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Sample records for preliminary core sets

  1. A Preliminary Core Domain Set for Clinical Trials of Shoulder Disorders: A Report from the OMERACT 2016 Shoulder Core Outcome Set Special Interest Group.

    Science.gov (United States)

    Buchbinder, Rachelle; Page, Matthew J; Huang, Hsiaomin; Verhagen, Arianne P; Beaton, Dorcas; Kopkow, Christian; Lenza, Mario; Jain, Nitin B; Richards, Bethan; Richards, Pamela; Voshaar, Marieke; van der Windt, Danielle; Gagnier, Joel J

    2017-01-15

    The Outcome Measures in Rheumatology (OMERACT) Shoulder Core Outcome Set Special Interest Group (SIG) was established to develop a core outcome set (COS) for clinical trials of shoulder disorders. In preparation for OMERACT 2016, we systematically examined all outcome domains and measurement instruments reported in 409 randomized trials of interventions for shoulder disorders published between 1954 and 2015. Informed by these data, we conducted an international Delphi consensus study including shoulder trial experts, clinicians, and patients to identify key domains that should be included in a shoulder disorder COS. Findings were discussed at a stakeholder premeeting of OMERACT. At OMERACT 2016, we sought consensus on a preliminary core domain set and input into next steps. There were 13 and 15 participants at the premeeting and the OMERACT 2016 SIG meeting, respectively (9 attended both meetings). Consensus was reached on a preliminary core domain set consisting of an inner core of 4 domains: pain, physical function/activity, global perceived effect, and adverse events including death. A middle core consisted of 3 domains: emotional well-being, sleep, and participation (recreation and work). An outer core of research required to inform the final COS was also formulated. Our next steps are to (1) analyze whether participation (recreation and work) should be in the inner core, (2) conduct a third Delphi round to finalize definitions and wording of domains and reach final endorsement for the domains, and (3) determine which instruments fulfill the OMERACT criteria for measuring each domain.

  2. ICF Core Sets for stroke

    National Research Council Canada - National Science Library

    Szilvia Geyh; Alarcos Cieza; Jan Schouten; Hugh Dickson; Peter Frommelt; Zaliha Omar; Nenad Kostanjsek; Haim Ring; Gerold Stucki

    2004-01-01

    Objective: To report on the results of the consensus process integrating evidence from preliminary studies to develop the first version of the Comprehensive ICF Core Set and the Brief ICF Core Set for stroke. Methods...

  3. Feasibility of Applying the Extended ICF Core Set for Stroke to Clinical Settings in Rehabilitation: A Preliminary Study

    Science.gov (United States)

    Han, Kyu Yong; Kim, Hyo Jong

    2015-01-01

    Objective To evaluate the potential feasibility of application of the extended International Classification of Functioning, Disability and Health (ICF) Core Set for stroke. Methods We retrospectively reviewed the medical records of 40 stroke outpatients (>6 months after onset) admitted to the Department of Rehabilitation Medicine for comprehensive rehabilitation. Clinical information of the patients were respectively evaluated to link to the 166 second-level categories of the extended ICF Core Set for stroke. Results Clinical information could be linked to 111 different ICF categories, 58 categories of the body functions component, eight categories of the body structures component, 38 categories of the activities and participation component, and seven categories of the environmental factors component. Conclusion The body functions component might be feasible for application of the extended ICF Core Set for stroke to clinical settings. The activities and participation component and environmental factors component may not be directly applied to clinical settings without additional evaluation tools including interview and questionnaire. PMID:25750873

  4. Developing comprehensive and Brief ICF core sets for morbid obesity for disability assessment in Taiwan: a preliminary study.

    Science.gov (United States)

    Lin, Y-N; Chang, K-H; Lin, C-Y; Hsu, M-I; Chen, H-C; Chen, H-H; Liou, T-H

    2014-04-01

    The International Classification of Functioning, Disability, and Health (ICF) provides a framework for measuring functioning and disability based on a biopsychosocial model. The aim of this study was to develop comprehensive and brief ICF core sets for morbid obesity for disability assessment in Taiwan. Observational Other Twenty-nine multidisciplinary experts of ICF METHODS: The questionnaire contained 112 obesity-relevant and second-level ICF categories. Using a 5-point Likert scale, the participants rated the significance of the effects of each category on the heath status of people with obesity. Correlation between an individual's score and the average score of the group indicated consensus. The categories were selected for the comprehensive core set for obesity if more than 50% of the experts rated them as "important" in the third round of the Delphi exercise, and for the brief core set if more than 80% of the experts rated them "very important." Twenty-nine experts participated in the study. These included 18 physicians, 4 dieticians, 3 physical therapists, 2 nurses, and 2 ICF experts. The comprehensive core set for morbid obesity contained 61 categories. Of these, 26 categories were from the component body function, 8 were from body structure, 18 were from activities and participation, and 9 were from environmental factors. The brief core set for obesity disability contained 29 categories. Of these, 19 categories were from the component body function, 3 were from body structure, 6 were from activities and participation, and one was from environmental factors. The comprehensive and brief ICF core sets provide comprehensive information on the health effects of morbid obesity and concise information for clinical practice. Comprehensive and brief core sets were created after three rounds of Delphi technique. Further validation study of these core sets by applying to patients with morbid obesity is needed. The comprehensive ICF core set for morbid obesity

  5. Analytical Chemistry Core Capability Assessment - Preliminary Report

    Energy Technology Data Exchange (ETDEWEB)

    Barr, Mary E. [Los Alamos National Laboratory; Farish, Thomas J. [Los Alamos National Laboratory

    2012-05-16

    The concept of 'core capability' can be nebulous one. Even at a fairly specific level, where core capability equals maintaining essential services, it is highly dependent upon the perspective of the requestor. Samples are submitted to analytical services because the requesters do not have the capability to conduct adequate analyses themselves. Some requests are for general chemical information in support of R and D, process control, or process improvement. Many analyses, however, are part of a product certification package and must comply with higher-level customer quality assurance requirements. So which services are essential to that customer - just those for product certification? Does the customer also (indirectly) need services that support process control and improvement? And what is the timeframe? Capability is often expressed in terms of the currently utilized procedures, and most programmatic customers can only plan a few years out, at best. But should core capability consider the long term where new technologies, aging facilities, and personnel replacements must be considered? These questions, and a multitude of others, explain why attempts to gain long-term consensus on the definition of core capability have consistently failed. This preliminary report will not try to define core capability for any specific program or set of programs. Instead, it will try to address the underlying concerns that drive the desire to determine core capability. Essentially, programmatic customers want to be able to call upon analytical chemistry services to provide all the assays they need, and they don't want to pay for analytical chemistry services they don't currently use (or use infrequently). This report will focus on explaining how the current analytical capabilities and methods evolved to serve a variety of needs with a focus on why some analytes have multiple analytical techniques, and what determines the infrastructure for these analyses. This

  6. EEA core set of indicators. Guide

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    This guide provides information on the quality of the 37 indicators in the EEA core set. Its primary role is to support improved implementation of the core set in the EEA, European topic centres and the European environment information and observation network (Eionet). In parallel, it is aimed at helping users outside the EEA/Eionet system make best use of the indicators in their own work. It is hoped that the guide will promote cooperation on improving indicator methodologies and data quality as part of the wider process to streamline and improve environmental reporting in the European Union and beyond. (au)

  7. ABSTRACTS Preliminary Study of Strategic Inner Cores

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    When a strategic entity attempts to make a dicision, first the project must be m accoroance wlm its strategic framework as well as make the strategic inner cores prominent. The existing theories of development strategy indicate that the formation of the framework can be divided into the following parts: inside and outside environments, purpose, goal, key points, and countermeasures. The strategic inner cores that put forward by this paper is the intensification and advancement for the theory of strategic framework, strategic orientation, strategic vision and main line are inciuded. Appearance of these ideas have improved the theory and enhanced strategic practice.

  8. After Common Core, States Set Rigorous Standards

    Science.gov (United States)

    Peterson, Paul E.; Barrows, Samuel; Gift, Thomas

    2016-01-01

    In spite of Tea Party criticism, union skepticism, and anti-testing outcries, the campaign to implement Common Core State Standards (otherwise known as Common Core) has achieved phenomenal success in statehouses across the country. Since 2011, 45 states have raised their standards for student proficiency in reading and math, with the greatest…

  9. Preliminary Core Analysis of a Micro Modular Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Jo, Chang Keun; Chang, Jongwa [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Venneri, Francesco [Ultra Safe Nuclear Corporation, Los Alamos (United States); Hawari, Ayman [NC State Univ., Raleigh (United States)

    2014-05-15

    The Micro Modular Reactor (MMR) will be 'melt-down proof'(MDP) under all circumstances, including the complete loss of coolant, and will be easily transportable and retrievable, and suitable for use with very little site preparation and Balance of Plant (BOP) requirements for a variety of applications, from power generation and process heat applications in remote areas to grid-unattached locations, including ship propulsion. The Micro Modular Reactor design proposed in this paper has 3 meter diameter core (2 meter active core) which is suitable for 'factory manufactured' and has few tens year of service life for remote deployment. We confirmed the feasibility of long term service life by a preliminary neutronic analysis in terms of the excess reactivity, the temperature feedback coefficient, and the control margins. We are able to achieve a reasonably long core life time of 5 ∼ 10 years under typical thermal hydraulic condition of a helium cooled reactor. However, on a situation where longer service period and safety is important, we can reduce the power density to the level of typical pebble bed reactor. In this case we can design 10 MWt MMR with core diameter for 10 ∼ 40 years core life time without much loss in the economics. Several burnable poisons are studied and it is found that erbia mixed in the compact matrix seems reasonably good poison. The temperature feedback coefficients were remaining negative during lifetime. Drum type control rods at reflector region and few control rods inside core region are sufficient to control the reactivity during operation and to achieve safe cold shutdown state.

  10. Core set approach to reduce uncertainty of gene trees

    Directory of Open Access Journals (Sweden)

    Okuhara Yoshiyasu

    2006-05-01

    Full Text Available Abstract Background A genealogy based on gene sequences within a species plays an essential role in the estimation of the character, structure, and evolutionary history of that species. Because intraspecific sequences are more closely related than interspecific ones, detailed information on the evolutionary process may be available by determining all the node sequences of trees and provide insight into functional constraints and adaptations. However, strong evolutionary correlations on a few lineages make this determination difficult as a whole, and the maximum parsimony (MP method frequently allows a number of topologies with a same total branching length. Results Kitazoe et al. developed multidimensional vector-space representation of phylogeny. It converts additivity of evolutionary distances to orthogonality among the vectors expressing branches, and provides a unified index to measure deviations from the orthogoality. In this paper, this index is used to detect and exclude sequences with large deviations from orthogonality, and then selects a maximum subset ("core set" of sequences for which MP generates a single solution. Once the core set tree is formed whose all the node sequences are given, the excluded sequences are found to have basically two phylogenetic positions on this tree, respectively. Fortunately, since multiple substitutions are rare in intra-species sequences, the variance of nucleotide transitions is confined to a small range. By applying the core set approach to 38 partial env sequences of HIV-1 in a single patient and also 198 mitochondrial COI and COII DNA sequences of Anopheles dirus, we demonstrate how consistently this approach constructs the tree. Conclusion In the HIV dataset, we confirmed that the obtained core set tree is the unique maximum set for which MP proposes a single tree. In the mosquito data set, the fluctuation of nucleotide transitions caused by the sequences excluded from the core set was very small

  11. Updating the Psoriatic Arthritis (PsA) Core Domain Set

    DEFF Research Database (Denmark)

    Orbai, Ana-Maria; de Wit, Maarten; Mease, Philip J

    2017-01-01

    OBJECTIVE: To include the patient perspective in accordance with the Outcome Measures in Rheumatology (OMERACT) Filter 2.0 in the updated Psoriatic Arthritis (PsA) Core Domain Set for randomized controlled trials (RCT) and longitudinal observational studies (LOS). METHODS: At OMERACT 2016, research...

  12. Engaging Stakeholders and Promoting Uptake of OMERACT Core Outcome Instrument Sets.

    Science.gov (United States)

    Tunis, Sean R; Maxwell, Lara J; Graham, Ian D; Shea, Beverley J; Beaton, Dorcas E; Bingham, Clifton O; Brooks, Peter; Conaghan, Philip G; D'Agostino, Maria Antonietta; de Wit, Maarten P; Gossec, Laure; March, Lyn M; Simon, Lee S; Singh, Jasvinder A; Strand, Vibeke; Wells, George A; Tugwell, Peter

    2017-08-01

    While there has been substantial progress in the development of core outcomes sets, the degree to which these are used by researchers is variable. We convened a special workshop on knowledge translation at the Outcome Measures in Rheumatology (OMERACT) 2016 with 2 main goals. The first focused on the development of a formal knowledge translation framework and the second on promoting uptake of recommended core outcome domain and instrument sets. We invited all 189 OMERACT 2016 attendees to the workshop; 86 attended, representing patient research partners (n = 15), healthcare providers/clinician researchers (n = 52), industry (n = 4), regulatory agencies (n = 4), and OMERACT fellows (n = 11). Participants were given an introduction to knowledge translation and were asked to propose and discuss recommendations for the OMERACT community to (1) strengthen stakeholder involvement in the core outcome instrument set development process, and (2) promote uptake of core outcome sets with a specific focus on the potential role of post-regulatory decision makers. We developed the novel "OMERACT integrated knowledge translation" framework, which formalizes OMERACT's knowledge translation strategies. We produced strategies to improve stakeholder engagement throughout the process of core outcome set development and created a list of creative and innovative ways to promote the uptake of OMERACT's core outcome sets. The guidance provided in this paper is preliminary and is based on the views of the participants. Future work will engage OMERACT groups, "post-regulatory decision makers," and a broad range of different stakeholders to identify and evaluate the most useful methods and processes, and to revise guidance accordingly.

  13. Development of a Provisional Core Domain Set for Polymyalgia Rheumatica : Report from the OMERACT 12 Polymyalgia Rheumatica Working Group

    NARCIS (Netherlands)

    Helliwell, Toby; Brouwer, Elisabeth; Pease, Colin T.; Hughes, Rodney; Hill, Catherine L.; Neill, Lorna M.; Halls, Serena; Simon, Lee S.; Mallen, Christian D.; Boers, Maarten; Kirwan, John R.; Mackie, Sarah L.

    2016-01-01

    Objective. The Outcome Measures in Rheumatology (OMERACT) polymyalgia rheumatica (PMR) working group aims to develop a core set of outcome measures to be used in clinical trials for PMR. Previous reports from OMERACT 11 included a qualitative study of the patient experience and a preliminary literat

  14. The Mount Logan (Yukon) Ice Cores: Preliminary Results

    Science.gov (United States)

    Fisher, D. A.

    2004-05-01

    Three ice cores were taken at different elevations on or near My Logan in the years 2001 and 2002. The summit core (PRCol) comes from the summit plateau ( 5340 masl, length 187 m to bedrock, mean temperature -29 C ) and was done by the Geological Survey of Canada. The NIPR group cored 210m on the flanks of the mountain at King Col (4200 masl mean temperature -16C) and the UNH group cored 20 km from the mountain at Eclipse "Dome" (3015 masl,length 345 m mean temperature -5C) . The three cores were done cooperatively by GSC, NIPR and UNH and cover nominally 30 ka, 1 ka and 2ka respectively . Located very close to the Gulf of Alaska these core records are thought to reflect the climate history of the Pacific Ocean and having three widely spaced elevations, the sites "see" different distances to different sources. The lowest site (Eclipse) has excellent seasonals but a very muted δ 18O history with no obvious little ice age, whereas the most recent 1ka of the PRCol summit sites contains two very large and sudden δ 18O and d (deuterium excess) shifts at 1850 AD and ~ 800 AD. The δ 18O shifts which happen from one year to the next are about 4 o/oo . The summit site (PRCol) δ 18O response is "backwards", ie the Little Ice Age δ 18O values are 4 o/oo more positive than recent ones. The PRCol δ 18O and d suggest that the source water can either be ëlocalí (Gulf of Alaska) or very distant (tropics) . The Eclipse site seems only to get the local water . A massive dust storm originating in central Asia (Gobi) in April 2001 dumped a visible layer all over the St Elias Mountains and this layer was sampled, to provide a calibration "Asian dust event". The satellite and isotoic signatures both agreed that Gobi was the source. The PRCol record covers the Holocene and well back into the ice age. The transition is defined by a sudden ECM shift on the flanks of a more gradual O18 shift. Acknowledgements. Logan consortium consists of : Geological Survey of Canada : Jocelyne

  15. Establishing a core domain set to measure rheumatoid arthritis flares

    DEFF Research Database (Denmark)

    Bykerk, Vivian P; Lie, Elisabeth; Bartlett, Susan J;

    2014-01-01

    agenda for OMERACT 12. CONCLUSION: At OMERACT 11, a core domain set to measure RA flare was ratified and endorsed by attendees. Domain validation aligning with Filter 2.0 is ongoing in new randomized controlled clinical trials and longitudinal observational studies using existing and new instruments......OBJECTIVE: The OMERACT Rheumatoid Arthritis (RA) Flare Group (FG) is developing a data-driven, patient-inclusive, consensus-based RA flare definition for use in clinical trials, longterm observational studies, and clinical practice. At OMERACT 11, we sought endorsement of a proposed core domain set....... At OMERACT 11, breakout groups discussed key domains and instruments to measure them, and proposed a research agenda. Patients were active research partners in all focus groups and domain identification activities. Processes for domain selection and patient partner involvement were case studies for OMERACT...

  16. On the bargaining set, kernel and core of superadditive games

    OpenAIRE

    TamÂs Solymosi

    1999-01-01

    We prove that for superadditive games a necessary and sufficient condition for the bargaining set to coincide with the core is that the monotonic cover of the excess game induced by a payoff be balanced for each imputation in the bargaining set. We present some new results obtained by verifying this condition for specific classes of games. For N-zero-monotonic games we show that the same condition required at each kernel element is also necessary and sufficient for the kernel to be contained ...

  17. On the Set of Grouplikes of a Coring

    Institute of Scientific and Technical Information of China (English)

    L.EL KAOUTIT; J. G(O)MEZ-TORRECILLAS

    2012-01-01

    We focus our attention to the set Gr((C)) of grouplike elements of a coring (C) over a ring A.We do some observations on the actions of the groups U(A) and Aut((C)) of units of A and of automorphisms of corings of (C),respectively,on Gr((C)),and on the subset Gal((C)) of all Galois grouplike elements.Among them,we give conditions on (C) under which Gal((C)) is a group,in such a way that there is an exact sequence of groups {1} → U(Ag) → U(A) → Gal((C)) → {1},where A(g) is the subalgebra of coinvariants for some g ∈ Gal((C)).

  18. The feasibility and validity of the comprehensive ICF core set for stroke in Chinese clinical settings.

    Science.gov (United States)

    Wang, Pu; Li, Huagang; Guo, Yi; Xie, Yuxiao; Ge, Ruidong; Qiu, Zhuoying

    2014-02-01

    To inspect the feasibility and content validity of the comprehensive International Classification of Functioning, Disability and Health (ICF) core set for stroke by describing relevant aspects of functioning, disability and environmental factors affected in Chinese patients post stroke. Multicentre, cross-sectional study. Department of rehabilitation medicine. The content validity was evaluated using frequency and percentage of 208 patients with a mean age of 60 years post stroke in China. Aspects of body function and structure, activity and participation, and environmental factors in the comprehensive ICF core set for stroke. Six ICF categories of body function were identified as a problem in over 90% (n = 187) of the patients (functions of the cardiovascular system and neuromusculoskeletal and movement-related functions). Impairments of brain, upper and lower extremity were identified as a problem in over 50% (n = 104) of the patients. Four ICF categories of activities and participation were documented as a problem in 100% (n = 208) of the patients (domestic and civic life). In environmental factors, nine ICF categories were documented as barriers by more than 10% (n = 20) and fewer than 50% (n = 104) of the patients (products and technology, physical geography, societal attitudes, services, systems and polices). Six ICF categories were identified as facilitators in over 90% (n = 187) of the patients (support and relationships and attitudes). The findings suggest that it is feasible to apply the comprehensive ICF core set for stroke in the Chinese clinical setting, after the appropriate reduction of some categories according to Chinese patients' characteristics and culture.

  19. Preliminary engineering design of sodium-cooled CANDLE core

    Science.gov (United States)

    Takaki, Naoyuki; Namekawa, Azuma; Yoda, Tomoyuki; Mizutani, Akihiko; Sekimoto, Hiroshi

    2012-06-01

    The CANDLE burning process is characterized by the autonomous shifting of burning region with constant reactivity and constant spacial power distribution. Evaluations of such critical burning process by using widely used neutron diffusion and burning codes under some realistic engineering constraints are valuable to confirm the technical feasibility of the CANDLE concept and to put the idea into concrete core design. In the first part of this paper, it is discussed that whether the sustainable and stable CANDLE burning process can be reproduced even by using conventional core analysis tools such as SLAROM and CITATION-FBR. As a result, it is certainly possible to demonstrate it if the proper core configuration and initial fuel composition required as CANDLE core are applied to the analysis. In the latter part, an example of a concrete image of sodium cooled, metal fuel, 2000MWt rating CANDLE core has been presented by assuming an emerging inevitable technology of recladding. The core satisfies engineering design criteria including cladding temperature, pressure drop, linear heat rate, and cumulative damage fraction (CDF) of cladding, fast neutron fluence and sodium void reactivity which are defined in the Japanese FBR design project. It can be concluded that it is feasible to design CADLE core by using conventional codes while satisfying some realistic engineering design constraints assuming that recladding at certain time interval is technically feasible.

  20. The expanded FindCore method for identification of a core atom set for assessment of protein structure prediction.

    Science.gov (United States)

    Snyder, David A; Grullon, Jennifer; Huang, Yuanpeng J; Tejero, Roberto; Montelione, Gaetano T

    2014-02-01

    Maximizing the scientific impact of NMR-based structure determination requires robust and statistically sound methods for assessing the precision of NMR-derived structures. In particular, a method to define a core atom set for calculating superimpositions and validating structure predictions is critical to the use of NMR-derived structures as targets in the CASP competition. FindCore (Snyder and Montelione, Proteins 2005;59:673-686) is a superimposition independent method for identifying a core atom set and partitioning that set into domains. However, as FindCore optimizes superimposition by sensitively excluding not-well-defined atoms, the FindCore core may not comprise all atoms suitable for use in certain applications of NMR structures, including the CASP assessment process. Adapting the FindCore approach to assess predicted models against experimental NMR structures in CASP10 required modification of the FindCore method. This paper describes conventions and a standard protocol to calculate an "Expanded FindCore" atom set suitable for validation and application in biological and biophysical contexts. A key application of the Expanded FindCore method is to identify a core set of atoms in the experimental NMR structure for which it makes sense to validate predicted protein structure models. We demonstrate the application of this Expanded FindCore method in characterizing well-defined regions of 18 NMR-derived CASP10 target structures. The Expanded FindCore protocol defines "expanded core atom sets" that match an expert's intuition of which parts of the structure are sufficiently well defined to use in assessing CASP model predictions. We also illustrate the impact of this analysis on the CASP GDT assessment scores.

  1. Development of ICF Core Sets to standardize assessment of functioning and impairment in ADHD: the path ahead.

    Science.gov (United States)

    Bölte, Sven; de Schipper, Elles; Holtmann, Martin; Karande, Sunil; de Vries, Petrus J; Selb, Melissa; Tannock, Rosemary

    2014-12-01

    In the study of health and quality of life in attention deficit/hyperactivity disorder (ADHD), it is of paramount importance to include assessment of functioning. The International Classification of Functioning, Disability and Health (ICF) provides a comprehensive, universally accepted framework for the description of functioning in relation to health conditions. In this paper, the authors outline the process to develop ICF Core Sets for ADHD. ICF Core Sets are subgroups of ICF categories selected to capture the aspects of functioning that are most likely to be affected in specific disorders. The ICF categories that will be included in the ICF Core Sets for ADHD will be determined at an ICF Core Set Consensus Conference, wherein evidence from four preliminary studies (a systematic review, an expert survey, a patient and caregiver qualitative study, and a clinical cross-sectional study) will be integrated. Comprehensive and Brief ICF Core Sets for ADHD will be developed with the goal of providing useful standards for research and clinical practice, and to generate a common language for the description of functioning in ADHD in different areas of life and across the lifespan.

  2. CONSIDER - Core Outcome Set in IAD Research: study protocol for establishing a core set of outcomes and measurements in incontinence-associated dermatitis research.

    Science.gov (United States)

    Van den Bussche, Karen; De Meyer, Dorien; Van Damme, Nele; Kottner, Jan; Beeckman, Dimitri

    2017-10-01

    This study protocol describes the methodology for the development of a core set of outcomes and a core set of measurements for incontinence-associated dermatitis. Incontinence is a widespread disorder with an important impact on quality of life. One of the most common complications is incontinence-associated dermatitis, resulting from chemical and physical irritation of the skin barrier, triggering inflammation and skin damage. Managing incontinence-associated dermatitis is an important challenge for nurses. Several interventions have been assessed in clinical trials, but heterogeneity in study outcomes complicates the comparability and standardization. To overcome this challenge, the development of a core outcome set, a minimum set of outcomes and measurements to be assessed in clinical research, is needed. A project team, International Steering Committee and panelists will be involved to guide the development of the core outcome set. The framework of the Harmonizing Outcomes Measures for Eczema roadmap endorsed by Cochrane Skin Group Core Outcomes Set Initiative, is used to inform the project design. A systematic literature review, interviews to integrate the patients' perspective and a consensus study with healthcare researchers and providers using the Delphi procedure will be performed. The project was approved by the Ethics review Committee (April 2016). This is the first project that will identify a core outcome set of outcomes and measurements for incontinence-associated dermatitis research. A core outcome set will reduce possible reporting bias, allow results comparisons and statistical pooling across trials and strengthen evidence-based practice and decision-making. This project has been registered in the Core Outcome Measures in Effectiveness Trials (COMET) database and is part of the Cochrane Skin Group Core Outcomes Set Initiative (CSG-COUSIN). © 2016 John Wiley & Sons Ltd.

  3. Preliminary Uncertainty Analysis for SMART Digital Core Protection and Monitoring System

    Energy Technology Data Exchange (ETDEWEB)

    Koo, Bon Seung; In, Wang Kee; Hwang, Dae Hyun [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2012-05-15

    The Korea Atomic Energy Research Institute (KAERI) developed on-line digital core protection and monitoring systems, called SCOPS and SCOMS as a part of SMART plant protection and monitoring system. SCOPS simplified the protection system by directly connecting the four RSPT signals to each core protection channel and eliminated the control element assembly calculator (CEAC) hardware. SCOMS adopted DPCM3D method in synthesizing core power distribution instead of Fourier expansion method being used in conventional PWRs. The DPCM3D method produces a synthetic 3-D power distribution by coupling a neutronics code and measured in-core detector signals. The overall uncertainty analysis methodology which is used statistically combining uncertainty components of SMART core protection and monitoring system was developed. In this paper, preliminary overall uncertainty factors for SCOPS/SCOMS of SMART initial core were evaluated by applying newly developed uncertainty analysis method

  4. Signatures of core perturbations in geomagnetic field dynamics - preliminary results

    Science.gov (United States)

    Bury, Agata; Mizerski, Krzysztof

    2017-04-01

    Earth's magnetic field is continuously evolving in time. Research is carried out in order to understand it's characteristics and also to describe types of perturbations which can exist in the Earth's liquid core. The aim of this work is to analyze the geomagnetic ground observatory data for the occurrence of magnetohydrodynamic (MHD) waves described in literature traveling at the top of the Earth's liquid core. Hourly means data from 150 observatories collected from the World Data Center for Geomagnetism (WDC) were used in this work. Local topocentric magnetic field components: X (East), Y (North), Z (vertical), and also spherical coordinates: Br, Bθ, BΦ were analyzed. Hourly means were averaged to one day means and to one month means, missing values were interpolated by different methods. Fourier analysis and Empirical Mode Decomposition (EMD) method were applied to extract periods of oscillations visible in datasets. Similar analysis was also made for data generated from the IGRF12 model for comparison. The times associated with peaks within these data were identified for all components and plotted versus colatitude and longitude to find possible travelling perturbations. Possible candidates of MHD waves for future investigation will be presented.

  5. Core outcome sets in women's and newborn health: a systematic review.

    Science.gov (United States)

    Duffy, Jmn; Rolph, R; Gale, C; Hirsch, M; Khan, K S; Ziebland, S; McManus, R J

    2017-09-01

    Variation in outcome collection and reporting is a serious hindrance to progress in our specialty; therefore, over 80 journals have come together to support the development, dissemination, and implementation of core outcome sets. This study systematically reviewed and characterised registered, progressing, or completed core outcome sets relevant to women's and newborn health. Systematic search using the Core Outcome Measures in Effectiveness Trial initiative and the Core Outcomes in Women's and Newborn Health initiative databases. Registry entries, protocols, systematic reviews, and core outcome sets. Descriptive statistics to describe characteristics and results. There were 49 core outcome sets registered in maternal and newborn health, with the majority registered in 2015 (n = 22; 48%) or 2016 (n = 16; 32%). Benign gynaecology (n = 8; 16%) and newborn health (n = 3; 6%) are currently under-represented. Twenty-four (52%) core outcome sets were funded by international (n = 1; core outcome sets were completed: reconstructive breast surgery (11 outcomes), preterm birth (13 outcomes), epilepsy in pregnancy (29 outcomes), and maternity care (48 outcomes). The quantitative, qualitative, and consensus methods used to develop core outcome sets varied considerably. Core outcome sets are currently being developed across women's and newborn health, although coverage of topics is variable. Development of further infrastructure to develop, disseminate, and implement core outcome sets is urgently required. Forty-nine women's and newborn core outcome sets registered. 50% funded. 7 protocols, 20 systematic reviews, and 4 core outcome sets published. @coreoutcomes @jamesmnduffy. © 2017 Royal College of Obstetricians and Gynaecologists.

  6. Dendritic iodinated contrast agents with PEG-cores for CT imaging: synthesis and preliminary characterization.

    Science.gov (United States)

    Fu, Yanjun; Nitecki, Danute E; Maltby, David; Simon, Gerhard H; Berejnoi, Kirill; Raatschen, Hans-Juergen; Yeh, Benjamin M; Shames, David M; Brasch, Robert C

    2006-01-01

    The purpose of this study was to design, synthesize, and initially characterize a representative set of novel constructs for large-molecular radiographic/computed tomography (CT) contrast agents, intended for a primarily intravascular distribution. A new assembly of well-known and biocompatible components consists of paired, symmetrical dendritic polylysines initiated from both ends of a poly(ethylene glycol) (PEG) core, yielding an array of multiple free amino groups to which were conjugated highly soluble and stable triiodophthalamide ("triiodo") moieties. An array of six dendritic contrast agents was synthesized originally, using three different PEG cores (3, 6, 12 kDa) with t-Boc lysine-generated dendrimer "amplifiers" (from three to five generations) containing 16 to 64 amino groups for conjugation with reactive triiodo moieties. A clinically used, nonionic, small molecular CT contrast agent, iobitridol, was derivatized via a hydroxyl protection/deprotection strategy, introducing a new carboxyl group available for conjugation to the lysine amino groups of dendrimers. Final products were purified by size exclusion chromatography and characterized by NMR, UV, HPLC, and elemental analysis. Preliminary evaluations were conducted for physicochemical characterization and in vivo CT contrast enhancement in a rat model. All six iodinated PEG-core dendrimer conjugates were synthesized in good yields, with a high degree of size monodispersity, large apparent molecular weight, favored physicochemical properties. A representative compound, PEG12000-carbamate-Gen4-IOB conjugate, 27% (w%) rich in iodine, demonstrated a desirable strong and persistent intravascular enhancement with a monoexponential blood half-life of approximately 35 min assayed by dynamic CT imaging and also showed high water solubility (>550 mg/mL at 25 degrees C), large apparent molecular size (comparable to a 143-kDa protein), high hydrophilicity (butanol-water partition coefficient 0.015), and

  7. Density-based cluster algorithms for the identification of core sets

    Science.gov (United States)

    Lemke, Oliver; Keller, Bettina G.

    2016-10-01

    The core-set approach is a discretization method for Markov state models of complex molecular dynamics. Core sets are disjoint metastable regions in the conformational space, which need to be known prior to the construction of the core-set model. We propose to use density-based cluster algorithms to identify the cores. We compare three different density-based cluster algorithms: the CNN, the DBSCAN, and the Jarvis-Patrick algorithm. While the core-set models based on the CNN and DBSCAN clustering are well-converged, constructing core-set models based on the Jarvis-Patrick clustering cannot be recommended. In a well-converged core-set model, the number of core sets is up to an order of magnitude smaller than the number of states in a conventional Markov state model with comparable approximation error. Moreover, using the density-based clustering one can extend the core-set method to systems which are not strongly metastable. This is important for the practical application of the core-set method because most biologically interesting systems are only marginally metastable. The key point is to perform a hierarchical density-based clustering while monitoring the structure of the metric matrix which appears in the core-set method. We test this approach on a molecular-dynamics simulation of a highly flexible 14-residue peptide. The resulting core-set models have a high spatial resolution and can distinguish between conformationally similar yet chemically different structures, such as register-shifted hairpin structures.

  8. 中文版下背痛简明ICF核心要素及其效度与信度的初步研究%A preliminary study of the brief Chinese version of the ICF core sets for low back pain and their validity and reliability

    Institute of Scientific and Technical Information of China (English)

    夏文广; 郭铁成; 郑婵娟; 华强; 余兰芬; 张阳普

    2008-01-01

    Objective To develop a brief Chinese version of the International Classification of Functioning,Disability,and Health(ICF)core sets for low back pain and to test their validity and reliability. Methods The through clinical investigation.Sixty patients with low back pain were then recruited and evaluated using the Chinese sets,the Oswestry disability index(ODI)and the Roland-Moms Disability Questionnaire(RMDQ).Thirty patients were selected randomly and examined again with the Chinese ICF core sets 2 days after the 1st evaluation to test their repeatability.Pearson correlation analysis between the ICF core sets and the other scales was conducted to test the validity of the brief ICF core sets for Chinese patients with low back pain. Results The Pearson correlation analysis revealed a significant relationship between the results with the Chinese ICF core sets and ODI and RMDQ results.The Chinese ICF core sets were also found to have good repeatability. Conclusion The brief Chinese version of the ICF core sets is reliable and valid in the evaluation of Chinese patients with low back pain.%目的 探讨中文版下背痛简明"国际功能、残疾和健康分类"(ICF)核心要素的组成,并检验其应用于下背痛患者的信度和效度.方法 参照国外ICF核心要素量表制定中文版下背痛简明ICF核心要素量表并应用于下背痛患者,确定该量表所包括的条目.同时采用中文版Oswestry功能障碍指数(ODI)和Roland-Moms功能障碍调查表(RMDQ),并结合患者自我报告、临床记录、医学检查等方法,对60例下背痛患者进行综合测评.将下背痛患者的简明ICF核心要素与中文版Oswestry功能障碍指数以及Roland-Morris功能障碍调查表评分进行相关性分析,2 d后重复测评ICF核心要素,评估其重测信度.结果 简明ICF核心要素量表的有效性测评结果显示其与ODI、RMDQ有显著相关性;ICF核心要素量表具有良好的可重复性.结论 下背痛简明ICF核心

  9. Using a situational judgement test for selection into dental core training: a preliminary analysis.

    Science.gov (United States)

    Rowett, E; Patterson, F; Cousans, F; Elley, K

    2017-05-12

    Objective and setting This paper describes the evaluation of a pilot situational judgement test (SJT) for selection into UK Dental Core Training (DCT). The SJT's psychometric properties, group differences based on gender and ethnicity, and candidate reactions were assessed.Methods The SJT targets four non-academic attributes important for success in DCT. Data were collected alongside live selection processes from five Health Education England local teams in the UK (N = 386). Candidates completed the pilot SJT and an evaluation questionnaire to examine their reactions to the test.Results SJT scores were relatively normally distributed and showed acceptable levels of internal reliability (α = 0.68). Difficulty level and partial correlations between scenarios and SJT total score were in the expected ranges (64.61% to 90.03% and r = 0.06 to 0.41, respectively). No group differences were found for gender, and group differences between White and BME candidates were minimal. Most candidates perceived the SJT as relevant to the target role, appropriate and fair.Conclusions This study demonstrated the potential suitability of an SJT for use in DCT selection. Future research should replicate these preliminary findings in other cohorts, and assess the predictive validity of the SJT for predicting key training and practice-based outcomes.

  10. Text Sets, Deep Learning, and the Common Core

    Science.gov (United States)

    Donham, Jean

    2013-01-01

    The Common Core Curriculum Standards point educators toward rigorous or deep learning so that students will become "college and career ready." College-ready students engage with text in thoughtful ways so that they arrive at insights through interpretation, discussion, and analysis. One reading anchor standard of relevance for school…

  11. Text Sets, Deep Learning, and the Common Core

    Science.gov (United States)

    Donham, Jean

    2013-01-01

    The Common Core Curriculum Standards point educators toward rigorous or deep learning so that students will become "college and career ready." College-ready students engage with text in thoughtful ways so that they arrive at insights through interpretation, discussion, and analysis. One reading anchor standard of relevance for school…

  12. Preliminaries on core image analysis using fault drilling samples; Core image kaiseki kotohajime (danso kussaku core kaisekirei)

    Energy Technology Data Exchange (ETDEWEB)

    Miyazaki, T.; Ito, H. [Geological Survey of Japan, Tsukuba (Japan)

    1996-05-01

    This paper introduces examples of image data analysis on fault drilling samples. The paper describes the following matters: core samples used in the analysis are those obtained from wells drilled piercing the Nojima fault which has moved in the Hygoken-Nanbu Earthquake; the CORESCAN system made by DMT Corporation, Germany, used in acquiring the image data consists of a CCD camera, a light source and core rotation mechanism, and a personal computer, its resolution being about 5 pixels/mm in both axial and circumferential directions, and 24-bit full color; with respect to the opening fractures in core samples collected by using a constant azimuth coring, it was possible to derive values of the opening width, inclination angle, and travel from the image data by using a commercially available software for the personal computer; and comparison of this core image with the BHTV record and the hydrophone VSP record (travel and inclination obtained from the BHTV record agree well with those obtained from the core image). 4 refs., 4 figs.

  13. Parsing Combinatory Categorial Grammar with Answer Set Programming: Preliminary Report

    CERN Document Server

    Lierler, Yuliya

    2011-01-01

    Combinatory categorial grammar (CCG) is a grammar formalism used for natural language parsing. CCG assigns structured lexical categories to words and uses a small set of combinatory rules to combine these categories to parse a sentence. In this work we propose and implement a new approach to CCG parsing that relies on a prominent knowledge representation formalism, answer set programming (ASP) - a declarative programming paradigm. We formulate the task of CCG parsing as a planning problem and use an ASP computational tool to compute solutions that correspond to valid parses. Compared to other approaches, there is no need to implement a specific parsing algorithm using such a declarative method. Our approach aims at producing all semantically distinct parse trees for a given sentence. From this goal, normalization and efficiency issues arise, and we deal with them by combining and extending existing strategies. We have implemented a CCG parsing tool kit - AspCcgTk - that uses ASP as its main computational mean...

  14. Language core values in a multicultural setting: An Australian experience

    Science.gov (United States)

    Smolicz, Jerzy J.

    1991-03-01

    While it has been agreed by the members of the European Community (except the UK) that all secondary students should study two EC languages in addition to their own, in Australia the recent emphasis has been on teaching languages for external trade, particularly in the Asian region. This policy over-looks the 13 per cent of the Australian population who already speak a language other than English at home (and a greater number who are second generation immigrants), and ignores the view that it is necessary to foster domestic multiculturalism in order to have fruitful links with other cultures abroad. During the 1980s there have been moves to reinforce the cultural identity of Australians of non-English speaking background, but these have sometimes been half-hearted and do not fully recognise that cultural core values, including language, have to achieve a certain critical mass in order to be sustainable. Without this recognition, semi-assimilation will continue to waste the potential cultural and economic contributions of many citizens, and to lead to frustration and eventual violence. The recent National Agenda for a Multicultural Australia addresses this concern.

  15. Public Experiments and Displays of Virtuosity: The Core-Set Revisited.

    Science.gov (United States)

    Collins, H. M.

    1988-01-01

    Makes use of distinctions between experiment and demonstrations to resolve a paradox for the sociology of scientific knowledge. Describes two public tests which illustrate these themes. Discusses types of core-set distortion and suggests a partial solution. (YP)

  16. Tecuamburro Volcano, Guatemala geothermal gradient core hole drilling, operations, and preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Goff, S.; Heiken, G.; Goff, F.; Gardner, J. (Los Alamos National Lab., NM (USA)); Duffield, W. (Geological Survey, Flagstaff, AZ (USA)); Martinelli, L.; Aycinena, S. (Swissboring Overseas Corp. Ltd., Guatemala City (Guatemala)); Castaneda, O. (Unidad de Desarrollo Geotermico, Guatemala City (Guatemala). Inst. Nacional de Electrificacion)

    1990-01-01

    A geothermal gradient core hole (TCB-1) was drilled to a depth of 700+ m at the Tecuamburro geothermal site, Guatemala during February and March, 1990. The core hole is located low on the northern flank of the Tecuamburro Volcano complex. Preliminary analysis of cores (>98% core recovery) indicates that the hydrothermal system may be centered in the 4-km-diameter Chupadero Crater, which has been proposed as the source of pyroxene pumice deposits in the Tecuamburro area. TCB-1 is located 300 m south of a 300-m-diameter phreatic crater, Laguna Ixpaco; the core hole penetrates the thin edge of a tuff ring surrounding Ixpaco and zones of hydrothermal brecciation within the upper 150 m may be related to the phreatic blast, dated at 2,910 {sup 14}C years. At the time of this writing, the unequilibrated temperature at a depth of 570m was 180{degree}C. Data on fracturing, permeability, hydrothermal alteration, and temperature will be presented. 3 refs., 3 figs.

  17. Development of consensus International Classification of Functioning, Disability and Health (ICF) core sets for lymphedema.

    Science.gov (United States)

    Viehoff, P B; Heerkens, Y F; Van Ravensberg, C D; Hidding, J; Damstra, R J; Ten Napel, H; Neumann, H A M

    2015-03-01

    To understand the challenges of patients with lymphedema it is important to describe functioning and to measure the effectiveness of treatment in changing functioning. The International Classification of Functioning, Disability and Health (ICF) offers an international framework to classify functioning of persons in their personal environment. ICF Core Sets are lists of selected ICF categories concerning those important aspects of functioning that are most likely to be affected by a specific health problem or disease. These Core Sets make it easier and faster to describe and communicate the patient's problems and to define treatment goals. Furthermore, they are available to health care providers of all professions, researchers, health insurance companies and policy-makers. The objective of this document is to present the outcomes of a consensus conference held to determine the first versions of the ICF Core Sets for lymphedema. Frequency rankings were made of the ICF categories derived from four preparatory studies, being: a) a systematic review; b) a qualitative study; c) an expert survey; and d) a cross-sectional study. By means of working group discussions and plenary sessions, a final consensus on ICF categories was achieved and Comprehensive and Brief Core Sets for lymphedema for the upper limb, lower limb, and midline lymphedema were defined. These ICF Core Sets contain different items in each region. Future validation of these Core Sets for health professions and for countries is needed.

  18. Environmental Indicators. A Preliminary Set = Indicateurs d'environnement. Une etude pilote.

    Science.gov (United States)

    Organisation for Economic Cooperation and Development, Paris (France).

    This document provides a preliminary set of environmental indicators by which to measure environmental performance. The indicators are patterned on the outline of the Organisation for Economic Cooperation and Development (OECD) "Report on the State of the Environment," a companion volume published in the same year. This volume is comprised of 18…

  19. Environmental Indicators. A Preliminary Set = Indicateurs d'environnement. Une etude pilote.

    Science.gov (United States)

    Organisation for Economic Cooperation and Development, Paris (France).

    This document provides a preliminary set of environmental indicators by which to measure environmental performance. The indicators are patterned on the outline of the Organisation for Economic Cooperation and Development (OECD) "Report on the State of the Environment," a companion volume published in the same year. This volume is…

  20. Development and preliminary verification of the 3D core neutronic code: COCO

    Energy Technology Data Exchange (ETDEWEB)

    Lu, H.; Mo, K.; Li, W.; Bai, N.; Li, J. [Reactor Design and Fuel Management Research Center, China Nuclear Power Technology Research Inst., 47F/A Jiangsu Bldg., Yitian Road, Futian District, Shenzhen (China)

    2012-07-01

    As the recent blooming economic growth and following environmental concerns (China)) is proactively pushing forward nuclear power development and encouraging the tapping of clean energy. Under this situation, CGNPC, as one of the largest energy enterprises in China, is planning to develop its own nuclear related technology in order to support more and more nuclear plants either under construction or being operation. This paper introduces the recent progress in software development for CGNPC. The focus is placed on the physical models and preliminary verification results during the recent development of the 3D Core Neutronic Code: COCO. In the COCO code, the non-linear Green's function method is employed to calculate the neutron flux. In order to use the discontinuity factor, the Neumann (second kind) boundary condition is utilized in the Green's function nodal method. Additionally, the COCO code also includes the necessary physical models, e.g. single-channel thermal-hydraulic module, burnup module, pin power reconstruction module and cross-section interpolation module. The preliminary verification result shows that the COCO code is sufficient for reactor core design and analysis for pressurized water reactor (PWR). (authors)

  1. Relationship of core self-evaluations to goal setting, motivation, and performance.

    Science.gov (United States)

    Erez, A; Judge, T A

    2001-12-01

    A newly developed personality taxonomy suggests that self-esteem, locus of control, generalized self-efficacy, and neuroticism form a broad personality trait termed core self-evaluations. The authors hypothesized that this broad trait is related to motivation and performance. To test this hypothesis, 3 studies were conducted. Study 1 showed that the 4 dispositions loaded on 1 higher order factor. Study 2 demonstrated that the higher order trait was related to task motivation and performance in a laboratory setting. Study 3 showed that the core trait was related to task activity, productivity as measured by sales volume, and the rated performance of insurance agents. Results also revealed that the core self-evaluations trait was related to goal-setting behavior. In addition, when the 4 core traits were investigated as 1 nomological network, they proved to be more consistent predictors of job behaviors than when used in isolation.

  2. Identification of preliminary core outcome domains for communication about childhood vaccination: An online Delphi survey.

    Science.gov (United States)

    Kaufman, Jessica; Ryan, Rebecca; Lewin, Simon; Bosch-Capblanch, Xavier; Glenton, Claire; Cliff, Julie; Oyo-Ita, Angela; Muloliwa, Artur Manuel; Oku, Afiong; Ames, Heather; Rada, Gabriel; Cartier, Yuri; Hill, Sophie

    2017-08-20

    Communication interventions for childhood vaccination are promising strategies to address vaccine hesitancy, but current research is limited by the outcomes measured. Most studies measure only vaccination-related outcomes, with minimal consideration of vaccine hesitancy-relevant intermediate outcomes. This impedes understanding of which interventions or elements are effective. It is also unknown which outcomes are important to the range of stakeholders affected by vaccine hesitancy. Outcome selection shapes the evidence base, informing future interventions and trials, and should reflect stakeholder priorities. Therefore, our aim was to identify which outcome domains (i.e. broad outcome categories) are most important to different stakeholders, identifying preliminary core outcome domains to inform evaluation of three common vaccination communication types: (i) communication to inform or educate, (ii) remind or recall, and (iii) enhance community ownership. We conducted a two-stage online Delphi survey, involving four stakeholder groups: parents or community members, healthcare providers, researchers, and government or non-governmental organisation representatives. Participants rated the importance of eight outcome domains for each of the three communication types. They also rated specific outcomes within one domain ("attitudes or beliefs") and provided feedback about the survey. Collectively, stakeholder groups prioritised outcome domains differently when considering the effects of different communication types. For communication that aims to (i) inform or educate, the most important outcome domain is "knowledge or understanding"; for (ii) reminder communication, "vaccination status and behaviours"; and for (iii) community engagement communication, "community participation". All stakeholder groups rated most outcome domains as very important or critical. The highest rated specific outcome within the "attitudes or beliefs" domain was "trust". This Delphi survey

  3. Development of a Draft Core Set of Domains for Measuring Shared Decision Making in Osteoarthritis

    DEFF Research Database (Denmark)

    Toupin-April, Karine; Barton, Jennifer; Fraenkel, Liana;

    2015-01-01

    the decision into practice, and (7) assessing the effect of the decision. Contextual factors were also suggested. CONCLUSION: We proposed a draft core set of shared decision-making domains for OA intervention research studies. Next steps include a workshop at OMERACT 13 to reach consensus on these proposed......OBJECTIVE: Despite the importance of shared decision making for delivering patient-centered care in rheumatology, there is no consensus on how to measure its process and outcomes. The aim of this Outcome Measures in Rheumatology (OMERACT) working group is to determine the core set of domains...... for measuring shared decision making in intervention studies in adults with osteoarthritis (OA), from the perspectives of patients, health professionals, and researchers. METHODS: We followed the OMERACT Filter 2.0 method to develop a draft core domain set by (1) forming an OMERACT working group; (2) conducting...

  4. Preliminary Thermal Hydraulic Analyses of the Conceptual Core Models with Tubular Type Fuel Assemblies

    Energy Technology Data Exchange (ETDEWEB)

    Chae, Hee Taek; Park, Jong Hark; Park, Cheol

    2006-11-15

    A new research reactor (AHR, Advanced HANARO Reactor) based on the HANARO has being conceptually developed for the future needs of research reactors. A tubular type fuel was considered as one of the fuel options of the AHR. A tubular type fuel assembly has several curved fuel plates arranged with a constant small gap to build up cooling channels, which is very similar to an annulus pipe with many layers. This report presents the preliminary analysis of thermal hydraulic characteristics and safety margins for three conceptual core models using tubular fuel assemblies. Four design criteria, which are the fuel temperature, ONB (Onset of Nucleate Boiling) margin, minimum DNBR (Departure from Nucleate Boiling Ratio) and OFIR (Onset of Flow Instability Ratio), were investigated along with various core flow velocities in the normal operating conditions. And the primary coolant flow rate based a conceptual core model was suggested as a design information for the process design of the primary cooling system. The computational fluid dynamics analysis was also carried out to evaluate the coolant velocity distributions between tubular channels and the pressure drop characteristics of the tubular fuel assembly.

  5. An inventory of United States and Canadian growth record sets: preliminary report.

    Science.gov (United States)

    Hunter, W S; Baumrind, S; Moyers, R E

    1993-06-01

    A listing and description of longitudinal craniofacial growth record sets currently extant on the North American continent is provided. An argument is made for the preservation of these resources and for the generation of a pooled or shared image base of duplicate craniofacial physical records. This is a preliminary report and is assumed to be incomplete. In an effort to improve our accuracy and completeness, we invite corrections and additions.

  6. Cost-based optimization of a nuclear reactor core design: a preliminary model

    Energy Technology Data Exchange (ETDEWEB)

    Sacco, Wagner F.; Alves Filho, Hermes [Universidade do Estado do Rio de Janeiro (UERJ), Nova Friburgo, RJ (Brazil). Inst. Politecnico. Dept. de Modelagem Computacional]. E-mails: wfsacco@iprj.uerj.br; halves@iprj.uerj.br; Pereira, Claudio M.N.A. [Instituto de Engenharia Nuclear (IEN), Rio de Janeiro, RJ (Brazil). Div. de Reatores]. E-mail: cmnap@ien.gov.br

    2007-07-01

    A new formulation of a nuclear core design optimization problem is introduced in this article. Originally, the optimization problem consisted in adjusting several reactor cell parameters, such as dimensions, enrichment and materials, in order to minimize the radial power peaking factor in a three-enrichment zone reactor, considering restrictions on the average thermal flux, criticality and sub-moderation. Here, we address the same problem using the minimization of the fuel and cladding materials costs as the objective function, and the radial power peaking factor as an operational constraint. This cost-based optimization problem is attacked by two metaheuristics, the standard genetic algorithm (SGA), and a recently introduced Metropolis algorithm called the Particle Collision Algorithm (PCA). The two algorithms are submitted to the same computational effort and their results are compared. As the formulation presented is preliminary, more elaborate models are also discussed (author)

  7. Twin-Twin Transfusion Syndrome: study protocol for developing, disseminating, and implementing a core outcome set.

    Science.gov (United States)

    Khalil, Asma; Perry, Helen; Duffy, James; Reed, Keith; Baschat, Ahmet; Deprest, Jan; Hecher, Kurt; Lewi, Liesbeth; Lopriore, Enrico; Oepkes, Dick

    2017-07-14

    Twin-Twin Transfusion Syndrome (TTTS) is associated with an increased risk of perinatal mortality and morbidity. Several treatment interventions have been described for TTTS, including fetoscopic laser surgery, amnioreduction, septostomy, expectant management, and pregnancy termination. Over the last decade, fetoscopic laser surgery has become the primary treatment. The literature to date reports on many different outcomes, making it difficult to compare results or combine data from individual studies, limiting the value of research to guide clinical practice. With the advent and ongoing development of new therapeutic techniques, this is more important than ever. The development and use of a core outcome set has been proposed to address these issues, prioritising outcomes important to the key stakeholders, including patients. We aim to produce, disseminate, and implement a core outcome set for TTTS. An international steering group has been established to oversee the development of this core outcome set. This group includes healthcare professionals, researchers and patients. A systematic review is planned to identify previously reported outcomes following treatment for TTTS. Following completion, the identified outcomes will be evaluated by stakeholders using an international, multi-perspective online modified Delphi method to build consensus on core outcomes. This method encourages the participants towards consensus 'core' outcomes. All key stakeholders will be invited to participate. The steering group will then hold a consensus meeting to discuss results and form a core outcome set to be introduced and measured. Once core outcomes have been agreed, the next step will be to determine how they should be measured, disseminated, and implemented within an international context. The development, dissemination, and implementation of a core outcome set in TTTS will enable its use in future clinical trials, systematic reviews and clinical practice guidelines. This is

  8. International patient and physician consensus on a psoriatic arthritis core outcome set for clinical trials

    DEFF Research Database (Denmark)

    Orbai, Ana-Maria; de Wit, Maarten; Mease, Philip

    2016-01-01

    OBJECTIVE: To identify a core set of domains (outcomes) to be measured in psoriatic arthritis (PsA) clinical trials that represent both patients' and physicians' priorities. METHODS: We conducted (1) a systematic literature review (SLR) of domains assessed in PsA; (2) international focus groups t...

  9. International Spinal Cord Injury Core Data Set (version 2.0)-including standardization of reporting

    NARCIS (Netherlands)

    Biering-Sorensen, F.; DeVivo, M. J.; Charlifue, S.; Chen, Y.; New, P. W.; Noonan, V.; Post, M. W. M.; Vogel, L.

    2017-01-01

    Study design: The study design includes expert opinion, feedback, revisions and final consensus. Objectives: The objective of the study was to present the new knowledge obtained since the International Spinal Cord Injury (SCI) Core Data Set (Version 1.0) published in 2006, and describe the adjustmen

  10. Classification of functioning and impairment: the development of ICF core sets for autism spectrum disorder.

    Science.gov (United States)

    Bölte, Sven; de Schipper, Elles; Robison, John E; Wong, Virginia C N; Selb, Melissa; Singhal, Nidhi; de Vries, Petrus J; Zwaigenbaum, Lonnie

    2014-02-01

    Given the variability seen in Autism Spectrum Disorder (ASD), accurate quantification of functioning is vital to studying outcome and quality of life in affected individuals. The International Classification of Functioning, Disability and Health (ICF) provides a comprehensive, universally accepted framework for the description of health-related functioning. ICF Core Sets are shortlists of ICF categories that are selected to capture those aspects of functioning that are most relevant when describing a person with a specific condition. In this paper, the authors preview the process for developing ICF Core Sets for ASD, a collaboration with the World Health Organization and the ICF Research Branch. The ICF Children and Youth version (ICF-CY) was derived from the ICF and designed to capture the specific situation of the developing child. As ASD affects individuals throughout the life span, and the ICF-CY includes all ICF categories, the ICF-CY will be used in this project ("ICF(-CY)" from now on). The ICF(-CY) categories to be included in the ICF Core Sets for ASD will be determined at an ICF Core Set Consensus Conference, where evidence from four preparatory studies (a systematic review, an expert survey, a patient and caregiver qualitative study, and a clinical cross-sectional study) will be integrated. Comprehensive and Brief ICF Core Sets for ASD will be developed with the goal of providing useful standards for research and clinical practice and generating a common language for functioning and impairment in ASD in different areas of life and across the life span.

  11. Creating Innovators through setting up organizational Vision, Mission, and Core Values : a Strategic Model in Higher Education

    OpenAIRE

    Aithal, Sreeramana

    2016-01-01

    Vision, mission, objectives and core values play major role in setting up sustainable organizations. Vision and mission statements describe the organization’s goals. Core values and core principles represent the organization’s culture. In this paper, we have discussed a model on how a higher education institution can prosper to reach its goal of ‘creating innovators’ through its vision, mission, objectives and core values. A model for the core values required for a prospective ...

  12. Preliminary evidence indicating Dome A(Antarctica) satisfying preconditions for drilling the oldest ice core

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Lowest temperature and snow accumulation rate are preconditions for retrieving the oldest ice core from the polar ice sheets.The 10-m depth firn temperature at Dome A,the summit of the Antaretie Ice Sheet,recorded by an automatic weather station(AWS)was-58.3℃in 2005 and-58.2℃in 2006,respectively.The 10-m firn temperature is an approximation of the annual mean air temperature(AMAT),and this is the lowest AMAT that has been recorded on the surface of the Earth.The stable isotopic ratios(δ18O and δD)of surface snow at Dome A are also lower than at other ice sheet domes along the East Antarctic Ice Divide such as Dome C,Dome F,Dome B and Vostok.These facts indicate that Dome A is the"pole of cold"on the Earth.The total amount of snow accumulation rate in 2005 and 2006 was only 0.16 cm,equaling 0.016 m water equivalent per year,the lowest precipitation ever recorded from Antarctica.Preliminary evidences indicate that Dome A is a candidate site for recovering the oldest ice core.

  13. Preliminary Analysis of Gene Expression Profiles in HepG2 Cell Line Induced by Different Genotype Core Proteins of HCV

    Institute of Scientific and Technical Information of China (English)

    Jun Dou; Pengbo Liu; Jing Wang; Xinjian Zhang

    2006-01-01

    In present investigation, we constructed recombinants expressing the HCV genotypes 1b, 2a, and 4d core proteins,and established human hepatocellular carcinoma (HepG2) cell line that expressed various genotype core proteins.The gene expression profiles in the cells expressing different HCV genotype core proteins were compared with those in the control by microarray analysis. In data analysis, a threshold was set to eliminate all genes that were not increased or decreased by 2.5-fold change in a comparison between the transfected cells and control cells. The preliminary microarray analysis suggests that the gene expression profiles regulated by three kinds of genotype core proteins are mainly involved in transport, signal transduction, regulation of transcription, protease activity, etc.,and that some pathogenesis/oncogenesis gene expressions are up/down- regulated simultaneously in the HepG2 cell line. The data suggest that each core protein has its gene expressions profile and that the profiles are implicated in HCV replication and pathogenesis, which may open up a novel way to understand the function of the HCV variant core proteins biological and their pathogenic mechanism.

  14. Analysis of a German BWR core with TRACE/PARCS using different cross section sets

    Energy Technology Data Exchange (ETDEWEB)

    Hartmann, C., E-mail: Christoph.Hartmann@kit.edu [Karlsruhe Inst. of Tech. (KIT), Inst. for Neutron Physics and Reactor Technology (INR), Eggenstein-Leopoldshafen (Germany); Westinghouse Electric Germany GmbH, Mannheim (Germany); Sanchez, V.H. [Karlsruhe Inst. of Tech. (KIT), Inst. for Neutron Physics and Reactor Technology (INR), Eggenstein-Leopoldshafen (Germany); Tietsch, W. [Westinghouse Electric Germany GmbH, Mannheim (Germany)

    2011-07-01

    'Full text:' Coupled Thermal-hydraulic/Neutron-kinetic (TH/NK) simulations of Boiling Water Reactor transients require well validated and accurate simulation tools as well as appropriate cross sections (XS) libraries depending on the individual thermal hydraulic state parameters. Problem-dependent XS-sets for 3D core simulations are being generated mainly by well validated, fast running and user-friendly lattice codes such as Casco and Helios. At research institutions and universities, alternative tools to the commercial ones with full access to the source code as well as moderate cost are urgently needed. The Scale system is being developed and improved for lattice physics calculations of real core loading of Light Water Reactors (LWR). It represents a promising alternative to the commercial lattice codes. At Karlsruhe Institute of Technology (Kit) a computational route based on Scale/Triton/Newt for BWR core loading is under development. The generated XS-data sets have to be transformed in PMAXS-format for use in the reactor dynamic code PARCS. This task is performed by the module GenPMAXS being developed and tested at the Michigan University. To verify the computational route, a BWR fuel assembly depletion problem was calculated by PARCS and compared to the CASMO results. Since the SCALE/TRITON XS-file does actually not contain all required neutronic data, FORTRAN routines have been developed to incorporate the missing data e.g. the yields of Iodine, Xenon and Promethium into the XS-data sets in the PMAXS-format. The comparison of the results obtained with PARCS (using the corrected PMAXS file) and CASMO for the depletion problem exhibited a good agreement. Consequently, this approach was followed for the generation of a complete XS-set for a real BWR core to be used in subsequent transient analysis. Then 3D neutronic and thermal hydraulic core model were elaborated for a TRACE/PARCS analysis. The thermal hydraulic model is based on the 3D VESSEL

  15. Protocol for developing, disseminating and implementing a core outcome set for endometriosis

    Science.gov (United States)

    Hirsch, Martin; Duffy, James M N; Barker, Claire; Hummelshoj, Lone; Johnson, Neil P; Mol, Ben; Khan, Khalid S; Farquhar, Cindy

    2016-01-01

    Introduction Endometriosis is a common gynaecological disease characterised by pain and subfertility. Randomised controlled trials evaluating treatments for endometriosis have reported many different outcomes and outcome measures. This variation restricts effective data synthesis limiting the usefulness of research to inform clinical practice. To address these methodological concerns, we aim to develop, disseminate and implement a core outcome set for endometriosis engaging with key stakeholders, including healthcare professionals, researchers and women with endometriosis. Methods and analysis An international steering group has been established, including healthcare professionals, researchers and patient representatives. Potential outcomes identified from a systematic review of the literature will be entered into a modified Delphi method. Key stakeholders will be invited to participate including healthcare professionals, researchers and women with endometriosis. Participants will be invited to score individual outcomes on a nine-point Likert scale anchored between 1 (not important) and 9 (critical). Repeated reflection and rescoring should promote whole and individual stakeholder group converge towards consensus, ‘core’, outcomes. High-quality outcome measures will be associated with core outcomes. Ethics and dissemination The implementation of a core outcome set for endometriosis within future clinical trials, systematic reviews and clinical guidelines will enhance the availability of comparable data to facilitate evidence-based patient care. This study was prospectively registered with Core Outcome Measures in Effectiveness Trials Initiative; number: 691. PMID:28003300

  16. Composing a core set of performance indicators for public mental health care: a modified Delphi procedure.

    Science.gov (United States)

    Lauriks, Steve; de Wit, Matty A S; Buster, Marcel C A; Arah, Onyebuchi A; Klazinga, Niek S

    2014-09-01

    Public mental health care (PMHC) systems are responsible for the wellbeing of vulnerable groups that cope with complex psychosocial problems. This article describes the development of a set of performance indicators that are feasible, meaningful, and useful to assess the quality of the PMHC system in Amsterdam, the Netherlands. Performance indicators were selected from an international inventory and presented to stakeholders of the PMHC system in a modified Delphi procedure. Characteristics of indicators were judged individually, before consensus on a core set was reached during a plenary discussion. Involving stakeholders at early stages of development increases support for quality assessment.

  17. Preliminary safety analysis for key design features of KALIMER with breakeven core

    Energy Technology Data Exchange (ETDEWEB)

    Hahn, Do Hee; Kwon, Y. M.; Chang, W. P.; Suk, S. D.; Lee, Y. B.; Jeong, K. S

    2001-06-01

    KAERI is currently developing the conceptual design of a Liquid Metal Reactor, KALIMER (Korea Advanced Liquid MEtal Reactor) under the Long-term Nuclear R and D Program. KALIMER addresses key issues regarding future nuclear power plants such as plant safety, economics, proliferation, and waste. In this report, descriptions of safety design features and safety analyses results for selected ATWS accidents for the breakeven core KALIMER are presented. First, the basic approach to achieve the safety goal is introduced in Chapter 1, and the safety evaluation procedure for the KALIMER design is described in Chapter 2. It includes event selection, event categorization, description of design basis events, and beyond design basis events.In Chapter 3, results of inherent safety evaluations for the KALIMER conceptual design are presented. The KALIMER core and plant system are designed to assure benign performance during a selected set of events without either reactor control or protection system intervention. Safety analyses for the postulated anticipated transient without scram (ATWS) have been performed to investigate the KALIMER system response to the events. In Chapter 4, the design of the KALIMER containment dome and the results of its performance analyses are presented. The design of the existing containment and the KALIMER containment dome are compared in this chapter. Procedure of the containment performance analysis and the analysis results are described along with the accident scenario and source terms. Finally, a simple methodology is introduced to investigate the core energetics behavior during HCDA in Chapter 5. Sensitivity analyses have been performed for the KALIMER core behavior during super-prompt critical excursions, using mathematical formulations developed in the framework of the Modified Bethe-Tait method. Work energy potential was then calculated based on the isentropic fuel expansion model.

  18. Development of a Core Set from a Large Rice Collection using a Modified Heuristic Algorithm to Retain Maximum Diversity

    Institute of Scientific and Technical Information of China (English)

    Hun-Ki Chung; Kyu-Won Kim; Jong-Wook Chung; Jung-Ro Lee; Sok-Young Lee; Anupam Dixit; Hee-Kyoung Kang; Weiguo Zhao; Kenneth L. McNally; Ruraidh S. Hamilton; Jae-Gyun Gwag; Yong-Jin Park

    2009-01-01

    A new heuristic approach was undertaken for the establishment of a core set for the diversity research of rice. As a result,107 entries were selected from the 10 368 characterized accessions. The core set derived using this new approach provideda good representation of the characterized accessions present in the entire collection. No significant differences for the mean, range, standard deviation and coefficient of variation of each trait were observed between the core and existing collections. We also compared the diversity of core sets established using this Heuristic Core Collection (HCC) approach with those of core sets established using the conventional clustering methods. This modified heuristic algorithm can also be used to select genotype data with allelic richness and reduced redundancy, and to facilitate management and use of large collections of plant genetic resources in a more efficient way.

  19. Identification of the Core Set of Carbon-Associated Genes in a Bioenergy Grassland Soil

    Science.gov (United States)

    Howe, Adina; Yang, Fan; Williams, Ryan J.; Meyer, Folker; Hofmockel, Kirsten S.

    2016-01-01

    Despite the central role of soil microbial communities in global carbon (C) cycling, little is known about soil microbial community structure and even less about their metabolic pathways. Efforts to characterize soil communities often focus on identifying differences in gene content across environmental gradients, but an alternative question is what genes are similar in soils. These genes may indicate critical species or potential functions that are required in all soils. Here we identified the “core” set of C cycling sequences widely present in multiple soil metagenomes from a fertilized prairie (FP). Of 226,887 sequences associated with known enzymes involved in the synthesis, metabolism, and transport of carbohydrates, 843 were identified to be consistently prevalent across four replicate soil metagenomes. This core metagenome was functionally and taxonomically diverse, representing five enzyme classes and 99 enzyme families within the CAZy database. Though it only comprised 0.4% of all CAZy-associated genes identified in FP metagenomes, the core was found to be comprised of functions similar to those within cumulative soils. The FP CAZy-associated core sequences were present in multiple publicly available soil metagenomes and most similar to soils sharing geographic proximity. In soil ecosystems, where high diversity remains a key challenge for metagenomic investigations, these core genes represent a subset of critical functions necessary for carbohydrate metabolism, which can be targeted to evaluate important C fluxes in these and other similar soils. PMID:27855202

  20. Development of a Swedish Comprehensive International Classification of Functioning, Disability and Health (ICF) Core Set for adult patients with attention-deficit hyperactivity disorder (ADHD).

    Science.gov (United States)

    Söderström, Staffan; Pettersson, Richard; Edlund-Söderström, Kerstin; Ganse, Gunnar; Holmkvist, Eva; Westin, Olof; Haglund, Lena

    2014-04-01

    Attention-deficit hyperactivity disorder (ADHD) in adults is a phenomenon that attracts a lot of attention in society today. Advances in research have made it clear that many conditions that make people seek medical and psychiatric care may have pervasive deficits in attention, motor control and impulsivity at their roots. Since ADHD in adults is a relatively new and very versatile concept, there is a great need for systemized classification of the ramifications of the deficit that extends into every aspect of these patients' lives. To develop a Swedish Comprehensive International Classification of Functioning, Disability and Health (ICF) Core Set for adult patients with ADHD. A national expert survey was conducted using the Delphi technique and a formal consensus conference. Forty-two experts from different professions and organizations, including psychiatrists and physicians, psychologists, occupational therapists, a counsellor, a specialist nurse, representatives from a patient organization and representatives from the Swedish Social Insurance Agency, participated in the Delphi process and 28 participants from the expert group attended the consensus conference. At the formal consensus conference, 66 categories from the ICF were identified and included in the national Comprehensive Core Set for ADHD: 21 categories from the component body functions, 26 categories from the component activities and participation, and 19 categories from the component environmental factors. The Comprehensive Core Set for ADHD should be regarded as national and preliminary, and should be further tested and evaluated by experts in ADHD in clinical settings in Sweden.

  1. Overlap and Nonoverlap Between the ICF Core Sets for Hearing Loss and Otology and Audiology Intake Documentation.

    Science.gov (United States)

    van Leeuwen, Lisette M; Merkus, Paul; Pronk, Marieke; van der Torn, Marein; Maré, Marcel; Goverts, S Theo; Kramer, Sophia E

    The International Classification of Functioning Disability and Health (ICF) Core Sets for Hearing Loss (HL) were developed to serve as a standard for the assessment and reporting of the functioning and health of patients with HL. The aim of the present study was to compare the content of the intake documentation currently used in secondary and tertiary hearing care settings in the Netherlands with the content of the ICF Core Sets for HL. Research questions were (1) to what extent are the ICF Core Sets for HL represented in the Dutch Otology and Audiology intake documentation? (2) are there any extra ICF categories expressed in the intake documentation that are currently not part of the ICF Core Sets for HL, or constructs expressed that are not part of the ICF? Multicenter patient record study including 176 adult patients from two secondary, and two tertiary hearing care settings. The intake documentation was selected from anonymized patient records. The content was linked to the appropriate ICF category from the whole ICF classification using established linking rules. The extent to which the ICF Core Sets for HL were represented in the intake documentation was determined by assessing the overlap between the ICF categories in the Core Sets and the list of unique ICF categories extracted from the intake documentation. Any extra constructs that were expressed in the intake documentation but are not part of the Core Sets were described as well, differentiating between ICF categories that are not part of the Core Sets and constructs that are not part of the ICF classification. In total, otology and audiology intake documentation represented 24 of the 27 Brief ICF Core Set categories (i.e., 89%), and 60 of the 117 Comprehensive ICF Core Set categories (i.e., 51%). Various ICF Core Sets categories were not represented, including higher mental functions (Body Functions), civic life aspects (Activities and Participation), and support and attitudes of family (Environmental

  2. Reliability and Practicality of the Core Score: Four Dynamic Core Stability Tests Performed in a Physician Office Setting.

    Science.gov (United States)

    Friedrich, Jason; Brakke, Rachel; Akuthota, Venu; Sullivan, William

    2017-07-01

    Pilot study to determine the practicality and inter-rater reliability of the "Core Score," a composite measure of 4 clinical core stability tests. Repeated measures. Academic hospital physician clinic. 23 healthy volunteers with mean age of 32 years (12 females, 11 males). All subjects performed 4 core stability maneuvers under direct observation from 3 independent physicians in sequence. Inter-rater reliability and time necessary to perform examination. The Core Score scale is 0 to 12, with 12 reflecting the best core stability. The mean composite score of all 4 tests for all subjects was 9.54 (SD, 1.897; range, 4-12). The intraclass correlation coefficients (ICC 1,1) for inter-rater reliability for the composite Core Score and 4 individual tests were 0.68 (Core Score), 0.14 (single-leg squat), 0.40 (supine bridge), 0.69 (side bridge), and 0.46 (prone bridge). The time required for a single examiner to assess a given subject's core stability in all 4 maneuvers averaged 4 minutes (range, 2-6 minutes). Even without specialized equipment, a clinically practical and moderately reliable measure of core stability may be possible. Further research is necessary to optimize this measure for clinical application. Despite the known value of core stability to athletes and patients with low back pain, there is currently no reliable and practical means for rating core stability in a typical office-based practice. This pilot study provides a starting point for future reliability research on clinical core stability assessments.

  3. International Spinal Cord Injury Core Data Set (version 2.0)-including standardization of reporting.

    Science.gov (United States)

    Biering-Sørensen, F; DeVivo, M J; Charlifue, S; Chen, Y; New, P W; Noonan, V; Post, M W M; Vogel, L

    2017-08-01

    The study design includes expert opinion, feedback, revisions and final consensus. The objective of the study was to present the new knowledge obtained since the International Spinal Cord Injury (SCI) Core Data Set (Version 1.0) published in 2006, and describe the adjustments made in Version 2.0, including standardization of data reporting. International. Comments received from the SCI community were discussed in a working group (WG); suggestions from the WG were reviewed and revisions were made. All suggested revisions were considered, and a final version was circulated for final approval. The International SCI Core Data Set (Version 2.0) consists of 25 variables. Changes made to this version include the deletion of one variable 'Total Days Hospitalized' and addition of two variables 'Date of Rehabilitation Admission' and 'Date of Death.' The variable 'Injury Etiology' was extended with six non-traumatic categories, and corresponding 'Date of Injury' for non-traumatic cases, was defined as the date of first physician visit for symptoms related to spinal cord dysfunction. A category reflecting transgender was added. A response category was added to the variable on utilization of ventilatory assistance to document the use of continuous positive airway pressure for sleep apnea. Other clarifications were made to the text. The reporting of the pediatric SCI population was updated as age groups 0-5, 6-12, 13-14, 15-17 and 18-21. Collection of the core data set should be a basic requirement of all studies of SCI to facilitate accurate descriptions of patient populations and comparison of results across published studies from around the world.

  4. Do ICF core sets for low back pain include patients' self-reported activity limitations because of back problems?

    Science.gov (United States)

    Lygren, Hildegunn; Strand, Liv Inger; Anderson, Bodil; Magnussen, Liv Heide

    2014-06-01

    The aim of this study was to investigate content validity of the International Classification of Functioning, Disability and Health (ICF) Core Sets for low back pain (LBP), by examining whether common activities reported as difficult to perform are included in the Core Sets. A cross-sectional design was used. Ninety-eight patients with long-lasting back pain (>3 months) between 18 and 65 years of age were consecutively recruited from a Multidisciplinary Outpatient Spine Clinic. Difficulties with daily life and work task activities because of back pain were examined by asking the patients two questions: 1) can you specify activities that are difficult to perform because of your back pain? and 2) are there specific work tasks that you are unable to do because of your back pain? Two raters independently classified the written responses according to the ICF Core Sets' component Activities and Participation. Activities and work tasks were linked to 15 of 29 categories (52%) in the Comprehensive Core Set, and 9 of 12 (75%) in the Brief Core Set, and the initial agreement between the two raters in coding the answers according to the Core Sets was (83%, k = 0.80) and (93%, k = 0.9), respectively, before consensus was reached. The Comprehensive Core Set for LBP to a large degree contains daily life and work-related activities frequently reported as difficult to perform by patients with long-lasting LBP. The categories, however, are very broad and do not provide specified descriptions of the most frequently reported activity limitations such as sitting, standing and walking. The Brief Core Set does not include categories for frequently reported activities such as pulling/pushing and leisure/recreation activities. ICF Core Sets for LBP seem suitable for obtaining a gross overview of the patients' functional limitations, but do not give sufficient information from a therapeutic point of view. © 2013 John Wiley & Sons, Ltd.

  5. Improving decision making for massive transfusions in a resource poor setting: a preliminary study in Kenya.

    Directory of Open Access Journals (Sweden)

    Elisabeth D Riviello

    Full Text Available The reality of finite resources has a real-world impact on a patient's ability to receive life-saving care in resource-poor settings. Blood for transfusion is an example of a scarce resource. Very few studies have looked at predictors of survival in patients requiring massive transfusion. We used data from a rural hospital in Kenya to develop a prediction model of survival among patients receiving massive transfusion.Patients who received five or more units of whole blood within 48 hours between 2004 and 2010 were identified from a blood registry in a rural hospital in Kenya. Presenting characteristics and in-hospital survival were collected from charts. Using stepwise selection, a logistic model was developed to predict who would survive with massive transfusion versus those who would die despite transfusion. An ROC curve was created from this model to quantify its predictive power.Ninety-five patients with data available met inclusion criteria, and 74% survived to discharge. The number of units transfused was not a predictor of mortality, and no threshold for futility could be identified. Preliminary results suggest that initial blood pressure, lack of comorbidities, and indication for transfusion are the most important predictors of survival. The ROC curve derived from our model demonstrates an area under the curve (AUC equal to 0.757, with optimism of 0.023 based on a bootstrap validation.This study provides a framework for making prioritization decisions for the use of whole blood in the setting of massive bleeding. Our analysis demonstrated an overall survival rate for patients receiving massive transfusion that was higher than clinical perception. Our analysis also produced a preliminary model to predict survival in patients with massive bleeding. Prediction analyses can contribute to more efficient prioritization decisions; these decisions must also include other considerations such as equity, acceptability, affordability and

  6. Identification of a core set of genes that signifies pathways underlying cardiac hypertrophy

    DEFF Research Database (Denmark)

    Strom, C.C.; Kruhoffer, M.; Knudsen, Steen

    2004-01-01

    Although the molecular signals underlying cardiac hypertrophy have been the subject of intense investigation, the extent of common and distinct gene regulation between different forms of cardiac hypertrophy remains unclear. We hypothesized that a general and comparative analysis of hypertrophic...... gene expression, using microarray technology in multiple models of cardiac hypertrophy, including aortic banding, myocardial infarction, an arteriovenous shunt and pharmacologically induced hypertrophy, would uncover networks of conserved hypertrophy-specific genes and identify novel genes involved...... in hypertrophic signalling. From gene expression analyses (8740 probe sets, n = 46) of rat ventricular RNA, we identified a core set of 139 genes with consistent differential expression in all hypertrophy models as compared to their controls, including 78 genes not previously associated with hypertrophy and 61...

  7. The Core Mouse Response to Infection by Neospora Caninum Defined by Gene Set Enrichment Analyses

    Science.gov (United States)

    Ellis, John; Goodswen, Stephen; Kennedy, Paul J; Bush, Stephen

    2012-01-01

    In this study, the BALB/c and Qs mouse responses to infection by the parasite Neospora caninum were investigated in order to identify host response mechanisms. Investigation was done using gene set (enrichment) analyses of microarray data. GSEA, MANOVA, Romer, subGSE and SAM-GS were used to study the contrasts Neospora strain type, Mouse type (BALB/c and Qs) and time post infection (6 hours post infection and 10 days post infection). The analyses show that the major signal in the core mouse response to infection is from time post infection and can be defined by gene ontology terms Protein Kinase Activity, Cell Proliferation and Transcription Initiation. Several terms linked to signaling, morphogenesis, response and fat metabolism were also identified. At 10 days post infection, genes associated with fatty acid metabolism were identified as up regulated in expression. The value of gene set (enrichment) analyses in the analysis of microarray data is discussed. PMID:23012496

  8. Identification of a core set of genes that signifies pathways underlying cardiac hypertrophy

    DEFF Research Database (Denmark)

    Strøm, Claes C; Kruhøffer, Mogens; Knudsen, Steen

    2004-01-01

    Although the molecular signals underlying cardiac hypertrophy have been the subject of intense investigation, the extent of common and distinct gene regulation between different forms of cardiac hypertrophy remains unclear. We hypothesized that a general and comparative analysis of hypertrophic...... gene expression, using microarray technology in multiple models of cardiac hypertrophy, including aortic banding, myocardial infarction, an arteriovenous shunt and pharmacologically induced hypertrophy, would uncover networks of conserved hypertrophy-specific genes and identify novel genes involved...... in hypertrophic signalling. From gene expression analyses (8740 probe sets, n = 46) of rat ventricular RNA, we identified a core set of 139 genes with consistent differential expression in all hypertrophy models as compared to their controls, including 78 genes not previously associated with hypertrophy and 61...

  9. First-Line Use of Core Needle Biopsy for High-Yield Preliminary Diagnosis of Thyroid Nodules.

    Science.gov (United States)

    Kim, H C; Kim, Y J; Han, H Y; Yi, J M; Baek, J H; Park, S Y; Seo, J Y; Kim, K W

    2017-02-01

    Although core needle biopsy was introduced as a diagnostic alternative to fine-needle aspiration, the utility and safety of core needle biopsy for thyroid nodules in a large population has yet to be studied comprehensively. We evaluate core needle biopsy yields on a large-scale basis to investigate its potential in the preliminary diagnosis of thyroid nodules. Between March 2005 and December 2013, 2448 initially detected thyroid nodules from 2120 consecutive patients who underwent core needle biopsy were retrospectively evaluated. Of these, 72 thyroid nodules from 63 patients were excluded due to prior fine-needle aspiration attempts. The inconclusive and conclusive result rates, diagnostic accuracy, sensitivity, specificity, positive predictive value, negative predictive value, and unnecessary surgery rate of core needle biopsy were evaluated. With core needle biopsy as the first-line method, the inconclusive result rate was 11.9% (283/2376) and the conclusive result rate was 88.1% (2093/2376). The diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of core needle biopsy for the diagnosis of malignancy were 96.7% (1160/1200), 89.7% (347/387), 100% (813/813), 100% (347/347), and 95.3% (813/853), respectively. There were no major complications and 12 minor complications. We have demonstrated that first-line use of core needle biopsy may well improve diagnostic accuracy in thyroid nodules, reducing inconclusive or false-negative results and unnecessary operations. Such benefits underscore the promising role of core needle biopsy in managing thyroid nodules and optimizing related surgical decision-making. © 2017 by American Journal of Neuroradiology.

  10. Towards an ICF core set for ADHD: a worldwide expert survey on ability and disability.

    Science.gov (United States)

    de Schipper, Elles; Mahdi, Soheil; Coghill, David; de Vries, Petrus J; Gau, Susan Shur-Fen; Granlund, Mats; Holtmann, Martin; Karande, Sunil; Levy, Florence; Almodayfer, Omar; Rohde, Luis; Tannock, Rosemary; Bölte, Sven

    2015-12-01

    This is the second in a series of four empirical studies designed to develop International Classification of Functioning, Disability and Health (ICF and Children and Youth version, ICF-CY) core sets for attention deficit hyperactivity disorder (ADHD). The objective of this stage was to gather the opinions from international experts on which ability and disability concepts were considered relevant to functioning in ADHD. An email-based survey was carried out amongst international experts in ADHD. Relevant functional ability and disability concepts were extracted from their responses and linked to the ICF/-CY categories by two independent researchers using a standardised linking procedure. 174 experts from 11 different disciplines and 45 different countries completed the survey. Meaningful concepts identified in their responses were linked to 185 ICF/-CY categories. Of these, 83 categories were identified by at least 5 % of the experts and considered the most relevant to ADHD: 30 of these were related to Body functions (most identified: attention functions, 85 %), 30 to Activities and Participation (most identified: school education, 52 %), 20 to Environmental factors (most identified: support from immediate family, 61 %), and 3 to Body structures (most identified: structure of brain, 83 %). Experts also provided their views on particular abilities related to ADHD, naming characteristics such as high-energy levels, flexibility and resiliency. Gender differences in the expression of ADHD identified by experts pertained mainly to females showing more internalising (e.g. anxiety, low self-esteem) and less externalising behaviours (e.g. hyperactivity), leading to a risk of late- and under-diagnosis in females. Results indicate that the impact of ADHD extends beyond the core symptom domains, into all areas of life and across the lifespan. The current study in combination with three additional preparatory studies (comprehensive scoping review, focus groups, clinical study

  11. International Classification of Functioning, Disability and Health (ICF) Core Set for patients with vertigo, dizziness and balance disorders.

    Science.gov (United States)

    Grill, Eva; Bronstein, Adolfo; Furman, Joseph; Zee, David S; Müller, Martin

    2012-01-01

    Vertigo, dizziness and balance disorders have major impact on independence, employability, activities and participation. There are many measures for the assessment of the impact of vertigo, but no consensus exists on which aspects should be measured. The objective of this study was to develop international standards (ICF Core Sets) for patients with vertigo and dizziness to describe functioning. The development of the ICF Core Sets involved a formal decision-making and consensus process, integrating evidence from preparatory studies including qualitative interviews with patients, a systematic review of the literature, a survey with health professionals, and empirical data collection from patients. Twenty-seven experts selected 100 second level categories for the comprehensive Core Set and 29 second level categories for the Brief Core Set. The largest number of categories was selected from the ICF component Activities and Participation (40). Twenty-five categories were selected from the component Body Functions, six from Body Structures, and 29 from Environmental Factors. The ICF Core Set for vertigo is designed for physicians, nurses, therapists and other health professionals working in inpatient or ambulatory settings. ICF Core Sets create patient-relevant outcomes that can be used as evidence for the success of treatments.

  12. An Algorithm for Glaucoma Screening in Clinical Settings and Its Preliminary Performance Profile

    Directory of Open Access Journals (Sweden)

    S-Farzad Mohammadi

    2013-01-01

    Full Text Available Purpose: To devise and evaluate a screening algorithm for glaucoma in clinical settings. Methods: Screening included examination of the optic disc for vertical cupping (≥0.4 and asymmetry (≥0.15, Goldmann applanation tonometry (≥21 mmHg, adjusted or unadjusted for central corneal thickness, and automated perimetry. In the diagnostic step, retinal nerve fiber layer imaging was performed using scanning laser polarimetry. Performance of the screening protocol was assessed in an eye hospital-based program in which 124 non-physician personnel aged 40 years or above were examined. A single ophthalmologist carried out the examinations and in equivocal cases, a glaucoma subspecialist′s opinion was sought. Results: Glaucoma was diagnosed in six cases (prevalence 4.8%; 95% confidence interval, 0.01-0.09 of whom five were new. The likelihood of making a definite diagnosis of glaucoma for those who were screened positively was 8.5 times higher than the estimated baseline risk for the reference population; the positive predictive value of the screening protocol was 30%. Screening excluded 80% of the initial population. Conclusion: Application of a formal screening protocol (such as our algorithm or its equivalent in clinical settings can be helpful in detecting new cases of glaucoma. Preliminary performance assessment of the algorithm showed its applicability and effectiveness in detecting glaucoma among subjects without any visual complaint.

  13. Preliminary criteria for the very early diagnosis of systemic sclerosis

    DEFF Research Database (Denmark)

    Avouac, J; Fransen, Julie Munk; Walker, U A

    2011-01-01

    To identify a core set of preliminary items considered as important for the very early diagnosis of systemic sclerosis (SSc).......To identify a core set of preliminary items considered as important for the very early diagnosis of systemic sclerosis (SSc)....

  14. Reliability, construct validity and measurement potential of the ICF comprehensive core set for osteoarthritis

    Directory of Open Access Journals (Sweden)

    Kurtaiş Yeşim

    2011-11-01

    Full Text Available Abstract Background This study aimed to investigate the reliability and construct validity of the International Classification of Functioning, Disability and Health (ICF Comprehensive Core Set for osteoarthritis (OA in order to test its possible use as a measuring tool for functioning. Methods 100 patients with OA (84 F, 16 M; mean age 63 yr completed forms including demographic and clinical information besides the Short Form (36 Health Survey (SF-36® and the Western Ontario and McMaster Universities Index of Osteoarthritis (WOMAC. The ICF Comprehensive Core Set for OA was filled by health professionals. The internal construct validities of "Body Functions-Body structures" (BF-BS, "Activity" (A, "Participation" (P and "Environmental Factors" (EF domains were tested by Rasch analysis and reliability by internal consistency and person separation index (PSI. External construct validity was evaluated by correlating the Rasch transformed scores with SF-36 and WOMAC. Results In each scale, some items showing disordered thresholds were rescored, testlets were created to overcome the problem of local dependency and items that did not fit to the Rasch model were deleted. The internal construct validity of the four scales (BF-BS 16 items, A 8 items, P 7 items, EF 13 items were good [mean item fit (SD 0.138 (0.921, 0.216 (1.237, 0.759 (0.986 and -0.079 (2.200; person item fit (SD -0.147 (0.652, -0.241 (0.894, -0.310 (1.187 and -0.491 (1.173 respectively], indicating a single underlying construct for each scale. The scales were free of differential item functioning (DIF for age, gender, years of education and duration of disease. Reliabilities of the BF-BS, A, P, and EF scales were good with Cronbach's alphas of 0.79, 0.86, 0.88, and 0.83 and PSI's of 0.76, 0.86, 0.87, and 0.71, respectively. Rasch scores of BF-BS, A, and P showed moderate correlations with SF-36 and WOMAC scores where the EF had significant but weak correlations only with SF36-Social

  15. Proposal for a Candidate Core Set of Fitness and Strength Tests for Patients with Childhood or Adult Idiopathic Inflammatory Myopathies.

    Science.gov (United States)

    van der Stap, Djamilla K D; Rider, Lisa G; Alexanderson, Helene; Huber, Adam M; Gualano, Bruno; Gordon, Patrick; van der Net, Janjaap; Mathiesen, Pernille; Johnson, Liam G; Ernste, Floranne C; Feldman, Brian M; Houghton, Kristin M; Singh-Grewal, Davinder; Kutzbach, Abraham Garcia; Alemo Munters, Li; Takken, Tim

    2016-01-01

    Currently there are no evidence-based recommendations regarding fitness and strength tests for patients with childhood or adult idiopathic inflammatory myopathies (IIM). This hinders clinicians and researchers in choosing the appropriate fitness- or muscle strength-related outcome measures for these patients. Through a Delphi survey, we aimed to identify a candidate core set of fitness and strength tests for children and adults with IIM. Fifteen experts participated in a Delphi survey that consisted of 5 stages to achieve a consensus. Using an extensive search of published literature and through the work of experts, a candidate core set based on expert opinion and clinimetrics properties was developed. Members of the International Myositis Assessment and Clinical Studies Group were invited to review this candidate core set during the final stage, which led to a final candidate core set. A core set of fitness- and strength-related outcome measures was identified for children and adults with IIM. For both children and adults, different tests were identified and selected for maximal aerobic fitness, submaximal aerobic fitness, anaerobic fitness, muscle strength tests, and muscle function tests. The core set of fitness- and strength-related outcome measures provided by this expert consensus process will assist practitioners and researchers in deciding which tests to use in patients with IIM. This will improve the uniformity of fitness and strength tests across studies, thereby facilitating the comparison of study results and therapeutic exercise program outcomes among patients with IIM.

  16. Core gene set as the basis of multilocus sequence analysis of the subclass Actinobacteridae.

    Directory of Open Access Journals (Sweden)

    Toïdi Adékambi

    Full Text Available Comparative genomic sequencing is shedding new light on bacterial identification, taxonomy and phylogeny. An in silico assessment of a core gene set necessary for cellular functioning was made to determine a consensus set of genes that would be useful for the identification, taxonomy and phylogeny of the species belonging to the subclass Actinobacteridae which contained two orders Actinomycetales and Bifidobacteriales. The subclass Actinobacteridae comprised about 85% of the actinobacteria families. The following recommended criteria were used to establish a comprehensive gene set; the gene should (i be long enough to contain phylogenetically useful information, (ii not be subject to horizontal gene transfer, (iii be a single copy (iv have at least two regions sufficiently conserved that allow the design of amplification and sequencing primers and (v predict whole-genome relationships. We applied these constraints to 50 different Actinobacteridae genomes and made 1,224 pairwise comparisons of the genome conserved regions and gene fragments obtained by using Sequence VARiability Analysis Program (SVARAP, which allow designing the primers. Following a comparative statistical modeling phase, 3 gene fragments were selected, ychF, rpoB, and secY with R2>0.85. Selected sets of broad range primers were tested from the 3 gene fragments and were demonstrated to be useful for amplification and sequencing of 25 species belonging to 9 genera of Actinobacteridae. The intraspecies similarities were 96.3-100% for ychF, 97.8-100% for rpoB and 96.9-100% for secY among 73 strains belonging to 15 species of the subclass Actinobacteridae compare to 99.4-100% for 16S rRNA. The phylogenetic topology obtained from the combined datasets ychF+rpoB+secY was globally similar to that inferred from the 16S rRNA but with higher confidence. It was concluded that multi-locus sequence analysis using core gene set might represent the first consensus and valid approach for

  17. Protocol for the development of a core domain set for hidradenitis suppurativa trial outcomes

    DEFF Research Database (Denmark)

    Thorlacius, Linnea; Ingram, John R; Garg, Amit

    2017-01-01

    Delphi rounds are then planned together with 2 face-to-face consensus meetings (1 in Europe and 1 in the USA) to ensure global representation. ETHICS AND DISSEMINATION: The study will be performed according to the Helsinki declaration. All results from the study, including inconclusive or negative...... for dealing with these problems is to develop a core outcome set (COS). A COS is a list of outcomes that are meant as mandatory and should be measured and reported in all clinical trials. The aim of this study is to develop a COS for the management of HS. METHOD AND ANALYSIS: An international steering group...... of researchers, clinicians and a patient research partner will guide the COS development. 6 stakeholder groups are involved: patients, dermatologists, surgeons, nurses, industry representatives and drug regulatory authorities. A 1:1 ratio of patients:healthcare professionals is aimed for. The initial list...

  18. Validation of the comprehensive ICF core sets for diabetes mellitus:a Malaysian perspective.

    Science.gov (United States)

    Abdullah, Mohd Faudzi; Nor, Norsiah Mohd; Mohd Ali, Siti Zubaidah; Ismail Bukhary, Norizzati Bukhary; Amat, Azlin; Latif, Lydia Abdul; Hasnan, Nazirah; Omar, Zaliha

    2011-04-01

    Diabetes mellitus (DM) is a chronic disease that is prevalent in many countries. The prevalence of DM is on the rise, and its complications pose a heavy burden on the healthcare systems and on the patients' quality of life worldwide. This is a multicentre, cross-sectional study involving 5 Health Clinics conducted by Family Medicine Specialists in Malaysia. Convenience sampling of 100 respondents with DM were selected. The International Classifi cation of Functioning, Disability and Health (ICF) based measures were collected using the Comprehensive Core Set for DM. SF-36 and self-administered forms and comorbidity questionnaire (SCQ) were also used. Ninety-seven percent had Type 2 DM and 3% had Type 1 DM. The mean period of having DM was 6 years. Body functions related to physical health including exercise tolerance (b455), general physical endurance (b4550), aerobic capacity (b4551) and fatiguability (b4552) were the most affected. For body structures, the structure of pancreas (s550) was the most affected. In the ICF component of activities and participation, limitation in sports (d9201) was the highest most affected followed by driving (d475), intimate relationships (d770), handling stress and other psychological demands (d240) and moving around (d455). Only 7% (e355 and e450) in the environmental category were documented as being a relevant factor by more than 90% of the patients. The content validity of the comprehensive ICF Core set DM for Malaysian population were identified and the results show that physical and mental functioning were impaired in contrast to what the respondents perceived as leading healthy lifestyles.

  19. Validation of the "Activity and participation" component of ICF Core Sets for stroke patients in Japanese rehabilitation wards

    Science.gov (United States)

    Kinoshita, Shoji; Abo, Masahiro; Miyamura, Kohei; Okamoto, Takatsugu; Kakuda, Wataru; Kimura, Ikuo; Urabe, Hiroshi

    2016-10-12

    To validate the International Classification of Functioning, Disability and Health (ICF) Core Set for stroke in the assessment of functional status and disability in Japanese stroke patients. The study included stroke patients admitted to the Kaifukuki (convalescent) rehabilitation wards. The comprehensive ICF Core Set for neurological conditions for post-acute care and the ICF rehabilitation set were evaluated with qualifiers assessed by the physiatrists at admission. The "activity and participation" (d) component was divided to sub-components (cognition-related activity, motor-related activity and participation). The correlations between numbers of problem categories in the entire "d" component and these sub-components in each ICF Core Set and the Functional Independence Measure (FIM) score were assessed using Spearman's correlation coefficient. A total of 117 post-stroke patients (mean age 70.1 ± 14.2 years, 53 women) were included. Correlation analysis identified significant and strong correlations between the values of the entire "d" component and sub-components (cognition-related activity and motor-related activity) of the 2 ICF Core Sets and FIM score. A significant, but weak, correlation between FIM and the participation sub-component was identified. The "d" component of these 2 ICF Core Sets reflects functional status and disability and could be a valid measure in post-acute stroke patients in the rehabilitation setting.

  20. New large solar photocatalytic plant: set-up and preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Malato, S.; Blanco, J.; Vidal, A.; Fernandez, P.; Caceres, J. [Plataforma Solar de Almeria (Spain); Trincado, P. [HIDROCEN, Madrid (Spain); Oliveira, J.C. [AOSOL, Samora-Corria (Portugal); Vincent, M. [ECOSYSTEM S.A., Barcelona (Spain)

    2002-04-01

    A European industrial consortium called SOLARDETOX has been created as the result of an EC-DGXII BRITE-EURAM-III-financed project on solar photocatalytic detoxification of water. The project objective was to develop a simple, efficient and commercially competitive water-treatment technology, based on compound parabolic collectors (CPCs) solar collectors and TiO{sub 2} photocatalysis, to make possible easy design and installation. The design, set-up and preliminary results of the main project deliverable, the first European industrial solar detoxification treatment plant, is presented. This plant has been designed for the batch treatment of 2 m{sup 3} of water with a 100 m{sup 2} collector-aperture area and aqueous aerated suspensions of polycrystalline TiO{sub 2} irradiated by sunlight. Fully automatic control reduces operation and maintenance manpower. Plant behaviour has been compared (using dichloroacetic acid and cyanide at 50 mgl{sup -1} initial concentration as model compounds) with the small CPC pilot plants installed at the Plataforma Solar de Almeria several years ago. The first results with high-content cyanide (1 gl{sup -1}) waste water are presented and plant treatment capacity is calculated. (author)

  1. Set-up and preliminary performance of a digital radiology conference system

    Institute of Scientific and Technical Information of China (English)

    王学建; 胡建; 曹军; 王波; 焦俊; 魏渝清; 王小林; 罗敏; 罗松

    2003-01-01

    Objective To investigate the set-up and preliminary performance of a digital radiology conference system and its characteristics. Methods The imaging system included a dual-screen image-text workstation with a Matrox G450 demonstration dual-head card, two multimedia projectors, a large screen, and a line-pair and grey scale test card. Patient information on radiology information system (RIS) and images on picture archiving and communication system (PACS) were fetched with GE Radworks software based on Intranet and PACS. The fetching velocity and resolution and grey scale of the images were measured. Results Patient information in the form of texts and images were demonstrated successfully on two screens with Matrox G450 demonstration dual-head card and switched rapidly between text-image two-screen and image two-screen. The image fetching velocity was fast, the resolution was high, and the grey scale was good. Conclusion The digital conference radiology system is good, and should be popularized.

  2. Offending by people with intellectual disabilities in community settings: a preliminary examination of contextual factors.

    Science.gov (United States)

    Wheeler, Jessica R; Clare, Isabel C H; Holland, Anthony J

    2013-09-01

    While several validated measures of the life circumstances of people with intellectual disabilities (ID) have been developed, this stream of research has not yet been well integrated with environmentally oriented criminological theory to explain offending among people with ID. In this study, we attempt to provide a preliminary integration through an investigation of the relationship between contemporary life experiences, well-being, choice and offending among people with ID, exploring the relevance of two classic criminological theories (theories of strain and social control). Questionnaire measures were used to compare a range of 'ordinary' life experiences [the 'Life Experiences Checklist' (LEC)], subjective well-being (the 'Personal Well-being Index - ID') and the extent of choice (the 'Choice Questionnaire'), between offenders (N = 27) and non-offenders (N = 19) with ID recruited through integrated (NHS and Local Authority) multi-disciplinary teams (community teams for adults with learning disabilities). Using regression analyses to explore the strength of associations with offending, it was found that an indicator of impoverished personal relationships, from the LEC provided the best predictor of offending. This finding appears to favour criminological explanations based on social control. Existing measures of life circumstances can be used to explore environmentally oriented criminological theories, bringing benefits to our understanding and treatment of offenders with ID living in community settings. © 2013 John Wiley & Sons Ltd.

  3. Setting up and functioning of an Emergency Medicine Department: Lessons learned from a preliminary study

    Directory of Open Access Journals (Sweden)

    K Asish

    2016-01-01

    Full Text Available Background and Aims: Tertiary care teaching hospitals remain referral centres for victims of trauma and mass casualty. Often specialists from various disciplines manage these crowded casualty areas. These age old casualty areas are being replaced, throughout the country by Emergency Medicine Departments (EMDs, presumed to be better planned to confront a crisis. We aimed to gather basic data contributive in setting up of an EMD at a tertiary care teaching hospital from the lessons learned from functioning existent systems. Methods: This is primarily a questionnaire-based descriptive study at tertiary care referral centres across the country, which was purposively selected.The study models included one from a hospital without designated EMD and the other four from hospitals with established EMDs. Direct observation and focus group meetings with experienced informants at these hospitals contributed to the data. In the absence of a validated hospital preparedness assessment scale, comparison was done with regard to quantitative, qualitative and corroborative parameters using descriptive analysis. Results: The EMDs at best practice models were headed by specialist in Emergency Medicine assisted by organised staff, had protocols for managing mass casualty incident (MCI, separate trauma teams, ergonomic use of infrastructure and public education programmes. In this regard, these hospitals seemed well organised to manage MCIs and disasters. Conclusion: The observation may provide a preliminary data useful in setting up an EMD. In the absence of published Indian literature, this may facilitate further research in this direction. Anaesthesiologists, presently an approved Faculty in Emergency Medicine training can provide creative input with regard to its initial organisation and functioning, thus widening our horizons in a country where there is a severe dearth of trained emergency physicians.

  4. Toolbox of multiple-item measures aligning with the ICF Core Sets for children and youth with cerebral palsy.

    Science.gov (United States)

    Schiariti, Verónica; Tatla, Sandy; Sauve, Karen; O'Donnell, Maureen

    2017-03-01

    Selecting appropriate measure(s) for clinical and/or research applications for children and youth with Cerebral Palsy (CP) poses many challenges. The newly developed International Classification of Functioning, Disability and Health (ICF) Core Sets for children and youth with CP serve as universal guidelines for assessment, intervention and follow-up. The aims of this study were: 1) to identify valid and reliable measures used in studies with children and youth with CP, 2) to characterize the content of each measure using the ICF Core Sets for children and youth with CP as a framework, and finally 3) to create a toolbox of psychometrically sound measures covering the content of each ICF Core Set for children and youth with CP. All clearly defined multiple-item measures used in studies with CP between 1998 and 2015 were identified. Psychometric properties were extracted when available. Construct of the measures were linked to the ICF Core Sets. Overall, 83 multiple-item measures were identified. Of these, 68 measures (80%) included reliability and validity testing. The majority of the measures were discriminative, generic and designed for school-aged children. The degree to which measures with proven psychometric properties represented the ICF Core Sets for children and youth with CP varied considerably. Finally, 25 valid and reliable measures aligned highly with the content of the ICF Core Sets, and as such, these measures are proposed as a novel ICF Core Sets-based toolbox of measures for CP. Our results will guide professionals seeking appropriate measures to meet their research and clinical needs worldwide. Copyright © 2016 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

  5. Content Validity of the Comprehensive ICF Core Set for Multiple Sclerosis from the Perspective of Speech and Language Therapists

    Science.gov (United States)

    Renom, Marta; Conrad, Andrea; Bascuñana, Helena; Cieza, Alarcos; Galán, Ingrid; Kesselring, Jürg; Coenen, Michaela

    2014-01-01

    Background: The Comprehensive International Classification of Functioning, Disability and Health (ICF) Core Set for Multiple Sclerosis (MS) is a comprehensive framework to structure the information obtained in multidisciplinary clinical settings according to the biopsychosocial perspective of the International Classification of Functioning,…

  6. Content Validity of the Comprehensive ICF Core Set for Multiple Sclerosis from the Perspective of Speech and Language Therapists

    Science.gov (United States)

    Renom, Marta; Conrad, Andrea; Bascuñana, Helena; Cieza, Alarcos; Galán, Ingrid; Kesselring, Jürg; Coenen, Michaela

    2014-01-01

    Background: The Comprehensive International Classification of Functioning, Disability and Health (ICF) Core Set for Multiple Sclerosis (MS) is a comprehensive framework to structure the information obtained in multidisciplinary clinical settings according to the biopsychosocial perspective of the International Classification of Functioning,…

  7. Preliminary study of degradation from neutron effects of core-structural materials of Thai Research Reactor TRR-1/M1

    Science.gov (United States)

    Ampornrat, P.; Boonsuwan, P.; Sangkaew, S.; Angwongtrakool, T.

    2017-06-01

    Thai research reactor went first critical in 1962. The reactor was converted in 1977 from an MTR-type with high-enriched uranium fuel to a TRIGA-MARK III type using low-enriched uranium fuel, called TRR-1/M1. Since the TRR-1/M1 has been operated for almost 40 years, degradation of reactor structural materials is expected. In this preliminary study, the potential degradation from neutron effects of core-structural materials, e.g., fuel clad (SS304) and core components (Al6061) were studied. Assessment included calculation of neutron energy, flux and fluence in the reactor core to evaluate displacement rate (dpa) and irradiation effects on the material properties. Results showed maximum displacement rates on SS304 was 5.24×10-8 per cm3·sec and on Al6061 was 1.14×10-8 per cm3·sec. The corresponding maximum displacement levels were ∼17 dpa for SS304, and ∼4 dpa for Al6061. At these levels of displacement, it is possible for the materials to result in tensile strength increasing and ductility reduction. Further inspection on the core-structural materials needs to be conducted to validate the assessment results from this study.

  8. A Preliminary Paleomagnetic Rsult of Quaternary Drilling Core form Southern Leizhou Peninsula,Guangdong Province

    Institute of Scientific and Technical Information of China (English)

    王俊达; 梁池生; 等

    1999-01-01

    313 orientated samples were collected from Drilling Core ZK1 in southern Leizhou Peninsula for the study of Quaternary paleomagnetic strato-chronology.Te polarity measurement results indicate that the core recorded paleomagnetic information in three main parts:the upper one of the core,from the ground surface to the depth of 39m ,is normally magnetized in polarity,the middle one,from 39m 59 210m in depth,mainly shows reversed polarity and the lower one recorded normal polarity again.They correspond to the Brunhes normal chron,the Matuyama reversed chron and the Guass normal chron in the geomagnetic polarity time scale,respectively.The age of he core could be over 3.4Ma.Meanwhile,the magnetic susceptibility was measured and its result is significant for stratigraphic division and paleoclimatic research.

  9. Validation of the Comprehensive ICF Core Set for Vocational Rehabilitation From the Perspective of Physical Therapists: International Delphi Survey.

    Science.gov (United States)

    Kaech Moll, Veronika M; Escorpizo, Reuben; Portmann Bergamaschi, Ruth; Finger, Monika E

    2016-08-01

    The Comprehensive ICF Core Set for vocational rehabilitation (VR) is a list of essential categories on functioning based on the World Health Organization (WHO) International Classification of Functioning, Disability and Health (ICF), which describes a standard for interdisciplinary assessment, documentation, and communication in VR. The aim of this study was to examine the content validity of the Comprehensive ICF Core Set for VR from the perspective of physical therapists. A 3-round email survey was performed using the Delphi method. A convenience sample of international physical therapists working in VR with work experience of ≥2 years were asked to identify aspects they consider as relevant when evaluating or treating clients in VR. Responses were linked to the ICF categories and compared with the Comprehensive ICF Core Set for VR. Sixty-two physical therapists from all 6 WHO world regions responded with 3,917 statements that were subsequently linked to 338 ICF categories. Fifteen (17%) of the 90 categories in the Comprehensive ICF Core Set for VR were confirmed by the physical therapists in the sample. Twenty-two additional ICF categories were identified that were not included in the Comprehensive ICF Core Set for VR. Vocational rehabilitation in physical therapy is not well defined in every country and might have resulted in the small sample size. Therefore, the results cannot be generalized to all physical therapists practicing in VR. The content validity of the ICF Core Set for VR is insufficient from solely a physical therapist perspective. The results of this study could be used to define a physical therapy-specific set of ICF categories to develop and guide physical therapist clinical practice in VR. © 2016 American Physical Therapy Association.

  10. Improvement of the Cubic Spline Function Sets for a Synthesis of the Axial Power Distribution of a Core Protection System

    Energy Technology Data Exchange (ETDEWEB)

    Koo, Bon-Seung; Lee, Chung-Chan; Zee, Sung-Quun [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    2006-07-01

    Online digital core protection system(SCOPS) for a system-integrated modular reactor is being developed as a part of a plant protection system at KAERI. SCOPS calculates the minimum CHFR and maximum LPD based on several online measured system parameters including 3-level ex-core detector signals. In conventional ABB-CE digital power plants, cubic spline synthesis technique has been used in online calculations of the core axial power distributions using ex-core detector signals once every 1 second in CPC. In CPC, pre-determined cubic spline function sets are used depending on the characteristics of the ex-core detector responses. But this method shows an unnegligible power distribution error for the extremely skewed axial shapes by using restrictive function sets. Therefore, this paper describes the cubic spline method for the synthesis of an axial power distribution and it generates several new cubic spline function sets for the application of the core protection system, especially for the severely distorted power shapes needed reactor type.

  11. Protocol for the development of a core domain set for hidradenitis suppurativa trial outcomes

    Science.gov (United States)

    Thorlacius, Linnea; Garg, Amit; Villumsen, Bente; Esmann, Solveig; Kirby, Joslyn S; Gottlieb, Alice B; Merola, Joseph F; Dellavalle, Robert; Jemec, Gregor B E

    2017-01-01

    Introduction Randomised controlled trials (RCTs) should have well-defined primary and secondary outcomes to answer questions generated by the main hypotheses. However, for the chronic, inflammatory skin disease hidradenitis suppurativa (HS), the reported outcome measures are numerous and diverse. A recent systematic review found a total of 30 outcome measure instruments in 12 RCTs. This use of a broad range of outcome measures can increase difficulties in interpretation and comparison of results and may potentially obstruct appropriate evidence synthesis by causing reporting bias. One strategy for dealing with these problems is to develop a core outcome set (COS). A COS is a list of outcomes that are meant as mandatory and should be measured and reported in all clinical trials. The aim of this study is to develop a COS for the management of HS. Method and analysis An international steering group of researchers, clinicians and a patient research partner will guide the COS development. 6 stakeholder groups are involved: patients, dermatologists, surgeons, nurses, industry representatives and drug regulatory authorities. A 1:1 ratio of patients:healthcare professionals is aimed for. The initial list of candidate items will be obtained by combining three data sets: (1) a systematic review of the literature, (2) US and Danish qualitative interview studies involving patients with HS and (3) an online healthcare professional (HCP) item generation survey. To reach consensus on the COS, 4 anonymous online Delphi rounds are then planned together with 2 face-to-face consensus meetings (1 in Europe and 1 in the USA) to ensure global representation. Ethics and dissemination The study will be performed according to the Helsinki declaration. All results from the study, including inconclusive or negative results, will be published in peer-reviewed indexed journals. The study will involve different stakeholder groups to ensure that the developed COS will be suitable and well

  12. THE EFFECT OF SELF-SET GRADE GOALS AND CORE SELF-EVALUATIONS ON ACADEMIC PERFORMANCE: A DIARY STUDY.

    Science.gov (United States)

    Bipp, Tanja; Kleingeld, Ad; Van Den Tooren, Marieke; Schinkel, Sonja

    2015-12-01

    The aim of this diary study was to examine the effect of self-set grade goals and core self-evaluations on academic performance. Data were collected among 59 university students (M age = 18.4 yr., SD = 0.8) in a 2-wk. exam period on up to five exam days. Multilevel analyses revealed that the individual grade goals students set for their exams were positively related to the grades they obtained for these exams. However, the goal-performance relationship only applied to students scoring high on core self-evaluations. The results of this study contribute to the understanding of the effect of self-set grade goals and core self-evaluations on academic performance and imply important practical applications to enhance academic performance.

  13. Preliminary stratigraphic and petrologic characterization of core samples from USW-G1, Yucca Mountain, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Waters, A.C.; Carroll, P.R. (eds.)

    1981-11-01

    Tuffs of the Nevada Test Site are currently under investigation to determine their potential for long-term storage of radioactive waste. As part of this program, hole USW-G1 was drilled to a depth of 6000 ft below the surface, in the central part of the Yucca Mountain area, Nevada Test Site, Nevada. Petrographic study of the USW-G1 core is presented in this report and shows the tuffs (which generally were variably welded ash flows) are partly recrystallized to a variety of secondary minerals. The important alteration products are zeolites (heulandite, clinoptilolite, mordenite and analcime), smectite clays with minor interstratified illite, albite, micas, potassium feldspar, and various forms of silica. Iijima`s zeolite zones I through IV of burial metamorphism can be recognized in the core. Zeolites are first observed at about the 1300-ft depth, and the high-temperature boundary of zeolite stability in this core occurs at about 4350 ft. Analcime persists, either metastably or as a retrograde mineral, deeper in the core. The oxidation state of Fe-Ti oxide minerals, through most of the core, increases as the degree of welding decreases, but towards the bottom of the hole, reducing conditions generally prevail. Four stratigraphic units transected by the core may be potentially favorable sites for a waste repository. These four units, in order of increasing depth in the core, are (1) the lower cooling unit of the Topopah Spring Member, (2) cooling unit II of the Bullfrog Member, (3) the upper part of the Tram tuff, and (4) the Lithic-rich tuff.

  14. Citation analysis did not provide a reliable assessment of core outcome set uptake.

    Science.gov (United States)

    Barnes, Karen L; Kirkham, Jamie J; Clarke, Mike; Williamson, Paula R

    2017-06-01

    The aim of the study was to evaluate citation analysis as an approach to measuring core outcome set (COS) uptake, by assessing whether the number of citations for a COS report could be used as a surrogate measure of uptake of the COS by clinical trialists. Citation data were obtained for COS reports published before 2010 in five disease areas (systemic sclerosis, rheumatoid arthritis, eczema, sepsis and critical care, and female sexual dysfunction). Those publications identified as a report of a clinical trial were examined to identify whether or not all outcomes in the COS were measured in the trial. Clinical trials measuring the relevant COS made up a small proportion of the total number of citations for COS reports. Not all trials citing a COS report measured all the recommended outcomes. Some trials cited the COS reports for other reasons, including the definition of a condition or other trial design issues addressed by the COS report. Although citation data can be readily accessed, it should not be assumed that the citing of a COS report indicates that a trial has measured the recommended COS. Alternative methods for assessing COS uptake are needed. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  15. Improving core outcome set development: qualitative interviews with developers provided pointers to inform guidance.

    Science.gov (United States)

    Gargon, Elizabeth; Williamson, Paula R; Young, Bridget

    2017-06-01

    The objective of the study was to explore core outcome set (COS) developers' experiences of their work to inform methodological guidance on COS development and identify areas for future methodological research. Semistructured, audio-recorded interviews with a purposive sample of 32 COS developers. Analysis of transcribed interviews was informed by the constant comparative method and framework analysis. Developers found COS development to be challenging, particularly in relation to patient participation and accessing funding. Their accounts raised fundamental questions about the status of COS development and whether it is consultation or research. Developers emphasized how the absence of guidance had affected their work and identified areas where guidance or evidence about COS development would be useful including, patient participation, ethics, international development, and implementation. They particularly wanted guidance on systematic reviews, Delphi, and consensus meetings. The findings raise important questions about the funding, status, and process of COS development and indicate ways that it could be strengthened. Guidance could help developers to strengthen their work, but over specification could threaten quality in COS development. Guidance should therefore highlight common issues to consider and encourage tailoring of COS development to the context and circumstances of particular COS. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  16. Development of a core outcome set for clinical trials in facial aging: study protocol for a systematic review of the literature and identification of a core outcome set using a Delphi survey.

    Science.gov (United States)

    Schlessinger, Daniel I; Iyengar, Sanjana; Yanes, Arianna F; Henley, Jill K; Ashchyan, Hovik J; Kurta, Anastasia O; Patel, Payal M; Sheikh, Umar A; Franklin, Matthew J; Hanna, Courtney C; Chen, Brian R; Chiren, Sarah G; Schmitt, Jochen; Deckert, Stefanie; Furlan, Karina C; Poon, Emily; Maher, Ian A; Cartee, Todd V; Sobanko, Joseph F; Alam, Murad

    2017-08-01

    Facial aging is a concern for many patients. Wrinkles, loss of volume, and discoloration are common physical manifestations of aging skin. Genetic heritage, prior ultraviolet light exposure, and Fitzpatrick skin type may be associated with the rate and type of facial aging. Although many clinical trials assess the correlates of skin aging, there is heterogeneity in the outcomes assessed, which limits the quality of evaluation and comparison of treatment modalities. To address the inconsistency in outcomes, in this project we will develop a core set of outcomes that are to be evaluated in all clinical trials relevant to facial aging. A long list of measureable outcomes will be created from four sources: (1) systematic medical literature review, (2) patient interviews, (3) other published sources, and (4) stakeholder involvement. Two rounds of Delphi processes with homogeneous groups of physicians and patients will be performed to prioritize and condense the list. At a consensus meeting attended by physicians, patients, and stakeholders, outcomes will be further condensed on the basis of participant scores. By the end of the meeting, members will vote and decide on a final recommended set of core outcomes. Subsequent to this, specific measures will be selected or created to assess these outcomes. The aim of this study is to develop a core outcome set and relevant measures for clinical trials relevant to facial aging. We hope to improve the reliability and consistency of outcome reporting of skin aging, thereby enabling improved evaluation of treatment efficacy and patient satisfaction. Core Outcome Measures in Effectiveness Trials (COMET) Initiative, accessible at http://www.comet-initiative.org/studies/details/737 . Core Outcomes Set Initiative, (CSG-COUSIN) accessible at https://www.uniklinikum-dresden.de/de/das-klinikum/universitaetscentren/zegv/cousin/meet-the-teams/project-groups/core-outcome-set-for-the-appearance-of-facial-aging . Protocol version date is 28

  17. HSDP II Drill Core: Preliminary Rock Strength Results and Implications to Flank Stability, Mauna Kea Volcano

    Science.gov (United States)

    Thompson, N.; Watters, R. J.; Schiffman, P.

    2004-12-01

    Selected portions of the 3-km HSDP II core were tested to provide unconfined rock strength data from hyaloclastite alteration zones and pillow lavas. Though the drilling project was not originally intended for strength purpose, it is believed the core can provide unique rock strength insights into the flank stability of the Hawaiian Islands. The testing showed that very weak rock exists in the hyaloclastite abundant zones in the lower 2-km of the core with strength dependent on the degree of consolidation and type of alteration. Walton and Schiffman identified three zones of alteration, an upper incipient alteration zone (1080-1335m), a smectitic zone (1405-1573m) and a lower palagonitic zone from about 1573 m to the base of the core. These three zones were sampled and tested together with pillow lava horizons for comparison. Traditional cylindrical core was not available as a consequence of the entire core having been split lengthwise for archival purposes. Hence, point load strength testing was utilized which provides the unconfined compressive strength on irregular shaped samples. The lowest unconfined strengths were recorded from incipient alteration zones with a mean value of 9.5 MPa. Smectitic alteration zones yielded mean values of 16.4 MPa, with the highest measured alteration strengths from the palagonite zones with a mean value of 32.1 MPa. As anticipated, the highest strengths were from essentially unaltered lavas with a mean value of 173 MPa. Strength variations of between one to two orders of magnitude were identified in comparing the submarine hyaloclastite with the intercalated submarine lavas. The weakest zones within the hyaloclastites may provide horizons for assisting flank collapse by serving as potential thrust zones and landslide surfaces.

  18. CORE

    DEFF Research Database (Denmark)

    Krigslund, Jeppe; Hansen, Jonas; Hundebøll, Martin

    2013-01-01

    different flows. Instead of maintaining these approaches separate, we propose a protocol (CORE) that brings together these coding mechanisms. Our protocol uses random linear network coding (RLNC) for intra- session coding but allows nodes in the network to setup inter- session coding regions where flows...... intersect. Routes for unicast sessions are agnostic to other sessions and setup beforehand, CORE will then discover and exploit intersecting routes. Our approach allows the inter-session regions to leverage RLNC to compensate for losses or failures in the overhearing or transmitting process. Thus, we...... increase the benefits of XORing by exploiting the underlying RLNC structure of individual flows. This goes beyond providing additional reliability to each individual session and beyond exploiting coding opportunistically. Our numerical results show that CORE outperforms both forwarding and COPE...

  19. CORE

    DEFF Research Database (Denmark)

    Krigslund, Jeppe; Hansen, Jonas; Hundebøll, Martin

    2013-01-01

    different flows. Instead of maintaining these approaches separate, we propose a protocol (CORE) that brings together these coding mechanisms. Our protocol uses random linear network coding (RLNC) for intra- session coding but allows nodes in the network to setup inter- session coding regions where flows...... intersect. Routes for unicast sessions are agnostic to other sessions and setup beforehand, CORE will then discover and exploit intersecting routes. Our approach allows the inter-session regions to leverage RLNC to compensate for losses or failures in the overhearing or transmitting process. Thus, we...... increase the benefits of XORing by exploiting the underlying RLNC structure of individual flows. This goes beyond providing additional reliability to each individual session and beyond exploiting coding opportunistically. Our numerical results show that CORE outperforms both forwarding and COPE...

  20. Preliminary design report for SCDAP/RELAP5 lower core plate model

    Energy Technology Data Exchange (ETDEWEB)

    Coryell, E.W. [Lockheed Martin Idaho Technologies Co., Idaho Falls, ID (United States). Idaho National Engineering and Environmental Lab.; Griffin, F.P. [Oak Ridge National Lab., TN (United States)

    1998-07-01

    The SCDAP/RELAP5 computer code is a best-estimate analysis tool for performing nuclear reactor severe accident simulations. Under primary sponsorship of the US Nuclear Regulatory Commission (NRC), Idaho National Engineering and Environmental Laboratory (INEEL) is responsible for overall maintenance of this code and for improvements for pressurized water reactor (PWR) applications. Since 1991, Oak Ridge National Laboratory (ORNL) has been improving SCDAP/RELAP5 for boiling water reactor (BWR) applications. The RELAP5 portion of the code performs the thermal-hydraulic calculations for both normal and severe accident conditions. The structures within the reactor vessel and coolant system can be represented with either RELAP5 heat structures or SCDAP/RELAP5 severe accident structures. The RELAP5 heat structures are limited to normal operating conditions (i.e., no structural oxidation, melting, or relocation), while the SCDAP portion of the code is capable of representing structural degradation and core damage progression that can occur under severe accident conditions. DCDAP/RELAP5 currently assumes that molten material which leaves the core region falls into the lower vessel head without interaction with structural materials. The objective of this design report is to describe the modifications required for SCDAP/RELAP5 to treat the thermal response of the structures in the core plate region as molten material relocates downward from the core, through the core plate region, and into the lower plenum. This has been a joint task between INEEL and ORNL, with INEEL focusing on PWR-specific design, and ORNL focusing upon the BWR-specific aspects. Chapter 2 describes the structures in the core plate region that must be represented by the proposed model. Chapter 3 presents the available information about the damage progression that is anticipated to occur in the core plate region during a severe accident, including typical SCDAP/RELAP5 simulation results. Chapter 4 provides a

  1. Preliminary Physical Stratigraphy and Geophysical Data From the USGS Dixon Core, Onslow County, North Carolina

    Science.gov (United States)

    Seefelt, Ellen L.; Gonzalez, Wilma Aleman B.; Self-Trail, Jean M.; Weems, Robert E.; Edwards, Lucy E.; Pierce, Herbert A.; Durand, Colleen T.

    2009-01-01

    In October through November 2006, scientists from the U. S. Geological Survey (USGS) Eastern Region Earth Surface Processes Team (EESPT) and the Raleigh (N.C.) Water Science Center (WSC), in cooperation with the North Carolina Geological Survey (NCGS) and the Onslow County Water and Sewer Authority (ONWASA), drilled a stratigraphic test hole and well in Onslow County, N.C. The Dixon corehole was cored on ONWASA water utility property north of the town of Dixon, N.C., in the Sneads Ferry 7.5-minute quadrangle at latitude 34deg33'35' N, longitude 77deg26'54' W (decimal degrees 34.559722 and -77.448333). The site elevation is 66.0 feet (ft) above mean sea level as determined using a Paulin precision altimeter. The corehole attained a total depth of 1,010 ft and was continuously cored by the USGS EESPT drilling crew. A groundwater monitoring well was installed in the screened interval between 234 and 254 ft below land surface. The section cored at this site includes Upper Cretaceous, Paleogene, and Neogene sediments. The Dixon core is stored at the NCGS Coastal Plain core storage facility in Raleigh. The Dixon corehole is the fourth and last in a series of planned North Carolina benchmark coreholes drilled by the USGS Coastal Carolina Project. These coreholes explore the physical stratigraphy, facies, and thickness of Cretaceous, Paleogene, and Neogene Coastal Plain sediments in North Carolina. Correlations of lithologies, facies, and sequence stratigraphy can be made with the Hope Plantation corehole, N.C., near Windsor in Bertie County (Weems and others, 2007); the Elizabethtown corehole, near Elizabethtown, N.C., in Bladen County (Self-Trail and others, 2004b); the Smith Elementary School corehole, near Cove City, N.C., in Craven County (Harris and Self-Trail, 2006; Crocetti, 2007); the Kure Beach corehole, near Wilmington, N.C., in New Hanover County (Self-Trail and others, 2004a); the Esso#1, Esso #2, Mobil #1, and Mobil #2 cores in Albermarle and Pamlico Sounds

  2. Protein folding: Defining a standard set of experimental conditions and a preliminary kinetic data set of two-state proteins

    DEFF Research Database (Denmark)

    Maxwell, Karen L.; Wildes, D.; Zarrine-Afsar, A.;

    2005-01-01

    constructs. The lack of a single approach to data analysis and error estimation, or even of a common set of units and reporting standards, further hinders comparative studies of folding. In an effort to overcome these problems, we define here a consensus set of experimental conditions (25°C at pH 7.0, 50 m...... rates, thermodynamics, and structure across diverse sets of proteins. These difficulties include the wide, potentially confounding range of experimental conditions and methods employed to date and the difficulty of obtaining correct and complete sequence and structural details for the characterized......M buffer), data analysis methods, and data reporting standards that we hope will provide a benchmark for experimental studies. We take the first step in this initiative by describing the folding kinetics of 30 apparently two-state proteins or protein domains under the consensus conditions. The goal of our...

  3. The use of qualitative methods to inform Delphi surveys in core outcome set development.

    Science.gov (United States)

    Keeley, T; Williamson, P; Callery, P; Jones, L L; Mathers, J; Jones, J; Young, B; Calvert, M

    2016-05-04

    Core outcome sets (COS) help to minimise bias in trials and facilitate evidence synthesis. Delphi surveys are increasingly being used as part of a wider process to reach consensus about what outcomes should be included in a COS. Qualitative research can be used to inform the development of Delphi surveys. This is an advance in the field of COS development and one which is potentially valuable; however, little guidance exists for COS developers on how best to use qualitative methods and what the challenges are. This paper aims to provide early guidance on the potential role and contribution of qualitative research in this area. We hope the ideas we present will be challenged, critiqued and built upon by others exploring the role of qualitative research in COS development. This paper draws upon the experiences of using qualitative methods in the pre-Delphi stage of the development of three different COS. Using these studies as examples, we identify some of the ways that qualitative research might contribute to COS development, the challenges in using such methods and areas where future research is required. Qualitative research can help to identify what outcomes are important to stakeholders; facilitate understanding of why some outcomes may be more important than others, determine the scope of outcomes; identify appropriate language for use in the Delphi survey and inform comparisons between stakeholder data and other sources, such as systematic reviews. Developers need to consider a number of methodological points when using qualitative research: specifically, which stakeholders to involve, how to sample participants, which data collection methods are most appropriate, how to consider outcomes with stakeholders and how to analyse these data. A number of areas for future research are identified. Qualitative research has the potential to increase the research community's confidence in COS, although this will be dependent upon using rigorous and appropriate

  4. Development of a core outcome set for medication review in older patients with multimorbidity and polypharmacy: a study protocol.

    Science.gov (United States)

    Beuscart, Jean-Baptiste; Dalleur, Olivia; Boland, Benoit; Thevelin, Stefanie; Knol, Wilma; Cullinan, Shane; Schneider, Claudio; O'Mahony, Denis; Rodondi, Nicolas; Spinewine, Anne

    2017-01-01

    Medication review has been advocated to address the challenge of polypharmacy in older patients, yet there is no consensus on how best to evaluate its efficacy. Heterogeneity of outcomes reported in clinical trials can hinder the comparison of clinical trial findings in systematic reviews. Moreover, the outcomes that matter most to older patients might be under-reported or disregarded altogether. A core outcome set can address this issue as it defines a minimum set of outcomes that should be reported in all clinical trials in any particular field of research. As part of the European Commission-funded project, called OPtimising thERapy to prevent Avoidable hospital admissions in the Multimorbid elderly, this paper describes the methods used to develop a core outcome set for clinical trials of medication review in older patients with multimorbidity. The study was designed in several steps. First, a systematic review established which outcomes were measured in published and ongoing clinical trials of medication review in older patients. Second, we undertook semistructured interviews with older patients and carers aimed at identifying additional relevant outcomes. Then, a multilanguage European Delphi survey adapted to older patients was designed. The international Delphi survey was conducted with older patients, health care professionals, researchers, and clinical experts in geriatric pharmacotherapy to validate outcomes to be included in the core outcome set. Consensus meetings were conducted to validate the results. We present the method for developing a core outcome set for medication review in older patients with multimorbidity. This study protocol could be used as a basis to develop core outcome sets in other fields of geriatric research.

  5. Development and testing of a compact basis set for use in effective core potential calculations on rhodium complexes.

    Science.gov (United States)

    Roscioni, Otello M; Lee, Edmond P F; Dyke, John M

    2012-10-05

    We present a set of effective core potential (ECP) basis sets for rhodium atoms which are of reasonable size for use in electronic structure calculations. In these ECP basis sets, the Los Alamos ECP is used to simulate the effect of the core electrons while an optimized set of Gaussian functions, which includes polarization and diffuse functions, is used to describe the valence electrons. These basis sets were optimized to reproduce the ionization energy and electron affinity of atomic rhodium. They were also tested by computing the electronic ground state geometry and harmonic frequencies of [Rh(CO)(2) μ-Cl](2) , Rh(CO)(2) ClPy, and RhCO (neutral and its positive, and negative ions) as well as the enthalpy of the reaction of [Rh(CO)(2) μ-Cl](2) with pyridine (Py) to give Rh(CO)(2) ClPy, at different levels of theory. Good agreement with experimental values was obtained. Although the number of basis functions used in our ECP basis sets is smaller than those of other ECP basis sets of comparable quality, we show that the newly developed ECP basis sets provide the flexibility and precision required to reproduce a wide range of chemical and physical properties of rhodium compounds. Therefore, we recommend the use of these compact yet accurate ECP basis sets for electronic structure calculations on molecules involving rhodium atoms. Copyright © 2012 Wiley Periodicals, Inc.

  6. Content Validity of the Comprehensive ICF Core Set for Chronic Obstructive Pulmonary Diseases: An International Delphi Survey.

    Science.gov (United States)

    Jobst, Andrea; Kirchberger, Inge; Cieza, Alarcos; Stucki, Gerold; Stucki, Armin

    2013-01-01

    The "Comprehensive ICF Core Set for Chronic Obstructive Pulmonary Diseases (COPD)" is an application of the International Classification of Functioning, Disability and Health (ICF) and represents the typical spectrum of problems in functioning of patients with COPD. The objective of this study was to validate this ICF Core Set from the perspective of physicians. Physicians experienced in COPD treatment were asked about the patients' problems treated by physicians in patients with COPD in a three-round electronic mail survey using the Delphi technique. Responses were linked to the ICF. Seventy-six physicians in 44 countries gave a total of 1330 responses that were linked to 148 different ICF categories. Nine ICF categories were not represented in the Comprehensive ICF Core Set for COPD although at least 75% of the participants have rated them as important. Nineteen concepts were linked to the not yet developed ICF component personal factors and seventeen concepts were not covered by the ICF. The high percentage of ICF categories represented in the ICF Core Set for COPD indicates satisfactory content validity from the perspective of the physicians. However, some issues were raised that were not covered and need to be investigated further.

  7. ICF Core Set for Head and Neck Cancer: Do the Categories Discriminate Among Clinically Relevant Subgroups of Patients?

    Science.gov (United States)

    Tschiesner, Uta; Oberhauser, Cornelia; Cieza, Alarcos

    2011-01-01

    The multidisciplinary assessment of functioning in patients with head and neck cancer (HNC) according to the "ICF Core Set for Head and Neck Cancer" (ICF-HNC) was developed in an international and multi-disciplinary approach. The ICF-HNC is an application of the ICF that was adopted by the World Health Organization. The objective of this study was…

  8. Low Back Pain in 17 Countries, a Rasch Analysis of the ICF Core Set for Low Back Pain

    Science.gov (United States)

    Roe, Cecilie; Bautz-Holter, Erik; Cieza, Alarcos

    2013-01-01

    Previous studies indicate that a worldwide measurement tool may be developed based on the International Classification of Functioning Disability and Health (ICF) Core Sets for chronic conditions. The aim of the present study was to explore the possibility of constructing a cross-cultural measurement of functioning for patients with low back pain…

  9. Low Back Pain in 17 Countries, a Rasch Analysis of the ICF Core Set for Low Back Pain

    Science.gov (United States)

    Roe, Cecilie; Bautz-Holter, Erik; Cieza, Alarcos

    2013-01-01

    Previous studies indicate that a worldwide measurement tool may be developed based on the International Classification of Functioning Disability and Health (ICF) Core Sets for chronic conditions. The aim of the present study was to explore the possibility of constructing a cross-cultural measurement of functioning for patients with low back pain…

  10. Preliminary petrographic and geophysical interpretations of the exploratory geothermal drill hole and core, Redstone, New Hampshire

    Energy Technology Data Exchange (ETDEWEB)

    Hoag, R.B. Jr.; Stewart, G.W.

    1977-06-30

    A 3000 foot diamond drill hole was drilled in the Conway Granite in Redstone, New Hampshire. A comprehensive detailed petrographic and physical study of this core was made. The purpose of this study is to supply a sound data base for future geothermal and uranium-thorium studies of the drill core. An estimate of the heat flow potential of the Redstone drill hole gives a heat flow of 1.9 HFU. If only the red phase of the Conway Granite had been intersected the heat flow may have been as much as 2.7 HFU, reaching a temperature of 260/sup 0/C at 6 km. The drill hole intersected four lithologies; the green and red phase of the Conway Granite, the Albany quartz syenite and a medium-grained, hastingsite-biotite granite. The red phase has the highest and most irregular radioactivity. The irregularity is mainly due to minor variations in lithology. The drill core intersected several alteration zones up to a thickness of 150 feet. These alteration zones represent passage of low to medium temperature fluids which might have been mineralized. The Conway Granite has the physical and chemical characteristics necessary for the formation of vein type uranium deposits. The presence of unexplained radiometric anomalies lends support to the existence of such deposits.

  11. Development of a core outcome set for clinical trials in squamous cell carcinoma: study protocol for a systematic review of the literature and identification of a core outcome set using a Delphi survey.

    Science.gov (United States)

    Schlessinger, Daniel I; Iyengar, Sanjana; Yanes, Arianna F; Chiren, Sarah G; Godinez-Puig, Victoria; Chen, Brian R; Kurta, Anastasia O; Schmitt, Jochen; Deckert, Stefanie; Furlan, Karina C; Poon, Emily; Cartee, Todd V; Maher, Ian A; Alam, Murad; Sobanko, Joseph F

    2017-07-12

    Squamous cell carcinoma (SCC) is a common skin cancer that poses a risk of metastasis. Clinical investigations into SCC treatment are common, but the outcomes reported are highly variable, omitted, or clinically irrelevant. The outcome heterogeneity and reporting bias of these studies leave clinicians unable to accurately compare studies. Core outcome sets (COSs) are an agreed minimum set of outcomes recommended to be measured and reported in all clinical trials of a given condition or disease. Although COSs are under development for several dermatologic conditions, work has yet to be done to identify core outcomes specific for SCC. Outcome extraction for COS generation will occur via four methods: (1) systematic literature review; (2) patient interviews; (3) other published sources; and (4) input from stakeholders in medicine, pharmacy, and other relevant industries. The list of outcomes will be revaluated by the Measuring PRiority Outcome Variables via Excellence in Dermatologic surgery (IMPROVED) Steering Committee. Delphi processes will be performed separately by expert clinicians and patients to condense the list of outcomes generated. A consensus meeting with relevant stakeholders will be conducted after the Delphi exercise to further select outcomes, taking into account participant scores. At the end of the meeting, members will vote and decide on a final recommended set of core outcomes. The Core Outcome Measures in Effectiveness Trials (COMET) organization and the Cochrane Skin Group - Core Outcome Set Initiative (CSG-COUSIN) will serve as advisers throughout the COS generation process. Comparison of clinical trials via systematic reviews and meta-analyses is facilitated when investigators study outcomes that are relevant and similar. The aim of this project is to develop a COS to guide use for future clinical trials.

  12. Responsiveness of the functioning and disability parts of the International Classification of Functioning, Disability, and Health core sets in postacute stroke patients.

    Science.gov (United States)

    Kinoshita, Shoji; Abo, Masahiro; Okamoto, Takatsugu; Kakuda, Wataru; Miyamura, Kohei; Kimura, Ikuo

    2017-09-01

    To study the responsiveness of the International Classification of Functioning, Disability, and Health (ICF) core set with respect to human functioning and disability in stroke patients. Postacute stroke patients who were admitted to the convalescent rehabilitation wards were included in this observational cohort study. The comprehensive ICF core set for neurological conditions for postacute care and the ICF rehabilitation set were evaluated at admission and discharge using five-grade qualifiers. Extension indexes were calculated for entire two ICF core sets. Responsiveness was measured as change in the extension indexes in the ICF core sets. The correlation between changes in ICF core sets and improvement in the Functional Independence Measure (FIM) was analyzed using Spearman's correlation coefficient. The study included 108 poststroke patients (49 women, mean age 70.8 years, mean FIM score improvement: 23.0). The mean percentage of categories that showed changes with at least one qualifier level was 19.5% in the comprehensive ICF core set for neurological conditions for postacute care and 35.9% in the ICF rehabilitation set. Effect sizes in each ICF core set were moderate to large (0.79-0.80). Improvement in the two ICF core sets correlated significantly with changes in the FIM score. Our results indicate that functioning and disability parts of these two ICF core sets can detect changes in functioning and disability in patients who receive an inpatient rehabilitation program for postacute stroke.

  13. Preliminary analysis of grain-size populations with environmentally sensitive terrigenous components in marginal sea setting

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Terrigenous components were separated from the bulk sediment of Core A7 from the Okinawa Trough and Core A37 from the Ryukru Trench and grain-size distributions of these sub-samples were analyzed. Based upon an analysis of the grain-size data of the two sedimentary sequences, grain-size populations are identified to be sensitive to sedimentary environmental changes. The modal values and size ranges of the two main grain-size populations in Core A7 are evidently different from those of Core A37, indicating the spatial variability of sediment sources and transport processes between the two places. The downcore variations in the content of the environmentally sensitive grain-size populations reveal that during the accumulation of sedimentary material the environment remained relatively stable at the site where Core A7 was collected, except for the apparent events for the formation of two turbidite layers and a volcanic ash layer. However, the sedimentary sequence of Core A37 shows six sedimentary cycles, indicating a highly variable sedimentary environment at this location.

  14. YOUNG STARLESS CORES EMBEDDED IN THE MAGNETICALLY DOMINATED PIPE NEBULA. II. EXTENDED DATA SET

    Energy Technology Data Exchange (ETDEWEB)

    Frau, P.; Girart, J. M.; Padovani, M. [Institut de Ciencies de l' Espai (CSIC-IEEC), Campus UAB, Facultat de Ciencies, Torre C-5p, E-08193 Bellaterra, Catalunya (Spain); Beltran, M. T.; Sanchez-Monge, A. [INAF-Osservatorio Astrofisico di Arcetri, Largo Enrico Fermi 5, I-50125 Firenze (Italy); Busquet, G. [INAF-Istituto di Astrofisica e Planetologia Spaziali, via Fosso del Cavaliere 100, I-00133 Roma (Italy); Morata, O. [Institute of Astronomy and Astrophysics, Academia Sinica, P.O. Box 23-141, Taipei 10617, Taiwan (China); Masque, J. M.; Estalella, R. [Departament d' Astronomia i Meteorologia and Institut de Ciencies del Cosmos (IEEC-UB), Universitat de Barcelona, Marti i Franques 1, E-08028 Barcelona, Catalunya (Spain); Alves, F. O. [Argelander-Institut fuer Astronomie der Universitaet Bonn, Auf dem Huegel 71, D-53121 Bonn (Germany); Franco, G. A. P. [Departamento de Fisica-ICEx-UFMG, Caixa Postal 702, 30.123-970, Belo Horizonte (Brazil)

    2012-11-01

    The Pipe nebula is a massive, nearby, filamentary dark molecular cloud with a low star formation efficiency threaded by a uniform magnetic field perpendicular to its main axis. It harbors more than a hundred, mostly quiescent, very chemically young starless cores. The cloud is therefore a good laboratory to study the earliest stages of the star formation process. We aim to investigate the primordial conditions and the relation among physical, chemical, and magnetic properties in the evolution of low-mass starless cores. We used the IRAM 30 m telescope to map the 1.2 mm dust continuum emission of five new starless cores, which are in good agreement with previous visual extinction maps. For the sample of nine cores, which includes the four cores studied in a previous work, we derived an A {sub V} to N{sub H{sub 2}} factor of (1.27 {+-} 0.12) Multiplication-Sign 10{sup -21} mag cm{sup 2} and a background visual extinction of {approx}6.7 mag possibly arising from the cloud material. We derived an average core diameter of {approx}0.08 pc, density of {approx}10{sup 5} cm{sup -3}, and mass of {approx}1.7 M {sub Sun }. Several trends seem to exist related to increasing core density: (1) the diameter seems to shrink, (2) the mass seems to increase, and (3) the chemistry tends to be richer. No correlation is found between the direction of the surrounding diffuse medium magnetic field and the projected orientation of the cores, suggesting that large-scale magnetic fields seem to play a secondary role in shaping the cores. We also used the IRAM 30 m telescope to extend the previous molecular survey at 1 and 3 mm of early- and late-time molecules toward the same five new Pipe nebula starless cores, and analyzed the normalized intensities of the detected molecular transitions. We confirmed the chemical differentiation toward the sample and increased the number of molecular transitions of the 'diffuse' (e.g., the 'ubiquitous' CO, C{sub 2}H, and CS), &apos

  15. Genetic characterization of a core set of a tropical maize race Tuxpeno for further use in maize improvement.

    Directory of Open Access Journals (Sweden)

    Weiwei Wen

    Full Text Available The tropical maize race Tuxpeño is a well-known race of Mexican dent germplasm which has greatly contributed to the development of tropical and subtropical maize gene pools. In order to investigate how it could be exploited in future maize improvement, a panel of maize germplasm accessions was assembled and characterized using genome-wide Single Nucleotide Polymorphism (SNP markers. This panel included 321 core accessions of Tuxpeño race from the International Maize and Wheat Improvement Center (CIMMYT germplasm bank collection, 94 CIMMYT maize lines (CMLs and 54 U.S. Germplasm Enhancement of Maize (GEM lines. The panel also included other diverse sources of reference germplasm: 14 U.S. maize landrace accessions, 4 temperate inbred lines from the U.S. and China, and 11 CIMMYT populations (a total of 498 entries with 795 plants. Clustering analyses (CA based on Modified Rogers Distance (MRD clearly partitioned all 498 entries into their corresponding groups. No sub clusters were observed within the Tuxpeño core set. Various breeding strategies for using the Tuxpeño core set, based on grouping of the studied germplasm and genetic distance among them, were discussed. In order to facilitate sampling diversity within the Tuxpeño core, a minicore subset of 64 Tuxpeño accessions (20% of its usual size representing the diversity of the core set was developed, using an approach combining phenotypic and molecular data. Untapped diversity represents further use of the Tuxpeño landrace for maize improvement through the core and/or minicore subset available to the maize community.

  16. Development of a core outcome set for medication review in older patients with multimorbidity and polypharmacy: a study protocol

    Directory of Open Access Journals (Sweden)

    Beuscart JB

    2017-08-01

    Full Text Available Jean-Baptiste Beuscart,1 Olivia Dalleur,1 Benoit Boland,2 Stefanie Thevelin,1 Wilma Knol,3 Shane Cullinan,4 Claudio Schneider,5 Denis O’Mahony,6 Nicolas Rodondi,4,7 Anne Spinewine1,8 1Université catholique de Louvain, Louvain Drug Research Institute, Clinical Pharmacy Research Group, Brussels, Belgium; 2Geriatric Medicine, Cliniques universitaires Saint-Luc, Brussels, Université catholique de Louvain, Belgium; 3Department of Geriatric Medicine and Expertise Centre Pharmacotherapy in Old Persons (EPHOR, University Medical Centre Utrecht, Netherlands; 4School of Pharmacy, Royal College of Surgeons in Ireland, Dublin, Ireland; 5Department of General Internal Medicine, Bern University Hospital, Bern, Switzerland; 6Department of Medicine (Geriatrics, University College Cork, Cork, Ireland; 7Institute of Primary Health Care (BIHAM, University of Bern, Bern, Switzerland; 8Université catholique de Louvain, CHU UCL Namur, Pharmacy Department, Yvoir, Belgium Background: Medication review has been advocated to address the challenge of polypharmacy in older patients, yet there is no consensus on how best to evaluate its efficacy. Heterogeneity of outcomes reported in clinical trials can hinder the comparison of clinical trial findings in systematic reviews. Moreover, the outcomes that matter most to older patients might be under-reported or disregarded altogether. A core outcome set can address this issue as it defines a minimum set of outcomes that should be reported in all clinical trials in any particular field of research. As part of the European Commission-funded project, called OPtimising thERapy to prevent Avoidable hospital admissions in the Multimorbid elderly, this paper describes the methods used to develop a core outcome set for clinical trials of medication review in older patients with multimorbidity. Methods/design: The study was designed in several steps. First, a systematic review established which outcomes were measured in published

  17. Preliminary Results from a Late Pleistocene to Holocene Paleoclimate Study of the Lake Sediment Cores, Northern New Mexico

    Science.gov (United States)

    Cedillo, D. N.; Brister, A. R.; LoPresti, C. A.; Maldonado, M.; Pitrucha, R. M.; West, C.; Martinez, E.; Lineline, J.; Petronis, M. S.

    2011-12-01

    We present the preliminary results from an integrated, paleoclimatic study of sediment cores collected from the Las Vegas National Wildlife Refuge (LVNWR) and surrounding region that bear on the late Pleistocene to Holocene paleoclimatic variations in northeastern NM. We collected sedimentologic, midge fossil, and rock magnetic data from sediment cores to characterize the materials, identify stratigraphic changes, document shifting lake levels, assess temperature changes, and infer paleoclimate conditions. Data from McAllister and Wallace Lake are encouraging and reveal depth dependent changes in fossil assemblages, grain size, and rock magnetic properties that we interpret to reflect climatic driven variations impacting the depositional system. We recognize three different types of chironomid subfamilies (Chironomini, Tanypodinae, and Orthocladiinae). Based on the fossil results, the water has been warm in the most recent years. Grain size distribution from the lower to upper core levels reveal that the amount of fine sand-sized sediment (0.125 mm diameter) increases while the amount of medium (0.25) to coarse (0.50) sand-sized sediment decreases implying that there may have been a reduction in stream energy and hence precipitation over the time period represented by the core. Bulk low-field magnetic susceptibility decreases by an order of magnitude from the surface to the base of the measured core suggesting a change in detrital magnetic influx into the lacustrian system. Curie point estimates indicate that the dominant magnetic mineral in all samples is cubic, low-Ti titanomagnetite phase. We postulate that concurrent with alpine glacial activity during the Pleistocene, the LVNWR and the transitional Great Plains region to the northeast was an expansive single lake or interconnected lake system, analogous to the Pleistocene lakes of the Estancia Basin (Lake Estancia) and the Tularosa Basin (Lake Otero) of central and southern NM. Following the end of glacial

  18. Recommendations for a first Core Outcome Measurement set for complex regional PAin syndrome Clinical sTudies (COMPACT).

    Science.gov (United States)

    Grieve, Sharon; Perez, Roberto Sgm; Birklein, Frank; Brunner, Florian; Bruehl, Stephen; Harden, R Norman; Packham, Tara; Gobeil, Francois; Haigh, Richard; Holly, Janet; Terkelsen, Astrid; Davies, Lindsay; Lewis, Jennifer; Thomassen, Ilona; Connett, Robyn; Worth, Tina; Vatine, Jean-Jacques; McCabe, Candida S

    2017-02-04

    Complex Regional Pain Syndrome (CRPS) is a persistent pain condition that remains incompletely understood and challenging to treat. Historically, a wide range of different outcome measures have been used to capture the multidimensional nature of CRPS. This has been a significant limiting factor in the advancement of our understanding of the mechanisms and management of CRPS.In 2013, an international consortium of patients, clinicians, researchers and industry representatives was established, to develop and agree on a minimum core set of standardised outcome measures for use in future CRPS clinical research, including but not limited to clinical trials within adult populationsThe development of a core measurement set was informed through workshops and supplementary work, using an iterative consensus process. 'What is the clinical presentation and course of CRPS, and what factors influence it?' was agreed as the most pertinent research question that our standardised set of patient-reported outcome measures should be selected to answer. The domains encompassing the key concepts necessary to answer the research question were agreed as: pain, disease severity, participation and physical function, emotional and psychological function, self efficacy, catastrophizing and patient's global impression of change. The final core measurement set included the optimum generic or condition-specific patient-reported questionnaire outcome measures, which captured the essence of each domain, and one clinician reported outcome measure to capture the degree of severity of CRPS. The next step is to test the feasibility and acceptability of collecting outcome measure data using the core measurement set in the CRPS population internationally.

  19. Exploring core competencies for mental health and addictions work within a Family Health Team setting.

    Science.gov (United States)

    Rush, Brian; McPherson-Doe, Catherine; Behrooz, Reneé C; Cudmore, Alan

    2013-06-01

    Approximately 200 Family Health Teams (FHTs) have been implemented in Ontario to improve access to primary healthcare, including mental health and addiction. The objectives of this project were to examine, through a focus group and qualitative methodology with three FHTs, the profile of patients' mental health and addiction-related needs and to identify the implications for the development of core competencies in these innovative organisations. A spectrum of needs and service trajectories was identified, as well as the importance of a wide range of clinical skills and knowledge. The results indicate that 'core' competencies for mental health work in the context of an FHT go well beyond those required for an embedded mental health 'programme' or specialised mental health counsellors, but rather they relate to the core and discipline-specific competencies of members of the entire team. In addition to specific knowledge and skills, competencies include common attitudes and values relating to teamwork, good communication and collaboration. Challenges were noted with regard to working with some community service providers, especially addiction services. Implications for core competencies at the individual and organisational level were identified.

  20. A Common Set of Core Values - The Foundation for a More Effective Joint Force

    Science.gov (United States)

    2015-05-18

    Iraqi Freedom, Cobra II, they describe that despite the heralded jointness of the operations the Army and Marine Corps essentially fought service...changed without the resulting 10 Michael R. Gordon and General (Ret.) Bernard E. Trainor, Cobra II...cornerstone, the bedrock, and the heart of our character.”16 Core 12 National Defense University

  1. Connective tissue disease related interstitial lung diseases and idiopathic pulmonary fibrosis: provisional core sets of domains and instruments for use in clinical trials.

    Science.gov (United States)

    Saketkoo, Lesley Ann; Mittoo, Shikha; Huscher, Dörte; Khanna, Dinesh; Dellaripa, Paul F; Distler, Oliver; Flaherty, Kevin R; Frankel, Sid; Oddis, Chester V; Denton, Christopher P; Fischer, Aryeh; Kowal-Bielecka, Otylia M; LeSage, Daphne; Merkel, Peter A; Phillips, Kristine; Pittrow, David; Swigris, Jeffrey; Antoniou, Katerina; Baughman, Robert P; Castelino, Flavia V; Christmann, Romy B; Christopher-Stine, Lisa; Collard, Harold R; Cottin, Vincent; Danoff, Sonye; Highland, Kristin B; Hummers, Laura; Shah, Ami A; Kim, Dong Soon; Lynch, David A; Miller, Frederick W; Proudman, Susanna M; Richeldi, Luca; Ryu, Jay H; Sandorfi, Nora; Sarver, Catherine; Wells, Athol U; Strand, Vibeke; Matteson, Eric L; Brown, Kevin K; Seibold, James R

    2014-05-01

    Clinical trial design in interstitial lung diseases (ILDs) has been hampered by lack of consensus on appropriate outcome measures for reliably assessing treatment response. In the setting of connective tissue diseases (CTDs), some measures of ILD disease activity and severity may be confounded by non-pulmonary comorbidities. The Connective Tissue Disease associated Interstitial Lung Disease (CTD-ILD) working group of Outcome Measures in Rheumatology-a non-profit international organisation dedicated to consensus methodology in identification of outcome measures-conducted a series of investigations which included a Delphi process including >248 ILD medical experts as well as patient focus groups culminating in a nominal group panel of ILD experts and patients. The goal was to define and develop a consensus on the status of outcome measure candidates for use in randomised controlled trials in CTD-ILD and idiopathic pulmonary fibrosis (IPF). A core set comprising specific measures in the domains of lung physiology, lung imaging, survival, dyspnoea, cough and health-related quality of life is proposed as appropriate for consideration for use in a hypothetical 1-year multicentre clinical trial for either CTD-ILD or IPF. As many widely used instruments were found to lack full validation, an agenda for future research is proposed. Identification of consensus preliminary domains and instruments to measure them was attained and is a major advance anticipated to facilitate multicentre RCTs in the field.

  2. Core Outcome Sets and Multidimensional Assessment Tools for Harmonizing Outcome Measure in Chronic Pain and Back Pain

    Directory of Open Access Journals (Sweden)

    Ulrike Kaiser

    2016-08-01

    Full Text Available Core Outcome Sets (COSs are a set of domains and measurement instruments recommended for application in any clinical trial to ensure comparable outcome assessment (both domains and instruments. COSs are not exclusively recommended for clinical trials, but also for daily record keeping in routine care. There are several COS recommendations considering clinical trials as well as multidimensional assessment tools to support daily record keeping in low back pain. In this article, relevant initiatives will be described, and implications for research in COS development in chronic pain and back pain will be discussed.

  3. Core Outcome Sets and Multidimensional Assessment Tools for Harmonizing Outcome Measure in Chronic Pain and Back Pain

    Science.gov (United States)

    Kaiser, Ulrike; Neustadt, Katrin; Kopkow, Christian; Schmitt, Jochen; Sabatowski, Rainer

    2016-01-01

    Core Outcome Sets (COSs) are a set of domains and measurement instruments recommended for application in any clinical trial to ensure comparable outcome assessment (both domains and instruments). COSs are not exclusively recommended for clinical trials, but also for daily record keeping in routine care. There are several COS recommendations considering clinical trials as well as multidimensional assessment tools to support daily record keeping in low back pain. In this article, relevant initiatives will be described, and implications for research in COS development in chronic pain and back pain will be discussed. PMID:27589816

  4. Development of a core set of SNP markers for the identiifcation of upland cotton cultivars in China

    Institute of Scientific and Technical Information of China (English)

    KUANG Meng; WEI Shou-jun; WANG Yan-qin; ZHOU Da-yun; MA Lei; FANG Dan; YANG Wei-hua; MA Zhi-ying

    2016-01-01

    Considering the advantages of single nucleotide polymorphisms (SNP) in genotyping and variety identiifcation, the ifrst set public SNP markers at Cotton Marker Database (http://www.cottonmarker.org/) were validated and screened across standard varieties of cotton distinctness, uniformity and stability (DUS) test, aiming to obtain an appropriate set of core SNP markers suitable for upland cotton cultivars in China. A total of 399 out of 1005 SNPs from 270 loci including 170 insertions-dele-tions (InDels) were evaluated for their polymorphisms among 30 standard varieties using Sanger sequencing. As a result, 147 loci were sequenced successfuly, 377 SNPs and 49 InDels markers were obtained. Among the 377 SNP markers, 333 markers (88.3%) were polymorphic betweenGossypium hirsutum andG. barbadense, while 164 markers (43.5%) were polymorphic within upland cotton. As for InDel markers, the polymorphic rate is relatively lower than that of SNP both between species and within species. The homozygous DNA locus ratio of 121 SNPs was higher than 86.2% while that of other 43 SNPs was less than 70%. Only 64 SNPs displayed completely homozygous genotypes among al of the detected upland cotton varieties with 100% homozygous DNA locus ratio. At last, a set of 23 pairs of core SNPs were achieved in view of avoidance of linkage, with polymorphism information content (PIC) values varying from 0.21 to 0.38 with an average of 0.28. Genotype characteristics and genetic diversity were analyzed based on the set of core markers, while 40 pairs of core simple-sequence repeats (SSR) primers comprised of 10 sets of four multiplex PCR combinations were also used for analysis based on lfuorescence detection system. Comparison results indicated that the genetic diversity level was almost equal, while various varieties were signiifcantly different from each other. Genetic relationship revealed by SSR markers is related to geographic source to a certain extent. Meanwhile clustering results analyzed

  5. Preliminary evaluation of a 99mTc labeled hybrid nanoparticle bearing a cobalt ferrite core: in vivo biodistribution.

    Science.gov (United States)

    Psimadas, Dimitrios; Baldi, Giovanni; Ravagli, Costanza; Bouziotis, Penelope; Xanthopoulos, Stavros; Franchini, Mauro Comes; Georgoulias, Panagiotis; Loudos, George

    2012-08-01

    Magnetic nanoparticles have become important tools for imaging a wide range of diseases, improving drug delivery and applying hyperthermic treatment. Iron oxide based nanoparticles have been widely examined, unlike cobalt ferrite based ones. Herein, monodisperse and stable CoFe2O4 nanoparticles have been produced, coated and further stabilized using ethyl 12-(hydroxyamino)-12-oxododecanoate, poly(lactic-co-glycolic acid) and bovine serum albumin. The final product, NBRh1, was fully characterized and has been directly radiolabeled with 99mTc using SnCl1 as the reducing agent in high yields. In vitro stability and hyperthermic properties of 99mTC-NBRh1 were encouraging for further application in low frequencies hyperthermia and biomagnetic applications. In vivo evaluation followed after injection in healthy mice. The planar and SPECT imaging data as well as the biodistribution results were in accordance, showing high liver and spleen uptake as expected starting almost immediately after administration. In conclusion the preliminary results for nanoparticles bearing a cobalt ferrite core justify further investigations towards potential hyperthermic applications, drug transportation and liver or spleen imaging.

  6. ISP: an optimal out-of-core image-set processing streaming architecture for parallel heterogeneous systems.

    Science.gov (United States)

    Ha, Linh Khanh; Krüger, Jens; Dihl Comba, João Luiz; Silva, Cláudio T; Joshi, Sarang

    2012-06-01

    Image population analysis is the class of statistical methods that plays a central role in understanding the development, evolution, and disease of a population. However, these techniques often require excessive computational power and memory that are compounded with a large number of volumetric inputs. Restricted access to supercomputing power limits its influence in general research and practical applications. In this paper we introduce ISP, an Image-Set Processing streaming framework that harnesses the processing power of commodity heterogeneous CPU/GPU systems and attempts to solve this computational problem. In ISP, we introduce specially designed streaming algorithms and data structures that provide an optimal solution for out-of-core multiimage processing problems both in terms of memory usage and computational efficiency. ISP makes use of the asynchronous execution mechanism supported by parallel heterogeneous systems to efficiently hide the inherent latency of the processing pipeline of out-of-core approaches. Consequently, with computationally intensive problems, the ISP out-of-core solution can achieve the same performance as the in-core solution. We demonstrate the efficiency of the ISP framework on synthetic and real datasets.

  7. Off-line mapping of multi-rate dependent task sets to many-core platforms

    DEFF Research Database (Denmark)

    Puffitsch, Wolfgang; Noulard, Eric; Pagetti, Claire

    2015-01-01

    model to safely execute dependent periodic task sets on these platforms. The four rules of the execution model entail that an off-line mapping of the application to the platform must be computed. The paper details our approach to automatically compute a valid mapping. Furthermore, we evaluate our...... approach, which is based on constraint programming, by applying it to several task sets that are derived from industrial applications....

  8. Setting up The Geological information and modelling Thematic Core Service for EPOS

    Science.gov (United States)

    Grellet, Sylvain; Häner, Rainer; Pedersen, Mikael; Lorenz, Henning; Carter, Mary; Cipolloni, Carlo; Robida, François

    2017-04-01

    Geological data and models are key assets for the EPOS community. The Geological information and modelling Thematic Core Service of EPOS is being designed as an efficient and sustainable access system for geological multi-scale data assets for EPOS through the integration of distributed infrastructure components (nodes) of geological surveys, research institutes and the international drilling community (ICDP/IODP). The TCS will develop and take benefit of the synergy between the existing data infrastructures of the Geological Surveys of Europe (EuroGeoSurveys / OneGeology-Europe / EGDI) and of the large amount of information produced by the research organisations. These nodes will offer a broad range of resources including: geological maps, borehole data, borehole associated observations (borehole log data, groundwater level, groundwater quality…) and archived information on physical material (samples, cores), geological models (3D, 4D), geohazards, geophysical data such as active seismic data and other analyses of rocks, soils and minerals. The services will be implemented based on international standards (such as INSPIRE, IUGS/CGI, OGC, W3C, ISO) in order to guarantee their interoperability with other EPOS TCS as well as their compliance with INSPIRE European Directive or international initiatives (such as OneGeology). We present the implementation of the thematic core services for geology and modelling, including scheduling of the development of the different components. The activity with the OGC groups already started in 2016 through an ad-hoc meeting on Borehole and 3D/4D and the way both will be interlinked will also be introduced. This will provide future virtual research environments with means to facilitate the use of existing information for future applications. In addition, workflows will be established that allow the integration of other existing and new data and applications. Processing and the use of simulation and visualization tools will

  9. Student Evaluation of Teaching (SET in Web-based Classes: Preliminary Findings and a Call for Further Research

    Directory of Open Access Journals (Sweden)

    Karen A. Loveland

    2007-07-01

    Full Text Available Student evaluation of teaching (SET is important to faculty because SET ratings help faculty improve performance and are often used as the basis for evaluations of teaching effectiveness in administrative decisions (e.g., tenure. Researchers have conducted over 2,000 studies on SET during the past 70 years. However, despite the explosive growth in online education during the past decade, researchers have largely neglected the use of SET to evaluate teaching effectiveness in online courses. This exploratory study analyzed the actual SET data collected during a single semester at a large mid-western college that offers over 250 online/Web-based classes. The data included five dependent and eighteen independent measures of teaching effectiveness. The results indicate that average SET ratings in online classes are significantly lower than the average ratings in on-campus classes across all five dependent measures. This finding offers preliminary empirical support for anecdotal evidence cited by earlier authors in this field. Furthermore, regression analysis of the full model for each dependent variable indicated that the independent variables explained a significant portion of the variance in SET ratings. Examination of the standardized beta coefficients revealed that the strength and significance of the independent variables varied across the five dependent measures. Findings also indicate that organization of the course materials had a strong impact on all five measures of overall teaching effectiveness. Other variables including clarity of the instructor’s writing, timeliness in providing feedback, and interest in whether students learned were also significant factors in models that measured instructor effectiveness (as opposed to models that measured quality of course content. The paper concludes with a discussion of the implications of this study for administrators, faculty, and researchers.

  10. Preliminary evaluation of pollen quality, fertility relations and fruit set of selected sour cherry cultivars in polish conditions

    Directory of Open Access Journals (Sweden)

    Ewa Szpadzik

    2012-12-01

    Full Text Available Preliminary experiments were carried out in spring 2006. The percentage of fruit set of 'Schattenmorelle IR-2', 'Koral', 'Debreceni Bötermö', 'újfefértói Fürtos' and 'Karneol' was higher after open pollination compared with self-pollination. The cultivar Vowi had an inconsiderably higher percentage of fruit set after self-pollination compared with open pollination. The percentage of fruit set in 'Debreceni Bötermö' and 'újfehértói Fürtos' was about 25 % higher after pollination by 'Schattenmorelle IR-2' and 'Koral' compared with the percentage of fruit set after cross - pollination of both cultivars with each other. In general, they did not appear to be good pollinators with each other. The highest quality of pollen was observed for the following cultivars: 'Schattenmorelle IR-2', 'Koral' and Vowi and the lowest result was obtained in 'újfehértói Fürtos'. The highest yield was given by the following cultivars: Vowi, Schattenmorelle IR-2 and Koral.

  11. Report from the kick-off meeting of the Cochrane Skin Group Core Outcome Set Initiative (CSG-COUSIN).

    Science.gov (United States)

    Schmitt, J; Deckert, S; Alam, M; Apfelbacher, C; Barbaric, J; Bauer, A; Chalmers, J; Chosidow, O; Delamere, F; Doney, E; Eleftheriadou, V; Grainge, M; Johannsen, L; Kottner, J; Le Cleach, L; Mayer, A; Pinart, M; Prescott, L; Prinsen, C A C; Ratib, S; Schlager, J G; Sharma, M; Thomas, K S; Weberschock, T; Weller, K; Werner, R N; Wild, T; Wilkes, S R; Williams, H C

    2016-02-01

    A major obstacle of evidence-based clinical decision making is the use of nonstandardized, partly untested outcome measurement instruments. Core Outcome Sets (COSs) are currently developed in different medical fields to standardize and improve the selection of outcomes and outcome measurement instruments in clinical trials, in order to pool results of trials or to allow indirect comparison between interventions. A COS is an agreed minimum set of outcomes that should be measured and reported in all clinical trials of a specific disease or trial population. The international, multidisciplinary Cochrane Skin Group Core Outcome Set Initiative (CSG-COUSIN) aims to develop and implement COSs in dermatology, thus making trial evidence comparable and, herewith, more useful for clinical decision making. The inaugural meeting of CSG-COUSIN was held on 17-18 March 2015 in Dresden, Germany, as the exclusive theme of the Annual Cochrane Skin Group Meeting. In total, 29 individuals representing a broad mix of different stakeholder groups, professions, skills and perspectives attended. This report provides a description of existing COS initiatives in dermatology, highlights current methodological challenges in COS development, and presents the concept, aims and structure of CSG-COUSIN.

  12. Preliminary design of axial flow hydrocarbon turbine/generator set for geothermal applications

    Energy Technology Data Exchange (ETDEWEB)

    Barnes, B.; Samurin, N.A.; Shields, J.R.

    1979-05-01

    This report outlines the design of a 65 MW (e) gross turbine generator set in which a hydrocarbon gas mixture is used as the motive fluid. The turbine generator set is part of a geothermal binary cycle electric power plant proposed for the Heber site in the Imperial Valley, California. Aerodynamic design considerations and estimated unit performance for three hydrocarbon gas mixtures are presented. Real gas properties and equations of state are reviewed as they affect the turbine design and the thermodynamic cycle. The mechanical designs for the casing, rotor dynamics, shaft sealing and unit construction are detailed. Support systems such as the lube and seal supply system, turbine controls, etc., are reviewed. An extensive hydrocarbon turbine general specification is also included.

  13. Core Measures for Congestive Heart Failure in a Tertiary Care Setting in Pakistan

    Science.gov (United States)

    Zafar, Rizwan; Haris, Muhammad; Shabbir, Muhammad Usman; Ghazanfar, Haider; Malik, Sarah A; Khalid, Tehreem; Abbas, Ali H; Saleem, Asad A

    2016-01-01

    Purpose: Heart failure presents a huge burden for individual patients and the healthcare system as a whole. This study aims to assess the adherence to these core measures as identified by the Joint Commission on Accreditation of Healthcare Organizations (JCAHO)/ American Heart Association (AHA) by physicians of Pakistan. Materials and Methodology: We conducted a cross-sectional study in Shifa International Hospital, Islamabad, Pakistan from the period of April 2013 to April 2016. Patients with a primary diagnosis of heart failure were drawn from a coding section of hospital’s record department. Data was evaluated to assess how strictly doctors were following core measures identified by JCAHO/AHA for the given diagnosis. Inclusion criteria for this study were patients ≥ 17 years of age and patients with a primary diagnosis of heart failure according to New York Heart Association (NYHA) classification. Patients with congenital anomalies and structural heart wall problems, like sarcoidosis, hemochromatosis, and amyloidosis, were excluded from the study. Results: Mean ejection fraction (EF) was found to be 27.23 ± 11.72 percent. Symptoms assessment of heart failure was done in 16/421 (3.8%) patients according to NYHA classification and in 405/421 (96.2%) patients according to outpatient-based heart failure assessment based on physician's experience other than NYHA classification. Left ventricle ejection fraction (LVEF) was assessed in 411/421 (97%) patients. Out of these, 336/411 (81.7%) patients had EF < 40%. Mean EF was found to be significantly higher in females as compared to males (p < 0.001). Three hundred and thirty-six out of 411 (81.7%) patients with EF < 40% needed angiotensin converting enzyme inhibitors (ACEi) and beta-blocker (BB) prescriptions. ACEi were prescribed only to 230/336 (68.7%) patients and 248/336 (73.8%) patients were given BB with documented contraindication to ACEi and BB in 7.36% and 17% patients, respectively. There was no

  14. Genome-Wide Temporal Expression Profiling in Caenorhabditis elegans Identifies a Core Gene Set Related to Long-Term Memory.

    Science.gov (United States)

    Freytag, Virginie; Probst, Sabine; Hadziselimovic, Nils; Boglari, Csaba; Hauser, Yannick; Peter, Fabian; Gabor Fenyves, Bank; Milnik, Annette; Demougin, Philippe; Vukojevic, Vanja; de Quervain, Dominique J-F; Papassotiropoulos, Andreas; Stetak, Attila

    2017-07-12

    The identification of genes related to encoding, storage, and retrieval of memories is a major interest in neuroscience. In the current study, we analyzed the temporal gene expression changes in a neuronal mRNA pool during an olfactory long-term associative memory (LTAM) in Caenorhabditis elegans hermaphrodites. Here, we identified a core set of 712 (538 upregulated and 174 downregulated) genes that follows three distinct temporal peaks demonstrating multiple gene regulation waves in LTAM. Compared with the previously published positive LTAM gene set (Lakhina et al., 2015), 50% of the identified upregulated genes here overlap with the previous dataset, possibly representing stimulus-independent memory-related genes. On the other hand, the remaining genes were not previously identified in positive associative memory and may specifically regulate aversive LTAM. Our results suggest a multistep gene activation process during the formation and retrieval of long-term memory and define general memory-implicated genes as well as conditioning-type-dependent gene sets.SIGNIFICANCE STATEMENT The identification of genes regulating different steps of memory is of major interest in neuroscience. Identification of common memory genes across different learning paradigms and the temporal activation of the genes are poorly studied. Here, we investigated the temporal aspects of Caenorhabditis elegans gene expression changes using aversive olfactory associative long-term memory (LTAM) and identified three major gene activation waves. Like in previous studies, aversive LTAM is also CREB dependent, and CREB activity is necessary immediately after training. Finally, we define a list of memory paradigm-independent core gene sets as well as conditioning-dependent genes. Copyright © 2017 the authors 0270-6474/17/376661-12$15.00/0.

  15. Developing a Core Set of Outcome Measures for Behçet Disease: Report from OMERACT 2016.

    Science.gov (United States)

    Hatemi, Gulen; Meara, Alexa; Ozguler, Yesim; Direskeneli, Haner; Mahr, Alfred; Easley, Ebony; Gurcan, Mert; Davis, Trocon; Gul, Ahmet; Yazici, Yusuf; Zottenberg, Katelyn; Esatoglu, Sinem Nihal; Erer, Burak; Kamali, Sevil; Yazici, Hasan; Cronholm, Peter F; Merkel, Peter A

    2017-04-01

    The Outcome Measures in Rheumatology (OMERACT) Vasculitis Working Group has been working toward developing a data-driven core set of outcome measures for use in clinical trials of Behçet's syndrome [Behçet disease (BD)]. This paper summarizes the group's work through OMERACT 2016, discussions during the meeting, and the future research agenda. Qualitative patient interviews were conducted among 20 patients with BD who have different types of organ involvement. A 3-round Delphi among BD experts and patients was initiated to identify domains, subdomains, and outcomes to be assessed in clinical trials of BD. The results of these studies were discussed during OMERACT 2016 and next steps were planned. Patients' perspectives and priorities were identified through qualitative interviews that identified candidate domains and subdomains for inclusion in the Delphi and characterized some shortcomings of the currently used patient-reported outcomes in BD. The first round of the Delphi was completed and several domains or subdomains were endorsed by the experts and/or the patients. Because many more items were endorsed than would be feasible to assess during a clinical trial, rating and ranking of items by physicians and patients was planned as a next critical step. The challenges of assessing specific organ system involvement was also discussed. The OMERACT Behçet Syndrome Working Group research program will identify core domains for assessment in BD with the goal of developing a core set of outcome measures for use in all trials of BD with the option to incorporate additional outcomes for specific organ involvement.

  16. Feasibility and Domain Validation of Rheumatoid Arthritis (RA) Flare Core Domain Set

    DEFF Research Database (Denmark)

    Bartlett, Susan J; Bykerk, Vivian P; Cooksey, Roxanne

    2015-01-01

    OBJECTIVE: The Outcome Measures in Rheumatology (OMERACT) Rheumatoid Arthritis (RA) Flare Group was established to develop an approach to identify and measure RA flares. An overview of our OMERACT 2014 plenary is provided. METHODS: Feasibility and validity of flare domains endorsed at OMERACT 11...... (2012) were described based on initial data from 3 international studies collected using a common set of questions specific to RA flare. Mean flare frequency, severity, and duration data were presented, and domain scores were compared by flare status to examine known-groups validity. Breakout groups......, and stiffness scores averaged ≥ 2 times higher (2 of 11 points) in flaring individuals. Correlations between flare domains and corresponding legacy instruments were obtained: r = 0.46 to 0.93. A combined definition (patient report of flare and 28-joint Disease Activity Score increase) was evaluated in 2 other...

  17. Comparing simple root phenotyping methods on a core set of rice genotypes.

    Science.gov (United States)

    Shrestha, R; Al-Shugeairy, Z; Al-Ogaidi, F; Munasinghe, M; Radermacher, M; Vandenhirtz, J; Price, A H

    2014-05-01

    Interest in belowground plant growth is increasing, especially in relation to arguments that shallow-rooted cultivars are efficient at exploiting soil phosphorus while deep-rooted ones will access water at depth. However, methods for assessing roots in large numbers of plants are diverse and direct comparisons of methods are rare. Three methods for measuring root growth traits were evaluated for utility in discriminating rice cultivars: soil-filled rhizotrons, hydroponics and soil-filled pots whose bottom was sealed with a non-woven fabric (a potential method for assessing root penetration ability). A set of 38 rice genotypes including the OryzaSNP set of 20 cultivars, additional parents of mapping populations and products of marker-assisted selection for root QTLs were assessed. A novel method of image analysis for assessing rooting angles from rhizotron photographs was employed. The non-woven fabric was the easiest yet least discriminatory method, while the rhizotron was highly discriminatory and allowed the most traits to be measured but required more than three times the labour of the other methods. The hydroponics was both easy and discriminatory, allowed temporal measurements, but is most likely to suffer from artefacts. Image analysis of rhizotrons compared favourably to manual methods for discriminating between cultivars. Previous observations that cultivars from the indica subpopulation have shallower rooting angles than aus or japonica cultivars were confirmed in the rhizotrons, and indica and temperate japonicas had lower maximum root lengths in rhizotrons and hydroponics. It is concluded that rhizotrons are the preferred method for root screening, particularly since root angles can be assessed.

  18. A experiência brasileira com o core set da classificação internacional de funcionalidade, incapacidade e saúde para lombalgia La experiencia brasileña con el core set de la clasificación internacional de funcionalidad, incapacidad y salud para dorsalgia The Brazilian experience with the international classification of functioning, disability and health core set for low back pain

    Directory of Open Access Journals (Sweden)

    Marcelo Riberto

    2011-01-01

    Full Text Available OBJETIVO: Validar empiricamente o core set da CIF para lombalgia e descrever a funcionalidade de uma amostra de pacientes com lombalgia mecânica crônica inespecífica. MÉTODOS: Vinte e nove pacientes de um centro de reabilitação foram avaliados por meio do core set da CIF para lombalgia e pelo questionário de Roland Morris (QRM e SF-36. RESULTADOS: Todas as categorias de estruturas do corpo do core set se mostraram comprometidas em ao menos 80% dos pacientes, sendo consideradas validadas. Entre as 19 categorias de Funções do corpo, apenas quatro estavam comprometidas em menos que 80% dos pacientes, sendo consideradas não-validadas, o mesmo foi observado para cinco das 29 de Atividades e participações e cinco das 25 categorias de Fatores ambientais. CONCLUSÕES: As categorias selecionadas para o core set da CIF para lombalgia foram consideradas empiricamente validadas e em conjunto permitiram descrever a multiplicidade de repercussões dessa condição de saúde sobre a funcionalidade das pessoas. O core set da CIF serve para guiar a intervenção terapêutica interdisciplinar.OBJETIVO: Validar empíricamente el core set de la CIF para dorsalgia y describir la funcionalidad de una muestra de pacientes con dorsalgia mecánica crónica inespecífica. MÉTODOS: Veintinueve pacientes de un centro de rehabilitación fueron evaluados por medio del core set de la CIF para dorsalgia, y mediante el cuestionario Roland Moris (QRM y SF-36. RESULTADOS: Todas las categorías de Estructuras del cuerpo del core set se mostraron comprometidas en por lo menos 80% de los pacientes, siendo consideradas validadas. Entre las 19 categorías de Funciones del cuerpo, sólo cuatro estaban comprometidas en menos de 80% de los pacientes, siendo consideradas como no validadas; lo mismo fue observado para 5 de las 29 categorías de Actividades y participaciones, y 5 de las 25 categorías de Factores ambientales. CONCLUSIONES: Las categorías seleccionadas para el

  19. Validation of the Comprehensive ICF Core Set for Stroke by exploring the patient's perspective on functioning in everyday life: a qualitative study.

    Science.gov (United States)

    Paanalahti, Markku; Alt Murphy, Margit; Lundgren-Nilsson, Åsa; Sunnerhagen, Katharina S

    2014-12-01

    International Classification of Functioning, Disability and Health (ICF) core sets are short procedures to record and provide information on health. However, further validation is needed. The aim of this study was to validate the Comprehensive ICF Core Set for stroke by exploring the patient's living at home and receiving outpatient rehabilitation perspective on functioning in everyday life. Qualitative interviews of 22 patients with previous stroke in Finland were analyzed using the content analysis method: functional concepts that described the participants' perspective on functioning in everyday life were extracted from the interview transcripts and linked to ICF categories using ICF linking rules. Extracted functional concepts from 372 meaning units were linked to 115 of the 166 categories included in the Comprehensive ICF Core Set for stroke and to six additional ICF categories. Thirty-eight concepts could not be linked to the ICF categories. Sixty-eight percent of the second-level ICF categories in the Comprehensive ICF Core Set for stroke were validated. In total, 28 of 36 categories added to the Comprehensive ICF Core Set for stroke from the Core Sets for patients with neurological conditions in the acute and early postacute phases were not confirmed in this sample of individuals with stroke living in their homes.

  20. Comparative genomic analysis of the family Iridoviridae: re-annotating and defining the core set of iridovirus genes

    Directory of Open Access Journals (Sweden)

    Upton Chris

    2007-01-01

    Full Text Available Abstract Background Members of the family Iridoviridae can cause severe diseases resulting in significant economic and environmental losses. Very little is known about how iridoviruses cause disease in their host. In the present study, we describe the re-analysis of the Iridoviridae family of complex DNA viruses using a variety of comparative genomic tools to yield a greater consensus among the annotated sequences of its members. Results A series of genomic sequence comparisons were made among, and between the Ranavirus and Megalocytivirus genera in order to identify novel conserved ORFs. Of these two genera, the Megalocytivirus genomes required the greatest number of altered annotations. Prior to our re-analysis, the Megalocytivirus species orange-spotted grouper iridovirus and rock bream iridovirus shared 99% sequence identity, but only 82 out of 118 potential ORFs were annotated; in contrast, we predict that these species share an identical complement of genes. These annotation changes allowed the redefinition of the group of core genes shared by all iridoviruses. Seven new core genes were identified, bringing the total number to 26. Conclusion Our re-analysis of genomes within the Iridoviridae family provides a unifying framework to understand the biology of these viruses. Further re-defining the core set of iridovirus genes will continue to lead us to a better understanding of the phylogenetic relationships between individual iridoviruses as well as giving us a much deeper understanding of iridovirus replication. In addition, this analysis will provide a better framework for characterizing and annotating currently unclassified iridoviruses.

  1. International classification of functioning, disability, and health core sets for hearing loss: a discussion paper and invitation.

    Science.gov (United States)

    Danermark, Berth; Cieza, Alarcos; Gangé, Jean-Pierre; Gimigliano, Francesca; Granberg, Sarah; Hickson, Louise; Kramer, Sophia E; McPherson, Bradley; Möller, Claes; Russo, Ieda; Strömgren, Jan Peter; Stucki, Gerold; Swanepoel, Dewet

    2010-04-01

    The World Health Organization's International Classification of Functioning, Disability and Health (ICF) has adopted a multifactorial understanding of functioning and disability, merging a biomedical paradigm with a social paradigm into a wider understanding of human functioning. Altogether there are more than 1400 ICF-categories describing different aspects of human functioning and there is a need to developing short lists of ICF categories to facilitate use of the classification scheme in clinical practice. To our knowledge, there is currently no such standard measuring instrument to facilitate a common validated way of assessing the effects of hearing loss on the lives of adults. The aim of the project is the development of an internationally accepted, evidence-based, reliable, comprehensive and valid ICF Core Sets for Hearing Loss. The processes involved in this project are described in detail and the authors invite stakeholders, clinical experts and persons with hearing loss to actively participate in the development process.

  2. A preliminary study on the behavior of trace elements in sediment cores from Ilha Grande (Rio de Janeiro State) by neutron activation analysis

    Energy Technology Data Exchange (ETDEWEB)

    Wasserman, Julio Cesar [Universidade Federal Fluminense, Niteroi, RJ (Brazil). Dept. de Geoquimica; Figueiredo, Ana Maria G. [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil); Figueira, Andre Luiz [Universidade do Estado, Rio de Janeiro, RJ (Brazil). Dept. de Oceanografia; Kelecom, Alphonse [Universidade Federal Fluminense, Niteroi, RJ (Brazil). Dept. de Biologia Geral

    2002-07-01

    The present work aims to identify atmospheric and marine inputs of 9 metals (Ba, Co, Cr, Cs, Fe, Hf, Rb, Sc, Zn), 8 rare earths (La, Ce, Nd, Sm, Eu, Tb, Yb e Lu), 2 actinides (U, Th) and 3 non-metals (As, Sb, Se) in sediment cores from a remote area, the Biological Reserve of Praia do Sul, Ilha Grande, Rio de Janeiro, Brazil. The sediment cores were sampled in a peat bog (out of the tidal reach) and in a mangrove, downstream of the peat bog. The analytical technique employed was Instrumental Neutron Activation Analysis. The samples were irradiated for 16 hours at a thermal neutron flux of 10{sup 12} n cm{sup -2} s{sup -1} at the IEA-R1 reactor of IPEN. The measurements of the induced gamma-ray activity were carried out by high resolution gamma spectrometry, with an hyperpure Ge detector. A preliminary sediment dating with Po-210 was also carried out by applying radiochemical procedures and measurements were done in an Alfa spectrometer The results indicate that the peat bog core present a slight surface enrichment that can be attributed to atmospheric inputs. Increasing concentrations of metals with age is probably due to history of soil occupation. In the mangrove core, no significant increase in concentration could be detected in the surface sediments (except for Zn) confirming the suitability of the peat bog core as a tracer for atmospheric inputs. (author)

  3. The Geriatric ICF Core Set reflecting health-related problems in community-living older adults aged 75 years and older without dementia: development and validation.

    Science.gov (United States)

    Spoorenberg, Sophie L W; Reijneveld, Sijmen A; Middel, Berrie; Uittenbroek, Ronald J; Kremer, Hubertus P H; Wynia, Klaske

    2015-01-01

    The aim of the present study was to develop a valid Geriatric ICF Core Set reflecting relevant health-related problems of community-living older adults without dementia. A Delphi study was performed in order to reach consensus (≥70% agreement) on second-level categories from the International Classification of Functioning, Disability and Health (ICF). The Delphi panel comprised 41 older adults, medical and non-medical experts. Content validity of the set was tested in a cross-sectional study including 267 older adults identified as frail or having complex care needs. Consensus was reached for 30 ICF categories in the Delphi study (fourteen Body functions, ten Activities and Participation and six Environmental Factors categories). Content validity of the set was high: the prevalence of all the problems was >10%, except for d530 Toileting. The most frequently reported problems were b710 Mobility of joint functions (70%), b152 Emotional functions (65%) and b455 Exercise tolerance functions (62%). No categories had missing values. The final Geriatric ICF Core Set is a comprehensive and valid set of 29 ICF categories, reflecting the most relevant health-related problems among community-living older adults without dementia. This Core Set may contribute to optimal care provision and support of the older population. Implications for Rehabilitation The Geriatric ICF Core Set may provide a practical tool for gaining an understanding of the relevant health-related problems of community-living older adults without dementia. The Geriatric ICF Core Set may be used in primary care practice as an assessment tool in order to tailor care and support to the needs of older adults. The Geriatric ICF Core Set may be suitable for use in multidisciplinary teams in integrated care settings, since it is based on a broad range of problems in functioning. Professionals should pay special attention to health problems related to mobility and emotional functioning since these are the most

  4. A methodological approach for assessing the uptake of core outcome sets using ClinicalTrials.gov: findings from a review of randomised controlled trials of rheumatoid arthritis.

    Science.gov (United States)

    Kirkham, Jamie J; Clarke, Mike; Williamson, Paula R

    2017-05-17

    Objective To assess the uptake of the rheumatoid arthritis core outcome set using a new assessment method of calculating uptake from data in clinical trial registry entries.Design Review of randomised trials.Setting ClinicalTrials.gov.Subjects 273 randomised trials of drug interventions for the treatment of rheumatoid arthritis and registered in ClinicalTrials.gov between 2002 and 2016. Full publications were identified for completed studies from information in the trial registry or from an internet search using Google and the citation database Web of Science.Main outcome measure The percentage of trials reporting or planning to measure the rheumatoid arthritis core outcome set calculated from the information presented in the trial registry and compared with the percentage reporting the rheumatoid arthritis core outcome set in the resulting trial publications.Results The full rheumatoid arthritis core outcome set was reported in 81% (116/143) of trials identified on the registry as completed (or terminated) for which results were found in either the published literature or the registry. For trials identified on the registry as completed (or terminated), using information only available in the registry gives an estimate for uptake of 77% (145/189).Conclusions The uptake of the rheumatoid arthritis core outcome set in clinical trials has continued to increase over time. Using the information on outcomes listed for completed or terminated studies in a trial registry provides a reasonable estimate of the uptake of a core outcome set and is a more efficient and up-to-date approach than examining the outcomes in published trial reports. The method proposed may provide an efficient approach for an up-to-date assessment of the uptake of the 300 core outcome sets already published. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  5. Content validation of the international classification of functioning, disability and health core set for stroke from gender perspective using a qualitative approach.

    Science.gov (United States)

    Glässel, A; Coenen, M; Kollerits, B; Cieza, A

    2014-06-01

    The extended ICF Core Set for stroke is an application of the International Classification of Functioning, Disability and Health (ICF) of the World Health Organisation (WHO) with the purpose to represent the typical spectrum of functioning of persons with stroke. The objective of the study is to add evidence to the content validity of the extended ICF Core Set for stroke from persons after stroke taking into account gender perspective. A qualitative study design was conducted by using individual interviews with women and men after stroke in an in- and outpatient rehabilitation setting. The sampling followed the maximum variation strategy. Sample size was determined by saturation. Concepts from qualitative data analysis were linked to ICF categories and compared to the extended ICF Core Set for stroke. Twelve women and 12 men participated in 24 individual interviews. In total, 143 out of 166 ICF categories included in the extended ICF Core Set for stroke were confirmed (women: N.=13; men: N.=17; both genders: N.=113). Thirty-eight additional categories that are not yet included in the extended ICF Core Set for stroke were raised by women and men. This study confirms that the experience of functioning and disability after stroke shows communalities and differences for women and men. The validity of the extended ICF Core Set for stroke could be mostly confirmed, since it does not only include those areas of functioning and disability relevant to both genders but also those exclusively relevant to either women or men. Further research is needed on ICF categories not yet included in the extended ICF Core Set for stroke.

  6. Validation of the ICF Core Set for Vocational Rehabilitation from the perspective of patients with spinal cord injury using focus groups.

    Science.gov (United States)

    Aiachini, Beatrice; Cremascoli, Sonia; Escorpizo, Reuben; Pistarini, Caterina

    2016-01-01

    The International Classification of Functioning, Disability and Health (ICF) Core Set for Vocational Rehabilitation is an application of the ICF of the World Health Organization with the purpose of identifying problems and resources relevant for people in a vocational rehabilitation given a health condition. The objective of the study was to validate the Comprehensive ICF Core Set for Vocational Rehabilitation from the perspective of patients with spinal cord injury (SCI). The specific aims were to explore the aspects of functioning and health important to patients with SCI regarding return to work and to examine to what extent these aspects are represented by the current version of the Comprehensive ICF Core Set for Vocational Rehabilitation. Focus group interviews were conducted. The sampling of patients followed the maximum variation strategy. Sample size satisfied saturation criterion. The focus groups were digitally recorded and transcribed verbatim. The meaning condensation procedure was used for the data analysis. After qualitative data analysis, the resulting concepts were linked to ICF categories according to established linking rules. Twenty-four SCI patients participated in seven focus groups. Sixty-three ICF categories out of 90 ICF categories contained in the Comprehensive ICF Core Set for Vocational Rehabilitation were reported by the patients. Forty-two additional categories that are not covered in the Comprehensive ICF Core Set for Vocational Rehabilitation were found but adding the health condition-specific ICF Core Set for SCI in long-term context, only 11 categories were not covered. The existing version of the Comprehensive ICF Core Set for Vocational Rehabilitation was confirmed almost entirely by the focus groups to explore the vocational situation of patients with SCI. Implications for Rehabilitation Validation of the ICF Core Set for Vocational Rehabilitation as a useful tool to facilitate social reintegration and rehabilitation of patients

  7. [Can ICF core sets be helpful in preparing a social-medical expert report due to incapacity to work?--a first proposal].

    Science.gov (United States)

    Kirschneck, M; Legner, R; Armbrust, W; Nowak, D; Cieza, A

    2015-04-01

    Social-medical expert reports from the German statutory pension insurance are essential for the German statutory pension regulatory authority to decide whether to grant services regarding participation as well as retirement pensions due to incapacity to work.The objective of this investigation is to determine whether the ICF Core Sets and other international approaches, such as the EUMASS Core Sets or ICF Core Set for vocational rehabilitation cover the content of the social-medical expert reports as well as to propose an approach how the ICF can be economically used by the social medicine practitioner when writing a social-medical expert report. A retrospective quantitative study design was used to translate a total of 294 social-medical expert reports from patients with low back pain (LBP) or chronic widespread pain (CWP) into the language of the ICF (linking) by 2 independent health professionals and compare the results with the ICF Core Sets for specific health conditions and other international approaches. The content of social-medical expert reports was largely reflected by the condition specific brief ICF Core Sets, brief ICF Core Sets for vocational rehabilitation and EUMASS Core Sets. The weighted Kappa statistic for the agreement between the 2 health professionals who translated the expert reports were in CWP 0.69 with a bootstrapped confidence interval of 0.67-0.71 and in LBP 0.73 (0.71-0.74). The analyses show that the content of social-medical expert reports varies enormously. A combination of a condition specific brief ICF Core Set as well as vocational rehabilitation and EUMASS ICF Core Sets as well as all ICF-categories from the expert reports that were named at least in 50% of it can largely provide a basis for preparing expert reports. Within the scope of implementation the need for a specific ICF Core Set for expert reports of the German statutory pension insurance should be further analyzed and discussed. © Georg Thieme Verlag KG Stuttgart

  8. Beyond diagnosis: the Core Sets for persons with schizophrenia based on the World Health Organization's International Classification of Functioning, Disability, and Health.

    Science.gov (United States)

    Gómez-Benito, Juana; Guilera, Georgina; Barrios, Maite; Rojo, Emilio; Pino, Oscar; Gorostiaga, Arantxa; Balluerka, Nekane; Hidalgo, María Dolores; Padilla, José Luis; Benítez, Isabel; Selb, Melissa

    2017-07-30

    Based on the International Classification of Functioning, Disability and Health (ICF), this paper presents the results of the process to develop the Comprehensive and Brief Core Sets for schizophrenia that allow to comprehensively describe functioning in persons with schizophrenia. Twenty health professionals from diverse backgrounds participated in a formal and iterative decision-making process during an international consensus conference to develop these Core Sets. The conference was carried out based on evidence gathered from four preparatory studies (systematic literature review, qualitative study, expert survey, and empirical study). The first step of this decision-making and consensus process comprised of discussions and voting in working groups and plenary sessions to develop the comprehensive version. The categories of the Comprehensive ICF Core Set for schizophrenia served as the basis for the second step -a ranking and cutoff procedure to decide on the brief version. Of the 184 candidate categories identified in the preparatory studies, 97 categories were included in the Comprehensive Core Set for schizophrenia. A total of 25 categories were selected to constitute the Brief Core Set. The formal decision-making and consensus process integrating evidence from four preparatory studies and expert opinion led to the first version of the Core Sets for schizophrenia. Comprehensive and Brief Core Sets for schizophrenia may provide a common language among different health professionals and researchers, and a basic international standard of what to measure, report, and assess the functioning of persons with schizophrenia. Implications for rehabilitation Schizophrenia is a chronic mental disorder that has a tremendous impact on functioning and daily life of persons living with the disorder. The International Classification of Functioning, Disability and Health (ICF) offers an internationally recognized standard for describing the functioning status of these

  9. New Hybrid Multiple Attribute Decision-Making Model for Improving Competence Sets: Enhancing a Company’s Core Competitiveness

    Directory of Open Access Journals (Sweden)

    Kuan-Wei Huang

    2016-02-01

    Full Text Available A company’s core competitiveness depends on the strategic allocation of its human resources in alignment with employee capabilities. Competency models can identify the range of capabilities at a company’s disposal, and this information can be used to develop internal or external education training policies for sustainable development. Such models can ensure the importation of a strategic orientation reflecting the growth of its employee competence set and enhancing human resource sustainably. This approach ensures that the most appropriate people are assigned to the most appropriate positions. In this study, we proposed a new hybrid multiple attributed decision-making model by using the Decision-making trial and Evaluation Laboratory Technique (DEMATEL to construct an influential network relation map (INRM and determined the influential weights by using the basic concept of the analytic network process (called DEMATEL-based ANP, DANP; the influential weights were then adopted with a modified Vise Kriterijumska Optimizacija I Kompromisno Resenje (VIKOR method. A simple forecasting technique as an iteration function was also proposed. The proposed model was effective. We expect that the proposed model can facilitate making timely revisions, reflecting the growth of employee competence sets, reducing the performance gap toward the aspiration level, and ensuring the sustainability of a company.

  10. Transcriptional Differences between Normal and Glioma-Derived Glial Progenitor Cells Identify a Core Set of Dysregulated Genes

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    Romane M. Auvergne

    2013-06-01

    Full Text Available Glial progenitor cells (GPCs are a potential source of malignant gliomas. We used A2B5-based sorting to extract tumorigenic GPCs from human gliomas spanning World Health Organization grades II–IV. Messenger RNA profiling identified a cohort of genes that distinguished A2B5+ glioma tumor progenitor cells (TPCs from A2B5+ GPCs isolated from normal white matter. A core set of genes and pathways was substantially dysregulated in A2B5+ TPCs, which included the transcription factor SIX1 and its principal cofactors, EYA1 and DACH2. Small hairpin RNAi silencing of SIX1 inhibited the expansion of glioma TPCs in vitro and in vivo, suggesting a critical and unrecognized role of the SIX1-EYA1-DACH2 system in glioma genesis or progression. By comparing the expression patterns of glioma TPCs with those of normal GPCs, we have identified a discrete set of pathways by which glial tumorigenesis may be better understood and more specifically targeted.

  11. Characterization of chickpea germplasm conserved in the Indian National Genebank and development of a core set using qualitative and quantitative trait data

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    Sunil Archak

    2016-10-01

    Full Text Available Chickpea is the third most important pulse crop as a source of dietary protein. Ever-increasing demand in Asian countries calls for breeding superior desi-type varieties, in turn necessitating the availability of characterized germplasm to breeders. The Indian National Genebank, located at the National Bureau of Plant Genetic Resources, New Delhi, conserves 14,651 accessions of chickpea. The entire set was characterized in a single large-scale experiment. High variation was observed for eight quantitative and 12 qualitative agro-morphological traits. Allelic richness procedure was employed to assemble a core set comprising 1103 accessions, 70.0% of which were of Indian origin. Comparable values of total variation explained by the first three principal components in the entire collection (51.1% and the core (52.4% together with conservation of nine pairwise r values among quantitative traits in the core collection and a coincidence rate around 99.7% indicated that the chickpea core was indeed an excellent representation of the entire chickpea collection in the National Genebank. The chickpea core exhibited greater diversity than the entire collection in agro-morphological traits, as assessed by higher variance and Shannon–Weaver diversity indices, indicating that the chickpea core maximized the phenotypic diversity available in the Indian chickpea germplasm. The chickpea core, comprising mainly indigenous desi genotypes, is expected to be an excellent resource for chickpea breeders. Information on the chickpea core can be accessed at http://www.nbpgr.ernet.in/pgrportal.

  12. A review of patient and carer participation and the use of qualitative research in the development of core outcome sets.

    Science.gov (United States)

    Jones, Janet E; Jones, Laura L; Keeley, Thomas J H; Calvert, Melanie J; Mathers, Jonathan

    2017-01-01

    To be meaningful, a core outcome set (COS) should be relevant to all stakeholders including patients and carers. This review aimed to explore the methods by which patients and carers have been included as participants in COS development exercises and, in particular, the use and reporting of qualitative methods. In August 2015, a search of the Core Outcomes Measures in Effectiveness Trials (COMET) database was undertaken to identify papers involving patients and carers in COS development. Data were extracted to identify the data collection methods used in COS development, the number of health professionals, patients and carers participating in these, and the reported details of qualitative research undertaken. Fifty-nine papers reporting patient and carer participation were included in the review, ten of which reported using qualitative methods. Although patients and carers participated in outcome elicitation for inclusion in COS processes, health professionals tended to dominate the prioritisation exercises. Of the ten qualitative papers, only three were reported as a clear pre-designed part of a COS process. Qualitative data were collected using interviews, focus groups or a combination of these. None of the qualitative papers reported an underpinning methodological framework and details regarding data saturation, reflexivity and resource use associated with data collection were often poorly reported. Five papers reported difficulty in achieving a diverse sample of participants and two reported that a large and varied range of outcomes were often identified by participants making subsequent rating and ranking difficult. Consideration of the best way to include patients and carers throughout the COS development process is needed. Additionally, further work is required to assess the potential role of qualitative methods in COS, to explore the knowledge produced by different qualitative data collection methods, and to evaluate the time and resources required to

  13. rapidGSEA: Speeding up gene set enrichment analysis on multi-core CPUs and CUDA-enabled GPUs.

    Science.gov (United States)

    Hundt, Christian; Hildebrandt, Andreas; Schmidt, Bertil

    2016-09-23

    Gene Set Enrichment Analysis (GSEA) is a popular method to reveal significant dependencies between predefined sets of gene symbols and observed phenotypes by evaluating the deviation of gene expression values between cases and controls. An established measure of inter-class deviation, the enrichment score, is usually computed using a weighted running sum statistic over the whole set of gene symbols. Due to the lack of analytic expressions the significance of enrichment scores is determined using a non-parametric estimation of their null distribution by permuting the phenotype labels of the probed patients. Accordingly, GSEA is a time-consuming task due to the large number of required permutations to accurately estimate the nominal p-value - a circumstance that is even more pronounced during multiple hypothesis testing since its estimate is lower-bounded by the inverse number of samples in permutation space. We present rapidGSEA - a software suite consisting of two tools for facilitating permutation-based GSEA: cudaGSEA and ompGSEA. cudaGSEA is a CUDA-accelerated tool using fine-grained parallelization schemes on massively parallel architectures while ompGSEA is a coarse-grained multi-threaded tool for multi-core CPUs. Nominal p-value estimation of 4,725 gene sets on a data set consisting of 20,639 unique gene symbols and 200 patients (183 cases + 17 controls) each probing one million permutations takes 19 hours on a Xeon CPU and less than one hour on a GeForce Titan X GPU while the established GSEA tool from the Broad Institute (broadGSEA) takes roughly 13 days. cudaGSEA outperforms broadGSEA by around two orders-of-magnitude on a single Tesla K40c or GeForce Titan X GPU. ompGSEA provides around one order-of-magnitude speedup to broadGSEA on a standard Xeon CPU. The rapidGSEA suite is open-source software and can be downloaded at https://github.com/gravitino/cudaGSEA as standalone application or package for the R framework.

  14. Mapping the rehabilitation interventions of a community stroke team to the extended International Classification of Functioning, Disability and Health Core Set for Stroke.

    Science.gov (United States)

    Evans, Melissa; Hocking, Clare; Kersten, Paula

    2017-12-01

    This study aim was to evaluate whether the Extended International Classification of Functioning, Disability and Health Core Set for Stroke captured the interventions of a community stroke rehabilitation team situated in a large city in New Zealand. It was proposed that the results would identify the contribution of each discipline, and the gaps and differences in service provision to Māori and non-Māori. Applying the Extended International Classification of Functioning, Disability and Health Core Set for Stroke in this way would also inform whether this core set should be adopted in New Zealand. Interventions were retrospectively extracted from 18 medical records and linked to the International Classification of Functioning, Disability and Health and the Extended International Classification of Functioning, Disability and Health Core Set for Stroke. The frequencies of linked interventions and the health discipline providing the intervention were calculated. Analysis revealed that 98.8% of interventions provided by the rehabilitation team could be linked to the Extended International Classification of Functioning, Disability and Health Core Set for Stroke, with more interventions for body function and structure than for activities and participation; no interventions for emotional concerns; and limited interventions for community, social and civic life. Results support previous recommendations for additions to the EICSS. The results support the use of the Extended International Classification of Functioning, Disability and Health Core Set for Stroke in New Zealand and demonstrates its use as a quality assurance tool that can evaluate the scope and practice of a rehabilitation service. Implications for Rehabilitation The Extended International Classification of Functioning Disability and Health Core Set for Stroke appears to represent the stroke interventions of a community stroke rehabilitation team in New Zealand. As a result, researchers and clinicians may have

  15. Correlation consistent basis sets for molecular core-valence effects with explicitly correlated wave functions: The atoms B-Ne and Al-Ar

    Science.gov (United States)

    Hill, J. Grant; Mazumder, Shivnath; Peterson, Kirk A.

    2010-02-01

    Correlation consistent basis sets have been optimized for accurately describing core-core and core-valence correlation effects with explicitly correlated F12 methods. The new sets, denoted cc-pCVnZ-F12 (n =D, T, Q) and aug-cc-pCF12VnZ (n =D, T, Q, 5), were developed by augmenting the cc-pVnZ-F12 and aug-cc-pVnZ families of basis sets with additional functions whose exponents were optimized based on the difference between all-electron and valence-electron correlation energies. The number of augmented functions added is fewer, in general, than in the standard cc-pCVnZ and cc-pwCVnZ families of basis sets. Optimal values of the geminal Slater exponent for use with these basis sets in MP2-F12 calculations are presented and are also recommended for CCSD-F12b calculations. Auxiliary basis sets for use in the resolution of the identity approximation in explicitly correlated calculations have also been optimized and matched to the new cc-pCVnZ-F12 series of orbital basis sets. The cc-pCVnZ-F12 basis sets, along with the new auxiliary sets, were benchmarked in CCSD(T)-F12b calculations of spectroscopic properties on a series of homo- and heteronuclear first and second row diatomic molecules. Comparing the effects of correlating the outer core electrons in these molecules with those from conventional CCSD(T) at the complete basis set limit, which involved calculations with new cc-pCV6Z basis sets for the second row elements that were also developed in the course of this work, it is observed that the F12 values are reasonably well converged already at just the triple-ζ level.

  16. The effect of various base/core materials on the setting of a polyvinyl siloxane impression material.

    Science.gov (United States)

    Moon, M G; Jarrett, T A; Morlen, R A; Fallo, G J

    1996-12-01

    Five resin-modified glass ionomers and amalgam, used as a base or core buildup material, were clinically evaluated for whether they effected polymerization of a low viscosity (light body) regular set polyvinyl siloxane impression material. A total of 20 samples per group was prepared according to the manufacturer's recommendations. Ten samples from each group were handled with latex gloves during mixing and the other 10 were handled with vinyl gloves. Five of the 10 samples had the outer surface prepared with a round diamond wheel. Impressions were made of all the samples. The impression materials were visually scored inhibited or noninhibited. Inhibited impression materials met at least one following criterion: (1) an oily substance on the surface of the impression readily collected on a sterile explorer tine as it was moved across the impression surface; (2) a rippled appearance on the surface of the impression material; or (3) unpolymerized impression material adherent to the prepared sample surface. If none of the criteria were observed, the impression was scored noninhibited. The data were analyzed with the chi square analysis (level of significance p = 0.05). Total chi square analysis revealed a significant difference between brands (p = 0.0001) and between prepared and non-prepared samples (p = 0.001). Interrater reliability data were analyzed with the kappa correlation analysis. Raters were in complete agreement (kappa = +1). The prepared samples of Vitrebond material had an inhibitory effect on the polymerization of Express impression material.

  17. Progress Towards a Core Set of Outcome Measures in Small-vessel Vasculitis. Report from OMERACT 9

    Science.gov (United States)

    MERKEL, PETER A.; HERLYN, KAREN; MAHR, ALFRED D.; NEOGI, TUHINA; SEO, PHILIP; WALSH, MICHAEL; BOERS, MAARTEN; LUQMANI, RAASHID

    2011-01-01

    The past decade has seen a substantial increase in the number and quality of clinical trials of new therapies for vasculitis, including randomized, controlled, multicenter trials that have successfully incorporated measures of disease activity and toxicity. However, because current treatment regimens for severe disease effectively induce initial remission and reduce mortality, future trials will focus on any of several goals including: (a) treatment of mild—moderate disease; (b) prevention of chronic damage; (c) reduction in treatment toxicity; or (d) more subtle differences in remission induction or maintenance. Thus, new trials will require outcome measure instruments that are more precise and are better able to detect effective treatments for different disease states and measure chronic manifestations of disease. The OMERACT Vasculitis Working Group comprises international clinical investigators with expertise in vasculitis who, since 2002, have worked collaboratively to advance the refinement of outcome measures in vasculitis, create new measures to address domains of illness not covered by current research approaches, and harmonize outcome assessment in vasculitis. The focus of the OMERACT group to date has been on outcome measures in small-vessel vasculitis with an overall goal of creating a core set of outcome measures for vasculitis, each of which fulfills the OMERACT filter of truth, discrimination, feasibility, and identifying additional domains requiring further research. This process has been informed by several ongoing projects providing data on outcomes of disease activity, disease-related damage, multidimensional health-related quality of life, and patient-reported ratings of the burden of vasculitis. PMID:19820226

  18. Application study of the components Activity and Participation of the ICF Checklist used in people with Multiple Sclerosis and its relation to the Core Sets

    Directory of Open Access Journals (Sweden)

    Rosé Colom Toldrá

    2016-10-01

    Full Text Available Introduction: The Core Set is a group of typical and significant functionality categories of the International Classification of Functioning, Disability and Health – ICF used for certain health conditions. Objective: The study reviewed the application of the component categories Activities and Participation based on the ICF Checklist for multiple sclerosis (MS and its relationship with the comprehensive and validated Core Sets by occupational therapists. Method: Descriptive quantitative research from collection and organization of data questionnaire based on the components Activities and Participation of the ICF Checklist - Version 2.1ª. Clinical form for the ICF containing 25 categories belonging to 6 domains and analysis of its relationship with the Core Sets. Participated 115 people with relapsing-remitting MS without disability to moderate disability, treated at the Central Institute of Hospital Clinics of the Faculty of Medicine University of São Paulo. We created database in Excel and made descriptive analysis of frequencies. Results: Most participants were women (85, mean age 32 years and 1 month (± 7.4. Study broadens the evidence of the applicability of the Comprehensive Core Set with 88% (22 and Core Set validated by occupational therapists with 72% (18 compared evaluated categories. More significant difficulties were encountered in the categories d640 Doing housework, d430 Lifting and carrying objects and d850 Remunerative employment, which reflected on the performance of various activities and social participation. Conclusion: Studies on application of the Core Set validated by occupational therapists are recommended to extend the evidence of professional clinical practice and inclusion of categories depending on the context.

  19. Proposal for a candidate core-set of fitness and strength tests for patients with childhood or adult idiopathic inflammatory myopathies

    Science.gov (United States)

    van der Stap, Djamilla K.D.; Rider, Lisa G.; Alexanderson, Helene; Huber, Adam M.; Gualano, Bruno; Gordon, Patrick; van der Net, Janjaap; Mathiesen, Pernille; Johnson, Liam G.; Ernste, Floranne C.; Feldman, Brian M.; Houghton, Kristin M.; Singh-Grewal, Davinder; Kutzbach, Abraham Garcia; Munters, Li Alemo; Takken, Tim

    2015-01-01

    OBJECTIVES Currently there are no evidence-based recommendations regarding which fitness and strength tests to use for patients with childhood or adult idiopathic inflammatory myopathies (IIM). This hinders clinicians and researchers in choosing the appropriate fitness- or muscle strength-related outcome measures for these patients. Through a Delphi survey, we aimed to identify a candidate core-set of fitness and strength tests for children and adults with IIM. METHODS Fifteen experts participated in a Delphi survey that consisted of five stages to achieve a consensus. Using an extensive search of published literature and through the expertise of the experts, a candidate core-set based on expert opinion and clinimetric properties was developed. Members of the International Myositis Assessment and Clinical Studies Group (IMACS) were invited to review this candidate core-set during the final stage, which led to a final candidate core-set. RESULTS A core-set of fitness- and strength-related outcome measures was identified for children and adults with IIM. For both children and adults, different tests were identified and selected for maximal aerobic fitness, submaximal aerobic fitness, anaerobic fitness, muscle strength tests and muscle function tests. CONCLUSIONS The core-set of fitness and strength-related outcome measures provided by this expert consensus process will assist practitioners and researchers in deciding which tests to use in IIM patients. This will improve the uniformity of fitness and strength tests across studies, thereby facilitating the comparison of study results and therapeutic exercise program outcomes among patients with IIM. PMID:26568594

  20. Updating the Psoriatic Arthritis (PsA) Core Domain Set: A Report from the PsA Workshop at OMERACT 2016.

    Science.gov (United States)

    Orbai, Ana-Maria; de Wit, Maarten; Mease, Philip J; Callis Duffin, Kristina; Elmamoun, Musaab; Tillett, William; Campbell, Willemina; FitzGerald, Oliver; Gladman, Dafna D; Goel, Niti; Gossec, Laure; Hoejgaard, Pil; Leung, Ying Ying; Lindsay, Chris; Strand, Vibeke; van der Heijde, Désirée M; Shea, Bev; Christensen, Robin; Coates, Laura; Eder, Lihi; McHugh, Neil; Kalyoncu, Umut; Steinkoenig, Ingrid; Ogdie, Alexis

    2017-10-01

    To include the patient perspective in accordance with the Outcome Measures in Rheumatology (OMERACT) Filter 2.0 in the updated Psoriatic Arthritis (PsA) Core Domain Set for randomized controlled trials (RCT) and longitudinal observational studies (LOS). At OMERACT 2016, research conducted to update the PsA Core Domain Set was presented and discussed in breakout groups. The updated PsA Core Domain Set was voted on and endorsed by OMERACT participants. We conducted a systematic literature review of domains measured in PsA RCT and LOS, and identified 24 domains. We conducted 24 focus groups with 130 patients from 7 countries representing 5 continents to identify patient domains. We achieved consensus through 2 rounds of separate surveys with 50 patients and 75 physicians, and a nominal group technique meeting with 12 patients and 12 physicians. We conducted a workshop and breakout groups at OMERACT 2016 in which findings were presented and discussed. The updated PsA Core Domain Set endorsed with 90% agreement by OMERACT 2016 participants included musculoskeletal disease activity, skin disease activity, fatigue, pain, patient's global assessment, physical function, health-related quality of life, and systemic inflammation, which were recommended for all RCT and LOS. These were important, but not required in all RCT and LOS: economic cost, emotional well-being, participation, and structural damage. Independence, sleep, stiffness, and treatment burden were on the research agenda. The updated PsA Core Domain Set was endorsed at OMERACT 2016. Next steps for the PsA working group include evaluation of PsA outcome measures and development of a PsA Core Outcome Measurement Set.

  1. Preliminary Test of a small heat pipe for hybrid control rod in-core passive decay heat removal system

    Energy Technology Data Exchange (ETDEWEB)

    Kim, In Guk; Ban, In Cheol [Ulsan National Institute of Science and Technology, Ulsan (Korea, Republic of)

    2014-05-15

    This paper introduces 'Hybrid control rod' combining its original function and heat removal ability. The high temperature operation and high resistance of radiation should be considered to adopt the hybrid heat pipe at the in-core condition. Other design consideration is to make extra inlet parts because it has a high risk of inlet boundary failure. It means that the introduction of heat pipe system is difficult to present nuclear power plants. The other concepts are presented to out-core cooling design but it has low performance compared with in-core heat removal system. Hybrid heat pipe for in-core heat removal system suggests the solution of these problems. Ultimate objective of this research is to develop the passive emergency decay heat removal system using hybrid heat pipes targeting design bases accidents such as station black-out (SBO) and small break loss of coolant accident (SBLOCA). The purpose of this work is to confirm the performance and heat transfer behavior of hybrid heat pipe. The hybrid heat pipe has special condition for operation. Therefore, it is hard to analyze their behavior in core. Table I shows the characteristics of hybrid heat pipe and consideration for manufacturing the heat pipe.

  2. The International Classification of Functioning, Disability and Health (ICF) Core Sets: application to a postmenopausal woman with rheumatoid arthritis and osteoporosis of the spine.

    Science.gov (United States)

    Lorbergs, Amanda L; MacIntyre, Norma J

    2013-10-01

    The International Classification of Functioning, Disability and Health (ICF) framework facilitates systematic assessment of functioning across four components. ICF Core Sets are proposed to be beneficial for clinicians in multidisciplinary care settings because they provide a common language for communication. A clinical vignette of a postmenopausal woman with rheumatoid arthritis (RA) and a non-traumatic vertebral fracture is presented to discuss how the ICF Core Sets for RA and osteoporosis (OP) can be helpful in structuring clinical decisions. To demonstrate how condition-specific ICF Core Sets can be used to evaluate and treat women with two comorbidities, each component of the ICF Core Sets is compared across conditions and integrated into clinical decision-making. Topics covered include: exercise tolerance, urinary continence, bone mass, fear of falling, and environmental factors. The benefits of thorough communication with the client and a common language across healthcare disciplines are highlighted as the potential benefits of the ICF framework; however, limitations to uptake of the ICF in clinical practice are also addressed.

  3. A preliminary investigation into the use of Red Pine (Pinus Resinosa) tree cores as historic passive samplers of POPs in outdoor air

    Science.gov (United States)

    Rauert, Cassandra; Harner, Tom

    2016-09-01

    The suitability of Red Pine trees (Pinus Resinosa) to act as passive samplers for persistent organic pollutants (POPs) in outdoor air and to provide historic information on air concentration trends was demonstrated in this preliminary investigation. Red Pine tree cores from Toronto, Canada, were tested for polycyclic aromatic hydrocarbon (PAHs), alkylated-PAHs, nitro and oxy-PAHs, polybrominated diphenyl ethers (PBDEs) and novel brominated flame retardants (novel BFRs). The PBDEs and novel BFRs demonstrated a similar relative contribution in cores representing 30 years of tree growth, to that reported in contemporary air samples. Analysis of tree ring segments of 5-15 years resulted in detectable concentrations of some PAHs and alk-PAHs and demonstrated a transition from petrogenic sources to pyrogenic sources over the period 1960-2015. A simple uptake model was developed that treats the tree rings as linear-phase passive air samplers. The bark infiltration factor, IFBARK, is a key parameter of the model that reflects the permeability of the bark to allow chemicals to be transferred from ambient air to the outer tree layer (cambium). An IFBARK of about 2% was derived for the Red Pine trees based on tree core and air monitoring data.

  4. Chinese Athletes' Core Values: Preliminary Construction%我国运动员核心价值观的初步建构

    Institute of Scientific and Technical Information of China (English)

    马雪

    2012-01-01

    运用文献资料法、专家评价法、数理统计法等对我国运动员核心价值观核心词汇进行收集分类、并制定专家评价表,请国内知名心理学、体育学界专家进行评价,初步构建出了我国运动员核心价值观:为国争光、科学训练、拼搏超越、团结协作、公平竞争、勇于创新,并阐明其科学内涵。%Based on literature, expert evaluation, mathematical statistics, Chinese athletes' core values core vocabulary were collected, expert evaluation sheet was drawn up, well-known psychology, sports experts did the evaluation, preliminary constructed Chinese athletes' core values: Win honor for the country (motherland) , scientific training, overcome and surpass, solidarity and coordination, fair competition, active in innovation, and expound on its scientific content.

  5. Preliminary Physical Stratigraphy and Geophysical Data of the USGS Hope Plantation Core (BE-110), Bertie County, North Carolina

    Science.gov (United States)

    Weems, Robert E.; Seefelt, Ellen L.; Wrege, Beth M.; Self-Trail, Jean M.; Prowell, David C.; Durand, Colleen; Cobbs, Eugene F.; McKinney, Kevin C.

    2007-01-01

    Introduction In March and April, 2004, the U.S. Geological Survey (USGS), in cooperation with the North Carolina Geological Survey (NCGS) and the Raleigh Water Resources Discipline (WRD), drilled a stratigraphic test hole and well in Bertie County, North Carolina (fig. 1). The Hope Plantation test hole (BE-110-2004) was cored on the property of Hope Plantation near Windsor, North Carolina. The drill site is located on the Republican 7.5 minute quadradrangle at lat 36?01'58'N., long 78?01'09'W. (decimal degrees 36.0329 and 77.0192) (fig. 2). The altitude of the site is 48 ft above mean sea level as determined by Paulin Precise altimeter. This test hole was continuously cored by Eugene F. Cobbs, III and Kevin C. McKinney (USGS) to a total depth of 1094.5 ft. Later, a ground water observation well was installed with a screened interval between 315-329 feet below land surface (fig. 3). Upper Triassic, Lower Cretaceous, Upper Cretaceous, Tertiary, and Quaternary sediments were recovered from the site. The core is stored at the NCGS Coastal Plain core storage facility in Raleigh, North Carolina. In this report, we provide the initial lithostratigraphic summary recorded at the drill site along with site core photographs, data from the geophysical logger, calcareous nannofossil biostratigraphic correlations (Table 1) and initial hydrogeologic interpretations. The lithostratigraphy from this core can be compared to previous investigations of the Elizabethtown corehole, near Elizabethtown, North Carolina in Bladen County (Self-Trail, Wrege, and others, 2004), the Kure Beach corehole, near Wilmington, North Carolina in New Hanover County (Self-Trail, Prowell, and Christopher, 2004), the Esso #1, Esso #2, Mobil #1 and Mobil #2 cores in the Albermarle and Pamlico Sounds (Zarra, 1989), and the Cape Fear River outcrops in Bladen County (Farrell, 1998; Farrell and others, 2001). This core is the third in a series of planned benchmark coreholes that will be used to elucidate the

  6. Exploring the comparative responsiveness of a core set of outcome measures in a school-based conductive education programme.

    Science.gov (United States)

    Wright, F V; Boschen, K; Jutai, J

    2005-05-01

    Conductive education (CE) is a holistic educational system that uses an active cognitive approach to teach individuals with motor disorders to become more functional participants in daily activities. While CE's popularity continues to grow in North America and Europe, its effectiveness has not been established. The lack of definition of responsive outcome measures for evaluation of CE programmes has limited the interpretability of conclusions from earlier studies evaluating effectiveness. To determine which measures from a core set were most responsive to physical, functional and psychosocial changes associated with a school-based CE programme. This was a one-group before and after data collection design using an 8-month follow-up period. We enrolled a referral sample of nine children with cerebral palsy in Kindergarten or Grade 1 (Gross Motor Function Classification System levels 3, 4 or 5). The study took place within a school-based CE programme at a Canadian children's rehabilitation centre. Children participated in a CE full-day class for an entire school year. Physical, functional, psychosocial and participation measures included: Gross Motor Function Measure (GMFM), Quality of Upper Extremity Skills Test (QUEST), Peabody Developmental Motor Scales, Paediatric Evaluation of Disability Inventory (PEDI), Pictorial Scale of Perceived Competence and Social Acceptance for Young Children, Individualized Educational Plan, and Goal Attainment Scaling (GAS). Four children from the study's second year were also evaluated on the Impact on Family Scale (IFS), GAS and School Function Assessment. The Gross Motor Function Measure, QUEST, PEDI (Caregiver Assistance) and IFS were most responsive to change. GAS was useful in documenting and quantifying goals. Problems were encountered in evaluating self-esteem and school participation. Several strong measures of outcome were identified. Further work is needed to find valid and sensitive psychosocial and school participation

  7. Recommendations for a core outcome set for measuring standing balance in adult populations: a consensus-based approach.

    Directory of Open Access Journals (Sweden)

    Kathryn M Sibley

    Full Text Available Standing balance is imperative for mobility and avoiding falls. Use of an excessive number of standing balance measures has limited the synthesis of balance intervention data and hampered consistent clinical practice.To develop recommendations for a core outcome set (COS of standing balance measures for research and practice among adults.A combination of scoping reviews, literature appraisal, anonymous voting and face-to-face meetings with fourteen invited experts from a range of disciplines with international recognition in balance measurement and falls prevention. Consensus was sought over three rounds using pre-established criteria.The scoping review identified 56 existing standing balance measures validated in adult populations with evidence of use in the past five years, and these were considered for inclusion in the COS.Fifteen measures were excluded after the first round of scoring and a further 36 after round two. Five measures were considered in round three. Two measures reached consensus for recommendation, and the expert panel recommended that at a minimum, either the Berg Balance Scale or Mini Balance Evaluation Systems Test be used when measuring standing balance in adult populations.Inclusion of two measures in the COS may increase the feasibility of potential uptake, but poses challenges for data synthesis. Adoption of the standing balance COS does not constitute a comprehensive balance assessment for any population, and users should include additional validated measures as appropriate.The absence of a gold standard for measuring standing balance has contributed to the proliferation of outcome measures. These recommendations represent an important first step towards greater standardization in the assessment and measurement of this critical skill and will inform clinical research and practice internationally.

  8. Current Status of the Transmutation Reactor Technology and Preliminary Evaluation of Transmutation Performance of the KALIMER Core

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Ser Gi; Sim, Yoon Sub; Kim, Yeong Il; Kim, Young Gyum; Lee, Byung Woon; Song, Hoon; Lee, Ki Bog; Jang, Jin Wook; Lee, Dong Uk

    2005-08-15

    Recently the most countries using the nuclear power plants for electricity generation have been faced with the problem of the preparation of the repository for the disposition of the nuclear waste generated from LWR. It was well-known that the issues related with long term risk of the radioactive wastes for the future generations are due only to 1% of the total waste. This small fraction of 1% consists of transuranic (TRU) nuclides such as Pu, Np, Am, Cm and the long lived fission products such as Tc and I. For the transuranic (TRU) nuclides, their half lives range from several years to several hundred thousands years and hence their radioactive toxicity can be lasted over very long time period. This has made the change of the rule of the fast spectrum reactor from the economical use of uranium resource through breeding to the reduction of the nuclear waste through the transmutation. The purpose of this study is to obtain the basic knowledge on the nuclear transmutation technology and to suggest the technical solution ways for the future technology development and enhancement through a survey of the state-of-art of the international research on the nuclear transmutation. The increase of the transmutation rate requires the reduction of the breeding ratio. In fact, the transmutation rate is determined by the breeding ratio. The reduction of the breeding ratio can be achieved by reducing the U-238 content in fuel or increasing the neutron leakage through core boundary or absorbing the neutrons by using some absorbers. However, the reduction of the U-238 content results in the degradation of the fuel Doppler coefficient that is one of the most important safety-related parameters and the reduction of the effective delayed neutron fraction that is related with the controllability of the reactor core. Also, the increase of the transmutation rate can lead to the increase of the coolant void reactivity worth unless some ways to reduce the coolant void reactivity are not

  9. Identification of a Core Set of Exercise Tests for Children and Adolescents with Cerebral Palsy: A Delphi Survey of Researchers and Clinicians

    Science.gov (United States)

    Verschuren, Olaf; Ketelaar, Marjolijn; Keefer, Daniel; Wright, Virginia; Butler, Jane; Ada, Louise; Maher, Carol; Reid, Siobhan; Wright, Marilyn; Dalziel, Blythe; Wiart, Lesley; Fowler, Eileen; Unnithan, Viswanath; Maltais, Desiree B.; van den Berg-Emons, Rita; Takken, Tim

    2011-01-01

    Aim: Evidence-based recommendations regarding which exercise tests to use in children and adolescents with cerebral palsy (CP) are lacking. This makes it very difficult for therapists and researchers to choose the appropriate exercise-related outcome measures for this group. This study aimed to identify a core set of exercise tests for children…

  10. How well are the ASAS/OMERACT Core Outcome Sets for Ankylosing Spondylitis implemented in randomized clinical trials? A systematic literature review.

    Science.gov (United States)

    Bautista-Molano, Wilson; Navarro-Compán, Victoria; Landewé, Robert B M; Boers, Maarten; Kirkham, Jamie J; van der Heijde, Désirée

    2014-09-01

    This study aims to investigate how well the Assessment of SpondyloArthritis international Society (ASAS)/Outcome Measures in Rheumatology Clinical Trials (OMERACT) core set and response criteria for ankylosing spondylitis (AS) have been implemented in randomized controlled trials (RCTs) testing pharmacological and non-pharmacological interventions. A systematic literature search was performed up to June 2013 looking for RCTs in patients with axial spondyloarthritis (SpA) (AS and non-radiographic axial SpA). The assessed domains and instruments belonging to the core sets for disease-controlling anti-rheumatic therapy (DC-ART) and symptom-modifying anti-rheumatic drugs (SMARDs) were extracted. Results were reported separately for those trials published until 2 years after the publication of the core set (1 April 2001; 'control trials') and those trials published at least 2 years after the publication date ('implementation trials'). One hundred twenty-three articles from 99 RCTs were included in the analysis, comparing 48 'control trials' and 51 'implementation trials'. Regarding DC-ART core set, the following domains were significantly more frequently assessed in the 'implementation group' in comparison to the 'control group': 'physical function' (100 vs 41.7 %; p ≤ 0.001), 'peripheral joints/entheses' (100 vs 33.3 %; p ≤ 0.001) and 'fatigue' (100 vs 0 %; p ≤ 0.001). Three instruments were significantly more used in the 'implementation group': Bath Ankylosing Spondylitis Functional Index (BASFI) (100 vs 8.3 %; p = ≤ 0.001), CRP (92.3 vs 58.3 %; p = 0.01) and Bath Ankylosing Spondylitis Metrology Index (BASMI) (53.8 vs 0 %; p = 0.001). Regarding SMARD core set domains, physical function (92 vs 23 %; p ≤ 0.001) and fatigue (84 vs 17 %; p ≤ 0.001), as well as the instruments BASFI (88 vs 14 %; p ≤ 0.001) and BASMI (52 vs 0 %; p ≤ 0.001), increased significantly in the 'implementation group'. Twenty per cent of

  11. Identification of candidate categories of the International Classification of Functioning Disability and Health (ICF for a Generic ICF Core Set based on regression modelling

    Directory of Open Access Journals (Sweden)

    Üstün Bedirhan T

    2006-07-01

    Full Text Available Abstract Background The International Classification of Functioning, Disability and Health (ICF is the framework developed by WHO to describe functioning and disability at both the individual and population levels. While condition-specific ICF Core Sets are useful, a Generic ICF Core Set is needed to describe and compare problems in functioning across health conditions. Methods The aims of the multi-centre, cross-sectional study presented here were: a to propose a method to select ICF categories when a large amount of ICF-based data have to be handled, and b to identify candidate ICF categories for a Generic ICF Core Set by examining their explanatory power in relation to item one of the SF-36. The data were collected from 1039 patients using the ICF checklist, the SF-36 and a Comorbidity Questionnaire. ICF categories to be entered in an initial regression model were selected following systematic steps in accordance with the ICF structure. Based on an initial regression model, additional models were designed by systematically substituting the ICF categories included in it with ICF categories with which they were highly correlated. Results Fourteen different regression models were performed. The variance the performed models account for ranged from 22.27% to 24.0%. The ICF category that explained the highest amount of variance in all the models was sensation of pain. In total, thirteen candidate ICF categories for a Generic ICF Core Set were proposed. Conclusion The selection strategy based on the ICF structure and the examination of the best possible alternative models does not provide a final answer about which ICF categories must be considered, but leads to a selection of suitable candidates which needs further consideration and comparison with the results of other selection strategies in developing a Generic ICF Core Set.

  12. 77 FR 286 - Medicaid Program: Initial Core Set of Health Care Quality Measures for Medicaid-Eligible Adults

    Science.gov (United States)

    2012-01-04

    ... numerator, denominator, exclusions, prevalence, clinical guidelines, past performance rates, etc.) on each...-up. Published clinical guidelines relevant to the measure. Validity and reliability of results... criteria against which to evaluate the proposed core measures: importance; scientific evidence...

  13. Scaling up Kernel Grower Clustering Method for Large Data Sets via Core-sets%基于核集合的大数据快速Kernel Grower聚类方法

    Institute of Scientific and Technical Information of China (English)

    常亮; 邓小明; 郑碎武; 王永庆

    2008-01-01

    Kernel grower is a novel kernel clustering method proposed recently by Camastra and Verri. It shows good performance for various data sets and compares favorably with respect to popular clustering algorithms. However, the main drawback of the method is the weak scaling ability in dealing with large data sets, which restricts its application greatly. In this paper, we propose a scaled-up kernel grower method using core-sets, which is significantly faster than the original method for large data clustering.Meanwhile, it can deal with very large data sets. Numerical experiments on benchmark data sets as well as synthetic data sets show the efficiency of the proposed method. The method is also applied to real image segmentation to illustrate its performance.

  14. International Classification of Functioning, Disability and Health: development of an assessment set to evaluate functioning based on the Brief ICF Core Set for Hand Conditions - ICF HandA.

    Science.gov (United States)

    Kus, S; Dereskewitz, C; Coenen, M; Rauch, A; Rudolf, K-D

    2017-09-01

    Timely identification of patients' problems after disorder or injury of the hand requires a thorough functional assessment. However, the variety of outcome measures available makes it difficult to choose the appropriate instrument. The brief International Classification of Functioning, Disability and Health (Brief ICF Core Set for Hand Conditions) provides a standard for what aspects need to be measured in hand injuries and disorders without specifying how to make the assessment. We developed the ICF-based Assessment Hand (ICF HandA), an assessment set for functioning based on the Brief ICF Core Set for Hand Conditions. First, we performed a literature review and an expert survey to pool outcome measures appropriate to assess functioning in clinical practice. At an interdisciplinary consensus conference experts decided on the outcome measures to be included in the ICF HandA. The ICF HandA provides a consensus on outcome measures and instruments to systematically assess function in patients with hand injuries and disorders.

  15. Correlation consistent valence basis sets for use with the Stuttgart-Dresden-Bonn relativistic effective core potentials the atoms Ga-Kr and In-Xe

    CERN Document Server

    Martin, J M L; Martin, Jan M.L.; Sundermann, Andreas

    2001-01-01

    We propose large-core correlation-consistent pseudopotential basis sets for the heavy p-block elements Ga-Kr and In-Xe. The basis sets are of cc-pVTZ and cc-pVQZ quality, and have been optimized for use with the large-core (valence-electrons only) Stuttgart-Dresden-Bonn relativistic pseudopotentials. Validation calculations on a variety of third-row and fourth-row diatomics suggest them to be comparable in quality to the all-electron cc-pVTZ and cc-pVQZ basis sets for lighter elements. Especially the SDB-cc-pVQZ basis set in conjunction with a core polarization potential (CPP) yields excellent agreement with experiment for compounds of the later heavy p-block elements. For accurate calculations on Ga (and, to a lesser extent, Ge) compounds, explicit treatment of 13 valence electrons appears to be desirable, while it seems inevitable for In compounds. For Ga and Ge, we propose correlation consistent basis sets extended for (3d) correlation. For accurate calculations on organometallic complexes of interest to h...

  16. Preliminary physical stratigraphy, biostratigraphy, and geophysical data of the USGS South Dover Bridge Core, Talbot County, Maryland

    Science.gov (United States)

    Alemán González, Wilma B.; Powars, David S.; Seefelt, Ellen L.; Edwards, Lucy E.; Self-Trail, Jean M.; Durand, Colleen T.; Schultz, Arthur P.; McLaughlin, Peter P.

    2012-01-01

    The South Dover Bridge (SDB) corehole was drilled in October 2007 in Talbot County, Maryland. The main purpose for drilling this corehole was to characterize the Upper Cretaceous and Paleogene lithostratigraphy and biostratigraphy of the aquifers and confining units of this region. The data obtained from this core also will be used as a guide to geologic mapping and to help interpret well data from the eastern part of the Washington East 1:100,000-scale map near the town of Easton, Md. Core drilling was conducted to a depth of 700 feet (ft). The Cretaceous section was not penetrated due to technical problems during drilling. This project was funded by the U.S. Geological Survey’s (USGS) Eastern Geology and Paleoclimate Science Center (EGPSC) as part of the Geology of the Atlantic Watersheds Project; this project was carried out in cooperation with the Maryland Geological Survey (MGS) through partnerships with the Aquifer Characterization Program of the USGS’s Maryland-Delaware-District of Columbia Water Science Center and the National Cooperative Geologic Mapping Program. The SDB corehole was drilled by the USGS drilling crew in the northeastern corner of the Trappe 7.5-minute quadrangle, near the type locality of the Boston Cliffs member of the Choptank Formation. Geophysical logs (gamma ray, single point resistance, and 16-inch and 64-inch normal resistivity) were run to a depth of 527.5 ft; the total depth of 700.0 ft could not be reached because of the collapse of the lower part of the hole. Of the 700.0 ft drilled, 531.8 ft of core were recovered, representing a 76 percent core recovery. The elevation of the top of the corehole is approximately 12 ft above mean sea level; its coordinates are lat 38°44′49.34″N. and long 76°00′25.09″W. (38.74704N., 76.00697W. in decimal degrees). A groundwater monitoring well was not installed at this site. The South Dover Bridge corehole was the first corehole that will be used to better understand the geology and

  17. Computer code and users' guide for the preliminary analysis of dual-mode space nuclear fission solid core power and propulsion systems, NUROC3A. AMS report No. 1239b

    Energy Technology Data Exchange (ETDEWEB)

    Nichols, R.A.; Smith, W.W.

    1976-06-30

    The three-volume report describes a dual-mode nuclear space power and propulsion system concept that employs an advanced solid-core nuclear fission reactor coupled via heat pipes to one of several electric power conversion systems. The second volume describes the computer code and users' guide for the preliminary analysis of the system.

  18. Late Quaternary sediment deposition of core MA01 in the Mendeleev Ridge, the western Arctic Ocean: Preliminary results

    Science.gov (United States)

    Park, Kwang-Kyu; Kim, Sunghan; Khim, Boo-Keun; Xiao, Wenshen; Wang, Rujian

    2014-05-01

    Late Quaternary deep marine sediments in the Arctic Ocean are characterized by brown layers intercalated with yellowish to olive gray layers (Poore et al., 1999; Polyak et al., 2004). Previous studies reported that the brown and gray layers were deposited during interglacial (or interstadial) and glacial (or stadial) periods, respectively. A 5.5-m long gravity core MA01 was obtained from the Mendeleev Ridge in the western Arctic Ocean by R/V Xue Long during scientific cruise CHINARE-V. Age (~450 ka) of core MA01 was tentatively estimated by correlation of brown layers with an adjacent core HLY0503-8JPC (Adler et al., 2009). A total of 22 brown layers characterized by low L* and b*, high Mn concentration, and abundant foraminifera were identified. Corresponding gray layers are characterized by high L* and b*, low Mn concentration, and few foraminiferal tests. Foraminifera abundance peaks are not well correlated to CaCO3 peaks which occurred with the coarse-grained (>0.063 mm) fractions (i.e., IRD) both in brown and gray layers. IRDs are transported presumably by sea ice for the deposition of brown layers and by iceberg for the deposition of gray layers (Polyak et al., 2004). A strong correlation coefficient (r2=0.89) between TOC content and C/N ratio indicates that the major source of organic matter is terrestrial. The good correlations of CaCO3 content to TOC (r2=0.56) and C/N ratio (r2=0.69) imply that IRDs contain detrital CaCO3 which mainly originated from the Canadian Arctic Archipelago. In addition, high kaolinite/chlorite (K/C) ratios mostly correspond to CaCO3 peaks, which suggests that the fine-grained particles in the Mendeleev Ridge are transported from the north coast Alaska and Canada where Mesozoic and Cenozoic strata are widely distributed. Thus, the Beaufort Gyre, the predominant surface current in the western Arctic Ocean, played an important role in the sediment delivery to the Mendeleev Ridge. It is worthy of note that the TOC and CaCO3 peaks are

  19. Fluid inclusions and preliminary studies of hydrothermal alteration in core hole PLTG-1, Platanares geothermal area, Honduras

    Science.gov (United States)

    Bargar, K.E.

    1991-01-01

    The Platanares geothermal area in western Honduras consists of more than 100 hot springs that issue from numerous hot-spring groups along the banks or within the streambed of the Quebrada de Agua Caliente (brook of hot water). Evaluation of this geothermal area included drilling a 650-m deep PLTG-1 drill hole which penetrated a surface mantling of stream terrace deposits, about 550 m of Tertiary andesitic lava flows, and Cretaceous to lower Tertiary sedimentary rocks in the lower 90 m of the drill core. Fractures and cavities in the drill core are partly to completely filled by hydrothermal minerals that include quartz, kaolinite, mixed-layer illite-smectite, barite, fluorite, chlorite, calcite, laumontite, biotite, hematite, marcasite, pyrite, arsenopyrite, stibnite, and sphalerite; the most common open-space fillings are calcite and quartz. Biotite from 138.9-m depth, dated at 37.41 Ma by replicate 40Ar/39 Ar analyses using a continuous laser system, is the earliest hydrothermal mineral deposited in the PLTG-1 drill core. This mid-Tertiary age indicates that at least some of the hydrothermal alteration encountered in the PLTG-1 drill core occured in the distant past and is unrelated to the present geothermal system. Furthermore, homogenization temperatures (Th) and melting-point temperatures (Tm) for fluid inclusions in two of the later-formed hydrothermal minerals, calcite and barite, suggest that the temperatures and concentration of dissolved solids of the fluids present at the time these fluid inclusions formed were very different from the present temperatures and fluid chemistry measured in the drill hole. Liquid-rich secondary fluid inclusions in barite and caicite from drill hole PLTG-1 have Th values that range from about 20??C less than the present measured temperature curve at 590.1-m depth to as much as 90??C higher than the temperature curve at 46.75-m depth. Many of the barite Th measurements (ranging between 114?? and 265??C) plot above the

  20. An unadjusted 25 group neutron cross section set for fast reactor core calculations from JENDL-2 library

    Energy Technology Data Exchange (ETDEWEB)

    Devan, K.; Gopalakrishnan, V.; Lee, S.M. [Nuclear Data Section Indira Ganhi Centre for Atomic Research, Tamilnadu (India)

    1994-12-31

    We have created a 25 group neutron cross section set (IGCJENDL) for nuclides of interest to LMFBRs from the Japanese Evaluated Nuclear Data Library - Version 2 (JENDL-2) in the format of French adjusted Cadarache Version 2 set (1969). The integral validation of IGCJENDL set was done by analyzing nine fast critical assemblies proposed by Cross Section Evaluation Working Group (CSEWG). The calculated integral parameters agreed reasonably well with the reported measured values. It is found that this set predicts the integral parameters, k-eff in particular, close to that predicted by adjusted CARNAVAL IV (French) or BNAB-78 (Russian) sets, for a 1200 MWe theoretical benchmark, representing a large power reactor.

  1. CORE_TF: a user-friendly interface to identify evolutionary conserved transcription factor binding sites in sets of co-regulated genes

    Science.gov (United States)

    Hestand, Matthew S; van Galen, Michiel; Villerius, Michel P; van Ommen, Gert-Jan B; den Dunnen, Johan T; 't Hoen, Peter AC

    2008-01-01

    Background The identification of transcription factor binding sites is difficult since they are only a small number of nucleotides in size, resulting in large numbers of false positives and false negatives in current approaches. Computational methods to reduce false positives are to look for over-representation of transcription factor binding sites in a set of similarly regulated promoters or to look for conservation in orthologous promoter alignments. Results We have developed a novel tool, "CORE_TF" (Conserved and Over-REpresented Transcription Factor binding sites) that identifies common transcription factor binding sites in promoters of co-regulated genes. To improve upon existing binding site predictions, the tool searches for position weight matrices from the TRANSFACR database that are over-represented in an experimental set compared to a random set of promoters and identifies cross-species conservation of the predicted transcription factor binding sites. The algorithm has been evaluated with expression and chromatin-immunoprecipitation on microarray data. We also implement and demonstrate the importance of matching the random set of promoters to the experimental promoters by GC content, which is a unique feature of our tool. Conclusion The program CORE_TF is accessible in a user friendly web interface at . It provides a table of over-represented transcription factor binding sites in the users input genes' promoters and a graphical view of evolutionary conserved transcription factor binding sites. In our test data sets it successfully predicts target transcription factors and their binding sites. PMID:19036135

  2. Accuracy of geometries : influence of basis set, exchange-correlation potential, inclusion of core electrons, and relativistic corrections

    NARCIS (Netherlands)

    Swart, M; Snijders, JG

    The geometries of a set of small molecules were optimized using eight different exchange-correlation (xc) potentials in a few different basis sets of Slater-type orbitals, ranging from a minimal basis (I) to a triple-zeta valence basis plus double polarization functions (VII). This enables a

  3. CORE_TF: a user-friendly interface to identify evolutionary conserved transcription factor binding sites in sets of co-regulated genes

    Directory of Open Access Journals (Sweden)

    den Dunnen Johan T

    2008-11-01

    Full Text Available Abstract Background The identification of transcription factor binding sites is difficult since they are only a small number of nucleotides in size, resulting in large numbers of false positives and false negatives in current approaches. Computational methods to reduce false positives are to look for over-representation of transcription factor binding sites in a set of similarly regulated promoters or to look for conservation in orthologous promoter alignments. Results We have developed a novel tool, "CORE_TF" (Conserved and Over-REpresented Transcription Factor binding sites that identifies common transcription factor binding sites in promoters of co-regulated genes. To improve upon existing binding site predictions, the tool searches for position weight matrices from the TRANSFACR database that are over-represented in an experimental set compared to a random set of promoters and identifies cross-species conservation of the predicted transcription factor binding sites. The algorithm has been evaluated with expression and chromatin-immunoprecipitation on microarray data. We also implement and demonstrate the importance of matching the random set of promoters to the experimental promoters by GC content, which is a unique feature of our tool. Conclusion The program CORE_TF is accessible in a user friendly web interface at http://www.LGTC.nl/CORE_TF. It provides a table of over-represented transcription factor binding sites in the users input genes' promoters and a graphical view of evolutionary conserved transcription factor binding sites. In our test data sets it successfully predicts target transcription factors and their binding sites.

  4. Content of RNA originating from thyroid in washouts from fine-needle and core-needle aspiration biopsy - preliminary study.

    Science.gov (United States)

    Woliński, Kosma; Stangierski, Adam; Szczepanek-Parulska, Ewelina; Gurgul, Edyta; Wrotkowska, Elżbieta; Biczysko, Maciej; Ruchała, Marek

    2016-01-01

    In the evaluation of molecular markers in washouts from fine-needle aspiration biopsy (FNAB) the extremely small amount of material can be a major problem. Some authors tried to use washouts from core-needle aspiration biopsy (CNABs) to gain more material from larger needles. However, according to some studies, CNAB samples are commonly contaminated with blood. The aim of our study was to evaluate the proportion of nucleic acids from thyroid cells in washouts from FNAB and CNAB by measuring the relative expression of cytokeratin 17 (KRT17) on the mRNA level. Relative expression of KRT17 and GADPH (reference gene) in washouts from FNAB and CNAB was measured using real-time PCR technique and compared to the results from surgical specimens. Surgical specimens form 22 nodules, FNAB samples from 20 lesions and CNAB samples from 24 lesions were analysed. The median difference in cycle threshold (Ct) between FNAB samples and surgical specimens was 3.3 (p = 0.047). In CNAB samples KRT17 was undetectable in most cases (median incalculable; proportion of samples with undetectable KRT17 significantly higher than in FNAB samples). Samples obtained with different biopsy techniques had different proportions of contents. The proportionally low content of epithelial cells in CNAB can result in underestimated expression of molecular markers of malignancy. Consequently, the risk of malignancy or unfavourable prognosis can also be underestimated. To conclude, results obtained from samples gained with one biopsy technique cannot be directly related to thresholds, and generally with experiences gained with other techniques, because it can lead to incorrect clinical interpretation of the results. (Endokrynol Pol 2016; 67 (6): 550-553).

  5. Preliminary Results from the AIDP-2 and AIDP-3 Drill Cores Hint at Systematic Mo Enrichments in the ~2.65 Ga Roy Hill Shale

    Science.gov (United States)

    Roy, M.; Ostrander, C. M.; Lyons, T. W.; Olson, S. L.; Buick, R.; Anbar, A. D.

    2014-12-01

    In order to better understand the timing of the earliest oxygenation of Earth's surface environment, we are pursuing a multi-proxy investigation of paleoredox conditions in diamond drill cores through sedimentary rocks of the Archean Fortescue & Hamersley Groups. These cores were recovered in 2012 by the Agouron Institute from the Pilbara Craton of Western Australia. The AIDP-2 core samples a stratigraphic succession of carbonate and sulfidic, organic-rich shale in the Carawine Dolomite and Jeerinah Formation representing a shallow near-shore depositional setting. Core AIDP-3 samples a transition from BIF in the Marra Mamba Formation to organic-rich shales in the underlying Jeerinah Formation representing a deeper offshore depositional setting. We have analyzed 322 black shale samples from the Roy Hill Member of the Jeerinah Formation deposited just before the transition from the Fortescue to Hamersley Group. Roy Hill black shale units are mostly pyritic in AIDP-3, but are less so in AIDP-2. The Roy Hill Member of AIDP-3 extends from 2.629 Ga to2.676 Ga and contains the 2.632Ga Jeerinah impact layer, whereas the Roy Hill member of AIDP-2 is slightly older, lying beneath the Jeerinah impact layer, and has been dated to 2.636 Ga to >2.643 Ga [1]. Our initial findings reveal that Mo concentrations range between 0.7 and 7 ppm in the Roy Hill black shale member of AIDP-2 and AIDP-3. Corresponding Mo/Al ratios range between 1-9×10-5 ppm/ppm, indicating slight Mo enrichment relative to average continental crust. These results are consistent with a previous study by Scott et al. [2], which suggested little or no Mo enrichment. However, the higher resolution sampling in this study allows us to clearly resolve the Mo/Al depth profiles in these late Archean cores. These data suggest that the variations we see are not due to analytical scatter or sample variability, but instead represent real variations in Mo scavenged into these sediments. Ongoing work is focused on

  6. Hyper Text Mark-up Language and Dublin Core metadata element set usage in websites of Iranian State Universities’ libraries

    Science.gov (United States)

    Zare-Farashbandi, Firoozeh; Ramezan-Shirazi, Mahtab; Ashrafi-Rizi, Hasan; Nouri, Rasool

    2014-01-01

    Introduction: Recent progress in providing innovative solutions in the organization of electronic resources and research in this area shows a global trend in the use of new strategies such as metadata to facilitate description, place for, organization and retrieval of resources in the web environment. In this context, library metadata standards have a special place; therefore, the purpose of the present study has been a comparative study on the Central Libraries’ Websites of Iran State Universities for Hyper Text Mark-up Language (HTML) and Dublin Core metadata elements usage in 2011. Materials and Methods: The method of this study is applied-descriptive and data collection tool is the check lists created by the researchers. Statistical community includes 98 websites of the Iranian State Universities of the Ministry of Health and Medical Education and Ministry of Science, Research and Technology and method of sampling is the census. Information was collected through observation and direct visits to websites and data analysis was prepared by Microsoft Excel software, 2011. Results: The results of this study indicate that none of the websites use Dublin Core (DC) metadata and that only a few of them have used overlaps elements between HTML meta tags and Dublin Core (DC) elements. The percentage of overlaps of DC elements centralization in the Ministry of Health were 56% for both description and keywords and, in the Ministry of Science, were 45% for the keywords and 39% for the description. But, HTML meta tags have moderate presence in both Ministries, as the most-used elements were keywords and description (56%) and the least-used elements were date and formatter (0%). Conclusion: It was observed that the Ministry of Health and Ministry of Science follows the same path for using Dublin Core standard on their websites in the future. Because Central Library Websites are an example of scientific web pages, special attention in designing them can help the researchers

  7. Hyper Text Mark-up Language and Dublin Core metadata element set usage in websites of Iranian State Universities' libraries.

    Science.gov (United States)

    Zare-Farashbandi, Firoozeh; Ramezan-Shirazi, Mahtab; Ashrafi-Rizi, Hasan; Nouri, Rasool

    2014-01-01

    Recent progress in providing innovative solutions in the organization of electronic resources and research in this area shows a global trend in the use of new strategies such as metadata to facilitate description, place for, organization and retrieval of resources in the web environment. In this context, library metadata standards have a special place; therefore, the purpose of the present study has been a comparative study on the Central Libraries' Websites of Iran State Universities for Hyper Text Mark-up Language (HTML) and Dublin Core metadata elements usage in 2011. The method of this study is applied-descriptive and data collection tool is the check lists created by the researchers. Statistical community includes 98 websites of the Iranian State Universities of the Ministry of Health and Medical Education and Ministry of Science, Research and Technology and method of sampling is the census. Information was collected through observation and direct visits to websites and data analysis was prepared by Microsoft Excel software, 2011. The results of this study indicate that none of the websites use Dublin Core (DC) metadata and that only a few of them have used overlaps elements between HTML meta tags and Dublin Core (DC) elements. The percentage of overlaps of DC elements centralization in the Ministry of Health were 56% for both description and keywords and, in the Ministry of Science, were 45% for the keywords and 39% for the description. But, HTML meta tags have moderate presence in both Ministries, as the most-used elements were keywords and description (56%) and the least-used elements were date and formatter (0%). It was observed that the Ministry of Health and Ministry of Science follows the same path for using Dublin Core standard on their websites in the future. Because Central Library Websites are an example of scientific web pages, special attention in designing them can help the researchers to achieve faster and more accurate information resources

  8. Crystallization and preliminary X-ray crystallographic analysis of the GluR0 ligand-binding core from Nostoc punctiforme

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jun Hyuck; Park, Soo Jeong; Rho, Seong-Hwan; Im, Young Jun; Kim, Mun-Kyoung; Kang, Gil Bu; Eom, Soo Hyun, E-mail: eom@gist.ac.kr [Department of Life Science, Gwangju Institute of Science and Technology, Gwangju 500-712 (Korea, Republic of)

    2005-11-01

    The GluR0 ligand-binding core from N. punctiforme was expressed, purified and crystallized in the presence of l-glutamate. A diffraction data set was collected to a resolution of 2.1 Å. GluR0 from Nostoc punctiforme (NpGluR0) is a bacterial homologue of the ionotropic glutamate receptor. The ligand-binding core of NpGluR0 was crystallized at 294 K using the hanging-drop vapour-diffusion method. The l-glutamate-complexed crystal belongs to space group C222{sub 1}, with unit-cell parameters a = 78.0, b = 145.1, c = 132.1 Å. The crystals contain three subunits in the asymmetric unit, with a V{sub M} value of 2.49 Å{sup 3} Da{sup −1}. The diffraction limit of the l-glutamate complex data set was 2.1 Å using synchrotron X-ray radiation at beamline BL-4A of the Pohang Accelerator Laboratory (Pohang, Korea)

  9. Core domain and outcome measurement sets for shoulder pain trials are needed: Systematic review of physical therapy trials

    NARCIS (Netherlands)

    M.J. Page (Matthew J.); J.E. McKenzie (Joanne E.); S.E. Green (Sally E.); D.E. Beaton (Dorcas E.); N.B. Jain (Nitin B.); M. Lenza (Mario); A.P. Verhagen (Arianne P.); S. Surace (Stephen); J. Deitch (Jessica); R. Buchbinder (Rachelle)

    2015-01-01

    textabstractObjectives To explore the outcome domains and measurement instruments reported in published randomized controlled trials of physical therapy interventions for shoulder pain (rotator cuff disease, adhesive capsulitis, or nonspecific shoulder pain). Study Design and Setting We included tri

  10. Microsatellite diversity and broad scale geographic structure in a model legume: building a set of nested core collection for studying naturally occurring variation in Medicago truncatula

    DEFF Research Database (Denmark)

    Ronfort, Joelle; Bataillon, Thomas; Santoni, Sylvain

    2006-01-01

    scheme. Conclusion The stratification inferred is discussed considering potential historical events like expansion, refuge history and admixture between neighbouring groups. Information on the allelic richness and the inferred population structure are used to build a nested core-collection. The set......Abstract               Acknowledgements References   Background Exploiting genetic diversity requires previous knowledge of the extent and structure of the variation occurring in a species. Such knowledge can in turn be used to build a core-collection, i.e. a subset of accessions that aim...... at representing the genetic diversity of this species with a minimum of repetitiveness. We investigate the patterns of genetic diversity and population structure in a collection of 346 inbred lines representing the breadth of naturally occurring diversity in the Legume plant model Medicago truncatula using 13...

  11. The role of psychology in a pediatric outpatient cardiology setting: preliminary results from a new clinical program.

    Science.gov (United States)

    Brosig, Cheryl; Yang, Kai; Hoffmann, Raymond G; Dasgupta, Mahua; Mussatto, Kathleen

    2014-12-01

    The aim of this study was to provide a descriptive analysis of a new clinical program integrating psychology services within a pediatric outpatient cardiology clinic. Patients with congenital heart disease (CHD) (n = 79) were referred for psychological services by their pediatric cardiologist. Parents completed the child behavior checklist, and the pediatric quality of life inventory generic core scales (PedsQL parent report). Teachers completed the teacher report form. Reasons for referral included: emotional problems (29%); attention problems (25%); learning problems (22%); behavior problems (16%); and developmental delay (8%). Parents and teachers reported higher rates of behavior problems and lower quality of life scores than the general population. Psychological evaluation suggested that incorporating a psychologist within a pediatric cardiology clinic may be beneficial for children with CHD in order to optimize their psychosocial functioning. Practice implications for implementing psychology services within a pediatric outpatient cardiology program are discussed.

  12. A Preliminary Investigation of a Specialized Music Therapy Model for Children with Disabilities Delivered in a Classroom Setting

    Directory of Open Access Journals (Sweden)

    Jenna Mendelson

    2016-01-01

    Full Text Available Music therapy is gaining popularity as an intervention strategy for children with developmental disabilities, including autism spectrum disorder (ASD. This study was a pilot investigation of a classroom-based music-based intervention, Voices Together®, for improving communication skills in children with ASD and children with intellectual disabilities. Four local public elementary school special education classrooms, serving 5 children with a classification of autistic disorder and 32 children with intellectual disability without autism, were randomly selected to receive one of two levels of exposure to Voices Together music therapy: “long-term” (15 weeks beginning in January 2015 (Time 1, n=14 or “short-term” (7 weeks beginning 7 weeks later in February (Time 2, n=17. Using observational ratings, investigators reliably scored participants live in terms of their level of verbal responsiveness to prompts during three songs featured each week of the program. Both groups demonstrated increases in verbal responses over time; however, only the long-term group demonstrated significant within-group increases. Preliminary findings suggest that music therapy delivered in a classroom in 45-minute weekly sessions for 15 weeks can promote improvements in verbal responsiveness among individuals with autism and other developmental disabilities. Findings warrant further investigation into the efficacy of classroom-based music therapy programs.

  13. A Preliminary Investigation of a Specialized Music Therapy Model for Children with Disabilities Delivered in a Classroom Setting.

    Science.gov (United States)

    Mendelson, Jenna; White, Yasmine; Hans, Laura; Adebari, Richard; Schmid, Lorrie; Riggsbee, Jan; Goldsmith, Ali; Ozler, Burcu; Buehne, Kristen; Jones, Sarah; Shapleton, Jennifer; Dawson, Geraldine

    2016-01-01

    Music therapy is gaining popularity as an intervention strategy for children with developmental disabilities, including autism spectrum disorder (ASD). This study was a pilot investigation of a classroom-based music-based intervention, Voices Together®, for improving communication skills in children with ASD and children with intellectual disabilities. Four local public elementary school special education classrooms, serving 5 children with a classification of autistic disorder and 32 children with intellectual disability without autism, were randomly selected to receive one of two levels of exposure to Voices Together music therapy: "long-term" (15 weeks beginning in January 2015 (Time 1), n = 14) or "short-term" (7 weeks beginning 7 weeks later in February (Time 2), n = 17). Using observational ratings, investigators reliably scored participants live in terms of their level of verbal responsiveness to prompts during three songs featured each week of the program. Both groups demonstrated increases in verbal responses over time; however, only the long-term group demonstrated significant within-group increases. Preliminary findings suggest that music therapy delivered in a classroom in 45-minute weekly sessions for 15 weeks can promote improvements in verbal responsiveness among individuals with autism and other developmental disabilities. Findings warrant further investigation into the efficacy of classroom-based music therapy programs.

  14. A Preliminary Investigation of a Specialized Music Therapy Model for Children with Disabilities Delivered in a Classroom Setting

    Science.gov (United States)

    White, Yasmine; Hans, Laura; Adebari, Richard; Goldsmith, Ali; Ozler, Burcu; Buehne, Kristen; Jones, Sarah; Shapleton, Jennifer

    2016-01-01

    Music therapy is gaining popularity as an intervention strategy for children with developmental disabilities, including autism spectrum disorder (ASD). This study was a pilot investigation of a classroom-based music-based intervention, Voices Together®, for improving communication skills in children with ASD and children with intellectual disabilities. Four local public elementary school special education classrooms, serving 5 children with a classification of autistic disorder and 32 children with intellectual disability without autism, were randomly selected to receive one of two levels of exposure to Voices Together music therapy: “long-term” (15 weeks beginning in January 2015 (Time 1), n = 14) or “short-term” (7 weeks beginning 7 weeks later in February (Time 2), n = 17). Using observational ratings, investigators reliably scored participants live in terms of their level of verbal responsiveness to prompts during three songs featured each week of the program. Both groups demonstrated increases in verbal responses over time; however, only the long-term group demonstrated significant within-group increases. Preliminary findings suggest that music therapy delivered in a classroom in 45-minute weekly sessions for 15 weeks can promote improvements in verbal responsiveness among individuals with autism and other developmental disabilities. Findings warrant further investigation into the efficacy of classroom-based music therapy programs. PMID:27999683

  15. Independent evolution of the core and accessory gene sets in the genus Neisseria: insights gained from the genome of Neisseria lactamica isolate 020-06

    Directory of Open Access Journals (Sweden)

    White Brian

    2010-11-01

    Full Text Available Abstract Background The genus Neisseria contains two important yet very different pathogens, N. meningitidis and N. gonorrhoeae, in addition to non-pathogenic species, of which N. lactamica is the best characterized. Genomic comparisons of these three bacteria will provide insights into the mechanisms and evolution of pathogenesis in this group of organisms, which are applicable to understanding these processes more generally. Results Non-pathogenic N. lactamica exhibits very similar population structure and levels of diversity to the meningococcus, whilst gonococci are essentially recent descendents of a single clone. All three species share a common core gene set estimated to comprise around 1190 CDSs, corresponding to about 60% of the genome. However, some of the nucleotide sequence diversity within this core genome is particular to each group, indicating that cross-species recombination is rare in this shared core gene set. Other than the meningococcal cps region, which encodes the polysaccharide capsule, relatively few members of the large accessory gene pool are exclusive to one species group, and cross-species recombination within this accessory genome is frequent. Conclusion The three Neisseria species groups represent coherent biological and genetic groupings which appear to be maintained by low rates of inter-species horizontal genetic exchange within the core genome. There is extensive evidence for exchange among positively selected genes and the accessory genome and some evidence of hitch-hiking of housekeeping genes with other loci. It is not possible to define a 'pathogenome' for this group of organisms and the disease causing phenotypes are therefore likely to be complex, polygenic, and different among the various disease-associated phenotypes observed.

  16. A Case Based Analysis Preparation Strategy for Use in a Classroom Management for Inclusive Settings Course: Preliminary Observations

    Science.gov (United States)

    Niles, William J.; Cohen, Alan

    2012-01-01

    Case based instruction (CBI) is a pedagogical option in teacher preparation growing in application but short on practical means to implement the method. This paper presents an analysis strategy and questions developed to help teacher trainees focus on classroom management issues embedded in a set of "real" cases. An analysis of teacher candidate…

  17. Stratigraphy, correlation, depositional setting, and geophysical characteristics of the Oligocene Snowshoe Mountain Tuff and Creede Formation in two cored boreholes

    Science.gov (United States)

    Larsen, Daniel; Nelson, Philip H.

    2000-01-01

    Core descriptions and geophysical logs from two boreholes (CCM-1 and CCM-2) in the Oligocene Snowshoe Mountain Tuff and Creede Formation, south-central Colorado, are used to interpret sedimentary and volcanic facies associations and their physical properties. The seven facies association include a mixed sequence of intracaldera ash-flow tuffs and breccias, alluvial and lake margin deposits, and tuffaceous lake beds. These deposits represent volcanic units related to caldera collapse and emplacement of the Snowshoe Mountain Tuff, and sediments and pyroclastic material deposited in the newly formed caldera basin, Early sedimentation is interpreted to have been rapid, and to have occurred in volcaniclastic fan environments at CCM-1 and in a variery of volcaniclastic fan, braided stream shallow lacustrine, and mudflat environments at CCM-2. After an initial period of lake-level rise, suspension settling, turbidite, and debris-flow sedimentation occurred in lacustrine slope and basin environments below wave base. Carbonate sedimentation was initially sporadic, but more continuous in the latter part of the recorded lake history (after the H fallout tuff). Sublacustrine-fan deposition occurred at CCM-1 after a pronounced lake-level fall and subsequent rise that preceded the H tuff. Variations in density, neutron, gamma-ray, sonic, and electrical properties of deposits penetrated oin the two holes reflect variations in lithology, porosity, and alteration. Trends in the geophysical properties of the lacustrine strata are linked to downhole changes in authigenic mineralology and a decrease in porosity interpreted to have resulted primarily from diagenesis. Lithological and geophysical characteristics provide a basis for correlation of the cores; however, mineralogical methods of correlation are hampered by the degree of diagenesis and alteration.

  18. An algebraic framework for the greedy algorithm with applications to the core and Weber set of cooperative games

    NARCIS (Netherlands)

    Faigle, U.; Kern, Walter

    1998-01-01

    An algebraic model generalizing submodular polytopes is presented, where modular functions on partially ordered sets take over the role of vectors in ${\\mathbb R}^n$. This model unifies various generalizations of combinatorial models in which the greedy algorithm and the Monge algorithm are

  19. An order-theoretic framework for the greedy algorithm with applications to the core and Weber Set of cooperative games

    NARCIS (Netherlands)

    Faigle, U.; Kern, Walter

    2000-01-01

    An algebraic model generalizing submodular polytopes is presented, where modular functions on partially ordered sets take over the role of vectors in Rn. This model unifies various generalizations of combinatorial models in which the greedy algorithm and the Monge algorithm are successful and

  20. Do Patient-Reported Outcome Measures describe functioning in patients with low back pain, using the Brief International Classification of Functioning, Disability and Health Core Set as a reference?

    DEFF Research Database (Denmark)

    Ibsen, Charlotte; Schiøttz-Christensen, Berit; Melchiorsen, Hanne

    2016-01-01

    OBJECTIVE: To link the items in the Patient-Reported Outcome Measures (PROMs): Roland Morris Disability Questionnaire, Short Form 36 (SF-36) and pain scores, to the Brief International Classification of Functioning, Disability and Health (ICF) Core Set for low back pain, and to examine the extent...... to which a clinician's assessment of patients' problems according to the Brief ICF Core Set correlates with the scores of matching items from the PROMs. METHODS: The PROMs were linked to the Brief ICF Core Set for low back pain. Secondly, a cross-sectional study was conducted including 70 patients with low...... back pain. The patients completed the PROMs, and the Brief ICF Core Set for low back pain was assessed by a clinician using qualifiers. RESULTS: The items in the PROMs were successfully linked to the ICF. Twelve of the 38 unique ICF categories derived from the PROMs were covered by the Brief ICF Core...

  1. Preliminary adaptation into Portuguese of a standardised picture set for the use in research and neuropsychological assessment

    Directory of Open Access Journals (Sweden)

    POMPÉIA SABINE

    1998-01-01

    Full Text Available Pictorial stimuli and words have been widely used to evaluate mnemonic processes in clinical settings, neuropsychological investigations, as well as in studies on the mechanisms underlying the phenomena of memory. However, there seem to be few studies of standardisation of pictures for research in this field. The present paper aimed at adapting the use of a set of pictures standardised for English speaking subjects for Portuguese speakers. Name agreement of 150 pictures was assessed in 100 high-school students. Ninety pictures were found to present the same name for over 90 subjects. Results yield data that may help create more controlled tests for the study of memory for pictorial stimuli in Brazil.

  2. A wavelet-based Projector Augmented-Wave (PAW) method: Reaching frozen-core all-electron precision with a systematic, adaptive and localized wavelet basis set

    Science.gov (United States)

    Rangel, T.; Caliste, D.; Genovese, L.; Torrent, M.

    2016-11-01

    We present a Projector Augmented-Wave (PAW) method based on a wavelet basis set. We implemented our wavelet-PAW method as a PAW library in the ABINIT package [http://www.abinit.org] and into BigDFT [http://www.bigdft.org]. We test our implementation in prototypical systems to illustrate the potential usage of our code. By using the wavelet-PAW method, we can simulate charged and special boundary condition systems with frozen-core all-electron precision. Furthermore, our work paves the way to large-scale and potentially order- N simulations within a PAW method.

  3. A wavelet-based Projector Augmented-Wave (PAW) method: reaching frozen-core all-electron precision with a systematic, adaptive and localized wavelet basis set

    CERN Document Server

    Rangel, Tonatiuh; Genovese, Luigi; Torrent, Marc

    2016-01-01

    We present a Projector Augmented-Wave~(PAW) method based on a wavelet basis set. We implemented our wavelet-PAW method as a PAW library in the ABINIT package [http://www.abinit.org] and into BigDFT [http://www.bigdft.org]. We test our implementation in prototypical systems to illustrate the potential usage of our code. By using the wavelet-PAW method, we can simulate charged and special boundary condition systems with frozen-core all-electron precision. Furthermore, our work paves the way to large-scale and potentially order-N simulations within a PAW method.

  4. Identification of a core set of 58 gene transcripts with broad and specific expression in the microvasculature.

    Science.gov (United States)

    Wallgard, Elisabet; Larsson, Erik; He, Liqun; Hellström, Mats; Armulik, Annika; Nisancioglu, Maya H; Genove, Guillem; Lindahl, Per; Betsholtz, Christer

    2008-08-01

    Pathological angiogenesis is an integral component of many diseases. Antiangiogenesis and vascular targeting are therefore promising new therapeutic principles. However, few endothelial-specific putative drug targets have been identified, and information is still limited about endothelial-specific molecular processes. Here we aimed at determining the endothelial cell-specific core transcriptome in vivo. Analysis of publicly available microarray data identified a mixed vascular/lung cluster of 132 genes that correlated with known endothelial markers. Filtering against kidney glomerular/nonglomerular and brain vascular/nonvascular microarray profiles separated contaminating lung markers, leaving 58 genes with broad and specific microvascular expression. More than half of these have not previously been linked to endothelial functions or studied in detail before. The endothelial cell-specific expression of a selected subset of these, Eltd1, Gpr116, Ramp2, Slc9a3r2, Slc43a3, Rasip1, and NM_023516, was confirmed by real-time quantitative polymerase chain reaction and/or immunohistochemistry. We have used a combination of publicly available and own microarray data to identify 58 gene transcripts with broad yet specific expression in microvascular endothelium. Most of these have unknown functions, but many of them are predicted to be cell surface expressed or implicated in cell signaling processes and should therefore be explored as putative microvascular drug targets.

  5. Auxiliary basis sets for density-fitting second-order Møller-Plesset perturbation theory: weighted core-valence correlation consistent basis sets for the 4d elements Y-Pd.

    Science.gov (United States)

    Hill, J Grant

    2013-09-30

    Auxiliary basis sets (ABS) specifically matched to the cc-pwCVnZ-PP and aug-cc-pwCVnZ-PP orbital basis sets (OBS) have been developed and optimized for the 4d elements Y-Pd at the second-order Møller-Plesset perturbation theory level. Calculation of the core-valence electron correlation energies for small to medium sized transition metal complexes demonstrates that the error due to the use of these new sets in density fitting is three to four orders of magnitude smaller than that due to the OBS incompleteness, and hence is considered negligible. Utilizing the ABSs in the resolution-of-the-identity component of explicitly correlated calculations is also investigated, where it is shown that i-type functions are important to produce well-controlled errors in both integrals and correlation energy. Benchmarking at the explicitly correlated coupled cluster with single, double, and perturbative triple excitations level indicates impressive convergence with respect to basis set size for the spectroscopic constants of 4d monofluorides; explicitly correlated double-ζ calculations produce results close to conventional quadruple-ζ, and triple-ζ is within chemical accuracy of the complete basis set limit.

  6. Clinical experience with fortnightly buprenorphine/naloxone versus buprenorphine in Italy: preliminary observational data in an office-based setting.

    Science.gov (United States)

    Amato, Patrizia

    2010-01-01

    Buprenorphine/naloxone is a new option for the management of opioid dependence. It has a reduced potential for abuse or misuse compared with methadone and buprenorphine alone, and has a long half-life allowing less frequent dosing. Buprenorphine/naloxone appears to be well suited for the management of opioid dependence in an office-based setting. The aim of this study was to evaluate the efficacy and safety of a buprenorphine/naloxone combination treatment in an office-based setting. Therefore, we evaluated the effect on misuse/diversion, quality of care, quality of life and service delivery. Seventy-eight patients were switched to buprenorphine/naloxone from either methadone or buprenorphine alone; the median duration of previous buprenorphine or methadone treatment was 10 years. Patients received buprenorphine/naloxone and were evaluated throughout a 1-year follow-up period. Treatment was self-administered by the patients every 2 weeks and the mean buprenorphine dosage at 1 year was 8 mg/day. Comparisons were made before and after the switch for patients who switched from buprenorphine alone to buprenorphine/naloxone. Switching to buprenorphine/naloxone was not associated with clinically relevant problems in 50% of patients studied. Buprenorphine/naloxone provided satisfactory coverage of withdrawal symptoms in 78.1% of patients, and 50% of patients were satisfied with buprenorphine/naloxone therapy. Seventy-eight per cent of patients reported improved psychosocial functioning. The majority of patients (approximately 85%) were negative for opioids during toxicological testing. A significantly higher proportion of treatment recipients were highly satisfied during buprenorphine/naloxone administration (p buprenorphine given before the switch). Other outcomes were similar during buprenorphine and buprenorphine/naloxone administration. Fortnightly self-administration of buprenorphine/naloxone appeared to be cost saving for the clinic. Buprenorphine/naloxone is an

  7. Forceful Emplacement of Granitic Plutons in an Extensional Tectonic Setting: Syn-kinematic Plutons in the Yagan-Onch Hayrhan Metamorphic Core Complex

    Institute of Scientific and Technical Information of China (English)

    王涛; 郑亚东; 李天兵; 高永军; 马铭波

    2002-01-01

    It is generally considered that granitic plutons are forcefully emplaced in a compressional setting and permissively emplaced in an extensional setting. This paper, however, shows that syn-kinematic (extensional) elliptic granitic plutons in the Yagan-Onch Hayrhan metamorphic core complex (MCC) have relatively strong forceful emplacement, which are indicated by (1) concentric distribution of the rock units, (2) a strain pattern with strong strains on the margins and low strains at the centre of a pluton, and particularly (3) syn-emplacement shortening of the host rocks within the aureole. The strain analysis for the host rocks shows that the host-rock ductile shortening, I.e. Forceful emplacement, provides about 16?24% of the emplacement space for the present plutons. All these suggest that forceful emplacement occurs not only in a compressional tectonic setting, but also in an extensional setting. This study further demonstrates the significance of the multiple emplacement of granitic plutons and provides new information about the causality between granitic magmatism and the formation of the MCC and its dynamics.

  8. A preliminary phylogeny of the 'didymocarpoid Gesneriaceae' based on three molecular data sets: Incongruence with available tribal classifications.

    Science.gov (United States)

    Möller, Michael; Pfosser, Martin; Jang, Chang-Gee; Mayer, Veronika; Clark, Alexandra; Hollingsworth, Michelle L; Barfuss, Michael H J; Wang, Yin-Zheng; Kiehn, Michael; Weber, Anton

    2009-05-01

    The 'didymocarpoid Gesneriaceae' (traditional subfam. Cyrtandroideae excluding Epithemateae) are the largest group of Old World Gesneriaceae, comprising 85 genera and 1800 species. We attempt to resolve their hitherto poorly understood generic relationships using three molecular markers on 145 species, of which 128 belong to didymocarpoid Gesneriaceae. Our analyses demonstrate that consistent topological relationships can be retrieved from data sets with missing data using subsamples and different combinations of gene sequences. We show that all available classifications in Old World Gesneriaceae are artificial and do not reflect natural relationships. At the base of the didymocarpoids are grades of clades comprising isolated genera and small groups from Asia and Europe. These are followed by a clade comprising the African and Madagascan genera. The remaining clades represent the advanced Asiatic and Malesian genera. They include a major group with mostly twisted capsules. The much larger group of remaining genera comprises exclusively genera with straight capsules and the huge genus Cyrtandra with indehiscent fruits. Several genera such as Briggsia, Henckelia, and Chirita are not monophyletic; Chirita is even distributed throughout five clades. This degree of incongruence between molecular phylogenies, traditional classifications, and generic delimitations indicates the problems with classifications based on, sometimes a single, morphological characters.

  9. Prenatal detection of aneuploidies using fluorescence in situ hybridization: A preliminary experience in an Indian set up

    Indian Academy of Sciences (India)

    Vaidehi Jobanputra; Kalol Kumar Roy; Kiran Kucheria

    2002-03-01

    Fluorescence in situ hybridization (FISH) is a powerful molecular cytogenetic technique which allows rapid detection of aneuploidies on interphase cells and metaphase spreads. The aim of the present study was to evaluate FISH as a tool in prenatal diagnosis of aneuploidies in high risk pregnancies in an Indian set up. Prenatal diagnosis was carried out in 88 high-risk pregnancies using FISH and cytogenetic analysis. Multicolour commercially available FISH probes specific for chromosomes 13, 18, 21, X and Y were used. Interphase FISH was done on uncultured cells from chorionic villus and amniotic fluid samples. FISH on metaphase spreads was done from cord blood samples. The results of FISH were in conformity with the results of cytogenetic analysis in all the normal and aneuploid cases except in one case of structural chromosomal abnormality. The hybridization efficiency of the 5 probes used for the detection of aneuploidies was 100%. Using these probes FISH assay yielded discrete differences in the signal profiles between cytogenetically normal and abnormal samples. The overall mean interphase disomic signal patterns of chromosomes 13, 18, 21, X and Y were 94.45%; for interphase trisomic signal pattern of chromosome 21 was 97.3%. Interphase FISH is very useful in urgent high risk cases. The use of FISH overcomes the difficulties of conventional banding on metaphase spreads and reduces the time of reporting. However, with the limited number of probes used, the conventional cytogenetic analysis serves as a gold standard at present. It should be employed as an adjunctive tool to conventional cytogenetics.

  10. Canadian valuation of EQ-5D health states: preliminary value set and considerations for future valuation studies.

    Directory of Open Access Journals (Sweden)

    Nick Bansback

    Full Text Available BACKGROUND: The EQ-5D is a preference based instrument which provides a description of a respondent's health status, and an empirically derived value for that health state often from a representative sample of the general population. It is commonly used to derive Quality Adjusted Life Year calculations (QALY in economic evaluations. However, values for health states have been found to differ between countries. The objective of this study was to develop a set of values for the EQ-5D health states for use in Canada. METHODS: Values for 48 different EQ-5D health states were elicited using the Time Trade Off (TTO via a web survey in English. A random effect model was fitted to the data to estimate values for all 243 health states of the EQ-5D. Various model specifications were explored. Comparisons with EQ-5D values from the UK and US were made. Sensitivity analysis explored different transformations of values worse than dead, and exclusion criteria of subjects. RESULTS: The final model was estimated from the values of 1145 subjects with socio-demographics broadly representative of Canadian general population with the exception of Quebec. This yielded a good fit with observed TTO values, with an overall R2 of 0.403 and a mean absolute error of 0.044. CONCLUSION: A preference-weight algorithm for Canadian studies that include the EQ-5D is developed. The primary limitations regarded the representativeness of the final sample, given the language used (English only, the method of recruitment, and the difficulty in the task. Insights into potential issues for conducting valuation studies in countries as large and diverse as Canada are gained.

  11. Linking of the Patient Rated Elbow Evaluation (PREE) and the American Shoulder and Elbow Surgeons - Elbow questionnaire (pASES-e) to the International Classification of Functioning Disability and Health (ICF) and Hand Core Sets.

    Science.gov (United States)

    Vincent, Joshua I; MacDermid, Joy C; King, Graham J W; Grewal, Ruby

    2015-01-01

    Content analysis-ICF linking. The Patient Rated Elbow Evaluation (PREE) and the self-report section of the American Shoulder and Elbow Surgeons society - Elbow form (ASES-e) are the two commonly used elbow pain and disability self-report measures (PROs). The content of these questions have never been analyzed in light of the International Classification of Functioning Disability and Health (ICF) which is the current standard to describe health and health-related states. The purposes of this study were to analyze the conceptual basis of the PREE and the ASES-e by linking the meaningful concepts in these PROs to the ICF using standardized linking rules and to determine the extent to which the ICF core set for hand conditions cover the content of elbow questionnaires using summary ICF linkage indicators. Two raters linked the two PROs to the ICF using the linking rules proposed by Cieza and colleagues. Percentage agreement was calculated between the raters. Summary linkage indicators proposed by MacDermid were used to estimate the extent to which the ICF core set for hand conditions cover the content of the elbow questionnaires. All the items of the PREE (Measure to ICF linkage - 100%) and all but one item of the pASES-e (Measure to ICF linkage - 95%) were linked to the ICF. The satisfaction item on the ASES-e was not-covered by the ICF. Percentage agreement on linking between the raters was 96% and 95% for the PREE and the pASES-e respectively. The unique linkage of the PREE and the pASES-e to the unique codes on the brief and comprehensive core set were lower than absolute linkage to the core set for hand conditions. The PROs represented less than 20% of the comprehensive core set and more than 70% of the brief core set. While for the unique core set disability representation the 2 PROMs represented 100% brief core set unique disability codes and less than 35% of the comprehensive core set unique disability codes. The PREE and the ASES-e are aligned with the ICF

  12. MRI-guided breast biopsy at 3T using a dedicated large core biopsy set: Feasibility and initial results

    Energy Technology Data Exchange (ETDEWEB)

    Meeuwis, Carla, E-mail: cmeeuwis@alysis.nl [Department of Radiology, Radboud University Nijmegen Medical Centre, Geert Grooteplein-Zuid 10, 6525GA Nijmegen (Netherlands); Department of Radiology, Rijnstate Hospital, Alysis Zorggroep, Wagnerlaan 55, 6815 AD Arnhem (Netherlands); Mann, Ritse M., E-mail: r.mann@rad.umcn.nl [Department of Radiology, Radboud University Nijmegen Medical Centre, Geert Grooteplein-Zuid 10, 6525GA Nijmegen (Netherlands); Mus, Roel D.M., E-mail: r.mus@rad.umcn.nl [Department of Radiology, Radboud University Nijmegen Medical Centre, Geert Grooteplein-Zuid 10, 6525GA Nijmegen (Netherlands); Winkel, Axel, E-mail: awinkel@invivocorp.de [Interventional Instruments, INVIVO Germany GMBH, Schwerin (Germany); Boetes, Carla, E-mail: c.boetes@mumc.nl [Department of Radiology, Radboud University Nijmegen Medical Centre, Geert Grooteplein-Zuid 10, 6525GA Nijmegen (Netherlands); Department of Radiology, Maastricht University Medical Center (Netherlands); Barentsz, Jelle O., E-mail: j.barentsz@rad.umcn.nl [Department of Radiology, Radboud University Nijmegen Medical Centre, Geert Grooteplein-Zuid 10, 6525GA Nijmegen (Netherlands); Veltman, Jeroen, E-mail: veltman@rad.umcn.nl [Department of Radiology, Radboud University Nijmegen Medical Centre, Geert Grooteplein-Zuid 10, 6525GA Nijmegen (Netherlands)

    2011-08-15

    Objective: The increasing importance of breast MRI in the diagnostic processes concerning breast cancer yield often lesions that are visible on MRI only. To assess the nature of these lesions, pathologic analysis is necessary. Therefore, MR-guided biopsy should be available. Breast MRI at 3T has shown advantage over 1.5T. Unfortunately, current equipment for MR-guided biopsy is better suited for intervention at 1.5T due to the danger of heating titanium co-axial sleeves and large susceptibility artifacts. We evaluated a dedicated 3T breast biopsy set that uses plastic coaxial needles to overcome these problems. Materials and methods: We performed MRI-guided breast biopsy in 23 women with 24 MRI-only visible breast lesions at 3T. Biopsy procedures were performed with plastic coaxial needles in a closed bore 3T clinical MR system on a dedicated phased array breast coil with a commercially available add-on stereotactic biopsy device. Results: Width of the needle artifact was 2 mm in all 24 cases. Biopsy procedure was completed between 35 and 67 min. The procedure was judged moderately easy in 12 and normal in 10 cases. One procedure was judged difficult and there was one technical failure. Conclusion: MRI-guided breast biopsy at 3T is a fast and accurate procedure. The plastic coaxial needles reduce the susceptibility artifact largely and do not increase the difficulty of the procedure. The diagnostic yield is at least equal to the diagnostic yield of the same procedure at 1.5T. Therefore, this technique can be safely used for lesions only visible at 3T MRI.

  13. Therapeutic strategies evaluated by the European Society of Cutaneous Lupus Erythematosus (EUSCLE) Core Set Questionnaire in more than 1000 patients with cutaneous lupus erythematosus

    DEFF Research Database (Denmark)

    Sigges, Johanna; Biazar, Cyrus; Landmann, Aysche

    2013-01-01

    The aim of this prospective, cross-sectional, multicentre study performed by the European Society of Cutaneous Lupus Erythematosus (EUSCLE) was to investigate different therapeutic strategies and their efficacies in cutaneous lupus erythematosus (CLE) throughout Europe. Using the EUSCLE Core Set...... Questionnaire, topical and systemic treatment options were analysed in a total of 1002 patients (768 females and 234 males) with different CLE subtypes. The data were correlated with the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) and the criteria of the American College...... of Rheumatology (ACR) for the classification of systemic lupus erythematosus. Sunscreens were applied by 84.0% of the study cohort and showed a high efficacy in preventing skin lesions in all disease subtypes, correlating with a lower CLASI activity score. Topical steroids were used in 81.5% of the patients...

  14. Feasibility of using training cases from International Spinal Cord Injury Core Data Set for testing of International Standards for Neurological Classification of Spinal Cord Injury items

    DEFF Research Database (Denmark)

    Liu, N; Hu, Z W; Zhou, M W;

    2014-01-01

    STUDY DESIGN: Descriptive comparison analysis. OBJECTIVE: To evaluate whether five training cases of International Spinal Cord Injury Core Data Set (ISCICDS) are appropriate for testing the facts within the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI......) and could thus be used for testing its training effectiveness. METHODS: The authors reviewed the five training cases from the ISCICDS and determined the sensory level (SL), motor level (ML) and American Spinal Injury Association Impairment Scale (AIS) for the training cases. The key points from the training...... cases were compared with our interpretation of the key aspects of the ISNCSCI. RESULTS: For determining SL, three principles of ML, sacral sparing, complete injury, classification of AIS A, B, C and D, determining motor incomplete status through sparing of motor function more than three levels below...

  15. Afatinib in first-line setting for NSCLC harbouring common EGFR mutations: new light after the preliminary results of LUX-Lung 7?

    Science.gov (United States)

    Passaro, Antonio; Pochesci, Alessia; Spitaleri, Gianluca; Catania, Chiara; Noberasco, Cristina; Del Signore, Ester; de Marinis, Filippo

    2016-03-01

    The development of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) changed dramatically the history of non-small cell lung cancer (NSCLC) harboring EGFR sensitive mutations. Several randomized prospective trials confirmed the superiority of these target agents about survival and response rate when comparing with platinum-based chemotherapy. Knowledge about EGFR mutations increased gradually during the development of target agents and different clinical trials. EGFR mutations cannot be considered all equal, but different entities should be considered in our clinical practice: exon 19 deletions, exon 21 mutation (L858R) and uncommon mutation (exon 20, exon 18 and double mutation). Nowadays, we dispose of three different EGFR TKIs (afatinib, erlotinib and gefitinib) approved for the treatment for first-line treatment of patients di NSCLC carrying EGFR, that was compared only by indirect analysis, producing data not always clear and convincing. This research highlight is an overview of data about EGFR TKIs in first-line setting, focusing on differences about exon 19 deletions and L585R mutation in patients treated with different TKIs. In addition, we report the preliminary results of the first head-to-head randomized clinical trial between two different EGFR TKIs, the LUX-Lung 7 (LL7) that compared afatinib and gefitinib showing interesting results.

  16. CHIPRA Updated Child Core Set

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Childrens Health Insurance Program Reauthorization Act of 2009 (CHIPRA) included provisions to strengthen the quality of care provided to and health outcomes of...

  17. Most lobular carcinoma in situ and atypical lobular hyperplasia diagnosed on core needle biopsy can be managed clinically with radiologic follow-up in a multidisciplinary setting.

    Science.gov (United States)

    Middleton, Lavinia P; Sneige, Nour; Coyne, Robin; Shen, Yu; Dong, Wenli; Dempsey, Peter; Bevers, Therese B

    2014-06-01

    We evaluated the efficacy of using standard radiologic and histologic criteria to guide the follow-up of patients with lobular carcinoma in situ (LCIS), lobular neoplasia (LN), or atypical lobular hyperplasia (ALH). Patients with high-risk benign lesions diagnosed on biopsy were presented and reviewed in a multidisciplinary clinical management conference from 1 November 2003 through September 2011. Associations between patient characteristics and rates of upgrade were determined by univariate and multivariate logistic models, and times to diagnosis carcinoma were calculated. Of 853 cases reviewed, 124 (14.5%) were lobular neoplasms. In all, 104 patients were clinically and/or radiographically monitored. In 20 patients, who were found to have LN on core biopsy and were recommended to have immediate surgical excision, a more significant lesion was identified in 8 (40%) of the excised specimens. Factors associated with a more significant lesion on excisional biopsy included whether the lobular lesion had been targeted for biopsy and whether the extent of disease involved three or more terminal duct lobular units. Of the 104 patients radiographically and clinically monitored, the median follow-up time was 3.4 years with a range of 0.44-8.6 years. Five patients under surveillance were subsequently diagnosed with breast malignancy (three of the five at a site unrelated to the initial biopsy). Patients with incidental lobular lesions identified on percutaneous core needle biopsy have a small risk of upgrade and may not require an excisional biopsy. Clinical management of low-volume lobular lesions in a multidisciplinary setting is an efficacious alternative to surgical excision when radiologic and histologic characteristics are well-defined.

  18. Influence of image acquisition settings on radiation dose and image quality in coronary angiography by 320-detector volume computed tomography: the CORE320 pilot experience

    Directory of Open Access Journals (Sweden)

    Armin Arbab-Zadeh

    2012-06-01

    Full Text Available The objective of this study was to investigate the impact of image acquisition settings and patients’ characteristics on image quality and radiation dose for coronary angiography by 320-row computed tomography (CT. CORE320 is a prospective study to investigate the diagnostic performance of 320-detector CT for detecting coronary artery disease and associated myocardial ischemia. A run-in phase in 65 subjects was conducted to test the adequacy of the computed tomography angiography (CTA acquisition protocol. Tube current, exposure window, and number of cardiac beats per acquisition were adjusted according to subjects’ gender, heart rate, and body mass index (BMI. Main outcome measures were image quality, assessed by contrast/noise measurements and qualitatively on a 4-point scale, and radiation dose, estimated by the dose-length-product. Average heart rate at image acquisition was 55.0±7.3 bpm. Median Agatston calcium score was 27.0 (interquartile range 1-330. All scans were prospectively triggered. Single heart beat image acquisition was obtained in 61 of 65 studies (94%. Sixty-one studies (94% and 437 of 455 arterial segments (96% were of diagnostic image quality. Estimated radiation dose was significantly greater in obese (5.3±0.4 mSv than normal weight (4.6±0.3 mSv or overweight (4.7±0.3 mSv subjects (P<0.001. BMI was the strongest factor influencing image quality (odds ratio=1.457, P=0.005. The CORE320 CTA image acquisition protocol achieved a good balance between image quality and radiation dose for a 320-detector CT system. However, image quality in obese subjects was reduced compared to normal weight subjects, possibly due to tube voltage/current restrictions mandated by the study protocol.

  19. Preliminary results of the close-off depth and the stable isotopic records along a 109.91 m ice core from Dome A, Antarctica

    Institute of Scientific and Technical Information of China (English)

    HOU ShuGui; LI YuanSheng; XIAO CunDe; PANG HongXi; XU JianZhong

    2009-01-01

    A 109.91 m ice core was recovered from Dome A (or Dome Argus), the highest ice feature in Antarctica,during the 2004/05 austral summer by the 21st Chinese National Antarctic Research Expedition (CHINARE-21). Both methane profile along the core and firn densification model calculation suggest that the close-off depth is at about 102.0 m with an ice age about 4200 a. Stable isotopes (δ~(18)O and δD) of the chips samples produced during each run of ice core drilling at Dome A, together with those of the other cores recovered from the eastern inland Antarctica, suggest a relative stable climate with a tem-perature fluctuation amplitude about ±0.6℃ at the eastern inland Antarctica during the late Holocene.The average d-excess (or d=δD-8δ~(18)O) of 17.1‰ along the Dome A core is probably the highest among the Antarctic inland ice cores, which may be resulted from the kinetic fractionation during the snow formation under an oversaturation condition. Moreover, the increasing trend of d-excess during the late Holocene reflects mainly the migration of the water source area for precipitation at Dome A towards low latitudes. This paper presents the first results of a shallow ice core recovered from the unexplored highest area of the Antarctic ice sheet, providing a background for the proposing deep ice core drilling at Dome A.

  20. Preliminary results of the close-off depth and the stable isotopic records along a 109.91 m ice core from Dome A, Antarctica

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    A 109.91 m ice core was recovered from Dome A (or Dome Argus), the highest ice feature in Antarctica, during the 2004/05 austral summer by the 21st Chinese National Antarctic Research Expedition (CHINARE-21). Both methane profile along the core and firn densification model calculation suggest that the close-off depth is at about 102.0 m with an ice age about 4200 a. Stable isotopes (δ18O and δD) of the chips samples produced during each run of ice core drilling at Dome A, together with those of the other cores recovered from the eastern inland Antarctica, suggest a relative stable climate with a temperature fluctuation amplitude about ±0.6℃ at the eastern inland Antarctica during the late Holocene. The average d-excess (or d =δ D-8δ 18O) of 17.1‰ along the Dome A core is probably the highest among the Antarctic inland ice cores, which may be resulted from the kinetic fractionation during the snow formation under an oversaturation condition. Moreover, the increasing trend of d-excess during the late Holocene reflects mainly the migration of the water source area for precipitation at Dome A towards low latitudes. This paper presents the first results of a shallow ice core recovered from the unexplored highest area of the Antarctic ice sheet, providing a background for the proposing deep ice core drilling at Dome A.

  1. The feasibility of implementing an evidence-based core set of clinical pharmacy services in 2020: manpower, marketplace factors, and pharmacy leadership.

    Science.gov (United States)

    Bond, C A; Raehl, Cynthia L; Patry, Roland

    2004-04-01

    Development of a national plan to implement a core set of clinical pharmacy services in United States hospitals by 2020 requires assertive leadership from pharmacy organizations and state boards of pharmacy, and a commitment from the profession. Factors that may affect the development are grouped into three areas: manpower, marketplace variables, and pharmacy leadership. Although the number of pharmacy school graduates (7000) was about the same in 1990 and 2000, a greater number of pharmacy schools and high student enrollment, coupled with the Accreditation Council for Pharmacy Education's acceptance of foreign-trained pharmacists, suggest that the number of pharmacists will increase substantially in the near future. We estimate that the net increase in pharmacists (new pharmacy graduates less pharmacists who retire or die) in the United States will be 139,929 from 2000-2020, for a total of 335,040 pharmacists (71% increase). The number of pharmacy technicians increased substantially (66%), from 150,000 in 1996 to 250,000 in 2002. The number of residents in programs accredited by the American Society of Health-System Pharmacists increased 148%, from 435 in 1990 to 1080 in 2002. We conservatively project an increase of 33,000 pharmacists who complete residencies from 2000-2020. The pharmacy marketplace has changed dramatically over the last 12 years, with 10,754 independent community pharmacies closing (2.46 pharmacies/day) and 8459 chain outlets opening (1.93 chains/day). In recent years, mail-order pharmacies have expanded faster than other retail outlets and now process over 18% of U.S. prescriptions. Increased use of robotic systems (some can process 5000 prescriptions/hr) and technicians will diminish the demand for dispensing pharmacists. In addition, up to 10% of U.S. retail prescriptions may be filled outside the country's borders. These data indicate that there will be a sufficient supply of pharmacists and technicians in the future. Thus, it is feasible

  2. Coronary Artery Disease Risk Factors in an Urban and Peri-urban Setting, Kerman, Southeastern Iran (KERCADR Study: Methodology and Preliminary Report

    Directory of Open Access Journals (Sweden)

    S Navadeh

    2012-09-01

    Full Text Available Background: This article was to present the sampling and measurements methods and the main preliminary findings of the KERCADR cohort study (first round in an urban and peri-urban setting, Kerman, southeastern Iran2009-11. Method: 5900 (3238 female people aged between 15 to 75 years were recruited in the household survey by non-proportional to size one-stage cluster sampling. Trained internal specialists, general practitioners, clinical psychologists and dentists have assessed the study subjects by person-assisted questionnaires regarding different NCD risk factors including cigarette and opium smoking, physical activity, nutrition habits, anxiety, depression, obesity, hypertension and oral health. Blood samples were also collected for determining FBS, HbA1c, cholesterol and triglyceride. Weighted standardized prevalence estimates were calculated by STATA 10 survey analysis package. Results: The participation rate was more than 95% in all subgroups. Cigarette smoking (18.4% vs. 1.2%, opium use (17.8% vs. 3.0% and triglyceridemia (16.1% vs. 12.0% were significantly higher among men than women. In contrast, women were presented with higher level of sever anxiety (29.1% vs. 16.7%, obesity (16.8% vs. 9.2%, low-physical activity (45.1% vs. 39.2% and uncontrolled diabetes (60.2% vs. 31.0%. More than 68% of all subjects have presented with moderate to severe gingival index scores. Conclusion: The first round of the KERCADR cohort with sufficient sample size and response rate provided precise estimates for the main clinical and para-clinical NCD risk factors. These evidences need to be translated into public health interventions and monitored in the next rounds of the cohort.

  3. The Importance of Integration of Stakeholder Views in Core Outcome Set Development: Otitis Media with Effusion in Children with Cleft Palate.

    Directory of Open Access Journals (Sweden)

    Nicola L Harman

    Full Text Available Approximately 75% of children with cleft palate (CP have Otitis Media with Effusion (OME histories. Evidence for the effective management of OME in these children is lacking. The inconsistency in outcome measurement in previous studies has led to a call for the development of a Core Outcome Set (COS. Despite the increase in the number of published COS, involvement of patients in the COS development process, and methods to integrate the views of patients and health professionals, to date have been limited.A list of outcomes measured in previous research was identified through reviewing the literature. Opinion on the importance of each of these outcomes was then sought from key stakeholders: Ear, Nose and Throat (ENT surgeons, audiologists, cleft surgeons, speech and language therapists, specialist cleft nurses, psychologists, parents and children. The opinion of health professionals was sought in a three round Delphi survey where participants were asked to score each outcome using a bespoke online system. Parents and children were also asked to score outcomes in a survey and provided an in-depth insight into having OME through semi-structured interviews. The results of the Delphi survey, interviews and parent/patient survey were brought together in a final consensus meeting with representation from all stakeholders. A final set of eleven outcomes reached the definition of "consensus in" to form the recommended COS: hearing; chronic otitis media (COM; OME; receptive language skills; speech development; psycho social development; acute otitis media (AOM; cholesteatoma; side effects of treatment; listening skills; otalgia.We have produced a recommendation about the outcomes that should be measured, as a minimum, in studies of the management of OME in children with CP. The development process included input from key stakeholders and used novel methodology to integrate the opinion of healthcare professionals, parents and children.

  4. The Importance of Integration of Stakeholder Views in Core Outcome Set Development: Otitis Media with Effusion in Children with Cleft Palate

    Science.gov (United States)

    Harman, Nicola L.; Bruce, Iain A.; Kirkham, Jamie J.; Tierney, Stephanie; Callery, Peter; O'Brien, Kevin; Williamson, Paula R.

    2015-01-01

    Background Approximately 75% of children with cleft palate (CP) have Otitis Media with Effusion (OME) histories. Evidence for the effective management of OME in these children is lacking. The inconsistency in outcome measurement in previous studies has led to a call for the development of a Core Outcome Set (COS). Despite the increase in the number of published COS, involvement of patients in the COS development process, and methods to integrate the views of patients and health professionals, to date have been limited. Methods and Findings A list of outcomes measured in previous research was identified through reviewing the literature. Opinion on the importance of each of these outcomes was then sought from key stakeholders: Ear, Nose and Throat (ENT) surgeons, audiologists, cleft surgeons, speech and language therapists, specialist cleft nurses, psychologists, parents and children. The opinion of health professionals was sought in a three round Delphi survey where participants were asked to score each outcome using a bespoke online system. Parents and children were also asked to score outcomes in a survey and provided an in-depth insight into having OME through semi-structured interviews. The results of the Delphi survey, interviews and parent/patient survey were brought together in a final consensus meeting with representation from all stakeholders. A final set of eleven outcomes reached the definition of “consensus in” to form the recommended COS: hearing; chronic otitis media (COM); OME; receptive language skills; speech development; psycho social development; acute otitis media (AOM); cholesteatoma; side effects of treatment; listening skills; otalgia. Conclusions We have produced a recommendation about the outcomes that should be measured, as a minimum, in studies of the management of OME in children with CP. The development process included input from key stakeholders and used novel methodology to integrate the opinion of healthcare professionals

  5. The ICF Core Sets for hearing loss--researcher perspective. Part I: Systematic review of outcome measures identified in audiological research.

    Science.gov (United States)

    Granberg, Sarah; Dahlström, Jennie; Möller, Claes; Kähäri, Kim; Danermark, Berth

    2014-02-01

    To review the literature in order to identify outcome measures used in research on adults with hearing loss (HL) as part of the ICF Core Sets development project, and to describe study and population characteristics of the reviewed studies. A systematic review methodology was applied using multiple databases. A comprehensive search was conducted and two search pools were created, pool I and pool II. The study population included adults (≥ 18 years of age) with HL and oral language as the primary mode of communication. 122 studies were included. Outcome measures were distinguished by 'instrument type', and 10 types were identified. In total, 246 (pool I) and 122 (pool II) different measures were identified, and only approximately 20% were extracted twice or more. Most measures were related to speech recognition. Fifty-one different questionnaires were identified. Many studies used small sample sizes, and the sex of participants was not revealed in several studies. The low prevalence of identified measures reflects a lack of consensus regarding the optimal outcome measures to use in audiology. Reflections and discussions are made in relation to small sample sizes and the lack of sex differentiation/descriptions within the included articles.

  6. Pragmatic Implementation of a Stratified Primary Care Model for Low Back Pain Management in Outpatient Physical Therapy Settings: Two-Phase, Sequential Preliminary Study

    Science.gov (United States)

    George, Steven Z.

    2015-01-01

    Background The effectiveness of risk stratification for low back pain (LBP) management has not been demonstrated in outpatient physical therapy settings. Objective The purposes of this study were: (1) to assess implementation of a stratified care approach for LBP management by evaluating short-term treatment effects and (2) to determine feasibility of conducting a larger-scale study. Design This was a 2-phase, preliminary study. Methods In phase 1, clinicians were randomly assigned to receive standard (n=6) or stratified care (n=6) training. Stratified care training included 8 hours of content focusing on psychologically informed practice. Changes in LBP attitudes and beliefs were assessed using the Pain Attitudes and Beliefs Scale for Physiotherapists (PABS-PT) and the Health Care Providers Pain and Impairment Relationship Scale (HC-PAIRS). In phase 2, clinicians receiving the stratified care training were instructed to incorporate those strategies in their practice and 4-week patient outcomes were collected using a numerical pain rating scale (NPRS), and the Oswestry Disability Index (ODI). Study feasibility was assessed to identify potential barriers for completion of a larger-scale study. Results In phase 1, minimal changes were observed for PABS-PT and HC-PAIRS scores for standard care clinicians (Cohen d=0.00–0.28). Decreased biomedical (−4.5±2.5 points, d=1.08) and increased biopsychosocial (+5.5±2.0 points, d=2.86) treatment orientations were observed for stratified care clinicians, with these changes sustained 6 months later on the PABS-PT. In phase 2, patients receiving stratified care (n=67) had greater between-group improvements in NPRS (0.8 points; 95% confidence interval=0.1, 1.5; d=0.40) and ODI (8.9% points; 95% confidence interval=4.1, 13.6; d=0.76) scores compared with patients receiving standard physical therapy care (n=33). Limitations In phase 2, treatment was not randomly assigned, and therapist adherence to treatment recommendations was

  7. Pragmatic Implementation of a Stratified Primary Care Model for Low Back Pain Management in Outpatient Physical Therapy Settings: Two-Phase, Sequential Preliminary Study.

    Science.gov (United States)

    Beneciuk, Jason M; George, Steven Z

    2015-08-01

    The effectiveness of risk stratification for low back pain (LBP) management has not been demonstrated in outpatient physical therapy settings. The purposes of this study were: (1) to assess implementation of a stratified care approach for LBP management by evaluating short-term treatment effects and (2) to determine feasibility of conducting a larger-scale study. This was a 2-phase, preliminary study. In phase 1, clinicians were randomly assigned to receive standard (n=6) or stratified care (n=6) training. Stratified care training included 8 hours of content focusing on psychologically informed practice. Changes in LBP attitudes and beliefs were assessed using the Pain Attitudes and Beliefs Scale for Physiotherapists (PABS-PT) and the Health Care Providers Pain and Impairment Relationship Scale (HC-PAIRS). In phase 2, clinicians receiving the stratified care training were instructed to incorporate those strategies in their practice and 4-week patient outcomes were collected using a numerical pain rating scale (NPRS), and the Oswestry Disability Index (ODI). Study feasibility was assessed to identify potential barriers for completion of a larger-scale study. In phase 1, minimal changes were observed for PABS-PT and HC-PAIRS scores for standard care clinicians (Cohen d=0.00-0.28). Decreased biomedical (-4.5±2.5 points, d=1.08) and increased biopsychosocial (+5.5±2.0 points, d=2.86) treatment orientations were observed for stratified care clinicians, with these changes sustained 6 months later on the PABS-PT. In phase 2, patients receiving stratified care (n=67) had greater between-group improvements in NPRS (0.8 points; 95% confidence interval=0.1, 1.5; d=0.40) and ODI (8.9% points; 95% confidence interval=4.1, 13.6; d=0.76) scores compared with patients receiving standard physical therapy care (n=33). In phase 2, treatment was not randomly assigned, and therapist adherence to treatment recommendations was not monitored. This study was not adequately powered to

  8. Preliminary Assessment of the Impact on Reactor Vessel dpa Rates Due to Installation of a Proposed Low Enriched Uranium (LEU) Core in the High Flux Isotope Reactor (HFIR)

    Energy Technology Data Exchange (ETDEWEB)

    Daily, Charles R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-10-01

    An assessment of the impact on the High Flux Isotope Reactor (HFIR) reactor vessel (RV) displacements-per-atom (dpa) rates due to operations with the proposed low enriched uranium (LEU) core described by Ilas and Primm has been performed and is presented herein. The analyses documented herein support the conclusion that conversion of HFIR to low-enriched uranium (LEU) core operations using the LEU core design of Ilas and Primm will have no negative impact on HFIR RV dpa rates. Since its inception, HFIR has been operated with highly enriched uranium (HEU) cores. As part of an effort sponsored by the National Nuclear Security Administration (NNSA), conversion to LEU cores is being considered for future HFIR operations. The HFIR LEU configurations analyzed are consistent with the LEU core models used by Ilas and Primm and the HEU balance-of-plant models used by Risner and Blakeman in the latest analyses performed to support the HFIR materials surveillance program. The Risner and Blakeman analyses, as well as the studies documented herein, are the first to apply the hybrid transport methods available in the Automated Variance reduction Generator (ADVANTG) code to HFIR RV dpa rate calculations. These calculations have been performed on the Oak Ridge National Laboratory (ORNL) Institutional Cluster (OIC) with version 1.60 of the Monte Carlo N-Particle 5 (MCNP5) computer code.

  9. Hydroflotation magnetic-aided endolumenal navigation-preliminary platform in ex-vivo setting for the next paradigm in minimally invasive urologic surgery.

    Science.gov (United States)

    Kommu, Sashi S

    2010-07-01

    Navigation of endolumenal devices, such as image rendering capsules, have been described for diagnostic purposes in the animal, and more recently, human models. In urology, the ureter is a prime lumenal structure that often needs to be explored for diagnostic and therapeutic purposes. A novel device using a flotation mechanism in a water-filled environment was developed and its navigation achieved with magnetic-aided guidance. The device was tested for propulsion and real-time control in the ex-vivo setting. An endolumenal bionic worm (EBW) with a magnetic core was developed and introduced into synthetic lumens (SL) and supermarket chicken lumenal structures. The latter involved the gastrointestinal lumenal tissue of supermarket chickens; ie, the ex-vivo equivalent of a ureteral substitute lumen (USL). Navigation was graded by achievement of the EBW in propulsion to premarked sites, ability to remain static when necessary, and trauma to the USL. The structures were observed under the microscope for breech after the exercises. Navigation was observed in 10 SLs and 10 USLs. The EBW was successfully steered using the magnetic guidance system with hydroflotation. Observation of endolumenal surfaces did not reveal evidence of trauma in either model. Hydroflotation magnetic-aided endolumenal navigation (HMAEN) of a microdevice was achieved endolumenally with targeted real-time control and with no observed trauma to the structures. HMAEN could potentially be used to guide devices like the EBW to permit diagnostic and therapeutic ureteroscopy including biopsy of ureteral and renal pelvis lesions, thus ushering in the platform for the next paradigm in endolumenal urologic procedures.

  10. Therapeutic strategies evaluated by the European Society of Cutaneous Lupus Erythematosus (EUSCLE) Core Set Questionnaire in more than 1000 patients with cutaneous lupus erythematosus.

    Science.gov (United States)

    Sigges, Johanna; Biazar, Cyrus; Landmann, Aysche; Ruland, Vincent; Patsinakidis, Nikolaos; Amler, Susanne; Bonsmann, Gisela; Kuhn, Annegret

    2013-05-01

    The aim of this prospective, cross-sectional, multicentre study performed by the European Society of Cutaneous Lupus Erythematosus (EUSCLE) was to investigate different therapeutic strategies and their efficacies in cutaneous lupus erythematosus (CLE) throughout Europe. Using the EUSCLE Core Set Questionnaire, topical and systemic treatment options were analysed in a total of 1002 patients (768 females and 234 males) with different CLE subtypes. The data were correlated with the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) and the criteria of the American College of Rheumatology (ACR) for the classification of systemic lupus erythematosus. Sunscreens were applied by 84.0% of the study cohort and showed a high efficacy in preventing skin lesions in all disease subtypes, correlating with a lower CLASI activity score. Topical steroids were used in 81.5% of the patients, with an efficacy of 88.4%, whereas calcineurin inhibitors were applied in 16.4% of the study population and showed an efficacy of 61.7%. Systemic agents including antimalarials and several immunomodulating/-suppressive drugs, such as systemic steroids and methotrexate, were applied in 84.4% of the 1002 patients. The CLASI activity and damage score was higher in treated CLE patients compared to untreated patients, regardless of therapy with topical or systemic agents. In summary, preventive and therapeutic strategies of 1002 patients with different subtypes of CLE were analysed in this prospective, multicentre, Europe-wide study. Sunscreens were confirmed to be successful as preventive agents, and topical steroids showed a high efficacy, whereas antimalarials were used as first-line systemic treatment.

  11. Silencing BMI1 eliminates tumor formation of pediatric glioma CD133+ cells not by affecting known targets but by down-regulating a novel set of core genes.

    Science.gov (United States)

    Baxter, Patricia A; Lin, Qi; Mao, Hua; Kogiso, Mari; Zhao, Xiumei; Liu, Zhigang; Huang, Yulun; Voicu, Horatiu; Gurusiddappa, Sivashankarappa; Su, Jack M; Adesina, Adekunle M; Perlaky, Laszlo; Dauser, Robert C; Leung, Hon-chiu Eastwood; Muraszko, Karin M; Heth, Jason A; Fan, Xing; Lau, Ching C; Man, Tsz-Kwong; Chintagumpala, Murali; Li, Xiao-Nan

    2014-01-01

    Clinical outcome of children with malignant glioma remains dismal. Here, we examined the role of over-expressed BMI1, a regulator of stem cell self-renewal, in sustaining tumor formation in pediatric glioma stem cells. Our investigation revealed BMI1 over-expression in 29 of 54 (53.7%) pediatric gliomas, 8 of 8 (100%) patient derived orthotopic xenograft (PDOX) mouse models, and in both CD133+ and CD133- glioma cells. We demonstrated that lentiviral-shRNA mediated silencing of suppressed cell proliferation in vitro in cells derived from 3 independent PDOX models and eliminated tumor-forming capacity of CD133+ and CD133- cells derived from 2 PDOX models in mouse brains. Gene expression profiling showed that most of the molecular targets of BMI1 ablation in CD133+ cells were different from that in CD133- cells. Importantly, we found that silencing BMI1 in CD133+ cells derived from 3 PDOX models did not affect most of the known genes previously associated with the activated BMI1, but modulated a novel set of core genes, including RPS6KA2, ALDH3A2, FMFB, DTL, API5, EIF4G2, KIF5c, LOC650152, C20ORF121, LOC203547, LOC653308, and LOC642489, to mediate the elimination of tumor formation. In summary, we identified the over-expressed BMI1 as a promising therapeutic target for glioma stem cells, and suggest that the signaling pathways associated with activated BMI1 in promoting tumor growth may be different from those induced by silencing BMI1 in blocking tumor formation. These findings highlighted the importance of careful re-analysis of the affected genes following the inhibition of abnormally activated oncogenic pathways to identify determinants that can potentially predict therapeutic efficacy.

  12. The "Comprehensive ICF Core Set for Head and Neck Cancer": a Delphi consensus survey among German speaking speech and language therapists.

    Science.gov (United States)

    Engelbarts, Matthias; Schuster, Vanessa; Kisser, Ulrich; Sabariego, Carla; Stier-Jarmer, Marita; Coenen, Michaela; Ernst, Benjamin Philipp; Strieth, Sebastian; Harréus, Ulrich; Becker, Sven

    2017-02-24

    The "Comprehensive ICF Core Set for Head and Neck Cancer" (ICF-HNC) is an application of the "International Classification of Functioning, Disability and Health" (ICF), representing the characteristic spectrum of issues in patients with head and neck cancer (HNC). Our primary aim was to evaluate which categories of the ICF-HNC are dealt with by speech and language therapists (SLTs) in Germany, Austria, and Switzerland. The secondary aim was to identify outcome measures used by SLTs to measure the categories of the ICF-HNC in clinical practice. SLTs experienced in the treatment of HNC patients evaluated the categories of the ICF-HNC in a three-round Delphi survey. They were asked whether the listed categories represented issues treated by SLTs in HNC patients, and what outcome measures were used to assess them. Altogether, 31 SLTs completed the survey. 47 of 108 previously selected categories of the ICF-HNC achieved the cut-off value. Out of these, 40.4% were derived from the component "Body Functions", 36.2% from "Body Structures", 12.8% from "Environmental Factors", and 10.6% from "Activities and Participation". Altogether, 82 of the mentioned outcome measures were considered as reasonable from the perspective of SLTs. Of these, only 37 achieved more than 50% approval. This study emphasises the importance of "Body Structures" and "Body Functions" for SLTs in Germany and Switzerland in treating patients with HNC. Moreover, the results highlighted the need to agree on evidence-based outcome measures in speech and language therapy.

  13. Linking of the American Academy of Orthopaedic Surgeons Distal Radius Fracture Clinical Practice Guidelines to the International Classification of Functioning, Disability, and Health; International Classification of Diseases; and ICF Core Sets for Hand Conditions.

    Science.gov (United States)

    Esakki, Saravanan; MacDermid, Joy; Vajravelu, Saipriya

    2016-09-01

    Background: American Academy of Orthopaedic Surgeons (AAOS) distal radius fracture (DRF) clinical practice guidelines (CPG) are readily available to clinicians, patients, and policymakers. International Classification of Functioning, Disability, and Health (ICF) provides a framework for describing the impact of health conditions. The International Classification of Diseases-10th Revision (ICD-10) is a classification system to classify health conditions as specific disease or disorders. The aim of this study is to analyze and describe the scope and focus of the AAOS DRF CPG using the ICF and ICD-10 as a basis for content analysis, and to compare the content of the CPG with the ICF hand core sets as the reference standard. Methods: Established linking rules were used by 2 independent raters to analyze the 29 recommendations of the AAOS DRF CPG. ICD-10 codes were assigned in the same process. Summary linkage statistics were used to describe the results for ICF and the hand core sets. Results: Among the 29 recommendations of the AAOS DRF CPG, 5 meaningful concepts were linked to the ICF codes. Of these, 5 codes appeared on the comprehensive ICF core set and only 3 codes appeared in the brief ICF core set, and 7 conditions were covered in ICD-10 codes. Conclusions: The AAOS DRF CPG focuses on surgical interventions and has minimal linkage to the constructs of the ICD-10 and ICF. It does not address activity or participation (disability), and is not well linked to key concepts relevant to hand conditions.

  14. Improved Parallel Apriori Algorithm for Multi-cores

    Directory of Open Access Journals (Sweden)

    Swati Rustogi

    2017-04-01

    Full Text Available Apriori algorithm is one of the most popular data mining techniques, which is used for mining hidden relationship in large data. With parallelism, a large data set can be mined in less amount of time. Apart from the costly distributed systems, a computer supporting multi core environment can be used for applying parallelism. In this paper an improved Apriori algorithm for multi-core environment is proposed. The main contributions of this paper are:  An efficient Apriori algorithm that applies data parallelism in multi-core environment by reducing the time taken to count the frequency of candidate item sets.  The performance of proposed algorithm is evaluated for multiple cores on basis of speedup.  The performance of the proposed algorithm is compared with the other such parallel algorithm and it shows an improvement by more than 15% preliminary experiment

  15. Imitation (Rather than Core Language) Predicts Pragmatic Development in Young Children with ASD: A Preliminary Longitudinal Study Using CDI Parental Reports

    Science.gov (United States)

    Miniscalco, Carmela; Rudling, Maja; Råstam, Maria; Gillberg, Christopher; Johnels, Jakob Åsberg

    2014-01-01

    Background: Research in the last decades has clearly pointed to the important role of language and communicative level when trying to understand developmental trajectories in children with autism spectrum disorders (ASD). Aims: The purpose of this longitudinal study was to investigate whether (1) "core language skills", measured as…

  16. Design and development of small and medium integral reactor core

    Energy Technology Data Exchange (ETDEWEB)

    Zee, Sung Quun; Chang, M. H.; Lee, C. C.; Song, J. S.; Cho, B. O.; Kim, K. Y.; Kim, S. J.; Park, S. Y.; Lee, K. B.; Lee, C. H.; Chun, T. H.; Oh, D. S.; In, W. K.; Kim, H. K.; Lee, C. B.; Kang, H. S.; Song, K. N.

    1997-07-01

    Recently, the role of small and medium size integral reactors is remarkable in the heat applications rather than the electrical generations. Such a range of possible applications requires extensive used of inherent safety features and passive safety systems. It also requires ultra-longer cycle operations for better plant economy. Innovative and evolutionary designs such as boron-free operations and related reactor control methods that are necessary for simple reactor system design are demanded for the small and medium reactor (SMR) design, which are harder for engineers to implement in the current large size nuclear power plants. The goals of this study are to establish preliminary design criteria, to perform the preliminary conceptual design and to develop core specific technology for the core design and analysis for System-integrated Modular Advanced ReacTor (SMART) of 330 MWt power. Based on the design criteria of the commercial PWR`s, preliminary design criteria will be set up. Preliminary core design concept is going to be developed for the ultra-longer cycle and boron-free operation and core analysis code system is constructed for SMART. (author). 100 refs., 40 tabs., 92 figs.

  17. Investigation of cored bricks matrix preliminary design and thermal analysis for high temperature wind tunnel storage heater%高温风洞蓄热式加热器蓄热单元初步设计与分析

    Institute of Scientific and Technical Information of China (English)

    罗飞腾; 宋文艳; 刘伟雄; 李建平

    2013-01-01

    The storage heater is the one of heating methods for current high temperature clean air wind-tunnel application. Aiming at cored bricks storage heater, the preliminary design procedure of cored bricks matrix was investigated, including thermal performance analysis, pressure-drop and thermal stress evaluation. Combined with a typical wind-tunnel test condition, a cored bricks matrix was preliminarily designed and analyzed in detail. Especially the effects of geometric parameters on thermal performance, pressure-drop and thermal stress resistance were evaluated. The evaluation results indicate that the hole diameter and spacing are the most important design parameters dominating the other geometric parameters, heater working performance and security. The matrix height is a key designed parameter to stabilize the outlet air temperature and test duration. The preliminary design concept of cored bricks matrix was finally selected in consideration of tradeoff, which suggested that the expected Mach 6. 0 flight conditions can be well simulated by the designed cored bricks matrix of storage heater. The present research efforts could provide well reference for conceptual design and scheme evaluation of the cored bricks storage heater.%蓄热式加热器是目前高温纯净空气风洞最具潜力和优势的一种加热方式.针对空心砖型蓄热式加热器,开展了空心砖型蓄热单元初步设计研究,涉及换热性能、压降控制和热应力评估等方面.结合一个预定的试验状态要求,对空心砖型蓄热单元的初步设计进行分析与讨论,评估孔径、孔间距、蓄热阵高度等几何设计参数对换热性能、压降控制和当地热应力水平的影响,进而确定空心砖型蓄热单元的基本设计方案,结果表明孔径、孔间距是加热器设计的关键参数,对其它参数、运行性能、安全性具有显著影响,高度选择直接影响出口气流温度水平及其稳定时间,初

  18. Preliminary Results of Stress Measurement Using Drill Cores of TCDP Hole-A: an Application of Anelastic Strain Recovery Method to Three-Dimensional In-Situ Stress Determination

    Directory of Open Access Journals (Sweden)

    Weiren Lin En-Chao Yeh1

    2007-01-01

    Full Text Available In order to understand the feature of rock stress change at different depths above, within, and beneath the Chelungpu fault after the Chi-Chi earthquake, we employed a core-based stress measurement method, anelastic strain recovery (ASR technique to determine both the orientations and magnitudes of present three-dimensional principal rock stresses using drill core samples retrieved from Taiwan Chelungpu-fault Drilling Project (TCDP main Hole-A. The core samples used were taken from three depths; and their lithology were sandstone at depths of 592 and 1755 m and siltstone at 1112 m. The anelastic strains of the specimens in nine directions, including six independent directions, were measured after its in-situ stress was released. Acquired anelastic strains were of high quality and reached several hundred microstrains, which is sufficiently high for the accuracy of the measurement system used. Thus, the strain data could be used for three dimensional analysis resulting in the determination of orientations and the estimation of magnitudes of the principal in-situ stresses. Preliminary stress measurement results showed that the orientations of principal stresses changed between the shallower depth above the fault and the deeper depth beneath it, that is, the present stress distribution in the TCDP hole might be influenced by the Chelungpu fault rupture. At the same time, anelastic strain recovery measurement is well suited for the task of directly determining the orientations of principal in-situ stresses and to estimate the magnitude of stresses at large/great depth.

  19. Preliminary Assessment of the Possible BWR Core/Vessel Damage States for Fukushima Daiichi Station Blackout Scenarios Using RELAP/SCDAPSIM

    Directory of Open Access Journals (Sweden)

    C. M. Allison

    2012-01-01

    Full Text Available Immediately after the accident at Fukushima Daiichi, Innovative Systems Software and other members of the international SCDAP Development and Training Program started an assessment of the possible core/vessel damage states of the Fukushima Daiichi Units 1–3. The assessment included a brief review of relevant severe accident experiments and a series of detailed calculations using RELAP/SCDAPSIM. The calculations used a detailed RELAP/SCDAPSIM model of the Laguna Verde BWR vessel and related reactor cooling systems. The Laguna Verde models were provided by the Comision Nacional de Seguridad Nuclear y Salvaguardias, the Mexican nuclear regulatory authority. The initial assessment was originally presented to the International Atomic Energy Agency on March 21 to support their emergency response team and later to our Japanese members to support their Fukushima Daiichi specific analysis and model development.

  20. Analysis of vanillic acid in polar ice cores as a biomass burning proxy - preliminary results from the Akademii Nauk Ice Cap in Siberia

    Science.gov (United States)

    Grieman, M. M.; Jimenez, R.; McConnell, J. R.; Fritzsche, D.; Saltzman, E. S.

    2013-12-01

    Biomass burning influences global climate change and the composition of the atmosphere. The drivers, effects, and climate feedbacks related to fire are poorly understood. Many different proxies have been used to reconstruct past fire frequency from lake sediments and polar ice cores. Reconstruction of historical trends in biomass burning is challenging because of regional variability and the qualitative nature of various proxies. Vanillic acid (4-hydroxy-3-methoxybenzoic acid) is a product of the combustion of conifer lignin that is known to occur in biomass burning aerosols. Biomass burning is likely the only significant source of vanillic acid in polar ice. In this study we describe an analytical method for quantifying vanillic acid in polar ice using HPLC with electrospray ionization and tandem mass spectrometric detection. The method has a detection limit of 100 pM and a precision of × 10% at the 100 pM level for analysis of 100 μl of ice melt water. The method was used to analyze more than 1000 discrete samples from the Akademii Nauk ice cap on Severnaya Zemlya in the high Russia Arctic (79°30'N, 97°45'E) (Fritzsche et al., 2002; Fritzsche et al., 2005; Weiler et al., 2005). The samples range in age over the past 2,000 years. The results show a mean vanillic acid concentration of 440 × 710 pM (1σ), with elevated levels during the periods from 300-600 and 1450-1550 C.E.

  1. Mid-twentieth century increases in anthropogenic Pb, Cd and Cu in central Asia set in hemispheric perspective using Tien Shan ice core

    Science.gov (United States)

    Grigholm, B.; Mayewski, P. A.; Aizen, V.; Kreutz, K.; Wake, C. P.; Aizen, E.; Kang, S.; Maasch, K. A.; Handley, M. J.; Sneed, S. B.

    2016-04-01

    High-resolution major and trace element (Al, As, Ca, Cd, Co, Cr, Cu, Fe, Li, Mn, Na, Pb, S, Ti, and V) ice core records from Inilchek glacier (5120 m above sea level) on the northwestern margin of the Tibetan Plateau provide the first multi-decadal ice core record spanning the period 1908-1995 AD in central Tien Shan. The trace element records reveal pronounced temporal baseline trends and concentration maxima characteristic of post-1950 anthropogenic emissions. Examination of Pb, Cd and Cu concentrations, along with non-crustal calculation estimates (i.e. excess (ex) and enrichment factor (EF)), reveal that discernable anthropogenic inputs began during the 1950s and rapidly increased to the late-1970s and early 1980s, by factors up to of 5, 6 and 3, respectively, relative to a 1910-1950 means. Pb, Cd and Cu concentrations between the 1950s-1980s are reflective of large-scale Soviet industrial and agricultural development, including the growth of production and/or consumption of the non-ferrous metals, coal and phosphate fertilizers. NOAA HYSPLIT back-trajectory frequency analysis suggests pollutant sources originating primarily from southern Kazakhstan (e.g. Shymkent and Balkhash) and the Fergana Valley (located in Kazakhstan, Uzbekistan and Kyrgyzstan). Inilchek ice core Pb, Cd and Cu reveals declines during the 1980s concurrent with Soviet economic declines, however, due to the rapid industrial and agricultural growth of western China, Pb, Cd and Cu trends increase during the 1990s reflecting a transition from primarily central Asian sources to emission sources from western China (e.g. Xinjiang Province).

  2. A comparison of embedded total task instruction in teaching behavioral chains to massed one-on-one instruction for students with intellectual disabilities: accessing general education settings and core academic content.

    Science.gov (United States)

    Jameson, J Matt; Walker, Ryan; Utley, Kristen; Maughan, Ryan

    2012-05-01

    This study is a comparison of the embedded instruction of behavioral chains with more traditional (one-on-one massed trials in special education setting) instructional procedures for teaching behavioral chains to students with significant cognitive disabilities. Although embedded instruction has emerged as a promising potential instructional procedure, no literature has examined the efficacy of embedded instructional procedures to teach more complex chained behaviors. To date, all research on embedding instruction in general education settings has focused on teaching discrete skills. This study compares instruction of embedded total task chains with more traditional (one-on-one massed trials in special education setting) instructional procedures for teaching behavioral chains. The chains targeted for instruction were selected by state core educational needs and functional skill development.

  3. The Psychotherapy Process with Adolescents: A First Pilot Study and Preliminary Comparisons between Different Therapeutic Modalities Using the "Adolescent Psychotherapy Q-Set"

    Science.gov (United States)

    Bychkova, Tetyana; Hillman, Saul; Midgley, Nick; Schneider, Celeste

    2011-01-01

    An innovative methodology is presented for describing the therapeutic processes involved in five types of adolescent treatments: psychoanalysis, psychodynamic psychotherapy, cognitive-behavioural therapy, mentalisation-based treatment and interpersonal psychotherapy. Using the "Adolescent Psychotherapy Q-Set" (APQ), 18 experienced clinicians…

  4. Language Contact and Language Conflict in Autochthonous Language Minority Settings in the EU: A Preliminary Round-Up of Guiding Principles and Research Desiderata

    Science.gov (United States)

    Darquennes, Jeroen

    2010-01-01

    This contribution deals with language contact and language conflict in autochthonous language minority settings in the European Union. It rounds up a number of concepts that guide macro-socio-linguistic and macrocontact-linguistic research on language minorities. The description of these concepts results in a list of research desiderata.

  5. Development of deep-seated joint sets in the different stages of mountain building: a preliminary study in the northern fold-and-thrust belt of Taiwan

    Science.gov (United States)

    Lee, Jian-Cheng; Chu, Hao-Tsu; Angelier, Jacques; Begerat, Françoise

    2013-04-01

    Systematic joint sets are one of the most common and persistent features within a brittle deformation regime, usually found in intact rocks, such as massive sandstone. However, joint occurrence can take place under different circumstances from very shallow to rather deep crust, which raise challenges for understanding the mechanisms of its development and thus provokes debates in past decades. In this study, we characterize the deformation structures, including micro fault and joint, by comparing their geometric relation with stratigraphic bedding plane. We intend not only to differentiate the relative chronology of different structures but also to determine the chronological orders and stages during thrust stacking processes in which rocks buried to certain depths and then exhumed from depths to surface. We take the northern fold-and-thrust belt of Taiwan as our case study area. The study area is composed of Pleistocene to Oligocene, terrestrial to shallow marine sedimentary deposits, which was exhumed accompanied with a series of imbricate thrusts during the Plio-Pleistocene orogeny of arc-continent collision between the Philippine Sea and Eurasian plates. We study four cross sections from little deformed rock formations in the foreland to intense folded and even slightly metamorphosed terrains in the slate belt, in order to characterize and distinguish different brittle structures at different depths. Particular attention is paid to the development of the joint sets at different depths and their relationship with the bedding plane and other associated deformation features where joints happen to occur. We found that 1) the most predominant joint sets are deep-seated and tectonics related, in comparison with shallow released joints, although their relation with tectonic stress orientation remains inconclusive; 2) the onset depths of development of joint sets can be as shallow as 3-4 km and as deep as 10-15 km. As to whether the development occurs during burial or

  6. Research on the Criterion-related Validity of Comprehensive ICF Core Sets for Stroke%脑卒中ICF核心分类量表综合版的效标关联效度研究①

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    Objective To analyse the criterion-related validity of comprehensive ICF Core Sets for stroke. Methods Comparison of con-cepts of items among SF-36, Barthel index, Mini-mental State Examination, WHO quality of life-BREF, WHO Disability Assessment ScaleⅡ and Comprehensive ICF Core Sets for stroke had been conducted using the linking rules established by Cieza and Stucki. Field test had been conducted for 93 patients with stroke with the above 6 scales. Results 16 body function items and 27 activities and participation items matched with items of the selected functioning measurement scales (0.4core sets for stroke has good criterion-related validity.%  目的分析研究脑卒中ICF核心分类量表(ICF Core Sets)综合版的效标关联效度。方法根据联系规则将健康调查简表(SF-36量表)、Barthel指数、简易精神状态检查(MMSE)、世界卫生组织生存质量测量简表(WHOQOL-BREF)、世界卫生组织《残疾评定量表》(WHO-DASⅡ)中项目的概念与脑卒中ICF核心分类量表综合版中项目的概念作定性研究,确定测量项目内容的关联性。在此基础上选择上述6个量表对93例脑卒中患者进行临床测量研究和相关分析。结果脑卒中ICF核心分类量表综合版中16个身体功能项目及27个活动和参与项目与本研究所选择的测试量表中的项目内容相关(0.4

  7. Proteomics Core

    Data.gov (United States)

    Federal Laboratory Consortium — Proteomics Core is the central resource for mass spectrometry based proteomics within the NHLBI. The Core staff help collaborators design proteomics experiments in a...

  8. Proteomics Core

    Data.gov (United States)

    Federal Laboratory Consortium — Proteomics Core is the central resource for mass spectrometry based proteomics within the NHLBI. The Core staff help collaborators design proteomics experiments in...

  9. Iowa Core Annual Report

    Science.gov (United States)

    Iowa Department of Education, 2015

    2015-01-01

    One central component of a great school system is a clear set of expectations, or standards, that educators help all students reach. In Iowa, that effort is known as the Iowa Core. The Iowa Core represents the statewide academic standards, which describe what students should know and be able to do in math, science, English language arts, and…

  10. The impact of depression and somatic symptoms on treatment outcomes in patients with chronic prostatitis/chronic pelvic pain syndrome: a preliminary study in a naturalistic treatment setting.

    Science.gov (United States)

    Koh, J S; Ko, H J; Wang, S-M; Cho, K J; Kim, J C; Lee, S-J; Pae, C-U

    2014-04-01

    The aim of this study was to evaluate the impact of depression and somatic symptoms on treatment outcomes in Korean male patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) attending a routine clinical practice. This was a 12-week prospective observational study (n = 80). The Korean version of the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) to measure the severity of CP/CPPS, the Korean version of the Patient Health Questionnaire-9 (PHQ-9) to assess depression, the Korean version of the Patient Health Questionnaire-15 (PHQ-15) to evaluate somatisation and the Korean version of the EuroQol Questionnaire-5 Dimensions (EQ-5D), specifically the EQ-5D utility index and the EQ-5D visual analogue scale (EQ-5D VAS), to assess quality of life, were utilised and given at baseline and week 12. The primary and secondary end-points in this study were changes in the NIH-CPSI total score from baseline to week 12 according to depression and somatisation. The change in NIH-CPSI total score was significantly higher in those without depression than in those with depression (p = 0.003), with a magnitude of difference of 2.8. The responder rate (a ≥ 4 point decrease in NIH-CPSI total score from baseline) was significantly higher in those without depression (42.9%) than in those with depression (17.2%, p = 0.023). However, significant differences were not observed between the two groups in the other outcome measures or in all study outcomes between subjects with or without somatisation. A logistic regression analysis revealed that the presence or absence of depression may be a principal predictor of response to treatment. These preliminary results indicate that depression may have a negative impact on treatment outcome and is a likely predictor of response to treatment in patients with CP/CPPS. However, additional studies with adequate power and improved design are necessary to further support the present findings. © 2014

  11. Development of a 24-locus multiplex system to incorporate the core loci in the Combined DNA Index System (CODIS) and the European Standard Set (ESS).

    Science.gov (United States)

    Guo, Fei; Shen, Hongying; Tian, Huaizhou; Jin, Ping; Jiang, Xianhua

    2014-01-01

    The 24-locus multiplex system allows co-amplification and fluorescent detection of 24 loci (23 STR loci and Amelogenin), including STR loci in the Combined DNA Index System (CODIS) and the ESS (European Standard Set) as well as five additional loci (D2S1338, D6S1043, D19S433, Penta D and Penta E) commonly used in commercial kits. It facilitates data sharing and minimizes adventitious matches within national or between international DNA databases. Additionally, the system can amplify directly from blood and buccal samples spotted on filter paper and swabs and reduce the cycling time to less than one hour and a half. Primers, internal size standard, allelic ladders and matrix standard set were designed and created in-house with a design strategy to work in this multiplex. Developmental validation experiments followed the Scientific Working Group on DNA Analysis Methods (SWGDAM) and the Chinese National Standard (GA/T815-2009) guidelines. The system was evaluated by species specificity, sensitivity, stability, precision and accuracy, case-type samples, population, mixture and PCR-based studies. The results demonstrate that the 24-locus multiplex system is a robust and reliable identification assay as required for forensic DNA typing and databasing.

  12. Development and application of a set of mesh-based and age-dependent Chinese family phantoms for radiation protection dosimetry: Preliminary Data for external photon beams

    Science.gov (United States)

    Pi, Yifei; Zhang, Lian; Huo, Wanli; Feng, Mang; Chen, Zhi; Xu, X. George

    2017-09-01

    A group of mesh-based and age-dependent family phantoms for Chinese populations were developed in this study. We implemented a method for deforming original RPI-AM and RPI-AF models into phantoms of different ages: 5, 10 ,15 and adult. More than 120 organs for each model were processed to match with the values of the Chinese reference parameters within 0.5%. All of these phantoms were then converted to voxel format for Monte Carlo simulations. Dose coefficients for adult models were counted to compare with those of RPI-AM and RPI-AF. The results show that there are significant differences between absorbed doses of RPI phantoms and these of our adult phantoms at low energies. Comparisons for the dose coefficients among different ages and genders were also made. it was found that teenagers receive more radiation doses than adults under the same irradiation condition. This set of phantoms can be utilized to estimate dosimetry for Chinese population for radiation protection, medical imaging, and radiotherapy.

  13. Recommended patient-reported core set of symptoms and quality-of-life domains to measure in ovarian cancer treatment trials.

    Science.gov (United States)

    Donovan, Kristine A; Donovan, Heidi S; Cella, David; Gaines, Martha E; Penson, Richard T; Plaxe, Steven C; von Gruenigen, Vivian E; Bruner, Deborah Watkins; Reeve, Bryce B; Wenzel, Lari

    2014-07-01

    There is no consensus as to what symptoms or quality-of-life (QOL) domains should be measured as patient-reported outcomes (PROs) in ovarian cancer clinical trials. A panel of experts convened by the National Cancer Institute reviewed studies published between January 2000 and August 2011. The results were included in and combined with an expert consensus-building process to identify the most salient PROs for ovarian cancer clinical trials. We identified a set of PROs specific to ovarian cancer: abdominal pain, bloating, cramping, fear of recurrence/disease progression, indigestion, sexual dysfunction, vomiting, weight gain, and weight loss. Additional PROs identified in parallel with a group charged with identifying the most important PROs across cancer types were anorexia, cognitive problems, constipation, diarrhea, dyspnea, fatigue, nausea, neuropathy, pain, and insomnia. Physical and emotional domains were considered to be the most salient domains of QOL. Findings of the review and consensus process provide good support for use of these ovarian cancer-specific PROs in ovarian cancer clinical trials.

  14. 人工气道温度设定对极低体重儿核心体温的影响%The effects of temperature setting of artificial airway on core temperature in very low birth weight infant

    Institute of Scientific and Technical Information of China (English)

    魏春兰; 唐淑云; 凌秀红

    2014-01-01

    Objective:To study the effects of the temperature of inspiratory gas with artificial airway on core temperature in very low birth weight infants. Methods:45 very low birth weight infants with artificial airway were randomly divided into three groups according to the temperature of inspiratory gas. The temperature of inspiratory gas was 36. 5-37. 3℃ in the group A,34. 5-35℃ in the group B,and 38. 5-39℃ in the group C. The gas temperature at the side of patents′mouth as the setting temperature was dicided by the inductor. The rectal temperature of the infants were recorded every 2 hours. Results:The core temperature in the infant was maintained at neutral temperature when the setting temperature was 36. 5-37. 3℃(group A)(P<0. 05). The core tem-perature was lower than neutral temperature when the setting temperature was 34. 5-35℃(group B). The core temperature was higher than neutral temper-ature when the setting temperature was 38. 5-39 ℃(group C). Conclusion:The core temperature in very low birth weight infant with artificial airway could be maintained at neutral temperature when the temperature of inspiratory gas was 36. 5-37. 3 ℃. At the same time,It could decrease oxygen consumption, the loss of evaporative heat,metabolism,and reduce complication.%目的:探讨人工气道吸入气体温度对极低体重儿核心体温的影响。方法:将我院符合入组标准的45例建立人工气道的极低体重儿随机等分为3组,A组吸入气体温度设置为36.5~37.3℃,B组吸入气体温度设置为34.5~35℃,C组吸入气体温度设置为38.5~39℃。均以感应器测定的到达患儿口边的气体温度为设定温度,每2 h测量3组患儿体温(肛温)1次并记录。结果:A组患儿核心温度维持在中性温度,B组患儿核心温度低于中性温度,C组则高于中性温度。结论:极低体重儿建立人工气道时将吸入气体温度调到36.5~37.3℃可使极低体重儿的核心体温度维持在中性温度,同

  15. 基于多层核心集凝聚思想的视频关键帧提取%KEY VIDEO FRAME EXTRACTION BASED ON MULTILAYER CORE SET AGGLOMERATION THOUGHTS

    Institute of Scientific and Technical Information of China (English)

    杨臻; 杨志宏

    2015-01-01

    Key frame extraction is a key technology in video retrieval.Traditional key frame extraction algorithm has the problems of low accuracy and low recall and precision in video retrieval.For these problems,we proposed a key video frame extraction algorithm which is based on multilayer core agglomeration thoughts.First,we studied the multilayer core set agglomeration algorithm (MULCA)presented in literature [1 ],and utilised the characteristic of K-medoids algorithm-it uses real data as the clustering centre ! to improve two important processes of MULCA algorithm,the roughening of agglomeration and the refinement of agglomeration,we also substituted the original top layer core set derived from roughening process with it,designed a new multilayer core set agglomeration algorithm (IMULCA),and realised the fast and accurate positioning of top layer core set,which can appropriately reduce the agglomeration layer and simplify the computation complexity of the algorithm.Then,we applied the IMULCA algorithm to the extraction of key video frames.Experimental results showed that the proposed algorithm,compared with the previous algorithm,could more effectively extract the key video frame.%关键帧提取是视频检索的一项关键技术。针对传统的关键帧提取算法准确度低,视频检索的查全率和查准率不高的问题,提出一种基于多层核心凝聚思想的视频关键帧提取算法。首先,对文献[1]提出的多层核心集凝聚算法(MULCA)进行研究,并利用K-medoids算法用真实数据作为聚类中心的特性,对MULCA算法的凝聚粗化和凝聚细化两个重要过程进行改进,用其替代原粗化过程得到的顶层核心集,设计了一种新的多层核心集凝聚算法(IMULCA),实现了顶层核心集的快速准确定位,并可适当减少凝聚层数,简化了算法的计算复杂性。然后,将IMULCA算法应用到视频关键帧提取中,实验结果表明所提改进算法相对于

  16. A systematic review of the utility of the International Classification of Functioning, Disability and Health core sets for patients with dysphagia%基于系统回顾法的吞咽障碍ICF核心类目研究

    Institute of Scientific and Technical Information of China (English)

    喻勇; 姜丽; 窦祖林; 卫小梅

    2016-01-01

    目的 筛选吞咽障碍患者“国际功能、残疾和健康分类”(ICF)核心类目.方法 采用系统回顾研究法,从EMBASE、Medline及CNKI中检索筛选出常用的吞咽障碍评定量表,将量表评估项目纳人ICF框架内,与ICF类目相匹配,最终筛选出吞咽障碍患者ICF核心类目.结果 共纳入60篇与吞咽障碍有关的临床随机对照研究,筛选出功能性经口进食(FOIS)、Rosenbek误吸程度分级(RASL)、进食评估工具(EAT-10)、饮水试验、吞咽障碍生活质量和照顾质量量表(SWAL-QQL-CARE)、吞咽造影检查评估量表(VFSFS)共6个常用吞咽障碍评定量表,吞咽障碍ICF核心类目57项,其中身体功能27项、身体结构13项、活动和参与7项、环境因素10项.结论 采用系统回顾研究法初步筛选出了吞咽障碍的ICF核心类目,有望为吞咽障碍的评估、治疗提供更全面的框架.%Objective To identify International Classification of Functioning,Disability and Health (ICF) core categories most applicable to patients with dysphagia.Methods Swallowing dysfunction rating scales were searched through Embase,MEDLINE and CNKI covering the period between August 2005 and August 2015.All the scales found were classified and matched with different dimensions of the ICF so as to select the most applicable core sets.Results A total of 57 ICF items were included in the core set designed for dysphagia,including 27 body function items,13 body structure items,7 activity and participation items and 10 environmental factor items.Conclusions The ICF core categories selected for dysphagia through this systematic review provide a more comprehensive framework for future assessment and treatment of dysphagia.

  17. Ice cores

    DEFF Research Database (Denmark)

    Svensson, Anders

    2014-01-01

    Ice cores from Antarctica, from Greenland, and from a number of smaller glaciers around the world yield a wealth of information on past climates and environments. Ice cores offer unique records on past temperatures, atmospheric composition (including greenhouse gases), volcanism, solar activity......, dustiness, and biomass burning, among others. In Antarctica, ice cores extend back more than 800,000 years before present (Jouzel et al. 2007), whereas. Greenland ice cores cover the last 130,000 years...

  18. Ice cores

    DEFF Research Database (Denmark)

    Svensson, Anders

    2014-01-01

    Ice cores from Antarctica, from Greenland, and from a number of smaller glaciers around the world yield a wealth of information on past climates and environments. Ice cores offer unique records on past temperatures, atmospheric composition (including greenhouse gases), volcanism, solar activity......, dustiness, and biomass burning, among others. In Antarctica, ice cores extend back more than 800,000 years before present (Jouzel et al. 2007), whereas. Greenland ice cores cover the last 130,000 years...

  19. 75 FR 52596 - Financial Education Core Competencies; Comment Request

    Science.gov (United States)

    2010-08-26

    ... Financial Education Core Competencies; Comment Request AGENCY: Department of the Treasury. ACTION: Notice... proposed set of financial education core competencies (``Core Competencies''). Comments are requested specifically on whether the list of Core Competencies referenced in the Supplementary Section is complete...

  20. An Expansion Algorithm Based on the Rule Core Value of the Rough Sets Theory%一种基于粗糙集理论的规则核值的扩展算法

    Institute of Scientific and Technical Information of China (English)

    肖志军; 蒙峭缘; 陈寿辉

    2014-01-01

    应用粗糙集的理论,提出一种基于规则核值的扩展算法。利用该算法对从信息数据进行约简,并求出规则的核值。在规则核值的基础上对规则进行扩展,从而去除规则中的冗余条件,得到更加简化的规则。%According to the rough set the theory, expansion algorithm method based on the rule core value is proposed, using this algorithm elimination rule in redundant attribute value, thus obtaining even more simplified rules.

  1. Validez de apariencia y concurrente de un instrumento de evaluación de la discapacidad en personas con lesión medular crónica, basado en el core set abreviado de la cif

    OpenAIRE

    2013-01-01

    Objetivo. Determinar la validez de apariencia y concurrente de un instrumento de evaluación de la discapacidad en personas con lesión medular crónica (SCI-DAS), basado en el core set abreviadode la CIF. Metodología. Participaron 100 personas con lesión medular de más de seis meses de evolución de cuatro ciudades colombianas, así como ocho fisioterapeutas con una experiencia profesional promedio de 6,75 años. La validez de apariencia se evaluó a través de un grupo focal y una encuesta a los ob...

  2. A new set-up for simultaneous high-precision measurements of CO2, δ13C-CO2 and δ18O-CO2 on small ice core samples

    Science.gov (United States)

    Jenk, Theo Manuel; Rubino, Mauro; Etheridge, David; Ciobanu, Viorela Gabriela; Blunier, Thomas

    2016-08-01

    Palaeoatmospheric records of carbon dioxide and its stable carbon isotope composition (δ13C) obtained from polar ice cores provide important constraints on the natural variability of the carbon cycle. However, the measurements are both analytically challenging and time-consuming; thus only data exist from a limited number of sampling sites and time periods. Additional analytical resources with high analytical precision and throughput are thus desirable to extend the existing datasets. Moreover, consistent measurements derived by independent laboratories and a variety of analytical systems help to further increase confidence in the global CO2 palaeo-reconstructions. Here, we describe our new set-up for simultaneous measurements of atmospheric CO2 mixing ratios and atmospheric δ13C and δ18O-CO2 in air extracted from ice core samples. The centrepiece of the system is a newly designed needle cracker for the mechanical release of air entrapped in ice core samples of 8-13 g operated at -45 °C. The small sample size allows for high resolution and replicate sampling schemes. In our method, CO2 is cryogenically and chromatographically separated from the bulk air and its isotopic composition subsequently determined by continuous flow isotope ratio mass spectrometry (IRMS). In combination with thermal conductivity measurement of the bulk air, the CO2 mixing ratio is calculated. The analytical precision determined from standard air sample measurements over ice is ±1.9 ppm for CO2 and ±0.09 ‰ for δ13C. In a laboratory intercomparison study with CSIRO (Aspendale, Australia), good agreement between CO2 and δ13C results is found for Law Dome ice core samples. Replicate analysis of these samples resulted in a pooled standard deviation of 2.0 ppm for CO2 and 0.11 ‰ for δ13C. These numbers are good, though they are rather conservative estimates of the overall analytical precision achieved for single ice sample measurements. Facilitated by the small sample requirement

  3. Transformer core

    NARCIS (Netherlands)

    Mehendale, A.; Hagedoorn, Wouter; Lötters, Joost Conrad

    2010-01-01

    A transformer core includes a stack of a plurality of planar core plates of a magnetically permeable material, which plates each consist of a first and a second sub-part that together enclose at least one opening. The sub-parts can be fitted together via contact faces that are located on either side

  4. Transformer core

    NARCIS (Netherlands)

    Mehendale, A.; Hagedoorn, Wouter; Lötters, Joost Conrad

    2008-01-01

    A transformer core includes a stack of a plurality of planar core plates of a magnetically permeable material, which plates each consist of a first and a second sub-part that together enclose at least one opening. The sub-parts can be fitted together via contact faces that are located on either side

  5. IGBT accelerated aging data set.

    Data.gov (United States)

    National Aeronautics and Space Administration — Preliminary data from thermal overstress accelerated aging using the aging and characterization system. The data set contains aging data from 6 devices, one device...

  6. Information Update Research Fellowship for International Young Scientists NSFC Announced Results of Preliminary Evaluation of Bilateral Cooperative Research Projects With Danish National Research Foundation NSFC Announced Results of Preliminary Evaluation of Bilateral Cooperative Research Projects with DFG News in Brief: NSFC set up Department of Medical Sciences NSFC Announced Approved Cooperative Projects With France and Germany NSFC Announced Results of Preliminary Evaluation of Bilateral Cooperative Research Projects With Academy of Finland NSFC Announced Application Guide for Cooperative Research Projects with K. T. Li Foundation NSFC Announced Results of Preliminary Evaluation of Bilateral Cooperative Research projects With Japan Science and Technology Agency NSFC Announced Application Guide for Cooperative Research Projects With Royal Society of Edinburgh for 2010 NSFC Announced a List of proved Cooperative Projects With Three International Organizations

    Science.gov (United States)

    2009-01-01

    Research Fellowship for International Young Scientists NSFC Announced Results of Preliminary Evaluation of Bilateral Cooperative Research Projects With Danish National Research Foundation NSFC Announced Results of Preliminary Evaluation of Bilateral Cooperative Research Projects with DFG News in Brief: NSFC set up Department of Medical Sciences NSFC Announced Approved Cooperative Projects With France and Germany NSFC Announced Results of Preliminary Evaluation of Bilateral Cooperative Research Projects With Academy of Finland NSFC Announced Application Guide for Cooperative Research Projects with K. T. Li Foundation NSFC Announced Results of Preliminary Evaluation of Bilateral Cooperative Research projects With Japan Science and Technology Agency NSFC Announced Application Guide for Cooperative Research Projects With Royal Society of Edinburgh for 2010 NSFC Announced a List of proved Cooperative Projects With Three International Organizations

  7. The ICF core sets for hearing loss project: International expert survey on functioning and disability of adults with hearing loss using the international classification of functioning, disability, and health (ICF).

    Science.gov (United States)

    Granberg, Sarah; Swanepoel, De Wet; Englund, Ulrika; Möller, Claes; Danermark, Berth

    2014-08-01

    To identify relevant aspects of functioning, disability, and contextual factors for adults with hearing loss (HL) from hearing health professional perspective summarized using the ICF classification as reference tool. Internet-based cross-sectional survey using open-ended questions. Responses were analysed using a simplified content analysis approach to link concept to ICF categories according to linking rules. Hearing health professionals (experts) recruited through e-mail distribution lists of professional organizations and personal networks of ICF core set for hearing loss steering committee members. Stratified sampling according to profession and world region enhanced the international and professional representation. Sixty-three experts constituted the stratified sample used in the analysis. A total of 1726 meaningful concepts were identified in this study, resulting in 209 distinctive ICF categories, with 106 mentioned by 5% or more of respondents. Most categories in the activities & participation component related to communication, while the most frequent environmental factors related to the physical environment such as hearing aids or noise. Mental functions, such as confidence or emotional functions were also frequently highlighted. More than half (53.3%) of the entire ICF classification categories were included in the expert survey results. This emphasizes the importance of a multidimensional tool, such as the ICF, for assessing persons with hearing loss.

  8. Ice Cores

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Records of past temperature, precipitation, atmospheric trace gases, and other aspects of climate and environment derived from ice cores drilled on glaciers and ice...

  9. Core BPEL

    DEFF Research Database (Denmark)

    Hallwyl, Tim; Højsgaard, Espen

    extensions. Combined with the fact that the language definition does not provide a formal semantics, it is an arduous task to work formally with the language (e.g. to give an implementation). In this paper we identify a core subset of the language, called Core BPEL, which has fewer and simpler constructs......, does not allow omissions, and does not contain ignorable elements. We do so by identifying syntactic sugar, including default values, and ignorable elements in WS-BPEL. The analysis results in a translation from the full language to the core subset. Thus, we reduce the effort needed for working...... formally with WS-BPEL, as one, without loss of generality, need only consider the much simpler Core BPEL. This report may also be viewed as an addendum to the WS-BPEL standard specification, which clarifies the WS-BPEL syntax and presents the essential elements of the language in a more concise way...

  10. Core BPEL

    DEFF Research Database (Denmark)

    Hallwyl, Tim; Højsgaard, Espen

    extensions. Combined with the fact that the language definition does not provide a formal semantics, it is an arduous task to work formally with the language (e.g. to give an implementation). In this paper we identify a core subset of the language, called Core BPEL, which has fewer and simpler constructs......, does not allow omissions, and does not contain ignorable elements. We do so by identifying syntactic sugar, including default values, and ignorable elements in WS-BPEL. The analysis results in a translation from the full language to the core subset. Thus, we reduce the effort needed for working...... formally with WS-BPEL, as one, without loss of generality, need only consider the much simpler Core BPEL. This report may also be viewed as an addendum to the WS-BPEL standard specification, which clarifies the WS-BPEL syntax and presents the essential elements of the language in a more concise way...

  11. Core benefits

    National Research Council Canada - National Science Library

    Keith, Brian W

    2010-01-01

    This SPEC Kit explores the core employment benefits of retirement, and life, health, and other insurance -benefits that are typically decided by the parent institution and often have significant governmental regulation...

  12. Compliance to The Joint Commission proposed Core Measure set on osteoporosis-associated fracture: review of different secondary fracture prevention programs in an open medical system from 2010 to 2015.

    Science.gov (United States)

    Fojas, Ma Conchitina; Southerland, Lauren T; Phieffer, Laura S; Stephens, Julie A; Srivastava, Tanya; Ing, Steven W

    2017-12-01

    There are care gaps in the evaluation and treatment of osteoporosis after a fragility fracture. The Joint Commission is considering adoption of core measures. We compared compliance between two secondary fracture prevention programs in our institution. Incorporating strengths of both may provide the best outcomes for secondary fracture prevention. There are significant care gaps in the evaluation and treatment of osteoporosis after occurrence of fragility fracture. The Joint Commission is considering adoption of a core measure set on osteoporosis-associated fractures, including laboratory assessment, bone density testing, and osteoporosis pharmacologic therapy. We compared compliance to these proposed measures between two secondary fracture prevention programs in patients hospitalized for acute fracture in an open medical system. We conducted a retrospective, single center medical records review of a nurse practitioner-led Fracture Liaison Service (FLS), a physician-led Fracture Prevention Program (FPP), and a historical time without any secondary fracture prevention program (Usual Care) for baseline care. Primary outcomes were the completion of five laboratory tests (calcium, 25-hydroxy vitamin D, renal function, liver function, and complete blood count), order placement and completion of dual x-ray absorptiometry (DXA) scan within 3 months, prescription of osteoporosis medication within 3 months, and medication adherence at 6 months after hospital discharge. Completion of all five laboratory tests was higher in FPP versus FLS (84.7 vs. 36.9%, p < 0.001). DXA scan completion was higher in FPP than FLS but not statistically significant (66.7 vs. 54.9%, p = 0.11). Medication prescription at 3 months and adherence at 6 months were significantly higher in FPP versus FLS (65.3 vs. 24.0%, p < 0.001 and 70.8 vs. 27.7%, p < 0.001, respectively). Incorporating strengths of both FLS (care coordination) and FPP (physician direction) may provide the best outcomes

  13. JWST NIRCam WFSS Ice Feature Spectroscopy in Nearby Molecular Cores

    Science.gov (United States)

    Chu, Laurie; Hodapp, Klaus W.; Rieke, Marcia J.; Meyer, Michael; Greene, Thomas P.; JWST NIRCam Science Team

    2017-06-01

    In molecular clouds above a few magnitudes of total visual extinction, some components of the molecular gas freeze out on the surfaces of dust grains. These ice mantles around dust grains are the site of complex surface chemistry that leads to the formation of simple organic molecules in these mantles. The icy surfaces also facilitate the coaggulation of the dust particles, setting the stage for grain growth and ultimately the formation of planetary bodies.As part of the JWST NIRCam GTO program, we plan to observe a selection of small molecular cores using the wide field grism spectroscopy mode of NIRCam.This poster presents the results of a preliminary study of several candidate molecular cores using UKIRT, Spitzer IRAC, IRTF SpeX, Keck MOSFIRE and Subaru MOIRCS data.After the prelimary studies we have selected three molecular cores in different evolutionary stages for the GTO program: B68, a quiescent molecular core, LDN 694-2, a collapsing pre-stellar core, and B335, a protostellar core. All these cores are seen against a dense background of stars in the inner Galaxy and offer the opportunity for spatially well resolved mapping of the ice feature distribution. We will obtain slitless grism spectroscopy in six filters covering the features of H2O, CO2, CO, CH3OH, and the XCN feature. Simulations using aXeSIM have shown that spectrum overlap will occur in a fraction of the spectra, but will not be a prohibitive problem.Our poster will discuss the details of observations planned out in the APT system.

  14. A study on the recriticality possibilities of fast reactor cores after a hypothetical core meltdown accident

    Energy Technology Data Exchange (ETDEWEB)

    Na, Byung Chan; Han, Do Hee; Kim, Young Cheol

    1997-04-01

    The preliminary and parametric sensitivity study on recriticality risk of fast reactor cores after a hypothetical total core meltdown accident was performed. Only the neutronic aspects of the accident was considered for this study, independent of the accident scenario. Estimation was made for the quantities of molten fuel which must be ejected out of the core in order to assure a sub-critical state. Diverse parameters were examined: molten pool type (homogenized or stratified), fuel temperature, conditions of the reactor core, core size (small or large), and fuel type (oxide, nitride, metal) (author). 7 refs.

  15. Fiber-Reinforced-Foam (FRF) Core Composite Sandwich Panel Concept for Advanced Composites Technologi

    Science.gov (United States)

    2010-01-01

    Fiber-Reinforced-Foam (FRF) Core Composite Sandwich Panel Concept for Advanced Composites Technologies Project - Preliminary Manufacturing Demonstration Articles for Ares V Payload Shroud Barrel Acreage Structure

  16. Preliminary Study of Gas Cooled Fast Breeder Reactor with Heterogen Percentage of Uranium–Plutonium Carbide based fuel and 300 MWt Power

    Science.gov (United States)

    Clief Pattipawaej, Sandro; Su’ud, Zaki

    2017-01-01

    A preliminary design study of GFR with helium gas-cooled has been performed. In this study used natural uranium and plutonium results LWR waste as fuel. Fuel with a small percentage of plutonium are arranged on the inside of the core area, and the fuel with a greater percentage set on the outside of the core area. The configuration of such fuel is deliberately set to increase breeding in this part of the central core and reduce the leakage of neutrons on the outer side of the core, in order to get long-lived reactor with a small reactivity. Configuration of fuel as it is also useful to generate a peak power reactors with relatively low in both the direction of axial or radial. Optimization has been done to fuel fraction 45.0% was found that the reactor may be operating in more than 10 year time with excess reactivity less than 1%.

  17. A Preliminary Jupiter Model

    CERN Document Server

    Hubbard, W B

    2016-01-01

    In anticipation of new observational results for Jupiter's axial moment of inertia and gravitational zonal harmonic coefficients from the forthcoming Juno orbiter, we present a number of preliminary Jupiter interior models. We combine results from ab initio computer simulations of hydrogen-helium mixtures, including immiscibility calculations, with a new nonperturbative calculation of Jupiter's zonal harmonic coefficients, to derive a self-consistent model for the planet's external gravity and moment of inertia. We assume helium rain modified the interior temperature and composition profiles. Our calculation predicts zonal harmonic values to which measurements can be compared. Although some models fit the observed (pre-Juno) second- and fourth-order zonal harmonics to within their error bars, our preferred reference model predicts a fourth-order zonal harmonic whose absolute value lies above the pre-Juno error bars. This model has a dense core of about 12 Earth masses, and a hydrogen-helium-rich envelope with...

  18. A Preliminary Jupiter Model

    Science.gov (United States)

    Hubbard, W. B.; Militzer, B.

    2016-03-01

    In anticipation of new observational results for Jupiter's axial moment of inertia and gravitational zonal harmonic coefficients from the forthcoming Juno orbiter, we present a number of preliminary Jupiter interior models. We combine results from ab initio computer simulations of hydrogen-helium mixtures, including immiscibility calculations, with a new nonperturbative calculation of Jupiter's zonal harmonic coefficients, to derive a self-consistent model for the planet's external gravity and moment of inertia. We assume helium rain modified the interior temperature and composition profiles. Our calculation predicts zonal harmonic values to which measurements can be compared. Although some models fit the observed (pre-Juno) second- and fourth-order zonal harmonics to within their error bars, our preferred reference model predicts a fourth-order zonal harmonic whose absolute value lies above the pre-Juno error bars. This model has a dense core of about 12 Earth masses and a hydrogen-helium-rich envelope with approximately three times solar metallicity.

  19. Aspects of functioning and environmental factors in medical work capacity evaluations of persons with chronic widespread pain and low back pain can be represented by a combination of applicable ICF Core Sets

    Science.gov (United States)

    2012-01-01

    Background Medical work capacity evaluations play a key role in social security schemes because they usually form the basis for eligibility decisions regarding disability benefits. However, the evaluations are often poorly standardized and lack transparency as decisions on work capacity are based on a claimant’s disease rather than on his or her functional capacity. A comprehensive and consistent illustration of a claimant’s lived experience in relation to functioning, applying the International Classification of Functioning, Disability and Health (ICF) and the ICF Core Sets (ICF-CS), potentially enhances transparency and standardization of work capacity evaluations. In our study we wanted to establish whether and how the relevant content of work capacity evaluations can be captured by ICF-CS, using disability claimants with chronic widespread pain (CWP) and low back pain (LBP) as examples. Methods Mixed methods study, involving a qualitative and quantitative content analysis of medical reports. The ICF was used for data coding. The coded categories were ranked according to the percentage of reports in which they were addressed. Relevance thresholds at 25% and 50% were applied. To determine the extent to which the categories above the thresholds are represented by applicable ICF-CS or combinations thereof, measures of the ICF-CS’ degree of coverage (i.e. content validity) and efficiency (i.e. practicability) were defined. Results Focusing on the 25% threshold and combining the Brief ICF-CS for CWP, LBP and depression for CWP reports, the coverage ratio reached 49% and the efficiency ratio 70%. Combining the Brief ICF-CS for LBP, CWP and obesity for LBP reports led to a coverage of 47% and an efficiency of 78%. Conclusions The relevant content of work capacity evaluations involving CWP and LBP can be represented by a combination of applicable ICF-CS. A suitable standard for documenting such evaluations could consist of the Brief ICF-CS for CWP, LBP, and

  20. Initial validation of the Argentinean Spanish version of the PedsQL™ 4.0 Generic Core Scales in children and adolescents with chronic diseases: acceptability and comprehensibility in low-income settings

    Directory of Open Access Journals (Sweden)

    Bauer Gabriela

    2008-08-01

    Full Text Available Abstract Background To validate the Argentinean Spanish version of the PedsQL™ 4.0 Generic Core Scales in Argentinean children and adolescents with chronic conditions and to assess the impact of socio-demographic characteristics on the instrument's comprehensibility and acceptability. Reliability, and known-groups, and convergent validity were tested. Methods Consecutive sample of 287 children with chronic conditions and 105 healthy children, ages 2–18, and their parents. Chronically ill children were: (1 attending outpatient clinics and (2 had one of the following diagnoses: stem cell transplant, chronic obstructive pulmonary disease, HIV/AIDS, cancer, end stage renal disease, complex congenital cardiopathy. Patients and adult proxies completed the PedsQL™ 4.0 and an overall health status assessment. Physicians were asked to rate degree of health status impairment. Results The PedsQL™ 4.0 was feasible (only 9 children, all 5 to 7 year-olds, could not complete the instrument, easy to administer, completed without, or with minimal, help by most children and parents, and required a brief administration time (average 5–6 minutes. People living below the poverty line and/or low literacy needed more help to complete the instrument. Cronbach Alpha's internal consistency values for the total and subscale scores exceeded 0.70 for self-reports of children over 8 years-old and parent-reports of children over 5 years of age. Reliability of proxy-reports of 2–4 year-olds was low but improved when school items were excluded. Internal consistency for 5–7 year-olds was low (α range = 0.28–0.76. Construct validity was good. Child self-report and parent proxy-report PedsQL™ 4.0 scores were moderately but significantly correlated (ρ = 0.39, p Conclusion Results suggest that the Argentinean Spanish PedsQL™ 4.0 is suitable for research purposes in the public health setting for children over 8 years old and parents of children over 5 years old

  1. Aspects of functioning and environmental factors in medical work capacity evaluations of persons with chronic widespread pain and low back pain can be represented by a combination of applicable ICF Core Sets

    Directory of Open Access Journals (Sweden)

    Schwegler Urban

    2012-12-01

    Full Text Available Abstract Background Medical work capacity evaluations play a key role in social security schemes because they usually form the basis for eligibility decisions regarding disability benefits. However, the evaluations are often poorly standardized and lack transparency as decisions on work capacity are based on a claimant’s disease rather than on his or her functional capacity. A comprehensive and consistent illustration of a claimant’s lived experience in relation to functioning, applying the International Classification of Functioning, Disability and Health (ICF and the ICF Core Sets (ICF-CS, potentially enhances transparency and standardization of work capacity evaluations. In our study we wanted to establish whether and how the relevant content of work capacity evaluations can be captured by ICF-CS, using disability claimants with chronic widespread pain (CWP and low back pain (LBP as examples. Methods Mixed methods study, involving a qualitative and quantitative content analysis of medical reports. The ICF was used for data coding. The coded categories were ranked according to the percentage of reports in which they were addressed. Relevance thresholds at 25% and 50% were applied. To determine the extent to which the categories above the thresholds are represented by applicable ICF-CS or combinations thereof, measures of the ICF-CS’ degree of coverage (i.e. content validity and efficiency (i.e. practicability were defined. Results Focusing on the 25% threshold and combining the Brief ICF-CS for CWP, LBP and depression for CWP reports, the coverage ratio reached 49% and the efficiency ratio 70%. Combining the Brief ICF-CS for LBP, CWP and obesity for LBP reports led to a coverage of 47% and an efficiency of 78%. Conclusions The relevant content of work capacity evaluations involving CWP and LBP can be represented by a combination of applicable ICF-CS. A suitable standard for documenting such evaluations could consist of the Brief ICF

  2. Solid0Core Heat-Pipe Nuclear Batterly Type Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Ehud Greenspan

    2008-09-30

    This project was devoted to a preliminary assessment of the feasibility of designing an Encapsulated Nuclear Heat Source (ENHS) reactor to have a solid core from which heat is removed by liquid-metal heat pipes (HP).

  3. Core Java

    CERN Document Server

    Horstmann, Cay S

    2013-01-01

    Fully updated to reflect Java SE 7 language changes, Core Java™, Volume I—Fundamentals, Ninth Edition, is the definitive guide to the Java platform. Designed for serious programmers, this reliable, unbiased, no-nonsense tutorial illuminates key Java language and library features with thoroughly tested code examples. As in previous editions, all code is easy to understand, reflects modern best practices, and is specifically designed to help jumpstart your projects. Volume I quickly brings you up-to-speed on Java SE 7 core language enhancements, including the diamond operator, improved resource handling, and catching of multiple exceptions. All of the code examples have been updated to reflect these enhancements, and complete descriptions of new SE 7 features are integrated with insightful explanations of fundamental Java concepts.

  4. Core Competencies in Information Management Education.

    Science.gov (United States)

    Gorman, G. E.; Corbitt, B. J.

    2002-01-01

    Discusses core competencies in library and information science and in information systems to use as a background for an examination of core competencies in information management. Suggests a set of core competencies and educational outcomes that might be applied to curricula in both developed and developing countries. (Author/LRW)

  5. Advantages of iron core in a tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Bettis, E.S.; Ballou, J.K.; Becraft, W.R.; Peng, Y.K.M.; Watts, H.L.

    1977-01-01

    A quantitative comparison of the iron core vs air core concepts was carried out on a preliminary basis by using a representative tokamak reactor design with the following self-consistent reference parameters. In the area of plasma engineering, poloidal field and MHD equilibrium considerations with an unsaturated iron core is discussed. The question of proper poloidal field coils to maintain D-shaped plasmas of relatively high anti ..beta.. (7%) with a saturated iron core is also discussed. Estimates of the required iron core size, volt seconds, magnetic flux and its influence on force loading on the superconducting toroidal field coils are shown. Conceptual designs of the mechanical structure of an iron core device are presented. Favorable impacts on the OH power supply cost and complexity are indicated.

  6. 小型自然循环钠冷堆堆芯初步设计研究%Preliminary Design Research on Core of Small Natural-circulation Sodium-cooled Reactor

    Institute of Scientific and Technical Information of China (English)

    陆道纲; 张勋

    2014-01-01

    A small natural-circulation sodium-cooled reactor-AM TEC system was pres-ented as a distributed generation system . According to the criticality calculation and thermal-hydraulic analysis of the core when the total fuel mass was constant ,the influ-ence of pellet radius ,fuel pin length and the number of rings of fuel pins upon the effec-tive multiplication factor kef , pressure drop across the core and heat transfer was analyzed .Additionally ,the B4 C absorber thickness and beginning-of-life excess reactivi-ty under different numbers of rings of the fuel pins were studied when the assumed addi-tional shutdown margin was different .The results show that decreasing the number of rings and active fuel length would increase kef and decrease pressure drop across the core w hen the core equivalent diameter and total cross-sectional area of the coolant channel are unchanged .In order to increase additional shutdow n margin ,the absorber thickness should be increased while the beginning-of-life excess reactivity and power plant econo-my would decrease .%提出了一种适用于分布式发电系统的小型自然循环钠冷堆-AMTEC系统。通过对堆芯的临界计算和热工水力分析,研究了堆芯燃料装载量不变情况下,芯块半径、燃料棒长度和圈数对堆芯有效增殖因数 kef 、堆芯压降和传热的影响。同时分析了不同额外停堆裕量下,B4 C吸收层厚度和堆芯初始剩余反应性随燃料棒圈数的变化关系。计算结果表明:保持堆芯当量直径和冷却剂通道总截面积不变的情况下,减少燃料棒圈数和活性区长度不仅可增加 kef ,且能降低堆芯压降;为提高额外停堆裕量需增加吸收层厚度,但降低了堆芯初始剩余反应性,不利于电厂的经济性。

  7. 基于GDT的聚变裂变混合堆堆芯参数初步设计研究%Preliminary design of core plasma parameters for the fusion-fission hybrid reactor based on GDT

    Institute of Scientific and Technical Information of China (English)

    陈德鸿; 杜红飞; 蒋洁琼; 汪晖; 王福琼; 陈一平; 吴宜灿; FDS团队

    2012-01-01

    Based on the recent experiment progress of Gas Dynamic Trap (GDT), a core plasma physics conceptual design for driving fission blanket was proposed The 0-D physical model was built and the core plasma parameters with 50 MW fusion power were preliminarily designed The reliability of the physical model and design was demonstrated by comparison between the calculation and the experiment results.%基于Gas Dynamic Trap(GDT)装置的实验进展,提出了用于驱动聚变裂变混合堆包层的聚变堆芯参数设计.基于零维堆芯物理模型,计算分析给出了一套聚变功率为50 MW的初步堆芯参数方案.利用GDT装置的实验结果对该物理模型进行计算对比校验,显示该物理模型和设计参数的可靠性.

  8. Mast cell differentiation and activation is closely linked to expression of genes coding for the serglycin proteoglycan core protein and a distinct set of chondroitin sulfate and heparin sulfotransferases.

    Science.gov (United States)

    Duelli, Annette; Rönnberg, Elin; Waern, Ida; Ringvall, Maria; Kolset, Svein O; Pejler, Gunnar

    2009-12-01

    Serglycin (SG) proteoglycan consists of a small core protein to which glycosaminoglycans of chondroitin sulfate or heparin type are attached. SG is crucial for maintaining mast cell (MC) granule homeostasis through promoting the storage of various basic granule constituents, where the degree of chondroitin sulfate/heparin sulfation is essential for optimal SG functionality. However, the regulation of the SG core protein expression and of the various chondroitin sulfate/heparin sulfotransferases during MC differentiation and activation are poorly understood. Here we addressed these issues and show that expression of the SG core protein, chondroitin 4-sulfotransferase (C4ST)-1, and GalNAc(4S)-6-O-sulfotransferase (GalNAc4S6ST) are closely linked to MC maturation. In contrast, the expression of chondroitin 6-sulfotransferase correlated negatively with MC maturation. The expression of N-deacetylase/N-sulfotransferase (NDST)-2, a key enzyme in heparin synthesis, also correlated strongly with MC maturation, whereas the expression of the NDST-1 isoform was approximately equal at all stages of maturation. MC activation by either calcium ionophore or IgE ligation caused an up-regulated expression of the SG core protein, C4ST-1, and GalNAc4S6ST, accompanied by increased secretion of chondroitin sulfate as shown by biosynthetic labeling experiments. In contrast, NDST-2 was down-regulated after MC activation, suggesting that MC activation modulates the nature of the glycosaminoglycan chains attached to the SG core protein. Taken together, these data show that MC maturation is associated with the expression of a distinct signature of genes involved in SG proteoglycan synthesis, and that MC activation modulates their expression.

  9. Dendroidal sets

    NARCIS (Netherlands)

    Weiss, I.

    2007-01-01

    The thesis introduces the new concept of dendroidal set. Dendroidal sets are a generalization of simplicial sets that are particularly suited to the study of operads in the context of homotopy theory. The relation between operads and dendroidal sets is established via the dendroidal nerve functor wh

  10. Core body temperature in obesity.

    Science.gov (United States)

    Heikens, Marc J; Gorbach, Alexander M; Eden, Henry S; Savastano, David M; Chen, Kong Y; Skarulis, Monica C; Yanovski, Jack A

    2011-05-01

    A lower core body temperature set point has been suggested to be a factor that could potentially predispose humans to develop obesity. We tested the hypothesis that obese individuals have lower core temperatures than those in normal-weight individuals. In study 1, nonobese [body mass index (BMI; in kg/m(2)) temperature-sensing capsules, and we measured core temperatures continuously for 24 h. In study 2, normal-weight (BMI of 18-25) and obese subjects swallowed temperature-sensing capsules to measure core temperatures continuously for ≥48 h and kept activity logs. We constructed daily, 24-h core temperature profiles for analysis. Mean (±SE) daily core body temperature did not differ significantly between the 35 nonobese and 46 obese subjects (36.92 ± 0.03°C compared with 36.89 ± 0.03°C; P = 0.44). Core temperature 24-h profiles did not differ significantly between 11 normal-weight and 19 obese subjects (P = 0.274). Women had a mean core body temperature ≈0.23°C greater than that of men (36.99 ± 0.03°C compared with 36.76 ± 0.03°C; P body temperature. It may be necessary to study individuals with function-altering mutations in core temperature-regulating genes to determine whether differences in the core body temperature set point affect the regulation of human body weight. These trials were registered at clinicaltrials.gov as NCT00428987 and NCT00266500.

  11. System archetype of the "Company &Farmer &Futures,Options" basing on the core of archetype generating set%基于基模生成集核的"公司+农户+期货、期货期权"系统基模

    Institute of Scientific and Technical Information of China (English)

    涂国平; 冷碧滨; 贾仁安

    2011-01-01

    In order to explore better agricultural industrialization organizational model and more succinct complex system analysis method, the concepts of archetype generating set core, archetype core were further proposed and the method using strongly simplified rate variable based in-tree of SD to get minimal archetype core by doing embedding operation and get archetype generating set core from the minimal archetype cores and specific archetype cores and doing inverse transformation of the transformation from rate variable based in-tree of SD to strongly simplified rate variable based in-tree of SD is more succinct was obtained, which provide an more succinct method to do archetype feedback analysis of a complex system. Meantime, we proposed the "Company & Farmer & Futures, Options" that is the optimized pattern of the "Company & Farmer"; used archetype generating set core to generate archetypes,combining with the method of determinant feedback loop computation to systematically analyze "Company & Farmer & Futures, Options" and got that the "Company & Farmer & Futures, Options" has counter-restriction effectiveness to the restriction from market risk, market demand and price.%提出了基模生成集核和基模核的概念,并得出:利用强简化流率基本入树模型作嵌运算生成极小基模核,由极小基模核构成基模生成集核,由基模生成集核生成具有典型意义的基模核并施行从流率基本入树模型至强简化入树模型的逆变换的基模生成方法更为简洁、直观,这为复杂系统的基模反馈分析提供了一个更为简洁的方法,同时,提出了"公司十农户"的优化模式"公司十农户十期货、期货期权",并利用基模生成集核生成基模及行列式反馈环算法对"公司+农户+期货、期货期权"经营模式进行系统反馈分析得出:"公司+农户+期货、期货期权"经营模式对来自市场风险、市场需求和价格的制约具有反制约作用,土地问题是制约该模式的主要因素.

  12. North Korean refugee doctors' preliminary examination scores

    Directory of Open Access Journals (Sweden)

    Sung Uk Chae

    2016-12-01

    Full Text Available Purpose Although there have been studies emphasizing the re-education of North Korean (NK doctors for post-unification of the Korean Peninsula, study on the content and scope of such re-education has yet to be conducted. Researchers intended to set the content and scope of re-education by a comparative analysis for the scores of the preliminary examination, which is comparable to the Korean Medical Licensing Examination (KMLE. Methods The scores of the first and second preliminary exams were analyzed by subject using the Wilcoxon signed rank test. The passing status of the group of NK doctors for KMLE in recent 3 years were investigated. The multiple-choice-question (MCQ items of which difficulty indexes of NK doctors were lower than those of South Korean (SK medical students by two times of the standard deviation of the scores of SK medical students were selected to investigate the relevant reasons. Results The average scores of nearly all subjects were improved in the second exam compared with the first exam. The passing rate of the group of NK doctors was 75%. The number of MCQ items of which difficulty indexes of NK doctors were lower than those of SK medical students was 51 (6.38%. NK doctors’ lack of understandings for Diagnostic Techniques and Procedures, Therapeutics, Prenatal Care, and Managed Care Programs was suggested as the possible reason. Conclusion The education of integrated courses focusing on Diagnostic Techniques and Procedures and Therapeutics, and apprenticeship-style training for clinical practice of core subjects are needed. Special lectures on the Preventive Medicine are likely to be required also.

  13. Preliminary reference Earth model

    Science.gov (United States)

    Dziewonski, Adam M.; Anderson, Don L.

    1981-06-01

    A large data set consisting of about 1000 normal mode periods, 500 summary travel time observations, 100 normal mode Q values, mass and moment of inertia have been inverted to obtain the radial distribution of elastic properties, Q values and density in the Earth's interior. The data set was supplemented with a special study of 12 years of ISC phase data which yielded an additional 1.75 × 10 6 travel time observations for P and S waves. In order to obtain satisfactory agreement with the entire data set we were required to take into account anelastic dispersion. The introduction of transverse isotropy into the outer 220 km of the mantle was required in order to satisfy the shorter period fundamental toroidal and spheroidal modes. This anisotropy also improved the fit of the larger data set. The horizontal and vertical velocities in the upper mantle differ by 2-4%, both for P and S waves. The mantle below 220 km is not required to be anisotropic. Mantle Rayleigh waves are surprisingly sensitive to compressional velocity in the upper mantle. High S n velocities, low P n velocities and a pronounced low-velocity zone are features of most global inversion models that are suppressed when anisotropy is allowed for in the inversion. The Preliminary Reference Earth Model, PREM, and auxiliary tables showing fits to the data are presented.

  14. 应用预成弹性印模桩临床制取桩核印模的初步观察%Preliminary observation of using prefabricated elastomeric post for post and core impression

    Institute of Scientific and Technical Information of China (English)

    孙琼; 施生根; 张凯; 牛忠英; 洪彪; 闫澍

    2014-01-01

    Objective:To investigate the application of a proprietary preformed elastomeric post on preparation of post and core impression in clinical practice. Methods:Seventy endodontically treated single-root canal teeth with large defects of tooth structure were enrolled. The method of using the prefabricated elastomeric impression post proprietarily developed by our research group (experimental group) and the traditional method (control group) were used and evaluated on prepara-tion of post and core impression, respectively. Result: The impression defects in experimental and control groups were 44.29%and 74.29%, and the difference was statistically significant (P<0.01). The apical impression defects in experimental and control groups were 2.96%and 41.43%, and the difference was statistically significant (P<0.01). The post body defects in experimental and control groups were 4.29%and 35.71%, and the difference was statistically significant (P<0.01). The available rate in experiment group was significantly higher than the control (93.75%vs 60.00%). Conclusion:The propri-etary prefabricated elastomeric impression post could improve post and core impression integrity during clinical practice.%目的:评估本课题组自主研制的预成弹性印模桩临床制取桩核印模的效果。方法:用预成弹性印模桩法(实验组)和传统方法(对照组)分别对70颗牙体大面积缺损、根管治疗后要求桩核冠修复的单根管患牙各制取桩核印模,观察两种方法制取桩核印模的完整性。结果:实验组和对照组印模桩核区印模缺陷的发生率分别为44.29%、74.29%,两者之间的差异有统计学意义(P<0.01);实验组和对照组印模缺陷在根尖部的发生率分别为2.96%、41.43%,两者之间的差异有统计学意义(P<0.01);实验组和对照组印模缺陷在桩体部的发生率分别为4.29%、35.71%,两者之间的差异有统计学意义(P<0.01);实验组和对照组桩

  15. Application and Preliminary Validation of Sub-node Technology in Core Code of COSINE Package%COSINE软件包堆芯物理分析程序子网格技术的应用及初步验证

    Institute of Scientific and Technical Information of China (English)

    全国萍; 刘占权; 王苏; 王常辉; 胡啸宇; 许花; 陈义学

    2013-01-01

    The core code of COSINE package uses NEM to solve diffusion equation and NEM is based on the node homogenization theory .In the AP1000 core design process , there are some reasons w hich cause material heterogeneity in the axial direction ,such as the fuel assembly dividing into several areas with different enrichments , the arrangement of spacer grid and the insertion of control rod , and it is needed to be rehomogenization .The re-homogenization can bring error into NEM calculation result because of some hypothesis . The directive phenomenon of the error is control rod cusping effect .Sub-node technology was proposed to solve the material heterogeneity in the axial direction problem in this paper ,and the differential worth of control rod was calculated .The results show that the control rod cusping effect greatly reduces because of the sub-node technology .%COSINE软件包堆芯物理分析程序采用节块展开法(NEM )进行中子扩散方程的求解,NEM 以节块均匀化理论为基础。在A P1000堆芯核设计过程中,由于燃料组件的多种轴向材料分区方式、定位格架分布及控制棒插入均会引起节块轴向材料不均匀,需进行再均匀化处理。由于再均匀化过程基于一些假设,给NEM计算带来了一定误差。这种误差最为直接的表现形式为控制棒的尖端效应。本文采用了子网格技术来处理轴向材料不均匀性的问题,并给出了初步验证结果,计算了控制棒的微分价值曲线。计算结果表明,子网格的应用有效地缓解了控制棒尖端效应的影响。

  16. The Shift of Perspectives in Education and Communication of Core Socialist Values on New Media Age:Based on Agenda Setting Theory%新媒体时代社会主义核心价值观教育与传播的视角转换--以议程设置理论为依据

    Institute of Scientific and Technical Information of China (English)

    洪涛; 申芳芳

    2015-01-01

    社会主义核心价值观是当今中国社会发展的主导思想和价值追求。新媒体时代,信息渠道的扩展为社会主义核心价值观的教育与传播提供了新环境和新机遇,同时也给其带来严峻挑战。议程设置理论是传播学中重要的传播效果理论,将其科学引入社会主义核心价值观教育与传播中具有无可比拟的优势。议程设置理论可为社会主义核心价值观的教育与传播提供理论支撑、引导原则、承载工具、借鉴方法和目标指向,在社会主义核心价值观教育与传播中具有引领作用,有助于提高社会主义核心价值观教育与传播的效率。%Socialist core values is the dominant idea and value pursuit of the development of today's Chinese society. On new media age, with the extending of the information channel, it brings the new environment and opportunity of education and communication of core socialist values, also faced the negative effects and challenge. Agenda setting theory is the important theory of communication effect. In the communication, it would have an unparalleled advantage if it introduced the agenda setting theory in education and com-munication of socialist core values. Agenda setting theory provides theoretical support, the principle of guiding, carrying tools, reference and goal oriented to education and communication of socialist core values. It has the role of leading on education and commu-nication of the socialist core values, and increases the efficiency of education and communication of core socialist values.

  17. Scaling Turbo Boost to a 1000 cores

    CERN Document Server

    S, Ananth Narayan; Fedorova, Alexandra

    2010-01-01

    The Intel Core i7 processor code named Nehalem provides a feature named Turbo Boost which opportunistically varies the frequencies of the processor's cores. The frequency of a core is determined by core temperature, the number of active cores, the estimated power consumption, the estimated current consumption, and operating system frequency scaling requests. For a chip multi-processor(CMP) that has a small number of physical cores and a small set of performance states, deciding the Turbo Boost frequency to use on a given core might not be difficult. However, we do not know the complexity of this decision making process in the context of a large number of cores, scaling to the 100s, as predicted by researchers in the field.

  18. Preliminary Study on the High Efficiency Supercritical Pressure Water-Cooled Reactor for Electricity Generation

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Yoon Yeong; Park, Jong Kyun; Cho, Bong Hyun and others

    2006-01-15

    This research has been performed to introduce a concept of supercritical pressure water cooled reactor(SCWR) in Korea The area of research includes core conceptual design, evaluation of candidate fuel, fluid systems conceptual design with mechanical consideration, preparation of safety analysis code, and construction of supercritical pressure heat transfer test facility, SPHINX, and preliminary test. As a result of the research, a set of tools for the reactor core design has been developed and the conceptual core design with solid moderator was proposed. The direct thermodynamic cycle has been studied to find a optimum design. The safety analysis code has also been adapted to supercritical pressure condition. A supercritical pressure CO2 heat transfer test facility has been constructed and preliminary test proved the facility works as expected. The result of this project will be good basis for the participation in the international collaboration under GIF GEN-IV program and next 5-year mid and long term nuclear research program of MOST. The heat transfer test loop, SPHINX, completed as a result of this project may be used for the power cycle study as well as further heat transfer study for the various geometries.

  19. Who Actually Sets the Criteria for Social Studies Literacy? The National Core Curricula and the Matriculation Examination as Guidelines for Social Studies Teaching in Finland in the 2000’s

    Directory of Open Access Journals (Sweden)

    Jan Löfström

    2010-12-01

    Full Text Available The issue of how to define the content of social studies literacy has become topical in Finland in the 2000’s in a new way as a result of social studies having been instituted as an independent subject in upper secondary school and in basic education. Freedom from the ties confining social studies in the role of a subdivision of the subject history has entailed a need to profile social studies and also to problematize the parametres of social studies literacy more clearly and consciously than before. However the question remains as to who defines the content of social studies literacy. In this article we will argue that in Finland today the most central role in this respect is being played not by the national core curricula where the competence aims of social studies teaching are rather vague, but by the social studies exam in the national matriculation examination. This is not necessarily a bad situation in terms of the outcome but it is noteworthy that the task of operationalizing social studies literacy is here as if “outsourced” to a small group of social science and social studies education experts who design social studies exam questions, whereas the authority responsible for developing the national core curricula only sanctions very general descriptive objectives for social studies teaching.

  20. A PRELIMINARY JUPITER MODEL

    Energy Technology Data Exchange (ETDEWEB)

    Hubbard, W. B. [Lunar and Planetary Laboratory, The University of Arizona, Tucson, AZ 85721 (United States); Militzer, B. [Department of Earth and Planetary Science, Department of Astronomy, University of California, Berkeley, CA 94720 (United States)

    2016-03-20

    In anticipation of new observational results for Jupiter's axial moment of inertia and gravitational zonal harmonic coefficients from the forthcoming Juno orbiter, we present a number of preliminary Jupiter interior models. We combine results from ab initio computer simulations of hydrogen–helium mixtures, including immiscibility calculations, with a new nonperturbative calculation of Jupiter's zonal harmonic coefficients, to derive a self-consistent model for the planet's external gravity and moment of inertia. We assume helium rain modified the interior temperature and composition profiles. Our calculation predicts zonal harmonic values to which measurements can be compared. Although some models fit the observed (pre-Juno) second- and fourth-order zonal harmonics to within their error bars, our preferred reference model predicts a fourth-order zonal harmonic whose absolute value lies above the pre-Juno error bars. This model has a dense core of about 12 Earth masses and a hydrogen–helium-rich envelope with approximately three times solar metallicity.

  1. Preliminary organizational culture scale focused on artifacts.

    Science.gov (United States)

    Bonavia, Tomas

    2006-12-01

    In this preliminary study, an Organizational Culture Scale was developed to assess cultural artifacts according to Schein's typology (1985). It includes a set of cultural artifacts to measure the extent to which an organization is more or less traditional. A total of 249 managers from a range of different companies responded to the items. Preliminary analysis yielded a one-dimensional scale with 14 items with high internal consistency and homogeneity.

  2. Preliminary organizational culture scale focused on artifacts

    OpenAIRE

    Bonavia, Tomas

    2006-01-01

    In this preliminary study, an organizational culture scale was developed to assess cultural artifacts according to Schein´s typology (1985). It includes a set of cultural artifacts to measure the extent to which an organization is more or less traditional. A total of 249 managers from a range of different companies responded to the items. Preliminary analysis yielded a one-dimensional scale with 14 items with high internal consistency and homogeneity.

  3. Preliminary Monthly Climatological Summaries

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Preliminary Local Climatological Data, recorded since 1970 on Weather Burean Form 1030 and then National Weather Service Form F-6. The preliminary climate data pages...

  4. A Comparison of Embedded Total Task Instruction in Teaching Behavioral Chains to Massed One-on-One Instruction for Students with Intellectual Disabilities: Accessing General Education Settings and Core Academic Content

    Science.gov (United States)

    Jameson, J. Matt; Walker, Ryan; Utley, Kristen; Maughan, Ryan

    2012-01-01

    This study is a comparison of the embedded instruction of behavioral chains with more traditional (one-on-one massed trials in special education setting) instructional procedures for teaching behavioral chains to students with significant cognitive disabilities. Although embedded instruction has emerged as a promising potential instructional…

  5. Dual-core antiresonant hollow core fibers.

    Science.gov (United States)

    Liu, Xuesong; Fan, Zhongwei; Shi, Zhaohui; Ma, Yunfeng; Yu, Jin; Zhang, Jing

    2016-07-25

    In this work, dual-core antiresonant hollow core fibers (AR-HCFs) are numerically demonstrated, based on our knowledge, for the first time. Two fiber structures are proposed. One is a composite of two single-core nested nodeless AR-HCFs, exhibiting low confinement loss and a circular mode profile in each core. The other has a relatively simple structure, with a whole elliptical outer jacket, presenting a uniform and wide transmission band. The modal couplings of the dual-core AR-HCFs rely on a unique mechanism that transfers power through the air. The core separation and the gap between the two cores influence the modal coupling strength. With proper designs, both of the dual-core fibers can have low phase birefringence and short modal coupling lengths of several centimeters.

  6. Diseño y validación de un instrumento de evaluación de la discapacidad en personas con lesión medular crónica basado en el CORE SET abreviado de la CIF

    OpenAIRE

    Agudelo Martínez, Ayda Zulamy; Valencia Nogales, Eliana; Henao Lema, Claudia Patricia; Pérez Parra, Julio Ernesto

    2013-01-01

    El propósito del macroproyecto fue diseñar y validar un instrumento de valoración de la discapacidad de las personas con lesión medular crónica en sus componentes actividades, participación y factores ambientales, basado en el Core Set abreviado de la CIF, y evaluarlo en sus características de congruencia interna, validez concurrente, y confiabilidad interevaluador e intraevaluador. El estudio se desarrolló bajo el enfoque empírico-analítico realizándose un estudio de tipo descriptiv...

  7. Diseño y validación de un instrumento de evaluación de la discapacidad en personas con lesión medular crónica, basado en el Core Set abreviado de la CIF

    OpenAIRE

    2014-01-01

    El propósito del macroproyecto fue diseñar y validar un instrumento de valoración de la discapacidad de las personas con lesión medular crónica en sus componentes actividades, participación y factores ambientales, basado en el Core Set abreviado de la CIF, y evaluarlo en sus características de congruencia interna, validez concurrente, y confiabilidad interevaluador e intraevaluador. El estudio se desarrolló bajo el enfoque empírico-analítico realizándose un estudio de tipo descriptiv...

  8. Annual Accumulation Data from 1997 and 1998 PARCA Ice Cores

    Data.gov (United States)

    National Aeronautics and Space Administration — This data set contains annual accumulation data in water equivalent from 14 ice cores collected in 1997 and 16 ice cores collected in 1998. Data are provided in...

  9. Assessment on the Cohesion Pattern of Rail Transit: Integration of Rough Set and Grey Correlation Theory

    Directory of Open Access Journals (Sweden)

    Yang Zhijie

    2016-01-01

    Full Text Available Most existing project assessment relies on expert scoring, whose precision can be deteriorated by personal subjectivity. This paper presents an assessment method to compare the advantages and disadvantages of three cohesion patterns between suburban and urban rail transit network, which reduces the influence of subjective score. A modified rough set – grey correlation model is developed as a core of this assessment, based on the integration of rough set theory and grey correlational analysis, where an index system is set up for model calculation. A case study using the network in Ningbo is applied to demonstrate the effectiveness of the method, the results show that the method is more effective using discretely distributed data sensitive to sample size. The consistency of the results in comparison with marginal cost analysis can be a preliminary verification of the model.

  10. Animal MRI Core

    Data.gov (United States)

    Federal Laboratory Consortium — The Animal Magnetic Resonance Imaging (MRI) Core develops and optimizes MRI methods for cardiovascular imaging of mice and rats. The Core provides imaging expertise,...

  11. Continuous greenhouse gas measurements from ice cores

    DEFF Research Database (Denmark)

    Stowasser, Christopher

    several applications of the new continuous data sets: (1) Past atmospheric mixing ratios of methane were measured along ca. 800 m of the deep ice core from the North Greenland Eemian Ice Core Drilling project (NEEM) covering almost the complete last glaciation and deglaciation. The record reveals new sub-millennial...

  12. No Common Opinion on the Common Core

    Science.gov (United States)

    Henderson, Michael B.; Peterson, Paul E.; West, Martin R.

    2015-01-01

    According to the three authors of this article, the 2014 "EdNext" poll yields four especially important new findings: (1) Opinion with respect to the Common Core has yet to coalesce. The idea of a common set of standards across the country has wide appeal, and the Common Core itself still commands the support of a majority of the public.…

  13. Bioinformatics and Computational Core Technology Center

    Data.gov (United States)

    Federal Laboratory Consortium — SERVICES PROVIDED BY THE COMPUTER CORE FACILITYEvaluation, purchase, set up, and maintenance of the computer hardware and network for the 170 users in the research...

  14. Bioinformatics and Computational Core Technology Center

    Data.gov (United States)

    Federal Laboratory Consortium — SERVICES PROVIDED BY THE COMPUTER CORE FACILITY Evaluation, purchase, set up, and maintenance of the computer hardware and network for the 170 users in the research...

  15. The CORE study protocol: a stepped wedge cluster randomised controlled trial to test a co-design technique to optimise psychosocial recovery outcomes for people affected by mental illness in the community mental health setting

    Science.gov (United States)

    Palmer, Victoria J; Chondros, Patty; Piper, Donella; Callander, Rosemary; Weavell, Wayne; Godbee, Kali; Potiriadis, Maria; Richard, Lauralie; Densely, Konstancja; Herrman, Helen; Furler, John; Pierce, David; Schuster, Tibor; Iedema, Rick; Gunn, Jane

    2015-01-01

    Introduction User engagement in mental health service design is heralded as integral to health systems quality and performance, but does engagement improve health outcomes? This article describes the CORE study protocol, a novel stepped wedge cluster randomised controlled trial (SWCRCT) to improve psychosocial recovery outcomes for people with severe mental illness. Methods An SWCRCT with a nested process evaluation will be conducted over nearly 4 years in Victoria, Australia. 11 teams from four mental health service providers will be randomly allocated to one of three dates 9 months apart to start the intervention. The intervention, a modified version of Mental Health Experience Co-Design (MH ECO), will be delivered to 30 service users, 30 carers and 10 staff in each cluster. Outcome data will be collected at baseline (6 months) and at completion of each intervention wave. The primary outcome is improvement in recovery score using the 24-item Revised Recovery Assessment Scale for service users. Secondary outcomes are improvements to user and carer mental health and well-being using the shortened 8-item version of the WHOQOL Quality of Life scale (EUROHIS), changes to staff attitudes using the 19-item Staff Attitudes to Recovery Scale and recovery orientation of services using the 36-item Recovery Self Assessment Scale (provider version). Intervention and usual care periods will be compared using a linear mixed effects model for continuous outcomes and a generalised linear mixed effects model for binary outcomes. Participants will be analysed in the group that the cluster was assigned to at each time point. Ethics and dissemination The University of Melbourne, Human Research Ethics Committee (1340299.3) and the Federal and State Departments of Health Committees (Project 20/2014) granted ethics approval. Baseline data results will be reported in 2015 and outcomes data in 2017. Trial registration number Australian and New Zealand Clinical Trials Registry ACTRN

  16. The reliability and validity of the brief International Classification of Functioning, Disability and Health core sets for Chinese stroke patients%脑卒中简明ICF核心要素信和效度检验的Rasch模型分析

    Institute of Scientific and Technical Information of China (English)

    卫小梅; 胡昔权; 窦祖林; 郭铁成; 喻勇

    2011-01-01

    目的 运用多层面Rasch模型检验中国版脑卒中国际功能、残疾与健康分类(ICF)核心要素的信度和效度.方法 由2名评定员对38例脑卒中患者采用中国版简明ICF核心要素的"身体功能"成分包含的20个类目分别进行评分,运用FACETS统计软件计算个人分离指数和信度、拟合分析等检验ICF核心要素的信度和效度.结果 中国版简明ICF核心要素量表中"身体功能"成分类目内部一致性信度好(个人分离指数为6.02,分离信度为0.94,χ2=2158.3,P<0.01),评定者内信度好(未加权的均方拟合统计量为0.92~1.12),但2位评定员评分时的严格程度有显著差异(χ2=1042.5,P=0.01).该部分量表的结构效度较好(分离指数为1050,分离信度为0.80,χ2=467.3,P=0.01).但是拟合分析表明,b117智力功能处于非拟合状态,而b152情感功能和b755不随意运动反应功能处于过度拟合状态.结论 中国版脑卒中简明ICF核心要素的身体功能成分具有良好的信度和结构效度.多层面 Rasch模型对于检验简明ICF核心要素的信度和效度能够提供更全面的信息,具有良好应用前景.%Objective To test the reliability and validity of the brief International Classification of Functioning, Disability and Health (ICF) core sets for Chinese stroke patients using Rasch model analysis. Methods The body functions of 38 Chinese stroke patients were measured using the brief ICF core sets. The qualifiers of the 20items were measured by two raters and analyzed using FACETS statistical software. The intra-rater reliability and validity were tested by using the separation index and separation reliability and fit analysis. Results The brief ICF core sets had good internal consistency and reliability (person separation index = 6.02, person separation reliability = 0.94 ) with these Chinese patients. The raters showed significantly different strictness in rating, but their ratings had good internal self

  17. 脑卒中国际功能残疾和健康分类简要核心组合的信度与效度研究%Study on the reliability and validity of international classification of function,disability and health brief core sets for stroke

    Institute of Scientific and Technical Information of China (English)

    曹蓉; 许光旭; 丁晓晶; 林枫; 励建安

    2011-01-01

    目的:分析研究脑卒中国际功能、残疾和健康分类(ICF )简要核心组合的信度和效度.方法:选择50例脑卒中患者,采用国际脑卒中ICF简要核心组合、美国国立卫生研究院卒中量表(NIHSS)、Fugl-Meyer运动功能量表(FM)、Barthel指数(BI)进行评定.评定者间信度采用Kappa一致性分析方法;同步效度采用Spearman相关分析.结果:身体功能中的四个类目意识功能、定向功能、语言精神功能和肌肉力量功能的kappa值为0.664-1.000,信度中度到优;身体结构的类目脑的结构kappa值为0.976,信度优;活动和参与的四个类目的kappa值为0.696-0.846,信度中度到优;环境因素的类目直系亲属家庭kappa值为0.450,信度中度.ICF除"e310直系亲属家庭"外的其他项目的总分与NIHSS,Fugl-Meyer,BI评分的Spearman相关系数分别为0.795、-0.866、-0.795(P<0.01).结论:采用国际脑卒中ICF简要核心组合对脑卒中患者进行综合评定可靠有效.%Objective: To analyze and study the inter-rater reliability and validity of international classification of functioning, disability and health(ICF) brief core sets for stroke.Method: Fifty stroke patients were involved in this study. The functional evaluation were assessed by ICF brief core sets for stroke, National Institutes of Health Stroke Scale (NIHSS), Fugl-Meyer motor scale(FM) and Barthel index (BI). The inter-rater reliability was analyzed using Kappa correlation statistics. The concurrent criterion validity was analyzed by Spearman rank correlation coefficients.Result: The categories of ICF brief core sets for stroke had moderate to excellent inter-rater reliability (Kappa value 0.450-1.000). Correlation analyses showed that the total score of brief core sets were highly associated with scores of NIHSS, FM and BI. Spearman's rho in NIHSS, FM and BI were 0.795, -0.866 and -0.795, respectively (P<0.01).Conclusion: The ICF brief core sets for stroke is reliable and valid as a

  18. The CORE study protocol: a stepped wedge cluster randomised controlled trial to test a co-design technique to optimise psychosocial recovery outcomes for people affected by mental illness in the community mental health setting.

    Science.gov (United States)

    Palmer, Victoria J; Chondros, Patty; Piper, Donella; Callander, Rosemary; Weavell, Wayne; Godbee, Kali; Potiriadis, Maria; Richard, Lauralie; Densely, Konstancja; Herrman, Helen; Furler, John; Pierce, David; Schuster, Tibor; Iedema, Rick; Gunn, Jane

    2015-03-24

    User engagement in mental health service design is heralded as integral to health systems quality and performance, but does engagement improve health outcomes? This article describes the CORE study protocol, a novel stepped wedge cluster randomised controlled trial (SWCRCT) to improve psychosocial recovery outcomes for people with severe mental illness. An SWCRCT with a nested process evaluation will be conducted over nearly 4 years in Victoria, Australia. 11 teams from four mental health service providers will be randomly allocated to one of three dates 9 months apart to start the intervention. The intervention, a modified version of Mental Health Experience Co-Design (MH ECO), will be delivered to 30 service users, 30 carers and 10 staff in each cluster. Outcome data will be collected at baseline (6 months) and at completion of each intervention wave. The primary outcome is improvement in recovery score using the 24-item Revised Recovery Assessment Scale for service users. Secondary outcomes are improvements to user and carer mental health and well-being using the shortened 8-item version of the WHOQOL Quality of Life scale (EUROHIS), changes to staff attitudes using the 19-item Staff Attitudes to Recovery Scale and recovery orientation of services using the 36-item Recovery Self Assessment Scale (provider version). Intervention and usual care periods will be compared using a linear mixed effects model for continuous outcomes and a generalised linear mixed effects model for binary outcomes. Participants will be analysed in the group that the cluster was assigned to at each time point. The University of Melbourne, Human Research Ethics Committee (1340299.3) and the Federal and State Departments of Health Committees (Project 20/2014) granted ethics approval. Baseline data results will be reported in 2015 and outcomes data in 2017. Australian and New Zealand Clinical Trials Registry ACTRN12614000457640. Published by the BMJ Publishing Group Limited. For

  19. Preliminary Report on Unique Laminated Holocene Sediments from the Qarun Lake in Egypt

    Directory of Open Access Journals (Sweden)

    Marks Leszek

    2016-06-01

    Full Text Available The Lake Qarun (Faiyum Oasis, northern Egypt is a relic of the much larger Holocene lake. Past lake levels and extensions were reconstructed, based on setting of archaeological sites scattered along northern paleoshores of the ancient lake. However, geoarcheological works did not yield enough data to establish continuous environmental history of the lake. A deep drilling FA-1 on the southeastern shore of the lake, performed in 2014, supplied with a core, 26 m long that is the one of the longest lake sediment cores in northeastern Africa. The basal section of the core consisted of thin-laminated diatom marly deposits, underlain at the Late Pleistocene/Holocene boundary by coarse-grained sands. The sediment lamine were quite well developed, especially in the lower part of the core. Preliminary results indicated annually deposited sediment sequence with seasonality signals provided by microlamine of diatoms, calcite, organic matter and clastic material. Early Holocene varved sediments from the Faiyum Oasis supplied with exceptional paleoenvironmental data for northeastern Africa, which enriched a record from previous logs drilled at the southwestern margin of the Qarun Lake.

  20. Utilization of Genetic Diversity on Establishing Chinese Soybean (G.max0 Core Collection

    Institute of Scientific and Technical Information of China (English)

    QiuLijuan; XieHua; ChangRuzhen; LiWei; WangWenhui; ZhangBo; ZhangMinghui; FengZhongfu

    2002-01-01

    Genetic diversity plays a very important role in establishing core collection.In this study,A total of 405 Chinese soybean accessions was selected from the preliminary core collection,which had 5 different ecotypes from three cultivation regions,including northeastern spring sowing soybean(NSpSS),huanghuai summer sowing soybean(HSuSS),southern spring sowing soybean(SSpSS),southern summer sowing soybean(SSuSS),southern autumn sowing soybean(SAuSS).The genetic diversities and genetic relationship of five ecotypes were analyzed at DNA level by using SSR markers in order to provide information for establishemnt of Chinese soybean core collection.A set of 67 SSR primers were used to analyze these accessions,and detected 502 alleles with averaged 7.49 alleles per locus.SAuSS appeared to be the highest number of alleles,HSuSS had the biggest genetic diversity indexes and NSpSS were lowest for both numbers of alleles and genetic diversity indexes among 5 ecotypes.Since five ecotypes differentiated obviously,various sampling strategy for establishing core collection should be adaped for different ecotypes based on the number of alleles and genetic diversity indexes.

  1. Distributed k-Core Decomposition

    CERN Document Server

    Montresor, Alberto; Miorandi, Daniele

    2011-01-01

    Among the novel metrics used to study the relative importance of nodes in complex networks, k-core decomposition has found a number of applications in areas as diverse as sociology, proteinomics, graph visualization, and distributed system analysis and design. This paper proposes new distributed algorithms for the computation of the k-core decomposition of a network, with the purpose of (i) enabling the run-time computation of k-cores in "live" distributed systems and (ii) allowing the decomposition, over a set of connected machines, of very large graphs, that cannot be hosted in a single machine. Lower bounds on the algorithms complexity are given, and an exhaustive experimental analysis on real-world graphs is provided.

  2. Failure to maintain set as a predictor of childhood depression within a children's psychiatric inpatient sample.

    Science.gov (United States)

    Kavanaugh, Brian C; Gaudet, Charles E; Dupont-Frechette, Jennifer A; Tellock, Perrin P; Maher, Isolde D; Haisley, Lauren D; Holler, Karen A

    2016-12-30

    Despite a wealth of studies in adults and adolescents, only a handful of studies have examined executive function in childhood depression. This study utilized retrospective chart review of a children's psychiatric inpatient program to evaluate executive function via Wisconsin Card Sorting Test (WCST) in 33 children (6-12 years old) with a depressive disorder and 61 age/sex-matched children without a depressive disorder referred for neuropsychological evaluation. WCST categories, perseverative errors, and failure to maintain set errors were examined as potential predictors of depressive disorder diagnosis and self-reported depressive symptoms. After controlling for age, length of hospital stay, and ADHD, failure to maintain set significantly predicted depressive disorder diagnosis. Failure to maintain set was also significantly associated with self-reported depressive symptoms. Current findings provide preliminary evidence to suggest that failure to maintain set may reflect a core deficit of childhood depression. While findings are preliminary, this may have important implications for the diagnosis and treatment of childhood depression.

  3. Constructive Sets in Computable Sets

    Institute of Scientific and Technical Information of China (English)

    傅育熙

    1997-01-01

    The original interpretation of the constructive set theory CZF in Martin-Loef's type theory uses the‘extensional identity types’.It is generally believed that these‘types’do not belong to type theory.In this paper it will be shown that the interpretation goes through without identity types.This paper will also show that the interpretation can be given in an intensional type theory.This reflects the computational nature of the interpretation.This computational aspect is reinforced by an ω-Set moel of CZF.

  4. Contraction core for horn belief change: preliminary report

    CSIR Research Space (South Africa)

    Booth, R

    2010-05-01

    Full Text Available logic, and address both the issues mentioned above, as well as others. We bring into the picture a con- struction method for contraction first introduced by Hans- son (1994), known as kernel contraction. Although ker- nel contraction is usually...- traction satisfies (B − 1)–(B − 4). Conversely, every base contraction which satisfies (B−1)–(B−4) is a base partial meet contraction. Kernel contraction was introduced by Hans- son (1994) as a generalization of safe contrac- tion (Alchourro...

  5. Cool Core Clusters from Cosmological Simulations

    CERN Document Server

    Rasia, E; Murante, G; Planelles, S; Beck, A M; Biffi, V; Ragone-Figueroa, C; Granato, G L; Steinborn, L K; Dolag, K

    2015-01-01

    We present results obtained from a set of cosmological hydrodynamic simulations of galaxy clusters, aimed at comparing predictions with observational data on the diversity between cool-core and non-cool-core clusters. Our simulations include the effects of stellar and AGN feedback and are based on an improved version of the Smoothed-Particle-Hydrodynamics code GADGET-3, which ameliorates gas mixing and better captures gas-dynamical instabilities by including a suitable artificial thermal diffusion. In this Letter, we focus our analysis on the entropy profiles, our primary diagnostic to classify the degree of cool-coreness of clusters, and on the iron profiles. In keeping with observations, our simulated clusters display a variety of behaviors in entropy profiles: they range from steadily decreasing profiles at small radii, characteristic of cool-core systems, to nearly flat core isentropic profiles, characteristic of non cool-core systems. Using observational criteria to distinguish between the two classes of...

  6. Conversational Competence in Academic Settings

    Science.gov (United States)

    Bowman, Richard F.

    2014-01-01

    Conversational competence is a process, not a state. Ithaca does not exist, only the voyage to Ithaca. Vibrant campuses are a series of productive conversations. At its core, communicative competence in academic settings mirrors a collective search for meaning regarding the purpose and direction of a campus community. Communicative competence…

  7. Conversational Competence in Academic Settings

    Science.gov (United States)

    Bowman, Richard F.

    2014-01-01

    Conversational competence is a process, not a state. Ithaca does not exist, only the voyage to Ithaca. Vibrant campuses are a series of productive conversations. At its core, communicative competence in academic settings mirrors a collective search for meaning regarding the purpose and direction of a campus community. Communicative competence…

  8. k-core covers and the core

    NARCIS (Netherlands)

    Sanchez-Rodriguez, E.; Borm, Peter; Estevez-Fernandez, A.; Fiestras-Janeiro, G.; Mosquera, M.A.

    2015-01-01

    This paper extends the notion of individual minimal rights for a transferable utility game (TU-game) to coalitional minimal rights using minimal balanced families of a specific type, thus defining a corresponding minimal rights game. It is shown that the core of a TU-game coincides with the core of

  9. Academic Rigor: The Core of the Core

    Science.gov (United States)

    Brunner, Judy

    2013-01-01

    Some educators see the Common Core State Standards as reason for stress, most recognize the positive possibilities associated with them and are willing to make the professional commitment to implementing them so that academic rigor for all students will increase. But business leaders, parents, and the authors of the Common Core are not the only…

  10. k-core covers and the core

    NARCIS (Netherlands)

    Sanchez-Rodriguez, E.; Borm, Peter; Estevez-Fernandez, A.; Fiestras-Janeiro, G.; Mosquera, M.A.

    This paper extends the notion of individual minimal rights for a transferable utility game (TU-game) to coalitional minimal rights using minimal balanced families of a specific type, thus defining a corresponding minimal rights game. It is shown that the core of a TU-game coincides with the core of

  11. Preliminary classification criteria for the cryoglobulinaemic vasculitis

    Science.gov (United States)

    De Vita, S; Soldano, F; Isola, M; Monti, G; Gabrielli, A; Tzioufas, A; Ferri, C; Ferraccioli, G F; Quartuccio, L; Corazza, L; De Marchi, G; Casals, M Ramos; Voulgarelis, M; Lenzi, M; Saccardo, F; Fraticelli, P; Mascia, M T; Sansonno, D; Cacoub, P; Tomsic, M; Tavoni, A; Pietrogrande, M; Zignego, A L; Scarpato, S; Mazzaro, C; Pioltelli, P; Steinfeld, S; Lamprecht, P; Bombardieri, S; Galli, M

    2011-01-01

    Background To develop preliminary classification criteria for the cryoglobulinaemic syndrome or cryoglobulinaemic vasculitis (CV). Methods Study part I developed a questionnaire for CV to be included in the formal, second part (study part II). Positivity of serum cryoglobulins was defined by experts as an essential condition for CV classification. In study part II, a core set of classification items (questionnaire, clinical and laboratory items, as agreed) was tested in three groups of patients and controls—that is, group A (new patients with the CV), group B (controls with serum cryoglobulins but lacking CV) and group C (controls without serum cryoglobulins but with features which can be observed in CV). Results In study part I (188 cases, 284 controls), a positive response to at least two of three selected questions showed a sensitivity of 81.9% and a specificity of 83.5% for CV. This questionnaire was employed and validated in study part II, which included 272 patients in group A and 228 controls in group B. The final classification criteria for CV, by pooling data from group A and group B, required the positivity of questionnaire plus clinical, questionnaire plus laboratory, or clinical plus laboratory items, or all the three, providing a sensitivity of 88.5% and a specificity of 93.6% for CV. By comparing data in group A versus group C (425 controls), the same classification criteria showed a sensitivity 88.5% and a specificity 97.0% for CV. Conclusion Classification criteria for CV were developed, and now need validation. PMID:21571735

  12. A lock circuit for a multi-core processor

    DEFF Research Database (Denmark)

    2015-01-01

    An integrated circuit comprising a multiple processor cores and a lock circuit that comprises a queue register with respective bits set or reset via respective, connections dedicated to respective processor cores, whereby the queue register identifies those among the multiple processor cores that...

  13. Quantum Physics Principles and Communication in the Acute Healthcare Setting: A Pilot Study.

    Science.gov (United States)

    Helgeson, Heidi L; Peyerl, Colleen Kraft; Solheim-Witt, Marit

    This pilot study explores whether clinician awareness of quantum physics principles could facilitate open communication between patients and providers. In the spirit of action research, this study was conceptualized with a holistic view of human health, using a mixed method design of grounded theory as an emergent method. Instrumentation includes surveys and a focus group discussion with twelve registered nurses working in an acute care hospital setting. Findings document that the preliminary core phenomenon, energy as information, influences communication in the healthcare environment. Key emergent themes include awareness, language, validation, open communication, strategies, coherence, incoherence and power. Research participants indicate that quantum physics principles provide a language and conceptual framework for improving their awareness of communication and interactions in the healthcare environment. Implications of this pilot study support the feasibility of future research and education on awareness of quantum physics principles in other clinical settings. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. 37 CFR 1.488 - Determination of unity of invention before the International Preliminary Examining Authority.

    Science.gov (United States)

    2010-07-01

    ... invention before the International Preliminary Examining Authority. 1.488 Section 1.488 Patents, Trademarks... Determination of unity of invention before the International Preliminary Examining Authority. (a) Before... requirement of unity of invention as set forth in § 1.475. (b) If the International Preliminary Examining...

  15. Comodules over semiperfect corings

    CERN Document Server

    Caenepeel, S

    2011-01-01

    We discuss when the Rat functor associated to a coring satisfying the left $\\alpha$-condition is exact. We study the category of comodules over a semiperfect coring. We characterize semiperfect corings over artinian rings and over qF-rings.

  16. Coring Sample Acquisition Tool

    Science.gov (United States)

    Haddad, Nicolas E.; Murray, Saben D.; Walkemeyer, Phillip E.; Badescu, Mircea; Sherrit, Stewart; Bao, Xiaoqi; Kriechbaum, Kristopher L.; Richardson, Megan; Klein, Kerry J.

    2012-01-01

    A sample acquisition tool (SAT) has been developed that can be used autonomously to sample drill and capture rock cores. The tool is designed to accommodate core transfer using a sample tube to the IMSAH (integrated Mars sample acquisition and handling) SHEC (sample handling, encapsulation, and containerization) without ever touching the pristine core sample in the transfer process.

  17. Identifying ELIXIR Core Data Resources.

    Science.gov (United States)

    Durinx, Christine; McEntyre, Jo; Appel, Ron; Apweiler, Rolf; Barlow, Mary; Blomberg, Niklas; Cook, Chuck; Gasteiger, Elisabeth; Kim, Jee-Hyub; Lopez, Rodrigo; Redaschi, Nicole; Stockinger, Heinz; Teixeira, Daniel; Valencia, Alfonso

    2016-01-01

    The core mission of ELIXIR is to build a stable and sustainable infrastructure for biological information across Europe. At the heart of this are the data resources, tools and services that ELIXIR offers to the life-sciences community, providing stable and sustainable access to biological data. ELIXIR aims to ensure that these resources are available long-term and that the life-cycles of these resources are managed such that they support the scientific needs of the life-sciences, including biological research. ELIXIR Core Data Resources are defined as a set of European data resources that are of fundamental importance to the wider life-science community and the long-term preservation of biological data. They are complete collections of generic value to life-science, are considered an authority in their field with respect to one or more characteristics, and show high levels of scientific quality and service. Thus, ELIXIR Core Data Resources are of wide applicability and usage. This paper describes the structures, governance and processes that support the identification and evaluation of ELIXIR Core Data Resources. It identifies key indicators which reflect the essence of the definition of an ELIXIR Core Data Resource and support the promotion of excellence in resource development and operation. It describes the specific indicators in more detail and explains their application within ELIXIR's sustainability strategy and science policy actions, and in capacity building, life-cycle management and technical actions. The identification process is currently being implemented and tested for the first time. The findings and outcome will be evaluated by the ELIXIR Scientific Advisory Board in March 2017. Establishing the portfolio of ELIXIR Core Data Resources and ELIXIR Services is a key priority for ELIXIR and publicly marks the transition towards a cohesive infrastructure.

  18. A CORE approach to progress monitoring and feedback: Enhancing evidence and improving practice.

    Science.gov (United States)

    Barkham, Michael; Mellor-Clark, John; Stiles, William B

    2015-12-01

    This article describes the Clinical Outcomes in Routine Evaluation (CORE) System and reports on its scientific yield and practice impact. First, we describe the suite of CORE measures, including the centerpiece CORE-Outcome Measure (CORE-OM), its short forms, special purpose forms, translations, and psychometric properties, along with the pretreatment CORE Therapy Assessment Form and the CORE End of Therapy Form. Second, we provide an overview of the scientific yield arising from analyses of large CORE data sets collected in routine practice. Third, we describe the use of CORE measures for feedback in practice settings. Finally, we consider future directions for monitoring and feedback in research and practice.

  19. The Cores of Elliptical Galaxies in Coma

    Science.gov (United States)

    Lucey, John

    1995-07-01

    The cores of galaxies are astrophysically unique. They canhost high energy nuclei, star formation and perhaps even blackholes. HST observations have established that the cores ofellipticals are related to their global properties, and so canbe used as diagnostics of the physical processes occurring atthe time of formation. HST images of galaxy cores havedistinguished two different types of core luminosity profiles:`soft' and `hard' types. It is suggested that luminous, slowlyrotating galaxies have `soft' cores and the less luminousdisky galaxies have `hard' cores. This can be interpreted interms of a formation scenario based on a merger hierarchy inwhich the low luminosity systems experience highly dissipativemergers, but as the luminous systems are assembled the mergersbecome increasingly stellar. In this picture, the type of corea galaxy generates is intimately related to its evolutionaryhistory, i.e. the degree of interaction/merging experiencedand the availability of cold gas. In turn, this should notonly depend on luminosity but also on the galaxy's localenvironment. Here we propose to test the gaseous/stellarmerger picture by imaging a set of Coma cluster ellipticalsfrom a wide range of cluster radii. In the gas poorenvironment of the cluster core there may be insufficent coldgas for the low luminosity galaxies to form `hard' cores.Similarly, at the cluster turnround radius even luminousgalaxies may have experienced a dissipative core formation andpossess

  20. Banded transformer cores

    Science.gov (United States)

    Mclyman, C. W. T. (Inventor)

    1974-01-01

    A banded transformer core formed by positioning a pair of mated, similar core halves on a supporting pedestal. The core halves are encircled with a strap, selectively applying tension whereby a compressive force is applied to the core edge for reducing the innate air gap. A dc magnetic field is employed in supporting the core halves during initial phases of the banding operation, while an ac magnetic field subsequently is employed for detecting dimension changes occurring in the air gaps as tension is applied to the strap.

  1. Preliminaries to an investigation of reduced product set finance

    NARCIS (Netherlands)

    Bergstra, J.A.; Middelburg, C.A.

    2011-01-01

    Principles of financial product synthesis from a few basic financial products constitute an interesting research topic inspired by Islamic finance. We make an effort to answer general questions that should be answered before starting to investigate the main issues concerning this topic with the form

  2. Preliminaries to an investigation of reduced product set finance

    NARCIS (Netherlands)

    Bergstra, J.A.; Middelburg, C.A.

    2010-01-01

    Principles of financial product synthesis from a few basic financial products constitute an interesting research topic inspired by Islamic finance. We make an effort to answer general questions that should be answered before starting to investigate the main issues concerning this topic with the form

  3. Evaluation of Ceramic Honeycomb Core Compression Behavior at Room Temperature

    Science.gov (United States)

    Bird, Richard K.; Lapointe, Thomas S.

    2013-01-01

    Room temperature flatwise compression tests were conducted on two varieties of ceramic honeycomb core specimens that have potential for high-temperature structural applications. One set of specimens was fabricated using strips of a commercially-available thin-gage "ceramic paper" sheet molded into a hexagonal core configuration. The other set was fabricated by machining honeycomb core directly from a commercially available rigid insulation tile material. This paper summarizes the results from these tests.

  4. Validation of the ICF core set for neuromuscular diseases

    NARCIS (Netherlands)

    Bos, Isaac; Stallinga, H. A.; Middel, B.; Kuks, J. B. M.; Wynia, K.

    Background. Understanding of the consequences of a neuromuscular disease (NMD) can improve when a valid sample of disease-specific categories based on the International Classification of Functioning, Disabilities, and Health (ICF) is available. Objective. To examine the content validity of the

  5. FBR core design with the composite fuel assembly

    Energy Technology Data Exchange (ETDEWEB)

    Cappiello, M.W.

    Although calculations are preliminary, overall feasibility of an FBR core design with the composite fuel assembly has been demonstrated. The advantaged over the heterogeneous design is that large variances in assembly mixed mean outlet temperatures are eliminated. Also, the effective enrichment of an assembly may easily be adjusted by varying the number of fertile pins per assembly, thus making it possible to flatten the core radial power profile. The use of the composite fuel assembly may in the future offer a significant alternative to heterogeneous FBR core design.

  6. Core body temperature in obesity123

    Science.gov (United States)

    Heikens, Marc J; Gorbach, Alexander M; Eden, Henry S; Savastano, David M; Chen, Kong Y; Skarulis, Monica C

    2011-01-01

    Background: A lower core body temperature set point has been suggested to be a factor that could potentially predispose humans to develop obesity. Objective: We tested the hypothesis that obese individuals have lower core temperatures than those in normal-weight individuals. Design: In study 1, nonobese [body mass index (BMI; in kg/m2) temperature–sensing capsules, and we measured core temperatures continuously for 24 h. In study 2, normal-weight (BMI of 18–25) and obese subjects swallowed temperature-sensing capsules to measure core temperatures continuously for ≥48 h and kept activity logs. We constructed daily, 24-h core temperature profiles for analysis. Results: Mean (±SE) daily core body temperature did not differ significantly between the 35 nonobese and 46 obese subjects (36.92 ± 0.03°C compared with 36.89 ± 0.03°C; P = 0.44). Core temperature 24-h profiles did not differ significantly between 11 normal-weight and 19 obese subjects (P = 0.274). Women had a mean core body temperature ≈0.23°C greater than that of men (36.99 ± 0.03°C compared with 36.76 ± 0.03°C; P body temperature. It may be necessary to study individuals with function-altering mutations in core temperature–regulating genes to determine whether differences in the core body temperature set point affect the regulation of human body weight. These trials were registered at clinicaltrials.gov as NCT00428987 and NCT00266500. PMID:21367952

  7. 2016 TRI Preliminary Dataset

    Science.gov (United States)

    The TRI preliminary dataset includes the most current TRI data available and reflects toxic chemical releases and pollution prevention activities that occurred at TRI facilities during the 2016 calendar year.

  8. Blue straggler formation at core collapse

    CERN Document Server

    Banerjee, Sambaran

    2016-01-01

    Among the most striking feature of blue straggler stars (BSS) is the presence of multiple sequences of BSSs in the colour-magnitude diagrams (CMDs) of several globular clusters. It is often envisaged that such a multiple BSS sequence would arise due a recent core collapse of the host cluster, triggering a number of stellar collisions and binary mass transfers simultaneously over a brief episode of time. Here we examine this scenario using direct N-body computations of moderately massive star clusters (of order 10^4 Msun ). As a preliminary attempt, these models are initiated with approx. 8-10 Gyr old stellar population and King profiles of high concentrations, being "tuned" to undergo core collapse quickly. BSSs are indeed found to form in a "burst" at the onset of the core collapse and several of such BS-bursts occur during the post-core-collapse phase. In those models that include a few percent primordial binaries, both collisional and binary BSSs form after the onset of the (near) core-collapse. However, t...

  9. The Geoengineering Model Intercomparison Project Phase 6 (GeoMIP6: simulation design and preliminary results

    Directory of Open Access Journals (Sweden)

    B. Kravitz

    2015-06-01

    simulations, and has been expanded to address several further important topics, including key uncertainties in extreme events, the use of geoengineering as part of a portfolio of responses to climate change, and the relatively new idea of cirrus cloud thinning to allow more longwave radiation to escape to space. We discuss experiment designs, as well as the rationale for those designs, showing preliminary results from individual models when available. We also introduce a new feature, called the GeoMIP Testbed, which provides a platform for simulations that will be performed with a few models and subsequently assessed to determine whether the proposed experiment designs will be adopted as core (Tier 1 GeoMIP experiments. This is meant to encourage various stakeholders to propose new targeted experiments that address their key open science questions, with the goal of making GeoMIP more relevant to a broader set of communities.

  10. A Preliminary Real-Time and Realistic Simulation Environment for Percutaneous Coronary Intervention

    Directory of Open Access Journals (Sweden)

    Jianhuang Wu

    2015-01-01

    Full Text Available Percutaneous coronary intervention (PCI is a minimally invasive surgery procedure that is widely used in the treatment of coronary artery disease. This procedure requires interventional cardiologists to have high proficiency and therefore demands an extensive training period in order to ensure successful surgical outcome. In this paper, a realistic and real-time interactive simulator for training PCI procedure is presented. A set of new approaches for core simulation components is devised and integrated into the simulator. Trainees can interact with the virtual simulation environment with real instruments and essential maneuvers encountered in real PCI procedure. Although presently targeted at PCI, our simulator could be easily extended to mimic the necessities of any vascular interventional radiology procedures by updating vascular anatomy. Preliminary validation of the proposed physical model of instruments is conducted on vascular phantom to demonstrate its performance and effectiveness.

  11. Post-depositional changes in snow isotope content: preliminary results of laboratory experiments

    Directory of Open Access Journals (Sweden)

    A. A. Ekaykin

    2009-10-01

    Full Text Available Isotopic content of the snow and firn thickness is assumed to be altered significantly due to the post-depositional (PD mass- and isotope exchange with the atmospheric water vapor. If so, these effects should be accounted for in the ice core-based isotope-temperature paleo-reconstructions. In order to study the intensity of the PD processes we set up a series of laboratory experiments. In this paper we describe in detail the experimental technique and briefly overview preliminary results. It is shown that the PD modifications in the upper layer of snow thickness are noticeably strong even under such a low temperature as −35°C (the value typical for the Central Antarctic summer. It is demonstrated that the PD isotopic changes in snow can be approximated as a linear function of the relative mass loss due to snow sublimation. Possible applications for improving the isotope-temperature paleo-reconstructions are shortly discussed.

  12. 13CO Cores in Taurus Molecular Cloud

    CERN Document Server

    Qian, Lei; Goldsmith, Paul

    2012-01-01

    Young stars form in molecular cores, which are dense condensations within molecular clouds. We have searched for $^{13}$CO $J=1\\to 0$ cores in the Taurus molecular cloud and studied their properties. Our data set has a spatial dynamic range (the ratio of linear map size to the pixel size) of about 1000 and spectrally resolved velocity information. We use empirical fit to the CO and CO$_2$ ice to correct the depletion. The core mass function (CMF) can be fitted better with a log-normal function than with a power law function. We also extract cores and calculate the CMF based on the integrated intensity of $^{13}$CO and the extinction from 2MASS. We demonstrate that there exists core blending, i.e. combined structures that are incoherent in velocity but continuous in column density. The resulting core samples based on 2D and 3D data thus differ significantly from each other. In particular, the cores derived from 2MASS extinction can be fitted with a power-law function, but not a log-normal function. The core ve...

  13. Validation of the International Classification of Functioning,Disability and Health Core Set for patients with organ transplantation in early postoperation stage%国际功能、残疾和健康分类核心要素在器官移植患者术后早期应用中的效度研究

    Institute of Scientific and Technical Information of China (English)

    丁新华; 夏燕萍; 黄晓琳

    2009-01-01

    目的 评估国际功能、残疾和健康分类(ICF)核心要素在器官移植患者术后早期应用中的效度.方法 采用ICF核心要素问卷、功能独立性评测(FIM)以及Barthel指数(BI)评估肾、肝、肺和心脏移植患者,用ICF核心要素的每个目录报告问题的频率评估其内容效度,而用ICF核心要素的目录与FIM和BI的相关性评估其结构效度.结果 共102例器官移植术后早期患者完成研究.在身体功能方面,ICF核心要素中有10个目录作为一个问题被30%以上的患者报告,22个目录与FIM或BI相关.在身体结构中,仅s810(皮肤结构)作为一个问题被30%的患者报告,3个目录与FIM或BI相关.在活动与参与方面,3个目录被30%的患者报告存在问题,15个目录与FIM和BI相关.在环境因素方面,8个目录作为促进因素被30%的患者报告,8个目录与FIM或BI相关.结论 ICF核心要素用于器官移植术后早期患者显示良好的内容效度和结构效度.%Objective To evaluate content validity and construct validity of International Classification of Functioning,Disability and Health(ICF)Core Set for patients with organ transplantation.Methods Patients with kidney,liver,heart,or lung transplantation were assessed with ICF Core Set questionnaire,Functional Independence Measure(FIM)and Barthel Index(BI).Content validity was evaluated with frequency and percentage of patients with a problem for each ICF category,while construct validity was evaluated with Spearman correlation between ICF categories with FIM and BI.Results A consecutive sample of 102 patients completed this study.In body functions,10 categories were reported as a problem by more than 30% of the patients,of which 22 categories correlated significantly with FIM or BI.In body structures,structure areas of skin(s810)were reported as a problem by 30% of the patients,of which 3 categories correlated significantly with FIM or BI.In activities and participation,3 categories were

  14. The core paradox.

    Science.gov (United States)

    Kennedy, G. C.; Higgins, G. H.

    1973-01-01

    Rebuttal of suggestions from various critics attempting to provide an escape from the seeming paradox originated by Higgins and Kennedy's (1971) proposed possibility that the liquid in the outer core was thermally stably stratified and that this stratification might prove a powerful inhibitor to circulation of the outer core fluid of the kind postulated for the generation of the earth's magnetic field. These suggestions are examined and shown to provide no reasonable escape from the core paradox.

  15. K-core inflation

    OpenAIRE

    Alexander L. Wolman

    2011-01-01

    K-core inflation is a new class of underlying inflation measures. The two most popular measures of underlying inflation are core inflation and trimmed mean inflation. The former removes fixed categories of goods and services (food and energy) from the inflation calculation, and the latter removes fixed percentiles of the weighted distribution of price changes. In contrast, k-core inflation specifies a size of relative price change to be removed from the inflation calculation. Thus, the catego...

  16. Safety evaluation of accident-tolerant FCM fueled core with SiC-coated zircalloy cladding for design-basis-accidents and beyond DBAs

    Energy Technology Data Exchange (ETDEWEB)

    Chun, Ji-Han, E-mail: chunjh@kaeri.re.kr; Lim, Sung-Won; Chung, Bub-Dong; Lee, Won-Jae

    2015-08-15

    Highlights: • Thermal conductivity model of the FCM fuel was developed and adopted in the MARS. • Scoping analysis for candidate FCM FAs was performed to select feasible FA. • Preliminary safety criteria for FCM fuel and SiC/Zr cladding were set up. • Enhanced safety margin and accident tolerance for FCM-SiC/Zr core were demonstrated. - Abstract: The FCM fueled cores proposed as an accident tolerant concept is assessed against the design-basis-accident (DBA) and the beyond-DBA (BDBA) scenarios using MARS code. A thermal conductivity model of FCM fuel is incorporated in the MARS code to take into account the effects of irradiation and temperature that was recently measured by ORNL. Preliminary analyses regarding the initial stored energy and accident tolerant performance were carried out for the scoping of various cladding material candidates. A 16 × 16 FA with SiC-coated Zircalloy cladding was selected as the feasible conceptual design through a preliminary scoping analysis. For a selected design, safety analyses for DBA and BDBA scenarios were performed to demonstrate the accident tolerance of the FCM fueled core. A loss of flow accident (LOFA) scenario was selected for a departure-from-nucleate-boiling (DNB) evaluation, and large-break loss of coolant accident (LBLOCA) scenario for peak cladding temperature (PCT) margin evaluation. A control element assembly (CEA) ejection accident scenario was selected for peak fuel enthalpy and temperature. Moreover, a station blackout (SBO) and LBLOCA without a safety injection (SI) scenario were selected as a BDBA. It was demonstrated that the DBA safety margin of the FCM core is satisfied and the time for operator actions for BDBA s is evaluated.

  17. Sediment Core Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — FUNCTION: Provides instrumentation and expertise for physical and geoacoustic characterization of marine sediments. DESCRIPTION: The multisensor core logger measures...

  18. Sediment Core Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — FUNCTION: Provides instrumentation and expertise for physical and geoacoustic characterization of marine sediments.DESCRIPTION: The multisensor core logger measures...

  19. Developing a Research Skill Set

    OpenAIRE

    You, Y. Nancy; Bednarski, Brian

    2014-01-01

    The recent decades have witnessed a significant expansion in the diversity of career paths within academic surgery. Although the skills for providing exemplary surgical care and for maintaining a strong work ethic are the foundations of an academic surgeon, deliberate career planning and organized acquisition of research skills contribute to the success of an academic career. In this article, we identify a set of core academic skills and propose a framework for acquiring them. We also describ...

  20. Developing core interprofessional competencies for community rehabilitation practitioners: findings from an Australian study.

    Science.gov (United States)

    Kendall, E; Muenchberger, H; Catalano, T; Amsters, D; Dorsett, P; Cox, R

    2011-03-01

    This study aimed to determine the core competencies that underpin the practice of community rehabilitation (CR) practitioners working in a single state in Australia. Using a recursive and consultative methodology designed to build consensus, CR professionals, trainers, educators, and researchers developed a preliminary set of core interprofessional competencies that were considered essential to their practice. Data were collected in four main stages that engaged practitioners and experts in the CR field in the process of identifying, defining, validating, and endorsing a set of competencies. The first stage involved focus groups with 50 senior practitioners in metropolitan, rural/remote, regional, and indigenous communities. The second and third stages involved expert panels consisting of 20 trainers/educators, senior leaders, and scholars who refined, defined and validated the competency areas and developed statements that reflected the data.These statements formed the basis of a survey that was distributed to all current CR practitioners based in this state for endorsement, 40 of whom responded. Ten competencies emerged from this process. Although there are limitations to the application of competencies, they will have significant implications for the future training of CR practitioners who can transcend professional boundaries.

  1. Core Forensics: Earth's Accretion and Differentiation

    Science.gov (United States)

    Badro, J.; Brodholt, J. P.; Siebert, J.; Piet, H.; Ryerson, F. J.

    2013-12-01

    Earth's accretion and its primitive differentiation are intimately interlinked processes. One way to constrain accretionary processes is by looking at the major differentiation event that took place during accretion: core formation. Understanding core formation and core composition can certainly shed a new light on early and late accretionary processes. On the other hand, testing certain accretionary models and hypothesis (fluxes, chemistries, timing) allows -short of validating them- at the very least to unambiguously refute them, through the 'filter'' of core formation and composition. Earth's core formed during accretion as a result of melting, phase-separation, and segregation of accretionary building blocks (from meteorites to planetesimals). The bulk composition of the core and mantle depends on the evolution (pressure, temperature, composition) of core extraction during accretion. The entire process left a compositional imprint on both reservoirs: (1) in the silicate Earth, in terms of siderophile trace-element (Ni, Co, V, Cr, among others) concentrations and isotopic fractionation (Si, Cu, among others), a record that is observed in present-day mantle rocks; and (2) on the core, in terms of major element composition and light elements dissolved in the metal, a record that is observed by seismology through the core density-deficit. This imprint constitutes actually a fairly impressive set of evidence (siderophile element concentration and fractionation, volatile and siderophile element isotopic fractionation), can be used today to trace back the primordial processes that occurred 4.5 billion years ago. We are seeking to provide an overhaul of the standard core formation/composition models, by using a new rationale that bridges geophysics and geochemistry. The new ingredients are (1) new laser-heated diamond anvil cell partitioning data, dramatically extending the previous P-T conditions for experimental work, (2) ab initio molecular dynamics calculations to

  2. Core design and optimization of high performance low sodium void 1000 MWe heterogeneous oxide LMFBR cores

    Energy Technology Data Exchange (ETDEWEB)

    Barthold, W.P.; Orechwa, Y.; Su, S.F.; Beitel, J.C.; Turski, R.; Lam, P.S.K.; Fuller, E.L.

    1979-01-01

    Radially heterogeneous core configurations are effective means to reduce sodium void reactivity. In general, radially heterogeneous cores can be designed as tightly or loosely coupled cores with center core or center blanket arrangements. Core height, number of core regions and number of fuel pins per assembly are additional variables in an optimization of basic heterogeneous core configurations. An extensive study was carried out to optimize the core configurations for 1000 MWe LMFBRs. All cores were subject to a common set of nuclear, mechanical, and thermal-hydraulic design assumptions. They were restrained by an upper sodium void reactivity limit of $2.50 and a doubling time of approximately 15 to 18 years. The screening and optimization procedures employed lead to two core layouts which were both tightly coupled. A complete nuclear analysis of these two cores (derived from a loosely coupled configuration/derived from a tightly coupled configuration) determined the fissile inventories (4268.4/4213.4 kg at BOEC), burnups (83.90/100.7 MWd/t peak), reactivity swings (0.49/1.8% ..delta..k total), power and flux distributions for different control insertion patterns, the breeding performance (15.7/15.3 yrs CSDT), the safety parameters, such as sodium void reactivity ($2.38/$2.23 at EOEC), isothermal Doppler coefficients for both sodium-in (45.6/46.1 T dk/dT x 10/sup -4/ core at EOEC) and sodium-out conditions (28.6/28.2 T dk/dT x 10/sup -4/ core at EOEC), and the transient behavior which shows very little space-dependence during a 60 cent reactivity step insertion.

  3. Rough Sets in Approximate Solution Space

    Institute of Scientific and Technical Information of China (English)

    Hui Sun; Wei Tian; Qing Liu

    2006-01-01

    As a new mathematical theory, Rough sets have been applied to processing imprecise, uncertain and in complete data. It has been fruitful in finite and non-empty set. Rough sets, however, are only served as the theoretic tool to discretize the real function. As far as the real function research is concerned, the research to define rough sets in the real function is infrequent. In this paper, we exploit a new method to extend the rough set in normed linear space, in which we establish a rough set,put forward an upper and lower approximation definition, and make a preliminary research on the property of the rough set. A new tool is provided to study the approximation solutions of differential equation and functional variation in normed linear space. This research is significant in that it extends the application of rough sets to a new field.

  4. Antiferromagnetic hedgehogs with superconducting cores

    Energy Technology Data Exchange (ETDEWEB)

    Goldbart, P.M.; Sheehy, D.E. [Department of Physics and Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 (United States)

    1998-09-01

    Excitations of the antiferromagnetic state that resemble antiferromagnetic hedgehogs at large distances but are predominantly superconducting inside a core region are discussed within the context of Zhang{close_quote}s SO(5)-symmetry-based approach to the physics of high-temperature superconducting materials. Nonsingular, in contrast with their hedgehog cousins in pure antiferromagnetism, these texture excitations are what hedgehogs become when the antiferromagnetic order parameter is permitted to {open_quotes}escape{close_quotes} into superconducting directions. The structure of such excitations is determined in a simple setting, and a number of their experimental implications are examined. {copyright} {ital 1998} {ital The American Physical Society}

  5. Dynamico, an Icosahedral Dynamical Core Designed for Consistency and Versatility

    Science.gov (United States)

    Dubos, T.

    2014-12-01

    The design of the icosahedral-hexagonal dynamical core DYNAMICO is presented. DYNAMICO solves the multi-layer rotating shallow-water equations, a compressible variant of the same equivalent to a discretization of the hydrostatic primitive equations (HPE) in a Lagrangian vertical coordinate, and the HPE in a hybrid mass-based vertical coordinate. In line with more general lines of thought known as physics-preserving discretizations and discrete differential geometry, kinematics and dynamics are separated as strictly as possible. This separation means that the transport of mass, scalars and potential temperature uses no information regarding the specific momentum equation being solved. This disregarded information includes the equation of state as well as any metric information, and is used only for certain terms of the momentum budget, written in Hamiltonian, vector-invariant form. The common Hamiltonian structure of the various equations of motion (Tort and Dubos, 2014 ; Dubos and Tort, 2014) is exploited to formulate energy-conserving spatial discretizations in a unified way. Furthermore most of the model code is common to the three sets of equations solved, making it easier to develop and validate each piece of the model separately. This design permits to consider several extensions in the near future, especially to deep-atmosphere, moist and non-hydrostatic equations. Representative academic three-dimensional benchmarks are run and analyzed, showing correctness of the model (Figure : time-zonal statistics from Held and Suarez (1994) simulations). Hopefully preliminary full-physics results will be presented as well. References : T. Dubos and M. Tort, "Equations of atmospheric motion in non-Eulerian vertical coordinates : vector-invariant form and Hamiltonian formulation", accepted by Mon. Wea. Rev. M. Tort and T. Dubos, "Usual approximations to the equations of atmospheric motion : a variational perspective" accepted by J. Atmos. Sci T. Dubos et al., "DYNAMICO

  6. Ice Core Investigations

    Science.gov (United States)

    Krim, Jessica; Brody, Michael

    2008-01-01

    What can glaciers tell us about volcanoes and atmospheric conditions? How does this information relate to our understanding of climate change? Ice Core Investigations is an original and innovative activity that explores these types of questions. It brings together popular science issues such as research, climate change, ice core drilling, and air…

  7. Making an Ice Core.

    Science.gov (United States)

    Kopaska-Merkel, David C.

    1995-01-01

    Explains an activity in which students construct a simulated ice core. Materials required include only a freezer, food coloring, a bottle, and water. This hands-on exercise demonstrates how a glacier is formed, how ice cores are studied, and the nature of precision and accuracy in measurement. Suitable for grades three through eight. (Author/PVD)

  8. Ice Core Investigations

    Science.gov (United States)

    Krim, Jessica; Brody, Michael

    2008-01-01

    What can glaciers tell us about volcanoes and atmospheric conditions? How does this information relate to our understanding of climate change? Ice Core Investigations is an original and innovative activity that explores these types of questions. It brings together popular science issues such as research, climate change, ice core drilling, and air…

  9. Mercury's core evolution

    Science.gov (United States)

    Deproost, Marie-Hélène; Rivoldini, Attilio; Van Hoolst, Tim

    2016-10-01

    Remote sensing data of Mercury's surface by MESSENGER indicate that Mercury formed under reducing conditions. As a consequence, silicon is likely the main light element in the core together with a possible small fraction of sulfur. Compared to sulfur, which does almost not partition into solid iron at Mercury's core conditions and strongly decreases the melting temperature, silicon partitions almost equally well between solid and liquid iron and is not very effective at reducing the melting temperature of iron. Silicon as the major light element constituent instead of sulfur therefore implies a significantly higher core liquidus temperature and a decrease in the vigor of compositional convection generated by the release of light elements upon inner core formation.Due to the immiscibility in liquid Fe-Si-S at low pressure (below 15 GPa), the core might also not be homogeneous and consist of an inner S-poor Fe-Si core below a thinner Si-poor Fe-S layer. Here, we study the consequences of a silicon-rich core and the effect of the blanketing Fe-S layer on the thermal evolution of Mercury's core and on the generation of a magnetic field.

  10. Multiple core computer processor with globally-accessible local memories

    Energy Technology Data Exchange (ETDEWEB)

    Shalf, John; Donofrio, David; Oliker, Leonid

    2016-09-20

    A multi-core computer processor including a plurality of processor cores interconnected in a Network-on-Chip (NoC) architecture, a plurality of caches, each of the plurality of caches being associated with one and only one of the plurality of processor cores, and a plurality of memories, each of the plurality of memories being associated with a different set of at least one of the plurality of processor cores and each of the plurality of memories being configured to be visible in a global memory address space such that the plurality of memories are visible to two or more of the plurality of processor cores.

  11. Mars' core and magnetism.

    Science.gov (United States)

    Stevenson, D J

    2001-07-12

    The detection of strongly magnetized ancient crust on Mars is one of the most surprising outcomes of recent Mars exploration, and provides important insight about the history and nature of the martian core. The iron-rich core probably formed during the hot accretion of Mars approximately 4.5 billion years ago and subsequently cooled at a rate dictated by the overlying mantle. A core dynamo operated much like Earth's current dynamo, but was probably limited in duration to several hundred million years. The early demise of the dynamo could have arisen through a change in the cooling rate of the mantle, or even a switch in convective style that led to mantle heating. Presently, Mars probably has a liquid, conductive outer core and might have a solid inner core like Earth.

  12. Evidence of Historical Supernovae in Ice Cores

    Science.gov (United States)

    Young, Donna

    2011-05-01

    Within the framework of the U.S. Greenland Ice Core Science Project (GISP2), an ice core, known as the GISP H-Core, was collected in June, 1992 adjacent to the GISP2 summit drill site. The project scientists, Gisela A.M. Dreschhoff and Edward J. Zeller, were interested in dating solar proton events with volcanic eruptions. The GISP2-H 122-meter firn and ice core is a record of 415 years of liquid electrical conductivity (LEC) and nitrate concentrations, spanning the years 1992 at the surface through 1577 at the bottom. At the National Ice Core Laboratory in Denver, Colorado, the core (beneath the 12-meter firn) was sliced into 1.5 cm sections and analyzed. The resulting data set consisted of 7,776 individual analyses. The ultrahigh resolution sampling technique resulted in a time resolution of one week near the surface and one month at depth. The liquid electrical conductivity (LEC) sequence contains signals from a number of known volcanic eruptions and provides a dating system at specific locations along the core. The terrestrial and solar background nitrate records show seasonal and annual variations, respectively. However, major nitrate anomalies within the record do not correspond to any known terrestrial or solar events. There is evidence that these nitrate anomalies could be a record of supernovae events. Cosmic X-rays ionize atmospheric nitrogen, producing excess nitrate that is then deposited in the Polar Regions. The GISP2-H ice core has revealed nitrate anomalies at the times of the Tycho and Kepler supernovae. The Cassiopeia A supernova event may be documented in the core as well. We have developed a classroom activity for high school and college students, in which they examine several lines of evidence in the Greenland ice core, discriminating among nearby and mid-latitude volcanic activity, solar proton events, and supernovae. Students infer the date of the Cassiopeia A supernova.

  13. Feasibility of brief ICF core sets for Chinese stroke patients in community-based rehabilitation%中国版简明ICF核心要素量表在社区脑卒中康复中应用的可行性研究

    Institute of Scientific and Technical Information of China (English)

    徐国会; 俞卓伟; 徐悦莹; 郑洁皎

    2011-01-01

    Objective To explore the application and feasibility of brief ICF core sets for Chinese stroke patients in community-based rehabilitation. Method One hundred and forty-six community stroke patients were measured with brief ICF Core Sets for Chinese stroke patients, the NIH Stroke Scale (NIHSS) , Barthel Index (BI) and SF-36. Repetition reliability, internal consistency and face validity were analyzed with Kappa test, Conbach α index and Pearson correlation analysis respectively in the process of PNF technique for six months. Result The brief ICF Core Sets for Chinese stroke patients had very good repetition reliability among components of body function, body structure, activity and participation with Kappa=0.782-0.935 and environment factor with Kappa=0.578-0.931before PNF intervention and with Kappa = 0 .787-0.965 and Kappa = 0.608-0.969 after intervention respectively. Good internal consistency existed in body function , activity and participation and environment factor with α= 0.774-0.926 before PNF intervention and with α= 0.786-0.953 after PNF rehabilitation. There was concurrent validity for the ICF components with BI , NIHSS and SF-36. Correlation coefficient between ICF stroke scales and NIHSS, BI and SF-36 were 0 . 848,0 . 867,0.798 before rehabilitation intervention and 0.854,0 . 879,0 . 832 after PNF intervention respectively . Conclusion Brief ICF core sets evaluation was clinically feasible for stroke community-based rehabilitation with good reliability and validity, and could be further applied and promoted.%目的 探讨中国版脑卒中简明ICF核心要素鼍表(以下简称中国版ICF简表)在社区脑卒中康复中应用的可行性.方法 146例社区脑卒中患者,接受以本体感觉神经肌肉促进疗法(PNF)为主的康复治疗6个月.按照中国版ICF简表、美国国立卫生研究院卒中量表(NIHSS)、Barthel指数(BI)和SF-36的规则进行治疗前后评定.效度研究采用校标效度,以Spearman相关性判

  14. Grain alignment in starless cores

    Energy Technology Data Exchange (ETDEWEB)

    Jones, T. J.; Bagley, M. [Minnesota Institute for Astrophysics, University of Minnesota, Minneapolis, MN 55455 (United States); Krejny, M. [Cree Inc., 4600 Silicon Dr., Durham, NC (United States); Andersson, B.-G. [SOFIA Science Center, USRA, Moffett Field, CA (United States); Bastien, P., E-mail: tjj@astro.umn.edu [Centre de recherche en astrophysique du Québec and Départment de Physique, Université de Montréal, Montréal (Canada)

    2015-01-01

    We present near-IR polarimetry data of background stars shining through a selection of starless cores taken in the K band, probing visual extinctions up to A{sub V}∼48. We find that P{sub K}/τ{sub K} continues to decline with increasing A{sub V} with a power law slope of roughly −0.5. Examination of published submillimeter (submm) polarimetry of starless cores suggests that by A{sub V}≳20 the slope for P versus τ becomes ∼−1, indicating no grain alignment at greater optical depths. Combining these two data sets, we find good evidence that, in the absence of a central illuminating source, the dust grains in dense molecular cloud cores with no internal radiation source cease to become aligned with the local magnetic field at optical depths greater than A{sub V}∼20. A simple model relating the alignment efficiency to the optical depth into the cloud reproduces the observations well.

  15. The t-core of an s-core

    OpenAIRE

    Fayers, Matthew

    2010-01-01

    We consider the $t$-core of an $s$-core partition, when $s$ and $t$ are coprime positive integers. Olsson has shown that the $t$-core of an $s$-core is again an $s$-core, and we examine certain actions of the affine symmetric group on $s$-cores which preserve the $t$-core of an $s$-core. Along the way, we give a new proof of Olsson's result. We also give a new proof of a result of Vandehey, showing that there is a simultaneous $s$- and $t$-core which contains all others.

  16. The t-core of an s-core

    OpenAIRE

    Fayers, Matthew

    2010-01-01

    We consider the $t$-core of an $s$-core partition, when $s$ and $t$ are coprime positive integers. Olsson has shown that the $t$-core of an $s$-core is again an $s$-core, and we examine certain actions of the affine symmetric group on $s$-cores which preserve the $t$-core of an $s$-core. Along the way, we give a new proof of Olsson's result. We also give a new proof of a result of Vandehey, showing that there is a simultaneous $s$- and $t$-core which contains all others.

  17. First combined total reflection X-ray fluorescence and grazing incidence X-ray absorption spectroscopy characterization of aeolian dust archived in Antarctica and Alpine deep ice cores

    Energy Technology Data Exchange (ETDEWEB)

    Cibin, G. [Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxon OX110DE (United Kingdom); IMONT/EIM, Ente Italiano della Montagna, P.za dei Caprettari 70, 00176 Roma (Italy); Universita' degli Studi di Roma Tre, Dipartimento di Scienze Geologiche, L.go S. Leonardo Murialdo 1, 00146 Roma (Italy)], E-mail: giannantonio.cibin@diamond.ac.uk; Marcelli, A. [INFN - Laboratori Nazionali di Frascati, P.O. Box 13, 00044 Frascati (Roma) (Italy); Maggi, V. [Universita degli Studi di Milano-Bicocca, Dipartimento di Scienze dell' Ambiente e del Territorio, Piazza della Scienza 1, 20126 Milano (Italy); Sala, M. [Universita degli Studi di Milano-Bicocca, Dipartimento di Scienze dell' Ambiente e del Territorio, Piazza della Scienza 1, 20126 Milano (Italy); Universita degli Studi di Milano, Dipartimento di Scienze della Terra ' A. Desio' , Sez. Mineralogia, Via Mangiagalli 34, 20133 Milano (Italy); Marino, F.; Delmonte, B. [Universita degli Studi di Milano-Bicocca, Dipartimento di Scienze dell' Ambiente e del Territorio, Piazza della Scienza 1, 20126 Milano (Italy); Albani, S. [Universita degli Studi di Milano-Bicocca, Dipartimento di Scienze dell' Ambiente e del Territorio, Piazza della Scienza 1, 20126 Milano (Italy); Universita degli Studi di Siena, Dottorato in Scienze Polari, via Laterina 8, 53100 Siena (Italy); Pignotti, S. [IMONT/EIM, Ente Italiano della Montagna, P.za dei Caprettari 70, 00176 Roma (Italy)

    2008-12-15

    Aeolian mineral dust archived in polar and mid latitude ice cores represents a precious proxy for assessing environmental and climatic variations at different timescales. In this respect, the identification of dust mineralogy plays a key role. In this work we performed the first preliminary X-ray absorption spectroscopy (XAS) experiments on mineral dust particles extracted from Antarctic and from Alpine firn cores using grazing incidence geometry at the Fe K-edge. A dedicated high vacuum experimental chamber was set up for normal-incidence and total-reflection X-Ray Fluorescence and Absorption Spectroscopy analyses on minor amounts of mineral materials at the Stanford Synchrotron Radiation Laboratory. Results show that this experimental technique and protocol allows recognizing iron inclusion mineral fraction on insoluble dust in the 1-10 {mu}g range.

  18. Tree Coring as a Complement to Soil Gas Screening to Locate PCE and TCE Source Zones and Hot Spots

    DEFF Research Database (Denmark)

    Nielsen, Mette Algreen; Trapp, Stefan; Rehne Jensen, Pernille;

    2015-01-01

    Preliminary risk assessment for prioritisation of site investigations requires efficient screening to reveal type and level of contamination. The screening methods, tree coring and soil gas sampling were applied and compared at two forested sites contaminated with tetrachloroethylene (PCE...

  19. UVISS preliminary visibility analysis

    DEFF Research Database (Denmark)

    Betto, Maurizio

    1998-01-01

    The goal of this work is to obtain a preliminary assessment of the sky visibility for anastronomical telescope located on the express pallet of the International SpaceStation (ISS)} taking into account the major constraints imposed on the instrument by the ISSattitude and structure. Part of the w......The goal of this work is to obtain a preliminary assessment of the sky visibility for anastronomical telescope located on the express pallet of the International SpaceStation (ISS)} taking into account the major constraints imposed on the instrument by the ISSattitude and structure. Part...

  20. Korrelasjon mellom core styrke, core stabilitet og utholdende styrke i core

    OpenAIRE

    Berg-Olsen, Andrea Marie; Fugelsøy, Eivor; Maurstad, Ann-Louise

    2010-01-01

    Formålet med studien var å se hvilke korrelasjon det er mellom core styrke, core stabilitet og utholdende styrke i core. Testingen bestod av tre hoveddeler hvor vi testet core styrke, core stabilitet og utholdende styrke i core. Innenfor core styrke og utholdende styrke i core ble tre ulike tester utført. Ved måling av core stabilitet ble det gjennomført kun en test. I core styrke ble isometrisk abdominal fleksjon, isometrisk rygg ekstensjon og isometrisk lateral fleksjon testet. Sit-ups p...

  1. Korrelasjon mellom core styrke, core stabilitet og utholdende styrke i core

    OpenAIRE

    Berg-Olsen, Andrea Marie; Fugelsøy, Eivor; Maurstad, Ann-Louise

    2010-01-01

    Formålet med studien var å se hvilke korrelasjon det er mellom core styrke, core stabilitet og utholdende styrke i core. Testingen bestod av tre hoveddeler hvor vi testet core styrke, core stabilitet og utholdende styrke i core. Innenfor core styrke og utholdende styrke i core ble tre ulike tester utført. Ved måling av core stabilitet ble det gjennomført kun en test. I core styrke ble isometrisk abdominal fleksjon, isometrisk rygg ekstensjon og isometrisk lateral fleksjon testet. Sit-ups p...

  2. Earth's inner core: Innermost inner core or hemispherical variations?

    NARCIS (Netherlands)

    Lythgoe, K. H.; Deuss, A.; Rudge, J. F.; Neufeld, J. A.

    2014-01-01

    The structure of Earth's deep inner core has important implications for core evolution, since it is thought to be related to the early stages of core formation. Previous studies have suggested that there exists an innermost inner core with distinct anisotropy relative to the rest of the inner core.

  3. Earth's inner core: Innermost inner core or hemispherical variations?

    NARCIS (Netherlands)

    Lythgoe, K. H.; Deuss, A.; Rudge, J. F.; Neufeld, J. A.

    2014-01-01

    The structure of Earth's deep inner core has important implications for core evolution, since it is thought to be related to the early stages of core formation. Previous studies have suggested that there exists an innermost inner core with distinct anisotropy relative to the rest of the inner core.

  4. Extracting the Cores of Implicit Communities

    Institute of Scientific and Technical Information of China (English)

    YANG Nan; LIN Songxiang; GAO Qiang

    2007-01-01

    In this paper, we improve the trawling and point out some communities missed by trawling. We use the DBG (Dense Bipartite Graph) to identify a structure of a potential community instead of CBG (Complete Bipartite Graph). Based on DBG, we proposed a new method based on edge removal to extract cores from a web graph. Moreover, we improve the crawler to save only potential pages as fans of a core and save a lot of disk storage space. To evaluate the set of cores whether or not belong to a community, the statistics of term frequency is used. In the paper,the dataset of experiment were crawled under domain ".cn". The result show that the our algorithm works properly and some new cores can be found by our method.

  5. Dense Molecular Cores Being Externally Heated

    CERN Document Server

    Kim, Gwanjeong; Gopinathan, Maheswar; Jeong, Woong-Seob; Kim, Mi-Ryang

    2016-01-01

    We present results of our study on eight dense cores, previously classified as starless, using infrared (3-160 {\\micron}) imaging observations with \\textit{AKARI} telescope and molecular line (HCN and N$_2$H$^+$) mapping observations with \\textit{KVN} telescope. Combining our results with the archival IR to mm continuum data, we examined the starless nature of these eight cores. Two of the eight cores are found to harbor faint protostars having luminosity of $\\sim0.3-4.4$ L$_{\\odot}$. The other six cores are found to remain as starless and probably are in a dynamically transitional state. The temperature maps produced using multi-wavelength images show an enhancement of about 3-6 K towards the outer boundary of these cores, suggesting that they are most likely being heated externally by nearby stars and/or interstellar radiation fields. Large virial parameters and an over-dominance of red asymmetric line profiles over the cores may indicate that the cores are set into either an expansion or an oscillatory mot...

  6. IGCSE core mathematics

    CERN Document Server

    Wall, Terry

    2013-01-01

    Give your core level students the support and framework they require to get their best grades with this book dedicated to the core level content of the revised syllabus and written specifically to ensure a more appropriate pace. This title has been written for Core content of the revised Cambridge IGCSE Mathematics (0580) syllabus for first teaching from 2013. ? Gives students the practice they require to deepen their understanding through plenty of practice questions. ? Consolidates learning with unique digital resources on the CD, included free with every book. We are working with Cambridge

  7. Core shroud corner joints

    Science.gov (United States)

    Gilmore, Charles B.; Forsyth, David R.

    2013-09-10

    A core shroud is provided, which includes a number of planar members, a number of unitary corners, and a number of subassemblies each comprising a combination of the planar members and the unitary corners. Each unitary corner comprises a unitary extrusion including a first planar portion and a second planar portion disposed perpendicularly with respect to the first planar portion. At least one of the subassemblies comprises a plurality of the unitary corners disposed side-by-side in an alternating opposing relationship. A plurality of the subassemblies can be combined to form a quarter perimeter segment of the core shroud. Four quarter perimeter segments join together to form the core shroud.

  8. Hierarchical Sets: Analyzing Pangenome Structure through Scalable Set Visualizations

    DEFF Research Database (Denmark)

    Pedersen, Thomas Lin

    2017-01-01

    The increase in available microbial genome sequences has resulted in an increase in the size of the pangenomes being analyzed. Current pangenome visualizations are not intended for the pangenome sizes possible today and new approaches are necessary in order to convert the increase in available...... information to increase in knowledge. As the pangenome data structure is essentially a collection of sets we explore the potential for scalable set visualization as a tool for pangenome analysis. We present a new hierarchical clustering algorithm based on set arithmetics that optimizes the intersection sizes...... along the branches. The intersection and union sizes along the hierarchy are visualized using a composite dendrogram and icicle plot, which, in pangenome context, shows the evolution of pangenome and core size along the evolutionary hierarchy. Outlying elements, i.e. elements whose presence pattern do...

  9. Core Competencies for Training Effective School Consultants

    Science.gov (United States)

    Burkhouse, Katie Lynn Sutton

    2012-01-01

    The purpose of this research was to develop and validate a set of core competencies of effective school-based consultants for preservice school psychology consultation training. With recent changes in service delivery models, psychologists are challenged to engage in more indirect, preventative practices (Reschly, 2008). Consultation emerges as…

  10. Core Competencies for Training Effective School Consultants

    Science.gov (United States)

    Burkhouse, Katie Lynn Sutton

    2012-01-01

    The purpose of this research was to develop and validate a set of core competencies of effective school-based consultants for preservice school psychology consultation training. With recent changes in service delivery models, psychologists are challenged to engage in more indirect, preventative practices (Reschly, 2008). Consultation emerges as…

  11. UVISS preliminary visibility analysis

    DEFF Research Database (Denmark)

    Betto, Maurizio

    1998-01-01

    The goal of this work is to obtain a preliminary assessment of the sky visibility for anastronomical telescope located on the express pallet of the International SpaceStation (ISS)} taking into account the major constraints imposed on the instrument by the ISSattitude and structure. Part...

  12. Biospecimen Core Resource - TCGA

    Science.gov (United States)

    The Cancer Genome Atlas (TCGA) Biospecimen Core Resource centralized laboratory reviews and processes blood and tissue samples and their associated data using optimized standard operating procedures for the entire TCGA Research Network.

  13. NICHD Zebrafish Core

    Data.gov (United States)

    Federal Laboratory Consortium — The core[HTML_REMOVED]s goal is to help researchers of any expertise perform zebrafish experiments aimed at illuminating basic biology and human disease mechanisms,...

  14. iPSC Core

    Data.gov (United States)

    Federal Laboratory Consortium — The induced Pluripotent Stem Cells (iPSC) Core was created in 2011 to accelerate stem cell research in the NHLBI by providing investigators consultation, technical...

  15. Reference: -300CORE [PLACE

    Lifescience Database Archive (English)

    Full Text Available -300CORE Forde BG, Heyworth A, Pywell J, Kreis M Nucleotide sequence of a B1 hordein gene and the identifica...tion of possible upstream regulatory elements in endosperm storage protein genes fr

  16. INTEGRAL core programme

    Science.gov (United States)

    Gehrels, N.; Schoenfelder, V.; Ubertini, P.; Winkler, C.

    1997-01-01

    The International Gamma Ray Astrophysics Laboratory (INTEGRAL) mission is described with emphasis on the INTEGRAL core program. The progress made in the planning activities for the core program is reported on. The INTEGRAL mission has a nominal lifetime of two years with a five year extension option. The observing time will be divided between the core program (between 30 and 35 percent during the first two years) and general observations. The core program consists of three main elements: the deep survey of the Galactic plane in the central radian of the Galaxy; frequent scans of the Galactic plane in the search for transient sources, and pointed observations of several selected sources. The allocation of the observation time is detailed and the sensitivities of the observations are outlined.

  17. Focusing on Core Business

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    China is regulating state-owned enterprises that are investing outside of their core business realms, concerned that poor investment decisions could lead to loss of state-owned assets, but some doubt the effect of the new regulation

  18. Organizing Core Tasks

    DEFF Research Database (Denmark)

    Boll, Karen

    Civil servants conduct the work which makes welfare states functions on an everyday bases: Police men police, school teachers teach, and tax inspectors inspect. Focus in this paper is on the core tasks of tax inspectors. The paper argues that their core task of securing the collection of revenue...... has remained much the same within the last 10 years. However, how the core task has been organized has changed considerable under the influence of various “organizing devices”. The paper focusses on how organizing devices such as risk assessment, output-focus, effect orientation, and treatment...... projects influence the organization of core tasks within the tax administration. The paper shows that the organizational transformations based on the use of these devices have had consequences both for the overall collection of revenue and for the employees’ feeling of “making a difference”. All in all...

  19. Preliminary Results on Lunar Interior Properties from the GRAIL Mission

    Science.gov (United States)

    Williams, James G.; Konopliv, Alexander S.; Asmar, Sami W.; Lemoine, H. Jay; Melosh, H. Jay; Neumann, Gregory A.; Phillips, Roger J.; Smith, David E.; Solomon, Sean C.; Watkins, Michael M.; Wieczorek, Mark A.; Zuber, Maria T.; Andrews-Hanna, Jeffrey C.; Head, James W.; Kiefer, Walter S.; Matsuyama, Isamu; McGovern, Patrick J.; Nimmo, Francis; Weber, Renee C.; Boggs, D. H.; Goossens, Sander J.; Kruizinga, Gerhard L.; Mazarico, Erwan; Park, Ryan S.; Yuan, Dah-Ning

    2013-01-01

    The Gravity Recovery and Interior Laboratory (GRAIL) mission has provided lunar gravity with unprecedented accuracy and resolution. GRAIL has produced a high-resolution map of the lunar gravity field while also determining tidal response. We present the latest gravity field solution and its preliminary implications for the Moon's interior structure, exploring properties such as the mean density, moment of inertia of the solid Moon, and tidal potential Love number k2. Lunar structure includes a thin crust, a deep mantle, a fluid core, and a suspected solid inner core. An accurate Love number mainly improves knowledge of the fluid core and deep mantle. In the future GRAIL will search for evidence of tidal dissipation and a solid inner core.

  20. The AGB bump: a calibrator for the core mixing

    CERN Document Server

    Bossini, Diego; Salaris, Maurizio; Girardi, Léo; Montalbán, Josefina; Bressan, Alessandro; Marigo, Paola; Noels, Arlette

    2015-01-01

    The efficiency of convection in stars affects many aspects of their evolution and remains one of the key-open questions in stellar modelling. In particular, the size of the mixed core in core-He-burning low-mass stars is still uncertain and impacts the lifetime of this evolutionary phase and, e.g., the C/O profile in white dwarfs. One of the known observables related to the Horizontal Branch (HB) and Asymptotic Giant Branch (AGB) evolution is the AGB bump. Its luminosity depends on the position in mass of the helium-burning shell at its first ignition, that is affected by the extension of the central mixed region. In this preliminary work we show how various assumptions on near-core mixing and on the thermal stratification in the overshooting region affect the luminosity of the AGB bump, as well as the period spacing of gravity modes in core-He-burning models.

  1. The AGB bump: a calibrator for core mixing

    Science.gov (United States)

    Bossini, Diego; Miglio, Andrea; Salaris, Maurizio; Girardi, Léo; Montalbán, Josefina; Bressan, Alessandro; Marigo, Paola; Noels, Arlette

    2015-09-01

    The efficiency of convection in stars affects many aspects of their evolution and remains one of the key-open questions in stellar modelling. In particular, the size of the mixed core in core-He-burning low-mass stars is still uncertain and impacts the lifetime of this evolutionary phase and, e.g., the C/O profile in white dwarfs. One of the known observables related to the Horizontal Branch (HB) and Asymptotic Giant Branch (AGB) evolution is the AGB bump. Its luminosity depends on the position in mass of the helium-burning shell at its first ignition, that is affected by the extension of the central mixed region. In this preliminary work we show how various assumptions on near-core mixing and on the thermal stratification in the overshooting region affect the luminosity of the AGB bump, as well as the period spacing of gravity modes in core-He-burning models.

  2. The AGB bump: a calibrator for core mixing

    Directory of Open Access Journals (Sweden)

    Bossini Diego

    2015-01-01

    Full Text Available The efficiency of convection in stars affects many aspects of their evolution and remains one of the key-open questions in stellar modelling. In particular, the size of the mixed core in core-He-burning low-mass stars is still uncertain and impacts the lifetime of this evolutionary phase and, e.g., the C/O profile in white dwarfs. One of the known observables related to the Horizontal Branch (HB and Asymptotic Giant Branch (AGB evolution is the AGB bump. Its luminosity depends on the position in mass of the helium-burning shell at its first ignition, that is affected by the extension of the central mixed region. In this preliminary work we show how various assumptions on near-core mixing and on the thermal stratification in the overshooting region affect the luminosity of the AGB bump, as well as the period spacing of gravity modes in core-He-burning models.

  3. Structure and dynamics of core-periphery networks

    CERN Document Server

    Csermely, Peter; Wu, Ling-Yun; Uzzi, Brian

    2013-01-01

    Recent studies uncovered important core/periphery network structures characterizing complex sets of cooperative and competitive interactions between network nodes, be they proteins, cells, species or humans. Better characterization of the structure, dynamics and function of core/periphery networks is a key step of our understanding cellular functions, species adaptation, social and market changes. Here we summarize the current knowledge of the structure and dynamics of "traditional" core/periphery networks, rich-clubs, nested, bow-tie and onion networks. Comparing core/periphery structures with network modules, we discriminate between global and local cores. The core/periphery network organization lies in the middle of several extreme properties, such as random/condensed structures, clique/star configurations, network symmetry/asymmetry, network assortativity/disassortativity, as well as network hierarchy/anti-hierarchy. These properties of high complexity together with the large degeneracy of core pathways e...

  4. Setting a personal career direction.

    Science.gov (United States)

    McCurdy, Fredrick A; Marcdante, Karen

    2003-01-01

    In summary, we believe that both you and your organization should have a set of core values, a well-defined mission (core purpose), and a vision of the future. Ideally, your projects and activities should be congruent with your mission and values, you should be pursuing your vision, and all of this should be congruent with the organization mission and values. Practically speaking, most individuals we have worked with over the years find themselves in two different groups at this point in the exercise. The minority find that their personal mission is not at all similar to the mission of their current organization and they find it necessary to seriously reevaluate their personal career direction. Sometimes, this results in them finding some other place to work. On the other hand, the majority discover their personal mission is in reasonable agreement with that of their organization. For both, this exercise has helped them clarify and better manage their personal career direction.

  5. Preliminary results of the XR2-1 experiment

    Energy Technology Data Exchange (ETDEWEB)

    Gauntt, R.O.; Helmick, P.H. [Sandia National Labs., Albuquerque, NM (United States); Humphries, L. [SAIC, Albuquerque, NM (United States)

    1996-03-01

    The XR2-1 (Ex-Reactor) experiment, investigating metallic core-melt relocation in boiling water reactor geometry, was performed on October 12, 1995, following two previous simpler XR1-series tests in August and November of 1993. The XR2-1 test made use of a highly detailed replication of the lower region of the BWR core, including the control blade and channel box structures, fuel rods, fuel canister nosepieces, control blade velocity limiter, and fuel support pieces, in order to investigate a key core melt progression uncertainty for BWR Station Blackout type accidents. The purpose of this experiment program is to examine the behavior of downward-draining molten metallic core materials in a severe reactor accident in a dry BWR core, and to determine conditions under which the molten materials drain out of the core region, or freeze to form blockages in the lower portion of the core. In the event that the draining metallic materials do not form stable blockages in the lower core region, and instead erode the lower core structures such as the lower core plate, then the subsequent core melt progression processes may proceed quite differently than was observed in the TMI-2 accident, with correspondingly different impact on vessel loading and vessel release behavior. The results of the Ex-Reactor tests are preliminary. All of the tests conducted have shown a significant degree of channel box destruction induced by the draining control blade materials. The XR2-1 test further showed that the draining zircaloy melt causes significant disruption of the fuel rod geometry. All of the tests have shown tendencies to form interim blockages as the melts temporarily freeze, but that these blockages re-melt, assisted by eutectic interactions, resulting in the sudden draining of accumulated metallic melt pools.

  6. Simulating an Exploding Fission-Bomb Core

    Science.gov (United States)

    Reed, Cameron

    2016-03-01

    A time-dependent desktop-computer simulation of the core of an exploding fission bomb (nuclear weapon) has been developed. The simulation models a core comprising a mixture of two isotopes: a fissile one (such as U-235) and an inert one (such as U-238) that captures neutrons and removes them from circulation. The user sets the enrichment percentage and scattering and fission cross-sections of the fissile isotope, the capture cross-section of the inert isotope, the number of neutrons liberated per fission, the number of ``initiator'' neutrons, the radius of the core, and the neutron-reflection efficiency of a surrounding tamper. The simulation, which is predicated on ordinary kinematics, follows the three-dimensional motions and fates of neutrons as they travel through the core. Limitations of time and computer memory render it impossible to model a real-life core, but results of numerous runs clearly demonstrate the existence of a critical mass for a given set of parameters and the dramatic effects of enrichment and tamper efficiency on the growth (or decay) of the neutron population. The logic of the simulation will be described and results of typical runs will be presented and discussed.

  7. Typing a Core Binary Field Arithmetic in a Light Logic

    OpenAIRE

    Cesena, Emanuele; Pedicini, Marco; Roversi, Luca

    2011-01-01

    We design a library for binary field arithmetic and we supply a core API which is completely developed in DLAL, extended with a fix point formula. Since DLAL is a restriction of linear logic where only functional programs with polynomial evaluation cost can be typed, we obtain the core of a functional programming setting for binary field arithmetic with built-in polynomial complexity.

  8. The American Kinesiology Association Undergraduate Core Curriculum©

    Science.gov (United States)

    Chodzko-Zajko, Wojtek

    2014-01-01

    This article describes the elements of the undergraduate core in kinesiology that have been established by the American Kinesiology Association. The American Kinesiology Association also describes a set of ten student-learning outcomes that emanate from the four core content elements. This information has been developed by the American Kinesiology…

  9. Size monotonicity and stability of the core in hedonic games

    OpenAIRE

    Dimitrov, Dinko; Sung, Shao Chin

    2011-01-01

    We show that the core of each strongly size monotonic hedonic game is not empty and is externally stable. This is in sharp contrast to other sufficient conditions for core non-emptiness which do not even guarantee the existence of a stable set in such games.

  10. In Search of Introductory Psychology's Classic Core Vocabulary.

    Science.gov (United States)

    Griggs, Richard A.; Mitchell, Montserrat C.

    2002-01-01

    Examines whether there was a common vocabulary present within introductory psychology textbooks during the 1950s and if a classic core vocabulary exists. Reports that no common core existed in the textbooks during the 1950s, but there is a set of 100 classic vocabulary terms. (CMK)

  11. The American Kinesiology Association Undergraduate Core Curriculum©

    Science.gov (United States)

    Chodzko-Zajko, Wojtek

    2014-01-01

    This article describes the elements of the undergraduate core in kinesiology that have been established by the American Kinesiology Association. The American Kinesiology Association also describes a set of ten student-learning outcomes that emanate from the four core content elements. This information has been developed by the American Kinesiology…

  12. Packing in protein cores

    Science.gov (United States)

    Gaines, J. C.; Clark, A. H.; Regan, L.; O'Hern, C. S.

    2017-07-01

    Proteins are biological polymers that underlie all cellular functions. The first high-resolution protein structures were determined by x-ray crystallography in the 1960s. Since then, there has been continued interest in understanding and predicting protein structure and stability. It is well-established that a large contribution to protein stability originates from the sequestration from solvent of hydrophobic residues in the protein core. How are such hydrophobic residues arranged in the core; how can one best model the packing of these residues, and are residues loosely packed with multiple allowed side chain conformations or densely packed with a single allowed side chain conformation? Here we show that to properly model the packing of residues in protein cores it is essential that amino acids are represented by appropriately calibrated atom sizes, and that hydrogen atoms are explicitly included. We show that protein cores possess a packing fraction of φ ≈ 0.56 , which is significantly less than the typically quoted value of 0.74 obtained using the extended atom representation. We also compare the results for the packing of amino acids in protein cores to results obtained for jammed packings from discrete element simulations of spheres, elongated particles, and composite particles with bumpy surfaces. We show that amino acids in protein cores pack as densely as disordered jammed packings of particles with similar values for the aspect ratio and bumpiness as found for amino acids. Knowing the structural properties of protein cores is of both fundamental and practical importance. Practically, it enables the assessment of changes in the structure and stability of proteins arising from amino acid mutations (such as those identified as a result of the massive human genome sequencing efforts) and the design of new folded, stable proteins and protein-protein interactions with tunable specificity and affinity.

  13. Subannual layer variability in Greenland firn cores

    Science.gov (United States)

    Kjær, Helle Astrid; Vallelonga, Paul; Vinther, Bo; Winstrup, Mai; Simonsen, Marius; Maffezzoli, Niccoló; Jensen, Camilla Marie

    2017-04-01

    Ice cores are used to infer information about the past and modern techniques allow for high resolution (CFA) of the ice. Such analysis is often used to inform on annual layers to constrain dating of ice cores, but can also be extended to provide information on sub-annual deposition patterns. In this study we use available high resolution data from multiple shallow cores around Greenland to investigate the seasonality and trends in the most often continuously measured components sodium, insoluble dust, calcium, ammonium and conductivity (or acidity) from 1800 AD to today. We evaluate the similarities and differences between the records and discuss the causes from different sources and transport to deposition and post-deposition effects over differences in measurement set up. Further we add to the array of cores already published with measurements from the newly drilled ReCAP ice core from a coastal ice cap in eastern Greenland and from a shallow core drilled at the high accumulation site at the Greenland South Dome.

  14. Cool Core Disruption in Abell 1763

    Science.gov (United States)

    Douglass, Edmund; Blanton, Elizabeth L.; Clarke, Tracy E.; Randall, Scott W.; Edwards, Louise O. V.; Sabry, Ziad

    2017-01-01

    We present the analysis of a 20 ksec Chandra archival observation of the massive galaxy cluster Abell 1763. A model-subtracted image highlighting excess cluster emission reveals a large spiral structure winding outward from the core to a radius of ~950 kpc. We measure the gas of the inner spiral to have significantly lower entropy than non-spiral regions at the same radius. This is consistent with the structure resulting from merger-induced motion of the cluster’s cool core, a phenomenon seen in many systems. Atypical of spiral-hosting clusters, an intact cool core is not detected. Its absence suggests the system has experienced significant disruption since the initial dynamical encounter that set the sloshing core in motion. Along the major axis of the elongated ICM distribution we detect thermal features consistent with the merger event most likely responsible for cool core disruption. The merger-induced transition towards non-cool core status will be discussed. The interaction between the powerful (P1.4 ~ 1026 W Hz-1) cluster-center WAT radio source and its ICM environment will also be discussed.

  15. Palaeointensity, core thermal conductivity and the unknown age of the inner core

    Science.gov (United States)

    Smirnov, Aleksey V.; Tarduno, John A.; Kulakov, Evgeniy V.; McEnroe, Suzanne A.; Bono, Richard K.

    2016-05-01

    Data on the evolution of Earth's magnetic field intensity are important for understanding the geodynamo and planetary evolution. However, the paleomagnetic record in rocks may be adversely affected by many physical processes, which must be taken into account when analysing the palaeointensity database. This is especially important in the light of an ongoing debate regarding core thermal conductivity values, and how these relate to the Precambrian geodynamo. Here, we demonstrate that several data sets in the Precambrian palaeointensity database overestimate the true paleofield strength due to the presence of non-ideal carriers of palaeointensity signals and/or viscous re-magnetizations. When the palaeointensity overestimates are removed, the Precambrian database does not indicate a robust change in geomagnetic field intensity during the Mesoproterozoic. These findings call into question the recent claim that the solid inner core formed in the Mesoproterozoic, hence constraining the thermal conductivity in the core to `moderate' values. Instead, our analyses indicate that the presently available palaeointensity data are insufficient in number and quality to constrain the timing of solid inner core formation, or the outstanding problem of core thermal conductivity. Very young or very old inner core ages (and attendant high or low core thermal conductivity values) are consistent with the presently known history of Earth's field strength. More promising available data sets that reflect long-term core structure are geomagnetic reversal rate and field morphology. The latter suggests changes that may reflect differences in Archean to Proterozoic core stratification, whereas the former suggest an interval of geodynamo hyperactivity at ca. 550 Ma.

  16. Planktonic foraminifera from core tops of western equatorial Indian Ocean

    Digital Repository Service at National Institute of Oceanography (India)

    Naidu, P.D.; Guptha, M.V.S.

    A set of seven core tops from western equatorial Indian ocean were analysed for planktonic foraminifera, which has yielded 20 planktonic foraminiferal species. Among them Globorotalia menardii, Globigerinoides sacculifer and G. ruber constitute...

  17. Sediment core data from offshore Palos Verdes, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The seven files included in this U.S. Geological Survey data release are data from a set of sediment cores acquired from the continental slope, offshore Los Angeles...

  18. Sediment core data from offshore Palos Verdes, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — TThe seven files included in this U.S. Geological Survey data release are data from a set of sediment cores acquired from the continental slope, offshore Los Angeles...

  19. Is There a Core Vocabulary? Some Implications for Language Teaching.

    Science.gov (United States)

    Carter, Ronald

    1987-01-01

    Describes a set of criteria for selection of core vocabulary, with examples given from English. Suggests applications for such a vocabulary in grading reading materials and analyzing stylistics. (LMO)

  20. Inner core structure behind the PKP core phase triplication

    NARCIS (Netherlands)

    Blom, Nienke A.; Deuss, Arwen; Paulssen, Hanneke; Waszek, Lauren

    2015-01-01

    The structure of the Earth's inner core is not well known between depths of ∼100–200 km beneath the inner core boundary. This is a result of the PKP core phase triplication and the existence of strong precursors to PKP phases, which hinder the measurement of inner core compressional PKIKP waves at e

  1. Inner core structure behind the PKP core phase triplication

    NARCIS (Netherlands)

    Blom, Nienke A.; Deuss, Arwen; Paulssen, Hanneke; Waszek, Lauren

    The structure of the Earth's inner core is not well known between depths of ∼100–200 km beneath the inner core boundary. This is a result of the PKP core phase triplication and the existence of strong precursors to PKP phases, which hinder the measurement of inner core compressional PKIKP waves at

  2. Pressure Core Characterization

    Science.gov (United States)

    Santamarina, J. C.

    2014-12-01

    Natural gas hydrates form under high fluid pressure and low temperature, and are found in permafrost, deep lakes or ocean sediments. Hydrate dissociation by depressurization and/or heating is accompanied by a multifold hydrate volume expansion and host sediments with low permeability experience massive destructuration. Proper characterization requires coring, recovery, manipulation and testing under P-T conditions within the stability field. Pressure core technology allows for the reliable characterization of hydrate bearing sediments within the stability field in order to address scientific and engineering needs, including the measurement of parameters used in hydro-thermo-mechanical analyses, and the monitoring of hydrate dissociation under controlled pressure, temperature, effective stress and chemical conditions. Inherent sampling effects remain and need to be addressed in test protocols and data interpretation. Pressure core technology has been deployed to study hydrate bearing sediments at several locations around the world. In addition to pressure core testing, a comprehensive characterization program should include sediment analysis, testing of reconstituted specimens (with and without synthetic hydrate), and in situ testing. Pressure core characterization technology can be used to study other gas-charged formations such as deep sea sediments, coal bed methane and gas shales.

  3. On Preliminary Breakdown

    Science.gov (United States)

    Beasley, W. H.; Petersen, D.

    2013-12-01

    The preliminary breakdown phase of a negative cloud-to-ground lightning flash was observed in detail. Observations were made with a Photron SA1.1 high-speed video camera operating at 9,000 frames per second, fast optical sensors, a flat-plate electric field antenna covering the SLF to MF band, and VHF and UHF radio receivers with bandwidths of 20 MHz. Bright stepwise extensions of a negative leader were observed at an altitude of 8 km during the first few milliseconds of the flash, and were coincident with bipolar electric field pulses called 'characteristic pulses'. The 2-D step lengths of the preliminary processes were in excess of 100 meters, with some 2-D step lengths in excess of 200 meters. Smaller and shorter unipolar electric field pulses were superposed onto the bipolar electric field pulses, and were coincident with VHF and UHF radio pulses. After a few milliseconds, the emerging negative stepped leader system showed a marked decrease in luminosity, step length, and propagation velocity. Details of these events will be discussed, including the possibility that the preliminary breakdown phase consists not of a single developing lightning leader system, but of multiple smaller lightning leader systems that eventually join together into a single system.

  4. Core-polarization effects in Cu II

    Energy Technology Data Exchange (ETDEWEB)

    Biemont, E. [Liege Univ. (Belgium). Inst. de Phys. Nucl. Exp.; Astrophysique et Spectroscopie, Univ. de Mons, Mons (Belgium); Pinnington, E.H. [Alberta Univ., Edmonton, AB (Canada). Dept. of Physics; Quinet, P. [Astrophysique et Spectroscopie, Univ. de Mons, Mons (Belgium); Zeippen, C.J. [Observatoire de Paris, Section de Meudon, 92 (France). DAEC

    2000-05-01

    Core-polarization and configuration interaction effects are investigated in singly ionized copper. It is shown that these effects are responsible, to a large extent, for the discrepancies observed between recent relativistic Hartree-Fock (HFR) and configuration-interaction (CIV3) calculations and accurate beam-laser experimental results. A new set of transition rates is obtained using the HFR + core polarization formalism leading to theoretical lifetime and transition probability values in fair agreement with the experiment. An indicative calculation performed with the configuration-interaction code superstructure demonstrates the importance of semi-empirical term energy corrections in producing reliable transition ratesin a case like the present one. (orig.)

  5. Test of the hadronic interaction models at around *10 TeV with Tibet EAS core data

    CERN Document Server

    ,

    2013-01-01

    A hybrid experiment has been started by AS{\\gamma} collaboration at Tibet, China, since May 2009, that consists of a burst-detector-grid (YAC, Yangbajing Air shower Core array) and the Tibet air-shower array (Tibet-III). The first step of YAC, called YAC-I, contains 16 detector units and observes high energy electromagnetic particles in air-shower cores within several meters from the shower axis, and Tibet-III array measures the total energy and the arrival direction of air showers. YAC-I is used to check hadronic interaction models currently used for air-shower simulations such as QGSJET, SIBYLL, EPOS etc. through the multi-parameter measurement in air-shower cores. In this paper, we used a data set collected from May 1st 2009 through February 23rd 2010 by the YAC-I. The effective live time used for the present analysis is 169.65 days. The preliminary results of the interaction model checking at *10 TeV energy region is reported in this paper.

  6. 应用肥胖国际功能、失能和健康分类综合核心组合描述肥胖型多囊卵巢综合征的疾病特征%Disease characteristics of obese patients with polycystic ovary syndrome described by the obesity component of the International Classification of Functioning, Disability and Health comprehensive core set

    Institute of Scientific and Technical Information of China (English)

    王萍; 江钟立; 林枫; 张勤

    2015-01-01

    目的 使用肥胖ICF综合核心组合对肥胖型多囊卵巢综合征(PCOS)的疾病特征进行描述,揭示和探讨符合肥胖型PCOS疾病特征功能障碍的相关领域.方法 使用肥胖ICF综合核心组合对60例肥胖型PCOS患者进行评估,大于30%的患者报告作为障碍的条目才被考虑与PCOS患者的功能相关.结果 参与研究的60例肥胖型PCOS患者中,肥胖ICF综合核心组合条目的109条中有20个条目被选择与PCOS疾病特征相关.其中,身体功能领域有6条(占全部被选择条目的30%),身体结构领域有1条(占全部被选择条目的5%),环境因素领域有13条(占全部被选择条目的65%).结论 肥胖ICF综合核心组合可用于描述肥胖型PCOS的疾病特征和功能障碍,为临床应用ICF核心组合评估PCOS患者的功能障碍提供了可能.%Objective To describe the disease characteristics of obese patients with polycystic ovary syndrome (PCOS) using the obesity core set of the obesity International Classification of Functioning,Disability and Health (ICF) to reveal the related dysfunction domains.Methods Sixty obese patients with PCOS were evaluated by using the ICF's obesity comprehensive core set.Categories reported as a problem by at least 30% of the patients were considered as a relevant functional profile for PCOS patients.Results In obese 60 patients with PCOS,20 items were selected from 109 items of obesity ICF comprehensive core set and considered as the relevant functional characteristics for PCOS among the obese,in which 6 items of body functions (30% of all selected items),1 item of body structures (5% of all selected items),and 13 items of environmental factors (65% of all selected items) were included.Conclusions The obesity core set of the ICF can be applied to describe the disease characteristics and dysfunction of obese patients with PCOS,which offers the possibility of clinic application of the ICF core set for PCOS.

  7. 44Ti and 56Ni in core-collapse supernovae

    CERN Document Server

    Magkotsios, Georgios; Wiescher, Michael; Fryer, Christopher L; Hungerford, Aimee; Young, Patrick; Bennett, Michael; Diehl, Steven; Herwig, Falk; Hirschi, Raphael; Pignatari, Marco; Rockefeller, Gabriel

    2008-01-01

    We investigate the physical conditions where 44Ti and 56Ni are created in core-collapse supernovae. In this preliminary work we use a series of post-processing network calculations with parametrized expansion profiles that are representative of the wide range of temperatures, densities and electron-to-baryon ratios found in 3D supernova simulations. Critical flows that affect the final yields of 44Ti and 56Ni are assessed.

  8. New radiofrequency device to reduce bleeding after core needle biopsy: Experimental study in a porcine liver model

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Sang Hyeok; Rhim, Hyun Chul; Lee, Min Woo; Song, Kyoung Doo; Kang, Tae Wook; Kim, Young Sun; Lim, Hyo Keun [Dept. of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2017-01-15

    To evaluate the in vivo efficiency of the biopsy tract radiofrequency ablation for hemostasis after core biopsy of the liver in a porcine liver model, including situations with bleeding tendency and a larger (16-gauge) core needle. A preliminary study was performed using one pig to determine optimal ablation parameters. For the main experiment, four pigs were assigned to different groups according to heparinization use and biopsy needle caliber. In each pig, 14 control (without tract ablation) and 14 experimental (tract ablation) ultrasound-guided core biopsies were performed using either an 18- or 16-gauge needle. Post-biopsy bleeding amounts were measured by soaking up the blood for five minutes. The results were compared using the Mann-Whitney U test. The optimal parameters for biopsy tract ablation were determined as a 2-cm active tip electrode set at 40-watt with a tip temperature of 70–80℃. The bleeding amounts in all experimental groups were smaller than those in the controls; however they were significant in the non-heparinized pig biopsied with an 18-gauge needle and in two heparinized pigs (p < 0.001). In the heparinized pigs, the mean blood loss in the experimental group was 3.5% and 13.5% of the controls biopsied with an 18- and 16-gauge needle, respectively. Radiofrequency ablation of hepatic core biopsy tract ablation may reduce post-biopsy bleeding even under bleeding tendency and using a larger core needle, according to the result from in vivo porcine model experiments.

  9. New Radiofrequency Device to Reduce Bleeding after Core Needle Biopsy: Experimental Study in a Porcine Liver Model

    Science.gov (United States)

    Lim, Sanghyeok; Lee, Min Woo; Song, Kyoung Doo; Kang, Tae Wook; Kim, Young-sun; Lim, Hyo Keun

    2017-01-01

    Objective To evaluate the in vivo efficiency of the biopsy tract radiofrequency ablation for hemostasis after core biopsy of the liver in a porcine liver model, including situations with bleeding tendency and a larger (16-gauge) core needle. Materials and Methods A preliminary study was performed using one pig to determine optimal ablation parameters. For the main experiment, four pigs were assigned to different groups according to heparinization use and biopsy needle caliber. In each pig, 14 control (without tract ablation) and 14 experimental (tract ablation) ultrasound-guided core biopsies were performed using either an 18- or 16-gauge needle. Post-biopsy bleeding amounts were measured by soaking up the blood for five minutes. The results were compared using the Mann-Whitney U test. Results The optimal parameters for biopsy tract ablation were determined as a 2-cm active tip electrode set at 40-watt with a tip temperature of 70–80℃. The bleeding amounts in all experimental groups were smaller than those in the controls; however they were significant in the non-heparinized pig biopsied with an 18-gauge needle and in two heparinized pigs (p < 0.001). In the heparinized pigs, the mean blood loss in the experimental group was 3.5% and 13.5% of the controls biopsied with an 18- and 16-gauge needle, respectively. Conclusion Radiofrequency ablation of hepatic core biopsy tract ablation may reduce post-biopsy bleeding even under bleeding tendency and using a larger core needle, according to the result from in vivo porcine model experiments. PMID:28096727

  10. Hollow-core photonic crystal fiber-optic probes for Raman spectroscopy.

    Science.gov (United States)

    Konorov, Stanislav O; Addison, Christopher J; Schulze, H Georg; Turner, Robin F B; Blades, Michael W

    2006-06-15

    We have implemented a new Raman fiber-optic probe design based on a hollow-core photonic-crystal excitation fiber surrounded by silica-core collection fibers. The photonic-crystal fiber offers low attenuation at the pump radiation wavelength, mechanical flexibility, high radiation stability, and low background noise. Because the excitation beam is transmitted through air inside the hollow-core fiber, silica Raman scattering is much reduced, improving the quality of the spectra obtained using probes of this design. Preliminary results show that the new probe design decreases the Raman background from the silica by approximately an order of magnitude compared to solid-core silica Raman probes.

  11. Slow cortical potential Neurofeedback and self-management training in outpatient care for children with ADHD: study protocol and first preliminary results of a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Hanna eChristiansen

    2014-11-01

    Full Text Available Background: Treatment for children with attention deficit/hyperactivity disorder (ADHD today is predominantly pharmacological. While it is the most common treatment, it might not always be the most appropriate one. Moreover, long term effects remain unclear. Behavior therapy and non-pharmacological treatments such as neurofeedback (NF are promising alternatives, though there are no routine outpatient care/effectiveness studies yet that have included children with medication or changes in medication.Methods/design: This paper presents the protocol of a randomized controlled trial to compare the effectiveness of a Slow Cortical Potential (SCP NF protocol with self-management (SM in a high frequent outpatient care setting. Both groups (NF/SM receive a total of 30 high frequent therapy sessions. Additionally, 6 sessions are reserved for comorbid problems. The primary outcome measure is the reduction of ADHD core symptoms according to parent and teacher ratings.Preliminary Results: Untill now 58 children were included in the study (48 males, with a mean age of 8.42 (1.34 years, and a mean IQ of 110 (13.37. Conners-3 parent and teacher ratings were used to estimate core symptom change. Since the study is still ongoing, and children are in different study stages, pre-post and follow-up results are not yet available for all children included. Preliminary results suggest overall good pre-post effects, though. For parent and teacher ratings an ANOVA with repeated measures yielded overall satisfying pre-post effects (η2 .175 to .513. Differences between groups (NF vs. SM could not yet be established (p = .81.Discussion: This is the first randomized controlled trial to test the effectiveness of a NF protocol in a high frequent outpatient care setting that does not exclude children on or with changes in medication. First preliminary results show positive effects. The rationale for the trial, the design, and the strengths and limitations of the study are

  12. Investigation of intravalence, core-valence and core-core electron correlation effects in polonium atomic structure calculations

    Science.gov (United States)

    Quinet, Pascal

    2014-09-01

    A detailed investigation of the atomic structure and radiative parameters involving the lowest states within the 6p4, 6p36d, 6p37s, 6p37p and 6p37d configurations of neutral polonium is reported in the present paper. Using different physical models based on the pseudo-relativistic Hartree-Fock approach, the influence of intravalence, core-valence and core-core electron correlation on the atomic parameters is discussed in detail. This work allowed us to fix the spectroscopic designation of some experimental level energy values and to provide for the first time a set of reliable oscillator strengths corresponding to 31 Po I spectral lines in the wavelength region from 175 to 987 nm.

  13. GREEN CORE HOUSE

    Directory of Open Access Journals (Sweden)

    NECULAI Oana

    2017-05-01

    Full Text Available The Green Core House is a construction concept with low environmental impact, having as main central element a greenhouse. The greenhouse has the innovative role to use the biomass energy provided by plants to save energy. Although it is the central piece, the greenhouse is not the most innovative part of the Green Core House, but the whole building ensemble because it integrates many other sustainable systems as "waste purification systems", "transparent photovoltaic panels" or "double skin façades".

  14. Birefringent hollow core fibers

    DEFF Research Database (Denmark)

    Roberts, John

    2007-01-01

    Hollow core photonic crystal fiber (HC-PCF), fabricated according to a nominally non-birefringent design, shows a degree of un-controlled birefringence or polarization mode dispersion far in excess of conventional non polarization maintaining fibers. This can degrade the output pulse in many...... and an increased overlap between the polarization modes at the glass interfaces. The interplay between these effects leads to a wavelength for optimum polarization maintenance, lambda(PM), which is detuned from the wavelength of highest birefringence. By a suitable fiber design involving antiresonance of the core...

  15. Birefringent hollow core fibers

    DEFF Research Database (Denmark)

    Roberts, John

    2007-01-01

    Hollow core photonic crystal fiber (HC-PCF), fabricated according to a nominally non-birefringent design, shows a degree of un-controlled birefringence or polarization mode dispersion far in excess of conventional non polarization maintaining fibers. This can degrade the output pulse in many...... and an increased overlap between the polarization modes at the glass interfaces. The interplay between these effects leads to a wavelength for optimum polarization maintenance, lambda(PM), which is detuned from the wavelength of highest birefringence. By a suitable fiber design involving antiresonance of the core...

  16. Combining nutation and surface gravity observations to estimate the Earth's core and inner core resonant frequencies

    Science.gov (United States)

    Ziegler, Yann; Lambert, Sébastien; Rosat, Séverine; Nurul Huda, Ibnu; Bizouard, Christian

    2017-04-01

    Nutation time series derived from very long baseline interferometry (VLBI) and time varying surface gravity data recorded by superconducting gravimeters (SG) have long been used separately to assess the Earth's interior via the estimation of the free core and inner core resonance effects on nutation or tidal gravity. The results obtained from these two techniques have been shown recently to be consistent, making relevant the combination of VLBI and SG observables and the estimation of Earth's interior parameters in a single inversion. We present here the intermediate results of the ongoing project of combining nutation and surface gravity time series to improve estimates of the Earth's core and inner core resonant frequencies. We use VLBI nutation time series spanning 1984-2016 derived by the International VLBI Service for geodesy and astrometry (IVS) as the result of a combination of inputs from various IVS analysis centers, and surface gravity data from about 15 SG stations. We address here the resonance model used for describing the Earth's interior response to tidal excitation, the data preparation consisting of the error recalibration and amplitude fitting for nutation data, and processing of SG time-varying gravity to remove any gaps, spikes, steps and other disturbances, followed by the tidal analysis with the ETERNA 3.4 software package, the preliminary estimates of the resonant periods, and the correlations between parameters.

  17. LC21-Hopes and Cautions for the Library of Congress; The NSF National Science, Mathematics, Engineering, and Technology Education Digital Library (NSDL) Program: A Progress Report; A Grammar of Dublin Core; Measuring the Impact of an Electronic Journal Collection on Library Costs: A Framework and Preliminary Observations; Emulation As a Digital Preservation Strategy.

    Science.gov (United States)

    O'Donnell, James J.; Zia, Lee L.; Baker, Thomas; Montgomery, Carol Hansen; Granger, Stewart

    2000-01-01

    Includes five articles: (1) discusses Library of Congress efforts to include digital materials; (2) describes the National Science Foundation (NSF) digital library program to improve science, math, engineering, and technology education; (3) explains Dublin Core grammar; (4) measures the impact of electronic journals on library costs; and (5)…

  18. Investigation of EAS cores

    Science.gov (United States)

    Shaulov, S. B.; Beyl, P. F.; Beysembaev, R. U.; Beysembaeva, E. A.; Bezshapov, S. P.; Borisov, A. S.; Cherdyntceva, K. V.; Chernyavsky, M. M.; Chubenko, A. P.; Dalkarov, O. D.; Denisova, V. G.; Erlykin, A. D.; Kabanova, N. V.; Kanevskaya, E. A.; Kotelnikov, K. A.; Morozov, A. E.; Mukhamedshin, R. A.; Nam, R. A.; Nesterova, N. M.; Nikolskaya, N. M.; Pavluchenko, V. P.; Piskal, V. V.; Puchkov, V. S.; Pyatovsky, S. E.; Ryabov, V. A.; Sadykov, T. Kh.; Schepetov, A. L.; Smirnova, M. D.; Stepanov, A. V.; Uryson, A. V.; Vavilov, Yu. N.; Vildanov, N. G.; Vildanova, L. I.; Zayarnaya, I. S.; Zhanceitova, J. K.; Zhukov, V. V.

    2017-06-01

    The development of nuclear-electromagnetic cascade models in air in the late forties have shown informational content of the study of cores of extensive air showers (EAS). These investigations were the main goal in different experiments which were carried out over many years by a variety of methods. Outcomes of such investigations obtained in the HADRON experiment using an X-ray emulsion chamber (XREC) as a core detector are considered. The Ne spectrum of EAS associated with γ-ray families, spectra of γ-rays (hadrons) in EAS cores and the Ne dependence of the muon number, ⟨Nμ⟩, in EAS with γ-ray families are obtained for the first time at energies of 1015-1017 eV with this method. A number of new effects were observed, namely, an abnormal scaling violation in hadron spectra which are fundamentally different from model predictions, an excess of muon number in EAS associated with γ-ray families, and the penetrating component in EAS cores. It is supposed that the abnormal behavior of γ-ray spectra and Ne dependence of the muon number are explained by the emergence of a penetrating component in the 1st PCR spectrum `knee' range. Nuclear and astrophysical explanations of the origin of the penetrating component are discussed. The necessity of considering the contribution of a single close cosmic-ray source to explain the PCR spectrum in the knee range is noted.

  19. Some Core Contested Concepts

    Science.gov (United States)

    Chomsky, Noam

    2015-01-01

    Core concepts of language are highly contested. In some cases this is legitimate: real empirical and conceptual issues arise. In other cases, it seems that controversies are based on misunderstanding. A number of crucial cases are reviewed, and an approach to language is outlined that appears to have strong conceptual and empirical motivation, and…

  20. Looking for Core Values

    Science.gov (United States)

    Carter, Margie

    2010-01-01

    People who view themselves as leaders, not just managers or teachers, are innovators who focus on clarifying core values and aligning all aspects of the organization with these values to grow their vision. A vision for an organization can't be just one person's idea. Visions grow by involving people in activities that help them name and create…

  1. Nucleosome Core Particle

    Science.gov (United States)

    1997-01-01

    Nucleosome Core Particle grown on STS-81. The fundamental structural unit of chromatin and is the basis for organization within the genome by compaction of DNA within the nucleus of the cell and by making selected regions of chromosomes available for transcription and replication. Principal Investigator's are Dr. Dan Carter and Dr. Gerard Bunick of New Century Pharmaceuticals.

  2. Investigation of EAS cores

    Directory of Open Access Journals (Sweden)

    Shaulov S.B.

    2017-01-01

    Full Text Available The development of nuclear-electromagnetic cascade models in air in the late forties have shown informational content of the study of cores of extensive air showers (EAS. These investigations were the main goal in different experiments which were carried out over many years by a variety of methods. Outcomes of such investigations obtained in the HADRON experiment using an X-ray emulsion chamber (XREC as a core detector are considered. The Ne spectrum of EAS associated with γ-ray families, spectra of γ-rays (hadrons in EAS cores and the Ne dependence of the muon number, ⟨Nμ⟩, in EAS with γ-ray families are obtained for the first time at energies of 1015–1017 eV with this method. A number of new effects were observed, namely, an abnormal scaling violation in hadron spectra which are fundamentally different from model predictions, an excess of muon number in EAS associated with γ-ray families, and the penetrating component in EAS cores. It is supposed that the abnormal behavior of γ-ray spectra and Ne dependence of the muon number are explained by the emergence of a penetrating component in the 1st PCR spectrum ‘knee’ range. Nuclear and astrophysical explanations of the origin of the penetrating component are discussed. The necessity of considering the contribution of a single close cosmic-ray source to explain the PCR spectrum in the knee range is noted.

  3. Modeling Core Collapse Supernovae

    Science.gov (United States)

    Mezzacappa, Anthony

    2017-01-01

    Core collapse supernovae, or the death throes of massive stars, are general relativistic, neutrino-magneto-hydrodynamic events. The core collapse supernova mechanism is still not in hand, though key components have been illuminated, and the potential for multiple mechanisms for different progenitors exists. Core collapse supernovae are the single most important source of elements in the Universe, and serve other critical roles in galactic chemical and thermal evolution, the birth of neutron stars, pulsars, and stellar mass black holes, the production of a subclass of gamma-ray bursts, and as potential cosmic laboratories for fundamental nuclear and particle physics. Given this, the so called ``supernova problem'' is one of the most important unsolved problems in astrophysics. It has been fifty years since the first numerical simulations of core collapse supernovae were performed. Progress in the past decade, and especially within the past five years, has been exponential, yet much work remains. Spherically symmetric simulations over nearly four decades laid the foundation for this progress. Two-dimensional modeling that assumes axial symmetry is maturing. And three-dimensional modeling, while in its infancy, has begun in earnest. I will present some of the recent work from the ``Oak Ridge'' group, and will discuss this work in the context of the broader work by other researchers in the field. I will then point to future requirements and challenges. Connections with other experimental, observational, and theoretical efforts will be discussed, as well.

  4. The Earth's Core.

    Science.gov (United States)

    Jeanloz, Raymond

    1983-01-01

    The nature of the earth's core is described. Indirect evidence (such as that determined from seismological data) indicates that it is an iron alloy, solid toward its center but otherwise liquid. Evidence also suggests that it is the turbulent flow of the liquid that generates the earth's magnetic field. (JN)

  5. Some Core Contested Concepts

    Science.gov (United States)

    Chomsky, Noam

    2015-01-01

    Core concepts of language are highly contested. In some cases this is legitimate: real empirical and conceptual issues arise. In other cases, it seems that controversies are based on misunderstanding. A number of crucial cases are reviewed, and an approach to language is outlined that appears to have strong conceptual and empirical motivation, and…

  6. Languages for Dublin Core.

    Science.gov (United States)

    Baker, Thomas

    1998-01-01

    Focusing on languages for the Dublin Core, examines the experience of some related ways to seek semantic interoperability through simplicity: planned languages, interlingua constructs, and pidgins. Also defines the conceptual and organizational problem of maintaining a metadata standard in multiple languages. (AEF)

  7. Core calculations of JMTR

    Energy Technology Data Exchange (ETDEWEB)

    Nagao, Yoshiharu [Japan Atomic Energy Research Inst., Oarai, Ibaraki (Japan). Oarai Research Establishment

    1998-03-01

    In material testing reactors like the JMTR (Japan Material Testing Reactor) of 50 MW in Japan Atomic Energy Research Institute, the neutron flux and neutron energy spectra of irradiated samples show complex distributions. It is necessary to assess the neutron flux and neutron energy spectra of an irradiation field by carrying out the nuclear calculation of the core for every operation cycle. In order to advance core calculation, in the JMTR, the application of MCNP to the assessment of core reactivity and neutron flux and spectra has been investigated. In this study, in order to reduce the time for calculation and variance, the comparison of the results of the calculations by the use of K code and fixed source and the use of Weight Window were investigated. As to the calculation method, the modeling of the total JMTR core, the conditions for calculation and the adopted variance reduction technique are explained. The results of calculation are shown. Significant difference was not observed in the results of neutron flux calculations according to the difference of the modeling of fuel region in the calculations by K code and fixed source. The method of assessing the results of neutron flux calculation is described. (K.I.)

  8. The core and cosmopolitans

    DEFF Research Database (Denmark)

    Dahlander, Linus; Frederiksen, Lars

    2012-01-01

    Users often interact and help each other solve problems in communities, but few scholars have explored how these relationships provide opportunities to innovate. We analyze the extent to which people positioned within the core of a community as well as people that are cosmopolitans positioned...

  9. Schumpeter's core works revisited

    DEFF Research Database (Denmark)

    Andersen, Esben Sloth

    2012-01-01

    This paper organises Schumpeter’s core books in three groups: the programmatic duology,the evolutionaryeconomic duology,and the socioeconomic synthesis. By analysing these groups and their interconnections from the viewpoint of modern evolutionaryeconomics,the paper summarises resolved problems...

  10. Adult educators' core competences

    DEFF Research Database (Denmark)

    Wahlgren, Bjarne

    2016-01-01

    environment as well as the kind of adult education concerned (e.g. basic education, work-related education etc.). However, it seems that it is possible to identify certain competence requirements which transcend national, cultural and functional boundaries. This research note summarises these common or “core...

  11. Adult educators' core competences

    DEFF Research Database (Denmark)

    Wahlgren, Bjarne

    2016-01-01

    environment as well as the kind of adult education concerned (e.g. basic education, work-related education etc.). However, it seems that it is possible to identify certain competence requirements which transcend national, cultural and functional boundaries. This research note summarises these common or “core...

  12. Developing a research skill set.

    Science.gov (United States)

    You, Y Nancy; Bednarski, Brian

    2014-06-01

    The recent decades have witnessed a significant expansion in the diversity of career paths within academic surgery. Although the skills for providing exemplary surgical care and for maintaining a strong work ethic are the foundations of an academic surgeon, deliberate career planning and organized acquisition of research skills contribute to the success of an academic career. In this article, we identify a set of core academic skills and propose a framework for acquiring them. We also describe specific career paths within academic surgery and provide an overview of the opportunities for acquiring specific skill sets. The development of an academic career is challenging, and firm knowledge of the personal motivations will sustain and endure the time needed for acquiring the needed skills.

  13. Boundary Crossings and Violations in Clinical Settings

    Directory of Open Access Journals (Sweden)

    V K Aravind

    2012-01-01

    Full Text Available Principles of beneficence, autonomy, and nonmaleficence, compassion along with fiduciary partnership are the core concepts in the doctor-patient relationship in therapeutic settings. There are varieties of reasons for boundary problems. Physicians ignorance, exploitative character, emotional vulnerability moral weakness and similar factors may pave the way for boundary issues resulting in nonsexual or sexual boundary crossings and violations.

  14. Boundary crossings and violations in clinical settings.

    Science.gov (United States)

    Aravind, V K; Krishnaram, V D; Thasneem, Z

    2012-01-01

    Principles of beneficence, autonomy, and nonmaleficence, compassion along with fiduciary partnership are the core concepts in the doctor-patient relationship in therapeutic settings. There are varieties of reasons for boundary problems. Physicians ignorance, exploitative character, emotional vulnerability moral weakness and similar factors may pave the way for boundary issues resulting in nonsexual or sexual boundary crossings and violations.

  15. Environmental Survey preliminary report

    Energy Technology Data Exchange (ETDEWEB)

    1988-04-01

    This report presents the preliminary findings from the first phase of the Environmental Survey of the United States Department of Energy (DOE) Sandia National Laboratories conducted August 17 through September 4, 1987. The objective of the Survey is to identify environmental problems and areas of environmental risk associated with Sandia National Laboratories-Albuquerque (SNLA). The Survey covers all environmental media and all areas of environmental regulation. It is being performed in accordance with the DOE Environmental Survey Manual. This phase of the Survey involves the review of existing site environmental data, observations of the operations carried on at SNLA, and interviews with site personnel. 85 refs., 49 figs., 48 tabs.

  16. Ruiz Volcano: Preliminary report

    Science.gov (United States)

    Ruiz Volcano, Colombia (4.88°N, 75.32°W). All times are local (= GMT -5 hours).An explosive eruption on November 13, 1985, melted ice and snow in the summit area, generating lahars that flowed tens of kilometers down flank river valleys, killing more than 20,000 people. This is history's fourth largest single-eruption death toll, behind only Tambora in 1815 (92,000), Krakatau in 1883 (36,000), and Mount Pelée in May 1902 (28,000). The following briefly summarizes the very preliminary and inevitably conflicting information that had been received by press time.

  17. 慢性乙肝患者HBV核心基因一组单核苷酸多态性与血清HBV DNA水平的相关性研究%Study on the correlation between a set of single nucleotide polymorphisms of hepatitis B virus core gene and serum HBV DNA levels in patients with chronic hepatitis B

    Institute of Scientific and Technical Information of China (English)

    李一荣; 王雪平; 陈凤花; 袁琳; 马荣红; 温晓波; 周志明

    2011-01-01

    Objective To investigate the relation between a set of single nucleotide polymorphisms (SNP) in core gene of HBV in chronic hepatitis B patients and HBV DNA levels. Methods PCR restriction fragment length polymorphism(PCR-RFLP) assay and restriction enzyme Tsp509I were adopted to determine HBV SNP in HBV core gene. Nucleotide sequences of core gene were determined using the dideoxy chain termination method. HBV DNA levels were quantitated with real-time PCR. Results Five typical RFLP patterns, RFLP-C, RFLP-D, RFLP-E, RFLP-G and RFLP-C/G mixture were found and the distribution of HBV RFLP patterns was as follows: C, 61. 5% ; D, 2. 6% ; E, 9.6%; G, 16.7%; C/G mixture, 9.6%. Five SNPs, A165T, A336C, A336T, T337C and T385C, were found to be associated with RFLP patterns change and only SNP A336C or A336T caused the substitution of Glu-83 with Asp in HBcAg. The serum HBV DNA levels in RFLP-C group were higher than that in RFLP-G (P =0. 02) and RFLP-C/G group(P = 0. 006) , respectively, furthermore, the positive rate of serum ALT in RFLP-C/G group was lower than that in RFLP-C, RFLP-E and RFLP-G group, respectively. Under the condition of HBeAg-positive, the serum HBV DNA levels in RFLP-C group were higher than that in RFLP-G (P = 0. 015) and RFLP-C/G group(P =0.008) , respectively. Conclusion PCR-RFLP used in this study can be adopted to determine HBV SNPs, not genotypes in Chinese patients with chronic hepatitis B. The serum HBV DNA level in RFLP-C group higher than that in RFLP-G or RFLP-C/G group maybe associated with amino acid mutation, Glu83 Asp.%目的 研究慢性乙肝患者HBV核心基因的单核苷酸多态性(SNP)与血清HBV DNA水平的相关关系.方法 采用PCR-RFLP和限制性内切酶Tsp509I榆测HBV核心基因的SNP,采用双脱氧终止法对核心基因进行序列测定,实时荧光PCR技术用于HBVDNA水平的定量检测.结果 慢性乙肝人群中发现5种典型的PCR-RFLP图谱,分别是RFLP-C、RFLP-D、RFLP-E、RFLP-G和RFLP-C/G,各

  18. Preliminary Cluster Size and Efficiencies results of CMS RPC at GIF++

    CERN Document Server

    Gonzalez Blanco Gonzalez, Genoveva

    2016-01-01

    A brief description and first preliminary results of the Efficiencies and Cluster Size measurements of the CMS Resistive Plate Chambers, will be presented inside the Gamma Irradiation Facility GIF++ at CERN. Preliminary studies that sets the base performance measurements of CMS RPC for starting aging studies.

  19. Core Elements of Outpatient Antibiotic Stewardship.

    Science.gov (United States)

    Sanchez, Guillermo V; Fleming-Dutra, Katherine E; Roberts, Rebecca M; Hicks, Lauri A

    2016-11-11

    The Core Elements of Outpatient Antibiotic Stewardship provides a framework for antibiotic stewardship for outpatient clinicians and facilities that routinely provide antibiotic treatment. This report augments existing guidance for other clinical settings. In 2014 and 2015, respectively, CDC released the Core Elements of Hospital Antibiotic Stewardship Programs and the Core Elements of Antibiotic Stewardship for Nursing Homes. Antibiotic stewardship is the effort to measure and improve how antibiotics are prescribed by clinicians and used by patients. Improving antibiotic prescribing involves implementing effective strategies to modify prescribing practices to align them with evidence-based recommendations for diagnosis and management. The four core elements of outpatient antibiotic stewardship are commitment, action for policy and practice, tracking and reporting, and education and expertise. Outpatient clinicians and facility leaders can commit to improving antibiotic prescribing and take action by implementing at least one policy or practice aimed at improving antibiotic prescribing practices. Clinicians and leaders of outpatient clinics and health care systems can track antibiotic prescribing practices and regularly report these data back to clinicians. Clinicians can provide educational resources to patients and families on appropriate antibiotic use. Finally, leaders of outpatient clinics and health systems can provide clinicians with education aimed at improving antibiotic prescribing and with access to persons with expertise in antibiotic stewardship. Establishing effective antibiotic stewardship interventions can protect patients and improve clinical outcomes in outpatient health care settings.

  20. CFD Analysis of Core Bypass Phenomena

    Energy Technology Data Exchange (ETDEWEB)

    Richard W. Johnson; Hiroyuki Sato; Richard R. Schultz

    2010-03-01

    The U.S. Department of Energy is exploring the potential for the VHTR which will be either of a prismatic or a pebble-bed type. One important design consideration for the reactor core of a prismatic VHTR is coolant bypass flow which occurs in the interstitial regions between fuel blocks. Such gaps are an inherent presence in the reactor core because of tolerances in manufacturing the blocks and the inexact nature of their installation. Furthermore, the geometry of the graphite blocks changes over the lifetime of the reactor because of thermal expansion and irradiation damage. The existence of the gaps induces a flow bias in the fuel blocks and results in unexpected increase of maximum fuel temperature. Traditionally, simplified methods such as flow network calculations employing experimental correlations are used to estimate flow and temperature distributions in the core design. However, the distribution of temperature in the fuel pins and graphite blocks as well as coolant outlet temperatures are strongly coupled with the local heat generation rate within fuel blocks which is not uniformly distributed in the core. Hence, it is crucial to establish mechanistic based methods which can be applied to the reactor core thermal hydraulic design and safety analysis. Computational Fluid Dynamics (CFD) codes, which have a capability of local physics based simulation, are widely used in various industrial fields. This study investigates core bypass flow phenomena with the assistance of commercial CFD codes and establishes a baseline for evaluation methods. A one-twelfth sector of the hexagonal block surface is modeled and extruded down to whole core length of 10.704m. The computational domain is divided vertically with an upper reflector, a fuel section and a lower reflector. Each side of the sector grid can be set as a symmetry boundary

  1. CFD Analysis of Core Bypass Phenomena

    Energy Technology Data Exchange (ETDEWEB)

    Richard W. Johnson; Hiroyuki Sato; Richard R. Schultz

    2009-11-01

    The U.S. Department of Energy is exploring the potential for the VHTR which will be either of a prismatic or a pebble-bed type. One important design consideration for the reactor core of a prismatic VHTR is coolant bypass flow which occurs in the interstitial regions between fuel blocks. Such gaps are an inherent presence in the reactor core because of tolerances in manufacturing the blocks and the inexact nature of their installation. Furthermore, the geometry of the graphite blocks changes over the lifetime of the reactor because of thermal expansion and irradiation damage. The existence of the gaps induces a flow bias in the fuel blocks and results in unexpected increase of maximum fuel temperature. Traditionally, simplified methods such as flow network calculations employing experimental correlations are used to estimate flow and temperature distributions in the core design. However, the distribution of temperature in the fuel pins and graphite blocks as well as coolant outlet temperatures are strongly coupled with the local heat generation rate within fuel blocks which is not uniformly distributed in the core. Hence, it is crucial to establish mechanistic based methods which can be applied to the reactor core thermal hydraulic design and safety analysis. Computational Fluid Dynamics (CFD) codes, which have a capability of local physics based simulation, are widely used in various industrial fields. This study investigates core bypass flow phenomena with the assistance of commercial CFD codes and establishes a baseline for evaluation methods. A one-twelfth sector of the hexagonal block surface is modeled and extruded down to whole core length of 10.704m. The computational domain is divided vertically with an upper reflector, a fuel section and a lower reflector. Each side of the one-twelfth grid can be set as a symmetry boundary

  2. Application of Core Dynamics Modeling to Core-Mantle Interactions

    Science.gov (United States)

    Kuang, Weijia

    2003-01-01

    Observations have demonstrated that length of day (LOD) variation on decadal time scales results from exchange of axial angular momentum between the solid mantle and the core. There are in general four core-mantle interaction mechanisms that couple the core and the mantle. Of which, three have been suggested likely the dominant coupling mechanism for the decadal core-mantle angular momentum exchange, namely, gravitational core-mantle coupling arising from density anomalies in the mantle and in the core (including the inner core), the electromagnetic coupling arising from Lorentz force in the electrically conducting lower mantle (e.g. D-layer), and the topographic coupling arising from non-hydrostatic pressure acting on the core-mantle boundary (CMB) topography. In the past decades, most effort has been on estimating the coupling torques from surface geomagnetic observations (kinematic approach), which has provided insights on the core dynamical processes. In the meantime, it also creates questions and concerns on approximations in the studies that may invalidate the corresponding conclusions. The most serious problem is perhaps the approximations that are inconsistent with dynamical processes in the core, such as inconsistencies between the core surface flow beneath the CMB and the CMB topography, and that between the D-layer electric conductivity and the approximations on toroidal field at the CMB. These inconsistencies can only be addressed with numerical core dynamics modeling. In the past few years, we applied our MoSST (Modular, Scalable, Self-consistent and Three-dimensional) core dynamics model to study core-mantle interactions together with geodynamo simulation, aiming at assessing the effect of the dynamical inconsistencies in the kinematic studies on core-mantle coupling torques. We focus on topographic and electromagnetic core-mantle couplings and find that, for the topographic coupling, the consistency between the core flow and the CMB topography is

  3. Preliminary results of ANAIS-25

    CERN Document Server

    Amaré, J; Cuesta, C; García, E; Ginestra, C; Martínez, M; Oliván, M A; Ortigoza, Y; de Solórzano, A Ortiz; Pobes, C; Puimedón, J; Sarsa, M L; Villar, P; Villar, J A

    2013-01-01

    The ANAIS (Annual Modulation with NaI(Tl) Scintillators) experiment aims at the confirmation of the DAMA/LIBRA signal using the same target and technique at the Canfranc Underground Laboratory. 250 kg of ultrapure NaI(Tl) crystals will be used as a target, divided into 20 modules, each coupled to two photomultipliers. Two NaI(Tl) crystals of 12.5 kg each, grown by Alpha Spectra from a powder having a potassium level under the limit of our analytical techniques, form the ANAIS-25 set-up. The background contributions are being carefully studied and preliminary results are presented: their natural potassium content in the bulk has been quantified, as well as the uranium and thorium radioactive chains presence in the bulk through the discrimination of the corresponding alpha events by PSA, and due to the fast commissioning, the contribution from cosmogenic activated isotopes is clearly identified and their decay observed along the first months of data taking. Following the procedures established with ANAIS-0 and ...

  4. The solar core as never seen before

    Energy Technology Data Exchange (ETDEWEB)

    Eff-Darwich, A; Korzennik, S G, E-mail: adarwich@iac.es, E-mail: skorzennik@cfa.harvard.edu [Instituto de Astrofisica de Canarias (IAC), E-38200 La Laguna, Tenerife (Spain); Department de Edafologia y Geologia, Universidad de La Laguna (ULL), E-38206 La Laguna, Tenerife (Spain); Harvard-Smithsonian Center for Astrophysics, 60 Garden St. Cambridge, MA, 02138 (United States)

    2011-01-01

    One of the main drawbacks in the analysis of the dynamics of the solar core comes from the lack of consistent data sets that cover the low and intermediate degree range (l = 1,200). It is usually necessary to merge data obtained from different instruments and/or fitting methodologies and hence one introduces undesired systematic errors. In contrast, we present the results of analyzing MDI rotational splittings derived by a single fitting methodology applied to 4608-, 2304-, etc..., down to 182-day long time series. The direct comparison of these data sets and the analysis of the numerical inversion results have allowed us to constrain the dynamics of the solar core and to establish the accuracy of these data as a function of the length of the time-series.

  5. Fuzzy sets, rough sets, multisets and clustering

    CERN Document Server

    Dahlbom, Anders; Narukawa, Yasuo

    2017-01-01

    This book is dedicated to Prof. Sadaaki Miyamoto and presents cutting-edge papers in some of the areas in which he contributed. Bringing together contributions by leading researchers in the field, it concretely addresses clustering, multisets, rough sets and fuzzy sets, as well as their applications in areas such as decision-making. The book is divided in four parts, the first of which focuses on clustering and classification. The second part puts the spotlight on multisets, bags, fuzzy bags and other fuzzy extensions, while the third deals with rough sets. Rounding out the coverage, the last part explores fuzzy sets and decision-making.

  6. The Partial Fuzzy Set

    OpenAIRE

    Dr.Pranita Goswami

    2011-01-01

    The Partial Fuzzy Set is a portion of the Fuzzy Set which is again a Fuzzy Set. In the Partial Fuzzy Set the baseline is shifted from 0 to 1 to any of its α cuts . In this paper we have fuzzified a portion of the Fuzzy Set by transformation

  7. Additive manufacturing technology (direct metal laser sintering) as a novel approach to fabricate functionally graded titanium implants: preliminary investigation of fabrication parameters.

    Science.gov (United States)

    Lin, Wei-Shao; Starr, Thomas L; Harris, Bryan T; Zandinejad, Amirali; Morton, Dean

    2013-01-01

    This article describes the preliminary findings of the mechanical properties of functionally graded titanium with controlled distribution of porosity and a reduced Young's modulus on the basis of a computeraided design (CAD) file, using the rapid-prototyping, direct metal laser sintering (DMLS) technique. Sixty specimens of Ti-6Al-4V were created using a DMLS machine (M270) following the standard for tensile testing of metals. One group was fabricated with only 170 W of laser energy to create fully dense specimens (control group). The remaining specimens all featured an outer fully dense "skin" layer and a partially sintered porous inner "core" region. The outer "skin" of each specimen was scanned at 170 W and set at a thickness of 0.35, 1.00, or 1.50 mm for different specimen groups. The inner "core" of each specimen was scanned at a lower laser power (43 or 85 W). The partially sintered core was clearly visible in all specimens, with somewhat greater porosity with the lower laser power. However, the amount of porosity in the core region was not related to the laser power alone; thinner skin layers resulted in higher porosity for the same power values in the core structure. The lowest Young's modulus achieved, 35 GPa, is close to that of bone and was achieved with a laser power of 43 W and a skin thickness of 0.35 mm, producing a core that comprised 74% of the total volume. Additive manufacturing technology may provide an efficient alternative way to fabricate customized dental implants based on a CAD file with a functionally graded structure that may minimize stress shielding and improve the long-term performance of dental implants.

  8. Severe accident modeling of a PWR core with different cladding materials

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, S. C. [Westinghouse Electric Company LLC, 5801 Bluff Road, Columbia, SC 29209 (United States); Henry, R. E.; Paik, C. Y. [Fauske and Associates, Inc., 16W070 83rd Street, Burr Ridge, IL 60527 (United States)

    2012-07-01

    The MAAP v.4 software has been used to model two severe accident scenarios in nuclear power reactors with three different materials as fuel cladding. The TMI-2 severe accident was modeled with Zircaloy-2 and SiC as clad material and a SBO accident in a Zion-like, 4-loop, Westinghouse PWR was modeled with Zircaloy-2, SiC, and 304 stainless steel as clad material. TMI-2 modeling results indicate that lower peak core temperatures, less H 2 (g) produced, and a smaller mass of molten material would result if SiC was substituted for Zircaloy-2 as cladding. SBO modeling results indicate that the calculated time to RCS rupture would increase by approximately 20 minutes if SiC was substituted for Zircaloy-2. Additionally, when an extended SBO accident (RCS creep rupture failure disabled) was modeled, significantly lower peak core temperatures, less H 2 (g) produced, and a smaller mass of molten material would be generated by substituting SiC for Zircaloy-2 or stainless steel cladding. Because the rate of SiC oxidation reaction with elevated temperature H{sub 2}O (g) was set to 0 for this work, these results should be considered preliminary. However, the benefits of SiC as a more accident tolerant clad material have been shown and additional investigation of SiC as an LWR core material are warranted, specifically investigations of the oxidation kinetics of SiC in H{sub 2}O (g) over the range of temperatures and pressures relevant to severe accidents in LWR 's. (authors)

  9. A Preliminary Exploration of Transformation of Political Advantage of Party Organization into Core Enterprise Competitivity in Logistics Enterprises%物流企业党组织政治优势转化为企业核心竞争力的路径初探

    Institute of Scientific and Technical Information of China (English)

    徐术

    2015-01-01

    In this paper, we analyzed the political advantage of the party organization of the logistics enterprise and its manifestations, then generalized the core competitivity of the logistics enterprises into leadership, cohesion, enforcement, influence and control, and at the end, discussed the path to transform the political advantage of the party organization into the core competitivity of the logistics enterprise.%分析了物流企业党组织的政治优势及其表现,将物流企业的核心竞争力概括为领导力、凝聚力、执行力、影响力、管控力等五个方面,探讨了将党的政治优势转化为物流企业核心竞争力的实现路径.

  10. USGS Core Research Center (CRC) Collection of Core

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Core Research Center (CRC) was established in 1974 by the U.S. Geological Survey (USGS) to preserve valuable rock cores for use by scientists and educators from...

  11. Ice Cores of the National Ice Core Laboratory

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The U.S. National Ice Core Laboratory (NICL) is a facility for storing, curating, and studying ice cores recovered from the polar regions of the world. It provides...

  12. Coupling Mode of Dual-Core Micro Structured Fibers

    CERN Document Server

    Debbal, Mohammed

    2015-01-01

    The photonic crystal fibers (PCF) or air-silica microstructured fibers consist of a periodic array of dielectric transverse. By introducing a defect in this structure, it is possible to guide the light by a photonic bandgap effect, whose properties are different fundamentally from the guide by total internal reflection that takes place in conventional fibers. PCF with two cores have significant potential, and this is one of the main motivations witches led us to approach this theme in this article. Analysis of the inter-core coupling was also necessary to study the problem of crosstalk. Their knowledge is important because it is a preliminary work to the study and understanding of multi-core PCF or an array of guides in the microstructured cladding. It then presents the main results on the effects of beating between the various modes under linear conditions.

  13. Multi-core Processors based Network Intrusion Detection Method

    Directory of Open Access Journals (Sweden)

    Ziqian Wan

    2012-09-01

    Full Text Available It is becoming increasingly hard to build an intrusion detection system (IDS, because of the higher traffic throughput and the rising sophistication of attacking. Scale will be an important issue to address in the intrusion detection area. For hardware, tomorrow’s performance gains will come from multi-core architectures in which a number of CPU executes concurrently. We take the advantage of multi-core processors’ full power for intrusion detection in this work. We present an intrusion detection system based on the Snort open-source IDS that exploits the computational power of MIPS multi-core architecture to offload the costly pattern matching operations from the CPU, and thus increase the system’s processing throughput. A preliminary experiment demonstrates the potential of this system. The experiment results indicate that this method can be used effectively to speed up intrusion detection systems.

  14. A Study on Numerical Simulation of Core-Shooting Process

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    In order to evaluate the main factors influencing the core-shooting process and to optimize the design of core boxes, the fluid-particle (air-sand) model has been built based on the two-phase flow theory. The fluid phase, air, and the particulate phase, sand granules, have been treated as a continuum. By using this model, it is possible to simulate the flow and compaction behavior of sand particles during the core-shooting process. To benchmark the calculated results, the shooting process has been recorded with a digital high speed camera, and the inlet condition of sand particles has also been achieved by using the camera. The preliminary results have showed that the calculation is in agreement with the testing results.

  15. Core Outlet Temperature Study

    Energy Technology Data Exchange (ETDEWEB)

    Moisseytsev, A. [Argonne National Laboratory (ANL), Argonne, IL (United States); Hoffman, E. [Argonne National Laboratory (ANL), Argonne, IL (United States); Majumdar, S. [Argonne National Laboratory (ANL), Argonne, IL (United States)

    2008-07-28

    It is a known fact that the power conversion plant efficiency increases with elevation of the heat addition temperature. The higher efficiency means better utilization of the available resources such that higher output in terms of electricity production can be achieved for the same size and power of the reactor core or, alternatively, a lower power core could be used to produce the same electrical output. Since any nuclear power plant, such as the Advanced Burner Reactor, is ultimately built to produce electricity, a higher electrical output is always desirable. However, the benefits of the higher efficiency and electricity production usually come at a price. Both the benefits and the disadvantages of higher reactor outlet temperatures are analyzed in this work.

  16. Geomagnetism of earth's core

    Science.gov (United States)

    Benton, E. R.

    1983-01-01

    Instrumentation, analytical methods, and research goals for understanding the behavior and source of geophysical magnetism are reviewed. Magsat, launched in 1979, collected global magnetometer data and identified the main terrestrial magnetic fields. The data has been treated by representing the curl-free field in terms of a scalar potential which is decomposed into a truncated series of spherical harmonics. Solutions to the Laplace equation then extend the field upward or downward from the measurement level through intervening spaces with no source. Further research is necessary on the interaction between harmonics of various spatial scales. Attempts are also being made to analytically model the main field and its secular variation at the core-mantle boundary. Work is also being done on characterizing the core structure, composition, thermodynamics, energetics, and formation, as well as designing a new Magsat or a tethered satellite to be flown on the Shuttle.

  17. Geomagnetism of earth's core

    Science.gov (United States)

    Benton, E. R.

    1983-01-01

    Instrumentation, analytical methods, and research goals for understanding the behavior and source of geophysical magnetism are reviewed. Magsat, launched in 1979, collected global magnetometer data and identified the main terrestrial magnetic fields. The data has been treated by representing the curl-free field in terms of a scalar potential which is decomposed into a truncated series of spherical harmonics. Solutions to the Laplace equation then extend the field upward or downward from the measurement level through intervening spaces with no source. Further research is necessary on the interaction between harmonics of various spatial scales. Attempts are also being made to analytically model the main field and its secular variation at the core-mantle boundary. Work is also being done on characterizing the core structure, composition, thermodynamics, energetics, and formation, as well as designing a new Magsat or a tethered satellite to be flown on the Shuttle.

  18. Dynamics of core accretion

    Science.gov (United States)

    Nelson, Andrew F.; Ruffert, Maximilian

    2013-02-01

    We perform three-dimensional hydrodynamic simulations of gas flowing around a planetary core of mass Mpl = 10M⊕ embedded in a near Keplerian background flow, using a modified shearing box approximation. We assume an ideal gas behaviour following an equation of state with a fixed ratio of the specific heats, γ = 1.42, consistent with the conditions of a moderate-temperature background disc with solar composition. No radiative heating or cooling is included in the models. We employ a nested grid hydrodynamic code implementing the `Piecewise Parabolic Method' with as many as six fixed nested grids, providing spatial resolution on the finest grid comparable to the present-day diameters of Neptune and Uranus. We find that a strongly dynamically active flow develops such that no static envelope can form. The activity is not sensitive to plausible variations in the rotation curve of the underlying disc. It is sensitive to the thermodynamic treatment of the gas, as modelled by prescribed equations of state (either `locally isothermal' or `locally isentropic') and the temperature of the background disc material. The activity is also sensitive to the shape and depth of the core's gravitational potential, through its mass and gravitational softening coefficient. Each of these factors influences the magnitude and character of hydrodynamic feedback of the small-scale flow on the background, and we conclude that accurate modelling of such feedback is critical to a complete understanding of the core accretion process. The varying flow pattern gives rise to large, irregular eruptions of matter from the region around the core which return matter to the background flow: mass in the envelope at one time may not be found in the envelope at any later time. No net mass accretion into the envelope is observed over the course of the simulation and none is expected, due to our neglect of cooling. Except in cases of very rapid cooling however, as defined by locally isothermal or

  19. Some core contested concepts.

    Science.gov (United States)

    Chomsky, Noam

    2015-02-01

    Core concepts of language are highly contested. In some cases this is legitimate: real empirical and conceptual issues arise. In other cases, it seems that controversies are based on misunderstanding. A number of crucial cases are reviewed, and an approach to language is outlined that appears to have strong conceptual and empirical motivation, and to lead to conclusions about a number of significant issues that differ from some conventional beliefs.

  20. Development of an International Classification of Functioning, Disability and Health (ICF)-based standard set to describe the impact of joint contractures on participation of older individuals in geriatric care settings.

    Science.gov (United States)

    Bartoszek, Gabriele; Fischer, Uli; von Clarenau, Stephan Clarmann; Grill, Eva; Mau, Wilfried; Meyer, Gabriele; Strobl, Ralf; Thiesemann, Rüdiger; Nadolny, Stephan; Müller, Martin

    2015-01-01

    Joint contractures are characterized as impairment of the physiological movement of joints due to deformity, disuse or pain and have major impact especially for older individuals in geriatric care. Some measures for the assessment of the impact of joint contractures exist. However, there is no consensus on which aspects should constantly be measured. Our objective was to develop a standard-set based on the ICF for describing functioning and disability in older individuals with joint contractures in geriatric care settings, giving special emphasis to activities and participation. The ICF-based standard set was developed in a formal decision-making and consensus process and based on an adapted version of the protocol to develop ICF Core Sets. These are sets of categories from the ICF, serving as standards for the assessment, communication and reporting of functioning and health for clinical studies, clinical encounters and multi-professional comprehensive assessment and management. Twenty-three experts from Germany and Switzerland selected 105 categories of the ICF component Activities and Participation for the ICF-based standard set. The largest number of categories was selected from the chapter Mobility (50 categories, 47.6%). The standard set for older individuals with joint contractures provides health professionals with a standard for describing patients' activity limitations and participation restrictions. The standard set also provides a common basis for the development of patient-centered measures and intervention programs. The preliminary version of the ICF-based standard set will be tested in subsequent studies with regard to its psychometric properties. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  1. Central core disease

    Directory of Open Access Journals (Sweden)

    Jungbluth Heinz

    2007-05-01

    Full Text Available Abstract Central core disease (CCD is an inherited neuromuscular disorder characterised by central cores on muscle biopsy and clinical features of a congenital myopathy. Prevalence is unknown but the condition is probably more common than other congenital myopathies. CCD typically presents in infancy with hypotonia and motor developmental delay and is characterized by predominantly proximal weakness pronounced in the hip girdle; orthopaedic complications are common and malignant hyperthermia susceptibility (MHS is a frequent complication. CCD and MHS are allelic conditions both due to (predominantly dominant mutations in the skeletal muscle ryanodine receptor (RYR1 gene, encoding the principal skeletal muscle sarcoplasmic reticulum calcium release channel (RyR1. Altered excitability and/or changes in calcium homeostasis within muscle cells due to mutation-induced conformational changes of the RyR protein are considered the main pathogenetic mechanism(s. The diagnosis of CCD is based on the presence of suggestive clinical features and central cores on muscle biopsy; muscle MRI may show a characteristic pattern of selective muscle involvement and aid the diagnosis in cases with equivocal histopathological findings. Mutational analysis of the RYR1 gene may provide genetic confirmation of the diagnosis. Management is mainly supportive and has to anticipate susceptibility to potentially life-threatening reactions to general anaesthesia. Further evaluation of the underlying molecular mechanisms may provide the basis for future rational pharmacological treatment. In the majority of patients, weakness is static or only slowly progressive, with a favourable long-term outcome.

  2. Characterization of P-Core and Absolute Equivalence of Double Sequences

    Directory of Open Access Journals (Sweden)

    Hasan Furkan

    2010-01-01

    Full Text Available The P-core of a double sequence has been defined and it is studied by many authors. In this paper, we have determined two permutations π1 and π2 on the set of natural numbers for which P-coreAπ1(x=P-coreAπ2(x for all x∈ℓ∞2.

  3. A Preliminary Rubric Design to Evaluate Mixed Methods Research

    Science.gov (United States)

    Burrows, Timothy J.

    2013-01-01

    With the increase in frequency of the use of mixed methods, both in research publications and in externally funded grants there are increasing calls for a set of standards to assess the quality of mixed methods research. The purpose of this mixed methods study was to conduct a multi-phase analysis to create a preliminary rubric to evaluate mixed…

  4. A Preliminary Rubric Design to Evaluate Mixed Methods Research

    Science.gov (United States)

    Burrows, Timothy J.

    2013-01-01

    With the increase in frequency of the use of mixed methods, both in research publications and in externally funded grants there are increasing calls for a set of standards to assess the quality of mixed methods research. The purpose of this mixed methods study was to conduct a multi-phase analysis to create a preliminary rubric to evaluate mixed…

  5. The Geoengineering Model Intercomparison Project Phase 6 (GeoMIP6: simulation design and preliminary results

    Directory of Open Access Journals (Sweden)

    B. Kravitz

    2015-10-01

    Full Text Available We present a suite of new climate model experiment designs for the Geoengineering Model Intercomparison Project (GeoMIP. This set of experiments, named GeoMIP6 (to be consistent with the Coupled Model Intercomparison Project Phase 6, builds on the previous GeoMIP project simulations, and has been expanded to address several further important topics, including key uncertainties in extreme events, the use of geoengineering as part of a portfolio of responses to climate change, and the relatively new idea of cirrus cloud thinning to allow more longwave radiation to escape to space. We discuss experiment designs, as well as the rationale for those designs, showing preliminary results from individual models when available. We also introduce a new feature, called the GeoMIP Testbed, which provides a platform for simulations that will be performed with a few models and subsequently assessed to determine whether the proposed experiment designs will be adopted as core (Tier 1 GeoMIP experiments. This is meant to encourage various stakeholders to propose new targeted experiments that address their key open science questions, with the goal of making GeoMIP more relevant to a broader set of communities.

  6. The Geoengineering Model Intercomparison Project Phase 6 (GeoMIP6): simulation design and preliminary results

    Science.gov (United States)

    Kravitz, B.; Robock, A.; Tilmes, S.; Boucher, O.; English, J. M.; Irvine, P. J.; Jones, A.; Lawrence, M. G.; MacCracken, M.; Muri, H.; Moore, J. C.; Niemeier, U.; Phipps, S. J.; Sillmann, J.; Storelvmo, T.; Wang, H.; Watanabe, S.

    2015-10-01

    We present a suite of new climate model experiment designs for the Geoengineering Model Intercomparison Project (GeoMIP). This set of experiments, named GeoMIP6 (to be consistent with the Coupled Model Intercomparison Project Phase 6), builds on the previous GeoMIP project simulations, and has been expanded to address several further important topics, including key uncertainties in extreme events, the use of geoengineering as part of a portfolio of responses to climate change, and the relatively new idea of cirrus cloud thinning to allow more longwave radiation to escape to space. We discuss experiment designs, as well as the rationale for those designs, showing preliminary results from individual models when available. We also introduce a new feature, called the GeoMIP Testbed, which provides a platform for simulations that will be performed with a few models and subsequently assessed to determine whether the proposed experiment designs will be adopted as core (Tier 1) GeoMIP experiments. This is meant to encourage various stakeholders to propose new targeted experiments that address their key open science questions, with the goal of making GeoMIP more relevant to a broader set of communities.

  7. Preliminary Results of the Herschel Gould Belt Survey in the Orion B Complex

    Science.gov (United States)

    Könyves, Vera; André, Philippe; Palmeirim, Pedro; Schneider, Nicola; Arzoumanian, Doris; Men'shchikov, Alexander

    As a preliminary result of the Herschel Gould Belt survey (André et al. 2010) in the Orion B cloud complex we find a clear connection between the locations of the detected prestellar cores and the column density values. We find that the vast majority of the gravitationally bound prestellar cores are detected above a high column density of about 6-7 × 1021 cm-2 (A V ˜ 6-7). This is in very good agreement with dense core formation thresholds found in other regions. For Orion B, a similar limit appears both in the distribution of background column density values of the prestellar cores, and in the column density PDF of the region. Within our core formation scenario, the found threshold can be translated as the column density above which the filaments become gravitationally unstable and fragment into cores.

  8. Core-seis: a code for LMFBR core seismic analysis

    Energy Technology Data Exchange (ETDEWEB)

    Chellapandi, P.; Ravi, R.; Chetal, S.C.; Bhoje, S.B. [Indira Gandhi Centre for Atomic Research, Kalpakkam (India). Reactor Group

    1995-12-31

    This paper deals with a computer code CORE-SEIS specially developed for seismic analysis of LMFBR core configurations. For demonstrating the prediction capability of the code, results are presented for one of the MONJU reactor core mock ups which deals with a cluster of 37 subassemblies kept in water. (author). 3 refs., 7 figs., 2 tabs.

  9. Core Exercises: Why You Should Strengthen Your Core Muscles

    Science.gov (United States)

    Healthy Lifestyle Fitness You know core exercises are good for you — but do you include core exercises in your fitness routine? Here's why ... 18, 2014 Original article: http://www.mayoclinic.org/healthy-lifestyle/fitness/in-depth/core-exercises/art-20044751 . Mayo Clinic Footer Legal Conditions and ...

  10. ASBench: benchmarking sets for allosteric discovery.

    Science.gov (United States)

    Huang, Wenkang; Wang, Guanqiao; Shen, Qiancheng; Liu, Xinyi; Lu, Shaoyong; Geng, Lv; Huang, Zhimin; Zhang, Jian

    2015-08-01

    Allostery allows for the fine-tuning of protein function. Targeting allosteric sites is gaining increasing recognition as a novel strategy in drug design. The key challenge in the discovery of allosteric sites has strongly motivated the development of computational methods and thus high-quality, publicly accessible standard data have become indispensable. Here, we report benchmarking data for experimentally determined allosteric sites through a complex process, including a 'Core set' with 235 unique allosteric sites and a 'Core-Diversity set' with 147 structurally diverse allosteric sites. These benchmarking sets can be exploited to develop efficient computational methods to predict unknown allosteric sites in proteins and reveal unique allosteric ligand-protein interactions to guide allosteric drug design.

  11. Generalized rough sets based on neighborhood systems and topological spaces

    Directory of Open Access Journals (Sweden)

    R. Mareay

    2016-10-01

    Full Text Available Rough sets theory is an important method for dealing with uncertainty, fuzziness and undefined objects. In this paper, we introduce a new approach for generalized rough sets based on the neighborhood systems induced by an arbitrary binary relation. Four pairs of the dual approximation operators are generated from the core of neighborhood systems. Relationship among different approximation operators are presented. We generate different topological spaces by using the core of these neighborhood systems. Relationship among different generated topologies are discussed.

  12. Interferometric synthetic aperture microscopy implementation on a floating point multi-core digital signal processer

    Science.gov (United States)

    Ahmad, Adeel; Ali, Murtaza; South, Fredrick; Monroy, Guillermo L.; Adie, Steven G.; Shemonski, Nathan; Carney, P. Scott; Boppart, Stephen A.

    2013-03-01

    The transition of optical coherence tomography (OCT) technology from the lab environment towards the more challenging clinical and point-of-care settings is continuing at a rapid pace. On one hand this translation opens new opportunities and avenues for growth, while on the other hand it also presents a new set of challenges and constraints under which OCT systems have to operate. OCT systems in the clinical environment are not only required to be user friendly and easy to operate, but should also be portable, have a smaller form factor coupled with low cost and reduced power consumption. Digital signal processors (DSP) are in a unique position to satisfy the computational requirements for OCT at a much lower cost and power consumption compared to the existing platforms such as CPU and graphics processing units (GPUs). In this work, we describe the implementation of optical coherence tomography (OCT) and interferometric synthetic aperture microscopy (ISAM) processing on a floating point multi-core DSP (C6678, Texas Instruments). ISAM is a computationally intensive data processing technique that is based on the re-sampling of the Fourier space of the data to yield spatially invariant transverse resolution in OCT. Preliminary results indicate that 2DISAM processing at 70,000 A-lines/sec and OCT at 180,000 A-lines/sec can be achieved with the current implementation using available DSP hardware.

  13. QUEST2: Sysdtem architecture deliverable set

    Energy Technology Data Exchange (ETDEWEB)

    Braaten, F.D.

    1995-02-27

    This document contains the system architecture and related documents which were developed during the Preliminary Analysis/System Architecture phase of the Quality, Environmental, Safety T-racking System redesign (QUEST2) project. Each discreet document in this deliverable set applies to a analytic effort supporting the architectural model of QUEST2. The P+ methodology cites a list of P+ documents normally included in a ``typical`` system architecture. Some of these were deferred to the release development phase of the project. The documents included in this deliverable set represent the system architecture itself. Related to that architecture are some decision support documents which provided needed information for management reviews that occurred during April. Consequently, the deliverables in this set were logically grouped and provided to support customer requirements. The remaining System Architecture Phase deliverables will be provided as a ``Supporting Documents`` deliverable set for the first release.

  14. The forced precession of the Moon's inner core

    Science.gov (United States)

    Dumberry, Mathieu; Wieczorek, Mark A.

    2016-07-01

    The tilt angle of the 18.6 year precession of the Moon's solid inner core is unknown, but it is set by a balance between gravitational and pressure torques acting on its elliptical figure. We show here that to first order, the angle of precession of the inner core of a planetary body is determined by the frequency of the free inner core nutation, ωficn, relative to the precession frequency, Ωp. If |ωficn|≪|Ωp|, the inner core is blind to the gravitational influence of the mantle. If |ωficn|≫|Ωp|, the inner core is gravitationally locked to the mantle and is nearly aligned with it. If ωficn≈Ωp, large inner core tilt angles can result from resonant excitation. Viscous inner core relaxation and electromagnetic coupling can attenuate large tilt angles. For the specific case of the Moon, we show that ωficn is to within a factor of 2 of Ωp = 2π/18.6 yr-1. For a rigid inner core, this implies a tilt of 2 to 5° with respect to the mantle, and larger if ωficn is very close to Ωp. More modest tilt angles between 0 and 0.5° result if viscous relaxation within the inner core occurs on a timescale of one lunar day. Predictions from our model may be used in an attempt to detect the gravity signal resulting from a tilted inner core, to determine the past history of the inner core tilt angle, and to assess models of dynamo generation powered by differential rotation at the core-mantle and inner core boundaries.

  15. Preliminary development scenarios for geopressured - geothermal energy resources in Louisiana and Texas

    Energy Technology Data Exchange (ETDEWEB)

    Zinn, C.D. (Univ. of Texas, Austin); Wilkins, B. Jr.; Waguespack, M.O.; Meriwether, J.

    1977-11-16

    A set of preliminary planning scenarios are presented, issues involved in refining and integrating these scenarios are illustrated and the need for a systems approach in resource evaluation and planning is emphasized. (MHR)

  16. Preliminary study of synthesis, characterization and application of core-shell nanofibers containing 5-ASA%载5-氨基水杨酸的核壳纳米纤维制备、表征及应用的初步研究

    Institute of Scientific and Technical Information of China (English)

    张妮萍; 贾张军; 刘宏翔; 许茜

    2011-01-01

    目的:构建基于载5-氨基水杨酸(5-ASA)核壳纳米纤维的递药系统,以期达到药物在结肠定位释放的目的.方法:以丙烯酸树脂Eudragit S100为壳层材料、乙基纤维素为核层材料,采用同轴电纺技术制备载5-ASA的核壳纳米纤维,考察制备核壳纳米纤维的主要影响因素;以包封率表征药物的包载情况;扫描电子显微镜(SEM)和透射电子显微镜(TEM)表征纤维的表面形态、直径、核壳结构的形成;以惠迪为参比制剂,在模拟体内胃、小肠、结肠pH环境的释放介质中,评价其释药行为的结肠定位特征.结果:成功制备了载5-ASA核壳纳米纤维,实验条件下初步获得了可用于载药的核壳纳米纤维;纤维呈表面光滑的圆柱形,形成较完全的核壳结构,平均直径为360 nm;5-ASA包载于纤维的核内,包封率为21-0%(n=6);5-ASA在模拟胃液pH环境中2 h几乎不释放,模拟小肠液pH环境中4 h的累积释放小于20%,而在模拟结肠液pH环境中4 h内可达到100%完全释放,体外结肠定位释药行为优于惠迪.结论:载5-ASA的核壳纳米纤维作为5-ASA的口服结肠定位给药系统(OCDDS)具有可行性.%Objective: To build oral colon-specific drug delivery system based on core-shell nanofibers for the purpose of the controlled release of a drug in the colon parts. Methods: Coaxial electrospinning technology was used to prepare core-shell nanofibers and drug was added into the core, selecting acrylic resin Eudragit S100 as the shell layer material and choosing ethylcellulose as the core layer material. Investigate the main effect factors during the process of preparing of core-shell nanofibers. Characterize the condition of drug package containing based on encapsulation efficiency. The shape, diameter, and core-shell structure of nanofibers were characterized by TEM and SEM. Making HuiDi as the reference preparation, in a simulated body's stomach, small intestine, colon Ph environment of release media

  17. Hollow-Core Fiber Lamp

    Science.gov (United States)

    Yi, Lin (Inventor); Tjoelker, Robert L. (Inventor); Burt, Eric A. (Inventor); Huang, Shouhua (Inventor)

    2016-01-01

    Hollow-core capillary discharge lamps on the millimeter or sub-millimeter scale are provided. The hollow-core capillary discharge lamps achieve an increased light intensity ratio between 194 millimeters (useful) and 254 millimeters (useless) light than conventional lamps. The capillary discharge lamps may include a cone to increase light output. Hollow-core photonic crystal fiber (HCPCF) may also be used.

  18. On core stability and extendability

    OpenAIRE

    Shellshear, Evan

    2007-01-01

    This paper investigates conditions under which the core of a TU cooperative game is stable. In particular the author extends the idea of extendability to find new conditions under which the core is stable. It is also shown that these new conditions are not necessary for core stability.

  19. Dual-core Itanium Processor

    CERN Multimedia

    2006-01-01

    Intel’s first dual-core Itanium processor, code-named "Montecito" is a major release of Intel's Itanium 2 Processor Family, which implements the Intel Itanium architecture on a dual-core processor with two cores per die (integrated circuit). Itanium 2 is much more powerful than its predecessor. It has lower power consumption and thermal dissipation.

  20. On core stability and extendability

    OpenAIRE

    Shellshear, Evan

    2007-01-01

    This paper investigates conditions under which the core of a TU cooperative game is stable. In particular the author extends the idea of extendability to find new conditions under which the core is stable. It is also shown that these new conditions are not necessary for core stability.