiy; Liu, C P; Tsay, Wen-Ing; Li, Jih-Heng; Lin, Dong-Liang; Liu, Ray H

    2003-10-01

    Eight commercially available immunoassays for amphetamines (DRI Amphetamines, CEDIA DAU Amphetamines-Semiquantitative, EMIT d.a.u. Monoclonal Amphetamine/Methamphetamine, Synchron CX Systems AMPH, TDx/TDxFLx Amphetamine/Methamphetamine II, CEDIA Amphetamines/Ecstasy, COBAS INTEGRA Amphetamines, and Abuscreen((R)) OnLine HS Amphetamine/MDMA) are evaluated for their effectiveness in serving as the preliminary test methodology for the analysis of 3,4-methylenedioxymethamphetamine/3,4-methylenedioxyamphetamine (MDMA/MDA) and methamphetamine/amphetamine (MA/AM). Standard solutions (in urine matrix) of MDMA, MDA, MA, and AM are used to determine these immunoassays' reactivities (or cross-reactivities) toward these compounds of interest. Case specimens containing MDMA/MDA and MA/AM are also used to study the correlations of the apparent immunoassay MDMA (or MA) concentrations and the gas chromatographic-mass spectrometric concentrations of these compounds. Data resulting from this study suggest that CEDIA Amphetamines/Ecstasy can best predict the concentrations of MDMA and MA in case specimens and can also detect the presence of MDMA at low levels, whereas Abuscreen OnLine HS Amphetamine/MDMA can detect both MDMA and MA at low concentrations.

  2. Preliminary Testing of a Patient-Reported Outcome Measure for Recurrent or Metastatic Head and Neck Cancer.

    Science.gov (United States)

    Jackson, Leanne K; Deng, Jie; Ridner, Sheila H; Gilbert, Jill; Dietrich, Mary S; Murphy, Barbara A

    2016-05-01

    We describe development and preliminary testing of Vanderbilt Head and Neck Symptom Survey-Recurrent/Metastatic (VHNSS-RM) to assess residual symptoms, tumor-related symptoms, and side effects from therapy. Items were identified through patient and provider interviews. Card sort selected high-yield and high-impact items. The VHNSS-RM was administered to 50 patients with recurrent/metastatic head and neck cancer (RMHNC). The VHNSS-RM includes 12 unique symptoms (diet change, tongue movement affecting speech/swallowing, face/neck swelling, neck/jaw cramping, bad breath, drooling, wound drainage/pain/odor, nasal congestion/drainage, eyes watering, face/tongue/ear/scalp numbness, headaches, and confusion) and 7 unique psychosocial issues (burden to family/friends, lost independence, fear, embarrassment, mood swings, stress, and boredom). The VHNSS-RM contains 35 physical and 12 psychosocial issues. The VHNSS-RM is feasible and not overly burdensome. Nineteen unique items may improve palliation to patients with RMHNC. © The Author(s) 2015.

  3. A Preliminary Test of the Interpersonal-Psychological Theory of Suicide in Women Seeking Shelter From Intimate Partner Violence.

    Science.gov (United States)

    Wolford-Clevenger, Caitlin; Smith, Phillip N; Kuhlman, Shane; D'Amato, Darcey

    2016-07-25

    Women seeking shelter from intimate partner violence (IPV) are at greater risk of suicide ideation and attempts compared with women in the general population. A theoretically grounded understanding of suicide risk in shelter-seeking women is critical to improve assessment and management of suicide risk in this population. The interpersonal-psychological theory of suicide (IPTS) proposes that suicide ideation results from hopelessness about thwarted belongingness and perceived burdensomeness. However, suicide ideation does not progress to death by suicide unless one has acquired the capability for suicide (i.e., pain tolerance and fearlessness about death) via repeated exposure to painful and fearsome events. The present study provides a preliminary test of the IPTS in a sample of 134 women seeking shelter from IPV. First, we examined factors theoretically related to suicide ideation, demonstrating that only at high levels of hopelessness was perceived burdensomeness associated with suicide ideation. The study also examined factors theoretically related to the acquired capability for suicide (ACS), indicating that physical partner violence perpetration was associated with ACS. These findings suggest that perceived burdensomeness, particularly in the context of increased hopelessness, is important in the assessment and treatment of suicide ideation. Furthermore, violence perpetration may indicate greater risk of the capability to die by suicide among women seeking shelter from IPV. © The Author(s) 2016.

  4. Preliminary PINC(Program for the Inspection of Nickel Alloy Components) RRT(Round Robin Test) - Pressurizer Dissimilar Metal Weld

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kyung Cho; Kang, Sung Sik; Shin, Ho Sang; Chung, Ku Kab; Song, Myung Ho; Chung, Hae Dong [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2009-06-15

    After several damages by PWSCC were found in the world, USNRC and PNNL(Pacific Northwest National Laboratory) started the research on PWSCC under the project name of PINC. The aim of the project was 1) to fabricate representative NDE mock-ups with flaws to simulate PWSCCs, 2) to identify and quantitatively assess NDE methods for accurately detecting, sizing and characterizing PWSCCs, 3) to document the range of locations and morphologies of PWSCCs and 4) to incorporate results with other results of ongoing PWSCC research programs, as appropriate. Korea nuclear industries have also been participating in the project. Thermally and mechanically cracked-four mockups were prepared and phased array and manual ultrasonic testing(UT) techniques were applied. The results and lessons learned from the preliminary RRT are summarized as follows: 1) Korea RRT teams performed the RRT successfully. 2) Crack detection probability of the participating organizations was an average 87%, 80% and 80% respectively. 3) RMS error of the crack sizing showed comparatively good results. 4) The lessons learned may be helpful to perform the PINC RRT and PSI /ISI in Korea in the future.

  5. Posttraumatic stress symptoms and body mass index among World Trade Center disaster-exposed smokers: A preliminary examination of the role of anxiety sensitivity.

    Science.gov (United States)

    Farris, Samantha G; Paulus, Daniel J; Gonzalez, Adam; Mahaffey, Brittain L; Bromet, Evelyn J; Luft, Benjamin J; Kotov, Roman; Zvolensky, Michael J

    2016-07-30

    Among individuals exposed to the World Trade Center (WTC) disaster on September 11, 2001, posttraumatic stress disorder (PTSD) and symptoms are both common and associated with increased cigarette smoking and body mass. However, there is little information on the specific processes underlying the relationship of PTSD symptoms with body mass. The current study is an initial exploratory test of anxiety sensitivity, the fear of internal bodily sensations, as a possible mechanism linking PTSD symptom severity and body mass index (BMI). Participants were 147 adult daily smokers (34.0% female) exposed to the WTC disaster (via rescue/recovery work or direct witness). The direct and indirect associations between PTSD symptom severity and BMI via anxiety sensitivity (total score and subscales of physical, cognitive, and social concerns) were examined. PTSD symptom severity was related to BMI indirectly via anxiety sensitivity; this effect was specific to physical concerns about the meaning of bodily sensations. Interventions focusing on anxiety sensitivity reduction (specifically addressing physical concerns about bodily sensations) may be useful in addressing elevated BMI among trauma-exposed persons.

  6. Application of KRL test to assess total antioxidant activity in pigs: sensitivity to dietary antioxidants.

    Science.gov (United States)

    Rossi, Raffaella; Pastorelli, Grazia; Corino, Carlo

    2013-04-01

    The application of Kit Radicaux Libres (KRL) test to assess total blood antioxidant activity in pigs was evaluated. The KRL has been validated and is widely used in humans for assessing the effectiveness of natural or pharmaceutical treatments, and in vitro to evaluate the antioxidant activities of natural or synthetic antioxidants. In this study the sensitivity of the KRL test in assessing the effectiveness of dietary antioxidant supplementation (vitamin E and plant extract) was evaluated in two different phases of pig breeding. The first trial, in post-weaned piglets (40 piglets/group) fed dietary vitamin E supplementation for 60 days, indicated that there was a higher total antioxidant activity (P=0.032) of whole blood and of red blood cells (P=0.001) than for control pigs. The second trial indicated that long-term supplementation of water soluble plant extract (20 pigs/group) from the leaves of Verbenaceae (Lippia spp.) tended (P=0.091) to increase antioxidant activity in the whole blood of treated, rather than control pigs. These results indicate that the KRL might be recommended as one of efficient means for evaluating antioxidant activity of dietary ingredients fed to pigs.

  7. Sensitivity of Cirrus Simulations in Idealized Situations: The WG2 Test Cases

    Science.gov (United States)

    Starr, David OC.

    1998-01-01

    GCSS Cirrus Cloud Systems Working Group (WG2) is presently conducting a comparison of cirrus cloud models for idealized initial conditions. The experiments involve binary (off/on) tests of model sensitivity to infrared radiative processes, and thermal stratification, and vertical wind shear for situations of weakly forced (3 cm/s uplift) cold (-60 to -70 C) and warm (-35 to -50 C) cirrus clouds. A range of model types are involved including parcel, SCM, 2-D CRM, 3-D CRM and LES models. The test cases will be described and results from 2-dimensional cirrus cloud models with bulk microphysics (implicit second moment scheme) and explicit bin microphysics will be compared. Vertical ice mass flux (particle fall speed) is a critical model component leading to significant intermodel differences. Efforts are ongoing to better quantify this aspect. Future plans of WG2 will also be briefly described and include model comparisons for a well-observed case of cold (ARM IOP) cirrus and of warm (EUCREX) cirrus, as well as, a joint activity with WG4 to consider the treatment of anvil cirrus in a variety of models.

  8. A novel flow cytometric hemozoin detection assay for real-time sensitivity testing of Plasmodium falciparum.

    Directory of Open Access Journals (Sweden)

    Maria Rebelo

    Full Text Available Resistance of Plasmodium falciparum to almost all antimalarial drugs, including the first-line treatment with artemisinins, has been described, representing an obvious threat to malaria control. In vitro antimalarial sensitivity testing is crucial to detect and monitor drug resistance. Current assays have been successfully used to detect drug effects on parasites. However, they have some limitations, such as the use of radioactive or expensive reagents or long incubation times. Here we describe a novel assay to detect antimalarial drug effects, based on flow cytometric detection of hemozoin (Hz, which is rapid and does not require any additional reagents. Hz is an optimal parasite maturation indicator since its amount increases as the parasite matures. Due to its physical property of birefringence, Hz depolarizes light, hence it can be detected using optical methods such as flow cytometry. A common flow cytometer was adapted to detect light depolarization caused by Hz. Synchronized in vitro cultures of P. falciparum were incubated for 48 hours with several antimalarial drugs. Analysis of depolarizing events, corresponding to parasitized red blood cells containing Hz, allowed the detection of parasite maturation. Moreover, chloroquine resistance and the inhibitory effect of all antimalarial drugs tested, except for pyrimethamine, could be determined as early as 18 to 24 hours of incubation. At 24 hours incubation, 50% inhibitory concentrations (IC50 were comparable to previously reported values. These results indicate that the reagent-free, real-time Hz detection assay could become a novel assay for the detection of drug effects on Plasmodium falciparum.

  9. Lagrangian model of zooplankton dispersion: numerical schemes comparisons and parameter sensitivity tests

    Institute of Scientific and Technical Information of China (English)

    QIU Zhongfeng; Andrea M. DOGLIOLI; HE Yijun; Francois CARLOTTI

    2011-01-01

    This paper presents two comparisons or tests for a Lagrangian model of zooplankton dispersion: numerical schemes and time steps. Firstly, we compared three numerical schemes using idealized circulations. Results show that the precisions of the advanced Adams-Bashfold-Moulton (ABM) method and the Runge-Kutta (RK) method were in the same order and both were much higher than that of the Euler method. Furthermore, the advanced ABM method is more efficient than the RK method in computational memory requirements and time consumption. We therefore chose the advanced ABM method as the Lagrangian particle-tracking algorithm. Secondly, we performed a sensitivity test for time steps, using outputs of the hydrodynamic model, Symphonie. Results show that the time step choices depend on the fluid response time that is related to the spatial resolution of velocity fields. The method introduced by Oliveira et al. in 2002 is suitable for choosing time steps of Lagrangian particle-tracking models, at least when only considering advection.

  10. Buckling Test Results and Preliminary Test and Analysis Correlation from the 8-Foot-Diameter Orthogrid-Stiffened Cylinder Test Article TA02

    Science.gov (United States)

    Hilburger, Mark W.; Waters, W. Allen, Jr.; Haynie, Waddy T.; Thornburgh, Robert P

    2017-01-01

    Results from the testing of cylinder test article SBKF-P2-CYL-TA02 (referred to herein as TA02) are presented. TA02 is an 8-foot-diameter (96-inches), 78.0-inch-long, aluminum-lithium (Al-Li), orthogrid-stiffened cylindrical shell similar to those used in current state-of-the-art launch-vehicle structures and was designed to exhibit global buckling when subjected to combined compression and bending loads. The testing was conducted at the Marshall Space Flight Center (MSFC), February 3-6, 2009, in support of the Shell Buckling Knockdown Factor Project (SBKF). The test was used to verify the performance of a newly constructed buckling test facility at MSFC and to verify the test article design and analysis approach used by the SBKF researchers.

  11. Bayesian estimation of sensitivity and specificity of Coxiella burnetii antibody ELISA tests in bovine blood and milk

    DEFF Research Database (Denmark)

    Paul, Suman; Toft, Nils; Agerholm, Jørgen S.;

    2013-01-01

    Serological tests for Coxiella burnetii (the causative agent of Q fever) antibodies are usually based on enzyme linked immunosorbent assay (ELISA) although this method is not thoroughly evaluated. The objective of this study was to determine the sensitivity and specificity of an ELISA for detection...... of the ELISA methods on milk and blood were equal at 0.99. No conditional dependence was observed between the specificity estimates of the two test methods. However, the sensitivity estimates of both tests were significantly reduced when conditional covariances ≥40 were used. Collection of milk samples from...... to positive (S/P) cut-off of 40 for both blood and milk ELISAs. At this cut-off, sensitivity of milk ELISA was 0.86 (95% posterior credibility interval [PCI] [0.76; 0.96]). This was slightly but insignificantly higher than sensitivity of blood ELISA (0.84; 95% PCI [0.75; 0.93]). The specificity estimates...

  12. The Detection and Influence of Problematic Item Content in Ability Tests: An Examination of Sensitivity Review Practices for Personnel Selection Test Development

    Science.gov (United States)

    Grand, James A.; Golubovich, Juliya; Ryan, Ann Marie; Schmitt, Neal

    2013-01-01

    In organizational and educational practices, sensitivity reviews are commonly advocated techniques for reducing test bias and enhancing fairness. In the present paper, results from two studies are reported which investigate how effective individuals are at detecting problematic test content and the influence such content has on important testing…

  13. Serial High-Sensitivity Troponin T in Post-Primary Angioplasty Exercise Test

    Directory of Open Access Journals (Sweden)

    Humberto Andres Vaz

    2016-04-01

    Full Text Available Abstract Background: The kinetics of high-sensitivity troponin T (hscTnT release should be studied in different situations, including functional tests with transient ischemic abnormalities. Objective: To evaluate the release of hscTnT by serial measurements after exercise testing (ET, and to correlate hscTnT elevations with abnormalities suggestive of ischemia. Methods: Patients with acute ST-segment elevation myocardial infarction (STEMI undergoing primary angioplasty were referred for ET 3 months after infarction. Blood samples were collected to measure basal hscTnT immediately before (TnT0h, 2 (TnT2h, 5 (TnT5h, and 8 hours (TnT8h after ET. The outcomes were peak hscTnT, TnT5h/TnT0h ratio, and the area under the blood concentration-time curve (AUC for hscTnT levels. Log-transformation was performed on hscTnT values, and comparisons were assessed with the geometric mean ratio, along with their 95% confidence intervals. Statistical significance was assessed by analysis of covariance with no adjustment, and then, adjusted for TnT0h, age and sex, followed by additional variables (metabolic equivalents, maximum heart rate achieved, anterior wall STEMI, and creatinine clearance. Results: This study included 95 patients. The highest geometric means were observed at 5 hours (TnT5h. After adjustments, peak hscTnT, TnT5h/TnT0h and AUC were 59% (p = 0.002, 59% (p = 0.003 and 45% (p = 0.003 higher, respectively, in patients with an abnormal ET as compared to those with normal tests. Conclusion: Higher elevations of hscTnT may occur after an abnormal ET as compared to a normal ET in patients with STEMI.

  14. Serial High-Sensitivity Troponin T in Post-Primary Angioplasty Exercise Test

    Science.gov (United States)

    Vaz, Humberto Andres; Vanz, Ana Paula; Castro, Iran

    2016-01-01

    Background The kinetics of high-sensitivity troponin T (hscTnT) release should be studied in different situations, including functional tests with transient ischemic abnormalities. Objective To evaluate the release of hscTnT by serial measurements after exercise testing (ET), and to correlate hscTnT elevations with abnormalities suggestive of ischemia. Methods Patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary angioplasty were referred for ET 3 months after infarction. Blood samples were collected to measure basal hscTnT immediately before (TnT0h), 2 (TnT2h), 5 (TnT5h), and 8 hours (TnT8h) after ET. The outcomes were peak hscTnT, TnT5h/TnT0h ratio, and the area under the blood concentration-time curve (AUC) for hscTnT levels. Log-transformation was performed on hscTnT values, and comparisons were assessed with the geometric mean ratio, along with their 95% confidence intervals. Statistical significance was assessed by analysis of covariance with no adjustment, and then, adjusted for TnT0h, age and sex, followed by additional variables (metabolic equivalents, maximum heart rate achieved, anterior wall STEMI, and creatinine clearance). Results This study included 95 patients. The highest geometric means were observed at 5 hours (TnT5h). After adjustments, peak hscTnT, TnT5h/TnT0h and AUC were 59% (p = 0.002), 59% (p = 0.003) and 45% (p = 0.003) higher, respectively, in patients with an abnormal ET as compared to those with normal tests. Conclusion Higher elevations of hscTnT may occur after an abnormal ET as compared to a normal ET in patients with STEMI. PMID:26959404

  15. Serial High-Sensitivity Troponin T in Post-Primary Angioplasty Exercise Test

    Energy Technology Data Exchange (ETDEWEB)

    Vaz, Humberto Andres, E-mail: humbertovaz@cardiol.br; Vanz, Ana Paula; Castro, Iran [Instituto de Cardiologia - Fundação Universitária de Cardiologia, Porto Alegre, RS (Brazil)

    2016-04-15

    The kinetics of high-sensitivity troponin T (hscTnT) release should be studied in different situations, including functional tests with transient ischemic abnormalities. To evaluate the release of hscTnT by serial measurements after exercise testing (ET), and to correlate hscTnT elevations with abnormalities suggestive of ischemia. Patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary angioplasty were referred for ET 3 months after infarction. Blood samples were collected to measure basal hscTnT immediately before (TnT{sub 0h}), 2 (TnT{sub 2h}), 5 (TnT{sub 5h}), and 8 hours (TnT{sub 8h}) after ET. The outcomes were peak hscTnT, TnT{sub 5h}/TnT{sub 0h} ratio, and the area under the blood concentration-time curve (AUC) for hscTnT levels. Log-transformation was performed on hscTnT values, and comparisons were assessed with the geometric mean ratio, along with their 95% confidence intervals. Statistical significance was assessed by analysis of covariance with no adjustment, and then, adjusted for TnT{sub 0h}, age and sex, followed by additional variables (metabolic equivalents, maximum heart rate achieved, anterior wall STEMI, and creatinine clearance). This study included 95 patients. The highest geometric means were observed at 5 hours (TnT{sub 5h}). After adjustments, peak hscTnT, TnT{sub 5h}/TnT{sub 0h} and AUC were 59% (p = 0.002), 59% (p = 0.003) and 45% (p = 0.003) higher, respectively, in patients with an abnormal ET as compared to those with normal tests. Higher elevations of hscTnT may occur after an abnormal ET as compared to a normal ET in patients with STEMI.

  16. Test Your Memory is sensitive to cognitive change but lacks prospective validity.

    Science.gov (United States)

    Ferrero-Arias, J; Turrión-Rojo, M Á

    2016-03-01

    To determine the prospective validity of Test Your Memory (TYM) and its sensitivity to change in cognitive state. This longitudinal prospective study followed 71 patients with subjective cognitive symptoms and 48 with mild cognitive impairment for a mean time period of 35.2 ± 15 months. Subjects did not have dementia or depression at the beginning of follow-up and each participant was given the TYM at least two times. A psychometric threshold was established to determine presence of a cognitive deficit (z-score ≤ 1.5 on at least one cognitive domain) and the Disability Assessment for Dementia scale was used to ensure full functional ability. The criterion for deterioration was a change in the stage on the Global Deterioration Scale. Sixty-one patients remained cognitively stable and 58 worsened. There were no differences between them with respect to sex, educational attainment, the initial stage on the GDS, or the score on the first TYM. Subjects who worsened were older than those who did not. The TYM increased an average of 0.04 points per month in patients who remained stable or improved (95% CI, -0.01 to 0.08) and decreased an average of 0.14 points per month in those whose condition worsened (95% CI, -0.19 to -0.09). Subjects with mild cognitive impairment who worsened displayed a sharper loss of TYM points than did subjects with subjective cognitive symptoms. While the TYM lacks prospective validity, it is sensitive to changes in cognitive state. Copyright © 2015 Sociedad Española de Neurología. Published by Elsevier España, S.L.U. All rights reserved.

  17. Sensitivity of wetland methane emissions to model assumptions: application and model testing against site observations

    Directory of Open Access Journals (Sweden)

    L. Meng

    2012-07-01

    Full Text Available Methane emissions from natural wetlands and rice paddies constitute a large proportion of atmospheric methane, but the magnitude and year-to-year variation of these methane sources are still unpredictable. Here we describe and evaluate the integration of a methane biogeochemical model (CLM4Me; Riley et al., 2011 into the Community Land Model 4.0 (CLM4CN in order to better explain spatial and temporal variations in methane emissions. We test new functions for soil pH and redox potential that impact microbial methane production in soils. We also constrain aerenchyma in plants in always-inundated areas in order to better represent wetland vegetation. Satellite inundated fraction is explicitly prescribed in the model, because there are large differences between simulated fractional inundation and satellite observations, and thus we do not use CLM4-simulated hydrology to predict inundated areas. A rice paddy module is also incorporated into the model, where the fraction of land used for rice production is explicitly prescribed. The model is evaluated at the site level with vegetation cover and water table prescribed from measurements. Explicit site level evaluations of simulated methane emissions are quite different than evaluating the grid-cell averaged emissions against available measurements. Using a baseline set of parameter values, our model-estimated average global wetland emissions for the period 1993–2004 were 256 Tg CH4 yr−1 (including the soil sink and rice paddy emissions in the year 2000 were 42 Tg CH4 yr−1. Tropical wetlands contributed 201 Tg CH4 yr−1, or 78% of the global wetland flux. Northern latitude (>50 N systems contributed 12 Tg CH4 yr−1. However, sensitivity studies show a large range (150–346 Tg CH4 yr−1 in predicted global methane emissions (excluding emissions from rice paddies. The large range is

  18. Gas migration in KBS-3 buffer bentonite. Sensitivity of test parameters to experimental boundary conditions

    Energy Technology Data Exchange (ETDEWEB)

    Harrington, J.F.; Horseman, S.T. [British Geological Survey, Nottingham (United Kingdom)

    2003-01-01

    In the current Swedish repository design concept, hydrogen gas can be generated inside a waste canister by anaerobic corrosion of the ferrous metal liner. If the gas generation rate exceeds the diffusion rate of gas molecules in the buffer porewater, gas will accumulate in the void-space of a canister until its pressure becomes large enough for it to enter the bentonite as a discrete gaseous phase. Three long tenn gas injection tests have been performed on cylinders of pre-compacted MX80 bentonite. Two of these tests were undertaken using a custom-designed constant volume and radial flow (CVRF) apparatus. Gas was injected at a centrally located porous filter installed in the clay before hydration. Arrangements were made for gas to flow to three independently monitored sink-filter arrays mounted around the specimen. Axial and radial total stresses and internal porewater pressures were continuously monitored. Breakthrough and peak gas pressures were substantially larger than the sum of the swelling pressure and the external porewater. The third test was performed. using an apparatus which radially constrains the specimen during gas flow. Observed sensitivity of the breakthrough and peak gas pressures to the test boundary conditions suggests that gas entry must be accompanied by dilation of the bentonite fabric. In other words, there is a tendency for the volume of the specimen to increase during this process. The experimental evidence is consistent with the flow of gas along a relatively small number of crack-like pathways which propagate through the clay as gas pressure increases. Gas entry and breakthrough under constant volume boundary conditions causes a substantial increase in the total stress and the internal porewater pressure. It is possible to determine the point at which gas enters the clay by monitoring changes in these parameters. Localisation of gas flow within multiple pathways results, in nonuniform discharge rates at the sinks. When gas injection

  19. Preliminary tests in skull pediatric phantom for dosimetry in computerized tomography; Testes preliminares em um simulador pediatrico de cranio para dosimetria em tomografia computadorizada

    Energy Technology Data Exchange (ETDEWEB)

    Martins, Elaine Wirney; Potiens, Maria da Penha de A., E-mail: elainewirney@uso.br, E-mail: mppalbu@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2014-07-01

    Computed tomography (CT) is one of the techniques in the field of radiology with striking technological advance in recent years. One reason for this was the increased number of channels associated with the increased power of the X-ray tube. These conditions allowed the equipment high speed in the acquisition of the cuts, reducing the patient exposure time essential characteristic for the increase of its use in pediatric patients. In this context, were developed a new pediatric skull simulator to analyze the results of measurements performed in laboratory and clinic beams with the objective of creation and use of diagnostic reference levels observing risks stochastic effects and assessing the reduction of absorbed doses in patients undergoing growing. Preliminary tests performed in clinical beams showed C{sub w} values: 2.525 ± 0.212 mGy for the developed simulator quoted and 3.362 ± 0.282 mGy for a simulator developed by IPEN called standard, both being between uncertainty values of 8.4% and 14.4% suggested by TRS number 457.

  20. New Exercise-Dipyridamole Combined Test for Nuclear Cardiology in Insufficient Effort: Appropriate Diagnostic Sensitivity Keeping Exercise Prognosis

    Energy Technology Data Exchange (ETDEWEB)

    Cortinas, Inés Vidal, E-mail: invi@montevideo.com.uy; Beretta, Mario; Alonso, Omar; Mut, Fernando [Departamento de Medicina Nuclear do Hospital ‘Asociación Española’, Br. Artigas 1515, Montevideo (Uruguay)

    2015-08-15

    Myocardial perfusion scintigraphy (MPS) in patients not reaching 85% of the maximum predicted heart rate (MPHR) has reduced sensitivity. In an attempt to maintain diagnostic sensitivity without losing functional exercise data, a new exercise and dipyridamole combined protocol (EDCP) was developed. Our aim was to evaluate the feasibility and safety of this protocol and to compare its diagnostic sensitivity against standard exercise and dipyridamole protocols. In patients not reaching a sufficient exercise (SE) test and with no contraindications, 0.56 mg/kg of dipyridamole were IV administered over 1 minute simultaneously with exercise, followed by 99mTc-MIBI injection. Of 155 patients, 41 had MPS with EDCP, 47 had a SE test (≥ 85% MPHR) and 67 underwent the dipyridamole alone test (DIP). They all underwent coronary angiography within 3 months. The three stress methods for diagnosis of coronary lesions had their sensitivity compared. For stenosis ≥ 70%, EDCP yielded 97% sensitivity, SE 90% and DIP 95% (p = 0.43). For lesions ≥ 50%, the sensitivities were 94%, 88% and 95%, respectively (p = 0.35). Side effects of EDCP were present in only 12% of the patients, significantly less than with DIP (p < 0.001). The proposed combined protocol is a valid and safe method that yields adequate diagnostic sensitivity, keeping exercise prognostic information in patients unable to reach target heart rate, with fewer side effects than the DIP.

  1. New Exercise-Dipyridamole Combined Test for Nuclear Cardiology in Insufficient Effort: Appropriate Diagnostic Sensitivity Keeping Exercise Prognosis

    Science.gov (United States)

    Cortinas, Inés Vidal; Beretta, Mario; Alonso, Omar; Mut, Fernando

    2015-01-01

    Background Myocardial perfusion scintigraphy (MPS) in patients not reaching 85% of the maximum predicted heart rate (MPHR) has reduced sensitivity. Objectives In an attempt to maintain diagnostic sensitivity without losing functional exercise data, a new exercise and dipyridamole combined protocol (EDCP) was developed. Our aim was to evaluate the feasibility and safety of this protocol and to compare its diagnostic sensitivity against standard exercise and dipyridamole protocols. Methods In patients not reaching a sufficient exercise (SE) test and with no contraindications, 0.56 mg/kg of dipyridamole were IV administered over 1 minute simultaneously with exercise, followed by 99mTc-MIBI injection. Results Of 155 patients, 41 had MPS with EDCP, 47 had a SE test (≥ 85% MPHR) and 67 underwent the dipyridamole alone test (DIP). They all underwent coronary angiography within 3 months. The three stress methods for diagnosis of coronary lesions had their sensitivity compared. For stenosis ≥ 70%, EDCP yielded 97% sensitivity, SE 90% and DIP 95% (p = 0.43). For lesions ≥ 50%, the sensitivities were 94%, 88% and 95%, respectively (p = 0.35). Side effects of EDCP were present in only 12% of the patients, significantly less than with DIP (p < 0.001). Conclusions The proposed combined protocol is a valid and safe method that yields adequate diagnostic sensitivity, keeping exercise prognostic information in patients unable to reach target heart rate, with fewer side effects than the DIP. PMID:26039661

  2. New Exercise-Dipyridamole Combined Test for Nuclear Cardiology in Insufficient Effort: Appropriate Diagnostic Sensitivity Keeping Exercise Prognosis

    Directory of Open Access Journals (Sweden)

    Inés Vidal Cortinas

    2015-08-01

    Full Text Available AbstractBackground:Myocardial perfusion scintigraphy (MPS in patients not reaching 85% of the maximum predicted heart rate (MPHR has reduced sensitivity.Objectives:In an attempt to maintain diagnostic sensitivity without losing functional exercise data, a new exercise and dipyridamole combined protocol (EDCP was developed. Our aim was to evaluate the feasibility and safety of this protocol and to compare its diagnostic sensitivity against standard exercise and dipyridamole protocols.Methods:In patients not reaching a sufficient exercise (SE test and with no contraindications, 0.56 mg/kg of dipyridamole were IV administered over 1 minute simultaneously with exercise, followed by 99mTc-MIBI injection.Results:Of 155 patients, 41 had MPS with EDCP, 47 had a SE test (≥ 85% MPHR and 67 underwent the dipyridamole alone test (DIP. They all underwent coronary angiography within 3 months. The three stress methods for diagnosis of coronary lesions had their sensitivity compared. For stenosis ≥ 70%, EDCP yielded 97% sensitivity, SE 90% and DIP 95% (p = 0.43. For lesions ≥ 50%, the sensitivities were 94%, 88% and 95%, respectively (p = 0.35. Side effects of EDCP were present in only 12% of the patients, significantly less than with DIP (p < 0.001.Conclusions:The proposed combined protocol is a valid and safe method that yields adequate diagnostic sensitivity, keeping exercise prognostic information in patients unable to reach target heart rate, with fewer side effects than the DIP.

  3. Genotoxicity investigation of ELF-magnetic fields in Salmonella typhimurium with the sensitive SOS-based VITOTOX test

    NARCIS (Netherlands)

    Verschaeve, Luc; Anthonissen, Roel; Grudniewska, Magda; Wudarski, Jakub; Gevaert, Lieven; Maes, Annemarie

    2011-01-01

    We performed a genotoxicity investigation of extremely low-frequency (ELF) magnetic fields (MFs, 50 Hz, 100 and 500 µT, 1 and 2 h exposure) alone and in combination with known chemical mutagens using the VITOTOX test. This test is a very sensitive reporter assay of Salmonella typhimurium bacteria ba

  4. A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests

    Science.gov (United States)

    2011-01-01

    Background Allergic contact dermatitis is an inflammatory skin disease that affects a significant proportion of the population. This disease is caused by an adverse immune response towards chemical haptens, and leads to a substantial economic burden for society. Current test of sensitizing chemicals rely on animal experimentation. New legislations on the registration and use of chemicals within pharmaceutical and cosmetic industries have stimulated significant research efforts to develop alternative, human cell-based assays for the prediction of sensitization. The aim is to replace animal experiments with in vitro tests displaying a higher predictive power. Results We have developed a novel cell-based assay for the prediction of sensitizing chemicals. By analyzing the transcriptome of the human cell line MUTZ-3 after 24 h stimulation, using 20 different sensitizing chemicals, 20 non-sensitizing chemicals and vehicle controls, we have identified a biomarker signature of 200 genes with potent discriminatory ability. Using a Support Vector Machine for supervised classification, the prediction performance of the assay revealed an area under the ROC curve of 0.98. In addition, categorizing the chemicals according to the LLNA assay, this gene signature could also predict sensitizing potency. The identified markers are involved in biological pathways with immunological relevant functions, which can shed light on the process of human sensitization. Conclusions A gene signature predicting sensitization, using a human cell line in vitro, has been identified. This simple and robust cell-based assay has the potential to completely replace or drastically reduce the utilization of test systems based on experimental animals. Being based on human biology, the assay is proposed to be more accurate for predicting sensitization in humans, than the traditional animal-based tests. PMID:21824406

  5. A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests

    Directory of Open Access Journals (Sweden)

    Albrekt Ann-Sofie

    2011-08-01

    Full Text Available Abstract Background Allergic contact dermatitis is an inflammatory skin disease that affects a significant proportion of the population. This disease is caused by an adverse immune response towards chemical haptens, and leads to a substantial economic burden for society. Current test of sensitizing chemicals rely on animal experimentation. New legislations on the registration and use of chemicals within pharmaceutical and cosmetic industries have stimulated significant research efforts to develop alternative, human cell-based assays for the prediction of sensitization. The aim is to replace animal experiments with in vitro tests displaying a higher predictive power. Results We have developed a novel cell-based assay for the prediction of sensitizing chemicals. By analyzing the transcriptome of the human cell line MUTZ-3 after 24 h stimulation, using 20 different sensitizing chemicals, 20 non-sensitizing chemicals and vehicle controls, we have identified a biomarker signature of 200 genes with potent discriminatory ability. Using a Support Vector Machine for supervised classification, the prediction performance of the assay revealed an area under the ROC curve of 0.98. In addition, categorizing the chemicals according to the LLNA assay, this gene signature could also predict sensitizing potency. The identified markers are involved in biological pathways with immunological relevant functions, which can shed light on the process of human sensitization. Conclusions A gene signature predicting sensitization, using a human cell line in vitro, has been identified. This simple and robust cell-based assay has the potential to completely replace or drastically reduce the utilization of test systems based on experimental animals. Being based on human biology, the assay is proposed to be more accurate for predicting sensitization in humans, than the traditional animal-based tests.

  6. Methods to measure peripheral and central sensitization using quantitative sensory testing: A focus on individuals with low back pain.

    Science.gov (United States)

    Starkweather, Angela R; Heineman, Amy; Storey, Shannon; Rubia, Gil; Lyon, Debra E; Greenspan, Joel; Dorsey, Susan G

    2016-02-01

    Quantitative sensory testing can be used to assess peripheral and central sensitization; important factors that contribute to the individual's experience of pain and disability. Many studies use quantitative sensory testing in patients with low back pain to detect alterations in pain sensitivity, however, because investigators employ different protocols, interpretation of findings across studies can become problematic. The purpose of this article is to propose a standardized method of testing peripheral and central pain sensitization in patients with low back pain. Video clips are provided to demonstrate correct procedures for measuring the response to experimental pain using mechanical, thermal and pressure modalities. As nurse researchers and clinicians increase utilization of quantitative sensory testing to examine pain phenotypes, it is anticipated that more personalized methods for monitoring the trajectory of low back pain and response to treatment will improve outcomes for this patient population. Copyright © 2015 Elsevier Inc. All rights reserved.

  7. Testing for Gluten-Related Disorders in Clinical Practice: The Role of Serology in Managing the Spectrum of Gluten Sensitivity

    Directory of Open Access Journals (Sweden)

    David Armstrong

    2011-01-01

    Full Text Available Immunoglobulin A tissue transglutaminase is the single most efficient serological test for the diagnosis of celiac disease. It is well known that immunoglobulin A tissue transglutaminase levels correlate with the degree of intestinal damage, and that values can fluctuate in patients over time. Serological testing can be used to identify symptomatic individuals that need a confirmatory biopsy, to screen at-risk populations or to monitor diet compliance in patients previously diagnosed with celiac disease. Thus, interpretation of serological testing requires consideration of the full clinical scenario. Antigliadin tests are no longer recommended for the diagnosis of classical celiac disease. However, our understanding of the pathogenesis and spectrum of gluten sensitivity has improved, and gluten-sensitive irritable bowel syndrome patients are increasingly being recognized. Studies are needed to determine the clinical utility of antigliadin serology in the diagnosis of gluten sensitivity.

  8. Willingness to pay and size of health benefit: an integrated model to test for 'sensitivity to scale'.

    Science.gov (United States)

    Yeung, Raymond Y T; Smith, Richard D; McGhee, Sarah M

    2003-09-01

    A key theoretical prediction concerning willingness to pay is that it is positively correlated with benefit size and is assessed by testing the 'sensitivity to scale (scope)'. 'External' (between-sample) sensitivity tests are usually regarded as less powerful than 'internal' (within-subject) tests. However, the latter may suffer from 'anchoring' effects. This paper studies the statistical power of these tests by questioning the distributional assumption of empirical data. We present an integrated model to capture both internal and external variations, while controlling for sample heterogeneity, applied to data from a survey estimating the value of reducing symptom-days. Results indicate that once data is properly transformed, WTP becomes 'scale sensitive' and consistent with diminishing marginal utility theory.

  9. Process Sensitivity, Performance, and Direct Verification Testing of Adhesive Locking Features

    Science.gov (United States)

    Golden, Johnny L.; Leatherwood, Michael D.; Montoya, Michael D.; Kato, Ken A.; Akers, Ed

    2012-01-01

    Phase I: The use of adhesive locking features or liquid locking compounds (LLCs) (e.g., Loctite) as a means of providing a secondary locking feature has been used on NASA programs since the Apollo program. In many cases Loctite was used as a last resort when (a) self-locking fasteners were no longer functioning per their respective drawing specification, (b) access was limited for removal & replacement, or (c) replacement could not be accomplished without severe impact to schedule. Long-term use of Loctite became inevitable in cases where removal and replacement of worn hardware was not cost effective and Loctite was assumed to be fully cured and working. The NASA Engineering & Safety Center (NESC) and United Space Alliance (USA) recognized the need for more extensive testing of Loctite grades to better understand their capabilities and limitations as a secondary locking feature. These tests, identified as Phase I, were designed to identify processing sensitivities, to determine proper cure time, the correct primer to use on aerospace nutplate, insert and bolt materials such as A286 and MP35N, and the minimum amount of Loctite that is required to achieve optimum breakaway torque values. The .1900-32 was the fastener size tested, due to wide usage in the aerospace industry. Three different grades of Loctite were tested. Results indicate that, with proper controls, adhesive locking features can be successfully used in the repair of locking features and should be considered for design. Phase II: Threaded fastening systems used in aerospace programs typically have a requirement for a redundant locking feature. The primary locking method is the fastener preload and the traditional redundant locking feature is a self-locking mechanical device that may include deformed threads, non-metallic inserts, split beam features, or other methods that impede movement between threaded members. The self-locking resistance of traditional locking features can be directly verified

  10. Point-Of-Care p24 Infant Testing for HIV May Increase Patient Identification despite Low Sensitivity.

    Science.gov (United States)

    Meggi, Bindiya; Bollinger, Timothy; Mabunda, Nédio; Vubil, Adolfo; Tobaiwa, Ocean; Quevedo, Jorge I; Loquiha, Osvaldo; Vojnov, Lara; Peter, Trevor F; Jani, Ilesh V

    2017-01-01

    The long delay in returning test results during early infant diagnosis of HIV (EID) often causes loss-to-follow-up prior to antiretroviral treatment (ART) initiation in resource-limited settings. A point-of-care (POC) test may help overcome these challenges. We evaluated the performance of the LYNX p24 Antigen POC test in Mozambique. 879 HIV-exposed infants under 18 months of age were enrolled consecutively at three primary healthcare clinics (PHC). Lancet heel-drawn blood was tested on-site by nurses using a prototype POC test for HIV Gag p24 antigen detection. Results of POC testing were compared to laboratory-based nucleic acid testing on dried blood spots. A comparison of the effect of sensitivity and timely test results return on successful diagnosis by POC and laboratory-based platforms was also calculated. The sensitivity and specificity of the LYNX p24 Ag test were 71.9%; (95% confidence interval [CI]: 58.5-83.0%) and 99.6% (95% CI: 98.9-99.9%), respectively. The predictive value of positive and negative tests were 93.2% (95% CI: 81.3-98.6%) and 97.9% (95% CI: 96.8-98.8%), respectively. Overall agreement was high (Cohen Kappa = 0.80; 95% CI: 0.71-0.89). Despite its lower sensitivity, the POC test had the potential to provide test results to up to 81% more patients compared to the laboratory-based test. This prototype POC p24 assay was feasible for use in PHCs but demonstrated low sensitivity for HIV detection. POC EID technologies that perform below standard recommendations may still be valuable diagnostic tools in settings with inefficient EID networks.

  11. Point-Of-Care p24 Infant Testing for HIV May Increase Patient Identification despite Low Sensitivity

    Science.gov (United States)

    Bollinger, Timothy; Mabunda, Nédio; Vubil, Adolfo; Tobaiwa, Ocean; Quevedo, Jorge I.; Loquiha, Osvaldo; Vojnov, Lara; Peter, Trevor F.; Jani, Ilesh V.

    2017-01-01

    The long delay in returning test results during early infant diagnosis of HIV (EID) often causes loss-to-follow-up prior to antiretroviral treatment (ART) initiation in resource-limited settings. A point-of-care (POC) test may help overcome these challenges. We evaluated the performance of the LYNX p24 Antigen POC test in Mozambique. 879 HIV-exposed infants under 18 months of age were enrolled consecutively at three primary healthcare clinics (PHC). Lancet heel-drawn blood was tested on-site by nurses using a prototype POC test for HIV Gag p24 antigen detection. Results of POC testing were compared to laboratory-based nucleic acid testing on dried blood spots. A comparison of the effect of sensitivity and timely test results return on successful diagnosis by POC and laboratory-based platforms was also calculated. The sensitivity and specificity of the LYNX p24 Ag test were 71.9%; (95% confidence interval [CI]: 58.5–83.0%) and 99.6% (95% CI: 98.9–99.9%), respectively. The predictive value of positive and negative tests were 93.2% (95% CI: 81.3–98.6%) and 97.9% (95% CI: 96.8–98.8%), respectively. Overall agreement was high (Cohen Kappa = 0.80; 95% CI: 0.71–0.89). Despite its lower sensitivity, the POC test had the potential to provide test results to up to 81% more patients compared to the laboratory-based test. This prototype POC p24 assay was feasible for use in PHCs but demonstrated low sensitivity for HIV detection. POC EID technologies that perform below standard recommendations may still be valuable diagnostic tools in settings with inefficient EID networks. PMID:28060886

  12. A highly sensitive and simply operated protease sensor toward point-of-care testing.

    Science.gov (United States)

    Park, Seonhwa; Shin, Yu Mi; Seo, Jeongwook; Song, Ji-Joon; Yang, Haesik

    2016-04-21

    Protease sensors for point-of-care testing (POCT) require simple operation, a detection period of less than 20 minutes, and a detection limit of less than 1 ng mL(-1). However, it is difficult to meet these requirements with protease sensors that are based on proteolytic cleavage. This paper reports a highly reproducible protease sensor that allows the sensitive and simple electrochemical detection of the botulinum neurotoxin type E light chain (BoNT/E-LC), which is obtained using (i) low nonspecific adsorption, (ii) high signal-to-background ratio, and (iii) one-step solution treatment. The BoNT/E-LC detection is based on two-step proteolytic cleavage using BoNT/E-LC (endopeptidase) and l-leucine-aminopeptidase (LAP, exopeptidase). Indium-tin oxide (ITO) electrodes are modified partially with reduced graphene oxide (rGO) to increase their electrocatalytic activities. Avidin is then adsorbed on the electrodes to minimize the nonspecific adsorption of proteases. Low nonspecific adsorption allows a highly reproducible sensor response. Electrochemical-chemical (EC) redox cycling involving p-aminophenol (AP) and dithiothreitol (DTT) is performed to obtain a high signal-to-background ratio. After adding a C-terminally AP-labeled oligopeptide, DTT, and LAP simultaneously to a sample solution, no further treatment of the solution is necessary during detection. The detection limits of BoNT/E-LC in phosphate-buffered saline are 0.1 ng mL(-1) for an incubation period of 15 min and 5 fg mL(-1) for an incubation period of 4 h. The detection limit in commercial bottled water is 1 ng mL(-1) for an incubation period of 15 min. The developed sensor is selective to BoNT/E-LC among the four types of BoNTs tested. These results indicate that the protease sensor meets the requirements for POCT.

  13. Sensitive immunochemical approaches for quantitative (FPIA) and qualitative (lateral flow tests) determination of gentamicin in milk.

    Science.gov (United States)

    Beloglazova, N V; Shmelin, P S; Eremin, S A

    2016-01-01

    Three kinds of immunoassays for the determination of gentamicin in milk samples were developed and validated. First, a fast and easily-performed fluorescence polarization immunoassay was used for characterization of the employed polyclonal antibody. The calculated Kaff were (1.9±0.4)×10(9)М(-1) and (6.0±0.2)×10(6)М(-1) for the high- and low-affinity fractions respectively. The assay was characterized with a good sensitivity, the limit of detection being 5μgkg(-1). Two different kinds of detection labels, i.e. colloidal gold (CG) and quantum dots (QDs), were evaluated for use in lateral-flow format with respect to rapid visual on-site testing. The cut-off levels for both qualitative formats were selected based on the maximum level for gentamicin in milk established by the European Commission, 100μgkg(-1), resulting in a 10μgkg(-1) cut-off considering sample dilution. The intra-laboratory validation was performed with sterilized milk samples artificially spiked with gentamicin at concentrations less than, equal to, and greater than the cut-off level. It was shown that milk products could be analyzed without any sample preparation, except for dilution with the buffer solution. The rates of false-positive and false-negative results were below 5% for both labels. The different developed immunoassays were tested towards gentamicin determination in artificially-spiked and naturally contaminated milk samples. Copyright © 2015 Elsevier B.V. All rights reserved.

  14. Sensitivity test of parameterizations of subgrid-scale orographic form drag in the NCAR CESM1

    Science.gov (United States)

    Liang, Yishuang; Wang, Lanning; Zhang, Guang Jun; Wu, Qizhong

    2016-08-01

    Turbulent drag caused by subgrid orographic form drag has significant effects on the atmosphere. It is represented through parameterization in large-scale numerical prediction models. An indirect parameterization scheme, the Turbulent Mountain Stress scheme (TMS), is currently used in the National Center for Atmospheric Research Community Earth System Model v1.0.4. In this study we test a direct scheme referred to as BBW04 (Beljaars et al. in Q J R Meteorol Soc 130:1327-1347, 2004. doi: 10.1256/qj.03.73), which has been used in several short-term weather forecast models and earth system models. Results indicate that both the indirect and direct schemes increase surface wind stress and improve the model's performance in simulating low-level wind speed over complex orography compared to the simulation without subgrid orographic effect. It is shown that the TMS scheme produces a more intense wind speed adjustment, leading to lower wind speed near the surface. The low-level wind speed by the BBW04 scheme agrees better with the ERA-Interim reanalysis and is more sensitive to complex orography as a direct method. Further, the TMS scheme increases the 2-m temperature and planetary boundary layer height over large areas of tropical and subtropical Northern Hemisphere land.

  15. Test Sensitivity in the Computer-Aided Detection of Breast Cancer from Clinical Mammographic Screening: a Meta-analysis

    CERN Document Server

    Levman, Jacob

    2013-01-01

    Objectives: To assess evaluative methodologies for comparative measurements of test sensitivity in clinical mammographic screening trials of computer-aided detection (CAD) technologies. Materials and Methods: This meta-analysis was performed by analytically reviewing the relevant literature on the clinical application of computer-aided detection (CAD) technologies as part of a breast cancer screening program based on x-ray mammography. Each clinical study's method for measuring the CAD system's improvement in test sensitivity is examined in this meta-analysis. The impact of the chosen sensitivity measurement on the study's conclusions are analyzed. Results: This meta-analysis demonstrates that some studies have inappropriately compared sensitivity measurements between control groups and CAD enabled groups. The inappropriate comparison of control groups and CAD enabled groups can lead to an underestimation of the benefits of the clinical application of computer-aided detection technologies. Conclusions: The po...

  16. Theoretical analyses and numerical simulations of the torsional mode for two acoustic viscometers with preliminary experimental tests.

    Science.gov (United States)

    Ai, Yuhui; Lange, Rebecca A

    2008-03-01

    A rigorous analysis of the torsional modes in both a cylindrical wave guide and the associated static viscous fluid field has been conducted from the solid and the fluid wave equations and the coupled boundary conditions. As a result, two acoustic viscometer models, along with four independent equations connecting the density and the viscosity of the fluid with the attenuation and the phase velocity of the torsional wave in the wave guide, have been developed. The analysis shows that the product of the viscosity and the density of the fluid can be measured from the end reflection coefficient of the torsional wave in the wave guide and that both the viscosity and the density can be determined simultaneously from either the phase velocity or the attenuation of the torsional wave in a single cylindrical wave guide. For the simultaneous measurements of the viscosity and the density, the independent equations have to be solved numerically, for example, using Matlab (The MathWorks, Natick, MA), given either the attenuation or the phase velocity in the wave guide that is surrounded by the fluid. To demonstrate the technical feasibility, numerical simulations have been conducted to discern viscosity, phase velocity, and density, all versus attenuation, at different frequencies, and with variable dimension of a molybdenum rod, so that both the advantages and the disadvantages of the simultaneous measurements can be explored. In the end, to test the two models, preliminary experiments on two viscous standards were conducted at 23 degrees C, and good agreements have been achieved between the viscosities measured from both models and for both standards.

  17. Sensitivity of surveillance testing for multidrug-resistant Gram-negative bacteria in the intensive care unit.

    Science.gov (United States)

    Ridgway, Jessica P; Peterson, Lance R; Thomson, Richard B; Miller, Becky A; Wright, Marc-Oliver; Schora, Donna M; Robicsek, Ari

    2014-11-01

    We tested intensive care unit patients for colonization with multidrug-resistant Gram-negative bacilli (MDR GNB) and compared the results with those of concurrent clinical cultures. The sensitivity of the surveillance test for detecting MDR GNB was 58.8% (95% confidence interval, 48.6 to 68.5%). Among 133 patients with positive surveillance tests, 61% had no prior clinical culture with MDR GNB.

  18. Aerobic exercise in adolescents with obesity: preliminary evaluation of a modular training program and the modified shuttle test

    Directory of Open Access Journals (Sweden)

    van der Baan-Slootweg Olga H

    2007-04-01

    Full Text Available Abstract Background Increasing activity levels in adolescents with obesity requires the development of exercise programs that are both attractive to adolescents and easily reproducible. The aim of this study was to develop a modular aerobic training program for adolescents with severe obesity, with a focus on variety, individual targets and acquiring physical skills. We report here the effects on aerobic fitness from a pilot study. Furthermore, we examined the feasibility of the modified shuttle test (MST as an outcome parameter for aerobic fitness in adolescents with severe obesity. Methods Fifteen adolescents from an inpatient body weight management program participated in the aerobic training study (age 14.7 ± 2.1 yrs, body mass index 37.4 ± 3.5. The subjects trained three days per week for 12 weeks, with each session lasting 30–60 minutes. The modular training program consisted of indoor, outdoor and swimming activities. Feasibility of the MST was studied by assessing construct validity, test-retest reliability and sensitivity to change. Results Comparing pretraining and end of training period showed large clinically relevant and significant improvements for all aerobic indices: e.g. VO2 peak 17.5%, effect size (ES 2.4; Wmax 8%, ES 0.8. In addition, a significant improvement was found for the efficiency of the cardiovascular system as assessed by the oxygen pulse (15.8%, ES 1.6. Construct validity, test-retest reliability and sensitivity to change of the MST were very good. MST was significantly correlated with VO2 peak (r = 0.79 and Wmax (r = 0.84 but not with anthropometric measures. The MST walking distance improved significantly by 32.5%, ES 2.5. The attendance rate at the exercise sessions was excellent. Conclusion This modular, varied aerobic training program has clinically relevant effects on aerobic performance in adolescents with severe obesity. The added value of our aerobic training program for body weight management programs

  19. Fast Responding Pressure-Sensitive Paint for Large-Scale Wind Tunnel Testing Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed work focuses on implementing fast-response pressure-sensitive paint for measurements of unsteady pressure in rotorcraft applications. Significant...

  20. Plot-scale testing and sensitivity analysis of Be7 based soil erosion conversion models

    Science.gov (United States)

    Taylor, Alex; Abdelli, Wahid; Barri, Bashar Al; Iurian, Andra; Gaspar, Leticia; Mabit, Lionel; Millward, Geoff; Ryken, Nick; Blake, Will

    2016-04-01

    an estimated amount of sediment delivered from the plot for comparison with the true mass captured. Sensitivity analysis was undertaken to evaluate the influence of (1) variability in Be-7 depth distribution, (2) selection of particle size correction factors and (3) potential loss of Be-7 in overland flow after SOF initiation on model output. Order of magnitude differences in sediment export estimates across the tested scenarios underpins the critical need for adequately addressing sources of uncertainty in experimental design and sampling programmes. Recommendations are made to improve methodological accuracy and confidence in model outputs.

  1. Sensitivity of wetland methane emissions to model assumptions: application and model testing against site observations

    Directory of Open Access Journals (Sweden)

    L. Meng

    2011-06-01

    Full Text Available Methane emissions from natural wetlands and rice paddies constitute a large proportion of atmospheric methane, but the magnitude and year-to-year variation of these methane sources is still unpredictable. Here we describe and evaluate the integration of a methane biogeochemical model (CLM4Me; Riley et al., 2011 into the Community Land Model 4.0 (CLM4CN in order to better explain spatial and temporal variations in methane emissions. We test new functions for soil pH and redox potential that impact microbial methane production in soils. We also constrain aerenchyma in plants in always-inundated areas in order to better represent wetland vegetation. Satellite inundated fraction is explicitly prescribed in the model because there are large differences between simulated fractional inundation and satellite observations. A rice paddy module is also incorporated into the model, where the fraction of land used for rice production is explicitly prescribed. The model is evaluated at the site level with vegetation cover and water table prescribed from measurements. Explicit site level evaluations of simulated methane emissions are quite different than evaluating the grid cell averaged emissions against available measurements. Using a baseline set of parameter values, our model-estimated average global wetland emissions for the period 1993–2004 were 256 Tg CH4 yr−1, and rice paddy emissions in the year 2000 were 42 Tg CH4 yr−1. Tropical wetlands contributed 201 Tg CH4 yr−1, or 78 % of the global wetland flux. Northern latitude (>50 N systems contributed 12 Tg CH4 yr−1. We expect this latter number may be an underestimate due to the low high-latitude inundated area captured by satellites and unrealistically low high-latitude productivity and soil carbon predicted by CLM4. Sensitivity analysis showed a large range (150–346 Tg CH4 yr−1 in

  2. Proposal of abolition of the skin sensitivity test before equine rabies immune globulin application

    Directory of Open Access Journals (Sweden)

    CUPO Palmira

    2001-01-01

    Full Text Available An epizootic outbreak of rabies occurred in 1995 in Ribeirão Preto, SP, with 58 cases of animal rabies (54 dogs, 3 cats and 1 bat confirmed by the Pasteur Institute of São Paulo, and one human death. The need to provide care to a large number of people for the application of equine rabies immune globulin (ERIG prevented the execution of the skin sensitivity test (SST and often also the execution of desensitization, procedures routinely used up to that time at the Emergency Unit of the University Hospital of the Faculty of Medicine of Ribeirão Preto, University of São Paulo (EU-UHFMRP-USP, a reference hospital for the application of heterologous sera. In view of our positive experience of several years with the abolition of SST and of the use of premedication before the application of antivenom sera, we used a similar schedule for ERIG application. Of the 1489 victims of animal bites, 1054 (71% received ERIG; no patient was submitted to SST and all received intravenously anti-histamines (anti-H1 + anti-H2 and corticosteroids before the procedure. The patients were kept under observation for 60 to 180 minutes and no adverse reaction was observed. On the basis of these results, since December 1995 ERIG application has been decentralized in Ribeirão Preto and has become the responsibility of the Emergency Unit of the University Hospital and the Central Basic Health Unit, where the same routine is used. Since then, 4216 patients have received ERIG (1818 at the Basic Health Unit and 2398 at the EU-UHFMRP, with no problems. The ideal would be the routine use of human rabies immune globulin (HRIG in public health programs, but this is problematic, because of their high cost. However, while this does not occur, the use of SST is no longer justified at the time of application of ERIG, in view of the clinical evidence of low predictive value and low sensitivity of SST involving the application of heterologous sera. It is very important to point out

  3. Sensitivity Comparison of the Skin Prick Test and Serum and Fecal Radio Allergosorbent Test (RAST in Diagnosis of Food Allergy in Children

    Directory of Open Access Journals (Sweden)

    Hamid Reza Kianifar

    2016-05-01

    Full Text Available Background: Diagnosis of food allergy is difficult in children. Food allergies are diagnosed using several methods that include medical histories, clinical examinations, skin prick and serum-specific immunoglobulin E (IgE tests, radio-allergosorbent test (RAST, food challenge, and supervised elimination diets. In this study we evaluated allergies to cow's milk, egg, peanut, and fish in children with suspected food allergies with skin prick tests and serum and feces RAST. Methods: Forty-one children with clinical symptoms of food allergies were enrolled in the study. Skin prick tests and serum and fecal RAST were performed and compared with challenge tests. Results: The most common sites of food allergy symptoms were gastrointestinal (82.9% and skin (48.8%. 100% of the patients responded to the challenge tests with cow’s milk, egg, peanut, and fish. 65% of the patients tested positive with the skin prick test, 12.1% tested positive with serum RAST, and 29.2% tested positive with fecal RAST. Conclusions: The skin prick test was more sensitive than serum or fecal RAST, and fecal RAST was more than twice as sensitive as serum RAST.

  4. Tracer SWIW tests in propped and un-propped fractures: parameter sensitivity issues, revisited

    Science.gov (United States)

    Ghergut, Julia; Behrens, Horst; Sauter, Martin

    2017-04-01

    Single-well injection-withdrawal (SWIW) or 'push-then-pull' tracer methods appear attractive for a number of reasons: less uncertainty on design and dimensioning, and lower tracer quantities required than for inter-well tests; stronger tracer signals, enabling easier and cheaper metering, and shorter metering duration required, reaching higher tracer mass recovery than in inter-well tests; last not least: no need for a second well. However, SWIW tracer signal inversion faces a major issue: the 'push-then-pull' design weakens the correlation between tracer residence times and georeservoir transport parameters, inducing insensitivity or ambiguity of tracer signal inversion w. r. to some of those georeservoir parameters that are supposed to be the target of tracer tests par excellence: pore velocity, transport-effective porosity, fracture or fissure aperture and spacing or density (where applicable), fluid/solid or fluid/fluid phase interface density. Hydraulic methods cannot measure the transport-effective values of such parameters, because pressure signals correlate neither with fluid motion, nor with material fluxes through (fluid-rock, or fluid-fluid) phase interfaces. The notorious ambiguity impeding parameter inversion from SWIW test signals has nourished several 'modeling attitudes': (i) regard dispersion as the key process encompassing whatever superposition of underlying transport phenomena, and seek a statistical description of flow-path collectives enabling to characterize dispersion independently of any other transport parameter, as proposed by Gouze et al. (2008), with Hansen et al. (2016) offering a comprehensive analysis of the various ways dispersion model assumptions interfere with parameter inversion from SWIW tests; (ii) regard diffusion as the key process, and seek for a large-time, asymptotically advection-independent regime in the measured tracer signals (Haggerty et al. 2001), enabling a dispersion-independent characterization of multiple

  5. Sensitivity, specificity and positive predictive value of patch testing : the more you test, the more you get?

    NARCIS (Netherlands)

    Diepgen, TL; Coenraads, PJ

    2000-01-01

    Pathophysiological variability affects the results of patch testing. In addition, even a minimal degree of test-imprecision due to this variability has a number of important statistical consequences for the analysis and interpretation of any patch test data set. One such statistical phenomenon that

  6. Testing the Nanoparticle-Allostatic Cross Adaptation-Sensitization Model for Homeopathic Remedy Effects

    OpenAIRE

    Bell, Iris R.; Koithan, Mary; Brooks, Audrey J.

    2013-01-01

    Key concepts of the Nanoparticle-Allostatic Cross-Adaptation-Sensitization (NPCAS) Model for the action of homeopathic remedies in living systems include source nanoparticles as low level environmental stressors, heterotypic hormesis, cross-adaptation, allostasis (stress response network), time-dependent sensitization with endogenous amplification and bidirectional change, and self-organizing complex adaptive systems.

  7. Evaluation of human skin tests for potential dermal irritant and contact sensitizing products: a position paper

    NARCIS (Netherlands)

    Loveren H van; Jong WH de; Garssen J; LPI

    1998-01-01

    Prediction of human cutaneous irritation and sensitization in view of hazard identification has primarily relied on the use of laboratory animals. Such studies in laboratory animals have been very instrumental in the detection of potential contact sensitizing agents. There are however many uncertain

  8. Adolescent behavioral and neural reward sensitivity : a test of the differential susceptibility theory

    NARCIS (Netherlands)

    Richards, J. S.; Vasquez, A. Arias; von Rhein, D.; van der Meer, D.; Franke, B.; Hoekstra, P. J.; Heslenfeld, D. J.; Oosterlaan, J.; Faraone, S. V.; Buitelaar, J. K.; Hartman, C. A.

    2016-01-01

    Little is known about the causes of individual differences in reward sensitivity. We investigated gene-environment interactions (GxE) on behavioral and neural measures of reward sensitivity, in light of the differential susceptibility theory. This theory states that individuals carrying plasticity g

  9. Underreporting of Dengue-4 in Brazil due to low sensitivity of the NS1 Ag test in routine control programs.

    Directory of Open Access Journals (Sweden)

    Vanessa Ramos Faria Sea

    Full Text Available We have identified fifty-eight samples that were positive for Dengue-4 among 119 samples with negative diagnoses for dengue via the Platelia™ dengue NS1 Ag in Aracaju, State of Sergipe, Brazil. We determined that the low sensitivity of the NS1 Ag test could be related to secondary dengue infections in the studied population. Therefore, we concluded that the sensitivity and specificity of the Platelia™ dengue NS1 Ag test as a screening method for monitoring circulating dengue serotypes must be reevaluated. In addition, regional endo-epidemic profiles should also be considered due to the prevalence of secondary responses.

  10. Estimation of the relative sensitivity of the comparative tuberculin skin test in tuberculous cattle herds subjected to depopulation.

    Directory of Open Access Journals (Sweden)

    Katerina Karolemeas

    Full Text Available Bovine tuberculosis (bTB is one of the most serious economic animal health problems affecting the cattle industry in Great Britain (GB, with incidence in cattle herds increasing since the mid-1980s. The single intradermal comparative cervical tuberculin (SICCT test is the primary screening test in the bTB surveillance and control programme in GB and Ireland. The sensitivity (ability to detect infected cattle of this test is central to the efficacy of the current testing regime, but most previous studies that have estimated test sensitivity (relative to the number of slaughtered cattle with visible lesions [VL] and/or positive culture results lacked post-mortem data for SICCT test-negative cattle. The slaughter of entire herds ("whole herd slaughters" or "depopulations" that are infected by bTB are occasionally conducted in GB as a last-resort control measure to resolve intractable bTB herd breakdowns. These provide additional post-mortem data for SICCT test-negative cattle, allowing a rare opportunity to calculate the animal-level sensitivity of the test relative to the total number of SICCT test-positive and negative VL animals identified post-mortem (rSe. In this study, data were analysed from 16 whole herd slaughters (748 SICCT test-positive and 1031 SICCT test-negative cattle conducted in GB between 1988 and 2010, using a bayesian hierarchical model. The overall rSe estimate of the SICCT test at the severe interpretation was 85% (95% credible interval [CI]: 78-91%, and at standard interpretation was 81% (95% CI: 70-89%. These estimates are more robust than those previously reported in GB due to inclusion of post-mortem data from SICCT test-negative cattle.

  11. Preliminary data for northern Great Plains test well 1, quarter NE quarter Sec. 11, T.55N., R.77W., Sheridan County, Wyoming

    Science.gov (United States)

    Lobmeyer, D.H.; Anna, L.O.; Busby, J.F.

    1982-01-01

    This report documents the preliminary data obtained from Northern Great Plains test well 1 and describes the preliminary results and future testing plans. The intended audience includes hydrologists, local water users, drilling contractors, and water managers. The test well was drilled as part of the study to determine the water resource potential of the regional aquifer system in the Northern Great Plains, an area of about 250,000 sq mi. The well is 4,485 ft deep; nine cores were drilled totaling 182 ft; 157.42 ft of core were recovered. Sidewall cores were obtained from 24 horizons. Gamma and density scans of the cores were made, and selected parts were tested for density, porosity, and vertical and horizontal permeability. Eight zones were perforated and tested using conventional drill-stem tests and swabbing. Water samples were obtained from seven zones. No major potential sources of groundwater were penetrated by the test well. Estimated yields from selected zones range from about 240 gal/min with 400 ft of drawdown to about 5 gal/min flow at the surface. Dissolved-solids concentrations ranged from about 1,800 to 3,000 mg/l. (USGS)

  12. IASI's sensitivity to near-surface carbon monoxide (CO): Theoretical analyses and retrievals on test cases

    Science.gov (United States)

    Bauduin, Sophie; Clarisse, Lieven; Theunissen, Michael; George, Maya; Hurtmans, Daniel; Clerbaux, Cathy; Coheur, Pierre-François

    2017-03-01

    Separating concentrations of carbon monoxide (CO) in the boundary layer from the rest of the atmosphere with nadir satellite measurements is of particular importance to differentiate emission from transport. Although thermal infrared (TIR) satellite sounders are considered to have limited sensitivity to the composition of the near-surface atmosphere, previous studies show that they can provide information on CO close to the ground in case of high thermal contrast. In this work we investigate the capability of IASI (Infrared Atmospheric Sounding Interferometer) to retrieve near-surface CO concentrations, and we quantitatively assess the influence of thermal contrast on such retrievals. We present a 3-part analysis, which relies on both theoretical forward simulations and retrievals on real data, performed for a large range of negative and positive thermal contrast situations. First, we derive theoretically the IASI detection threshold of CO enhancement in the boundary layer, and we assess its dependence on thermal contrast. Then, using the optimal estimation formalism, we quantify the role of thermal contrast on the error budget and information content of near-surface CO retrievals. We demonstrate that, contrary to what is usually accepted, large negative thermal contrast values (ground cooler than air) lead to a better decorrelation between CO concentrations in the low and the high troposphere than large positive thermal contrast (ground warmer than the air). In the last part of the paper we use Mexico City and Barrow as test cases to contrast our theoretical predictions with real retrievals, and to assess the accuracy of IASI surface CO retrievals through comparisons to ground-based in-situ measurements.

  13. Repeatability of contrast sensitivity testing in patients with age-related macular degeneration, glaucoma, and cataract

    Directory of Open Access Journals (Sweden)

    Selcuk Kara

    Full Text Available ABSTRACT Purpose: To analyze the intrasession and intersession repeatability of contrast sensitivity (CS measurements in patients with glaucoma, cataract, or age-related macular degeneration (AMD and healthy controls. Methods: CS measurements were performed using the OPTEC-Functional Vision Analyzer (FVA, which uses a standardized and closed (view-in system. Measurements for patients with glaucoma, cataract, or AMD and healthy controls were repeated within 30 minutes (intrasession and during two sessions (intersession, separated by one week to one month. Test-retest reliability and correlation were measured using the intraclass correlation coefficient (ICC and coefficient of repeatability (COR. Results: Ninety subjects (90 eyes with visual acuity of 0.17 logMAR or higher in the cataract group or 0.00 logMAR in the other groups were included. During the first session, the ICC values were 0.87, 0.90, 0.76, and 0.69, and COR values were 0.24, 0.20, 0.38, and 0.25 for the control, glaucoma, cataract, and AMD groups, respectively. The reliability scores significantly improved during the second session, except in the glaucoma group. There was an acceptable floor effect and no ceiling effect at higher frequencies in the glaucoma and AMD groups. Conclusion: In subjects with good visual acuity, the FVA system is useful for evaluating CS and demonstrates good repeatability, as shown by ICC and COR. Because there is no ceiling effect, this system is beneficial for evaluation of early changes in CS, particularly in patients with glaucoma or AMD.

  14. Preliminary Derivation of Test Item Clusters for Predicting Injuries, Poor Physical Performance, and Overall Attrition in Basic Combat Training

    Science.gov (United States)

    2006-12-01

    examination and patient self-report measures for cervical radiculopathy. Spine. Jan 1 2003;28(1):52-62. 36 11. Wainner RS, Fritz JM, Irrgang JJ...foot orthosis use and modified activity: a preliminary investigation. Phys Ther. Jan 2004;84(1):49-61. 18. Solomon DH, Avorn J, Warsi A, et al

  15. Sensitivity and specificity of various serologic tests for detection of Toxoplasma gondii infection in naturally infected sows

    DEFF Research Database (Denmark)

    Dubey, J.P.; Thulliez, P.; Weigel, R.M.;

    1995-01-01

    The sensitivity and specificity of various serologic tests for antibodies to Toxoplasma gondii were compared in 1,000 naturally exposed sows, using isolation of viable T gondii as the definitive test. Serum samples obtained from heart blood of 1,000 sows from Iowa were examined for T gondii......, 29.4 and 98.3% for IHAT, 45.9 and 96.9% for LAT, and 72.9 and 85.9% for ELISA. The dye test was run at 1:20 dilution on only 893 sera because of bacterial contamination and presence of anticomplement substances. Dye test antibodies were found in 17.8% of the sera, and sensitivity and specificity were...

  16. Sensitivity of microscale ecotoxicity tests and their suitability to measure toxicity of environmental samples

    NARCIS (Netherlands)

    Vaal MA; Folkerts AJ; ECO

    1998-01-01

    Aquatic microbiotests were selected and evaluated for their potential usefulness in measuring ecotoxicity in monitoring programs. Microbiotests are tests with aquatic invertebrates that demand a shorter exposure period and a smaller test volume than conventional aquatic ecotoxicity test methods. Mi

  17. Long-term repeatability of the skin prick test is high when supported by history or allergen-sensitivity tests

    DEFF Research Database (Denmark)

    Bodtger, U; Jacobsen, C R; Poulsen, Lars K.

    2003-01-01

    Long-term reproducibility of the skin-prick test (SPT) has been questioned. The aim of the study was to investigate the clinical relevance of SPT changes.......Long-term reproducibility of the skin-prick test (SPT) has been questioned. The aim of the study was to investigate the clinical relevance of SPT changes....

  18. A sensitive bacterial-growth-based test reveals how intestinal Bacteroides meet their porphyrin requirement

    OpenAIRE

    Halpern, David

    2015-01-01

    Background Bacteroides sp. are dominant constituents of the human and animal intestinal microbiota require porphyrins (i.e., protoporphyrin IX or iron-charged heme) for normal growth. The highly stimulatory effect of porphyrins on Bacteroides growth lead us to propose their use as a potential determinant of bacterial colonization. However, showing a role for porphryins would require sensitive detection methods that work in complex samples such as feces. Results We devised a highly sensitive s...

  19. Longevity Tests of High-Sensitivity BD-PND Bubble Dosimeters

    Energy Technology Data Exchange (ETDEWEB)

    Radev, R; Carlberg, E

    2002-07-09

    Medium- and very-high-sensitivity neutron bubble dosimeters (BD-PNDs) made by Bubble Technology Industries (BTI) were used to study the life span of such dosimeters in a standard setup with a {sup 252}Cf source. Although data on the longevity of bubble dosimeters with low and medium sensitivity exist, such data for dosimeters with high and very high sensitivity are not readily available. The manufacturer guarantees optimum dosimeter performance for 3 months after receipt. However, it is important to know the change in the dosimeters' characteristics with time, especially after the first 3 months. The long-term performance of four sets of very high sensitivity and one set of medium-sensitivity bubble dosimeters was examined for periods of up to 13 months. During that time, the detectors were exposed and reset more than 20 times. Although departures from initial detection sensitivity were observed in several cases, the detectors indicated a significantly longer life span than stated in the manufacturer's warranty. In addition, the change in the number of bubbles and in evaluated neutron dose as a function of the time from the end of exposure until the dosimeters were read was investigated.

  20. The sensitivity of acoustic cough recording relative to intraesophageal pressure recording and patient report during reflux testing.

    Science.gov (United States)

    Rosen, R; Amirault, J; Heinz, N; Litman, H; Khatwa, U

    2014-11-01

    One of the primary indications for reflux testing with multichannel intraluminal impedance with pH (pH-MII) is to correlate reflux events with symptoms such as cough. Adult and pediatric studies have shown, using cough as a model, that patient report of symptoms is inaccurate. Unfortunately, intraesophageal pressure recording (IEPR) to record coughs is more invasive which limits its utility in children. The primary aim of this study was to validate the use of acoustic cough recording (ACR) during pH-MII testing. We recruited children undergoing pH-MII testing for the evaluation of cough. We simultaneously placed IEPR and pH-MII catheters and an ACR device in each patient. Each 24 h ACR, pH-MII, and IEPR tracing was scored by blinded investigators. Sensitivities for each method of symptom recording were calculated. A total of 2698 coughs were detected; 1140 were patient reported PR, 2425 were IEPR detected, and 2400 were ACR detected. The sensitivity of PR relative to ACR was 45.9% and the sensitivity of IEPR relative to ACR was 93.6%. There was strong inter-rater reliability (κ = 0.78) for the identification of cough by ACR. Acoustic recording is a non-invasive, sensitive method of recording cough during pH-MII testing that is well suited for the pediatric population. © 2014 John Wiley & Sons Ltd.

  1. An integrated electrochemical device based on immunochromatographic test strip and enzyme labels for sensitive detection of disease-related biomarkers

    Energy Technology Data Exchange (ETDEWEB)

    Zou, Zhexiang; Wang, Jun; Wang, Hua; Li, Yao Q.; Lin, Yuehe

    2012-05-30

    A novel electrochemical biosensing device that integrates an immunochromatographic test strip and a screen-printed electrode (SPE) connected to a portable electrochemical analyzer was presented for rapid, sensitive, and quantitative detection of disease-related biomarker in human blood samples. The principle of the sensor is based on sandwich immunoreactions between a biomarker and a pair of its antibodies on the test strip, followed by highly sensitive square-wave voltammetry (SWV) detection. Horseradish peroxidase (HRP) was used as a signal reporter for electrochemical readout. Hepatitis B surface antigen (HBsAg) was employed as a model protein biomarker to demonstrate the analytical performance of the sensor in this study. Some critical parameters governing the performance of the sensor were investigated in detail. The sensor was further utilized to detect HBsAg in human plasma with an average recovery of 91.3%. In comparison, a colorimetric immunochromatographic test strip assay (ITSA) was also conducted. The result shows that the SWV detection in the electrochemical sensor is much more sensitive for the quantitative determination of HBsAg than the colorimetric detection, indicating that such a sensor is a promising platform for rapid and sensitive point-of-care testing/screening of disease-related biomarkers in a large population

  2. A simple and sensitive quality control method of the anaerobic atmosphere for identification and antimicrobial susceptibility testing of anaerobic bacteria

    DEFF Research Database (Denmark)

    Justesen, Tage; Justesen, Ulrik Stenz

    2013-01-01

    The maintenance of a strict anaerobic atmosphere is essential for the culture of strict anaerobic bacteria. We describe a simple and sensitive quality control method of the anaerobic atmosphere, based on the measurement of the zone diameter around a 5-μg metronidazole disk when testing an aerotol...

  3. A short-term in vitro test for tumour sensitivity to adriamycin based on flow cytometric DNA analysis

    DEFF Research Database (Denmark)

    Engelholm, S A; Spang-Thomsen, M; Vindeløv, L L

    1983-01-01

    A new method to test the sensitivity of tumour cells to chemotherapy is presented. Tumour cells were incubated in vitro on agar, and drug-induced cell cycle perturbation was monitored by flow cytometric DNA analysis. In the present study the method was applied to monitor the effect of adriamycin...

  4. Repetitive testing of TBTO, Sea-Nine 211 and farnesol using Balanus Amphitrite (Darwin) cypris larvae: variability in larval sensitivity

    NARCIS (Netherlands)

    Willemsen, P.R.; Overbeke, J.C.; Suurmond, A.

    1998-01-01

    Settlement inhibition assays with mass cultured cypris larvae of the barnacle Balanus amphitrite are widely used in (anti)fouling research. In this study, TBTO, Sea-Nine 211 and farnesol were tested repeatedly using multiple batches of larvae to study variability in larval sensitivity. There were si

  5. Preliminary experimental results using the thermal-hydraulic integral test facility (VISTA) for the pilot plant of the system integrated modular advanced reactor, SMART-P

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Ki Yong; Pak, Hyun Sik; Cho, Seok; Pak, Choon Kyung; Lee, Sung Jae; Song, Chul Hwa; Chung, Moon Ki [KAERI, Taejon (Korea, Republic of)

    2003-07-01

    Preliminary experimental tests were carried out using the thermal-hydraulic integral test facility, VISTA (Experimental Verification by Integral Simulation of Transients and Accidents), which has been constructed to simulate the SMART-P. The VISTA facility is an integral test facility including the primary and secondary systems as well as safety-related Passive Residual heat removal (PRHR) systems. Its scaled ratio with respect to the SMART-P is 1/1 in height and 1/96 in volume and heater power. So far, several steady states and transient tests have been carried out to verify the overall thermal hydraulic primary and secondary characteristics in a range of 10% to 100% power operation. As results of preliminary results, the steady state conditions were found to coincide with the expected design values of the SMART-P. But the major thermal hydraulic parameters are greatly affected by the initial water level and the nitrogen pressure in the reactor upper annular cavity. In the PRHR transient tests, the steam inlet temperature of the PRHR system is found to drop suddenly from a superheated condition to a saturated condition at the end period of PRHR operation.

  6. Increasing the Depth of Current Understanding: Sensitivity Testing of Deep-Sea Larval Dispersal Models for Ecologists.

    Science.gov (United States)

    Ross, Rebecca E; Nimmo-Smith, W Alex M; Howell, Kerry L

    2016-01-01

    Larval dispersal is an important ecological process of great interest to conservation and the establishment of marine protected areas. Increasing numbers of studies are turning to biophysical models to simulate dispersal patterns, including in the deep-sea, but for many ecologists unassisted by a physical oceanographer, a model can present as a black box. Sensitivity testing offers a means to test the models' abilities and limitations and is a starting point for all modelling efforts. The aim of this study is to illustrate a sensitivity testing process for the unassisted ecologist, through a deep-sea case study example, and demonstrate how sensitivity testing can be used to determine optimal model settings, assess model adequacy, and inform ecological interpretation of model outputs. Five input parameters are tested (timestep of particle simulator (TS), horizontal (HS) and vertical separation (VS) of release points, release frequency (RF), and temporal range (TR) of simulations) using a commonly employed pairing of models. The procedures used are relevant to all marine larval dispersal models. It is shown how the results of these tests can inform the future set up and interpretation of ecological studies in this area. For example, an optimal arrangement of release locations spanning a release area could be deduced; the increased depth range spanned in deep-sea studies may necessitate the stratification of dispersal simulations with different numbers of release locations at different depths; no fewer than 52 releases per year should be used unless biologically informed; three years of simulations chosen based on climatic extremes may provide results with 90% similarity to five years of simulation; and this model setup is not appropriate for simulating rare dispersal events. A step-by-step process, summarising advice on the sensitivity testing procedure, is provided to inform all future unassisted ecologists looking to run a larval dispersal simulation.

  7. Increasing the Depth of Current Understanding: Sensitivity Testing of Deep-Sea Larval Dispersal Models for Ecologists

    Science.gov (United States)

    Nimmo-Smith, W. Alex M.; Howell, Kerry L.

    2016-01-01

    Larval dispersal is an important ecological process of great interest to conservation and the establishment of marine protected areas. Increasing numbers of studies are turning to biophysical models to simulate dispersal patterns, including in the deep-sea, but for many ecologists unassisted by a physical oceanographer, a model can present as a black box. Sensitivity testing offers a means to test the models’ abilities and limitations and is a starting point for all modelling efforts. The aim of this study is to illustrate a sensitivity testing process for the unassisted ecologist, through a deep-sea case study example, and demonstrate how sensitivity testing can be used to determine optimal model settings, assess model adequacy, and inform ecological interpretation of model outputs. Five input parameters are tested (timestep of particle simulator (TS), horizontal (HS) and vertical separation (VS) of release points, release frequency (RF), and temporal range (TR) of simulations) using a commonly employed pairing of models. The procedures used are relevant to all marine larval dispersal models. It is shown how the results of these tests can inform the future set up and interpretation of ecological studies in this area. For example, an optimal arrangement of release locations spanning a release area could be deduced; the increased depth range spanned in deep-sea studies may necessitate the stratification of dispersal simulations with different numbers of release locations at different depths; no fewer than 52 releases per year should be used unless biologically informed; three years of simulations chosen based on climatic extremes may provide results with 90% similarity to five years of simulation; and this model setup is not appropriate for simulating rare dispersal events. A step-by-step process, summarising advice on the sensitivity testing procedure, is provided to inform all future unassisted ecologists looking to run a larval dispersal simulation. PMID

  8. Sensitivity of the STAT-VIEW rapid self-test and implications for use during acute HIV infection.

    Science.gov (United States)

    Boukli, Narjis; Boyd, Anders; Wendremaire, Noémie; Girard, Pierre-Marie; Bottero, Julie; Morand-Joubert, Laurence

    2017-08-23

    HIV testing is an important step towards diminishing incident infections. Rapid self-tests whose use is becoming more common in France could help increase access to testing, yet could fail to diagnose HIV during acute HIV infection (AHI). The aim of the present study was to evaluate HIV-detection sensitivity of a commonly used rapid self-test (STAT-VIEW HIV1/2), compared with another point-of-care rapid test (INSTI), among patients presenting with AHI. Individuals tested at Saint-Antoine Hospital (Paris, France) with negative or indeterminate western blot (WB) results and detectable HIV-RNA were included. Rapid tests were performed retrospectively on stored serum. Patients with and without reactive rapid tests were compared, while probability of having a reactive test was modelled across infection duration using logistic regression. Of the 40 patients with AHI, 23 (57.5%) had a reactive STAT-VIEW rapid test. Patients with non-reactive versus reactive tests had a significantly shorter median time since infection (p=0.01), time since onset of symptoms (p=0.009), higher proportion with Fiebig stage III versus IV (p=0.003), negative WB results (p=0.007), higher HIV-RNA levels (p=0.001) and lower CD4+ and CD8+ cell count (p=0.03, prapid self-test when performed on serum samples. Considering that detection sensitivity increased substantially over infection time, individuals should not rely on a negative result to accurately exclude HIV infection within at least 5 weeks of potential HIV exposure. Notwithstanding strong recommendations against rapid test use during AHI, some utility in detecting HIV is observed 5-12 weeks after transmission. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  9. Central sensitization phenomena after third molar surgery: A quantitative sensory testing study

    DEFF Research Database (Denmark)

    Jensen, T.S.; Norholt, S.E.; Svensson, P.

    2008-01-01

    Background: Surgical removal of third molars may carry a risk of developing persistent orofacial pain, and central sensitization appears to play an important role in the transition from acute to chronic pain. Aim: The aim of this study was to investigate sensitization (primarily central sensitiza......, which may play a role in the transition from acute to chronic pain in susceptible individuals. (c) 2007 European Federation of Chapters of the International Association for the Study of Pain. Published by Elsevier Ltd. All rights reserved Udgivelsesdato: 2008/1...

  10. Contrast sensitivity test and conventional and high frequency audiometry: information beyond that required to prescribe lenses and headsets

    Science.gov (United States)

    Comastri, S. A.; Martin, G.; Simon, J. M.; Angarano, C.; Dominguez, S.; Luzzi, F.; Lanusse, M.; Ranieri, M. V.; Boccio, C. M.

    2008-04-01

    In Optometry and in Audiology, the routine tests to prescribe correction lenses and headsets are respectively the visual acuity test (the first chart with letters was developed by Snellen in 1862) and conventional pure tone audiometry (the first audiometer with electrical current was devised by Hartmann in 1878). At present there are psychophysical non invasive tests that, besides evaluating visual and auditory performance globally and even in cases catalogued as normal according to routine tests, supply early information regarding diseases such as diabetes, hypertension, renal failure, cardiovascular problems, etc. Concerning Optometry, one of these tests is the achromatic luminance contrast sensitivity test (introduced by Schade in 1956). Concerning Audiology, one of these tests is high frequency pure tone audiometry (introduced a few decades ago) which yields information relative to pathologies affecting the basal cochlea and complements data resulting from conventional audiometry. These utilities of the contrast sensitivity test and of pure tone audiometry derive from the facts that Fourier components constitute the basis to synthesize stimuli present at the entrance of the visual and auditory systems; that these systems responses depend on frequencies and that the patient's psychophysical state affects frequency processing. The frequency of interest in the former test is the effective spatial frequency (inverse of the angle subtended at the eye by a cycle of a sinusoidal grating and measured in cycles/degree) and, in the latter, the temporal frequency (measured in cycles/sec). Both tests have similar duration and consist in determining the patient's threshold (corresponding to the inverse multiplicative of the contrast or to the inverse additive of the sound intensity level) for each harmonic stimulus present at the system entrance (sinusoidal grating or pure tone sound). In this article the frequencies, standard normality curves and abnormal threshold shifts

  11. A low-cost smartphone-based platform for highly sensitive point-of-care testing with persistent luminescent phosphors.

    Science.gov (United States)

    Paterson, Andrew S; Raja, Balakrishnan; Mandadi, Vinay; Townsend, Blane; Lee, Miles; Buell, Alex; Vu, Binh; Brgoch, Jakoah; Willson, Richard C

    2017-03-14

    Through their computational power and connectivity, smartphones are poised to rapidly expand telemedicine and transform healthcare by enabling better personal health monitoring and rapid diagnostics. Recently, a variety of platforms have been developed to enable smartphone-based point-of-care testing using imaging-based readout with the smartphone camera as the detector. Fluorescent reporters have been shown to improve the sensitivity of assays over colorimetric labels, but fluorescence readout necessitates incorporating optical hardware into the detection system, adding to the cost and complexity of the device. Here we present a simple, low-cost smartphone-based detection platform for highly sensitive luminescence imaging readout of point-of-care tests run with persistent luminescent phosphors as reporters. The extremely bright and long-lived emission of persistent phosphors allows sensitive analyte detection with a smartphone by a facile time-gated imaging strategy. Phosphors are first briefly excited with the phone's camera flash, followed by switching off the flash, and subsequent imaging of phosphor luminescence with the camera. Using this approach, we demonstrate detection of human chorionic gonadotropin using a lateral flow assay and the smartphone platform with strontium aluminate nanoparticles as reporters, giving a detection limit of ≈45 pg mL(-1) (1.2 pM) in buffer. Time-gated imaging on a smartphone can be readily adapted for sensitive and potentially quantitative testing using other point-of-care formats, and is workable with a variety of persistent luminescent materials.

  12. The relationship of speech intelligibility with hearing sensitivity, cognition, and perceived hearing difficulties varies for different speech perception tests

    Directory of Open Access Journals (Sweden)

    Antje eHeinrich

    2015-06-01

    Full Text Available Listeners vary in their ability to understand speech in noisy environments. Hearing sensitivity, as measured by pure-tone audiometry, can only partly explain these results, and cognition has emerged as another key concept. Although cognition relates to speech perception, the exact nature of the relationship remains to be fully understood. This study investigates how different aspects of cognition, particularly working memory and attention, relate to speech intelligibility for various tests.Perceptual accuracy of speech perception represents just one aspect of functioning in a listening environment. Activity and participation limits imposed by hearing loss, in addition to the demands of a listening environment, are also important and may be better captured by self-report questionnaires. Understanding how speech perception relates to self-reported aspects of listening forms the second focus of the study.Forty-four listeners aged between 50-74 years with mild SNHL were tested on speech perception tests differing in complexity from low (phoneme discrimination in quiet, to medium (digit triplet perception in speech-shaped noise to high (sentence perception in modulated noise; cognitive tests of attention, memory, and nonverbal IQ; and self-report questionnaires of general health-related and hearing-specific quality of life.Hearing sensitivity and cognition related to intelligibility differently depending on the speech test: neither was important for phoneme discrimination, hearing sensitivity alone was important for digit triplet perception, and hearing and cognition together played a role in sentence perception. Self-reported aspects of auditory functioning were correlated with speech intelligibility to different degrees, with digit triplets in noise showing the richest pattern. The results suggest that intelligibility tests can vary in their auditory and cognitive demands and their sensitivity to the challenges that auditory environments pose on

  13. Prevalence of benzocaine and lidocaine patch test sensitivity in Denmark: temporal trends and relevance

    DEFF Research Database (Denmark)

    Thyssen, Jacob P; Engkilde, Kåre; Menné, Torkil;

    2011-01-01

    BACKGROUND. Allergens included in the European baseline series should result in positive patch test reactions in at least 1% of a patch test population. Inclusion of local anaesthetics other than benzocaine in the baseline series has previously been debated.......BACKGROUND. Allergens included in the European baseline series should result in positive patch test reactions in at least 1% of a patch test population. Inclusion of local anaesthetics other than benzocaine in the baseline series has previously been debated....

  14. Sensitivity of C-Tb: a novel RD-1-specific skin test for the diagnosis of tuberculosis infection.

    Science.gov (United States)

    Hoff, Soren T; Peter, Jonathan G; Theron, Grant; Pascoe, Mellissa; Tingskov, Pernille N; Aggerbeck, Henrik; Kolbus, Daniel; Ruhwald, Morten; Andersen, Peter; Dheda, Keertan

    2016-03-01

    C-Tb, a novel Mycobacterium tuberculosis and 6-kDa early secretory antigenic target/10-kDa culture filtrate protein (ESAT-6/CFP-10)-specific skin test, has high specificity in bacille Calmette-Guerin-vaccinated healthy controls. However, the sensitivity of C-Tb has hitherto not been determined. The objective was to determine the sensitivity of C-Tb in patients with active tuberculosis (TB) in comparison with the tuberculin skin test (TST) and QuantiFERON-TB Gold In-Tube (QFT-GIT).C-Tb and TST were randomly administered in a double-blinded fashion to one or the other forearm in 253 patients with active TB with or without HIV co-infection. QFT-GIT testing was performed prior to skin testing.Using a receiver operating characteristic curve-derived cut-point of 5 mm, C-Tb sensitivity was similar to QFT-GIT (73.9 (95% CI 67.8-79.3) versus 75.1 (95% CI 69.3-80.2)), and similar in HIV-infected and HIV-uninfected patients (76.7 (95% CI 69.0-83.3) versus 69.5 (95% CI 59.2-78.5)). However, sensitivity was significantly diminished in HIV-infected patients with CD4 counts tuberculosis infection. Sensitivity was reduced only in HIV-infected patients with severe immunosuppression. Further studies in different settings are required to validate the proposed 5 mm cut-point. Copyright ©ERS 2016.

  15. Immunoassay-Based Drug Tests Are Inadequately Sensitive for Medication Compliance Monitoring in Patients Treated for Chronic Pain.

    Science.gov (United States)

    Snyder, Marion L; Fantz, Corrine R; Melanson, Stacy

    2017-02-01

    Enzyme immunoassays (EIA) have notable limitations for monitoring therapeutic compliance in pain management. Chromatography coupled with mass spectrometry provides definitive results and superior sensitivity and specificity over traditional EIA testing. To analyze and compare the sensitivity of EIA results together with known prescriptions to liquid chromatography-tandem mass spectrometry (LC-MS/MS) for monitoring drug use (and abuse) in patients treated for chronic pain. A total of 530 urine samples from patients being treated for chronic pain were studied. Pain management clinic in the United States. The samples were tested for a profile of chronic pain medications and illicit drugs with commercially available EIA kits followed by analysis with Agilent LC-MS/MS system. The EIAs exhibited poor sensitivity and high rates of false negative results in the pain management setting. For example, 21% of EIA for opiates show false negative results. Mass spectrometry methods were more sensitive, detected a broader range of drugs and metabolites, and could detect non-prescribed drug use and simulations in compliance. Patients do not always accurately report drug use information, and some drugs do not have EIA methods available for comparative purposes. Mass spectrometry is a more robust and reliable method for detection of drugs used in the pain management setting. Due to the extent of undisclosed use and abuse of medications and illicit drugs, LC-MS/MS testing is necessary for adequate and accurate drug detection. In addition, LC-MS/MS methods are superior in terms of sensitivity and number of compounds that can be screened, making this a better method for use in pain management. Key words: Pain management, enzyme immunoassays, mass spectrometry, urine drug testing, prescription status, compliance.

  16. 77 FR 52333 - International Workshop on Alternatives to the Murine Histamine Sensitization Test (HIST) for...

    Science.gov (United States)

    2012-08-29

    ... of animals in vaccine safety testing. The goal is to address the path toward global validation... challenges requiring frequent retesting, thereby increasing vaccine testing expense and animal usage. An... safety testing (Stokes et al., 2011). \\1\\ International Workshop on Alternative Methods to Reduce, Refine...

  17. Serological tests in leprosy. The sensitivity, specificity and predictive value of ELISA tests based on phenolic glycolipid antigens, and the implications for their use in epidemiological studies.

    Science.gov (United States)

    Burgess, P J; Fine, P E; Ponnighaus, J M; Draper, C

    1988-08-01

    This paper examines the sensitivity and specificity of two ELISA assays for IgM antibodies to Mycobacterium leprae, one employing natural phenolic glycolipid and the other employing a synthetic disaccharide glycoconjugate as antigen. Estimates of sensitivity and specificity are derived, based on a panel of sera from leprosy cases in Malawi and various non-leprosy controls from the UK. Though both assays were able to identify a high proportion of multibacillary patients, neither was able to detect a high proportion of paucibacillary patients without considerable loss of specificity. The implications of the inverse relationship between sensitivity and specificity are discussed with reference to the predictive value of such tests in such areas as Malawi, where the large majority of cases are paucibacillary.

  18. Distinguishing between learning and motivation in behavioral tests of the reinforcement sensitivity theory of personality.

    Science.gov (United States)

    Smillie, Luke D; Dalgleish, Len I; Jackson, Chris J

    2007-04-01

    According to Gray's (1973) Reinforcement Sensitivity Theory (RST), a Behavioral Inhibition System (BIS) and a Behavioral Activation System (BAS) mediate effects of goal conflict and reward on behavior. BIS functioning has been linked with individual differences in trait anxiety and BAS functioning with individual differences in trait impulsivity. In this article, it is argued that behavioral outputs of the BIS and BAS can be distinguished in terms of learning and motivation processes and that these can be operationalized using the Signal Detection Theory measures of response-sensitivity and response-bias. In Experiment 1, two measures of BIS-reactivity predicted increased response-sensitivity under goal conflict, whereas one measure of BAS-reactivity predicted increased response-sensitivity under reward. In Experiment 2, two measures of BIS-reactivity predicted response-bias under goal conflict, whereas a measure of BAS-reactivity predicted motivation response-bias under reward. In both experiments, impulsivity measures did not predict criteria for BAS-reactivity as traditionally predicted by RST.

  19. Tests of methods and software for set-valued model calibration and sensitivity analyses

    NARCIS (Netherlands)

    Janssen PHM; Sanders R; CWM

    1995-01-01

    Testen worden besproken die zijn uitgevoerd op methoden en software voor calibratie middels 'rotated-random-scanning', en voor gevoeligheidsanalyse op basis van de 'dominant direction analysis' en de 'generalized sensitivity analysis'. Deze technieken werden recentel

  20. Determining pancreatic β-cell compensation for changing insulin sensitivity using an oral glucose tolerance test

    DEFF Research Database (Denmark)

    Solomon, Thomas; Malin, Steven K; Karstoft, Kristian

    2014-01-01

    Plasma glucose, insulin, and C-peptide responses during an OGTT are informative for both research and clinical practice in type 2 diabetes. The aim of this study was to use such information to determine insulin sensitivity and insulin secretion so as to calculate an oral glucose disposition index...