Serum Ionized Calcium Quantification for Staging Canine Periodontal Disease: A Preliminary Study.

Science.gov (United States)

Miguel Carreira, L; Daniela, Dias; Pedro, Azevedo

2015-06-01

Periodontal diseases (PD) are infectious, inflammatory, progressive diseases of the oral cavity affecting people and dogs. PD takes 2 forms: gingivitis and periodontitis. Diagnosing or staging PD can be achieved only with dental x-rays and periodontal probing, both of which require the use of general anesthesia in dogs. This study aimed to determine whether serum ionized calcium ([iCa(2+)]) levels can be useful in preliminary PD staging in dogs. A sample of 40 dogs (n = 40) was divided into 4 groups (n = 10 each) based on the following PD stages: G1 (gingivitis), G2 (initial periodontitis), G3 (moderate periodontitis), and G4 (severe periodontitis). The groups were then subjected to [iCa(2+)] quantification. Statistically significant differences were observed between PD stages and [iCa(2+)] for all stages except G3 and G4. Therefore, this parameter can be used as an additional tool to establish and monitor preliminary PD status. Copyright © 2015 Elsevier Inc. All rights reserved.

California's forest resources. Preliminary assessment

Energy Technology Data Exchange (ETDEWEB)

1979-01-01

This Preliminary Assessment was prepared in response to the California Forest Resources Assessment and Policy Act of 1977 (FRAPA). This Act was passed to improve the information base upon which State resource administrators formulate forest policy. The Act provides for this report and a full assessment by 1987 and at five year intervals thereafter. Information is presented under the following chapter titles: introduction to the forest resources assessment program; the forest area: a general description; classifications of the forest lands; the watersheds; forest lands and the air resource; fish and wildlife resources; the forested rangelands; the wilderness; forest lands as a recreation resource; the timber resource; wood energy; forest lands and the mineral, fossil fuels, and geothermal energy resources; mathematically modeling California's forest lands; vegetation mapping using remote sensing technology; important forest resources legislation; and, State and cooperative State/Federal forestry programs. Twelve indexes, a bibliography, and glossary are included. (JGB)

Bats roosting in public buildings: A preliminary assessment from ...

African Journals Online (AJOL)

Madagascar has many synanthropic bat species but relatively little is known about how people interact with them. A preliminary assessment on the presence of bats in buildings and their interactions with people was conducted in the eastern town of Moramanga. Fifty of the 156 buildings were reported to contain active bat ...

A Preliminary Assessment of Groundwater Samples around a Filling ...

African Journals Online (AJOL)

This paper is a preliminary assessment of groundwater samples around a filling station in Diobu area of Port Harcourt for four years at intervals of two years with a view to determine the level of groundwater pollution. It examines the physiochemical, major ions and heavy metal aspect of groundwater quality around the study ...

Preliminary Safeguards Assessment for the Pebble-Bed Fluoride High-Temperature Reactor (PB-FHR) Concept

Energy Technology Data Exchange (ETDEWEB)

Disser, Jay; Arthur, Edward; Lambert, Janine

2016-09-01

This report examines a preliminary design for a pebble bed fluoride salt-cooled high temperature reactor (PB-FHR) concept, assessing it from an international safeguards perspective. Safeguards features are defined, in a preliminary fashion, and suggestions are made for addressing further nuclear materials accountancy needs.

40 CFR 300.305 - Phase II-Preliminary assessment and initiation of action.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 27 2010-07-01 2010-07-01 false Phase II-Preliminary assessment and initiation of action. 300.305 Section 300.305 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... the OSC is informed of their activities in natural resource damage assessment that may affect response...

Preliminary assessment report for National Guard Training Center, Georgia Army National Guard, Fort Stewart, Georgia

International Nuclear Information System (INIS)

1993-07-01

This report presents the results of the preliminary assessment (PA) conducted by Argonne National Laboratory at the Georgia Army National Guard (GAARNG) facility near Hinesville, Georgia, known as the National Guard Training Center (NGTC). Preliminary assessments of federal facilities are being conducted to compile the information necessary for completing preremedial activities and to provide a priority basis for completing corrective actions (where necessary) in response to releases of hazardous substances. The principal objective of the PA is to characterize the site accurately and determine the need for further action by examining previous site activities, types and quantities of hazardous substances utilized, and potential pathways by which contamination could affect public health and the environment. The scope of this assessment is limited to the facilities and past activities contained within the NGTC. Preliminary assessment site score sheet information is also provided for the NGTC. However, this assessment report is intended to be read in conjunction with a previous IRP assessment of Fort Stewart completed in 1992 (USATHAMA 1992) and to provide comprehensive information on the NGTC area for incorporation with information contained in that previous assessment for the entirety of Fort Stewart

Preliminary report of the Hepatic Encephalopathy Assessment Driving Simulator (HEADS) score.

Science.gov (United States)

Baskin-Bey, Edwina S; Stewart, Charmaine A; Mitchell, Mary M; Bida, John P; Rosenthal, Theodore J; Nyberg, Scott L

2008-01-01

Audiovisual simulations of real-life driving (ie, driving simulators) have been used to assess neurologic dysfunction in a variety of medical applications. However, the use of simulated driving to assess neurologic impairment in the setting of liver disease (ie, hepatic encephalopathy) is limited. The aim of this analysis was to develop a scoring system based on simulated driving performance to assess mild cognitive impairment in cirrhotic patients with hepatic encephalopathy. This preliminary analysis was conducted as part of the Hepatic Encephalopathy Assessment Driving Simulator (HEADS) pilot study. Cirrhotic volunteers initially underwent a battery of neuropsychological tests to identify those cirrhotic patients with mild cognitive impairment. Performance during an audiovisually simulated course of on-road driving was then compared between mildly impaired cirrhotic patients and healthy volunteers. A scoring system was developed to quantify the likelihood of cognitive impairment on the basis of data from the simulated on-road driving. Mildly impaired cirrhotic patients performed below the level of healthy volunteers on the driving simulator. Univariate logistic regression and correlation models indicated that several driving simulator variables were significant predictors of cognitive impairment. Five variables (run time, total map performance, number of collisions, visual divided attention response, and average lane position) were incorporated into a quantitative model, the HEADS scoring system. The HEADS score (0-9 points) showed a strong correlation with cognitive impairment as measured by area under the receiver-operator curve (.89). The HEADS system appears to be a promising new tool for the assessment of mild hepatic encephalopathy.

EXPLOSION POTENTIAL ASSESSMENT OF HEAT EXCHANGER NETWORK AT THE PRELIMINARY DESIGN STAGE

Directory of Open Access Journals (Sweden)

MOHSIN PASHA

2016-07-01

Full Text Available The failure of Shell and Tube Heat Exchangers (STHE is being extensively observed in the chemical process industries. This failure can cause enormous production loss and have a potential of dangerous consequences such as an explosion, fire and toxic release scenarios. There is an urgent need for assessing the explosion potential of shell and tube heat exchanger at the preliminary design stage. In current work, inherent safety index based approach is used to resolve the highlighted issue. Inherent Safety Index for Shell and Tube Heat Exchanger (ISISTHE is a newly developed index for assessing the inherent safety level of a STHE at the preliminary design stage. This index is composed of preliminary design variables and integrated with the process design simulator (Aspen HYSYS. Process information can easily be transferred from process design simulator to MS Excel spreadsheet owing to this integration. This index could potentially facilitate the design engineer to analyse the worst heat exchanger in the heat exchanger network. Typical heat exchanger network of the steam reforming process is presented as a case study and the worst heat exchanger of this network has been identified. It is inferred from this analysis that shell and tube heat exchangers possess high operating pressure, corrected mean temperature difference (CMTD and flammability and reactive potential needs to be critically analysed at the preliminary design stage.

Preliminary market assessment of fluidized-bed waste-heat recovery technology

Energy Technology Data Exchange (ETDEWEB)

Campos, F.T.; Fey, C.L.; Grogan, P.J.; Klein, N.P.

1980-06-01

A preliminary assessment of fluidized-bed waste-heat recovery (FBWHR) system market potential is presented with emphasis on the factors influencing industrial acceptability. Preliminary market potential areas are identified based on the availability of waste heat. Trends in energy use are examined to see the effect they might have on these market potential areas in the future. Focus groups interviews are used to explore important factors in the industrial decision-making process. These important factors are explored quantitatively in a survey of industrial plant engineers. The survey deals with the waste-heat boiler configuration of the FBWHR system. Results indicate market acceptance of the fluidized-bed waste-heat boiler could be quite low.

Egypt--United States cooperative energy assessment: report on preliminary discussions

Energy Technology Data Exchange (ETDEWEB)

1978-04-01

Egyptian and U.S. Government representatives met in Cairo during the period of February 14-22, 1978 to discuss a cooperative Egypt-U.S. assessment of the energy demand and supply options available to Egypt. This report summarizes those preliminary discussions. The discussions accomplished the following: the background and objectives of the U.S. initiative for a cooperative energy assessment with Egypt were explained; Egyptian electric energy activities and their priorities were presented; methods under consideration for the systematic identification and assessment of energy options available to Egypt were explained; the cooperation of Egyptian energy resource and planning organizations was assured; and arrangements to carry out the cooperative assessment were planned.

Utility of Social Modeling for Proliferation Assessment - Preliminary Findings

International Nuclear Information System (INIS)

Coles, Garill A.; Gastelum, Zoe N.; Brothers, Alan J.; Thompson, Sandra E.

2009-01-01

Often the methodologies for assessing proliferation risk are focused around the inherent vulnerability of nuclear energy systems and associated safeguards. For example an accepted approach involves ways to measure the intrinsic and extrinsic barriers to potential proliferation. This paper describes preliminary investigation into non-traditional use of social and cultural information to improve proliferation assessment and advance the approach to assessing nuclear material diversion. Proliferation resistance assessment, safeguard assessments and related studies typically create technical information about the vulnerability of a nuclear energy system to diversion of nuclear material. The purpose of this research project is to find ways to integrate social information with technical information by explicitly considering the role of culture, groups and/or individuals to factors that impact the possibility of proliferation. When final, this work is expected to describe and demonstrate the utility of social science modeling in proliferation and proliferation risk assessments.

Economic valuation of acidic deposition damages: Preliminary results from the 1985 NAPAP [National Acid Precipitation Assessment Program] damage assessment

International Nuclear Information System (INIS)

Callaway, J.M.; Darwin, R.F.; Nesse, R.J.

1985-01-01

This paper identifies methods used to evaluate the economic damages of acid deposition in the 1985 Damage Assessment being coordinated by the National Acid Precipitation Program. It also presents the preliminary estimates of economic damages for the Assessment. Economic damages are estimated for four effect areas: commercial agriculture and forests, recreational fishing and selected types of materials. In all but the last area, methods are used which incorporate the behavioral responses of individuals and firms or simulated physical damages to resources at risk. The preliminary nature of the estimated damages in each area is emphasized. Over all, the damage estimates should be interpreted with caution. 44 refs., 6 figs., 5 tabs

Preliminary feasibility assessment for Earth-to-space electromagnetic (Railgun) launchers

Science.gov (United States)

Rice, E. E.; Miller, L. A.; Earhart, R. W.

1982-01-01

An Earth to space electromagnetic (railgun) launcher (ESRL) for launching material into space was studied. Potential ESRL applications were identified and initially assessed to formulate preliminary system requirements. The potential applications included nuclear waste disposal in space, Earth orbital applications, deep space probe launchers, atmospheric research, and boost of chemical rockets. The ESRL system concept consisted of two separate railgun launcher tubes (one at 20 deg from the horizontal for Earth orbital missions, the other vertical for solar system escape disposal missions) powered by a common power plant. Each 2040 m launcher tube is surrounded by 10,200 homopolar generator/inductor units to transmit the power to the walls. Projectile masses are 6500 kg for Earth orbital missions and 2055 kg for nuclear waste disposal missions. For the Earth orbital missions, the projectile requires a propulsion system, leaving an estimated payload mass of 650 kg. For the nuclear waste disposal in space mission, the high level waste mass was estimated at 250 kg. This preliminary assessment included technical, environmental, and economic analyses.

Preliminary risk assessment of Power Plant Plomin site contaminated by radioactive slag and ash

International Nuclear Information System (INIS)

Skanata, D.; Sinka, D.; Lokner, V.; Schaller, A.

1996-01-01

There is a certain number of radioactively contaminated sites in the Republic of Croatia, one of them being known as Power Plant Plomin site, which contains radioactive slag and ash. Due to a relatively high quantity of the deposited material, as well as relatively high population density of the neighbouring area, it is very important to assess the impact of the site on human health and environment. Using RESRAD computer code and PATHRAE method a preliminary assessment of doses and radiation risks for the workers who spend most of their working day at the pile has been performed. PATHRAE method has also been used for the assessment of radiation risks for the neighbouring population. The assessment is preliminary in its character due to the lack of input data. On the basis of assessment results, recommendations are being given comprising measurements to be taken with a view to coming up with the final risk assessment, as well as protective measures which should be undertaken in the meantime. (author)

The Anaclitic-Introjective Depression Assessment: Development and preliminary validity of an observer-rated measure.

Science.gov (United States)

Rost, Felicitas; Luyten, Patrick; Fonagy, Peter

2018-03-01

The two-configurations model developed by Blatt and colleagues offers a comprehensive conceptual and empirical framework for understanding depression. This model suggests that depressed patients struggle, at different developmental levels, with issues related to dependency (anaclitic issues) or self-definition (introjective issues), or a combination of both. This paper reports three studies on the development and preliminary validation of the Anaclitic-Introjective Depression Assessment, an observer-rated assessment tool of impairments in relatedness and self-definition in clinical depression based on the item pool of the Shedler-Westen Assessment Procedure. Study 1 describes the development of the measure using expert consensus rating and Q-methodology. Studies 2 and 3 report the assessment of its psychometric properties, preliminary reliability, and validity in a sample of 128 patients diagnosed with treatment-resistant depression. Four naturally occurring clusters of depressed patients were identified using Q-factor analysis, which, overall, showed meaningful and theoretically expected relationships with anaclitic/introjective prototypes as formulated by experts, as well as with clinical, social, occupational, global, and relational functioning. Taken together, findings reported in this paper provide preliminary evidence for the reliability and validity of the Anaclitic-Introjective Depression Assessment, an observer-rated measure that allows the detection of important nuanced differentiations between and within anaclitic and introjective depression. Copyright © 2017 John Wiley & Sons, Ltd.

Interactive Block Games for Assessing Children's Cognitive Skills: Design and Preliminary Evaluation

Directory of Open Access Journals (Sweden)

Kiju Lee

2018-05-01

Full Text Available Background: This paper presents design and results from preliminary evaluation of Tangible Geometric Games (TAG-Games for cognitive assessment in young children. The TAG-Games technology employs a set of sensor-integrated cube blocks, called SIG-Blocks, and graphical user interfaces for test administration and real-time performance monitoring. TAG-Games were administered to children from 4 to 8 years of age for evaluating preliminary efficacy of this new technology-based approach.Methods: Five different sets of SIG-Blocks comprised of geometric shapes, segmented human faces, segmented animal faces, emoticons, and colors, were used for three types of TAG-Games, including Assembly, Shape Matching, and Sequence Memory. Computational task difficulty measures were defined for each game and used to generate items with varying difficulty. For preliminary evaluation, TAG-Games were tested on 40 children. To explore the clinical utility of the information assessed by TAG-Games, three subtests of the age-appropriate Wechsler tests (i.e., Block Design, Matrix Reasoning, and Picture Concept were also administered.Results: Internal consistency of TAG-Games was evaluated by the split-half reliability test. Weak to moderate correlations between Assembly and Block Design, Shape Matching and Matrix Reasoning, and Sequence Memory and Picture Concept were found. The computational measure of task complexity for each TAG-Game showed a significant correlation with participants' performance. In addition, age-correlations on TAG-Game scores were found, implying its potential use for assessing children's cognitive skills autonomously.

Preliminary Mineral Resource Assessment of Selected Mineral Deposit Types in Afghanistan

Science.gov (United States)

Ludington, Steve; Orris, Greta J.; Bolm, Karen S.; Peters, Stephen G.; ,

2007-01-01

INTRODUCTION Wise decision-making and management of natural resources depend upon credible and reliable scientific information about the occurrence, distribution, quantity and quality of a country's resource base. Economic development decisions by governments require such information to be part of a Mineral Resource Assessment. Such Mineral Assessments are also useful to private citizens and international investors, consultants, and companies prior to entry and investment in a country. Assessments can also be used to help evaluate the economic risks and impact on the natural environment associated with development of resources. In February 2002, at the request of the Department of State and the then U.S. Ambassador to Afghanistan (Robert P. Finn), the U.S. Geological Survey (USGS) prepared a detailed proposal addressing natural resources issues critical to the reconstruction of Afghanistan. The proposal was refined and updated in December 2003 and was presented as a 5-year work plan to USAID-Kabul in February 2004. USAID-Kabul currently funds this plan and this report presents a part of the preliminary results obligated for fiscal year 2006. A final Preliminary Assessment of the Non Fuel Mineral Resource of Afghanistan will be completed and delivered at the end of fiscal year 2007. Afghanistan has abundant metallic and non-metallic resources, but the potential resources have never been systematically assessed using modern methods. Much of the existing mineral information for Afghanistan was gathered during the 1950s and continued in the late 1980s until the departure of the geologic advisors from the Soviet Union. During this period, there were many mineral-related activities centered on systematic geologic mapping of the country, collection of geochemical and rock samples, implementation of airborne geophysical surveys, and exploration focused on the discovery of large mineral deposits. Many reports, maps, charts, and tables were produced at that time. Some of

AVLIS Production Plant Preliminary Quality Assurance Plan and Assessment

International Nuclear Information System (INIS)

1984-01-01

This preliminary Quality Assurance Plan and Assessment establishes the Quality Assurance requirements for the AVLIS Production Plant Project. The Quality Assurance Plan defines the management approach, organization, interfaces, and controls that will be used in order to provide adequate confidence that the AVLIS Production Plant design, procurement, construction, fabrication, installation, start-up, and operation are accomplished within established goals and objectives. The Quality Assurance Program defined in this document includes a system for assessing those elements of the project whose failure would have a significant impact on safety, environment, schedule, cost, or overall plant objectives. As elements of the project are assessed, classifications are provided to establish and assure that special actions are defined which will eliminate or reduce the probability of occurrence or control the consequences of failure. 8 figures, 18 tables

Association of Tourette syndrome and obsessive-compulsive disorder with allergic diseases in children and adolescents: a preliminary study.

Science.gov (United States)

Yuce, M; Guner, S N; Karabekiroglu, K; Baykal, S; Kilic, M; Sancak, R; Karabekiroglu, A

2014-01-01

To investigate the rate of allergic diseases including asthma, allergic rhinitis and eczema in children and adolescents diagnosed with obsessive-compulsive disorder (OCD) (n:26) and/or Tourette syndrome (TS) (n:32) [OCD plus TS, n:13] compared to control subjects (n:35) [total, n:80]. The symptoms of any allergic disease were assessed using the ISAAC questionnaire form. Allergy diagnoses were made by a pediatric allergy specialist. Skin prick tests were applied, and IgE levels and eosinophil counts were measured. While only one-fifth of the control subjects had allergic diseases, more than half of the children with TS and/or OCD had comorbid allergic diseases. Positive skin prick tests were greater in OCD patients compared to control subjects. There were no significant differences between the groups in terms of eosinophil counts or IgE levels. Among the allergic diseases, while allergic rhinitis was diagnosed at significantly higher rates in TS patients, eczema was significantly higher in OCD patients compared to control subjects. This preliminary study shows an association between allergic diseases and TS and/or OCD. The results revealing differences in associations between types of allergic disease (rhinitis or eczema) and neuropsychiatric disorder (tic disorder or OCD) need to be investigated in further studies with higher numbers of participants, and immune markers should be examined.

Preliminary Ecotoxicity and Biodegradability Assessment of Metalworking Fluids

Science.gov (United States)

Gerulová, Kristína; Amcha, Peter; Filická, Slávka

2010-01-01

The main aim of this study was to evaluate the potential of activated sludge from sewage treatment plant to degrade selected MWFs (ecotoxicity to bacterial consortium) and to evaluate the ecotoxicity by Lemna minor-higher plant. After evaluating the ecotoxicity, biodegradations rate with activated sludge was assessed on the basis of COD measurement. Preliminary study of measuring the ecotoxicity according to OECD 221 by Lemna minor shows effective concentration of Emulzin H at the rate of 81.6 mg l-1, for Ecocool 82.9 mg l-1, for BC 25 about 99.3 mg l-1, and for Dasnobor about 97.3 mg l-1. Preliminary study of measuring the ecotoxicity by bacterial consortium according to OECD 209 (STN EN ISO 8192) shows effective concentration of Blasocut BC 25 at the rate 227.4 mg l-1. According to OECD 302B, the biodegradations level of Emulzin H, Ecocool and BC 25 achieved 80% in 10 days. It can be stated that these MWFs have potential to ultimate degradation, but the statement has to be confirmed by a biodegradability test with other parameters than COD, which exhibits some disadvantages in testing O/W emulsions.

Development and preliminary reliability of a multitasking assessment for executive functioning after concussion.

Science.gov (United States)

Smith, Laurel B; Radomski, Mary Vining; Davidson, Leslie Freeman; Finkelstein, Marsha; Weightman, Margaret M; McCulloch, Karen L; Scherer, Matthew R

2014-01-01

OBJECTIVES. Executive functioning deficits may result from concussion. The Charge of Quarters (CQ) Duty Task is a multitask assessment designed to assess executive functioning in servicemembers after concussion. In this article, we discuss the rationale and process used in the development of the CQ Duty Task and present pilot data from the preliminary evaluation of interrater reliability (IRR). METHOD. Three evaluators observed as 12 healthy participants performed the CQ Duty Task and measured performance using various metrics. Intraclass correlation coefficient (ICC) quantified IRR. RESULTS. The ICC for task completion was .94. ICCs for other assessment metrics were variable. CONCLUSION. Preliminary IRR data for the CQ Duty Task are encouraging, but further investigation is needed to improve IRR in some domains. Lessons learned in the development of the CQ Duty Task could benefit future test development efforts with populations other than the military. Copyright © 2014 by the American Occupational Therapy Association, Inc.

Preliminary assessment report for Kent National Guard Facility (Installation 53065), 24410 Military Road, Kent, Washington

International Nuclear Information System (INIS)

Ketels, P.; Aggarwal, P.; Rose, C.M.

1993-08-01

This report presents the results of the preliminary assessment (PA) conducted by Argonne National Laboratory at the Washington Army National Guard property in Kent, Washington. Preliminary assessments of federal facilities are being conducted to compile the information necessary for completing preremedial activities and to provide a basis for establishing corrective actions in response to releases of hazardous substances. The principal objective of the PA is to characterize the site accurately and determine the need for further action by examining site activities, quantities of hazardous substances present, and potential pathways by which contamination could affect public health and the environment

Hellsgate Winter Range : Wildlife Mitigation Project. Preliminary Environmental Assessment.

Energy Technology Data Exchange (ETDEWEB)

United States. Bonneville Power Administration.

1995-01-01

The Bonneville Power Administration proposes funding the Hellsgate Winter Range Wildlife Mitigation Project in cooperation with the Colville Convederated Tribes and Bureau of Indian Affairs. This Preliminary Environmental Assessment examines the potential environmental effects of acquiring and managing property for wildlife and wildlife habitat within a large project area. The Propose action is intended to meet the need for mitigation of wildlife and wild life habitat that was adversely affected by the construction of Grand Coulee and Chief Joseph Dams and their reservoirs.

Preliminary assessment report for Fort William Henry Harrison, Montana Army National Guard, Helena, Montana

International Nuclear Information System (INIS)

DuWaldt, J.; Meyer, T.

1993-07-01

This report presents the results of the preliminary assessment (PA) conducted by Argonne National Laboratory at a Montana Army National Guard (MTARNG) property near Helena, Montana. Preliminary assessments of federal facilities are being conducted to compile the information necessary for completing preremedial activities and to provide a basis for establishing corrective actions in response to releases of hazardous substances. The principal objective of the PA is to characterize the site accurately and determine the need for further action by examining site activities, quantities of hazardous substances present, and potential pathways by which contamination could affect public health and the environment. This PA satisfies, for the Fort William Henry Harrison property, requirements of the Department of Defense Installation Restoration Program

Comments on SKB's SFL 3-5 preliminary performance assessment

International Nuclear Information System (INIS)

Wilmot, R.D.; Crawford, M.B.

2000-01-01

Recently introduced regulations in Sweden have established an individual risk criterion ( -6 per year) for the long-term performance of repositories for the disposal of radioactive wastes. SKB has not focused its assessment of SFL 3-5 on demonstrating compliance with this regulation. Instead, SKB has calculated individual dose and provided a comparison with an annual individual dose of 14 iSv (derived from the risk criteria using the ICRP's dose-risk conversion factor of 0.073 per Sv). The justification of this approach is that probabilities do not need to be determined if doses are less than the dose equivalent to the risk criterion. However, there is insufficient information regarding uncertainty provided in the documentation of the SFL 3-5 assessment to determine whether this approach is reasonable. SKB's parallel assessment of a repository for spent fuel using the KBS-3 concept (SR 97) accounts for uncertainty by specifying a 'reasonable' and a 'pessimistic' value for uncertain parameters in the assessment calculations. Although there are problems with the way probabilities have been assigned to these values, this approach does indicate where there are significant uncertainties. The SFL 3-5 PA does not include a structured approach to defining uncertainty, although a number of assumptions and parameter values are stated to be conservative. As a preliminary assessment, there is insufficient information to identify key uncertainties or sensitivities, or to determine where further work should be focused. Any assessment requires the use of expert judgement to determine how the assessment is conducted, what modelling approach to use, what features, events and processes (FEPs) could potentially affect the disposal system, which FEPs should be included in the conceptual models, and which scenarios should be assessed. Judgements are also required in determining how to parameterize the models, and this may extend to formal expert elicitation for particular parameter

Preliminary regulatory assessment of nuclear power plants vulnerabilities

International Nuclear Information System (INIS)

Kostadinov, V.; Petelin, S.

2004-01-01

Preliminary attempts to develop models for nuclear regulatory vulnerability assessment of nuclear power plants are presented. Development of the philosophy and computer tools could be new and important insight for management of nuclear operators and nuclear regulatory bodies who face difficult questions about how to assess the vulnerability of nuclear power plants and other nuclear facilities to external and internal threats. In the situation where different and hidden threat sources are dispersed throughout the world, the assessment of security and safe operation of nuclear power plants is very important. Capability to evaluate plant vulnerability to different kinds of threats, like human and natural occurrences and terrorist attacks and preparation of emergency response plans and estimation of costs are of vital importance for assurance of national security. On the basis of such vital insights, nuclear operators and nuclear regulatory bodies could plan and optimise changes in oversight procedures, organisations, equipment, hardware and software to reduce risks taking into account security and safety of nuclear power plants operation, budget, manpower, and other limitations. Initial qualitative estimations of adapted assessments for nuclear applications are shortly presented. (author)

A preliminary social and economic assessment of the Basalt Waste Isolation Project

International Nuclear Information System (INIS)

Cluett, C.; Bolton, P.; York, K.; Wood, M.; Radford, L.

1981-07-01

This report provides a preliminary assessment of the social and economic impacts that could be caused by the construction and operation of a nuclear waste repository on the Hanford Site near Richland, Washington. This assessment involved assembling a comprehensive data base for the local Tri-Cities impact area and the surrounding region, establishing a network of local and regional contacts, making preliminary judgments about potential social impacts caused by the proposed repository, and recommending further research. This report concludes that growth effects under the anticipated work force scenario are expected to be relatively minor. With a strong public involvement program on the part of the project developers, including an ongoing dialogue with local and regional planners, potential socio-economic impacts can be anticipated and managed effectively. Specific recommendations are made for filling gaps in the available data, exploring key issues in more detail, and improving the analysis of social impacts. The report was prepared by the Battelle-Human Affairs Research Center in 1980 and 1981

Preliminary assessment report for Fort Custer Training Center, Installation 26035, Augusta, Michigan

International Nuclear Information System (INIS)

Flaim, S.; Krokosz, M.

1993-08-01

This report presents the results of the preliminary assessment (PA) conducted by Argonne National Laboratory at the Michigan Army National Guard property near Augusta, Michigan. Preliminary assessments of federal facilities are being conducted to compile the information necessary for completing preremedial activities and to provide a basis for establishing corrective actions in response to releases of hazardous substances. The principal objective of the PA is to characterize the site accurately and determine the need for further action by examining site activities, quantities of hazardous substances present, and potential pathways by which contamination could affect public health and the environment. This PA satisfies, for the Fort Custer Training Center, phase I of the Department of Defense Installation Restoration Program. The environmentally significant operations associated with the property are (1) storage of hazardous materials and hazardous waste, (2) storage and dispensing of fuel, (3) washing of vehicles and equipment, and (4) weapons training ranges that may have accumulated lead

78 FR 14540 - Chlorpyrifos Registration Review; Preliminary Volatilization Assessment; Extension of Comment Period

Science.gov (United States)

2013-03-06

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2008-0850; FRL-9380-7] Chlorpyrifos Registration... Federal Register issue of February 6, 2013, concerning Chlorpyrifos Registration Review; Preliminary... volatilization assessment for the registration review of chlorpyrifos. EPA received requests from several...

Preliminary environmental assessment for the satellite power system (SPS)

Energy Technology Data Exchange (ETDEWEB)

1978-10-01

A preliminary assessment of the impact of the Satellite Power System (SPS) on the environment is presented. Information that has appeared in documents referenced herein is integrated and assimilated. The state-of-knowledge as perceived from recently completed DOE-sponsored studies is disclosed, and prospective research and study programs that can advance the state-of-knowledge and provide an expanded data base for use in an assessment planned for 1980 are defined. Alternatives for research that may be implemented in order to achieve this advancement are also discussed in order that a plan can be selected which will be consistent with the fiscal and time constraints on the SPS Environmental Assessment Program. Health and ecological effects of microwave radiation, nonmicrowave effects on health and the environment (terrestrial operations and space operations), effects on the atmosphere, and effects on communications systems are examined in detail. (WHK)

Fukushima. A preliminary assessment in July 2011; Fukushima. Eine vorlaeufige Bilanz im Juli 2011

Energy Technology Data Exchange (ETDEWEB)

Michel, Rolf

2011-07-01

Four months after the reactor accidents in Fukushima Daiichi a preliminary assessment of the accident sequence vents is performed based on the available incomplete information. The following topics are discussed: initiating events and accident sequences, radioactive materials release and dispersion, fundamentals on radiation exposure following the accident in the nuclear power plant Fukushima Daiichi, contamination of food stuff, fission product release into the Pacific Ocean, source tern and external radiation exposure in the first year, preliminary radiological assessment, radiological situation throughout the different accident phases (radioactive cloud and fallout, late phase), estimation of radiation exposure in the first year due to decay of short-lived radionuclides based on the state end of July 2011, comparison of the reactor accidents in Chernobyl and Fukushima Daiichi.

A preliminary assessment of the true morels (Morchella) in Newfoundland and Labrador

Science.gov (United States)

A preliminary assessment of true morels (Morchella) from Newfoundland and Labrador (NL) was obtained by using DNA sequence data from portions of three genes to identify 20 collections from Newfoundland and one from a remote location in Labrador. To place this work in a broader context, data on 25 co...

High-dose-rate stereotactic body radiation therapy for postradiation therapy locally recurrent prostatic carcinoma: Preliminary prostate-specific antigen response, disease-free survival, and toxicity assessment.

Science.gov (United States)

Fuller, Donald B; Wurzer, James; Shirazi, Reza; Bridge, Stephen S; Law, Jonathan; Mardirossian, George

2015-01-01

Patients with locally recurrent adenocarcinoma of the prostate following radiation therapy (RT) present a challenging problem. We prospectively evaluated the use of "high-dose-rate-like" prostate stereotactic body RT (SBRT) salvage for this circumstance, evaluating prostate-specific antigen response, disease-free survival, and toxicity. Between February 2009 and March 2014, 29 patients with biopsy-proven recurrent locally prostate cancer >2 years post-RT were treated. Median prior RT dose was 73.8 Gy and median interval to SBRT salvage was 88 months. Median recurrence Gleason score was 7 (79% was ≥7). Pre-existing RT toxicity >grade 1 was a reason for exclusion. Magnetic resonance imaging-defined prostate volume including any suspected extraprostatic extension, comprising the planning target volume. A total of 34 Gy/5 fractions was given, delivering a heterogeneous, high-dose-rate-like dose-escalation pattern. Toxicities were assessed using Common Terminology Criteria for Adverse Events, version 3.0, criteria. Twenty-nine treated patients had a median 24-month follow-up (range, 3-60 months). A median pre-SBRT salvage baseline prostate-specific antigen level of 3.1 ng/mL decreased to 0.65 ng/mL and 0.16 ng/mL at 1 and 2 years, respectively. Actuarial 2-year biochemical disease-free survival measured 82%, with no local failures. Toxicity >grade 1 was limited to the genitourinary domain, with 18% grade 2 or higher and 7% grade 3 or higher. No gastrointestinal toxicity >grade 1 occurred. Two-year disease-free survival is encouraging, and the prostate-specific antigen response kinetic appears comparable with that seen in de novo patients treated with SBRT, albeit still a preliminary finding. Grade ≥2 genitourinary toxicity was occasionally seen with no obvious predictive factor. Noting that our only brachytherapy case was 1 of the 2 cases with ≥grade 3 genitourinary toxicity, caution is recommended treating these patients. SBRT salvage of post-RT local recurrence

Criteria for safety-related nuclear plant operator actions: a preliminary assessment of available data

International Nuclear Information System (INIS)

Haas, P.M.; Bott, T.F.

1980-01-01

In the US, an effort has been underway for a number of years to develop a design standard to define when required manual operator action can be accepted as part of a nuclear plant design basis. Insufficient data are available to provide quantitative guidelines for the standard. To provide the necessary data base to support such standards and the necessary quantitative assessment of operator reliability, the US Nuclear Regulatory Commission is sponsoring a study at Oak National Laboratory to develop the data base. A preliminary assessment completed in April, 1979 concluded that sufficient data from US operating experience did not exist to provide an adequate data base. A program of research using full-scope nuclear plant simulators and results that are correlated to field data was suggested. That program was recently initiated. The approach, results and conclusions of the preliminary assessment are reviewed and the planned research program of simulator studies is summarised. (author)

Preliminary geological suitability assessment for LILW disposal

International Nuclear Information System (INIS)

Tomse, P.; Mele, I.

2001-01-01

Due to the growing need for a final disposal of LILW, the final solution for the short-lived LILW is the key issue of radioactive waste management in Slovenia at the moment. ARAO - the Slovenian Agency for Radwaste Management - is intensely involved in the re-initiated site selection process for a LILW repository. In this new process we are trying to combine as best as possible the technical, geologically-led and the advocacy-site selection processes. By a combination of technical and volunteer approach to the site selection we wish to guarantee high public involvement and sufficient flexibility of the process to adapt to specific conditions or new circumstances while the project is ongoing. In the technical phase, our tendency is to retain a larger number of potential areas/sites. We also keep open the possibility of choosing the type of repository. The decision between the surface and underground option will be made only once the site has been defined. In accordance with the IAEA recommendations the site selection process is divided into four stages: the conceptual and planning stage, area survey stage, site characterisation stage and site confirmation stage. Last year the area survey stage was started. In the preliminary geological suitability assessment the required natural predisposition of Slovene territory was assessed in order to locate geologically suitable formations. The assessment of natural conditions of the system was based on consideration of the main geological, hydro-geological and seismotectonic conditions. It was performed with ARC/INFO technology. The results are compiled in a map, showing potential areas for underground and surface disposal of LILW in Slovenia. It has been established that there is a potential suitability for both surface and underground disposal on about 10 000 km 2 of the Slovenian territory, which represents almost half of the entire Slovenian territory. These preliminary results are now being carefully re-examined. As an

Guidance for performing preliminary assessments under CERCLA

Energy Technology Data Exchange (ETDEWEB)

NONE

1991-09-01

EPA headquarters and a national site assessment workgroup produced this guidance for Regional, State, and contractor staff who manage or perform preliminary assessments (PAs). EPA has focused this guidance on the types of sites and site conditions most commonly encountered. The PA approach described in this guidance is generally applicable to a wide variety of sites. However, because of the variability among sites, the amount of information available, and the level of investigative effort required, it is not possible to provide guidance that is equally applicable to all sites. PA investigators should recognize this and be aware that variation from this guidance may be necessary for some sites, particularly for PAs performed at Federal facilities, PAs conducted under EPA`s Environmental Priorities Initiative (EPI), and PAs at sites that have previously been extensively investigated by EPA or others. The purpose of this guidance is to provide instructions for conducting a PA and reporting results. This guidance discusses the information required to evaluate a site and how to obtain it, how to score a site, and reporting requirements. This document also provides guidelines and instruction on PA evaluation, scoring, and the use of standard PA scoresheets. The overall goal of this guidance is to assist PA investigators in conducting high-quality assessments that result in correct site screening or further action recommendations on a nationally consistent basis.

A preliminary assessment of radiation effects on American Flagfish

Energy Technology Data Exchange (ETDEWEB)

Tzivaki, M.; Waller, E., E-mail: margarita.tzivaki@uoit.ca [University of Ontario Institute of Technology, Oshawa, ON (Canada)

2015-07-01

In order to add to the knowledge base of radiation effects on non-human biota, it is important to define benchmark values for different species. An experimental set-up was designed to investigate effects from irradiation with Cs-137 to American Flagfish. Preliminary experiments to assess the suitability of the methodology were conducted by exposing Flagfish eggs to 44 h of ionizing radiation. The subsequent observation of the developing fry showed no effect on hatching. However, the mortality and observed vertebral malformations were increased with increasing absorbed dose which is suspected to be a result of developmental defects in the embryonic stage. (author)

Preliminary bioelectrical impedance analysis (BIA) equation for body composition assessment in young females from Colombia

International Nuclear Information System (INIS)

Caicedo, J C; González-Correa, C H; González-Correa, C A

2013-01-01

A previous study showed that reported BIA equations for body composition are not suitable for Colombian population. The purpose of this study was to develop and validate a preliminary BIA equation for body composition assessment in young females from Colombia, using hydrodensitometry as reference method. A sample of 30 young females was evaluated. Inclusion and exclusion criteria were defined to minimize the variability of BIA. Height, weight, BIA, residual lung volume (RV) and underwater weight (UWW) were measured. A preliminary BIA equation was developed (r 2 = 0.72, SEE = 2.48 kg) by stepwise multiple regression with fat-free mass (FFM) as dependent variable and weight, height and impedance measurements as independent variables. The quality of regression was evaluated and a cross-validation against 50% of sample confirmed that results obtained with the preliminary BIA equation is interchangeable with results obtained with hydrodensitometry (r 2 = 0.84, SEE = 2.62 kg). The preliminary BIA equation can be used for body composition assessment in young females from Colombia until a definitive equation is developed. The next step will be increasing the sample, including a second reference method, as deuterium oxide dilution (D 2 O), and using multi-frequency BIA (MF-BIA). It would also be desirable to develop equations for males and other ethnic groups in Colombia.

Preliminary assessment report for Redmond Army National Guard Facility, Installation 53120, Redmond, Washington

International Nuclear Information System (INIS)

Ketels, P.; Aggarwal, P.

1993-08-01

This report presents the results of the preliminary assessment (PA) conducted by Argonne National Laboratory at the Washington Army National Guard (WAARNG) property in Redmond, Washington. Preliminary assessments of federal facilities are being conducted to compile the information necessary for completing preremedial activities and to provide a basis for establishing corrective actions in response to releases of hazardous substances. The principal objective of the PA is to characterize the site accurately and determine the need for further action by examining site activities, quantities of hazardous substances present, and potential pathways by which contamination could affect public health and the environment. This PA satisfies, for the Redmond ARNG property, Phase I of the Department of Defense Installation Restoration Program. The environmentally significant operations (ESOs) associated with the property are (1) supply/storage of hazardous materials, (2) weapons cleaning, (3) the underground storage tanks (USTs), and (4) the use of herbicides. These ESOs are no longer active because of the closure of OMS 10 activities in 1988

Preliminary assessment of risk of ozone impacts to maize (Zea mays) in Southern Africa

CSIR Research Space (South Africa)

Van Tienhoven, AM

2006-03-01

Full Text Available Surface ozone concentrations in southern Africa exceed air quality guidelines set to protect agricultural crops. This paper addresses a knowledge gap by performing a preliminary assessment of potential ozone impacts on vegetation in southern African...

Preliminary Performance Assessment for Disposal of APT and CLWR/TEF Wastes at SRS

International Nuclear Information System (INIS)

Wilhite, E.L.

1998-01-01

This section provides the descriptive information for understanding the analyses presented in this preliminary performance assessment. This section addresses the approach taken in the PA, provides a general description of the Savannah River Site E-Area low-level waste facility, and discusses the performance criteria used for evaluating performance

76 FR 52945 - Chlorpyrifos Registration Review; Preliminary Human Health Risk Assessment; Extension of Comment...

Science.gov (United States)

2011-08-24

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2008-0850; FRL-8886-6] Chlorpyrifos Registration... chlorpyrifos registration review; preliminary human health risk assessment. This document extends the comment... . SUPPLEMENTARY INFORMATION: This document extends the public comment period for the chlorpyrifos reregistration...

Criteria for safety related nuclear plant operator actions: a preliminary assessment of available data

International Nuclear Information System (INIS)

Haas, P.M.; Bott, T.F.

1982-01-01

The need for a quantitative data base on the reliability of nuclear power plant operators has long been recognised by human factors and reliability analysts, and the great need for further assessment of operator performance under accident conditions has been dramatically emphasised by the incident at Three Mile Island-2. In the US, an effort has been under way for a number of years to develop a design standard to define when required manual operator action can be accepted as part of a nuclear plant design basis. To provide the necessary data base to support such standards and the necessary quantitative assessment of operator reliability, the US Nuclear Regulatory Commission is sponsoring a study at Oak Ridge National Laboratory to develop the data base. A preliminary assessment, completed in April 1979, concluded that sufficient data from US operating experience did not exist to provide an adequate data base. A programme of research using full-scope nuclear plant simulators and results that are correlated to field data was suggested. That programme was recently initiated. This paper reviews the approach, results and conclusions of the preliminary assessment and summarises the planned research programme of simulator studies. (author)

Assessment of patient experience with unilateral vocal fold immobility: a preliminary study.

Science.gov (United States)

Francis, David O; McKiever, Monique E; Garrett, C Gaelyn; Jacobson, Barbara; Penson, David F

2014-09-01

Systematically moving toward patient-centered care for unilateral vocal fold immobility (UVFI) requires comprehensive understanding of the variability of actual patient experiences. This rigorous qualitative study assesses UVFI-related disability and proposes a preliminary taxonomy of UVFI patient experience. (1) Semistructured interviews and (2) taxonomy development. Consecutive UVFI patients presenting July to September, 2012, prospectively underwent open-ended interviews investigating how UVFI affected their quality of life (QOL) and had caused disability. Comments reported by >20% were synthesized into axes based on content similarity. Variables were arranged into a preliminary taxonomy of UVFI patient experience, which was evaluated for four attributes of face validity. The majority of 39 patients had "extensive" baseline voice use (56%) and an iatrogenic etiology (62%). Taxonomy of patient experience included three main axes of symptomatic classification: (1) voice, (2) swallowing, and (3) breathing-all with intrinsic (physical and emotional) and extrinsic (social) subaxes that describe major impacts on QOL. Voice complaints were 100% penetrant, whereas breathing and swallowing symptoms afflicted 76% and 66%, respectively, of interviewees. Of affected patients, solid and liquid dysphagia was experienced by 70% and 63%, respectively. Of dyspneic patients, shortness of breath existed with talking (97%) and exercise (72%). Persistent throat congestion (76%), weakened cough (62%), globus (62%), and dysfunctional valsalva (41%) were frequent. Patient experience with UVFI has been incompletely characterized. This qualitative assessment and preliminary taxonomy highlight several related patient experiences not well documented in the literature or incorporated into currently available metrics. Copyright © 2014 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

Preliminary performance assessment for the Waste Isolation Pilot Plant, December 1992. Volume 3, Model parameters: Sandia WIPP Project

Energy Technology Data Exchange (ETDEWEB)

1992-12-29

This volume documents model parameters chosen as of July 1992 that were used by the Performance Assessment Department of Sandia National Laboratories in its 1992 preliminary performance assessment of the Waste Isolation Pilot Plant (WIPP). Ranges and distributions for about 300 modeling parameters in the current secondary data base are presented in tables for the geologic and engineered barriers, global materials (e.g., fluid properties), and agents that act upon the WIPP disposal system such as climate variability and human-intrusion boreholes. The 49 parameters sampled in the 1992 Preliminary Performance Assessment are given special emphasis with tables and graphics that provide insight and sources of data for each parameter.

Motor assessment in Parkinson`s disease.

Science.gov (United States)

Opara, Józef; Małecki, Andrzej; Małecka, Elżbieta; Socha, Teresa

2017-09-21

Parkinson's disease (PD) is one of most disabling disorders of the central nervous system. The motor symptoms of Parkinson's disease: shaking, rigidity, slowness of movement, postural instability and difficulty with walking and gait, are difficult to measure. When disease symptoms become more pronounced, the patient experiences difficulties with hand function and walking, and is prone to falls. Baseline motor impairment and cognitive impairment are probable predictors of more rapid motor decline and disability. An additional difficulty is the variability of the symptoms caused by adverse effects of drugs, especially levodopa. Motor assessment of Parkinson`s Disease can be divided into clinimetrics, assessment of balance and posture, arm and hand function, and gait/walking. These are many clinimetric scales used in Parkinson`s Disease, the most popular being the Hoehn and Yahr stages of progression of the disease and Unified Parkinson's Disease Rating Scale. Balance and posture can be assessed by clinimetric scales like the Berg BS, Tinetti, Brunel BA, and Timed Up and Go Test, or measured by posturometric platforms. Among skill tests, the best known are: the Purdue Pegboard Test, Nine-Hole Peg Test, Jebsen and Taylor test, Pig- Tail Test, Frenchay Arm Test, Action Research Arm Test, Wolf FMT and Finger-Tapping Test. Among motricity scales, the most popular are: the Fugl-Meyer Motor Assessment Scale and Södring Motor Evaluation. Gait and walking can also be assessed quantitatively and qualitatively. Recently, the most popular is three-dimensional analysis of movement. This review article presents the current possibilities of motor assessment in Parkinson`s disease.

Risk Assessment of Healthcare Waste by Preliminary Hazard Analysis Method

Directory of Open Access Journals (Sweden)

Pouran Morovati

2017-09-01

Full Text Available Introduction and purpose: Improper management of healthcare waste (HCW can pose considerable risks to human health and the environment and cause serious problems in developing countries such as Iran. In this study, we sought to determine the hazards of HCW in the public hospitals affiliated to Abadan School of Medicine using the preliminary hazard analysis (PHA method. Methods: In this descriptive and analytic study, health risk assessment of HCW in government hospitals affiliated to Abadan School of Medicine (4 public hospitals was carried out by using PHA in the summer of  2016. Results: We noted the high risk of sharps and infectious wastes. Considering the dual risk of injury and disease transmission, sharps were classified in the very high-risk group, and pharmaceutical and chemical and radioactive wastes were classified in the medium-risk group. Sharps posed the highest risk, while pharmaceutical and chemical wastes had the lowest risk. Among the various stages of waste management, the waste treatment stage was the most hazardous in all the studied hospitals. Conclusion: To diminish the risks associated with healthcare waste management in the studied hospitals, adequate training of healthcare workers and care providers, provision of suitable personal protective and transportation equipment, and supervision of the environmental health manager of hospitals should be considered by the authorities.  

Preliminary dose assessment of the Chernobyl accident

International Nuclear Information System (INIS)

Hull, A.P.

1987-01-01

From the major accident at Unit 4 of the Chernobyl nuclear power station, a plume of airborne radioactive fission products was initially carried northwesterly toward Poland, thence toward Scandinavia and into Central Europe. Reports of the levels of radioactivity in a variety of media and of external radiation levels were collected in the Department of Energy's Emergency Operations Center and compiled into a data bank. Portions of these and other data which were obtained directly from published and official reports were utilized to make a preliminary assessment of the extent and magnitude of the external dose to individuals downwind from Chernobyl. Radioactive 131 I was the predominant fission product. The time of arrival of the plume and the maximum concentrations of 131 I in air, vegetation and milk and the maximum reported depositions and external radiation levels have been tabulated country by country. A large amount of the total activity in the release was apparently carried to a significant elevation. The data suggest that in areas where rainfall occurred, deposition levels were from ten to one-hundred times those observed in nearby ''dry'' locations. Sufficient spectral data were obtained to establish average release fractions and to establish a reference spectra of the other nuclides in the release. Preliminary calculations indicated that the collective dose equivalent to the population in Scandinavia and Central Europe during the first year after the Chernobyl accident would be about 8 x 10 6 person-rem. From the Soviet report, it appears that a first year population dose of about 2 x 10 7 person-rem (2 x 10 5 Sv) will be received by the population who were downwind of Chernobyl within the U.S.S.R. during the accident and its subsequent releases over the following week. 32 refs., 14 figs., 20 tabs

Effectiveness of diffusion tensor imaging in assessing disease severity in Duchenne muscular dystrophy: preliminary study

International Nuclear Information System (INIS)

Ponrartana, Skorn; Hu, Houchun Harry; Ramos-Platt, Leigh; Wren, Tishya Anne Leong; Gilsanz, Vicente; Perkins, Thomas Gardner; Chia, Jonathan Mawlin

2015-01-01

There is currently a lack of suitable objective endpoints to measure disease progression in Duchenne muscular dystrophy (DMD). Emerging research suggests that diffusion tensor imaging (DTI) has potential as an outcome measure for the evaluation of skeletal muscle injury. The objective of this study was to evaluate the potential of DTI as quantitative magnetic resonance imaging (MRI) markers of disease severity in DMD. Thirteen consecutive boys (8.9 years ± 3.0 years) with DMD were evaluated using DTI. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were compared with clinical outcome measures of manual muscle testing and MRI determinations of muscle fat fraction (MFF) in the right lower extremity. Both MRI measures of FA and ADC strongly correlated with age and muscle strength. Values for FA positively correlated with age and negatively correlated with muscle strength (r = 0.78 and -0.96; both P ≤ 0.002) while measures of ADC negatively correlated age, but positively correlated with muscle strength (r = -0.87 and 0.83; both P ≤ 0.0004). Additionally, ADC and FA strongly correlated with MFF (r = -0.891 and 0.894, respectively; both P ≤ 0.0001). Mean MMF was negatively correlated with muscle strength (r = -0.89, P = 0.0001). DTI measures of muscle structure strongly correlated with muscle strength and adiposity in boys with DMD in this pilot study, although these markers may be more reflective of fat replacement rather than muscle damage in later stages of the disease. Further studies in presymptomatic younger children are needed to assess the ability of DTI to detect early changes in DMD. (orig.)

Effectiveness of diffusion tensor imaging in assessing disease severity in Duchenne muscular dystrophy: preliminary study

Energy Technology Data Exchange (ETDEWEB)

Ponrartana, Skorn; Hu, Houchun Harry [Children' s Hospital Los Angeles, Department of Radiology, Los Angeles, CA (United States); Ramos-Platt, Leigh [Children' s Hospital Los Angeles, Department of Neurology, Los Angeles, CA (United States); Wren, Tishya Anne Leong; Gilsanz, Vicente [Children' s Hospital Los Angeles, Department of Radiology, Los Angeles, CA (United States); Children' s Hospital Los Angeles, Department of Orthopaedic Surgery, Los Angeles, CA (United States); Perkins, Thomas Gardner; Chia, Jonathan Mawlin [Philips Healthcare North America, Cleveland, OH (United States)

2015-04-01

There is currently a lack of suitable objective endpoints to measure disease progression in Duchenne muscular dystrophy (DMD). Emerging research suggests that diffusion tensor imaging (DTI) has potential as an outcome measure for the evaluation of skeletal muscle injury. The objective of this study was to evaluate the potential of DTI as quantitative magnetic resonance imaging (MRI) markers of disease severity in DMD. Thirteen consecutive boys (8.9 years ± 3.0 years) with DMD were evaluated using DTI. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were compared with clinical outcome measures of manual muscle testing and MRI determinations of muscle fat fraction (MFF) in the right lower extremity. Both MRI measures of FA and ADC strongly correlated with age and muscle strength. Values for FA positively correlated with age and negatively correlated with muscle strength (r = 0.78 and -0.96; both P ≤ 0.002) while measures of ADC negatively correlated age, but positively correlated with muscle strength (r = -0.87 and 0.83; both P ≤ 0.0004). Additionally, ADC and FA strongly correlated with MFF (r = -0.891 and 0.894, respectively; both P ≤ 0.0001). Mean MMF was negatively correlated with muscle strength (r = -0.89, P = 0.0001). DTI measures of muscle structure strongly correlated with muscle strength and adiposity in boys with DMD in this pilot study, although these markers may be more reflective of fat replacement rather than muscle damage in later stages of the disease. Further studies in presymptomatic younger children are needed to assess the ability of DTI to detect early changes in DMD. (orig.)

A selective egocentric topographical working memory deficit in the early stages of Alzheimer's disease: a preliminary study.

Science.gov (United States)

Bianchini, F; Di Vita, A; Palermo, L; Piccardi, L; Blundo, C; Guariglia, C

2014-12-01

The aim of this study was to determine whether an egocentric topographical working memory (WM) deficit is present in the early stages of Alzheimer's disease (AD) with respect to other forms of visuospatial WM. Further, we would investigate whether this deficit could be present in patients having AD without topographical disorientation (TD) signs in everyday life assessed through an informal interview to caregivers. Seven patients with AD and 20 healthy participants performed the Walking Corsi Test and the Corsi Block-Tapping Test. The former test requires memorizing a sequence of places by following a path and the latter is a well-known visuospatial memory task. Patients with AD also performed a verbal WM test to exclude the presence of general WM impairments. Preliminary results suggest that egocentric topographical WM is selectively impaired, with respect to visuospatial and verbal WM, even without TD suggesting an important role of this memory in the early stages of AD. © The Author(s) 2014.

Transplanting the Body: Preliminary Ethical Considerations.

Science.gov (United States)

Miller, Lantz Fleming

2017-11-01

A dissociated area of medical research warrants bioethical consideration: a proposed transplantation of a donor's entire body, except head, to a patient with a fatal degenerative disease. The seeming improbability of such an operation can only underscore the need for thorough bioethical assessment: Not assessing a case of such potential ethical import, by showing neglect instead of facing the issue, can only compound the ethical predicament, perhaps eroding public trust in ethical medicine. This article discusses the historical background of full-body transplantation, documents the seriousness of its current pursuit, and builds an argument for why prima facie this type of transplant is bioethically distinct. Certainly, this examination can only be preliminary, indicating what should be a wide and vigorous discussion among practitioners and ethicists. It concludes with practical suggestions for how the medical and bioethics community may proceed with ethical assessment.

Preliminary assessment of sponge biodiversity on Saba Bank, Netherlands Antilles.

Directory of Open Access Journals (Sweden)

Robert W Thacker

Full Text Available BACKGROUND: Saba Bank Atoll, Netherlands Antilles, is one of the three largest atolls on Earth and provides habitat for an extensive coral reef community. To improve our knowledge of this vast marine resource, a survey of biodiversity at Saba Bank included a multi-disciplinary team that sampled fishes, mollusks, crustaceans, macroalgae, and sponges. METHODOLOGY/PRINCIPAL FINDINGS: A single member of the dive team conducted surveys of sponge biodiversity during eight dives at six locations, at depths ranging from 15 to 30 m. This preliminary assessment documented the presence of 45 species pooled across multiple locations. Rarefaction analysis estimated that only 48 to 84% of species diversity was sampled by this limited effort, clearly indicating a need for additional surveys. An analysis of historical collections from Saba and Saba Bank revealed an additional 36 species, yielding a total of 81 sponge species recorded from this area. CONCLUSIONS/SIGNIFICANCE: This observed species composition is similar to that found on widespread Caribbean reefs, indicating that the sponge fauna of Saba Bank is broadly representative of the Caribbean as a whole. A robust population of the giant barrel sponge, Xestospongia muta, appeared healthy with none of the signs of disease or bleaching reported from other Caribbean reefs; however, more recent reports of anchor chain damage to these sponges suggests that human activities can have dramatic impacts on these communities. Opportunities to protect this extremely large habitat should be pursued, as Saba Bank may serve as a significant reservoir of sponge species diversity.

Assessing internet addiction using the parsimonious internet addiction components model—A preliminary study.

OpenAIRE

Kuss, D.J.; Shorter, G.W.; Rooij, A.J. van; Griffiths, M.D.; Schoenmakers, T.M.

2014-01-01

Internet usage has grown exponentially over the last decade. Research indicates that excessive Internet use can lead to symptoms associated with addiction. To date, assessment of potential Internet addiction has varied regarding populations studied and instruments used, making reliable prevalence estimations difficult. To overcome the present problems a preliminary study was conducted testing a parsimonious Internet addiction components model based on Griffiths’ addiction components (Journal ...

Preliminary Shielding Assessment for the IFF System in the RAON Heavy-ion Facility

International Nuclear Information System (INIS)

Lee, Cheol Woo; Lee, Youngouk; Kim, Jong Won; Kim, Mijung

2014-01-01

A heavy-ion accelerator facility is under a development in Korea to use in the basic science research and various application areas. In this facility, the In-Flight Fragment (IFF) target and isotope separator has been designed to produce various isotopes and transport the interesting isotopes into the experimental rooms. In this work, preliminary radiation shielding assessment was performed for the IFF target room

Preliminary assessment of the controlled release of radionuclides from waste packages containing borosilicate waste glass

International Nuclear Information System (INIS)

Strachan, D.M.; McGrail, B.P.; Apted, M.J.; Engle, D.W.; Eslinger, P.W.

1990-06-01

The purpose of this report is to provide a preliminary assessment of the release-rate for an engineered barriers subsystem (EBS) containing waste packages of defense high-level waste borosilicate glass at geochemical and hydrological conditions similar to the those at Yucca Mountain. The relationship between the proposed Waste Acceptance Preliminary Specifications (WAPS) test of glass- dissolution rate and compliance with the NRC's release-rate criterion is also evaluated. Calculations are reported for three hierarchical levels: EBS analysis, waste-package analysis, and waste-glass analysis. The following conclusions identify those factors that most acutely affect the magnitude of, or uncertainty in, release-rate performance

A preliminary diffusional kurtosis imaging study of Parkinson disease: comparison with conventional diffusion tensor imaging

Energy Technology Data Exchange (ETDEWEB)

Kamagata, Koji; Kamiya, Kouhei; Suzuki, Michimasa; Hori, Masaaki; Yoshida, Mariko; Aoki, Shigeki [Juntendo University School of Medicine, Department of Radiology, Bunkyo-ku, Tokyo (Japan); Tomiyama, Hiroyuki; Hatano, Taku; Motoi, Yumiko; Hattori, Nobutaka [Juntendo University School of Medicine, Department of Neurology, Tokyo (Japan); Abe, Osamu [Nihon University School of Medicine, Department of Radiology, Tokyo (Japan); Shimoji, Keigo [National Center of Neurology and Psychiatry Hospital, Department of Radiology, Tokyo (Japan)

2014-03-15

Diffusional kurtosis imaging (DKI) is a more sensitive technique than conventional diffusion tensor imaging (DTI) for assessing tissue microstructure. In particular, it quantifies the microstructural integrity of white matter, even in the presence of crossing fibers. The aim of this preliminary study was to compare how DKI and DTI show white matter alterations in Parkinson disease (PD). DKI scans were obtained with a 3-T magnetic resonance imager from 12 patients with PD and 10 healthy controls matched by age and sex. Tract-based spatial statistics were used to compare the mean kurtosis (MK), mean diffusivity (MD), and fractional anisotropy (FA) maps of the PD patient group and the control group. In addition, a region-of-interest analysis was performed for the area of the posterior corona radiata and superior longitudinal fasciculus (SLF) fiber crossing. FA values in the frontal white matter were significantly lower in PD patients than in healthy controls. Reductions in MK occurred more extensively throughout the brain: in addition to frontal white matter, MK was lower in the parietal, occipital, and right temporal white matter. The MK value of the area of the posterior corona radiata and SLF fiber crossing was also lower in the PD group. DKI detects changes in the cerebral white matter of PD patients more sensitively than conventional DTI. In addition, DKI is useful for evaluating crossing fibers. By providing a sensitive index of brain pathology in PD, DKI may enable improved monitoring of disease progression. (orig.)

Preliminary assessment report for Grubbs/Kyle Training Center, Smyrna/Rutherford County Regional Airport, Installation 47340, Smyrna, Tennessee

International Nuclear Information System (INIS)

Dennis, C.; Stefano, J.

1993-07-01

This report presents the results of the preliminary assessment (PA) conducted by Argonne National Laboratory at the Tennessee Army National Guard (TNARNG) property near Smyrna, Tennessee. Preliminary assessments of federal facilities are being conducted to compile the information necessary for completing preremedial activities and to provide a basis for establishing corrective actions in response to releases of hazardous substances. The principal objective of the PA is to characterize the site accurately and determine the need for further action by examining site activities, quantities of hazardous substances present, and potential pathways by which contamination could affect public health and the environment. This PA satisfies, for the Grubbs/Kyle Training Center property, the requirement of the Department of Defense Installation Restoration Program

Preliminary assessment of the possibility of supporting the decomposition of biodegradable packaging

OpenAIRE

Niekraś Lidia; Moliszewska Ewa

2017-01-01

This article presents a preliminary evaluation of the possibility of using grass biomass from a sports field as a compost ingredient which positively affects the degree of decomposition of the biodegradable wrappings. For 5 months the biodegradable bags were stored, both empty and filled with organic waste in the heap of grass clippings. After that period, fragments of the bags were observed under the microscope and then assessed the state of their decomposition. The results indicate that the...

Preliminary assessment of fleets covered by the Energy Policy Act

Energy Technology Data Exchange (ETDEWEB)

Hu, P.S.; Davis, S.C.; Wang, M.Q. [and others

1994-12-31

To facilitate the goal of decreasing oil imports by 10 percent by the year 2000 and 30 percent by 2010, two sections of the Energy Policy Act encourage and mandate alternative fuel vehicles in the acquisition of fleet vehicles. The first step in estimating the contribution of these mandates toward meeting the aforementioned goal entails identifying affected fleets. This paper presents a preliminary assessment of potential vehicle fleet coverage. Only a limited number of companies in the methanol, ethanol, and hydrogen industries are likely to quality for this mandate. Whereas, many of the oil producers, petroleum refiners, and electricity companies are likely to be regulated.

Difficulty in Assessing Quality of Life Outcomes in a Fluctuating Disease: A Hypothesis Based on Gastroparesis

Directory of Open Access Journals (Sweden)

Vic Velanovich

2009-01-01

Full Text Available An underlying assumption of quality of life outcome research is that after some intervention a “steady-state” of quality of life is reached which can be identified as an endpoint, and, hence, the “outcome.” However, in some disease processes, no so such steady-state is reached. The hypothesis presented is that a disease process with a waxing and waning course will make it difficult to determine a quality of life endpoint. After clinical observation, a pilot study of patients with either diabetic or idiopathic gastroparesis with gastric neurostimulation their records were reviewed to identify the number of clinic visits, the number of clinic visits in which the patients were asymptomatic, much improved, improved, no change, worse, or much worse. These changes were defined as “transitions.” A “transition ratio” was calculated by dividing the number of transitions by the number of clinic visits. Preliminary results showed that of 32 patients, the median number of clinic encounters was 8 (1–35, and the median number of transitions 4 (0–22. The average transition ration was 0.56±0.31. In the case of gastroparesis, over half of all clinical encounters were associated with a transition. The implication of the hypothesis and preliminary finding suggests a difficulty to identify when the symptomatic endpoint was reached. Other methods to assess the effects of treatment in such a disease process are required to fully understand the effects of treatment on quality of life.

Preliminary quantitative assessment of earthquake casualties and damages

DEFF Research Database (Denmark)

Badal, J.; Vázquez-Prada, M.; González, Á.

2005-01-01

Prognostic estimations of the expected number of killed or injured people and about the approximate cost associated with the damages caused by earthquakes are made following a suitable methodology of wide-ranging application. For the preliminary assessment of human life losses due to the occurrence...... of a relatively strong earthquake we use a quantitative model consisting of a correlation between the number of casualties and the earthquake magnitude as a function of population density. The macroseismic intensity field is determined in accordance with an updated anelastic attenuation law, and the number...... the local social wealth as a function of the gross domestic product of the country. This last step is performed on the basis of the relationship of the macroseismic intensity to the earthquake economic loss in percentage of the wealth. Such an approach to the human casualty and damage levels is carried out...

IMPACT OF A SERIOUS GAME FOR HEALTH ON CHRONIC DISEASE SELF-MANAGEMENT: PRELIMINARY EFFICACY AMONG COMMUNITY DWELLING ADULTS WITH HYPERTENSION.

Science.gov (United States)

Hickman, Ronald L; Clochesy, John M; Pinto, Melissa D; Burant, Christopher; Pignatiello, Grant

2015-01-01

Most Americans will acquire a chronic disease during their lifetime. One of the most prevalent chronic diseases that affect Americans is hypertension (HTN). Despite the known comorbidities and increased mortality rate associated with uncontrolled HTN, most community dwelling adults with HTN do not have sufficient blood pressure control Therefore, the aim of this article is to report the preliminary efficacy of a serious game for health to enhance blood pressure control among community dwelling adults with HTN. A nonprobability sample of 116 community dwelling adults with HTN participated in this nonblinded, randomized controlled trial. Participants were randomly assigned to: (1) an intervention arm that consisted of four exposures to a serious game for health known as eSMART-HD; or (2) an attentional control arm that compromised of four exposures to screen-based HTN education. The primary outcome measure for this trial was blood pressure reduction over a four month observational period. In this study, baseline characteristics and blood pressure measurements were similar between participants in each study arm. There was no significant between-group difference in blood pressure reduction over time. However, there were significant within-group reductions in systolic and diastolic blood pressures across time among favoring participants exposed to eSMART-HD. This study establishes the preliminary efficacy of eSMART-HD that can be easily administered to community dwelling adults and facilitate clinically significant reductions in systolic and diastolic blood pressures. Future studies should assess the influential components of this promising serious game for health (eSMART-HD) combined with medication management in larger and more diverse samples of community dwelling adults with HTN.

A new methodology for assessment of pectus excavatum correction after bar removal in Nuss procedure: Preliminary study.

Science.gov (United States)

Gomes-Fonseca, João; Vilaça, João L; Henriques-Coelho, Tiago; Direito-Santos, Bruno; Pinho, António C M; Fonseca, Jaime C; Correia-Pinto, Jorge

2017-07-01

The objective is to present a new methodology to assess quantitatively the impact of bar removal on the anterior chest wall, among patients with pectus excavatum who have undergone the Nuss procedure, and present a preliminary study using this methodology. We propose to acquire, for each patient, the surface of the anterior chest wall using a three-dimensional laser scanner at subsequent time points (short term: before and after surgery; long term: follow-up visit, 6months, and 12months after surgery). After surfaces postprocessing, the changes are assessed by overlapping and measuring the distances between surfaces. In this preliminary study, three time points were acquired and two assessments were performed: before vs after bar removal (early) and before vs 2-8weeks after bar removal (interim). In 21 patients, the signed distances and volumes between surfaces were computed and the data analysis was performed. This methodology revealed useful for monitoring changes in the anterior chest wall. On average, the mean, maximum, and volume variations, in the early assessment, were -0.1±0.1cm, -0.6±0.2cm, and 47.8±22.2cm 3 , respectively; and, in the interim assessment, were -0.5±0.2cm, -1.3±0.4cm, and 122.1±47.3cm 3 , respectively (pbar was in situ was inversely and significantly correlated with postretraction and was a relevant predictor of its decrease following surgery (pbar was in situ may be the main determinant of the anterior chest wall retraction following bar removal. Further studies should continue to corroborate and reinforce the preliminary findings, by increasing the sample size and performing long-term assessments. III. Copyright © 2017 Elsevier Inc. All rights reserved.

Preliminary assessment on compatibility of DUPIC fuel with CANDU-6

International Nuclear Information System (INIS)

Choi, Hang-Bok; Roh, G.H.; Jeong, C.J.; Rhee, B.W.; Choi, J.W.; Boss, C.R.

1997-01-01

The compatibility of DUPIC fuel with the existing CANDU-6 reactor was assessed. The technical issues of DUPIC fuel compatibility were chosen based on the CANDU physics design requirements and inherent characteristics of DUPIC fuel. The compatibility was assessed for the reference DUPIC fuel composition which was determined to reduce the composition heterogeneity and improve the spent PWR fuel utilization. Preliminary studies on a CANDU core loaded with DUPIC fuel have shown that the nominal power distribution is flatter than that of a natural uranium core when a 2-bundle shift refueling scheme is used, which reduces the reactivity worths of devices in the core and, therefore, the performance of reactivity devices was assessed. The safety of the core was assessed by a LOCA simulation and it was found that the power pulse upon LOCA can be maintained below that in the natural uranium core when a poison material is used in the DUPIC fuel. For the feasibility of handling DUPIC fuel in the plant, it will be necessary to introduce new equipment to load the DUPIC fuel in the refueling magazine. The radiation effect of DUPIC fuel on both the reactor hardware and the environment will be qualitatively analyzed later. (author)

Effects of sensitive electrical stimulation based cueing in Parkinson's disease: a preliminary study

Directory of Open Access Journals (Sweden)

Benoît Sijobert

2016-06-01

Full Text Available This study aims to investigate the effect of a sensitive cueing on Freezing of Gait (FOG and gait disorders in subjects suffering from Parkinson’s disease (PD. 13 participants with Parkinson’s disease were equipped with an electrical stimulator and a foot mounted inertial measurement unit (IMU. An IMU based algorithm triggered in real time an electrical stimulus applied on the arch of foot at heel off detection. Starting from standing, subjects were asked to walk at their preferred speed on a path comprising 5m straight, u-turn and walk around tasks. Cueing globally decreased the time to achieve the different tasks in all the subjects. In “freezer” subjects, the time to complete the entire path was reduced by 19%. FOG events occurrence was lowered by 12% compared to baseline before and after cueing. This preliminary work showed a positive global effect of an electrical stimulation based cueing on gait and FOG in PD.

Behavioural assessment of the dysexecutive syndrome (BADS in healthy elders and Alzheimer´s disease patients: preliminary study

Directory of Open Access Journals (Sweden)

Fabiola Canali

Full Text Available Abstract Although the main initial deficit is considered to be in the memory domain, an early impairment of executive functions is also found in AD where these deficits are correlated to functional impairment. Ecological tests are more indicated to evaluate executive impairment, and are better able to assist in treating AD patients than more commonly used tests. Objectives: The aim of this preliminary study is to verify the performance in executive functions using the Behavioural Assessment of the Dysexecutive Syndrome (BADS in elder controls and mild AD patients, and to analyze its applicability in our environment. Methods: The BADS was performed by 17 healthy elders and 17 early AD patients matched for age, schooling and gender. Results: There were significant differences among controls and AD patients on MMSE scores, and in measures of executive functions, memory, and motor speed. Some sub items of BADS (rule shift cards, modified six elements, total score, standard, standard by age and overall classification by age were also different between groups. Differences were also significant on the Dysexecutive Questionnaire (DEX of BADS self-ratings and other-ratings. Conclusion: BADS was efficacious in detecting executive deficits in this sample, as confirmed by other executive functions tests applied.

Norms for environmentally responsible behaviour: An extended taxonomy and a preliminary assessment

DEFF Research Database (Denmark)

Thøgersen, John

The currently used concept of personal or moral norms is ambiguous with regard to its motivational content. Therefore, a revision of the norm taxonomy is suggested, implying a distinction between three types of personal norms, called introjected, identified, and integrated norms. A preliminary as...... is also supported, with the reservation that the different behavioural references are more than just different methods of measuring the same latent construct(s). People evidently hold different norms for different environmentally responsible behaviours.......The currently used concept of personal or moral norms is ambiguous with regard to its motivational content. Therefore, a revision of the norm taxonomy is suggested, implying a distinction between three types of personal norms, called introjected, identified, and integrated norms. A preliminary...... assessment of the taxonomy is carried out based of a survey of a random sample of Danish residents 18 years or older. A range of norm constructs were measured with regard to four environmentally relevant behaviours: buying organic milk, buying energy saving light bulbs, source-separating compostable kitchen...

Assessing Internet addiction using the parsimonious Internet addiction components model - a preliminary study [forthcoming

OpenAIRE

Kuss, DJ; Shorter, GW; Van Rooij, AJ; Griffiths, MD; Schoenmakers, T

2014-01-01

Internet usage has grown exponentially over the last decade. Research indicates that excessive Internet use can lead to symptoms associated with addiction. To date, assessment of potential Internet addiction has varied regarding populations studied and instruments used, making reliable prevalence estimations difficult. To overcome the present problems a preliminary study was conducted testing a parsimonious Internet addiction components model based on Griffiths’ addiction components (2005), i...

Preliminary Marine Safety Risk Assessment, Brandon Road Lock and Dam Invasive Species Control Measures

Science.gov (United States)

2016-12-01

Decision makers must include control-measure monitoring and emergency “interventions” to insure safety. The Coast Guard operational commanders...system” incorporates a travelling car on a rail above the barge-loading wharf to prevent loading personnel, cargo surveyors, or others from falling...to the Gulf of Mexico . As “Loopers”, they will have already transited the CSSC electric barriers. Preliminary Marine Safety Risk Assessment, BRLD

Image registration for assessment of Crohn's disease severity

NARCIS (Netherlands)

Li, Z.

2015-01-01

Crohn’s disease (CD) is a chronic inflammatory bowel disease (IBD) that affects millions of people in Europe alone. It is important to accurately assess the disease severity in a safe and non-invasive manner in order to improve the treatment of patients with CD. Furthermore, the ideal assessment

Preliminary assessment of adjuster system performance in CANDU-6 RUFIC core

International Nuclear Information System (INIS)

Kim, Soon Young; Suk, Ho Chun

2002-07-01

Four operational transients in CANDU-6 RUFIC core have been simulated to assess the adjuster system performance. These transients included startup after a short shutdown, startup after a poison-out shutdown, shim mode operation, and a stepback to 60% full power. Also, an alternative adjuster-banking scheme has been assessed in this report. The alternative adjuster-banking scheme involves rods in Bank 1 and Bank 7 being re-distributed within the two banks. In the alternative adjuster-banking scheme, Bank 1 becomes the heaviest one. The results of the preliminary assessment indicated that the adjuster system as currently designed and installed in the NU core will adequately meet the functional requirements in the RUFIC core. Comparing to the adjuster system performance in the NU core, the total worth of the adjuster in the RUFIC core is reduced, leading to less xenon override capability and shimming capability. However, the overall performance is expected to still be satisfactory. The overall results from the transient studied indicated that the alternative banking scheme does show some better performance characteristics and merits further detailed studies

Super-Efficient Refrigerator Program (SERP) evaluation volume 2: Preliminary impact and market transformation assessment

Energy Technology Data Exchange (ETDEWEB)

Lee, A.D.; Conger, R.L.

1996-08-01

The Super Efficient Refrigerator Program (SERP) is a collaborative utility program intended to transform the market for energy-efficient and environmentally friendly refrigerators. It is one of the first examples of a large-scale {open_quotes}market transformation{close_quotes} energy efficiency program. This report documents the preliminary impact and market transformation evaluation of SERP ({open_quotes}the Program{close_quotes}). Pacific Northwest National Laboratory (PNNL) conducted this evaluation for the U.S. Department of Energy. This study focuses on the preliminary impact evaluation and market transformation assessment, but also presents limited process evaluation information. It is based on interviews with refrigerator dealers and manufacturers, interviews with utility participants, industry data, and information from the Program administrators. Results from this study complement those from prior process evaluation also conducted by PNNL. 42 refs., 5 figs., 4 tabs.

The costs of failure: A preliminary assessment of major energy accidents, 1907-2007

International Nuclear Information System (INIS)

Sovacool, Benjamin K.

2008-01-01

A combination of technical complexity, tight coupling, speed, and human fallibility contribute to the unexpected failure of large-scale energy technologies. This study offers a preliminary assessment of the social and economic costs of major energy accidents from 1907 to 2007. It documents 279 incidents that have been responsible for $41 billion in property damage and 182,156 deaths. Such disasters highlight an often-ignored negative externality to energy production and use, and emphasize the need for further research

Development of the Music Therapy Assessment Tool for Advanced Huntington's Disease: A Pilot Validation Study.

Science.gov (United States)

O'Kelly, Julian; Bodak, Rebeka

2016-01-01

Case studies of people with Huntington's disease (HD) report that music therapy provides a range of benefits that may improve quality of life; however, no robust music therapy assessment tools exist for this population. Develop and conduct preliminary psychometric testing of a music therapy assessment tool for patients with advanced HD. First, we established content and face validity of the Music Therapy Assessment Tool for Advanced HD (MATA-HD) through focus groups and field testing. Second, we examined psychometric properties of the resulting MATA-HD in terms of its construct validity, internal consistency, and inter-rater and intra-rater reliability over 10 group music therapy sessions with 19 patients. The resulting MATA-HD included a total of 15 items across six subscales (Arousal/Attention, Physical Presentation, Communication, Musical, Cognition, and Psychological/Behavioral). We found good construct validity (r ≥ 0.7) for Mood, Communication Level, Communication Effectiveness, Choice, Social Behavior, Arousal, and Attention items. Cronbach's α of 0.825 indicated good internal consistency across 11 items with a common focus of engagement in therapy. The inter-rater reliability (IRR) Intra-Class Coefficient (ICC) scores averaged 0.65, and a mean intra-rater ICC reliability of 0.68 was obtained. Further training and retesting provided a mean of IRR ICC of 0.7. Preliminary data indicate that the MATA-HD is a promising tool for measuring patient responses to music therapy interventions across psychological, physical, social, and communication domains of functioning in patients with advanced HD. © the American Music Therapy Association 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Preliminary assessment report for Army Aviation Support Facility No. 3, Installation 13307, Hunter Army Airfield, Savannah, Georgia

International Nuclear Information System (INIS)

Kolpa, R.; Smith, K.

1993-07-01

This report presents the results of the preliminary assessment (PA) conducted by Argonne National Laboratory at the Georgia Army National Guard property located on Hunter Army Airfield (HAA) near Savannah, Georgia, known as Army Aviation Support Facility (AASF) No. 3. Preliminary assessments of federal facilities are being conducted to compile the information necessary for completing preremedial activities and to provide a basis for establishing corrective actions in response to releases of hazardous substances. The principal objective of the PA is to characterize the site accurately and determine the need for further action by examining site activities, types and quantities of hazardous substances utilized, the nature and amounts of wastes generated or stored at the facility, and potential pathways by which contamination could affect public health and the environment. This PA satisfies, for the AASF No. 3 property, requirements of the Department of Defense Installation Restoration Program (IRP). The scope of this assessment is limited to the facilities and past activities contained within the area now occupied by AASF No. 3. However, this assessment report is intended to be read in conjunction with a previous IRP assessment of HAA completed in 1992 (USATHAMA 1992) and to provide comprehensive information on AASF No. 3 for incorporation with information contained in that previous assessment for the entirety of HAA

Preliminary assessment of PWR Steam Generator modelling in RELAP5/MOD3

International Nuclear Information System (INIS)

Preece, R.J.; Putney, J.M.

1993-07-01

A preliminary assessment of Steam Generator (SG) modelling in the PWR thermal-hydraulic code RELAP5/MOD3 is presented. The study is based on calculations against a series of steady-state commissioning tests carried out on the Wolf Creek PWR over a range of load conditions. Data from the tests are used to assess the modelling of primary to secondary side heat transfer and, in particular, to examine the effect of reverting to the standard form of the Chen heat transfer correlation in place of the modified form applied in RELAP5/MOD2. Comparisons between the two versions of the code are also used to show how the new interphase drag model in RELAP5/MOD3 affects the calculation of SG liquid inventory and the void fraction profile in the riser

The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis.

LENUS (Irish Health Repository)

Keen, H I

2008-05-01

Painful osteoarthritis (OA) of the hand is common and a validated ultrasound (US) scoring system would be valuable for epidemiological and therapeutic outcome studies. US is increasingly used to assess peripheral joints, though most of the US focus in rheumatic diseases has been on rheumatoid arthritis. We aimed to develop a preliminary US hand OA scoring system, initially focusing on relevant pathological features with potentially high reliability.

Diffusion-weighted imaging in assessing renal pathology of chronic kidney disease: A preliminary clinical study

Energy Technology Data Exchange (ETDEWEB)

Li, Qinghai; Li, Jinning; Zhang, Lan; Chen, Ying; Zhang, Minming [Department of Radiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009 (China); Yan, Fuhua, E-mail: zemylife@163.com [Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025 (China)

2014-05-15

Objective: To investigate the clinical potential of diffusion-weighted imaging (DWI) in assessing renal pathology of chronic kidney disease (CKD). Methods: Seventy-one CKD patients and twelve healthy volunteers were examined using DWI with prospective acquisition correction. Renal biopsy specimens from the CKD patients were scored based on the severity of renal pathology and to confirm pathology type. CKD patients were divided into three groups according to pathology scores: mild, moderate, or severe. The association between renal apparent diffusion coefficient (ADC) values and pathology scores was investigated using Pearson's correlation and single factor analysis of variance. Multiple linear regression analysis was performed to explore associations between renal ADC values and pathology score, glomerular filtration rate, serum creatinine, and age. The Kruskal–Wallis H test was conducted to compare ADC values and pathology type. Results: Renal ADC values correlated negatively with pathology scores (r = −0.633, P < 0.001). The ADC values among the four groups (mild, moderate, severe impairment, and controls) were significantly different (F = 19.512, P < 0.001). However, when patients were stratified by pathology type, no significant differences were found in ADC values among these groups (χ{sup 2} = 9.929, P = 0.270). Further multiple linear regression analysis showed that only the pathology score and ADC values were related (t = −4.586, P = 0.000). Conclusions: DWI has clinical potential in assessing the severity of renal pathology in CKD and shows promise as a non-invasive and effective technique to guide therapy and follow-up.

Diffusion-weighted imaging in assessing renal pathology of chronic kidney disease: A preliminary clinical study

International Nuclear Information System (INIS)

Li, Qinghai; Li, Jinning; Zhang, Lan; Chen, Ying; Zhang, Minming; Yan, Fuhua

2014-01-01

Objective: To investigate the clinical potential of diffusion-weighted imaging (DWI) in assessing renal pathology of chronic kidney disease (CKD). Methods: Seventy-one CKD patients and twelve healthy volunteers were examined using DWI with prospective acquisition correction. Renal biopsy specimens from the CKD patients were scored based on the severity of renal pathology and to confirm pathology type. CKD patients were divided into three groups according to pathology scores: mild, moderate, or severe. The association between renal apparent diffusion coefficient (ADC) values and pathology scores was investigated using Pearson's correlation and single factor analysis of variance. Multiple linear regression analysis was performed to explore associations between renal ADC values and pathology score, glomerular filtration rate, serum creatinine, and age. The Kruskal–Wallis H test was conducted to compare ADC values and pathology type. Results: Renal ADC values correlated negatively with pathology scores (r = −0.633, P < 0.001). The ADC values among the four groups (mild, moderate, severe impairment, and controls) were significantly different (F = 19.512, P < 0.001). However, when patients were stratified by pathology type, no significant differences were found in ADC values among these groups (χ 2 = 9.929, P = 0.270). Further multiple linear regression analysis showed that only the pathology score and ADC values were related (t = −4.586, P = 0.000). Conclusions: DWI has clinical potential in assessing the severity of renal pathology in CKD and shows promise as a non-invasive and effective technique to guide therapy and follow-up

Preliminary nuclear power reactor technology qualitative assessment for Malaysia

International Nuclear Information System (INIS)

Shamsul Amri Sulaiman

2011-01-01

Since the worlds first nuclear reactor major breakthrough in December 02, 1942, the nuclear power industry has undergone tremendous development and evolution for more than half a century. After surpassing moratorium of nuclear power plant construction caused by catastrophic accidents at Three-mile island (1979) and Chernobyl (1986), today, nuclear energy is back on the policy agendas of many countries, both developed and developing, signaling nuclear revival or nuclear renaissance. Selection of suitable nuclear power technology has thus been subjected to primary attention. This short paper attempts to draw preliminary technology assessment for the first nuclear power reactor technology for Malaysia. Methodology employed is qualitative analysis collating recent finding of tnb-kepco preliminary feasibility study for nuclear power program in peninsular malaysia and other published presentations and/or papers by multiple experts. The results suggested that pressurized water reactor (PWR) is the prevailing technology in terms of numbers and plant performances, and while the commercialization of generation IV reactors is remote (e.g. Not until 2030), generation III/ III+ NPP models are commercially available on the market today. Five (5) major steps involved in reactor technology selection were introduced with a focus on introducing important aspects of selection criteria. Three (3) categories for the of reactor technology selection were used for the cursory evaluation. The outcome of these analyses shall lead to deeper and full analyses of the recommended reactor technologies for a comprehensive feasibility study in the near future. Recommendations for reactor technology option were also provided for both strategic and technical recommendations. The paper shall also implore the best way to select systematically the first civilian nuclear power reactor. (Author)

Preliminary Risk Assessment of the Southwestern Willow Flycatcher (Empidonax traillii extimus) at the Los Alamos National Laboratory

Energy Technology Data Exchange (ETDEWEB)

Gallegos, A.F.; Gonzales, G.J.; Bennett, K.D.; Mullen, M.A.; Foxx, T.S.

1998-10-01

The southwestern willow flycatcher (Empidonax traillii extimus) is the fourth threatened or endangered species to undergo a preliminary assessment for estimating potential risk from environmental contaminants at the Los Alamos National Laboratory. The assessments are being conducted as part of a three-year project to develop a habitat management plan for threatened and endangered species and species of concern at the Laboratory. For the preliminary assessment, estimated doses were compared against toxicity reference values to generate hazard indices (HIs). This assessment included a measure of cumulative effects from multiple contaminants (radionuclides, metals, and organic chemicals) to 100 simulated nest sites located within flycatcher potential habitat. Sources of contaminant values were 10,000-ft{sup 2} grid cells within an Ecological Exposure Unit (EEU). This EEU was estimated around the potential habitat and was based on the maximum home range for the fly catcher identified in the scientific literature. The tools used included a custom FORTRAN program, ECORSK5, and a geographic information system. Food consumption and soil ingestion contaminant pathways were addressed in the assessment. Using a four-category risk evaluation, HI results indicate no appreciable impact is expected to the southwestern willow flycatcher. Information on risk by specific geographical location was generated, which can be used to manage contaminated areas, flycatcher habitat, facility siting, and/or facility operations in order to maintain low levels of risk from contaminants.

Preliminary Risk Assessment of the Southwestern Willow Flycatcher (Empidonax traillii extimus) at the Los Alamos National Laboratory

International Nuclear Information System (INIS)

Gallegos, A.F.; Gonzales, G.J.; Bennett, K.D.; Mullen, M.A.; Foxx, T.S.

1998-01-01

The southwestern willow flycatcher (Empidonax traillii extimus) is the fourth threatened or endangered species to undergo a preliminary assessment for estimating potential risk from environmental contaminants at the Los Alamos National Laboratory. The assessments are being conducted as part of a three-year project to develop a habitat management plan for threatened and endangered species and species of concern at the Laboratory. For the preliminary assessment, estimated doses were compared against toxicity reference values to generate hazard indices (HIs). This assessment included a measure of cumulative effects from multiple contaminants (radionuclides, metals, and organic chemicals) to 100 simulated nest sites located within flycatcher potential habitat. Sources of contaminant values were 10,000-ft 2 grid cells within an Ecological Exposure Unit (EEU). This EEU was estimated around the potential habitat and was based on the maximum home range for the fly catcher identified in the scientific literature. The tools used included a custom FORTRAN program, ECORSK5, and a geographic information system. Food consumption and soil ingestion contaminant pathways were addressed in the assessment. Using a four-category risk evaluation, HI results indicate no appreciable impact is expected to the southwestern willow flycatcher. Information on risk by specific geographical location was generated, which can be used to manage contaminated areas, flycatcher habitat, facility siting, and/or facility operations in order to maintain low levels of risk from contaminants

Screening for Peripheral Artery Disease and Cardiovascular Disease Risk Assessment with Ankle Brachial Index in Adults

Science.gov (United States)

... Force Recommendations Screening for Peripheral Artery Disease and Cardiovascular Disease Risk Assessment with Ankle Brachial Index in Adults ... on Screening for Peripheral Artery Disease (PAD) and Cardiovascular Disease (CVD) Risk Assessment with Ankle Brachial Index (ABI) ...

Wind power in Eritrea, Africa: A preliminary resource assessment

Energy Technology Data Exchange (ETDEWEB)

Garbesi, K.; Rosen, K. [San Jose State Univ., CA (United States); Van Buskirk, R. [Dept. of Energy, Eritrea (Ethiopia)

1997-12-31

The authors preliminary assessment of Eritrean wind energy potential identified two promising regions: (1) the southeastern Red Sea coast and (2) the mountain passes that channel winds between the coastal lowlands and the interior highlands. The coastal site, near the port city of Aseb, has an exceptionally good resource, with estimated average annual wind speeds at 10-m height above 9 m/s at the airport and 7 m/s in the port. Furthermore, the southern 200 km of coastline has offshore WS{sub aa} > 6 m/s. This area has strong potential for development, having a local 20 MW grid and unmet demand for the fishing industry and development. Although the highland sites contain only marginal wind resources ({approximately} 5 m/s), they warrant further investigation because of their proximity to the capital city, Asmera, which has the largest unmet demand and a larger power grid (40 MW with an additional 80 MW planned) to absorb an intermittent source without storage.

A preliminary assessment of the Titan planetary boundary layer

Science.gov (United States)

Allison, Michael

1992-01-01

Results of a preliminary assessment of the characteristic features of the Titan planetary boundary are addressed. These were derived from the combined application of a patched Ekman surface layer model and Rossby number similarity theory. Both these models together with Obukhov scaling, surface speed limits and saltation are discussed. A characteristic Akman depth of approximately 0.7 km is anticipated, with an eddy viscosity approximately equal to 1000 sq cm/s, an associated friction velocity approximately 0.01 m/s, and a surface wind typically smaller than 0.6 m/s. Actual values of these parameters probably vary by as much as a factor of two or three, in response to local temporal variations in surface roughness and stability. The saltation threshold for the windblown injection of approximately 50 micrometer particulates into the atmosphere is less than twice the nominal friction velocity, suggesting that dusty breezes might be an occassional feature of the Titan meteorology.

Site Characterization and Preliminary Performance Assessment Calculation Applied To JAEA-Horonobe URL Site of Japan

International Nuclear Information System (INIS)

Lim, Doo Hyun; Hatanaka, Koichiro; Ishii, Eiichi

2010-01-01

JAEA-Horonobe Underground Research Laboratory (URL) is designed for research and development on high-level radioactive waste (HLW) repository in sedimentary rock. For a potential HLW repository, understanding and implementing fracturing and faulting system, with data from the site characterization, into the performance assessment is essential because fracture and fault will be the major conductors or barriers for the groundwater flow and radionuclide release. The objectives are i) quantitative derivation of characteristics and correlation of fracturing/faulting system with geologic and geophysics data obtained from the site characterization, and ii) preliminary performance assessment calculation with characterized site information

Site Characterization and Preliminary Performance Assessment Calculation Applied To JAEA-Horonobe URL Site of Japan

Energy Technology Data Exchange (ETDEWEB)

Lim, Doo Hyun [NE Union Hill Road, Suite 200, WA 98052 (United States); Hatanaka, Koichiro; Ishii, Eiichi [Japan Atomic Energy Agency, Hokkaido (Japan)

2010-10-15

JAEA-Horonobe Underground Research Laboratory (URL) is designed for research and development on high-level radioactive waste (HLW) repository in sedimentary rock. For a potential HLW repository, understanding and implementing fracturing and faulting system, with data from the site characterization, into the performance assessment is essential because fracture and fault will be the major conductors or barriers for the groundwater flow and radionuclide release. The objectives are i) quantitative derivation of characteristics and correlation of fracturing/faulting system with geologic and geophysics data obtained from the site characterization, and ii) preliminary performance assessment calculation with characterized site information

A Delphic consensus assessment: imaging and biomarkers in gastroenteropancreatic neuroendocrine tumor disease management

Directory of Open Access Journals (Sweden)

Kjell Oberg

2016-09-01

Full Text Available The complexity of the clinical management of neuroendocrine neoplasia (NEN is exacerbated by limitations in imaging modalities and a paucity of clinically useful biomarkers. Limitations in currently available imaging modalities reflect difficulties in measuring an intrinsically indolent disease, resolution inadequacies and inter-/intra-facility device variability and that RECIST (Response Evaluation Criteria in Solid Tumors criteria are not optimal for NEN. Limitations of currently used biomarkers are that they are secretory biomarkers (chromogranin A, serotonin, neuron-specific enolase and pancreastatin; monoanalyte measurements; and lack sensitivity, specificity and predictive capacity. None of them meet the NIH metrics for clinical usage. A multinational, multidisciplinary Delphi consensus meeting of NEN experts (n = 33 assessed current imaging strategies and biomarkers in NEN management. Consensus (>75% was achieved for 78% of the 142 questions. The panel concluded that morphological imaging has a diagnostic value. However, both imaging and current single-analyte biomarkers exhibit substantial limitations in measuring the disease status and predicting the therapeutic efficacy. RECIST remains suboptimal as a metric. A critical unmet need is the development of a clinico-biological tool to provide enhanced information regarding precise disease status and treatment response. The group considered that circulating RNA was better than current general NEN biomarkers and preliminary clinical data were considered promising. It was resolved that circulating multianalyte mRNA (NETest had clinical utility in both diagnosis and monitoring disease status and therapeutic efficacy. Overall, it was concluded that a combination of tumor spatial and functional imaging with circulating transcripts (mRNA would represent the future strategy for real-time monitoring of disease progress and therapeutic efficacy.

A preliminary strategic environmental impact assessment of mineral and hydrocarbon activities on the Nuussuaq peninsula, West Greenland

Energy Technology Data Exchange (ETDEWEB)

Boertmann, D.; Asmund, G.; Glahder, C.; Tamstorf, M.

2008-01-15

There is an increasing interest for mineral and hydrocarbon exploration in Greenland and in both regards the Nuussuaq peninsula is in focus. This preliminary strategic environmental impact assessment describes the status of the biological knowledge from the area and designates potential conflicts between activities and the biological environment. Furthermore biological knowledge gaps are identified. These should be filled before specific environmental impacts assessments can be carried out and relevant studies to fill these data gaps are proposed. (au)

Preliminary assessment report for Grubbs/Kyle Training Center, Smyrna/Rutherford County Regional Airport, Installation 47340, Smyrna, Tennessee. Installation Restoration Program

Energy Technology Data Exchange (ETDEWEB)

Dennis, C.; Stefano, J.

1993-07-01

This report presents the results of the preliminary assessment (PA) conducted by Argonne National Laboratory at the Tennessee Army National Guard (TNARNG) property near Smyrna, Tennessee. Preliminary assessments of federal facilities are being conducted to compile the information necessary for completing preremedial activities and to provide a basis for establishing corrective actions in response to releases of hazardous substances. The principal objective of the PA is to characterize the site accurately and determine the need for further action by examining site activities, quantities of hazardous substances present, and potential pathways by which contamination could affect public health and the environment. This PA satisfies, for the Grubbs/Kyle Training Center property, the requirement of the Department of Defense Installation Restoration Program.

UVISS preliminary visibility analysis

DEFF Research Database (Denmark)

Betto, Maurizio

1998-01-01

The goal of this work is to obtain a preliminary assessment of the sky visibility for anastronomical telescope located on the express pallet of the International SpaceStation (ISS)} taking into account the major constraints imposed on the instrument by the ISSattitude and structure. Part of the w......The goal of this work is to obtain a preliminary assessment of the sky visibility for anastronomical telescope located on the express pallet of the International SpaceStation (ISS)} taking into account the major constraints imposed on the instrument by the ISSattitude and structure. Part...... of the work is also to setup the kernel of a software tool for the visibility analysis thatshould be easily expandable to consider more complex strucures for future activities.This analysis is part of the UVISS assessment study and it is meant to provide elementsfor the definition and the selection...

Preliminary assessment of the possibility of supporting the decomposition of biodegradable packaging

Directory of Open Access Journals (Sweden)

Niekraś Lidia

2017-01-01

Full Text Available This article presents a preliminary evaluation of the possibility of using grass biomass from a sports field as a compost ingredient which positively affects the degree of decomposition of the biodegradable wrappings. For 5 months the biodegradable bags were stored, both empty and filled with organic waste in the heap of grass clippings. After that period, fragments of the bags were observed under the microscope and then assessed the state of their decomposition. The results indicate that the biomass used favourably affected the process of bag degradation, however the speed of decomposition of the empty bags was quicker than the bags filled with the organic waste.

Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease.

Science.gov (United States)

Hussein, Norita; Weng, Stephen F; Kai, Joe; Kleijnen, Jos; Qureshi, Nadeem

2018-03-14

Globally, about five per cent of children are born with congenital or genetic disorders. The most common autosomal recessive conditions are thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease, with higher carrier rates in specific patient populations. Identifying and counselling couples at genetic risk of the conditions before pregnancy enables them to make fully informed reproductive decisions, with some of these choices not being available if genetic counselling is only offered in an antenatal setting. This is an update of a previously published review. To assess the effectiveness of systematic preconception genetic risk assessment to improve reproductive outcomes in women and their partners who are identified as carriers of thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease in healthcare settings when compared to usual care. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group's Trials Registers. In addition, we searched for all relevant trials from 1970 (or the date at which the database was first available if after 1970) to date using electronic databases (MEDLINE, Embase, CINAHL, PsycINFO), clinical trial databases (National Institutes of Health, Clinical Trials Search portal of the World Health Organization, metaRegister of controlled clinical trials), and hand searching of key journals and conference abstract books from 1998 to date (European Journal of Human Genetics, Genetics in Medicine, Journal of Community Genetics). We also searched the reference lists of relevant articles, reviews and guidelines and also contacted subject experts in the field to request any unpublished or other published trials.Date of latest search of the registers: 20 June 2017.Date of latest search of all other sources: 16 November 2017. Any randomised or quasi-randomised controlled trials (published or unpublished) comparing reproductive outcomes of systematic preconception genetic risk assessment for thalassaemia, sickle

Assessment of adrenal function in liver diseases

Directory of Open Access Journals (Sweden)

Sandeep Kharb

2013-01-01

Full Text Available Background: In recent times, there are reports of adrenal dysfunction in whole spectrum of liver disease. Adrenal insufficiency (AI has been shown to correlate with progression of liver disease. Hence this study was conducted to assess adrenal function in subjects with acute liver disease (ALD, chronic liver disease (CLD and post liver transplantation (LT. Material and Methods: This study included 25 healthy controls, 25 patients of ALD, 20 subjects of CLD with Child-Pugh stage A (CLD-1 and 30 with Child-Pugh stage B or C (CLD-2, and 10 subjects with LT. All subjects were assessed clinically, biochemically and for adrenal functions. Results: AI was present in 9 (34.6% patients with ALD, 20 (40% patients with CLD and 4 (40% in subjects with LT. AI was more common in CLD-2 (18 patients - 60% than CLD-1 (2 patients - 10%. All patients with chronic liver disease had significantly lower basal cortisol (8.8±4.8, P=0.01, stimulated cortisol (18.2±6.3, P <0.00001 and incremental cortisol (9.4±4.6, P <0.00001 as compared to controls. There was increase in percentage of subjects with adrenal dysfunction with progression of liver disease as assessed by Child-Pugh staging. AI was predicted by lower levels of serum protein, serum albumin, total cholesterol and HDL cholesterol and higher levels of serum bilirubin and INR. Adrenal functions showed recovery following liver transplantation. Conclusions: AI forms important part of spectrum of acute and chronic liver disease. Deterioration of synthetic functions of liver disease predicts presence of AI, and these patients should be evaluated for adrenal dysfunction periodically.

Preliminary safety assessment study for the conceptual design of a repository in tuff at Yucca Mountain

International Nuclear Information System (INIS)

Jackson, J.L.; Gram, H.F.; Hong, K.J.; Ng, H.S.; Pendergrass, A.M.

1984-12-01

Preliminary estimates of the upper bounds on postulated worst-case radiological releases resulting from possible accidents during the operating period of a prospective repository in tuff at Yucca Mountain are presented. Possible disrupting events are screened to identify the accidents of greatest potential consequence. The radiological dose commitments for the general public and repository personnel are estimated for postulated releases caused by natural phenomena, man-made events, and operational accidents. All postulated worst-case releases result in doses to the public that are lower than the 0.5-rem, whole-body dose-per-accident limit set by the Nuclear Regulatory Commission (NRC) in 10 CFR 60. Doses to repository personnel are within the NRC's 5.0-rem/yr occupational exposure limit set in 10 CFR 20 for normal operations. Doses are within this limit for all accidents except the transportation accident and fire in a drift. A preliminary risk assessment has also been performed. Based on this preliminary safety study, the proposed site boundaries and design criteria routinely used in constructing nuclear facilities appear to be adequate to protect the safety of the general public during the operating phase of the repository

[Assessment of invalidity as a result of infectious diseases].

Science.gov (United States)

Čeledová, L; Čevela, R; Bosák, M

2016-01-01

The article features the new medical assessment paradigm for invalidity as a result of infectious disease which is applied as of 1 January 2010. The invalidity assessment criteria are regulated specifically by Regulation No. 359/2009. Chapter I of the Annexe to the invalidity assessment regulation addresses the area of infectious diseases with respect to functional impairment and its impact on the quality of life. Since 2010, the invalidity has also been newly categorized into three groups. The new assessment approach makes it possible to evaluate a persons functional capacity, type of disability, and eligibility for compensation for reduced capacity for work. In 2010, a total of 170 375 invalidity cases were assessed, and in 2014, 147 121 invalidity assessments were made. Invalidity as a result of infectious disease was assessed in 177 persons in 2010, and 128 invalidity assessments were made in 2014. The most common causes of invalidity as a result of infectious disease are chronic viral hepatitis, other spirochetal infections, tuberculosis of the respiratory tract, tick-borne viral encephalitis, and HIV/AIDS. The number of assessments of invalidity as a result of infectious disease showed a declining trend between 2010 and 2014, similarly to the total of invalidity assessments. In spite of this fact, the cases of invalidity as a result of infectious disease account for approximately half percent of all invalidity assessments made in the above-mentioned period of time.

Preliminary post-closure safety assessment of repository concepts for low level radioactive waste at the Bruce Site, Ontario

International Nuclear Information System (INIS)

Little, R.H.; Penfold, J.S.S.; Egan, M.J.; Leung, H.

2005-01-01

The preliminary post-closure safety assessment of permanent repository concepts for low-level radioactive waste (LLW) at the Ontario Power Generation (OPG) Bruce Site is described. The study considered the disposal of both short and long-lived LLW. Four geotechnically feasible repository concepts were considered (two near-surface and two deep repositories). An approach consistent with best international practice was used to provide a reasoned and comprehensive analysis of post-closure impacts of the repository concepts. The results demonstrated that the deep repository concepts in shale and in limestone, and the surface repository concept on sand should meet radiological protection criteria. For the surface repository concept on glacial till, it appears that increased engineering such as grouting of waste and voids should be considered to meet the relevant dose constraint. Should the project to develop a permanent repository for LLW proceed, it is expected that this preliminary safety assessment would need to be updated to take account of future site-specific investigations and design updates. (author)

Development of the music therapy assessment Tool for advanced Huntington’s disease: A pilot validation study

DEFF Research Database (Denmark)

O'Kelly, Julian; Bodak, Rebeka

2016-01-01

Background: Case studies of people with Huntington's disease (HD) report that music therapy provides a range of benefits that may improve quality of life; however, no robust music therapy assessment tools exist for this population. Objective: Develop and conduct preliminary psychometric testing...... of its construct validity, internal consistency, and inter-rater and intra-rater reliability over 10 group music therapy sessions with 19 patients. Results: The resulting MATA-HD included a total of 15 items across six subscales (Arousal/Attention, Physical Presentation, Communication, Musical, Cognition......, and Psychological/Behavioral). We found good construct validity (r ≥ 0.7) for Mood, Communication Level, Communication Effectiveness, Choice, Social Behavior, Arousal, and Attention items. Cronbach's α of 0.825 indicated good internal consistency across 11 items with a common focus of engagement in therapy...

A preliminary disease survey in the wild Nile crocodile (Crocodylus niloticus population in the Okavango Delta, Botswana

Directory of Open Access Journals (Sweden)

A. J. Leslie

2011-04-01

Full Text Available The objective of this study was to conduct a preliminary survey of diseases that might be present in the wild Nile crocodile population in the Okavango Delta, Botswana. Blood samples were collected from crocodiles ranging in size from 34.0cmto 463.0cmtotal length. Samples were examined for blood parasites and underwent a haematological analysis. Before release the crocodiles were examined for various clinical abnormalities. Of the 144 crocodiles examined, none were visibly sick or displayed any signs of disease. No antibodies to Mycoplasma crocodyli were detected. Hepatozoon pettiti was present in 55.3 % of blood smears examined, but there was no significant difference in any of the haematological values between the infected and uninfected crocodiles, and a high prevalence of Hepatozoon infection is not uncommon in other species. Only 7.6 % of the examined crocodiles were infested with leeches. Further research is required for several of the crocodilian diseases, in particular to elucidate the role of wild crocodilians as reservoirs of infection.

Non-invasive brain stimulation to assess and modulate neuroplasticity in Alzheimer's disease.

Science.gov (United States)

Boggio, Paulo Sérgio; Valasek, Claudia Aparecida; Campanhã, Camila; Giglio, Ana Carolina Alem; Baptista, Nathalia Ishikawa; Lapenta, Olivia Morgan; Fregni, Felipe

2011-10-01

Alzheimer's disease (AD) is a neurodegenerative and progressive disease related to a gradual decline in cognitive functions such as memory, attention, perceptual-spatial abilities, language, and executive functions. Recent evidence has suggested that interventions promoting neural plasticity can induce significant cognitive gains especially in subjects at risk of or with mild AD. Transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) are non-invasive techniques that can induce significant and long-lasting changes in focal and non-focal neuroplasticity. In this review, we present initial preliminary evidence that TMS and tDCS can enhance performance in cognitive functions typically impaired in AD. Also, we reviewed the initial six studies on AD that presented early findings showing cognitive gains such as in recognition memory and language associated with TMS and tDCS treatment. In addition, we showed that TMS has also been used to assess neuroplasticity changes in AD supporting the notion that cortical excitability is changed in AD due to the neurodegenerative process. Due to the safe profile, cost of these tools, and initial clinical trials results, further studies are warranted in order to replicate and extend the initial findings of rTMS and tDCS as cognitive enhancers in AD. Further trials should explore different targets of stimulation along with different paradigms of stimulation including combination with behavioural interventions.

Preliminary performance assessment for the Waste Isolation Pilot Plant, December 1992

International Nuclear Information System (INIS)

1992-12-01

Before disposing of transuranic radioactive waste in the Waste Isolation Pilot Plant (WIPP), the United States Department of Energy (DOE) must evaluate compliance with applicable long-term regulations of the United States Environmental Protection Agency (EPA). Sandia National Laboratories is conducting iterative performance assessments (PAs) of the WIPP for the DOE to provide interim guidance while preparing for a final compliance evaluation. This volume, Volume 2, contains the technical basis for the 1992 PA. Specifically, it describes the conceptual basis for consequence modeling and the PA methodology, including the selection of scenarios for analysis, the determination of scenario probabilities, and the estimation of scenario consequences using a Monte Carlo technique and a linked system of computational models. Additional information about the 1992 PA is provided in other volumes. Volume I contains an overview of WIPP PA and results of a preliminary comparison with the long-term requirements of the EPA's Environmental Protection Standards for Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes (40 CFR 191, Subpart B). Volume 3 contains the reference data base and values for input parameters used in consequence and probability modeling. Volume 4 contains uncertainty and sensitivity analyses related to the preliminary comparison with 40 CFR 191B. Volume 5 contains uncertainty and sensitivity analyses of gas and brine migration for undisturbed performance. Finally, guidance derived from the entire 1992 PA is presented in Volume 6

System of tactical assessment in Soccer (FUT-SAT: Development and preliminary validation

Directory of Open Access Journals (Sweden)

I.T. Costa

2011-01-01

Full Text Available The purpose of this paper was to report the development and preliminary validation of tactical assessment system in Soccer and highlight its advantages. The validation process followed five perspectives of the concept of validity that consider the value of heuristic methods and the importance of the description of behavior performed in playing situations. Thus, the process of validation was focused on four points: i acceptability and reasonableness of the test perceived by players; ii analysis of content of assessment tool through a panel of experts; iii potential of the assessment tool to discriminate the quality of the performance of players; iv observation reliability. The results displayed values higher than 0.63 for correlation between the evaluations of coaches and the system. It shows the potential of this system to distinguish the performances of players based on the evaluations of coaches. The players who performed the field test agreed with its physical demands and spatial and normative configurations. All experts endorsed the categories and variables of this system. The reliabilities showed values higher than 0.79 for intra and inter-observers. Therefore, it is possible to conclude that the system is valid and reliable for the assessment of the tactical behavior of soccer players.

Preliminary Assessment of Potential Avian Interactions at Four Proposed Wind Energy Facilities on Vandenberg Air Force Base, California

Energy Technology Data Exchange (ETDEWEB)

2004-08-01

The United States Air Force (USAF) is investigating whether to install wind turbines to provide a supplemental source of electricity at Vandenberg Air Force Base (VAFB) near Lompoc, California. As part of that investigation, VAFB sought assistance from the U.S. Department of Energy's National Renewable Energy Laboratory (NREL) to provide a preliminary characterization of the potential risk to wildlife resources (mainly birds and bats) from wind turbine installations. With wind power development expanding throughout North America and Europe, concerns have surfaced over the number of bird fatalities associated with wind turbines. Guidelines developed for the wind industry by the National Wind Coordinating Committee (NWCC) recommend assessing potential impacts to birds, bats, and other potentially sensitive resources before construction. The primary purpose of an assessment is to identify potential conflicts with sensitive resources, to assist developers with identifying their permitting needs, and to develop strategies to avoid impacts or to mitigate their effects. This report provides a preliminary (Phase I) biological assessment of potential impacts to birds and bats that might result from construction and operation of the proposed wind energy facilities on VAFB.

Hydrothermal Liquefaction Treatment Preliminary Hazard Analysis Report

Energy Technology Data Exchange (ETDEWEB)

Lowry, Peter P.; Wagner, Katie A.

2015-08-31

A preliminary hazard assessment was completed during February 2015 to evaluate the conceptual design of the modular hydrothermal liquefaction treatment system. The hazard assessment was performed in 2 stages. An initial assessment utilizing Hazard Identification and Preliminary Hazards Analysis (PHA) techniques identified areas with significant or unique hazards (process safety-related hazards) that fall outside of the normal operating envelope of PNNL and warranted additional analysis. The subsequent assessment was based on a qualitative What-If analysis. This analysis was augmented, as necessary, by additional quantitative analysis for scenarios involving a release of hazardous material or energy with the potential for affecting the public.

Biomarkers in rheumatic diseases: how can they facilitate diagnosis and assessment of disease activity?

Science.gov (United States)

Mohan, Chandra; Assassi, Shervin

2015-11-26

Serological and proteomic biomarkers can help clinicians diagnose rheumatic diseases earlier and assess disease activity more accurately. These markers have been incorporated into the recently revised classification criteria of several diseases to enable early diagnosis and timely initiation of treatment. Furthermore, they also facilitate more accurate subclassification and more focused monitoring for the detection of certain disease manifestations, such as lung and renal involvement. These biomarkers can also make the assessment of disease activity and treatment response more reliable. Simultaneously, several new serological and proteomic biomarkers have become available in the routine clinical setting--for example, a protein biomarker panel for rheumatoid arthritis and a myositis antibody panel for dermatomyositis and polymyositis. This review will focus on commercially available antibody and proteomic biomarkers in rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis (scleroderma), dermatomyositis and polymyositis, and axial spondyloarthritis (including ankylosing spondylitis). It will discuss how these markers can facilitate early diagnosis as well as more accurate subclassification and assessment of disease activity in the clinical setting. The ultimate goal of current and future biomarkers in rheumatic diseases is to enable early detection of these diseases and their clinical manifestations, and to provide effective monitoring and treatment regimens that are tailored to each patient's needs and prognosis. © BMJ Publishing Group Ltd 2015.

[A preliminary study of low dosage zuclopenthixol depot in Alzheimer's disease].

Science.gov (United States)

Robles, A; Rodríguez Navarrete, F J; Taboada, O; Docasar, L; Páramo, M; Noya, M

1996-03-01

Persistent psychomotor agitation and psychotic ideation in patients with Alzheimer's disease are normally treated orally with antipsychotic drugs and are occasionally treated with other drugs. Neuroleptics administered intramuscularly at very low doses are an alternative, especially when the patient rejects medicine as a results of his or her anosognosia or of paranoid manifestations. We present the results we obtained after observing the effects of depot zuclopenthixol in six patients with probable Alzheimer's disease (based upon NINCDS-ADRDA criteria). Psychic abnormalities were assessed as per the Brief Psychiatric Rating Scale (BPRS), the Scale for the Assessment of Positive Symptoms (SAPS) and the Scale for the Assessment of Negative Symptoms (SANS). Possible extrapyramidal side effects were evaluated by means of the Abnormal Involuntary Movement Scale (AIMS). Initially 60 mg (0.3 ml) were administered intramuscularly and successive doses could be modified by +/-20 mg (0.1 ml) according to results seen on the various scales. During the first six weeks of treatment progressive improvement was noted on all three psychic functions scales in all patients. Between the sixth and twelfth weeks improvement continued although without significant change. The AIMS did not show significant changes in the twelve weeks of follow-up. We consider depot zuclopenthixol at low doses as efficacious in treating persistent psychomotor agitation and/or psychotic manifestations of Alzheimer's disease. No undesired side effects were observed in our group after a twelve week follow-up.

Waste to biodiesel: A preliminary assessment for Saudi Arabia.

Science.gov (United States)

Rehan, M; Gardy, J; Demirbas, A; Rashid, U; Budzianowski, W M; Pant, Deepak; Nizami, A S

2018-02-01

This study presents a preliminary assessment of biodiesel production from waste sources available in the Kingdom of Saudi Arabia (KSA) for energy generation and solution for waste disposal issues. A case study was developed under three different scenarios: (S1) KSA population only in 2017, (S2) KSA population and pilgrims in 2017, and (S3) KSA population and pilgrims by 2030 using the fat fraction of the municipal solid waste. It was estimated that S1, S2, and S3 scenarios could produce around 1.08, 1.10 and 1.41 million tons of biodiesel with the energy potential of 43423, 43949 and 56493 TJ respectively. Furthermore, annual savings of US $55.89, 56.56 and 72.71 million can be generated from landfill diversion of food waste and added to the country's economy. However, there are challenges in commercialization of waste to biodiesel facilities in KSA, including waste collection and separation, impurities, reactor design and biodiesel quality. Copyright © 2017 Elsevier Ltd. All rights reserved.

Distribution and preliminary exposure assessment of bisphenol AF (BPAF) in various environmental matrices around a manufacturing plant in China.

Science.gov (United States)

Song, Shanjun; Ruan, Ting; Wang, Thanh; Liu, Runzeng; Jiang, Guibin

2012-12-18

Increasing attention has been paid to bisphenol A and bisphenol (BP) analogues due to high production volumes, wide usage and potential adverse effects. Bisphenol AF (BPAF) is considered a new bisphenol analogue which is used as raw material in plastic industry, but little is known about its occurrence in the environment and the potential associated risk. In this work, BPAF levels and environmental distribution were reported in samples collected around a manufacturing plant and a preliminary exposure risk assessment to local residents was conducted. BPAF was detected in most of the samples, with levels in river ranging between environment and organic carbon was the domain factor during the process. The preliminary BPAF exposure assessment based on the CSOIL model suggested that children could have higher intake of BPAF than adults through inhalation of soils, dermal exposure by soils contact and bathing with well water.

Assessment of Crohn's disease activity in the small bowel with MR and conventional enteroclysis: preliminary results

International Nuclear Information System (INIS)

Gourtsoyiannis, Nicholas; Papanikolaou, Nickolas; Grammatikakis, John; Papamastorakis, George; Prassopoulos, Panos; Roussomoustakaki, Maria

2004-01-01

Every single imaging finding that can be disclosed on conventional and MR enteroclysis was correlated with the Crohn's disease activity index (CDAI). Nineteen consecutive patients with Crohn's disease underwent colon endoscopy and both conventional and MR enteroclysis examinations. Seventeen MR imaging findings and seven conventional enteroclysis findings were ranked on a four-point grading scale and correlated with CDAI, with a value of 150 considered as the threshold for disease activity. Six patients had active disease in the colon according to colon endoscopy. In the remaining 13 patients, the presence of deep ulcers (P=0.002), small bowel wall thickening (P=0.022) and gadolinium enhancement of mesenteric lymph nodes (P=0.014) identified on MR enteroclysis images were strongly correlated to disease activity. The product of deep ulcers and enhancement of lymph node ranks identified on MR enteroclysis were the optimum combination for discriminating active from non-active disease (F-test: 55.95, P<0.001). Additionally, the ranking of deep ulcers on conventional enteroclysis provided statistically significant differences between active and non-active patients (F-test: 14.12, P=0.004). Abnormalities strongly suggestive of active Crohn's disease can be disclosed on MR enteroclysis examinations and may provide pictorial information for local inflammatory activity. (orig.)

Contrast-enhanced ultrasonography for the determination of Crohn's disease activity - preliminary experience.

Science.gov (United States)

Białecki, Marcin; Białecka, Agnieszka; Laskowska, Katarzyna; Kłopocka, Maria; Liebert, Ariel; Lemanowicz, Adam; Serafin, Zbigniew

2014-01-01

Contrast-enhanced ultrasound (CEUS) is a recent non-invasive modality, which may partially replace currently used techniques (endoscopy, CT enterography and MR enterography) in the diagnostics and assessment of Crohn's disease (CD). The aim of the study was to analyze early experience in the use of CEUS for the measurement of activity and staging of CD. Eleven patients previously diagnosed with CD were included in the study. They underwent contrast-enhanced ultrasonography (SonoVue, Bracco), low-dose CT enterography (LDCTE), assessment of laboratory markers of inflammation and clinical CD activity index (CDAI). Contrast enhancement was evaluated using a semi-quantitative method and a quantitative method that included measurement of peak enhancement (PE), enhancement curve rise time (RT) and wash-in-rate (WiR). Ileal wall thickening was observed in all patients. Semi-quantitative method was used to observe CD activity in CEUS in 10 cases that perfectly matched LDCTE findings. There was a moderate positive correlation between PE and CDAI (r=0.65, p<0.001). There was no significant relationship between perfusion parameters and laboratory markers of inflammation. CEUS is a promising modality for non-invasive assessment of pathologic ileal vascularization in the course of Crohn's disease. Intensity of enhancement in CEUS reflects activity of the disease detected in LDCTE and correlates with CDAI.

Validation and clinical significance of the Childhood Myositis Assessment Scale for assessment of muscle function in the juvenile idiopathic inflammatory myopathies.

Science.gov (United States)

Huber, Adam M; Feldman, Brian M; Rennebohm, Robert M; Hicks, Jeanne E; Lindsley, Carol B; Perez, Maria D; Zemel, Lawrence S; Wallace, Carol A; Ballinger, Susan H; Passo, Murray H; Reed, Ann M; Summers, Ronald M; White, Patience H; Katona, Ildy M; Miller, Frederick W; Lachenbruch, Peter A; Rider, Lisa G

2004-05-01

To examine the measurement characteristics of the Childhood Myositis Assessment Scale (CMAS) in children with juvenile idiopathic inflammatory myopathy (juvenile IIM), and to obtain preliminary data on the clinical significance of CMAS scores. One hundred eight children with juvenile IIM were evaluated on 2 occasions, 7-9 months apart, using various measures of physical function, strength, and disease activity. Interrater reliability, construct validity, and responsiveness of the CMAS were examined. The minimum clinically important difference (MID) and CMAS scores corresponding to various degrees of physical disability were estimated. The intraclass correlation coefficient for 26 patients assessed by 2 examiners was 0.89, indicating very good interrater reliability. The CMAS score correlated highly with the Childhood Health Assessment Questionnaire (C-HAQ) score and with findings on manual muscle testing (MMT) (r(s) = -0.73 and 0.73, respectively) and moderately with physician-assessed global disease activity and skin activity, parent-assessed global disease severity, and muscle magnetic resonance imaging (r(s) = -0.44 to -0.61), thereby demonstrating good construct validity. The standardized response mean was 0.81 (95% confidence interval 0.53, 1.09) in patients with at least 0.8 cm improvement on a 10-cm visual analog scale for physician-assessed global disease activity, indicating strong responsiveness. In bivariate regression models predicting physician-assessed global disease activity, MMT remained significant in models containing the CMAS (P = 0.03) while the C-HAQ did not (P = 0.4). Estimates of the MID ranged from 1.5 to 3.0 points on a 0-52-point scale. CMAS scores corresponding to no, mild, mild-to-moderate, and moderate physical disability, respectively, were 48, 45, 39, and 30. The CMAS exhibits good reliability, construct validity, and responsiveness, and is therefore a valid instrument for the assessment of physical function, muscle strength, and

Preliminary Assessment of a Compliant Gait Exoskeleton.

Science.gov (United States)

Cestari, Manuel; Sanz-Merodio, Daniel; Garcia, Elena

2017-06-01

Current commercial wearable gait exoskeletons contain joints with stiff actuators that cannot adapt to unpredictable environments. These actuators consume a significant amount of energy, and their stiffness may not be appropriate for safe human-machine interactions. Adjustable compliant actuators are being designed and implemented because of their ability to minimize large forces due to shocks, to safely interact with the user, and to store and release energy in passive elastic elements. Introduction of such compliant actuation in gait exoskeletons, however, has been limited by the larger power-to-weight and volume ratio requirement. This article presents a preliminary assessment of the first compliant exoskeleton for children. Compliant actuation systems developed by our research group were integrated into the ATLAS exoskeleton prototype. The resulting device is a compliant exoskeleton, the ATLAS-C prototype. The exoskeleton is coupled with a special standing frame to provide balance while allowing a semi-natural gait. Experiments show that when comparing the behavior of the joints under different stiffness conditions, the inherent compliance of the implemented actuators showed natural adaptability during the gait cycle and in regions of shock absorption. Torque tracking of the joint is achieved, identifying the areas of loading response. The implementation of a state machine in the control of knee motion allowed reutilization of the stored energy during deflection at the end of the support phase to partially propel the leg and achieve a more natural and free swing.

Preliminary Guideline for the High Temperature Structure Integrity Assessment Procedure Part II. High Temperature Structural Integrity Assessment

Energy Technology Data Exchange (ETDEWEB)

Lee, Jae Han; Kim, J. B.; Lee, H. Y.; Park, C. G.; Joo, Y. S.; Koo, G. H.; Kim, S. H

2007-02-15

A high temperature structural integrity assessment belongs to the Part II of a whole preliminary guideline for the high temperature structure. The main contents of this guideline are the evaluation procedures of the creep-fatigue crack initiation and growth in high temperature condition, the high temperature LBB evaluation procedure, and the inelastic evaluations of the welded joints in SFR structures. The methodologies for the proper inelastic analysis of an SFR structures in high temperatures are explained and the guidelines of inelastic analysis options using ANSYS and ABAQUS are suggested. In addition, user guidelines for the developed NONSTA code are included. This guidelines need to be continuously revised to improve the applicability to the design and analysis of the SFR structures.

Assessing the Penetrating Abilities of Experimental Preparation with Dental Infiltrant Features Using Optical Microscope: Preliminary Study.

Science.gov (United States)

Skucha-Nowak, Małgorzata; Machorowska-Pieniążek, Agnieszka; Tanasiewicz, Marta

2016-01-01

The aim of the infiltration technique is to penetrate demineralized enamel with a low viscosity resin. Icon® (DMG) is the first ever and so far the only dental infiltrant. Bacteriostaticity is one of the properties that should be inherent in dental infiltrants, but Icon lacks this feature. The aim of the preliminary study was to properly choose a dye which would allow us to assess the penetrating abilities of our own, experimental preparation with features of a dental infiltrant with bacteriostatic properties and to compare using an optical microscope the depth of infiltration of the designed experimental preparation with the infiltrant available on the market. The preparation is supposed to infiltrate decalcified human enamel and be assessed with an optical microscope. Eosin, neutral fuchsine and methylene blue were added to experimental preparation with dental infiltrant features and to Icon® (DMG) in order to assess the depth of penetration of the experimental solution into the decalcified layers of enamel. The experimental solution mixes well with eosin, neutral fuchsine, and methylene blue. During the preliminary study, the authors concluded that the experimental solution mixes well with methylene blue, neutral fuchsine, and eosin. An addition of eosin to a preparation which infiltrates inner, demineralized enamel layers, facilitates the assessment of such a preparation with an optical microscope. A designed experimental solution with the main ingredients, i.e., 2-hydroxyethyl methacrylate (HEMA) and tetraethylene glycol dimethacrylate (TEGDMA) with a ratio of 75% to 25% penetrates the demineralized (decalcified) inner parts of the enamel and polymerizes when exposed to light. In order to assess the infiltration of the experimental solution into the demineralized enamel layers, it is required to improve the measurement techniques that utilize optical microscopy.

Assessment of Nano Cellulose from Peach Palm Residue as Potential Food Additive: Part II: Preliminary Studies.

Science.gov (United States)

Andrade, Dayanne Regina Mendes; Mendonça, Márcia Helena; Helm, Cristiane Vieira; Magalhães, Washington L E; de Muniz, Graciela Ines Bonzon; Kestur, Satyanarayana G

2015-09-01

High consumption of dietary fibers in the diet is related to the reduction of the risk of non-transmitting of chronic diseases, prevention of the constipation etc. Rich diets in dietary fibers promote beneficial effects for the metabolism. Considering the above and recognizing the multifaceted advantages of nano materials, there have been many attempts in recent times to use the nano materials in the food sector including as food additive. However, whenever new product for human and animal consumption is developed, it has to be tested for their effectiveness regarding improvement in the health of consumers, safety aspects and side effects. However, before it is tried with human beings, normally such materials would be assessed through biological tests on a living organism to understand its effect on health condition of the consumer. Accordingly, based on the authors' finding reported in a previous paper, this paper presents body weight, biochemical (glucose, cholesterol and lipid profile in blood, analysis of feces) and histological tests carried out with biomass based cellulose nano fibrils prepared by the authors for its possible use as food additive. Preliminary results of the study with mice have clearly brought out potential of these fibers for the said purpose.

Preliminary assessment of the computer-based Taenia solium educational program 'The Vicious Worm' on knowledge uptake in primary school students in rural areas in eastern Zambia.

Science.gov (United States)

Hobbs, Emma C; Mwape, Kabemba Evans; Van Damme, Inge; Berkvens, Dirk; Zulu, Gideon; Mambwe, Moses; Chembensofu, Mwelwa; Phiri, Isaac Khozozo; Masuku, Maxwell; Bottieau, Emmanuel; Devleesschauwer, Brecht; Speybroeck, Niko; Colston, Angela; Dorny, Pierre; Willingham, Arve Lee; Gabriël, Sarah

2018-03-01

The zoonotic helminth Taenia solium is endemic in Zambia, causing human (taeniasis and (neuro)cysticercosis) and pig (porcine cysticercosis) diseases with high health, social and economic burdens. We aimed to evaluate the impact of a health educational program intended to lead to powerful and cumulative improvements in knowledge, attitudes and practices that decrease parasite transmission and disease occurrence. Half-day health education workshops were conducted in three primary schools in the highly endemic Eastern Province of Zambia, using the computer-based T. solium educational program 'The Vicious Worm'. Questionnaires were administered before and after the educational component to determine the program's impact on knowledge uptake in primary school students. In total, 99 students participated: 38 males and 61 females, with a median age of 14 years (range 10-18 years). Baseline general knowledge of T. solium, including awareness of the different human and pig disease states, and disease diagnosis, treatment and prevention, was quite high (average score 62%) and consistent across all three study areas. Participants' knowledge had significantly increased after the educational component, particularly regarding parasite transmission and disease prevention. Preliminary assessment of 'The Vicious Worm' indicates it is an effective tool for the short-term T. solium education of primary school students in Zambia. Follow-up studies are planned to assess the longer term impact of the program on knowledge uptake in the study neighbourhoods. Inclusion of tailored 'The Vicious Worm' educational workshops should be considered in integrated cysticercosis control programs in endemic areas of sub-Saharan Africa. © 2018 The Authors. Tropical Medicine & International Health Published by John Wiley & Sons Ltd.

A preliminary economic feasibility assessment of nuclear desalination in Madura Island

International Nuclear Information System (INIS)

Kim, S.-H.; Hwang, Y.-D.; Konishi, T.; Hudi Hastowo

2005-01-01

A joint study between KAERI and BATAN, which is entitled 'A preliminary economic feasibility assessment of nuclear desalination in Madura Island', is being conducted under the framework of the Interregional Technical Cooperation Project of IAEA, signed on Oct. 10, 2001 at IAEA. The duration of the project is January 2002 to December 2004. An economic feasibility of nuclear desalination using system-integrated modular advanced reactor (SMART), which will provide Madura Island with electricity and potable water and also support industrialisation and tourism, will be assessed during the project. The scope of this joint study includes the analyses for the short- and long-term energy and water demand as well as the supply plan for Madura Island, evaluation of the site characteristics, environmental impacts and health aspects, technical and economic evaluation of SMART and its desalination system, including the feasibility of its being identified on the Madura Island. KAERI and BATAN are cooperating in conducting a joint study, and IAEA provides technical support and a review of the study products. This paper presents the interim results of the joint study by focussing on the technical and economic aspects of nuclear desalination using SMART in Madura Island. (author)

Preliminary assessment report for Virginia Army National Guard Army Aviation Support Facility, Richmond International Airport, Installation 51230, Sandston, Virginia

International Nuclear Information System (INIS)

Dennis, C.B.

1993-09-01

This report presents the results of the preliminary assessment (PA) conducted by Argonne National Laboratory at the Virginia Army National Guard (VaARNG) property in Sandston, Virginia. The Army Aviation Support Facility (AASF) is contiguous with the Richmond International Airport. Preliminary assessments of federal facilities are being conducted to compile the information necessary for completing preremedial activities and to provide a basis for establishing corrective actions in response to releases of hazardous substances. The PA is designed to characterize the site accurately and determine the need for further action by examining site activities, quantities of hazardous substances present, and potential pathways by which contamination could affect public health and the environment. The AASF, originally constructed as an active Air Force interceptor base, provides maintenance support for VaARNG aircraft. Hazardous materials used and stored at the facility include JP-4 jet fuel, diesel fuel, gasoline, liquid propane gas, heating oil, and motor oil

Preliminary assessment report for Army Aviation Support Facility No. 3, Installation 13307, Hunter Army Airfield, Savannah, Georgia. Installation Restoration Program

Energy Technology Data Exchange (ETDEWEB)

Kolpa, R.; Smith, K.

1993-07-01

This report presents the results of the preliminary assessment (PA) conducted by Argonne National Laboratory at the Georgia Army National Guard property located on Hunter Army Airfield (HAA) near Savannah, Georgia, known as Army Aviation Support Facility (AASF) No. 3. Preliminary assessments of federal facilities are being conducted to compile the information necessary for completing preremedial activities and to provide a basis for establishing corrective actions in response to releases of hazardous substances. The principal objective of the PA is to characterize the site accurately and determine the need for further action by examining site activities, types and quantities of hazardous substances utilized, the nature and amounts of wastes generated or stored at the facility, and potential pathways by which contamination could affect public health and the environment. This PA satisfies, for the AASF No. 3 property, requirements of the Department of Defense Installation Restoration Program (IRP). The scope of this assessment is limited to the facilities and past activities contained within the area now occupied by AASF No. 3. However, this assessment report is intended to be read in conjunction with a previous IRP assessment of HAA completed in 1992 (USATHAMA 1992) and to provide comprehensive information on AASF No. 3 for incorporation with information contained in that previous assessment for the entirety of HAA.

A preliminary assessment of the market coupling arrangement on the Kontek cable

International Nuclear Information System (INIS)

Kristiansen, Tarjei

2007-01-01

This paper presents a preliminary assessment of the market coupling arrangement on the Kontek (KT) cable between East Denmark and Germany and an assessment of the original auction mechanism. KT, the new spot price area, was introduced in Germany on October 5, 2005 to facilitate a market coupling arrangement on the KT cable between East Denmark and Germany. We would expect the KT price to correlate more with the European Energy Exchange (EEX) price because arbitrage normally levelizes the price. However, spot prices in late 2005 were both high and volatile because congestion management practices in Sweden transferred internal bottlenecks to the cable between Sweden and East Denmark. Since spot prices were equal in East Denmark and the KT area for a substantial time, it implies that some hours had no congestion on the KT cable. Market players valued the previous monthly auctions for transmission capacity more than the daily auctions. Compared to the daily auctions, market players received smaller payoffs on average for the market coupling arrangement, and the smallest payoffs for the monthly auctions

Preliminary environmental assessment for the Satellite Power System (SPS). Revision 1. Volume 2. Detailed assessment

Energy Technology Data Exchange (ETDEWEB)

1980-01-01

The Department of Energy (DOE) is considering several options for generating electrical power to meet future energy needs. The satellite power system (SPS), one of these options, would collect solar energy through a system of satellites in space and transfer this energy to earth. A reference system has been described that would convert the energy to microwaves and transmit the microwave energy via directive antennas to large receiving/rectifying antennas (rectennas) located on the earth. At the rectennas, the microwave energy would be converted into electricity. The potential environmental impacts of constructing and operating the satellite power system are being assessed as a part of the Department of Energy's SPS Concept Development and Evaluation Program. This report is Revision I of the Preliminary Environmental Assessment for the Satellite Power System published in October 1978. It refines and extends the 1978 assessment and provides a basis for a 1980 revision that will guide and support DOE recommendations regarding future SPS development. This is Volume 2 of two volumes. It contains the technical detail suitable for peer review and integrates information appearing in documents referenced herein. The key environmental issues associated with the SPS concern human health and safety, ecosystems, climate, and electromagnetic systems interactions. In order to address these issues in an organized manner, five tasks are reported: (I) microwave-radiation health and ecological effects; (II) nonmicrowave health and ecological effectss; (III) atmospheric effects; (IV) effects on communication systems due to ionospheric disturbance; and (V) electromagnetic compatibility. (WHK)

Preliminary assessment of the dose to the interventional radiologist in fluoro-CT-guided procedures

International Nuclear Information System (INIS)

Pereira, M. F.; Alves, J. G.; Sarmento, S.; Santos, J. A. M.; Sousa, M. J.; Gouvea, M.; Oliveira, A. D.; Cardoso, J. V.; Santos, L. M.

2011-01-01

A preliminary assessment of the occupational dose to the intervention radiologist received in fluoroscopy computerised tomography (CT) used to guide the collection of lung and bone biopsies is presented. The main aim of this work was to evaluate the capability of the reading system as well as of the available whole-body (WB) and extremity dosemeters used in routine monthly monitoring periods to measure per procedure dose values. The intervention radiologist was allocated 10 WB detectors (LiF: Mg, Ti, TLD-100) placed at chest and abdomen levels above and below the lead apron, and at both right and left arms, knees and feet. A special glove was developed with casings for the insertion of 11 extremity detectors (LiF:Mg, Cu, P, TLD-100H) for the identification of the most highly exposed fingers. The H p (10) dose values received above the lead apron (ranged 0.20-0.02 mSv) depend mainly on the duration of the examination and on the placement of physician relative to the beam, while values below the apron are relatively low. The left arm seems to receive a higher dose value. H p (0.07) values to the hand (ranged 36.30-0.06 mSv) show that the index, middle and ring fingers are the most highly exposed. In this study, the wrist dose was negligible compared with the finger dose. These results are preliminary and further studies are needed to better characterise the dose assessment in CT fluoroscopy. (authors)

Assessment of Motor Units in Neuromuscular Disease.

Science.gov (United States)

Henderson, Robert D; McCombe, Pamela A

2017-01-01

The motor unit comprises the anterior horn cell, its axon, and the muscle fibers that it innervates. Although the true number of motor units is unknown, the number of motor units appears to vary greatly between different muscles and between different individuals. Assessment of the number and function of motor units is needed in diseases of the anterior horn cell and other motor nerve disorders. Amyotrophic lateral sclerosis is the most important disease of anterior horn cells. The need for an effective biomarker for assessing disease progression and for use in clinical trials in amyotrophic lateral sclerosis has stimulated the study of methods to measure the number of motor units. Since 1970 a number of different methods, including the incremental, F-wave, multipoint, and statistical methods, have been developed but none has achieved widespread applicability. Two methods (MUNIX and the multipoint incremental method) are in current use across multiple centres and are discussed in detail in this review, together with other recently published methods. Imaging with magnetic resonance and ultrasound is increasingly being applied to this area. Motor unit number estimates have also been applied to other neuromuscular diseases such as spinal muscular atrophy, compression neuropathies, and prior poliomyelitis. The need for an objective measure for the assessment of motor units remains tantalizingly close but unfulfilled in 2016.

Assessment of validation of health-economics decision models in intervention studies of seasonal influenza and breast cancer

NARCIS (Netherlands)

De Boer, P.T.; Frederix, G.W.; Al, M.J.; Feenstra, T.F.; Vemer, P.

2015-01-01

Objectives: We aimed to review recently published health-economic (HE) decision models to assess the reporting of validation efforts. An infectious disease (seasonal influenza, SI) and a chronic disease (breast cancer, BC) were used as examples, giving a preliminary insight in the reporting of

Dealing with uncertainties in environmental burden of disease assessment

Directory of Open Access Journals (Sweden)

van der Sluijs Jeroen P

2009-04-01

Full Text Available Abstract Disability Adjusted Life Years (DALYs combine the number of people affected by disease or mortality in a population and the duration and severity of their condition into one number. The environmental burden of disease is the number of DALYs that can be attributed to environmental factors. Environmental burden of disease estimates enable policy makers to evaluate, compare and prioritize dissimilar environmental health problems or interventions. These estimates often have various uncertainties and assumptions which are not always made explicit. Besides statistical uncertainty in input data and parameters – which is commonly addressed – a variety of other types of uncertainties may substantially influence the results of the assessment. We have reviewed how different types of uncertainties affect environmental burden of disease assessments, and we give suggestions as to how researchers could address these uncertainties. We propose the use of an uncertainty typology to identify and characterize uncertainties. Finally, we argue that uncertainties need to be identified, assessed, reported and interpreted in order for assessment results to adequately support decision making.

Assessment and management of refractory breathlessness in interstitial lung disease.

Science.gov (United States)

Speakman, Lucy; Walthall, Helen

2017-09-02

Interstitial lung disease (ILD) refers to a cluster of fibroinflammatory conditions. There are limited treatment options and most patients have severe dyspnoea. The prognosis is poor. This study aims to evaluate current literature on the assessment and management of refractory breathlessness in ILD. Few tools are available to assess dyspnoea in advanced respiratory disease. Holistic assessment requires a combination of tools but there are few disease specific tools. The role of opioids is well established in the reduction of breathlessness, but there is insufficient evidence that benzodiazepines are beneficial. Non-pharmcolological breathlessness intervention services can give patients mastery of their disease, reduced distress due to breathlessness and were more cost effective. More research on holistic interventions for use in advanced disease needs to be done. Patient-reported outcome measures could elicit valuable evidence to describe the benefit of breathlessness management services in advanced respiratory disease.

myTREEHOUSE Self-Concept Assessment: preliminary psychometric analysis of a new self-concept assessment for children with cerebral palsy.

Science.gov (United States)

Cheong, Sau Kuan; Lang, Cathryne P; Hemphill, Sheryl A; Johnston, Leanne M

2017-06-01

To evaluate the preliminary validity and reliability of the myTREEHOUSE Self-Concept Assessment for children with cerebral palsy (CP) aged 8 to 12 years. The myTREEHOUSE Self-Concept Assessment includes 26 items divided into eight domains, assessed across three Performance Perspectives (Personal, Social, and Perceived) and an additional Importance Rating. Face and content validity was assessed by semi-structured interviews with seven expert professionals regarding the assessment construct, content, and clinical utility. Reliability was assessed with 50 children aged 8 to 12 years with CP (29 males, 21 females; mean age 10y 2mo; Gross Motor Function Classification System [GMFCS] level I=35, II=8, III=5, IV=1; mean Wechsler Intelligence Scale for Children - Fourth Edition [WISC-IV]=104), whose data was used to calculate internal consistency of the scale, and a subset of 35 children (20 males, 15 females; mean age 10y 5mo; GMFCS level I=26, II=4, III=4, IV=1; mean WISC-IV=103) who participated in test-retest reliability within 14 to 28 days. Face and content validity was supported by positive expert feedback, with only minor adjustments suggested to clarify the wording of some items. After these amendments, strong internal consistency (Cronbach's α 0.84-0.91) and moderate to good test-retest reliability (intraclass correlation coefficient 0.64-0.75) was found for each component. The myTREEHOUSE Self-Concept Assessment is a valid and reliable assessment of self-concept for children with CP aged 8 to 12 years. © 2017 Mac Keith Press.

Research and development of technologies for safe and environmentally optimal recovery and disposal of explosive wastes. Task 2, Preliminary impact assessment for environment, health and safety (EIA)

Energy Technology Data Exchange (ETDEWEB)

Duijm, N.J.; Markert, F. [Risoe (Denmark); Larsen, S.G. [DEMEX A/S (Denmark)

1998-09-01

As described in the project proposal `Research and Development of Technologies for Safe and Environmentally optimal recovery and Disposal of Explosive Wastes`, dated 31. May 1996, the objective of Task 2, Preliminary Impact Assessment for Environment, Health and Safety, is to: Analyse the environmental impact of noise and emissions to air, water and soil; Assess the risk of hazards to workers` health and safety and to the public. Task 2, Preliminary Impact Assessment for Environment, Health and Safety (EIA), has been performed from August 1997 to September 1998. First, a methodology has been established, based on Multi-Criteria Decision Analysis (MCDA), to select the `best` technology on the basis of clearly defined objectives, including minimal impacts on environment, health and safety. This included a review of different types of explosive waste with a focus on the environment implications, identifying the issues relevant to defining the criteria or objectives with respect to environment and safety in the framework of explosive waste, as well as the preliminary definition of objectives for the final impact assessment. Second, the previously identified recovery and disposal technologies (Task 1) have been qualitatively assessed on the basis of the relevant objectives. This qualitative assessment includes also economic considerations and an attempt to rank the technologies in an MCDA framework. (au)

Total cardiovascular disease risk assessment: a review.

LENUS (Irish Health Repository)

Cooney, Marie Therese

2011-09-01

The high risk strategy for the prevention of cardiovascular disease (CVD) requires an assessment of an individual\\'s total CVD risk so that the most intensive risk factor management can be directed towards those at highest risk. Here we review developments in the assessment and estimation of total CVD risk.

A preliminary assessment of the potential risks from electrical ...

African Journals Online (AJOL)

... Grey-crowned Crane Balearica regulorum, Lesser Flamingo Phoeniconaias minor, White-backed Vulture Gyps africanus, Rüppell's Vulture Gyps rueppellii, Martial Eagle Polemaetus bellicosus, White Stork Ciconia ciconia, Secretarybird Sagittarius serpentarius, and various sit-and-wait raptors. These preliminary findings ...

An Instrument to Assess Self-Statements During Public Speaking: Scale Development and Preliminary Psychometric Properties

Science.gov (United States)

Hofmann, Stefan G.; DiBartolo, Patricia Marten

2006-01-01

Public speaking is the most commonly reported fearful social situation. Although a number of contemporary theories emphasize the importance of cognitive processes in social anxiety, there is no instrument available to assess fearful thoughts experienced during public speaking. The Self-Statements During Public Speaking (SSPS) scale is a 10-item questionnaire consisting of two 5-item subscales, the “Positive Self-Statements” (SSPS-P) and the “Negative Self-Statements” subscale (SSPS-N). Four studies report on the development and the preliminary psychometric properties of this instrument. PMID:16763666

A Preliminary Investigation of ADHD Symptoms in Persons with Celiac Disease

Science.gov (United States)

Niederhofer, Helmut; Pittschieler, Klaus

2006-01-01

Objective: Several studies report a possible association of celiac disease (CD) with psychiatric and psychological disturbances, such as ADHD. Method: The authors assess 132 participants from 3 to 57 years of age (M = 19.3 years) affected by CD for the possibility of an associated ADHD-like symptomatology, using the Conner Scale Hypescheme, a…

A preliminary assessment of the radiological impact of the Chernobyl reactor accident on the population of the European Community

International Nuclear Information System (INIS)

Morrey, M.; Brown, J.; Williams, J.A.; Crick, M.J.; Simmonds, J.R.; Hill, M.D.

1988-01-01

Following the Chernobyl accident the Commission of the European Communities asked the National Radiological Protection Board to carry out a preliminary assessment of the radiological consequences of the accident on the population of the European Community (EC). The aim of the study was to review information on the environmental contamination measured in member states of the EC; to make a preliminary assessment of individual and population doses for each country; to make an estimate of the resulting health impact and to indicate the effects of the various countermeasures taken by member states in terms of the reductions in both individual and population exposure which they produced. All of the main pathways by which people have been and will be exposed to radiation as a result of the accident were included in the assessment. The impact estimate is based on environmental measurements made during the month after the accident, and on calculations made using mathematical models of radionuclide transfer through the environment. The calculated effective doses to average individuals in EC countries from exposure over the next 50 years range from 0.3 μSv (in Portugal) to between about 300 and 500 μSv (in the FRG, Italy and Greece). The total collective effective dose to the population of EC countries, integrated over all time, is estimated to be about 80 000 man Sv. This may be compared to the collective effective dose from natural background radiation of about 500 000 man Sv every year. In some countries, the restrictions placed on consumption of some foods are estimated to have been effective in reducing doses to the most exposed individuals; the reduction being up to about a factor of 2. The results presented in this paper should therefore be regarded as preliminary

Health assessment of environmental pollutants: proliferative and degenerative diseases

International Nuclear Information System (INIS)

Stuart, B.O.

1988-01-01

In order to achieve a balanced approach to risk assessment between carcinogenic and non-carcinogenic health effects one must examine the risk of disease or death in the general population exposed to a particular air pollutant that can be related quantitatively to intensity and duration of exposures (National Academy of Sciences, 1983). Such risk assessment should be based upon careful evaluation of scientific findings of dose-response relationships in the chronically exposed population. Quantitative assessment of environmentally produced disease in man has proven to be complex and demanding. A variety of factors play important roles in this task. As an example, there are induction-latency periods for chronic diseases, including cancer, which may range from five to twenty-five years. The diseases themselves, whether proliferative or degenerative, may follow several stages of progression. There is only sparse epidemiological data on serious health effects that may be due to environmental as compared to occupational exposures. Exposures to chemical or radiological air contaminants do not occur singly but to a multiplicity of agents, and disease processes are frequently markedly affected by the interaction of a variety of factors, particularly that of cigarette smoking. There is growing recognition of potentially sensitive subpopulations, including the elderly and the very young, but adequate techniques for assessing the magnitude of increased risks to these groups have not yet been developed

Adapting the helpful responses questionnaire to assess communication skills involved in delivering contingency management: preliminary psychometrics.

Science.gov (United States)

Hartzler, Bryan

2015-08-01

A paper/pencil instrument, adapted from Miller and colleagues' (1991) Helpful Responses Questionnaire (HRQ), was developed to assess clinician skill with core communicative aspects involved in delivering contingency management (CM). The instrument presents a single vignette consisting of six points of client dialogue to which respondents write 'what they would say next.' In the context of an implementation/effectiveness hybrid trial, 19 staff clinicians at an opiate treatment program completed serial training outcome assessments before, following, and three months after CM training. Assessments included this adaptation of the HRQ, a multiple-choice CM knowledge test, and a recorded standardized patient encounter scored for CM skillfulness. Study results reveal promising psychometric properties for the instrument, including strong scoring reliability, internal consistency, concurrent and predictive validity, test-retest reliability and sensitivity to training effects. These preliminary findings suggest the instrument is a viable, practical method to assess clinician skill in communicative aspects of CM delivery. Copyright © 2015 Elsevier Inc. All rights reserved.

Vulnerability Assessments and Resilience Planning at Federal Facilities. Preliminary Synthesis of Project

Energy Technology Data Exchange (ETDEWEB)

Moss, R. H. [Pacific Northwest National Lab. (PNNL)/Univ. of Maryland, College Park, MD (United States). Joint Global Change Research Inst.; Blohm, A. J. [Univ. of Maryland, College Park, MD (United States); Delgado, A. [Pacific Northwest National Lab. (PNNL)/Univ. of Maryland, College Park, MD (United States). Joint Global Change Research Inst.; Henriques, J. J. [James Madison Univ., Harrisonburg, VA (United States); Malone, E L. [Pacific Northwest National Lab. (PNNL)/Univ. of Maryland, College Park, MD (United States). Joint Global Change Research Inst.

2015-08-15

U.S. government agencies are now directed to assess the vulnerability of their operations and facilities to climate change and to develop adaptation plans to increase their resilience. Specific guidance on methods is still evolving based on the many different available frameworks. Agencies have been experimenting with these frameworks and approaches. This technical paper synthesizes lessons and insights from a series of research case studies conducted by the investigators at facilities of the U.S. Department of Energy and the Department of Defense. The purpose of the paper is to solicit comments and feedback from interested program managers and analysts before final conclusions are published. The paper describes the characteristics of a systematic process for prioritizing needs for adaptation planning at individual facilities and examines requirements and methods needed. It then suggests a framework of steps for vulnerability assessments at Federal facilities and elaborates on three sets of methods required for assessments, regardless of the detailed framework used. In a concluding section, the paper suggests a roadmap to further develop methods to support agencies in preparing for climate change. The case studies point to several preliminary conclusions; (1) Vulnerability assessments are needed to translate potential changes in climate exposure to estimates of impacts and evaluation of their significance for operations and mission attainment, in other words into information that is related to and useful in ongoing planning, management, and decision-making processes; (2) To increase the relevance and utility of vulnerability assessments to site personnel, the assessment process needs to emphasize the characteristics of the site infrastructure, not just climate change; (3) A multi-tiered framework that includes screening, vulnerability assessments at the most vulnerable installations, and adaptation design will efficiently target high-risk sites and infrastructure

Preliminary assessment of future refining impacts of the Clean Air Act Amendments of 1990

International Nuclear Information System (INIS)

Hadder, G.R.

1991-09-01

A preliminary assessment of the future refining impacts of the Clean Air Act Amendments of 1990 has been performed with the Navy Mobility Fuels Forecasting Systems. The assessment suggests that gasoline reformulation costs in domestic coastal and near-coastal refining regions in the year 2000 could be 3.5 to 5.6 cents per gallon (in terms of 1989 currency). For heating value equivalent to one gallon of conventional gasoline, the regional total added costs (including reformulation costs) for reformulated gasoline could be 5.9 to 8.0 cents. In blending reformulated gasolines, the reduction of butane for lower Reid vapor pressure and the reduction of reformate for lower aromatics are generally compensated by increased percentages of alkylate and/or straight run naphthas. Relatively larger refinery process capacity additions are required for butane isomerization, alkylation, aromatics recovery, and distillate hydrotreating. 21 refs., 3 figs., 18 tabs

Radiological assessement of Crohn's disease

International Nuclear Information System (INIS)

Florio, F.; Palladino, M.; Stella, P.; Barbi, E.

1987-01-01

Fifty-eight consecutive cases of patients affected by Crohn's disease, with ileum (23/58), colon (10/58) and ileo-colic (25/58) involvement were studied. A good overall sensitivity was reached by the radiological procedures employed (barium meal, barium enema, enterclysis). Enterclysis is proposed as a second-step method for the study of ileum involvement, because it provides a quite precise assessement of disease stage and extent. Some criteria for a rational use of current radiological procedures in follow-up of both surgically and medically treated patients are proposed. Moreover it is suggested that better coordination of anatomo-radiological and clinical aspects could improve the therapeutic approach and prognostic judgement in such cases

CT virtual intravascular endoscopy assessment of coronary artery plaques: A preliminary study

International Nuclear Information System (INIS)

Sun Zhonghua; Dimpudus, Franky Jacobus; Nugroho, Johanes; Adipranoto, Jeffrey Daniel

2010-01-01

Purpose: The purpose of this study was to investigate the potential value of CT virtual intravascular endoscopy (VIE) in the visualization and assessment of coronary plaques in patients suspected of coronary artery disease. Materials and methods: 20 (13 men, 7 women, mean age 54 years) consecutive patients with suspected coronary artery disease undergoing 64-slice CT angiography were included in the study. Four main coronary artery branches were assessed with regard to the presence of coronary plaques based on 2D axial, multiplanar reformation, 3D volume rendering and VIE visualizations. The coronary plaques were characterized into calcified, noncalcified and mixed plaques. The intraluminal appearances of these coronary plaques were demonstrated with VIE images and correlated with 2D and 3D images to determine the diagnostic value of VIE for the assessment of the plaques. Results: VIE was able to identify and demonstrate the intraluminal appearances of coronary plaques in 18 patients involving 32 coronary artery branches which were shown as an irregularly intraluminal protruding sign in extensively calcified plaques and smooth protruding appearance in noncalcified or focally calcified plaques. An irregular intraluminal appearance was also noticed in the presence of mixed plaques due to variable components with different CT attenuations contained within the plaques. VIE accurately confirmed the degree of coronary stenosis or occlusion despite the presence of heavy calcification. Conclusion: VIE could be used as a complementary tool to conventional CT visualizations for the analysis of luminal changes and assessment of disease extent caused by the coronary plaques.

Preliminary assessment of the gender aspects of disaster vulnerability and loss of human life in South Africa

OpenAIRE

Tandlich, Roman; Chirenda, Tatenda G; Srinivas, Chandra S S

2013-01-01

South Africa has reached a medium level of human development and has a heterogeneous situation with respect to disaster risk management. In this article, a preliminary assessment of the gender aspects of disaster vulnerability and fatalities is presented. The United Nations, the Health Systems Trust and Statistics South Africa were used as data sources for the following gender-segregated values: the life expectancy at birth, unemployment rates, the human development index values, the maternal...

Assessing antiquity and turnover of terrestrial ecosystems in eastern North America using fossil pollen data: A preliminary study

International Nuclear Information System (INIS)

Liu Yao; Jackson, Stephen T; Brewer, Simon; Williams, John W

2010-01-01

We explored formal approaches to identifying and interpreting the antiquity and turnover of terrestrial ecosystems in eastern North America using pollen records. Preliminary results of cluster analyses, receiver-operating characteristic (ROC) analyses, and likelihood estimation of ecosystem analog in a simple Bayesian model allow assessment of modern ecosystem antiquities and past ecosystem turnovers. Approaches discussed in this study thus provide a vehicle for further studies.

Preliminary assessment of radiological conditions at the Ranger land application area

International Nuclear Information System (INIS)

Kavasnicka, J.; Bywater, J.

1992-01-01

Some 18 GBq of uranium and 1.5 GBq of 226 Ra were disposed of by land application on the designated disposal area by March 1989. This preliminary study, which is part of a longer-term project, outlines the assessment of external gamma radiation exposures from short-lived gamma-ray emitting decay products of 226 Ra and of internal exposures from inhalation of uranium and 226 Ra resuspended from the soil surface. The effective dose equivalent from these two exposure pathways for an adult member of the public was calculated to be about 0.05 mSv.y -1 (based on a 4 hour per day occupancy of the disposal area). This dose implies a total combined load limit of 490 kBq.m -2 of uranium plus 41 kBq.m -2 of 226 Ra. It is expected that the load limit will be reduced when all pathways and more recent data are taken into the account. 8 refs., 14 tabs., 3 figs

Preliminary assessment of an S.G.H.W. type research reactor

International Nuclear Information System (INIS)

Bicevskis, A.; Chapman, A.G.; Hesse, E.W.

1970-08-01

A preliminary design study has been made of a research reactor, based on the enriched S.G.H.W.R. concept, to be used for power reactor fuel irradiation, isotope production, basic research, and training in nuclear technology. A reactor physics assessment established a core size which would allow uninterrupted operation for the required irradiation period consistent with low capital and operating costs. A design was selected with 24 channels, a D 2 O calandria diameter of 2.7 m and an overall core height of 4.0 m. The capital cost was estimated as $750,000 for the fuel and $1,600,000 for the moderator, the refuelling cost being $340,000 per annum. A thermal design study showed that the fission heat of 65 MW could be transmitted to pressurised light water at 200 lb/in 2 abs. and rejected to sea water in two conventional U-tube heat exchangers. The basic design is flexible and can be adapted to meet many special requirements. (author)

Experimental assessment of valve performance in healthy and diseased right ventricular outflow tracts using magnetic resonance velocimetry

Science.gov (United States)

Schiavone, Nicole; Elkins, Christopher; McElhinney, Doff; Eaton, John K.; Marsden, Alison

2017-11-01

Tetralogy of Fallot (ToF), the most common type of cyanotic congenital heart defect, affects 1 in every 2500 newborns annually and typically requires surgical repair of the right ventricular outflow tract (RVOT) and placement of an artificial pulmonary valve. All artificial valves are subject to dysfunction, but their longevity is highly variable. Clinical observation reveals large variations in RVOT anatomy in ToF patients, which may affect longevity. This work aims to experimentally assess the performance of artificial pulmonary valves in anatomically realistic healthy and diseased RVOT geometries using magnetic resonance velocimetry (MRV). With MRV, we can capture 3D, three-component, phase-averaged velocity fields in 3D printed RVOT geometries. The experiment is designed to ensure physiological flow rate and pressure waveforms, while the RVOT geometries are based on anatomies seen clinically in ToF patients. Two models are used in the current work: an idealized RVOT based on healthy subjects aged eleven to thirteen and a diseased geometry with a dilation of 150% in vessel diameter downstream of the pulmonary valve. We will also present preliminary rigid-wall blood flow simulations in each model, towards the ultimate goal of experimental validation of valve simulations.

Optical coherence tomography for diagnosing periodontal disease

Science.gov (United States)

Colston, Bill W., Jr.; Everett, Matthew J.; Da Silva, Luiz B.; Otis, Linda L.; Nathel, Howard

1997-05-01

We have, in this preliminary study, investigated the use of optical coherence tomography for diagnosis of periodontal disease. We took in vitro OCT images of the dental and periodontal tissues from a young pig and compared them to histological sections. These images distinguish tooth and soft tissue relationships that are important in diagnosing and assessing periodontal disease. We have imaged the attachment of gingiva to the tooth surface and located the cemento-enamel junction. This junction is an important reference point for defining attachment level in the diagnosis of periodontal disease. the boundary between enamel and dentin is also visible for most of the length of the anatomical crown, allowing quantitation of enamel thickness and character.

Preliminary biogeochemical assessment of EPICA LGM and Holocene ice samples

Science.gov (United States)

Bulat, S.; Alekhina, I.; Marie, D.; Wagenbach, D.; Raynaud, D.; Petit, J. R.

2009-04-01

weak signals were possible to generate which are now under cloning. The signals were hard to reproduce because of rather low volume of samples. More ice volume is needed to get the biosignal stronger and reproducible. Meantime we are adjusting PCR and in addition testing DNA repair-enzyme cocktail in case of DNA damage. As a preliminary conclusion we would like to highlight the following. Both Holocene and LGM ice samples (EDC99 and EDML) are very clean in terms of Ultra low biomass and Ultra low DOC content. The most basal ice of EDC and EDML ice cores could help in assessing microbial biomass and diversity if present under the glacier at the ice-bedrock boundary. * The present-day consortium includes S. Bulat, I. Alekhina, P. Normand, D. Prieur, J-R. Petit and D. Raynaud (France) and E. Willerslev and J.P. Steffensen (Denmark)

Assessing the burden of medical impoverishment by cause: a systematic breakdown by disease in Ethiopia.

Science.gov (United States)

Verguet, Stéphane; Memirie, Solomon Tessema; Norheim, Ole Frithjof

2016-10-21

Out-of-pocket (OOP) medical expenses often lead to catastrophic expenditure and impoverishment in low- and middle-income countries. Yet, there has been no systematic examination of which specific diseases and conditions (e.g., tuberculosis, cardiovascular disease) drive medical impoverishment, defined as OOP direct medical costs pushing households into poverty. We used a cost and epidemiological model to propose an assessment of the burden of medical impoverishment in Ethiopia, i.e., the number of households crossing a poverty line due to excessive OOP direct medical expenses. We utilized disease-specific mortality estimates from the Global Burden of Disease study, epidemiological and cost inputs from surveys, and secondary data from the literature to produce a count of poverty cases due to OOP direct medical costs per specific condition. In Ethiopia, in 2013, and among 20 leading causes of mortality, we estimated the burden of impoverishment due to OOP direct medical costs to be of about 350,000 poverty cases. The top three causes of medical impoverishment were diarrhea, lower respiratory infections, and road injury, accounting for 75 % of all poverty cases. We present a preliminary attempt for the estimation of the burden of medical impoverishment by cause for high mortality conditions. In Ethiopia, medical impoverishment was notably associated with illness occurrence and health services utilization. Although currently used estimates are sensitive to health services utilization, a systematic breakdown of impoverishment due to OOP direct medical costs by cause can provide important information for the promotion of financial risk protection and equity, and subsequent design of health policies toward universal health coverage, reduction of direct OOP payments, and poverty alleviation.

Pulmonary MR imaging with ultra-short TEs: Utility for disease severity assessment of connective tissue disease patients

International Nuclear Information System (INIS)

Ohno, Yoshiharu; Nishio, Mizuho; Koyama, Hisanobu; Takenaka, Daisuke; Takahashi, Masaya; Yoshikawa, Takeshi; Matsumoto, Sumiaki; Obara, Makoto; Cauteren, Marc van; Sugimura, Kazuro

2013-01-01

Purpose: To evaluate the utility of pulmonary magnetic resonance (MR) imaging with ultra-short echo times (UTEs) at a 3.0 T MR system for pulmonary functional loss and disease severity assessments of connective tissue disease (CTD) patients with interstitial lung disease (ILD). Materials and methods: This prospective study was approved by the institutional review board, and written informed consent was obtained from 18 CTD patients (eight men and ten women) and eight normal subjects with suspected chest disease (three men and five women). All subjects underwent thin-section MDCT, pulmonary MR imaging with UTEs, pulmonary function test and serum KL-6. Regional T2* maps were generated from each MR data set, and mean T2* values were determined from ROI measurements. From each thin-section MDCT data set, CT-based disease severity was evaluated with a visual scoring system. Mean T2* values for normal and CTD subjects were statistically compared by using Student's t-test. To assess capability for pulmonary functional loss and disease severity assessments, mean T2* values were statistically correlated with pulmonary functional parameters, serum KL-6 and CT-based disease severity. Results: Mean T2* values for normal and CTD subjects were significantly different (p = 0.0019) and showed significant correlations with %VC, %DL CO , serum KL-6 and CT-based disease severity of CTD patients (p < 0.05). Conclusion: Pulmonary MR imaging with UTEs is useful for pulmonary functional loss and disease severity assessments of CTD patients with ILD

Pulmonary MR imaging with ultra-short TEs: Utility for disease severity assessment of connective tissue disease patients

Energy Technology Data Exchange (ETDEWEB)

Ohno, Yoshiharu, E-mail: yosirad@kobe-u.ac.jp [Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Nishio, Mizuho [Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Koyama, Hisanobu [Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Takenaka, Daisuke [Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Department of Radiology, Hyogo Cancer Center, Akashi, Hyogo (Japan); Takahashi, Masaya [Advanced Imaging Research Center, Department of Radiology, University of Texas Southwestern Medical Center, Houston, TX (United States); Yoshikawa, Takeshi; Matsumoto, Sumiaki [Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Obara, Makoto; Cauteren, Marc van [Philips Electronics Japan, Tokyo (Japan); Sugimura, Kazuro [Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan)

2013-08-15

Purpose: To evaluate the utility of pulmonary magnetic resonance (MR) imaging with ultra-short echo times (UTEs) at a 3.0 T MR system for pulmonary functional loss and disease severity assessments of connective tissue disease (CTD) patients with interstitial lung disease (ILD). Materials and methods: This prospective study was approved by the institutional review board, and written informed consent was obtained from 18 CTD patients (eight men and ten women) and eight normal subjects with suspected chest disease (three men and five women). All subjects underwent thin-section MDCT, pulmonary MR imaging with UTEs, pulmonary function test and serum KL-6. Regional T2* maps were generated from each MR data set, and mean T2* values were determined from ROI measurements. From each thin-section MDCT data set, CT-based disease severity was evaluated with a visual scoring system. Mean T2* values for normal and CTD subjects were statistically compared by using Student's t-test. To assess capability for pulmonary functional loss and disease severity assessments, mean T2* values were statistically correlated with pulmonary functional parameters, serum KL-6 and CT-based disease severity. Results: Mean T2* values for normal and CTD subjects were significantly different (p = 0.0019) and showed significant correlations with %VC, %DL{sub CO}, serum KL-6 and CT-based disease severity of CTD patients (p < 0.05). Conclusion: Pulmonary MR imaging with UTEs is useful for pulmonary functional loss and disease severity assessments of CTD patients with ILD.

Chagas disease. A new pathophysiological assessment

International Nuclear Information System (INIS)

Redruello, M.; Masoli, O.; Hasson, I.; Cragnolino, D.; Traverso, S.; Perez Balino, N.; Sarmiento, R.; Lazzari, J.; Luluaga, E.

2002-01-01

Background: There is scarce information on myocardial perfusion abnormalities and on the coronary vasomotor condition in Chagas disease patients. Aims: To assess regional perfusion abnormalities and the coronary vasomotor response of patients in the chronic phase of Chagas disease. Methods: With the use of 99mTc-sestamibi SPECT imaging and cold pressor test and intracoronary acetylcoline (ACH) perfusion, we studied 9 patients aged 42,6±12 years, 4 males, in the chronic stage of Chagas disease (5 with the indeterminate form and 4 with heart lesion) with normal coronary arteries. Vasomotor responses to intracoronary increasing doses of ACH and to a single dose of nitroglycerine (NTG) were assessed with digital quantitative angiography. Regional myocardial perfusion was evaluated at rest and after cold pressor test by a semi quantitative score analysis in an 18-segment model with 99mTc-sestamibi SPECT images. Results were expressed as mean ± 2SD. Differences between continuous variables were measured by two tails Student's t test for paired variables and the significance level was set at 5 %. Results: All patients had regional perfusion defects and abnormal vasomotor response. The diameter of the left anterior descending artery decreased 34% from a basal diameter of 3.66∫0.95 mm down to 2.42±0.74 mm after maximal response to ACH (p<0.002). NTG infusion augmented its diameter to 3.86±0.77 mm (p<0.0002) that is a 60% increase from post ACH diameter. Myocardial perfusion score was 1∫2.66 at rest and 6.22±3.6 after cold pressor test (p<0.0001). Conclusions: This group of patients in the chronic phase of Chagas disease showed an abnormal vasoconstrictive response to intracoronary ACH and cold-induced perfusion defects suggesting that endothelial dysfunction plays a role in the pathophysiology of chronic Chagas heart disease

A Preliminary Assessment of Social Vulnerability in Ganga-Brahmaputra-Meghna Delta

Science.gov (United States)

Hazra, Sugata; Islam, Nabiul

2017-04-01

The Ganga-Brahmaputra-Meghna (GBM) Delta has a high population density and is exposed to rapid environmental changes making it one of the most stressed deltas in the world. The low-lying coastal areas of the Ganga-Brahmaputra-Meghna (GBM) Delta comprise 19 coastal districts of Bangladesh and two districts in India with significant land areas within 5 meters of sea level has a population of more than 50 million people at an average population density of 1100 people/km2. This population is exposed to a range of hazards such as severe cyclones, coastal erosion, and salinization, exacerbated by climate change and subsidence which imply severe stress on the resource dependent community of this region. This situation is further complicated by poverty and limited social well-being such as poor access to education/ health/ drinking water/ sanitation facilities, and lack of food and energy security. Thus assessing social vulnerability can help to understand which communities are susceptible to environmental change and guide adaptation actions to address these threats. This preliminary study aims to construct a socio-economic index by assessing the social vulnerability of coastal communities of GBM Delta taking consistent and common secondary data from the Census of India and the Bangladesh Bureau of Statisticsand applyinga Principle Component Analysis(PCA) methodology. Several statistical tests like Kaiser-Meyer-Olkin (KMO) have also been used to assess the appropriateness of using PCA. Among the selected common indicators, five major components are found to explain majority of the total variation of social vulnerability across the delta: (1) poverty, (2) dependency ratio, (3) agriculture dependency, (4) lack of sanitation and (5) existence of mud houses. The most important observation is the existence of a social vulnerability gradient across the coast. In other words, socially marginalised and vulnerable communities are found on the Delta margin in both India and

A Preliminary Assessment of a Deep Borehole disposal of Spent Fuels

International Nuclear Information System (INIS)

Lee, Younmyoung; Jeon, Jongtae

2014-01-01

Deep borehole disposal (DBD) of such radioactive waste as spent nuclear fuels (SFs) and other waste forms has been investigating mainly at Sandia National Labs for the US DOE as an alternative option. DBD can give advantages over less deep geological disposal since the disposal of wastes at a great depth where a low degree of permeability in the potentially steady rock condition will be beneficial for nuclide movement. Groundwater in the deep basement rock can even have salinity and less chance to mix with groundwater above. The DBD concept is quite straightforward and even simple: Waste canisters are simply emplaced in the lower 2 km part of the borehole down to 5 km deep. Through this study, a conceptual DBD is assessed for a similar case as the US DOE's approach, in which 400 SF canisters are to be emplaced at a deep bottom between 3km and 5km depths, upon which an additional 1km-thick compacted bentonite is overbuffered, and the remaining upper part of the borehole is backfilled again with a mixture of crushed rock and bentonite. Then, the total 5km-deep borehole has three zones: a disposal zone at the bottom 2km, a buffer zone at the next 1km, and backfill zone at the rest top 2km, as illustrated conceptually in Fig. 1. To demonstrate the feasibility in view of long-term radiological safety, a rough model for a safety assessment of this conceptual deep borehole repository system, providing detailed models for nuclide transport in and around the geosphere and biosphere under normal nuclide release scenarios that can occur after a closure of the repository, has been developed using GoldSim. A simple preliminary result in terms of the dose exposure rate from a safety assessment of the DBD is also presented and compared to the case of direct disposal of SFs in a KBS-3V vertical type repository, carried out in previous studies. For different types and shapes of repositories at each different depth, direct comparison between a DBD and a KBS-3 type disposal of

A Preliminary Assessment of a Deep Borehole disposal of Spent Fuels

Energy Technology Data Exchange (ETDEWEB)

Lee, Younmyoung; Jeon, Jongtae [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2014-05-15

Deep borehole disposal (DBD) of such radioactive waste as spent nuclear fuels (SFs) and other waste forms has been investigating mainly at Sandia National Labs for the US DOE as an alternative option. DBD can give advantages over less deep geological disposal since the disposal of wastes at a great depth where a low degree of permeability in the potentially steady rock condition will be beneficial for nuclide movement. Groundwater in the deep basement rock can even have salinity and less chance to mix with groundwater above. The DBD concept is quite straightforward and even simple: Waste canisters are simply emplaced in the lower 2 km part of the borehole down to 5 km deep. Through this study, a conceptual DBD is assessed for a similar case as the US DOE's approach, in which 400 SF canisters are to be emplaced at a deep bottom between 3km and 5km depths, upon which an additional 1km-thick compacted bentonite is overbuffered, and the remaining upper part of the borehole is backfilled again with a mixture of crushed rock and bentonite. Then, the total 5km-deep borehole has three zones: a disposal zone at the bottom 2km, a buffer zone at the next 1km, and backfill zone at the rest top 2km, as illustrated conceptually in Fig. 1. To demonstrate the feasibility in view of long-term radiological safety, a rough model for a safety assessment of this conceptual deep borehole repository system, providing detailed models for nuclide transport in and around the geosphere and biosphere under normal nuclide release scenarios that can occur after a closure of the repository, has been developed using GoldSim. A simple preliminary result in terms of the dose exposure rate from a safety assessment of the DBD is also presented and compared to the case of direct disposal of SFs in a KBS-3V vertical type repository, carried out in previous studies. For different types and shapes of repositories at each different depth, direct comparison between a DBD and a KBS-3 type disposal of

Preliminary engineering assessment of the HCLL and HCPB Neutron Activation System

Energy Technology Data Exchange (ETDEWEB)

Calderoni, Pattrick; Leichtle, Dieter [Fusion for Energy, Barcelona, (Spain); Angelone, Maurizio [ENEA, Unita Tecnica Fusione, Frascati, (Italy); Klix, Axel [KIT, Eggenstein-Leopoldshafen, (Germany)

2015-07-01

The Neutron Activation System (NAS) is one of the four types of neutronics sensors considered for the testing of the HCLL and HCPB Test Blanket Module (TBM) in ITER. It measures the absolute neutron flux intensity with information on the neutron spectrum in selected positions of the TBM. The working principle of the NAS is as follows: the system moves small activation probes (capsules) into selected positions in the TBM (irradiation ends) by means of pneumatic transport with pressurized helium gas; the capsules are irradiated for a selected period, depending on their materials composition (several tens of seconds up to the full plasma pulse length); immediately after the irradiation they are extracted and transported to a gamma spectrometer by means of the same pneumatic transport system; the gamma spectrometer determines the induced gamma activity; the neutron flux and neutron fluence is calculated from the measured gamma activity and the known activation cross section of the materials in the activation probe; after the measurement the capsule is sent either to a disposal or storage (for later measurement). This paper summarizes the results of the feasibility assessment of the TBM NAS in the conceptual design phase, including design justification, identification of requirements based on the expected operating conditions in ITER and preliminary engineering assessment of the activation materials, irradiation ends integration in the modules design and the counting station. (authors)

Decentralised wastewater treatment effluent fertigation: preliminary ...

African Journals Online (AJOL)

Decentralised wastewater treatment effluent fertigation: preliminary technical assessment. ... living in informal settlements with the effluent produced being used on agricultural land. ... Banana and taro required 3 514 mm of irrigation effluent.

The economic impact of foot and mouth disease and its control in South-East Asia: a preliminary assessment with special reference to Thailand.

Science.gov (United States)

Perry, B D; Kalpravidh, W; Coleman, P G; Horst, H S; McDermott, J J; Randolph, T F; Gleeson, L J

1999-08-01

A pilot study of the economic impact of foot and mouth disease (FMD) in the countries and region of South-East Asia is described. Previous economic impact assessments are reviewed and summarised and a synthesis of these contributions is constructed. A framework for the future economic impact of the disease is then developed, incorporating analyses at the sectoral (production system), national and regional levels. Data requirements for such studies are also identified. Integrated epidemiological and economic models for impact assessment were developed and applied to the case study country of Thailand. The models were used to evaluate the economic viability of FMD control programmes in the country. Scenarios evaluated include the effect of improving vaccination coverage and thus reducing productivity losses, and the effect of eventual eradication of the disease. The results indicate that economic returns to the high expenditures incurred in FMD control could be achieved in the short term if greater international trade in pork products was made possible and export prices higher than those in the domestic market could be attained. If FMD were to be eradicated from Thailand in 2010, the eradication would be economically viable, even without exports, with a predicted benefit-cost ratio of 3.73. With additional exports, the economic justification for control becomes much stronger with a benefit-cost ratio of up to 15:1 being achieved. If eradication is not achieved until 2020, returns remain positive without exports, but at a lower rate. The authors propose that the integrated epidemiological and economic models developed be applied to other countries of the region to gain a more accurate insight into the future benefits of FMD control and eradication in the region.

Cochlear Implants and Psychiatric Assessments: a Norrie Disease Case Report.

Science.gov (United States)

Jacques, Denis; Dubois, Thomas; Zdanowicz, Nicolas; Gilain, Chantal; Garin, Pierre

2017-09-01

It is important to perform psychiatric assessments of adult patients who are candidates for cochlear implants both to screen them for psychiatric disorders and to assess their understanding and compliance with the procedure. Deafness is a factor of difficulty for conducting in-depth psychiatric interviews, but concomitant blindness may make it impossible. After a description of Norrie disease, a rare disease in which blindness and deafness may occur together, we propose a case report of a patient suffering from the disease and who consulted in view of a cochlear implant. Early information on cochlear implants appears to be necessary before total deafness occurs in patients suffering from Norrie disease. An inventory of digital communication tools that can be used by the patient is also highly valuable. Research should be supported for a more systematic use of psychiatric assessments prior to cochlear implants. In the special case of Norrie disease, we recommend early screening for mental retardation and related psychotic disorders and, depending on the patient's level of understanding, preventive information on the benefits and limits of cochlear implants before total deafness occurs.

Preliminary risk assessment database and risk ranking of pharmaceuticals in the environment

International Nuclear Information System (INIS)

Cooper, Emily R.; Siewicki, Thomas C.; Phillips, Karl

2008-01-01

There is increasing concern about pharmaceuticals entering surface waters and the impacts these compounds may have on aquatic organisms. Many contaminants, including pharmaceuticals, are not completely removed by wastewater treatment. Discharge of effluent into surface waters results in chronic low-concentration exposure of aquatic organisms to these compounds, with unknown impacts. Exposure of virulent bacteria in wastewater to antibiotic residues may also induce resistance, which could threaten human health. The purpose of this study was to provide information on pharmaceutical threats to the environment. A preliminary risk assessment database for common pharmaceuticals was created and put into a web-accessible database named 'Pharmaceuticals in the Environment, Information for Assessing Risk' (PEIAR) to help others evaluate potential risks of pharmaceutical contaminants in the environment. Information from PEIAR was used to prioritize compounds that may threaten the environment, with a focus on marine and estuarine environments. The pharmaceuticals were ranked using five different combinations of physical-chemical and toxicological data, which emphasized different risks. The results of the ranking methods differed in the compounds identified as high risk; however, drugs from the central nervous system, cardiovascular, and anti-infective classes were heavily represented within the top 100 drugs in all rankings. Anti-infectives may pose the greatest overall risk based upon our results using a combination of factors that measure environmental transport, fate, and aquatic toxicity. The dataset is also useful for highlighting information that is still needed to assuredly assess risk

Preliminary parameter assessments of a spiral FFAG accelerator for proton therapy

International Nuclear Information System (INIS)

Smirnov, V.L.; Azaryan, N.S.; Vorozhtsov, S.B.

2013-01-01

Fixed-Field Alternating-Gradient (FFAG) accelerator was invented in the 1950-60s but never progressed beyond the model stage. Starting from 2000, new interest in this type of accelerator arose. Given advantages of the FFAG over the synchrotron, cyclotron and linac, there are many possible applications of the accelerator. Among them, we are mostly interested in acceleration of protons and light ions for hadron therapy. In this connection a preliminary set of parameters of the facility was estimated and, in particular, the magnetic sector shape and corresponding dynamical properties of the magnetic field of the accelerator were calculated. In addition, preliminary considerations about the RF system design are given.

Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-Cog): Normative Data for the Portuguese Population.

Science.gov (United States)

Nogueira, Joana; Freitas, Sandra; Duro, Diana; Tábuas-Pereira, Miguel; Guerreiro, Manuela; Almeida, Jorge; Santana, Isabel

2018-02-28

The Alzheimer's Disease Assessment Scale - Cognitive Subscale is a brief battery developed to assess cognitive functioning in Alzheimer's disease that encompasses the core characteristics of cognitive decline (e.g. memory, language, praxis, constructive ability and orientation). The early detection, as well as the monitoring of cognitive decline along disease progression, is extremely important in clinical care and interventional research. The main goals of the present study were to analyze the psychometric properties of the Portuguese version of the Alzheimer's Disease Assessment Scale - Cognitive Subscale, and to establish normative values for the Portuguese population. The Portuguese version of Alzheimer's Disease Assessment Scale - Cognitive Subscale was administered to 223 cognitively healthy participants according to a standard assessment protocol consisting of the Mini-Mental State Examination, the Montreal Cognitive Assessment and the Adults and Older Adults Functional Assessment Inventory. Normal performance on the assessment protocol was the inclusion criteria for the study. The Alzheimer's Disease Assessment Scale - Cognitive Subscale revealed good psychometric properties when used in the Portuguese population. Age was the main predictor of the Alzheimer's Disease Assessment Scale - Cognitive Subscale total score (R2 = 0.123), whereas the influence of education level was lower (R2 = 0.027). These two variables explained 14.4% of the variance on the Alzheimer's Disease Assessment Scale - Cognitive Subscale scores and were used to stratify the normative values for the Portuguese population presented here. On the total sample, the average total score in the Alzheimer's Disease Assessment Scale - Cognitive Subscale was 6 points. The normative data were determined according to age and educational level as these were the sociodemographic variables that significantly contributed to the prediction of the Alzheimer's Disease Assessment Scale - Cognitive Subscale

[Valvular heart disease: preoperative assessment and postoperative care].

Science.gov (United States)

Nägele, Reto; Kaufmann, Beat A

2013-10-30

Patients with valvular heart disease or with a prosthetic heart valve replacement are seen with increasing frequency in clinical practice. The medical care and evaluation of patients with valvular heart disease before valve surgery, but also the post-operative treatment is complex and managed by general practitioners, cardiologists and cardiac surgeons. In this mini-review we will first discuss the preoperative assessment of the two most common valvulopathies, aortic stenosis and mitral regurgitation. Then we will discuss the post-operative care, which includes the management of anticoagulation, serial follow up and as well as the diagnostic assessment of complications such as thromboembolism, hemolysis, endocarditis and valve dysfunction.

A preliminary assessment of noise level during Deepawali festival in Balasore, India.

Science.gov (United States)

Goswami, Shreerup; Swain, Bijay Kumar; Mohapatra, Hara Prasad; Bal, Kshirod Kumar

2013-11-01

A preliminary assessment of noise levels during Deepawali, was made in the present study. In order to assess the situation of noise levels in and around Balasore during two consecutive Deepawali of the year 2010 and 2011; noise monitoring was carried out in three different specified times (4:30-7:00 p.m., 7:00-10:30 p.m., 10:30 p.m.-1:00 a.m.). Noise descriptors such as L10, L50, L90, Leq, noise pollution level and noise climate were assessed to reveal the extent of noise pollution in this festival of crackers. Permissible limit of noise levels (Leq) prescribed by WHO during the festival was 100 dB and Lmax must not exceed 110 dB during such occasion. However, in all the cases Lmax and NPL values exceeded 110 dB, while Leq values ranged from 92.9 to 101.9 dB during 2010 Deepawali and 81.5 to 100.8 dB during 2011 Deepawali. On the other hand, all the noise monitoring sites belonged to residential areas. The assessed noise levels during such festivity are much more than 55/45 dB i.e. prescribed for residential areas for day/night time by CPCB. However, it was observed that the noise of Deepawali (Leq) decreased considerably and was less during 2011 than 2010. These may be due to increased environmental awareness among the public. Subsequently, the people of Balasore prefered to celebrate Deepawali, the festival of lights without sound and smoke. Noise policy should also be worked out for a better understanding of such local, social and cultural festivals in which annoyance arise.

Lessons learned from the preliminary performance assessment exercise for the Vienne site strategies for investigating the granodiorite confinement capability

International Nuclear Information System (INIS)

Lebon, P.

1999-01-01

One of the three sites under study by ANDRA is located on the Poitou shoal in the Vienne Department. The granitic basement rock is overlain by a 160 m thick layer of Jurassic sediments containing two seasonally pumped aquifers. The preliminary hydrogeological model of the granitic basement assumed that regional flow is SE-NW, and circulates in the hecto-metric fractures, and that groundwater flow velocity is very low. A preliminary performance assessment exercise focusing on the geological barrier was carried out based on these assumptions and a disposal concept where radwaste is stored in separate granodiorite 'blocks' delimited by the water-bearing fractures. As regards of the granodioritic blocks, the programme goals include analysing of detailed structure, obtaining uncontaminated samples of interstitial ground water in order to determine its physicochemical properties and evaluating transport and retention parameters. (author)

Development and initial validation of the Localized Scleroderma Skin Damage Index and Physician Global Assessment of disease Damage: a proof-of-concept study

Science.gov (United States)

Vilaiyuk, Soamarat; Torok, Kathryn S.; Medsger, Thomas A.

2010-01-01

Objective. To develop and assess the psychometric properties of the Localized Scleroderma (LS) Skin Damage Index (LoSDI) and Physician Global Assessment of disease Damage (PGA-D). Methods. Damage was defined as irreversible/persistent changes (>6 months) due to previous active disease/complications of therapy. Eight rheumatologists assessed the importance of 17 variables in formulating the PGA-D/LoSDI. LS patients were evaluated by two rheumatologists using both tools to assess their psychometric properties. LoSDI was calculated by summing three scores for cutaneous features of damage [dermal atrophy (DAT), subcutaneous atrophy (SAT) and dyspigmentation (DP)] measured at 18 anatomic sites. Patient GA of disease severity (PtGA-S), Children's Dermatology Life Quality Index (CDLQI) and PGA-D were recorded at the time of each examination. Results. Thirty LS patients (112 lesions) and nine patient-visit pairs (18 lesions) were included for inter- and intra-rater reliability study. LoSDI and its domains DAT, SAT, DP and PGA-D demonstrated excellent inter- and intra-rater reliability (reliability coefficients 0.86–0.99 and 0.74–0.96, respectively). LoSDI correlated moderately with PGA-D and poorly with PtGA-S and CDLQI. PGA-D correlated moderately with PtGA-S, but poorly with CDLQI. Conclusions. To complete the LS Cutaneous Assessment Tool (LoSCAT), we developed and evaluated the psychometric properties of the LoSDI and PGA-D in addition to the LS Skin Severity Index (LoSSI). These instruments will facilitate evaluation of LS patients for individual patient management and clinical trials. LoSDI and PGA-D demonstrated excellent reliability and high validity. LoSCAT provides an improved understanding of LS natural history. Further study in a larger group of patients is needed to confirm these preliminary findings. PMID:20008472

Preliminary risk assessment of the Integral Inherently-Safe Light Water Reactor

International Nuclear Information System (INIS)

McCarroll, Kellen R.; Lee, John C.; Manera, Annalisa; Memmott, Matthew J.; Ferroni, Paolo

2017-01-01

The Integral, Inherently Safe Light Water Reactor (I 2 S-LWR) concept seeks to significantly increase nuclear power plant safety. The project implements a safety-by-design philosophy, eliminating several initiating events and providing novel, passive safety systems at the conceptual phase. Pursuit of unparalleled safety employs an integrated development process linking design with deterministic and probabilistic safety analyses. Unique aspects of the I 2 S-LWR concept and design process present challenges to the probabilistic risk assessment (PRA), particularly regarding overall flexibility, auditability and resolution of results. Useful approaches to initiating events and conditional failures are presented. To exemplify the risk-informed design process using PRA, a trade-off study of two safety system configurations is presented. Although further optimization is required, preliminary results indicate that the I 2 S-LWR can achieve a core damage frequency (CDF) from internal events less than 1.01 × 10 −8 /ry, including reactor vessel ruptures. Containment bypass frequency due to primary heat exchanger rupture is found to be comparable to non-vessel rupture CDF.

Oxygen-enhanced MRI for patients with connective tissue diseases: Comparison with thin-section CT of capability for pulmonary functional and disease severity assessment

Energy Technology Data Exchange (ETDEWEB)

Ohno, Yoshiharu, E-mail: yosirad@kobe-u.ac.jp [Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Nishio, Mizuho [Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Koyama, Hisanobu [Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Yoshikawa, Takeshi; Matsumoto, Sumiaki [Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Seki, Shinichiro [Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Tsubakimoto, Maho [Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Nakagami-Gun, Okinawa (Japan); Sugimura, Kazuro [Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan)

2014-02-15

Purpose: To prospectively and directly compare oxygen-enhanced (O{sub 2}-enhanced) MRI with thin-section CT for pulmonary functional loss and disease severity assessment in connective tissue disease (CTD) patients with interstitial lung disease (ILD). Materials and methods: Thin-section CT, O{sub 2}-enhanced MRI, pulmonary function test and serum KL-6 were administered to 36 CTD patients with ILD (23 men, 13 women; mean age: 63.9 years) and nine CTD patients without ILD (six men, and three women; mean age: 62.0 years). A relative-enhancement ratio (RER) map was generated from O{sub 2}-enhanced MRI and mean relative enhancement ratio (MRER) for each subject was calculated from all ROI measurements. CT-assessed disease severity was evaluated with a visual scoring system from each of the thin-section CT data. MRER and CT-assessed disease severities of CTD patients with and without ILD were then statistically compared. To assess capability for pulmonary functional loss and disease severity assessment in CTD patients, correlations of MRER and CT-assessed disease severity with pulmonary functional parameters and serum KL-6 in all subjects were statistically determined. Results: MRER and CT-assessed disease severity showed significant differences between CTD patients with (MRER: 0.15 ± 0.08, CT-assessed disease severity: 13.0 ± 7.4%) and without ILD (MRER: 0.25 ± 0.06, p = 0.0011; CT-assessed disease severity: 1.6 ± 1.6%, p < 0.0001). MRER and CT-assessed disease severity correlated significantly with pulmonary functional parameters and serum KL-6 in all subjects (0.61 ≤ r ≤ 0.79, p < 0.05). Conclusion: O{sub 2}-enhanced MRI was found to be as useful as thin-section CT for pulmonary functional loss and disease severity assessment of CTD patients with ILD.

Oxygen-enhanced MRI for patients with connective tissue diseases: Comparison with thin-section CT of capability for pulmonary functional and disease severity assessment

International Nuclear Information System (INIS)

Ohno, Yoshiharu; Nishio, Mizuho; Koyama, Hisanobu; Yoshikawa, Takeshi; Matsumoto, Sumiaki; Seki, Shinichiro; Tsubakimoto, Maho; Sugimura, Kazuro

2014-01-01

Purpose: To prospectively and directly compare oxygen-enhanced (O 2 -enhanced) MRI with thin-section CT for pulmonary functional loss and disease severity assessment in connective tissue disease (CTD) patients with interstitial lung disease (ILD). Materials and methods: Thin-section CT, O 2 -enhanced MRI, pulmonary function test and serum KL-6 were administered to 36 CTD patients with ILD (23 men, 13 women; mean age: 63.9 years) and nine CTD patients without ILD (six men, and three women; mean age: 62.0 years). A relative-enhancement ratio (RER) map was generated from O 2 -enhanced MRI and mean relative enhancement ratio (MRER) for each subject was calculated from all ROI measurements. CT-assessed disease severity was evaluated with a visual scoring system from each of the thin-section CT data. MRER and CT-assessed disease severities of CTD patients with and without ILD were then statistically compared. To assess capability for pulmonary functional loss and disease severity assessment in CTD patients, correlations of MRER and CT-assessed disease severity with pulmonary functional parameters and serum KL-6 in all subjects were statistically determined. Results: MRER and CT-assessed disease severity showed significant differences between CTD patients with (MRER: 0.15 ± 0.08, CT-assessed disease severity: 13.0 ± 7.4%) and without ILD (MRER: 0.25 ± 0.06, p = 0.0011; CT-assessed disease severity: 1.6 ± 1.6%, p < 0.0001). MRER and CT-assessed disease severity correlated significantly with pulmonary functional parameters and serum KL-6 in all subjects (0.61 ≤ r ≤ 0.79, p < 0.05). Conclusion: O 2 -enhanced MRI was found to be as useful as thin-section CT for pulmonary functional loss and disease severity assessment of CTD patients with ILD

Preliminary risk assessment for nuclear waste disposal in space. Volume I. Executive summary of technical report

International Nuclear Information System (INIS)

Rice, E.E.; Denning, R.S.; Friedlander, A.L.

1982-01-01

Three major conclusions come from this preliminary risk assessment of nuclear waste disposal in space. Preliminary estimates of space disposal risk are low, even with the estimated uncertainty bounds. If calculated mined geologic repository (MGR) release risks remain low, and the EPA requirements continue to be met, then no additional space disposal study effort is warranted. If risks perceived by the public are significant in the acceptance of mined geologic repositories, then consideration of space disposal as an MGR complement is warranted. As a result of this study, the following recommendations are made to NASA and the US DOE: During the continued evaluation of the mined geologic repository risk over the years ahead by DOE, if any significant increase in the calculated health risk is predicted for the MGR, then space disposal should be reevaluated at that time. The risks perceived by the public for the MGR should be evaluated on a broad basis by an independent organization to evaluate acceptance. If, in the future, MGR risks are found to be significant due to some presently unknown technical or social factor, and space disposal is selected as an alternative that may be useful in mitigating the risks, then the following space disposal study activities are recommended: improvement in chemical processing technology for wastes; payload accident response analysis; risk uncertainty analysis for both MGR and space disposal; health risk modeling that includes pathway and dose estimates; space disposal cost modeling; assessment of space disposal perceived (by public) risk benefit; and space systems analysis supporting risk and cost modeling

Systematic review: questionnaires for assessment of gastroesophageal reflux disease.

Science.gov (United States)

Bolier, E A; Kessing, B F; Smout, A J; Bredenoord, A J

2015-01-01

Numerous questionnaires with a wide variety of characteristics have been developed for the assessment of gastroesophageal reflux disease (GERD). Four well-defined dimensions are noticeable in these GERD questionnaires, which are symptoms, response to treatment, diagnosis, and burden on the quality of life of GERD patients. The aim of this review is to develop a complete overview of all available questionnaires, categorized per dimension of the assessment of GERD. A systematic search of the literature up to January 2013 using the Pubmed database and the Embase database, and search of references and conference abstract books were conducted. A total number of 65 questionnaires were extracted and evaluated. Thirty-nine questionnaires were found applicable for the assessment of GERD symptoms, three of which are generic gastrointestinal questionnaires. For the assessment of response to treatment, 14 questionnaires were considered applicable. Seven questionnaires with diagnostic purposes were found. In the assessment of quality of life in GERD patients, 18 questionnaires were found and evaluated. Twenty questionnaires were found to be used for more than one assessment dimension, and eight questionnaires were found for GERD assessment in infants and/or children. A wide variety of GERD questionnaires is available, of which the majority is used for assessment of GERD symptoms. Questionnaires differ in aspects such as design, validation and translations. Also, numerous multidimensional questionnaires are available, of which the Reflux Disease Questionnaire is widely applicable. We provided an overview of GERD questionnaires to aid investigators and clinicians in their search for the most appropriate questionnaire for their specific purposes. © 2013 International Society for Diseases of the Esophagus.

Preliminary study on the establishment of the radionuclide declaration methods for radionuclides in LILW radioactive waste

International Nuclear Information System (INIS)

Hwang, K. H.; Lee, K. J.; Jung, C. W.

2003-01-01

The preliminary study on declaration methods has been done for each radionuclide in LILW radwaste drum in Korean NPPs. View from the preliminary establishment of radio nuclide declaration methods, The selection of assessment target nuclide through the qualitative method and preliminary criteria for routine declaration methods in each radio nuclide was derived. First of all, selection criteria and preliminary assessment method for each target radionuclide was surveyed and investigated. And, the selection criteria and selected the target radio nuclides from the basis on criteria was derived. And the preliminary suggestion about the declaration methods for each target radio nuclide was established

Concurrent Multidisciplinary Preliminary Assessment of Space Systems (COMPASS) Final Report: Advanced Long-Life Lander Investigating the Venus Environment (ALIVE)

Science.gov (United States)

Oleson, Steven R.

2018-01-01

The COncurrent Multidisciplinary Preliminary Assessment of Space Systems (COMPASS) Team partnered with the Applied Research Laboratory to perform a NASA Innovative Advanced Concepts (NIAC) Program study to evaluate chemical based power systems for keeping a Venus lander alive (power and cooling) and functional for a period of days. The mission class targeted was either a Discovery ($500M) or New Frontiers ($750M to $780M) class mission.

Magnetic resonance imaging of the brain in neonates. Preliminary results

International Nuclear Information System (INIS)

Dumoulin, M.; Legrand, M.; Gremillet, C.; Lecouffe, P.; Rousseau, J.; Pruvo, J.P.; Marchandise, X.

1991-01-01

The place of neonatal cerebral MRI and its specific contribution compared with conventional imaging techniques were evaluated in 36 patients. The difficulties specific to the patient population studied met during this preliminary period are described, with their local solutions. A preliminary evaluation of the diagnostic and prognostic value of MRI according to the disease state and gestational age is presented. The specific contribution of MRI compared with transfontanellar ultrasonography and CT scan is discussed [fr

Renewable Energy Park - Preliminary Feasibility & Engineering Report

Energy Technology Data Exchange (ETDEWEB)

Ariwite, Roderick [Fallon Paiute Shoshone Tribe, NV (United States)

2015-07-31

This "Renewable Energy Park - Preliminary Feasibility & Engineering Report" seeks to provide an overall assessment and review of renewable energy development opportunities on the Fallon Indian Reservation and Colony Lands.

Contrast-enhanced ultrasonography for the determination of Crohn’s disease activity – preliminary experience

Science.gov (United States)

Białecki, Marcin; Białecka, Agnieszka; Laskowska, Katarzyna; Kłopocka, Maria; Liebert, Ariel; Lemanowicz, Adam; Serafin, Zbigniew

2014-01-01

Summary Background Contrast-enhanced ultrasound (CEUS) is a recent non-invasive modality, which may partially replace currently used techniques (endoscopy, CT enterography and MR enterography) in the diagnostics and assessment of Crohn’s disease (CD). The aim of the study was to analyze early experience in the use of CEUS for the measurement of activity and staging of CD. Material/Methods Eleven patients previously diagnosed with CD were included in the study. They underwent contrast-enhanced ultrasonography (SonoVue, Bracco), low-dose CT enterography (LDCTE), assessment of laboratory markers of inflammation and clinical CD activity index (CDAI). Contrast enhancement was evaluated using a semi-quantitative method and a quantitative method that included measurement of peak enhancement (PE), enhancement curve rise time (RT) and wash-in-rate (WiR). Results Ileal wall thickening was observed in all patients. Semi-quantitative method was used to observe CD activity in CEUS in 10 cases that perfectly matched LDCTE findings. There was a moderate positive correlation between PE and CDAI (r=0.65, p<0.001). There was no significant relationship between perfusion parameters and laboratory markers of inflammation. Conclusions CEUS is a promising modality for non-invasive assessment of pathologic ileal vascularization in the course of Crohn’s disease. Intensity of enhancement in CEUS reflects activity of the disease detected in LDCTE and correlates with CDAI. PMID:24723988

Contrast-enhanced ultrasonography for the determination of Crohn’s disease activity – preliminary experience

International Nuclear Information System (INIS)

Białecki, Marcin; Białecka, Agnieszka; Laskowska, Katarzyna; Kłopocka, Maria; Liebert, Ariel; Lemanowicz, Adam; Serafin, Zbigniew

2014-01-01

Contrast-enhanced ultrasound (CEUS) is a recent non-invasive modality, which may partially replace currently used techniques (endoscopy, CT enterography and MR enterography) in the diagnostics and assessment of Crohn’s disease (CD). The aim of the study was to analyze early experience in the use of CEUS for the measurement of activity and staging of CD. Eleven patients previously diagnosed with CD were included in the study. They underwent contrast-enhanced ultrasonography (SonoVue, Bracco), low-dose CT enterography (LDCTE), assessment of laboratory markers of inflammation and clinical CD activity index (CDAI). Contrast enhancement was evaluated using a semi-quantitative method and a quantitative method that included measurement of peak enhancement (PE), enhancement curve rise time (RT) and wash-in-rate (WiR). Ileal wall thickening was observed in all patients. Semi-quantitative method was used to observe CD activity in CEUS in 10 cases that perfectly matched LDCTE findings. There was a moderate positive correlation between PE and CDAI (r=0.65, p<0.001). There was no significant relationship between perfusion parameters and laboratory markers of inflammation. CEUS is a promising modality for non-invasive assessment of pathologic ileal vascularization in the course of Crohn’s disease. Intensity of enhancement in CEUS reflects activity of the disease detected in LDCTE and correlates with CDAI

Risk assessment for heart disease and workplace ETS exposure among nonsmokers.

OpenAIRE

Steenland, K

1999-01-01

In 1994 the U.S. Occupational Health and Safety Administration (OSHA) published a study of risk assessment for heart disease and lung cancer resulting from workplace exposure to environmental tobacco smoke (ETS) among nonsmokers. This assessment is currently being revised. The present article considers different possible approaches to a risk assessment for heart disease among nonsmokers resulting from workplace ETS exposure, reviews the approach taken by OSHA in 1994, and suggests some modifi...

Assessment of electromagnetic fields intensity emitted by cellular phone base stations in surrounding flats - a preliminary study

International Nuclear Information System (INIS)

Zmyslony, M.; Politanski, P.; Mamrot, P.; Bortkiewicz, A.

2006-01-01

A rapid development of mobile telecommunications (MT) has resulted in an increased concern about possible detrimental health effects of electromagnetic fields (EMFs) emitted by MT systems, and by MT base stations in particular. Research into EMFs effects on the health of inhabitants living in their vicinity requires first of all a solid assessment of the exposure level. Up to now, the reports in this field have been rather scant. This article presents the results of preliminary measurements of EMFs fields in selected flats around selected base stations in the city of Lodz. Measurements of electric field strength, E, to assess EMF exposure were based on the standard procedures currently in force in Poland. As the study is regarded as a preliminary one, the measurements were conducted in buildings with the expected largest radiation. The measurements show that in the flats located up to 500 m from the base station, EMFs are within the limits specified by relevant Polish regulations on the general public and environmental protection. It was also observed that in a few (less than 10%) flats the field with E exceeded 0.8 V/m. The results show that there are no correlations between electric field strength and distance between the flat and the base station. Therefore, the distance from the base station cannot be used to represent the exposure rate; to determine the latter, EMF measurements are necessary. (author)

Effects of energy development on ground water quality: an overview and preliminary assessment

International Nuclear Information System (INIS)

Parker, W.M. III; Yin, S.C.L.; Davis, M.J.; Kutz, W.J.

1981-07-01

A preliminary national overview of the various effects on ground water quality likely to result from energy development. Based on estimates of present and projected energy-development activities, those regions of the country are identified where ground water quality has the potential for being adversely affected. The general causes of change in ground water quality are reviewed. Specific effects on ground water quality of selected energy technologies are discussed, and some case-history material is provided. A brief overview of pertinent legislation relating to the protection and management of ground water quality is presented. Six methodologies that have some value for assessing the potential effects on ground water quality of energy development activities are reviewed. A method of identifying regions in the 48 contiguous states where there is a potential for ground water quality problems is described and then applied

Assessing health-related resiliency in HIV+ Latin women: Preliminary psychometric findings.

Directory of Open Access Journals (Sweden)

Gladys J Jimenez-Torres

Full Text Available HIV-associated vulnerabilities-especially those linked to psychological issues-and limited mental health-treatment resources have the potential to adversely affect the health statuses of individuals. The concept of resilience has been introduced in the literature to shift the emphasis from vulnerability to protective factors. Resilience, however, is an evolving construct and is measured in various ways, though rarely among underserved, minority populations. Herein, we present the preliminary psychometric properties of a sample of HIV-seropositive Puerto Rican women, measured using a newly developed health-related resilience scale.The Resilience Scales for Children and Adolescents, an instrument with solid test construction properties, acted as a model in the development (in both English and Spanish of the HRRS, providing the same dimensions and most of the same subscales. The present sample was nested within the Hispanic-Latino longitudinal cohort of women (HLLC, that is part of the NeuroAIDS Research Program at the University of Puerto Rico (UPR, Medical Sciences Campus (MSC. Forty-five consecutively recruited, HIV+ women from the HLLC completed a demographic survey, the HRRS, and the Beck Depression Inventory-I, Spanish version.The results demonstrate excellent overall internal consistency for the total HRRS score (α = 0.95. Each of the dimensional scores also evidenced acceptable internal consistency (α ≥ 0.88. All the dimensional and subscale content validity indices were above the 0.42 cut-off. Analysis revealed a significant negative correlation between the HRRS total score and BDI-I-S (r(45 = -0.453, p < 0.003.Albeit preliminary in nature, the present study provides support for the HRRS as a measure to assess resilience among individuals living with chronic medical conditions. Minority populations, especially non-English speaking ones, are understudied across the field of medicine, and when efforts are made to include these patient

Quality and Toxicity Assessments of Foot and Mouth Disease Virus ...

African Journals Online (AJOL)

The quality and toxicity assessment of foot and mouth disease virus vaccine was carried out in inoculated guinea pigs. ... could be used for the control and prevention of foot and mouth disease in Nigerian livestock. Keyword: Foot and Mouth Disease ... 2 blended with Incomplete. Seepic Adjuvant (ISA) montanide 206, which.

Natriuretic peptides and integrated risk assessment for cardiovascular disease

DEFF Research Database (Denmark)

Willeit, Peter; Kaptoge, S; Welsh, P.

2016-01-01

samples and collection of data from studies identified through a systematic search of the literature (PubMed, Scientific Citation Index Expanded, and Embase) for articles published up to Sept 4, 2014, using search terms related to natriuretic peptide family members and the primary outcomes......BACKGROUND: Guidelines for primary prevention of cardiovascular diseases focus on prediction of coronary heart disease and stroke. We assessed whether or not measurement of N-terminal-pro-B-type natriuretic peptide (NT-proBNP) concentration could enable a more integrated approach than at present...... by predicting heart failure and enhancing coronary heart disease and stroke risk assessment. METHODS: In this individual-participant-data meta-analysis, we generated and harmonised individual-participant data from relevant prospective studies via both de-novo NT-proBNP concentration measurement of stored...

Preliminary Groundwater Assessment using Electrical Method at Quaternary Deposits Area

Science.gov (United States)

Hazreek, Z. A. M.; Raqib, A. G. A.; Aziman, M.; Azhar, A. T. S.; Khaidir, A. T. M.; Fairus, Y. M.; Rosli, S.; Fakhrurrazi, I. M.; Izzaty, R. A.

2017-08-01

Alternative water sources using groundwater has increasingly demand in recent years. In the past, proper and systematic study of groundwater potential was varies due to several constraints. Conventionally, tube well point was drilled based on subjective judgment of several parties which may lead to the uncertainties of the project success. Hence, this study performed an electrical method to investigate the groundwater potential at quaternary deposits area particularly using resistivity and induced polarization technique. Electrical method was performed using ABEM SAS4000 equipment based on pole dipole array and 2.5 m electrode spacing. Resistivity raw data was analyzed using RES2DINV software. It was found that groundwater was able to be detected based on resistivity and chargeability values which varied at 10 - 100 Ωm and 0 - 1 ms respectively. Moreover, suitable location of tube well was able to be proposed which located at 80 m from the first survey electrode in west direction. Verification of both electrical results with established references has shown some good agreement thus able to convince the result reliability. Hence, the establishment of electrical method in preliminary groundwater assessment was able to assist several parties in term groundwater prospective at study area which efficient in term of cost, time, data coverage and sustainability.

Preliminary results on response assessment using 68Ga-HBED-CC-PSMA PET/CT in patients with metastatic prostate cancer undergoing docetaxel chemotherapy

International Nuclear Information System (INIS)

Seitz, Anna Katharina; Rauscher, Isabel; Kroenke, Markus; Schwaiger, Markus; Haller, Bernhard; Luther, Sophia; Heck, Matthias M.; Horn, Thomas; Gschwend, Juergen E.; Maurer, Tobias; Eiber, Matthias

2018-01-01

results corresponded in seven of 12 patients (58%, 28% to 85%). Our preliminary results suggest that 68 Ga-PSMA PET might be a promising method for treatment response assessment in mCSPC and mCRPC. The data indicate that for different metastatic sites, the performance of 68 Ga-PSMA PET in response assessment might be superior to that of the conventional CT approach and could help differentiate between progressive disease and treatment response. Because of the limited number of patients, the differences revealed in our study were not statistically significant. Thus larger and prospective studies are clearly needed and warranted to confirm the value of 68 Ga-PSMA PET as an imaging biomarker for response assessment. (orig.)

Assessment of airway lesion in obstructive lung diseases by CT

International Nuclear Information System (INIS)

Niimi, Akio; Matsumoto, Hisako; Ueda, Tetsuya; Mishima, Michiaki

2002-01-01

Airway lesion in obstructive pulmonary diseases, such as asthma or chronic obstructive pulmonary disease (COPD), has recently been assessed quantitatively. Especially in asthma, wall thickening of central airways, and its relation to the severity of disease or airflow obstruction has been clarified. Pathophysiologic importance of peripheral airway lesion has also been highlighted by pathologic or physiologic studies. However, direct evaluation of peripheral airway lesion is beyond resolutional limitation of CT. To assess airway trapping, an indirect CT finding of peripheral airway disease, by quantitative and semiquantitative measures and compare them with clinical indices such as pulmonary function, airway responsiveness, or airway inflammation. Patients with stable asthma (n=20) were studied. HRCT at 3 levels of both lungs were scanned. Low attenuation area (LAA)% and mean lung density were quantitatively assessed by an automatic method. Distribution of mosaic pattern was visually scored semiquantitatively. LAA% and mean lung density at full expiratory phase correlated with the degree of airflow obstruction. Mosaic score at full inspiratory phase correlated with the severity of disease and airflow obstruction. Expiratory/inspiratory ratio of mean lung density was also associated with airway responsiveness or residual volume/total lung capacity (RV/TLC). These CT findings may be useful as markers of asthma pathophysiology. (author)

Preliminary Assessment of the Flow of Used Electronics, In ...

Science.gov (United States)

Electronic waste (e-waste) is the largest growing municipal waste stream in the United States. The improper disposal of e-waste has environmental, economic, and social impacts, thus there is a need for sustainable stewardship of electronics. EPA/ORD has been working to improve our understanding of the quantity and flow of electronic devices from initial purchase to final disposition. Understanding the pathways of used electronics from the consumer to their final disposition would provide insight to decision makers about their impacts and support efforts to encourage improvements in policy, technology, and beneficial use. This report is the first stage of study of EPA/ORD's efforts to understand the flows of used electronics and e-waste by reviewing the regulatory programs for the selected states and identifying the key lessons learned and best practices that have emerged since their inception. Additionally, a proof-of-concept e-waste flow model has been developed to provide estimates of the quantity of e-waste generated annually at the national level, as well as for selected states. This report documents a preliminary assessment of available data and development of the model that can be used as a starting point to estimate domestic flows of used electronics from generation, to collection and reuse, to final disposition. The electronics waste flow model can estimate the amount of electronic products entering the EOL management phase based on unit sales dat

Preliminary evaluation of SensHand V1 in assessing motor skills performance in Parkinson disease.

Science.gov (United States)

Cavallo, Filippo; Esposito, Dario; Rovini, Erika; Aquilano, Michela; Carrozza, Maria Chiara; Dario, Paolo; Maremmani, Carlo; Bongioanni, Paolo

2013-06-01

Nowadays, the increasing old population 65+ as well as the pace imposed by work activities lead to a high number of people that have particular injuries for limbs. In addition to persistent or temporary disabilities related to accidental injuries we must take into account that part of the population suffers from motor deficits of the hands due to stroke or diseases of various clinical nature. The most recurrent technological solutions to measure the rehabilitation or skill motor performance of the hand are glove-based devices, able to faithfully capture the movements of the hand and fingers. This paper presents a system for hand motion analysis based on 9-axis complete inertial modules and dedicated microcontroller which are fixed on fingers and forearm. The technological solution presented is able to track the patients' hand motions in real-time and then to send data through wireless communication reducing the clutter and the disadvantages of a glove equipped with sensors through a different technological structure. The device proposed has been tested in the study of Parkinson's disease.

Development of a disease-specific quality of life questionnaire in Addison's disease.

Science.gov (United States)

Løvås, Kristian; Curran, Suzanne; Oksnes, Marianne; Husebye, Eystein S; Huppert, Felicia A; Chatterjee, V Krishna K

2010-02-01

Patients with Addison's disease reproducibly self-report impairment in specific dimensions of general well-being questionnaires, suggesting particular deficiencies in health-related quality-of-life (HRQoL). We sought to develop an Addison's disease-specific questionnaire (AddiQoL) that could better quantify altered well-being and treatment effects. Design, Setting, Patients, Intervention, and Outcomes: We reviewed the literature to identify HRQoL issues in Addison's disease and interviewed patients and their partners in-depth to explore various symptom domains. A list of items was generated, and nine expert clinicians and five expert patients assessed the list for impact and clarity. A preliminary questionnaire was presented to 100 Addison's outpatients; the number of items was reduced after analysis of the distribution of the responses. The final questionnaire responses were assessed by Cronbach's alpha and Rasch analysis. Published studies of HRQoL in Addison's disease indicated reduced vitality and general health perception and limitations in physical and emotional functioning. In-depth interviews of 14 patients and seven partners emphasized the impact of the disease on the emotional domain. Seventy HRQoL items were generated; after the expert consultation process and pretesting in 100 patients, the number of items was reduced to 36. Eighty-six patients completed the final questionnaire; the responses showed high internal consistency with Cronbach's alpha 0.95 and Person Separation Index 0.94 (Rasch analysis). We envisage AddiQoL having utility in trials of hormone replacement and management of patients with Addison's disease, analogous to similar questionnaires in GH deficiency (AGHDA) and acromegaly (AcroQoL).

Disease Risk Assessments Involving Companion Animals: an Overview for 15 Selected Pathogens Taking a European Perspective.

Science.gov (United States)

Rijks, J M; Cito, F; Cunningham, A A; Rantsios, A T; Giovannini, A

2016-07-01

, indicating a clear knowledge gap. There were not enough assessments for any of the 15 diseases to allow meta-analyses, whether these assessments dealt with companion animal disease risk or companion animal-associated human disease risk. Important method and technology gaps were the lack of harmonization in the case definitions used for a given disease and the lack of good diagnostics allowing pathogen identification to taxonomic levels that are meaningful for risk analysis. Molecular epidemiology studies on zoonotic pathogens, which included companion animals among the potential human risk factors, were not found, although such studies would provide good preliminary insights without requiring any tracing of people or any interviews. In addition to performing further risk studies that take into account these issues, there is a need for responsible pet ownership and continued education of professionals in companion animal zoonoses. Additional risk assessment studies should allow more targeted actions to reduce the risk of zoonotic diseases transferred via companion animals and provide information that will promote risk-awareness in healthy human-animal relationships. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Comparison of Disease Activity Score in 28 joints with ESR (DAS28), Clinical Disease Activity Index (CDAI), Health Assessment Questionnaire Disability Index (HAQ-DI) & Routine Assessment of Patient Index Data with 3 measures (RAPID3) for assessing disease activity in patients with rheumatoid arthritis at initial presentation.

Science.gov (United States)

Kumar, B Siddhartha; Suneetha, P; Mohan, Alladi; Kumar, D Prabath; Sarma, K V S

2017-11-01

In patients with rheumatoid arthritis (RA), disease severity assessment is done using Disease Activity Score in 28 joints with ESR (DAS28). Computing DAS28 is time-consuming, requires laboratory testing and an online calculator. There is a need to validate rapid methods of disease severity assessment for routine daily use. This study was conducted to compare DAS28, Clinical Disease Activity Index (CDAI), Health Assessment Questionnaire Disability Index (HAQ-DI) and Routine Assessment of Patient Index Data with 3 measures (RAPID3) to assess the disease activity in patients with RA. We prospectively studied the utility of CDAI, HAQ-DI and RAPID3 scoring in 100 consecutive newly diagnosed, disease modifying antirheumatic drugs (DMARDs) naïve adult patients with RA seen during January 2013 and June 2014 at a tertiary care teaching hospital in south India. The mean age of the patients was 42.1±11.6 yr, there were 82 females. The median [interquartile range (IQR)] symptom duration was 6 (range 4-12) months. The median (IQR) DAS28, CDAI, HAQ-DI and RAPID3 scores at presentation were 7 (6-7), 36 (28-43), 2 (1-2) and 17 (13-19), respectively. A significant positive correlation was observed between DAS28 and CDAI (r=0.568; Pfair' agreement was observed in between DAS28 and CDAI (kappa-statistic=0.296). The agreement between DAS28 and HAQ-DI (kappa-statistic=0.007) and RAPID3 (kappa-statistic=0.072) was less robust. In adult patients with RA, in the setting where illiteracy is high, CDAI emerged as the preferred choice for rapid assessment of severity of disease at the time of initial presentation.

Preliminary Screening Assessment of the Potential Impact of the Phosphate Fertilizer Industry on Wildlife

Energy Technology Data Exchange (ETDEWEB)

Vandenhove, Hildegarde; Sweeck, Lieve; Vives i Batlle, Jordi [SCK.CEN, Belgian Nuclear Research Centre, Boeretang 200, B-2400 Mol (Belgium)

2014-07-01

The activities of the phosphate industry may lead to enhanced levels of naturally occurring radioactivity in terrestrial and freshwater ecosystems. We here perform a preliminary environmental risk assessment (ERA) of the activities of the phosphate industry (phosphate ore mining, phosphate fertilizer factories, phosphate export platforms). We evaluated the environmental impact of 5 phosphate fertilizer plants (located in Belgium, Spain, Syria, Egypt, Brazil) and one phosphate-mine and phosphate-export platforms in the harbour(both located in Syria). These sites were selected because of the enhanced concentrations of naturally occurring radionuclides in the surrounding environments. The ERICA non-human biota assessment tool was used to predict radiation dose rates to the reference organisms and associated risks. Reference organisms were those assigned as default by the ERICA Tool. Potential impact is expressed as a risk quotient (RQ) based on a radiation screening value of 10 μGy h{sup -1}. If RQ ≤ 1, the environment is unlikely at risk and further radiological assessment is deemed not to be required. For all the cases assessed, RQ exceeded 1 for at least one of the reference organisms. {sup 226}Ra or {sup 210}Po were generally the highest contributors to the dose. The aquatic ecosystems in the vicinity of the phosphate fertilizer plants in Tessenderlo (Belgium), Huelva (Spain), Goias (Brazil) and the terrestrial environment around the phosphate mine in Palmyra (Syria) are the ecosystems predicted most at risk. (authors)

Visual Assessment on Coastal Cruise Tourism: A Preliminary Planning Using Importance Performance Analysis

Science.gov (United States)

Trisutomo, S.

2017-07-01

Importance-Performance Analysis (IPA) has been widely applied in many cases. In this research, IPA was applied to measure perceive on coastal tourism objects and its possibility to be developed as coastal cruise tourism in Makassar. Three objects, i.e. Akkarena recreational site, Losari public space at waterfront, and Paotere traditional Phinisi ships port, were selected and assessed visually from water area by a group of purposive resource persons. The importance and performance of 10 attributes of each site were scored using Likert scale from 1 to 5. Data were processed by SPSS-21 than resulted Cartesian graph which the scores were divided in four quadrants: Quadrant I concentric here, Quadrant II keep up the good work, Quadrant III low priority, and Quadrant IV possible overkill. The attributes in each quadrant could be considered as the platform for preliminary planning of coastal cruise tour in Makassar

Preliminary Assessment of Detection Efficiency for the Geostationary Lightning Mapper Using Intercomparisons with Ground-Based Systems

Science.gov (United States)

Bateman, Monte; Mach, Douglas; Blakeslee, Richard J.; Koshak, William

2018-01-01

As part of the calibration/validation (cal/val) effort for the Geostationary Lightning Mapper (GLM) on GOES-16, we need to assess instrument performance (detection efficiency and accuracy). One major effort is to calculate the detection efficiency of GLM by comparing to multiple ground-based systems. These comparisons will be done pair-wise between GLM and each other source. A complication in this process is that the ground-based systems sense different properties of the lightning signal than does GLM (e.g., RF vs. optical). Also, each system has a different time and space resolution and accuracy. Preliminary results indicate that GLM is performing at or above its specification.

Preliminary Assessment of Spatial Competition in the Market for E85

Energy Technology Data Exchange (ETDEWEB)

Bentley Clinton

2017-02-01

The Preliminary Assessment of Spatial Competition in the Market for E85 presentation and supplementary report from the U.S. Department of Energy’s National Renewable Energy Laboratory examine how the spacing of E85 fueling stations impacts E85 retail pricing. The analysis finds an inverse correlation between station density and E85 prices, with local competition putting downward pressure on E85 prices. A gas station with E85 whose nearest competitor is within a 0.5 mile radius is associated with a lower E85 price per gallon than an otherwise identical station with E85 whose nearest competitor is farther away. The analysis also finds a higher level of correlation between E85 and both E10 and wholesale gasoline prices than with ethanol costs. This indicates that E85 may, in fact, be priced with respect to its substitute fuel, and not based on the cost of its inputs. These findings help identify key trends and barriers in E85 markets and highlight data gaps that, if addressed, could help enable competitive E85 markets. The analysis was released in February 2017 and uses national and Minnesota-specific price data.

The prevalence of asthma work relatedness: Preliminary data

Directory of Open Access Journals (Sweden)

Wojciech Dudek

2015-12-01

Full Text Available Objectives: About 5–10% of asthmatics do not respond well to standard treatment plan. Occupational exposure may be one of the factors that can be linked with treatment failure. The aim of the study was to assess the prevalence of work-related asthma (WRA among adult asthmatics under follow up in an outpatient allergy clinic and to create a useful tool for detecting individuals with possible WRA. Material and Methods: Preliminary 5-question questionnaire designed to recognize WRA was presented to 300 asthmatics. All patients with positive preliminary verification along with 50 subjects from control group were asked to fill up a detailed questionnaire. The WRA was diagnosed by positive match for asthma symptoms in combination with workplace exposure indicated in the detailed WRA questionnaire followed by confirmation of each WRA case by detailed exposure analysis. Results: Work-related asthma was recognized in 63 subjects (21% of study group. The preliminary questionnaire has 76.9% sensitivity and 94% specificity in recognition of WRA. Occupational exposure to irritants is a risk factor of WRA recognition (relative risk (RR = 2.09 (1.44:3.03. Working in exposure-free environment is a factor against WRA recognition (RR = 0.38 (0.24:0.61. Among subjects with work-related asthma, the uncontrolled course of the disease is significantly more frequent (p = 0.012. Subjects with WRA more often report sickness absenteeism due to asthma than those without WRA (9.6% vs. 3.2%, respectively, but the observed differences did not reach the statistical significance. Conclusions: Short 5-question questionnaire seems to be a promising tool to detect individuals with possible work-related asthma in the outpatient setting for further evaluation and additional attention.

Preliminary assessment of valve IST effectiveness

International Nuclear Information System (INIS)

Grove, E.; DiBiasio, A.; Carbonaro, J.

1994-01-01

A preliminary review of inservice testing effectiveness for Code Class 1,2, and 3 valves at nuclear power plants was performed. These requirements are specified by the American Society of Mechanical Engineers Boiler and Pressure Vessel Code, Section XI, and the Operations and Maintenance Standard. The Institute of Nuclear Power Operations Nuclear Plant Reliability Data System (NPRDS) database was used to provide failure reports for these components for 1988 to 1992. This time period coincides with the issuance of Generic Letter 89-04, which resulted in a more consistent application of the requirements by the licensees. For this time period, 8,593 valve failures were identified. From the review of the NPRDS database, the primary failure causes and failure modes for motor-operated valves (MOV), air-operated valves (AOV), and check valves (CV) were identified. Solenoid-operated valves were not reviewed in this study. Plant testing programs were effective in identifying approximately 60% of the CV failures, 46% of the AOV failures, and 44% of the MOV failures

Preliminary Validation of a Parent-Child Relational Framework for Teaching Developmental Assessment to Pediatric Residents.

Science.gov (United States)

Regalado, Michael; Schneiderman, Janet U; Duan, Lei; Ragusa, Gisele

A parent-child relational framework was used as a method to train pediatric residents in basic knowledge and observation skills for the assessment of child development. Components of the training framework and its preliminary validation as an alternative to milestone-based approaches are described. Pediatric residents were trained during a 4-week clinical rotation to use a semistructured interview and observe parent-child behavior during health visits using clinical criteria for historical information and observed behavior that reflect developmental change in the parent-child relationship. Clinical impressions of concern versus no concern for developmental delay were derived from parent-child relational criteria and the physical examination. A chart review yielded 330 preterm infants evaluated using this methodology at 4 and 15 months corrected age who also had standardized developmental testing at 6 and 18 months corrected age. Sensitivities and specificities were computed to examine the validity of the clinical assessment compared with standardized testing. A subset of residents who completed 50 or more assessments during the rotation was timed at the end of 4 weeks. Parent-child behavioral markers elicited from the history and/or observed during the health visit correlated highly with standardized developmental assessment. Sensitivities and specificities were 0.72/0.98 and 0.87/0.96 at 4 to 6 and 15 to 18 months, respectively. Residents completed their assessments parent-child relational framework is a potentially efficient and effective approach to training residents in the clinical knowledge and skills of child development assessment. Copyright © 2016 Academic Pediatric Association. Published by Elsevier Inc. All rights reserved.

Preliminary Development of Regulatory PSA Models for SFR

International Nuclear Information System (INIS)

Choi, Yong Won; Shin, Andong; Bae, Moohoon; Suh, Namduk; Lee, Yong Suk

2013-01-01

Well developed PRA methodology exists for LWR (Light Water Reactor) and PHWR (Pressurized Heavy Water Reactor). Since KAERI is developing a prototype SFR targeting to apply for a license by 2017, KINS needs to have a PRA models to assess the safety of this prototype reactor. The purpose of this study is to develop the regulatory PSA models for the independent verification of the SFR safety. Since the design of the prototype SFR is not mature yet, we have tried to develop the preliminary models based on the design data of KAERI's previous SFR design. In this study, the preliminary initiating events of level 1 internal event for SFR were selected through reviews of existing PRA (LWR, PRISM, ASTRID and KALIMER-600) models. Then, the event tree for each selected initiating event was developed. The regulatory PRA models of SFR developed are preliminary in a sense, because the prototype SFR design is not mature and provided yet. Still it might be utilized for the forthcoming licensing review in assessing the risk of safety issues and the configuration control of the design

Mucosal CCR1 gene expression as a marker of molecular activity in Crohn's disease: preliminary data.

Science.gov (United States)

Dobre, Maria; Mănuc, Teodora Ecaterina; Milanesi, Elena; Pleşea, Iancu Emil; Ţieranu, Eugen Nicolae; Popa, Caterina; Mănuc, Mircea; Preda, Carmen Monica; Ţieranu, Ioana; Diculescu, Mihai Mircea; Ionescu, Elena Mirela; Becheanu, Gabriel

2017-01-01

A series of mechanisms of immune response, inflammation and apoptosis have been demonstrated to contribute to the appearance and evolution of Crohn's disease (CD) through the overexpression of several cytokines and chemokines in a susceptible host. The aim of this study was to identify the differences in gene expression profiles analyzing a panel of candidate genes in the mucosa from patients with active CD (CD-A), patients in remission (CD-R), and normal controls. Nine individuals were enrolled in the study: six CD patients (three with active lesions, three with mucosal healing) and three controls without inflammatory bowel disease (IBD) seen on endoscopy. All the individuals underwent mucosal biopsy during colonoscopy. Gene expression levels of 84 genes previously associated with CD were evaluated by polymerase chain reaction (PCR) array. Ten genes out of 84 were found significantly differentially expressed in CD-A (CCL11, CCL25, DEFA5, GCG, IL17A, LCN2, REG1A, STAT3, MUC1, CCR1) and eight genes in CD-R (CASP1, IL23A, STAT1, STAT3, TNF, CCR1, CCL5, and HSP90B1) when compared to controls. A quantitative gene expression analysis revealed that CCR1 gene was more expressed in CD-A than in CD-R. Our data suggest that CCR1 gene may be a putative marker of molecular activity of Crohn's disease. Following these preliminary data, a confirmation in larger cohort studies could represent a useful method in order to identify new therapeutic targets.

Validity of Montreal Cognitive Assessment in non-english speaking patients with Parkinson's disease.

Science.gov (United States)

Krishnan, Syam; Justus, Sunitha; Meluveettil, Radhamani; Menon, Ramshekhar N; Sarma, Sankara P; Kishore, Asha

2015-01-01

The Montreal Cognitive Assessment is a brief and easy screening tool for accurately testing cognitive dysfunction in Parkinson's disease. We tested its validity for use in non-English (Malayalam) speaking patients with Parkinson's disease. We developed a Malayalam (a south-Indian language) version of Montreal Cognitive Assessment and applied to 70 patients with Parkinson's disease and 60 age- and education-matched healthy controls. Metric properties were assessed, and the scores were compared with the performance in validated Malayalam versions of Mini Mental Status Examination and Addenbrooke's Cognitive Examination. The Montreal Cognitive Assessment-Malayalam showed good internal consistency and test-retest reliability and its scores correlated with Mini Mental Status Examination (patients: R = 0.70; P speaking Parkinson's disease patients for early screening and potential future interventions for cognitive dysfunction.

Preliminary analysis of alternative fuel cycles for proliferation evaluation

Energy Technology Data Exchange (ETDEWEB)

Steindler, M. J.; Ripfel, H. C.F.; Rainey, R. H.

1977-01-01

The ERDA Division of Nuclear Research and Applications proposed 67 nuclear fuel cycles for assessment as to their nonproliferation potential. The object of the assessment was to determine which fuel cycles pose inherently low risk for nuclear weapon proliferation while retaining the major benefits of nuclear energy. This report is a preliminary analysis of these fuel cycles to develop the fuel-recycle data that will complement reactor data, environmental data, and political considerations, which must be included in the overall evaluation. This report presents the preliminary evaluations from ANL, HEDL, ORNL, and SRL and is the basis for a continuing in-depth study. (DLC)

EPA Releases Neonicotinoid Assessments for Public Comment

Science.gov (United States)

Release of preliminary ecological and human health risk assessments for the neonicotinoid insecticides clothianidin, thiamethoxam, and dinotefuran, and a preliminary ecological risk assessment for imidacloprid, assessing risks to birds,mammals, non-target

Preliminary study of the application of transthoracic echocardiography-guided three-dimensional printing for the assessment of structural heart disease.

Science.gov (United States)

Zhu, Yanbo; Liu, Jianshi; Wang, Lianqun; Guan, Xin; Luo, Yongjuan; Geng, Jie; Geng, Qingguo; Lin, Yunjia; Zhang, Lixia; Li, Xixue; Lu, Yaping

2017-12-01

To investigate the feasibility and diagnostic value of a preoperative transthoracic echocardiography-guided three-dimensional printed model (TTE-guided 3DPM) for the assessment of structural heart disease (SHD). Fourty-four patients underwent cardiac surgery at Tianjin Chest Hospital. The patients were preoperatively assessed using TTE-guided 3DPM, which was compared to conventional three-dimensional transthoracic echocardiography (3DTTE) along with direct intraoperative findings, which were considered the "gold standard." Twelve patients had SHD, including four with mitral prolapse, two with partial endocardial cushion defects, two with secondary atrial septal defects, two with rheumatic mitral stenosis, one with tetralogy of Fallot, and one with a ventricular septal defect (VSD). Thirty-two patients who did not have SHDs were designated as the negative control group. The sensitivity and specificity of the TTE-guided 3DPM were greater than or equal to those of the 3DTTE. The P-value of the McNemar test of 3DTTE was >.05, which indicates that the difference was not statistically significant (Kappa = 0.745, P guided 3DPM was >.05, which indicates that the difference was not statistically significant (Kappa = 0.955, P guided 3DPM resulted in a P-value >.05, which indicates that the difference was not statistically significant (Kappa = 0.879, P guided 3DPM displayed the 3D structure of SHDs and cardiac lesions clearly and was consistent with the intra-operative findings. Transthoracic echocardiography-guided three-dimensional printed model (TTE-guided 3DPM) provides essential information for preoperative evaluation and decision making for patients with SHDs. © 2017, Wiley Periodicals, Inc.

Preliminary performance assessment for the Waste Isolation Pilot Plant, December 1992. Vol. 1: Third comparison with 40 CFR 191, Subpart B

Energy Technology Data Exchange (ETDEWEB)

NONE

1992-12-15

Before disposing of transuranic radioactive wastes in the Waste Isolation Pilot Plant (WIPP), the United States Department of Energy (DOE) must evaluate compliance with applicable long-term regulations of the United States Environmental Protection Agency (EPA). Sandia National Laboratories is conducting iterative performance assessments of the WIPP for the DOE to provide interim guidance while preparing for final compliance evaluations. This volume contains an overview of WIPP performance assessment and a preliminary comparison with the long-term requirements of the Environmental Radiation Protection Standards for Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes (40 CFR 191, Subpart B). Detailed information about the technical basis for the preliminary comparison is contained in Volume 2. The reference data base and values for input parameters used in the modeling system are contained in Volume 3. Uncertainty and sensitivity analyses related to 40 CFR 191B are contained in Volume 4. Volume 5 contains uncertainty and sensitivity analyses of gas and brine migration for undisturbed performance. Finally, guidance derived from the entire 1992 performance assessment is presented in Volume 6. Results of the 1992 performance assessment are preliminary, and are not suitable for final comparison with 40 CFR 191, Subpart B. Portions of the modeling system and the data base remain incomplete, and the level of confidence in the performance estimates is not sufficient for a defensible compliance evaluation. Results are, however, suitable for providing guidance to the WIPP Project. All results are conditional on the models and data used, and are presented for preliminary comparison to the Containment Requirements of 40 CFR 191, Subpart B as mean complementary cumulative distribution functions (CCDFs) displaying estimated probabilistic releases of radionuclides to the accessible environment. Results compare three conceptual models for

Preliminary performance assessment for the Waste Isolation Pilot Plant, December 1992. Vol. 1: Third comparison with 40 CFR 191, Subpart B

International Nuclear Information System (INIS)

1992-12-01

Before disposing of transuranic radioactive wastes in the Waste Isolation Pilot Plant (WIPP), the United States Department of Energy (DOE) must evaluate compliance with applicable long-term regulations of the United States Environmental Protection Agency (EPA). Sandia National Laboratories is conducting iterative performance assessments of the WIPP for the DOE to provide interim guidance while preparing for final compliance evaluations. This volume contains an overview of WIPP performance assessment and a preliminary comparison with the long-term requirements of the Environmental Radiation Protection Standards for Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes (40 CFR 191, Subpart B). Detailed information about the technical basis for the preliminary comparison is contained in Volume 2. The reference data base and values for input parameters used in the modeling system are contained in Volume 3. Uncertainty and sensitivity analyses related to 40 CFR 191B are contained in Volume 4. Volume 5 contains uncertainty and sensitivity analyses of gas and brine migration for undisturbed performance. Finally, guidance derived from the entire 1992 performance assessment is presented in Volume 6. Results of the 1992 performance assessment are preliminary, and are not suitable for final comparison with 40 CFR 191, Subpart B. Portions of the modeling system and the data base remain incomplete, and the level of confidence in the performance estimates is not sufficient for a defensible compliance evaluation. Results are, however, suitable for providing guidance to the WIPP Project. All results are conditional on the models and data used, and are presented for preliminary comparison to the Containment Requirements of 40 CFR 191, Subpart B as mean complementary cumulative distribution functions (CCDFs) displaying estimated probabilistic releases of radionuclides to the accessible environment. Results compare three conceptual models for

For a General Theory of Health: preliminary epistemological and anthropological notes

Directory of Open Access Journals (Sweden)

Naomar de Almeida Filho

Full Text Available In order to conduct a preliminary evaluation of the conditions allowing for a General Theory of Health, the author explores two important structural dimensions of the scientific health field: the socio-anthropological dimension and the epistemological dimension. As a preliminary semantic framework, he adopts the following definitions in English and Portuguese for two series of meanings: disease = patologia, disorder = transtorno, illness = enfermidade, sickness = doença, and malady = moléstia. He begins by discussing some sociological theories and biomedical concepts of health-disease, which, despite their limitations, can be used as a point of departure for this undertaking, given the dialectical and multidimensional nature of the disease-illness-sickness complex (DIS. Second, he presents and evaluates some underlying socio-anthropological theories of disease, taking advantage of the opportunity to highlight the semeiologic treatment of health-disease through the theory of "signs, meanings, and health practices". Third, he analyzes several epistemological issues relating to the Health theme, seeking to justify its status as a scientific object. Finally, the author focuses the discussion on a proposal to systematize various health concepts as an initial stage for the theoretical construction of the Collective Health field.

For a General Theory of Health: preliminary epistemological and anthropological notes

Directory of Open Access Journals (Sweden)

Almeida Filho Naomar de

2001-01-01

Full Text Available In order to conduct a preliminary evaluation of the conditions allowing for a General Theory of Health, the author explores two important structural dimensions of the scientific health field: the socio-anthropological dimension and the epistemological dimension. As a preliminary semantic framework, he adopts the following definitions in English and Portuguese for two series of meanings: disease = patologia, disorder = transtorno, illness = enfermidade, sickness = doença, and malady = moléstia. He begins by discussing some sociological theories and biomedical concepts of health-disease, which, despite their limitations, can be used as a point of departure for this undertaking, given the dialectical and multidimensional nature of the disease-illness-sickness complex (DIS. Second, he presents and evaluates some underlying socio-anthropological theories of disease, taking advantage of the opportunity to highlight the semeiologic treatment of health-disease through the theory of "signs, meanings, and health practices". Third, he analyzes several epistemological issues relating to the Health theme, seeking to justify its status as a scientific object. Finally, the author focuses the discussion on a proposal to systematize various health concepts as an initial stage for the theoretical construction of the Collective Health field.

Effects of robotic treadmill training on functional mobility, walking capacity, motor symptoms and quality of life in ambulatory patients with Parkinson's disease: a preliminary prospective longitudinal study.

Science.gov (United States)

Paker, Nurdan; Bugdayci, Derya; Goksenoglu, Goksen; Sen, Aysu; Kesiktas, Nur

2013-01-01

Decreased mobility and walking capacity occur frequently in Parkinson's disease (PD). Robotic treadmill training is a novel method to improve the walking capacity in rehabilitation. The primary aim of this study was to investigate the effects of robotic treadmill training on functional mobility and walking capacity in PD. Secondly, we aimed to assess the effects of the robotic treadmill training the motor symptoms and quality of life in patients with PD. Seventy patients with idiopathic Parkinson's disease who admitted to the outpatient clinic of the rehabilitation hospital were screened and 12 ambulatory volenteers who met the study criteria were included in this study. Patients were evaluated by Hoehn Yahr (HY) scale clinically. Two sessions robotic treadmill training per week during 5 weeks was planned for every patient. Patients were evaluated by the Timed Up and Go (TUG) test, 10 meter walking test (10 MWT), Unified Parkinson's Disease Rating Scale (UPDRS) motor section and Parkinson's Disease Questionnaire-39 (PDQ-39) at the baseline, at the 5 and 12 weeks. Cognitive and emotional states of the patients were assessed by Mini Mental State Examination (MMSE) test and Hospital Anxiety and Depression Scale (HADS) at the baseline. All patients were under medical treatment for the PD in this study and drug treatment was not changed during the study. Ten patients completed the study. The mean age was 65.6 ± 6.6 years. Five patients (50%) were women. Disease severity was between the HY stage 1-3. Two patients did not continue the robotic treadmill training after 7 sessions. They also did not want to come for control visits. TUG test, 10 MWT and UPDRS motor subscale scores showed statistically significant improvement after robotic treadmill training (p = 0.02, p = 0.001, p = 0.016). PDQ-39 scores improved significantly after robotic treadmill training (p = 0.03), however, the scores turned back to the baseline level at the 12. week control. As a result of this

[Cognitive and affective theory of mind in Lewy body dementia: A preliminary study].

Science.gov (United States)

Heitz, C; Vogt, N; Cretin, B; Philippi, N; Jung, B; Phillipps, C; Blanc, F

2015-04-01

'Theory of Mind' refers to the ability to attribute mental states, thoughts (cognitive component) or feelings (affective component), to others. This function has been studied in many neurodegenerative diseases; however, to our knowledge no studies investigating theory of mind in dementia with Lewy Bodies (DLB) have been published. The aim of our study was to search theory of mind deficits in patients with DLB. Seven patients with DLB (DLB group), at the stage of mild dementia or mild cognitive impairments, and seven healthy elderly adults (control group) were included in the study. After a global cognitive assessment, we used the Faux Pas Recognition test to assess the cognitive component of theory of mind, and the Reading the Mind in the Eyes test for the assessment of affective component. We found a significant difference between the two groups for the Faux Pas test with an average score of 35.6 for the DLB group and 48.3 for the control group (P=0.04). Scores were particularly low in the DLB group for the last question of the test concerning empathy (42.9% versus 85%, P=0.01). There was not a significant difference between the two groups for the Reading the Mind in the Eyes test (P=0.077). This preliminary study showed early impairments of theory of mind in the DLB. The cognitive component seems more affected than the affective component in this pathology. This pattern is consistent with the pattern found in Parkinson's disease, but differs from other neurodegenerative diseases as Alzheimer's disease or frontotemporal lobe dementia. These patterns may help to differentiate DLB from these diseases. Further study is needed to confirm these results and to compare with other dementias. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Preliminary performance assessment for the Waste Isolation Pilot Plant, December 1992. Volume 1, Third comparison with 40 CFR 191, Subpart B

Energy Technology Data Exchange (ETDEWEB)

1992-12-01

Before disposing of transuranic radioactive wastes in the Waste Isolation Pilot Plant (WIPP), the United States Department of Energy (DOE) must evaluate compliance with applicable long-term regulations of the United States Environmental Protection Agency (EPA). Sandia National Laboratories is conducting iterative performance assessments of the WIPP for the DOE to provide interim guidance while preparing for final compliance evaluations. This volume contains an overview of WIPP performance assessment and a preliminary comparison with the long-term requirements of the Environmental Radiation Protection Standards for Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes (40 CFR 191, Subpart B).

Imaging popliteal artery disease in young adults with claudication: self-assessment module.

Science.gov (United States)

Chew, Felix S; Bui-Mansfield, Liem T

2007-09-01

The educational objectives of this self-assessment module on imaging popliteal artery disease in young adults with intermittent claudication are for the participant to exercise, self-assess, and improve his or her knowledge of the imaging and clinical features of popliteal artery entrapment syndrome, cystic adventitial disease,and masses associated with popliteal artery obstruction.

Management and Data Management Plan for Remedial Investigation at Fort George G. Meade Landfill and Preliminary Assessment/Site Investigation at the Former Gaithersburg NIKE Control and Launch Areas

National Research Council Canada - National Science Library

Edwards, D

1989-01-01

Work assignments under this contract will include a Preliminary Assessment/Site Investigation at the former Gaithersburg NIKE Control and Launch Areas and a Remedial Investigation at the Fort Meade...

Can the CERAD neuropsychological battery be used to assess cognitive impairment in Parkinson's disease?

Directory of Open Access Journals (Sweden)

Carlos Henrique Ferreira Camargo

Full Text Available ABSTRACT The Consortium to Establish a Registry for Alzheimer's Disease (CERAD neuropsychological battery was created to assess cognitive impairment in Alzheimer's disease (AD but it is widely-used for various dementias. The aim of this study was to analyze the efficacy of using the CERAD battery in the assessment of patients with Parkinson's disease. Forty-nine patients with Parkinson's disease were divided into two groups (one with dementia and one without using the Movement Disorder Society criteria for Parkinson's disease dementia. Cognitive deficits were assessed with the Clinical Dementia Rating Scale as the gold standard, and the CERAD. The ROC curve for the CERAD battery had an area under the curve = 0.989 (95% CI = 0.967 – 1, p<0.0001. Among the CERAD subtests, verbal fluency had the worst accuracy, and word list learning had the best accuracy. Despite the limits of this study, the CERAD battery can be efficient for assessment of cognitive deficits in Parkinson's disease patients.

Preliminary performance assessment for the Waste Isolation Pilot Plant, December 1992

International Nuclear Information System (INIS)

1993-08-01

Before disposing of transuranic radioactive waste in the Waste Isolation Pilot Plant (WIPP), the United States Department of Energy (DOE) must evaluate compliance with applicable long-term regulations of the United States Environmental Protection Agency (EPA). Sandia National Laboratories is conducting iterative performance assessments (PAs) of the WIPP for the DOE to provide interim guidance while preparing for a final compliance evaluation. This volume of the 1992 PA contains results of uncertainty and sensitivity analyses with respect to migration of gas and brine from the undisturbed repository. Additional information about the 1992 PA is provided in other volumes. Volume 1 contains an overview of WIPP PA and results of a preliminary comparison with 40 CFR 191, Subpart B. Volume 2 describes the technical basis for the performance assessment, including descriptions of the linked computational models used in the Monte Carlo analyses. Volume 3 contains the reference data base and values for input parameters used in consequence and probability modeling. Volume 4 contains uncertainty and sensitivity analyses with respect to the EPA's Environmental Standards for the Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes (40 CFR 191, Subpart B). Finally, guidance derived from the entire 1992 PA is presented in Volume 6. Results of the 1992 uncertainty and sensitivity analyses indicate that, conditional on the modeling assumptions and the assigned parameter-value distributions, the most important parameters for which uncertainty has the potential to affect gas and brine migration from the undisturbed repository are: initial liquid saturation in the waste, anhydrite permeability, biodegradation-reaction stoichiometry, gas-generation rates for both corrosion and biodegradation under inundated conditions, and the permeability of the long-term shaft seal

Assessment of disease activity in large-vessel vasculitis

DEFF Research Database (Denmark)

Aydin, Sibel Z.; Direskeneli, Haner; Merkel, Peter A.

2017-01-01

Objective. To arrive at consensus for candidate outcomes for disease activity assessment in largevessel vasculitis (LVV) in clinical trials. Methods.A Delphi survey including 99 items was circulated among international experts for 3 rounds. Results. Fifty-seven items were accepted for both giant ...

Preliminary assessment of pump IST effectiveness

International Nuclear Information System (INIS)

DiBiasio, A.; Grove, E.; Carbonaro, J.

1994-01-01

A preliminary review of Inservice Testing (IST) effectiveness for Code Class 1, 2, and 3 pumps at nuclear power plants was performed. IST requirements are specified by ASME Section XI, and the Operations and Maintenance Standard (OM Part 6). The INPO NPRDS database was used to provide failure reports for these components for 1988 to 1992. This time frame coincides with the issuance of Generic Letter 89-04, which resulted in a more consistent application of the requirements by the licensees. For this time period, 2585 pump failures were reported. A review of these failures indicated that the majority (71.6%) were due to external leakage, and were excluded from this study since these events typically do not affect pump operability and are not detected by the measurement of IST parameters. Of the remaining 733 events, a review was performed to identify the primary failure causes, failure modes, and method of detection. Plant testing programs, consisting of IST, surveillance testing, and special testing, detected approximately 40% of these occurrences. Others were detected through operational abnormalities, routine and incidental observations, alarms, and while performing maintenance. This paper provides a discussion of the results of the study

A Critical Assessment of Research on Neurotransmitters in Alzheimer's Disease.

Science.gov (United States)

Reddy, P Hemachandra

2017-01-01

The purpose of this mini-forum, "Neurotransmitters and Alzheimer's Disease", is to critically assess the current status of neurotransmitters in Alzheimer's disease. Neurotransmitters are essential neurochemicals that maintain synaptic and cognitive functions in mammals, including humans, by sending signals across pre- to post-synaptic neurons. Authorities in the fields of synapses and neurotransmitters of Alzheimer's disease summarize the current status of basic biology of synapses and neurotransmitters, and also update the current status of clinical trials of neurotransmitters in Alzheimer's disease. This article discusses the prevalence, economic impact, and stages of Alzheimer's dementia in humans.

Ethical Values and Biological Diversity: A Preliminary Assessment Approach

Directory of Open Access Journals (Sweden)

Joel I. Cohen

2014-10-01

Full Text Available There have been five major extinction events over geological time. However, the current rate of extinction or reduction of species and their habitats is directly related to anthropomorphic causes. For seventh grade students, biodiversity and its ethical considerations were introduced in a life sciences curriculum, following lessons on evolution, natural selection, and decent from common ancestry. This paper takes a preliminary look at the approach used in this unit, the ethical survey developed, and improvements to be made in subsequent years.

(1'23I)DaTSCAN and SPET imaging of dopamine carrier in Parkinson's disease (preliminary report)

International Nuclear Information System (INIS)

Chmielowski, K.; Szalus, N.; Pakszys, W.; Kulinski, W.; Skrobowska, E.

2003-01-01

The authors present own experience in dopamine carrier imaging by means of SPET and ( 123I ) DaTSCAN in Parkinson's disease. The aim of study was an assessment of the functional status of presynaptic dopaminergic system. The material consisted of three patients including one with spontaneous tremor and two with Parkinson's disease. The study was conducted according to EANM quidelines. The thyroid was blocked with sodium perchlorate administered orally (400 mg). ( 123I )DaTSCAN was injected intravenously. After three hours cerebral SPET was carried out using Varicam gamma camera. Reconstruction of SPET images was performed by the method of filtered retrograde projection using a Butterworth filter. SPET images of the brain were assessed visually and semiquantitatively through fusion and superimposing of SPET and MRI images together with marked templates (ROIs) for the corpus striatum.The obtained cerebral SPET results in three patients confirmed the diagnosis of spontaneous tremor in one case and Parkinson's disease in the remaining two subject. No adverse effects of ( 123I )DaTSCAN administration were found. Cocaine analogue, (sI)DaTSCAN, is an easy, safe and useful diagnostic test in SPET imaging of dopamine carrier in Parkinson's diseases and in spontaneous tremor. (author)

Brain morphometric analysis predicts decline of intelligence quotient in children with sickle cell disease: A preliminary study.

Science.gov (United States)

Chen, Rong; Krejza, Jaroslaw; Arkuszewski, Michal; Zimmerman, Robert A; Herskovits, Edward H; Melhem, Elias R

2017-03-01

For children with sickle cell disease (SCD) and at low risk category of stroke, we aim to build a predictive model to differentiate those with decline of intelligence-quotient (IQ) from counterparts without decline, based on structural magnetic-resonance (MR) imaging volumetric analysis. This preliminary prospective cohort study included 25 children with SCD, homozygous for hemoglobin S, with no history of stroke and transcranial Doppler mean velocities below 170cm/s at baseline. We administered the Kaufman Brief Intelligence Test (K-BIT) to each child at yearly intervals for 2-4 years. Each child underwent MR examination within 30 days of the baseline K-BIT evaluation date. We calculated K-BIT change rates, and used rate of change in K-BIT to classify children into two groups: a decline group and a non-decline group. We then generated predictive models to predict K-BIT decline/non-decline based on regional gray-matter (GM) volumes computed from structural MR images. We identified six structures (the left median cingulate gyrus, the right middle occipital gyrus, the left inferior occipital gyrus, the right fusiform gyrus, the right middle temporal gyrus, the right inferior temporal gyrus) that, when assessed for volume at baseline, are jointly predictive of whether a child would suffer subsequent K-BIT decline. Based on these six regional GM volumes and the baseline K-BIT, we built a prognostic model using the K * algorithm. The accuracy, sensitivity and specificity were 0.84, 0.78 and 0.86, respectively. GM volumetric analysis predicts subsequent IQ decline for children with SCD. Copyright © 2017 Medical University of Bialystok. Published by Elsevier B.V. All rights reserved.

Assessement of rheumatic diseases with computational radiology: current status and future potential

DEFF Research Database (Denmark)

Peloschek, Philipp; Boesen, Mikael; Donner, Rene

2009-01-01

In recent years, several computational image analysis methods to assess disease progression in rheumatic diseases were presented. This review article explains the basics of these methods as well as their potential application in rheumatic disease monitoring, it covers radiography, sonography...

Patient satisfaction with a chronic kidney disease risk assessment service in community pharmacies.

Science.gov (United States)

Gheewala, Pankti A; Peterson, Gregory M; Zaidi, Syed Tabish R; Jose, Matthew D; Castelino, Ronald L

2018-04-01

Patient satisfaction is an important determinant of the feasibility and sustainability of community pharmacy screening services. However, few studies have evaluated this, with no such study performed for a chronic kidney disease risk assessment service. The aim was to determine patient satisfaction with a chronic kidney disease risk assessment service performed in community pharmacies. Community pharmacies in the state of Tasmania, Australia. An anonymous nine-item satisfaction survey, with Likert-type scales, was developed following a literature review of existing surveys. Reliability of the nine-item scale was determined using Cronbach's alpha. Patients were asked an additional question on willingness to pay, with choices of amount from $5 to $25. The satisfaction survey was mailed to 389 patients who participated in the chronic kidney disease risk assessment study. Patient level of satisfaction with and willingness to pay for the chronic kidney disease service. Responses from 143 participants were included in the final analysis. Cronbach's alpha for the nine-item satisfaction scale was 0.87. The majority of participants agreed that the time required to undergo the risk assessment process was justified (90.2%); overall, they were satisfied with the chronic kidney disease risk assessment service (90.0%) and they felt comfortable with the pharmacist referring their results to their doctor (88.9%). Of 136 participants who answered the question on willingness to pay, 62.9% indicated that they would pay for the chronic kidney disease service. Of these, 29.2, 25.8 and 19.1% were willing to pay $20, $10 and $5, respectively. Patient satisfaction with the community pharmacy-based chronic kidney disease risk assessment was high. These findings provide support for the implementation of the service within community pharmacy practice.

Assessment of the knowledge and attitudes of preliminary school students toward smoking in Baghdad

Directory of Open Access Journals (Sweden)

Abbas Jabbar Sahib

2016-03-01

Full Text Available Background: Early smoking considered as a major challenge for health promoters, as well it is socially not acceptable, thus interventions must tackle childhood starts of smoking.Aim: Assessing the knowledge and attitude of preliminary students towards tobacco use. Methods: A cross-sectional study conducted among 2195, 5th grade students from 30 preliminary schools in Baghdad (15 from each side Karkh & Rusafa during November 2014. They were selected by multistage sampling technique.Results:  Participated students age ranged between (10-13 years and (51.9% of them were girls, (54.3% of their parents were nonsmoker while the rest reported that both or one of them are smokers, direct and indirect risks of cigarette  smoking were known by (82.4% and (66.2% respectively, and (70.8% of students’ families were found to wear their kids from smoking hazards, while more than (50% of them have received health education massages from their teachers. Sitting near smoker person was not in favor of (86.2% of the participants, as (51.4% considered it religiously inconvenient and (34.6% considered smoking as a sign of no self-confidence. At last, (73.7% of the surveyed students agreed with smoking prohibition in public places while (25.8% opposed that.Conclusion: In spite of the high percentage of students’ parents were smokers; nevertheless, risks of smoking are well known by the surveyed students and they showed positive attitudes toward smoking prohibition in public places. Parental advising for quit smoking and urging teachers to educate their students about smoking hazards are thought to be the right action.

Utility analysis and calibration of QOL assessment in disease management.

Science.gov (United States)

Liu, Mo

2018-05-02

In clinical trials, the assessment of health-related quality of life (QOL) (or patient-reported outcome [PRO] measure) has become very popular especially for clinical studies conducted for evaluating clinical benefits of patients with chronic, severe, and/or life threatening diseases. Health-related QOL information and PRO measures are useful for disease management for achieving best clinical practice. In this article, we will focus on health-related QOL assessment. The concept, design, and analysis of health-related QOL in clinical trials are reviewed. Validation of the use of health-related QOL instrument in terms of some key performance characteristics such as accuracy, reliability, sensitivity, and responsibility for assuring quality, integrity, and validity of collected QOL data are discussed. The concept of utility analysis and calibration (e.g., with respect to life events) for achieving the optimization of disease management are proposed. The change of the QOL could be translated into different life events for effective disease management. These translations could evaluate the treatment effect by more directly displaying the change of the QOL.

Application of the preliminary Geosite Assessment Model (GAM: The case of the Bela Crkva municipality (Vojvodina, north Serbia

Directory of Open Access Journals (Sweden)

Boškov Jovana

2015-01-01

Full Text Available Bela Crkva municipality is located in the northeastern part of Serbia, in the Southeast of the Autonomous Province of Vojvodina. This Municipality has a high concentration of geo sites which are of a great importance, and providing a good basis for the geo tourism development in this area. This paper proposes an inventory of geo sites in the Bela Crkva municipality. One of the aims of the paper is to evaluate different values of geo sites using preliminary Geosite Assessment Model (GAM in order to determine whether this area has the potential for geo tourism development.

Occupational exposure assessment in a radioactive facility: a preliminary evaluation

International Nuclear Information System (INIS)

Alves, Alice dos Santos; Gerulis, Eduardo; Sanches, Matias P.; Carneiro, Janete C.G.G.

2013-01-01

The risk that a worker has found on the job is a function of the hazards present and his exposure level to those hazards. Exposure and risk assessment is therefore the heart of all occupational health and industrial hygiene programs involving a continuous process of information gathering. The use of a systematic method to characterize workplace exposures to chemical, physical and biological risks is a fundamental part of this process. This study aims to carry out a preliminary evaluation in a radioactive facility, identifying potential exposures and consequently the existing occupational hazards (risk/agent) in the workplace which the employee is subject. The study is based on proposal to carry out a basic characterization of the facility, which could be the first step in the investigation of occupational exposure. For this study was essential to know the workplace, potential risks and agents; workforce profile including assignment of tasks, sources of exposure processes, and control measures. The main tool used in this study was based on references, records, standards, procedures, interviews with the workers and with management. Since the basic characterization of the facility has been carried out, consequently the potential exposure to the agents of risks to workers has been identified. The study provided an overview of the perception of risk founded at facility studied. It is expected to contribute with the occupational health program resources for welfare of the worker. (author)

Occupational exposure assessment in a radioactive facility: a preliminary evaluation

Energy Technology Data Exchange (ETDEWEB)

Alves, Alice dos Santos; Gerulis, Eduardo; Sanches, Matias P.; Carneiro, Janete C.G.G., E-mail: alicesante@hotmail.com [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

2013-07-01

The risk that a worker has found on the job is a function of the hazards present and his exposure level to those hazards. Exposure and risk assessment is therefore the heart of all occupational health and industrial hygiene programs involving a continuous process of information gathering. The use of a systematic method to characterize workplace exposures to chemical, physical and biological risks is a fundamental part of this process. This study aims to carry out a preliminary evaluation in a radioactive facility, identifying potential exposures and consequently the existing occupational hazards (risk/agent) in the workplace which the employee is subject. The study is based on proposal to carry out a basic characterization of the facility, which could be the first step in the investigation of occupational exposure. For this study was essential to know the workplace, potential risks and agents; workforce profile including assignment of tasks, sources of exposure processes, and control measures. The main tool used in this study was based on references, records, standards, procedures, interviews with the workers and with management. Since the basic characterization of the facility has been carried out, consequently the potential exposure to the agents of risks to workers has been identified. The study provided an overview of the perception of risk founded at facility studied. It is expected to contribute with the occupational health program resources for welfare of the worker. (author)

A Preliminary Assessment of Buddhism's Contextualisation to the English RE Classroom

Science.gov (United States)

Thanissaro, Phra Nicholas

2011-01-01

In a preliminary study, 20 "migrant" Buddhist parents and children from England participated in semi-structured interviews to compare their home nurture with classroom presentation of Buddhism. In the home Buddhism received more time allocation and was presented mainly by the mother and monks--the content being that of "perpetuating…

Feasibility, safety, acceptability, and preliminary efficacy of measurement-based care depression treatment for HIV patients in Bamenda, Cameroon.

Science.gov (United States)

Pence, Brian W; Gaynes, Bradley N; Atashili, Julius; O'Donnell, Julie K; Kats, Dmitry; Whetten, Kathryn; Njamnshi, Alfred K; Mbu, Tabenyang; Kefie, Charles; Asanji, Shantal; Ndumbe, Peter

2014-06-01

Depression affects 18-30 % of HIV-infected patients in Africa and is associated with greater stigma, lower antiretroviral adherence, and faster disease progression. However, the region's health system capacity to effectively identify and treat depression is limited. Task-shifting models may help address this large mental health treatment gap. Measurement-Based Care (MBC) is a task-shifting model in which a Depression Care Manager guides a non-psychiatric (e.g., HIV) provider in prescribing and managing antidepressant treatment. We adapted MBC for depressed HIV-infected patients in Cameroon and completed a pilot study to assess feasibility, safety, acceptability, and preliminary efficacy. We enrolled 55 participants; all started amitriptyline 25-50 mg daily at baseline. By 12 weeks, most remained at 50 mg daily (range 25-125 mg). Median (interquartile range) PHQ-9 depressive severity scores declined from 13 (12-16) (baseline) to 2 (0-3) (week 12); 87 % achieved depression remission (PHQ-9 feasibility, safety, acceptability, and preliminary efficacy in this uncontrolled pilot study. Further research should assess whether MBC could improve adherence and HIV outcomes in this setting.

Episodic memory impairment in Addison's disease: results from a telephonic cognitive assessment.

Science.gov (United States)

Henry, Michelle; Thomas, Kevin G F; Ross, Ian L

2014-06-01

Patients with Addison's disease frequently self-report memory and attention difficulties, even when on standard replacement therapy. However, few published studies examine, using objective measures and assessing across multiple domains, the cognitive functioning of Addison's disease patients relative to healthy controls. The primary aim of this study was to investigate whether the previously reported subjective cognitive deficits in Addison's disease are confirmed by objective measures. Conducting comprehensive neuropsychological assessments of patients with relatively rare clinical disorders, such as Addison's disease, is challenging because access to those patients is often limited, and because their medical condition might prevent extended testing sessions. Brief telephonic cognitive assessments are a useful tool in such circumstances. Hence, we administered the Brief Test of Adult Cognition by Telephone to 27 Addison's disease patients and 27 matched healthy controls. The instrument provides objective assessment of episodic memory, working memory, executive functioning, reasoning, and speed of processing. Statistical analyses confirmed that, as expected, patients performed significantly more poorly than controls on the episodic memory subtest. There were, however, no significant between-group differences on the attention, executive functioning, reasoning, and speed of processing subtests. Furthermore, patients with a longer duration of illness performed more poorly across all domains of cognition. We conclude that, for Addison's disease patients, previously reported subjective cognitive deficits are matched by objective impairment, but only in the domain of episodic memory. Future research might investigate (a) whether these memory deficits are material-specific (i.e., whether non-verbal memory is also affected), and (b) the neurobiological mechanisms underlying these deficits.

Lyme Disease in West Virginia: An Assessment of Distribution and Clinicians' Knowledge of Disease and Surveillance.

Science.gov (United States)

Singh, Sarah; Parker, David; Mark-Carew, Miguella; White, Robert; Fisher, Melanie

2016-01-01

Lyme disease case misclassification, a top public health concern, may be attributed to the current disconnect between clinical diagnosis and surveillance. This study examines Lyme disease distribution in West Virginia (WV) and determines clinicians' knowledge of both disease and surveillance. Lyme disease surveillance data for 2013 were obtained from the WV Bureau for Public Health. A validated survey, distributed to clinicians at an academic medical center, assessed clinicians' knowledge of disease diagnosis and surveillance. There were 297 adult Lyme disease cases of which 83 were confirmed. Clinician survey responses resulted in a correct response rate of 70% for Lyme disease knowledge questions. Fewer than half of all clinicians were aware of the surveillance criteria for confirming Lyme disease cases. Neither medical specialty nor previous treatment of patients with Lyme disease were significantly associated with clinicians' knowledge of the disease. Clinicians in WV are familiar with symptoms and clinical management of Lyme disease. However, they are less knowledgeable about diagnosis and public health surveillance comprising reporting and confirming cases of the disease. Clinicians and public health authorities should collaborate more closely to promote education and awareness as a key step to successfully reducing the burden of Lymne disease.

Quality of life in patients with coronary heart disease-I: Assessment tools

Directory of Open Access Journals (Sweden)

Yu Cheuk-Man

2003-09-01

Full Text Available Abstract Health-related quality of life (HRQL assessment is an important measure of the impact of the disease, effect of treatment and other variables affecting people's lives. The review focused on the assessment of HRQL in patient with coronary heart disease (CHD by appropriate tools. Although no consensus exists about the precise definition of HRQL, a plethora of instruments have been developed to assess it. Two broad types – generic and disease-specific – have been developed but there is some debate about their relative merits. There is a wide selection of instruments available but choice should be based on a careful consideration of an instrument's psychometric properties, the breadth and depth with which it addresses relevant health domains and the specific clinical or research purpose for which it is intended.

Assessing arthropod pests and disease occurrence in cassava ...

African Journals Online (AJOL)

On-station trials were conducted at CSIR-Crops Research Institute's research farms at Kwadaso and Ejura, Ashanti Region, Ghana, during 2010/2011 cropping season, to assess the pests and disease occurrence in cassava-cowpea intercrop farming systems and their effect on yield of produce. Three improved cassava ...

Assessing nutritional status in children with chronic liver disease.

Science.gov (United States)

Taylor, Rachel M; Dhawan, Anil

2005-12-01

The metabolic changes compounded by anorexia associated with chronic liver disease adversely affect growth in children. In many cases, this requires the administration of artificial nutritional support. It is important in this group of patients that those who are becoming nutritionally depleted are identified quickly and in those receiving artificial nutritional support, the effectiveness is monitored. The current review is an examination of methods available to assess nutritional status. These include anthropometry, methods available in the laboratory and a selection of less commonly used methods undergoing evaluation at research level. A brief discussion accompanies each technique, outlining the limitations of its use in children with chronic liver disease. The review concludes with an outline of how nutritional status should be assessed in this group of children, and suggests further research.

Preliminary results on response assessment using {sup 68}Ga-HBED-CC-PSMA PET/CT in patients with metastatic prostate cancer undergoing docetaxel chemotherapy

Energy Technology Data Exchange (ETDEWEB)

Seitz, Anna Katharina [Technical University of Munich, Department of Urology, Klinikum rechts der Isar, Munich (Germany); Julius Maximilians University Medical Centre of Wuerzburg, Department of Urology and Paediatric Urology, Wuerzburg (Germany); Rauscher, Isabel; Kroenke, Markus; Schwaiger, Markus [Technical University of Munich, Department of Nuclear Medicine, Klinikum rechts der Isar, Munich (Germany); Haller, Bernhard [Technical University of Munich, Institute of Medical Informatics, Statistics and Epidemiology, Klinikum rechts der Isar, Munich (Germany); Luther, Sophia; Heck, Matthias M.; Horn, Thomas; Gschwend, Juergen E.; Maurer, Tobias [Technical University of Munich, Department of Urology, Klinikum rechts der Isar, Munich (Germany); Eiber, Matthias [Technical University of Munich, Department of Nuclear Medicine, Klinikum rechts der Isar, Munich (Germany); David Geffen School of Medicine at UCLA, Department of Molecular and Medical Pharmacology, Los Angeles (United States)

2018-04-15

lesions on CT. {sup 68}Ga-PSMA PET and CT results corresponded in seven of 12 patients (58%, 28% to 85%). Our preliminary results suggest that {sup 68}Ga-PSMA PET might be a promising method for treatment response assessment in mCSPC and mCRPC. The data indicate that for different metastatic sites, the performance of {sup 68}Ga-PSMA PET in response assessment might be superior to that of the conventional CT approach and could help differentiate between progressive disease and treatment response. Because of the limited number of patients, the differences revealed in our study were not statistically significant. Thus larger and prospective studies are clearly needed and warranted to confirm the value of {sup 68}Ga-PSMA PET as an imaging biomarker for response assessment. (orig.)

Scale-Dependent Assessment of Relative Disease Resistance to Plant Pathogens

Directory of Open Access Journals (Sweden)

Peter Skelsey

2014-03-01

Full Text Available Phenotyping trials may not take into account sufficient spatial context to infer quantitative disease resistance of recommended varieties in commercial production settings. Recent ecological theory—the dispersal scaling hypothesis—provides evidence that host heterogeneity and scale of host heterogeneity interact in a predictable and straightforward manner to produce a unimodal (“humpbacked” distribution of epidemic outcomes. This suggests that the intrinsic artificiality (scale and design of experimental set-ups may lead to spurious conclusions regarding the resistance of selected elite cultivars, due to the failure of experimental efforts to accurately represent disease pressure in real agricultural situations. In this model-based study we investigate the interaction of host heterogeneity and scale as a confounding factor in the inference from ex-situ assessment of quantitative disease resistance to commercial production settings. We use standard modelling approaches in plant disease epidemiology and a number of different agronomic scenarios. Model results revealed that the interaction of heterogeneity and scale is a determinant of relative varietal performance under epidemic conditions. This is a previously unreported phenomenon that could provide a new basis for informing the design of future phenotyping platforms, and optimising the scale at which quantitative disease resistance is assessed.

Preliminary assessment of pump IST effectiveness

International Nuclear Information System (INIS)

DiBiasio, A.; Grove, E.; Carbonaro, J.

1994-01-01

A preliminary review of inservice testing (IST) effectiveness for Class 1, 2, and 3 pumps at nuclear power plants was performed. IST requirements are specified by the American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel Code, Section XI, and the Operations and Maintenance Standard (OM Part 6). The Institute of Nuclear Power Operations Nuclear Plant Reliability Data System was used to provide failure reports for these components from 1988 to 1992. This time frame coincides with the issuance of Generic Letter 89-04, which resulted in a more consistent application of the requirements by the licensees. For this time, 2,585 pump failures were reported. A review of these failures indicated that the majority (71.6%) resulted from external leakage. These events were excluded from the study because the typically do not affect pump operability and are not detected by the measurement of IST parameters. The remaining 733 events were reviewed to identify the primary failure causes, failure modes, and method of detection. Plant testing programs, consisting of IST, surveillance testing, detected approximately 40% of these occurrences. Others were detected through operational abnormalities, routine and incidental observations, alarms, and while performing maintenance. This paper discusses the results of the study

Site 300 hazardous-waste-assessment project. Interim report: December 1981. Preliminary site reconnaissance and project work plan

International Nuclear Information System (INIS)

Raber, E.; Helm, D.; Carpenter, D.; Peifer, D.; Sweeney, J.

1982-01-01

This document was prepared to outline the scope and objectives of the Hazardous Waste Assessment Project (HWAP) at Site 300. This project was initiated in October, 1981, to investigate the existing solid waste landfills in an effort to satisfy regulatory guidelines and assess the potential for ground-water contamination. This involves a site-specific investigation (utilizing geology, hydrology, geophysics and geochemistry) with the goal of developing an effective ground-water quality monitoring network. Initial site reconnaissance work has begun and we report the results, to date, of our geologic hydrogeologic studies. All known solid waste disposal locations are underlain by rocks of either the Late Miocene Neroly Formation or the Cierbo Formation, both of which are dominantly sandstones interbedded with shale and claystone. The existence of a regional confined (artesian) aquifer, as well as a regional water-table aquifer is postulated for Site 300. Preliminary analysis has led to an understanding of directions and depths of regional ground-water flow

Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): Borna disease

DEFF Research Database (Denmark)

EFSA Panel on Animal Health and Welfare; More, Simon J.; Bøtner, Anette

2017-01-01

Borna disease has been assessed according to the criteria of the Animal Health Law (AHL), in particular criteria of Article 7 on disease profile and impacts, Article 5 on the eligibility of Borna disease to be listed, Article 9 for the categorisation of Borna disease according to disease prevention...... at collective level. The output is composed of the categorical answer, and for the questions where no consensus was reached, the different supporting views are reported. Details on the methodology used for this assessment are explained in a separate opinion. According to the assessment performed, Borna disease...

Automatic and objective assessment of alternating tapping performance in Parkinson's disease.

Science.gov (United States)

Memedi, Mevludin; Khan, Taha; Grenholm, Peter; Nyholm, Dag; Westin, Jerker

2013-12-09

This paper presents the development and evaluation of a method for enabling quantitative and automatic scoring of alternating tapping performance of patients with Parkinson's disease (PD). Ten healthy elderly subjects and 95 patients in different clinical stages of PD have utilized a touch-pad handheld computer to perform alternate tapping tests in their home environments. First, a neurologist used a web-based system to visually assess impairments in four tapping dimensions ('speed', 'accuracy', 'fatigue' and 'arrhythmia') and a global tapping severity (GTS). Second, tapping signals were processed with time series analysis and statistical methods to derive 24 quantitative parameters. Third, principal component analysis was used to reduce the dimensions of these parameters and to obtain scores for the four dimensions. Finally, a logistic regression classifier was trained using a 10-fold stratified cross-validation to map the reduced parameters to the corresponding visually assessed GTS scores. Results showed that the computed scores correlated well to visually assessed scores and were significantly different across Unified Parkinson's Disease Rating Scale scores of upper limb motor performance. In addition, they had good internal consistency, had good ability to discriminate between healthy elderly and patients in different disease stages, had good sensitivity to treatment interventions and could reflect the natural disease progression over time. In conclusion, the automatic method can be useful to objectively assess the tapping performance of PD patients and can be included in telemedicine tools for remote monitoring of tapping.

Preliminary assessment on the competency of technical staff of Atomic Energy Licensing Board

International Nuclear Information System (INIS)

Marina Mishar; Redzuwan Yahya

2010-01-01

The main purpose of this study is to carry out a preliminary assessment on the competency level of technical staff of Atomic Energy Licensing Board (AELB), the nuclear regulatory body in Malaysia for effectively monitoring and supervising the activities of the first nuclear power plant in Malaysia. The study is conducted out on the whole group of AELB technical staff, comprising 81 personnel from the supporting and professional categories. Findings showed that AELB technical staff who have been in the workforce for more than ten years have the required competency level for legal and regulatory processes competencies, regulatory practices competencies and effectiveness in personal and inter-personal competencies. Regression analysis between competency and working experience (length of service) showed a weak positive correlation, which could be contributed by job not related to the competency parameters for major functions of a regulatory body in controlling nuclear activity of a nuclear power plant. Results obtained could assist AELB in manpower development once Malaysia makes the decision to embark on a nuclear power programme. (author)

French 900 MWe PWR PSA preliminary results

International Nuclear Information System (INIS)

Lanore, J.M.; Brisbois, J.

1988-10-01

A PSA is performed by the Safety Assessment Department of CEA for a 900 MWe standardized plant. The paper presents the objectives, the scope of the study and the relative preliminary results. Some general insights are drawn, especially the benefit related to the implementation of emergency procedures

Assessment of mixed hazardous and radioactive waste sites at Hanford

International Nuclear Information System (INIS)

McLaughlin, T.J.; Cramer, K.H.; Lamar, D.A.; Sherwood, D.R.; Stenner, R.D.; Schulze, W.B.

1987-10-01

The US Department of Energy and Pacific Northwest Laboratory recently completed a preliminary assessment of 685 inactive hazardous waste sites located on the Hanford Site. The preliminary assessment involved collecting historical data and individual site information, conducting site inspections, and establishing an environmental impact priority, using the Hazard Ranking System, for each of these 685 sites. This preliminary assessment was the first step in the remediation process required by the Comprehensive Environmental Response, Compensation and Liability Act. This paper presents the results of that preliminary assessment. 10 refs., 4 figs., 1 tab

A preliminary investigation for application of an advanced x-ray diffraction analyzer to in-process texture assessment of aluminum alloy sheet

International Nuclear Information System (INIS)

Ruud, C.O.; Snoha, D.J.

1989-01-01

The objective of this preliminary investigation was to assess the possibility of the use of rapid x-ray diffraction technology to nondestructively distinguish various texture conditions of aluminum can stock. Twelve samples of aluminum alloy can stock sheet were supplied by two manufacturers. The samples varied in thickness from 0.128 to 0.0124 inch and in texture from 2.8% to 11.0% as measured by a cup drawing earing test. The results for Cu K-alpha and Cr K-alpha radiation on suites of aluminum can stock samples from two manufacturers, in both hot rolled can stock precursor gages of 0.80 and 0.125 inch and in the final gage, show there is a good correlation between the peak intensity area function and the texture. These preliminary results provide an indication that the instrumentation and techniques applied could be optimized and refined for application to rapid, in-process nondestructive inspection of rolled aluminum can stock

Assessement of rheumatic diseases with computational radiology: Current status and future potential

International Nuclear Information System (INIS)

Peloschek, Philipp; Boesen, Mikael; Donner, Rene; Kubassova, Olga; Birngruber, Erich; Patsch, Janina; Mayerhoefer, Marius; Langs, Georg

2009-01-01

In recent years, several computational image analysis methods to assess disease progression in rheumatic diseases were presented. This review article explains the basics of these methods as well as their potential application in rheumatic disease monitoring, it covers radiography, sonography as well as magnetic resonance imaging in quantitative analysis frameworks.

Grid-connected ICES: preliminary feasibility analysis and evaluation. Volume 2. Final report

Energy Technology Data Exchange (ETDEWEB)

1977-06-30

The HEAL Complex in New Orleans will serve as a Demonstration Community for which the ICES Demonstration System will be designed. The complex is a group of hospitals, clinics, research facilities, and medical educational facilities. The five tasks reported on are: preliminary energy analysis; preliminary institutional assessment; conceptual design; firming-up of commitments; and detailed work management plan.

Early chronic obstructive pulmonary disease: definition, assessment, and prevention.

Science.gov (United States)

Rennard, Stephen I; Drummond, M Bradley

2015-05-02

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. COPD, however, is a heterogeneous collection of diseases with differing causes, pathogenic mechanisms, and physiological effects. Therefore a comprehensive approach to COPD prevention will need to address the complexity of COPD. Advances in the understanding of the natural history of COPD and the development of strategies to assess COPD in its early stages make prevention a reasonable, if ambitious, goal. Copyright © 2015 Elsevier Ltd. All rights reserved.

[Nutritional Assessment and Management for Patients with Chronic Liver Disease].

Science.gov (United States)

Lee, Tae Hee

2018-04-25

When liver disease is severe, the prognosis can be worse if the patient is malnourished. Adequate nutritional support for patients with liver diseases can improve the patient's condition and prognosis. In the case of liver cirrhosis, malnutrition can occur due to a variety of causes, including poor oral intake, maldigestion, malabsorption, associated renal disease, and metabolic abnormalities. For a nutritional assessment, it is important to check the dietary intake, change in body composition, including anthropometry, and a functional assessment of muscle. Counselling and oral or enteral nutrition is preferred over parenteral nutrition as in other diseases. If esophageal varices are present, care should be taken when installing a feeding tube, but if there are ascites, percutaneous endoscopic gastrostomy is contraindicated because of the risk of complications. Calories of 30-35 kcal/kg/day and protein from 1.2 to 1.5 g/kg/day are appropriate. Protein restriction is unnecessary unless the hepatic encephalopathy is severe. A late evening snack and branched chain amino acids can be helpful. In the case of cholestasis, the supply of manganese and copper should be restricted. Sarcopenia in patients with liver cirrhosis is also prevalent and associated with the prognosis.

Parthenium dermatitis severity score to assess clinical severity of disease

Directory of Open Access Journals (Sweden)

Kaushal K Verma

2017-01-01

Full Text Available Background: Parthenium dermatitis is the most common type of airborne contact dermatitis in India. It is a chronic disease of a remitting and relapsing course with significant morbidity and distress, but there is no scoring system to assess its severity. Aim: To design a scoring system for the assessment of clinical severity of disease in Parthenium dermatitis and to use this scoring system in various studies to determine its sensitivity, specificity, and reproducibility. Methods and Results: In our first few studies on Parthenium dermatitis, we designed and used a basic clinical severity scoring system based on itching, morphology of the lesions, and areas involved. However, in subsequent studies, we modified it to the present scoring system as Parthenium dermatitis severity score (PDSS. Our studies showed the high sensitivity of PDSS in characterization of the disease severity at the given point of time, as well as to determine the efficacy of a prescribed treatment modality which was reliable and reproducible. Conclusion: Thus, PDSS may be used by clinicians for appropriate scoring of the clinical severity of Parthenium dermatitis and in monitoring the disease response to therapy.

Positive Psychology Interventions for Patients With Heart Disease: A Preliminary Randomized Trial.

Science.gov (United States)

Nikrahan, Gholam Reza; Suarez, Laura; Asgari, Karim; Beach, Scott R; Celano, Christopher M; Kalantari, Mehrdad; Abedi, Mohammad Reza; Etesampour, Ali; Abbas, Rezaei; Huffman, Jeff C

2016-01-01

Positive psychologic characteristics have been linked to superior cardiac outcomes. Accordingly, in this exploratory study, we assessed positive psychology interventions in patients who had recently undergone a procedure to treat cardiovascular disease. Participants were randomly assigned to receive 1 of 3 different 6-week face-to-face interventions or a wait-list control condition. We assessed intervention feasibility and compared changes in psychologic outcome measures postintervention (7wk) and at follow-up (15wk) between intervention and control participants. Across the interventions, 74% of assigned sessions were completed. When comparing outcomes between interventions and control participants (N = 55 total), there were no between-group differences post-intervention, but at follow-up intervention participants had greater improvements in happiness (β = 14.43, 95% CI: 8.66-20.2, p psychology intervention for cardiac patients. Copyright © 2016 The Academy of Psychosomatic Medicine. Published by Elsevier Inc. All rights reserved.

Electromagnetic fields: risk assessment and occupational diseases in Italy

Energy Technology Data Exchange (ETDEWEB)

Filosa, L.; Frusteri, L. [Risk Assessment and Prevention, Technical Advisory Dept., Italian Workers Compensation Authority, Rome (Italy)

2006-07-01

Every year about 8000 occupational diseases are accepted in Italy by I.N.A.I.L., the Italian Workers' Compensation Authority. The occupational diseases are caused by different agents (chemical, biological, physical) but only a very little percentage resulted to be caused by non ionizing radiations. In this paper the Authors report an analysis of occupational diseases caused by non ionising radiations denounced to I.N.A.I.L. and compensated. It is discussed the Italian situation in light of the controversial studies related to the link between exposure and health effects. Because of the uncertainty about an E.M.F. - health link, the main effort is to determine the probability and seriousness of E.M.F. hazard and to realize an accurate risk assessment at workplace, which is one of the main objectives pursued by I.N.A.I.L. Technical Advisory Department for Risk Assessment and Prevention. Moreover, in this paper it is also reported the state of advancement of Italian legislation on health protection against non ionizing radiations at workplace in view of the new European Directive (2004/40/C.E.). (authors)

Electromagnetic fields: risk assessment and occupational diseases in Italy

International Nuclear Information System (INIS)

Filosa, L.; Frusteri, L.

2006-01-01

Every year about 8000 occupational diseases are accepted in Italy by I.N.A.I.L., the Italian Workers' Compensation Authority. The occupational diseases are caused by different agents (chemical, biological, physical) but only a very little percentage resulted to be caused by non ionizing radiations. In this paper the Authors report an analysis of occupational diseases caused by non ionising radiations denounced to I.N.A.I.L. and compensated. It is discussed the Italian situation in light of the controversial studies related to the link between exposure and health effects. Because of the uncertainty about an E.M.F. - health link, the main effort is to determine the probability and seriousness of E.M.F. hazard and to realize an accurate risk assessment at workplace, which is one of the main objectives pursued by I.N.A.I.L. Technical Advisory Department for Risk Assessment and Prevention. Moreover, in this paper it is also reported the state of advancement of Italian legislation on health protection against non ionizing radiations at workplace in view of the new European Directive (2004/40/C.E.). (authors)

Rasa Nirdhāraṇa (assessment of taste of Leonotis nepetifolia (L. R. Br.: A preliminary study in healthy volunteers

Directory of Open Access Journals (Sweden)

Reshmi Pushpan

2014-01-01

Results and Conclusion: On analyzing the data it was found that Leonotis nepetifolia possess predominantly tikta rasa (bitter taste followed by Kasāya rasa (astringent taste. Recent researches and ethnomedicinal claims on Leonotis nepetifolia stand comparable with the pharmacological activities attributed to tikta and kasāya rasa in Ayurvedic classics Rasa nirdhāraṇa can be one of the preliminary steps to initiate the process of screening of an unknown drug along the lines of Ayurvedic pharmacology specially because rasa is the only perceivable parameter. According to Ayurveda, rasa of a dravya has a bearing on its karma (pharmacological action and the identification of rasa could be one of the subjective means for inferring pāρcabhautika constitution of a substance which in turn could help in tentatively inferring guṇa, vîrya and vipāka of the dravya. This paper demonstrates how a simple method can be used without any instruments to do a preliminary assessment of the rasa or taste of a plant.

Development and preliminary evaluation of a music-based attention assessment for patients with traumatic brain injury.

Science.gov (United States)

Jeong, Eunju; Lesiuk, Teresa L

2011-01-01

Impairments in attention are commonly seen in individuals with traumatic brain injury (TBI). While visual attention assessment measurements have been rigorously developed and frequently used in cognitive neurorehabilitation, there is a paucity of auditory attention assessment measurements for patients with TBI. The purpose of this study was to field test a researcher-developed Music-based Attention Assessment (MAA), a melodic contour identification test designed to assess three different types of attention (i.e., sustained attention, selective attention, and divided attention), for patients with TBI. Additionally, this study aimed to evaluate the readability and comprehensibility of the test items and to examine the preliminary psychometric properties of the scale and test items. Fifteen patients diagnosed with TBI completed 3 different series of tasks in which they were required to identify melodic contours. The resulting data showed that (a) test items in each of the 3 subtests were found to have an easy to moderate level of item difficulty and an acceptable to high level of item discrimination, and (b) the musical characteristics (i.e., contour, congruence, and pitch interference) were found to be associated with the level of item difficulty, and (c) the internal consistency of the MAA as computed by Cronbach's alpha was .95. Subsequent studies using a larger sample of typical participants, along with individuals with TBI, are needed to confirm construct validity and internal consistency of the MAA. In addition, the authors recommend examination of criterion validity of the MAA as correlated with current neuropsychological attention assessment measurements.

Assessment of disease activity in juvenile idiopathic arthritis. The number and the size of joints matter

DEFF Research Database (Denmark)

Berntson, Lillemor; Wernroth, Lisa; Fasth, Anders

2007-01-01

Variables for assessment of disease activity of juvenile idiopathic arthritis (JIA) were studied, in order to develop a disease activity score for children with JIA.......Variables for assessment of disease activity of juvenile idiopathic arthritis (JIA) were studied, in order to develop a disease activity score for children with JIA....

Deep repository for long-lived low- and intermediate-level waste. Preliminary safety assessment

International Nuclear Information System (INIS)

1999-11-01

A preliminary safety assessment has been performed of a deep repository for long-lived low- and intermediate-level waste, SFL 3-5. The purpose of the study is to investigate the capacity of the facility to act as a barrier to the release of radionuclides and toxic pollutants, and to shed light on the importance of the location of the repository site. A safety assessment (SR 97) of a deep repository for spent fuel has been carried out at the same time. In SR 97, three hypothetical repository sites have been selected for study. These sites exhibit fairly different conditions in terms of hydrogeology, hydrochemistry and ecosystems. To make use of information and data from the SR 97 study, we have assumed that SFL 3-5 is co-sited with the deep repository for spent fuel. A conceivable alternative is to site SFL 3-5 as a completely separate repository. The focus of the SFL 3-5 study is a quantitative analysis of the environmental impact for a reference scenario, while other scenarios are discussed and analyzed in more general terms. Migration in the repository's near- and far-field has been taken into account in the reference scenario. Environmental impact on the three sites has also been calculated. The calculations are based on an updated forecast of the waste to be disposed of in SFL 3-5. The forecast includes radionuclide content, toxic metals and other substances that have a bearing on a safety assessment. The safety assessment shows how important the site is for safety. Two factors stand out as being particularly important: the water flow at the depth in the rock where the repository is built, and the ecosystem in the areas on the ground surface where releases may take place in the future. Another conclusion is that radionuclides that are highly mobile and long-lived, such as 36 Cl and 93 Mo , are important to take into consideration. Their being long-lived means that barriers and the ecosystems must be regarded with a very long time horizon

Seasonal occurrence, removal efficiencies and preliminary risk assessment of multiple classes of organic UV filters in wastewater treatment plants.

Science.gov (United States)

Tsui, Mirabelle M P; Leung, H W; Lam, Paul K S; Murphy, Margaret B

2014-04-15

Organic ultraviolet (UV) filters are applied widely in personal care products (PCPs), but the distribution and risks of these compounds in the marine environment are not well known. In this study, the occurrence and removal efficiencies of 12 organic UV filters in five wastewater treatment plants (WWTPs) equipped with different treatment levels in Hong Kong, South China, were investigated during one year and a preliminary environmental risk assessment was carried out. Using a newly developed simultaneous multiclass quantification liquid chromatography-tandem mass spectrometry (LC-MS/MS) method, butyl methoxydibenzoylmethane (BMDM), 2,4-dihydroxybenzophenone (BP-1), benzophenone-3 (BP-3), benzophenone-4 (BP-4) and 2-ethyl-hexyl-4-trimethoxycinnamate (EHMC) were frequently (≥80%) detected in both influent and effluent with mean concentrations ranging from 23 to 1290 ng/L and 18-1018 ng/L, respectively; less than 2% of samples contained levels greater than 1000 ng/L. Higher concentrations of these frequently detected compounds were found during the wet/summer season, except for BP-4, which was the most abundant compound detected in all samples in terms of total mass. The target compounds behaved differently depending on the treatment level in WWTPs; overall, removal efficiencies were greater after secondary treatment when compared to primary treatment with >55% and compounds showing high removal (defined as >70% removal), respectively. Reverse osmosis was found to effectively eliminate UV filters from effluent (>99% removal). A preliminary risk assessment indicated that BP-3 and EHMC discharged from WWTPs may pose high risk to fishes in the local environment. Copyright © 2014 Elsevier Ltd. All rights reserved.

Systematic review: questionnaires for assessment of gastroesophageal reflux disease

NARCIS (Netherlands)

Bolier, E. A.; Kessing, B. F.; Smout, A. J.; Bredenoord, A. J.

2015-01-01

Numerous questionnaires with a wide variety of characteristics have been developed for the assessment of gastroesophageal reflux disease (GERD). Four well-defined dimensions are noticeable in these GERD questionnaires, which are symptoms, response to treatment, diagnosis, and burden on the quality

An integrated risk assessment tool for team-based periodontal disease management.

Science.gov (United States)

Thyvalikakath, Thankam P; Padman, Rema; Gupta, Sugandh

2013-01-01

Mounting evidence suggests a potential association of periodontal disease with systemic diseases such as diabetes, cardiovascular disease, cancer and stroke. The objective of this study is to develop an integrated risk assessment tool that displays a patients' risk for periodontal disease in the context of their systemic disease, social habits and oral health. Such a tool will be used by not just dental professionals but also by care providers who participate in the team-based care for chronic disease management. Displaying relationships between risk factors and its influence on the patient's general health could be a powerful educational and disease management tool for patients and clinicians. It may also improve the coordination of care provided by the provider-members of a chronic care team.

Identification and Progression of Heart Disease Risk Factors in Diabetic Patients from Longitudinal Electronic Health Records

Directory of Open Access Journals (Sweden)

Jitendra Jonnagaddala

2015-01-01

Full Text Available Heart disease is the leading cause of death worldwide. Therefore, assessing the risk of its occurrence is a crucial step in predicting serious cardiac events. Identifying heart disease risk factors and tracking their progression is a preliminary step in heart disease risk assessment. A large number of studies have reported the use of risk factor data collected prospectively. Electronic health record systems are a great resource of the required risk factor data. Unfortunately, most of the valuable information on risk factor data is buried in the form of unstructured clinical notes in electronic health records. In this study, we present an information extraction system to extract related information on heart disease risk factors from unstructured clinical notes using a hybrid approach. The hybrid approach employs both machine learning and rule-based clinical text mining techniques. The developed system achieved an overall microaveraged F-score of 0.8302.

A web-based team-oriented medical error communication assessment tool: development, preliminary reliability, validity, and user ratings.

Science.gov (United States)

Kim, Sara; Brock, Doug; Prouty, Carolyn D; Odegard, Peggy Soule; Shannon, Sarah E; Robins, Lynne; Boggs, Jim G; Clark, Fiona J; Gallagher, Thomas

2011-01-01

Multiple-choice exams are not well suited for assessing communication skills. Standardized patient assessments are costly and patient and peer assessments are often biased. Web-based assessment using video content offers the possibility of reliable, valid, and cost-efficient means for measuring complex communication skills, including interprofessional communication. We report development of the Web-based Team-Oriented Medical Error Communication Assessment Tool, which uses videotaped cases for assessing skills in error disclosure and team communication. Steps in development included (a) defining communication behaviors, (b) creating scenarios, (c) developing scripts, (d) filming video with professional actors, and (e) writing assessment questions targeting team communication during planning and error disclosure. Using valid data from 78 participants in the intervention group, coefficient alpha estimates of internal consistency were calculated based on the Likert-scale questions and ranged from α=.79 to α=.89 for each set of 7 Likert-type discussion/planning items and from α=.70 to α=.86 for each set of 8 Likert-type disclosure items. The preliminary test-retest Pearson correlation based on the scores of the intervention group was r=.59 for discussion/planning and r=.25 for error disclosure sections, respectively. Content validity was established through reliance on empirically driven published principles of effective disclosure as well as integration of expert views across all aspects of the development process. In addition, data from 122 medicine and surgical physicians and nurses showed high ratings for video quality (4.3 of 5.0), acting (4.3), and case content (4.5). Web assessment of communication skills appears promising. Physicians and nurses across specialties respond favorably to the tool.

The Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders: recruitment, assessment instruments, methods for the development of multicenter collaborative studies and preliminary results.

Science.gov (United States)

Miguel, Euripedes Constantino; Ferrão, Ygor Arzeno; Rosário, Maria Conceição do; Mathis, Maria Alice de; Torres, Albina Rodrigues; Fontenelle, Leonardo Franklin; Hounie, Ana Gabriela; Shavitt, Roseli Gedanke; Cordioli, Aristides Volpato; Gonzalez, Christina Hojaij; Petribú, Kátia; Diniz, Juliana Belo; Malavazzi, Dante Marino; Torresan, Ricardo C; Raffin, Andréa Litvin; Meyer, Elisabeth; Braga, Daniela T; Borcato, Sonia; Valério, Carolina; Gropo, Luciana N; Prado, Helena da Silva; Perin, Eduardo Alliende; Santos, Sandro Iêgo; Copque, Helen; Borges, Manuela Corrêa; Lopes, Angélica Prazeres; Silva, Elenita D da

2008-09-01

To describe the recruitment of patients, assessment instruments, implementation, methods and preliminary results of The Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders, which includes seven university sites. This cross-sectional study included a comprehensive clinical assessment including semi-structured interviews (sociodemographic data, medical and psychiatric history, disease course and comorbid psychiatric diagnoses), and instruments to assess obsessive-compulsive (Yale-Brown Obsessive-Compulsive Scale and Dimensional Yale-Brown Obsessive-Compulsive Scale), depressive (Beck Depression Inventory) and anxious (Beck Anxiety Inventory) symptoms, sensory phenomena (Universidade de São Paulo Sensory Phenomena Scale), insight (Brown Assessment Beliefs Scale), tics (Yale Global Tics Severity Scale) and quality of life (Medical Outcome Quality of Life Scale Short-form-36 and Social Assessment Scale). The raters' training consisted of watching at least five videotaped interviews and interviewing five patients with an expert researcher before interviewing patients alone. The reliability between all leaders for the most important instruments (Structured Clinical Interview for DSM-IV, Dimensional Yale-Brown Obsessive-Compulsive Scale, Universidade de São Paulo Sensory Phenomena Scale) was measured after six complete interviews. Inter-rater reliability was 96%. By March 2008, 630 obsessive-compulsive disorder patients had been systematically evaluated. Mean age (+/-SE) was 34.7 (+/-0.51), 56.3% were female, and 84.6% Caucasian. The most prevalent obsessive compulsive symptom dimensions were symmetry and contamination. The most common comorbidities were major depression, generalized anxiety and social anxiety disorder. The most common DSM-IV impulsive control disorder was skin picking. The sample was composed mainly by Caucasian individuals, unmarried, with some kind of occupational activity, mean age of 35 years, onset of obsessive

Validation of the "German Inflammatory Bowel Disease Activity Index (GIBDI)": An Instrument for Patient-Based Disease Activity Assessment in Crohn's Disease and Ulcerative Colitis.

Science.gov (United States)

Hüppe, Angelika; Langbrandtner, Jana; Häuser, Winfried; Raspe, Heiner; Bokemeyer, Bernd

2018-05-09

 Assessment of disease activity in Crohn's disease (CD) and ulcerative colitis (UC) is usually based on the physician's evaluation of clinical symptoms, endoscopic findings, and biomarker analysis. The German Inflammatory Bowel Disease Activity Index for CD (GIBDI CD ) and UC (GIBDI UC ) uses data from patient-reported questionnaires. It is unclear to what extent the GIBDI agrees with the physicians' documented activity indices.  Data from 2 studies were reanalyzed. In both, gastroenterologists had documented disease activity in UC with the partial Mayo Score (pMS) and in CD with the Harvey Bradshaw Index (HBI). Patient-completed GIBDI questionnaires had also been assessed. The analysis sample consisted of 151 UC and 150 CD patients. Kappa coefficients were determined as agreement measurements.  Rank correlations were 0.56 (pMS, GIBDI UC ) and 0.57 (HBI, GIBDI CD ), with p < 0.001. The absolute agreement for 2 categories of disease activity (remission yes/no) was 74.2 % (UC) and 76.6 % (CD), and for 4 categories (none/mild/moderate/severe) 60.3 % (UC) and 61.9 % (CD). The kappa values ranged between 0.47 for UC (2 categories) and 0.58 for CD (4 categories).  There is satisfactory agreement of GIBDI with the physician-documented disease activity indices. GIBDI can be used in health care research without access to assessments of medical practitioners. In clinical practice, the index offers a supplementary source of information. © Georg Thieme Verlag KG Stuttgart · New York.

Preliminary melter performance assessment report

International Nuclear Information System (INIS)

Elliott, M.L.; Eyler, L.L.; Mahoney, L.A.; Cooper, M.F.; Whitney, L.D.; Shafer, P.J.

1994-08-01

The Melter Performance Assessment activity, a component of the Pacific Northwest Laboratory's (PNL) Vitrification Technology Development (PVTD) effort, was designed to determine the impact of noble metals on the operational life of the reference Hanford Waste Vitrification Plant (HWVP) melter. The melter performance assessment consisted of several activities, including a literature review of all work done with noble metals in glass, gradient furnace testing to study the behavior of noble metals during the melting process, research-scale and engineering-scale melter testing to evaluate effects of noble metals on melter operation, and computer modeling that used the experimental data to predict effects of noble metals on the full-scale melter. Feed used in these tests simulated neutralized current acid waste (NCAW) feed. This report summarizes the results of the melter performance assessment and predicts the lifetime of the HWVP melter. It should be noted that this work was conducted before the recent Tri-Party Agreement changes, so the reference melter referred to here is the Defense Waste Processing Facility (DWPF) melter design

Disease state fingerprint for fall risk assessment.

Science.gov (United States)

Similä, Heidi; Immonen, Milla

2014-01-01

Fall prevention is an important and complex multifactorial challenge, since one third of people over 65 years old fall at least once every year. A novel application of Disease State Fingerprint (DSF) algorithm is presented for holistic visualization of fall risk factors and identifying persons with falls history or decreased level of physical functioning based on fall risk assessment data. The algorithm is tested with data from 42 older adults, that went through a comprehensive fall risk assessment. Within the study population the Activities-specific Balance Confidence (ABC) scale score, Berg Balance Scale (BBS) score and the number of drugs in use were the three most relevant variables, that differed between the fallers and non-fallers. This study showed that the DSF visualization is beneficial in inspection of an individual's significant fall risk factors, since people have problems in different areas and one single assessment scale is not enough to expose all the people at risk.

The internal consistency and validity of the Self-assessment Parkinson's Disease Disability Scale.

NARCIS (Netherlands)

Biemans, M.A.J.E.; Dekker, J.; Woude, L.H.V. van der

2001-01-01

OBJECTIVE: To test the consistency and validity of the Self-assessment Parkinson's Disease Disability Scale in patients with Parkinson's disease living at home. DESIGN: Patients with Parkinson's disease responded to a set of questionnaires. In addition, an observation of the performance of daily

Internal consistency and validity of the self-assessment Parkinson's Disease disability scale. Abstract.

NARCIS (Netherlands)

Dekker, J.; Biemans, M.A.J.E.; Woude, L.H.V. van der

2000-01-01

OBJECTIVE: To test the consistency and validity of the Self-assessment Parkinson's Disease Disability Scale in patients with Parkinson's disease living at home. DESIGN: Patients with Parkinson's disease responded to a set of questionnaires. In addition, an observation of the performance of daily

Preliminary assessment of the tritium inventory and permeation in the plasma facing components of ITER

International Nuclear Information System (INIS)

Federici, G.; Holland, D.; Brooks, J.; Causey, R.; Dolan, T.J.; Longhurst, G.

1995-01-01

This paper discusses preliminary quantitative predictions for the tritium inventory in- and permeation through the first-wall and divertor PFC's of ITER. The primary plasma facing material under consideration is beryllium, with possible use of tungsten or carbon fiber composites (CFC's) on high-heat-flux surfaces. They use state-of-the-art tritium transport models, in conjunction with design parameters, and loading conditions anticipated for the first-wall, baffle, limiter and divertor. The analysis includes the synergistic effects of erosion on tritium implantation and trapping, which are expected to play a key role, particularly in the divertor regions where the interaction of the plasma with the surfaces will be most severe. The influence of several key parameters that strongly affect tritium build-up and release is assessed. Finally, they discuss the uncertainties in materials properties under ITER operating conditions and the R and D needed to resolve these uncertainties

Identification and evaluation of areas of interest (AOIs): A screening tool for CERCLA preliminary assessments

International Nuclear Information System (INIS)

Autry, A.R.; Allen, K.L.; Smith, L.A.; Schumacher, J.; McDermott, M.

1994-01-01

A cost-effective alternative to the traditional Preliminary Assessment (PA) procedure is to identify and evaluate potential Areas of Interest (AOIs) that may become Comprehensive Environmental Response, Liability and Compensation Act of 1980 (CERCLA) sites prior to entry into Comprehensive Environmental Response, Liability Information System (CERCLIS) and the execution of a PA. AOIs would be identified by using much of the same methodology as would be used for site discovery in a CERCLA investigation, including aerial photograph review, reviews of building drawings, a limited review of historical records, and limited interviews and site visits. Once AOIs have been identified in this manner, decision criteria can be used to ascertain the regulatory status of the AOI and, based on regulatory guidance, whether the site should be considered for further investigation under CERCLA. This approach was used at Griffiss Air Force Base to identify 463 AOIs, where the primary problem was petroleum spills

Impact of PCA Strategies on Pain Intensity and Functional Assessment Measures in Adults with Sickle Cell Disease during Hospitalized Vaso-Occlusive Episodes

Science.gov (United States)

Dampier, Carlton D.; Wager, Carrie G.; Harrison, Ryan; Hsu, Lewis L.; Minniti, Caterina P.; Smith, Wally R.

2012-01-01

Clinical trials of sickle cell disease (SCD) pain treatment usually observe only small decrements in pain intensity during the course of hospitalization. Sub-optimal analgesic management and inadequate pain assessment methods are possible explanations for these findings. In a search for better methods for assessing inpatient SCD pain in adults, we examined several pain intensity and interference measures in both arms of a randomized controlled trial comparing two different opioid PCA therapies. Based upon longitudinal analysis of pain episodes, we found that scores from daily average Visual Analogue Scales (VAS) and several other measures, especially the Brief Pain Inventory (BPI), were sensitive to change in daily improvements in pain intensity associated with resolution of vaso-occlusive pain. In this preliminary trial, the low demand, high basal infusion (LDHI) strategy demonstrated faster, larger improvements in various measures of pain than the high demand, low basal infusion (HDLI) strategy for opioid PCA dosing, however, verification in larger studies is required. The measures and statistical approaches used in this analysis may facilitate design, reduce sample size, and improve analyses of treatment response in future SCD clinical trials of vaso-occlusive episodes. PMID:22886853

Preliminary structural assessment of DEMO vacuum vessel against a vertical displacement event

International Nuclear Information System (INIS)

Mozzillo, Rocco; Tarallo, Andrea; Marzullo, Domenico; Bachmann, Christian; Di Gironimo, Giuseppe; Mazzone, Giuseppe

2016-01-01

Highlights: • The paper focuses on a preliminary structural analysis of the current concept design of DEMO vacuum vessel. • The Vacuum Vessel was checked against the VDE in combinations with the weight force of all components that the vessel shall bear. • Different configurations for the vacuum vessel supports are considered, showing that the best solution is VV supported at the lower port. • The analyses evaluated the “P damage” according to RCC-MRx code. - Abstract: This paper focuses on a preliminary structural analysis of the current concept design of DEMO vacuum vessel (VV). The VV structure is checked against a vertical load due to a Vertical Displacement Event in combination with the weight force of all components that the main vessel shall bear. Different configurations for the supports are considered. Results show that the greatest safety margins are reached when the tokamak is supported through the lower ports rather than the equatorial ports, though all analyzed configurations are compliant with RCC-MRx design rules.

Preliminary structural assessment of DEMO vacuum vessel against a vertical displacement event

Energy Technology Data Exchange (ETDEWEB)

Mozzillo, Rocco, E-mail: rocco.mozzillo@unina.it [CREATE, University of Naples Federico II, DII, P.le Tecchio 80, 80125, Naples (Italy); Tarallo, Andrea; Marzullo, Domenico [CREATE, University of Naples Federico II, DII, P.le Tecchio 80, 80125, Naples (Italy); Bachmann, Christian [EUROfusion PMU, Boltzmannstraße 2, 85748 Garching (Germany); Di Gironimo, Giuseppe [CREATE, University of Naples Federico II, DII, P.le Tecchio 80, 80125, Naples (Italy); Mazzone, Giuseppe [Unità Tecnica Fusione - ENEA C.R. Frascati, Via E. Fermi 45, 00044 Frascati (Italy)

2016-11-15

Highlights: • The paper focuses on a preliminary structural analysis of the current concept design of DEMO vacuum vessel. • The Vacuum Vessel was checked against the VDE in combinations with the weight force of all components that the vessel shall bear. • Different configurations for the vacuum vessel supports are considered, showing that the best solution is VV supported at the lower port. • The analyses evaluated the “P damage” according to RCC-MRx code. - Abstract: This paper focuses on a preliminary structural analysis of the current concept design of DEMO vacuum vessel (VV). The VV structure is checked against a vertical load due to a Vertical Displacement Event in combination with the weight force of all components that the main vessel shall bear. Different configurations for the supports are considered. Results show that the greatest safety margins are reached when the tokamak is supported through the lower ports rather than the equatorial ports, though all analyzed configurations are compliant with RCC-MRx design rules.

Technologies Assessing Limb Bradykinesia in Parkinson's Disease.

Science.gov (United States)

Hasan, Hasan; Athauda, Dilan S; Foltynie, Thomas; Noyce, Alastair J

2017-01-01

The MDS-UPDRS (Movement Disorders Society - Unified Parkinson's Disease Rating Scale) is the most widely used scale for rating impairment in PD. Subscores measuring bradykinesia have low reliability that can be subject to rater variability. Novel technological tools can be used to overcome such issues. To systematically explore and describe the available technologies for measuring limb bradykinesia in PD that were published between 2006 and 2016. A systematic literature search using PubMed (MEDLINE), IEEE Xplore, Web of Science, Scopus and Engineering Village (Compendex and Inspec) databases was performed to identify relevant technologies published until 18 October 2016. 47 technologies assessing bradykinesia in PD were identified, 17 of which offered home and clinic-based assessment whilst 30 provided clinic-based assessment only. Of the eligible studies, 7 were validated in a PD patient population only, whilst 40 were tested in both PD and healthy control groups. 19 of the 47 technologies assessed bradykinesia only, whereas 28 assessed other parkinsonian features as well. 33 technologies have been described in additional PD-related studies, whereas 14 are not known to have been tested beyond the pilot phase. Technology based tools offer advantages including objective motor assessment and home monitoring of symptoms, and can be used to assess response to intervention in clinical trials or routine care. This review provides an up-to-date repository and synthesis of the current literature regarding technology used for assessing limb bradykinesia in PD. The review also discusses the current trends with regards to technology and discusses future directions in development.

Physiological assessment of sensitivity of noninvasive testing for coronary artery disease

International Nuclear Information System (INIS)

Simonetti, I.; Rezai, K.; Rossen, J.D.; Winniford, M.D.; Talman, C.L.; Hollenberg, M.; Kirchner, P.T.; Marcus, M.L.

1991-01-01

The sensitivity of three noninvasive tests for coronary artery disease was assessed by means of quantitative indexes of disease severity in three different groups of patients. The overall population consisted of 110 subjects with limited coronary artery disease and no myocardial infarction. Planar dipyridamole- 201 Tl scintigraphy was evaluated in 31 patients, computer-assisted exercise treadmill in 28, and high-dose dipyridamole echocardiography testing in 51. Sensitivity was assessed by rigorous gold standards to define disease severity, such as measurement of minimum cross-sectional area and percent area of stenosis, by quantitative computerized coronary angiography (Brown/Dodge method). On the basis of the results of previous studies, the presence of physiologically significant coronary artery disease was indicated by a stenotic minimum cross-sectional area (MCSA) of less than 2.0 mm 2 or a greater than 75% area of stenosis. With MCSA as the gold standard, dipyridamole- 201 Tl scintigraphy, computerized exercise treadmill, and dipyridamole echocardiography testing showed sensitivities of 52%, 54%, and 61%, respectively, in the three different patient cohorts enrolled. With percent area of stenosis as the gold standard, the sensitivity figures obtained for dipyridamole- 201 Tl, computerized exercise treadmill, and dipyridamole echocardiography testing were 64%, 54%, and 69%, respectively. For each of the three tests, sensitivity increased with increasing lesion severity. Sensitivity was also better in patients with left anterior descending coronary (LAD) disease when compared with patients with left circumflex or right coronary artery disease. Results of these studies demonstrate that in patients with limited coronary artery disease none of the tests evaluated is definitely superior in sensitivity

APACHE II SCORING SYSTEM AND ITS MODIFICATION FOR THE ASSESSMENT OF DISEASE SEVERITY IN CHILDREN WHO UNDERWENT POLYCHEMOTHERAPY

Directory of Open Access Journals (Sweden)

А. V. Sotnikov

2014-01-01

Full Text Available Short-term disease prognosis should be considered for the appropriate treatment policy based on the assessment of disease severity in patients with acute disease. The adequate assessment of disease severity and prognosis allows the indications for transferring patients to the resuscitation and intensive care department to be defined more precisely. Disease severity of patients who underwent polychemotherapy was assessed using APACHE II scoring system.

A preliminary assessment of individual doses in the environs of Berkeley, Gloucestershire, following the Chernobyl nuclear reactor accident

International Nuclear Information System (INIS)

Nair, S.; Darley, P.J.

1986-06-01

A preliminary assessment has been made of the individual doses to critical group members of the public in the environs of Berkeley arising from fallout resulting from the Chernobyl accident. The assessment was based on measurements of airborne radionuclide concentrations, ground deposition and nuclide concentrations in rainwater, tapwater, grass, milk and green vegetables. The committed effective dose-equivalent was found to be as follows:- Adult - 200 μSv, 1 year old child - 500 μSv, the 10 year old child receiving a dose intermediate between these two values. The estimate accounts only for the nuclides measured and the specific exposure routes considered namely ingestion of milk and vegetables, inhalation and external exposure. However, it is believed that the inclusion of a range of other nuclides of potential significance, which may have been present but not measured, and potential intakes from additional routes is unlikely to increase the above estimates by more than a factor of 2. (author)

An Early Years Toolbox for Assessing Early Executive Function, Language, Self-Regulation, and Social Development: Validity, Reliability, and Preliminary Norms.

Science.gov (United States)

Howard, Steven J; Melhuish, Edward

2017-06-01

Several methods of assessing executive function (EF), self-regulation, language development, and social development in young children have been developed over previous decades. Yet new technologies make available methods of assessment not previously considered. In resolving conceptual and pragmatic limitations of existing tools, the Early Years Toolbox (EYT) offers substantial advantages for early assessment of language, EF, self-regulation, and social development. In the current study, results of our large-scale administration of this toolbox to 1,764 preschool and early primary school students indicated very good reliability, convergent validity with existing measures, and developmental sensitivity. Results were also suggestive of better capture of children's emerging abilities relative to comparison measures. Preliminary norms are presented, showing a clear developmental trajectory across half-year age groups. The accessibility of the EYT, as well as its advantages over existing measures, offers considerably enhanced opportunities for objective measurement of young children's abilities to enable research and educational applications.

An ethical assessment model for digital disease detection technologies.

Science.gov (United States)

Denecke, Kerstin

2017-09-20

Digital epidemiology, also referred to as digital disease detection (DDD), successfully provided methods and strategies for using information technology to support infectious disease monitoring and surveillance or understand attitudes and concerns about infectious diseases. However, Internet-based research and social media usage in epidemiology and healthcare pose new technical, functional and formal challenges. The focus of this paper is on the ethical issues to be considered when integrating digital epidemiology with existing practices. Taking existing ethical guidelines and the results from the EU project M-Eco and SORMAS as starting point, we develop an ethical assessment model aiming at providing support in identifying relevant ethical concerns in future DDD projects. The assessment model has four dimensions: user, application area, data source and methodology. The model supports in becoming aware, identifying and describing the ethical dimensions of DDD technology or use case and in identifying the ethical issues on the technology use from different perspectives. It can be applied in an interdisciplinary meeting to collect different viewpoints on a DDD system even before the implementation starts and aims at triggering discussions and finding solutions for risks that might not be acceptable even in the development phase. From the answers, ethical issues concerning confidence, privacy, data and patient security or justice may be judged and weighted.

Preliminary remediation goals for ecological endpoints

International Nuclear Information System (INIS)

Efroymson, R.A.; Suter, G.W. II; Sample, B.E.; Jones, D.S.

1996-07-01

Preliminary remediation goals (PRGs) are useful for risk assessment and decision making at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) sites. PRGs are upper concentration limits for specific chemicals in specific environmental media that are anticipated to protect human health or the environment. They can be used for multiple remedial investigations at multiple facilities. In addition to media and chemicals of potential concern, the development of PRGs generally requires some knowledge or anticipation of future land use. In Preliminary Remediation Goals for Use at the U.S. Department of Energy Oak Ridge Operations Office (Energy Systems 1995), PRGs intended to protect human health were developed with guidance from Risk Assessment Guidance for Superfund: Volume I - Human Health Evaluation Manual, Part B (RAGS) (EPA 1991). However, no guidance was given for PRGs based on ecological risk. The numbers that appear in this volume have, for the most part, been extracted from toxicological benchmarks documents for Oak Ridge National Laboratory (ORNL) and have previously been developed by ORNL. The sources of the quantities, and many of the uncertainties associated with their derivation, are described in this technical memorandum

Preliminary remediation goals for ecological endpoints

International Nuclear Information System (INIS)

Efroymson, R.A.; Suter, G.W. II.

1995-09-01

Preliminary remediation goals (PRGs) are useful for risk assessment and decision making at Comprehensive Environmental Response, compensation, and Liability Act (CERCLA) sites. PRGs are upper concentration limits for specific chemicals in specific environmental media that are anticipated to protect human health or the environment. They can be used for multiple remedial investigations at multiple facilities. In addition to media and chemicals of potential concern, the development of PRGs generally requires some knowledge or anticipation of future land use. In Preliminary Remediation Goals for Use at the US Department of Energy Oak Ridge Operations Office (Energy Systems 1995), PRGs intended to protect human health were developed with guidance from Risk Assessment Guidance for Superfund: Volume I-Human Health Evaluation Manual, Part B (RAGS) (EPA 1991). However, no guidance was given for PRGs based on ecological risk. The numbers that appear in this volume have, for the most part, been extracted from toxicological benchmarks documents for Oak Ridge National Laboratory (ORNL) and have previously been developed by ORNL. The sources of the quantities, and many of the uncertainties associated with their derivation, are described in this technical memorandum

Preliminary assessment of the environmental and health impacts of nuclear and coal fuel cycles

International Nuclear Information System (INIS)

Yang Yin; Chen Zhuzhou; Pan Ziqiang

1992-01-01

The paper reports on the environmental impacts and health effects of coal and nuclear fuel cycles in China. Data of interest for China are presented in a comparative manner; epidemiological investigations in Shanxi province indicate that the incidences of chronic pulmonary diseases and infant cogenital malformation were apparently increased over the fall-out areas of coal-fired power stations and coal mines. The authors outline the framework of a research project on environmental assessment of nuclear energy and other energy systems. The main features of the project are: environmental and health impacts of coal and nuclear fuel cycles, environmental impact assessment of coal transportation, cost accounting of nuclear and other energy sources, health risk assessment. (author). 24 refs, 4 tabs

Preliminary assessment of trace elements effects on essential oil production of Melissa officinalis L. (Lemon balm)

International Nuclear Information System (INIS)

Sussa, Fabio V.; Duarte, Celina L.; Andrade, Luana S.; Silva, Paulo S.C.; Furlan, Marcos R.

2013-01-01

Melissa officinalis L., Lemon balm, (Lamiaceae) is an herb used as medicine, condiment and in the cosmetic and perfumery industry due to its essential oil. In this study a preliminary assessment of trace elements effects on essential oil production was performed in order to verify an improvement in its quality. The Melissa officinalis samples were harvested from three different soil sites localized in Ibirapuera Park, São Paulo, Brazil. Elemental concentration for the elements As, Ba, Br, Ce, Cl, Co, Cr, Cs, Eu, Fe, Hf, K, La, Lu, Mg, Mn, Na, Nd, Rb, Sb, Sc, Se, Sm, Ta, Tb, Ti, Th, U, V, Yb, Zn and Zr was determined by Instrumental Neutron Activation Analysis (INAA) in Melissa officinalis leaves and surrounding soil. The essential oil was extracted from its leaves by hydrodistillation process in Clevenger apparatus and analyzed by gas chromatography coupled to a mass spectrometer (GC-MS). Certified reference materials NIST SRM-1515 Apple Leaves, NIST SRM-1547 Peach Leaves and NIST SRM-1573a Tomato Leaves were analyzed for quality control. Our results showed Geranial and Neral were identified as the major compounds in the essential oil extracted from Melissa officinalis L. for all collected sites. However, the relative proportion of some chemical constituents was altered according to the site collected. The preliminary results showed that the production of essential oil by Melissa officinalis must be positively correlated with the concentrations of Rb, Zn and negatively correlated with Sc, Mn, La, K, Fe, and Cr. (author)

Preliminary assessment of trace elements effects on essential oil production of Melissa officinalis L. (Lemon balm)

Energy Technology Data Exchange (ETDEWEB)

Sussa, Fabio V.; Duarte, Celina L.; Andrade, Luana S.; Silva, Paulo S.C., E-mail: pscsilva@ipen.br, E-mail: clduarte@ipen.br, E-mail: fabiosussa@uol.com.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Furlan, Marcos R., E-mail: furlanagro@gmail.com [Universidade de Taubate, SP (Brazil). Departamento de Ciencias Agrarias

2013-07-01

Melissa officinalis L., Lemon balm, (Lamiaceae) is an herb used as medicine, condiment and in the cosmetic and perfumery industry due to its essential oil. In this study a preliminary assessment of trace elements effects on essential oil production was performed in order to verify an improvement in its quality. The Melissa officinalis samples were harvested from three different soil sites localized in Ibirapuera Park, São Paulo, Brazil. Elemental concentration for the elements As, Ba, Br, Ce, Cl, Co, Cr, Cs, Eu, Fe, Hf, K, La, Lu, Mg, Mn, Na, Nd, Rb, Sb, Sc, Se, Sm, Ta, Tb, Ti, Th, U, V, Yb, Zn and Zr was determined by Instrumental Neutron Activation Analysis (INAA) in Melissa officinalis leaves and surrounding soil. The essential oil was extracted from its leaves by hydrodistillation process in Clevenger apparatus and analyzed by gas chromatography coupled to a mass spectrometer (GC-MS). Certified reference materials NIST SRM-1515 Apple Leaves, NIST SRM-1547 Peach Leaves and NIST SRM-1573a Tomato Leaves were analyzed for quality control. Our results showed Geranial and Neral were identified as the major compounds in the essential oil extracted from Melissa officinalis L. for all collected sites. However, the relative proportion of some chemical constituents was altered according to the site collected. The preliminary results showed that the production of essential oil by Melissa officinalis must be positively correlated with the concentrations of Rb, Zn and negatively correlated with Sc, Mn, La, K, Fe, and Cr. (author)

Preliminary Assessment of Spatial Competition in the Market for E85: Presentation Supplement

Energy Technology Data Exchange (ETDEWEB)

Clinton, Bentley [National Renewable Energy Lab. (NREL), Golden, CO (United States); Johnson, Caley [National Renewable Energy Lab. (NREL), Golden, CO (United States); Moriarty, Kristi [National Renewable Energy Lab. (NREL), Golden, CO (United States); Newes, Emily [National Renewable Energy Lab. (NREL), Golden, CO (United States); Vimmerstedt, Laura [National Renewable Energy Lab. (NREL), Golden, CO (United States)

2017-02-01

The Preliminary Assessment of Spatial Competition in the Market for E85 presentation and supplementary report from the U.S. Department of Energy’s National Renewable Energy Laboratory examine how the spacing of E85 fueling stations impacts E85 retail pricing. The analysis finds an inverse correlation between station density and E85 prices, with local competition putting downward pressure on E85 prices. A gas station with E85 whose nearest competitor is within a 0.5 mile radius is associated with a lower E85 price per gallon than an otherwise identical station with E85 whose nearest competitor is farther away. The analysis also finds a higher level of correlation between E85 and both E10 and wholesale gasoline prices than with ethanol costs. This indicates that E85 may, in fact, be priced with respect to its substitute fuel, and not based on the cost of its inputs. These findings help identify key trends and barriers in E85 markets and highlight data gaps that, if addressed, could help enable competitive E85 markets. The analysis was released in February 2017 and uses national and Minnesota-specific price data.

A longitudinal assessment of periodontal disease in 52 Miniature Schnauzers.

Science.gov (United States)

Marshall, Mark D; Wallis, Corrin V; Milella, Lisa; Colyer, Alison; Tweedie, Andrew D; Harris, Stephen

2014-09-01

Periodontal disease (PD) is the most widespread oral disease in dogs and has been associated with serious systemic diseases. The disease is more prevalent in small breeds compared to large breeds and incidence increases with advancing age. In prevalence studies 84% of Beagles over the age of 3 and 100% of Poodles over the age of 4 were diagnosed with PD. Current knowledge of the rate of progression of PD is limited. The objective of this study was to determine the rate of PD progression in Miniature Schnauzers, an at risk small breed of dog. Dogs (n = 52, age 1.3-6.9 years) who had received a regular oral care regime prior to this study were assessed for levels of gingivitis and periodontitis around the whole gingival margin in every tooth under general anaesthetic. Assessments were conducted approximately every six weeks for up to 60 weeks following the cessation of the oral care regime. All of the 2155 teeth assessed entered the study with some level of gingivitis. 23 teeth entered the study with periodontitis, observed across 12 dogs aged between 1.3 and 6.9 years. 35 dogs had at least 12 teeth progress to periodontitis within 60 weeks. Of the teeth that progressed to periodontitis, 54% were incisors. The lingual aspect of the incisors was significantly more likely to be affected (p periodontitis-affected teeth was variable with 24% of the aspects affected having very mild gingivitis, 36% mild gingivitis and 40% moderate gingivitis. Periodontitis progression rate was significantly faster in older dogs. Only one dog (age 3.5) did not have any teeth progress to periodontitis after 60 weeks. This is the first study to have assessed the progression rate of periodontitis in Miniature Schnauzers and highlights that with no oral care regime, the early stages of periodontitis develop rapidly in this breed. An oral care regime and twice yearly veterinary dental health checks should be provided from an early age for this breed and other breeds with similar

Preliminary assessment of modified borosilicate glasses for chromium and ruthenium immobilization

Energy Technology Data Exchange (ETDEWEB)

Farid, Osama M. [Reactors Department, Nuclear Research Center, Atomic Energy Authority of Egypt, P.O. 13759, Inshas, Cairo (Egypt); Centre of Nuclear Engineering (CNE), Department of Materials, Imperial College London, London, SW7 2BP (United Kingdom); Abdel Rahman, R.O., E-mail: alaarehab@yahoo.com [Hot Laboratory Center, Atomic Energy Authority of Egypt, P.O. 13759, Inshas, Cairo (Egypt)

2017-01-15

The feasibility of using modified alkali borosilicate glasses for ruthenium and chromium immobilization is preliminary assessed by investigating the immobilization system structure under normal conditions. Within this context, reference alkali borosilicate, and simulated Magnox-modified glasses were prepared and studied. The results indicate that ruthenium is immobilized in the vitreous structure as encapsulated RuO{sub 2} crystallites that act as seeds for heterogeneous nucleation of other crystalline phases. The presence of Zn, as modifier, has contributed to chromium immobilization in zincochromite spinel structure, whereas Ca is accommodated in the vitreous structure. Immobilization performance was evaluated by conducting conservative static leach test and studying the leached glass. Leached glass morphology was altered, where near surface reference glass is leached over 400 nm and simulated Magnox-modified sample is altered over 300 nm. Normalized release rates are within normal range for borosilicate material. For simulated Magnox-modified sample, Ca and alkali structural element, i.e. Na and Li, are leached via ion-exchange reaction. The ion-exchanged fraction equals 1.06 × 10{sup −8} mol/m{sup 2} s and chromium has slightly lower normalized release rate value than ruthenium. - Highlights: • The presence of modifiers and waste oxides led to localized de-vitrification. • Ruthenium is encapsulated within the vitreous glass network as RuO{sub 2} crystals. • Chromium is immobilized within the zincochromite spinel structure. • Pitting and cracks induced by leaching did not affect the immobilization performance.

A preliminary assessment of financial stability, efficiency, health systems and health outcomes using performance-based contracts in Belize.

Science.gov (United States)

Bowser, Diana M; Figueroa, Ramon; Natiq, Laila; Okunogbe, Adeyemi

2013-01-01

Over the last 10 years, Belize has implemented a National Health Insurance (NHI) program that uses performance-based contracts with both public and private facilities to improve financial sustainability, efficiency and service provision. Data were collected at the facility, district and national levels in order to assess trends in financial sustainability, efficiency payments, year-end bonuses and health system and health outcomes. A difference-in-difference approach was used to assess the difference in technical efficiency between private and public facilities. The results show that per capita spending on services provided by the NHI program has decreased over the period 2006-2009 from BZ$177 to BZ$136. The private sector has achieved higher levels of technical efficiency, but lower percentages of efficiency and year-end bonus payments. Districts with contracts through the NHI program showed greater improvements in facility births, nurse density, reducing maternal mortality, diabetes deaths and morbidity from bronchitis, emphysema and asthma than districts without contracts over the period 2006-2010. This preliminary assessment of Belize's pay-for-performance system provides some positive results, however further research is needed to use the lessons learned from Belize to implement similar reforms in other systems.

Correlation of Gastroesophageal reflux disease Assessment Symptom Questionnaire to impedance-pH measurements in children

OpenAIRE

Prachuapthunyachart, Sittichoke; Jarasvaraparn, Chaowapong; Gremse, David A

2017-01-01

Background: Esophageal multichannel intraluminal impedance-pH monitoring has become one of the preferred tests to correlate observed reflux-like behaviors with esophageal reflux events. The Gastroesophageal reflux disease Assessment Symptom Questionnaire is a validated tool used to distinguish infants with gastroesophageal reflux disease from healthy children. The aim of this study was to determine whether the Gastroesophageal reflux disease Assessment Symptom Questionnaire composite symptom ...

RAPID3 scores and hand outcome measurements in RA patients: a preliminary study.

Science.gov (United States)

Qorolli, Merita; Hundozi-Hysenaj, Hajrije; Rexhepi, Sylejman; Rehxepi, Blerta; Grazio, Simeon

2017-06-01

The Routine Assessment of Patient Index Data 3 (RAPID3) is a patient-reported disease activity measure used to assess physical function, pain, and global health in patients with rheumatoid arthritis (RA) without formal joint counts. Since hand involvement and its decreased function are hallmarks of RA, the aim of our study was to investigate the performance of RAPID3 scores with regard to hand function and to confirm previous findings that the RAPID3 score as a disease activity measure is strongly correlated with the DAS28 score. Sixty-eight consecutive patients with RA (85% female), aged 18-75 years, were included in the study and were recruited during their outpatient visit. Apart from demographic and clinical data, the obtained parameters of interest included RAPID3 scores and assessments of the function of the hand, namely, the signal of functional impairment (SOFI)-hand, grip strength, and pulp-to-palm distance, as well the Health Assessment Questionnaire- Disability Index (HAQ-DI) and DAS28 scores. Pearson's correlation coefficient, Student's t test and linear regression were used in the statistical analysis of the results. The significance was set to p < 0.05. A positive correlation was found between RAPID3 scores and HAQ-DI scores, SOFI-hand scores, and pulp-to-palm distance, and negative correlation was observed between RAPID3 scores and grip strength. The order regarding the strength of correlations between RAPID3 scores and other variables (from the strongest to the weakest) was as follows: HAQ-DI, grip strength, SOFI-hand and pulp-to-palm distance. The hand assessment variables had stronger correlations with RAPID3 scores than with DAS28 scores. Our preliminary study showed that RAPID3 scores were strongly correlated with measurements of the functional ability of the hand, demonstrating that RAPID3 can be used as a measure of disease activity in clinical practice and to characterize hand function. Further studies are needed to confirm this result.

Preliminary assessment of partitioning and transmutation as a radioactive waste management concept

International Nuclear Information System (INIS)

Croff, A.G.; Tedder, D.W.; Drago, J.P.; Blomeke, J.O.; Perona, J.J.

1977-09-01

Partitioning (separating) the actinide elements from nuclear fuel cycle wastes and transmuting (burning) them to fission products in power reactors represents a potentially advanced concept of radioactive waste management which could reduce the long-term (greater than 1000 years) risk associated with geologic isolation of wastes. The greatest uncertainties lie in the chemical separations technology needed to recover greater than 99 percent of the actinides during the reprocessing of spent fuels and their refabrication as fresh fuels or target elements. Preliminary integrated flowsheets based on modifications of the Purex process and supplementary treatment by oxalate precipitation and ion exchange indicate that losses of plutonium in reprocessing wastes might be reduced from about 2.0 percent to 0.1 percent, uranium losses from about 1.7 percent to 0.1 percent, neptunium losses from 100 percent to about 1.2 percent, and americium and curium from 100 percent to about 0.5 percent. Mixed oxide fuel fabrication losses may be reduced from about 0.5 percent to 0.06 percent for plutonium and from 0.5 percent to 0.04 percent for uranium. Americium losses would be about 5.5 percent for the reference system. Transmutation of the partitioned actinides at a rate of 5 to 7 percent per year is feasible in both fast and thermal reactors, but additional studies are needed to determine the most suitable strategy for recycling them to reactors and to assess the major impacts of implementing the concept on fuel cycle operations and costs. It is recommended that the ongoing program to evaluate the feasibility, impacts, costs, and incentives of implementing partitioning-transmutation be continued until a firm assessment of its potentialities can be made. At the present level of effort, achievement of this objective should be possible by 1980. 27 tables, 50 figures

A preliminary parametric performance assessment for the disposal of alpha-contaminated mixed low-level waste stored at the Idaho National Engineering Laboratory

International Nuclear Information System (INIS)

Smith, T.H.; Anderson, G.L.; Myers, J.

1995-01-01

A preliminary parametric performance assessment (PA) has been performed of potential waste disposal systems for alpha-contaminated mixed low-level waste (ALLW) currently stored at the Idaho National Engineering Laboratory. The radionuclide-confinement performance of treated ALLW in various final waste forms, in various disposal locations, and under various assumptions was evaluated. Compliance with performance objectives was assessed for the undisturbed waste scenario and for intrusion scenarios. Some combinations of final waste form, disposal site, and environmental transport assumptions lead to calculated does that comply with the performance objectives, while others do not. The results will help determine the optimum degree of ALLW immobilization to satisfy the performance objectives while minimizing cost

Preliminary assessment of fluorine-18 fluorodeoxyglucose positron emission tomography in patients with bladder cancer

International Nuclear Information System (INIS)

Kosuda, S.; Kison, P.V.; Greenough, R.; Grossman, H.B.; Wahl, R.L.

1997-01-01

The purpose of this study was to assess the feasibility of imaging of bladder cancer with fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) scanning. We studied 12 patients with histologically proven bladder cancer who had undergone surgical procedures and/or radiotherapy. Retrograde irrigation of the urinary bladder with 1000-3710 ml saline was performed during nine of the studies. Dynamic and static PET images were obtained, and standardized uptake value images were reconstructed. FDG-PET scanning was true-positive in eight patients (66.7%), but false-negative in four (33.3%). Of 20 organs with tumor mass lesions confirmed pathologically or clinically, 16 (80%) were detected by FDG-PET scanning. FDG-PET scanning detected all of 17 distant metastatic lesions and two of three proven regional lymph node metastases. FDG-PET was also capable of differentiating viable recurrent bladder cancer from radiation-induced alterations in two patients. In conclusion, these preliminary data indicate the feasibility of FDG-PET imaging in patients with bladder cancer, although a major remaining pitfall is intense FDG accumulation in the urine. (orig.). With 3 figs., 1 tab

Diffusion-weighted MR imaging of cystic lesions of neurocysticercosis: a preliminary study

International Nuclear Information System (INIS)

Raffin, Luciana S.; Bacheschi, Luiz A.; Machado, Luis R.; Nobrega, Jose P.S.; Coelho, Christina; Leite, Claudia C.

2001-01-01

Neurocysticercosis is an endemic disease in some developing countries. It has pleomorfic clinical and imaging findings, which are variable from patient to patient. In this preliminary note, we studied the magnetic resonance diffusion-weighted images of sixteen patients presenting with cystic lesions of this disease diagnosed by clinical and laboratorial findings. All the lesions had hypointense signal and the similar apparent diffusion coefficient values as the cerebrospinal fluid. (author)

Lockheed Martin T-Rex: Preliminary report

International Nuclear Information System (INIS)

1997-01-01

T-Rex is a robot which may be used in toxic or flammable environments. The assessment of the T-Rex conducted at the Lockheed Martin facility was limited in its scope. The scope of the assessment was directed by the type of equipment being used and the amount of accessibility to the equipment. Due to severe time constraints--the assessment was conducted in one day--human factors interface activities were limited. This should be considered a preliminary assessment. This report covers aspects of the technology that were available to the assessment team. Recommendations for future evaluation of this technology are also included. The contents are as follows: Electrical Considerations; General Electrical Consideration; Trailing Cables; Grounding; Surface High Voltage Distribution; Low and Medium Voltage Alternating Current Circuits; Potential for Harmful Human Factor Incidents and Enterprise Disablement; Exclusion Zone Emergency Maintenance; and Recommendations

Preliminary waste acceptance requirements - Konrad repository project

International Nuclear Information System (INIS)

Brennecke, P.W.; Warnecke, E.H.

1991-01-01

In Germany, the planned Konrad repository is proposed for the disposal of all types of radioactive wastes whose thermal influence upon the host rock is negligible. The Bundesamt fuer Strahlenschutz has established Preliminary Waste Acceptance Requirements (as of April 1990) for this facility. The respective requirements were developed on the basis of the results of site-specific safety assessments. They include general requirements on the waste packages to be disposed of as well as more specific requirements on the waste forms, the packaging and the radionuclide inventory per waste package. In addition, the delivery of waste packages was regulated. An outline of the structure and the elements of the Preliminary Waste Acceptance Requirements of April 1990 is given including comments on their legal status. (Author)

An inventory to assess empathic concern for disability and accessibility: development and preliminary psychometric investigation

Directory of Open Access Journals (Sweden)

Motohide Miyahara

2017-11-01

Full Text Available Cultivating empathy and prosocial attitude towards disability is a first step for university students to become the leaders of society and professions to create accessible environments and inclusive society. Gauging levels of empathy and prosocial attitude towards disability among the students is important for evaluating the adequacy of disability training and education. We developed and conducted an initial psychometric validation of a novel inventory in Japanese and English languages to assess Empathic Concern for Disability and Accessibility (ECDA in Japan and New Zealand. Preliminary psychometric evaluation indicates strong internal consistency in the Japanese sample (α = .96 and the New Zealand sample (α = .93. Exploratory factor analysis demonstrated a four-factor solution for both samples. The present study has resulted in the development of the ECDA that demonstrated initial support for internal consistency and construct validity. The ECDA may be used for the cross-cultural comparisons of disability training and education.

Semantic Feature Training for the Treatment of Anomia in Alzheimer Disease: A Preliminary Investigation.

Science.gov (United States)

Flanagan, Kieran J; Copland, David A; van Hees, Sophia; Byrne, Gerard J; Angwin, Anthony J

2016-03-01

This is a preliminary investigation into the effectiveness of semantic feature training for the treatment of anomia in Alzheimer disease (AD). Anomia is a common clinical characteristic of AD. It is widely held that anomia in AD is caused by the combination of cognitive deficits and progressive loss of semantic feature information. Therapy that aims to help participants relearn or retain semantic features should, therefore, help treat anomia in AD. Two men with AD and one man with progressive nonfluent aphasia received 10 treatment sessions focused on relearning the names of 20 animals and 20 fruits. Within each category, half of the items were of high and half were of low typicality. We individualized treatment items to each participant, using items that each had not named correctly at baseline. Treatment sessions consisted of naming, category sorting, and semantic feature verification tasks. Both participants with AD showed post-treatment improvements in naming, and one maintained the treatment effects at 6-week follow-up. The semantic category of the treatment items influenced post-treatment outcomes, but typicality did not. In contrast to the participants with AD, the man with progressive nonfluent aphasia had no improvement in naming ability. Our results suggest the potential viability of semantic feature training to treat anomia in AD and, therefore, the need for further research.

Yucca Mountain transportation routes: Preliminary characterization and risk analysis

International Nuclear Information System (INIS)

Souleyrette, R.R. II; Sathisan, S.K.; di Bartolo, R.

1991-01-01

This report presents appendices related to the preliminary assessment and risk analysis for high-level radioactive waste transportation routes to the proposed Yucca Mountain Project repository. Information includes data on population density, traffic volume, ecologically sensitive areas, and accident history

An assessment of psychiatric disturbances in graves disease in a ...

African Journals Online (AJOL)

An assessment of psychiatric disturbances in graves disease in a medical college in eastern India. ... standard error of difference, the chi-square test, and paired Student's T-test. ... The common symptoms were insomnia, irritability, and anxiety.

Comparative assessment of the prevalence of periodontal disease in subjects with and without systemic autoimmune diseases: A case-control study.

Science.gov (United States)

Ramesh Kumar, S G; Aswath Narayanan, M B; Jayanthi, D

2016-01-01

Immune mechanism shares a common pathway both for systemic autoimmune diseases and periodontal diseases. Scientific exploration of literature revealed limited studies on the association between systemic autoimmune diseases and periodontal diseases in India. The aim of the study is to find whether the presence of systemic autoimmune diseases in an individual is a risk factor for the development of periodontal disease. This was a hospital-based case-control study. A sample of 253 patients with systemic autoimmune diseases, attending the Rheumatology Department of Government General Hospital, Chennai-3, and 262 patients without systemic autoimmune diseases, attending the outpatient department of the Tamil Nadu Government Dental College and Hospital, Chennai-3, constituted the case and control groups, respectively. Age, gender, and oral hygiene status matching was done. Oral hygiene status was assessed using oral hygiene index (OHI) and periodontal status was assessed using community periodontal index (CPI) and loss of attachment (LOA) index. Statistical analysis was done using SPSS version 15 (SPSS Inc, 2006, Chicago). Results showed 99.2% and 73.9% prevalence of gingivitis and periodontitis, respectively, in the case group as compared to 85.5% and 14.9%, respectively, in the control group. There is no linear relationship between OHI scores and prevalence of periodontitis (CPI and LOA scores) in the case group. Patients suffering from systemic autoimmune diseases showed more prevalence of periodontal diseases irrespective of oral hygiene scores. It is postulated that the presence of systemic autoimmune diseases may pose a risk for the development of periodontal diseases.

Neuropsychological assessment of driving safety risk in older adults with and without neurologic disease.

Science.gov (United States)

Anderson, Steven W; Aksan, Nazan; Dawson, Jeffrey D; Uc, Ergun Y; Johnson, Amy M; Rizzo, Matthew

2012-01-01

Decline in cognitive abilities can be an important contributor to the driving problems encountered by older adults, and neuropsychological assessment may provide a practical approach to evaluating this aspect of driving safety risk. The purpose of the present study was to evaluate several commonly used neuropsychological tests in the assessment of driving safety risk in older adults with and without neurological disease. A further goal of this study was to identify brief combinations of neuropsychological tests that sample performances in key functional domains and thus could be used to efficiently assess driving safety risk. A total of 345 legally licensed and active drivers over the age of 50, with no neurologic disease (N = 185), probable Alzheimer's disease (N = 40), Parkinson's disease (N = 91), or stroke (N = 29), completed vision testing, a battery of 10 neuropsychological tests, and an 18-mile drive on urban and rural roads in an instrumented vehicle. Performances on all neuropsychological tests were significantly correlated with driving safety errors. Confirmatory factor analysis was used to identify 3 key cognitive domains assessed by the tests (speed of processing, visuospatial abilities, and memory), and several brief batteries consisting of one test from each domain showed moderate corrected correlations with driving performance. These findings are consistent with the notion that driving places demands on multiple cognitive abilities that can be affected by aging and age-related neurological disease, and that neuropsychological assessment may provide a practical off-road window into the functional status of these cognitive systems.

Determining transition readiness in congenital heart disease: Assessing the utility of the Transition Readiness Questionnaire

Science.gov (United States)

The Transition Readiness Assessment Questionnaire (TRAQ) is a tool commonly used to assess transition readiness in adolescents with chronic diseases. It was previously validated in youth with special health care needs (YSHCN), but no patients with congenital heart disease (CHD) were included in the ...

Assessing peridomestic entomological factors as predictors for Lyme disease

Science.gov (United States)

Connally, N.P.; Ginsberg, H.S.; Mather, T.N.

2006-01-01

The roles of entomologic risk factors, including density of nymphal blacklegged ticks (Ixodes scapularis), prevalence of nymphal infection with the etiologic agent (Borrelia burgdorferi), and density of infected nymphs, in determining the risk of human Lyme disease were assessed at residences in the endemic community of South Kingstown, RI. Nymphs were sampled between May and July from the wooded edge around 51 and 47 residential properties in 2002 and 2003, respectively. Nymphs were collected from all residences sampled. Tick densities, infection rates, and densities of infected nymphs were all significantly higher around homes reporting Lyme disease histories in 2003, while only infection rates were significantly higher in 2002. However, densities of infected nymphs did not significantly predict the probability of Lyme disease at a residence (by logistic regression) in either year. There were no significant differences in entomologic risk factors between homes with state-confirmed Lyme disease histories and homes with self-reported cases (not reported to the state health department). Therefore, although entomologic risk factors tended to be higher at residences with cases of Lyme disease, entomological indices, in the absence of human behavior measures, were not useful predictors of Lyme disease at the scale of individual residences in a tick-endemic community.

Psychological Assessment of Patients With Biotin-Thiamine-Responsive Basal Ganglia Disease.

Science.gov (United States)

Alfadhel, Majid; Al-Bluwi, Amal

2017-01-01

Biotin-thiamine-responsive basal ganglia disease is a devastating autosomal recessive inherited neurological disorder. We conducted a retrospective chart review of all patients with biotin-thiamine-responsive basal ganglia disease who underwent a formal psychological assessment. Six females and 3 males were included. Five patients (56%) had an average IQ, two patients (22%) had mild delay, and two (22%) had severe delay. A normal outcome was directly related to the time of diagnosis and initiation of treatment. Early diagnosis and immediate commencement of treatment were associated with a favorable outcome and vice versa. The most affected domain was visual motor integration, while understanding and mathematical problem-solving were the least affected. In summary, this is the first study discussing the psychological assessment of patients with biotin-thiamine-responsive basal ganglia disease. The results of this study alert clinicians to consider prompt initiation of biotin and thiamine in any patient presenting with neuroregression and a basal ganglia lesion on a brain magnetic resonance imaging.

Nasopharyngeal Carcinoma Treated with Precision-Oriented Radiation Therapy Techniques Including Intensity-Modulated Radiotherapy: Preliminary Results

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Wen-Shan Liu

2004-02-01

Full Text Available This paper reports preliminary results with intensity-modulated radiotherapy (IMRT in nasopharyngeal carcinoma (NPC. Between August 2000 and May 2001, we treated 19 patients with NPC using IMRT. Twelve patients had stage I-II disease and seven had stage III-IV disease. Six patients received 9.0-19.8 Gy three-dimensional conformal radiotherapy (3D-CRT before IMRT and 18 patients received a brachytherapy boost after IMRT. The mean follow-up time was 13.0 months. All patients with stage II-IV disease except one received two cycles of chemoradiotherapy with cisplatin and 5-fluorouracil (5-FU during radiotherapy, followed by two to four cycles of chemotherapy after radiotherapy. Tumor response was assessed using clinical examination and computerized tomography or magnetic resonance imaging. The mean doses administered to the gross tumor volume and clinical tumor volume were 70.9 Gy and 63.2 Gy, respectively. The mean doses administered to the right and left parotid glands were 38.1 Gy and 38.6 Gy, respectively. All 19 patients had a complete response of primary and lymph node disease. Grade III mucositis developed during chemoradiotherapy in 15 patients (79%. In addition, clinical grade I xerostomia was recorded in nine patients, grade II in nine, and grade III in one. This study demonstrated that 3D-CRT, IMRT, intracavitary brachytherapy, and chemotherapy are effective and safe methods to treat NPC. Although IMRT treatment spared parotid gland function, its efficacy may be significantly influenced by disease stage and location of the neck lymph nodes. More cases and a longer follow-up to assess survival and complications are planned.

Preliminary assessment of the risk linked to furan ingestion by babies consuming only ready-to-eat food.

Science.gov (United States)

Scholl, Georges; Humblet, Marie-France; Scippo, Marie-Louise; De Pauw, Edwin; Eppe, Gauthier; Saegerman, Claude

2013-01-01

The risk linked to furan ingestion has been assessed in previous papers for Belgian adults and children. The present paper focuses on infants consuming only ready-to-eat baby food. As there is no Belgian baby dietary database, the furan exposure assessment was carried out by using an Italian infant consumption database and Belgian contamination data. The estimated daily intake (EDI) was calculated according to a deterministic methodology. It involved 42 commercially available ready-to-eat baby food and 36 baby consumption records. The mean EDI was 1460 ng*(kg(bw)*day)⁻¹ which is 3.8 times higher than the 381 ng*(kg(bw)*day)⁻¹ reported for Belgian adults, and 3.5 times higher than the 419 ng*(kg(bw)*day)⁻¹ measured for Belgian children. To assess and characterise the risk for babies' exposure, the margin of exposure (MoE) was calculated. It highlighted that 74% of infants have a MoE < 1000, with a minimum of 140. However, these are only preliminary results as they were calculated from a very small dataset and the infant cytochrome P450 activity is significantly different compared with the adult's. Therefore, the risk linked to furan ingestion by babies should be assessed in a different manner. To this end, additional data regarding a baby diet as well as a better understanding of furan toxicity for babies are needed to characterise more accurately the risk for infants.

Physiologic assessment of coronary artery disease: Focus on fractional flow reserve

International Nuclear Information System (INIS)

Hwang, Do Yeon; Koo, Bon Kwon; Lee, Joo Myung

2016-01-01

The presence of myocardial ischemia is the most important prognostic factor in patients with ischemic heart disease. Fractional flow reserve (FFR) is a gold standard invasive method used to detect the stenosis-specific myocardial ischemia. FFR-guided revascularization strategy is superior to angiography-guided strategy. The recently developed hyperemia-free index, instantaneous wave free ratio is being actively investigated. A non-invasive FFR derived from coronary CT angiography is now used in clinical practice. Due to rapid expansion of invasive and non-invasive physiologic assessment, comprehensive understanding of the role and potential pitfalls of each modality are required for its application. In this review, we focus on the basic and clinical aspects of physiologic assessment in ischemic heart disease

Physiologic assessment of coronary artery disease: Focus on fractional flow reserve

Energy Technology Data Exchange (ETDEWEB)

Hwang, Do Yeon; Koo, Bon Kwon [Dept. of Radiology, Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul (Korea, Republic of); Lee, Joo Myung [Dept. of Internal Medicine and Cardiovascular Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

2016-06-15

The presence of myocardial ischemia is the most important prognostic factor in patients with ischemic heart disease. Fractional flow reserve (FFR) is a gold standard invasive method used to detect the stenosis-specific myocardial ischemia. FFR-guided revascularization strategy is superior to angiography-guided strategy. The recently developed hyperemia-free index, instantaneous wave free ratio is being actively investigated. A non-invasive FFR derived from coronary CT angiography is now used in clinical practice. Due to rapid expansion of invasive and non-invasive physiologic assessment, comprehensive understanding of the role and potential pitfalls of each modality are required for its application. In this review, we focus on the basic and clinical aspects of physiologic assessment in ischemic heart disease.

Clinical Applications of Natriuretic Peptides in Assessment of Valvular Heart Disease

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Abhishek Sharma

2015-01-01

Full Text Available Biomarkers such as natriuretic peptides (NPs have evolving clinical utility beyond the scope of heart failure. The role of NPs in the management of valvular heart disease is a growing area of investigation. NPs have much potential in the assessment of asymptomatic patients with hemodynamically significant valvular lesions who have traditionally been excluded from consideration of surgical intervention. NPs also have a role in the risk stratification of these patients as well as in routine surveillance and monitoring. Together with echocardiographic data and functional status, NPs are being incorporated into the management of valvular heart disease. In this review we examine the evidence for the role of natriuretic peptides in assessment of VHD.

Clinical Applications of Natriuretic Peptides in Assessment of Valvular Heart Disease

Science.gov (United States)

Ahmed, Vaseem; Garg, Aakash; Aggarwal, Chirag

2015-01-01

Biomarkers such as natriuretic peptides (NPs) have evolving clinical utility beyond the scope of heart failure. The role of NPs in the management of valvular heart disease is a growing area of investigation. NPs have much potential in the assessment of asymptomatic patients with hemodynamically significant valvular lesions who have traditionally been excluded from consideration of surgical intervention. NPs also have a role in the risk stratification of these patients as well as in routine surveillance and monitoring. Together with echocardiographic data and functional status, NPs are being incorporated into the management of valvular heart disease. In this review we examine the evidence for the role of natriuretic peptides in assessment of VHD. PMID:26265794

Deep repository for long-lived low- and intermediate-level waste. Preliminary safety assessment

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-11-01

A preliminary safety assessment has been performed of a deep repository for long-lived low- and intermediate-level waste, SFL 3-5. The purpose of the study is to investigate the capacity of the facility to act as a barrier to the release of radionuclides and toxic pollutants, and to shed light on the importance of the location of the repository site. A safety assessment (SR 97) of a deep repository for spent fuel has been carried out at the same time. In SR 97, three hypothetical repository sites have been selected for study. These sites exhibit fairly different conditions in terms of hydrogeology, hydrochemistry and ecosystems. To make use of information and data from the SR 97 study, we have assumed that SFL 3-5 is co-sited with the deep repository for spent fuel. A conceivable alternative is to site SFL 3-5 as a completely separate repository. The focus of the SFL 3-5 study is a quantitative analysis of the environmental impact for a reference scenario, while other scenarios are discussed and analyzed in more general terms. Migration in the repository's near- and far-field has been taken into account in the reference scenario. Environmental impact on the three sites has also been calculated. The calculations are based on an updated forecast of the waste to be disposed of in SFL 3-5. The forecast includes radionuclide content, toxic metals and other substances that have a bearing on a safety assessment. The safety assessment shows how important the site is for safety. Two factors stand out as being particularly important: the water flow at the depth in the rock where the repository is built, and the ecosystem in the areas on the ground surface where releases may take place in the future. Another conclusion is that radionuclides that are highly mobile and long-lived, such as {sup 36}Cl and {sup 93}Mo , are important to take into consideration. Their being long-lived means that barriers and the ecosystems must be regarded with a very long time horizon.

111In autologous leucocytes in the diagnosis and assessment of inflammatory bowel disease

International Nuclear Information System (INIS)

Saverymuttu, S.H.; Peters, A.M.; Reavy, H.J.; Danpure, H.J.; Osman, S.; Chadwick, V.S.; Hodgson, H.J.; Lavender, J.P.

1982-01-01

111 In-labelled leucocytes were used to obtain gamma camera images of inflamed of bowel in a wide variety of inflammatory bowel disease. No false positive scans were observed in the irritable bowel syndrome and in bowel malignancy. All patients with moderate or severely active disease had positive scans. Faecal excretion of 111 Indium increased with disease severity. 111 In-tropolone labelling appeared to offer the advantage over 111 In-acac labelling in localising inflamed bowel earlier. In many cases the bowel was imaged within 40 min of re-injection of the leucocytes. 111 In-leucocyte scanning provides a novel approach to the problem of diagnosis and assessment of inflammatory bowel disease. It is non-invasive, requires no bowel preparation and thus is safe in the acutely sick patient where conventional radiological imaging methods may be hazardous. 111 Indium faecal excretion provides an objective assessment of disease activity which should prove useful in evaluating treatment regimes

Correlation of Gastroesophageal reflux disease Assessment Symptom Questionnaire to impedance-pH measurements in children.

Science.gov (United States)

Prachuapthunyachart, Sittichoke; Jarasvaraparn, Chaowapong; Gremse, David A

2017-01-01

Esophageal multichannel intraluminal impedance-pH monitoring has become one of the preferred tests to correlate observed reflux-like behaviors with esophageal reflux events. The Gastroesophageal reflux disease Assessment Symptom Questionnaire is a validated tool used to distinguish infants with gastroesophageal reflux disease from healthy children. The aim of this study was to determine whether the Gastroesophageal reflux disease Assessment Symptom Questionnaire composite symptom scores and individual symptom scores correlate with outcomes in esophageal multichannel intraluminal impedance-pH monitoring. A total of 26 patients with gastroesophageal reflux disease-associated symptoms, aged 0-2 years, for whom both esophageal multichannel intraluminal impedance-pH monitoring and Gastroesophageal reflux disease Assessment Symptom Questionnaire survey results were available were included in the study. Gastroesophageal reflux disease Assessment Symptom Questionnaire score data were collected from a 7-day recall of parent's responses about the frequency and severity of gastroesophageal reflux disease symptoms, which determined the individual symptom scores. The composite symptom scores is the sum of all individual symptom scores. Multichannel intraluminal impedance-pH study results were compared to Gastroesophageal reflux disease Assessment Symptom Questionnaire data using Pearson correlation. Among 26 patients, a total number of 2817 (1700 acid and 1117 non-acid) reflux episodes and 845 clinical reflux behaviors were recorded. There were significant correlations between the reflux index and the individual symptom scores for coughing/gagging/choking (r 2 = 0.2842, p = 0.005), the impedance score and individual symptom scores for coughing/gagging/choking (r 2 = 0.2482, p = 0.009), the reflux symptom index for acid reflux-related coughing/gagging/choking and the individual symptom scores for coughing/gagging/choking (r 2 = 0.1900, p = 0.026), the impedance score and

Automatic and Objective Assessment of Alternating Tapping Performance in Parkinson’s Disease

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Mevludin Memedi

2013-12-01

Full Text Available This paper presents the development and evaluation of a method for enabling quantitative and automatic scoring of alternating tapping performance of patients with Parkinson’s disease (PD. Ten healthy elderly subjects and 95 patients in different clinical stages of PD have utilized a touch-pad handheld computer to perform alternate tapping tests in their home environments. First, a neurologist used a web-based system to visually assess impairments in four tapping dimensions (‘speed’, ‘accuracy’, ‘fatigue’ and ‘arrhythmia’ and a global tapping severity (GTS. Second, tapping signals were processed with time series analysis and statistical methods to derive 24 quantitative parameters. Third, principal component analysis was used to reduce the dimensions of these parameters and to obtain scores for the four dimensions. Finally, a logistic regression classifier was trained using a 10-fold stratified cross-validation to map the reduced parameters to the corresponding visually assessed GTS scores. Results showed that the computed scores correlated well to visually assessed scores and were significantly different across Unified Parkinson’s Disease Rating Scale scores of upper limb motor performance. In addition, they had good internal consistency, had good ability to discriminate between healthy elderly and patients in different disease stages, had good sensitivity to treatment interventions and could reflect the natural disease progression over time. In conclusion, the automatic method can be useful to objectively assess the tapping performance of PD patients and can be included in telemedicine tools for remote monitoring of tapping.

Assessment of Social Information Processing in early childhood: development and initial validation of the Schultz Test of Emotion Processing-Preliminary Version.

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Schultz, David; Ambike, Archana; Logie, Sean Kevin; Bohner, Katherine E; Stapleton, Laura M; Vanderwalde, Holly; Min, Christopher B; Betkowski, Jennifer A

2010-07-01

Crick and Dodge's (Psychological Bulletin 115:74-101, 1994) social information processing model has proven very useful in guiding research focused on aggressive and peer-rejected children's social-cognitive functioning. Its application to early childhood, however, has been much more limited. The present study responds to this gap by developing and validating a video-based assessment tool appropriate for early childhood, the Schultz Test of Emotion Processing-Preliminary Version (STEP-P). One hundred twenty-five Head Start preschool children participated in the study. More socially competent children more frequently attributed sadness to the victims of provocation and labeled aggressive behaviors as both morally unacceptable and less likely to lead to positive outcomes. More socially competent girls labeled others' emotions more accurately. More disruptive children more frequently produced physically aggressive solutions to social provocations, and more disruptive boys less frequently interpreted social provocations as accidental. The STEP-P holds promise as an assessment tool that assesses knowledge structures related to the SIP model in early childhood.

Strengthening Chronic Disease Prevention Programming: the Toward Evidence-Informed Practice (TEIP) Program Assessment Tool

Science.gov (United States)

Albert, Dayna; Fortin, Rebecca; Lessio, Anne; Herrera, Christine; Hanning, Rhona; Rush, Brian

2013-01-01

Best practices identified solely on the strength of research evidence may not be entirely relevant or practical for use in community-based public health and the practice of chronic disease prevention. Aiming to bridge the gap between best practices literature and local knowledge and expertise, the Ontario Public Health Association, through the Toward Evidence-Informed Practice initiative, developed a set of resources to strengthen evidence-informed decision making in chronic disease prevention programs. A Program Assessment Tool, described in this article, emphasizes better processes by incorporating review criteria into the program planning and implementation process. In a companion paper, “Strengthening Chronic Disease Prevention Programming: The Toward Evidence-Informed Practice (TEIP) Program Evidence Tool,” we describe another tool, which emphasizes better evidence by providing guidelines and worksheets to identify, synthesize, and incorporate evidence from a range of sources (eg, peer-reviewed literature, gray literature, local expertise) to strengthen local programs. The Program Assessment Tool uses 19 criteria derived from literature on best and promising practices to assess and strengthen program planning and implementation. We describe the benefits, strengths, and challenges in implementing the tool in 22 community-based chronic disease prevention projects in Ontario, Canada. The Program Assessment Tool helps put best processes into operation to complement adoption and adaptation of evidence-informed practices for chronic disease prevention. PMID:23721789

PoCos: Population Covering Locus Sets for Risk Assessment in Complex Diseases.

Directory of Open Access Journals (Sweden)

Marzieh Ayati

2016-11-01

Full Text Available Susceptibility loci identified by GWAS generally account for a limited fraction of heritability. Predictive models based on identified loci also have modest success in risk assessment and therefore are of limited practical use. Many methods have been developed to overcome these limitations by incorporating prior biological knowledge. However, most of the information utilized by these methods is at the level of genes, limiting analyses to variants that are in or proximate to coding regions. We propose a new method that integrates protein protein interaction (PPI as well as expression quantitative trait loci (eQTL data to identify sets of functionally related loci that are collectively associated with a trait of interest. We call such sets of loci "population covering locus sets" (PoCos. The contributions of the proposed approach are three-fold: 1 We consider all possible genotype models for each locus, thereby enabling identification of combinatorial relationships between multiple loci. 2 We develop a framework for the integration of PPI and eQTL into a heterogenous network model, enabling efficient identification of functionally related variants that are associated with the disease. 3 We develop a novel method to integrate the genotypes of multiple loci in a PoCo into a representative genotype to be used in risk assessment. We test the proposed framework in the context of risk assessment for seven complex diseases, type 1 diabetes (T1D, type 2 diabetes (T2D, psoriasis (PS, bipolar disorder (BD, coronary artery disease (CAD, hypertension (HT, and multiple sclerosis (MS. Our results show that the proposed method significantly outperforms individual variant based risk assessment models as well as the state-of-the-art polygenic score. We also show that incorporation of eQTL data improves the performance of identified POCOs in risk assessment. We also assess the biological relevance of PoCos for three diseases that have similar biological mechanisms

Association between alcohol consumption and periodontal disease among older Nigerians in plateau state: a preliminary study.

Science.gov (United States)

Akpata, E Samuel; Adeniyi, Abiola A; Enwonwu, Cyril O; Adeleke, Oyeladun A; Otoh, Emmanuel C

2016-09-01

To report the periodontal status of older adults in Plateau State, Nigeria, and determine its Association with alcohol consumption. Periodontal disease is common among Nigerians, and the prevalence increases with age. The role that alcohol consumption plays in the occurrence of the disease among Africans is uncertain. Sample selection was performed using a multistage cluster sampling technique among older adults in Plateau State, Nigeria. Interviews, using structured questionnaires, were conducted for each of the participants. Clinical examinations were then carried out to determine the occurrence of periodontal disease, assessed by clinical attachment loss and probing depth. The prevalence of periodontal disease was 79%, being severe in 46% of the population. Almost half of the participants (46.7%) examined were still actively consuming alcohol, among which 48% reported a history of intoxication. There was no statistically significant relationship between periodontal disease and the frequency of alcohol consumption, or quantity consumed on each occasion. However, alcohol consumption was highly correlated with periodontal disease among those who reported intoxication from the drink (r = 0.095; p = 0.033). A history of intoxication with alcohol was the only significant predictor of periodontal disease, after adjusting for age and gender. Periodontal disease was highly prevalent among older Nigerians in this study. Apart from those who reported intoxication from alcohol, there was no statistically significant relationship between the prevalence of periodontal disease and the frequency of alcohol consumption or the quantity consumed on each occasion. © 2014 John Wiley & Sons A/S and The Gerodontology Association. Published by John Wiley & Sons Ltd.

Comprehensive development plans for the low- and intermediate-level radioactive waste disposal facility in Korea and preliminary safety assessment

Energy Technology Data Exchange (ETDEWEB)

Jung, Kang Il; Kim, Jin Hyeong; Kwon, Mi Jin; Jeong, Mi Seon; Hong, Sung Wook; Park, Jin Beak [Korea Radioactive Waste Agency, Daejeon (Korea, Republic of)

2016-12-15

The disposal facility in Gyeongju is planning to dispose of 800,000 packages of low- and intermediate- level radioactive waste. This facility will be developed as a complex disposal facility that has various types of disposal facilities and accompanying management. In this study, based on the comprehensive development plan of the disposal facility, a preliminary post-closure safety assessment is performed to predict the phase development of the total capacity for the 800,000 packages to be disposed of at the site. The results for each scenario meet the performance target of the disposal facility. The assessment revealed that there is a significant impact of the inventory of intermediate-level radionuclide waste on the safety evaluation. Due to this finding, we introduce a disposal limit value for intermediate-level radioactive waste. With stepwise development of safety case, this development plan will increase the safety of disposal facilities by reducing uncertainties within the future development of the underground silo disposal facilities.

The accuracy of self-reported medical history: a preliminary analysis of the promise of internet-based research in Inflammatory Bowel Diseases.

Science.gov (United States)

Kelstrup, Anne Mette; Juillerat, Pascal; Korzenik, Joshua

2014-05-01

Internet-based surveys provide a potentially important tool for Inflammatory Bowel Disease (IBD) research. The advantages include low cost, large numbers of participants, rapid study completion and less extensive infrastructure than traditional methods. The aim was to determine the accuracy of patient self-reporting in internet-based IBD research and identify predictors of greater reliability. 197 patients from a tertiary care center answered an online survey concerning personal medical history and an evaluation of disease specific knowledge. Self-reported medical details were compared with data abstracted from medical records. Agreement was assessed by kappa (κ) statistics. Participants responded correctly with excellent agreement (κ=0.96-0.97) on subtype of IBD and history of surgery. The agreement was also excellent for colectomy (κ=0.88) and small bowel resection (κ=0.91), moderate for abscesses and fistulas (κ=0.60 and 0.63), but poor regarding partial colectomy (κ=0.39). Time since last colonoscopy was self-reported with better agreement (κ=0.84) than disease activity. For disease location/extent, moderate agreements at κ=69% and 64% were observed for patients with Crohn's disease and ulcerative colitis, respectively. Subjects who scored higher than the average in the IBD knowledge assessment were significantly more accurate about disease location than their complementary group (74% vs. 59%, p=0.02). This study demonstrates that IBD patients accurately report their medical history regarding type of disease and surgical procedures. More detailed medical information is less reliably reported. Disease knowledge assessment may help in identifying the most accurate individuals and could therefore serve as validity criteria. Internet-based surveys are feasible with high reliability about basic disease features only. However, the participants in this study were engaged at a tertiary center, which potentially leads to a bias and compromises generalization to

Introducing a multifaceted exercise intervention particular to older adults diagnosed with Parkinson's disease: a preliminary study.

Science.gov (United States)

Peacock, Corey A; Sanders, Gabriel J; Wilson, Kayla A; Fickes-Ryan, Emily J; Corbett, Duane B; von Carlowitz, Kyle-Patrick A; Ridgel, Angela L

2014-08-01

With a substantial increase in diagnosed Parkinson's disease, it is of great importance to examine tolerance and physical measures of evolving exercise interventions. Of particular importance, a multifaceted exercise intervention combining active-assisted cycling and resistance training to older adults diagnosed with Parkinson's disease is being assessed. Fourteen older adults diagnosed with Parkinson's disease and ten healthy older adults (67.5 ± 7.9 years of age) engaged in an 8-week, 24-session, multifaceted exercise protocol. The protocol consisted of both active-assisted cycling and resistance training. Tolerance was measured, as well as multiple indicators of health-related physical fitness. These indicators examined improvements in cardiovascular performance, muscular strength, muscular endurance, and flexibility. Twenty-two older adults and older adults diagnosed with Parkinson's disease tolerated the intervention by completing all 24 sessions. Repeated-measures analysis of variance demonstrated significant (P ≤ 0.003) improvements in cardiovascular performance, muscular strength, muscular endurance, and flexibility for both groups of individuals. The multifaceted intervention is the first to combine both active-assisted cycling and resistance training. The older adult and the older adult diagnosed with Parkinson's disease exhibited both tolerance and health-related improvements in physical fitness following the intervention.

New method of scoliosis assessment: preliminary results using computerized photogrammetry.

Science.gov (United States)

Aroeira, Rozilene Maria Cota; Leal, Jefferson Soares; de Melo Pertence, Antônio Eustáquio

2011-09-01

A new method for nonradiographic evaluation of scoliosis was independently compared with the Cobb radiographic method, for the quantification of scoliotic curvature. To develop a protocol for computerized photogrammetry, as a nonradiographic method, for the quantification of scoliosis, and to mathematically relate this proposed method with the Cobb radiographic method. Repeated exposure to radiation of children can be harmful to their health. Nevertheless, no nonradiographic method until now proposed has gained popularity as a routine method for evaluation, mainly due to a low correspondence to the Cobb radiographic method. Patients undergoing standing posteroanterior full-length spine radiographs, who were willing to participate in this study, were submitted to dorsal digital photography in the orthostatic position with special surface markers over the spinous process, specifically the vertebrae C7 to L5. The radiographic and photographic images were sent separately for independent analysis to two examiners, trained in quantification of scoliosis for the types of images received. The scoliosis curvature angles obtained through computerized photogrammetry (the new method) were compared to those obtained through the Cobb radiographic method. Sixteen individuals were evaluated (14 female and 2 male). All presented idiopathic scoliosis, and were between 21.4 ± 6.1 years of age; 52.9 ± 5.8 kg in weight; 1.63 ± 0.05 m in height, with a body mass index of 19.8 ± 0.2. There was no statistically significant difference between the scoliosis angle measurements obtained in the comparative analysis of both methods, and a mathematical relationship was formulated between both methods. The preliminary results presented demonstrate equivalence between the two methods. More studies are needed to firmly assess the potential of this new method as a coadjuvant tool in the routine following of scoliosis treatment.

Hyperpolarized 3He magnetic resonance imaging: Preliminary evaluation of phenotyping potential in chronic obstructive pulmonary disease

International Nuclear Information System (INIS)

Mathew, Lindsay; Kirby, Miranda; Etemad-Rezai, Roya; Wheatley, Andrew; McCormack, David G.; Parraga, Grace

2011-01-01

Rationale and objectives: Emphysema and small airway obstruction are the pathological hallmarks of chronic obstructive pulmonary disease (COPD). The aim of this pilot study in a small group of chronic obstructive pulmonary disease (COPD) patients was to quantify hyperpolarized helium-3 ( 3 He) magnetic resonance imaging (MRI) functional and structural measurements and to explore the potential role for 3 He MRI in detecting the lung structural and functional COPD phenotypes. Materials and methods: We evaluated 20 ex-smokers with stage I (n = 1), stage II (n = 9) and stage III COPD (n = 10). All subjects underwent same-day plethysmography, spirometry, 1 H MRI and hyperpolarized 3 He MRI at 3.0 T. 3 He ventilation defect percent (VDP) was generated from 3 He static ventilation images and 1 H thoracic images and the 3 He apparent diffusion coefficient (ADC) was derived from diffusion-weighted MRI. Results: Based on the relative contribution of normalized ADC and VDP, there was evidence of a predominant 3 He MRI measurement in seven patients (n = 3 mainly ventilation defects or VDP dominant (VD), n = 4 mainly increased ADC or ADC dominant (AD)). Analysis of variance (ANOVA) showed significantly lower ADC for subjects with predominantly elevated VDP (p = 0.02 compared to subjects with predominantly elevated ADC; p = 0.008 compared to mixed group) and significantly decreased VDP for subjects with predominantly elevated ADC (p = 0.003, compared to mixed group). Conclusion: In this small pilot study, a preliminary analysis shows the potential for 3 He MRI to categorize or phenotype COPD ex-smokers, providing good evidence of feasibility for larger prospective studies.

CRED REA Coral Health and Disease Assessment at Guam, Marianas Archipelago in 2007

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Coral health and disease assessments were conducted along 2 consecutively placed 25-m transects, as part of Rapid Ecological Assessments conducted at 10 sites at...

Prognostic factors in pulmonary arterial hypertension: assessing the course of the disease

Directory of Open Access Journals (Sweden)

L.S. Howard

2011-12-01

Full Text Available The practical management of pulmonary arterial hypertension (PAH requires an accurate assessment of disease severity and prognosis. A number of prognostic indicators are known to be associated with patient outcome, and recent treatment guidelines advocate using such parameters to guide management decisions. Although PAH is characterised by the presence of pulmonary vasculopathy, it is the response of the right ventricle to an increased afterload that is the greatest determinant of a patient's symptoms and survival; thus, measurements that capture right ventricular function provide the best potential to assess PAH severity. One challenge is to understand how the tests we use in everyday clinical practice relate to right heart function in PAH patients, and how current measures can be improved and developed to optimise assessment of disease status and progress. Future research in the field of PAH should focus on how best to assess right heart function, and which measures or combination of measures provide the most relevant information for the individual patient.

78 FR 8522 - Chlorpyrifos Registration Review; Preliminary Evaluation of the Potential Risk From...

Science.gov (United States)

2013-02-06

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2008-0850; FRL-9376-5] Chlorpyrifos Registration... preliminary volatilization assessment for the registration review of chlorpyrifos and opens a public comment... assessment for chlorpyrifos uses. After reviewing comments received during the public comment period, EPA...

Longitudinal diffusion MRI for treatment response assessment: Preliminary experience using an MRI-guided tri-cobalt 60 radiotherapy system.

Science.gov (United States)

Yang, Yingli; Cao, Minsong; Sheng, Ke; Gao, Yu; Chen, Allen; Kamrava, Mitch; Lee, Percy; Agazaryan, Nzhde; Lamb, James; Thomas, David; Low, Daniel; Hu, Peng

2016-03-01

To demonstrate the preliminary feasibility of a longitudinal diffusion magnetic resonance imaging (MRI) strategy for assessing patient response to radiotherapy at 0.35 T using an MRI-guided radiotherapy system (ViewRay). Six patients (three head and neck cancer, three sarcoma) who underwent fractionated radiotherapy were enrolled in this study. A 2D multislice spin echo single-shot echo planar imaging diffusion pulse sequence was implemented on the ViewRay system and tested in phantom studies. The same pulse sequence was used to acquire longitudinal diffusion data (every 2-5 fractions) on the six patients throughout the entire course of radiotherapy. The reproducibility of the apparent diffusion coefficient (ADC) measurements was assessed using reference regions and the temporal variations of the tumor ADC values were evaluated. In diffusion phantom studies, the ADC values measured on the ViewRay system matched well with reference ADC values with ViewRay MRI. Larger patient cohort studies are warranted to correlate the longitudinal diffusion measurements to patient outcomes. Such an approach may enable response-guided adaptive radiotherapy.

A Critical Assessment of Research on Neurotransmitters in Alzheimer’s Disease

Science.gov (United States)

Reddy, P. Hemachandra

2018-01-01

The purpose of this mini-forum, “Neurotransmitters and Alzheimer’s Disease”, is to critically assess the current status of neurotransmitters in Alzheimer’s disease. Neurotransmitters are essential neurochemicals that maintain synaptic and cognitive functions in mammals, including humans, by sending signals across pre- to post-synaptic neurons. Authorities in the fields of synapses and neurotransmitters of Alzheimer’s disease summarize the current status of basic biology of synapses and neurotransmitters, and also update the current status of clinical trials of neurotransmitters in Alzheimer’s disease. This article discusses the prevalence, economic impact, and stages of Alzheimer’s dementia in humans. PMID:28409748

New Reactor Siting in Finland, Hanhikivi Site in Pyhaejoki - STUK preliminary safety assessment

International Nuclear Information System (INIS)

Nevalainen, Janne

2013-01-01

STUK has performed a preliminary assessment of the Decision-in-Principle on the Fennovoima application. A variety of factors must be considered in the selection of a site, including effects of the site on the plant design and the effects of the plant on the site environment. These include external hazards, both natural and human-induced. Since this is a new site, an extensive siting process is followed, that can include an EIA. A site survey is performed to identify candidate sites, after investigating a large region and rejecting unsuitable sites. The remaining sites are then screened and compared on the basis of safety and other considerations to select one or more preferred sites. Natural hazards include geology, seismology, hydrology and meteorology. Offshore ice will be a particular hazard for this plant, since the site is on average only 1.5 m above sea level. The design basis earthquake corresponds to a return frequency of 100,000 years, with 50 % confidence. The existing sites in southern Finland used a design peak ground acceleration of 0.1 g with the ground response spectrum maximum at 10 Hz. The candidate sites in northern Finland will require a peak ground acceleration of 0.2 g with the ground response spectrum maximum at 25 Hz

Initial development and preliminary validation of a new negative symptom measure: the Clinical Assessment Interview for Negative Symptoms (CAINS).

Science.gov (United States)

Forbes, Courtney; Blanchard, Jack J; Bennett, Melanie; Horan, William P; Kring, Ann; Gur, Raquel

2010-12-01

As part of an ongoing scale development process, this study provides an initial examination of the psychometric properties and validity of a new interview-based negative symptom instrument, the Clinical Assessment Interview for Negative Symptoms (CAINS), in outpatients with schizophrenia or schizoaffective disorder (N = 37). The scale was designed to address limitations of existing measures and to comprehensively assess five consensus-based negative symptoms: asociality, avolition, anhedonia (consummatory and anticipatory), affective flattening, and alogia. Results indicated satisfactory internal consistency reliability for the total CAINS scale score and promising inter-rater agreement, with clear areas identified in need of improvement. Convergent validity was evident in general agreement between the CAINS and alternative negative symptom measures. Further, CAINS subscales significantly correlated with relevant self-report emotional experience measures as well as with social functioning. Discriminant validity of the CAINS was strongly supported by its small, non-significant relations with positive symptoms, general psychiatric symptoms, and depression. These preliminary data on an early beta-version of the CAINS provide initial support for this new assessment approach to negative symptoms and suggest directions for further scale development. Copyright © 2010 Elsevier B.V. All rights reserved.

Parent knowledge of disease management in cystic fibrosis: Assessing behavioral treatment management.

Science.gov (United States)

Nicolais, Christina J; Bernstein, Ruth; Riekert, Kristin A; Quittner, Alexandra L

2018-02-01

Cystic fibrosis (CF) is a life-shortening, burdensome disease requiring complex knowledge to manage the disease. Significant gaps in knowledge have been documented for parents, which may lead to unintentionally poor adherence and insufficient transfer of treatment responsibility from parents to adolescents. There are no current, validated measures of parent knowledge for this population and there are no measures that assess the knowledge required for day-to-day behavioral management of CF. We assessed the psychometric properties of the parent version of the Knowledge of Disease Management-Cystic Fibrosis measure (KDM-CF-P) using data from iCARE (I Change Adherence and Raise Expectations), a randomized control adherence intervention trial. A total of 196 parents in the iCARE standard care/control arm completed 35 items assessing their knowledge of disease management at their 12-month study visit, prior to beginning the intervention. Items were eliminated from the measure if they met the threshold for ceiling effects, were deemed clinically irrelevant, or did not correlate well with their intended scale. Item-to-total correlations, confirmatory factor analysis, discriminant function, reliability, and convergent validity were calculated. The KDM-CF-P (19 items) demonstrated internal consistency of KR20 = 0.60 on each scale and a two-scale structure. Convergent validity for knowledge scores was found with maternal education, family income, and type of medical insurance. Parents correctly answered approximately 85% of items on the KDM-CF-P. The KDM-CF-P psychometrics support a two-scale measure with clinical utility. It is useful for assessing gaps in knowledge that can be remediated through individualized, tailored interventions. © 2017 Wiley Periodicals, Inc.

Assessment of jeopardized myocardium in patients with one-vessel disease

International Nuclear Information System (INIS)

Iskandrian, A.S.; Lichtenberg, R.; Segal, B.L.; Mintz, G.S.; Mundth, E.D.; Hakki, A.-H.; Kimbiris, D.; Bemis, C.E.; Croll, M.N.; Kane, S.A.

1982-01-01

The size of the perfusion defect was assessed from a quantitative analysis of exercise thallium-201 images. Quantitative analysis was determined by measuring the area and the perimeter of the perfusion defect and expressing it as a percentage of the total left ventricular area or perimeter in three projections. Using this technique, we studied 50 patients with one-vessel disease of 50% or greater diameter narrowing. The planimetric and the perimetric methods correlated well (p<0.001, r=0.97). Of the 11 patients with less than 70% diameter narrowing, only one patient had abnormal exercise thallium-201 images. Of the remaining 39 patients with 70% or greater diameter narrowing, 35 had abnormal exercise images. The defects were larger in patients with left anterior descending coronary artery disease (33 +/- 10%; mean +/- SD by perimetry) than in patients with left circumflex coronary artery disease (19 +/- 14%, p<0.01) or right coronary artery disease (17 +/- 11%, p<0.01). There was also significant variation in the sizes of the defects in the three projections in patients with left circumflex and right coronary artery disease, but not in patients with left anterior descending coronary artery disease. Patients with left anterior descending coronary artery disease with collaterals had smaller defects than their counterparts without collaterals

Alzheimer's Disease Assessment: A Review and Illustrations Focusing on Item Response Theory Techniques.

Science.gov (United States)

Balsis, Steve; Choudhury, Tabina K; Geraci, Lisa; Benge, Jared F; Patrick, Christopher J

2018-04-01

Alzheimer's disease (AD) affects neurological, cognitive, and behavioral processes. Thus, to accurately assess this disease, researchers and clinicians need to combine and incorporate data across these domains. This presents not only distinct methodological and statistical challenges but also unique opportunities for the development and advancement of psychometric techniques. In this article, we describe relatively recent research using item response theory (IRT) that has been used to make progress in assessing the disease across its various symptomatic and pathological manifestations. We focus on applications of IRT to improve scoring, test development (including cross-validation and adaptation), and linking and calibration. We conclude by describing potential future multidimensional applications of IRT techniques that may improve the precision with which AD is measured.

Assessment of CF lung disease using motion corrected PROPELLER MRI: a comparison with CT

Energy Technology Data Exchange (ETDEWEB)

Ciet, Pierluigi [General Hospital Ca' Foncello, Radiology Department, Treviso (Italy); Sophia Children' s Hospital, Pediatric Pulmonology Erasmus MC, Rotterdam (Netherlands); Erasmus MC, Radiology, Rotterdam (Netherlands); Serra, Goffredo; Catalano, Carlo [University of Rome ' ' Sapienza' ' , Radiology, Rome (Italy); Bertolo, Silvia; Morana, Giovanni [General Hospital Ca' Foncello, Radiology Department, Treviso (Italy); Spronk, Sandra [Erasmus MC, Radiology, Rotterdam (Netherlands); Erasmus MC, Epidemiology, Rotterdam (Netherlands); Ros, Mirco [Ca' Foncello Hospital, Pediatrics, Treviso (Italy); Fraioli, Francesco [University College London (UCL), Institute of Nuclear Medicine, London (United Kingdom); Quattrucci, Serena [University of Rome Sapienza, Pediatrics, Rome (Italy); Assael, M.B. [Azienda Ospedaliera di Verona, Verona CF Center, Verona (Italy); Pomerri, Fabio [University of Padova, Department of Medicine-DIMED, Padova (Italy); Tiddens, Harm A.W.M. [Sophia Children' s Hospital, Pediatric Pulmonology Erasmus MC, Rotterdam (Netherlands); Erasmus MC, Radiology, Rotterdam (Netherlands)

2016-03-15

To date, PROPELLER MRI, a breathing-motion-insensitive technique, has not been assessed for cystic fibrosis (CF) lung disease. We compared this technique to CT for assessing CF lung disease in children and adults. Thirty-eight stable CF patients (median 21 years, range 6-51 years, 22 female) underwent MRI and CT on the same day. Study protocol included respiratory-triggered PROPELLER MRI and volumetric CT end-inspiratory and -expiratory acquisitions. Two observers scored the images using the CF-MRI and CF-CT systems. Scores were compared with intra-class correlation coefficient (ICC) and Bland-Altman plots. The sensitivity and specificity of MRI versus CT were calculated. MRI sensitivity for detecting severe CF bronchiectasis was 0.33 (CI 0.09-0.57), while specificity was 100 % (CI 0.88-1). ICCs for bronchiectasis and trapped air were as follows: MRI-bronchiectasis (0.79); CT-bronchiectasis (0.85); MRI-trapped air (0.51); CT-trapped air (0.87). Bland-Altman plots showed an MRI tendency to overestimate the severity of bronchiectasis in mild CF disease and underestimate bronchiectasis in severe disease. Motion correction in PROPELLER MRI does not improve assessment of CF lung disease compared to CT. However, the good inter- and intra-observer agreement and the high specificity suggest that MRI might play a role in the short-term follow-up of CF lung disease (i.e. pulmonary exacerbations). (orig.)

Assessment of CF lung disease using motion corrected PROPELLER MRI: a comparison with CT

International Nuclear Information System (INIS)

Ciet, Pierluigi; Serra, Goffredo; Catalano, Carlo; Bertolo, Silvia; Morana, Giovanni; Spronk, Sandra; Ros, Mirco; Fraioli, Francesco; Quattrucci, Serena; Assael, M.B.; Pomerri, Fabio; Tiddens, Harm A.W.M.

2016-01-01

To date, PROPELLER MRI, a breathing-motion-insensitive technique, has not been assessed for cystic fibrosis (CF) lung disease. We compared this technique to CT for assessing CF lung disease in children and adults. Thirty-eight stable CF patients (median 21 years, range 6-51 years, 22 female) underwent MRI and CT on the same day. Study protocol included respiratory-triggered PROPELLER MRI and volumetric CT end-inspiratory and -expiratory acquisitions. Two observers scored the images using the CF-MRI and CF-CT systems. Scores were compared with intra-class correlation coefficient (ICC) and Bland-Altman plots. The sensitivity and specificity of MRI versus CT were calculated. MRI sensitivity for detecting severe CF bronchiectasis was 0.33 (CI 0.09-0.57), while specificity was 100 % (CI 0.88-1). ICCs for bronchiectasis and trapped air were as follows: MRI-bronchiectasis (0.79); CT-bronchiectasis (0.85); MRI-trapped air (0.51); CT-trapped air (0.87). Bland-Altman plots showed an MRI tendency to overestimate the severity of bronchiectasis in mild CF disease and underestimate bronchiectasis in severe disease. Motion correction in PROPELLER MRI does not improve assessment of CF lung disease compared to CT. However, the good inter- and intra-observer agreement and the high specificity suggest that MRI might play a role in the short-term follow-up of CF lung disease (i.e. pulmonary exacerbations). (orig.)

Welfare effects of a disease eradication programme for dairy goats.

Science.gov (United States)

Muri, K; Leine, N; Valle, P S

2016-02-01

The Norwegian dairy goat industry has largely succeeded in controlling caprine arthritis encephalitis (CAE), caseous lymphadenitis (CLA) and paratuberculosis through a voluntary disease eradication programme called Healthier Goats (HG). The aim of this study was to apply an on-farm welfare assessment protocol to assess the effects of HG on goat welfare. A total of 30 dairy goat farms were visited, of which 15 had completed disease eradication and 15 had not yet started. Three trained observers assessed the welfare on 10 farms each. The welfare assessment protocol comprised both resource-based and animal-based welfare measures, including a preliminary version of qualitative behavioural assessments with five prefixed terms. A total of 20 goats in each herd were randomly selected for observations of human-animal interactions and physical health. The latter included registering abnormalities of eyes, nostrils, ears, skin, lymph nodes, joints, udder, claws and body condition score. For individual-level data, robust clustered logistic regression analyses with farm as cluster variable were conducted to assess the association with disease eradication. Wilcoxon rank-sum tests were used for comparisons of herd-level data between the two groups. Goats with swollen joints (indicative of CAE) and enlarged lymph nodes (indicative of CLA) were registered on 53% and 93% of the non-HG farms, respectively, but on none of the HG farms. The only other health variables with significantly lower levels in HG herds were skin lesions (P=0.008) and damaged ears due to torn out ear tags (PGoats on HG farms showed less fear of unknown humans (P=0.013), and the qualitative behavioural assessments indicated that the animals in these herds were calmer than in non-HG herds. Significantly more space and lower gas concentrations reflected the upgrading of buildings usually done on HG farms. In conclusion, HG has resulted in some welfare improvements beyond the elimination of infectious diseases

Technologies Assessing Limb Bradykinesia in Parkinson’s Disease

Science.gov (United States)

Hasan, Hasan; Athauda, Dilan S.; Foltynie, Thomas; Noyce, Alastair J.

2017-01-01

Background: The MDS-UPDRS (Movement Disorders Society – Unified Parkinson’s Disease Rating Scale) is the most widely used scale for rating impairment in PD. Subscores measuring bradykinesia have low reliability that can be subject to rater variability. Novel technological tools can be used to overcome such issues. Objective: To systematically explore and describe the available technologies for measuring limb bradykinesia in PD that were published between 2006 and 2016. Methods: A systematic literature search using PubMed (MEDLINE), IEEE Xplore, Web of Science, Scopus and Engineering Village (Compendex and Inspec) databases was performed to identify relevant technologies published until 18 October 2016. Results: 47 technologies assessing bradykinesia in PD were identified, 17 of which offered home and clinic-based assessment whilst 30 provided clinic-based assessment only. Of the eligible studies, 7 were validated in a PD patient population only, whilst 40 were tested in both PD and healthy control groups. 19 of the 47 technologies assessed bradykinesia only, whereas 28 assessed other parkinsonian features as well. 33 technologies have been described in additional PD-related studies, whereas 14 are not known to have been tested beyond the pilot phase. Conclusion: Technology based tools offer advantages including objective motor assessment and home monitoring of symptoms, and can be used to assess response to intervention in clinical trials or routine care. This review provides an up-to-date repository and synthesis of the current literature regarding technology used for assessing limb bradykinesia in PD. The review also discusses the current trends with regards to technology and discusses future directions in development. PMID:28222539

Health related quality of life assessment in metastatic disease of the spine: a systematic review.

Science.gov (United States)

Street, John; Berven, Sigurd; Fisher, Charles; Ryken, Timothy

2009-10-15

Systematic literature review. To examine the available literature on health related quality of life (HRQOL) assessment in metastatic disease of the spine and identify the optimal functional outcome scales to be used in developing a disease-specific tool. There is a lack of consensus in the use of HRQOL measures in patients with metastatic spine disease. A systematic review was conducted using MEDLINE, EMBASE, the Science Citation Index (ISI), the Cumulative Index to Nursing and Allied Health Literature, the PsycINFO, the Allied and Complementary Medicine (AMED), Cochrane Reviews and Global Health databases for clinical studies addressing metastatic spine disease from 1966 through 2008. The validity of outcome tools was established by linkage analysis with the International Classification of Functioning Disability and Health (ICF). One hundred forty-one clinical studies met inclusion criteria including 10,347 patients. Only 5 moderate grade and 1 high grade study were identified. Thirty- four studies used a patient self-assessment instrument to assess health status. None of the instruments were validated for metastatic spine patients. The most commonly used Pi-by-no tools were SF-36, SIP 5, and the ADL. None of the studies defined health related quality of life (HRQOL) or justified the choice of instrument. The most commonly used cancer-specific tools were ECOG, EORTC QCQ-C30, and EUROQOL 5D. Based on frequency of citation and on correlation with the International Classification of Functioning Disability and Health, the ECOG and SF36 were judged as most valid and reliable. A systematic review of the available evidence suggests that valid and reliable health related quality of life measures exist for the assessment of oncology patients; however, a disease-specific tool for metastatic spine disease awaits development. Until such time as a disease-specific tool is available, we recommend that the ECOG and SF-36 be considered for use in studies addressing the outcome

A preliminary assessment of potential doses to man from radioactive waste dumped in the Arctic Sea

Energy Technology Data Exchange (ETDEWEB)

Nielsen, S P [Forskningscente Risoe, Roskilde (Denmark); Iosjpe, M; Strand, P [Norwegian Radiation Protection Authority, Oesteraas (Norway)

1995-09-01

This report describes a preliminary radiological assessment of collective doses to the world population from radioactive material dumped in the Barents and Kara Seas in the period 1961-1991. Information on the dumped waste and the rates of release of radionuclides have been available from Russian sources and from the International Atomic Energy Agency. A box model has been used to simulate the dispersion of radionuclides in the marine environment and to calculate the contamination of seafood and the subsequent radiation doses to man. Two release scenarios have been adopted. The worst-case release scenario which ignores the presence of barriers between spent nuclear fuel and seawater is estimated to give rise to about 10 mansieverts calculated to 1000 years from the time of release. A more realistic release scenario is estimated to cause about 3 mansieverts. In both cases exposure from the radionuclide {sup 137}Cs is found to dominate the doses. (au) 8 tabs., 56 ills., 19 refs.

An assistive controller for a lower-limb exoskeleton for rehabilitation after stroke, and preliminary assessment thereof.

Science.gov (United States)

Murray, Spencer A; Ha, Kevin H; Goldfarb, Michael

2014-01-01

This paper describes a novel controller, intended for use in a lower-limb exoskeleton, to aid gait rehabilitation in patients with hemiparesis after stroke. The controller makes use of gravity compensation, feedforward movement assistance, and reinforcement of isometric joint torques to achieve assistance without dictating the spatiotemporal nature of joint movement. The patient is allowed to self-select walking speed and is able to make trajectory adaptations to maintain balance without interference from the controller. The governing equations and the finite state machine which comprise the system are described herein. The control architecture was implemented in a lower-limb exoskeleton and a preliminary experimental assessment was conducted in which a patient with hemiparesis resulting from stroke walked with assistance from the exoskeleton. The patient exhibited improvements in fast gait speed, step length asymmetry, and stride length in each session, as measured before and after exoskeleton training, presumably as a result of using the exoskeleton.

A preliminary assessment of potential doses to man from radioactive waste dumped in the Arctic sea

International Nuclear Information System (INIS)

Nielsen, S.P.; Iosjpe, M.; Strand, P.

1995-11-01

This report describes a preliminary radiological assessment of collective doses to the world population from radioactive material dumped in the Kara and Barents Seas in the period 1961-1991. Information on the dumped waste and the rates of release of radionuclides have been available from Russian sources and from the International Atomic Energy Agency. A box model has been used to simulate the dispersion of radionuclides in the marine environment and to calculate the contamination of seafood and the subsequent radiation doses to man. Two release scenarios have been adopted. The worst-case release scenario, which ignores the presence of barriers between spent nuclear fuel and seawater, is estimated to give rise to about 10 mansievert calculated to 1000 years from the time of release. A more realistic release scenario is estimated to cause about 3 mansieverts. In both cases exposure from the radionuclide 137 Cs is found to dominate the doses. 19 refs., 56 figs., 8 tabs

Alternative conceptual models and codes for unsaturated flow in fractured tuff: Preliminary assessments for GWTT-95

International Nuclear Information System (INIS)

Ho, C.K.; Altman, S.J.; Arnold, B.W.

1995-09-01

Groundwater travel time (GWTT) calculations will play an important role in addressing site-suitability criteria for the potential high-level nuclear waste repository at Yucca Mountain,Nevada. In support of these calculations, Preliminary assessments of the candidate codes and models are presented in this report. A series of benchmark studies have been designed to address important aspects of modeling flow through fractured media representative of flow at Yucca Mountain. Three codes (DUAL, FEHMN, and TOUGH 2) are compared in these benchmark studies. DUAL is a single-phase, isothermal, two-dimensional flow simulator based on the dual mixed finite element method. FEHMN is a nonisothermal, multiphase, multidimensional simulator based primarily on the finite element method. TOUGH2 is anon isothermal, multiphase, multidimensional simulator based on the integral finite difference method. Alternative conceptual models of fracture flow consisting of the equivalent continuum model (ECM) and the dual permeability (DK) model are used in the different codes

A preliminary assessment of potential doses to man from radioactive waste dumped in the Arctic Sea

International Nuclear Information System (INIS)

Nielsen, S.P.; Iosjpe, M.; Strand, P.

1995-09-01

This report describes a preliminary radiological assessment of collective doses to the world population from radioactive material dumped in the Barents and Kara Seas in the period 1961-1991. Information on the dumped waste and the rates of release of radionuclides have been available from Russian sources and from the International Atomic Energy Agency. A box model has been used to simulate the dispersion of radionuclides in the marine environment and to calculate the contamination of seafood and the subsequent radiation doses to man. Two release scenarios have been adopted. The worst-case release scenario which ignores the presence of barriers between spent nuclear fuel and seawater is estimated to give rise to about 10 mansieverts calculated to 1000 years from the time of release. A more realistic release scenario is estimated to cause about 3 mansieverts. In both cases exposure from the radionuclide 137 Cs is found to dominate the doses. (au) 8 tabs., 56 ills., 19 refs

Preliminary parametric performance assessment of potential final waste forms for alpha low-level waste at the Idaho National Engineering Laboratory. Revision 1

International Nuclear Information System (INIS)

Smith, T.H.; Sussman, M.E.; Myers, J.; Djordjevic, S.M.; DeBiase, T.A.; Goodrich, M.T.; DeWitt, D.

1995-08-01

This report presents a preliminary parametric performance assessment (PA) of potential waste disposal systems for alpha-contaminated, mixed, low-level waste (ALLW) currently stored at the Transuranic Storage Area of INEL. The ALLW, which contains from 10 to 100 nCi/g of transuranic (TRU) radionuclides, is awaiting treatment and disposal. The purpose of this study was to examine the effects of several parameters on the radiological-confinement performance of potential disposal systems for the ALLW. The principal emphasis was on the performance of final waste forms (FWFs). Three categories of FWF (cement, glass, and ceramic) were addressed by evaluating the performance of two limiting FWFs for each category. Performance at five conceptual disposal sites was evaluated to illustrate the effects of site characteristics on the performance of the total disposal system. Other parameters investigated for effects on receptor dose included inventory assumptions, TRU radionuclide concentration, FWF fracture, disposal depth, water infiltration rates, subsurface-transport modeling assumptions, receptor well location, intrusion scenario assumptions, and the absence of waste immobilization. These and other factors were varied singly and in some combinations. The results indicate that compliance of the treated and disposed ALLW with the performance objectives depends on the assumptions made, as well as on the FWF and the disposal site. Some combinations result in compliance, while others do not. The implications of these results for decision making relative to treatment and disposal of the INEL ALLW are discussed. The report compares the degree of conservatism in this preliminary parametric PA against that in four other PAs and one risk assessment. All of the assessments addressed the same disposal site, but different wastes. The report also presents a qualitative evaluation of the uncertainties in the PA and makes recommendations for further study

Preliminary assessment of beam impact consequences on LHC Collimators

CERN Document Server

Cauchi, M; Bertarelli, A; Bruce, R; Carra, F; Dallocchio, A; Deboy, D; Mariani, N; Rossi, A; Lari, L; Mollicone, P; Sammut, N

2011-01-01

The correct functioning of the LHC collimation system is crucial to attain the desired LHC luminosity performance. However, the requirements to handle high intensity beams can be demanding. In this respect, the robustness of the collimators plays an important role. An accident, which causes the proton beam to hit a collimator, might result in severe beam-induced damage and, in some cases, replacement of the collimator, with consequent downtime for the machine. In this paper, several case studies representing different realistic beam impact scenarios are shown. A preliminary analysis of the thermal response of tertiary collimators to beam impact is presented, from which the most critical cases can be identified. Such work will also help to give an initial insight on the operational constraints of the LHC by taking into account all relevant collimator damage limits.

END STAGE RENAL DISEASE IN PATIENTS WITH WILMS TUMOR: RESULTS FROM THE NATIONAL WILMS TUMOR STUDY GROUP AND THE U.S. RENAL DATA SYSTEM

OpenAIRE

Breslow, Norman E.; Grigoriev, Yevgeny A.; Peterson, Susan M.; Collins, Allan J.; Ritchey, Michael L.; Green, Daniel M.

2005-01-01

Purpose: To accurately assess the full spectrum of end stage renal disease (ESRD) in Wilms tumor survivors by combining the unique resources of the National Wilms Tumor Study Group (NWTSG) and the U.S. Renal Data System (USRDS), and to confirm preliminary reports of an increased incidence of ESRD in those with the Wilms tumor-aniridia (WAGR) syndrome.

Long term outcomes following achievement of clinically inactive disease in juvenile idiopathic arthritis: the importance of definition.

Science.gov (United States)

Shoop-Worrall, Stephanie Jw; Verstappen, Suzanne Mm; McDonagh, Janet E; Baildam, Eileen; Chieng, Alice; Davidson, Joyce; Foster, Helen; Ioannou, Yiannis; McErlane, Flora; Wedderburn, Lucy R; Thomson, W; Hyrich, Kimme L

2018-04-12

Potential targets for treat-to-target strategies in JIA are minimal disease activity (MDA) and clinically inactive disease (CID). Short and long-term outcomes following achievement of MDA and CID on the cJADAS10 and CID on Wallace's preliminary criteria were compared. Children recruited to the Childhood Arthritis Prospective Study, a UK multicentre inception cohort, were selected if recruited prior to January 2011 and diagnosed with oligoarthritis or rheumatoid factor negative or positive polyarthritis. At one year following diagnosis, children were assessed for MDA on the cJADAS10 and CID on both Wallace's preliminary criteria and the cJADAS10. Associations were tested between these disease states and i) functional ability, ii) absence of limited joints, iii) psychosocial health and v) pain at one year and annually to five years. Of 832 children, 70% were female and the majority had oligoarthritis (68%). At one year, 21% had achieved CID according to both definitions, 7% on Wallace's preliminary criteria only, 16% on cJADAS10 only and 56% on neither. Only 10% of children in the entire cohort achieved MDA without also having CID. Achieving either early CID state was associated with greater absence of limited joints. However, only CID on cJADAS10 was associated with improved functional ability and psychosocial health. Achieving CID was superior to MDA in terms of short and long-term pain and the absence of limited joints. CID on the cJADAS10 may be a preferable treatment target to CID on Wallace's preliminary criteria in terms of both feasibility of application and long-term outcomes. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Preliminary investigations for technology assessment of 99Mo production from LEU [low enriched uranium] targets

International Nuclear Information System (INIS)

Vandegrift, G.F.; Chaiko, D.J.; Heinrich, R.R.; Kucera, E.T.; Jensen, K.J.; Poa, D.S.; Varma, R.; Vissers, D.R.

1986-11-01

This paper presents the results of preliminary studies on the effects of substituting low enriched uranium (LEU) for highly enriched uranium (HEU) in targets for the production of fission product 99 Mo. Issues that were addressed are: (1) purity and yield of the 99 Mo//sup 99m/Tc product, (2) fabrication of LEU targets and related concerns, and (3) radioactive waste. Laboratory experimentation was part of the efforts for issues (1) and (2); thus far, radioactive waste disposal has only been addressed in a paper study. Although the reported results are still preliminary, there is reason to be optimistic about the feasibility of utilizing LEU targets for 99 Mo production. 37 refs., 1 fig., 5 tabs

76 FR 63308 - Data and Data Needs To Advance Risk Assessment for Emerging Infectious Diseases Relevant to Blood...

Science.gov (United States)

2011-10-12

...] Data and Data Needs To Advance Risk Assessment for Emerging Infectious Diseases Relevant to Blood and... Needs to Advance Risk Assessment for Emerging Infectious Diseases Relevant to Blood and Blood Products... an important tool for evaluating the risks associated with new emerging infectious diseases (EIDs...

Development of fault parameters for use in risk assessment modeling in the Pasco Basin, Columbia Plateau, South Central Washington: a preliminary study

International Nuclear Information System (INIS)

Caggiano, J.A.

1982-03-01

Preliminary data on strain rate, seismicity, and estimated earthquake source parameters suggest limitations on the extent of postulated faulting and its impact on a nuclear waste repository in Columbia River basalt. Structural relief of dated basalt flows, attitude of Pliocene sediments, geodetic surveys, size and distribution of earthquakes, and focal mechanism solutions indicate that deformation of basalt under north-south compression was under way in the Miocene and has continued on existing structures at an average rate of much less than 1 mm/yr in the Pasco Basin. Lengths and displacements of mapped faults suggest limits on the postulated fault that could intersect a repository and produce an earthquake of about magnitude 6.5. Using a credible earthquake permits calculation of preliminary source parameters for risk assessment modeling during a single episode of slip on the postulated new fault and indicates displacement of less than or equal to 1, m on a steeply dipping fault of less than or equal to 50 km length could occur. Preliminary source parameter calculations suggest that displacements of less than or equal to 2 cm may occur during microearthquakes in swarms. The area of fault rupture may be tens of square meters up to a few square kilometers, suggesting slip on joints. Seismic moments for postulated earthquakes in the interconnecting fault and microearthquake scenarios compare favorably with reported values for similar-sized earthquakes in different media and suggest that the estimated fault parameters are reasonable until an adequate tectonic model has been developed

ASSESSMENT OF LENS THICKNESS IN ANGLE CLOSURE DISEASE

Directory of Open Access Journals (Sweden)

Nishat Sultana Khayoom

2016-08-01

Full Text Available BACKGROUND Anterior chamber depth and lens thickness have been considered as important biometric determinants in primary angle-closure glaucoma. Patients with primary narrow angle may be classified as a primary angle closure suspect (PACS, or as having primary angle closure (PAC or primary angle closure glaucoma (PACG. 23.9% of patients with primary angle closure disease are in India, which highlights the importance of understanding the disease, its natural history, and its underlying pathophysiology, so that we may try to establish effective methods of treatment and preventative measures to delay, or even arrest, disease progression, thereby reducing visual morbidity. AIM To determine the lens thickness using A-scan biometry and its significance in various stages of angle closure disease. MATERIALS AND METHODS Patients attending outpatient department at Minto Ophthalmic Hospital between October 2013 to May 2015 were screened for angle closure disease and subsequently evaluated at glaucoma department. In our study, lens thickness showed a direct correlation with shallowing of the anterior chamber by determining the LT/ ACD ratio. A decrease in anterior chamber depth is proportional to the narrowing of the angle which contributes to the progression of the angle closure disease from just apposition to occlusion enhancing the risk for optic nerve damage and visual field loss. Hence, if the lens thickness values are assessed earlier in the disease process, appropriate intervention can be planned. CONCLUSION Determination of lens changes along with anterior chamber depth and axial length morphometrically can aid in early detection of angle closure. The role of lens extraction for PACG is a subject of increased interest. Lens extraction promotes the benefits of anatomical opening of the angle, IOP reduction and improved vision. This potential intervention may be one among the armamentarium of approaches for PACG. Among the current treatment modalities

Radiological risk assessment of a radioactively contaminated site

International Nuclear Information System (INIS)

Devgun, J.S.

1990-01-01

A limited-scope preliminary assessment of radiological risk has been conducted at a radioactively contaminated site under current site use conditions and based on the available preliminary radiological characterization data for the site. The assessment provides useful input to the remedial action planning for the site. 8 refs., 1 fig., 2 tabs

Diffusion-weighed MR of the thyroid gland in Graves' disease: assessment of disease activity and prediction of outcome.

Science.gov (United States)

Abdel Razek, Ahmed Abdel Khalek; Sadek, Ahmed Galal; Gaballa, Gada

2010-06-01

To assess the activity and clinical course of Graves' disease with diffusion-weighted magnetic resonance (MR) imaging. Fifty-one patients with Graves' disease and 25 volunteers underwent diffusion MR imaging of the thyroid gland using a single shot echo-planar imaging with b-factor of 0, 300 and 600 second/mm(2). The apparent diffusion coefficient (ADC) values of the thyroid gland were calculated. Patients with active Graves' disease included untreated patients at initial diagnosis (n = 12), patients under antithyroid drugs (n = 11), and patients in relapse after withdrawal of therapy (n = 13). Patients with inactive disease had a remission of hyperthyroidism (n = 15). The mean ADC values of thyroid gland with active Graves' disease was 0.65 +/- 0.03 x 10(-3) mm(2)/second in patients at initial diagnosis, 0.81 +/- 0.02 x 10(-3) mm(2)/second in patients undergoing antithyroid drug and 0.72 +/- 0.07 x 10(-3) mm(2)/second in patients with relapse of hyperthyroidism. The mean ADC of patients with remission was 0.94 +/- 0.03 x 10(-3) mm(2)/second and for normal volunteer was 1.06 +/- 0.08 x 10(-3) mm(2)/second. There was significant difference in the ADC value of patients with active disease and remission (P = .001). The cutoff ADC value used for differentiating patients with active disease from patients with remission was 0.82 x 10(-3) mm(2)/second. The mean ADC value of thyroid gland had positive correlation with thyroid-stimulating hormone (r = 0.87, P = .001) and negative correlation with serum T4 (r = -0.82, P = .001) and serum T3 (r = -0.71, P = .001). The ADC value of the thyroid gland is a promising non invasive parameter for diagnosis of different clinical stages of Graves' disease. Hence it can be used to assess the activity and predict the outcome of patients during and after medical treatment. Crown Copyright (c) 2010. Published by Elsevier Inc. All rights reserved.

A preliminary assessment of the potential for 'team science' in DOE Energy Innovation Hubs and Energy Frontier Research Centers

International Nuclear Information System (INIS)

Boardman, Craig; Ponomariov, Branco

2011-01-01

President Obama has called for the development of new energy technologies to address our national energy needs and restore US economic competitiveness. In response, the Department of Energy has established new R and D modalities for energy research and development designed to facilitate collaboration across disciplinary, institutional, and sectoral boundaries. In this research note, we provide a preliminary assessment of the potential for essential mechanisms for coordinated problem solving among diverse actors within two new modalities at the DOE: Energy Innovation Hubs and Energy Frontier Research Centers. - Highlights: → Energy Frontier Research Centers may lack the basic mechanisms for coordinating diverse actors. → Divergent goals across diverse actors may hinder coordination in Energy Innovation Hubs. → The implementation of these and similar energy policies require further investigation.

Standardized Handwriting to Assess Bradykinesia, Micrographia and Tremor in Parkinson's Disease

NARCIS (Netherlands)

Smits, Esther J.; Tolonen, Antti J.; Cluitmans, Luc; van Gils, Mark; Conway, Bernard A.; Zietsma, Rutger C.; Leenders, Klaus L.; Maurits, Natasha M.

2014-01-01

Objective: To assess whether standardized handwriting can provide quantitative measures to distinguish patients diagnosed with Parkinson's disease from age- and gender-matched healthy control participants. Design: Exploratory study. Pen tip trajectories were recorded during circle, spiral and line

Retinal nerve fiber layer and ganglion cell complex thickness assessment in patients with Alzheimer disease and mild cognitive impairment. Preliminary results

Directory of Open Access Journals (Sweden)

A. S. Tiganov

2014-07-01

Full Text Available Purpose: to investigate the retinal nerve fiber layer (RNFL and the macular ganglion cell complex (GCC in patients with Alzheimer`s disease and mild cognitive impairment.Methods: this study included 10 patients (20 eyes with Alzheimer`s disease, 10 patients with mild cognitive impairment and 10 age- and sex-matched healthy controls that had no history of dementia. All the subjects underwent psychiatric examination, including the Mini-Mental State Examination (MMSE, and complete ophthalmological examination, comprising optical coherence tomography and scanning laser polarimetry.Results: there was a significant decrease in GCC thickness in patients with Alzheimer`s disease compared to the control group, global loss volume of ganglion cells was higher than in control group. there was no significant difference among the groups in terms of RNFL thickness. Weak positive correlation of GCC thickness and MMSE results was observed.Conclusion: Our data confirm the retinal involvement in Alzheimer`s disease, as reflected by loss of ganglion cells. Further studies will clear up the role and contribution of dementia in pathogenesis of optic neuropathy.

Digital subtraction angiography in the assessment of cardiovascular disease

International Nuclear Information System (INIS)

Harrington, D.P.; Boxt, L.M.

1985-01-01

Digital subtraction angiography (DSA) is a new radiographic method for evaluating the cardiovascular system. It represents another in a continuing series of computer-assisted diagnostic imaging modalities. The advantages of this technique are its relatively noninvasive nature combined with diagnostically acceptable angiographic images of a variety of cardiovascular structures. Major clinical applications of DSA include its use in imaging of localized regions of peripheral arterial disease and as a screening procedure in evaluating extracranial carotid and vertebral artery disease and renovascular hypertension. Cardiac applications of DSA include assessment of ventricular function, recognition and quantification of intracardiac shunts, visualization of coronary artery bypass grafts, and the study of complex congenital cardiac malformations. Digital subtraction angiography may also be used to evaluate intracranial aneurysms and vascular tumors

Rejoinder to commentary on Palmatier and Rovner (2015): credibility assessment: Preliminary Process Theory, the polygraph process, and construct validity.

Science.gov (United States)

Palmatier, John J; Rovner, Louis

2015-01-01

We briefly review comments submitted in response to the target article in this series (Palmatier & Rovner, 2015) arguing that a scientifically defensible construct for the instrumental assessment of credibility (i.e. polygraph) may be found in Barry's Preliminary Process Theory (PPT). Our review of the relevant scientific literature discovered a growing body of converging evidence, particularly from the neurosciences that focus not only on deception, but more broadly on memory, emotion, and the orienting response (OR), leading to this conclusion. After reviewing the submitted comments, we are further convinced, especially as applied scientists, that at this time the most viable direction forward is in the context of the PPT. Concurrently, we candidly acknowledge that research must be conducted to address not only commentator concerns but, if warranted, modification of existing theory. Although disagreement continues to exist regarding the order in which questions are asked, the most significant finding, is perhaps that not a single commentator argues against this growing, and vital applied science (i.e., the instrumental assessment of credibility - polygraph). Copyright © 2014 Elsevier B.V. All rights reserved.

CRED REA Coral Health and Disease Assessment at Saipan Island, Marianas Archipelago in 2007

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National Oceanic and Atmospheric Administration, Department of Commerce — Coral health and disease assessments were conducted along 2 consecutively placed 25-m transects, as part of Rapid Ecological Assessments conducted at 8 sites at...

CRED REA Coral Health and Disease Assessment at Uracas Island, Marianas Archipelago in 2007

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National Oceanic and Atmospheric Administration, Department of Commerce — Coral health and disease assessments were conducted along 2 consecutively placed 25-m transects, as part of Rapid Ecological Assessments conducted at 3 sites at...

CRED REA Coral Health and Disease Assessment at Asuncion Island, Marianas Archipelago in 2007

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National Oceanic and Atmospheric Administration, Department of Commerce — Coral health and disease assessments were conducted along 2 consecutively placed 25-m transects, as part of Rapid Ecological Assessments conducted at 3 sites at...

CRED REA Coral Health and Disease Assessment at Rose Island, American Samoa in 2008

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Coral health and disease assessments were conducted along 2 consecutively placed 25-m transects, as part of Rapid Ecological Assessments conducted at 12 sites at...

CRED REA Coral Health and Disease Assessment at Sarigan Island, Marianas Archipelago in 2007

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Coral health and disease assessments were conducted along 2 consecutively placed 25-m transects, as part of Rapid Ecological Assessments conducted at 3 sites at...

CRED REA Coral Health and Disease Assessment at Tinian Island, Marianas Archipelago in 2007

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Coral health and disease assessments were conducted along 2 consecutively placed 25-m transects, as part of Rapid Ecological Assessments conducted at 5 sites at...

CRED REA Coral Health and Disease Assessment at Guguan Island, Marianas Archipelago in 2007

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Coral health and disease assessments were conducted along 2 consecutively placed 25-m transects, as part of Rapid Ecological Assessments conducted at 3 sites at...

CRED REA Coral Health and Disease Assessment at Swains Atoll, American Samoa in 2008

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Coral health and disease assessments were conducted along 2 consecutively placed 25-m transects, as part of Rapid Ecological Assessments conducted at 8 sites at...

CRED REA Coral Health and Disease Assessment at Pagan Island, Marianas Archipelago in 2007

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Coral health and disease assessments were conducted along 2 consecutively placed 25-m transects, as part of Rapid Ecological Assessments conducted at 9 sites at...

CRED REA Coral Health and Disease Assessment at Aguijan Island, Marianas Archipelago in 2007

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National Oceanic and Atmospheric Administration, Department of Commerce — Coral health and disease assessments were conducted along 2 consecutively placed 25-m transects, as part of Rapid Ecological Assessments conducted at 1 sites at...

CRED REA Coral Health and Disease Assessment at Alamagan Island, Marianas Archipelago in 2007

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Coral health and disease assessments were conducted along 2 consecutively placed 25-m transects, as part of Rapid Ecological Assessments conducted at 3 sites at...

CRED REA Coral Health and Disease Assessment at Agrihan Island, Marianas Archipelago in 2007

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Coral health and disease assessments were conducted along 2 consecutively placed 25-m transects, as part of Rapid Ecological Assessments conducted at 3 sites at...

CRED REA Coral Health and Disease Assessment at Tutuila Island, American Samoa in 2008

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Coral health and disease assessments were conducted along 2 consecutively placed 25-m transects, as part of Rapid Ecological Assessments conducted at 23 sites at...

An ontology-based approach to patient follow-up assessment for continuous and personalized chronic disease management.

Science.gov (United States)

Zhang, Yi-Fan; Gou, Ling; Zhou, Tian-Shu; Lin, De-Nan; Zheng, Jing; Li, Ye; Li, Jing-Song

2017-08-01

Chronic diseases are complex and persistent clinical conditions that require close collaboration among patients and health care providers in the implementation of long-term and integrated care programs. However, current solutions focus partially on intensive interventions at hospitals rather than on continuous and personalized chronic disease management. This study aims to fill this gap by providing computerized clinical decision support during follow-up assessments of chronically ill patients at home. We proposed an ontology-based framework to integrate patient data, medical domain knowledge, and patient assessment criteria for chronic disease patient follow-up assessments. A clinical decision support system was developed to implement this framework for automatic selection and adaptation of standard assessment protocols to suit patient personal conditions. We evaluated our method in the case study of type 2 diabetic patient follow-up assessments. The proposed framework was instantiated using real data from 115,477 follow-up assessment records of 36,162 type 2 diabetic patients. Standard evaluation criteria were automatically selected and adapted to the particularities of each patient. Assessment results were generated as a general typing of patient overall condition and detailed scoring for each criterion, providing important indicators to the case manager about possible inappropriate judgments, in addition to raising patient awareness of their disease control outcomes. Using historical data as the gold standard, our system achieved a rate of accuracy of 99.93% and completeness of 95.00%. This study contributes to improving the accessibility, efficiency and quality of current patient follow-up services. It also provides a generic approach to knowledge sharing and reuse for patient-centered chronic disease management. Copyright © 2017 Elsevier Inc. All rights reserved.

Hyperpolarized {sup 3}He magnetic resonance imaging: Preliminary evaluation of phenotyping potential in chronic obstructive pulmonary disease

Energy Technology Data Exchange (ETDEWEB)

Mathew, Lindsay, E-mail: lmathew@imaging.robarts.ca [Imaging Research Laboratories, Robarts Research Institute, London (Canada); Department of Medical Biophysics, University of Western Ontario, London (Canada); Kirby, Miranda, E-mail: mkirby@imaging.robarts.ca [Imaging Research Laboratories, Robarts Research Institute, London (Canada); Department of Medical Biophysics, University of Western Ontario, London (Canada); Etemad-Rezai, Roya, E-mail: Roya.EtemadRezai@lhsc.on.ca [Department of Medical Imaging, University of Western Ontario (Canada); Wheatley, Andrew, E-mail: awheat@imaging.robarts.ca [Imaging Research Laboratories, Robarts Research Institute, London (Canada); McCormack, David G., E-mail: David.McCormack@lhsc.on.ca [Imaging Research Laboratories, Robarts Research Institute, London (Canada); Division of Respirology, Department of Medicine, University of Western Ontario, London (Canada); Lawson Health Research Institute, London (Canada); Parraga, Grace, E-mail: gep@imaging.robarts.ca [Imaging Research Laboratories, Robarts Research Institute, London (Canada); Department of Medical Biophysics, University of Western Ontario, London (Canada); Department of Medical Imaging, University of Western Ontario (Canada); Lawson Health Research Institute, London (Canada)

2011-07-15

Rationale and objectives: Emphysema and small airway obstruction are the pathological hallmarks of chronic obstructive pulmonary disease (COPD). The aim of this pilot study in a small group of chronic obstructive pulmonary disease (COPD) patients was to quantify hyperpolarized helium-3 ({sup 3}He) magnetic resonance imaging (MRI) functional and structural measurements and to explore the potential role for {sup 3}He MRI in detecting the lung structural and functional COPD phenotypes. Materials and methods: We evaluated 20 ex-smokers with stage I (n = 1), stage II (n = 9) and stage III COPD (n = 10). All subjects underwent same-day plethysmography, spirometry, {sup 1}H MRI and hyperpolarized {sup 3}He MRI at 3.0 T. {sup 3}He ventilation defect percent (VDP) was generated from {sup 3}He static ventilation images and {sup 1}H thoracic images and the {sup 3}He apparent diffusion coefficient (ADC) was derived from diffusion-weighted MRI. Results: Based on the relative contribution of normalized ADC and VDP, there was evidence of a predominant {sup 3}He MRI measurement in seven patients (n = 3 mainly ventilation defects or VDP dominant (VD), n = 4 mainly increased ADC or ADC dominant (AD)). Analysis of variance (ANOVA) showed significantly lower ADC for subjects with predominantly elevated VDP (p = 0.02 compared to subjects with predominantly elevated ADC; p = 0.008 compared to mixed group) and significantly decreased VDP for subjects with predominantly elevated ADC (p = 0.003, compared to mixed group). Conclusion: In this small pilot study, a preliminary analysis shows the potential for {sup 3}He MRI to categorize or phenotype COPD ex-smokers, providing good evidence of feasibility for larger prospective studies.

Development of an Ergonomics Checklist for Investigation of Work-Related Whole-Body Disorders in Farming - AWBA: Agricultural Whole-Body Assessment.

Science.gov (United States)

Kong, Y K; Lee, S J; Lee, K S; Kim, G R; Kim, D M

2015-10-01

Researchers have been using various ergonomic tools to study occupational musculoskeletal diseases in industrial contexts. However, in agricultural work, where the work environment is poorer and the socio-psychological stress is high due to the high labor intensities of the industry, current research efforts have been scarce, and the number of available tools is small. In our preliminary studies, which focused on a limited number of body parts and other working elements, we developed separate evaluation tools for the upper and lower extremities. The current study was conducted to develop a whole-body ergonomic assessment tool for agricultural work that integrates the existing assessment tools for lower and upper extremities developed in the preliminary studies and to verify the relevance of the integrated assessment tool. To verify the relevance of the Agricultural Whole-Body Assessment (AWBA) tool, we selected 50 different postures that occur frequently in agricultural work. Our results showed that the AWBA-determined risk levels were similar to the subjective risk levels determined by experts. In addition, as the risk level increased, the average risk level increased to a similar extent. Moreover, the differences in risk levels between the AWBA and expert assessments were mostly smaller than the differences in risk levels between other assessment tools and the expert assessments in this study. In conclusion, the AWBA tool developed in this study was demonstrated to be appropriate for use as a tool for assessing various postures commonly assumed in agricultural work. Moreover, we believe that our verification of the assessment tools will contribute to the enhancement of the quality of activities designed to prevent and control work-related musculoskeletal diseases in other industries.

Quality assessment of diagnosis and antibiotic treatment of infectious diseases in primary care

DEFF Research Database (Denmark)

Saust, Laura Trolle; Monrad, Rikke Nygaard; Hansen, Malene Plejdrup

2016-01-01

QIs, especially disease-specific QIs concerning the diagnostic process, is needed. KEY POINTS In order to improve the use of antibiotics in primary care, measurable instruments, such as quality indicators, are needed to assess the quality of care being provided. A total of 11 studies were found......OBJECTIVE: To identify existing quality indicators (QIs) for diagnosis and antibiotic treatment of patients with infectious diseases in primary care. DESIGN: A systematic literature search was performed in PubMed and EMBASE. We included studies with a description of the development of QIs...... for diagnosis and antibiotic use in patients with infectious diseases in primary care. We extracted information about (1) type of infection; (2) target for quality assessment; (3) methodology used for developing the QIs; and (4) whether the QIs were developed for a national or international application. The QIs...

CRED REA Coral Health and Disease Assessment at Rota Island, Marianas Archipelago in 2007

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Coral health and disease assessments were conducted along 2 consecutively placed 25-m transects, as part of Rapid Ecological Assessments conducted at 6 sites at Rota...

CRED REA Coral Health and Disease Assessment at Oahu, Main Hawaiian Islands in 2006

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Coral health and disease assessments were conducted along 2 consecutively placed 25-m transects, as part of Rapid Ecological Assessments conducted at 2 sites at Oahu...

CRED REA Coral Health and Disease Assessment at Maug Island, Marianas Archipelago in 2007

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Coral health and disease assessments were conducted along 2 consecutively placed 25-m transects, as part of Rapid Ecological Assessments conducted at 9 sites at Maug...

Multiparametric magnetic resonance imaging for the assessment of non-alcoholic fatty liver disease severity.

Science.gov (United States)

Pavlides, Michael; Banerjee, Rajarshi; Tunnicliffe, Elizabeth M; Kelly, Catherine; Collier, Jane; Wang, Lai Mun; Fleming, Kenneth A; Cobbold, Jeremy F; Robson, Matthew D; Neubauer, Stefan; Barnes, Eleanor

2017-07-01

The diagnosis of non-alcoholic steatohepatitis and fibrosis staging are central to non-alcoholic fatty liver disease assessment. We evaluated multiparametric magnetic resonance in the assessment of non-alcoholic steatohepatitis and fibrosis using histology as standard in non-alcoholic fatty liver disease. Seventy-one patients with suspected non-alcoholic fatty liver disease were recruited within 1 month of liver biopsy. Magnetic resonance data were used to define the liver inflammation and fibrosis score (LIF 0-4). Biopsies were assessed for steatosis, lobular inflammation, ballooning and fibrosis and classified as non-alcoholic steatohepatitis or simple steatosis, and mild or significant (Activity ≥2 and/or Fibrosis ≥2 as defined by the Fatty Liver Inhibition of Progression consortium) non-alcoholic fatty liver disease. Transient elastography was also performed. Magnetic resonance success rate was 95% vs 59% for transient elastography (Pliver inflammation and fibrosis (r s =.51, Pliver inflammation and fibrosis for the diagnosis of cirrhosis was 0.85. Liver inflammation and fibrosis score for ballooning grades 0, 1 and 2 was 1.2, 2.7 and 3.5 respectively (Pliver inflammation and fibrosis (1.3) compared to patients with non-alcoholic steatohepatitis (3.0) (PLiver inflammation and fibrosis scores for patients with mild and significant non-alcoholic fatty liver disease were 1.2 and 2.9 respectively (Pliver inflammation and fibrosis for the diagnosis of significant non-alcoholic fatty liver disease was 0.89. Multiparametric magnetic resonance is a promising technique with good diagnostic accuracy for non-alcoholic fatty liver disease histological parameters, and can potentially identify patients with non-alcoholic steatohepatitis and cirrhosis. © 2017 The Authors Liver International Published by John Wiley & Sons Ltd.

Joint assessment in von Willebrand disease : Validation of the Haemophilia Joint Health score and Haemophilia Activities List

NARCIS (Netherlands)

van Galen, Karin P. M.; Timmer, Merel A.; de Kleijn, Piet; Fischer, Kathelijn; Foppen, Wouter; Schutgens, Roger E. G.; Eikenboom, Jeroen; Meijer, Karina; Cnossen, Marjon H.; Fijnvandraat, Karin; van der Bom, Johanna G.; Laros-van Gorkom, Britta A. P.; Leebeek, Frank W. G.; Mauser-Bunschoten, Eveline P.

Assessment of clinical outcome after joint bleeding is essential to identify joint damage and optimise treatment, to prevent disability. However, disease-specific tools to assess the musculoskeletal status in patients with von Willebrand disease (VWD) are lacking. We aimed to determine validity and

Preliminary Design of Aerial Spraying System for Microlight Aircraft

Science.gov (United States)

Omar, Zamri; Idris, Nurfazliawati; Rahim, M. Zulafif

2017-10-01

Undoubtedly agricultural is an important sector because it provides essential nutrients for human, and consequently is among the biggest sector for economic growth worldwide. It is crucial to ensure crops production is protected from any plant diseases and pests. Thus aerial spraying system on crops is developed to facilitate farmers to for crops pests control and it is very effective spraying method especially for large and hilly crop areas. However, the use of large aircraft for aerial spaying has a relatively high operational cost. Therefore, microlight aircraft is proposed to be used for crops aerial spraying works for several good reasons. In this paper, a preliminary design of aerial spraying system for microlight aircraft is proposed. Engineering design methodology is adopted in the development of the aerial sprayer and steps involved design are discussed thoroughly. A preliminary design for the microlight to be attached with an aerial spraying system is proposed.

Iron in hereditary retinal degeneration: PIXE microanalysis Preliminary results

International Nuclear Information System (INIS)

Sergeant, C.; Gouget, B.; Llabador, Y.; Simonoff, M.; Yefimova, M.; Courtois, Y.; Jeanny, J.C.

1999-01-01

Several types of hereditary retinal degeneration with progressive alteration of photoreceptors exist in men and animals. Recent immunohistochemical results have shown strong degradation of transferrin, the protein responsible for iron transport, in retinas of rats with hereditary retinal degeneration. Freeze-dried thin sections of rat retinas from different stages of the disease, and respective coeval control sections, have been analyzed using nuclear microprobe. In this first part of the study, the rat retinas at post-natal stages of 35 and 45 days have been analyzed. The sample preparation and the post-irradiation staining to determine precisely the retinal layers involved are described. Preliminary results of element distributions (K, Ca, Fe) in the rat retina layers are discussed. A very high content of calcium in the choriocapillaris of dystrophic rat retinas was observed. Preliminary results on iron distribution in the rat retina layers are presented

A preliminary assessment of the Nactus pelagicus species group (Squamata: Gekkonidae) in New Guinea and a new species from the Admiralty Islands

Science.gov (United States)

Zug, George R.; Fisher, Robert N.

2012-01-01

The Slender-toed Geckos (Nactus) currently have four recognized species in New Guinea, and these species divide into two sister clades: a pelagicus clade and a vankampeni clade (Heinicke et al. 2010). The latter contains three dwarf species. The former consists of five bisexual populations, of which numerous New Guinea populations are uncharacterized nomenclaturally and lumped under the epithet ‘pelagicus.’ This report and description of a new species of the pelagicus group from Manus Island in the Admiralty Islands encourages us to offer a preliminary assessment of morphology and diversity in New Guinea ‘pelagicus’ populations.

Therapy assessment in prostate cancer using choline and PSMA PET/CT

Energy Technology Data Exchange (ETDEWEB)

Ceci, Francesco; Castellucci, Paolo; Fanti, Stefano [University of Bologna, Nuclear Medicine Unit, S. Orsola-Malpighi University Hospital, Bologna (Italy); Herrmann, Ken [University Hospital Essen, Department of Nuclear Medicine, Essen (Germany); University of California Los Angeles, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, Los Angeles, CA (United States); Hadaschik, Boris [University Hospital Essen, Department of Urology, Essen (Germany)

2017-08-15

While PET with non-FDG tracers (mainly choline and Ga-PSMA) has commonly been used for restaging in men with biochemically recurrent prostate cancer, as well as for primary staging, it is only recently that a few preliminary studies have addressed the possible use of PET for monitoring the response to systemic therapy of metastatic disease, especially innovative treatments such as abiraterone and enzalutamide. This article aims to evaluate the role of PET imaging with different non-FDG radiotracers for assessment of therapy in advanced prostate cancer patients. (orig.)

ANSI/ASHRAE/IES Standard 90.1-2013 Preliminary Determination: Quantitative Analysis

Energy Technology Data Exchange (ETDEWEB)

Halverson, Mark A.; Rosenberg, Michael I.; Wang, Weimin; Zhang, Jian; Mendon, Vrushali V.; Athalye, Rahul A.; Xie, YuLong; Hart, Reid; Goel, Supriya

2014-03-01

This report provides a preliminary quantitative analysis to assess whether buildings constructed according to the requirements of ANSI/ASHRAE/IES Standard 90.1-2013 would result in energy savings compared with buildings constructed to ANSI/ASHRAE/IES Standard 90.1-2010.

Pattern of breast diseases: preliminary report of breast clinic

International Nuclear Information System (INIS)

Siddiqui, K.; Rasool, I.

2001-01-01

Objective: To find out the pattern of breast disease in this part of the county and create public awareness about breast diseases especially cancer. Design: Ac cross sectional and cohort study. Place and Duration of Study: The study was conducted at Department of Surgery, Jinnah Hospital /Allama Iqbal Medical College, Lahore from March 1999 to July 2000. Subjects and Methods: All the female patients reported were included in this study. They were diagnosed by history, physical examination and rel event investigations like ultrasonography, mammography, FNAS and biopsy. Appropriate medical and surgical management was carried out. The breast cancer was treated according to TNA staging system by multidisciplinary approach. Method of breast self examination (BSE) was taught with the help of charts and brochures. Results: The age ranged from 10 years to 75 years. Maximum number of patients (30%) was seen between 20-29 years of age while 15 (1%) cases did not suffer from any disease. Among 1485 patients the common conditions were non cyclical mastalgia in 362 (24.37%), fibroadenoma in 289 (19.46%), fibrocystic disease in 276(17.98%) breast abscess in 149 (10%) and breast cancer (6.19%). Other diseases were puberty mastitis 49(3.2%), galactocele 40(2.69%), accessory breast 45(3%) and nipple discharge 28(1.88%). Among the palpable lumps, breast caner accounted for 11.75%. The commonest age of presentation of breast cancer was 5th decade (31%) followed by 4th decade (26%). Majority of cancer patients (45%) presented in stage III. All the women with beast abscesses were lactating. Non cyclical mastalgia was commonly seen in 4th decade (30.66%) while 44.63% patients of fibroadenoma reported in the 2nd decade. Fibrocystic disease was reported between 3rd and 4th decade (62.17%). Conclusion: Commonest being conditions were non cyclical mastalgia followed by fibroadenoma while breast cancer contributed a significant percentage of palpable lumps. Due to effective public awareness

Engineering a mobile health tool for resource-poor settings to assess and manage cardiovascular disease risk: SMARThealth study.

Science.gov (United States)

Raghu, Arvind; Praveen, Devarsetty; Peiris, David; Tarassenko, Lionel; Clifford, Gari

2015-04-29

The incidence of chronic diseases in low- and middle-income countries is rapidly increasing both in urban and rural regions. A major challenge for health systems globally is to develop innovative solutions for the prevention and control of these diseases. This paper discusses the development and pilot testing of SMARTHealth, a mobile-based, point-of-care Clinical Decision Support (CDS) tool to assess and manage cardiovascular disease (CVD) risk in resource-constrained settings. Through pilot testing, the preliminary acceptability, utility, and efficiency of the CDS tool was obtained. The CDS tool was part of an mHealth system comprising a mobile application that consisted of an evidence-based risk prediction and management algorithm, and a server-side electronic medical record system. Through an agile development process and user-centred design approach, key features of the mobile application that fitted the requirements of the end users and environment were obtained. A comprehensive analytics framework facilitated a data-driven approach to investigate four areas, namely, system efficiency, end-user variability, manual data entry errors, and usefulness of point-of-care management recommendations to the healthcare worker. A four-point Likert scale was used at the end of every risk assessment to gauge ease-of-use of the system. The system was field-tested with eleven village healthcare workers and three Primary Health Centre doctors, who screened a total of 292 adults aged 40 years and above. 34% of participants screened by health workers were identified by the CDS tool to be high CVD risk and referred to a doctor. In-depth analysis of user interactions found the CDS tool feasible for use and easily integrable into the workflow of healthcare workers. Following completion of the pilot, further technical enhancements were implemented to improve uptake of the mHealth platform. It will then be evaluated for effectiveness and cost-effectiveness in a cluster randomized

Dynamic gadolinium-enhanced subtraction MR imaging - a simple technique for the early diagnosis of Legg-Calve-Perthes disease: preliminary results

International Nuclear Information System (INIS)

Sebag, G.; Ducou Le Pointe, H.; Klein, I.; Maiza, D.; Mazda, K.; Bensahel, H.; Hassan, M.

1997-01-01

To determine whether the simple technique of dynamic gadolinium-enhanced subtraction MR imaging, which is available on standard MR units, can detect ischemia of the femoral head in children with early Legg-Calve-Perthes disease (LCP). Bone perfusion of eight hips in four patients (mean age 7.5 years) was studied using dynamic gadolinium-enhanced substraction MR imaging at the onset of proven LCP (with initial negative plain films). Enhancement of subtracted images was compared with that on standard MR images and with bone scintigraphy findings. Subtraction MR imaging depicted ischemia as a widespread absence of enhancement and was in good agreement with bone scintigraphy. The subtraction technique improved the sensitivity and the specificity of MR imaging in two children. Furthermore, subtraction MR imaging allowed recognition of the pattern of early reperfusion. Our preliminary results indicate that dynamic gadolinium-enhanced subtraction MRI is a simple and promising means of early recognition of ischemia in LCP. (orig.)

Recommendations for ICT use in Alzheimer's disease assessment: Monaco CTAD Expert Meeting.

Science.gov (United States)

Robert, P H; Konig, A; Andrieu, S; Bremond, F; Chemin, I; Chung, P C; Dartigues, J F; Dubois, B; Feutren, G; Guillemaud, R; Kenisberg, P A; Nave, S; Vellas, B; Verhey, F; Yesavage, J; Mallea, P

2013-01-01

Alzheimer disease (AD) and other related dementia represent a major challenge for health care systems within the aging population. It is therefore important to develop better instruments for assessing disease severity and disease progression to optimize patient's care and support to care providers, and also provide better tools for clinical research. In this area, Information and Communication Technologies (ICT) are of particular interest. Such techniques enable accurate and standardized assessments of patients' performance and actions in real time and real life situations. The aim of this article is to provide basic recommendation concerning the development and the use of ICT for Alzheimer's disease and related disorders. During he ICT and Mental Health workshop (CTAD meeting held in Monaco on the 30th October 2012) an expert panel was set up to prepare the first recommendations for the use of ICT in dementia research. The expert panel included geriatrician, epidemiologist, neurologist, psychiatrist, psychologist, ICT engineers, representatives from the industry and patient association. The recommendations are divided into three sections corresponding to 1/ the clinical targets of interest for the use of ICT, 2/ the conditions, the type of sensors and the outputs (scores) that could be used and obtained, 3/ finally the last section concerns specifically the use of ICT within clinical trials.

Chronic motor cortex stimulation in patients with advanced Parkinson's disease and effects on striatal dopaminergic transmission as assessed by 123I-FP-CIT SPECT: a preliminary report.

Science.gov (United States)

Di Giuda, Daniela; Calcagni, Maria L; Totaro, Manuela; Cocciolillo, Fabrizio; Piano, Carla; Soleti, Francesco; Fasano, Alfonso; Cioni, Beatrice; Bentivoglio, Anna R; Giordano, Alessandro

2012-09-01

The objective of this study was to assess striatal dopamine transporter availability in patients with advanced Parkinson's disease (PD) before and after 13 months of unilateral extradural motor cortex stimulation (EMCS) with [123I]N-ω-fluoropropyl-2-β-carbo-methoxy-3-β-(4-iodophenyl)nortropane single photon emission computed tomography (123I-FP-CIT SPECT). Six PD patients (five women and one man, aged 63.2 ± 5.6 years) underwent 123I-FP-CIT SPECT and clinical evaluation [Unified Parkinson's Disease Rating Scale (UPDRS) and Parkinson's Disease Quality of Life Scale (PDQL)] preoperatively, 8 and 13 months after EMCS. Striatum-to-occipital cortex, caudate-to-occipital cortex and putamen-to-occipital cortex 123I-FP-CIT uptake ratios were calculated using the region of interest method. Total and part III UPDRS scores significantly decreased at 8 and 13 months after stimulation (P=0.02 and 0.04, respectively); UPDRS part II and PDQL scores improved after 13 months (P=0.02 and 0.04, respectively). No significant differences in 123I-FP-CIT uptake ratios between baseline and follow-up were found in the examined regions. However, a progressive reduction in 123I-FP-CIT uptake ratios in the striatum contralateral to the implant was found. In contrast, no further decrease in 123I-FP-CIT uptake ratios was detected in the striatum ipsilateral to the implant. There were no correlations between changes in 123I-FP-CIT uptake ratios with disease duration, changes in medication dosage and motor UPDRS scores. Despite a small but highly selected sample of advanced PD patients, our results showed that no further dopamine transporter reduction occurred in the striatum ipsilateral to the implant side. This finding could lead to the hypothesis that EMCS might elicit a 'neuroprotective' effect, as suggested by significant clinical benefits.

Assessment of two-way relationship between periodontal disease and gestational diabetes mellitus: A case-control study.

Science.gov (United States)

Kalra, Monika; Tangade, Pradeep; Punia, Himanshu; Gupta, Vipul; Sharma, Hunny; Jain, Ankita

2016-01-01

Gestational diabetes mellitus (GDM) is glucose intolerance which begins during pregnancy. Few studies have examined the association between periodontal disease and GDM. The aim of this study was to assess the association between periodontal disease and GDM. The study population comprised ninety patients, out of which thirty were cases and sixty were controls. All cases underwent a laboratory screening test for GDM between 24 and 30 weeks of gestation based on the recommendation of the obstetricians and gynecologists. To assess the periodontal status, a full-mouth periodontal examination assessing the probing depth, periodontal depth, bleeding on probing, clinical attachment level, and gingival recession was performed on all study participants by a single trained examiner. Tests for associations were performed using Chi-square statistics and multivariate logistic regression analysis. None of the periodontitis conditions was found to be a significant predictor of GDM. In GDM patients, 70% of females were having periodontal disease whereas non-GDM patients 77% of patient had periodontal disease. The present study did not show any positive association between periodontal disease and GDM.

Nuclear Reactor Component Code CUPID-I: Numerical Scheme and Preliminary Assessment Results

International Nuclear Information System (INIS)

Cho, Hyoung Kyu; Jeong, Jae Jun; Park, Ik Kyu; Kim, Jong Tae; Yoon, Han Young

2007-12-01

A component scale thermal hydraulic analysis code, CUPID (Component Unstructured Program for Interfacial Dynamics), is being developed for the analysis of components of a nuclear reactor, such as reactor vessel, steam generator, containment, etc. It adopted three-dimensional, transient, two phase and three-field model. In order to develop the numerical schemes for the three-field model, various numerical schemes have been examined including the SMAC, semi-implicit ICE, SIMPLE, Row Scheme and so on. Among them, the ICE scheme for the three-field model was presented in the present report. The CUPID code is utilizing unstructured mesh for the simulation of complicated geometries of the nuclear reactor components. The conventional ICE scheme that was applied to RELAP5 and COBRA-TF, therefore, were modified for the application to the unstructured mesh. Preliminary calculations for the unstructured semi-implicit ICE scheme have been conducted for a verification of the numerical method from a qualitative point of view. The preliminary calculation results showed that the present numerical scheme is robust and efficient for the prediction of phase changes and flow transitions due to a boiling and a flashing. These calculation results also showed the strong coupling between the pressure and void fraction changes. Thus, it is believed that the semi-implicit ICE scheme can be utilized for transient two-phase flows in a component of a nuclear reactor

Nuclear Reactor Component Code CUPID-I: Numerical Scheme and Preliminary Assessment Results

Energy Technology Data Exchange (ETDEWEB)

Cho, Hyoung Kyu; Jeong, Jae Jun; Park, Ik Kyu; Kim, Jong Tae; Yoon, Han Young

2007-12-15

A component scale thermal hydraulic analysis code, CUPID (Component Unstructured Program for Interfacial Dynamics), is being developed for the analysis of components of a nuclear reactor, such as reactor vessel, steam generator, containment, etc. It adopted three-dimensional, transient, two phase and three-field model. In order to develop the numerical schemes for the three-field model, various numerical schemes have been examined including the SMAC, semi-implicit ICE, SIMPLE, Row Scheme and so on. Among them, the ICE scheme for the three-field model was presented in the present report. The CUPID code is utilizing unstructured mesh for the simulation of complicated geometries of the nuclear reactor components. The conventional ICE scheme that was applied to RELAP5 and COBRA-TF, therefore, were modified for the application to the unstructured mesh. Preliminary calculations for the unstructured semi-implicit ICE scheme have been conducted for a verification of the numerical method from a qualitative point of view. The preliminary calculation results showed that the present numerical scheme is robust and efficient for the prediction of phase changes and flow transitions due to a boiling and a flashing. These calculation results also showed the strong coupling between the pressure and void fraction changes. Thus, it is believed that the semi-implicit ICE scheme can be utilized for transient two-phase flows in a component of a nuclear reactor.

Assessing the influence of consanguinity on congenital heart disease

Directory of Open Access Journals (Sweden)

Alan H Bittles

2011-01-01

Full Text Available Numerous articles have been published linking consanguineous marriage to an elevated prevalence of congenital heart disease, with ventricular septal defects and atrial septal defects the most commonly cited disorders. While initially persuasive, on closer examination many of these studies have fundamental shortcomings in their design and in the recruitment of study subjects and controls. Improved matching of cases and controls, to include recognition of the long-established community boundaries within which most marriages are contracted, and the assessment of consanguinity within specific levels and types of marital union would improve and help to focus the study outcomes. At the same time, major discrepancies between studies in their reported prevalence and types of congenital heart disease suggest an urgent need for greater standardization in the classification and reporting of these disorders.

Assessing the influence of consanguinity on congenital heart disease

International Nuclear Information System (INIS)

Bittles, Alan H.

2011-01-01

Numerous articles have been published linking consanguineous marriage to an elevated prevalence of congenital heart disease, with ventricular septal defects and atrial septal defects the most commonly cited disorders. While initially persuasive, on closer examination many of these studies have fundamental shortcomings in their design and in the recruitment of study subjects and controls. Improved matching of cases and controls, to include recognition of the long-established community boundaries within which most marriages are contracted, and the assessment of consanguinity within specific levels and types of marital union would improve and help to focus the study outcomes. At the same time, major discrepancies between studies in their reported prevalence and types of congenital heart disease suggest an urgent need for greater standardization in the classification and reporting of these disorders

Assessment of Climate Change and Vector-borne Diseases in the United States

Science.gov (United States)

Monaghan, A. J.; Beard, C. B.; Eisen, R. J.; Barker, C. M.; Garofalo, J.; Hahn, M.; Hayden, M.; Ogden, N.; Schramm, P.

2016-12-01

Vector-borne diseases are illnesses that are transmitted by vectors, which include mosquitoes, ticks, and fleas. The seasonality, distribution, and prevalence of vector-borne diseases are influenced significantly by climate factors, primarily high and low temperature extremes and precipitation patterns. In this presentation we summarize key findings from Chapter 5 ("Vector-borne Diseases") of the recently published USGCRP Scientific Assessment of the Impacts of Climate Change on Human Health in the United States. Climate change is expected to alter geographic and seasonal distributions of vectors and vector-borne diseases, leading to earlier activity and northward range expansion of ticks capable of carrying the bacteria that cause Lyme disease and other pathogens, and influencing the distribution, abundance and prevalence of infection in mosquitoes that transmit West Nile virus and other pathogens. The emergence or reemergence of vector-borne pathogens is also likely.

Cognitive, functional and behavioral assessment: Alzheimer's disease

Directory of Open Access Journals (Sweden)

Márcia L.F. Chaves

Full Text Available Abstract A review of the evidence on cognitive, functional and behavioral assessment for the diagnosis of dementia due to Alzheimer's disease (AD is presented with revision and broadening of the recommendations on the use of tests and batteries in Brazil for the diagnosis of dementia due to AD. A systematic review of the literature (MEDLINE, LILACS and SCIELO database was carried out by a panel of experts. Studies on the validation and/or adaptation of tests, scales and batteries for the Brazilian population were analyzed and classified according to level of evidence. There were sufficient data to recommend the IQCODE, DAFS-R, DAD, ADL-Q and Bayer scale for the evaluation of instrumental activities of daily living, and the Katz scale for the assessment of basic activities of daily living. For the evaluation of neuropsychiatric symptoms, the Neuropsychiatric Inventory (NPI and the CAMDEX were found to be useful, as was the Cornell scale for depression in dementia. The Mini-Mental State Examination has clinical utility as a screening test, as do the multifunctional batteries (CAMCOG-R, ADAS-COG, CERAD and MDRS for brief evaluations of several cognitive domains. There was sufficient evidence to recommend the CDR scale for clinical and severity assessment of dementia. Tests for Brazilian Portuguese are recommended by cognitive domain based on available data.

Discordance Between Physician Assessment and Patient-Reported Depressive Symptoms in Parkinson Disease.

Science.gov (United States)

Lachner, Christian; Armstrong, Melissa J; Gruber-Baldini, Ann L; Rezvani, Zahra; Reich, Stephen G; Fishman, Paul S; Salazar, Richard; Shulman, Lisa M

2017-07-01

To assess concordance between physician assessment and patient-reported symptoms when screening for depression in Parkinson disease (dPD). Depression in Parkinson disease is highly prevalent (∼40%) and has a significant impact on quality of life and disability, yet physician recognition and treatment remain inadequate. One thousand seventy-six patients with PD completed the Brief Symptom Inventory-18 (BSI-18), a screening questionnaire for psychiatric symptoms, which was compared to item #3 (depression) on the Unified Parkinson's Disease Rating Scale (UPDRS). The mean BSI-18 depression score was 51.4 (9.7). Of the 170 (16%) patients screening positive for dPD on the BSI-18, 104 (61%) were not recognized as depressed by neurologists on the UPDRS. Factors associated with lower neurologist recognition included male gender, better mental health quality of life, and lack of antidepressant use. More than 60% of patients screening positive for depression on self-report were not recognized by neurologists on the UPDRS. A patient-reported screening tool for depression may improve recognition and management of dPD.

Deep learning-based features of breast MRI for prediction of occult invasive disease following a diagnosis of ductal carcinoma in situ: preliminary data

Science.gov (United States)

Zhu, Zhe; Harowicz, Michael; Zhang, Jun; Saha, Ashirbani; Grimm, Lars J.; Hwang, Shelley; Mazurowski, Maciej A.

2018-02-01

Approximately 25% of patients with ductal carcinoma in situ (DCIS) diagnosed from core needle biopsy are subsequently upstaged to invasive cancer at surgical excision. Identifying patients with occult invasive disease is important as it changes treatment and precludes enrollment in active surveillance for DCIS. In this study, we investigated upstaging of DCIS to invasive disease using deep features. While deep neural networks require large amounts of training data, the available data to predict DCIS upstaging is sparse and thus directly training a neural network is unlikely to be successful. In this work, a pre-trained neural network is used as a feature extractor and a support vector machine (SVM) is trained on the extracted features. We used the dynamic contrast-enhanced (DCE) MRIs of patients at our institution from January 1, 2000, through March 23, 2014 who underwent MRI following a diagnosis of DCIS. Among the 131 DCIS patients, there were 35 patients who were upstaged to invasive cancer. Area under the ROC curve within the 10-fold cross-validation scheme was used for validation of our predictive model. The use of deep features was able to achieve an AUC of 0.68 (95% CI: 0.56-0.78) to predict occult invasive disease. This preliminary work demonstrates the promise of deep features to predict surgical upstaging following a diagnosis of DCIS.

Preliminary Assessment for the Effects of the External Hazard Factors on the Safety of NPPs

International Nuclear Information System (INIS)

Jin, So Beom; Hyun, Seung Gyu; Kim, Sang Yun; Lee, Sung Kyu; Hur, Youl

2010-01-01

The Ch.etsu Offshore Earthquake(2007.7.16) in Japan caused damage to the Kashiwazaki-Kariwa(K-K) Nuclear Power Plants (NPPs) with seismic ground motion that exceeded the design level. This incident drew the interest of the safety evaluation studies for NPPs subjected to earthquakes exceeding the design basis around the world. Also, the Indian Ocean Tsunami(2004.12.26) tripped the Madras NPP by reason of flooding of the intake pump house and inundated the construction site of a fast breeder reactor site in India. In addition, from the various man-made and natural hazards such as the oil spill accident near Mallipo, Taean, Chungnam (2007.12), the forest fire near the Ulchin NPP site, the several inflows of marine organism into the intake of the Ulchin NPP, it was confirmed that the safety of NPPs may be affected by natural and human induced disasters. Intergovernmental Panel on Climate Change (IPCC) has been warned about global warming; the average temperature rose about 1.5 .deg. C during the 20th century and the damages caused by typhoons and heavy rains have also increased in Korea. Accordingly, a natural disaster prevention research team(hereafter team) ,which have been organized and operated since 2009, has assessed the impact of various hazards such as earthquakes and environmental changes due to global warming on the safety of NPP and has discussed to establish countermeasures. This paper introduces that the preliminary assessment for the effects of the external hazard factors on the safety of NPPs was conducted by the team

Treating kleptomania: Cross-cultural adaptation of the kleptomania symptom assessment scale and assessment of an outpatient program

OpenAIRE

Christianini, AR; Conti, MA; Hearst, N; Cordás, TA; De Abreu, CN; Tavares, H

2015-01-01

© 2014 Elsevier Inc. All rights reserved. Background Kleptomania is characterized by repetitive stealing and has severe consequences for patients. Stigma, a lack of standardized therapy and a limited number of assessment tools hinder advances in treatment. This study provides preliminary data on the Portuguese-language version of the Kleptomania Symptom Assessment Scale (P-K-SAS) and preliminary data on an outpatient program. Methods Experts in the field analyzed an initial P-K-SAS version, p...

A Preliminary Rubric Design to Evaluate Mixed Methods Research

Science.gov (United States)

Burrows, Timothy J.

2013-01-01

With the increase in frequency of the use of mixed methods, both in research publications and in externally funded grants there are increasing calls for a set of standards to assess the quality of mixed methods research. The purpose of this mixed methods study was to conduct a multi-phase analysis to create a preliminary rubric to evaluate mixed…

Preliminary Monthly Climatological Summaries

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Preliminary Local Climatological Data, recorded since 1970 on Weather Burean Form 1030 and then National Weather Service Form F-6. The preliminary climate data pages...

Clinical assessment, staging, and epidemiology of chronic obstructive pulmonary disease exacerbations

DEFF Research Database (Denmark)

Vestbo, Jørgen

2006-01-01

Patients presenting with an exacerbation of chronic obstructive pulmonary disease (COPD) are initially assessed to ensure that a proper diagnosis has been made and that relevant differential diagnoses are excluded. Although guidelines provide indicators for use, very little systematic research has...... been done in initial assessment of COPD exacerbations. Next, the assessment should aim at stratifying patients for risk of poor outcome. For this, predictors of poor prognosis as well as knowledge of favorable treatments can be used. However, no formal and validated staging system exists today. Given...... the frequency and impact of COPD exacerbations, there seems to be a need for systematic research in this area....

Cystic fibrosis lung disease: genetic influences, microbial interactions, and radiological assessment

International Nuclear Information System (INIS)

Moskowitz, Samuel M.; Gibson, Ronald L.; Effmann, Eric L.

2005-01-01

Cystic fibrosis (CF) is a multiorgan disease caused by mutation of the CF transmembrane conductance regulator (CFTR) gene. Obstructive lung disease is the predominant cause of morbidity and mortality; thus, most efforts to improve outcomes are directed toward slowing or halting lung-disease progression. Current therapies, such as mucolytics, airway clearance techniques, bronchodilators, and antibiotics, aim to suppress airway inflammation and the processes that stimulate it, namely, retention and infection of mucus plaques at the airway surface. New approaches to therapy that aim to ameliorate specific CFTR mutations or mutational classes by restoring normal expression or function are being investigated. Because of its sensitivity in detecting changes associated with early airway obstruction and regional lung disease, high-resolution CT (HRCT) complements pulmonary function testing in defining disease natural history and measuring response to both conventional and experimental therapies. In this review, perspectives on the genetics and microbiology of CF provide a context for understanding the increasing importance of HRCT and other imaging techniques in assessing CF therapies. (orig.)

Preliminary assessment of the radiological protection aspects of disposal of high-level waste in geologic formations

International Nuclear Information System (INIS)

Hill, M.D; Grimwood, P.D.

1978-01-01

The purpose of this study is to carry out a preliminary assessment of the potential radiological consequences of disposing of vitrified high-level radioactive waste in geologic formations. The events which could lead to the release of radioactivity from a geologic repository are reviewed and ingress of ground-water is identified as the principal mechanism by which radioactivity may be transported back to the biosphere. A mathematical model of radionuclide migration with ground-water is used to predict possible rates of release of radioactivity into fresh water from a hypothetical repository containing all the high-level waste which may be generated in the UK up to the year 2000. The individual and collective doses which could be received as a result of man's use of contaminated fresh water are evaluated. The numerical results of the study depend very much on the assumptions made and cannot be used to draw any detailed conclusions. The main result is the identification of areas where further studies are required in order to carry out a full evaluation of this disposal option. (author)

The MacArthur Competence Assessment Tool-Fitness to Plead: a preliminary evaluation of a research instrument for assessing fitness to plead in England and Wales.

Science.gov (United States)

Akinkunmi, Akintunde A

2002-01-01

This study concerns the preliminary evaluation of an instrument, the MacArthur Competence Assessment Tool-Fitness to Plead (MacCAT-FP), for assessing competence to stand trial, according to the legal requirements in England and Wales. The purposes of the study were to ascertain whether the instrument can be administered practically to groups of prisoners, both those with mental illness and those without; to examine its internal consistency and interrater reliability; to determine whether it can distinguish between fit and unfit individuals, as judged by expert forensic psychiatrists; and to discover whether it is sensitive to changes over time. The instrument was administered to two groups of remanded prisoners: those transferred to psychiatric units for treatment and those without mental illness. In addition to the MacCAT-FP, scales measuring symptom severity and IQ were administered to all participants. Results suggest that the instrument is practical, with good internal consistency and interrater reliability. The correlation of scores with psychiatrists' opinions as to fitness was 0.77. Scores of unfit patients were significantly different from those of fit individuals. The instrument was able to detect significant differences in scores over time. It is suggested that once the instrument has been further validated for research purposes, it may be developed for clinical application.

Leaf reddening disease of pineapple in Ghana | Awuah | Ghana ...

African Journals Online (AJOL)

Mealybugs and ants are sometimes, but not always, associated with diseased plants. Nematodes of the genera Pratylenchus, Aphelenchus and. Helicotylenchus have been recovered, though infrequently, from roots and root zone soil of diseased plants. Based on these preliminary results and field observations, it is ...

Cognitive Task Analysis of Business Jet Pilots' Weather Flying Behaviors: Preliminary Results

Science.gov (United States)

Latorella, Kara; Pliske, Rebecca; Hutton, Robert; Chrenka, Jason

2001-01-01

This report presents preliminary findings from a cognitive task analysis (CTA) of business aviation piloting. Results describe challenging weather-related aviation decisions and the information and cues used to support these decisions. Further, these results demonstrate the role of expertise in business aviation decision-making in weather flying, and how weather information is acquired and assessed for reliability. The challenging weather scenarios and novice errors identified in the results provide the basis for experimental scenarios and dependent measures to be used in future flight simulation evaluations of candidate aviation weather information systems. Finally, we analyzed these preliminary results to recommend design and training interventions to improve business aviation decision-making with weather information. The primary objective of this report is to present these preliminary findings and to document the extended CTA methodology used to elicit and represent expert business aviator decision-making with weather information. These preliminary findings will be augmented with results from additional subjects using this methodology. A summary of the complete results, absent the detailed treatment of methodology provided in this report, will be documented in a separate publication.

Bladder symptoms assessed with overactive bladder questionnaire in Parkinson's disease.

Science.gov (United States)

Iacovelli, Elisa; Gilio, Francesca; Meco, Giuseppe; Fattapposta, Francesco; Vanacore, Nicola; Brusa, Livia; Giacomelli, Elena; Gabriele, Maria; Rubino, Alfonso; Locuratolo, Nicoletta; Iani, Cesare; Pichiorri, Floriana; Colosimo, Carlo; Carbone, Antonio; Palleschi, Giovanni; Inghilleri, Maurizio

2010-07-15

In Parkinson's disease (PD) the urinary dysfunction manifests primarily with symptoms of overactive bladder (OAB). The OAB questionnaire (OAB-q) is a measure designed to assess the impact of OAB symptoms on health-related quality of life. In this study, we quantified the urinary symptoms in a large cohort of PD patients by using the OAB-q short form. Possible correlations between the OAB-q and clinical features were tested. Three hundred and two PD patients were enrolled in the study. Correlations between the OAB-q and sex, age, Unified Parkinson's Disease Rating Scale part III (UPDRS-III), Hoehn-Yahr (H-Y) staging, disease duration, and treatment were analyzed. Data were compared with a large cohort of 303 age-matched healthy subjects. The OAB-q yielded significantly higher scores in PD patients than in healthy subjects. In the group of PD patients, all the variables tested were similar between men and women. Pearson's coefficient showed a significant correlation between mean age, disease duration, mean OAB-q scores, UPDRS-III scores, and H-Y staging. A multiple linear regression analysis showed that OAB-q values were significantly influenced by age and UPDRS-III. No statistical correlations were found between OAB-q scores and drug therapy or the equivalent levodopa dose, whilst the items relating to the nocturia symptoms were significantly associated with the equivalent levodopa dose. Our findings suggest that bladder dysfunction assessed by OAB-q mainly correlates with UPDRS-III scores for severity of motor impairment, possibly reflecting the known role of the decline in nigrostriatal dopaminergic function in bladder dysfunction associated with PD and patients' age. Our study also suggests that the OAB-q is a simple, easily administered test that can objectively evaluate bladder function in patients with PD.

Assessing Disordered Speech and Voice in Parkinson's Disease: A Telerehabilitation Application

Science.gov (United States)

Constantinescu, Gabriella; Theodoros, Deborah; Russell, Trevor; Ward, Elizabeth; Wilson, Stephen; Wootton, Richard

2010-01-01

Background: Patients with Parkinson's disease face numerous access barriers to speech pathology services for appropriate assessment and treatment. Telerehabilitation is a possible solution to this problem, whereby rehabilitation services may be delivered to the patient at a distance, via telecommunication and information technologies. A number of…

A preliminary assessment of polymer-modified cements for use in immobilisation of intermediate level radioactive waste

International Nuclear Information System (INIS)

Burnay, S.G.; Dyson, J.R.

1982-11-01

A range of polymer-modified cements has been examined as candidate materials for the immobilisation of intermediate level radioactive waste. The waste streams studied were inactive simulates of real wastes and included ion-exchange resins, Magnox debris and dilute sludges. Preliminary experiments on the compatibility of the polymer-cement-waste combinations have been carried out and measurements of flexural strength before and after #betta#-irradiation to 10 9 rad and water immersion have been made. Soxhlet leach tests have been used to compare the leach rates of the different materials. From the results of these preliminary experiments, a limited number of polymer-modified cements have been suggested as suitable for more detailed study. (author)

Comparison of Disease Activity Score in 28 joints with ESR (DAS28, Clinical Disease Activity Index (CDAI, Health Assessment Questionnaire Disability Index (HAQ-DI & Routine Assessment of Patient Index Data with 3 measures (RAPID3 for assessing disease activity in patients with rheumatoid arthritis at initial presentation

Directory of Open Access Journals (Sweden)

B Siddhartha Kumar

2017-01-01

Interpretation & conclusions: In adult patients with RA, in the setting where illiteracy is high, CDAI emerged as the preferred choice for rapid assessment of severity of disease at the time of initial presentation.

Hazard analysis of critical control points assessment as a tool to respond to emerging infectious disease outbreaks.

Directory of Open Access Journals (Sweden)

Kelly L Edmunds

Full Text Available Highly pathogenic avian influenza virus (HPAI strain H5N1 has had direct and indirect economic impacts arising from direct mortality and control programmes in over 50 countries reporting poultry outbreaks. HPAI H5N1 is now reported as the most widespread and expensive zoonotic disease recorded and continues to pose a global health threat. The aim of this research was to assess the potential of utilising Hazard Analysis of Critical Control Points (HACCP assessments in providing a framework for a rapid response to emerging infectious disease outbreaks. This novel approach applies a scientific process, widely used in food production systems, to assess risks related to a specific emerging health threat within a known zoonotic disease hotspot. We conducted a HACCP assessment for HPAI viruses within Vietnam's domestic poultry trade and relate our findings to the existing literature. Our HACCP assessment identified poultry flock isolation, transportation, slaughter, preparation and consumption as critical control points for Vietnam's domestic poultry trade. Introduction of the preventative measures highlighted through this HACCP evaluation would reduce the risks posed by HPAI viruses and pressure on the national economy. We conclude that this HACCP assessment provides compelling evidence for the future potential that HACCP analyses could play in initiating a rapid response to emerging infectious diseases.

Human Environmental Disease Network: A computational model to assess toxicology of contaminants.

Science.gov (United States)

Taboureau, Olivier; Audouze, Karine

2017-01-01

During the past decades, many epidemiological, toxicological and biological studies have been performed to assess the role of environmental chemicals as potential toxicants associated with diverse human disorders. However, the relationships between diseases based on chemical exposure rarely have been studied by computational biology. We developed a human environmental disease network (EDN) to explore and suggest novel disease-disease and chemical-disease relationships. The presented scored EDN model is built upon the integration of systems biology and chemical toxicology using information on chemical contaminants and their disease relationships reported in the TDDB database. The resulting human EDN takes into consideration the level of evidence of the toxicant-disease relationships, allowing inclusion of some degrees of significance in the disease-disease associations. Such a network can be used to identify uncharacterized connections between diseases. Examples are discussed for type 2 diabetes (T2D). Additionally, this computational model allows confirmation of already known links between chemicals and diseases (e.g., between bisphenol A and behavioral disorders) and also reveals unexpected associations between chemicals and diseases (e.g., between chlordane and olfactory alteration), thus predicting which chemicals may be risk factors to human health. The proposed human EDN model allows exploration of common biological mechanisms of diseases associated with chemical exposure, helping us to gain insight into disease etiology and comorbidity. This computational approach is an alternative to animal testing supporting the 3R concept.

Safety performance of preliminary KALIMER conceptual design

Energy Technology Data Exchange (ETDEWEB)

Hahn Dohee; Kim Kyoungdoo; Kwon Youngmin; Chang Wonpyo; Suk Soodong [Korea atomic Energy Resarch Inst., Taejon (Korea)

1999-07-01

The Korea Atomic Energy Research Institute (KAERI) is developing KALIMER (Korea Advanced Liquid Metal Reactor), which is a sodium cooled, 150 MWe pool-type reactor. The safety design of KALIMER emphasizes accident prevention by using passive processes, which can be accomplished by the safety design objectives including the utilization of inherent safety features. In order to assess the effectiveness of the inherent safety features in achieving the safety design objectives, a preliminary evaluation of ATWS performance for the KALIMER design has been performed with SSC-K code, which is a modified version of SSC-L code. KAERI's modification of the code includes development of reactivity feedback models for the core and a pool model for KALIMER reactor vessel. This paper describes the models for control rod driveline expansion, gas expansion module and the thermal hydraulic model for reactor pool and the results of preliminary analyses for unprotected loss of flow and loss o heat sink. (author)

Safety performance of preliminary KALIMER conceptual design

International Nuclear Information System (INIS)

Hahn Dohee; Kim Kyoungdoo; Kwon Youngmin; Chang Wonpyo; Suk Soodong

1999-01-01

The Korea Atomic Energy Research Institute (KAERI) is developing KALIMER (Korea Advanced Liquid Metal Reactor), which is a sodium cooled, 150 MWe pool-type reactor. The safety design of KALIMER emphasizes accident prevention by using passive processes, which can be accomplished by the safety design objectives including the utilization of inherent safety features. In order to assess the effectiveness of the inherent safety features in achieving the safety design objectives, a preliminary evaluation of ATWS performance for the KALIMER design has been performed with SSC-K code, which is a modified version of SSC-L code. KAERI's modification of the code includes development of reactivity feedback models for the core and a pool model for KALIMER reactor vessel. This paper describes the models for control rod driveline expansion, gas expansion module and the thermal hydraulic model for reactor pool and the results of preliminary analyses for unprotected loss of flow and loss o heat sink. (author)

Assessment of inflammatory activity in Crohn's disease by means of dynamic contrast-enhanced MRI.

Science.gov (United States)

Pupillo, V A; Di Cesare, E; Frieri, G; Limbucci, N; Tanga, M; Masciocchi, C

2007-09-01

Our aim was to perform a dynamic study of contrast enhancement of the intestinal wall in patients with Crohn's disease to quantitatively assess local inflammatory activity. We studied a population of 50 patients with histologically proven Crohn's disease. Magnetic resonance imaging (MRI) was performed using a 1.5-T magnet with a phased-array coil and acquisition of T2-weighted single-shot fast spin echo (SSFSE) half Fourier sequences before intravenous administration of gadolinium, and T1-weighted fast spoiled gradient (FSPGR) fat-saturated sequences before and after contrast administration. Before the examination, patents received oral polyethylene glycol (PEG) (1,000 ml for adults; 10 ml/Kg of body weight for children). Regions of interest (ROI) were placed on the normal and diseased intestinal wall to assess signal intensity and rate of increase in contrast enhancement over time. Data were compared with the Crohn's Disease Activity Index (CDAI). The diseased bowel wall showed early and intense uptake of contrast that increases over time until a plateau is reached. In patients in the remission phase after treatment, signal intensity was only slightly higher in diseased bowel loops than in healthy loops. There was a significant correlation between the peak of contrast uptake and CDAI. Dynamic MRI is a good technique for quantifying local inflammatory activity of bowel wall in patients with Crohn's disease.

Preliminary disposal limits, plume interaction factors, and final disposal limits

Energy Technology Data Exchange (ETDEWEB)

Flach, G. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

2018-01-11

In the 2008 E-Area Performance Assessment (PA), each final disposal limit was constructed as the product of a preliminary disposal limit and a plume interaction factor. The following mathematical development demonstrates that performance objectives are generally expected to be satisfied with high confidence under practical PA scenarios using this method. However, radionuclides that experience significant decay between a disposal unit and the 100-meter boundary, such as H-3 and Sr-90, can challenge performance objectives, depending on the disposed-of waste composition, facility geometry, and the significance of the plume interaction factor. Pros and cons of analyzing single disposal units or multiple disposal units as a group in the preliminary disposal limits analysis are also identified.

Measurement instruments to assess posture, gait, and balance in Parkinson's disease: Critique and recommendations

NARCIS (Netherlands)

Bloem, B.R.; Marinus, J.; Almeida, Q.; Dibble, L.; Nieuwboer, A.; Post, B.; Ruzicka, E.; Goetz, C.; Stebbins, G.; Martinez-Martin, P.; Schrag, A.

2016-01-01

BACKGROUND: Disorders of posture, gait, and balance in Parkinson's disease (PD) are common and debilitating. This MDS-commissioned task force assessed clinimetric properties of existing rating scales, questionnaires, and timed tests that assess these features in PD. METHODS: A literature review was

Preliminary assessment of potential underground stability (wedge and spalling) at Forsmark, Simpevarp and Laxemar sites

Energy Technology Data Exchange (ETDEWEB)

Martin, Derek [Univ. of Alberta, Edmonton (Canada). Geotechnical Engineering

2005-12-15

In SKB's Underground Design Premises the objective in the early design phase is to estimate if there is sufficient space for the repository at a site. One of the conditions that could limit the space available is stability of the underground openings, i.e., deposition tunnels and deposition boreholes. The purpose of this report is to provide a preliminary assessment of the potential for wedge instability and spalling that may be encountered at the Forsmark, Simpevarp and Laxemar sites based on information from the site investigations program up to July 30, 2004. The rock mass spalling strength was defined using the in-situ results from SKB's Aespoe Pillar Stability Experiment and AECL's Mine-by Experiment. These experiments suggest that the rock mass spalling strength for crystalline rocks can be estimated as 0.57 of the mean laboratory uniaxial compressive strength. A probability-based methodology utilizing this in-situ rock mass spalling strength has been developed for assessing the risk for spalling in a repository at the Forsmark, Simpevarp and Laxemar sites. The in-situ stresses and the uniaxial compressive strength data from these sites were used as the bases for the analyses. Preliminary findings from all sites suggest that, generally, the risk for spalling increases as the depth of the repository increases, simply because the stress magnitudes increase with depth. The depth at which the risk for spalling is significant, depends on the individual sites which are discussed below. The greatest uncertainty in the spalling analyses for Forsmark is related to the uncertainty in the horizontal stress magnitudes and associated stress gradients with depth. The confidence in these analyses can only be increased by increasing the confidence in the stress and geology model for the site. From the analyses completed it appears that spalling in the deposition tunnels can be controlled by orienting the tunnels approximately parallel to the maximum horizontal

Preliminary Hazards Analysis Plasma Hearth Process

International Nuclear Information System (INIS)

Aycock, M.; Coordes, D.; Russell, J.; TenBrook, W.; Yimbo, P.

1993-11-01

This Preliminary Hazards Analysis (PHA) for the Plasma Hearth Process (PHP) follows the requirements of United States Department of Energy (DOE) Order 5480.23 (DOE, 1992a), DOE Order 5480.21 (DOE, 1991d), DOE Order 5480.22 (DOE, 1992c), DOE Order 5481.1B (DOE, 1986), and the guidance provided in DOE Standards DOE-STD-1027-92 (DOE, 1992b). Consideration is given to ft proposed regulations published as 10 CFR 830 (DOE, 1993) and DOE Safety Guide SG 830.110 (DOE, 1992b). The purpose of performing a PRA is to establish an initial hazard categorization for a DOE nuclear facility and to identify those processes and structures which may have an impact on or be important to safety. The PHA is typically performed during and provides input to project conceptual design. The PRA then is followed by a Preliminary Safety Analysis Report (PSAR) performed during Title I and II design. This PSAR then leads to performance of the Final Safety Analysis Report performed during construction, testing, and acceptance and completed before routine operation. Radiological assessments indicate that a PHP facility, depending on the radioactive material inventory, may be an exempt, Category 3, or Category 2 facility. The calculated impacts would result in no significant impact to offsite personnel or the environment. Hazardous material assessments indicate that a PHP facility will be a Low Hazard facility having no significant impacts either onsite or offsite to personnel and the environment

Radionuclide assessment of Gaucher's disease

International Nuclear Information System (INIS)

Cheng, T.H.; Holman, B.L.

1978-01-01

Gaucher's disease involves multiple organs and may present with variable severity. The scintigraphic appearance of the reticuloendothelial system and bone are described in three patients with Gaucher's disease. Scintigraphic abnormalities reflected the severity of organ involvement and correlated well with the patients' clinical status. Scintigraphy appears useful for the evaluation and followup of patients with Gaucher's disease

Ad hoc method for the assessment on listing and categorisation of animal diseases within the framework of the Animal Health Law

DEFF Research Database (Denmark)

More, Simon J.; Bøtner, Anette; Butterworth, Andrew

2017-01-01

compiled by disease scientists. A mapping was developed to identify which parameters from Article 7 were needed to inform each Article 5, 8 and 9 criterion. Specifically, for Articles 5 and 9 criteria, a categorical assessment was performed, by applying an expert judgement procedure, based on the mapped......The European Commission has requested EFSA to assess animal diseases according to the criteria as laid down in Articles 5, 7, 8 and Annex IV for the purpose of categorisation of diseases in accordance with Article 9 of the Regulation (EU) No 2016/429 (Animal Health Law). This scientific opinion...... addresses the ad hoc method developed for assessing any animal disease for the listing and categorisation of diseases within the Animal Health Law (AHL) framework. The assessment of individual diseases is addressed in distinct scientific opinions that are published separately. The assessment of Articles 5...

Whole-Body MRI versus PET in assessment of multiple myeloma disease activity.

LENUS (Irish Health Repository)

Shortt, Conor P

2009-04-01

The purpose of this study was to compare FDG PET; whole-body MRI; and the reference standard, bone marrow aspiration and biopsy, to determine the best imaging technique for assessment of disease activity in multiple myeloma.

Serum Immunoglobulin Free Light Chain Assessment in IgG4-Related Disease

Directory of Open Access Journals (Sweden)

Aurélie Grados

2013-01-01

Full Text Available Immunoglobulin free light chains are produced in excess during normal antibody synthesis. Their evaluation is commonly used in case of a monoclonal gammopathy. In polyclonal hypergammaglobulinemia related to the Sjögren syndrome or systemic lupus, erythematosus serum free light chain levels are increased and could correlate with disease activity. We show here that the κ ( and λ ( free light chains and the κ : λ ratio ( are increased in sixteen patients with IgG4-related disease when compared to healthy controls. The increase of κ and λ free light chains probably reflects the marked polyclonal B cell activation of the disease. We could not assess in this small cohort of patients a significative correlation of serum free light chain levels and disease activity or extension.

The Alzheimer's Disease Knowledge Scale: Development and Psychometric Properties

Science.gov (United States)

Carpenter, Brian D.; Balsis, Steve; Otilingam, Poorni G.; Hanson, Priya K.; Gatz, Margaret

2009-01-01

Purpose: This study provides preliminary evidence for the acceptability, reliability, and validity of the new Alzheimer's Disease Knowledge Scale (ADKS), a content and psychometric update to the Alzheimer's Disease Knowledge Test. Design and Methods: Traditional scale development methods were used to generate items and evaluate their psychometric…

Exponential Decay Nonlinear Regression Analysis of Patient Survival Curves: Preliminary Assessment in Non-Small Cell Lung Cancer

Science.gov (United States)

Stewart, David J.; Behrens, Carmen; Roth, Jack; Wistuba, Ignacio I.

2010-01-01

Background For processes that follow first order kinetics, exponential decay nonlinear regression analysis (EDNRA) may delineate curve characteristics and suggest processes affecting curve shape. We conducted a preliminary feasibility assessment of EDNRA of patient survival curves. Methods EDNRA was performed on Kaplan-Meier overall survival (OS) and time-to-relapse (TTR) curves for 323 patients with resected NSCLC and on OS and progression-free survival (PFS) curves from selected publications. Results and Conclusions In our resected patients, TTR curves were triphasic with a “cured” fraction of 60.7% (half-life [t1/2] >100,000 months), a rapidly-relapsing group (7.4%, t1/2=5.9 months) and a slowly-relapsing group (31.9%, t1/2=23.6 months). OS was uniphasic (t1/2=74.3 months), suggesting an impact of co-morbidities; hence, tumor molecular characteristics would more likely predict TTR than OS. Of 172 published curves analyzed, 72 (42%) were uniphasic, 92 (53%) were biphasic, 8 (5%) were triphasic. With first-line chemotherapy in advanced NSCLC, 87.5% of curves from 2-3 drug regimens were uniphasic vs only 20% of those with best supportive care or 1 drug (p<0.001). 54% of curves from 2-3 drug regimens had convex rapid-decay phases vs 0% with fewer agents (p<0.001). Curve convexities suggest that discontinuing chemotherapy after 3-6 cycles “synchronizes” patient progression and death. With postoperative adjuvant chemotherapy, the PFS rapid-decay phase accounted for a smaller proportion of the population than in controls (p=0.02) with no significant difference in rapid-decay t1/2, suggesting adjuvant chemotherapy may move a subpopulation of patients with sensitive tumors from the relapsing group to the cured group, with minimal impact on time to relapse for a larger group of patients with resistant tumors. In untreated patients, the proportion of patients in the rapid-decay phase increased (p=0.04) while rapid-decay t1/2 decreased (p=0.0004) with increasing