WorldWideScience

Sample records for preliminary regulatory determinations

  1. 45 CFR 150.217 - Preliminary determination.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Preliminary determination. 150.217 Section 150.217... Are Failing To Substantially Enforce HIPAA Requirements § 150.217 Preliminary determination. If, at... designees). (b) Notifies the State of CMS's preliminary determination that the State has failed to...

  2. Preliminary Determination of Epicenters (PDE) Bulletin

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The NEIC global earthquake bulletin is called the Preliminary Determination of Epicenters or PDE, and is one of many discrete products in the ANSS Comprehensive...

  3. 78 FR 63176 - Notice of Preliminary Determination of a Qualifying Conduit Hydropower Facility and Soliciting...

    Science.gov (United States)

    2013-10-23

    ... Energy Regulatory Commission Notice of Preliminary Determination of a Qualifying Conduit Hydropower... hydropower facility, pursuant to section 30 of the Federal Power Act, as amended by section 4 of the Hydropower Regulatory Efficiency Act of 2013 (HREA). The 22 kW Orchard City Water Treatment Plant...

  4. 78 FR 69847 - North Side Canal Company; Notice of Preliminary Determination of a Qualifying Conduit Hydropower...

    Science.gov (United States)

    2013-11-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission North Side Canal Company; Notice of Preliminary Determination of a Qualifying Conduit Hydropower Facility and Soliciting Comments and Motions To Intervene On November 5, 2013, North Side Canal Company, filed a notice...

  5. 78 FR 62351 - North Side Canal Company; Notice of Preliminary Determination of a Qualifying Conduit Hydropower...

    Science.gov (United States)

    2013-10-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission North Side Canal Company; Notice of Preliminary Determination of a Qualifying Conduit Hydropower Facility and Soliciting Comments and Motions To Intervene On October 3, 2013, North Side Canal Company, filed a notice...

  6. 78 FR 66355 - Pleasant Grove City, UT; Notice of Preliminary Determination of a Qualifying Conduit Hydropower...

    Science.gov (United States)

    2013-11-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Pleasant Grove City, UT; Notice of Preliminary Determination of a Qualifying.... Applicant Contact: Dean Lundell, Pleasant Grove City, Utah, 70 South 100 East, Pleasant Grove, UT...

  7. Establishment of preliminary regulatory network of TRPV1 and related cytokines

    Directory of Open Access Journals (Sweden)

    Jianhua Zhang

    2017-03-01

    Full Text Available Our purpose was to investigate the regulatory mechanism of TRPV1 and related cytokines on children bronchial asthma. TRPV1 mRNA level and two SNP genotypes of children in case group and control group were detected by real-time quantitative PCR. Western blot and ELISA were used to measure the levels of cytokines like IgE, IL-2, etc. Their correlations were analyzed by Logistic regression and KEGG analysis. Moreover, tertiary structure of protein and miRNA binding sites were also predicted by online tools. Case group was obviously different from control group in TRPV1 mRNA level, the two SNP genotypes distribution and the related cytokines levels. Logistic regression analysis further demonstrated that TRPV1 mRNA level, EOS, IL-4 and IL-5 may be risk factors for children bronchial asthma. And based on that, the preliminary regulatory network of children bronchial asthma was drawn. What’s more, mutation of rs4790521 and rs4790522 in TRPV1 gene both induced its corresponding miRNA binding site’s change. The preliminary regulatory network of TRPV1 and related cytokines on children bronchial asthma established in this study provides certain theoretical basis for pathogenesis and treatment of children bronchial asthma.

  8. Preliminary Study on the Establishment of Regulatory Infrastructure for a Commercial SMART Licensing

    Energy Technology Data Exchange (ETDEWEB)

    Yune, Young Gill; Roh, Kyung Wan; Kang, Dong Gu; Kim, Hho Jung; Jo, Jong Chull [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2007-10-15

    The SMART, an integral type of PWR with the capacity of 330MWth, has been developed for multi-purposes such as seawater desalination, ship propulsion, and district heating in Korea since early 1990s. The basic design of the SMART had been completed in 2002. For the demonstration of the safety and performance of the SMART, a project to construct a 1/5 scaled-down prototype reactor with capacity of 65MWth, called as SMART-P(SMART Pilot Plant), has been performed from 2002 to 2006. However, in 2006, the project to construct the SMART-P was replaced with a preliminary project to develop a commercial SMART in order to advance commercialization of the SMART. Since the SMART is the first commercial reactor adopting the integral design concept and new system/components such as passive residual heat removal system, canned motor pump, and helical tube steam generator in Korea, some verification tests need to be performed to demonstrate the safety and performance of the SMART. Also, since several new design computer codes that have not yet been confirmed by the regulatory body are expected to be used in the design, some validation tests should be performed to demonstrate their applicability for important accident phenomena. In order to carry out the SMART development project satisfactorily and to prevent any undesirable delay of licensing process, it is necessary to establish a well-planned verification test program in advance through the early identification of the scope and items of the verification tests. Also, the issues for which either policy decision-makings or detailed technical evaluations are needed should be identified in an early stage of design, and the regulatory positions for the issues should be provided either timely or in advance. Advance identification of regulatory requirements/guides to be amended or newly developed enables to provide regulatory directions for such items in the early stage of design. The objective of this paper is to introduce the current

  9. Advanced stellar compass - Onboard autonomous orbit determination, preliminary performance

    DEFF Research Database (Denmark)

    Betto, Maurizio; Jørgensen, John Leif; Jørgensen, Peter Siegbjørn

    2004-01-01

    of this instrument, the authors have devised a method to determine the orbit of a spacecraft autonomously, onboard, and without a priori knowledge of any kind. The solution is robust and fast. This paper presents the preliminary performance obtained during the ground testing in August 2002 at the Mauna Kea...... be implemented into an ASC without degrading the attitude measurements; and (4) to identify the areas of development and consolidation. The results obtained are very encouraging....

  10. Primate phylogeny studied by comparative determinant analysis. A preliminary report.

    Science.gov (United States)

    Bauer, K

    1993-01-01

    In this preliminary report the divergence times for the major primate groups are given, calculated from a study by comparative determinant analysis of 69 proteins (equaling 0.1% of the whole genetic information). With an origin of the primate order set at 80 million years before present, the ages of the last common ancestors (LCAs) of man and the major primate groups obtained this way are as follows: Pan troglodytes 5.2; Gorilla gorilla 7.4; Pongo pygmaeus 19.2; Hylobates lar 20.3; Old World monkeys 31.4; Lagothrix lagotricha 46.0; Cebus albifrons 59.5; three lemur species 67.0, and Galago crassicaudatus 73.3 million years. The LCA results and the approach are shortly discussed. A full account of this extended investigation including results on nonprimate mammals and on the determinant structures and the immunologically derived evolutionary rates of the proteins analyzed will be published elsewhere.

  11. 75 FR 19406 - Determination of Regulatory Review Period for Purposes of Patent Extension; AFINITOR

    Science.gov (United States)

    2010-04-14

    ... advanced renal cell carcinoma after failure of treatment with sunitinib or sorafenib. Subsequent to this... HUMAN SERVICES Food and Drug Administration Determination of Regulatory Review Period for Purposes of... and Drug Administration (FDA) has determined the regulatory review period for AFINITOR and...

  12. Determinants of Effective Information Transfer in International Regulatory Standards Adoption

    Science.gov (United States)

    Popescu, Denisa

    2010-01-01

    The role of international regulatory standards within the current global environment has become of the most importance. The age of the global system and free market capitalism carried us into the unprecedented age of regulations, and standard setting. Regulations are now becoming the emerging mode of global governance. This study focuses on…

  13. 37 CFR 1.488 - Determination of unity of invention before the International Preliminary Examining Authority.

    Science.gov (United States)

    2010-07-01

    ... invention before the International Preliminary Examining Authority. 1.488 Section 1.488 Patents, Trademarks... Determination of unity of invention before the International Preliminary Examining Authority. (a) Before... requirement of unity of invention as set forth in § 1.475. (b) If the International Preliminary Examining...

  14. Advanced stellar compass onboard autonomous orbit determination, preliminary performance.

    Science.gov (United States)

    Betto, Maurizio; Jørgensen, John L; Jørgensen, Peter S; Denver, Troelz

    2004-05-01

    Deep space exploration is in the agenda of the major space agencies worldwide; certainly the European Space Agency (SMART Program) and the American NASA (New Millennium Program) have set up programs to allow the development and the demonstration of technologies that can reduce the risks and the cost of deep space missions. From past experience, it appears that navigation is the Achilles heel of deep space missions. Performed on ground, this imposes considerable constraints on the entire system and limits operations. This makes it is very expensive to execute, especially when the mission lasts several years and, furthermore, it is not failure tolerant. Nevertheless, to date, ground navigation has been the only viable solution. The technology breakthrough of advanced star trackers, like the advanced stellar compass (ASC), might change this situation. Indeed, exploiting the capabilities of this instrument, the authors have devised a method to determine the orbit of a spacecraft autonomously, onboard, and without a priori knowledge of any kind. The solution is robust and fast. This paper presents the preliminary performance obtained during the ground testing in August 2002 at the Mauna Kea Observatories. The main goals were: (1) to assess the robustness of the method in solving autonomously, onboard, the position lost-in-space problem; (2) to assess the preliminary accuracy achievable with a single planet and a single observation; (3) to verify the autonomous navigation (AutoNav) module could be implemented into an ASC without degrading the attitude measurements; and (4) to identify the areas of development and consolidation. The results obtained are very encouraging.

  15. Genomic analysis reveals major determinants of cis-regulatory variation in Capsella grandiflora.

    Science.gov (United States)

    Steige, Kim A; Laenen, Benjamin; Reimegård, Johan; Scofield, Douglas G; Slotte, Tanja

    2017-01-31

    Understanding the causes of cis-regulatory variation is a long-standing aim in evolutionary biology. Although cis-regulatory variation has long been considered important for adaptation, we still have a limited understanding of the selective importance and genomic determinants of standing cis-regulatory variation. To address these questions, we studied the prevalence, genomic determinants, and selective forces shaping cis-regulatory variation in the outcrossing plant Capsella grandiflora We first identified a set of 1,010 genes with common cis-regulatory variation using analyses of allele-specific expression (ASE). Population genomic analyses of whole-genome sequences from 32 individuals showed that genes with common cis-regulatory variation (i) are under weaker purifying selection and (ii) undergo less frequent positive selection than other genes. We further identified genomic determinants of cis-regulatory variation. Gene body methylation (gbM) was a major factor constraining cis-regulatory variation, whereas presence of nearby transposable elements (TEs) and tissue specificity of expression increased the odds of ASE. Our results suggest that most common cis-regulatory variation in C. grandiflora is under weak purifying selection, and that gene-specific functional constraints are more important for the maintenance of cis-regulatory variation than genome-scale variation in the intensity of selection. Our results agree with previous findings that suggest TE silencing affects nearby gene expression, and provide evidence for a link between gbM and cis-regulatory constraint, possibly reflecting greater dosage sensitivity of body-methylated genes. Given the extensive conservation of gbM in flowering plants, this suggests that gbM could be an important predictor of cis-regulatory variation in a wide range of plant species.

  16. Sex determination strategies in 2012: towards a common regulatory model?

    Science.gov (United States)

    2012-01-01

    Sex determination is a complicated process involving large-scale modifications in gene expression affecting virtually every tissue in the body. Although the evolutionary origin of sex remains controversial, there is little doubt that it has developed as a process of optimizing metabolic control, as well as developmental and reproductive functions within a given setting of limited resources and environmental pressure. Evidence from various model organisms supports the view that sex determination may occur as a result of direct environmental induction or genetic regulation. The first process has been well documented in reptiles and fish, while the second is the classic case for avian species and mammals. Both of the latter have developed a variety of sex-specific/sex-related genes, which ultimately form a complete chromosome pair (sex chromosomes/gonosomes). Interestingly, combinations of environmental and genetic mechanisms have been described among different classes of animals, thus rendering the possibility of a unidirectional continuous evolutionary process from the one type of mechanism to the other unlikely. On the other hand, common elements appear throughout the animal kingdom, with regard to a) conserved key genes and b) a central role of sex steroid control as a prerequisite for ultimately normal sex differentiation. Studies in invertebrates also indicate a role of epigenetic chromatin modification, particularly with regard to alternative splicing options. This review summarizes current evidence from research in this hot field and signifies the need for further study of both normal hormonal regulators of sexual phenotype and patterns of environmental disruption. PMID:22357269

  17. Sex determination strategies in 2012: towards a common regulatory model?

    Directory of Open Access Journals (Sweden)

    Angelopoulou Roxani

    2012-02-01

    Full Text Available Abstract Sex determination is a complicated process involving large-scale modifications in gene expression affecting virtually every tissue in the body. Although the evolutionary origin of sex remains controversial, there is little doubt that it has developed as a process of optimizing metabolic control, as well as developmental and reproductive functions within a given setting of limited resources and environmental pressure. Evidence from various model organisms supports the view that sex determination may occur as a result of direct environmental induction or genetic regulation. The first process has been well documented in reptiles and fish, while the second is the classic case for avian species and mammals. Both of the latter have developed a variety of sex-specific/sex-related genes, which ultimately form a complete chromosome pair (sex chromosomes/gonosomes. Interestingly, combinations of environmental and genetic mechanisms have been described among different classes of animals, thus rendering the possibility of a unidirectional continuous evolutionary process from the one type of mechanism to the other unlikely. On the other hand, common elements appear throughout the animal kingdom, with regard to a conserved key genes and b a central role of sex steroid control as a prerequisite for ultimately normal sex differentiation. Studies in invertebrates also indicate a role of epigenetic chromatin modification, particularly with regard to alternative splicing options. This review summarizes current evidence from research in this hot field and signifies the need for further study of both normal hormonal regulators of sexual phenotype and patterns of environmental disruption.

  18. 40 CFR 761.257 - Determining the regulatory status of sampled pipe.

    Science.gov (United States)

    2010-07-01

    ... sampled pipe. 761.257 Section 761.257 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Samples § 761.257 Determining the regulatory status of sampled pipe. (a) For purposes of removal for disposal of a pipe segment that has been sampled, the sample results for that segment determines its PCB...

  19. Preliminary investigation of relations between young students' self-regulatory strategies and their metacognitive experiences.

    Science.gov (United States)

    Dermitzaki, Irini

    2005-12-01

    The present study investigated second-graders' self-regulative behav ior during task engagement and its relations to performance and to students' on-line metacognitive experiences. Participants were 25 individually examined Greek second graders (13 boys and 12 girls; M age: 7.6 yr., SD = 0.2). Students' use of cognitive, metacognitive, and motivational regulatory strategies while performing a cognitive task were directly observed and recorded by two independent observers. Students' task-specific performance was also evaluated. Finally, students' feeling of satisfaction with the solution produced, their estimate of effort expenditure, and estimate of the solution's correctness were assessed. Analysis showed these second grade students' use of self-regulatory strategies and feeling of satisfaction were significantly associated with their performance. However, metacognitive experiences reported after the solution were only slightly related to the students' actual self-regulative behavior during the task, implying that the relations of students' regulatory efforts with their metacognitive processes are still developing at such a young age.

  20. A boolean model of the cardiac gene regulatory network determining first and second heart field identity.

    Directory of Open Access Journals (Sweden)

    Franziska Herrmann

    Full Text Available Two types of distinct cardiac progenitor cell populations can be identified during early heart development: the first heart field (FHF and second heart field (SHF lineage that later form the mature heart. They can be characterized by differential expression of transcription and signaling factors. These regulatory factors influence each other forming a gene regulatory network. Here, we present a core gene regulatory network for early cardiac development based on published temporal and spatial expression data of genes and their interactions. This gene regulatory network was implemented in a Boolean computational model. Simulations reveal stable states within the network model, which correspond to the regulatory states of the FHF and the SHF lineages. Furthermore, we are able to reproduce the expected temporal expression patterns of early cardiac factors mimicking developmental progression. Additionally, simulations of knock-down experiments within our model resemble published phenotypes of mutant mice. Consequently, this gene regulatory network retraces the early steps and requirements of cardiogenic mesoderm determination in a way appropriate to enhance the understanding of heart development.

  1. A Boolean Model of the Cardiac Gene Regulatory Network Determining First and Second Heart Field Identity

    Science.gov (United States)

    Zhou, Dao; Kestler, Hans A.; Kühl, Michael

    2012-01-01

    Two types of distinct cardiac progenitor cell populations can be identified during early heart development: the first heart field (FHF) and second heart field (SHF) lineage that later form the mature heart. They can be characterized by differential expression of transcription and signaling factors. These regulatory factors influence each other forming a gene regulatory network. Here, we present a core gene regulatory network for early cardiac development based on published temporal and spatial expression data of genes and their interactions. This gene regulatory network was implemented in a Boolean computational model. Simulations reveal stable states within the network model, which correspond to the regulatory states of the FHF and the SHF lineages. Furthermore, we are able to reproduce the expected temporal expression patterns of early cardiac factors mimicking developmental progression. Additionally, simulations of knock-down experiments within our model resemble published phenotypes of mutant mice. Consequently, this gene regulatory network retraces the early steps and requirements of cardiogenic mesoderm determination in a way appropriate to enhance the understanding of heart development. PMID:23056457

  2. Determinants of Trade Credit: A Preliminary Analysis on Construction Sector

    Directory of Open Access Journals (Sweden)

    Nicoleta Barbuta-Misu

    2016-07-01

    Full Text Available This paper introduces a preliminary analysis of the correlations between trade credit and some selected measures of financial performance for a sample of 958 firms acting in the construction sector. The examined period covers 2004-2013. The sample derived from Amadeus database contains firms that have sold and bought on credit. Results showed that larger firms offered and used more credit than counterparties. Firms offered and used in same time credit, but not in same level. Firms with higher return on assets and profit margin used and offered less credit from suppliers, respectively to clients. Moreover, more liquid firms used less trade payables.

  3. 77 FR 26556 - Determination of Regulatory Review Period for Purposes of Patent Extension; EQUIDONE GEL

    Science.gov (United States)

    2012-05-04

    ... Patent Extension; EQUIDONE GEL AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) has determined the regulatory review period for EQUIDONE GEL and is....S.C. 156(g)(4)(B). FDA approved for marketing the animal drug product EQUIDONE GEL...

  4. 78 FR 62766 - Self-Regulatory Organizations; NYSE MKT LLC; Order Instituting Proceedings To Determine Whether...

    Science.gov (United States)

    2013-10-22

    ... COMMISSION Self-Regulatory Organizations; NYSE MKT LLC; Order Instituting Proceedings To Determine Whether To.... Introduction On June 21, 2013, NYSE MKT LLC (``NYSE MKT'') filed with the Securities and Exchange Commission...-4 ] thereunder,\\2\\ a proposed rule change to amend NYSE MKT Rule 965NY to revise the...

  5. Motivational and Affective Determinants of Self-Regulatory Strategy Use in Elementary School Mathematics

    Science.gov (United States)

    Chatzistamatiou, Mariza; Dermitzaki, Irini; Efklides, Anastasia; Leondari, Angeliki

    2015-01-01

    The aim of the study was to investigate the relationships between elementary students' reported use of self-regulatory strategies in mathematics and their motivational and affective determinants. Participants of the study were 344 fifth- and sixth-grade Greek students. Students were asked to complete self-reported measures regarding the strategies…

  6. Preliminary studies to determine the shelf life of HEPA filters

    Energy Technology Data Exchange (ETDEWEB)

    Gilbert, H.; Fretthold, J.K.; Rainer, F. [Lawrence Livermore National Laboratory, CA (United States)] [and others

    1995-02-01

    We have completed a preliminary study using filter media tests and filter qualification tests to investigate the effect of shelf-life on HEPA filter performance. Our media studies showed that the tensile strength decreased with age, but the data were not sufficient to establish a shelf-life. Thermogravimetric analyses demonstrated that one manufacturer had media with low tensile strength due to insufficient binder. The filter qualification tests (heated air and overpressure) conducted on different aged filters showed that filter age is not the primary factor affecting filter performance; materials and the construction design have a greater effect. An unexpected finding of our study was that sub-standard HEPA filters have been installed in DOE facilities despite existing regulations and filter qualification tests. We found that the filter with low tensile strength failed the overpressure test. The same filter had passed the heated air test, but left the filter so structurally weak, it was prone to blow-out. We recommend that DOE initiate a filter qualification program to prevent this occurrence.

  7. 77 FR 46044 - Steel Wire Garment Hangers From the Socialist Republic of Vietnam: Preliminary Determination of...

    Science.gov (United States)

    2012-08-02

    ... Wire Garment Hangers From the Socialist Republic of Vietnam: Preliminary Determination of Sales at Less... preliminarily determine that steel wire garment hangers from the Socialist Republic of Vietnam (``Vietnam'') are... (``AD'') petition concerning imports of steel wire garment hangers from Vietnam filed in proper form...

  8. Intercomparison run for uranium and tritium determination in urine samples, organised by Nuclear Regulatory Authority, Argentina

    CERN Document Server

    Serdeiro, N H; Equillor, H E

    2003-01-01

    The Nuclear Regulatory Authority (ARN), Argentina, has carried out an intercomparison run for tritium and uranium determination in urine, in November 2002. The aim of this exercise was to assess the performance of the laboratories that usually inform these radionuclides and to provide technical support in order to have an appropriate occupational monitoring in vitro. In the present work, the results of the intercomparison and the assessment of each laboratory are published.

  9. Determinants of Regulatory Burdens on Non-listed Small Corporations in Australia: Perceptions of Small Corporations’ Owners/Managers

    Directory of Open Access Journals (Sweden)

    Yongqiang Li

    2014-09-01

    Full Text Available Small corporations are the engine room whilst the forgotten corner of the Australian economy. Regulatory burdens are hampering the small corporations from performing to their optimal, which consequently impairs the economic growth of the nation. For policy decision makers, quantifying the regulatory compliance cost is the first priority for evidence-based de-regulatory reforms. Thus, policy options proposed are of practical imperative to future de-regulation reforms. Prior research supporting the estimation and determination of regulatory compliance cost are at a dearth. This paper fills the gap by estimating the regulatory compliance costs of small corporations using the firm level survey data. A non-parametric logit model, Generalised Ordered Logit/Partial Proportional Odds Model (gonlogit2, is developed to estimate the impacts of determinants on regulatory costs. The paper concluded with a discussion of policy implications and future research directions.

  10. 78 FR 71565 - Steel Threaded Rod from India: Postponement of Preliminary Determination of Antidumping Duty...

    Science.gov (United States)

    2013-11-29

    ... International Trade Administration Steel Threaded Rod from India: Postponement of Preliminary Determination of...'') published a notice of initiation of the antidumping duty investigation of steel threaded rod from India.\\1... later than December 20, 2013. \\1\\ See Steel Threaded Rod From India and Thailand: Initiation...

  11. Innovation of a Regulatory Mechanism Modulating Semi-determinate Stem Growth through Artificial Selection in Soybean.

    Directory of Open Access Journals (Sweden)

    Yunfeng Liu

    2016-01-01

    Full Text Available It has been demonstrated that Terminal Flowering 1 (TFL1 in Arabidopsis and its functional orthologs in other plants specify indeterminate stem growth through their specific expression that represses floral identity genes in shoot apical meristems (SAMs, and that the loss-of-function mutations at these functional counterparts result in the transition of SAMs from the vegetative to reproductive state that is essential for initiation of terminal flowering and thus formation of determinate stems. However, little is known regarding how semi-determinate stems, which produce terminal racemes similar to those observed in determinate plants, are specified in any flowering plants. Here we show that semi-determinacy in soybean is modulated by transcriptional repression of Dt1, the functional ortholog of TFL1, in SAMs. Such repression is fulfilled by recently enabled spatiotemporal expression of Dt2, an ancestral form of the APETALA1/FRUITFULL orthologs, which encodes a MADS-box factor directly binding to the regulatory sequence of Dt1. In addition, Dt2 triggers co-expression of the putative SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (GmSOC1 in SAMs, where GmSOC1 interacts with Dt2, and also directly binds to the Dt1 regulatory sequence. Heterologous expression of Dt2 and Dt1 in determinate (tfl1 Arabidopsis mutants enables creation of semi-determinacy, but the same forms of the two genes in the tfl1 and soc1 background produce indeterminate stems, suggesting that Dt2 and SOC1 both are essential for transcriptional repression of Dt1. Nevertheless, the expression of Dt2 is unable to repress TFL1 in Arabidopsis, further demonstrating the evolutionary novelty of the regulatory mechanism underlying stem growth in soybean.

  12. Searching for Logistics and Regulatory Determinants Affecting Overseas Direct Purchase: An Empirical Cross-National Study

    Directory of Open Access Journals (Sweden)

    Hyuksoo Cho

    2017-03-01

    Full Text Available Cross-border e-commerce has been very successful in the last decade. Merchants and consumers have been encouraged to participate in e-commerce, including B2C or B2B. B2C is not limited to a domestic market anymore. Consumers across countries are interested in overseas direct purchases. They are willing to purchase products from major online shopping sites such as Amazon and eBay. We aim at gaining a better understanding of overseas direct purchases. Determinants of overseas direct purchases based on cross-national data are identified. Accordingly, we investigate logistics and regulatory determinants. Furthermore, external environments such as regulatory institutions and globalization are discussed in terms of overseas direct purchases. This study incorporates theoretical foundations into empirical findings. Specifically, the institutional theory and the resource-based view are applied to explain the internal and external determinants to increase overseas direct purchases. We conduct an empirical test using panel data for each country to identify the various determinants associated with overseas direct purchases.

  13. Final Regulatory Determination for Special Wastes From Mineral Processing (Mining Waste Exclusion) - Federal Register Notice, June 13, 1991

    Science.gov (United States)

    This action presents the Agency's final regulatory determination required by section 3001(b)(3)(C) of the Resource Conservation and Recovery Act (RCRA) for 20 special wastes from the processing of ores and minerals.

  14. Gene Regulatory Network Analysis Reveals Differences in Site-specific Cell Fate Determination in Mammalian Brain

    Directory of Open Access Journals (Sweden)

    Gokhan eErtaylan

    2014-12-01

    Full Text Available Neurogenesis - the generation of new neurons - is an ongoing process that persists in the adult mammalian brain of several species, including humans. In this work we analyze two discrete brain regions: the subventricular zone (SVZ lining the walls of the lateral ventricles; and the subgranular zone (SGZ of the dentate gyrus of the hippocampus in mice and shed light on the SVZ and SGZ specific neurogenesis. We propose a computational model that relies on the construction and analysis of region specific gene regulatory networks from the publicly available data on these two regions. Using this model a number of putative factors involved in neuronal stem cell (NSC identity and maintenance were identified. We also demonstrate potential gender and niche-derived differences based on cell surface and nuclear receptors via Ar, Hif1a and Nr3c1.We have also conducted cell fate determinant analysis for SVZ NSC populations to Olfactory Bulb interneurons and SGZ NSC populations to the granule cells of the Granular Cell Layer. We report thirty-one candidate cell fate determinant gene pairs, ready to be validated. We focus on Ar - Pax6 in SVZ and Sox2 - Ncor1 in SGZ. Both pairs are expressed and localized in the suggested anatomical structures as shown by in situ hybridization and found to physically interact.Finally, we conclude that there are fundamental differences between SGZ and SVZ neurogenesis. We argue that these regulatory mechanisms are linked to the observed differential neurogenic potential of these regions. The presence of nuclear and cell surface receptors in the region specific regulatory circuits indicate the significance of niche derived extracellular factors, hormones and region specific factors such as the oxygen sensitivity, dictating SGZ and SVZ specific neurogenesis.

  15. 77 FR 46055 - Steel Wire Garment Hangers From Taiwan: Preliminary Determination of Sales at Less Than Fair Value

    Science.gov (United States)

    2012-08-02

    ... Wire Garment Hangers From Taiwan: Preliminary Determination of Sales at Less Than Fair Value AGENCY.... Department of Commerce (the ``Department'') preliminarily determines that steel wire garment hangers... Department received an antidumping duty (``AD'') petition concerning imports of steel wire garment...

  16. ANSI/ASHRAE/IESNA Standard 90.1-2007 Preliminary Qualitative Determination

    Energy Technology Data Exchange (ETDEWEB)

    Halverson, Mark A.; Liu, Bing; Richman, Eric E.; Winiarski, David W.

    2010-05-25

    A preliminary qualitative analysis of all addenda to ANSI/ASHRAE/IESNA Standard 90.1-2004 that were included in ANSI/ASHRAE/IESNA Standard 90.1-2007 was conducted. All 44 addenda processed by ASHRAE in the creation of Standard 90.1-2007 from Standard 90.1-2004 were evaluated by DOE for their impact on energy efficiency. DOE preliminarily determined whether that addenda would have a positive, neutral, or negative impact on overall building efficiency.

  17. ANSI/ASHRAE/IESNA Standard 90.1-2007 Preliminary Qualitative Determination

    Energy Technology Data Exchange (ETDEWEB)

    Halverson, Mark A.; Liu, Bing; Richman, Eric E.; Winiarski, David W.

    2010-05-25

    A preliminary qualitative analysis of all addenda to ANSI/ASHRAE/IESNA Standard 90.1-2004 that were included in ANSI/ASHRAE/IESNA Standard 90.1-2007 was conducted. All 44 addenda processed by ASHRAE in the creation of Standard 90.1-2007 from Standard 90.1-2004 were evaluated by DOE for their impact on energy efficiency. DOE preliminarily determined whether that addenda would have a positive, neutral, or negative impact on overall building efficiency.

  18. Preliminary results and analyses of using IGS GPS data to determine global ionospheric TEC

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Using the spherical harmonic (SH) function model and the dual frequency GPS data of 139 International GPS Service (IGS) stations for July 15 of 2000, the global ionospheric total electron content (TEC) is calculated and the basic method is investigated. Here, preliminary results are reported and the problems and difficulties to be solved for using GPS data to determine the global ionospheric TEC are discussed.

  19. A motivational determinant of facial emotion recognition: regulatory focus affects recognition of emotions in faces.

    Science.gov (United States)

    Sassenrath, Claudia; Sassenberg, Kai; Ray, Devin G; Scheiter, Katharina; Jarodzka, Halszka

    2014-01-01

    Two studies examined an unexplored motivational determinant of facial emotion recognition: observer regulatory focus. It was predicted that a promotion focus would enhance facial emotion recognition relative to a prevention focus because the attentional strategies associated with promotion focus enhance performance on well-learned or innate tasks - such as facial emotion recognition. In Study 1, a promotion or a prevention focus was experimentally induced and better facial emotion recognition was observed in a promotion focus compared to a prevention focus. In Study 2, individual differences in chronic regulatory focus were assessed and attention allocation was measured using eye tracking during the facial emotion recognition task. Results indicated that the positive relation between a promotion focus and facial emotion recognition is mediated by shorter fixation duration on the face which reflects a pattern of attention allocation matched to the eager strategy in a promotion focus (i.e., striving to make hits). A prevention focus did not have an impact neither on perceptual processing nor on facial emotion recognition. Taken together, these findings demonstrate important mechanisms and consequences of observer motivational orientation for facial emotion recognition.

  20. ANSI/ASHRAE/IESNA Standard 90.1-2010 Preliminary Determination Quantitative Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Halverson, Mark A.; Liu, Bing; Rosenberg, Michael I.

    2010-11-01

    The United States (U.S.) Department of Energy (DOE) conducted a preliminary quantitative analysis to assess whether buildings constructed according to the requirements of the American National Standards Institute (ANSI)/American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE)/Illuminating Engineering Society of North America (IESNA) Standard 90.1-2010 (ASHRAE Standard 90.1-2010, Standard 90.1-2010, or 2010 edition) would result in energy savings compared with buildings constructed to ANSI/ASHRAE/IESNA Standard 90.1-2007(ASHRAE Standard 90.1-2007, Standard 90.1-2007, or 2007 edition). The preliminary analysis considered each of the 109 addenda to ASHRAE Standard 90.1-2007 that were included in ASHRAE Standard 90.1-2010. All 109 addenda processed by ASHRAE in the creation of Standard 90.1-2010 from Standard 90.1-2007 were reviewed by DOE, and their combined impact on a suite of 16 building prototype models in 15 ASHRAE climate zones was considered. Most addenda were deemed to have little quantifiable impact on building efficiency for the purpose of DOE’s preliminary determination. However, out of the 109 addenda, 34 were preliminarily determined to have measureable and quantifiable impact.

  1. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in the United States. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D.A.; Weaver, C.L.; Gallagher, K.C.; Hejna, D.; Rielley, K.J.

    1980-01-01

    This report is one of a series of preliminary reports describing the laws and regulatory programs of the United States and each of the 50 states affecting the siting and operation of energy generating facilities likely to be used in Integrated Community Energy Systems (ICES). Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES. This report describes laws and regulatory programs in the United States. Subsequent reports will (1) describe public utility rate regulatory procedures and practices as they might affect an ICES, (2) analyze each of the aforementioned regulatory programs to identify impediments to the development of ICES, and (3) recommend potential changes in legislation and regulatory practices and procedures to overcome such impediments.

  2. 78 FR 75544 - Prestressed Concrete Steel Rail Tie Wire From Mexico: Preliminary Determination of Sales at Less...

    Science.gov (United States)

    2013-12-12

    ... International Trade Administration Prestressed Concrete Steel Rail Tie Wire From Mexico: Preliminary.... SUMMARY: The Department of Commerce (``Department'') preliminarily determines that prestressed concrete... prestressed tendons in concrete railroad ties (``PC tie wire''). High carbon steel is defined as steel...

  3. 75 FR 54345 - Determination of Regulatory Review Period for Purposes of Patent Extension; BRYAN CERVICAL DISC...

    Science.gov (United States)

    2010-09-07

    ... and an approval phase. For medical devices, the testing phase begins with a clinical investigation of... length of a regulatory review period for a medical device will include all of the testing phase and... Patent and Trademark Office that this medical device had undergone a regulatory review period and...

  4. ANSI/ASHRAE/IES Standard 90.1-2013 Preliminary Determination: Qualitative Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Halverson, Mark A.; Hart, Reid; Athalye, Rahul A.; Rosenberg, Michael I.; Richman, Eric E.; Winiarski, David W.

    2014-03-01

    Section 304(b) of the Energy Conservation and Production Act (ECPA), as amended, requires the Secretary of Energy to make a determination each time a revised version of ASHRAE Standard 90.1 is published with respect to whether the revised standard would improve energy efficiency in commercial buildings. When the U.S. Department of Energy (DOE) issues an affirmative determination on Standard 90.1, states are statutorily required to certify within two years that they have reviewed and updated the commercial provisions of their building energy code, with respect to energy efficiency, to meet or exceed the revised standard. This report provides a preliminary qualitative analysis of all addenda to ANSI/ASHRAE/IES Standard 90.1-2010 (referred to as Standard 90.1-2010 or 2010 edition) that were included in ANSI/ASHRAE/IES Standard 90.1-2013 (referred to as Standard 90.1-2013 or 2013 edition).

  5. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in the United States. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D.A.; Weaver, C.L.; Gallagher, K.C.; Hejna, D.; Rielley, K.J.

    1980-01-01

    This report is a summary of a series of preliminary reports describing the laws and regulatory programs of the United states and each of the 50 states affecting the siting and operation of energy generating facilities likely to be used in Integrated Community Energy Systems (ICES). A brief summary of public utility regulatory programs, energy facility siting programs, and municipal franchising authority is presented in this report to identify how such programs and authority may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES. Subsequent reports will (1) describe public utility rate regulatory procedures and practices as they might affect an ICES, (2) analyze each of the aforementioned regulatory programs to identify impediments to the development of ICES, and (3) recommend potential changes in legislation and regulatory practices and procedures to overcome such impediments.

  6. Preliminary determination of Newtonian gravitational constant with angular acceleration feedback method.

    Science.gov (United States)

    Xue, Chao; Quan, Li-Di; Yang, Shan-Qing; Wang, Bing-Peng; Wu, Jun-Fei; Shao, Cheng-Gang; Tu, Liang-Cheng; Milyukov, Vadim; Luo, Jun

    2014-10-13

    This paper describes the preliminary measurement of the Newtonian gravitational constant G with the angular acceleration feedback method at HUST. The apparatus has been built, and preliminary measurement performed, to test all aspects of the experimental design, particularly the feedback function, which was recently discussed in detail by Quan et al. The experimental results show that the residual twist angle of the torsion pendulum at the signal frequency introduces 0.4 ppm to the value of G. The relative uncertainty of the angular acceleration of the turntable is approximately 100 ppm, which is mainly limited by the stability of the apparatus. Therefore, the experiment has been modified with three features: (i) the height of the apparatus is reduced almost by half, (ii) the aluminium shelves were replaced with shelves made from ultra-low expansion material and (iii) a perfect compensation of the laboratory-fixed gravitational background will be carried out. With these improvements, the angular acceleration is expected to be determined with an uncertainty of better than 10 ppm, and a reliable value of G with 20 ppm or below will be obtained in the near future.

  7. Preliminary Study of Testosterone and Empathy in Determining Recidivism and Antisocial Behavior.

    Science.gov (United States)

    House, Samuel J; Laan, Jacob M; Molden, Raymond K; Ritchie, James C; Stowe, Zachary N

    2017-02-15

    Recidivism, repeated criminal behavior after conviction and correction of prior offenses, is a costly problem across the nation. However, the contribution of empathy in determining the risk of recidivism has received limited attention, although lack of empathy has been related to antisocial personality disorder in various studies. Studies linked testosterone to aggression, antisocial behavior, and criminality, and evidence support hormonal connections between empathy and aggression. Adult male prison inmates convicted of violent or nonviolent offenses were included in a cross-sectional study of empathy, antisocial behavior, salivary testosterone, and recidivism. Subjects underwent criminal history, Empathy Quotient, Levenson Self-Report Psychopathy Scale, Beck Depression Inventory, Spielberger State-Trait Anxiety Inventory, and salivary testosterone assays. Bivariate analyses indicated multiple correlations between variables. Multivariate modeling analyses found a significant relationship between self-reported conviction number and psychopathy scale score (p = 0.013). These preliminary results suggest avenues of investigation of factors contributing to recidivism risk.

  8. Preliminary result of earthquake hypocenter determination using hypoellipse around western Java region

    Science.gov (United States)

    Supendi, Pepen; Nugraha, Andri Dian

    2016-05-01

    West Java region is located in high seismicity and active tectonic setting region influenced by subducting Indo-Australian plate beneath Eurasia plate. There are several on land active faults namely Cimandiri fault, Lembang fault, and Baribis fault in the region. MCGA earthquake data catalog from 2009 to 2014 shows the earthquakes were located not only around active faults but also relatively far away from the active faults in West Java region. In this study, we determined the earthquake location through re-picking of P-and S-wave arrival times recording by MCGA network. Earthquake location was determined by using Hypoellipse code that employs a single event determination method. We then relocated the events using hypocenter double-difference method. We also have been conducting focal mechanism analysis to estimate the type of fault slip. Our preliminary results show generally the epicenter location were distributed around the on land active fault which have the focus depth less than 30 km. For ongoing and future works, we have been determining focal mechanism of selected event related to on land active fault for this region..

  9. Mapping the nomological network of employee self-determined safety motivation: A preliminary measure in China.

    Science.gov (United States)

    Jiang, Li; Tetrick, Lois E

    2016-09-01

    The present study introduced a preliminary measure of employee safety motivation based on the definition of self-determination theory from Fleming (2012) research and validated the structure of self-determined safety motivation (SDSM) by surveying 375 employees in a Chinese high-risk organization. First, confirmatory factor analysis (CFA) was used to examine the factor structure of SDSM, and indices of five-factor model CFA met the requirements. Second, a nomological network was examined to provide evidence of the construct validity of SDSM. Beyond construct validity, the analysis also produced some interesting results concerning the relationship between leadership antecedents and safety motivation, and between safety motivation and safety behavior. Autonomous motivation was positively related to transformational leadership, negatively related to abusive supervision, and positively related to safety behavior. Controlled motivation with the exception of introjected regulation was negatively related to transformational leadership, positively related to abusive supervision, and negatively related to safety behavior. The unique role of introjected regulation and future research based on self-determination theory were discussed.

  10. 78 FR 12330 - Determination of Regulatory Review Period for Purposes of Patent Extension; SAPIEN TRANSCATHETER...

    Science.gov (United States)

    2013-02-22

    ... and an approval phase. For medical devices, the testing phase begins with a clinical investigation of... length of a regulatory review period for a medical device will include all of the testing phase and... and Trademarks, Department of Commerce, for the extension of a patent which claims that medical...

  11. Preliminary determination of the energy potential of ocean currents along the southern coast of Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, Andrea; Beluco, Alexandre; de Almeida, Luiz Emilio B. [Inst. Pesquisas Hidraulicas, Univ. Fed Rio Grande do Sul, Porto Alegre (Brazil)

    2013-07-01

    The ocean can be a strategic alternative for obtaining energy supplies, both from ocean waves as from sea currents and tides. Among these features, the power generation projects based on ocean currents are still under development. Generating energy from ocean can have great impact on the Brazilian energy grid, since Brazil has a vast coastline, with more than 9,000 km long, with potential for generating energy from ocean currents not fully estimated. This article presents a preliminary determination of the energy potential for power generation from ocean currents along the coast of Rio Grande do Sul, the southernmost state of Brazil, and also presents notes that contribute to the characterization of the system of ocean currents in the region. The data used were obtained in two areas near Tramandai, allowing the determination of velocities and directions of the currents on a seasonal basis. The maximum speeds obtained rarely exceed 0.750 m/s, while the average speeds do not exceed 0.200 m/s. A relationship with the prevailing winds in the region was identified. Unfortunately, the results do not allow optimism about the power generation from ocean currents on the southern coast of Brazil, at least over the continental shelf.

  12. Preliminary study on element mass fraction determination on catfish samples from Paraguay

    Energy Technology Data Exchange (ETDEWEB)

    Moreira, Edson G.; Catharino, Marilia G.M.; Vasconcellos, Marina B.A., E-mail: emoreira@ipen.br, E-mail: mbvascon@ipen.br, E-mail: mariliasemmler@uol.com.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Frutos, Sixto A.; Insaurralde, Mario S., E-mail: tony8013@hotmail.com, E-mail: insaurraldemar9@hotmail.com [Universidad Nacional de Asuncion (FCV/UNA), San Lorenzo (Paraguay). Facultad de Ciencias Veterinarias. Departamento de Pesca y Acuicultura

    2013-07-01

    South American catfish (Pseudoplatystoma), commonly known in Spanish as atigrado or surubi and in Portuguese as surubim or pintado is a large fish that typically reaches 1 m long and weighs 60 kg to 80 kg and may be found at the basins of the Amazon, the Sao Francisco and de la Plata rivers, usually in riverbeds and deep wells. Being a much appreciated fish for human consumption, it is quite sought after by fishermen who have been contributing to the reduction of the stocks. This fact attracted the attention of the Paraguayan authorities to the point of imposing restrictions to free fishing and commercialization. This study aims to assist the conservation efforts towards this fish by investigating its exposure to possible pollutants. Preliminary results on element determination on six samples of catfish from Paraguayan rivers are presented. Cs, Co, Fe, Se and Zn were determined by applying an Instrumental Neutron Activation Analysis method. While these element levels were lower than the legislation for human consumption, the elements As, Cr e La were not detected in the samples as they are below the detection limit of the method employed. Atomic Absorption Spectrometry was used to investigate the presence of Cd, Hg and Pb in the samples. Hg was detected in the samples while Cd and Pb were below the detection limit of the method. (author)

  13. Expression of steroidogenic acute regulatory protein (StAR) in male American bullfrog (Rana catesbeiana) and preliminary evaluation of the response to TNT.

    Science.gov (United States)

    Paden, Norka E; Carr, James A; Kendall, Ronald J; Wages, Mike; Smith, Ernest E

    2010-06-01

    We examined the expression of steroidogenic acute regulatory (StAR) protein mRNA in the American bullfrog (Rana catesbeiana). Primers and probes were designed to obtain a partial sequence of bullfrog StAR cDNA consisting of 349 base pairs. Quantitative PCR analysis of StAR mRNA equivalents was performed in tissues of juvenile and adult bullfrogs. In this study 18S mRNA was used as an internal standard. There were no differences in the expression of 18S RNA among tissues or between age groups. In juvenile males, the rank order for the constitutive levels of StAR was testes>skin>brain>kidneys. In adult males, StAR mRNA equivalent was greatest in testes, followed by kidneys, brain, and skin. In addition, stimulation and induction of testicular StAR by human chorionic gonadotropin significantly increased expression of StAR at 2, 4, and 6h after injection. Preliminary evaluation of 2, 4, 6-trinitrotoluene (TNT) revealed that acute exposure is associated with reduction of StAR mRNA expression. The information provided in this study will be useful for future research on StAR gene expression in amphibian reproductive biology and the development of reproductive biomarkers.

  14. 76 FR 67703 - Certain Steel Wheels From the People's Republic of China: Notice of Preliminary Determination of...

    Science.gov (United States)

    2011-11-02

    ... was likely to be material injury by reason of such sales, the Department must rely on the facts before... preliminary injury determination.\\22\\ \\22\\ See, e.g., Carbon and Alloy Steel Wire Rod From Germany, Mexico... the available evidence in light of the particular facts of each industry when undertaking its analysis...

  15. Assessment of cheiloscopy in sex determination using lysochrome - A preliminary study.

    Science.gov (United States)

    Ramakrishnan, Prabhath; Bahirwani, Shraddha; Valambath, Smruthi

    2015-01-01

    The present study was undertaken with the objective of ascertaining whether latent lip prints generated by persistent lipsticks and developed using lysochrome dyes have the potential of use in sex determination and personal identification. This study included a total of 100 subjects (50 males and 50 females) whose latent lip prints were obtained by applying the persistent lipstick Revlon ColorStay Overtime(®) manufactured by Revlon(®) consumer products corporation, NewYork, USA, and lifting the prints with cellophane sheets. The prints were then developed using lysochrome dyes, and all the samples were blinded and then graded based on defined patterns from the Suzuki and Tsuchihashi classification. No two lip prints were found to be alike. Type I was found to be the most prevalent type. In the female population, Type I (61%) was most prevalent, followed by Type I' (28%), Type II (9%), Type III (2%), Type IV (1%), and Type V (1%); in the male population, Type I (33%) was most prevalent, followed by Type II (23%), Type III (18%), Type IV (14%), Type I' (10%), and Type V (3%). Two examiners were able to determine the correct sexes from the given sample sizes. Their interobserver agreement was assessed using the kappa coefficient for males (κ =0.870) and females (κ = 0.870). Their accuracy was assessed with a confidence interval (CI) of 91.48-99.38. Lysochrome dyes are very efficacious in developing latent lip prints. This preliminary study has conclusively proved that latent lip prints developed with lysochrome dyes hold the potential for use in sex determination and can be maintained in a digital database.

  16. Assessment of cheiloscopy in sex determination using lysochrome - A preliminary study

    Science.gov (United States)

    Ramakrishnan, Prabhath; Bahirwani, Shraddha; Valambath, Smruthi

    2015-01-01

    Introduction: The present study was undertaken with the objective of ascertaining whether latent lip prints generated by persistent lipsticks and developed using lysochrome dyes have the potential of use in sex determination and personal identification. Materials and Methods: This study included a total of 100 subjects (50 males and 50 females) whose latent lip prints were obtained by applying the persistent lipstick Revlon ColorStay Overtime® manufactured by Revlon® consumer products corporation, NewYork, USA, and lifting the prints with cellophane sheets. The prints were then developed using lysochrome dyes, and all the samples were blinded and then graded based on defined patterns from the Suzuki and Tsuchihashi classification. Results: No two lip prints were found to be alike. Type I was found to be the most prevalent type. In the female population, Type I (61%) was most prevalent, followed by Type I’ (28%), Type II (9%), Type III (2%), Type IV (1%), and Type V (1%); in the male population, Type I (33%) was most prevalent, followed by Type II (23%), Type III (18%), Type IV (14%), Type I’ (10%), and Type V (3%). Two examiners were able to determine the correct sexes from the given sample sizes. Their interobserver agreement was assessed using the kappa coefficient for males (κ =0.870) and females (κ = 0.870). Their accuracy was assessed with a confidence interval (CI) of 91.48-99.38. Conclusion: Lysochrome dyes are very efficacious in developing latent lip prints. This preliminary study has conclusively proved that latent lip prints developed with lysochrome dyes hold the potential for use in sex determination and can be maintained in a digital database. PMID:26816459

  17. 77 FR 37378 - Honey From the People's Republic of China: Affirmative Preliminary Determination of Circumvention...

    Science.gov (United States)

    2012-06-21

    ... International Trade Administration Honey From the People's Republic of China: Affirmative Preliminary... of Antidumping Duty Order. SUMMARY: In response to a request from the American Honey Producers Association and the Sioux Honey Association (collectively ``Petitioners''), the Department of...

  18. 78 FR 61958 - San Juan County Historical Society; Notice of Preliminary Determination of A Qualifying Conduit...

    Science.gov (United States)

    2013-10-08

    ... Hydropower Regulatory Efficiency Act of 2013 (HREA). The 11 kW Silverton Mayflower Mill Hydro Project would... Historical Society, P.O. Box 154, Silverton, CO 81433, Phone No. (970) 387-5488. FERC Contact: Robert...

  19. Intraclonal competition limits the fate determination of regulatory T cells in the thymus.

    Science.gov (United States)

    Bautista, Jhoanne L; Lio, Chan-Wang J; Lathrop, Stephanie K; Forbush, Katherine; Liang, Yuqiong; Luo, Jingqin; Rudensky, Alexander Y; Hsieh, Chyi-Song

    2009-06-01

    Because the deletion of self-reactive T cells is incomplete, thymic development of natural Foxp3+CD4+ regulatory T cells (Treg cells) is required for preventing autoimmunity. However, the function of T cell antigen receptor (TCR) specificity in thymic Treg cell development remains controversial. To address this issue, we generated a transgenic line expressing a naturally occurring Treg cell-derived TCR. Unexpectedly, we found that efficient thymic Treg cell development occurred only when the antigen-specific Treg cell precursors were present at low clonal frequency (o1%) in a normal thymus. Using retroviral vectors and bone marrow chimeras, we observed similar activity with two other Treg cell-derived TCRs. Our data demonstrate that thymic Treg cell development is a 'TCR-instructive' process involving a niche that can be saturable at much lower clonal frequencies than is the niche for positive selection.

  20. Determination of the heavy metal binding capacity of aquatic samples using MetPLATE: a preliminary study.

    Science.gov (United States)

    Huang, F; Bitton, G; Kong, I C

    1999-08-30

    MetPLATE, a microbial toxicity test which is specific for heavy metal toxicity, was used to rapidly determine the heavy metal binding capacity (HMBC) of a wide range of surface waters from Florida and Georgia. HMBC determines the impact of physicochemical factors on metal bioavailability and toxicity. The new developed protocol, using MetPLATE as the toxicity assay, showed that HMBC varied from 1.7 to 39.2 for Cd whereas the ranges for Cu and Ag were Hogtown Creek, Gainesville, FL, and from the St John's river in Jacksonville, FL. Both surface waters displayed the highest HMBC during the Fall season. Preliminary examination of the limited data set confirms that HMBC may be influenced by the concentration of dissolved organic carbon (DOC). These preliminary data show that the impact of physical and chemical parameters on the toxicity of metals in aquatic environments can be rapidly assessed using rapid and low-cost microbiotests.

  1. Ethical and regulatory challenges in psychophysiology and neuroscience-based technology for determining behavior.

    Science.gov (United States)

    Shamoo, Adil E

    2010-01-01

    In the past three decades, there has been an explosion in research to understand the mechanisms of brain function. Recent advances in psychophysiology and neuroscience, while still limited, have sparked great interest in developing technologies that could peer into the brain and be used to identify or indicate certain behaviors. The polygraph (lie detector) represents an old technology used for discerning clues to the human brain; functional magnetic resonance imaging (fMRI) represents one of the newest efforts. The use of these technologies in intelligence and counterintelligence in the field without validation represents a major concern about its usefulness. Both research on this new technology and subsequent use on public raise ethical challenges. This article will address the overall ethical issues associated with these new technologies. The report identifies the ethical and cultural challenges in conducting research on these new tools, explores the possibility of using current U.S. regulatory requirements regarding drugs and devices as a model for regulating these new technologies, and suggests approaches for the future.

  2. 78 FR 73838 - Steel Concrete Reinforcing Bar From Turkey: Postponement of Preliminary Determination in the...

    Science.gov (United States)

    2013-12-09

    ... International Trade Administration Steel Concrete Reinforcing Bar From Turkey: Postponement of Preliminary... Department of Commerce (the Department) initiated a countervailing duty investigation on steel concrete... December 16, 2013.\\3\\ \\1\\ See Steel Concrete Reinforcing Bar from Turkey: Initiation of Countervailing Duty...

  3. Preliminary Study on the Determination of ~(235)U and ~(239)Pu Using Delayed Neutron Counting Method

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The preliminary study on the fast measurements of 235U and 239Pu in samples containing 235U, 239Pu and 235U-239Pu mixture using delayed neutron counting method is introduced. All samples were irradiated for 30 s using the 30 kW Miniature Neutron

  4. Sphingoid esters from the molecular distillation of squid oil: A preliminary bioactivity determination.

    Science.gov (United States)

    Saliu, Francesco; Longhin, Eleonora; Salanti, Anika; Degano, Ilaria; Della Pergola, Roberto

    2016-06-15

    A mixture of sphingoid esters was isolated (1.4% w/w) from the molecular distillation of crude squid visceral oil. A preliminary investigation on the bioactivity profile and toxic potential of this residue was carried out by in vitro experiments. No cytotoxicity and a moderate lipase inhibition activity were highlighted.

  5. 78 FR 76815 - Steel Threaded Rod From India: Preliminary Affirmative Countervailing Duty Determination and...

    Science.gov (United States)

    2013-12-19

    ... studs made to American Society for Testing and Materials (``ASTM'') A193 Grade B7, ASTM A193 Grade B7M, ASTM A193 Grade B16, and ASTM A320 Grade L7. Appendix 2 List of Topics Discussed in the Preliminary...

  6. ANSI/ASHRAE/IES Standard 90.1-2013 Preliminary Determination: Quantitative Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Halverson, Mark A.; Rosenberg, Michael I.; Wang, Weimin; Zhang, Jian; Mendon, Vrushali V.; Athalye, Rahul A.; Xie, YuLong; Hart, Reid; Goel, Supriya

    2014-03-01

    This report provides a preliminary quantitative analysis to assess whether buildings constructed according to the requirements of ANSI/ASHRAE/IES Standard 90.1-2013 would result in energy savings compared with buildings constructed to ANSI/ASHRAE/IES Standard 90.1-2010.

  7. 75 FR 10761 - Certain Coated Paper from Indonesia: Preliminary Affirmative Countervailing Duty Determination...

    Science.gov (United States)

    2010-03-09

    ...: Corporate and Spatial Distribution of Forest Resources in Indonesia; Implications of Forest Sustainability... International Trade Administration C-560-824 Certain Coated Paper from Indonesia: Preliminary Affirmative...- quality print graphics using sheet-fed presses (certain coated paper or CCP) in Indonesia. For information...

  8. 78 FR 53752 - City of Sandpoint, Idaho; Notice of Preliminary Determination of a Qualifying Conduit Hydropower...

    Science.gov (United States)

    2013-08-30

    ... Qualifying Conduit Hydropower Facility and Soliciting Comments and Motions To Intervene On August 15, 2013, City of Sandpoint, Idaho filed a notice of intent to construct a qualifying conduit hydropower facility, pursuant to section 30 of the Federal Power Act, as amended by section 4 of the Hydropower Regulatory...

  9. 78 FR 61987 - Corbett Water District; Notice of Preliminary Determination of a Qualifying Conduit Hydropower...

    Science.gov (United States)

    2013-10-09

    ... Conduit Hydropower Facility and Soliciting Comments and Motions To Intervene On September 23, 2013, Corbett Water District filed a notice of intent to construct a qualifying conduit hydropower facility, pursuant to section 30 of the Federal Power Act, as amended by section 4 of the Hydropower Regulatory...

  10. 78 FR 56872 - City of Barre, Vermont; Notice of Preliminary Determination of a Qualifying Conduit Hydropower...

    Science.gov (United States)

    2013-09-16

    ... Conduit Hydropower Facility and Soliciting Comments and Motions To Intervene On August 29, 2013, City of Barre, Vermont filed a notice of intent to construct a qualifying conduit hydropower facility, pursuant to section 30 of the Federal Power Act, as amended by section 4 of the Hydropower Regulatory...

  11. 75 FR 75678 - Determination of Regulatory Review Period for Purposes of Patent Extension; STELARA

    Science.gov (United States)

    2010-12-06

    ... candidates for phototherapy or systemic therapy. Subsequent to this approval, the Patent and Trademark Office... Centocor Ortho Biotech Inc., and the Patent and Trademark Office requested FDA's assistance in determining...

  12. Use of allele-specific FAIRE to determine functional regulatory polymorphism using large-scale genotyping arrays

    DEFF Research Database (Denmark)

    Smith, Frank Andrew; Howard, Philip; Shah, Sonia;

    2012-01-01

    identified an allele-specific regulatory polymorphism within NR1H3 (coding for LXR-α), rs7120118, coinciding with a previously GWAS-identified SNP for HDL-C levels. This finding was confirmed using FAIRE-gen with the 200,000 SNP Illumina Metabochip and verified with the established method of TaqMan allelic...... variants, we describe the technique of allele-specific FAIRE, utilising large-scale genotyping technology (FAIRE-gen) to determine allelic effects on chromatin accessibility and regulatory potential. FAIRE-gen was explored using lymphoblastoid cells and the 50,000 SNP Illumina CVD BeadChip. The technique...... discrimination. Examination of this SNP in two prospective Caucasian cohorts comprising 15,000 individuals confirmed the association with HDL-C levels (combined beta = 0.016; p = 0.0006), and analysis of gene expression identified an allelic association with LXR-α expression in heart tissue. Using increasingly...

  13. Plasticity of gene-regulatory networks controlling sex determination: of masters, slaves, usual suspects, newcomers, and usurpators.

    Science.gov (United States)

    Herpin, Amaury; Schartl, Manfred

    2015-10-01

    Sexual dimorphism is one of the most pervasive and diverse features of animal morphology, physiology, and behavior. Despite the generality of the phenomenon itself, the mechanisms controlling how sex is determined differ considerably among various organismic groups, have evolved repeatedly and independently, and the underlying molecular pathways can change quickly during evolution. Even within closely related groups of organisms for which the development of gonads on the morphological, histological, and cell biological level is undistinguishable, the molecular control and the regulation of the factors involved in sex determination and gonad differentiation can be substantially different. The biological meaning of the high molecular plasticity of an otherwise common developmental program is unknown. While comparative studies suggest that the downstream effectors of sex-determining pathways tend to be more stable than the triggering mechanisms at the top, it is still unclear how conserved the downstream networks are and how all components work together. After many years of stasis, when the molecular basis of sex determination was amenable only in the few classical model organisms (fly, worm, mouse), recently, sex-determining genes from several animal species have been identified and new studies have elucidated some novel regulatory interactions and biological functions of the downstream network, particularly in vertebrates. These data have considerably changed our classical perception of a simple linear developmental cascade that makes the decision for the embryo to develop as male or female, and how it evolves.

  14. Psychological determinants of financial buffer saving : The influence of financial risk tolerance and regulatory focus

    NARCIS (Netherlands)

    Magendans, J.; Gutteling, Jan M.; Zebel, Sven

    With governments redistributing more responsibilities unto citizens, individuals have an increasing need for financial resources acting as a buffer against life’s setbacks and unexpected expenditures. The purpose of this study was to examine psychological determinants of saving for a financial

  15. Psychological determinants of financial buffer saving: The influence of financial risk tolerance and regulatory focus

    NARCIS (Netherlands)

    Magendans, J.; Gutteling, J.M.; Zebel, S.

    2016-01-01

    With governments redistributing more responsibilities unto citizens, individuals have an increasing need for financial resources acting as a buffer against life’s setbacks and unexpected expenditures. The purpose of this study was to examine psychological determinants of saving for a financial buffe

  16. 24 CFR 1710.15 - Regulatory exemption-multiple site subdivision-determination required.

    Science.gov (United States)

    2010-04-01

    ... should be aware of. The following are some of those risks: The future value of land is uncertain and... expense. If the land is not served by a central sewage system and/or water system, you should contact the local authorities to determine whether a permit will be given for an on-site sewage disposal system...

  17. Motivation and career-development training programs: Use of regulatory focus to determine program effectiveness

    OpenAIRE

    Anthony, Peter John; Weide, Jeffrey

    2015-01-01

    Higgins (2005) developed a motivational theory that distinguishes between two foci: preventative and promotion. Individuals with a preventative focus are motivated to complete activities due to a necessity or expectation. However, those with a promotion focus find motivation from advancement, self-improvement, or social impact. Writers typically use Higgins’ theory on workplace teams and psychology, yet the theory has usefulness for determining training program effectiveness (Carter, 2011; Fr...

  18. Fruit fly (Diptera: Tephritidae) host status determination: critical conceptual, methodological, and regulatory considerations.

    Science.gov (United States)

    Aluja, Martín; Mangan, Robert L

    2008-01-01

    Although fruit fly host status determination/designation lies at the heart of strategic decisions on national and international trade of fruit and vegetables, all attempts thus far to define host plant status have been contentious and as a result long-standing disputes between commercial partners throughout the world have lingered over decades. Part of the problem is that too little effort has been devoted to understanding the underlying mechanisms involved in host plant use by fruit flies and that instead economic and political interests usually prevail. Here we review the most important evolutionary, biological, ecological, physiological, and behavioral aspects that drive host use by fruit flies, and then construct a flow diagram rooted in these fundamentals that outlines a series of steps and definitions to determine if a particular fruit or vegetable (and cultivars thereof) is a natural host, or a conditional (potential, artificial) host, or a nonhost. Along the way, we incorporate risk analysis considerations and propose that the underlying complexity determining host plant utilization by fruit flies requires a flexible systems approach capable of realistically dealing with fly/host/environment/geographic variability on a case-by-case basis.

  19. Use of a regulatory mechanism of sex determination in pest insect control

    Indian Academy of Sciences (India)

    Tarig Dafa'alla; Gouliang Fu; Luke Alphey

    2010-09-01

    The sexual development of an insect is defined through a hierarchical control of several sex determining genes. Of these genes, transformer (tra) and doublesex (dsx) are well characterized and functionally conserved, especially dsx. Both genes are regulated at the transcriptional level through sex-specific alternative splicing. Incorporation of a genetically engineered sex-specific splicing module derived from these genes in transgenic systems, such as RIDL (release of insects carrying a dominant lethal), would allow the production of male-only insects for control programmes without any physical intervention.

  20. Preliminary Analysis of Ground-based Orbit Determination Accuracy for the Wide Field Infrared Survey Telescope (WFIRST)

    Science.gov (United States)

    Sease, Brad

    2017-01-01

    The Wide Field Infrared Survey Telescope is a 2.4-meter telescope planned for launch to the Sun-Earth L2 point in 2026. This paper details a preliminary study of the achievable accuracy for WFIRST from ground-based orbit determination routines. The analysis here is divided into two segments. First, a linear covariance analysis of early mission and routine operations provides an estimate of the tracking schedule required to meet mission requirements. Second, a simulated operations scenario gives insight into the expected behavior of a daily Extended Kalman Filter orbit estimate over the first mission year given a variety of potential momentum unloading schemes.

  1. Preliminary results of determination of chemical element concentrations in the aerosol of Venus clouds

    Science.gov (United States)

    Andreychikov, B. M.; Mukhin, L. M.; Korchuganov, B. N.; Akhmetshin, I. K.; Tokarev, Y. N.; Medvedev, A. V.; Goldfeld, M. N.; Faynboym, V. M.; Kalyuzhnyy, A. V.; Petryanov, I. V.

    1986-01-01

    An X-ray radiometeric experiment is described along with the results of measurements of the elemental composition of aerosols in Venusian clouds. A preliminary analysis of the data showed that sulfur is present in the range of heights 63 to 47 km with mean content of 5.8 mg/cu m and that chlorine is present in the height range 61 t0 52 km with a mean content of 4.1 mg/cu m. The results of measurements in the range 52 to 47 km may come to an agreement if phosphorus is present in the aerosol with a mean concentration of 7.7 mg/cu m.

  2. Preliminary identification and analysis of point mutations corre-lated with response to interferon-α in hepatitis B virus post-transcriptional regulatory elements

    Institute of Scientific and Technical Information of China (English)

    XING Tong-jing; LUO Kang-xian; HOU Jin-lin

    2005-01-01

    Background It is still unclear whether viral genetic variability influences response to interferon(IFN)-α treatment. Recent reports suggest that IFN-α effects may be associated with hepatitis B virus(HBV) post-transcriptional regulation. This study was designed to explore the heterogeneity of HBV post-transcriptional regulatory elements (HPRE) and the relationship between the diversity of HPRE and the response to IFN-α treatment. Methods The HPRE sequences from 31 Chinese patients infected with HBV were determined by directly sequencing of polymerase chain reaction (PCR) product, and comparing them to those from Caucasian patients. Subsequently, eukaryotic expression vectors containing HPRE at various points were constructed and transfected into HepG2 cells, which were then exposed to recombinant human cytokines. Results The T to C point mutation at nt 1504 and the C to T (G) at nt 1508 in HPRE were found in 21 and 19 patients with chronic hepatitis B, respectively; the C to T point mutation at nt 1509 was found in 17 patients. These point mutations did not exist in the HPRE of the Caucasian patients. The activity of the CAT gene obviously increased in the case of T to C point mutation at nt 1504, but did not change in the case of the C to T (G) mutations at nt 1508 and 1509. The activity of the CAT gene at these point mutations of HPRE could be inhibited by IFN-α/γ and tumor necrosis factor (TNF)-α except for the point mutations at nt 1508 of HPRE which may escape the suppression role of IFN-α on HPRE. Conclusions There are point mutations between the HPRE of Chinese and Caucasian HBV patients, which might be correlated with response to IFN-α. The variation of HPRE might affect the function of HPRE and influence the regulative function of IFN-α other than that of IFN-γ or TNF-α on HPRE.

  3. Dynamics and control at feedback vertex sets. II: a faithful monitor to determine the diversity of molecular activities in regulatory networks.

    Science.gov (United States)

    Mochizuki, Atsushi; Fiedler, Bernold; Kurosawa, Gen; Saito, Daisuke

    2013-10-21

    Modern biology provides many networks describing regulations between many species of molecules. It is widely believed that the dynamics of molecular activities based on such regulatory networks are the origin of biological functions. However, we currently have a limited understanding of the relationship between the structure of a regulatory network and its dynamics. In this study we develop a new theory to provide an important aspect of dynamics from information of regulatory linkages alone. We show that the "feedback vertex set" (FVS) of a regulatory network is a set of "determining nodes" of the dynamics. The theory is powerful to study real biological systems in practice. It assures that (i) any long-term dynamical behavior of the whole system, such as steady states, periodic oscillations or quasi-periodic oscillations, can be identified by measurements of a subset of molecules in the network, and that (ii) the subset is determined from the regulatory linkage alone. For example, dynamical attractors possibly generated by a signal transduction network with 113 molecules can be identified by measurement of the activity of only 5 molecules, if the information on the network structure is correct. Our theory therefore provides a rational criterion to select key molecules to control a system. We also demonstrate that controlling the dynamics of the FVS is sufficient to switch the dynamics of the whole system from one attractor to others, distinct from the original.

  4. A Preliminary List of Horizontally Transferred Genes in Prokaryotes Determined by Tree Reconstruction and Reconciliation

    Directory of Open Access Journals (Sweden)

    Hyeonsoo Jeong

    2017-08-01

    Full Text Available Genome-wide global detection of genes involved in horizontal gene transfer (HGT remains an active area of research in medical microbiology and evolutionary genomics. Utilizing the explicit evolutionary method of comparing topologies of a total of 154,805 orthologous gene trees against corresponding 16S rRNA “reference” trees, we previously detected a total of 660,894 candidate HGT events in 2,472 completely-sequenced prokaryotic genomes. Here, we report an HGT-index for each individual gene-reference tree pair reconciliation, representing the total number of detected HGT events on the gene tree divided by the total number of genomes (taxa member of that tree. HGT-index is thus a simple measure indicating the sensitivity of prokaryotic genes to participate (or not participate in HGT. Our preliminary list provides HGT-indices for a total of 69,365 genes (detected in >10 and <50% available prokaryotic genomes that are involved in a wide range of biological processes such as metabolism, information, and bacterial response to environment. Identification of horizontally-derived genes is important to combat antibiotic resistance and is a step forward toward reconstructions of improved phylogenies describing the history of life. Our effort is thus expected to benefit ongoing research in the fields of clinical microbiology and evolutionary biology.

  5. Comparative Transcriptome Analysis between Gynoecious and Monoecious Plants Identifies Regulatory Networks Controlling Sex Determination in Jatropha curcas.

    Science.gov (United States)

    Chen, Mao-Sheng; Pan, Bang-Zhen; Fu, Qiantang; Tao, Yan-Bin; Martínez-Herrera, Jorge; Niu, Longjian; Ni, Jun; Dong, Yuling; Zhao, Mei-Li; Xu, Zeng-Fu

    2016-01-01

    Most germplasms of the biofuel plant Jatropha curcas are monoecious. A gynoecious genotype of J. curcas was found, whose male flowers are aborted at early stage of inflorescence development. To investigate the regulatory mechanism of transition from monoecious to gynoecious plants, a comparative transcriptome analysis between gynoecious and monoecious inflorescences were performed. A total of 3,749 genes differentially expressed in two developmental stages of inflorescences were identified. Among them, 32 genes were involved in floral development, and 70 in phytohormone biosynthesis and signaling pathways. Six genes homologous to KNOTTED1-LIKE HOMEOBOX GENE 6 (KNAT6), MYC2, SHI-RELATED SEQUENCE 5 (SRS5), SHORT VEGETATIVE PHASE (SVP), TERMINAL FLOWER 1 (TFL1), and TASSELSEED2 (TS2), which control floral development, were considered as candidate regulators that may be involved in sex differentiation in J. curcas. Abscisic acid, auxin, gibberellin, and jasmonate biosynthesis were lower, whereas cytokinin biosynthesis was higher in gynoecious than that in monoecious inflorescences. Moreover, the exogenous application of gibberellic acid (GA3) promoted perianth development in male flowers and partly prevented pistil development in female flowers to generate neutral flowers in gynoecious inflorescences. The arrest of stamen primordium at early development stage probably causes the abortion of male flowers to generate gynoecious individuals. These results suggest that some floral development genes and phytohormone signaling pathways orchestrate the process of sex determination in J. curcas. Our study provides a basic framework for the regulation networks of sex determination in J. curcas and will be helpful for elucidating the evolution of the plant reproductive system.

  6. IFN regulatory factor 8 is a key constitutive determinant of the morphological and molecular properties of microglia in the CNS.

    Directory of Open Access Journals (Sweden)

    Carsten Minten

    Full Text Available IFN regulatory factor (IRF 8 is a transcription factor that has a key role in the cellular response to IFN-γ and is pivotal in myeloid cell differentiation. Whether IRF8 plays a role in the development and function of microglia, the tissue-resident myeloid cells of the brain, is unknown. Here, we show IRF8 is a constitutively produced nuclear factor in microglia, which suggested that IRF8 might also be a key homeostatic transcriptional determinant of the microglial cell phenotype. In support of this, in mice with a targeted disruption of the IRF8 gene, microglia were increased in number and showed gross alterations in morphology and surface area. In situ analysis of some key myeloid markers revealed that IRF8-deficient microglia had significantly reduced levels of Iba1, but increased levels of CD206 (mannose receptor and F4/80 as well as increased tomato lectin binding. Analysis of microglia ex vivo revealed IRF8-deficient microglia had significantly increased levels of CD45, CD11b and F4/80, but significantly decreased levels of the chemokine receptors CCR2, CCR5 and CX3CR1. The known involvement of some of these molecular markers in membrane dynamics and phagocytosis led us to examine the phagocytic capacity of cultured IRF8-deficient microglia, however, this was found to be similar to wild type microglia. We conclude IRF8 is a constitutively produced nuclear factor in resident microglia of the CNS being a crucial transcriptional determinant of the phenotype of these cells in the healthy brain.

  7. 76 FR 77964 - High Pressure Steel Cylinders From the People's Republic of China: Preliminary Determination of...

    Science.gov (United States)

    2011-12-15

    ...'' or ``affiliated persons'': (A) Members of a family, including brothers and sisters (whether by the... International Trade Administration High Pressure Steel Cylinders From the People's Republic of China... Commerce (``Department'') preliminarily determines that high pressure steel cylinders (``steel cylinders...

  8. 75 FR 69403 - Aluminum Extrusions From the People's Republic of China: Notice of Preliminary Determination of...

    Science.gov (United States)

    2010-11-12

    .... (``Shanghai Canghai''), its Chinese exporter and supplier, submitted a product exclusion request for... Aluminium Industry Engineering Co., Ltd. (``CNYD''), a Chinese exporter of assorted aluminum components... determined that India, the Philippines, Indonesia, Thailand, Ukraine and Peru are countries comparable to...

  9. 75 FR 49891 - Drill Pipe from the People's Republic of China: Notice of Preliminary Affirmative Determination...

    Science.gov (United States)

    2010-08-16

    ... Circumstances Determination: Carbon and Certain Alloy Steel Wire Rod From Germany, 67 FR 55808, 55809 (August 30... drill pipe to the United States during the POI subsequently claimed that their shipments do not, in fact...

  10. Geophysical and Geotechnical Determination of Sand Resources on the Florida Atlantic Continental Shelf: Preliminary Results

    Science.gov (United States)

    Finkl, C. W.; Andrews, J. L.; Suthard, B. C.; Robertson, W.

    2007-12-01

    The State of Florida is committed to maintaining beaches to sustain beach width and protect coastal infrastructure. Nearshore sand resources must be identified and cataloged for potential beach nourishment projects in response to sea-level rise and increased tropical storm activity. Given the vast length of Florida coastline, application of a variety of remote sensing techniques are required for measuring large areas in a short amount of time. The study area encompasses a shelf area of about 2,053,220 ha (20,532 km2) from Miami to the Georgia State line (about 653 km shoreline length) and extends up to 27 km offshore to about the 45 m isobath offshore Jacksonville. The continental shelf along the east coast of the Florida peninsula contains a wide range of seafloor environments that lie above the Florida-Hatteras Slope on the shoreface and inner, middle, and outer shelf floors. This study used Airborne Laser Bathymetry (ALB), 3D digital terrain models based on reformatted NOAA bathymetric data, sidescan sonar, and seismic reflection profiling to map seafloor geomorphological conditions that range from coralline-algal reef systems to drowned karst, submerged paleo shorelines (drowned beach ridge plains), and buried paleo channels. Seatruthing of morphosedimentary features is achieved via jetprobe and vibracore surveys in the study of inter-reefal sand troughs, ebb-tidal deltas, transverse bars, shoals, sand waves, ridges, and banks. Preliminary results, which visualize seafloor topography as color-ramped morphoforms, indicate the presence of sedimentary deposits that may constitute viable sand resources for shore protection in the form of beach renourishment. Use of ALB and reformatted NOAA bathymetric data in the form of 3D terrain models permits classification of submarine landform topologies that was heretofore not possible using isobaths. The combination of multiple remote sensing methods showed the spatial distribution of morphosedimentary features and provided

  11. Determinants of premiums in aerospace mergers and acquisitions: A preliminary analysis

    Science.gov (United States)

    Bryant, John K.

    There is a large body of literature on different aspects of premiums as they relate to mergers and acquisitions. However, there is very little literature that specifically discusses the determinants of premiums in aerospace. Few industries have experienced the prolonged consolidation that the aerospace industry has seen. Today, the industry is dominated by a few large firms, but there is still merger activity continuing especially with second-tier firms attempting to secure their future through growth. This paper examines several determinants as applied to 18 aerospace mergers of publicly held companies and divisions from 1991 through April of 2002.

  12. Isospin mixing of isospin-projected Slater determinants: formalism and preliminary applications

    CERN Document Server

    Rafalski, M; Dobaczewski, J

    2008-01-01

    We report on the development of a new theoretical tool that allows for isospin projection of Slater determinants and we present its first applications. In particular, we determine the isospin mixing in ground states of N=Z nuclei and discuss its dependence on the size of the harmonic-oscillator basis used in the calculations. We also discuss the unphysical contribution to the isospin mixing caused by the spurious isospin-symmetry breaking inherent to the mean-field approach. We show that these contributions may be as large as 30% of the value of the isospin-mixing parameter.

  13. 75 FR 5567 - Certain Woven Electric Blankets From the People's Republic of China: Preliminary Determination of...

    Science.gov (United States)

    2010-02-03

    ... for the specified POI are India, Indonesia, the Philippines, Colombia, Thailand, and Peru. On November... ``Normal Value'' section below. The Department determined that India, the Philippines, Indonesia, Colombia... granted a separate rate to Hung Kuo Electronics (Shenzhen) Company Limited. 2. Wholly Chinese-Owned...

  14. 75 FR 54117 - Building Energy Standards Program: Preliminary Determination Regarding Energy Efficiency...

    Science.gov (United States)

    2010-09-03

    ... energy consumption of buildings built to Standard 90.1-2007, as compared with buildings built to Standard... building energy consumption. Additionally, DOE has preliminarily determined site energy savings are...] [FR Doc No: 2010-22060] DEPARTMENT OF ENERGY [Docket No. EERE-2006-BC-0132] RIN 1904-AC18......

  15. Eating on impulse: Implicit attitudes, self-regulatory resources, and trait self-control as determinants of food consumption.

    Science.gov (United States)

    Wang, Yan; Wang, Lei; Cui, Xianghua; Fang, Yuan; Chen, Qianqiu; Wang, Ya; Qiang, Yao

    2015-12-01

    Self-regulatory resources and trait self-control have been found to moderate the impulse-behavior relationship. The current study investigated whether the interaction of self-regulatory resources and trait self-control moderates the association between implicit attitudes and food consumption. One hundred twenty female participants were randomly assigned to either a depletion condition in which their self-regulatory resources were reduced or a no-depletion condition. Participants' implicit attitudes for chocolate were measured with the Single Category Implicit Association Test and self-report measures of trait self-control were collected. The dependent variable was chocolate consumption in an ostensible taste and rate task. Implicit attitudes predicted chocolate consumption in depleted participants but not in non-depleted participants. However, this predictive power of implicit attitudes on eating in depleted condition disappeared in participants with high trait self-control. Thus, trait self-control and self-regulatory resources interact to moderate the prediction of implicit attitude on eating behavior. Results suggest that high trait self-control buffers the effect of self-regulatory depletion on impulsive eating.

  16. Assessment of cheiloscopy in sex determination using lysochrome - A preliminary study

    OpenAIRE

    Prabhath Ramakrishnan; Shraddha Bahirwani; Smruthi Valambath

    2015-01-01

    Introduction: The present study was undertaken with the objective of ascertaining whether latent lip prints generated by persistent lipsticks and developed using lysochrome dyes have the potential of use in sex determination and personal identification. Materials and Methods: This study included a total of 100 subjects (50 males and 50 females) whose latent lip prints were obtained by applying the persistent lipstick Revlon ColorStay Overtime® manufactured by Revlon® consumer products corpora...

  17. PANDA Software and Its Preliminary Result of Positioning and Orbit Determination

    Institute of Scientific and Technical Information of China (English)

    Liu Jing-nan; Ge Mao-rong

    2003-01-01

    PANDA (Position And Navigation Data Analyst) software is designed for data analysis of different satellite positioning and navigation systems, such as SLR, GPS and the future GALIEO.The software has being developed since 2000 at GPS Research Center of Wuhan University. A brief introduction of the software and its developing progress are given at first, and then the results of static positioning and GPS satellite orbit determination archived with PANDA are presented in this paper.

  18. Preliminary LSF and MTF determination for the stereo camera of the BepiColombo mission

    Science.gov (United States)

    Simioni, Emanuele; Da Deppo, Vania; Naletto, Giampiero; Borrelli, Donato; Dami, Michele; Ficai Veltroni, Iacopo; Tommasi, Leonardo; Cremonese, Gabriele

    2014-08-01

    In the context of a stereo-camera, measuring the image quality allows to define the accuracy of the 3D reconstruction. In fact, depending on the precision of the camera position data, on the kind of reconstruction algorithm, and on the adopted camera model, it determines the vertical accuracy of the reconstructed terrain model. Aim of this work is to describe the results and the method implemented to determine the Line Spread Function (LSF) of the Stereoscopic Channel (STC) of the SIMBIOSYS imaging system for the BepiColombo mission. BepiColombo is the cornerstone mission n.5 of the European Space Agency dedicated to the exploration of the innermost planet of the Solar System, Mercury, and it is expected to be launched in 2016. STC is a double push-frame single-detector camera composed by two identical sub-channels looking at ±21° wrt the nadir direction. STC has been designed so to have many optical elements common to both sub-channels. Also the image focal plane is common to the sub-channels and this permits the use of a single detector for the acquisition of the two images, i.e. one for each viewing direction. Considering the novelty of the design, conceived to sustain a harsh environment and to be as compact as possible, the STC unit is very complex. To obtain the most accurate 3D reconstruction of the Mercury surface, a camera model as precise as possible is needed, and an ad-hoc calibration set-up has been designed to calibrate the instrument both from the usual geometrical and radiometrical points of view and more specifically for the instrument stereo capability. In this context LSF estimation was performed with a new method applying a particular oversampling approach for the curve fitting to determine at first the entire calibration system transfer function and at the end the optical properties of the single instrument.

  19. Preliminary PM2.5 and PM10 fractions source apportionment complemented by statistical accuracy determination

    Directory of Open Access Journals (Sweden)

    Samek Lucyna

    2016-03-01

    Full Text Available Samples of PM10 and PM2.5 fractions were collected between the years 2010 and 2013 at the urban area of Krakow, Poland. Numerous types of air pollution sources are present at the site; these include steel and cement industries, traffic, municipal emission sources and biomass burning. Energy dispersive X-ray fluorescence was used to determine the concentrations of the following elements: Cl, K, Ca, Ti, Mn, Fe, Ni, Cu, Zn, Br, Rb, Sr, As and Pb within the collected samples. Defining the elements as indicators, airborne particulate matter (APM source profiles were prepared by applying principal component analysis (PCA, factor analysis (FA and multiple linear regression (MLR. Four different factors identifying possible air pollution sources for both PM10 and PM2.5 fractions were attributed to municipal emissions, biomass burning, steel industry, traffic, cement and metal industry, Zn and Pb industry and secondary aerosols. The uncertainty associated with each loading was determined by a statistical simulation method that took into account the individual elemental concentrations and their corresponding uncertainties. It will be possible to identify two or more sources of air particulate matter pollution for a single factor in case it is extremely difficult to separate the sources.

  20. [Preliminary Study on Cognitive Determinants Influencing Argentine Youngsters towards Intensive Alcohol Consumption or Binge Drinking].

    Science.gov (United States)

    Gómez, Raúl Ángel; Luque, Leticia Elizabeth; Tomas, María Teresa Cortés; Tort, Begoña Espejo; Giménez, José Antonio

    2012-06-01

    The current alcohol consumption pattern among youngsters and adolescents, characterized by heavy drinking during a few hours, several days a week, or binge drinking (binge drinking, concentrated drinking or long-gulp drinking) is a reality in many countries, including Spain and Argentina. To describe cognitive determinants in the behavior regarding excessive alcohol consumption (binge drinking) in 16-25 year subjects in Argentina. An ad hoc survey was conducted to assess cognitive determinants influencing heavy alcohol consumption, according to I. Ajzen's guidelines. There are significant statistic differences between the group of heavy drinkers and the group that does not reach such level of consumption in relation to behavioral beliefs, and control beliefs. Both groups recognized consumption is noxious and not safe; no differences were observed concerning normative beliefs. There is a complex interaction mong attitudinal factors, motivational and behavior control factors. Instruments require greater sensitivity and further in-depth analysis is required regardomg short, middle and long consequences generated by binge drinking and its role as a positive or negative reinforment. Copyright © 2012 Asociación Colombiana de Psiquiatría. Publicado por Elsevier España. All rights reserved.

  1. Regulatory agencies and regulatory risk

    OpenAIRE

    Knieps, Günter; Weiß, Hans-Jörg

    2007-01-01

    The aim of this paper is to show that regulatory risk is due to the discretionary behaviour of regulatory agencies, caused by a too extensive regulatory mandate provided by the legislator. The normative point of reference and a behavioural model of regulatory agencies based on the positive theory of regulation are presented. Regulatory risk with regard to the future behaviour of regulatory agencies is modelled as the consequence of the ex ante uncertainty about the relative influence of inter...

  2. Determinants of eligibility and use of ehealth for cardiac rehabilitation patients: preliminary results.

    Science.gov (United States)

    Wiggers, Anne-Marieke; Peek, Niels; Kraaijenhagen, Roderik; Jaspers, Monique

    2014-01-01

    To foster implementation of eHealth in care practice, it is important to gain insight into the factors that influence acceptance. The aim of this study was to identify determinants of eligibility and use for completing an electronic needs assessment for cardiac rehabilitation. We analysed the influence of age, gender, diagnosis, health literacy, quality of life scores, and depression and anxiety scores. Among 240 patients entering CR in two clinics, 101 patients were deemed eligible to use the system by their CR professional, of which 75 (74.2%) actually used it. Only 50% of the patients who had an acute coronary syndrome and 20% of the patients with chronic heart failure were deemed eligible. Furthermore, there was a decreasing trend towards usage in female patients, patients with symptoms of anxiety, and patients with a better quality of life. In the future we will continue to explore barriers and success factors as experienced by the patients and the participating clinics to optimize the system.

  3. Expression, purification, crystallization and preliminary X-ray analysis of calmodulin in complex with the regulatory domain of the plasma-membrane Ca2+-ATPase ACA8

    DEFF Research Database (Denmark)

    Tidow, Henning; Hein, Kim Langmach; Bækgaard, Lone

    2010-01-01

    -bound calmodulin (Ca(2+)-CaM) to this tail and a conformational change that displaces the autoinhibitory tail from the catalytic domain. The complex between calmodulin and the regulatory domain of the plasma-membrane Ca(2+)-ATPase ACA8 from Arabidopsis thaliana has been crystallized. The crystals belonged to space......Plasma-membrane Ca(2+)-ATPases (PMCAs) are calcium pumps that expel Ca(2+) from eukaryotic cells to maintain overall Ca(2+) homoeostasis and to provide local control of intracellular Ca(2+) signalling. They are of major physiological importance, with different isoforms being essential, for example...

  4. Expression, purification, crystallization and preliminary X-ray analysis of calmodulin in complex with the regulatory domain of the plasma-membrane Ca2+-ATPase ACA8

    DEFF Research Database (Denmark)

    Tidow, Henning; Hein, Kim Langmach; Palmgren, Michael Broberg

    2010-01-01

    -bound calmodulin (Ca2+-CaM) to this tail and a conformational change that displaces the autoinhibitory tail from the catalytic domain. The complex between calmodulin and the regulatory domain of the plasma-membrane Ca2+-ATPase ACA8 from Arabidopsis thaliana has been crystallized. The crystals belonged to space......Plasma-membrane Ca2+-ATPases (PMCAs) are calcium pumps that expel Ca2+ from eukaryotic cells to maintain overall Ca2+ homoeostasis and to provide local control of intracellular Ca2+ signalling. They are of major physiological importance, with different isoforms being essential, for example...

  5. The presence of B7-H4+ macrophages and CD25+CD4+ and FOXP3+ regulatory T cells in the microenvironment of nasal polyps - a preliminary report.

    Directory of Open Access Journals (Sweden)

    P Strek

    2011-04-01

    Full Text Available The nasal polyp (NP seems to represent the end-stage of longstanding inflammation in patients with chronic rhinosinusitis. The aim of our study has been to evaluate the presence of two regulatory cell populations in the microenvironment of NP: CD4+CD25high Foxp3+ (Treg cells and B7-H4-expressing macrophages. Treg cells are actively able to inhibit T lymphocytes, while the population of B7-H4-expressing macrophages has recently been described as characterized by a regulatory function similar to that of Treg cells. For our study, we evaluated 14 NP tissue samples. The samples were divided into two main groups, eosinophilic (NP and lymphocytic (NP, according to the predominant type of immune cell infiltration. The presence of Treg cells and B7-H4 positive macrophages in the samples was analyzed by FACS. Treg cells and B7-H4-expressing macrophages were identified in all the examined nasal polyps. The percentages of both Treg cells and of B7H4 positive cells found in the eosinophilic nasal polyps were higher than those found in the lymphocytic nasal polyps. Treg cells and B7H4+ macrophage subpopulations were present in the NP microenvironment and the alterations in their percentages were related to a distinct pattern of immune cell infiltration.

  6. EGF Uptake and Degradation Assay to Determine the Effect of HTLV Regulatory Proteins on the ESCRT-Dependent MVB Pathway.

    Science.gov (United States)

    Murphy, Colin; Sheehy, Noreen

    2017-01-01

    The endosomal sorting complex required for transport (ESCRT) pathway plays key roles in multivesicular bodies (MVBs) formation and lysosomal degradation of membrane receptors, viral budding, and midbody abscission during cytokinesis. The epidermal growth factor receptor (EGFR) is regarded as a prototypical cargo of the MVB/ESCRT pathway and following stimulation by epidermal growth factor (EGF) EGFR/EGF complexes are internalized, sorted into MVBs, and degraded by lysosomes or recycled back to the cell membrane. Here, we describe an assay to analyze the effect of human T-cell leukemia (HTLV) regulatory proteins on the functionality of ESCRT-dependent MVB/lysosomal trafficking of EGFR/EGF complexes. This is performed by direct visualization and quantification of the rate of EGF-Alexa595/EGFR internalization and degradation in HeLa cells expressing HTLV regulatory proteins by immunofluorescence and western blot.

  7. Preliminary Crystallographic Studies of the Regulatory Domain of Response Regulator YycF from an Essential Two-Component Signal Transduction System

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, H.; Heroux, A; Sequeira, R; Tang, L

    2009-01-01

    YycGF is a crucial signal transduction system for the regulation of cell-wall metabolism in low-G+C Gram-positive bacteria, which include many important human pathogens. The response regulator YycF receives signals from its cognate histidine kinase YycG through a phosphotransfer reaction and elicits responses through regulation of gene expression. The N-terminal regulatory domain of YycF from Bacillus subtilis was overproduced and purified. The protein was crystallized and X-ray data were collected to 1.95 A resolution with a completeness of 97.7% and an overall Rmerge of 7.7%. The crystals belonged to space group P3121, with unit-cell parameters a = b = 59.50, c = 79.06 A.

  8. CodY orchestrates the expression of virulence determinants in emetic Bacillus cereus by impacting key regulatory circuits.

    Science.gov (United States)

    Frenzel, Elrike; Doll, Viktoria; Pauthner, Matthias; Lücking, Genia; Scherer, Siegfried; Ehling-Schulz, Monika

    2012-07-01

    Bacillus cereus causes gastrointestinal diseases and local and systemic infections elicited by the depsipeptide cereulide, enterotoxins, phospholipases, cytolysins and proteases. The PlcR-PapR quorum sensing system activates the expression of several virulence factors, whereas the Spo0A-AbrB regulatory circuit partially controls the plasmid-borne cereulide synthetase (ces) operon. Here, we show that CodY, a nutrient-responsive regulator of Gram-positive bacteria, has a profound effect on both regulatory systems, which have been assumed to operate independently of each other. Deletion of codY resulted in downregulation of virulence genes belonging to the PlcR regulon and a concomitant upregulation of the ces genes. CodY was found to be a repressor of the ces operon, but did not interact with the promoter regions of PlcR-dependent virulence genes in vitro, suggesting an indirect regulation of the latter. Furthermore, CodY binds to the promoter of the immune inhibitor metalloprotease InhA1, demonstrating that CodY directly links B. cereus metabolism to virulence. In vivo studies using a Galleria mellonella infection model, showed that the codY mutant was substantially attenuated, highlighting the importance of CodY as a key regulator of pathogenicity. Our results demonstrate that CodY profoundly modulates the virulence of B. cereus, possibly controlling the development of pathogenic traits in suitable host environments.

  9. A trans-acting Variant within the Transcription Factor RIM101 Interacts with Genetic Background to Determine its Regulatory Capacity.

    Science.gov (United States)

    Read, Timothy; Richmond, Phillip A; Dowell, Robin D

    2016-01-01

    Most genetic variants associated with disease occur within regulatory regions of the genome, underscoring the importance of defining the mechanisms underlying differences in regulation of gene expression between individuals. We discovered a pair of co-regulated, divergently oriented transcripts, AQY2 and ncFRE6, that are expressed in one strain of Saccharomyces cerevisiae, ∑1278b, but not in another, S288c. By combining classical genetics techniques with high-throughput sequencing, we identified a trans-acting single nucleotide polymorphism within the transcription factor RIM101 that causes the background-dependent expression of both transcripts. Subsequent RNA-seq experiments revealed that RIM101 regulates many more targets in S288c than in ∑1278b and that deletion of RIM101 in both backgrounds abrogates the majority of differential expression between the strains. Strikingly, only three transcripts undergo a significant change in expression after swapping RIM101 alleles between backgrounds, implying that the differences in the RIM101 allele lead to a remarkably focused transcriptional response. However, hundreds of RIM101-dependent targets undergo a subtle but consistent shift in expression in the S288c RIM101-swapped strain, but not its ∑1278b counterpart. We conclude that ∑1278b may harbor a variant(s) that buffers against widespread transcriptional dysregulation upon introduction of a non-native RIM101 allele, emphasizing the importance of accounting for genetic background when assessing the impact of a regulatory variant.

  10. Preliminary results of the U.S. Nuclear Regulatory Commission collaborative research program to assess tsunami hazard for nuclear power plants on the Atlantic and gulf coasts

    Science.gov (United States)

    Kammerer, A.M.; ten Brink, Uri S.; Twitchell, David C.; Geist, Eric L.; Chaytor, Jason D.; Locat, J.; Lee, H.J.; Buczkowski, Brian J.; Sansoucy, M.

    2018-01-01

    In response to the 2004 Indian Ocean Tsunami, the United States Nuclear Regulatory Commission (US NRC) initiated a long-term research program to improve understanding of tsunami hazard levels for nuclear facilities in the United States. For this effort, the US NRC organized a collaborative research program with the United States Geological Survey (USGS) and other key researchers for the purpose of assessing tsunami hazard on the Atlantic and Gulf Coasts of the United States. The initial phase of this work consisted principally of collection, interpretation, and analysis of available offshore data and information. Necessarily, the US NRC research program includes both seismic- and landslide-based tsunamigenic sources in both the near and the far fields. The inclusion of tsunamigenic landslides, an important category of sources that impact tsunami hazard levels for the Atlantic and Gulf Coasts over the long time periods of interest to the US NRC is a key difference between this program and most other tsunami hazard assessment programs. Although only a few years old, this program is already producing results that both support current US NRC activities and look toward the long-term goal of probabilistic tsunami hazard assessment. This paper provides a summary of results from several areas of current research. An overview of the broader US NRC research program is provided in a companion paper in this conference.

  11. Charts for Determining Preliminary Values of Span-load, Shear, Bending-moment, and Accumulated-torque Distributions of Swept Wings of Various Taper Ratios

    Science.gov (United States)

    Wollner, Bertram C

    1948-01-01

    Contains charts for use in determining preliminary values of the spanwise-load, shear, bending-moment, and accumulated-torque distributions of swept wings. The charts are based on strip theory and include four aerodynamic-load distributions, two section-moment distributions, and two inertia-load distributions. The taper ratios considered cover the range from 1.0 to 0 and the results are applicable to any angle of sweep.

  12. 78 FR 75547 - Prestressed Concrete Steel Rail Tie Wire From Thailand: Preliminary Determination of Sales at Not...

    Science.gov (United States)

    2013-12-12

    ... International Trade Administration Prestressed Concrete Steel Rail Tie Wire From Thailand: Preliminary... concrete steel rail tire wire (``PC tie wire'') from Thailand is not being, or likely to be, sold in the... prestressed tendons in concrete railroad ties (``PC tie wire''). High carbon steel is defined as steel that...

  13. 78 FR 79670 - Steel Threaded Rod From Thailand: Preliminary Determination of Sales at Less Than Fair Value and...

    Science.gov (United States)

    2013-12-31

    ... studs made to American Society for Testing and Materials (``ASTM'') A193 Grade B7, ASTM A193 Grade B7M, ASTM A193 Grade B16, and ASTM A320 Grade L7. Appendix II List of Topics Discussed in the Preliminary...

  14. Development and preliminary validation of the 'Caring for Country' questionnaire: measurement of an Indigenous Australian health determinant

    Directory of Open Access Journals (Sweden)

    Gunthorpe Wendy

    2008-12-01

    Full Text Available Abstract Background 'Caring for Country' is defined as Indigenous participation in interrelated activities with the objective of promoting ecological and human health. Ecological services on Indigenous-owned lands are belatedly attracting some institutional investment. However, the health outcomes associated with Indigenous participation in 'caring for country' activities have never been investigated. The aims of this study were to pilot and validate a questionnaire measuring caring for country as an Indigenous health determinant and to relate it to an external reference, obesity. Methods Purposively sampled participants were 301 Indigenous adults aged 15 to 54 years, recruited during a cross-sectional program of preventive health checks in a remote Australian community. Questionnaire validation was undertaken with psychometric tests of internal consistency, reliability, exploratory factor analysis and confirmatory one-factor congeneric modelling. Accurate item weightings were derived from the model and used to create a single weighted composite score for caring for country. Multiple linear regression modelling was used to test associations between the caring for country score and body mass index adjusting for socio-demographic factors and health behaviours. Results The questionnaire demonstrated adequate internal consistency, test-retest validity and proxy-respondent validity. Exploratory factor analysis of the 'caring for country' items produced a single factor solution that was confirmed via one-factor congeneric modelling. A significant and substantial association between greater participation in caring for country activities and lower body mass index was demonstrated. Adjusting for socio-demographic factors and health behaviours, an inter-quartile range rise in caring for country scores was associated with 6.1 Kg and 5.3 Kg less body weight for non-pregnant women and men respectively. Conclusion This study indicates preliminary support for

  15. Interferon regulatory factor 8-deficiency determines massive neutrophil recruitment but T cell defect in fast growing granulomas during tuberculosis.

    Directory of Open Access Journals (Sweden)

    Stefano Rocca

    Full Text Available Following Mycobacterium tuberculosis (Mtb infection, immune cell recruitment in lungs is pivotal in establishing protective immunity through granuloma formation and neogenesis of lymphoid structures (LS. Interferon regulatory factor-8 (IRF-8 plays an important role in host defense against Mtb, although the mechanisms driving anti-mycobacterial immunity remain unclear. In this study, IRF-8 deficient mice (IRF-8⁻/⁻ were aerogenously infected with a low-dose Mtb Erdman virulent strain and the course of infection was compared with that induced in wild-type (WT-B6 counterparts. Tuberculosis (TB progression was examined in both groups using pathological, microbiological and immunological parameters. Following Mtb exposure, the bacterial load in lungs and spleens progressed comparably in the two groups for two weeks, after which IRF-8⁻/⁻ mice developed a fatal acute TB whereas in WT-B6 the disease reached a chronic stage. In lungs of IRF-8⁻/⁻, uncontrolled growth of pulmonary granulomas and impaired development of LS were observed, associated with unbalanced homeostatic chemokines, progressive loss of infiltrating T lymphocytes and massive prevalence of neutrophils at late infection stages. Our data define IRF-8 as an essential factor for the maintenance of proper immune cell recruitment in granulomas and LS required to restrain Mtb infection. Moreover, IRF-8⁻/⁻ mice, relying on a common human and mouse genetic mutation linked to susceptibility/severity of mycobacterial diseases, represent a valuable model of acute TB for comparative studies with chronically-infected congenic WT-B6 for dissecting protective and pathological immune reactions.

  16. Interferon regulatory factor 8-deficiency determines massive neutrophil recruitment but T cell defect in fast growing granulomas during tuberculosis.

    Science.gov (United States)

    Rocca, Stefano; Schiavoni, Giovanna; Sali, Michela; Anfossi, Antonio Giovanni; Abalsamo, Laura; Palucci, Ivana; Mattei, Fabrizio; Sanchez, Massimo; Giagu, Anna; Antuofermo, Elisabetta; Fadda, Giovanni; Belardelli, Filippo; Delogu, Giovanni; Gabriele, Lucia

    2013-01-01

    Following Mycobacterium tuberculosis (Mtb) infection, immune cell recruitment in lungs is pivotal in establishing protective immunity through granuloma formation and neogenesis of lymphoid structures (LS). Interferon regulatory factor-8 (IRF-8) plays an important role in host defense against Mtb, although the mechanisms driving anti-mycobacterial immunity remain unclear. In this study, IRF-8 deficient mice (IRF-8⁻/⁻) were aerogenously infected with a low-dose Mtb Erdman virulent strain and the course of infection was compared with that induced in wild-type (WT-B6) counterparts. Tuberculosis (TB) progression was examined in both groups using pathological, microbiological and immunological parameters. Following Mtb exposure, the bacterial load in lungs and spleens progressed comparably in the two groups for two weeks, after which IRF-8⁻/⁻ mice developed a fatal acute TB whereas in WT-B6 the disease reached a chronic stage. In lungs of IRF-8⁻/⁻, uncontrolled growth of pulmonary granulomas and impaired development of LS were observed, associated with unbalanced homeostatic chemokines, progressive loss of infiltrating T lymphocytes and massive prevalence of neutrophils at late infection stages. Our data define IRF-8 as an essential factor for the maintenance of proper immune cell recruitment in granulomas and LS required to restrain Mtb infection. Moreover, IRF-8⁻/⁻ mice, relying on a common human and mouse genetic mutation linked to susceptibility/severity of mycobacterial diseases, represent a valuable model of acute TB for comparative studies with chronically-infected congenic WT-B6 for dissecting protective and pathological immune reactions.

  17. Integration of in silico approaches to determination of endocrine-disrupting perfluorinated chemicals binding potency with steroidogenic acute regulatory protein.

    Science.gov (United States)

    Kranthi Kumar, K; Uma Devi, B; Neeraja, P

    2017-09-30

    A myriad of perfluorinated compounds (PFCs) have the ability to interfere with steroidogenic acute regulatory (StAR) protein. Consequently, PFCs breaches cholesterol biotransformation in mitochondria and cause fatal consequences in steroidogenesis, however, these were poorly characterized. In the present study, we have evaluated toxic potencies, nuclear mediated probabilities and interaction profiles with StAR of PFCs using computational system biology tools. Toxicity endpoints revealed that PFCs contain high carcinogenicity, developmental toxicity, skin sensitization effects with low mutagenic activity. Consensus qualitative nuclear receptor agonist models show higher probability rates towards ER and PPAR-γ receptor than AR and AhR models were observed. To poise the subtle fluctuations of actual predictions, balanced accuracy and MCC were computed, and they signify perfect correlation ranges in all models. Screening studies resulting protein-ligand interaction profiles showed that residues Asn148, Asn150, Glu169, Ala171, Arg182, Phe184, Arg188, Trp241, Thr263 and Phe267 were identified as novel hotspots, participated in halogen bonds, H-bonds, atomic π-stacking, π-cation interactions and salt-bridges formation. Thus, the additional bonds contribute conformer stability that holds the protein structure at flexible state, so that PFCs acts as a barrier to cholesterol binding. From docking outcomes, representation space was created, that specifies high and medium StAR binders were occupied in toxic endpoints space with active concern. PFCs restrain molecular features and mitochondrial membrane disruption functions were revealed by efficient toxicogenomics studies. These data indicate toxicity and StAR protein binding levels of PFCs, sorted pinpoints could be useful in a promising way to know the other environmental pollutants and health risks. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. 75 FR 34749 - Determination of Regulatory Review Period for Purposes of Patent Extension; BYSTOLIC; U.S. Patent...

    Science.gov (United States)

    2010-06-18

    ... Patent Extension; BYSTOLIC; U.S. Patent Nos. 5,759,580 and 6,545,040 AGENCY: Food and Drug Administration... has made the determination because of the submission of applications to the Director of Patents and Trademarks, Department of Commerce, for the extension of a patent which claims that human drug...

  19. Determinants and valuation implications of compulsory stock option disclosures in a weak regulatory setting the case of France

    NARCIS (Netherlands)

    Goh, Lisa; Joos, Philip; Soonawalla, Kazbi

    2016-01-01

    Using a sample of listed French firms in 2005, the year of mandatory IFRS adoption in the European Union (EU), we investigate the determinants of disclosure compliance of stock option expenses under IFRS 2, Share-based Payment. Stock options are a popular means of executive compensation in France re

  20. Determinants and valuation implications of compulsory stock option disclosures in a weak regulatory setting the case of France

    NARCIS (Netherlands)

    Goh, Lisa; Joos, Philip; Soonawalla, Kazbi

    Using a sample of listed French firms in 2005, the year of mandatory IFRS adoption in the European Union (EU), we investigate the determinants of disclosure compliance of stock option expenses under IFRS 2, Share-based Payment. Stock options are a popular means of executive compensation in France

  1. Haplotype determination of the upstream regulatory region and the second exon of the BoLA-DRB3 gene in Holstein cattle.

    Science.gov (United States)

    Goszczynski, D E; Ripoli, M V; Takeshima, S-N; Baltian, L; Aida, Y; Giovambattista, G

    2014-03-01

    Polymorphisms of the BoLA-DRB3 gene are located primarily in the second exon [antigen binding site (ABS)] and, to a lesser extent, in the upstream regulatory region (URR). It can be hypothesised that exon 2 and the URR are under different types of natural selection. The aim of this work was to determine the URR-exon 2 haplotypes; 34 Holstein samples were genotyped by direct sequencing. A total of 7 URR alleles and 23 exon 2 alleles were detected, and 3 of the URR alleles were novel. Our results may suggest that no relationship exists between the URR and exon 2 of the BoLA-DRB3 gene (linkage disequilibrium P value > 0.05), most likely due to recombination over time. Our results also suggest that both regions of class II genes may be included in the development of new genotyping methods based on next-generation DNA sequencing technologies.

  2. Report to the Nuclear Regulatory Commission from the staff panel on the Commission's determination of an Extraordinary Nuclear Occurrence (ENO)

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-01-01

    The Panel finds that the first criterion, pertaining to whether the accident caused a discharge of radioactive material or levels of radiation offsite as defined in 10 CFR 140.84, has not been met. It further finds that there is presently insufficient information to support any definitive finding as to whether or not the second criterion, relating to damage to persons or property offsite as defined in 10 CFR 140.85, has been met. Since the Panel has not found that both criteria have been met, it recommends that the Commission determine that the accident at Three Mile Island did not constitute an extraordinary nuclear occurrence.

  3. A novel method for the simultaneous determination of 14 sweeteners of regulatory interest using UHPLC-MS/MS.

    Science.gov (United States)

    Shah, Romina; Farris, Samantha; De Jager, Lowri S; Begley, Timothy H

    2015-01-01

    An improved, efficient, sensitive method for the determination of 14 non-nutritive sweeteners in food products was developed using electrospray ionisation (ESI) ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) in the negative-ion mode. Fourteen sweeteners and three internal standards were separated on a reversed-phase UHPLC column using a simple gradient programme. Analyte quantitation and confirmation were performed with data collection in multiple reaction monitoring (MRM) mode. Limits of detection (LODs) were determined in a representative drink, candy and yogurt sample and ranged from 0.1 to 1.8 ng ml(-1) (drinks) and from 0.1 to 2.5 ng g(-1) (candy and yogurt). Repeatability at the limit of quantitation (LOQ) ranged from 1% to 13% relative standard deviation (RSD). Twenty-seven commercially available food products were tested using the optimised method showing that the majority of products contained sweetener concentrations below their assigned maximum usable dose. Recovery studies were performed and accuracy data are presented.

  4. Evaluation of the benchmark dose for point of departure determination for a variety of chemical classes in applied regulatory settings.

    Science.gov (United States)

    Izadi, Hoda; Grundy, Jean E; Bose, Ranjan

    2012-05-01

    Repeated-dose studies received by the New Substances Assessment and Control Bureau (NSACB) of Health Canada are used to provide hazard information toward risk calculation. These studies provide a point of departure (POD), traditionally the NOAEL or LOAEL, which is used to extrapolate the quantity of substance above which adverse effects can be expected in humans. This project explored the use of benchmark dose (BMD) modeling as an alternative to this approach for studies with few dose groups. Continuous data from oral repeated-dose studies for chemicals previously assessed by NSACB were reanalyzed using U.S. EPA benchmark dose software (BMDS) to determine the BMD and BMD 95% lower confidence limit (BMDL(05) ) for each endpoint critical to NOAEL or LOAEL determination for each chemical. Endpoint-specific benchmark dose-response levels , indicative of adversity, were consistently applied. An overall BMD and BMDL(05) were calculated for each chemical using the geometric mean. The POD obtained from benchmark analysis was then compared with the traditional toxicity thresholds originally used for risk assessment. The BMD and BMDL(05) generally were higher than the NOAEL, but lower than the LOAEL. BMDL(05) was generally constant at 57% of the BMD. Benchmark provided a clear advantage in health risk assessment when a LOAEL was the only POD identified, or when dose groups were widely distributed. Although the benchmark method cannot always be applied, in the selected studies with few dose groups it provided a more accurate estimate of the real no-adverse-effect level of a substance.

  5. Scientific and Regulatory Policy Committee: Recommended ("Best") Practices for Determining, Communicating, and Using Adverse Effect Data from Nonclinical Studies.

    Science.gov (United States)

    Kerlin, Roy; Bolon, Brad; Burkhardt, John; Francke, Sabine; Greaves, Peter; Meador, Vince; Popp, James

    2016-02-01

    Recommendations (best practices) are provided by the Society of Toxicologic Pathology's Adversity Working Group for making consistent interpretations of test article-related effects as "adverse" and assigning a "no observed adverse effect level" (NOAEL) in nonclinical toxicity studies. Adverse is a term indicating "harm" to the test animal, while nonadverse indicates lack of harm. Adverse findings in the study reports should be defined in relation to effects on the test species used and within the context of the given study. Test article-related effects should be described on their own merits, and decisions to consider them as adverse or nonadverse should be justified. Related effects may be discussed together; in particular, markers of toxicity that are not in and of themselves adverse ideally should be discussed in conjunction with the causal toxicity to determine adversity. Adverse findings should be identified in subreports (clinical data, pathology data, etc.) if sufficient information is available, and/or in the final study report as individual or grouped findings, but study NOAELs should be established at the level of the overall study report. Interpretations such as "not biologically relevant" or "not toxicologically important" should be avoided unless defined and supported by scientific rationale. Decisions defining adverse findings and the NOAEL in final study reports should combine the expertise of all contributing scientific disciplines. Where possible, use of NOAELs in data tables should be linked to explanatory text that places them in context. Ideally, in nonclinical summary documents, NOAELs from multiple studies are considered together in defining the most important adverse responses in the most sensitive species. These responses are then considered along with an understanding of their likely mechanisms, as well as other information such as variability in species sensitivity, comparative pathology, reversibility and progression, kinetics, and

  6. The OsmiR396c-OsGRF4-OsGIF1 regulatory module determines grain size and yield in rice.

    Science.gov (United States)

    Li, Shuangcheng; Gao, Fengyan; Xie, Kailong; Zeng, Xiuhong; Cao, Ye; Zeng, Jing; He, Zhongshan; Ren, Yun; Li, Wenbo; Deng, Qiming; Wang, Shiquan; Zheng, Aiping; Zhu, Jun; Liu, Huainian; Wang, Lingxia; Li, Ping

    2016-11-01

    Grain weight is the most important component of rice yield and is mainly determined by grain size, which is generally controlled by quantitative trait loci (QTLs). Although numerous QTLs that regulate grain weight have been identified, the genetic network that controls grain size remains unclear. Herein, we report the cloning and functional analysis of a dominant QTL, grain length and width 2 (GLW2), which positively regulates grain weight by simultaneously increasing grain length and width. The GLW2 locus encodes OsGRF4 (growth-regulating factor 4) and is regulated by the microRNA miR396c in vivo. The mutation in OsGRF4 perturbs the OsmiR396 target regulation of OsGRF4, generating a larger grain size and enhanced grain yield. We also demonstrate that OsGIF1 (GRF-interacting factors 1) directly interacts with OsGRF4, and increasing its expression improves grain size. Our results suggest that the miR396c-OsGRF4-OsGIF1 regulatory module plays an important role in grain size determination and holds implications for rice yield improvement. © 2016 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.

  7. 18 CFR 1b.6 - Preliminary investigations.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Preliminary investigations. 1b.6 Section 1b.6 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.6 Preliminary investigations....

  8. Sterol regulatory element-binding protein-1 determines plasma remnant lipoproteins and accelerates atherosclerosis in low-density lipoprotein receptor-deficient mice.

    Science.gov (United States)

    Karasawa, Tadayoshi; Takahashi, Akimitsu; Saito, Ryo; Sekiya, Motohiro; Igarashi, Masaki; Iwasaki, Hitoshi; Miyahara, Shoko; Koyasu, Saori; Nakagawa, Yoshimi; Ishii, Kiyoaki; Matsuzaka, Takashi; Kobayashi, Kazuto; Yahagi, Naoya; Takekoshi, Kazuhiro; Sone, Hirohito; Yatoh, Shigeru; Suzuki, Hiroaki; Yamada, Nobuhiro; Shimano, Hitoshi

    2011-08-01

    Sterol regulatory element-binding protein-1 (SREBP-1) is nutritionally regulated and is known to be a key transcription factor regulating lipogenic enzymes. The goal of this study was to evaluate the roles of SREBP-1 in dyslipidemia and atherosclerosis. Transgenic mice that overexpress SREBP-1c in the liver and SREBP-1-deficient mice were crossed with low-density lipoprotein receptor (LDLR)-deficient mice, and the plasma lipids and atherosclerosis were analyzed. Hepatic SREBP-1c overexpression in LDLR-deficient mice caused postprandial hypertriglyceridemia, increased very-low-density lipoprotein (VLDL) cholesterol, and decreased high-density lipoprotein cholesterol in plasma, which resulted in accelerated aortic atheroma formation. Conversely, absence of SREBP-1 suppressed Western diet-induced hyperlipidemia in LDLR-deficient mice and ameliorated atherosclerosis. In contrast, bone marrow-specific SREBP-1 deficiency did not alter the development of atherosclerosis. The size of nascent VLDL particles secreted from the liver was increased in SREBP-1c transgenic mice and reduced in SREBP-1-deficient mice, accompanied by upregulation and downregulation of phospholipid transfer protein expression, respectively. Hepatic SREBP-1c determines plasma triglycerides and remnant cholesterol and contributes to atherosclerosis in hyperlipidemic states. Hepatic SREBP-1c also regulates the size of nascent VLDL particles.

  9. The cellular distribution of Na+/H+ exchanger regulatory factor 1 is determined by the PDZ-I domain and regulates the malignant progression of breast cancer

    Science.gov (United States)

    Du, Guifang; Gu, Yanan; Hao, Chengcheng; Yuan, Zhu; He, Junqi; Jiang, Wen G.; Cheng, Shan

    2016-01-01

    The oncogenic role of ectopic expression of Na+/H+ exchanger regulatory factor 1 (NHERF1) was recently suggested. Here, we show that NHERF1 was upregulated in high grades compared with low grades. Increased NHERF1 expression was correlated with poor prognosis and poor survival. NHERF1 expression was higher in the nucleus of cancer cells than in contiguous non- mammary epithelial cells. A novel mutation, namely NHERF1 Y24S, was identified in human breast cancer tissues and shown to correspond to a conserved residue in the PDZ-I domain of NHERF1. Truncation and mutation of the PDZ-I domain of NHERF1 increased the nuclear distribution of the NHERF1 protein, and this redistribution was associated with the malignant phenotype of breast cancer cells, including growth, migration, and adhesion. The present results suggest a role for NHERF1 in the progression of breast cancer mediated by the nuclear distribution of the NHERF1 protein, as determined by the truncation or key site mutation of the PDZ-I domain. PMID:27097111

  10. Regulatory Anatomy

    DEFF Research Database (Denmark)

    Hoeyer, Klaus

    2015-01-01

    This article proposes the term “safety logics” to understand attempts within the European Union (EU) to harmonize member state legislation to ensure a safe and stable supply of human biological material for transplants and transfusions. With safety logics, I refer to assemblages of discourses, le...... they arise. In short, I expose the regulatory anatomy of the policy landscape....

  11. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in Oregon. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D A; Weaver, C L; Gallagher, K C; Hejna, D; Rielley, K J

    1980-01-01

    The authority to regulate public utilities is vested generally in the Public Utility Commissioner of Oregon. The Commissioner is appointed by the governor, subject to confirmation by the senate, for a term of four years. He must be free of any pecuniary or employment interest in any business subject to the jurisdiction of the Commissioner. While the Commissioner is primarily responsible for regulating public utilities, local governments do retain some control over utility operations within municipal boundaries. A local government may determine by contract or prescribe by ordinance the quality and character of service furnished by a public utility and may control the use of streets and other public property by public utilities. Municipalities may require public utilities to make any modifications, additions, or extensions to facilities as are necessary to the public interest. In addition, local governments may fix, by contract or ordinance, the rates to be charged by public utilities furnishing service within a municipality. The Commissioner, however, has the power to review any of the above-described local actions. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  12. Real-time precise orbit determination of LEO satellites using a single-frequency GPS receiver: Preliminary results of Chinese SJ-9A satellite

    Science.gov (United States)

    Sun, Xiucong; Han, Chao; Chen, Pei

    2017-10-01

    Spaceborne Global Positioning System (GPS) receivers are widely used for orbit determination of low-Earth-orbiting (LEO) satellites. With the improvement of measurement accuracy, single-frequency receivers are recently considered for low-cost small satellite missions. In this paper, a Schmidt-Kalman filter which processes single-frequency GPS measurements and broadcast ephemerides is proposed for real-time precise orbit determination of LEO satellites. The C/A code and L1 phase are linearly combined to eliminate the first-order ionospheric effects. Systematic errors due to ionospheric delay residual, group delay variation, phase center variation, and broadcast ephemeris errors, are lumped together into a noise term, which is modeled as a first-order Gauss-Markov process. In order to reduce computational complexity, the colored noise is considered rather than estimated in the orbit determination process. This ensures that the covariance matrix accurately represents the distribution of estimation errors without increasing the dimension of the state vector. The orbit determination algorithm is tested with actual flight data from the single-frequency GPS receiver onboard China's small satellite Shi Jian-9A (SJ-9A). Preliminary results using a 7-h data arc on October 25, 2012 show that the Schmidt-Kalman filter performs better than the standard Kalman filter in terms of accuracy.

  13. A Preliminary Validation Study of the Korean Version of the Minnesota Self-Determination Scales for Adults With Intellectual Disabilities

    Directory of Open Access Journals (Sweden)

    Jaehyun Cho

    2014-01-01

    Full Text Available The Minnesota Self-Determination Scale (MSDS was translated into Korean. The Korean version was then validated using a sample of 40 individuals with intellectual disabilities between the ages of 19 and 45 years, the legal age of adults in South Korea. The evidence of the reliability and validity was examined. The test–retest was good (.84-.94. The internal consistency was excellent (.96-.99. The construct validity with other Korean translated self-determination measure (K-SDS was acceptable (.50-.51. The findings indicated that the K-MSDS was an appropriate measure with acceptable psychometric properties. The Korean version was the first self-determination measure for adults with disabilities.

  14. 76 FR 68407 - Galvanized Steel Wire From the People's Republic of China: Preliminary Determination of Sales at...

    Science.gov (United States)

    2011-11-04

    ... exporters and producers may obtain separate-rate status in non- market economy (``NME'') investigations.\\3... June 20, 2011, the Department determined that Colombia, Indonesia, the Philippines, South Africa... this notice, below. Non-Market-Economy Country For purposes of initiation, Petitioners submitted LTFV...

  15. 77 FR 46034 - Utility Scale Wind Towers From the People's Republic of China: Preliminary Determination of Sales...

    Science.gov (United States)

    2012-08-02

    ... Supervision and Administration Commission of the State Council (``SASAC'') and CXS's ultimate corporate parent... government is involved in the operations of CSSC and CXS and (2) the fundamental role of these companies in... profits and finance losses.\\62\\ Therefore, the Department has preliminarily determined that the...

  16. 77 FR 32531 - Circular Welded Carbon-Quality Steel Pipe From the Sultanate of Oman: Preliminary Determination...

    Science.gov (United States)

    2012-06-01

    ... Print Graphics Using Sheet-Fed Presses From Indonesia: Final Determination of Sales at Less Than Fair... selling expenses (including commissions and bank charges), and billing adjustments. See the Al Jazeera... appropriate, circumstance-of-sale adjustments (i.e., bank charges). We added U.S. packing costs and...

  17. Progesterone stimulates adipocyte determination and differentiation 1/sterol regulatory element-binding protein 1c gene expression. potential mechanism for the lipogenic effect of progesterone in adipose tissue.

    Science.gov (United States)

    Lacasa, D; Le Liepvre, X; Ferre, P; Dugail, I

    2001-04-13

    Fatty acid synthase (FAS), a nutritionally regulated lipogenic enzyme, is transcriptionally controlled by ADD1/SREBP1c (adipocyte determination and differentiation 1/sterol regulatory element-binding protein 1c), through insulin-mediated stimulation of ADD1/SREBP1c expression. Progesterone exerts lipogenic effects on adipocytes, and FAS is highly induced in breast tumor cell lines upon progesterone treatment. We show here that progesterone up-regulates ADD1/SREBP1c expression in the MCF7 breast cancer cell line and the primary cultured preadipocyte from rat parametrial adipose tissue. In MCF7, progesterone induced ADD1/SREBP1c and Metallothionein II (a well known progesterone-regulated gene) mRNAs, with comparable potency. In preadipocytes, progesterone increased ADD1/SREBP1c mRNA dose-dependently, but not SREBP1a or SREBP2. Run-on experiments demonstrated that progesterone action on ADD1/SREBP1c was primarily at the transcriptional level. The membrane-bound and mature nuclear forms of ADD1/SREBP1 protein accumulated in preadipocytes cultured with progesterone, and FAS induction could be abolished by adenovirus-mediated overexpression of a dominant negative form of ADD1/SREBP1 in these cells. Finally, in the presence of insulin, progesterone was unable to up-regulate ADD1/SREBP1c mRNA in preadipocytes, whereas its effect was restored after 24 h of insulin deprivation. Together these results demonstrate that ADD1/SREBP1c is controlled by progesterone, which, like insulin, acts by increasing ADD1/SREBP1c gene transcription. This provides a potential mechanism for the lipogenic actions of progesterone on adipose tissue.

  18. Preliminary research to determine stress districts from focal mechanism solutions in Southwest China and its adjacent area

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    The method of sliding direction fitting is used to determine stress districts, taking the shear stress directions and ratios of shear stress to stress on fault planes given by focal mechanism solutions as the criteria to select focal mechanism solutions of one region and sorting out the earthquakes controlled by different tectonic stress fields, and then determining the stress districts from epicenter distribution of earthquakes. We call this method as step by step convergence method. By inversion analyzing of 297 focal mechanism solutions, we consider that Southwest China and its adjacent area can be divided into 5 stress districts, and we worked out directions of the three principal stresses and values of shape factor φin 5 stress districts.

  19. The Prevalence of Fibromyalgia in Postmenopausal Osteoporotic Women and to Determination of Related Risk Factors (Preliminary Study

    Directory of Open Access Journals (Sweden)

    Şule Şahin Onat

    2014-04-01

    Full Text Available Objective: The purpose of the study was to determine the prevalence of fibromyalgia in postmenopausal women with osteoporosis and to determine the associated factors with fibromyalgia. Materials and Methods: Hundred thirty-seven postmenopausal women with osteoporosis admitted to our outpatient clinic were included in the study. A questionnaire that was including patients’age, marital status, education level, occupation, height, weight was completed. Risk factors of osteoporosis were recorded. major and minor risk factors were determined according to Canadian diagnosis and treatment guideline. DXA was used to determine bone mineral density of the lumbar spine and femoral neck. Thoracal and lumbar compression fractures were evaulated with thoracal and lumbar radiography. The diagnosis of fibromyalgia was according to the 1990 American College of Rheumatology (ACR criteria. Results: Twenty-six (19% of 137 postmenopausal women with osteoporosis had fibromyalgia. Ninety-four (68.6% of all patients were married and 43 (31.4% of all patients were not married, 63 (46% of all patients were literate, 74 (54% of all patients were illiterate. The average age of patients was 73.56±6.17. According to the results of logistic regression analysis, advanced age, to be married, the number of major risk factors and the decrease of lomber and femur bone mineral density were found to be risk factors for fibromyalgia. Educational level, BMI and the number of minor risk factors were not found to be a risk factors for fibromyalgia. Conclusion: It is importatnt to be careful for fibromyalgia not only in premenopousal women but also in postmenopausal osteoporotic women. (Turkish Journal of Osteoporosis 2014;20: 1-5

  20. Hypocenter Determination Using a Non-Linear Method for Events in West Java, Indonesia: A Preliminary Result

    Science.gov (United States)

    Rosalia, Shindy; Widiyantoro, Sri; Nugraha, Andri Dian; Ash Shiddiqi, Hasbi; Supendi, Pepen; Wandono

    2017-04-01

    West Java, part of the Sunda Arc, has relatively high seismicity due to subduction activity and faulting. The first step of tomography study in order to infer the geometry of the structure beneath West Java is to conduct precise earthquake hypocenter determination. In this study, we used earthquake waveform data taken from the regional Meteorological, Climatological, Geophysical Agency (BMKG) network from South Sumatra to central Java. We have repicked P and S arrival times from about 800 events in the period from April 2009 to December 2015. We selected the events which have azimuthal gap program to determine the earthquake hypocenters. The hypocenter location results give better clustering earthquakes which are correlated well with geological structure in the study region. We also compared our results with BMKG catalog data and found that the average hypocenter location difference is about 12 km in latitude direction, 9.5 km in longitude direction, and the average focal depth difference is about 19.5 km. For future studies, we will conduct tomographic imaging to invert 3-D seismic velocity structure beneath the western part of Java.

  1. Earthquake location determination using data from DOMERAPI and BMKG seismic networks: A preliminary result of DOMERAPI project

    Science.gov (United States)

    Ramdhan, Mohamad; Nugraha, Andri Dian; Widiyantoro, Sri; Métaxian, Jean-Philippe; Valencia, Ayunda Aulia

    2015-04-01

    DOMERAPI project has been conducted to comprehensively study the internal structure of Merapi volcano, especially about deep structural features beneath the volcano. DOMERAPI earthquake monitoring network consists of 46 broad-band seismometers installed around the Merapi volcano. Earthquake hypocenter determination is a very important step for further studies, such as hypocenter relocation and seismic tomographic imaging. Ray paths from earthquake events occurring outside the Merapi region can be utilized to delineate the deep magma structure. Earthquakes occurring outside the DOMERAPI seismic network will produce an azimuthal gap greater than 1800. Owing to this situation the stations from BMKG seismic network can be used jointly to minimize the azimuthal gap. We identified earthquake events manually and carefully, and then picked arrival times of P and S waves. The data from the DOMERAPI seismic network were combined with the BMKG data catalogue to determine earthquake events outside the Merapi region. For future work, we will also use the BPPTKG (Center for Research and Development of Geological Disaster Technology) data catalogue in order to study shallow structures beneath the Merapi volcano. The application of all data catalogues will provide good information as input for further advanced studies and volcano hazards mitigation.

  2. The determination of male adult age at death by central and posterior coxal analysis--a preliminary study.

    Science.gov (United States)

    Rougé-Maillart, Clotilde; Telmon, Norbert; Rissech, Carme; Malgosa, Assumption; Rougé, Daniel

    2004-03-01

    In forensic anthropological analysis, the pelvis is of particular interest as it is often a comparatively well-preserved part of the skeleton. This study in age determination uses the acetabulum, the central element of the pelvis, as a complement to the examination of the auricular surface. The test sample consisted of 30 individuals. First, the authors studied the auricular surface using the Lovejoy criteria. Second, they isolated four criteria based on chronological changes in the acetabulum. Third, they conducted an evaluation of each of these variables. The study examines the correlation between these criteria and the age of the individuals. A significant correlation was found between the acetabular criteria and age, and between the acetabular criteria and the Lovejoy criteria of the auricular surface. For forensic purposes, the acetabulum is an effective predictor in the determination of age. This newly proposed method explores the same criteria of ageing as the Lovejoy method. The combination of the two methods produces relatively consistent results in the estimation of age.

  3. Earthquake location determination using data from DOMERAPI and BMKG seismic networks: A preliminary result of DOMERAPI project

    Energy Technology Data Exchange (ETDEWEB)

    Ramdhan, Mohamad [Study Program of Earth Science, Institut Teknologi Bandung, Jl. Ganesa 10, Bandung, 40132 (Indonesia); Agency for Meteorology, Climatology and Geophysics of Indonesia (BMKG) Jl. Angkasa 1 No. 2 Kemayoran, Jakarta Pusat, 10720 (Indonesia); Nugraha, Andri Dian; Widiyantoro, Sri [Global Geophysics Research Group, Faculty of Mining and Petroleum Engineering, Institut TeknologiBandung, Jl. Ganesa 10, Bandung, 40132 (Indonesia); Métaxian, Jean-Philippe [Institut de Recherche pour le Développement (IRD) (France); Valencia, Ayunda Aulia, E-mail: mohamad.ramdhan@bmkg.go.id [Study Program of Geophysical Engineering, Institut Teknologi Bandung, Jl. Ganesa 10, Bandung, 40132 (Indonesia)

    2015-04-24

    DOMERAPI project has been conducted to comprehensively study the internal structure of Merapi volcano, especially about deep structural features beneath the volcano. DOMERAPI earthquake monitoring network consists of 46 broad-band seismometers installed around the Merapi volcano. Earthquake hypocenter determination is a very important step for further studies, such as hypocenter relocation and seismic tomographic imaging. Ray paths from earthquake events occurring outside the Merapi region can be utilized to delineate the deep magma structure. Earthquakes occurring outside the DOMERAPI seismic network will produce an azimuthal gap greater than 180{sup 0}. Owing to this situation the stations from BMKG seismic network can be used jointly to minimize the azimuthal gap. We identified earthquake events manually and carefully, and then picked arrival times of P and S waves. The data from the DOMERAPI seismic network were combined with the BMKG data catalogue to determine earthquake events outside the Merapi region. For future work, we will also use the BPPTKG (Center for Research and Development of Geological Disaster Technology) data catalogue in order to study shallow structures beneath the Merapi volcano. The application of all data catalogues will provide good information as input for further advanced studies and volcano hazards mitigation.

  4. Preliminary investigations on the determination of three-dimensional dose distributions using scintillator blocks and optical tomography

    Energy Technology Data Exchange (ETDEWEB)

    Kroll, Florian; Karsch, Leonhard [OncoRay - National Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, TU Dresden, 01307 Dresden (Germany); Pawelke, Jörg [OncoRay - National Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, TU Dresden, 01307 Dresden, Germany and Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiation Physics, P.O. Box 510119, 01314 Dresden (Germany)

    2013-08-15

    Purpose: Clinical QA in teletherapy as well as the characterization of experimental radiation sources for future medical applications requires effective methods for measuring three-dimensional (3D) dose distributions generated in a water-equivalent medium. Current dosimeters based on ionization chambers, diodes, thermoluminescence detectors, radiochromic films, or polymer gels exhibit various drawbacks: High quality 3D dose determination is either very sophisticated and expensive or requires high amounts of effort and time for the preparation or read out. New detectors based on scintillator blocks in combination with optical tomography are studied, since they have the potential to facilitate the desired cost-effective, transportable, and long-term stable dosimetry system that is able to determine 3D dose distributions with high spatial resolution in a short time.Methods: A portable detector prototype was set up based on a plastic scintillator block and four digital cameras. During irradiation the scintillator emits light, which is detected by the fixed cameras. The light distribution is then reconstructed by optical tomography, using maximum-likelihood expectation maximization. The result of the reconstruction approximates the 3D dose distribution. First performance tests of the prototype using laser light were carried out. Irradiation experiments were performed with ionizing radiation, i.e., bremsstrahlung (6 to 21 MV), electrons (6 to 21 MeV), and protons (68 MeV), provided by clinical and research accelerators.Results: Laser experiments show that the current imaging properties differ from the design specifications: The imaging scale of the optical systems is position dependent, ranging from 0.185 mm/pixel to 0.225 mm/pixel. Nevertheless, the developed dosimetry method is proven to be functional for electron and proton beams. Induced radiation doses of 50 mGy or more made 3D dose reconstructions possible. Taking the imaging properties into account, determined

  5. 78 FR 9687 - Prineville Energy Storage, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2013-02-11

    ... Energy Regulatory Commission Prineville Energy Storage, LLC; Notice of Preliminary Permit Application..., 2012, Prineville Energy Storage, LLC, filed an application for a preliminary permit, pursuant to...-hours. Applicant Contact: Mr. Matthew Shapiro, Chief Executive Officer, Prineville Energy Storage,...

  6. 76 FR 6459 - Mahoning Hydropower, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2011-02-04

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Mahoning Hydropower, LLC; Notice of Preliminary Permit Application Accepted.... On December 30, 2010, Mahoning Hydropower, LLC filed an application for a preliminary permit...

  7. 76 FR 7838 - Mahoning Hydropower, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2011-02-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Mahoning Hydropower, LLC; Notice of Preliminary Permit Application Accepted.... On December 30, 2010, Mahoning Hydropower, LLC filed an application for a preliminary permit...

  8. Preliminary study of the influence of red blood cells morphometry on the species determinism of domestic animals

    Directory of Open Access Journals (Sweden)

    Nezar Adili

    2014-04-01

    Full Text Available Aim: This survey was realized on cattle, sheep, goats, horses, and dogs, in order to study the influence of three morphometric parameters: the diameter, the circumference and the surface of red blood cells on the determinism of these species. Materials and Methods: For each species, blood samples were taken from 15 adult female by jugular venipuncture with confection of blood smears on microscope slides immediately after blood collection and stained according to the method of May-Gründwald Giemsa. Morphometric study was realized using the software OPTIKA Pro Vision. To better describe the results, the statistical analysis was assessed by using the descriptive Boxplots test, ANOVA, and the Student's t-test. Results: The morphometric parameters of red blood cells are biggest in dogs followed by horses, cattle, and sheep, while goats have the lowest ones. Conclusion: This investigation allowed us to show that from a drop of blood we can have an idea about the animal species taking into account the diameter, the circumference, and the surface of erythrocytes.

  9. Experience and BCC subtypes as determinants of MAL-PDT response: preliminary results of a national Brazilian project.

    Science.gov (United States)

    Ramirez, Dora P; Kurachi, Cristina; Inada, Natalia M; Moriyama, Lilian T; Salvio, Ana G; Vollet Filho, José D; Pires, Layla; Buzzá, Hilde H; de Andrade, Cintia Teles; Greco, Clovis; Bagnato, Vanderlei S

    2014-03-01

    Non-melanoma skin cancer is the most prevalent cancer type in Brazil and worldwide. Photodynamic therapy (PDT) is a noninvasive technique with excellent cosmetic outcome and good curative results, when used for the initial stages of skin cancer. A Brazilian program was established to determine the efficacy of methyl aminolevulinate (MAL)-PDT, using Brazilian device and drug. The equipment is a dual device that combines the photodiagnosis, based on widefield fluorescence, and the treatment at 630nm. A protocol was defined for the treatment of basal cell carcinoma with 20% MAL cream application. The program also involves the training of the medical teams at different Brazilian regions, and with distinct facilities and previous PDT education. In this report we present the partial results of 27 centers with 366 treated BCC lesions in 294 patients. A complete response (CR) was observed in 76.5% (280/366). The better response was observed for superficial BCC, with CR 160 lesions (80.4%), when compared with nodular or pigmented BCC. Experienced centers presented CR of 85.8% and 90.6% for superficial and nodular BCC respectively. A high influence of the previous doctor experience on the CR values was observed, especially due to a better tumor selection.

  10. Determination of regulatory phosphorylation sites in nanogram amounts of a synthetic fragment of ZAP-70 using microprobe NMR and on-line coupled capillary HPLC-NMR

    NARCIS (Netherlands)

    Hentschel, P; Krucker, M; Grynbaum, MD; Putzbach, K; Bischoff, R; Albert, K

    2005-01-01

    The protein kinase ZAP-70 is involved in T-cell activation and interacts with tyrosine-phosphorylated peptide sequences known as immunoreceptor tyrosine activation motifs (ITAMs). We have studied the regulatory phosphorylation sites in the tryptic fragment containing amino acids 485-496 (ALGADDSYYTA

  11. Antimicrobial susceptibility determined by the E test, Löwenstein-Jensen proportion, and DNA sequencing methods among Mycobacterium tuberculosis isolates discrepancies, preliminary results

    Directory of Open Access Journals (Sweden)

    Maria Inês Moura Freixo

    2004-02-01

    Full Text Available Mycobacterium tuberculosis strains resistant to streptomycin (SM, isoniazid (INH, and/or rifampin (RIF as determined by the conventional Löwenstein-Jensen proportion method (LJPM were compared with the E test, a minimum inhibitory concentration susceptibility method. Discrepant isolates were further evaluated by BACTEC and by DNA sequence analyses for mutations in genes most often associated with resistance to these drugs (rpsL, katG, inhA, and rpoB. Preliminary discordant E test results were seen in 75% of isolates resistant to SM and in 11% to INH. Discordance improved for these two drugs (63% for SM and none for INH when isolates were re-tested but worsened for RIF (30%. Despite good agreement between phenotypic results and sequencing analyses, wild type profiles were detected on resistant strains mainly for SM and INH. It should be aware that susceptible isolates according to molecular methods might contain other mechanisms of resistance. Although reproducibility of the LJPM susceptibility method has been established, variable E test results for some M. tuberculosis isolates poses questions regarding its reproducibility particularly the impact of E test performance which may vary among laboratories despite adherence to recommended protocols. Further studies must be done to enlarge the evaluated samples and looked possible mutations outside of the hot spot sequenced gene among discrepant strains.

  12. A simplified modification of the AOAC official method for determination of total dietary fiber using newly developed enzymes: preliminary interlaboratory study.

    Science.gov (United States)

    Kanaya, Kenichiro; Tada, Shusaku; Mori, Bunpei; Takahashi, Rie; Ikegami, Sachie; Kurasawa, Shin'ichi; Okuzaki, Masami; Mori, Yoko; Innami, Satoshi

    2007-01-01

    A preliminary interlaboratory study was conducted to evaluate the validity of the modified AOAC method for determination of total dietary fiber by Tada and Innami, in which the 3-step enzymatic digestion process in AOAC Method 991.43 is modified to a 2-step process without pH adjustment. Total dietary fiber contents in 8 representative foodstuffs were measured using both the original AOAC Method 991.43 and the modified method in 6 research facilities in Japan. Repeatability relative standard deviations, reproducibility relative standard deviations, and Horwitz ratio values from the modified method were equivalent to those from AOAC Method 991.43, except in the rice sample. However, this exceptional case shown in the modified method was entirely dissolved by the addition of alpha-amylase stabilizing agents. The modified method, which shortens the process of enzymatic digestion from 3 to 2 steps and in which only reaction temperature is adjusted under the same pH, was found not only to give accurate values comparable to the original method, but also to substantially reduce the labor required by the laboratory staff in the process of routine analysis. This study revealed that the validity of the modified method was further ensured by adding alpha-amylase stabilizing agents to the reaction system.

  13. Preliminary determination of calcium, phosphorus, and the calcium/phosphorus ratio in cortical bone of Chinstrap penguin using synchrotron X-ray fluorescence analysis

    Institute of Scientific and Technical Information of China (English)

    Xie Zhouqing; Cheng Bangbo; Sun Liguang; Huang Yuying; He Wei; Zhao Sanping

    2006-01-01

    Synchrotron radiation X-ray fluorescence (SR-XRF) approach was applied to analyzing of Chinstrap penguin (Pygoscelis Antarctica) cortical bone. The method enabled the in situ determination of Ca and P concentrations and the Ca/P ratio in cortical bone. The preliminary results show that: (1) there is the bone site-related difference for Ca and P concentrations. The mean values for the investigated parameters ( on a dry-weight basis) are: 30.7% (Ca) and 14.9% (P) for the femoral cortical bone, 21.4% (Ca) and 11.5% (P) for wing cortical bone. (2) The variation for the Ca/P ratio in cortical bone is lower than those for Ca and P separately.This is in agreement with the previous report that the specificity of the Ca/P ratio is better than that of Ca and P concentrations and is more reliable for the diagnosis of bone disorders. The authors suggest that further studies be conducted to establish normal values of Ca, P and Ca/P ratio for polar animals and provide a basis for the diagnosis of bone disorders.

  14. Repository Subsurface Preliminary Fire Hazard Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Richard C. Logan

    2001-07-30

    This fire hazard analysis identifies preliminary design and operations features, fire, and explosion hazards, and provides a reasonable basis to establish the design requirements of fire protection systems during development and emplacement phases of the subsurface repository. This document follows the Technical Work Plan (TWP) (CRWMS M&O 2001c) which was prepared in accordance with AP-2.21Q, ''Quality Determinations and Planning for Scientific, Engineering, and Regulatory Compliance Activities''; Attachment 4 of AP-ESH-008, ''Hazards Analysis System''; and AP-3.11Q, ''Technical Reports''. The objective of this report is to establish the requirements that provide for facility nuclear safety and a proper level of personnel safety and property protection from the effects of fire and the adverse effects of fire-extinguishing agents.

  15. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in Vermont. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D A; Weaver, C L; Gallagher, K C; Hejna, D; Rielley, K J

    1980-01-01

    The authority to regulate public utilities is vested generally in the Vermont Public Service Board (PSC). The PSB is comprised of three members appointed by the governor with the advice and consent of the senate. PSB members serve six year terms. Members must be free from any employment or pecuniary interests in any company subject to the supervision of the PSB. Local governments retain little regulatory authority over public utilities. Local governments are responsible for regulating the use of streets and other public property, but any person aggrieved by a local decision may appeal to the PSB within thirty days. The PSB is to review the local action at a public hearing and its decision is final. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  16. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in California. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D.A.; Weaver, C.L.; Gallagher, K.C.; Hejna, D.; Rielley, K.J.

    1980-01-01

    The Constitution of the State of California grants to the Legislature control over persons and private corporations that own or operate a line, plant, or system for the production, generation, or transmission of heat, light, water, or power to be furnished either directly or indirectly to or for the public. The Constitution establishes the Public Utilities Commission and grants certain specific powers to the PUC, including the power to fix rates, establish rules and prescribe a uniform system of accounts. The Constitution also recognizes that the Legislature has plenary power to confer additional authority and jurisdiction upon the PUC. The Constitution prohibits regulation by a city, county, or other municipal body of matters over which the Legislature has granted regulatory power to the PUC. This provision does not, however, impair the right of any city to grant franchises for public utilities. The California legislature has enacted the California Public Utilities Code and has designated the PUC as the agency to implement the regulatory provisions of the Code. The Public Utilities Commission consists of five members appointed by the governor and approved by the senate, a majority of the membership concurring, for staggered 6-year terms. Certain limited powers over the conduct of public utilities may still be exercised by municipalities. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  17. 75 FR 56608 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving...

    Science.gov (United States)

    2010-09-16

    ... uniform, market-wide trading pauses will serve to prevent potentially destabilizing price volatility and... public interest. II. Description of the Proposals On May 6, 2010, the U.S. equity markets experienced a... Emerging Regulatory Issues, ``Preliminary Findings Regarding the Market Events of May 6, 2010,'' dated May...

  18. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in Maryland. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D A; Weaver, C L; Gallagher, K C; Hejna, D; Rielley, K J

    1980-01-01

    The authority to regulate public utilities in Maryland is vested in the Public Service Commission under the authority of the Public Service Commission Law. The Commission consists of five commissioners who are appointed by the governor with the advice and consent of the Senate. Commissioners must be or become citizens of Maryland, at least three are to serve full time, and one of the commissioners is to be nominated as chairman. The tenure of each commissioner is six years and their terms are on a staggered schedule. Commissioners are eligible for reappointment. The Public Service Commission Law provides that the Commission's powers an jurisdiction shall extend to the full extent permitted by the Constitution and laws of the United States. Local governments in Maryland are not given regulatory power over public service companies. The only power that local governments have over the operations of utilities is the power to grant franchises. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  19. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in Maine. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D A; Weaver, C L; Gallagher, K C; Hejna, D; Rielley, K J

    1980-01-01

    The Maine Supreme Court holds that the regulation of the operations of public utilities is an exercise of the police powers of the state. The legislature has delegated such regulatory authority to the Maine Public Utilities Commission (PUC). The statutes provide no role for local government in the regulation of public utilities. The PUC consists of three full time members, appointed by the Governor subject to review by the Joint Standing Committee on Public Utilities and to confirmation by the Legislature. They each serve seven year terms. One member is designated by the Governor as chairman. The Commission appoints a secretary, assistant secretary, director of transportation, and, with the approval of the Attorney General, a general counsel. A member of the PUC cannot have any official or professional connection or relation with or hold any stock or securities in any public utility. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  20. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in Iowa. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D A; Weaver, C L; Gallagher, K C; Hejna, D; Rielley, K J

    1980-01-01

    The authority to regulate public utilities is vested generally in the Iowa State Commerce Commission. The Commission is comprised of three members appointed by the governor with the approval of two-thirds of the senate. Commissioners are appointed for six-year terms. They must be free from employment or pecuniary interests in any public utility. Although the right to grant franchises is specifically reserved for municipalities, local governments exercise no regulatory authority over the provision of utility services by public utilities. Municipally-owned utilities, however, are specifically excepted from rate regulation by the Commission. The regulation of rates charged by municipally-owned utilities is the responsibility of local governments. The Commission is given no authority to review decisions of local governments with respect to rates. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  1. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in South Carolina. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D A; Weaver, C L; Gallagher, K C; Hejna, D; Rielley, K J

    1980-01-01

    Pursuant to constitutional South Carolina mandate the General Assembly has created the Public Service Commission. The Commission is composed of seven members elected to four year terms by the General Assembly. One commissioner is elected from each of seven districts corresponding to the congressional districts as they existed as of January 1, 1930. The commissioners elect one of their members as chairman. The South Carolina statutes contain separate chapters dealing with the regulation of public utilities and electric utilities. Public utility includes the furnishing of gas or heat (other than by means of electricity) to the public. While the Commission is granted general supervisory and regulatory powers over public utilities and electric utilities, total governments retain some control over electrical utilities. All municipality's have the power to grant exclusive franchises to such utilities for the furnishing of light to the municipality and its inhabitants. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  2. Ship design methodologies of preliminary design

    CERN Document Server

    Papanikolaou, Apostolos

    2014-01-01

    This book deals with ship design and in particular with methodologies of the preliminary design of ships. The book is complemented by a basic bibliography and five appendices with useful updated charts for the selection of the main dimensions and other basic characteristics of different types of ships (Appendix A), the determination of hull form  from the data of systematic hull form series (Appendix B), the detailed description of the relational method for the preliminary estimation of ship weights (Appendix C), a brief review of the historical evolution of shipbuilding science and technology from the prehistoric era to date (Appendix D) and finally a historical review of regulatory developments of ship's damage stability to date (Appendix E).  The book can be used as textbook for ship design courses or as additional reading for university or college students of naval architecture courses and related disciplines; it may also serve as a reference book for naval architects, practicing engineers of rel...

  3. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in Florida. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D A; Weaver, C L; Gallagher, K C; Hejna, D; Rielley, K J

    1980-01-01

    The authority to regulate public utilities is vested generally in the Florida Public Service Commission. The Commission is comprised of five members appointed by the governor with the approval of the senate. The governor must choose his appointees from a list of persons recommended by the nine-person Florida Public Service Commission Nominating Council. Commissioners serve either three- or four-year terms. They must be free from any employment or pecuniary interests in any utility subject to the jurisdiction of the Commission. Within the purview of its powers, the authority of the Commission supersedes that of local governments. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  4. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in New Hampshire. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D A; Weaver, C L; Gallagher, K C; Hejna, D; Rielley, K J

    1980-01-01

    Public utilities in New Hampshire are regulated by the Public Utilities Commission. The Commission is comprised of three members appointed for six-year terms by the Governor with the advice and consent of the council. Members of the Commission must be free from any employment or pecuniary interests in any public utility. The Commission is charged with the general regulation and supervision of public utilities. Within the purview of its powers, the authority of the Commission supercedes that of local government. The Commission may suspend the operation of local zoning laws. Local governments do retain the right to license the use of public ways by utilities. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  5. The origin of thymic CD4+CD25+ regulatory T cells and their co-stimulatory requirements are determined after elimination of recirculating peripheral CD4+ cells.

    Science.gov (United States)

    Zhan, Yifan; Bourges, Dorothee; Dromey, James A; Harrison, Leonard C; Lew, Andrew M

    2007-04-01

    Studies on the thymic ontogeny of naturally arising CD4(+)CD25(+) regulatory T cells (TR cells) are complicated by the contamination of recirculating cells from the periphery (both activated CD4(+) T and TR cells). We investigated TR cells in anti-CD4 antibody transgenic (Tg) (GK) mice that continuously deplete peripheral CD4 T cells but not thymocytes so that the generation of thymic TR cells and their developmental requirement can be accurately assessed. We show that in the thymuses of mice that lack peripheral CD4(+) cells, TR cells were present but were fewer in number compared with wild-type (WT) mice. Therefore, we show that peripheral TR cells do re-enter the thymus, comprising 20% of TR cells in the normal thymus. TR cells from both WT and GK mice expressed Foxp3 and GITR, and suppressed the proliferation of CD25(-)CD4(+) T cells. Furthermore, the co-stimulation requirements for TR generation were evaluated in mice with or without peripheral CD4 cells. Splenic TR cells in CD40L(-/-) mice and CTLA4Ig Tg mice were fewer compared with WT mice. Mice deficient in both co-stimulatory pathways had further reduction in splenic TR cells. Unlike the periphery, the reduction in thymic TR cells was only seen for CD40L(-/-) but not for CTLA4Ig Tg mice. Therefore, we found that the co-stimulation requirements for the thymic development of TR cells differed from those for peripheral homeostasis.

  6. The core regulatory network in human cells.

    Science.gov (United States)

    Kim, Man-Sun; Kim, Dongsan; Kang, Nam Sook; Kim, Jeong-Rae

    2017-03-04

    In order to discover the common characteristics of various cell types in the human body, many researches have been conducted to find the set of genes commonly expressed in various cell types and tissues. However, the functional characteristics of a cell is determined by the complex regulatory relationships among the genes rather than by expressed genes themselves. Therefore, it is more important to identify and analyze a core regulatory network where all regulatory relationship between genes are active across all cell types to uncover the common features of various cell types. Here, based on hundreds of tissue-specific gene regulatory networks constructed by recent genome-wide experimental data, we constructed the core regulatory network. Interestingly, we found that the core regulatory network is organized by simple cascade and has few complex regulations such as feedback or feed-forward loops. Moreover, we discovered that the regulatory links from genes in the core regulatory network to genes in the peripheral regulatory network are much more abundant than the reverse direction links. These results suggest that the core regulatory network locates at the top of regulatory network and plays a role as a 'hub' in terms of information flow, and the information that is common to all cells can be modified to achieve the tissue-specific characteristics through various types of feedback and feed-forward loops in the peripheral regulatory networks. We also found that the genes in the core regulatory network are evolutionary conserved, essential and non-disease, non-druggable genes compared to the peripheral genes. Overall, our study provides an insight into how all human cells share a common function and generate tissue-specific functional traits by transmitting and processing information through regulatory network.

  7. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in North Carolina. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D A; Weaver, C L; Gallagher, K C; Hejna, D; Rielley, K J

    1980-01-01

    Under the Public Utilities Act of 1965, utilities in North Carolina are regulated by the State's Utility Commission. The Commission consists of seven members who are appointed by the governor, subject to confirmation by the General Assembly sitting in joint session. The Commissioners serve eight year terms and the governor designates one of the commissioners as chairman. The Commission has an office of the executive director, who is appointed to a six year term by the governor subject to confirmaion by the General Assembly. The executive director heads the Commission's public staff. The public staff's duties include reviewing, investigating, and making recommendations on utility rates and services and intervention on behalf of the public in proceedings affecting consumer rates and generating plant certification. The Commission has the same power to regulate the operation of privately-owned public utilities within municipalities as it has to control those ouside. The only power over privately-owned utilities reserved to the municipalities is the power to grant franchises. A municipality may maintain its own utility systems, and such systems are not subject to the control and jurisdiction of the Commission. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  8. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in Pennsylvania. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D A; Weaver, C L; Gallagher, K C; Hejna, D; Rielley, K J

    1980-01-01

    The authority to regulate public utilities is generally vested in the Pennsylvania Public Utility Commission. The Commission is comprised of five members appointed by the governor with the advice and consent of two-thirds of the senate. Commission members are appointed for 10 year terms. They must be free from any employment which is incompatible with the duties of the Commission, and are subject to a statutory code of ethics. The Commission is charged with responsibility for enforcing the Public Utility Law. Within the purview of its powers, the authority of the Commission supersedes that of local governments. The Commission, for example, may grant exemptions from local zoning requirements, and has approving authority over privileges or franchises granted by municipalities to public utilities. The Commission, however, has no authority over municipally owned utilities operating within municipal boundaries. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  9. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in Rhode Island. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D A; Weaver, C L; Gallagher, K C; Hejna, D; Rielley, K J

    1980-01-01

    The Rhode Island statutes vest in the Public Utility Commission and the Division of Public Utilities the exclusive power and authority to regulate public utility companies in that state. Both bodies have been established within the Department of Business Regulation but are independent of the Department's director and are not under his jurisdiction. The jurisdiction to regulate utilities is shared by the Commission and the Division. The Commission serves as a quasi-judicial tribunal with jurisdiction, powers, and duties to hold investigations and hearings involving rates, sufficiency and resonableness of facilities, gas, electric, water, and pipeline public utilities. The administrator, who is chief executive officer of the Division, is responsible for exercising the jurisdiction, supervision, powers, and duties not specifically assigned to the Commission. By virtue of his office, the chairman of the Commission serves also as the administrator and he supervises and directs the execution of all laws relating to public utilities and carriers and all regulations and orders of the Commission governing the conduct and charges of public utilities. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  10. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in Michigan. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D A; Weaver, C L; Gallagher, K C; Hejna, D; Rielley, K J

    1980-01-01

    The authority to regulate public utilities is vested generally in the Michigan Public Service Commission. The Commission is composed of three members appointed by the Governor with the advice and consent of the senate. Commission members are appointed for six-year terms. They must be free from pecuniary and employment interests incompatible with the duties of the Commission. The Commission is vested with complete power and jurisdiction to regulate all public utilities in the state except any municipally-owned utility. The Commission may not change any rates fixed in or regulated by a franchise granted by a municipality. Upon submission to the Commission by the municipality and the public utility operating in the municipality, the Commission may investigate and fix rates and establish rules and conditions of service. The jurisdiction of the Commission extends to all public utilities except municipally-owned utilities. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  11. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in South Dakota. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D A; Weaver, C L; Gallagher, K C; Hejna, D; Rielley, K J

    1980-01-01

    The South Dakota Public Utilities Commission is authorized by statute to regulate gas and electric utilities. The Commission consists of three elected commissioners each of whom serves for a six year term. The Commissioners are elected by district and each must, at the time of election, be a resident of the district from which he has been elected. Each Commissioner must reside in the state capital and devote his entire time to the duties of his office. The Commission is part of the Department of Commerce and Consumer Protection. Municipal power to regulate privately owned electric and gas public utilities was terminated in 1975. A municipally-owned electric utility has the authority to regulate the sale, use, and rates of electric power and energy which it provides. The Commission has no authority to regulate steam, heat, and refrigeration systems; that power resides in cities. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  12. Prolonged graft survival in older recipient mice is determined by impaired effector T-cell but intact regulatory T-cell responses.

    Directory of Open Access Journals (Sweden)

    Christian Denecke

    Full Text Available Elderly organ transplant recipients represent a fast growing segment of patients on the waiting list. We examined age-dependent CD4(+ T-cell functions in a wild-type (WT and a transgenic mouse transplant model and analyzed the suppressive function of old regulatory T-cells. We found that splenocytes of naïve old B6 mice contained significantly higher frequencies of T-cells with an effector/memory phenotype (CD4(+CD44(highCD62L(low. However, in-vitro proliferation (MLR and IFNgamma-production (ELISPOT were markedly reduced with increasing age. Likewise, skin graft rejection was significantly delayed in older recipients and fewer graft infiltrating CD4(+T-cells were observed. Old CD4(+ T-cells demonstrated a significant impaired responsiveness as indicated by diminished proliferation and activation. In contrast, old alloantigen-specific CD4(+CD25(+FoxP3(+ T-cells demonstrated a dose-dependent well-preserved suppressor function. Next, we examined characteristics of 18-month old alloreactive T-cells in a transgenic adoptive transfer model. Adoptively transferred old T-cells proliferated significantly less in response to antigen. Skin graft rejection was significantly delayed in older recipients, and graft infiltrating cells were reduced. In summary, advanced recipient age was associated with delayed acute rejection and impaired CD4(+ T-cell function and proliferation while CD4(+CD25(+FoxP3(+ T-cells (Tregs showed a well-preserved function.

  13. Determining

    Directory of Open Access Journals (Sweden)

    Bahram Andarzian

    2015-06-01

    Full Text Available Wheat production in the south of Khuzestan, Iran is constrained by heat stress for late sowing dates. For optimization of yield, sowing at the appropriate time to fit the cultivar maturity length and growing season is critical. Crop models could be used to determine optimum sowing window for a locality. The objectives of this study were to evaluate the Cropping System Model (CSM-CERES-Wheat for its ability to simulate growth, development, grain yield of wheat in the tropical regions of Iran, and to study the impact of different sowing dates on wheat performance. The genetic coefficients of cultivar Chamran were calibrated for the CSM-CERES-Wheat model and crop model performance was evaluated with experimental data. Wheat cultivar Chamran was sown on different dates, ranging from 5 November to 9 January during 5 years of field experiments that were conducted in the Khuzestan province, Iran, under full and deficit irrigation conditions. The model was run for 8 sowing dates starting on 25 October and repeated every 10 days until 5 January using long-term historical weather data from the Ahvaz, Behbehan, Dezful and Izeh locations. The seasonal analysis program of DSSAT was used to determine the optimum sowing window for different locations as well. Evaluation with the experimental data showed that performance of the model was reasonable as indicated by fairly accurate simulation of crop phenology, biomass accumulation and grain yield against measured data. The normalized RMSE were 3%, 2%, 11.8%, and 3.4% for anthesis date, maturity date, grain yield and biomass, respectively. Optimum sowing window was different among locations. It was opened and closed on 5 November and 5 December for Ahvaz; 5 November and 15 December for Behbehan and Dezful;and 1 November and 15 December for Izeh, respectively. CERES-Wheat model could be used as a tool to evaluate the effect of sowing date on wheat performance in Khuzestan conditions. Further model evaluations

  14. Feasibility of wavelength dispersive X-ray fluorescence spectrometry for the determination of metal impurities in pharmaceutical products and dietary supplements in view of regulatory guidelines.

    Science.gov (United States)

    Figueiredo, Alexandra; Fernandes, Tânia; Costa, Isabel Margarida; Gonçalves, Luísa; Brito, José

    2016-04-15

    The aim of this study was to investigate the feasibility of Wavelength Dispersive X-ray Fluorescence (WDXRF) spectrometry for the measurement of As, Cd, Cr, Cu, Hg, Ir, Mn, Mo, Ni, Os, Pb, Pd, Pt, Rh, Ru and V impurities in pharmaceuticals and dietary supplements, in view of the requirements by EMA and USP for the measurement of elemental impurities in drug products and according to the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH guidelines). For that purpose, a 4 kW WDXRF spectrometer (S4 Pioneer, Bruker AXS) was used after system calibration. The linearity of the method was demonstrated by correlation coefficients in excess of 0.9 and by appropriate test of lack of fit, except for Cd, Hg, Pd, V and As, which were excluded from analysis. The calculated limits of detection and quantification were in the ranges 0.6-5.4 μg/g and 1.7-16.4 μg/g meeting defined acceptance criteria, except for Pb. The accuracy of the method, determined by the percent recovery (R) of known amounts of each element added to a selected drug, at 3 different concentration levels, was in the acceptance range 70-150% except for Os and Pt, in which case R was marginally outside that range. The repeatability of the method, assessed as the % residual standard deviation (%RSD) of 3 replicate measurements at 3 concentration levels, produced %RSD values lower than 20%, as required. These results show that the WDXRF method complies with the validation requirements defined by the European Pharmacopeia for Cu, Cr, Ir, Mn, Mo, Ni, Os, and Pt, and by the United States Pharmacopeia for Ir, Ni, Os and Pt. Therefore, it may be an alternative to the compendial analytical procedures recommended for such elements. The novelty of the present work is the application of WDXRF to final medicines and not only to active pharmaceutical ingredients and/or excipients.

  15. Regulatory considerations for biosimilars

    Directory of Open Access Journals (Sweden)

    Ranjani Nellore

    2010-01-01

    Full Text Available Currently there is considerable interest in the legislative debate around generic biological drugs or "biosimilars" in the EU and US due to the large, lucrative market that it offers to the industry. While some countries have issued a few regulatory guidelines as well as product specific requirements, there is no general consensus as to a single, simple mechanism similar to the bioequivalence determination that leads to approval of generic small molecules all over the world. The inherent complex nature of the molecules, along with complicated manufacturing and analytical techniques to characterize them make it difficult to rely on a single human pharmacokinetic study for assurance of safety and efficacy. In general, the concept of comparability has been used for evaluation of the currently approved "similar" biological where a step by step assessment on the quality, preclinical and clinical aspects is made. In India, the focus is primarily on the availability and affordability of life-saving drugs. In this context every product needs to be evaluated on its own merit irrespective of the innovator brand. The formation of the National Biotechnology Regulatory Authority may provide a step in the right direction for regulation of these complex molecules. However, in order to have an efficient machinery for initial approval and ongoing oversight with a country-specific focus, cooperation with international authorities for granting approvals and continuous risk-benefit review is essential. Several steps are still needed for India to be perceived as a country that leads the world in providing quality biological products.

  16. Preliminary environmental analysis of a geopressured-geothermal test well in Brazoria County, Texas

    Energy Technology Data Exchange (ETDEWEB)

    White, W.A.; McGraw, M.; Gustavson, T.C.; Meriwether, J.

    1977-11-16

    Preliminary environmental data, including current land use, substrate lithology, soils, natural hazards, water resources, biological assemblages, meteorological data, and regulatory considerations have been collected and analyzed for approximately 150 km/sup 2/ of land near Chocolate Bayou, Brazoria County, Texas, in which a geopressured-geothermal test well is to be drilled in the fall of 1977. The study was designed to establish an environmental data base and to determine, within spatial constraints set by subsurface reservoir conditions, environmentally suitable sites for the proposed well. Preliminary analyses of data revealed the eed for focusing on the following areas: potential for subsidence and fault activation, susceptibility of test well and support facilities to fresh- and salt-water flooding, possible effects of produced saline waters on biological assemblages and groundwaer resources, distribution of expansive soils, and effect of drilling and associated support activities on known archeological-cultural resources.

  17. Adaptive Dynamics of Regulatory Networks: Size Matters

    Directory of Open Access Journals (Sweden)

    2009-03-01

    Full Text Available To accomplish adaptability, all living organisms are constructed of regulatory networks on different levels which are capable to differentially respond to a variety of environmental inputs. Structure of regulatory networks determines their phenotypical plasticity, that is, the degree of detail and appropriateness of regulatory replies to environmental or developmental challenges. This regulatory network structure is encoded within the genotype. Our conceptual simulation study investigates how network structure constrains the evolution of networks and their adaptive abilities. The focus is on the structural parameter network size. We show that small regulatory networks adapt fast, but not as good as larger networks in the longer perspective. Selection leads to an optimal network size dependent on heterogeneity of the environment and time pressure of adaptation. Optimal mutation rates are higher for smaller networks. We put special emphasis on discussing our simulation results on the background of functional observations from experimental and evolutionary biology.

  18. Adaptive Dynamics of Regulatory Networks: Size Matters

    Directory of Open Access Journals (Sweden)

    Martinetz Thomas

    2009-01-01

    Full Text Available To accomplish adaptability, all living organisms are constructed of regulatory networks on different levels which are capable to differentially respond to a variety of environmental inputs. Structure of regulatory networks determines their phenotypical plasticity, that is, the degree of detail and appropriateness of regulatory replies to environmental or developmental challenges. This regulatory network structure is encoded within the genotype. Our conceptual simulation study investigates how network structure constrains the evolution of networks and their adaptive abilities. The focus is on the structural parameter network size. We show that small regulatory networks adapt fast, but not as good as larger networks in the longer perspective. Selection leads to an optimal network size dependent on heterogeneity of the environment and time pressure of adaptation. Optimal mutation rates are higher for smaller networks. We put special emphasis on discussing our simulation results on the background of functional observations from experimental and evolutionary biology.

  19. An Lmx1b-miR135a2 regulatory circuit modulates Wnt1/Wnt signaling and determines the size of the midbrain dopaminergic progenitor pool.

    Directory of Open Access Journals (Sweden)

    Angela Anderegg

    Full Text Available MicroRNAs regulate gene expression in diverse physiological scenarios. Their role in the control of morphogen related signaling pathways has been less studied, particularly in the context of embryonic Central Nervous System (CNS development. Here, we uncover a role for microRNAs in limiting the spatiotemporal range of morphogen expression and function. Wnt1 is a key morphogen in the embryonic midbrain, and directs proliferation, survival, patterning and neurogenesis. We reveal an autoregulatory negative feedback loop between the transcription factor Lmx1b and a newly characterized microRNA, miR135a2, which modulates the extent of Wnt1/Wnt signaling and the size of the dopamine progenitor domain. Conditional gain of function studies reveal that Lmx1b promotes Wnt1/Wnt signaling, and thereby increases midbrain size and dopamine progenitor allocation. Conditional removal of Lmx1b has the opposite effect, in that expansion of the dopamine progenitor domain is severely compromised. Next, we provide evidence that microRNAs are involved in restricting dopamine progenitor allocation. Conditional loss of Dicer1 in embryonic stem cells (ESCs results in expanded Lmx1a/b+ progenitors. In contrast, forced elevation of miR135a2 during an early window in vivo phenocopies the Lmx1b conditional knockout. When En1::Cre, but not Shh::Cre or Nes::Cre, is used for recombination, the expansion of Lmx1a/b+ progenitors is selectively reduced. Bioinformatics and luciferase assay data suggests that miR135a2 targets Lmx1b and many genes in the Wnt signaling pathway, including Ccnd1, Gsk3b, and Tcf7l2. Consistent with this, we demonstrate that this mutant displays reductions in the size of the Lmx1b/Wnt1 domain and range of canonical Wnt signaling. We posit that microRNA modulation of the Lmx1b/Wnt axis in the early midbrain/isthmus could determine midbrain size and allocation of dopamine progenitors. Since canonical Wnt activity has recently been recognized as a key

  20. An Lmx1b-miR135a2 regulatory circuit modulates Wnt1/Wnt signaling and determines the size of the midbrain dopaminergic progenitor pool.

    Directory of Open Access Journals (Sweden)

    Angela Anderegg

    Full Text Available MicroRNAs regulate gene expression in diverse physiological scenarios. Their role in the control of morphogen related signaling pathways has been less studied, particularly in the context of embryonic Central Nervous System (CNS development. Here, we uncover a role for microRNAs in limiting the spatiotemporal range of morphogen expression and function. Wnt1 is a key morphogen in the embryonic midbrain, and directs proliferation, survival, patterning and neurogenesis. We reveal an autoregulatory negative feedback loop between the transcription factor Lmx1b and a newly characterized microRNA, miR135a2, which modulates the extent of Wnt1/Wnt signaling and the size of the dopamine progenitor domain. Conditional gain of function studies reveal that Lmx1b promotes Wnt1/Wnt signaling, and thereby increases midbrain size and dopamine progenitor allocation. Conditional removal of Lmx1b has the opposite effect, in that expansion of the dopamine progenitor domain is severely compromised. Next, we provide evidence that microRNAs are involved in restricting dopamine progenitor allocation. Conditional loss of Dicer1 in embryonic stem cells (ESCs results in expanded Lmx1a/b+ progenitors. In contrast, forced elevation of miR135a2 during an early window in vivo phenocopies the Lmx1b conditional knockout. When En1::Cre, but not Shh::Cre or Nes::Cre, is used for recombination, the expansion of Lmx1a/b+ progenitors is selectively reduced. Bioinformatics and luciferase assay data suggests that miR135a2 targets Lmx1b and many genes in the Wnt signaling pathway, including Ccnd1, Gsk3b, and Tcf7l2. Consistent with this, we demonstrate that this mutant displays reductions in the size of the Lmx1b/Wnt1 domain and range of canonical Wnt signaling. We posit that microRNA modulation of the Lmx1b/Wnt axis in the early midbrain/isthmus could determine midbrain size and allocation of dopamine progenitors. Since canonical Wnt activity has recently been recognized as a key

  1. LC-ESI-MS/MS method for bioanalytical determination of osteogenic phytoalexin, medicarpin, and its application to preliminary pharmacokinetic studies in rats.

    Science.gov (United States)

    Taneja, Isha; Raju, Kanumuri Siva Rama; Challagundla, Muralikrishna; Raghuvanshi, Ashutosh; Goel, Atul; Wahajuddin, Muhammad

    2015-09-15

    Medicarpin is the active phytoalexin found in the stem bark of Butea monosperma having potent osteogenic activity. An LC-ESI-MS/MS was developed and validated for quantification of medicarpin in rat plasma using liquid-liquid extraction technique and diethyl ether as the extraction solvent. Medicarpin was separated on RP18 column (4.6mm×50mm, 5.0μm) using methanol and 10mM ammonium acetate (pH 4.0) in the ratio of 80:20 (v/v) as mobile phase. The method was linear within the concentration range of 1-500ng/mL and its sensitivity was 1ng/mL. The precision value for intra- and inter-day assays and stability assays was within 0.88-14.22% while the accuracy ranged between 87.46-116.0% at all four QC levels. The validated method was successfully applied to study the preclinical pharmacokinetics of medicarpin in rats. Medicarpin showed multiple peak phenomenon upon oral administration. Its oral bioavailability was 17.43%. It was found to be a rapidly absorbed (Tmax=15min), 81.61% protein bound and pH stable compound. The present study provides important information regarding preliminary pharmacokinetics of medicarpin for its further exploration as a potential therapeutic agent.

  2. 33 CFR 116.10 - Preliminary review.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Preliminary review. 116.10... ALTERATION OF UNREASONABLY OBSTRUCTIVE BRIDGES § 116.10 Preliminary review. (a) Upon receipt of a written complaint, the District Commander will review the complaint to determine if, in the District...

  3. Preliminary rock mechanics laboratory: Investigation plan

    Energy Technology Data Exchange (ETDEWEB)

    Oschman, K.P.; Hummeldorf, R.G.; Hume, H.R.; Karakouzian, M.; Vakili, J.E.

    1987-01-01

    This document presents the rationale for rock mechanics laboratory testing (including the supporting analysis and numerical modeling) planned for the site characterization of a nuclear waste repository in salt. This plan first identifies what information is required for regulatory and design purposes, and then presents the rationale for the testing that satisfies the required information needs. A preliminary estimate of the minimum sampling requirements for rock laboratory testing during site characterization is also presented. Periodic revision of this document is planned.

  4. Regulatory activities of government: analysis of determinants

    Directory of Open Access Journals (Sweden)

    Primož Pevcin

    2006-12-01

    Full Text Available International comparisons show that large cross-country differences exist in the overall macro extent of regulation of the economy. In this context, the main purpose of the article is to investigate, why such differences exist by identifying and empirically verifying the effect of various factors that could potentially shape those differences. Empirical analysis based on the sample of 32 developed and democratic countries revealed that almost 70 % of variation in the macro extent of regulation could be explained with 7 statistically significant explanatory variables. The econometric analysis revealed that the macro extent of regulation decreases with income inequality in society, with the level of economic development, with the sizeof economy, with the share of transfer spending in GDP and with the share of government employment in labour force. On the other hand, the extent of regulation is positively related to government ownership of enterprises and to presidential political regime

  5. 75 FR 11153 - Hydro Energy Technologies, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2010-03-10

    ... Energy Regulatory Commission Hydro Energy Technologies, LLC; Notice of Preliminary Permit Application.... On November 6, 2009, Hydro Energy Technologies, LLC (Hydro Energy Technologies) filed an application...-hours. Hydro Energy Technologies: Anthony J. Marra Jr., President, Hydro Energy Technologies, LLC.,...

  6. 76 FR 1613 - Mahoning Hydropower, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2011-01-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Mahoning Hydropower, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting Comments, Motions To Intervene, and Competing Applications January 4, 2011...

  7. A unified architecture of transcriptional regulatory elements

    DEFF Research Database (Denmark)

    Andersson, Robin; Sandelin, Albin Gustav; Danko, Charles G.

    2015-01-01

    Gene expression is precisely controlled in time and space through the integration of signals that act at gene promoters and gene-distal enhancers. Classically, promoters and enhancers are considered separate classes of regulatory elements, often distinguished by histone modifications. However...... and enhancers are considered a single class of functional element, with a unified architecture for transcription initiation. The context of interacting regulatory elements and the surrounding sequences determine local transcriptional output as well as the enhancer and promoter activities of individual elements....

  8. ATMPs for Cancer Immunotherapy: A Regulatory Overview.

    Science.gov (United States)

    Galli, Maria Cristina

    2016-01-01

    This chapter discusses European regulatory requirements for development of advanced therapy medicinal products (ATMP) for cancer immunotherapy approaches, describing the framework for clinical trials and for marketing authorization.Regulatory critical issues and challenges for developing ATMP are also discussed, with focus on potency determination, long-term follow-up, comparability, and insertional mutagenesis issues. Some of the most critical features of GMP application to ATMP are also described.

  9. Regulatory guidance document

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-05-01

    The Office of Civilian Radioactive Waste Management (OCRWM) Program Management System Manual requires preparation of the OCRWM Regulatory Guidance Document (RGD) that addresses licensing, environmental compliance, and safety and health compliance. The document provides: regulatory compliance policy; guidance to OCRWM organizational elements to ensure a consistent approach when complying with regulatory requirements; strategies to achieve policy objectives; organizational responsibilities for regulatory compliance; guidance with regard to Program compliance oversight; and guidance on the contents of a project-level Regulatory Compliance Plan. The scope of the RGD includes site suitability evaluation, licensing, environmental compliance, and safety and health compliance, in accordance with the direction provided by Section 4.6.3 of the PMS Manual. Site suitability evaluation and regulatory compliance during site characterization are significant activities, particularly with regard to the YW MSA. OCRWM`s evaluation of whether the Yucca Mountain site is suitable for repository development must precede its submittal of a license application to the Nuclear Regulatory Commission (NRC). Accordingly, site suitability evaluation is discussed in Chapter 4, and the general statements of policy regarding site suitability evaluation are discussed in Section 2.1. Although much of the data and analyses may initially be similar, the licensing process is discussed separately in Chapter 5. Environmental compliance is discussed in Chapter 6. Safety and Health compliance is discussed in Chapter 7.

  10. A preliminary study for the development of reference material using oyster for determination of (137)Cs, (90)Sr and plutonium isotopes.

    Science.gov (United States)

    Lee, Sang-Han; Oh, Jung-Suk; Lee, Jong-Man; Lee, Kyung-Bum; Park, Tae-Soon; Lee, Min-Kie; Kim, Seung-Hwan; Choi, Jong-Ki

    2016-03-01

    A new reference material for the determination of (137)Cs, (90)Sr and Pu isotopes ((238)Pu and (239,240)Pu) is being developed using dried oyster matrix by Korea Research Institute of Standards and Science (KRISS). The oyster was collected from Tongyoung harbour, southern part of Korea and the artificial radionuclides ((137)Cs, (90)Sr, (238)Pu and (239,240)Pu) were spiked into the material. After pretreatment and processing, the material was tested for homogeneity and massic activities were determined by measuring (137)Cs, (90)Sr, (238)Pu and (239,240)Pu. The reference value and extended uncertainty for those isotopes will be reported later.

  11. Determination of minimum alveolar concentration of isoflurane in dogs and cats using the up-and-down method. A preliminary study.

    Science.gov (United States)

    Barletta, Michele; Quandt, Jane; Hofmeister, Erik

    2016-06-01

    Minimum alveolar concentration (MAC) is a reliable measurement of the potency of inhaled anesthetic agents. The determination of MAC in different species has followed a fairly consistent methodology. In people, MAC is determined with the up-and-down method, whereas in animal the bracketing technique is commonly used. The objectives of this study were to determine the MAC value of isoflurane in dogs and cats using the up-and-down method and to determine the MAC value of isoflurane at extubation (MACex). General anesthesia was induced in 13 dogs and 5 cats with 5% isoflurane in oxygen. An initial end-tidal isoflurane concentration of 1.3% was used for the first dog and of 1.6% for the first cat and maintained constant for ≥20min. A noxious stimulus in the form of Carmalt forceps was applied to the base of the tail for no more than one minute or until movement was noticed. After stimulation, the response was recorded as positive (movement) or negative (no movement) and the animal was recovered. The end-tidal isoflurane concentration of the following animal was increased or decreased by 0.1% if the response of the previous animal to the stimulus was negative or positive, respectively. Isoflurane MAC values in dogs were 1.27% and 1.23%. Isoflurane MAC value in cats was 1.58%. MACex value was 0.45% in dogs and in cats. The up-and-down method for MAC determination achieved similar results when compared to MAC values of isoflurane in dogs and cats reported in the literature using the bracketing technique. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. A preliminary study of the influence of ions in the pore solution of hardened cement pastes on the porosity determination by low temperature calorimetry

    DEFF Research Database (Denmark)

    Wu, Min; Johannesson, Björn; Geiker, Mette

    2014-01-01

    Thermodynamic modeling was used to predict the ionic concentrations in the pore solution of cement pastes at different temperatures during a freezing and melting measurement in low temperature calorimetry (LTC) studies. By using the predicted ionic concentrations, the temperature depressions caused...... by the ions presented in the pore solution were determined. The influence of the freezing/melting point depression caused by the ions on the determined pore size distribution by LTC was demonstrated. Thermodynamic modeling using the program PHREEQC was performed on the cylinder and powder samples of cement...... pastes prepared by two types of cements, i.e., CEM 132.5 R and CEM III/B 42.5 N. Using the modeled ionic concentrations, the calculated differential pore size distributions for the studied samples with and without considering the temperature depression caused by the ions in the pore solution were...

  13. Alaska gold rush trails study: Preliminary draft

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Preliminary study draft, with maps, of seven gold rush trails in Alaska, to determine suitability for inclusion in the National Scenic Trails system and their...

  14. Regulatory T cell memory

    Science.gov (United States)

    Rosenblum, Michael D.; Way, Sing Sing; Abbas, Abul K.

    2016-01-01

    Memory for antigen is a defining feature of adaptive immunity. Antigen-specific lymphocyte populations show an increase in number and function after antigen encounter and more rapidly re-expand upon subsequent antigen exposure. Studies of immune memory have primarily focused on effector B cells and T cells with microbial specificity, using prime challenge models of infection. However, recent work has also identified persistently expanded populations of antigen-specific regulatory T cells that protect against aberrant immune responses. In this Review, we consider the parallels between memory effector T cells and memory regulatory T cells, along with the functional implications of regulatory memory in autoimmunity, antimicrobial host defence and maternal fetal tolerance. In addition, we discuss emerging evidence for regulatory T cell memory in humans and key unanswered questions in this rapidly evolving field. PMID:26688349

  15. NRC regulatory initiatives

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, T.C. [Nuclear Regulatory Commission (United States)

    1989-11-01

    The US Nuclear Regulatory Commission (NRC) is addressing several low-level waste disposal issues that will be important to waste generators and to States and Compacts developing new disposal capacity. These issues include Greater-Than-Class C (GTCC) waste, mixed waste, below regulatory concern (BRC) waste, and the low-level waste data base. This paper discusses these issues and their current status.

  16. The Michigan regulatory incentives study for electric utilities

    Energy Technology Data Exchange (ETDEWEB)

    Reid, M.W.; Weaver, E.M. (Barakat and Chamberlin, Inc., Oakland, CA (United States))

    1991-06-17

    This is the final report of Phase I of the Michigan Regulatory Incentives Study for Electric Utilities, a three-phase review of Michigan's regulatory system and its effects on resource selection by electric utilities. The goal of Phase I is to identify and analyze financial incentive mechanisms that encourage selection of resources in accord with the principles of integrated resource planning (IRP) or least-cost planning (LCP). Subsequent study phases will involve further analysis of options and possibly a collaborative formal effort to propose regulatory changes. The Phase I analysis proceeded in three steps: (1) identification and review of existing regulatory practices that affect utilities; selection of resources, particularly DSM; (2) preliminary analysis of ten financial mechanisms, and selection of three for further study; (3) detailed analysis of the three mechanisms, including consideration of how they could be implemented in Michigan and financial modeling of their likely impacts on utilities and ratepayers.

  17. Preliminary Monthly Climatological Summaries

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Preliminary Local Climatological Data, recorded since 1970 on Weather Burean Form 1030 and then National Weather Service Form F-6. The preliminary climate data pages...

  18. 78 FR 28838 - New England Hydropower Company, LLC; Notice of Preliminary Permit Application Accepted for Filing...

    Science.gov (United States)

    2013-05-16

    ... Energy Regulatory Commission New England Hydropower Company, LLC; Notice of Preliminary Permit... April 29, 2013, the New England Hydropower Company, LLC filed an application for a preliminary permit... of Engineers. The existing Lensdale Pond Dam and appurtenant works, including an existing powerhouse...

  19. 77 FR 75630 - New England Hydropower Company, LLC; Notice of Preliminary Permit Application Accepted for Filing...

    Science.gov (United States)

    2012-12-21

    ... Federal Energy Regulatory Commission New England Hydropower Company, LLC; Notice of Preliminary Permit... December 7, 2012, the New England Hydropower Company, LLC, filed an application for a preliminary permit... Mill Dam and appurtenant works, including a former powerhouse foundation and intake structures, are...

  20. 78 FR 72668 - Goodwin Power, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Science.gov (United States)

    2013-12-03

    ... Energy Regulatory Commission Goodwin Power, LLC; Notice of Preliminary Permit Application Accepted for..., Goodwin Power, LLC filed an application for a successive preliminary permit, pursuant to section 4(f) of... the Goodwin Dam Project, located on the Stanislaus River in Tuolumne and Calaveras...

  1. 75 FR 5076 - Fred Coleman; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Science.gov (United States)

    2010-02-01

    ... Energy Regulatory Commission Fred Coleman; Notice of Preliminary Permit Application Accepted for Filing... November 13, 2009, Fred Coleman filed an application for a preliminary permit, pursuant to section 4(f) of the Federal Power Act, proposing to study the feasibility of the Coleman Ranch Hydroelectric...

  2. 76 FR 21891 - Seneca Nation of Indians; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2011-04-19

    ... Energy Regulatory Commission Seneca Nation of Indians; Notice of Preliminary Permit Application Accepted..., 2011, the Seneca Nation of Indians filed an application for a preliminary permit, pursuant to section 4... owners' express permission. The Seneca Nation of Indians proposed project would consist of the...

  3. 77 FR 48514 - Water Asset Management, Inc.; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2012-08-14

    ... Federal Energy Regulatory Commission Water Asset Management, Inc.; Notice of Preliminary Permit... June 6, 2012, Water Asset Management, Inc., New York, filed an application for a preliminary permit... Winnemucca Farms West site project.\\1\\ \\1\\ Water Asset Management, Inc. Winnemucca Farms West Pump...

  4. 77 FR 48513 - Water Asset Management, Inc.; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2012-08-14

    ... Energy Regulatory Commission Water Asset Management, Inc.; Notice of Preliminary Permit Application..., 2012, Water Asset Management, Inc., New York, filed an application for a preliminary permit, pursuant... Farms East site project.\\1\\ \\1\\ Water Asset Management, Inc., Winnemucca Farms East Pump Storage...

  5. 76 FR 23321 - New Sweden Irrigation District, ID; Notice of Preliminary Permit Application Accepted for Filing...

    Science.gov (United States)

    2011-04-26

    ... Energy Regulatory Commission New Sweden Irrigation District, ID; Notice of Preliminary Permit Application..., 2011, New Sweden Irrigation District filed an application for a preliminary permit, pursuant to section 4(f) of the Federal Power Act (FPA), proposing to study the feasibility of the New...

  6. 75 FR 49929 - Music Mountain Hydro, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2010-08-16

    ... Energy Regulatory Commission Music Mountain Hydro, LLC; Notice of Preliminary Permit Application Accepted.... On May 18, 2010, Music Mountain Hydro, LLC filed an application for a preliminary permit, pursuant to section 4(f) of the Federal Power Act, proposing to study the feasibility of the Music ] Mountain Pumped...

  7. 75 FR 22579 - Bishop Paiute Tribe; Notice of Competing Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2010-04-29

    ... Energy Regulatory Commission Bishop Paiute Tribe; Notice of Competing Preliminary Permit Application... Bishop Paiute Tribe filed an application for a preliminary permit, pursuant to section 4(f) of the Federal Power Act (FPA), proposing to study the feasibility of the Bishop Paiute Hydroelectric Project...

  8. 76 FR 24014 - Renew Hydro, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Science.gov (United States)

    2011-04-29

    ... Energy Regulatory Commission Renew Hydro, LLC; Notice of Preliminary Permit Application Accepted for..., Renew Hydro, LLC filed an application for a preliminary permit, pursuant to section 4(f) of the Federal... be 15,768,000 kilowatt-hours. Applicant Contact: John E. Marciszewski, General Manager, Renew...

  9. 75 FR 65311 - Renew Hydro, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Science.gov (United States)

    2010-10-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Renew Hydro, LLC; Notice of Preliminary Permit Application Accepted for... July 13, 2010, Renew Hydro, LLC filed an application for a preliminary permit, pursuant to section...

  10. 77 FR 13593 - AMENICO Green Solutions, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2012-03-07

    ... Federal Energy Regulatory Commission AMENICO Green Solutions, LLC; Notice of Preliminary Permit... Green Solutions, LLC filed an application for a preliminary permit, pursuant to section 4(f) of the..., Manager, AMENICO Green Solutions, LLC, 5 Main Street, Pittsfield, NH 03263; phone: (603) 228- 3611....

  11. 77 FR 41781 - City of Quincy; FFP Project 109, LLC; Notice of Competing Preliminary Permit Applications...

    Science.gov (United States)

    2012-07-16

    ... Energy Regulatory Commission City of Quincy; FFP Project 109, LLC; Notice of Competing Preliminary Permit... May 1, 2012, City of Quincy and FFP Project 109, LLC filed preliminary permit applications pursuant to...: Mr. Charles Bevelheimer, 730 Maine Street, Quincy, IL 62301; (217) 228-4500. FFP Project 109,...

  12. 77 FR 41782 - City of Quincy; FFP Project 110, LLC; Notice of Competing Preliminary Permit Applications...

    Science.gov (United States)

    2012-07-16

    ... Energy Regulatory Commission City of Quincy; FFP Project 110, LLC; Notice of Competing Preliminary Permit... May 1, 2012, City of Quincy and FFP Project 110, LLC filed preliminary permit applications pursuant to... 62301; (217) 228-4500. FFP Project 110, LLC's proposed project would consist of: (1) Fourteen new...

  13. 78 FR 2988 - New England Hydropower Company, LLC; Notice of Preliminary Permit Application Accepted for Filing...

    Science.gov (United States)

    2013-01-15

    ... Energy Regulatory Commission New England Hydropower Company, LLC; Notice of Preliminary Permit... December 28, 2012, the New England Hydropower Company, LLC, filed an application for a preliminary permit... Protection. Applicant Contact: Mr. Michael C. Kerr, New England Hydropower Company, LLC, P.O. Box 5524...

  14. 78 FR 61958 - New England Hydropower Company, LLC; Notice of Preliminary Permit Application Accepted for Filing...

    Science.gov (United States)

    2013-10-08

    ... Energy Regulatory Commission New England Hydropower Company, LLC; Notice of Preliminary Permit... August 20, 2013, the New England Hydropower Company, LLC filed an application for a preliminary permit.... Michael C. Kerr, New England Hydropower Company, LLC, P.O. Box 5524, Beverly Farms, Massachusetts 01915...

  15. 77 FR 71590 - New England Hydropower Company, LLC; Notice of Preliminary Permit Application Accepted for Filing...

    Science.gov (United States)

    2012-12-03

    ... Federal Energy Regulatory Commission New England Hydropower Company, LLC; Notice of Preliminary Permit... November 9, 2012, the New England Hydropower Company, LLC, filed an application for a preliminary permit.... Michael C. Kerr, New England Hydropower Company, LLC, P.O. Box 5524, Beverly Farms, Massachusetts 01915...

  16. 78 FR 2990 - Juneau Hydropower, Inc.; Notice of Successive Preliminary Permit Application Accepted for Filing...

    Science.gov (United States)

    2013-01-15

    ... Energy Regulatory Commission Juneau Hydropower, Inc.; Notice of Successive Preliminary Permit Application..., 2012, Juneau Hydropower, Inc., filed an application for a successive preliminary permit, pursuant to...: Duff Mitchell, Business Manager, Juneau Hydropower, Inc. P.O. Box 22775, Juneau, AK 99802; email: duff...

  17. 77 FR 31349 - Coastal Hydropower, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2012-05-25

    ... Energy Regulatory Commission Coastal Hydropower, LLC; Notice of Preliminary Permit Application Accepted..., Coastal Hydropower, LLC filed an application for a preliminary permit, pursuant to section 4(f) of the... Contact: Neil Anderson, Coastal Hydropower, LLC, Key Centre, 601 108th Avenue NE., Suite 1900, Bellevue...

  18. 78 FR 69080 - Houtama Hydropower LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2013-11-18

    ... Energy Regulatory Commission Houtama Hydropower LLC; Notice of Preliminary Permit Application Accepted..., 2013, Houtama Hydropower LLC filed an application for a preliminary permit, pursuant to section 4(f) of... Contact: Mr. William C. Hampton, CEO, Houtama Hydropower ] LLC, 1044 NW 12th Drive, Pendleton, OR 97801...

  19. 75 FR 8321 - Coastal Hydropower LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2010-02-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Project No. 13619-000 Coastal Hydropower LLC; Notice of Preliminary Permit... February 18, 2010. On November 5, 2009, Coastal Hydropower LLC filed an application for a preliminary...

  20. 78 FR 12050 - Juneau Hydropower, Inc.; Notice of Successive Preliminary Permit Application Accepted for Filing...

    Science.gov (United States)

    2013-02-21

    ... Energy Regulatory Commission Juneau Hydropower, Inc.; Notice of Successive Preliminary Permit Application..., 2012, Juneau Hydropower, Inc., filed an application for a successive preliminary permit, pursuant to...: Duff Mitchell, Business Manager, Juneau Hydropower, Inc. P.O. Box 22775, Juneau, AK 99802; email: duff...

  1. 75 FR 8320 - Coastal Hydropower LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2010-02-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Coastal Hydropower LLC; Notice of Preliminary Permit Application Accepted.... On November 5, 2009, Coastal Hydropower LLC filed an application for a preliminary permit, pursuant...

  2. 77 FR 25163 - Stoughton Water Power Company; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2012-04-27

    ... Energy Regulatory Commission Stoughton Water Power Company; Notice of Preliminary Permit Application..., 2011, the Stoughton Water Power Company filed an application for a preliminary permit under section 4(f) of the Federal Power Act proposing to study the feasibility of the proposed Stoughton Dam Water...

  3. 77 FR 14775 - Stoughton Water Power Company; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2012-03-13

    ... Energy Regulatory Commission Stoughton Water Power Company; Notice of Preliminary Permit Application..., 2011, the Stoughton Water Power Company filed an application for a preliminary permit under section 4(f) of the Federal Power Act proposing to study the feasibility of the proposed Stoughton Dam Water...

  4. 77 FR 23242 - Grand Coulee Project Hydroelectric Authority; Notice of Preliminary Permit Application Accepted...

    Science.gov (United States)

    2012-04-18

    ... the Banks Lake Pumped Storage Project (Banks Lake Project or project) to be located on Banks Lake and... Energy Regulatory Commission Grand Coulee Project Hydroelectric Authority; Notice of Preliminary Permit... December 1, 2011, the Grand Coulee Project Hydroelectric Authority filed an application for a preliminary...

  5. 77 FR 27767 - Milford Hydro, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Science.gov (United States)

    2012-05-11

    ... Energy Regulatory Commission Milford Hydro, LLC; Notice of Preliminary Permit Application Accepted for..., Milford Hydro, LLC filed an application for a preliminary permit, pursuant to section 4(f) of the Federal Power Act, proposing to study the feasibility of the Milford Dam Hydroelectric Project, which would be...

  6. 75 FR 78235 - Dodge Mill Realty, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2010-12-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Dodge Mill Realty, LLC; Notice of Preliminary Permit Application Accepted.... On December 3, 2010, Dodge Mill Realty, LLC filed an application for a preliminary permit,...

  7. 76 FR 9340 - Mill Town Power Project; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2011-02-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Mill Town Power Project; Notice of Preliminary Permit Application Accepted..., 2011, Mill Town Power Project filed an application for a preliminary permit, pursuant to section...

  8. 76 FR 67181 - Windsor Machinery Co., Inc.; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2011-10-31

    ... Energy Regulatory Commission Windsor Machinery Co., Inc.; Notice of Preliminary Permit Application..., 2011, Windsor Machinery Co., Inc. filed an application for a preliminary permit, pursuant to section 4... an annual generation of 1,600 megawatt-hours. Applicant Contact: Sarah L. Bower, Windsor Machinery...

  9. 75 FR 66079 - Bishop Tungsten Development, LLC; Notice of Preliminary Permit Application Accepted for Filing...

    Science.gov (United States)

    2010-10-27

    ... Energy Regulatory Commission Bishop Tungsten Development, LLC; Notice of Preliminary Permit Application..., 2010. On November 9, 2009, Bishop Tungsten Development, LLC filed an application for a preliminary... be 26,300,000 kilowatt-hours. Applicant Contact: Douglas A. Hicks, Bishop Tungsten Development,...

  10. Preliminary Study to Test the Feasibility of Sex Identification of Human (Homo sapiens) Bones Based on Differences in Elemental Profiles Determined by Handheld X-ray Fluorescence.

    Science.gov (United States)

    Nganvongpanit, Korakot; Buddhachat, Kittisak; Brown, Janine L; Klinhom, Sarisa; Pitakarnnop, Tanita; Mahakkanukrauh, Pasuk

    2016-09-01

    Sex assignment of human remains is a crucial step in forensic anthropological studies. The aim of this study was to examine elemental differences between male and female bones using X-ray fluorescence (XRF) and determine if elemental profiling could be used for sex discrimination. Cranium, humerus, and os coxae of 60 skeletons (30 male, 30 female) from the Chiang Mai University Skeletal Collection were scanned by XRF and differences in elemental profiles between male and female bones determined using discriminant analysis. In the cranium, three elements (S, Ca, Pb) were significantly higher in males and five elements (Si, Mn, Fe, Zn, Ag) plus light elements (atomic number lower than 12) were higher in females. In humerus and os coxae, nine elements were significantly higher in male and one element was higher in female samples. The accuracy rate for sex estimation was 60, 63, and 61 % for cranium, humerus, and os coxae, respectively, and 67 % when data for all three bones were combined. We conclude that there are sex differences in bone elemental profiles; however, the accuracy of XRF analyses for discriminating between male and female samples was low compared to standard morphometric and molecular methods. XRF could be used on small samples that cannot be sexed by traditional morphological methods, but more work is needed to increase the power of this technique for gender assignment.

  11. Simple method of determination of copper, mercury and lead in potable water with preliminary pre-concentration by total reflection X-ray fluorescence spectrometry

    Science.gov (United States)

    Hołyńska, B.; Ostachowicz, B.; Wȩgrzynek, D.

    1996-06-01

    Total reflection X-ray fluorescence spectrometry and chemical pre-concentration procedures have been applied for the analysis of trace concentrations of copper, mercury, and lead in drinking water samples. A simple total reflection module has been used in X-ray measurements. The elements under investigation were pre-concentrated by complexation using a mixture of carbamates followed by solvent extraction with methyl isobutyl ketone. The preconcentration procedure was tested with the use of twice-distilled water samples and samples of mineral and tap water spiked with known additions of copper, mercury, and lead. The obtained recovery and precision values are presented. The minimum detection limits for the determination of these elements in mineral and tap water samples were found to be 40 ng l -1, 60 ng l -1, and 60 ng l -1, respectively.

  12. Experiment to determine electrical conductivity and equation of state data from Ohmically exploded tamped planar foils - preliminary diagnostic results and modeling

    Science.gov (United States)

    Ruden, E. L.; Amdahl, D. J.; Brown, D. J.; Grabowski, T. C.; Gregg, C. W.; Kostora, M. R.; Martinez, B. M.; Parker, J. V.; Camacho, J. F.; Coffey, S. K.; Poulsen, P.

    2009-11-01

    Diagnostic results from initial nondestructive (thick foil, low current) tests are presented for an experiment to simultaneously determine the electrical conductivity, pressure, density, specific energy, and temperature time histories of a planar metal foil tamped by a well characterized transparent material and exploded by a 36 μF, 50 kV rated capacitor bank discharge. Voltage differentials measure the foil's surface electric field, a B-dot probe measures surface current density, and a laser velocity interferometer (VISAR) measures dynamic foil thickness. From such and future filtered photodiode measurements, the desired properties will be inferred up to a few eV and within an order of magnitude of solid density. The purpose of the present phase of the experiment is to develop and validate diagnostic designs, data analysis techniques, and 2-D MHD simulations of the process using the MACH2 code.

  13. Determination of drugs in surface water and wastewater samples by liquid chromatography-mass spectrometry: Methods and preliminary results including toxicity studies with Vibrio fischeri

    Science.gov (United States)

    Farre, M.; Ferrer, I.; Ginebreda, A.; Figueras, M.; Olivella, L.; Tirapu, L.; Vilanova, M.; Barcelo, D.

    2001-01-01

    In the present work a combined analytical method involving toxicity and liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) was developed for the determination of pharmaceutical compounds in water samples. The drugs investigated were the analgesics: ibuprofen, ketoprofen, naproxen, and diclofenac, the decomposition product of the acetyl salicylic acid: salicylic acid and one lipid lowering agent, gemfibrozil. The selected compounds are acidic substances, very polar and all of them are analgesic compounds that can be purchased without medical prescription. The developed protocol consisted, first of all, on the use Microtox?? and ToxAlert??100 toxicity tests with Vibrio fischeri for the different pharmaceutical drugs. The 50% effective concentration (EC50) values and the toxicity units (TU) were determined for every compound using both systems. Sample enrichment of water samples was achieved by solid-phase extraction procedure (SPE), using the Merck LiChrolut?? EN cartridges followed by LC-ESI-MS. Average recoveries loading 1 l of samples with pH=2 varied from 69 to 91% and the detection limits in the range of 15-56 ng/l. The developed method was applied to real samples from wastewater and surface-river waters of Catalonia (north-east of Spain). One batch of samples was analyzed in parallel also by High Resolution Gas Chromatography coupled with Mass Spectrometry (HRGC-MS) and the results have been compared with the LC-ESI-MS method developed in this work. ?? 2001 Elsevier Science B.V. All rights reserved.

  14. Determination of fruit origin by using 26S rDNA fingerprinting of yeast communities by PCR-DGGE: preliminary application to Physalis fruits from Egypt.

    Science.gov (United States)

    El Sheikha, Aly Farag; Condur, Ana; Métayer, Isabelle; Nguyen, Doan Duy Le; Loiseau, Gérard; Montet, Didier

    2009-10-01

    The determination of geographical origin is a demand of the traceability system of import-export food products. One hypothesis for tracing the source of a product is by global analysis of the microbial communities of the food and statistical linkage of this analysis to the geographical origin of the food. For this purpose, a molecular technique employing 26S rDNA profiles generated by PCR-DGGE was used to detect the variation in yeast community structures of three species of Physalis fruit (Physalis ixocarpa Brat, Physalis pubescens L, Physalis pruinosa L) from four Egyptian regions (Qalyoubia, Minufiya, Beheira and Alexandria Governments). When the 26S rDNA profiles were analysed by multivariate analysis, distinct microbial communities were detected. The band profiles of Physalis yeasts from different Governments were specific for each location and could be used as a bar code to discriminate the origin of the fruits. This method is a new traceability tool which provides fruit products with a unique biological bar code and makes it possible to trace back the fruits to their original location.

  15. Expression and purification of a natural N-terminal pre-ligand assembly domain of tumor necrosis factor receptor 1 (TNFR1 PLAD) and preliminary activity determination.

    Science.gov (United States)

    Cao, Jin; Meng, Fang; Gao, Xiangdong; Dong, Hongxia; Yao, Wenbing

    2011-04-01

    A domain at the NH(2) terminal (N-terminal) of tumor necrosis factor receptor (TNFR) termed the pre-ligand binding assembly domain (PLAD). The finding that PLAD can mediate a selective TNFR assembly in previously researches provides a novel target to the prevention of TNFR signaling in immune-mediated inflammatory diseases (IMID). In this study, a natural N-terminal TNFR1 PLAD was obtained for the first time through the methods of GST-tag fusion protein expression and enterokinase cleavage. After purification with a Q Sepharose Fast Flow column, a natural N-terminal TNFR1 PLAD which purity was up to 95%, was obtained and was identified using Nano LC-ECI-MS/MS. Secondary structure analysis of PLAD was carried out using circular dichroism spectra (CD). After that, the TNFR1 PLAD in vitro anti-TNFα activity and the specific TNFR1 affinity were determined. The results proved that the natural N-terminal TNFR1 PLAD can selectively inhibit TNFα bioactivity mainly through TNFR1. It infers an effective and safe strategy for treating variety of IMID with a low risk of side effects in future.

  16. Determinações preliminares do teor de óleo essencial em camomila cultivada no Brasil Preliminary determination of essential oil content in camomile growing in Brasil

    Directory of Open Access Journals (Sweden)

    Mario Guilherme Roberto Donalisio

    1985-01-01

    Full Text Available Amostras de capítulos florais, pedúnculos florais e caules de camomila cultivada no Brasil foram destiladas em aparelho destilador de Clevenger para avaliação dos respectivos teores de óleo essencial, sendo encontrados os seguintes valores médios por material destilado: capítulos florais: 0,421%; pedúnculos florais: 0,132% e caules:0,0251 %. Os valores percentuais de óleo essencial relativos a capítulos florais são comparáveis aos encontrados em camomila produzida em diversos países produtores tradicionais: Alemanha: 0,5%; França: 0,5%; Hungria: 0,4%; Áustria: 0,4%; Grécia: 0,4% e Espanha: 0,3%, e satisfazem as exigências mínimas da farmacopéia brasileira: 0,4%.Trading samples of Matricaria camomilla L. growing in Brazil were analised totally and in their parts (flower, peduncule and stalk to determine their essencial oil content. The distillation procedure followed the Clevenger method. The average essencial oil content of brazilian camomile flowers was 0.421%, which is similar to the oil content of camomile flowers from several other tradicional regions, and it is above the minimum level required by the Brazilian Pharmacopoeia (0.4%.

  17. Study on the Status and the Determinants of the Satisfaction about Food Safety Regulato-ry among the Public%公众食品安全监管满意现状及影响因素分析

    Institute of Scientific and Technical Information of China (English)

    李宇阳; 蒋凌琳; 秦秋艳

    2014-01-01

    目的:了解公众对食品安全监管的满意现状及其影响因素。方法采用多阶段分层随机抽样方法,对浙江省7550名常住人口进行问卷调查。结果有效问卷7460份,有效回收率为98.81%。公众最担心肉制品类和违规使用添加剂的安全隐患,最常遇到食品过期变质问题。公众对监管现状和监管工作满意度受到了无证无照现象认知、宣传工作力度、打击违法行为力度、投诉举报畅通程度、性别和文化程度6个共同因素影响,监管现状满意度还受到了居住地、职业和不安全食品经历其他3个因素影响。结论公众对食品安全监管的评价不容乐观,应不断加大食品安全监管力度,加强城郊结合部的治理工作,从根本上减少和杜绝不安全食品,增强公众对食品安全的信心和安全感。%Objectives To investigate the status and the determinants of the satisfaction about food safety regulation among the public.Methods Multi-stage stratified random sampling method was used to select 7 550 permanent population in Zhejiang province to carry out the questionnaire survey.Results A total of 7 460 valid questionnaires were responded,the ef-fective rate was 98.81%.The most worried food type and food safety hazard was meat and illegal use of additives respectively. The most frequently encountered problem was food expired metamorphic.The common six influencing factors about consumer satisfaction of food safety regulatory status quo and supervision were unlicensed phenomenon cognitive,food safety propaganda work dynamics,strength of food illegal behavior,unblocked degree of complaints,sex and education degree.The satisfaction with food safety regulatory status quo also was affected by residence,occupation and unsafe food experience.Conclusions The evaluation to-wards food safety regulation is not optimistic,and food safety regulation should be strengthened to preferably govern suburban districts

  18. Determination of ANA specificity using multiplexed fluorescent microsphere immunoassay in patients with ANA positivity at high titres after infliximab treatment: preliminary results.

    Science.gov (United States)

    Caramaschi, Paola; Ruzzenente, Orazio; Pieropan, Sara; Volpe, Alessandro; Carletto, Antonio; Bambara, Lisa Maria; Biasi, Domenico

    2007-05-01

    To evaluate ANA specificity using the fully automated multiplexed fluorescent microsphere immunoassay in patients affected either by rheumatoid arthritis or ankylosing spondylitis who developed strong positivity for ANA as assessed by indirect immunofluorescent method on HEp-2 cells during infliximab treatment. Three men affected by ankylosing spondylitis and 12 women affected by rheumatoid arthritis who developed ANA positivity at high titres during infliximab treatment underwent the identification of ANA specificity by multiplexed fluorescent microsphere immunoassay; moreover anti-DNA and anti-ENA antibodies were tested by indirect immunofluorescence and ELISA method, respectively. In 4 out of 15 cases, the determination of ANA reactivity by multiplexed fluorescent microsphere immunoassay was also performed on the serum collected before infliximab administration. One patient affected by rheumatoid arthritis showed multiple ANA reactivities against SS-A, SS-B, RNP, Sm, Jo-1 and histones; one patient affected by ankylosing spondylitis resulted positive for the same autoantibodies, except for anti-Sm antibody. Moreover, two patients, one with rheumatoid arthritis and one with ankylosing spondylitis, showed single antibody specificity to SS-B and RNP, respectively. The remaining 11 cases did not show any positivity. Instead, all the patients resulted negative for anti-ENA antibodies by the ELISA method. In the four cases tested for ANA specificity by multiplexed fluorescent microsphere immunoassay before and after infliximab administration no difference was found. The search for anti-DNA antibody always resulted negative by both the traditional immunofluorescent assay and the novel technique. The use of multiplexed fluorescent microsphere immunoassay in patients treated with infliximab with ANA positivity at high titres allowed to find some ANA specificities which were not revealed by ELISA method. Nevertheless, the majority of patients resulted negative in spite of

  19. Cis-regulatory mutations in human disease.

    Science.gov (United States)

    Epstein, Douglas J

    2009-07-01

    Cis-acting regulatory sequences are required for the proper temporal and spatial control of gene expression. Variation in gene expression is highly heritable and a significant determinant of human disease susceptibility. The diversity of human genetic diseases attributed, in whole or in part, to mutations in non-coding regulatory sequences is on the rise. Improvements in genome-wide methods of associating genetic variation with human disease and predicting DNA with cis-regulatory potential are two of the major reasons for these recent advances. This review will highlight select examples from the literature that have successfully integrated genetic and genomic approaches to uncover the molecular basis by which cis-regulatory mutations alter gene expression and contribute to human disease. The fine mapping of disease-causing variants has led to the discovery of novel cis-acting regulatory elements that, in some instances, are located as far away as 1.5 Mb from the target gene. In other cases, the prior knowledge of the regulatory landscape surrounding the gene of interest aided in the selection of enhancers for mutation screening. The success of these studies should provide a framework for following up on the large number of genome-wide association studies that have identified common variants in non-coding regions of the genome that associate with increased risk of human diseases including, diabetes, autism, Crohn's, colorectal cancer, and asthma, to name a few.

  20. Preliminary Results of Stress Measurement Using Drill Cores of TCDP Hole-A: an Application of Anelastic Strain Recovery Method to Three-Dimensional In-Situ Stress Determination

    Directory of Open Access Journals (Sweden)

    Weiren Lin En-Chao Yeh1

    2007-01-01

    Full Text Available In order to understand the feature of rock stress change at different depths above, within, and beneath the Chelungpu fault after the Chi-Chi earthquake, we employed a core-based stress measurement method, anelastic strain recovery (ASR technique to determine both the orientations and magnitudes of present three-dimensional principal rock stresses using drill core samples retrieved from Taiwan Chelungpu-fault Drilling Project (TCDP main Hole-A. The core samples used were taken from three depths; and their lithology were sandstone at depths of 592 and 1755 m and siltstone at 1112 m. The anelastic strains of the specimens in nine directions, including six independent directions, were measured after its in-situ stress was released. Acquired anelastic strains were of high quality and reached several hundred microstrains, which is sufficiently high for the accuracy of the measurement system used. Thus, the strain data could be used for three dimensional analysis resulting in the determination of orientations and the estimation of magnitudes of the principal in-situ stresses. Preliminary stress measurement results showed that the orientations of principal stresses changed between the shallower depth above the fault and the deeper depth beneath it, that is, the present stress distribution in the TCDP hole might be influenced by the Chelungpu fault rupture. At the same time, anelastic strain recovery measurement is well suited for the task of directly determining the orientations of principal in-situ stresses and to estimate the magnitude of stresses at large/great depth.

  1. Rupture Geometry and Slip Associated With the 2007 November 14 Mw = 7.7 Tocopilla (Chile) Earthquake, as Preliminary Determined by InSAR and GPS Observations

    Science.gov (United States)

    Béjar-Pizarro, M.; Carrizo, D.; Socquet, A.; Armijo, R.; de Chabalier, J. B.; Nercessian, A.; Charade, O.; Ruegg, J. C.; Barrientos, S.; Campos, J.

    2008-05-01

    A Mw 7.7 subduction earthquake occurred on November 14, 2007 in Tocopilla (northern Chile). This region (between 16.5°S and 23.5°S) had been identified as major seismic gap (~1000 km length) that had not ruptured since the occurrence of the South Peru (Mw = 9.1, 16 August 1868) and the Iquique (Mw = 9.0, 10 May 1877) megathrust earthquakes. This gap was reduced to a length of ~500 km after the occurrence of the Arequipa (Mw = 8.3, 23 June 2001) and the Antofagasta (Mw = 8.1, 30 July 1995) earthquakes. The Tocopilla earthquake occurred within a network of continuous GPS stations operated by IPGP, Caltech, DGF and IRD. An array of 21 benchmarks, installed and previously measured periodically by IPGP/DGF, was resurveyed after the earthquake, increasing the spatial density of static observations of the surface displacement. We combine space geodesy (InSAR and GPS) data of surface displacement to determine the geometry and kinematics of the rupture on the subduction interface. The deformation pattern in the interferogram constrains the E-W extension of the fault plane. Comparison of the InSAR data of the 2007 Tocopilla and 1995 Antofagasta earthquakes documents clearly the shift in rupture depth between the two events. The Tocopilla rupture apparently extended between 50- 55 and 30-35 km depth and did not propagate up to the surface. Interestingly, the earthquake definitely ruptured the deeper part of the seismogenic interface, well into the transition zone that was identified earlier (Chlieh et al., 2004). Most of the aftershocks following the 2007 event were concentrated near the southern end of the rupture that is clearly defined by the GPS and InSAR data to the north of the Mejillones Peninsula. The region of the subduction zone under the Mejillones Peninsula appears to act as a barrier arresting rupture of large earthquakes (1877, 1995 and 2007 earthquakes). When exploring the details of the rupture on the subduction interface, geodetic data require two distinct

  2. Rationales for regulatory activity

    Energy Technology Data Exchange (ETDEWEB)

    Perhac, R.M. [Univ. of Tennessee, Knoxville, TN (United States)

    1997-02-01

    The author provides an outline which touches on the types of concerns about risk evaluation which are addressed in the process of establishing regulatory guides. Broadly he says regulatory activity serves three broad constituents: (1) Paternalism (private risk); (2) Promotion of social welfare (public risks); (3) Protection of individual rights (public risks). He then discusses some of the major issues encountered in reaching a decision on what is an acceptable level of risk within each of these areas, and how one establishes such a level.

  3. Regulatory principles governing Salmonella and Yersinia virulence

    Science.gov (United States)

    Erhardt, Marc; Dersch, Petra

    2015-01-01

    Enteric pathogens such as Salmonella and Yersinia evolved numerous strategies to survive and proliferate in different environmental reservoirs and mammalian hosts. Deciphering common and pathogen-specific principles for how these bacteria adjust and coordinate spatiotemporal expression of virulence determinants, stress adaptation, and metabolic functions is fundamental to understand microbial pathogenesis. In order to manage sudden environmental changes, attacks by the host immune systems and microbial competition, the pathogens employ a plethora of transcriptional and post-transcriptional control elements, including transcription factors, sensory and regulatory RNAs, RNAses, and proteases, to fine-tune and control complex gene regulatory networks. Many of the contributing global regulators and the molecular mechanisms of regulation are frequently conserved between Yersinia and Salmonella. However, the interplay, arrangement, and composition of the control elements vary between these closely related enteric pathogens, which generate phenotypic differences leading to distinct pathogenic properties. In this overview we present common and different regulatory networks used by Salmonella and Yersinia to coordinate the expression of crucial motility, cell adhesion and invasion determinants, immune defense strategies, and metabolic adaptation processes. We highlight evolutionary changes of the gene regulatory circuits that result in different properties of the regulatory elements and how this influences the overall outcome of the infection process. PMID:26441883

  4. Prediction of regulatory elements

    DEFF Research Database (Denmark)

    Sandelin, Albin

    2008-01-01

    Finding the regulatory mechanisms responsible for gene expression remains one of the most important challenges for biomedical research. A major focus in cellular biology is to find functional transcription factor binding sites (TFBS) responsible for the regulation of a downstream gene. As wet-lab...

  5. 76 FR 48853 - FFP Project 70, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Science.gov (United States)

    2011-08-09

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF ENERGY Federal Energy Regulatory Commission FFP Project 70, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting Comments, Motions To Intervene, and Competing Applications On May...

  6. 75 FR 79843 - Fall 2010 Regulatory Agenda

    Science.gov (United States)

    2010-12-20

    ... see our FY 2011 Regulatory Plan. 1. Taking Action on Climate Change: In 2009 EPA finalized an... Supplemental Determinations for Renewable Fuels Produced Under the Final RFS2 Program 2060-AQ36 From Palm Oil... RENEWABLE FUELS PRODUCED UNDER THE FINAL RFS2 PROGRAM FROM PALM OIL Legal Authority: Clean Air Act sec...

  7. 76 FR 37996 - West Virginia Regulatory Program

    Science.gov (United States)

    2011-06-29

    ... significant economic impact on a substantial number of small entities under the Regulatory Flexibility Act (5... making the determination as to whether this rule would have a significant economic impact, the Department... Virginia is amending its Code of State Regulations (CSR) to provide for the establishment of a minimum...

  8. Nuclear Regulatory Commission information digest

    Energy Technology Data Exchange (ETDEWEB)

    None,

    1990-03-01

    The Nuclear Regulatory Commission information digest provides summary information regarding the US Nuclear Regulatory Commission, its regulatory responsibilities, and areas licensed by the commission. This is an annual publication for the general use of the NRC Staff and is available to the public. The digest is divided into two parts: the first presents an overview of the US Nuclear Regulatory Commission and the second provides data on NRC commercial nuclear reactor licensees and commercial nuclear power reactors worldwide.

  9. Preliminary safety analysis methodology for the SMART

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Kyoo Hwan; Chung, Y. J.; Kim, H. C.; Sim, S. K.; Lee, W. J.; Chung, B. D.; Song, J. H. [Korea Atomic Energy Research Institute, Taejeon (Korea)

    2000-03-01

    This technical report was prepared for a preliminary safety analysis methodology of the 330MWt SMART (System-integrated Modular Advanced ReacTor) which has been developed by Korea Atomic Energy Research Institute (KAERI) and funded by the Ministry of Science and Technology (MOST) since July 1996. This preliminary safety analysis methodology has been used to identify an envelope for the safety of the SMART conceptual design. As the SMART design evolves, further validated final safety analysis methodology will be developed. Current licensing safety analysis methodology of the Westinghouse and KSNPP PWRs operating and under development in Korea as well as the Russian licensing safety analysis methodology for the integral reactors have been reviewed and compared to develop the preliminary SMART safety analysis methodology. SMART design characteristics and safety systems have been reviewed against licensing practices of the PWRs operating or KNGR (Korean Next Generation Reactor) under construction in Korea. Detailed safety analysis methodology has been developed for the potential SMART limiting events of main steam line break, main feedwater pipe break, loss of reactor coolant flow, CEA withdrawal, primary to secondary pipe break and the small break loss of coolant accident. SMART preliminary safety analysis methodology will be further developed and validated in parallel with the safety analysis codes as the SMART design further evolves. Validated safety analysis methodology will be submitted to MOST as a Topical Report for a review of the SMART licensing safety analysis methodology. Thus, it is recommended for the nuclear regulatory authority to establish regulatory guides and criteria for the integral reactor. 22 refs., 18 figs., 16 tabs. (Author)

  10. Hastening the regulatory process

    Energy Technology Data Exchange (ETDEWEB)

    Stringham, G. [Canadian Association of Petroleum Producers, Calgary, AB (Canada)

    2001-07-01

    The state of the Canadian oil industry was discussed during this power point presentation with particular emphasis on its production, exports, drilling, industry revenues and capital investment levels. The proposed projects in each of northern Alberta's oil sands deposits, the Athabasca, Peace River and Cold Lake were were announced, along with the inventory of major Alberta projects and the projection of oil sands capital investment. Since 1998, $9 billion has been invested and a further $33 billion has been announced for new or expanded oil sands projects. The year 2000 estimates for Canadian crude oil and natural gas production are 2.3 million barrels per day and 6.3 trillion cubic feet per year respectively. This represented a record year for production of both crude oil and natural gas. In 2000, more than 15,500 wells were drilled in Canada. A graph depicting Canadian crude oil supply forecasted a steady increase in supply from year 2000 to 2010. The Canadian Association of Petroleum Producers (CAPP) completed a review of the Alberta Energy and Utilities Board regulatory and enforcement processes. Both industry and government efforts are focusing on eliminating regulatory overlap and duplication. Some of the main areas of interest for exploration, drilling, production and pipeline facilities include the examination of regulatory processes for environmentally sensitive areas, rural municipalities with planning bylaws, aboriginal lands and additional fees. 8 figs.

  11. Statistical significance of cis-regulatory modules

    Directory of Open Access Journals (Sweden)

    Smith Andrew D

    2007-01-01

    Full Text Available Abstract Background It is becoming increasingly important for researchers to be able to scan through large genomic regions for transcription factor binding sites or clusters of binding sites forming cis-regulatory modules. Correspondingly, there has been a push to develop algorithms for the rapid detection and assessment of cis-regulatory modules. While various algorithms for this purpose have been introduced, most are not well suited for rapid, genome scale scanning. Results We introduce methods designed for the detection and statistical evaluation of cis-regulatory modules, modeled as either clusters of individual binding sites or as combinations of sites with constrained organization. In order to determine the statistical significance of module sites, we first need a method to determine the statistical significance of single transcription factor binding site matches. We introduce a straightforward method of estimating the statistical significance of single site matches using a database of known promoters to produce data structures that can be used to estimate p-values for binding site matches. We next introduce a technique to calculate the statistical significance of the arrangement of binding sites within a module using a max-gap model. If the module scanned for has defined organizational parameters, the probability of the module is corrected to account for organizational constraints. The statistical significance of single site matches and the architecture of sites within the module can be combined to provide an overall estimation of statistical significance of cis-regulatory module sites. Conclusion The methods introduced in this paper allow for the detection and statistical evaluation of single transcription factor binding sites and cis-regulatory modules. The features described are implemented in the Search Tool for Occurrences of Regulatory Motifs (STORM and MODSTORM software.

  12. Crystallization and preliminary crystallographic analysis of recombinant human galectin-1

    Energy Technology Data Exchange (ETDEWEB)

    Scott, Stacy A. [Institute for Glycomics, Gold Coast Campus, Griffith University, Queensland 4222 (Australia); Scott, Ken [School of Biological Sciences, University of Auckland, Auckland (New Zealand); Blanchard, Helen, E-mail: h.blanchard@griffith.edu.au [Institute for Glycomics, Gold Coast Campus, Griffith University, Queensland 4222 (Australia)

    2007-11-01

    Human galectin-1 has been cloned, expressed in E. coli, purified and crystallized in the presence of both lactose (ligand) and β-mercaptoethanol under six different conditions. The X-ray diffraction data obtained have enabled the assignment of unit-cell parameters for two novel crystal forms of human galectin-1. Galectin-1 is considered to be a regulator protein as it is ubiquitously expressed throughout the adult body and is responsible for a broad range of cellular regulatory functions. Interest in galectin-1 from a drug-design perspective is founded on evidence of its overexpression by many cancers and its immunomodulatory properties. The development of galectin-1-specific inhibitors is a rational approach to the fight against cancer because although galectin-1 induces a plethora of effects, null mice appear normal. X-ray crystallographic structure determination will aid the structure-based design of galectin-1 inhibitors. Here, the crystallization and preliminary diffraction analysis of human galectin-1 crystals generated under six different conditions is reported. X-ray diffraction data enabled the assignment of unit-cell parameters for crystals grown under two conditions, one belongs to a tetragonal crystal system and the other was determined as monoclinic P2{sub 1}, representing two new crystal forms of human galectin-1.

  13. 75 FR 53963 - Iron Mask Hydro, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Science.gov (United States)

    2010-09-02

    ... Federal Energy Regulatory Commission Iron Mask Hydro, LLC; Notice of Preliminary Permit Application..., 2010. On May 6, 2010, Iron Mask Hydro, LLC filed an application for a preliminary permit, pursuant to section 4(f) of the Federal Power Act (FPA), proposing to study the feasibility of the Iron Mask...

  14. 75 FR 56093 - FFP Mass 1, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Science.gov (United States)

    2010-09-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission FFP Mass 1, LLC; Notice of Preliminary Permit Application Accepted for... August 9, 2010, FFP Mass 1, LLC filed an application for a preliminary permit, pursuant to section...

  15. 77 FR 60420 - FFP Project 66 LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Science.gov (United States)

    2012-10-03

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission FFP Project 66 LLC; Notice of Preliminary Permit Application Accepted for..., FFP Project 66, LLC filed an application for a preliminary permit, pursuant to section 4(f) of...

  16. 77 FR 60421 - FFP Project 67 LLC; Notice of Preliminary Permit Application Accepted For Filing and Soliciting...

    Science.gov (United States)

    2012-10-03

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF ENERGY Federal Energy Regulatory Commission FFP Project 67 LLC; Notice of Preliminary Permit Application Accepted..., 2012, FFP Project 67, LLC filed an application for a preliminary permit, pursuant to section 4(f)...

  17. 77 FR 60423 - FFP Project 71 LLC; Notice of Preliminary Permit Application Accepted For Filing and Soliciting...

    Science.gov (United States)

    2012-10-03

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF ENERGY Federal Energy Regulatory Commission FFP Project 71 LLC; Notice of Preliminary Permit Application Accepted..., 2012, FFP Project 71, LLC filed an application for a preliminary permit, pursuant to section 4(f)...

  18. 77 FR 60421 - FFP Project 68 LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Science.gov (United States)

    2012-10-03

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission FFP Project 68 LLC; Notice of Preliminary Permit Application Accepted for..., FFP Project 68, LLC filed an application for a preliminary permit, pursuant to section 4(f) of...

  19. 77 FR 20382 - FFP Project 108, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Science.gov (United States)

    2012-04-04

    ... Energy Regulatory Commission FFP Project 108, LLC; Notice of Preliminary Permit Application Accepted for..., FFP Project 108, LLC, filed an application for a preliminary permit, pursuant to section 4(f) of the... mode as directed by the Corps. Applicant Contact: Ms. Ramya Swaminathan, FFP Project 108, LLC,...

  20. 77 FR 60423 - FFP Project 72 LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Science.gov (United States)

    2012-10-03

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission FFP Project 72 LLC; Notice of Preliminary Permit Application Accepted for..., FFP Project 72, LLC filed an application for a preliminary permit, pursuant to section 4(f) of...

  1. 77 FR 60422 - FFP Project 63 LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Science.gov (United States)

    2012-10-03

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF ENERGY Federal Energy Regulatory Commission FFP Project 63 LLC; Notice of Preliminary Permit Application Accepted..., 2012, FFP Project 63, LLC filed an application for a preliminary permit, pursuant to section 4(f)...

  2. 77 FR 60422 - FFP Project 69 LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Science.gov (United States)

    2012-10-03

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission FFP Project 69 LLC; Notice of Preliminary Permit Application Accepted for..., FFP Project 69, LLC filed an application for a preliminary permit, pursuant to section 4(f) of...

  3. 77 FR 7143 - Green Wave Mendocino Wave Park; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2012-02-10

    ... Federal Energy Regulatory Commission Green Wave Mendocino Wave Park; Notice of Preliminary Permit... September 23, 2011, Green Wave Energy Solutions, LLC, California, filed an application for a preliminary... the Green Wave Mendocino Wave Park (Mendocino Wave Project or project) to be located in the...

  4. 78 FR 58301 - Go With the Flow Hydro Power, LLC; Notice of Preliminary Permit Application Accepted for Filing...

    Science.gov (United States)

    2013-09-23

    ... Energy Regulatory Commission Go With the Flow Hydro Power, LLC; Notice of Preliminary Permit Application..., 2013, Go with the Flow Hydro Power, LLC, filed an application for a preliminary permit, pursuant to section 4(f) of the Federal Power Act (FPA), proposing to study the feasibility of the Go with the Flow...

  5. 77 FR 59608 - Go Green Go Hydro LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2012-09-28

    ... Energy Regulatory Commission Go Green Go Hydro LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting Comments, Motions To Intervene, and Competing Applications On June 20, 2012, Go Green Go Hydro LLC (Go Green or applicant) filed an application for a preliminary permit, pursuant to...

  6. 76 FR 65719 - Wyco Power and Water, Inc.; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2011-10-24

    ... Energy Regulatory Commission Wyco Power and Water, Inc.; Notice of Preliminary Permit Application... 1, 2011, Wyco Power and Water, Inc. filed an application for a preliminary permit, pursuant to... Power and Water, Inc., 1436 West Oak, Fort Collins, CO 80521, phone (970) 215-2603. FERC Contact:...

  7. 76 FR 10578 - Cuffs Run Pumped Storage, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2011-02-25

    ... Energy Regulatory Commission Cuffs Run Pumped Storage, LLC; Notice of Preliminary Permit Application... 18, 2010, Cuffs Run Pumped Storage, LLC filed an application for a preliminary permit, pursuant to section 4(f) of the Federal Power Act, proposing to study the feasibility of the Cuffs Run Pumped...

  8. 76 FR 30936 - West Maui Pumped Storage Water Supply, LLC; Notice of Preliminary Permit Application Accepted for...

    Science.gov (United States)

    2011-05-27

    ... Energy Regulatory Commission West Maui Pumped Storage Water Supply, LLC; Notice of Preliminary Permit... April 1, 2011, West Maui Pumped Storage Water Supply, LLC, filed an application for a preliminary permit... supply project effluent water to an existing irrigation system; (5) a powerhouse with two...

  9. Towards Legal Knowledge Management Systems for Regulatory Compliance

    NARCIS (Netherlands)

    Boella, G.; Hulstijn, J.; Humphreys, L.; Janssen, M.F.W.H.A.; Van der Torre, L.

    2012-01-01

    Maintaining regulatory compliance is an increasing concern. Legal Knowledge Management systems could support the work of compliance managers. However, there are challenges to overcome, of interpreting legal knowledge and mapping it onto business processes. In this discussion paper we determine

  10. Politically Induced Regulatory Risk and Independent Regulatory Agencies

    OpenAIRE

    Strausz, Roland

    2015-01-01

    Uncertainty in election outcomes generates politically induced regulatory risk. Political parties' risk attitudes towards such risk depend on a fluctuation effect that hurts both parties and an output--expansion effect that benefits at least one party. Notwithstanding the parties' risk attitudes, political parties have incentives to negotiate away all regulatory risk by pre-electoral bargaining. Efficient pre-electoral bargaining outcomes fully eliminate politically induced regulatory risk. P...

  11. Clinical research: regulatory issues.

    Science.gov (United States)

    Wermeling, D P

    1999-02-01

    The regulatory issues faced by institutions performing clinical research are described. Many institutions do not have on staff an expert who understands the regulatory issues involved in managing investigational new drug research and who knows the institution's obligations under the federal rules. Because pharmacists understand the FDA regulations that apply to the management of drugs in clinical research, institutions are asking pharmacists to expand their role and manage clinical research offices. Many authorities govern various aspects of investigational drug research. FDA has published regulations for good clinical practice (GCP), and the International Conference on Harmonisation is developing an international standard for the proper management of clinical trials. The guidelines published by the Joint Commission on Accreditation of Healthcare Organizations aim to protect patients who are in the institution to receive health care and also participate in clinical trials. The Social Security Administration Acts specifically state that only items and services that are reasonable and necessary for the diagnosis and treatment of injury or disease can be billed to the government; research-related billings are excluded from coverage. Proper management of drug research is crucial to the success of a research program that is integrated with patient care.

  12. Toxicogenomics in regulatory ecotoxicology

    Science.gov (United States)

    Ankley, Gerald T.; Daston, George P.; Degitz, Sigmund J.; Denslow, Nancy D.; Hoke, Robert A.; Kennedy, Sean W.; Miracle, Ann L.; Perkins, Edward J.; Snape, Jason; Tillitt, Donald E.; Tyler, Charles R.; Versteeg, Donald

    2006-01-01

    Recently, we have witnessed an explosion of different genomic approaches that, through a combination of advanced biological, instrumental, and bioinformatic techniques, can yield a previously unparalleled amount of data concerning the molecular and biochemical status of organisms. Fueled partially by large, well-publicized efforts such as the Human Genome Project, genomic research has become a rapidly growing topical area in multiple biological disciplines. Since 1999, when the term “toxicogenomics” was coined to describe the application of genomics to toxicology (1), a rapid increase in publications on the topic has occurred (Figure 1). The potential utility of toxicogenomics in toxicological research and regulatory activities has been the subject of scientific discussions and, as with any new technology, has evoked a wide range of opinion (2–6). VIEWPOINT © 2006 american chemical Society july 1, 2006 / EnvironmEntal SciEncE & tEchnology n 4055 The purpose of this feature article is to consider the roles of toxicogenomics in the field of regulatory ecotoxicology, explore current limitations in the science and practice of genomics, and propose possible avenues to approach and resolve some of the major challenges. A significant amount of input to our analysis came from a workshop sponsored by the Society of Environmental Toxicology and Chemistry (SETAC) in Pellston, Mich., in September 2005. A complete list of names and affiliations of the experts participating in that workshop is provided online in Table 1 of the Supporting Information for this paper.

  13. 2016 TRI Preliminary Dataset

    Science.gov (United States)

    The TRI preliminary dataset includes the most current TRI data available and reflects toxic chemical releases and pollution prevention activities that occurred at TRI facilities during the 2016 calendar year.

  14. Preliminary design of pseudo satellites: Basic methods and feasibility criteria

    Science.gov (United States)

    Klimenko, N. N.

    2016-12-01

    Analytical models of weight and energy balances, aerodynamic models, and solar irradiance models to perform pseudo-satellite preliminary design are presented. Feasibility criteria are determined in accordance with the aim of preliminary design dependent on mission scenario and type of payload.

  15. Regulatory mark; Marco regulatorio

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-10-15

    This chapter is based on a work performed in distinct phases. The first phase consisted in of the analysis regulatory legislation existent in Brazil for the sugar-alcohol sector since the beginning of the X X century. This analysis allowed the identification of non existent points and legal devices related to the studied aspects, and that were considered as problematic for the sector expansion. In the second phase, related treaties and international agreements was studied and possible obstacles for the brazilian bio ethanol exportation for the international market. Initiatives were examined at European Union, United States of America, Caribbean and countries of the sub-Saharan Africa. In this phase, policies were identified related to the incentives and adoption of use of bio fuels added to the gasoline in countries or group of countries considered as key for the consolidation of bio ethanol as a world commodity.

  16. 75 FR 54210 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of...

    Science.gov (United States)

    2010-09-03

    ...-2010-032] Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of... Transactions August 30, 2010. On June 17, 2010, the Financial Industry Regulatory Authority, Inc....

  17. 25 CFR 11.1005 - Preliminary inquiry.

    Science.gov (United States)

    2010-04-01

    ... ORDER CODE Juvenile Offender Procedure § 11.1005 Preliminary inquiry. (a) If a minor is placed in... purpose of determining: (1) Whether probable cause exist to believe the minor committed the alleged.... (b) If a minor has been released to the parents, guardian or custodian, the children's court shall...

  18. Regulatory focus in groupt contexts

    NARCIS (Netherlands)

    Faddegon, Krispijn Johannes

    2009-01-01

    The thesis examines the influence of group processes on the regulatory focus of individual group members. It is demonstrated that the group situation can affect group members' regulatory focus both in a top-down fashion (via the identitiy of the group) and in a bottom-up fashion (emerging from the g

  19. Reconsidering Styles of Regulatory Enforcement

    DEFF Research Database (Denmark)

    May, Peter J.; Winter, Søren

    2000-01-01

    This study addresses enforcement styles of regulatory inspectors, based on an examination of the municipal enforcement of agro-environmental policies in Denmark. Our findings make three contributions to the regulatory literature. One contribution is to add empirical support for theorizing about i...

  20. Reconsidering Styles of Regulatory Enforcement

    DEFF Research Database (Denmark)

    J. May, Peter; Winter, Søren

    2007-01-01

    This study addresses enforcement styles of regulatory inspectors based on an examination of the municipal enforcement of agro-environmental policies in Denmark. Our findings make three contributions to the regulatory literature. One contribution is to add empirical support for theorizing about in...

  1. Regulatory Foci and Organizational Commitment

    Science.gov (United States)

    Markovits, Yannis; Ullrich, Johannes; van Dick, Rolf; Davis, Ann J.

    2008-01-01

    We use regulatory focus theory to derive specific predictions regarding the differential relationships between regulatory focus and commitment. We estimated a structural equation model using a sample of 520 private and public sector employees and found in line with our hypotheses that (a) promotion focus related more strongly to affective…

  2. Disclosure as a regulatory tool

    DEFF Research Database (Denmark)

    2006-01-01

    The chapter analyses how disclure can be used as a regulatory tool and analyses how it has been applied so far in the area of financial market law and consumer law.......The chapter analyses how disclure can be used as a regulatory tool and analyses how it has been applied so far in the area of financial market law and consumer law....

  3. Non-transcriptional regulatory processes shape transcriptional network dynamics.

    Science.gov (United States)

    Ray, J Christian J; Tabor, Jeffrey J; Igoshin, Oleg A

    2011-10-11

    Information about the extra- or intracellular environment is often captured as biochemical signals that propagate through regulatory networks. These signals eventually drive phenotypic changes, typically by altering gene expression programmes in the cell. Reconstruction of transcriptional regulatory networks has given a compelling picture of bacterial physiology, but transcriptional network maps alone often fail to describe phenotypes. Cellular response dynamics are ultimately determined by interactions between transcriptional and non-transcriptional networks, with dramatic implications for physiology and evolution. Here, we provide an overview of non-transcriptional interactions that can affect the performance of natural and synthetic bacterial regulatory networks.

  4. Data Science and Political Economy: Application to Financial Regulatory Structure

    Directory of Open Access Journals (Sweden)

    Sharyn O'Halloran

    2016-11-01

    Full Text Available The development of computational data science techniques in natural language processing and machine learning algorithms to analyze large and complex textual information opens new avenues for studying the interaction between economics and politics. We apply these techniques to analyze the design of financial regulatory structure in the United States since 1950. The analysis focuses on the delegation of discretionary authority to regulatory agencies in promulgating, implementing, and enforcing financial sector laws and overseeing compliance with them. Combining traditional studies with the new machine learning approaches enables us to go beyond the limitations of both methods and offer a more precise interpretation of the determinants of financial regulatory structure.

  5. Anti-regulatory T cells

    DEFF Research Database (Denmark)

    Andersen, Mads Hald

    2017-01-01

    Our initial understanding of immune-regulatory cells was based on the discovery of suppressor cells that assure peripheral T-cell tolerance and promote immune homeostasis. Research has particularly focused on the importance of regulatory T cells (Tregs) for immune modulation, e.g. directing host...... responses to tumours or inhibiting autoimmunity development. However, recent studies report the discovery of self-reactive pro-inflammatory T cells—termed anti-regulatory T cells (anti-Tregs)—that target immune-suppressive cells. Thus, regulatory cells can now be defined as both cells that suppress immune...... reactions as well as effector cells that counteract the effects of suppressor cells and support immune reactions. Self-reactive anti-Tregs have been described that specifically recognize human leukocyte antigen-restricted epitopes derived from proteins that are normally expressed by regulatory immune cells...

  6. Regulatory Streamlining and Improvement

    Energy Technology Data Exchange (ETDEWEB)

    Mark A. Carl

    2006-07-11

    The Interstate Oil and Gas Compact Commission (IOGCC) engaged in numerous projects outlined under the scope of work discussed in the United States Department of Energy (DOE) grant number DE-FC26-04NT15456 awarded to the IOGCC. Numerous projects were completed that were extremely valuable to state oil and gas agencies as a result of work performed utilizing resources provided by the grant. There are numerous areas in which state agencies still need assistance. This additional assistance will need to be addressed under future scopes of work submitted annually to DOE's Project Officer for this grant. This report discusses the progress of the projects outlined under the grant scope of work for the 2005-2006 areas of interest, which are as follows: Area of Interest No. 1--Regulatory Streamlining and Improvement: This area of interest continues to support IOGCC's regulatory streamlining efforts that include the identification and elimination of unnecessary duplications of efforts between and among state and federal programs dealing with exploration and production on public lands. Area of Interest No. 2--Technology: This area of interest seeks to improve efficiency in states through the identification of technologies that can reduce costs. Area of Interest No. 3--Training and Education: This area of interest is vital to upgrading the skills of regulators and industry alike. Within the National Energy Policy, there are many appropriate training and education opportunities. Education was strongly endorsed by the President's National Energy Policy Development group. Acting through the governors offices, states are very effective conduits for the dissemination of energy education information. While the IOGCC favors the development of a comprehensive, long-term energy education plan, states are also supportive of immediate action on important concerns, such as energy prices, availability and conservation. Area of Interest No. 4--Resource Assessment and

  7. 75 FR 30453 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving...

    Science.gov (United States)

    2010-06-01

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving..., Financial Industry Regulatory Authority, Inc. (``FINRA'') (f/k/a National Association of Securities Dealers... National Association of Securities Dealers, Inc., the Financial Industry Regulatory Authority, Inc., or...

  8. 75 FR 40000 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving...

    Science.gov (United States)

    2010-07-13

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving Proposed Rule Change Relating to the Restated Certificate of Incorporation of Financial Industry Regulatory Authority, Inc. July 2, 2010. On May 21, 2010, Financial Industry Regulatory Authority, Inc....

  9. UVISS preliminary visibility analysis

    DEFF Research Database (Denmark)

    Betto, Maurizio

    1998-01-01

    The goal of this work is to obtain a preliminary assessment of the sky visibility for anastronomical telescope located on the express pallet of the International SpaceStation (ISS)} taking into account the major constraints imposed on the instrument by the ISSattitude and structure. Part of the w......The goal of this work is to obtain a preliminary assessment of the sky visibility for anastronomical telescope located on the express pallet of the International SpaceStation (ISS)} taking into account the major constraints imposed on the instrument by the ISSattitude and structure. Part...

  10. Regulating regulatory T cells.

    Science.gov (United States)

    Le, N T; Chao, N

    2007-01-01

    Regulatory T cells (Tregs) are a specialized subpopulation of T cells that act to suppress activation of other immune cells and thereby maintain immune system homeostasis, self-tolerance as well as control excessive response to foreign antigens. The mere concept of Tregs was the subject of significant controversy among immunologists for many years owing to the paucity of reliable markers for defining these cells and the ambiguity of the nature and molecular basis of suppressive phenomena. However, recent advances in the molecular characterization of this cell population have firmly established their existence and their vital role in the vertebrate immune system. Of interest, accumulating evidence from both humans and experimental animal models has implicated the involvement of Tregs in the development of graft-versus-host disease (GVHD). The demonstration that Tregs could separate GVHD from graft-versus-tumor (GVT) activity suggests that their immunosuppressive potential could be manipulated to reduce GVHD without detrimental consequence on GVT effect. Although a variety of T lymphocytes with suppressive capabilities have been reported, the two best-characterized subsets are the naturally arising, intrathymic-generated Tregs (natural Tregs) and the peripherally generated, inducible Tregs (inducible Tregs). This review summarizes our current knowledge of the generation, function and regulation of these two populations of Tregs during an immune response. Their role in the development of GVHD and their therapeutic potential for the prevention and treatment of GVHD will also be described.

  11. Internationalization of regulatory requirements.

    Science.gov (United States)

    Juillet, Y

    2003-02-01

    The aim of harmonisation of medicines regulatory requirements is to allow the patient quicker access to new drugs and to avoid animal and human duplications. Harmonisation in the European Union (EU) is now completed, and has led to the submission of one dossier in one language study leading to European marketing authorizations, thanks in particular to efficacy guidelines published at the European level. With the benefit of the European experience since 1989, more than 40 guidelines have been harmonised amongst the EU, Japan and the USA through the International Conference on Harmonisation (ICH). ICH is a unique process gathering regulators and industry experts from the three regions. Its activity is built on expertise and trust. The Common Technical Document (CTD), an agreed common format for application in the three regions, is a logical follow-up to the ICH first phase harmonising the content of the dossier. The CTD final implementation in July 2003 will have considerable influence on the review process and on the exchange of information in the three regions.

  12. Regulatory norm”: myth or reality?

    Directory of Open Access Journals (Sweden)

    Hugo Alberto Marín Hernández

    2010-06-01

    Full Text Available A controversy has arisen from identifying the nature and position, in the system of sources, of the decisions taken by the regulation commissions of home public service utilities (Spanish acronym crspd. In order to explain our position towards this matter, this document makes reference to (1 the explanatory criteria of the relations between the law and the regulations in the Colombian legal code and (2 the identification of the types of regulations determined by the existence of said criteria; (3 the proposal of distinction between regulation power –regulation- and regulatory faculty –“regulatory norm”- in the national jurisprudence and doctrine, in order to finally (4 outline which are the legal nature of the regulation function and the position, in the administrative law system of sources, of the regulating products derived from the CRSPD.

  13. A biogeographic study of intermountain leeches : Preliminary report

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Preliminary report for a five year study on leeches in the intermountain west. This work began out of curiosity to determine what, besides fishes, occurred in the...

  14. Development of the Level 1 PSA Model for PGSFR Regulatory

    Energy Technology Data Exchange (ETDEWEB)

    Na, Hyun Ju; Lee, Yong Suk [FNC Tech., Yongin (Korea, Republic of); Shin, Andong; Suh, Nam Duk [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2014-10-15

    SFR (sodium-cooled fast reactor) is Gen-IV nuclear energy system, which is designed for stability, sustainability and proliferation resistance. KALIMER-600 and PGSFR (Prototype Gen-IV SFR) are under development in Korea with enhanced passive safety concepts, e.g. passive reactor shutdown, passive residual heat removal, and etc. Risk analysis from a regulatory perspective is necessary for regulatory body to support the safety and licensing review of SFR. Safety issues should be identified in the early design phase in order to prevent the unexpected cost increase and the delay of PGSFR licensing schedule. In this respect, the preliminary PSA Model of KALIMER-600 had been developed for regulatory. In this study, the development of PSA Level 1 Model is presented. The important impact factors in the risk analysis for the PGSFR, such as Core Damage Frequency (CDF), have been identified and the related safety insights have been derived. The PSA level 1 model for PGSFR regulatory is developed and the risk analysis is conducted. Regarding CDF, LOISF frequency, uncertainty parameter for passive system CCF, loss of 125V DC control center bus and damper CCF are identified as the important factors. Sensitivity analyses show that the CDF would be differentiated (lowered) according to their values.

  15. Draft Function Allocation Framework and Preliminary Technical Basis for Advanced SMR Concepts of Operations

    Energy Technology Data Exchange (ETDEWEB)

    Jacques Hugo; John Forester; David Gertman; Jeffrey Joe; Heather Medema; Julius Persensky; April Whaley

    2013-04-01

    This report presents preliminary research results from the investigation in to the development of new models and guidance for concepts of operations (ConOps) in advanced small modular reactor (aSMR) designs. In support of this objective, three important research areas were included: operating principles of multi-modular plants, functional allocation models and strategies that would affect the development of new, non-traditional concept of operations, and the requiremetns for human performance, based upon work domain analysis and current regulatory requirements. As part of the approach for this report, we outline potential functions, including the theoretical and operational foundations for the development of a new functional allocation model and the identification of specific regulatory requirements that will influence the development of future concept of operations. The report also highlights changes in research strategy prompted by confirmationof the importance of applying the work domain analysis methodology to a reference aSMR design. It is described how this methodology will enrich the findings from this phase of the project in the subsequent phases and help in identification of metrics and focused studies for the determination of human performance criteria that can be used to support the design process.

  16. Healthcare regulatory concepts in Brazil.

    Science.gov (United States)

    Oliveira, Robson Rocha de; Elias, Paulo Eduardo Mangeon

    2012-06-01

    The healthcare regulatory concepts used in Brazilian scientific publications on healthcare management were reviewed. A typo-logical classification for regulatory concepts was developed from the most current ideas in five disciplines: life sciences, law, economics, sociology and political science. Four ideas stood out: control, balance, adaptation and direction, with greatest emphasis on the technical nature of regulation. The political nature of regulation was secondary. It was considered that dis-cussion of healthcare regulatory concepts was connected with comprehension of the role that the state plays in this sector. De-finition of the forms of state intervention is the key convergence point between the different ways of conceptualizing healthcare regulation.

  17. UVISS preliminary visibility analysis

    DEFF Research Database (Denmark)

    Betto, Maurizio

    1998-01-01

    The goal of this work is to obtain a preliminary assessment of the sky visibility for anastronomical telescope located on the express pallet of the International SpaceStation (ISS)} taking into account the major constraints imposed on the instrument by the ISSattitude and structure. Part...

  18. Impact of regulatory science on global public health.

    Science.gov (United States)

    Patel, Meghal; Miller, Margaret Ann

    2012-07-01

    Regulatory science plays a vital role in protecting and promoting global public health by providing the scientific basis for ensuring that food and medical products are safe, properly labeled, and effective. Regulatory science research was first developed for the determination of product safety in the early part of the 20th Century, and continues to support innovation of the processes needed for regulatory policy decisions. Historically, public health laws and regulations were enacted following public health tragedies, and often the research tools and techniques required to execute these laws lagged behind the public health needs. Throughout history, similar public health problems relating to food and pharmaceutical products have occurred in countries around the world, and have usually led to the development of equivalent solutions. For example, most countries require a demonstration of pharmaceutical safety and efficacy prior to marketing these products using approaches that are similar to those initiated in the United States. The globalization of food and medical products has created a shift in regulatory compliance such that gaps in food and medical product safety can generate international problems. Improvements in regulatory research can advance the regulatory paradigm toward a more preventative, proactive framework. These improvements will advance at a greater pace with international collaboration by providing additional resources and new perspectives for approaching and anticipating public health problems. The following is a review of how past public health disasters have shaped the current regulatory landscape, and where innovation can facilitate the shift from reactive policies to proactive policies.

  19. Delay-independent stability of genetic regulatory networks.

    Science.gov (United States)

    Wu, Fang-Xiang

    2011-11-01

    Genetic regulatory networks can be described by nonlinear differential equations with time delays. In this paper, we study both locally and globally delay-independent stability of genetic regulatory networks, taking messenger ribonucleic acid alternative splicing into consideration. Based on nonnegative matrix theory, we first develop necessary and sufficient conditions for locally delay-independent stability of genetic regulatory networks with multiple time delays. Compared to the previous results, these conditions are easy to verify. Then we develop sufficient conditions for global delay-independent stability for genetic regulatory networks. Compared to the previous results, this sufficient condition is less conservative. To illustrate theorems developed in this paper, we analyze delay-independent stability of two genetic regulatory networks: a real-life repressilatory network with three genes and three proteins, and a synthetic gene regulatory network with five genes and seven proteins. The simulation results show that the theorems developed in this paper can effectively determine the delay-independent stability of genetic regulatory networks.

  20. Preliminary tests to determine the fatigue curve of the Ibis ACSR (Aluminum Cable Steel Reinforced) conductor; Ensaios preliminares para determinacao da curva de fadiga do cabo condutor ACSR Ibis

    Energy Technology Data Exchange (ETDEWEB)

    Rosa, Daniel M. [Universidade de Brasilia (UnB-Gama), DF (Brazil)], E-mail: danielrosa@unb.br; Fadel, Aida A.; Araujo, Jose Alexander; Ferreira, Jorge Luiz A.; Henriques, Antonio Manoel D. [Universidade de Brasilia (EnM/UnB), DF (Brazil). Dept. de Engenharia Mecanica], Emails: aida@unb.br, alex07@unb.br, jorge@unb.br, Henriques@unb.br; Hortencio, Tania M.O.S. [Companhia Energetica de Goias Distribuicao S.A. (CELG D), Goiania, GO (Brazil)], E-mail: tania.hortencio@celg.com.br

    2009-07-01

    The aim of this work was to present a fretting fatigue experimental rig for overhead conductors and to carry out a set of experiments to obtain life estimative for a standard Ibis ACSR, Aluminium Conductor Steel Reinforced. A preliminary S-N (Wohler) Curve was obtained in the medium high cycle fatigue regime. Experiments considered the occurrence of at least two wire breaks to obtain each point of the S-N curve, which was compared to CIGRE's Safe Border Line (CSBL). The experimental results showed five to ten times large lives than the ones provided by CSBL adoption. (author)

  1. The Danish Regulatory Reform of Telecommunications

    DEFF Research Database (Denmark)

    Skouby, Knud Erik

    1998-01-01

    An overview of the liberalisation process and regulatory reform of telecommunications in Denmark......An overview of the liberalisation process and regulatory reform of telecommunications in Denmark...

  2. Topaz II preliminary safety assessment

    Science.gov (United States)

    Marshall, Albert C.; Standley, Vaughn; Voss, Susan S.; Haskin, Eric

    1993-01-01

    The Strategic Defense Initiative Organization (SDIO) decided to investigate the possibility of launching a Russian Topaz II space nuclear power system. A preliminary safety assessment was conducted to determine whether or not a space mission could be conducted safely and within budget constraints. As part of this assessment, a safety policy and safety functional requirements were developed to guide both the safety assessment and future Topaz II activities. A review of the Russian flight safety program was conducted and documented. Our preliminary safety assessment included a top level event tree, neutronic analysis of normal and accident configurations, an evaluation of temperature coefficients of reactivity, a reentry and disposal analysis, and analysis of postulated launch abort impact accidents, and an analysis of postulated propellant fire and explosion accidents. Based on the assessment, it appears that it will be possible to safely launch the Topaz II system in the U.S. with some possible system modifications. The principal system modifications will probably include design changes to preclude water flooded criticality and to assure intact reentry.

  3. Regulatory Snapshots: integrative mining of regulatory modules from expression time series and regulatory networks.

    Directory of Open Access Journals (Sweden)

    Joana P Gonçalves

    Full Text Available Explaining regulatory mechanisms is crucial to understand complex cellular responses leading to system perturbations. Some strategies reverse engineer regulatory interactions from experimental data, while others identify functional regulatory units (modules under the assumption that biological systems yield a modular organization. Most modular studies focus on network structure and static properties, ignoring that gene regulation is largely driven by stimulus-response behavior. Expression time series are key to gain insight into dynamics, but have been insufficiently explored by current methods, which often (1 apply generic algorithms unsuited for expression analysis over time, due to inability to maintain the chronology of events or incorporate time dependency; (2 ignore local patterns, abundant in most interesting cases of transcriptional activity; (3 neglect physical binding or lack automatic association of regulators, focusing mainly on expression patterns; or (4 limit the discovery to a predefined number of modules. We propose Regulatory Snapshots, an integrative mining approach to identify regulatory modules over time by combining transcriptional control with response, while overcoming the above challenges. Temporal biclustering is first used to reveal transcriptional modules composed of genes showing coherent expression profiles over time. Personalized ranking is then applied to prioritize prominent regulators targeting the modules at each time point using a network of documented regulatory associations and the expression data. Custom graphics are finally depicted to expose the regulatory activity in a module at consecutive time points (snapshots. Regulatory Snapshots successfully unraveled modules underlying yeast response to heat shock and human epithelial-to-mesenchymal transition, based on regulations documented in the YEASTRACT and JASPAR databases, respectively, and available expression data. Regulatory players involved in

  4. Taking Stock of Regulatory Variation.

    Science.gov (United States)

    Maurano, Matthew T; Stamatoyannopoulos, John A

    2015-07-29

    Three recent studies measure individual variation in regulatory DNA accessibility. What do they tell us about the prospects of assessing variation in single cells and across populations? Copyright © 2015 Elsevier Inc. All rights reserved.

  5. Current Regulations and Regulatory Actions

    Science.gov (United States)

    This site will provide basic information on clean air permitting under the title V operating permits program, provide access to state and regional permitting programs, and maintain access to proposed and final regulatory requirements.

  6. Regulatory facility guide for Ohio

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, S.S.; Bock, R.E.; Francis, M.W.; Gove, R.M.; Johnson, P.E.; Kovac, F.M.; Mynatt, J.O. [Oak Ridge National Lab., TN (United States); Rymer, A.C. [Transportation Consulting Services, Knoxville, TN (United States)

    1994-02-28

    The Regulatory Facility Guide (RFG) has been developed for the DOE and contractor facilities located in the state of Ohio. It provides detailed compilations of international, federal, and state transportation-related regulations applicable to shipments originating at destined to Ohio facilities. This RFG was developed as an additional resource tool for use both by traffic managers who must ensure that transportation operations are in full compliance with all applicable regulatory requirements and by oversight personnel who must verify compliance activities.

  7. Electronic Commerce Removing Regulatory Impediments

    Science.gov (United States)

    1992-05-01

    AD-A252 691 ELECTRONIC COMMERCE Removing Regulatory Impediments ~DuiG A% ELECTE I JUL1 8 1992 0 C D Daniel J. Drake John A. Ciucci ... - ""N ST AT KE...Management Institute 6400 Goldsboro Road Bethesda, Maryland 20817-5886 92 LMI Executive Summary ELECTRONIC COMMERCE : REMOVING REGULATORY IMPEDIMENTS... Electronic Commerce techniques, such as electronic mail and electronic data interchange (EDI), enable Government agencies to conduct business without the

  8. The Michigan regulatory incentives study for electric utilities. Phase 1, Final report

    Energy Technology Data Exchange (ETDEWEB)

    Reid, M.W.; Weaver, E.M. [Barakat and Chamberlin, Inc., Oakland, CA (United States)

    1991-06-17

    This is the final report of Phase I of the Michigan Regulatory Incentives Study for Electric Utilities, a three-phase review of Michigan`s regulatory system and its effects on resource selection by electric utilities. The goal of Phase I is to identify and analyze financial incentive mechanisms that encourage selection of resources in accord with the principles of integrated resource planning (IRP) or least-cost planning (LCP). Subsequent study phases will involve further analysis of options and possibly a collaborative formal effort to propose regulatory changes. The Phase I analysis proceeded in three steps: (1) identification and review of existing regulatory practices that affect utilities; selection of resources, particularly DSM; (2) preliminary analysis of ten financial mechanisms, and selection of three for further study; (3) detailed analysis of the three mechanisms, including consideration of how they could be implemented in Michigan and financial modeling of their likely impacts on utilities and ratepayers.

  9. 77 FR 13547 - Certain Frozen Warmwater Shrimp From the Socialist Republic of Vietnam: Preliminary Results of...

    Science.gov (United States)

    2012-03-07

    ... (Penaeus vannemei), banana prawn (Penaeus merguiensis), fleshy prawn (Penaeus chinensis), giant river prawn... Film, Sheet, and Strip from the People's Republic of China: Preliminary Determination of Sales at...

  10. Experience in implementing regulatory requirements to protect against industrial sabotage

    Energy Technology Data Exchange (ETDEWEB)

    Knuth, D.F.

    1978-01-01

    Some of the problems and concerns in implementing the current regulatory requirements in physical protection of nuclear power plants are discussed. Until 1973, the Nuclear Regulatory Commission (NRC) was of the opinion that a determined group of professional saboteurs was beyond the scope of protection required. Since then regulatory changes have altered that concept; each successive regulatory change envisions a higher level of threat, and, hence, requires more provisions to protect the facilities. The author contends that, in some areas, NRC's decisions were hastily conceived with unrealistic implementation schedules. These decisions and regulations, if fully implemented, could be counterproductive to maintaining good security in a nuclear power plant, and are counterproductive to safety and operability of the plants.

  11. Small regulatory RNA and Legionella pneumophila

    Directory of Open Access Journals (Sweden)

    Sebastien P Faucher

    2011-05-01

    Full Text Available Legionella pneumophila is a gram-negative bacterial species that is ubiquitous in almost any aqueous environment. It is the agent of Legionnaires’ disease, an acute and often under-reported form of pneumonia. In mammals, L. pneumophila replicates inside macrophages within a modified vacuole. Many protein regulators have been identified that control virulence-related properties, including RpoS, LetA/LetS and PmrA/PmrB. In the past few years, the importance of regulation of virulence factors by small regulatory RNA has been increasingly appreciated. This is also the case in L. pneumophila where three sRNAs (RsmY, RsmZ and 6S RNA were recently shown to be important determinants of virulence regulation and 79 actively transcribed sRNAs were identified. In this review we describe current knowledge about sRNAs and their regulatory properties and how this relates to the known regulatory systems of L. pneumophila. We also provide a model for sRNA-mediated control of gene expression that serves as a framework for understanding the regulation of virulence-related properties of L. pneumophila.

  12. 75 FR 42730 - Goodwin Power, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Science.gov (United States)

    2010-07-22

    ... Energy Regulatory Commission Goodwin Power, LLC; Notice of Preliminary Permit Application Accepted for..., 2010, Goodwin Power, LLC filed an application, pursuant to section 4(f) of the Federal Power Act, proposing to study the feasibility of the Goodwin Dam Project, located on the Stanislaus River in...

  13. 76 FR 20974 - Owyhee Hydro, LLC; of Preliminary Permit Application Accepted for Filing and Soliciting Comments...

    Science.gov (United States)

    2011-04-14

    ... Energy Regulatory Commission Owyhee Hydro, LLC; of Preliminary Permit Application Accepted for Filing and Soliciting Comments, Motions To Intervene, and Competing Applications On January 18, 2011, Owyhee Hydro, LLC...), proposing to study the feasibility of the Owyhee Pumped Storage Project (project) to be located on...

  14. 77 FR 76026 - Tlingit-Haida Regional Electric Authority; Notice of Preliminary Permit Application Accepted for...

    Science.gov (United States)

    2012-12-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Tlingit-Haida Regional Electric Authority; Notice of Preliminary Permit Application Accepted for Filing and Soliciting Comments and Motions To Intervene On June 12, 2012,...

  15. 77 FR 38795 - Dolores Water Conservancy District; Notice of Competing Preliminary Permit Application Accepted...

    Science.gov (United States)

    2012-06-29

    ... Energy Regulatory Commission Dolores Water Conservancy District; Notice of Competing Preliminary Permit Application Accepted for Filing and Soliciting Comments and Motions To Intervene On May 10, 2012, Dolores... located on Plateau Creek, near the town of Dolores, Montezuma County, Colorado. The project...

  16. 77 FR 35377 - Dolores Water Conservancy District; Notice of Completing Preliminary Permit Application Accepted...

    Science.gov (United States)

    2012-06-13

    ... Energy Regulatory Commission Dolores Water Conservancy District; Notice of Completing Preliminary Permit Application Accepted for Filing and Soliciting Comments and Motions To Intervene On May 10, 2012, Dolores... located on Plateau Creek, near the town of Dolores, Montezuma County, Colorado. The project...

  17. 77 FR 15749 - Twin Lakes Canal Company; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2012-03-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Twin Lakes Canal Company; Notice of Preliminary Permit Application Accepted for Filing and Soliciting Comments, Motions To Intervene, and Competing Applications On March 8, 2012, Twin Lakes Canal Company filed...

  18. 76 FR 25320 - Hawthorn Water LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Science.gov (United States)

    2011-05-04

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Hawthorn Water LLC; Notice of Preliminary Permit Application Accepted for..., Hawthorn Water LLC filed an application, pursuant to section 4(f) of the Federal Power Act, proposing...

  19. Preliminary perspectives gaines from individual plant examination of external events (IPEEE) seismic and fire submittal review

    Energy Technology Data Exchange (ETDEWEB)

    Chen, J.T.; Connell, E.; Chokshi, N. [NRC, Washington, DC (United States)] [and others

    1997-02-01

    As a result of the U.S. Nuclear Regulatory Commission (USNRC) initiated Individual plant Examination of External Events (IPEEE) program, every operating nuclear power reactor in the United States has performed an assessment of severe accident due to external events. This paper provides a summary of the preliminary insights gained through the review of 24 IPEEE submittals.

  20. 76 FR 75542 - Porcupine Dam Hydropower Project; Notice of Preliminary Permit Application Accepted for Filing...

    Science.gov (United States)

    2011-12-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Porcupine Dam Hydropower Project; Notice of Preliminary Permit Application... Dam Hydropower Project to be located on the East Fork of the Little Bear River near the town of...

  1. 76 FR 4893 - FFP Missouri 13, LLC, Grays Hydro, LLC; Notice Announcing Preliminary Permit Drawing

    Science.gov (United States)

    2011-01-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission FFP Missouri 13, LLC, Grays Hydro, LLC; Notice Announcing Preliminary Permit... River in Greene County, Pennsylvania.\\1\\ The applications were filed by FFP Missouri 13, LLC,...

  2. 77 FR 4290 - Conway Ranch Hydropower Project; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2012-01-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Conway Ranch Hydropower Project; Notice of Preliminary Permit Application... the Federal Power Act (FPA), proposing to study the feasibility of the Conway Ranch Hydropower Project...

  3. 77 FR 63301 - Juneau Hydropower, Inc.; Notice of Draft License Application and Preliminary Draft Environmental...

    Science.gov (United States)

    2012-10-16

    ... Energy Regulatory Commission Juneau Hydropower, Inc.; Notice of Draft License Application and Preliminary...: August 31, 2012. d. Applicant: Juneau Hydropower, Inc. e. Name of Project: Sweetheart Lake Hydroelectric... Hydropower, Inc., P.O. Box 22775, Juneau, AK 99802; 907-789-2775, email: duff.mitchell@juneauhydro.com . i...

  4. 75 FR 59707 - Coastal Hydropower, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2010-09-28

    ... Energy Regulatory Commission Coastal Hydropower, LLC; Notice of Preliminary Permit Application Accepted..., 2010. On February 9, 2010, and supplemented on July 16, 2010, Coastal Hydropower, LLC filed an...-hours. Applicant Contact: Neil Anderson, Coastal Hydropower, LLC, Key Centre, 601 108th Avenue, NE...

  5. 75 FR 59706 - Coastal Hydropower, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2010-09-28

    ... Federal Energy Regulatory Commission Coastal Hydropower, LLC; Notice of Preliminary Permit Application..., 2010. On February 9, 2010, and supplemented on July 16, 2010, Coastal Hydropower, LLC filed an..., Coastal Hydropower, LLC, Key Centre, 601 108th Avenue, NE., Suite 1900, Bellevue, WA 98004; phone: (425...

  6. 75 FR 35778 - Modesto Irrigation District and Turlock Irrigation District; Notice of Preliminary Permit...

    Science.gov (United States)

    2010-06-23

    ... Energy Regulatory Commission Modesto Irrigation District and Turlock Irrigation District; Notice of... Competing Applications June 16, 2010. On February 1, 2010, Modesto Irrigation District and Turlock Irrigation District filed an application for a preliminary permit, pursuant to section 4(f) of the...

  7. 76 FR 9770 - Utah Board of Water Resources Notice of Successive Preliminary Permit Application Accepted for...

    Science.gov (United States)

    2011-02-22

    ... Energy Regulatory Commission Utah Board of Water Resources Notice of Successive Preliminary Permit Application Accepted for Filing and Soliciting Comments, Motions To Intervene, and Competing Applications On February 1, 2011, the Utah Board of Water Resources filed an application for a successive...

  8. 75 FR 12533 - The Power Company, Inc.; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2010-03-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission The Power Company, Inc.; Notice of Preliminary Permit Application Accepted... December 21, 2009, The Power Company, Inc. filed an application, pursuant to Section 4(f) of the...

  9. 75 FR 11153 - Main Mill Street Investments, LLC; Notice of Preliminary Permit Application Accepted for Filing...

    Science.gov (United States)

    2010-03-10

    ... Energy Regulatory Commission Main Mill Street Investments, LLC; Notice of Preliminary Permit Application.... On November 16, Main Mill Street Investments, LLC (Main Mill Street Investments) filed an application... feasibility of the Imperial Mill Dam Hydroelectric Project No. 13631, to be located at the existing...

  10. 75 FR 18190 - New Jersey Water Supply Authority; Notice of Preliminary Permit Application Accepted for Filing...

    Science.gov (United States)

    2010-04-09

    ... Energy Regulatory Commission New Jersey Water Supply Authority; Notice of Preliminary Permit Application.... On March 17, 2009, the New Jersey Water Supply Authority (New Jersey WSA) filed an application... generation of about 628 megawatt-hours. Applicant Contact: Edward Buss, P.E., New Jersey Water...

  11. 75 FR 66082 - Bishop Tungsten Development, LLC; Notice of Preliminary Permit Application Accepted for Filing...

    Science.gov (United States)

    2010-10-27

    ... Federal Energy Regulatory Commission Bishop Tungsten Development, LLC; Notice of Preliminary Permit... October 20, 2010. On November 9, 2009, Bishop Tungsten Development, LLC filed an application for a... Tungsten Development, LLC, 725 9050 Pine Creek Road, Bishop, CA 93514; phone: (706) 387-2080. FERC...

  12. Evolution of evolvability in gene regulatory networks.

    Directory of Open Access Journals (Sweden)

    Anton Crombach

    Full Text Available Gene regulatory networks are perhaps the most important organizational level in the cell where signals from the cell state and the outside environment are integrated in terms of activation and inhibition of genes. For the last decade, the study of such networks has been fueled by large-scale experiments and renewed attention from the theoretical field. Different models have been proposed to, for instance, investigate expression dynamics, explain the network topology we observe in bacteria and yeast, and for the analysis of evolvability and robustness of such networks. Yet how these gene regulatory networks evolve and become evolvable remains an open question. An individual-oriented evolutionary model is used to shed light on this matter. Each individual has a genome from which its gene regulatory network is derived. Mutations, such as gene duplications and deletions, alter the genome, while the resulting network determines the gene expression pattern and hence fitness. With this protocol we let a population of individuals evolve under Darwinian selection in an environment that changes through time. Our work demonstrates that long-term evolution of complex gene regulatory networks in a changing environment can lead to a striking increase in the efficiency of generating beneficial mutations. We show that the population evolves towards genotype-phenotype mappings that allow for an orchestrated network-wide change in the gene expression pattern, requiring only a few specific gene indels. The genes involved are hubs of the networks, or directly influencing the hubs. Moreover, throughout the evolutionary trajectory the networks maintain their mutational robustness. In other words, evolution in an alternating environment leads to a network that is sensitive to a small class of beneficial mutations, while the majority of mutations remain neutral: an example of evolution of evolvability.

  13. On Preliminary Breakdown

    Science.gov (United States)

    Beasley, W. H.; Petersen, D.

    2013-12-01

    The preliminary breakdown phase of a negative cloud-to-ground lightning flash was observed in detail. Observations were made with a Photron SA1.1 high-speed video camera operating at 9,000 frames per second, fast optical sensors, a flat-plate electric field antenna covering the SLF to MF band, and VHF and UHF radio receivers with bandwidths of 20 MHz. Bright stepwise extensions of a negative leader were observed at an altitude of 8 km during the first few milliseconds of the flash, and were coincident with bipolar electric field pulses called 'characteristic pulses'. The 2-D step lengths of the preliminary processes were in excess of 100 meters, with some 2-D step lengths in excess of 200 meters. Smaller and shorter unipolar electric field pulses were superposed onto the bipolar electric field pulses, and were coincident with VHF and UHF radio pulses. After a few milliseconds, the emerging negative stepped leader system showed a marked decrease in luminosity, step length, and propagation velocity. Details of these events will be discussed, including the possibility that the preliminary breakdown phase consists not of a single developing lightning leader system, but of multiple smaller lightning leader systems that eventually join together into a single system.

  14. Regulatory Expectations for Safety Culture

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Su Jin; Oh, Jang Jin; Choi, Young Sung [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2014-05-15

    The oversight of licensee's safety culture becomes an important issue that attracts great public and political concerns recently in Korea. Beginning from the intended violation of rules, a series of corruptions, documents forgery and disclosure of wrong-doings made the public think that the whole mindset of nuclear workers has been inadequate. Thus, they are demanding that safety culture shall be improved and that regulatory body shall play more roles and responsibilities for the improvements and oversight for them. This paper introduces, as an effort of regulatory side, recent changes in the role of regulators in safety culture, regulatory expectations on the desired status of licensee's safety culture, the pilot inspection program for safety culture and research activity for the development of oversight system. After the Fukushima accident in Japan 2011, many critics has searched for cultural factors that caused the unacceptable negligence pervaded in Japan nuclear society and the renewed emphasis has been placed on rebuilding safety culture by operators, regulators, and relevant institutions globally. Significant progress has been made in how to approach safety culture and led to a new perspective different from the existing normative assessment method both in operators and regulatory side. Regulatory expectations and oversight of them are based on such a new holistic concept for human, organizational and cultural elements to maintain and strengthen the integrity of defense in depth and consequently nuclear safety.

  15. Using Inequality Measures to Incorporate Environmental Justice into Regulatory Analyses

    Directory of Open Access Journals (Sweden)

    Jonathan I. Levy

    2013-08-01

    Full Text Available Formally evaluating how specific policy measures influence environmental justice is challenging, especially in the context of regulatory analyses in which quantitative comparisons are the norm. However, there is a large literature on developing and applying quantitative measures of health inequality in other settings, and these measures may be applicable to environmental regulatory analyses. In this paper, we provide information to assist policy decision makers in determining the viability of using measures of health inequality in the context of environmental regulatory analyses. We conclude that quantification of the distribution of inequalities in health outcomes across social groups of concern, considering both within-group and between-group comparisons, would be consistent with both the structure of regulatory analysis and the core definition of environmental justice. Appropriate application of inequality indicators requires thorough characterization of the baseline distribution of exposures and risks, leveraging data generally available within regulatory analyses. Multiple inequality indicators may be applicable to regulatory analyses, and the choice among indicators should be based on explicit value judgments regarding the dimensions of environmental justice of greatest interest.

  16. Regulatory mode preferences for autonomy supporting versus controlling instructional styles.

    Science.gov (United States)

    Pierro, Antonio; Presaghi, Fabio; Higgins, Tory E; Kruglanski, Arie W

    2009-12-01

    Three studies carried out in educational settings examined determinants of teacher's instructional styles and students' degree of satisfaction with the learning climates created by such styles. Based upon regulatory mode theory, Studies 1 and 2 tested the hypotheses that teachers' locomotion orientation will be positively related, and their assessment orientation will be negatively related, to autonomy supportive (vs. controlling) instructional styles. Study 3 tested the hypothesis that students' regulatory mode will exhibit a fit effect with the prevalent learning climate in their school. Participants for Study 1 were 378 teachers (278 females); for Study 2 were 96 teachers (65 females); and for Study 3 were 190 students (all males). Participants completed questionnaires that included measures of teaching styles (Studies 1 and 2), perceived learning climate and satisfaction (Study 3), and regulatory mode orientations (Studies 1 and 3). In Study 2 regulatory mode orientations were experimentally induced. Results confirmed that teachers' autonomy supportive versus controlling styles were positively related to their locomotion orientations and negatively related to their assessment orientation, and that students with a stronger locomotion (vs. assessment) orientation reported a higher level of satisfaction when the learning climate was perceived as autonomy supportive (vs. controlling). The present studies show that teachers' preference for adopting an instructional style is influenced by their regulatory mode orientations, and that the effects of a learning climate on students' satisfaction are contingent on a fit between type of learning climate and students' regulatory mode orientations.

  17. Determination of Aluminum Residue in Baking and Flour Foods and Regulatory Proposals%焙烤和面制食品中铝残留量的测定及监管建议

    Institute of Scientific and Technical Information of China (English)

    奕水明; 钱文捷

    2016-01-01

    Objective To perform a sampling survey on the amount of aluminum residue in baking and flour foods in Jiaxing city. Methods According to GB/T 5009. 182-2003 Method Standard for Determination of Aluminum in Pasta, the samples were prepared by microwave digestion or dry or wet digestion. The amount of aluminum residue in the final products was measured by spectrophotometer. Results The content and qualified rate of aluminum residue was determined accrding to the requirements of State Food and Drug Administration. The qualified rate of aluminum residue in baking and flour foods in Jiaxing city was 95.1%. Conclusion The overall situation for the use of additives containing aluminum in baking and flour foods in Jiaxing is good, but the usage of aluminum of a few products exceeds the standard.%目的:抽样调查嘉兴地区生产的焙烤和面制食品中铝残留量。方法按GB/T 5009.182-2003《面制食品中铝的测定》方法标准,样品前处理采用微波消解、干法或湿法消解,终产品中铝残留量用分光光度计测定。结果按照国家食药总局规定要求,对其铝残留量检测和判定,合格率为95.1%。结论嘉兴地区焙烤和面制食品中使用含铝添加剂的总体情况较好,少数产品使用量超标。

  18. Regulatory processes in Aspergillus niger

    DEFF Research Database (Denmark)

    Poulsen, Lars

    some disadvantages as well, those are byproduct formation, secretion of proteolytic enzymes and formation of mycotoxins. The aim of this project was to reduce these disadvantages, though investigating the regulatory processes. The first objective was to study the regulatory events leading to A. niger......T. The physiological batch characterization showed that the ΔprtT strain had the lowest protease activity (fivefold reduced), but also featured excessive CO2 yield, reduced growth rate and lower biomass yields. The ΔprtB strain had a close to twofold reduced levels of secreted proteases but with additional beneficial...

  19. Purification, crystallization and preliminary X-ray analysis of the DNA-binding domain of AdpA, the central transcription factor in the A-factor regulatory cascade in the filamentous bacterium Streptomyces griseus, in complex with a duplex DNA.

    Science.gov (United States)

    Yao, Ming Dong; Miyazono, Ken-ichi; Ohtsuka, Jun; Hirano, Setsu; Nagata, Koji; Horinouchi, Sueharu; Ohnishi, Yasuo; Tanokura, Masaru

    2012-08-01

    Streptomyces griseus AdpA is the central transcription factor in the A-factor regulatory cascade and activates a number of genes that are required for both secondary metabolism and morphological differentiation, leading to the onset of streptomycin biosynthesis as well as aerial mycelium formation and sporulation. The DNA-binding domain of AdpA consists of two helix-turn-helix DNA-binding motifs and shows low nucleotide-sequence specificity. To reveal the molecular basis of the low nucleotide-sequence specificity, an attempt was made to obtain cocrystals of the DNA-binding domain of AdpA and several kinds of duplex DNA. The best diffracting crystal was obtained using a 14-mer duplex DNA with two-nucleotide overhangs at the 5'-ends. The crystal diffracted X-rays to 2.8 Å resolution and belonged to space group C222(1), with unit-cell parameters a = 76.86, b = 100.96, c = 101.25 Å. The Matthews coefficient (V(M) = 3.71 Å(3) Da(-1)) indicated that the crystal was most likely to contain one DNA-binding domain of AdpA and one duplex DNA in the asymmetric unit, with a solvent content of 66.8%.

  20. Pesticide regulations for agriculture: Chemically flawed regulatory practice.

    Science.gov (United States)

    Gamble, Donald S; Bruccoleri, Aldo G

    2016-08-02

    Two categories of pesticide soil models now exist. Government regulatory agencies use pesticide fate and transport hydrology models, including versions of PRZM.gw. They have good descriptions of pesticide transport by water flow. Their descriptions of chemical mechanisms are unrealistic, having been postulated using the universally accepted but incorrect pesticide soil science. The objective of this work is to report experimental tests of a pesticide soil model in use by regulatory agencies and to suggest possible improvements. Tests with experimentally based data explain why PRZM.gw predictions can be wrong by orders of magnitude. Predictive spreadsheet models are the other category. They are experimentally based, with chemical stoichiometry applied to integral kinetic rate laws for sorption, desorption, intra-particle diffusion, and chemical reactions. They do not account for pesticide transport through soils. Each category of models therefore lacks what the other could provide. They need to be either harmonized or replaced. Some preliminary tests indicate that an experimental mismatch between the categories of models will have to be resolved. Reports of pesticides in the environment and the medical problems that overlap geographically indicate that government regulatory practice needs to account for chemical kinetics and mechanisms. Questions about possible cause and effect links could then be investigated.

  1. Regulatory treatment of allowances and compliance costs

    Energy Technology Data Exchange (ETDEWEB)

    Rose, K. [National Regulatory Research Institute, Columbus, OH (United States)

    1993-07-01

    The Clean Air Act Amendments of 1990 (CAAA) established a national emission allowance trading system, a market-based form of environmental regulation designed to reduce and limit sulfur dioxide emissions. However, the allowance trading system is being applied primarily to an economically regulated electric utility industry. The combining of the new form of environmental regulation and economic regulation of electric utilities has raised a number of questions including what the role should be of the federal and state utility regulating commissions and how those actions will affect the decision making process of the utilities and the allowance market. There are several dimensions to the regulatory problems that commissions face. Allowances and utility compliance expenditures have implications for least-cost/IPR (integrated resource planning), prudence review procedures, holding company and multistate utility regulation and ratemaking treatment. The focus of this paper is on the ratemaking treatment. The following topics are covered: ratemaking treatment of allowances and compliance costs; Traditional cost-recovery mechanisms; limitations to the traditional approach; traditional approach and the allowance trading market; market-based cost recovery mechanisms; methods of determining the benchmark; determining the split between ratepayers and the utility; other regulatory approaches; limitations of incentive mechanisms.

  2. Environmental Survey preliminary report

    Energy Technology Data Exchange (ETDEWEB)

    1988-04-01

    This report presents the preliminary findings from the first phase of the Environmental Survey of the United States Department of Energy (DOE) Sandia National Laboratories conducted August 17 through September 4, 1987. The objective of the Survey is to identify environmental problems and areas of environmental risk associated with Sandia National Laboratories-Albuquerque (SNLA). The Survey covers all environmental media and all areas of environmental regulation. It is being performed in accordance with the DOE Environmental Survey Manual. This phase of the Survey involves the review of existing site environmental data, observations of the operations carried on at SNLA, and interviews with site personnel. 85 refs., 49 figs., 48 tabs.

  3. Ruiz Volcano: Preliminary report

    Science.gov (United States)

    Ruiz Volcano, Colombia (4.88°N, 75.32°W). All times are local (= GMT -5 hours).An explosive eruption on November 13, 1985, melted ice and snow in the summit area, generating lahars that flowed tens of kilometers down flank river valleys, killing more than 20,000 people. This is history's fourth largest single-eruption death toll, behind only Tambora in 1815 (92,000), Krakatau in 1883 (36,000), and Mount Pelée in May 1902 (28,000). The following briefly summarizes the very preliminary and inevitably conflicting information that had been received by press time.

  4. On the Concept of Cis-regulatory Information: From Sequence Motifs to Logic Functions

    Science.gov (United States)

    Tarpine, Ryan; Istrail, Sorin

    The regulatory genome is about the “system level organization of the core genomic regulatory apparatus, and how this is the locus of causality underlying the twin phenomena of animal development and animal evolution” (E.H. Davidson. The Regulatory Genome: Gene Regulatory Networks in Development and Evolution, Academic Press, 2006). Information processing in the regulatory genome is done through regulatory states, defined as sets of transcription factors (sequence-specific DNA binding proteins which determine gene expression) that are expressed and active at the same time. The core information processing machinery consists of modular DNA sequence elements, called cis-modules, that interact with transcription factors. The cis-modules “read” the information contained in the regulatory state of the cell through transcription factor binding, “process” it, and directly or indirectly communicate with the basal transcription apparatus to determine gene expression. This endowment of each gene with the information-receiving capacity through their cis-regulatory modules is essential for the response to every possible regulatory state to which it might be exposed during all phases of the life cycle and in all cell types. We present here a set of challenges addressed by our CYRENE research project aimed at studying the cis-regulatory code of the regulatory genome. The CYRENE Project is devoted to (1) the construction of a database, the cis-Lexicon, containing comprehensive information across species about experimentally validated cis-regulatory modules; and (2) the software development of a next-generation genome browser, the cis-Browser, specialized for the regulatory genome. The presentation is anchored on three main computational challenges: the Gene Naming Problem, the Consensus Sequence Bottleneck Problem, and the Logic Function Inference Problem.

  5. GC/MS profiling of gamma-hydroxybutyrate and precursors in various animal tissues using automatic solid-phase extraction. Preliminary investigations of its potential interest in postmortem interval determination.

    Science.gov (United States)

    Richard, Damien; Ling, Bing; Authier, Nicolas; Faict, Thierry W; Eschalier, Alain; Coudoré, François

    2005-03-01

    To quantify gamma-hydroxybutyrate (GHB) and its physiological metabolites, gamma-aminobutyric acid (GABA), 1,4-butanediol (1,4-BD), and gamma-butyrolactone (GBL) in various animal tissues (kidney, muscle, heart, liver, blood, brain cortex, thalamus, hypothalamus, hippocampus, or pons), an original gas chromatographic/mass spectrometric method with a automated solid-phase extraction by Oasis MCX cartridges on a Gilson Aspec Xli was developed. Using such apparatus allowed the limit of detection (LOD) of target compounds to be significantly lowered (LOD: 0.027, 0.025, and 5.7 microg/mL for GHB, 1,4-BD, and GABA, respectively, in 200 microL or microg of sample). After validation of each analytical step, the satisfactory performances of the apparatus in conjunction with the rapidity and ease of the extraction step make it suitable for simultaneous assay of GHB, 1,4-BD, GBL, and GABA. The method was used to test the correlation between GHB levels in tissues obtained at different times after death of male Sprague-Dawley rats and the postmortem interval. Preliminary results show a linear increase of GHB levels in relation to time of death in thoracic blood and central nervous system of animals kept at 15 and 20 degrees C.

  6. 75 FR 70757 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving a...

    Science.gov (United States)

    2010-11-18

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving a... 12, 2010. I. Introduction On August 6, 2010, the Financial Industry Regulatory Authority, Inc... Kimmel, Executive Director, Financial Information Forum, to Elizabeth M. Murphy, Secretary,...

  7. 77 FR 47470 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of...

    Science.gov (United States)

    2012-08-08

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Withdrawal... FINRA Rulebook August 2, 2012. On April 22, 2009, the Financial Industry Regulatory Authority,...

  8. 77 FR 55517 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving a...

    Science.gov (United States)

    2012-09-10

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving a.... Introduction On May 24, 2012, Financial Industry Regulatory Authority, Inc. (``FINRA'') filed with the... General Counsel, Securities Industry and Financial Markets Association, dated June 26, 2012...

  9. 75 FR 62439 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving a...

    Science.gov (United States)

    2010-10-08

    ...-2010-043] Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving..., 2010. I. Introduction On August 6, 2010, the Financial Industry Regulatory Authority, Inc. (``FINRA..., 2010 (``Wiesenberg Letter''); Letter from Manisha Kimmel, Executive Director, Financial...

  10. 77 FR 12340 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Granting...

    Science.gov (United States)

    2012-02-29

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Granting... Accounting Support Fee February 23, 2012. I. Introduction On December 20, 2011, the Financial Industry Regulatory Authority, Inc. (``FINRA'') filed with the Securities and Exchange Commission...

  11. 76 FR 20757 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Granting...

    Science.gov (United States)

    2011-04-13

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Granting... February 4, 2011, the Financial Industry Regulatory Authority, Inc. (``FINRA'') filed with the...

  12. 75 FR 61793 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving...

    Science.gov (United States)

    2010-10-06

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving... Encrypted September 29, 2010. I. Introduction On June 2, 2010, the Financial Industry Regulatory Authority... Taunt, Chief Executive Officer, Regal Financial Group, to Elizabeth M. Murphy, Secretary,...

  13. Subordinate regulatory mode and leader power: Interpersonal regulatory complementarity predicts task performance

    NARCIS (Netherlands)

    Hamstra, M.R.W.; Orehek, E.; Holleman, M.

    2014-01-01

    This research examines the implications of locomotion regulatory mode (orientation toward making progress on goals) and assessment regulatory mode (orientation toward critically evaluating alternatives) for employees' performance. Regulatory mode theory suggests that, although these are both integra

  14. Fate of Nitrogen on California Dairies as Measured by Regulatory Reporting

    Science.gov (United States)

    Parsons, T.; Lee, E.; Harter, T.

    2016-12-01

    California is the largest dairy producer in the Unites States, generating over 20% of U.S. milk and cheese. Many California dairy herds live in concentrated animal feeding operations (CAFOs) in the Central Valley. Surrounding these CAFOs, dairies also manage a significant amount of forage land where animal waste is recycled. Through expansion and more efficient production, the milk and manure output of the Central Valley dairies increased nearly exponentially for five decades, until animal numbers levelled off in the 2000s. Due to this expansion, specifically in the Central Valley, the dairy industry poses significant concerns in regard to nitrate contamination and salinization of groundwater. In 2007, new regulations were placed upon the California dairy industry, pertaining to nonpoint source emissions to groundwater. We have digitized and are currently analyzing these annual dairy reports submitted by individual operators to the regulatory agency (Regional Water Boards) to assess the fate of nutrients on dairies in the Central Valley. We are able to assess data completeness and consistency, annual trends over the first eight years of the program, and evaluate the reporting program. Our analysis can be used to determine potential groundwater nitrate impacts based on field nitrogen mass balance. Preliminary results indicate that increased regulation and efforts made by dairy operations have decreased the presence of excess nutrients on dairy lands, although improvements need to be made to the reporting process in order to further this progress.

  15. Regulatory Mode Preferences for Autonomy Supporting versus Controlling Instructional Styles

    Science.gov (United States)

    Pierro, Antonio; Presaghi, Fabio; Higgins, Tory E.; Kruglanski, Arie W.

    2009-01-01

    Background: Three studies carried out in educational settings examined determinants of teacher's instructional styles and students' degree of satisfaction with the learning climates created by such styles. Aims: Based upon regulatory mode theory, Studies 1 and 2 tested the hypotheses that teachers' locomotion orientation will be positively…

  16. Current european regulatory perspectives on insulin analogues

    Directory of Open Access Journals (Sweden)

    Enzmann Harald G

    2011-07-01

    Full Text Available Abstract Insulin analogues are increasingly considered as an alternative to human insulin in the therapy of diabetes mellitus. Insulin analogues (IAs are chemically different from human insulin and may have different pharmacokinetic or pharmacodynamic properties. The significance of the modifications of the insulin molecule for the safety profile of IAs must be considered. This review describes the regulatory procedure and the expectations for the scientific content of European marketing authorization applications for innovative IAs submitted to the European Medicines Agency. Particular consideration is given to a potential cancer hazard. Specific regulatory guidance on how to address a possible carcinogenic or tumor promoting effect of innovative IAs in non-clinical studies is available. After marketing authorization, the factual access of patients to the new product will be determined to great extent by health technology assessment bodies, reimbursement decisions and the price. Whereas the marketing authorization is a European decision, pricing and reimbursement are national or regional responsibilities. The assessment of benefit and risk by the European Medicines Agency is expected to influence future decisions on price and reimbursement on a national or regional level. Collaborations between regulatory agencies and health technology assessment bodies have been initiated on European and national level to facilitate the use of the European Medicines Agency's benefit risk assessment as basis on which to build the subsequent health technology assessment. The option for combined or joint scientific advice procedures with regulators and health technology assessment bodies on European level or on a national level in several European Member States may help applicants to optimize their development program and dossier preparation in regard of both European marketing authorization application and reimbursement decisions.

  17. Comparison of ISO 9000 and recent software life cycle standards to nuclear regulatory review guidance

    Energy Technology Data Exchange (ETDEWEB)

    Preckshot, G.G.; Scott, J.A.

    1998-01-20

    Lawrence Livermore National Laboratory is assisting the Nuclear Regulatory Commission with the assessment of certain quality and software life cycle standards to determine whether additional guidance for the U.S. nuclear regulatory context should be derived from the standards. This report describes the nature of the standards and compares the guidance of the standards to that of the recently updated Standard Review Plan.

  18. Effects of Regulatory Self-Questioning on Secondary-Level Students' Problem-Solving Performance

    Science.gov (United States)

    Pate, Michael L.; Miller, Greg

    2011-01-01

    A randomized posttest-only control group experimental design was used to determine the effects of regulatory self-questioning on secondary-level career and technical education students' electrical circuit theory test scores. Students who participated in the self-questioning group were asked to answer a list of regulatory questions as they solved…

  19. A Preliminary Jupiter Model

    CERN Document Server

    Hubbard, W B

    2016-01-01

    In anticipation of new observational results for Jupiter's axial moment of inertia and gravitational zonal harmonic coefficients from the forthcoming Juno orbiter, we present a number of preliminary Jupiter interior models. We combine results from ab initio computer simulations of hydrogen-helium mixtures, including immiscibility calculations, with a new nonperturbative calculation of Jupiter's zonal harmonic coefficients, to derive a self-consistent model for the planet's external gravity and moment of inertia. We assume helium rain modified the interior temperature and composition profiles. Our calculation predicts zonal harmonic values to which measurements can be compared. Although some models fit the observed (pre-Juno) second- and fourth-order zonal harmonics to within their error bars, our preferred reference model predicts a fourth-order zonal harmonic whose absolute value lies above the pre-Juno error bars. This model has a dense core of about 12 Earth masses, and a hydrogen-helium-rich envelope with...

  20. A Preliminary Jupiter Model

    Science.gov (United States)

    Hubbard, W. B.; Militzer, B.

    2016-03-01

    In anticipation of new observational results for Jupiter's axial moment of inertia and gravitational zonal harmonic coefficients from the forthcoming Juno orbiter, we present a number of preliminary Jupiter interior models. We combine results from ab initio computer simulations of hydrogen-helium mixtures, including immiscibility calculations, with a new nonperturbative calculation of Jupiter's zonal harmonic coefficients, to derive a self-consistent model for the planet's external gravity and moment of inertia. We assume helium rain modified the interior temperature and composition profiles. Our calculation predicts zonal harmonic values to which measurements can be compared. Although some models fit the observed (pre-Juno) second- and fourth-order zonal harmonics to within their error bars, our preferred reference model predicts a fourth-order zonal harmonic whose absolute value lies above the pre-Juno error bars. This model has a dense core of about 12 Earth masses and a hydrogen-helium-rich envelope with approximately three times solar metallicity.

  1. Re-evaluation of Non-regulatory Asbestos Group Minerals for Regulatory Agencies

    Science.gov (United States)

    Dogan, M.; Dogan, A.

    2013-05-01

    There are established rules and regulations for some asbestos group minerals - amphibole group minerals of actinolite, amosite, anthophyllite, crocidolite, tremolite; and serpentine group minerals of chrysotile- called "regulatory". There are also "non-regulatory" naturally occurring asbestos (NOA) group minerals as constituent of rocks and soil, including richterite, winchite, fluoro-edenite, balangeroite, carlosturanite, gageite, arfvedsonite, and magnesio-arfvedsonite. Strong evidences for carcinogenicity of these NOA minerals in later cohorts of cancer patients demonstrated the risks associated with these minerals. In addition, although the chrysotile asbestos regulated by some organizations such as WHO, World Trade Organization, United Nations, US EPA, International Labour Organization, and EU Countries; however, controversies still continue surrounding the use of chrysotile. Determinations of polymineralic fibrous veins, mixed particles, amphibole cleavage fragments, and genetic predisposition are also important issues (i.e. Dogan et al., 2006).Therefore, accurate characterizations of chemical composition, morphology, structure, and defects are necessary in order to find out mechanism(s) of carcinogenicity of all asbestos group minerals. Calculation methods of chemical composition are still under debate because of assumption of no vacancies at any sites and intergrowth of minerals. Substitution(s) may cause deviations from the ideal chemical formula and wide variations in chemical compositions. Detail morphological and chemical quantification of individual asbestos group minerals in micro- and nano-scale may help to evaluate its true carcinogenetic mechanism(s), and consequently prevention and possibly treatment of related diseases. we propose that nonregulatory asbestos minerals and the chrysotile should be re-evaluated. The amount of fibers inhaled, in terms of weight percent and number, need also be re-evaluated by mineralogists. Finally, Regulatory

  2. The Political Economy of Regulatory Risk

    OpenAIRE

    Roland Strausz

    2009-01-01

    I investigate the argument that, in a two–party system with different regulatory objectives, political uncertainty generates regulatory risk. I show that this risk has a fluctuation effect that hurts both parties and an output–expansion effect that benefits one party. Consequently, at least one party dislikes regulatory risk. Moreover, both political parties gain from eliminating regulatory risk when political divergence is small or the winning probability of the regulatory–risk–averse party ...

  3. The political economy of regulatory risk

    OpenAIRE

    Strausz, Roland

    2009-01-01

    I investigate the argument that, in a twoparty system with different regulatory objectives, political uncertainty generates regulatory risk. I show that this risk has a fluctuation effect that hurts both parties and an outputexpansion effect that benefits one party. Consequently, at least one party dislikes regulatory risk. Moreover, both political parties gain from eliminating regulatory risk when political divergence is small or the winning probability of the regulatoryriskaverse party is n...

  4. Nuclear Regulatory Commission 1989 Information Digest

    Energy Technology Data Exchange (ETDEWEB)

    None,

    1989-03-01

    The Nuclear Regulatory Commission 1989 Information Digest provides summary information regarding the US Nuclear Regulatory Commission, its regulatory responsibilities, and areas licensed by the Commission. This is the first of an annual publication for the general use of the NRC staff and is available to the public. The Digest is divided into two parts: the first presents an overview of the US Nuclear Regulatory Commission and the second provides data on NRC commercial nuclear reactor licensees and commercial nuclear power reactors worldwide.

  5. 75 FR 60723 - Seamless Refined Copper Pipe and Tube From Mexico: Final Determination of Sales at Less Than Fair...

    Science.gov (United States)

    2010-10-01

    ... Determination, 75 FR 26726 (May 12, 2010) (``Preliminary Determination).\\1\\ We selected the following companies... Fair Value 75 FR 29990 (May 28, 2010) and Postponement of Final Determination to correct the Scope section of the Preliminary Determination. See Preliminary Determination, 75 FR at 26726. As provided...

  6. Canalization and symmetry in Boolean models for genetic regulatory networks

    Energy Technology Data Exchange (ETDEWEB)

    Reichhardt, C J Olson [Theoretical Division and Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Bassler, Kevin E [Department of Physics, University of Houston, Houston, TX 77204-5005 (United States)

    2007-04-20

    Canalization of genetic regulatory networks has been argued to be favoured by evolutionary processes due to the stability that it can confer to phenotype expression. We explore whether a significant amount of canalization and partial canalization can arise in purely random networks in the absence of evolutionary pressures. We use a mapping of the Boolean functions in the Kauffman N-K model for genetic regulatory networks onto a k-dimensional Ising hypercube (where k = K) to show that the functions can be divided into different classes strictly due to geometrical constraints. The classes can be counted and their properties determined using results from group theory and isomer chemistry. We demonstrate that partially canalizing functions completely dominate all possible Boolean functions, particularly for higher k. This indicates that partial canalization is extremely common, even in randomly chosen networks, and has implications for how much information can be obtained in experiments on native state genetic regulatory networks.

  7. DRUG REGULATORY STATUS ASSIGNMENT CRITERIA: A CONTRAST AMONG 2 COUNTRIES

    Directory of Open Access Journals (Sweden)

    Anoop Paruchuri*, Vini Pavithran , M. Pavani , S. Selvamuthukumaran and G. P. Mohanta

    2013-01-01

    Full Text Available After a laborious and extravagant procedure the drug finally enters the market for use. But who determines the new drug status as a prescription only or an OTC? There is a clear cut contrast between the US and India with respect to their assignment guidelines and the future prospect of a new drug. In the US the regulatory status of the approved drug is determined as per the FDA guidelines (FDCA of 1938 in accordance with the Durham-Humphrey act of 1951 which depicts the criteria required for a pharmaceutical product to be marketed as a prescription drug or an OTC product. CDSCO headed by the DCGI is the authority responsible for determining the regulatory status which acts as per the regulations listed in Drugs and Cosmetics Act of 1940 in India. The US regulatory system stipulates the malleability for the inter conversion of the drugs regulatory status known as “Rx to OTC switch” which is deficient in India. Perfect implementation of regulations in India will promote effective use of OTC’s and forestall illicit sale of prescription drugs as OTC’s.

  8. 21 CFR 500.88 - Regulatory method.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Regulatory method. 500.88 Section 500.88 Food and... § 500.88 Regulatory method. (a) The sponsor shall submit for evaluation and validation a regulatory method developed to monitor compliance with FDA's operational definition of no residue. (b)...

  9. 77 FR 10351 - Regulatory Review Plan

    Science.gov (United States)

    2012-02-22

    ... XII Regulatory Review Plan AGENCY: Federal Housing Finance Agency. ACTION: Notice of final regulatory review plan. SUMMARY: The Federal Housing Finance Agency (FHFA) is issuing a notice of the final FHFA regulatory review plan for review of existing regulations under Executive Order 13579, ``Regulation...

  10. Regulatory Status of Dissimilar Metal Weld (DMW)

    Energy Technology Data Exchange (ETDEWEB)

    Kim, K. C.; Hong, J. K.; Shin, H. S.; Kang, S. S.; Song, M. H.; Chung, H. D. [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2009-05-15

    In this technical article, the regulatory status for Dissimilar Metal Water (DMW) was discussed. In order to decide the regulatory direction of DMW, the USA's accidents of PWSCC and their regulatory directions were reviewed. By reviewing their experiences, the Korean DMW regulation approach was decided.

  11. 40 CFR 94.6 - Regulatory structure.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Regulatory structure. 94.6 Section 94... for Compression-Ignition Marine Engines § 94.6 Regulatory structure. This section provides an overview of the regulatory structure of this part. (a) The regulations of this Part 94 are intended to...

  12. 40 CFR 92.6 - Regulatory structure.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Regulatory structure. 92.6 Section 92... Regulations for Locomotives and Locomotive Engines § 92.6 Regulatory structure. This section provides an overview of the regulatory structure of this part. (a) The regulations of this part 92 are intended...

  13. Regulatory institutions in liberalised electricity markets

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    The reform of the electricity supply industry is gathering pace in many countries. Independent regulatory agencies and other regulatory bodies have been created, and regulatory responsibilities redefined. This book reviews the evolving institutional structures to regulate the electricity supply industry in IEA member countries. It is the latest in a series of IEA publications on energy market reform.

  14. Genetic flexibility of regulatory networks.

    Science.gov (United States)

    Hunziker, Alexander; Tuboly, Csaba; Horváth, Péter; Krishna, Sandeep; Semsey, Szabolcs

    2010-07-20

    Gene regulatory networks are based on simple building blocks such as promoters, transcription factors (TFs) and their binding sites on DNA. But how diverse are the functions that can be obtained by different arrangements of promoters and TF binding sites? In this work we constructed synthetic regulatory regions using promoter elements and binding sites of two noninteracting TFs, each sensing a single environmental input signal. We show that simply by combining these three kinds of elements, we can obtain 11 of the 16 Boolean logic gates that integrate two environmental signals in vivo. Further, we demonstrate how combination of logic gates can result in new logic functions. Our results suggest that simple elements of transcription regulation form a highly flexible toolbox that can generate diverse functions under natural selection.

  15. Regulatory T Cells and Parasites

    Directory of Open Access Journals (Sweden)

    TP. Velavan

    2011-01-01

    Full Text Available Human host encounters a wide array of parasites; however, the crucial aspect is the failure of the host immune system to clear these parasites despite antigen recognition. In the recent past, a new immunological concept has emerged, which provides a framework to better understand several aspects of host susceptibility to parasitic infection. It is widely believed that parasites are able to modulate the magnitude of effector responses by inducing regulatory T cell (Tregs population and several studies have investigated whether this cell population plays a role in balancing protective immunity and pathogenesis during parasite infection. This review discusses the several mechanism of Treg-mediated immunosuppression in the human host and focuses on the functional role of Tregs and regulatory gene polymorphisms in infectious diseases.

  16. Reconsidering Styles of Regulatory Enforcement

    DEFF Research Database (Denmark)

    May, Peter J.; Winter, Søren

    2000-01-01

    This study addresses enforcement styles of regulatory inspectors, based on an examination of the municipal enforcement of agro-environmental policies in Denmark. Our findings make three contributions to the regulatory literature. One contribution is to add empirical support for theorizing about...... inspectors’ enforcement styles as consisting of multiple components, rather than a single continuum. We show that inspectors’ enforcement styles comprise the degree of formalism and the degree of coercion that they exercise when carrying out inspections. A second contribution is in showing the relationship...... of different types of enforcement styles to the two underlying dimensions of the concept. A third contribution is an examination of the ways in which inspectors’ enforcement styles relate to their enforcement actions. The consistency of our findings with those of other studies suggests that the dimensions...

  17. Thermal energy storage in aquifiers: preliminary information

    Energy Technology Data Exchange (ETDEWEB)

    Allen, R.D.

    1979-12-01

    Topics discussed include: conceptual designs; numerical modelling; field experiments; relevant technical information; feasibility studies; preliminary aquifer selection considerations; and preliminary design and operating considerations. (TFD)

  18. 76 FR 7762 - Drinking Water: Regulatory Determination on Perchlorate

    Science.gov (United States)

    2011-02-11

    ... (people with thyroid disorders, pregnant women, fetuses, and infants). EPA's Integrated Risk Information... likely to have adverse effects in sensitive populations (people with thyroid disorders, pregnant women.... 81. p. 563-570. Zimmerman, M. 2009. Iodide Deficiency. Endocrine Reviews. Vol. 30, No. 4. p. 376-408...

  19. Bioattractors: dynamical systems theory and the evolution of regulatory processes.

    Science.gov (United States)

    Jaeger, Johannes; Monk, Nick

    2014-06-01

    In this paper, we illustrate how dynamical systems theory can provide a unifying conceptual framework for evolution of biological regulatory systems. Our argument is that the genotype-phenotype map can be characterized by the phase portrait of the underlying regulatory process. The features of this portrait--such as attractors with associated basins and their bifurcations--define the regulatory and evolutionary potential of a system. We show how the geometric analysis of phase space connects Waddington's epigenetic landscape to recent computational approaches for the study of robustness and evolvability in network evolution. We discuss how the geometry of phase space determines the probability of possible phenotypic transitions. Finally, we demonstrate how the active, self-organizing role of the environment in phenotypic evolution can be understood in terms of dynamical systems concepts. This approach yields mechanistic explanations that go beyond insights based on the simulation of evolving regulatory networks alone. Its predictions can now be tested by studying specific, experimentally tractable regulatory systems using the tools of modern systems biology. A systematic exploration of such systems will enable us to understand better the nature and origin of the phenotypic variability, which provides the substrate for evolution by natural selection.

  20. Regulatory Changes in Depository Institutions

    OpenAIRE

    Yang, Brian Sejoon

    2016-01-01

    In this dissertation we investigate the effect of monetary policy and regulatory changes on asset pricing and investor behavior. In the first chapter, using unique data on over-the-counter bank stock prices and balance sheet information from 1940 to 1968, we find that the largest commercial bank stocks, ranked by market value or gross deposits, have significant lower risk-adjusted annual returns than do small sized bank stocks even after controlling for standard risk factors including size. ...

  1. Escherichia coli transcriptional regulatory network

    Directory of Open Access Journals (Sweden)

    Agustino Martinez-Antonio

    2011-06-01

    Full Text Available Escherichia coli is the most well-know bacterial model about the function of its molecular components. In this review are presented several structural and functional aspects of their transcriptional regulatory network constituted by transcription factors and target genes. The network discussed here represent to 1531 genes and 3421 regulatory interactions. This network shows a power-law distribution with a few global regulators and most of genes poorly connected. 176 of genes in the network correspond to transcription factors, which form a sub-network of seven hierarchical layers where global regulators tend to be set in superior layers while local regulators are located in the lower ones. There is a small set of proteins know as nucleoid-associated proteins, which are in a high cellular concentrations and reshape the nucleoid structure to influence the running of global transcriptional programs, to this mode of regulation is named analog regulation. Specific signal effectors assist the activity of most of transcription factors in E. coli. These effectors switch and tune the activity of transcription factors. To this type of regulation, depending of environmental signals is named the digital-precise-regulation. The integration of regulatory programs have place in the promoter region of transcription units where it is common to observe co-regulation among global and local TFs as well as of TFs sensing exogenous and endogenous conditions. The mechanistic logic to understand the harmonious operation of regulatory programs in the network should consider the globalism of TFs, their signal perceived, coregulation, genome position, and cellular concentration. Finally, duplicated TFs and their horizontal transfer influence the evolvability of members of the network. The most duplicated and transferred TFs are located in the network periphery.

  2. 77 FR 1524 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving...

    Science.gov (United States)

    2012-01-10

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving..., 2011, the Financial Industry Regulatory Authority, Inc. (``FINRA'') filed with the Securities and... effective date of the proposed rule change in a Regulatory Notice to be published no later than 60...

  3. 78 FR 54359 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing...

    Science.gov (United States)

    2013-09-03

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing and... Rule 19b-4 thereunder,\\2\\ notice is hereby given that on August 20, 2103, Financial Industry Regulatory.... \\3\\ 15 U.S.C. 78s(b)(3)(A)(i). \\4\\ 17 CFR 240.19b-4(f)(1). ] I. Self-Regulatory...

  4. 78 FR 10655 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving a...

    Science.gov (United States)

    2013-02-14

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving a...) February 8, 2013. I. Introduction On December 20, 2012, Financial Industry Regulatory Authority, Inc... Equity Securities.\\5\\ FINRA may impose a ``Foreign Regulatory Halt'' when a foreign securities...

  5. 77 FR 33527 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

    Science.gov (United States)

    2012-06-06

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of... hereby given that on May 23, 2012, Financial Industry Regulatory Authority, Inc. (``FINRA'') filed with.... 78s(b)(1). \\2\\ 17 CFR 240.19b-4. I. Self-Regulatory Organization's Statement of the Terms of...

  6. 77 FR 12092 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

    Science.gov (United States)

    2012-02-28

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...\\ notice is hereby given that February 9, 2012, Financial Industry Regulatory Authority, Inc. (``FINRA... interested persons. \\1\\ 15 U.S.C. 78s(b)(1). \\2\\ 17 CFR 240.19b-4. I. Self-Regulatory...

  7. 75 FR 28841 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

    Science.gov (United States)

    2010-05-24

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of... thereunder,\\2\\ notice is hereby given that on May 18, 2010, Financial Industry Regulatory Authority, Inc.... \\1\\ 15 U.S.C. 78s(b)(1). \\2\\ 17 CFR 240.19b-4. I. Self-Regulatory Organization's Statement of...

  8. 76 FR 2739 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing...

    Science.gov (United States)

    2011-01-14

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing and... is hereby given that on January 5, 2011, the Financial Industry Regulatory Authority, Inc. (``FINRA...-Regulatory Organization's Statement of the Terms of Substance of the Proposed Rule Change FINRA is...

  9. 76 FR 20065 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing...

    Science.gov (United States)

    2011-04-11

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing and... Rule 19b-4 thereunder,\\2\\ notice is hereby given that on March 30, 2011, Financial Industry Regulatory... interested persons. \\1\\ 15 U.S.C. 78s(b)(1). \\2\\ 17 CFR 240.19b-4. I. Self-Regulatory...

  10. 75 FR 49542 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

    Science.gov (United States)

    2010-08-13

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of... 19b-4 thereunder,\\2\\ notice is hereby given that on July 27, 2010, Financial Industry Regulatory... from interested persons. \\1\\ 15 U.S.C. 78s(b)(1). \\2\\ 17 CFR 240.19b-4. I. Self-Regulatory...

  11. 76 FR 70195 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

    Science.gov (United States)

    2011-11-10

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...,\\2\\ notice is hereby given that on October 28, 2011, Financial Industry Regulatory Authority, Inc.... \\1\\ 15 U.S.C. 78s(b)(1). \\2\\ 17 CFR 240.19b-4. I. Self-Regulatory Organization's Statement of...

  12. 78 FR 42581 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing...

    Science.gov (United States)

    2013-07-16

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing and... thereunder,\\2\\ notice is hereby given that on June 27, 2013, Financial Industry Regulatory Authority, Inc.... 78s(b)(3)(A)(i). \\4\\ 17 CFR 240.19b-4(f)(1). I. Self-Regulatory Organization's Statement of the...

  13. 77 FR 12098 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

    Science.gov (United States)

    2012-02-28

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of... February 9, 2012, Financial Industry Regulatory Authority, Inc. (``FINRA'') filed with the Securities and...). \\2\\ 17 CFR 240.19b-4. I. Self-Regulatory Organization's Statement of the Terms of Substance of...

  14. 76 FR 72463 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

    Science.gov (United States)

    2011-11-23

    ...-FINRA-2011-044] Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of... is hereby given that on November 8, 2011, Financial Industry Regulatory Authority, Inc. (``FINRA...\\ 15 U.S.C. 78s(b)(1). \\2\\ 17 CFR 240.19b-4. I. Self-Regulatory Organization's Statement of the...

  15. 76 FR 9840 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

    Science.gov (United States)

    2011-02-22

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of... that on February 4, 2011, the Financial Industry Regulatory Authority, Inc. (``FINRA'') filed with the.... 78s(b)(1). \\2\\ 17 CFR 240.19b-4. I. Self-Regulatory Organization's Statement of the Terms of...

  16. 78 FR 78451 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

    Science.gov (United States)

    2013-12-26

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of... thereunder,\\2\\ notice is hereby given that on December 9, 2013, Financial Industry Regulatory Authority, Inc.... \\1\\ 15 U.S.C. 78s(b)(1). \\2\\ 17 CFR 240.19b-4. I. Self-Regulatory Organization's Statement of...

  17. 78 FR 25331 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of...

    Science.gov (United States)

    2013-04-30

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Withdrawal.... On January 7, 2013, Financial Industry Regulatory Authority, Inc. (``FINRA'') filed with the... Regulatory Policy, Wells Fargo Advisors, LLC, dated Feb. 15, 2013; Letter from Tamara K. Salmon,...

  18. 76 FR 67787 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

    Science.gov (United States)

    2011-11-02

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of... thereunder,\\2\\ notice is hereby given that on October 13, 2011, Financial Industry Regulatory Authority, Inc.... 78s(b)(1). \\2\\ 17 CFR 240.19b-4. I. Self-Regulatory Organization's Statement of the Terms of...

  19. 78 FR 76341 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

    Science.gov (United States)

    2013-12-17

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of... thereunder,\\2\\ notice is hereby given that, on December 2, 2013, Financial Industry Regulatory Authority, Inc... considers the subscriber's financial condition and its regulatory history. FINRA believes that the...

  20. 75 FR 2899 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving...

    Science.gov (United States)

    2010-01-19

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving... January 12, 2010. On November 24, 2009, the Financial Industry Regulatory Authority, Inc. (``FINRA'') (f/k...- regulatory organizations.\\6\\ \\6\\ See, e.g., Nasdaq Rule 4761 and NYSE-Arca Rule 7.39. It is therefore...

  1. 78 FR 24261 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing...

    Science.gov (United States)

    2013-04-24

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing and... Rule 19b-4 thereunder,\\2\\ notice is hereby given that on April 15, 2013, Financial Industry Regulatory...\\ 17 CFR 240.19b-4(f)(6). I. Self-Regulatory Organization's Statement of the Terms of Substance of...

  2. 75 FR 7532 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing...

    Science.gov (United States)

    2010-02-19

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing and...,\\2\\ notice is hereby given that on February 4, 2010, Financial Industry Regulatory Authority, Inc... in Regulatory Notice 09-71 that the new financial responsibility rules will be implemented...

  3. 77 FR 58880 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing...

    Science.gov (United States)

    2012-09-24

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing and...,\\2\\ notice is hereby given that on September 17, 2012, Financial Industry Regulatory Authority, Inc...\\ 15 U.S.C. 78s(b)(3)(A). \\4\\ 17 CFR 240.19b-4(f)(6). I. Self-Regulatory Organization's Statement...

  4. 75 FR 58004 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

    Science.gov (United States)

    2010-09-23

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of... is hereby given that on September 7, 2010, Financial Industry Regulatory Authority, Inc. (``FINRA... Securities Exchange, LLC, Financial Industry Regulatory Authority, Inc., The New York Stock Exchange,...

  5. 76 FR 78706 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving a...

    Science.gov (United States)

    2011-12-19

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving a... On October 20, 2011, the Financial Industry Regulatory Authority, Inc. (``FINRA'') filed with the... advised that it would announce the implementation date of the proposed rule change in a Regulatory...

  6. 75 FR 9459 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

    Science.gov (United States)

    2010-03-02

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of... hereby given that Financial Industry Regulatory Authority, Inc. (``FINRA'') (f/k/a National Association... National Association of Securities Dealers, Inc., the Financial Industry Regulatory Authority, Inc., or...

  7. 75 FR 39069 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

    Science.gov (United States)

    2010-07-07

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of... Rule 19b-4 thereunder,\\2\\ notice is hereby given that on June 30, 2010, Financial Industry Regulatory.... \\1\\ 15 U.S.C. 78s(b)(1). \\2\\ 17 CFR 240.19b-4. I. Self-Regulatory Organization's Statement of...

  8. 77 FR 33537 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

    Science.gov (United States)

    2012-06-06

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of... is hereby given that on May 24, 2012, Financial Industry Regulatory Authority, Inc. (``FINRA'') filed.... 78s(b)(1). \\2\\ 17 CFR 240.19b-4. I. Self-Regulatory Organization's Statement of the Terms of...

  9. 78 FR 75954 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

    Science.gov (United States)

    2013-12-13

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of... thereunder,\\2\\ notice is hereby given that on November 25, 2013, Financial Industry Regulatory Authority, Inc.... \\1\\ 15 U.S.C. 78s(b)(1). \\2\\ 17 CFR 240.19b-4. I. Self-Regulatory Organization's Statement of...

  10. 75 FR 69503 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

    Science.gov (United States)

    2010-11-12

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...\\ notice is hereby given that on October 29, 2010, Financial Industry Regulatory Authority, Inc. (``FINRA.... 78s(b)(1). \\2\\ 17 CFR 240.19b-4. I. Self-Regulatory Organization's Statement of the Terms of...

  11. 75 FR 15470 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing...

    Science.gov (United States)

    2010-03-29

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing and... thereunder,\\2\\ notice is hereby given that, on March 9, 2010, Financial Industry Regulatory Authority, Inc...-Regulatory Organization's Statement of the Terms of Substance of the Proposed Rule Change FINRA is...

  12. 75 FR 53998 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing...

    Science.gov (United States)

    2010-09-02

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing and... Rule 19b-4 thereunder,\\2\\ notice is hereby given that on August 16, 2010, Financial Industry Regulatory.... \\1\\ 15 U.S.C. 78s(b)(1). \\2\\ 17 CFR 240.19b-4. I. Self-Regulatory Organization's Statement of...

  13. 77 FR 5611 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving a...

    Science.gov (United States)

    2012-02-03

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving a..., 2012. I. Introduction On October 13, 2011, the Financial Industry Regulatory Authority, Inc. (``FINRA... change in a Regulatory Notice to be published no later than 90 days following Commission approval,...

  14. 76 FR 66344 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving...

    Science.gov (United States)

    2011-10-26

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving.... Introduction On August 31, 2011, Financial Industry Regulatory Authority, Inc. (``FINRA'') (f/k/a National... Regulatory Notice to be published no later than 90 days following this Commission approval. The...

  15. 75 FR 62901 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing...

    Science.gov (United States)

    2010-10-13

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing and... thereunder,\\2\\ notice is hereby given that on September 27, 2010, the Financial Industry Regulatory Authority....19b-4(f)(6). I. Self-Regulatory Organization's Statement of the Terms of Substance of the...

  16. 76 FR 50515 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing...

    Science.gov (United States)

    2011-08-15

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing and... Rule 19b-4 thereunder,\\2\\ notice is hereby given that on August 5, 2011, Financial Industry Regulatory...-4(f)(6). I. Self-Regulatory Organization's Statement of the Terms of Substance of the Proposed...

  17. 76 FR 65758 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

    Science.gov (United States)

    2011-10-24

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of... thereunder,\\2\\ notice is hereby given that on October 5, 2011, Financial Industry Regulatory Authority, Inc.... \\1\\ 15 U.S.C. 78s(b)(1). \\2\\ 17 CFR 240.19b-4. I. Self-Regulatory Organization's Statement of...

  18. 75 FR 18245 - Public Federal Regulatory Enforcement Fairness Hearing Region IX Regulatory Fairness Board

    Science.gov (United States)

    2010-04-09

    ... ADMINISTRATION Public Federal Regulatory Enforcement Fairness Hearing Region IX Regulatory Fairness Board.... Small Business Administration (SBA) Region IX Regulatory Fairness Board and the SBA Office of the National Ombudsman will hold a National Regulatory Fairness Hearing on Monday, April 26, 2010, at 1:30 p.m...

  19. 78 FR 30384 - Federal Regulatory Enforcement Fairness Hearing; Region X Regulatory Fairness Board

    Science.gov (United States)

    2013-05-22

    ... ADMINISTRATION Federal Regulatory Enforcement Fairness Hearing; Region X Regulatory Fairness Board AGENCY: U.S... Business Regulatory Fairness Board. SUMMARY: The (SBA) Office of the National Ombudsman is issuing this notice to announce the location, date and time of the Regional Small Business Regulatory Fairness hearing...

  20. 75 FR 17793 - Public Federal Regulatory Enforcement Fairness Hearing; Region III Regulatory Fairness Board

    Science.gov (United States)

    2010-04-07

    ... ADMINISTRATION Public Federal Regulatory Enforcement Fairness Hearing; Region III Regulatory Fairness Board.... Small Business Administration (SBA) Region III Regulatory Fairness Board and the SBA Office of the National Ombudsman will hold a National Regulatory Fairness Hearing on Tuesday, May 18, 2010, at 10 a.m...

  1. 78 FR 36011 - Region VII Regulatory Fairness Board; Federal Regulatory Enforcement Fairness Hearing

    Science.gov (United States)

    2013-06-14

    ... ADMINISTRATION Region VII Regulatory Fairness Board; Federal Regulatory Enforcement Fairness Hearing AGENCY: U.S... Business Regulatory Fairness Board. SUMMARY: The (SBA) Office of the National Ombudsman is issuing this notice to announce the location, date and time of the Regional Small Business Regulatory Fairness hearing...

  2. Followers feel valued : When leaders' regulatory focus makes leaders exhibit behavior that fits followers' regulatory focus

    NARCIS (Netherlands)

    Hamstra, Melvyn; Sassenberg, K.; Van Yperen, Nico W.; Wisse, Barbara

    2014-01-01

    When do followers feel valued by their leader? We propose that leaders' regulatory focus can make followers feel valued when leaders' regulatory focus is the same as followers' regulatory focus, that is, when there is regulatory fit between leaders and followers. We further propose that the reason w

  3. 75 FR 11166 - Joint Meeting of the Nuclear Regulatory Commission and the Federal Energy Regulatory Commission...

    Science.gov (United States)

    2010-03-10

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Joint Meeting of the Nuclear Regulatory Commission and the Federal Energy Regulatory Commission; Notice of Joint Meeting of the Nuclear Regulatory Commission and the...

  4. Preliminary Iron Distribution on Vesta

    Science.gov (United States)

    Mittlefehldt, David W.; Mittlefehldt, David W.

    2013-01-01

    The distribution of iron on the surface of the asteroid Vesta was investigated using Dawn's Gamma Ray and Neutron Detector (GRaND) [1,2]. Iron varies predictably with rock type for the howardite, eucrite, and diogenite (HED) meteorites, thought to be representative of Vesta. The abundance of Fe in howardites ranges from about 12 to 15 wt.%. Basaltic eucrites have the highest abundance, whereas, lower crustal and upper mantle materials (cumulate eucrites and diogenites) have the lowest, and howardites are intermediate [3]. We have completed a mapping study of 7.6 MeV gamma rays produced by neutron capture by Fe as measured by the bismuth germanate (BGO) detector of GRaND [1]. The procedures to determine Fe counting rates are presented in detail here, along with a preliminary distribution map, constituting the necessary initial step to quantification of Fe abundances. We find that the global distribution of Fe counting rates is generally consistent with independent mineralogical and compositional inferences obtained by other instruments on Dawn such as measurements of pyroxene absorption bands by the Visual and Infrared Spectrometer (VIR) [4] and Framing Camera (FC) [5] and neutron absorption measurements by GRaND [6].

  5. Complex Unsaturated Zone Flow and Thermohydrologic Processes in a Regulatory Environment: A Perspective on Uncertainty

    Science.gov (United States)

    Fedors, R. W.; Manepally, C.; Justus, P. S.; Basagaoglu, H.; Pensado, O.; Dubreuilh, P.

    2007-12-01

    with convection along drifts and air flow through fractures, (v) effect of the thermal perturbation caused by radioactive waste, and (vi) consideration of drift stability and climate change because of the long time periods of interest-I 0,000 to a million years. This poster tracks the available information starting from site characterization and continuing on to abstractions used in performance assessment models. At each step, multiple interpretations or alternatives can be identified based on fundamental observations and measurements. From a regulatory perspective, confidence is gained when alternative models or abstractions lead to similar results from a performance assessment; otherwise uncertainty from alternative explanations should be considered in terms of a defendable review. This abstract is an independent product of the CNWRA and does not necessarily reflect the views or regulatory positions of the NRC. The NRC staff views expressed herein are preliminary and do not constitute a final judgment or determination of the matters addressed or of the acceptability of a license application for a geologic repository at Yucca Mountain.

  6. 77 FR 40354 - Mesa de Los Carros Hydro, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2012-07-09

    ... Energy Regulatory Commission Mesa de Los Carros Hydro, LLC; Notice of Preliminary Permit Application..., 2012, Mesa De Los Carros Hydro, LLC filed an application, pursuant to section 4(f) of the Federal Power Act (FPA), proposing to study the feasibility of the Mesa De Los Carros Pumped Storage Project to...

  7. 75 FR 66083 - Iron Mask Hydro, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Science.gov (United States)

    2010-10-27

    ... Federal Energy Regulatory Commission Iron Mask Hydro, LLC; Notice of Preliminary Permit Application..., 2010. On May 6, 2010, and supplemented on July 15, 2010, Iron Mask Hydro, LLC filed an application for... the feasibility of the Iron Mask Pumped Storage Project to be located near the U.S. Bureau...

  8. 75 FR 21289 - Oregon Wave Energy Partners I, LLC; Notice of Preliminary Permit Application Accepted for Filing...

    Science.gov (United States)

    2010-04-23

    ... Energy Regulatory Commission Oregon Wave Energy Partners I, LLC; Notice of Preliminary Permit Application..., 2010. On March 2, 2010, Oregon Wave Energy Partners I, LLC filed an application for a subsequent.... Applicant Contact: Mr. Charles F. Dunleavy, Oregon Wave Energy Partners I, LLC, 1590 Reed Road,...

  9. 78 FR 34092 - Lock+ Hydro Friends Fund XXX, LLC; FFP Project 121, LLC; Notice of Competing Preliminary Permit...

    Science.gov (United States)

    2013-06-06

    ... Energy Regulatory Commission Lock+ Hydro Friends Fund XXX, LLC; FFP Project 121, LLC; Notice of Competing... Competing Applications Lock+ Hydro Friends Fund XXX, LLC and FFP Project 121, LLC filed preliminary permit... 8:30 a.m. on the next regular business day. See id. at 385.2001(a)(2). Lock+ Hydro Friends Fund...

  10. 75 FR 40804 - FFP Missouri 2, LLC; Notice of Preliminary Permit Applications Accepted for Filing and Soliciting...

    Science.gov (United States)

    2010-07-14

    ... Energy Regulatory Commission FFP Missouri 2, LLC; Notice of Preliminary Permit Applications Accepted for..., 2010, FFP Missouri 2, LLC filed an application, pursuant to section 4(f) of the Federal Power Act... FFP Missouri 2, LLC, project would have an average annual generation of 17.5 gigawatt-hours....

  11. 77 FR 31610 - FFP Project 110, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Science.gov (United States)

    2012-05-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission FFP Project 110, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting Comments, Motions To Intervene, and Competing Applications On May 1, 2012, the...

  12. 75 FR 40803 - FFP Missouri 2, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Science.gov (United States)

    2010-07-14

    ... Federal Energy Regulatory Commission FFP Missouri 2, LLC; Notice of Preliminary Permit Application.... On April 5, 2010, FFP Missouri 2, LLC filed an application, pursuant to section 4(f) of the Federal...-phase overhead transmission line; and (7) appurtenant facilities. The FFP Missouri 2, LLC, project...

  13. 78 FR 18335 - FFP Project 121, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Science.gov (United States)

    2013-03-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission FFP Project 121, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting Comments, Motions To Intervene, and Competing Applications On March 1, 2013,...

  14. 77 FR 64331 - City of Burlington, IA; FFP Iowa 5, LLC; Notice of Competing Preliminary Permit Applications...

    Science.gov (United States)

    2012-10-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission City of Burlington, IA; FFP Iowa 5, LLC; Notice of Competing Preliminary... County, Iowa and Henderson County, Illinois. On the same date, FFP Iowa 5, LLC filed an...

  15. 75 FR 78984 - South Run Pumped Storage, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2010-12-17

    ... Energy Regulatory Commission South Run Pumped Storage, LLC; Notice of Preliminary Permit Application..., 2010. On October 26, 2010, South Run Pumped Storage, LLC, Massachusetts, filed an application for a... feasibility of the South Run Pumped Storage Project (South Run Project or project) to be located on South...

  16. 77 FR 73651 - North Star Hydro Services, CA LLC; Notice of Preliminary Permit Application Accepted for Filing...

    Science.gov (United States)

    2012-12-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission North Star Hydro Services, CA LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting Comments, Motions To Intervene, and Competing Applications On November 6, 2012, North Star Hydro Services...

  17. 77 FR 55212 - North Star Hydro Services CA, LLC; Notice of Preliminary Permit Application Accepted for Filing...

    Science.gov (United States)

    2012-09-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission North Star Hydro Services CA, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting Comments, Motions To Intervene, and Competing Applications On March 30, 2012, North Star Hydro Services...

  18. The Preliminaries of a Reference

    DEFF Research Database (Denmark)

    Butler, Graham; Sadl, Urska

    2017-01-01

    by the reasons why the Court after an oral hearing held in the presence of the parties and eight intervening Member States, and after hearing the Advocate General did not deliver one. The comment examines the legal framework, as well as the detailed procedural rules and guidelines that govern the cooperation...... of national courts in the preliminary reference procedure. It highlights the fact that preliminary references can only work when the preliminaries of a reference – the culture of sincere cooperation and litigation, efficient communication and flexible procedural rules – are in place....

  19. Global Regulatory Pathways in the Alphaproteobacteria

    Energy Technology Data Exchange (ETDEWEB)

    none

    2007-04-27

    A major goal for microbiologists in the twenty-first century is to develop an understanding of the microbial cell in all its complexity. In addition to understanding the function of individual gene products we need to focus on how the cell regulates gene expression at a global level to respond to different environmental parameters. Development of genomic technologies such as complete genome sequencing, proteomics, and global comparisons of mRNA expression patterns allows us to begin to address this issue. This proposal focuses on a number of phylogenetically related bacteria that are involved in environmentally important processes such as carbon sequestration and bioremediation. Genome sequencing projects of a number of these bacteria have revealed the presence of a small family of regulatory genes found thus far only in the alpha-proteobacteria. These genes encode proteins that are related to the global regulatory protein RosR in Rhizobium etli, which is involved in determining nodulation competitiveness in this bacterium. Our goal is to examine the function of the proteins encoded by this gene family in several of the bacteria containing homologs to RosR. We will construct gene disruption mutations in a number of these bacteria and characterize the resulting mutant strains using two-dimensional gel electrophoresis and genetic and biochemical techniques. We will thus determine if the other proteins also function as global regulators of gene expression. Using proteomics methods we will identify the specific proteins whose expression varies depending on the presence or absence of the RosR homolog. Over fifty loci regulated by RosR have been identified in R. etli using transposon mutagenesis; this will serve as out benchmark to which we will compare the other regulons. We expect to identify genes regulated by RosR homologs in several bacterial species, including, but not limited to Rhodopseudomonas palustris and Sphingomonas aromaticivorans. In this way we will

  20. 75 FR 28073 - Draft Regulatory Guide: Issuance, Availability

    Science.gov (United States)

    2010-05-19

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory Guide, DG-3039, ``Standard Format and Content...

  1. 75 FR 48382 - Draft Regulatory Guide: Issuance, Availability

    Science.gov (United States)

    2010-08-10

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory Guide, DG-1228, ``Standard Format and Content...

  2. Stochastic Oscillations in Genetic Regulatory Networks: Application to Microarray Experiments

    Directory of Open Access Journals (Sweden)

    Rosenfeld Simon

    2006-01-01

    Full Text Available We analyze the stochastic dynamics of genetic regulatory networks using a system of nonlinear differential equations. The system of -functions is applied to capture the role of RNA polymerase in the transcription-translation mechanism. Using probabilistic properties of chemical rate equations, we derive a system of stochastic differential equations which are analytically tractable despite the high dimension of the regulatory network. Using stationary solutions of these equations, we explain the apparently paradoxical results of some recent time-course microarray experiments where mRNA transcription levels are found to only weakly correlate with the corresponding transcription rates. Combining analytical and simulation approaches, we determine the set of relationships between the size of the regulatory network, its structural complexity, chemical variability, and spectrum of oscillations. In particular, we show that temporal variability of chemical constituents may decrease while complexity of the network is increasing. This finding provides an insight into the nature of "functional determinism" of such an inherently stochastic system as genetic regulatory network.

  3. A PRELIMINARY JUPITER MODEL

    Energy Technology Data Exchange (ETDEWEB)

    Hubbard, W. B. [Lunar and Planetary Laboratory, The University of Arizona, Tucson, AZ 85721 (United States); Militzer, B. [Department of Earth and Planetary Science, Department of Astronomy, University of California, Berkeley, CA 94720 (United States)

    2016-03-20

    In anticipation of new observational results for Jupiter's axial moment of inertia and gravitational zonal harmonic coefficients from the forthcoming Juno orbiter, we present a number of preliminary Jupiter interior models. We combine results from ab initio computer simulations of hydrogen–helium mixtures, including immiscibility calculations, with a new nonperturbative calculation of Jupiter's zonal harmonic coefficients, to derive a self-consistent model for the planet's external gravity and moment of inertia. We assume helium rain modified the interior temperature and composition profiles. Our calculation predicts zonal harmonic values to which measurements can be compared. Although some models fit the observed (pre-Juno) second- and fourth-order zonal harmonics to within their error bars, our preferred reference model predicts a fourth-order zonal harmonic whose absolute value lies above the pre-Juno error bars. This model has a dense core of about 12 Earth masses and a hydrogen–helium-rich envelope with approximately three times solar metallicity.

  4. Preliminary reference Earth model

    Science.gov (United States)

    Dziewonski, Adam M.; Anderson, Don L.

    1981-06-01

    A large data set consisting of about 1000 normal mode periods, 500 summary travel time observations, 100 normal mode Q values, mass and moment of inertia have been inverted to obtain the radial distribution of elastic properties, Q values and density in the Earth's interior. The data set was supplemented with a special study of 12 years of ISC phase data which yielded an additional 1.75 × 10 6 travel time observations for P and S waves. In order to obtain satisfactory agreement with the entire data set we were required to take into account anelastic dispersion. The introduction of transverse isotropy into the outer 220 km of the mantle was required in order to satisfy the shorter period fundamental toroidal and spheroidal modes. This anisotropy also improved the fit of the larger data set. The horizontal and vertical velocities in the upper mantle differ by 2-4%, both for P and S waves. The mantle below 220 km is not required to be anisotropic. Mantle Rayleigh waves are surprisingly sensitive to compressional velocity in the upper mantle. High S n velocities, low P n velocities and a pronounced low-velocity zone are features of most global inversion models that are suppressed when anisotropy is allowed for in the inversion. The Preliminary Reference Earth Model, PREM, and auxiliary tables showing fits to the data are presented.

  5. Estudio preliminar sobre la determinación de elementos traza en cervezas venezolanas por ICP-OES Preliminary study on the determination of trace elements in venezuelan beers by ICP-OES

    Directory of Open Access Journals (Sweden)

    Eunice Marcano

    2010-01-01

    Full Text Available The levels of several chemical elements were determined simultaneously in ten different beers of the Venezuelan market by ICP-OES. With the exception of chromium, beer does not provide important amounts of nutritional oligoelements. The average chromium content found (33 µg/L is higher than one reported for USA's beer (10 µg/L but smaller than another reported for Brazilian beer (66 µg/L. The average percentage of chromium RDA by beer consumption found for Venezuela (6.3% is similar to that reported for Belgium (5%. Regarding toxic elements, one of the samples contained an elevated amount of aluminium, probably dissolved from the aluminium can.

  6. Arapahoe NWR diversion reconstruction : Preliminary

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This is a preliminary plan for a diversion reconstruction for Hubbard #2. Oklahoma #1, Dryer, Hill and Crowder sites on the Arapahoe National Wildlife Refuge.

  7. Defining Tobacco Regulatory Science Competencies.

    Science.gov (United States)

    Wipfli, Heather L; Berman, Micah; Hanson, Kacey; Kelder, Steven; Solis, Amy; Villanti, Andrea C; Ribeiro, Carla M P; Meissner, Helen I; Anderson, Roger

    2017-02-01

    In 2013, the National Institutes of Health and the Food and Drug Administration funded a network of 14 Tobacco Centers of Regulatory Science (TCORS) with a mission that included research and training. A cross-TCORS Panel was established to define tobacco regulatory science (TRS) competencies to help harmonize and guide their emerging educational programs. The purpose of this paper is to describe the Panel's work to develop core TRS domains and competencies. The Panel developed the list of domains and competencies using a semistructured Delphi method divided into four phases occurring between November 2013 and August 2015. The final proposed list included a total of 51 competencies across six core domains and 28 competencies across five specialized domains. There is a need for continued discussion to establish the utility of the proposed set of competencies for emerging TRS curricula and to identify the best strategies for incorporating these competencies into TRS training programs. Given the field's broad multidisciplinary nature, further experience is needed to refine the core domains that should be covered in TRS training programs versus knowledge obtained in more specialized programs. Regulatory science to inform the regulation of tobacco products is an emerging field. The paper provides an initial list of core and specialized domains and competencies to be used in developing curricula for new and emerging training programs aimed at preparing a new cohort of scientists to conduct critical TRS research. © The Author 2016. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  8. REGULATORY AGENCIES, CONSUMER AND ENVIROMENT

    Directory of Open Access Journals (Sweden)

    Giseli Valezi Raymundo

    2011-03-01

    Full Text Available The aim of this paper is to present the analysis on the insertion of the consumer in the current model of State in Brazil, considering the nowaday legal system. It is wished to be shown, moreover, the already existing reality on the theme, even if modest, so to in a way to question the responsibility of the consumer, according to its consuming habits and its inertia, takes in today’s technological society. To such proposal, the most effective research method, and, for this reason had been used in this paper, is the extensive bibliography research and legislation consultation. Through it, it had been found that the State model has changed over the past decades in order to delegate the execution of various activities of State ownership to private enterprise, in view of the existence of a minimal State and governor. In this sense, there were created the Regulatory Agencies, which are indirect public administration entities, with the ultimate objective of regulating and supervising the execution of those legal activities, performed by the private sector. The consumer, inserted in this reality, is the direct recipient of the action of the mentioned entities, questioning the legislative and sanction legitimacy of the regulatory entities as well as the possibility of judicial review on the merits of administrative actions of these entities and the applicability of the Brazilian Code of Defense of the Consumer (CDC to the execution of public services, a discipline that affects the administrative law rights. Notwithstanding the above analysis in context, all these social workers, consumers and regulatory agencies are immersed in changing habits, due to the optimization of actions, aimed at preserving the environment, the prospect of achieving sustainable development. Based on this perspective, the results brought by the survey showed that the application of the Brazilian Code of Defense of the Consumer in relations between consumers does not preclude

  9. Preliminary results of determination of chemical changes on Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (W.Curt.:Fr.)P. Karst. (higher Basidiomycetes) carried by Shenzhou I spaceship with FTIR and 2D-IR correlation spectroscopy.

    Science.gov (United States)

    Choong, Yew Keong; Chen, Xiangdong; Jamal, Jamia Azdina; Wang, Qiuying; Lan, Jin

    2012-01-01

    Spaceflight represents a complex environmental condition. Space mutagenesis breeding has achieved marked results over the years. The objective of this study is to determine the chemical changes in medicinal mushroom Ganoderma lucidum cultivated after spaceflight in 1999. Fourier transform infrared (FTIR) and two-dimensional infrared (2DIR) correlation spectroscopy were used in analysis. The sample Sx and its control Cx showed the least dissimilarities in one-dimensional FTIR spectra, but absorbance of Sx is twice as high as Cx. Sx presented a clear peak at 1648 cm in 2nd derivative spectra, which could not be detected in the Cx. The 2DIR spectra showed the intensity of Sx in the range 1800-1400 cm-1 for protein is higher than the control. The sample Sx produced some carbohydrate peaks in the area of 889 cm-1 compared with the Cx. The spaceflight set up an extreme condition and caused changes of chemical properties in G. lucidum strain.

  10. Preliminary Study on the Use of Radionuclides 137{sup C}s and 210{sup P}b and Spectro radiometry Techniques as Tools to Determine Soil Erosion State; Estudio Preliminar sobre el Uso de los Radionucleidos 137{sup C}s y 210{sup P}b y las Tecnicas de Espectrorradiometria como Herramientas para Determinar el Estado de Erosion de Suelos

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez Vegas, E.; Gasco Leonarte, C.; Schmid, T.; Suarez, J. A.; Rodriguez Rastrero, M.; Almorox Alonso, J.

    2013-07-01

    Radionuclides are largely used as tools for studying and quantifying soil erosion. The global fallout of artificial radionuclides derived from weapons testing (1945-1970) was rapidly and firmly fixed in soil surface horizons. This allowed determining soil erosion by comparing 137{sup C}s inventories at individual sampling points with a reference inventory. This procedure is complemented with the 210{sup P}buns inventory calculation as an indicator of the local average of radionuclides deposition. Spectro radiometry is implemented to associate soil reflectance measurements to physical and chemical soil properties related to soil erosion processes obtained from laboratory analyses. The methodology applies both instrumental techniques in soil samples from a semiarid agricultural area near to Camarena (Toledo). The resulting inventories obtained for 137{sup C}s and 210{sup P}bexc are similar to the Spanish reference allowing comparation. Spectro radiometry results correlate well with soil properties measured in the laboratory and can be applied to determine these properties more quickly and easily, as well as for integration with gamma spectrometry results. This is a preliminary study to identify soils affected by erosion that is presented as a Master thesis of the Official Master Degree: {sup A}gro- Environmental Technology for a Sustainable Agriculture{sup ,} of the Technical University of Madrid - School of Agricultural Engineers (UPM-ETSI). Coherent and complimentary results are obtained applying both instrumental techniques within this agricultural area.. (Author)

  11. 76 FR 47558 - Polyethylene Terephthalate Film, Sheet, and Strip From India: Preliminary Results of...

    Science.gov (United States)

    2011-08-05

    ... countervailable subsidies provided on the production and export of PET Film from India. See the ``Preliminary... performance. See PET Film Final Determination at ``Pre-Shipment and Post-Shipment Export Financing.'' There is... International Trade Administration Polyethylene Terephthalate Film, Sheet, and Strip From India: Preliminary...

  12. Regulatory Issues Surrounding Merchant Interconnection

    Energy Technology Data Exchange (ETDEWEB)

    Kuijlaars, Kees-Jan; Zwart, Gijsbert [Office for Energy Regulation (DTe), The Hague (Netherlands)

    2003-11-01

    We discussed various issues concerning the regulatory perspective on private investment in interconnectors. One might claim that leaving investment in transmission infrastructure to competing market parties is more efficient than relying on regulated investment only (especially in the case of long (DC) lines connecting previously unconnected parts of the grids, so that externalities from e.g. loop flows do not play a significant role). We considered that some aspects of interconnection might reduce these market benefits. In particular, the large fixed costs of interconnection construction may lead to significant under investment (due to both first mover monopoly power and the fact that part of generation cost efficiencies realised by interconnection are not captured by the investor itself, and remain external to the investment decision). Second, merchant ownership restricts future opportunities for adaptation of regulation, as would be required e.g. for introduction of potentially more sophisticated methods of congestion management or market splitting. Some of the disadvantages of merchant investment may be mitigated however by a suitable regulatory framework, and we discussed some views in this direction. The issues we discussed are not intended to give a complete framework, and detailed regulation will certainly involve many more specific requirements. Areas we did not touch upon include e.g. the treatment of deep connection costs, rules for operation and maintenance of the line, and impact on availability of capacity on other interconnections.

  13. Endocrine cells producing regulatory peptides.

    Science.gov (United States)

    Solcia, E; Usellini, L; Buffa, R; Rindi, G; Villani, L; Zampatti, C; Silini, E

    1987-07-15

    Recent data on the immunolocalization of regulatory peptides and related propeptide sequences in endocrine cells and tumors of the gastrointestinal tract, pancreas, lung, thyroid, pituitary (ACTH and opioids), adrenals and paraganglia have been revised and discussed. Gastrin, xenopsin, cholecystokinin (CCK), somatostatin, motilin, secretin, GIP (gastric inhibitory polypeptide), neurotensin, glicentin/glucagon-37 and PYY (peptide tyrosine tyrosine) are the main products of gastrointestinal endocrine cells; glucagon, CRF (corticotropin releasing factor), somatostatin, PP (pancreatic polypeptide) and GRF (growth hormone releasing factor), in addition to insulin, are produced in pancreatic islet cells; bombesin-related peptides are the main markers of pulmonary endocrine cells; calcitonin and CGRP (calcitonin gene-related peptide) occur in thyroid and extrathyroid C cells; ACTH and endorphins in anterior and intermediate lobe pituitary cells, alpha-MSH and CLIP (corticotropin-like intermediate lobe peptide) in intermediate lobe cells; met- and leu-enkephalins and related peptides in adrenal medullary and paraganglionic cells as well as in some gut (enterochromaffin) cells; NPY (neuropeptide Y) in adrenaline-type adrenal medullary cells, etc.. Both tissue-appropriate and tissue-inappropriate regulatory peptides are produced by endocrine tumours, with inappropriate peptides mostly produced by malignant tumours.

  14. Dynamic simulation of regulatory networks using SQUAD

    Directory of Open Access Journals (Sweden)

    Xenarios Ioannis

    2007-11-01

    to stimuli, such as drugs, or determine the role of specific components within the network. The predictions can then be used to interpret and/or drive laboratory experiments. SQUAD provides a user-friendly graphical interface, accessible to both computational and experimental biologists for the fast qualitative simulation of large regulatory networks for which kinetic data is not necessarily available.

  15. Determination of in-situ thermal properties of Stripa granite from temperature measurements in the full-scale heater experiments: method and preliminary results. Technical information report No. 24

    Energy Technology Data Exchange (ETDEWEB)

    Jeffry, J.A.; Chan, T.; Cook, N.G.W.; Witherspoon, P.A.

    1979-05-01

    The in-situ thermal conductivity and thermal diffusivity of a granite rock mass at the Stripa mine, Sweden, have been extracted from the first 70 days of temperature data for the 5 kW full-scale heater experiment by means of least-squares fit to a finite-line source solution. Thermal conductivity and thermal diffusivity have been determined to be 3.69 W/(m-/sup 0/C) and 1.84 x 10/sup -6/ m/sup 2//s, respectively, at an average rock temperature of 23/sup 0/C (the average value of the actual temperature data used). These values are only slightly higher than the corresponding laboratory values, i.e., there is no significant size effect in the thermal properties of this rock mass. Since the size and shape of the heater canister used are similar to those considered for nuclear waste canisters and a substantial volume of rock is heated, the thermal properties obtained in this study are representative of in-situ rock mass properties under actual nuclear repository operating conditions.

  16. [Advanced therapy: from European regulatory framework to national regulatory framework].

    Science.gov (United States)

    Lucas-Samuel, S

    2013-05-01

    The European regulation n(o) 1394/2007/CE published on the 13th of November 2007 defined and harmonized the European regulatory framework for advanced therapy medicinal products. It creates a specialized committee located at the European Medicine Agency, in charge of the assessment of these medicinal products. The consequences of this regulation are introduced in the French regulation by the law n(o) 2011-302 published on the 22nd of March 2011. It detailed notably the possibility for public establishments (except health establishments) and nonprofit organisms to create pharmaceutical establishments. This law defined also a specific category of advanced therapy medicinal products, which fall under the "hospital exemption" framework. The rules regarding the authorizations of the establishments able to prepare these types of medicinal products and the authorization of the products are defined by the n(o) 2012-1236 decree published on the 6th of November 2012.

  17. Global Summit on Regulatory Science 2013.

    Science.gov (United States)

    Howard, Paul C; Tong, Weida; Weichold, Frank; Healy, Marion; Slikker, William

    2014-12-01

    Regulatory science has been defined as the science that is used to develop regulatory decisions by government bodies. Regulatory science encompasses many scientific disciplines that oversee many studies producing a wide array of data. These may include fundamental research into the cellular interaction or response to a particular chemical or substance, hazard-assessment and dose-response studies in animal species, neurophysiological or neurobehavioral studies, best practices for the generation and analysis of genomics data, bioinformatics approaches, and mathematical modeling of risk. The Global Summit on Regulatory Science is an international conference with a mission to explore emerging and innovative technologies, and provide a platform to enhance translation of basic science into regulatory applications. The Third Global Summit on Regulatory Science which focused on nanotechnology is discussed.

  18. Regulatory criteria: Legal or ecological thresholds?

    Energy Technology Data Exchange (ETDEWEB)

    Cook, J.M.; Skorupa, J.P.; Schwarzbach, S.E. [Fish and Wildlife Service, Sacramento, CA (United States)

    1994-12-31

    Selenium-laden irrigation drainwater has been identified as a significant threat to breeding waterfowl and shorebirds in terminal sink environments throughout the western United States. Due to historic wetland habitat losses, irrigation drainwater disposal ponds represent virtually all the available breeding habitat for waterbirds in the southern San Joaquin Valley of California. Egg selenium residues from birds breeding at these ponds have been monitored by the US Fish and Wildlife Service since 1987, and physiological risk thresholds for individual and population-level hatchability and teratogenesis have been determined from these studies. For Blacknecked stilt populations, egg selenium below 3 ppm may be considered a safe level, hatchability is significantly depressed at mean egg selenium concentrations above 8 ppm, and induction of teratogenesis is virtually certain at egg selenium levels above 18 ppm (p < 0.05). Egg samples collected in 1993 from these ponds showed concentrations as high as 160 ppm. Despite the high degree of statistical confidence in these effects thresholds, and the incidence of selenium-induced bird death and deformity at these ponds, regulation of evaporation ponds has been problematic. Existing civil statutes regarding water quality are dependent on risk-based criteria, but irrigation drainwater is exempted from these regulations. The only applicable law is the Migratory Bird Treaty Act, a criminal statute with no risk-based guidelines, and consequently no wildlife safety factors. The authors present data from the San Joaquin Valley in the context of these regulatory and legal limitations. Evaluation of acute and chronic models for ambient water quality indicate that this approach may not provide adequate protection for breeding birds. Based on the inadequacy of these models, the authors consider the development of regulatory criteria for egg selenium, a standard which is ecologically relevant.

  19. Environmental Regulatory Update Table, December 1991

    Energy Technology Data Exchange (ETDEWEB)

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1992-01-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  20. Environmental Regulatory Update Table, December 1989

    Energy Technology Data Exchange (ETDEWEB)

    Houlbert, L.M.; Langston, M.E. (Tennessee Univ., Knoxville, TN (USA)); Nikbakht, A.; Salk, M.S. (Oak Ridge National Lab., TN (USA))

    1990-01-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  1. Regulatory Risk under Optimal Incentive Regulation

    OpenAIRE

    Strausz, Roland

    2009-01-01

    The paper provides a tractable, analytical framework to study regulatory risk under optimal incentive regulation. Regulatory risk is captured by uncertainty about the policy variables in the regulator’s objective function: weights attached to profits and costs of public funds. Results are as follows: 1) The regulator’s reaction to regulatory risk depends on the curvature of the aggregate demand function. 2) It yields a positive information rent effect exactly when demand is convex. 3) Firms b...

  2. Environmental Regulatory Update Table, November 1991

    Energy Technology Data Exchange (ETDEWEB)

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1991-12-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  3. Environmental Regulatory Update Table, August 1991

    Energy Technology Data Exchange (ETDEWEB)

    Houlberg, L.M., Hawkins, G.T.; Salk, M.S.

    1991-09-01

    This Environmental Regulatory Update Table (August 1991) provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  4. Environmental Regulatory Update Table, September 1991

    Energy Technology Data Exchange (ETDEWEB)

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1991-10-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  5. Environmental Regulatory Update Table, October 1991

    Energy Technology Data Exchange (ETDEWEB)

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1991-11-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  6. Environmental Regulatory Update Table, April 1989

    Energy Technology Data Exchange (ETDEWEB)

    Houlberg, L.; Langston, M.E.; Nikbakht, A.; Salk, M.S.

    1989-05-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  7. Environmental Regulatory Update Table, April 1989

    Energy Technology Data Exchange (ETDEWEB)

    Houlberg, L.; Langston, M.E.; Nikbakht, A.; Salk, M.S.

    1989-05-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  8. Environmental regulatory update table, March 1989

    Energy Technology Data Exchange (ETDEWEB)

    Houlberg, L.; Langston, M.E.; Nikbakht, A.; Salk, M.S.

    1989-04-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  9. Environmental Regulatory Update Table, November 1991

    Energy Technology Data Exchange (ETDEWEB)

    Houlberg, L.M.; Hawkins, G.T.; Salk, M.S.

    1991-12-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  10. Preliminary Determination on Chemical Components of Leaves from Phyllostachys vivax McClure cv. aureocaulis%黄秆乌哺鸡竹叶化学成分的测定

    Institute of Scientific and Technical Information of China (English)

    张衡锋

    2011-01-01

    [目的]测定黄秆乌哺鸡竹叶的化学成分.[方法]以当年生和3年生黄秆乌哺鸡竹成竹为试材,从竹子的顶梢、中部和基部采集样品,对其水提取物.采用硝酸铝-亚硝酸钠比色法测定总黄酮含量,福尔马林还原比色法测定总酚含量,凯氏定氮法和分光光度法测定蛋白质和总糖含量.[结果]黄秆鸟哺鸡竹新叶中总黄酮含量较高,老叶中总酚含量较高,黄酮含量平均为1.65%,总酚含量平均为2.35%;竹叶的蛋白质含量平均为21.37%;竹叶的总糖含量平均为36.99%,多糖含量平均为25.01%.[结论]黄秆乌哺鸡竹叶中的水提取物含量平均为24.64%,水溶性糖含量平均为11.98%,除含糖类外,还含有黄酮、酚类和蒽醌等化合物,因此黄秆乌哺鸡竹叶具有很好的抗癌保健作用.可开发为一种代茶饮料.%[Objective ] The study aimed to determin the chemical components of leaves from Phyllostachys vivax McClure cv. aureocaulis.[ Method] With that year and 3-year old Phyllostachys vivax as the tested material,the samples were collected from the top, middle and basal of the bamboo shoots and were extracted by hot water extraction. The total flavone content and the total phenol content in the water extract of Aureocaulis were determined by using Al ( NO3 ) 3-NaNO2 and Forint-reagent-reversion colorimetry resp. , its the protein content and total sugar content were measured by using Kjeldahl and spectrophotometric methods resp. [ Result ] The total flavone content in new leaves of Phyllostachys vivax was higher and the total phenol content in the old leaves of Phyllostachys vivaxs was higher. Generally, the total flavone content in Phyllostachys vivax leaf averaged by 1.65 % and its total phenol content averaged by 2.35%. The protein content in Phyllostachys vivax leaf averaged by 21.37% and its total sugar content averaged by 36.99%. [ Conclusion]Phyllostachys vivax leaves had mean water extract content of 24.64% and had

  11. Preliminary results on the determination of ultratrace amounts of cadmium in tea samples using a flow injection on-line solid phase extraction separation and preconcentration technique to couple with a sequential injection hydride generation atomic fluorescence spectrometry.

    Science.gov (United States)

    Duan, Taicheng; Song, Xuejie; Jin, Dan; Li, Hongfei; Xu, Jingwei; Chen, Hangting

    2005-10-31

    In this work, a method was developed for determination of ultra-trace levels of Cd in tea samples by atomic fluorescence spectrometry (AFS). A flow injection solid phase extraction (FI-SPE) separation and preconcentration technique, to on-line couple with a sequential injection hydride generation (SI-HG) technique is employed in this study. Cd was preconcentrated on the SPE column, which was made from a neutral extractant named Cyanex 923, while other matrix ions or interfering ions were completely or mostly separated off. Conditions for the SPE separation and preconcentration, as well as conditions for the HG technique, were studied. Due to the separation of interfering elements, Cd hydride generation efficiency could be greatly enhanced with the sole presence of Co(2+) with a concentration of 200mugL(-1), which is much lower than those in other works previously reported. Interferences on both the Cd separation and preconcentration, and Cd hydride generation (HG) were investigated; it showed that both the separation and preconcentration system, and the HG system had a strong anti-interference ability. The SPE column could be repeatedly used at least 400 times, a R.S.D. of 0.97% was obtained for 6 measurements of Cd with 0.2mugL(-1) and a correlation coefficiency of 1.0000 was obtained for the measurement of a series of solutions with Cd concentrations from 0.1 to 2mugL(-1). The method has a low detection limit of 10.8ngL(-1) for a 25mL solution and was successfully validated by using two tea standard reference materials (GBW08513 and GBW07605).

  12. Preliminary Identification of Six Antagonistic Actinomycetes in Soil Determination of Its Fungicidal Activities%6株土壤拮抗放线菌的初步鉴定及其抗菌活性测定

    Institute of Scientific and Technical Information of China (English)

    龙建友; 夏建荣

    2011-01-01

    [目的]初步鉴定6株放线菌种类,并测定其发酵产物的抗菌活性.[方法]采用形态学方法鉴定6株放线菌菌株种类,以抑制菌丝生长速率法、孢子萌发法、盆栽和大田试验系统测定6株放线菌菌株发酵产物的杀菌活性.[结果]形态学初步鉴定结果表明,6株菌株属于链霉菌属.生物测定结果表明,500 μg/ml的6株放线菌发酵产物,对棉花枯萎病菌的菌丝生长抑制率均在90%以上;对番茄灰霉病菌、烟草赤星病菌、南瓜枯萎病菌的菌丝生长抑制率也在80%以上.其中,GZ-204和GZ-331菌株发酵产物对小麦根腐病菌和玉米弯孢叶斑病菌的孢子萌发抑制率分别为97.8%、98.2%和99.5%、94.6%.盆栽试验结果表明,GZ-204和GZ-331菌株发酵产物对小麦白粉病的保护效果分别为78.8%和87.1%,治疗效果为62.4%和68.5%.田间试验结果表明,GZ-204和GZ-331菌株发酵200倍稀释液对小麦白粉病的防治效果分别达50.5%,69.2%.[结论]研究结果为新型土壤放线菌源农药的研制奠定了基础.%[ Objective ] The paper was to preliminarily identify the species of six strains of actinomycetes, and to determine the fungicidul activities of their fermentation products. [ Method] The species of six strains of actinomycetes were identified by morphological method, and the fungicidal activities of the fermentation products of six strains of actinomycetes were systematically determined by series of methods including mycelial growth rate inhibition method, spore germination method, pottirg and field test. [ Result] Morphological identification results showed that six strains belonged to streptomyces. Biological determination results indicated that the inhibition rates of the fermentation products of six strains of actinomycetes with the concentration of 500 μg/ml against the mycelial growth of Fusarium oxysporum f. sp. Vasinfectum were all greater than 90%; the inhibition rates against the mycelial growth of Botrytis

  13. 75 FR 34962 - Pennsylvania Regulatory Program

    Science.gov (United States)

    2010-06-21

    ... another site is more suitable based upon engineering, geology, economics, transportation systems, and... to the actual language of state regulatory programs and program amendments because each program is...

  14. Vertical infraclavicular brachial plexus block in children: a preliminary study.

    NARCIS (Netherlands)

    Jose Maria, B. de; Tielens, L.K.P.

    2004-01-01

    BACKGROUND: Brachial plexus blockade is a well-established technique in upper limb surgery. Among the infraclavicular approaches, the vertical infraclavicular brachial plexus (VIP) block is easy to perform and has a large spectrum of nerve blockade. The aim of this preliminary study was to determine

  15. Texting to increase physical activity in teens: Development & preliminary

    Science.gov (United States)

    Our purpose was to present formative research and preliminary results for a self-determination-theory (SDT)-based text messages to promote physical activity (PA) among teens. Thirty 14- to 17-year olds, stratified by gender and race/ethnicity (Black, Hispanic, White), were recruited to participate i...

  16. Impromptu Speaking and Interpretation Studies: A Preliminary Study

    Science.gov (United States)

    Heinz, Michael

    2013-01-01

    The purpose of this preliminary study was to look at forensics-based competition events and determine what, if any, impact they could have on the language learning and public speaking skills of interpreters in training. This paper details the nature of the impromptu and extemporaneous speaking events in forensics competitions and introduces a…

  17. Impromptu Speaking and Interpretation Studies: A Preliminary Study

    Science.gov (United States)

    Heinz, Michael

    2013-01-01

    The purpose of this preliminary study was to look at forensics-based competition events and determine what, if any, impact they could have on the language learning and public speaking skills of interpreters in training. This paper details the nature of the impromptu and extemporaneous speaking events in forensics competitions and introduces a…

  18. Antibióticos antifúngicos produzidos por actinomicetos do Brasil e sua determinação preliminar nos meios experimentais Antifungal antibiotics produced by Brazilian actinomycetes and its preliminary determination in experimental media

    Directory of Open Access Journals (Sweden)

    Keidi Ujikawa

    2003-06-01

    Full Text Available Várias amostras de solo do Brasil foram semeadas em placas de ágar e diversas cepas de actinomicetos produtoras de antibióticos antifúngicos foram isoladas. Foram desenvolvidos meios para eliciação da biossíntese dos antibióticos e métodos para determinação rápida do seu rendimento. Ao todo, foram isoladas 41 cepas de actinomicetos aeróbios produtoras de metabólitos antifúngicos. Destes, 11 (26,8% eram macrolídeos tetraênicos, 13 (31,7% macrolídeos pentaênicos, 1 (2,4%, macrolídeo oxopentaênico, 1 (2,4% macrolídeo hexaênico e 6 (14,6% macrolídeos heptaênicos. Os antibióticos antifúngicos produzidos pelas restantes 9 cepas ativas (21,9% não eram poliênicos. Os poliênicos mais utilizados atualmente na clínica são do tipo tetraênico (nistatina e heptaênico (anfotericina B. Um meio à base de leite de soja favoreceu extraordinariamente a eliciação da biossíntese de polienos por algumas cepas, enquanto que para outras não houve favorecimento e para outras foi prejudicial. Os rendimentos obtidos atingiram cerca de 6000 U de antibióticos poliênicos por mL.Various Brazilian soil samples were seeded in agar plates and several strains of antifungal antibiotic producing actinomycetes were isolated. Antibiotic biosynthesis elicitation media were developed and methods for determination of yields were studied. A total of 41 antifungal antibiotic producing strains of aerobic actinomycetes resulted. Among the antibiotics produced, 11 (26.8% were grouped as macrolide tetraenes, 13 (31.7% as pentaenes, 1 (2.4% as oxo pentaene, 1 (2.4% as hexaene and 6 (14.6% as heptaenes. Several of these strains also produced antibacterial antibiotics, like polyether antibiotics. The remaining 9 active strains (21.9% produced non polyene type of antifungals. A medium based on soybean milk favored extraordinarily the elicitation of polyenes biosynthesis by some native strains, while with other strains, this was not favored, while with

  19. Determinación de volúmenes pulmonares mediante pletismografía en pacientes con fíbrosis quística Lung volume determinations by whole plethysmography in cystic fibrosis patients: A preliminary report

    Directory of Open Access Journals (Sweden)

    ILSE CONTRERAS E

    2008-03-01

    Full Text Available Introducción: La fibrosis quística (FQ exhibe un deterioro progresivo de la función pulmonar (FP asociada a infecciones recurrentes. Objetivo: Evaluar la FP en sujetos con FQ mediante espirometría, saturometría y pletismografía (PG determinando alguna relación matemática. Pacientes y Métodos: Se identificaron 10 pacientes capaces de realizar CVF, CRF, VR, CPT, VEF1, y FEF25-75 %; comparándose con los valores de Zapletal y de 33 controles sanos. Resultados: Edad promedio 13,6 años (rango: 9-20. Sa0(2y VEF1fueron normales en 10 y 5 sujetos, respectivamente (4 tenían VEF1entre 65-80%. La PG mostró 4 pacientes con VR/CPT > 30%, 3 con aumento de CRF y VR/CPT, sólo uno tuvo PG normal. Los promedios de CPT y VR fueron superiores a valores de referencia y controles (p Introduction: Cystic fibrosis (CF patients develop a progressive impairment of pulmonary function tests (PFT by recurrent infection. Objective: To evaluate PFT in CF patients using spirometry, oxygen saturometry (Sa0(2 and whole plethysmography (WP for determining possible mathematical relationships. Methods: FVC, FRC, RV, TLC, FEV1, FEF25.75, obtained in 10 CF patients were compared with Zapletal's reference values and with the values obtained in 33 healthy-school children. Results: Mean age 13.6 years-old (range: 9-20. All CF patients had normal Sa0(2, FEV1 was normal in five (four had FEV1 between 65-80%, 4 had RV/TLC > 30%, 3 had increased FRC and RV/TLC, only one CF patient had WP normal. The average of TLC and RV were higher than reference values and control group (p < 0.05. We found an inverse relationship between FEV1, FEF25-75 and RV/TLC [r = -0.642 (p < 0.05 and r = -0.803 (p < 0.01; respectively]. Conclusion: This study suggests an increase of pulmonary volume in CF patients with not necessarily abnormal spirometry and an inverse mathematical relationship between FEV1, FEF25-75 and RV/TLC

  20. 5株生姜促生菌的初步鉴定及产 IAA 和抑菌能力测定%Preliminary Identification, IAA-Producing and Antibacterial Capacity Determination of Five Ginger Growth-Promoting Bacteria

    Institute of Scientific and Technical Information of China (English)

    王西祥; 徐坤; 张冬梅; 杜秉海; 杨倩倩; 胡秀娜; 丁延芹

    2015-01-01

    为明确5株生姜促生菌的分类地位和促生活性,本试验通过观察其菌体及菌落形态特征、生理生化特性和16S rDNA序列分析,初步确定GJ3为解淀粉芽孢杆菌,GJ130为纳什维尔链霉菌,NS87为非脱羧勒克氏菌,NS178为枯草芽孢杆菌,NS111为路德维希肠杆菌。用抑菌谱法测定了5株促生菌的拮抗特性,其中GJ3和NS178具有较广的抑菌谱,对14种病原真菌均具有拮抗效果。 Salkowski比色法定量测定了5株促生菌产吲哚乙酸能力,菌株NS111产吲哚乙酸能力最强,其发酵液IAA含量为148.80 mg/L。%In this research, the thallus and colony morphology characters, physiology and biochemistry properties and 16S rDNA sequence of five ginger growth-promoting bacteria were observed and analyzed.The strain GJ3, GJ130, NS87, NS178 and NS111 were identified as Bacillus amyloliquefaciens, Streptomyces nash-villensis, Leclercia adecarboxylata, Bacillus subtilis and Enterobacter ludwigii respectively.In addition, the an-tibacterial capacities of five strains were determined by antibacterial spectrum method.Among which, the strain GJ3 and NS178 had extensive antimicrobial spectrum, which both showed antagonism effects on 14 kinds of pathogenic fungi.The indole acetic acid ( IAA) -producing abilities of five strains were also meas-ured using Slkowski colorimetry.The strain NS111 had the best IAA-producing ability, whose IAA content of the fermentation liquid reached 148.80 mg/L.

  1. Regulatory T cells as immunotherapy

    Directory of Open Access Journals (Sweden)

    Benjamin David Singer

    2014-02-01

    Full Text Available Regulatory T cells (Tregs suppress exuberant immune system activation and promote immunologic tolerance. Because Tregs modulate both innate and adaptive immunity, the biomedical community has developed intense interest in using Tregs for immunotherapy. Conditions that require clinical tolerance to improve outcomes—autoimmune disease, solid organ transplantation, and hematopoietic stem cell transplantation—may benefit from Treg immunotherapy. Investigators have designed ex vivo strategies to isolate, preserve, expand, and infuse Tregs. Protocols to manipulate Treg populations in vivo have also been considered. Barriers to clinically feasible Treg immunotherapy include Treg stability, off-cell effects, and demonstration of cell preparation purity and potency. Clinical trials involving Treg adoptive transfer to treat graft versus host disease preliminarily demonstrated the safety and efficacy of Treg immunotherapy in humans. Future work will need to confirm the safety of Treg immunotherapy and establish the efficacy of specific Treg subsets for the treatment of immune-mediated disease.

  2. Establishment and preliminary application of an ELISA method for determination of pertactin%检测百日咳黏着素的酶联免疫吸附法的建立及初步应用

    Institute of Scientific and Technical Information of China (English)

    王玲; 潘殊男; 张霖阳; 夏菊; 王宇星; 张萍; 肖詹蓉

    2014-01-01

    目的 建立定量检测白喉-破伤风-无细胞百日咳疫苗生产过程中黏着素(pertactin,Prn)的方法.方法 纯化的Prn免疫家兔以制备高效价血清抗Prn抗体.辛酸-硫酸铵沉淀法纯化抗Prn多克隆抗体并进行辣根过氧化物酶标记,建立双抗体夹心ELISA法.结果 建立的方法与丝状血凝素和百日咳毒素无交叉反应,特异性较好.该ELISA法在1.25 ~ 80.00μg/L Prn测量区间有最佳线性,相关系数>0.99.实验内和实验间检测64.0、32.0、16.0 μg/L Prn,变异系数为2.6%~7.7%,回收率为84.9%~ 95.5%,精密度和准确度均符合常规质控要求,因此该法的定量限度为16.0 μg/L.结论 建立的ELISA法可有效检测百日咳疫苗纯化过程中的Prn含量,为组分百日咳疫苗质量控制奠定了重要基础.%Objective To establish an ELISA method for quantitative determination of pertactin (Prn) during production of combined diphtheria,tetanus and acellular pertussis vaccine.Methods Rabbits were immuned with purified Prn to prepare high-titer serum antibodies against Prn.The polyclonal antibodies against Prn were purified by octanoic acid-ammonium sulfate precipitation method and labeled with horseradish peroxidase to establish a double antibody sandwich ELISA method.Results The ELISA method had good specificity for Prn and no cross reaction with filamentous hemagglutinin and pertussis toxin.The best linearity of the ELISA method was formed in the range of 1.25-80.00 μg/L (r > 0.99).The coefficient of variation and recover rates of intra-and inter-assay were 2.6%-7.7% and 84.9%-95.5% respectively when 64.0,32.0 and 16.0 μg/L standard Prn were detected,and the precision and accuracy both met requirements of quality control.The quantitative limit was 16.0 μg/L.Conclusion The established ELISA method can be applied to detecting Prn during purification of pertussis vaccine and lay the foundation for quality control of Prn.

  3. Establishment and preliminary application of an ELISA method for determination of tetanus toxoid%检测破伤风类毒素的酶联免疫吸附法的建立及应用

    Institute of Scientific and Technical Information of China (English)

    王玲; 王珣; 韩俊杰; 张建玲; 杨云凯; 张娜; 佟芳; 潘殊男; 张霖阳

    2016-01-01

    Objective To establish an ELISA method for quantitative determination of tetanus toxoid (TT ) for DTaP .Methods Rabbits were immunized with purified TT to prepare high‐titer serum antibodies against TT .Polyclonal anti‐TT antibodies were purified by octanoic acid‐ammonium sulfate precipitation method and labeled with horseradish peroxidase to establish a double antibody sandwich ELISA method .Results The ELISA method had good specificity for TT and no cross reactivities with filamentous hemagglutinin ,pertussis toxin or diphtheria toxoid .The best linearity of the ELISA method was within the range of 0 .5‐16 .0 Lf /L TT (R 2 > 0 .99) .The coefficient of variation and recover rates of intra‐ and inter‐assay were 4 .7% ‐9 .8% and 92 .7% ‐109 .0% ,respectively ,when 14 .0 ,12 .0 ,6 .0 ,3 .0 and 1 .5 Lf /L TT standards were detected ,and the precision and accuracy both met requirements of quality control . The detection limit of the ELISA method was 1 .5 Lf /L TT . Conclusion The established ELISA method can be applied to detecting TT during purification of tetanus vaccine and lays foundation for quality control of TT .%目的:建立定量检测白喉‐破伤风‐无细胞百日咳疫苗生产过程中破伤风类毒素(tetanus toxoid ,TT )的方法。方法 TT 免疫家兔以制备高效价血清抗 TT 抗体。辛酸‐硫酸铵沉淀法纯化抗TT 多克隆抗体并进行辣根过氧化物酶标记,建立双抗体夹心 ELISA 法。结果建立的 ELISA 法与丝状血凝素、百日咳毒素及白喉类毒素无交叉反应,特异性较好。该 ELISA 法在0.5~16.0 Lf /L TT 检测区间有最佳线性,决定系数>0.99。实验内和实验间检测14.0、12.0、6.0、3.0和1.5 Lf/L TT ,变异系数为4.7%~9.8%,回收率为92.7%~109.0%,精密度和准确度均符合常规质控要求。该法的定量下限为1.5 Lf/L TT 。结论建立的 ELISA 法可有效检测破

  4. Reduction of regulatory risk: a network economic approach

    OpenAIRE

    Knieps, Günter; Weiß, Hans-Jörg

    2007-01-01

    Several definitions of regulatory risk are known from the literature. From the perspective of regulatory reform it is important to differentiate between the impact of a given regulatory scheme on the firm's risk exposure and the risk arising from discretionary behavior of regulatory agencies. Whereas the conse-quences of effective regulation in principle are known and accepted, excessive regulatory discretion may cause a strong need for regulatory reform. Regulatory reform focussing on the re...

  5. Preliminary analysis of alternative fuel cycles for proliferation evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Steindler, M. J.; Ripfel, H. C.F.; Rainey, R. H.

    1977-01-01

    The ERDA Division of Nuclear Research and Applications proposed 67 nuclear fuel cycles for assessment as to their nonproliferation potential. The object of the assessment was to determine which fuel cycles pose inherently low risk for nuclear weapon proliferation while retaining the major benefits of nuclear energy. This report is a preliminary analysis of these fuel cycles to develop the fuel-recycle data that will complement reactor data, environmental data, and political considerations, which must be included in the overall evaluation. This report presents the preliminary evaluations from ANL, HEDL, ORNL, and SRL and is the basis for a continuing in-depth study. (DLC)

  6. Development and preliminary validation of the Opioid Abuse Risk Screener.

    Science.gov (United States)

    Henrie-Barrus, Patricia; Averill, Lynnette A; Sudweeks, Richard R; Averill, Christopher L; Mota, Natalie

    2016-01-01

    Prescription opioid drug abuse has reached epidemic proportions. Individuals with chronic pain represent a large population at considerable risk of abusing opioids. The Opioid Abuse Risk Screener was developed as a comprehensive self-administered measure of potential risk that includes a wide range of critical elements noted in the literature to be relevant to opioid risk. The creation, refinement, and preliminary modeling of the item pool, establishment of preliminary concurrent validity, and the determination of the factor structure are presented. The initial development and validation of the Opioid Abuse Risk Screener shows promise for effective risk stratification.

  7. Development and preliminary validation of the Opioid Abuse Risk Screener

    Directory of Open Access Journals (Sweden)

    Patricia Henrie-Barrus

    2016-05-01

    Full Text Available Prescription opioid drug abuse has reached epidemic proportions. Individuals with chronic pain represent a large population at considerable risk of abusing opioids. The Opioid Abuse Risk Screener was developed as a comprehensive self-administered measure of potential risk that includes a wide range of critical elements noted in the literature to be relevant to opioid risk. The creation, refinement, and preliminary modeling of the item pool, establishment of preliminary concurrent validity, and the determination of the factor structure are presented. The initial development and validation of the Opioid Abuse Risk Screener shows promise for effective risk stratification.

  8. Preliminary Phytochemical Studies.

    Science.gov (United States)

    2016-01-01

    Plants are the natural producers of medicinal agents like alkaloids, flavonoids, tannins, and phenolics. These phytocompounds alone or in combination act as a therapeutic agent in various disease complications. Various chemical reagents are used to determine the major phytochemicals present in plant parts. Protocols involved in screening of alkaloids, carbohydrates, glycosides, saponins, phytosterols, fixed oils, and fats are shown in this chapter.

  9. Regulatory fit messages and physical activity motivation.

    Science.gov (United States)

    Pfeffer, Ines

    2013-04-01

    Targeted communication about health behaviors seems to be more effective than mass communication in which undifferentiated audiences receive identical messages. Regulatory focus is psychological variable that can be used to build two target groups: promotion-focused or prevention-focused people. It is hypothesized that targeting messages to an individual's regulatory focus creates regulatory fit and is more successful to promote a physically active lifestyle than nonfit messages. Two different print messages promoting a physically active lifestyle derived from regulatory focus theory (promotion message vs. prevention message) were randomly assigned to N = 98 participants after measuring their regulatory focus. It was examined whether regulatory fit between the regulatory focus and the assigned print message would lead to more positive evaluations in the dependent variables inclination toward the message (preference for the message), intention to perform the behavior, prospective and retrospective feelings associated with the behavior (positive and negative), and perceived value of the behavior directly after reading the message. Hierarchical linear regression analyses revealed that regulatory fit led to stronger intentions in the prevention-message condition and more prospective positive and retrospective positive feelings associated with the behavior in the promotion-message condition in contrast to the nonfit conditions. Prospective positive feelings associated with the behavior mediated the effect of regulatory fit on intention. The results partly provided support for the regulatory fit concept. Matching print messages to the regulatory focus of individuals seems to be a useful approach to enhance physical activity motivation. Future studies should include an objective measure of physical activity behavior.

  10. 75 FR 17460 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing...

    Science.gov (United States)

    2010-04-06

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing and...'') \\1\\ and Rule 19b-4 thereunder,\\2\\ notice is hereby given that on March 26, 2010, Financial Industry Regulatory Authority, Inc. (``FINRA'') filed with the Securities and Exchange Commission (``SEC''...

  11. 78 FR 59995 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

    Science.gov (United States)

    2013-09-30

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of... Rule 19b-4 thereunder,\\2\\ notice is hereby given that on September 16, 2013, the Financial Industry Regulatory Authority, Inc. (``FINRA'') filed with the Securities and Exchange Commission (``Commission'')...

  12. 75 FR 30457 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

    Science.gov (United States)

    2010-06-01

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of Proposed Rule Change Relating to the Restated Certificate of Incorporation of Financial Industry Regulatory...'') \\1\\ and Rule 19b-4 thereunder,\\2\\ notice is hereby given that on May 21, 2010, Financial...

  13. 77 FR 5610 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing...

    Science.gov (United States)

    2012-02-03

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing and...\\ and Rule 19b-4 thereunder,\\2\\ notice is hereby given that on January 24, 2012, Financial Industry Regulatory Authority, Inc. (``FINRA'') filed with the Securities and Exchange Commission (``Commission'')...

  14. 78 FR 46652 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

    Science.gov (United States)

    2013-08-01

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of... thereunder,\\3\\ notice is hereby given that, on July 18, 2013, Financial Industry Regulatory Authority, Inc... as described in Items I, II and III below, which Items have been prepared by the...

  15. 75 FR 27606 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing...

    Science.gov (United States)

    2010-05-17

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing and... (``Act'') \\1\\ and Rule 19b-4 thereunder,\\2\\ notice is hereby given that on April 27, 2010, the Financial Industry Regulatory Authority, Inc. (``FINRA'') (f/k/a National Association of Securities Dealers,...

  16. 78 FR 37261 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

    Science.gov (United States)

    2013-06-20

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of... Rule 19b-4 thereunder,\\2\\ notice is hereby given that on June 3, 2013, Financial Industry Regulatory... rule change from interested persons. \\1\\ 15 U.S.C. 78s(b)(1). \\2\\ 17 CFR 240.19b-4. I....

  17. 77 FR 68181 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing...

    Science.gov (United States)

    2012-11-15

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing and... Rule 19b-4 thereunder,\\2\\ notice is hereby given that on November 2, 2012, Financial Industry Regulatory Authority, Inc. (``FINRA'') filed with the Securities and Exchange Commission (``SEC''...

  18. 75 FR 8771 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving...

    Science.gov (United States)

    2010-02-25

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving Proposed Rule Change To Adopt FINRA Rule 2261 (Disclosure of Financial Condition) in the Consolidated FINRA Rulebook February 18, 2010. On November 18, 2009, the Financial Industry Regulatory Authority,...

  19. 76 FR 65307 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

    Science.gov (United States)

    2011-10-20

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...''),\\1\\ and Rule 19b-4 thereunder,\\2\\ notice is hereby given that on October 6, 2011, the Financial Industry Regulatory Authority, Inc. (``FINRA'') filed with the Securities and Exchange Commission...

  20. 76 FR 11830 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing...

    Science.gov (United States)

    2011-03-03

    ... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing and... Rule 19b-4 thereunder,\\2\\ notice is hereby given that on February ] 22, 2011, Financial Industry Regulatory Authority, Inc. (``FINRA'') filed with the Securities and Exchange Commission (``SEC''...