WorldWideScience

Sample records for preliminary core sets

  1. A Preliminary Core Domain Set for Clinical Trials of Shoulder Disorders: A Report from the OMERACT 2016 Shoulder Core Outcome Set Special Interest Group.

    Science.gov (United States)

    Buchbinder, Rachelle; Page, Matthew J; Huang, Hsiaomin; Verhagen, Arianne P; Beaton, Dorcas; Kopkow, Christian; Lenza, Mario; Jain, Nitin B; Richards, Bethan; Richards, Pamela; Voshaar, Marieke; van der Windt, Danielle; Gagnier, Joel J

    2017-12-01

    The Outcome Measures in Rheumatology (OMERACT) Shoulder Core Outcome Set Special Interest Group (SIG) was established to develop a core outcome set (COS) for clinical trials of shoulder disorders. In preparation for OMERACT 2016, we systematically examined all outcome domains and measurement instruments reported in 409 randomized trials of interventions for shoulder disorders published between 1954 and 2015. Informed by these data, we conducted an international Delphi consensus study including shoulder trial experts, clinicians, and patients to identify key domains that should be included in a shoulder disorder COS. Findings were discussed at a stakeholder premeeting of OMERACT. At OMERACT 2016, we sought consensus on a preliminary core domain set and input into next steps. There were 13 and 15 participants at the premeeting and the OMERACT 2016 SIG meeting, respectively (9 attended both meetings). Consensus was reached on a preliminary core domain set consisting of an inner core of 4 domains: pain, physical function/activity, global perceived effect, and adverse events including death. A middle core consisted of 3 domains: emotional well-being, sleep, and participation (recreation and work). An outer core of research required to inform the final COS was also formulated. Our next steps are to (1) analyze whether participation (recreation and work) should be in the inner core, (2) conduct a third Delphi round to finalize definitions and wording of domains and reach final endorsement for the domains, and (3) determine which instruments fulfill the OMERACT criteria for measuring each domain.

  2. Use of the International Classification of Functioning, Disability and Health to identify preliminary comprehensive and brief core sets for Guillain Barre syndrome.

    Science.gov (United States)

    Khan, Fary; Pallant, Julie F

    2011-01-01

    To identify the preliminary comprehensive and brief core sets for Guillain Barre syndrome (GBS), in a Delphi process using the International Classification of Functioning, Disability and Health (ICF). Focus groups and a consensus process were used to identify ICF core sets for GBS. This included: preliminary ICF studies; empirical patient data collection for 77 GBS participants; review of the evidence base and treatment in GBS literature followed by a Delphi exercise with 23 physicians and allied health professionals in Melbourne, Australia. The expert consensus selected 99 second level ICF categories (in three rounds) which identify health domains relevant to GBS for multidisciplinary assessment. These domains were consistent with current practice and existing GBS literature. The comprehensive core set includes: 27 (23%) categories from the component 'body function', 7 (12%) categories from 'body structures', 43 (36%) from 'activities and participation' and 22 (29%) from the component 'environmental' factors. The brief set comprised 20 categories, 20% of categories in the comprehensive core set. The core set categories for GBS-related health need to be addressed in multidisciplinary care programs. Future clinical 'rating' of this set may facilitate scale development using the ICF in GBS. Further research is needed to confirm the generalisability of this set in clinical settings.

  3. Analytical Chemistry Core Capability Assessment - Preliminary Report

    International Nuclear Information System (INIS)

    Barr, Mary E.; Farish, Thomas J.

    2012-01-01

    The concept of 'core capability' can be nebulous one. Even at a fairly specific level, where core capability equals maintaining essential services, it is highly dependent upon the perspective of the requestor. Samples are submitted to analytical services because the requesters do not have the capability to conduct adequate analyses themselves. Some requests are for general chemical information in support of R and D, process control, or process improvement. Many analyses, however, are part of a product certification package and must comply with higher-level customer quality assurance requirements. So which services are essential to that customer - just those for product certification? Does the customer also (indirectly) need services that support process control and improvement? And what is the timeframe? Capability is often expressed in terms of the currently utilized procedures, and most programmatic customers can only plan a few years out, at best. But should core capability consider the long term where new technologies, aging facilities, and personnel replacements must be considered? These questions, and a multitude of others, explain why attempts to gain long-term consensus on the definition of core capability have consistently failed. This preliminary report will not try to define core capability for any specific program or set of programs. Instead, it will try to address the underlying concerns that drive the desire to determine core capability. Essentially, programmatic customers want to be able to call upon analytical chemistry services to provide all the assays they need, and they don't want to pay for analytical chemistry services they don't currently use (or use infrequently). This report will focus on explaining how the current analytical capabilities and methods evolved to serve a variety of needs with a focus on why some analytes have multiple analytical techniques, and what determines the infrastructure for these analyses. This information will be

  4. Preliminary model for core/concrete interactions

    International Nuclear Information System (INIS)

    Murfin, W.B.

    1977-08-01

    A preliminary model is described for computing the rate of penetration of concrete by a molten LWR core. Among the phenomena included are convective stirring of the melt by evolved gases, admixture of concrete decomposition products to the melt, chemical reactions, radiative heat loss, and variation of heat transfer coefficients with local pressure. The model is most applicable to a two-phase melt (metallic plus oxidic) having a fairly high metallic content

  5. Preliminary core design of IRIS-50

    International Nuclear Information System (INIS)

    Petrovic, Bojan; Franceschini, Fausto

    2009-01-01

    IRIS-50 is a small, 50 MWe, advanced PWR with integral primary system. It evolved employing the same design principles as the well known medium size (335 MWe) IRIS. These principles include the 'safety-by-design' philosophy, simple and robust design, and deployment flexibility. The 50 MWe design addresses the needs of specific applications (e.g., power generation in small regional grids, water desalination and biodiesel production at remote locations, autonomous power source for special applications, etc.). Such applications may favor or even require longer refueling cycles, or may have some other specific requirements. Impact of these requirements on the core design and refueling strategy is discussed in the paper. Trade-off between the cycle length and other relevant parameters is addressed. A preliminary core design is presented, together with the core main reactor physics performance parameters. (author)

  6. SMART core preliminary nuclear design-II

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jeong Chan; Ji, Seong Kyun; Chang, Moon Hee

    1997-06-01

    Three loading patterns for 330 MWth SMART core are constructed for 25, 33 and 29 CRDMs, and one loading pattern for larger 69-FA core with 45 CRDMs is also constructed for comparison purpose. In this study, the core consists of 57 reduced height Korean Optimized Fuel Assemblies (KOFAs) developed by KAERI. The enrichment of fuel is 4.95 w/o. As a main burnable poison, 35% B-10 enriched B{sub 4}C-Al{sub 2}O{sub 3} shim is used. To control stuck rod worth, some gadolinia bearing fuel rods are used. The U-235 enrichment of the gadolinia bearing fuel rods is 1.8 w/o as used in KOFA. All patterns return cycle length of about 3 years. Three loading patterns except 25-CRDM pattern satisfy cold shutdown condition of keff {<=} 0.99 without soluble boron. These three patterns also satisfy the refueling condition of keff {<=} 0.95. In addition to the construction of loading pattern, an editing module of MASTER PPI files for rod power history generation is developed and rod power histories are generated for 29-CRDM loading pattern. Preliminary Fq design limit is suggested as 3.71 based on KOFA design experience. (author). 9 tabs., 45 figs., 16 refs.

  7. EEA core set of indicators. Guide

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    This guide provides information on the quality of the 37 indicators in the EEA core set. Its primary role is to support improved implementation of the core set in the EEA, European topic centres and the European environment information and observation network (Eionet). In parallel, it is aimed at helping users outside the EEA/Eionet system make best use of the indicators in their own work. It is hoped that the guide will promote cooperation on improving indicator methodologies and data quality as part of the wider process to streamline and improve environmental reporting in the European Union and beyond. (au)

  8. Preliminary considerations on the startup phase for the ASTRID core

    International Nuclear Information System (INIS)

    Mignot, G.

    2015-01-01

    This paper presents preliminary considerations on the startup phase for the ASTRID core, as well as an overview of the different steps before reaching the optimised equilibrium core. The start-up phase is assumed to cover the period between loading the dummy core into the reactor (for commissioning tests) and achieving the optimised equilibrium core. Four main stages are considered: a first stage of start-up tests before fuel core loading, a second stage related to zero power and power ramp-up tests, a third stage corresponding to the transition from the first core to the equilibrium contractual core, and the last stage to reach the optimised performance for the equilibrium core. In the two last stages, a sub-assembly surveillance plan based on post-irradiation examinations is taken into account. As this work is in its preliminary stages, the first scenarios shown for the start-up phase must not be considered as the ASTRID reference scenarios. The scenarios strongly depend on the assumptions considered in the analysis, whereas those discussed in this paper aim at outlining the content and the duration of the starting phases for the ASTRID core, which will be useful in subsequently assessing the core sub-assembly fabrication needs. Assumptions for the start-up phase will be updated in accordance with progress on the ASTRID core design development and core qualification programme. (author)

  9. ABSTRACTS Preliminary Study of Strategic Inner Cores

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    When a strategic entity attempts to make a dicision, first the project must be m accoroance wlm its strategic framework as well as make the strategic inner cores prominent. The existing theories of development strategy indicate that the formation of the framework can be divided into the following parts: inside and outside environments, purpose, goal, key points, and countermeasures. The strategic inner cores that put forward by this paper is the intensification and advancement for the theory of strategic framework, strategic orientation, strategic vision and main line are inciuded. Appearance of these ideas have improved the theory and enhanced strategic practice.

  10. Core outcome sets for research and clinical practice

    NARCIS (Netherlands)

    Chiarotto, Alessandro; Ostelo, Raymond W.; Turk, Dennis C.; Buchbinder, Rachelle; Boers, Maarten

    2017-01-01

    Background This masterclass introduces the topic of core outcome sets, describing rationale and methods for developing them, and providing some examples that are relevant for clinical research and practice. Method A core outcome set is a minimum consensus-based set of outcomes that should be

  11. Towards an ICF- and IMMPACT-based pain vocational rehabilitation core set in the Netherlands.

    Science.gov (United States)

    Reneman, M F; Beemster, T T; Edelaar, M J A; van Velzen, J M; van Bennekom, C; Escorpizo, R

    2013-12-01

    For clinical use and research of pain within the context of vocational rehabilitation, a specific core set of measurements is needed. The recommendations of the International Classification of Functioning, Disability and Health (ICF) brief Core Set for Vocational Rehabilitation (VR) and those of Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) cover two broad areas. These two sources can be integrated when made applicable to vocational rehabilitation and pain. Objective To develop a core set of diagnostic and evaluative measures specifically for vocational rehabilitation of patients with subacute and chronic musculoskeletal pain, while using the brief ICF core set for VR as the reference framework in VR, and the IMMPACT recommendations in the outcome measurements around pain. Three main steps were taken. The first step was to remove irrelevant and duplicate domains of the brief ICF Core Set for Vocational Rehabilitation and the IMMPACT recommendations around pain. The second step was to match the remaining domains with existing instruments or measures. Instruments were proposed based on availability and its proven use in Dutch practice and based on proof of sufficient clinimetric properties. In step 3, the preliminary VR-Pain core set was presented to 3 expert panels: proposed users, Dutch pain rehabilitation experts, and international VR experts. Experts agreed with the majority of the proposed domains and instruments. The final VR-Pain Core Set consists of 18 domains measured with 12 instruments. All instruments possessed basic clinimetric properties. An agreed-upon VR-Pain Core Set with content that covers relevant domains for pain and VR and validated instruments measuring these domains has been developed. The VR-Pain Core Set may be used for regular clinical purposes and research in the field of vocational rehabilitation and pain, but adaptations should be considered for use outside the Netherlands.

  12. Updating the Psoriatic Arthritis (PsA) Core Domain Set

    DEFF Research Database (Denmark)

    Orbai, Ana-Maria; de Wit, Maarten; Mease, Philip J

    2017-01-01

    OBJECTIVE: To include the patient perspective in accordance with the Outcome Measures in Rheumatology (OMERACT) Filter 2.0 in the updated Psoriatic Arthritis (PsA) Core Domain Set for randomized controlled trials (RCT) and longitudinal observational studies (LOS). METHODS: At OMERACT 2016, research...... conducted to update the PsA Core Domain Set was presented and discussed in breakout groups. The updated PsA Core Domain Set was voted on and endorsed by OMERACT participants. RESULTS: We conducted a systematic literature review of domains measured in PsA RCT and LOS, and identified 24 domains. We conducted...... and breakout groups at OMERACT 2016 in which findings were presented and discussed. The updated PsA Core Domain Set endorsed with 90% agreement by OMERACT 2016 participants included musculoskeletal disease activity, skin disease activity, fatigue, pain, patient's global assessment, physical function, health...

  13. Descriptions and preliminary report on sediment cores from the southwest coastal area, Everglades National Park, Florida

    Science.gov (United States)

    Wingard, G. Lynn; Cronin, Thomas M.; Holmes, Charles W.; Willard, Debra A.; Budet, Carlos A.; Ortiz, Ruth E.

    2005-01-01

    Sediment cores were collected from five locations in the southwest coastal area of Everglades National Park, Florida, in May 2004 for the purpose of determining the ecosystem history of the area and the impacts of changes in flow through the Shark River Slough. An understanding of natural cycles of change prior to significant human disturbance allows land managers to set realistic performance measures and targets for salinity and other water quality and quantity quality measures. Preliminary examination of the cores indicates significant changes have taken place over the last 1000-2000 years. The cores collected from the inner bays - the most landward bays - are distinctly different from other estuarine sediment cores examined in Florida Bay and Biscayne Bay. Peats in the inner-bay cores from Big Lostmans Bay, Broad River Bay, and Tarpon Bay were deposited at least 1000 years before present (BP) based on radiocarbon analyses. The peats are overlain by poorly sorted organic muds and sands containing species indicative of deposition in a freshwater to very low salinity environment. The Alligator Bay core, the most northern inner-bay core, is almost entirely sand; no detailed faunal analyses or radiometric dating has been completed on this core. The Roberts River core, taken from the mouth of the River where it empties into Whitewater Bay, is lithologically and faunally similar to previously examined cores from Biscayne and Florida Bays; however, the basal unit was deposited ~2000 years before the present based on radiocarbon analyses. A definite trend of increasing salinity over time is seen in the Roberts River core, from sediments representing a terrestrially dominated freshwater environment at the bottom of the core to those representing an estuarine environment with a strong freshwater influence at the top. The changes seen at Roberts River could represent a combination of factors including rising sea-level and changes in freshwater supply, but the timing and

  14. Preliminary design of the new Proton Synchrotron Internal Dump core

    CERN Document Server

    AUTHOR|(CDS)2091975; Nuiry, François-Xavier

    The luminosity of the LHC particle accelerator at CERN is planned to be upgraded in the first half of 2020s, requiring also the upgrade of its injector accelerators, including the Proton Synchrotron (PS). The PS Internal Dumps are beam dumps located in the PS accelerator ring. They are safety devices designed to stop the circulating proton beam in order to protect the accelerator from damage due to an uncontrolled beam loss. The PS Internal Dumps need to be upgraded to be able to withstand the future higher intensity and energy proton beams. The dump core is a block of material interacting with the beam. It is located in ultra-high vacuum and moved into the beam path in 150 milliseconds by an electromagnet and spring-based actuation mechanism. The circulating proton beam is shaved by the core surface during thousands of beam revolutions. The preliminary new dump core design weighs 13 kilograms and consists of an isostatically pressed fine-grain graphite and a precipitation hardened copper alloy CuCrZr. The ...

  15. Preliminary concept of a zero power nuclear reactor core

    Energy Technology Data Exchange (ETDEWEB)

    Mai, Luiz Antonio; Siqueira, Paulo de Tarso D., E-mail: lamai@ipen.b, E-mail: ptsiquei@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2011-07-01

    The purpose of this work is to define a zero power core to study the neutronic behavior of a modern research reactor as the future RMB (Brazilian Nuclear Multipurpose reactor). The platform used was the IPEN/MB-01 nuclear reactor, installed at the Nuclear and Energy Research Institute (IPEN-CNEN/SP). Equilibrium among minimal changes in the current reactor facilities and an arrangement that will be as representative as possible of a future core were taken into account. The active parts of the elements (fuel and control/safety) were determined to be exactly equal the elements of a future reactor. After several technical discussions, a basic configuration for the zero power core was defined. This reactor will validate the neutronic calculations and will allow the execution of countless future experiments aiming a real core. Of all possible alternative configurations for the zero power core representative of a future reactor - named ZPC-MRR (Zero Power Core - Modern Research Reactor), it was concluded, through technical and practical arguments, that the core will have an array of 4 x 5 positions, with 19 fuel elements, identical in its active part to a standard MTR (Material Test Reactor), 4 control/safety elements having a unique flat surface and a central position of irradiation. The specifications of the fuel elements (FEs) are the same as defined to standard MTR in its active part, but the inferior nozzles are differentiated because ZPC-MRR will be a set without heat generation. A study of reactivity was performed using MCNP code, and it was estimated that it will have around 2700 pcm reactivity excess in its 19 FEs configuration (alike the present IPEN/MB-01 reactivity). The effective change in the IPEN/MB-01 reactor will be made only in the control rods drive mechanism. It will be necessary to modify the center of this mechanism. Major modifications in the facility will not be necessary. (author)

  16. Preliminary concept of a zero power nuclear reactor core

    International Nuclear Information System (INIS)

    Mai, Luiz Antonio; Siqueira, Paulo de Tarso D.

    2011-01-01

    The purpose of this work is to define a zero power core to study the neutronic behavior of a modern research reactor as the future RMB (Brazilian Nuclear Multipurpose reactor). The platform used was the IPEN/MB-01 nuclear reactor, installed at the Nuclear and Energy Research Institute (IPEN-CNEN/SP). Equilibrium among minimal changes in the current reactor facilities and an arrangement that will be as representative as possible of a future core were taken into account. The active parts of the elements (fuel and control/safety) were determined to be exactly equal the elements of a future reactor. After several technical discussions, a basic configuration for the zero power core was defined. This reactor will validate the neutronic calculations and will allow the execution of countless future experiments aiming a real core. Of all possible alternative configurations for the zero power core representative of a future reactor - named ZPC-MRR (Zero Power Core - Modern Research Reactor), it was concluded, through technical and practical arguments, that the core will have an array of 4 x 5 positions, with 19 fuel elements, identical in its active part to a standard MTR (Material Test Reactor), 4 control/safety elements having a unique flat surface and a central position of irradiation. The specifications of the fuel elements (FEs) are the same as defined to standard MTR in its active part, but the inferior nozzles are differentiated because ZPC-MRR will be a set without heat generation. A study of reactivity was performed using MCNP code, and it was estimated that it will have around 2700 pcm reactivity excess in its 19 FEs configuration (alike the present IPEN/MB-01 reactivity). The effective change in the IPEN/MB-01 reactor will be made only in the control rods drive mechanism. It will be necessary to modify the center of this mechanism. Major modifications in the facility will not be necessary. (author)

  17. Core Health Outcomes In Childhood Epilepsy (CHOICE): protocol for the selection of a core outcome set.

    Science.gov (United States)

    Morris, Christopher; Dunkley, Colin; Gibbon, Frances M; Currier, Janet; Roberts, Deborah; Rogers, Morwenna; Crudgington, Holly; Bray, Lucy; Carter, Bernie; Hughes, Dyfrig; Tudur Smith, Catrin; Williamson, Paula R; Gringras, Paul; Pal, Deb K

    2017-11-28

    There is increasing recognition that establishing a core set of outcomes to be evaluated and reported in trials of interventions for particular conditions will improve the usefulness of health research. There is no established core outcome set for childhood epilepsy. The aim of this work is to select a core outcome set to be used in evaluative research of interventions for children with rolandic epilepsy, as an exemplar of common childhood epilepsy syndromes. First we will identify what outcomes should be measured; then we will decide how to measure those outcomes. We will engage relevant UK charities and health professional societies as partners, and convene advisory panels for young people with epilepsy and parents of children with epilepsy. We will identify candidate outcomes from a search for trials of interventions for childhood epilepsy, statutory guidance and consultation with our advisory panels. Families, charities and health, education and neuropsychology professionals will be invited to participate in a Delphi survey following recommended practices in the development of core outcome sets. Participants will be able to recommend additional outcome domains. Over three rounds of Delphi survey participants will rate the importance of candidate outcome domains and state the rationale for their decisions. Over the three rounds we will seek consensus across and between families and health professionals on the more important outcomes. A face-to-face meeting will be convened to ratify the core outcome set. We will then review and recommend ways to measure the shortlisted outcomes using clinical assessment and/or patient-reported outcome measures. Our methodology is a proportionate and pragmatic approach to expediently produce a core outcome set for evaluative research of interventions aiming to improve the health of children with epilepsy. A number of decisions have to be made when designing a study to develop a core outcome set including defining the scope

  18. Core outcome sets in dermatology: report from the second meeting of the International Cochrane Skin Group Core Outcome Set Initiative.

    Science.gov (United States)

    Kottner, J; Jacobi, L; Hahnel, E; Alam, M; Balzer, K; Beeckman, D; Busard, C; Chalmers, J; Deckert, S; Eleftheriadou, V; Furlan, K; Horbach, S E R; Kirkham, J; Nast, A; Spuls, P; Thiboutot, D; Thorlacius, L; Weller, K; Williams, H C; Schmitt, J

    2018-04-01

    Results of clinical trials are the most important information source for generating external clinical evidence. The use of different outcomes across trials, which investigate similar interventions for similar patient groups, significantly limits the interpretation, comparability and clinical application of trial results. Core outcome sets (COSs) aim to overcome this limitation. A COS is an agreed standardized collection of outcomes that should be measured and reported in all clinical trials for a specific clinical condition. The Core Outcome Set Initiative within the Cochrane Skin Group (CSG-COUSIN) supports the development of core outcomes in dermatology. In the second CSG-COUSIN meeting held in 2017, 11 COS development groups working on skin diseases presented their current work. The presentations and discussions identified the following overarching methodological challenges for COS development in dermatology: it is not always easy to define the disease focus of a COS; the optimal method for outcome domain identification and level of detail needed to specify such domains is challenging to many; decision rules within Delphi surveys need to be improved; appropriate ways of patient involvement are not always clear. In addition, there appear to be outcome domains that may be relevant as potential core outcome domains for the majority of skin diseases. The close collaboration between methodologists in the Core Outcome Set Initiative and the international Cochrane Skin Group has major advantages for trialists, systematic reviewers and COS developers. © 2018 British Association of Dermatologists.

  19. The Mount Logan (Yukon) Ice Cores: Preliminary Results

    Science.gov (United States)

    Fisher, D. A.

    2004-05-01

    Three ice cores were taken at different elevations on or near My Logan in the years 2001 and 2002. The summit core (PRCol) comes from the summit plateau ( 5340 masl, length 187 m to bedrock, mean temperature -29 C ) and was done by the Geological Survey of Canada. The NIPR group cored 210m on the flanks of the mountain at King Col (4200 masl mean temperature -16C) and the UNH group cored 20 km from the mountain at Eclipse "Dome" (3015 masl,length 345 m mean temperature -5C) . The three cores were done cooperatively by GSC, NIPR and UNH and cover nominally 30 ka, 1 ka and 2ka respectively . Located very close to the Gulf of Alaska these core records are thought to reflect the climate history of the Pacific Ocean and having three widely spaced elevations, the sites "see" different distances to different sources. The lowest site (Eclipse) has excellent seasonals but a very muted δ 18O history with no obvious little ice age, whereas the most recent 1ka of the PRCol summit sites contains two very large and sudden δ 18O and d (deuterium excess) shifts at 1850 AD and ~ 800 AD. The δ 18O shifts which happen from one year to the next are about 4 o/oo . The summit site (PRCol) δ 18O response is "backwards", ie the Little Ice Age δ 18O values are 4 o/oo more positive than recent ones. The PRCol δ 18O and d suggest that the source water can either be ëlocalí (Gulf of Alaska) or very distant (tropics) . The Eclipse site seems only to get the local water . A massive dust storm originating in central Asia (Gobi) in April 2001 dumped a visible layer all over the St Elias Mountains and this layer was sampled, to provide a calibration "Asian dust event". The satellite and isotoic signatures both agreed that Gobi was the source. The PRCol record covers the Holocene and well back into the ice age. The transition is defined by a sudden ECM shift on the flanks of a more gradual O18 shift. Acknowledgements. Logan consortium consists of : Geological Survey of Canada : Jocelyne

  20. Establishing a core domain set to measure rheumatoid arthritis flares

    DEFF Research Database (Denmark)

    Bykerk, Vivian P; Lie, Elisabeth; Bartlett, Susan J

    2014-01-01

    OBJECTIVE: The OMERACT Rheumatoid Arthritis (RA) Flare Group (FG) is developing a data-driven, patient-inclusive, consensus-based RA flare definition for use in clinical trials, longterm observational studies, and clinical practice. At OMERACT 11, we sought endorsement of a proposed core domain set...... to measure RA flare. METHODS: Patient and healthcare professional (HCP) qualitative studies, focus groups, and literature review, followed by patient and HCP Delphi exercises including combined Delphi consensus at Outcome Measures in Rheumatology 10 (OMERACT 10), identified potential domains to measure flare...... Filter 2.0 methodology. RESULTS: A pre-meeting combined Delphi exercise for defining flare identified 9 domains as important (>70% consensus from patients or HCP). Four new patient-reported domains beyond those included in the RA disease activity core set were proposed for inclusion (fatigue...

  1. Ex-vessel core catcher design requirements and preliminary concepts evaluation

    International Nuclear Information System (INIS)

    Friedland, A.J.; Tilbrook, R.W.

    1974-01-01

    As part of the overall study of the consequences of a hypothetical failure to scram following loss of pumping power, design requirements and preliminary concepts evaluation of an ex-vessel core catcher (EVCC) were performed. EVCC is the term applied to a class of devices whose primary objective is to provide a stable subcritical and coolable configuration within containment following a postulated accident in which it is assumed that core debris has penetrated the Reactor Vessel and Guard Vessel. Under these assumed conditions a set of functional requirements were developed for an EVCC and several concepts were evaluated. The studies were specifically directed toward the FFTF design considering the restraints imposed by the physical design and construction of the FFTF plant

  2. Developing core economic outcome sets for asthma studies: a protocol for a systematic review.

    Science.gov (United States)

    Hounsome, Natalia; Fitzsimmons, Deborah; Phillips, Ceri; Patel, Anita

    2017-08-11

    Core outcome sets are standardised lists of outcomes, which should be measured and reported in all clinical studies of a specific condition. This study aims to develop core outcome sets for economic evaluations in asthma studies. Economic outcomes include items such as costs, resource use or quality-adjusted life years. The starting point in developing core outcome sets will be conducting a systematic literature review to establish a preliminary list of reporting items to be considered for inclusion in the core outcome set. We will conduct literature searches of peer-reviewed studies published from January 1990 to January 2017. These will include any comparative or observational studies (including economic models) and systematic reviews reporting economic outcomes. All identified economic outcomes will be tabulated together with the major study characteristics, such as population, study design, the nature and intensity of the intervention, mode of data collection and instrument(s) used to derive an outcome. We will undertake a 'realist synthesis review' to analyse the identified economic outcomes. The outcomes will be summarised in the context of evaluation perspectives, types of economic evaluation and methodological approaches. Parallel to undertaking a systematic review, we will conduct semistructured interviews with stakeholders (including people with personal experience of asthma, health professionals, researchers and decision makers) in order to explore additional outcomes which have not been considered, or used, in published studies. The list of outcomes generated from the systematic review and interviews with stakeholders will form the basis of a Delphi survey to refine the identified outcomes into a core outcome set. The review will not involve access to individual-level data. Findings from our systematic review will be communicated to a broad range of stakeholders including clinical guideline developers, research funders, trial registries, ethics

  3. TECHNOLOGY FOR INSTALLATION OF REINFORCED CONCRETE FLOOR SLABS LIGHTENED BY CORE DRIVERS WITH PRELIMINARY REINFORCEMENT STRESS

    OpenAIRE

    S. N. Leonovich; I. I. Peredkov

    2015-01-01

    The paper presents technology for installation of floor slabs lightened by plastic core drivers which are preliminary stressed under construction conditions.  Efficiency of such constructive solution is justified by the action of preliminary concrete compression in the tensile zone while reducing structure dead weight due to void arrangement.  The paper provides classification of systems for preliminary stress and contains recommendations on selection of the system depending on peculiariar fe...

  4. Preliminary core design calculations for the ACPR Upgrade

    International Nuclear Information System (INIS)

    Pickard, P.S.

    1976-01-01

    The goal of the Annular Core Pulse Reactor (ACPR) Upgrade design studies is to define a core configuration that provides a significant increase in pulse fluence and fission energy deposition. The reactor modification should provide as flat an energy deposition profile for experiments as feasible. The fuels examined in this study were UO 2 -BeO (5-15 w/o UO 2 ), UC-ZrC-C (200-500 mg U/cc) and U-ZrH 1.5 . The basic core concept examined was a two region core, - a high heat capacity inner core region surrounded by an outer U-ZrH 1.5 region. Survey core calculations utilizing 1D transport calculations and cross sections libraries derived from the ORNL-AMPX code examined relative fuel loadings, fuel temperatures, reactivity requirements and pulse performance improvement. Reference designs for all candidate fuels were defined utilizing 2D transport and Monte Carlo calculations. The performance implications of alternative core designs were also examined for the UO 2 -BeO and UC-ZrC-C fuel candidates. (author)

  5. Preliminary Estimation of Local Bypass Flow Gap Sizes for a Prismatic VHTR Core

    International Nuclear Information System (INIS)

    Kim, Min Hwan; Jo, Chang Keun; Lee, Won Jae

    2009-01-01

    The Very High Temperature Reactor (VHTR) has been selected for the Nuclear Hydrogen Development and Demonstration (NHDD) project. In the VHTR design, core bypass flow has been one of key issues for core thermal margins and target temperature of the core outlet. The core bypass flow in the prismatic VHTR varies with the core life due to the irradiation shrinkage/ swelling and thermal expansion of the graphite blocks, which could be a significant proportion of the total core flow. Thus, accurate prediction of the bypass flow is of major importance in assuring the core thermal margin. To predict the bypass flow, first of all, local gap sizes between graphite blocks in the core should be determined. The objectives of this work are to develop a methodology for determining the gap sizes and to perform a preliminary evaluation for a reference reactor

  6. Preliminary analysis of the proposed BN-600 benchmark core

    International Nuclear Information System (INIS)

    John, T.M.

    2000-01-01

    The Indira Gandhi Centre for Atomic Research is actively involved in the design of Fast Power Reactors in India. The core physics calculations are performed by the computer codes that are developed in-house or by the codes obtained from other laboratories and suitably modified to meet the computational requirements. The basic philosophy of the core physics calculations is to use the diffusion theory codes with the 25 group nuclear cross sections. The parameters that are very sensitive is the core leakage, like the power distribution at the core blanket interface etc. are calculated using transport theory codes under the DSN approximations. All these codes use the finite difference approximation as the method to treat the spatial variation of the neutron flux. Criticality problems having geometries that are irregular to be represented by the conventional codes are solved using Monte Carlo methods. These codes and methods have been validated by the analysis of various critical assemblies and calculational benchmarks. Reactor core design procedure at IGCAR consists of: two and three dimensional diffusion theory calculations (codes ALCIALMI and 3DB); auxiliary calculations, (neutron balance, power distributions, etc. are done by codes that are developed in-house); transport theory corrections from two dimensional transport calculations (DOT); irregular geometry treated by Monte Carlo method (KENO); cross section data library used CV2M (25 group)

  7. The Expanded FindCore Method for Identification of a Core Atom Set for Assessment of Protein Structure Prediction

    Science.gov (United States)

    Snyder, David A.; Grullon, Jennifer; Huang, Yuanpeng J.; Tejero, Roberto; Montelione, Gaetano T.

    2014-01-01

    Maximizing the scientific impact of NMR-based structure determination requires robust and statistically sound methods for assessing the precision of NMR-derived structures. In particular, a method to define a core atom set for calculating superimpositions and validating structure predictions is critical to the use of NMR-derived structures as targets in the CASP competition. FindCore (D.A. Snyder and G.T. Montelione PROTEINS 2005;59:673–686) is a superimposition independent method for identifying a core atom set, and partitioning that set into domains. However, as FindCore optimizes superimposition by sensitively excluding not-well-defined atoms, the FindCore core may not comprise all atoms suitable for use in certain applications of NMR structures, including the CASP assessment process. Adapting the FindCore approach to assess predicted models against experimental NMR structures in CASP10 required modification of the FindCore method. This paper describes conventions and a standard protocol to calculate an “Expanded FindCore” atom set suitable for validation and application in biological and biophysical contexts. A key application of the Expanded FindCore method is to identify a core set of atoms in the experimental NMR structure for which it makes sense to validate predicted protein structure models. We demonstrate the application of this Expanded FindCore method in characterizing well-defined regions of 18 NMR-derived CASP10 target structures. The Expanded FindCore protocol defines “expanded core atom sets” that match an expert’s intuition of which parts of the structure are sufficiently well-defined to use in assessing CASP model predictions. We also illustrate the impact of this analysis on the CASP GDT assessment scores. PMID:24327305

  8. Contraction core for horn belief change: preliminary report

    CSIR Research Space (South Africa)

    Booth, R

    2010-05-01

    Full Text Available In this paper the authors continue recent investigations into belief change for Horn logic. The main contribution is a result which shows that the construction method for Horn contraction for belief sets based on infraremainder sets, as recently...

  9. Preliminary Uncertainty Analysis for SMART Digital Core Protection and Monitoring System

    International Nuclear Information System (INIS)

    Koo, Bon Seung; In, Wang Kee; Hwang, Dae Hyun

    2012-01-01

    The Korea Atomic Energy Research Institute (KAERI) developed on-line digital core protection and monitoring systems, called SCOPS and SCOMS as a part of SMART plant protection and monitoring system. SCOPS simplified the protection system by directly connecting the four RSPT signals to each core protection channel and eliminated the control element assembly calculator (CEAC) hardware. SCOMS adopted DPCM3D method in synthesizing core power distribution instead of Fourier expansion method being used in conventional PWRs. The DPCM3D method produces a synthetic 3-D power distribution by coupling a neutronics code and measured in-core detector signals. The overall uncertainty analysis methodology which is used statistically combining uncertainty components of SMART core protection and monitoring system was developed. In this paper, preliminary overall uncertainty factors for SCOPS/SCOMS of SMART initial core were evaluated by applying newly developed uncertainty analysis method

  10. CONSIDER - Core Outcome Set in IAD Research: study protocol for establishing a core set of outcomes and measurements in incontinence-associated dermatitis research.

    Science.gov (United States)

    Van den Bussche, Karen; De Meyer, Dorien; Van Damme, Nele; Kottner, Jan; Beeckman, Dimitri

    2017-10-01

    This study protocol describes the methodology for the development of a core set of outcomes and a core set of measurements for incontinence-associated dermatitis. Incontinence is a widespread disorder with an important impact on quality of life. One of the most common complications is incontinence-associated dermatitis, resulting from chemical and physical irritation of the skin barrier, triggering inflammation and skin damage. Managing incontinence-associated dermatitis is an important challenge for nurses. Several interventions have been assessed in clinical trials, but heterogeneity in study outcomes complicates the comparability and standardization. To overcome this challenge, the development of a core outcome set, a minimum set of outcomes and measurements to be assessed in clinical research, is needed. A project team, International Steering Committee and panelists will be involved to guide the development of the core outcome set. The framework of the Harmonizing Outcomes Measures for Eczema roadmap endorsed by Cochrane Skin Group Core Outcomes Set Initiative, is used to inform the project design. A systematic literature review, interviews to integrate the patients' perspective and a consensus study with healthcare researchers and providers using the Delphi procedure will be performed. The project was approved by the Ethics review Committee (April 2016). This is the first project that will identify a core outcome set of outcomes and measurements for incontinence-associated dermatitis research. A core outcome set will reduce possible reporting bias, allow results comparisons and statistical pooling across trials and strengthen evidence-based practice and decision-making. This project has been registered in the Core Outcome Measures in Effectiveness Trials (COMET) database and is part of the Cochrane Skin Group Core Outcomes Set Initiative (CSG-COUSIN). © 2016 John Wiley & Sons Ltd.

  11. Towards an ICF Core Set for chronic musculoskeletal conditions: commonalities across ICF Core Sets for osteoarthritis, rheumatoid arthritis, osteoporosis, low back pain and chronic widespread pain.

    Science.gov (United States)

    Schwarzkopf, S R; Ewert, T; Dreinhöfer, K E; Cieza, A; Stucki, G

    2008-11-01

    The objective of the study was to identify commonalities among the International Classification of Functioning, Disability and Health (ICF) Core Sets of osteoarthritis (OA), osteoporosis (OP), low back pain (LBP), rheumatoid arthritis (RA) and chronic widespread pain (CWP). The aim is to identify relevant categories for the development of a tentative ICF Core Set for musculoskeletal and pain conditions. The ICF categories common to the five musculoskeletal and pain conditions in the Brief and Comprehensive ICF Core Sets were identified in three steps. In a first step, the commonalities across the Brief and Comprehensive ICF Core Sets for these conditions were examined. In a second and third step, we analysed the increase in commonalities when iteratively excluding one or two of the five conditions. In the first step, 29 common categories out of the total number of 120 categories were identified across the Comprehensive ICF Core Sets of all musculoskeletal and pain conditions, primarily in the component activities and participation. In the second and third step, we found that the exclusion of CWP across the Comprehensive ICF Core Sets increased the commonalities of the remaining four musculoskeletal conditions in a maximum of ten additional categories. The Brief ICF Core Sets of all musculoskeletal and pain conditions contain four common categories out of a total number of 62 categories. The iterative exclusion of a singular condition did not significantly increase the commonalities in the remaining. Based on our analysis, it seems possible to develop a tentative Comprehensive ICF Core Set across a number of musculoskeletal conditions including LBP, OA, OP and RA. However, the profile of functioning in people with CWP differs considerably and should not be further considered for a common ICF Core Set.

  12. Preliminary study on flexible core design of super FBR with multi-axial fuel shuffling

    International Nuclear Information System (INIS)

    Sukarman; Yamaji, Akifumi; Someya, Takayuki; Noda, Shogo

    2017-01-01

    Preliminary study has been conducted on developing a new flexible core design concept for the Supercritical water-cooled Fast Breeder Reactor (Super FBR) with multi-axial fuel shuffling. The proposed new concept focuses on the characteristic large axial coolant density change in supercritical water cooled reactors (SCWRs) when the coolant inlet temperature is below the pseudocritical point and large coolant enthalpy rise is taken in the core for achieving high thermal efficiency. The aim of the concept is to attain both the high breeding performance and good thermal-hydraulic performance at the same time. That is, short Compound System Doubling Time (CSDT) for high breeding, large coolant enthalpy rise for high thermal efficiency, and large core power. The proposed core concept consists of horizontal layers of mixed oxide (MOX) fuels and depleted uranium (DU) blanket layers at different elevation levels. Furthermore, the upper core and the lower core are separated and independent fuel shuffling schemes in these two core regions are considered. The number of fuel batches and fuel shuffling scheme of the upper core were changed to investigate influence of multi-axial fuel shuffling on the core characteristics. The core characteristics are evaluated with-three-dimensional diffusion calculations, which are fully-coupled with thermal-hydraulics calculations based on single channel analysis model. The results indicate that the proposed multi-axial fuel shuffling scheme does have a large influence on CSDT. Further investigations are necessary to develop the core concept. (author)

  13. Biogas production from pineapple core - A preliminary study

    Science.gov (United States)

    Jehan, O. S.; Sanusi, S. N. A.; Sukor, M. Z.; Noraini, M.; Buddin, M. M. H. S.; Hamid, K. H. K.

    2017-09-01

    Anaerobic digestion of pineapple waste was investigated by using pineapple core as the sole substrate. Pineapple core was chosen due to its high total sugar content thus, indicating high amount of fermentable sugar. As digestion process requires the involvement of microorganisms, wastewater from the same industry was added in the current study at ratio of 1:1 by weight. Two different sources of wastewater (Point 1 and Point 2) were used in this study to distinguish the performance of microorganism consortia in both samples. The experiment was conducted by using a lab scale batch anaerobic digester made up from 5L container with separate gas collecting system. The biogas produced was collected by using water displacement method. The experiment was conducted for 30 days and the biogas produced was collected and its volume was recorded at 3 days interval. Based on the data available, wastewater from the first point recorded higher volume of biogas with the total accumulated biogas volume is 216.1 mL. Meanwhile, wastewater sample from Point 2 produced a total of 140.5 mL of biogas, by volume. The data shows that the origin and type of microorganism undeniably play significant role in biogas production. In fact, other factors; pH of wastewater and temperature were also known to affect biogas production. The anaerobic digestion is seen as the promising and sustainable alternatives to current disposal method.

  14. Core outcome sets in women's and newborn health: a systematic review.

    Science.gov (United States)

    Duffy, Jmn; Rolph, R; Gale, C; Hirsch, M; Khan, K S; Ziebland, S; McManus, R J

    2017-09-01

    Variation in outcome collection and reporting is a serious hindrance to progress in our specialty; therefore, over 80 journals have come together to support the development, dissemination, and implementation of core outcome sets. This study systematically reviewed and characterised registered, progressing, or completed core outcome sets relevant to women's and newborn health. Systematic search using the Core Outcome Measures in Effectiveness Trial initiative and the Core Outcomes in Women's and Newborn Health initiative databases. Registry entries, protocols, systematic reviews, and core outcome sets. Descriptive statistics to describe characteristics and results. There were 49 core outcome sets registered in maternal and newborn health, with the majority registered in 2015 (n = 22; 48%) or 2016 (n = 16; 32%). Benign gynaecology (n = 8; 16%) and newborn health (n = 3; 6%) are currently under-represented. Twenty-four (52%) core outcome sets were funded by international (n = 1; core outcome sets were completed: reconstructive breast surgery (11 outcomes), preterm birth (13 outcomes), epilepsy in pregnancy (29 outcomes), and maternity care (48 outcomes). The quantitative, qualitative, and consensus methods used to develop core outcome sets varied considerably. Core outcome sets are currently being developed across women's and newborn health, although coverage of topics is variable. Development of further infrastructure to develop, disseminate, and implement core outcome sets is urgently required. Forty-nine women's and newborn core outcome sets registered. 50% funded. 7 protocols, 20 systematic reviews, and 4 core outcome sets published. @coreoutcomes @jamesmnduffy. © 2017 Royal College of Obstetricians and Gynaecologists.

  15. Preliminaries on core image analysis using fault drilling samples; Core image kaiseki kotohajime (danso kussaku core kaisekirei)

    Energy Technology Data Exchange (ETDEWEB)

    Miyazaki, T; Ito, H [Geological Survey of Japan, Tsukuba (Japan)

    1996-05-01

    This paper introduces examples of image data analysis on fault drilling samples. The paper describes the following matters: core samples used in the analysis are those obtained from wells drilled piercing the Nojima fault which has moved in the Hygoken-Nanbu Earthquake; the CORESCAN system made by DMT Corporation, Germany, used in acquiring the image data consists of a CCD camera, a light source and core rotation mechanism, and a personal computer, its resolution being about 5 pixels/mm in both axial and circumferential directions, and 24-bit full color; with respect to the opening fractures in core samples collected by using a constant azimuth coring, it was possible to derive values of the opening width, inclination angle, and travel from the image data by using a commercially available software for the personal computer; and comparison of this core image with the BHTV record and the hydrophone VSP record (travel and inclination obtained from the BHTV record agree well with those obtained from the core image). 4 refs., 4 figs.

  16. Using a situational judgement test for selection into dental core training: a preliminary analysis.

    Science.gov (United States)

    Rowett, E; Patterson, F; Cousans, F; Elley, K

    2017-05-12

    Objective and setting This paper describes the evaluation of a pilot situational judgement test (SJT) for selection into UK Dental Core Training (DCT). The SJT's psychometric properties, group differences based on gender and ethnicity, and candidate reactions were assessed.Methods The SJT targets four non-academic attributes important for success in DCT. Data were collected alongside live selection processes from five Health Education England local teams in the UK (N = 386). Candidates completed the pilot SJT and an evaluation questionnaire to examine their reactions to the test.Results SJT scores were relatively normally distributed and showed acceptable levels of internal reliability (α = 0.68). Difficulty level and partial correlations between scenarios and SJT total score were in the expected ranges (64.61% to 90.03% and r = 0.06 to 0.41, respectively). No group differences were found for gender, and group differences between White and BME candidates were minimal. Most candidates perceived the SJT as relevant to the target role, appropriate and fair.Conclusions This study demonstrated the potential suitability of an SJT for use in DCT selection. Future research should replicate these preliminary findings in other cohorts, and assess the predictive validity of the SJT for predicting key training and practice-based outcomes.

  17. Preliminary design of a borax internal core-catcher for a gas cooled fast reactor

    International Nuclear Information System (INIS)

    Dalle Donne, M.; Dorner, S.; Schumacher, G.

    1976-09-01

    Preliminary thermal calculations show that a core-catcher appears to be feasible, which is able to cope with the complete meltdown of the core and blankets of a 1,000 MWe GCFR. This core-catcher is based on borax (Na 2 B 4 O 7 ) as dissolving material of the oxide fuel and of the fission products occuring in oxide form. The borax is contained in steel boxes forming a 2.1 meter thick slab on the base of the reactor cavity inside the prestressed concrete reactor vessel, just underneath the reactor core. The fission products are dispersed in the pool formed by the liquid borax. The heat power density in the pool is conveniently reduced and the resulting heat fluxes at the borders of the pool can be safely carried away through the PCRV liner and its water cooling system. (orig.) [de

  18. Towards an ICF- and IMMPACT-Based Pain Vocational Rehabilitation Core Set in the Netherlands

    NARCIS (Netherlands)

    Reneman, M. F.; Beemster, T. T.; Edelaar, M. J. A.; van Velzen, J. M.; van Bennekom, C.; Escorpizo, R.

    2013-01-01

    Background For clinical use and research of pain within the context of vocational rehabilitation, a specific core set of measurements is needed. The recommendations of the International Classification of Functioning, Disability and Health (ICF) brief Core Set for Vocational Rehabilitation (VR) and

  19. Monte Carlo simulation of a TRIGA source driven core configuration: Preliminary results

    International Nuclear Information System (INIS)

    Burgio, N.; Ciavola, C.; Santagata, A.

    2002-01-01

    The different core configurations with a k eff ranging from 0.93 to 0.98, and their response when driven by a pulsed neutron source were simulated with MCNP4C3 (Los Alamos - Monte Carlo N Particles). Simulation results could be considered both as preliminary check for nuclear data and a conceptual design for 'source jerk' experiments on the frame of TRIGA Accelerator Driven Experiment (TRADE) on the reactor facility of Casaccia research center. (author)

  20. Setting standards to determine core clerkship grades in pediatrics.

    Science.gov (United States)

    Dudas, Robert A; Barone, Michael A

    2014-01-01

    One of the greatest challenges for clerkship directors is assigning a final grade and determining the precise point at which a student either passes or fails a clinical clerkship. The process of incorporating both subjective and objective assessment data to provide a final summative grade can be challenging. We describe our experience conducting a standard-setting exercise to set defensible cut points in a 4-tiered grading system in our pediatric clerkship. Using the Hofstee standard-setting approach, 8 faculty members participated in an exercise to establish grade cut points. These faculty members were subsequently surveyed to assess their attitudes toward the standard-setting process as well as their reactions to these newly proposed standards. We applied the new cut points to a historic cohort of 116 Johns Hopkins University School of Medicine students from the academic year 2012-2013 to assess the potential impact on grade distributions. The resultant grading schema would lead to a significant increase in the number of students receiving a failing grade and a decrease in the number of students receiving a grade of honors in a historical cohort. Faculty reported that the Hofstee method was easy to understand and fair. All faculty members thought that grade inflation presently exists within the pediatric clerkship. This study demonstrates that practical standards using the Hofstee method can be set for medical students in a pediatric clerkship in which multiple performance measures are used. Copyright © 2014 Academic Pediatric Association. Published by Elsevier Inc. All rights reserved.

  1. Language core values in a multicultural setting: An Australian experience

    Science.gov (United States)

    Smolicz, Jerzy J.

    1991-03-01

    While it has been agreed by the members of the European Community (except the UK) that all secondary students should study two EC languages in addition to their own, in Australia the recent emphasis has been on teaching languages for external trade, particularly in the Asian region. This policy over-looks the 13 per cent of the Australian population who already speak a language other than English at home (and a greater number who are second generation immigrants), and ignores the view that it is necessary to foster domestic multiculturalism in order to have fruitful links with other cultures abroad. During the 1980s there have been moves to reinforce the cultural identity of Australians of non-English speaking background, but these have sometimes been half-hearted and do not fully recognise that cultural core values, including language, have to achieve a certain critical mass in order to be sustainable. Without this recognition, semi-assimilation will continue to waste the potential cultural and economic contributions of many citizens, and to lead to frustration and eventual violence. The recent National Agenda for a Multicultural Australia addresses this concern.

  2. Preliminary Core Design Analysis of a 200MWth Pebble Bed-type VHTR

    International Nuclear Information System (INIS)

    Jo, Chang Keun; Noh, Jae Man

    2007-01-01

    This paper intends to suggest the preliminary core design analysis of a VHTR for a hydrogen production. The nuclear hydrogen system that utilizes the high temperature heat generated from the VHTR is a promising candidate for a cost effective, safe and clean supply of hydrogen in the age of hydrogen economy. Among two candidate VHTR cores, that is, a prismatic modular reactor (PMR) and a pebble bed-type reactor (PBR), we focus on the design of a 200MWth PBR (hereinafter PBR200) in this paper. Here, the 200MWth power is selected for a demonstration plant. The core configuration of the PBR200 is similar to the PBMR (Pebble Bed Modular Reactor, 400MWth) of South Africa, but the overall dimension of the reactor system is scaled-down. This paper is to suggest two candidate PBR200 cores. One is an annular core with an inner reflector (PBR200-CD1) which was presented at IWRES07, and the other is a cylindrical core without an inner reflector (PBR200-CD2)

  3. Out-of-Core Computations of High-Resolution Level Sets by Means of Code Transformation

    DEFF Research Database (Denmark)

    Christensen, Brian Bunch; Nielsen, Michael Bang; Museth, Ken

    2012-01-01

    We propose a storage efficient, fast and parallelizable out-of-core framework for streaming computations of high resolution level sets. The fundamental techniques are skewing and tiling transformations of streamed level set computations which allow for the combination of interface propagation, re...... computations are now CPU bound and consequently the overall performance is unaffected by disk latency and bandwidth limitations. We demonstrate this with several benchmark tests that show sustained out-of-core throughputs close to that of in-core level set simulations....

  4. Sedimentology and Rock Magnetism of Bailey River Peat Cores, Sudbury Area: Preliminary Results

    Science.gov (United States)

    Yurtseven, A.; Cioppa, M. T.; Dean, K.

    2009-05-01

    Magnetic measurements on peat can reveal atmospheric anthropogenic contamination. Two cores were collected from a marsh surrounding the Bailey River, 10 km north of Sudbury, Ontario, using a Russian peat borer. The BR1 core (1.4 m) was collected right at the river's edge, whereas the BR2 core (2.5 m) was collected about 50 m away from the river's edge, close to the edge of the marsh and near the forest. Significant sedimentological variation between the two cores was observed: core BR1 had several centimeter to decimeter scale fine to coarse grey sand layers at 0.14 m, 0.46 m and 0.87 m between thicker organic-rich (peat) zones, whereas core BR2 had only one 5 cm sand-rich layer at 0.94 m within the organic-rich material. The cores were subsampled at 2.5 cm intervals for laboratory magnetic analysis. Volume susceptibility was measured using a Bartington MS2B meter, and mass-specific susceptibility was then calculated. In core BR1, the sand layers had relatively higher susceptibility (13 x 10-8 m3/kg) , while the organic rich layers had very low susceptibility (0 - 2 x 10-8 m3/kg). In core BR2, which had little sand, the susceptibility variation was dominated by higher values near-surface (10 x 10-8 m3/kg), and very low susceptibility (0.3 x 10-8 m3/kg) below 0.3 m depth. Since the lithology in this core did not vary substantially, susceptibility variations may be controlled by anthropogenic deposition in the near-surface during the peak mining and smelting decades. These preliminary results suggest that any anthropogenic signal in core BR1 appears to be masked by the sedimentological variation. On pilot results from eight samples in core BR1, saturation isothermal remanence acquisition showed 95% saturation by 200 mT, and the S-ratios (0.3T/0.9T) were above 0.93, suggesting that magnetite is the major magnetization carrier. In core BR2, six out of eight samples showed similar results; however, two samples had slightly more higher coercivity minerals (90% saturation

  5. TECHNOLOGY FOR INSTALLATION OF REINFORCED CONCRETE FLOOR SLABS LIGHTENED BY CORE DRIVERS WITH PRELIMINARY REINFORCEMENT STRESS

    Directory of Open Access Journals (Sweden)

    S. N. Leonovich

    2015-01-01

    Full Text Available The paper presents technology for installation of floor slabs lightened by plastic core drivers which are preliminary stressed under construction conditions.  Efficiency of such constructive solution is justified by the action of preliminary concrete compression in the tensile zone while reducing structure dead weight due to void arrangement.  The paper provides classification of systems for preliminary stress and contains recommendations on selection of the system depending on peculiariar features of the designed construction.  Main products and materials required for execution of works , requirements to stressed wire rope reinforcement, its main characteristics have been considered in the paper.Principal diagram of the lightened preliminary stressed slab stipulates arrangement of so called  dummy caisson. Strands of reinforcement ropes are located within the framework of bars passing over supporting structures (over vertical bearing structures of  the framework and voids are formed in the cells between bars by laying hollow plastic items joined together by a cage. The paper presents technological sequence of operations required for arrangement of the lightened preliminary stressed slab, schemes for equipment arrangement and characteristics of the applied devices and units (pushing device for reinforcement ropes, hydraulic jack with delivery hydraulic pump, mixing station, injection pump and others.  Recommendations have been given for execution of works in cold weather. The paper considers problems pertaining to control quality of the materials and items which are supplied to a construction site and directly execution of works on preliminary stress of a cellular slab.The executed analysis of technology permits to conclude that it is characterized by high level of applicability for import substitution. It is necessary to consider the possibility to apply the technology at objects of various application while comparing it with other

  6. Preliminary assessment of adjuster system performance in CANDU-6 RUFIC core

    International Nuclear Information System (INIS)

    Kim, Soon Young; Suk, Ho Chun

    2002-07-01

    Four operational transients in CANDU-6 RUFIC core have been simulated to assess the adjuster system performance. These transients included startup after a short shutdown, startup after a poison-out shutdown, shim mode operation, and a stepback to 60% full power. Also, an alternative adjuster-banking scheme has been assessed in this report. The alternative adjuster-banking scheme involves rods in Bank 1 and Bank 7 being re-distributed within the two banks. In the alternative adjuster-banking scheme, Bank 1 becomes the heaviest one. The results of the preliminary assessment indicated that the adjuster system as currently designed and installed in the NU core will adequately meet the functional requirements in the RUFIC core. Comparing to the adjuster system performance in the NU core, the total worth of the adjuster in the RUFIC core is reduced, leading to less xenon override capability and shimming capability. However, the overall performance is expected to still be satisfactory. The overall results from the transient studied indicated that the alternative banking scheme does show some better performance characteristics and merits further detailed studies

  7. The Intermediate Set and Limiting Superdi erential for Coalition Games: Between the Core and the Weber Set

    Czech Academy of Sciences Publication Activity Database

    Adam, Lukáš; Kroupa, T.

    2017-01-01

    Roč. 46, č. 4 (2017), s. 891-918 ISSN 0020-7276 R&D Projects: GA ČR GA15-00735S Institutional support: RVO:67985556 Keywords : coalition game * limiting superdi erential * intermediate set * core * Weber set Subject RIV: BA - General Mathematics OBOR OECD: Statistics and probability Impact factor: 0.713, year: 2016 http://library.utia.cas.cz/separaty/2016/MTR/adam-0467365.pdf

  8. Preliminary design characteristics of the RB fast-thermal core 'HERBE'

    International Nuclear Information System (INIS)

    Pesic, M.; Marinkovic, P.

    1989-01-01

    The 'RB' is zero power heavy water critical assembly designed in 1958 in Yugoslavia. The reactor operated using natural metal uranium, 2% enriched metal uranium, and 80% enriched UO 2 fuel of Soviet origin. A study of design of fast neutron fields began in 1976 and three fast neutron fields were designed up to 1983: the external neutron converter, the experimental fuel channel and the internal neutron converter, as the first step to fast-thermal coupled system. The preliminary design characteristics of the HERBE - a new fast - thermal core at the RB reactor are shown in this paper. (author)

  9. Preliminary Assessment of Two Alternative Core Design Concepts for the Special Purpose Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Sterbentz, James W. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Werner, James E. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Hummel, Andrew J. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Kennedy, John C. [Idaho National Lab. (INL), Idaho Falls, ID (United States); O' Brien, Robert C. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Dion, Axel M. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Wright, Richard N. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Ananth, Krishnan P. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2017-11-01

    The Special Purpose Reactor (SPR) is a small 5 MWt, heat pipe-cooled, fast reactor based on the Los Alamos National Laboratory (LANL) Mega-Power concept. The LANL concept features a stainless steel monolithic core structure with drilled channels for UO2 pellet stacks and evaporator sections of the heat pipes. Two alternative active core designs are presented here that replace the monolithic core structure with simpler and easier to manufacture fuel elements. The two new core designs are simply referred to as Design A and Design B. In addition to ease of manufacturability, the fuel elements for both Design A and Design B can be individually fabricated, assembled, inspected, tested, and qualified prior to their installation into the reactor core leading to greater reactor system reliability and safety. Design A fuel elements will require the development of a new hexagonally-shaped UO2 fuel pellet. The Design A configuration will consist of an array of hexagonally-shaped fuel elements with each fuel element having a central heat pipe. This hexagonal fuel element configuration results in four radial gaps or thermal resistances per element. Neither the fuel element development, nor the radial gap issue are deemed to be serious and should not impact an aggressive reactor deployment schedule. Design B uses embedded arrays of heat pipes and fuel pins in a double-wall tank filled with liquid metal sodium. Sodium is used to thermally bond the heat pipes to the fuel pins, but its usage may create reactor transportation and regulatory challenges. An independent panel of U.S. manufacturing experts has preliminarily assessed the three SPR core designs and views Design A as simplest to manufacture. Herein are the results of a preliminary neutronic, thermal, mechanical, material, and manufacturing assessment of both Design A and Design B along with comparisons to the LANL concept (monolithic core structure). Despite the active core differences, all three reactor concepts behave

  10. Music therapy assessment in school settings: a preliminary investigation.

    Science.gov (United States)

    Wilson, B L; Smith, D S

    2000-01-01

    The present investigation was undertaken in response to music therapists working in school settings for information relating to the availability of music therapy assessments and the feasibility of standardizing an assessment instrument for music therapists to use in school settings. Five research questions were identified, and the music therapy literature was surveyed to compile responses to those questions. Three different online data bases (ERIC, PsycINFO, and Article 1st) were used, covering articles published between 1980 and 1997. Individual hand searches were done of the Arts in Psychotherapy, Journal of Music Therapy, Journal of Research in Music Education, Journal of the International Association of Music for the Handicapped, Music Therapy and Music Therapy Perspectives. The questions and responses were as follows: 1. Which music-based assessment tools are being used with children with disabilities? Little commonality in assessment tools being used by music therapists and researchers was discovered. Of the total 41 studies, 20 (49%) reported using a "named" or "titled" assessment tool, and in the remaining 51% of studies, the authors reported using an untitled, and usually experimenter-designed, original assessment tool. 2. Have certain assessments been used in more than one study? Very limited replication of existing assessments was found. Of the 16 "named" assessments, only 3 were found to be used in more than one research study. 3. Are the actual assessments published along with the articles describing their use? Only 3 of the 20 studies using named assessments were published along with the journal article. Of the remaining 21 studies using original, experimenter-designed assessment tools, only 6 (28%) had the assessment instrument published with the article. 4. What is the primary purpose for using the assessment? Six primary purposes emerged from the review of the literature: to compare with data obtained from other assessment measures or from other

  11. Standardised assessment of functioning in ADHD: consensus on the ICF Core Sets for ADHD.

    Science.gov (United States)

    Bölte, Sven; Mahdi, Soheil; Coghill, David; Gau, Susan Shur-Fen; Granlund, Mats; Holtmann, Martin; Karande, Sunil; Levy, Florence; Rohde, Luis A; Segerer, Wolfgang; de Vries, Petrus J; Selb, Melissa

    2018-02-12

    Attention-deficit/hyperactivity disorder (ADHD) is associated with significant impairments in social, educational, and occupational functioning, as well as specific strengths. Currently, there is no internationally accepted standard to assess the functioning of individuals with ADHD. WHO's International Classification of Functioning, Disability and Health-child and youth version (ICF) can serve as a conceptual basis for such a standard. The objective of this study is to develop a comprehensive, a common brief, and three age-appropriate brief ICF Core Sets for ADHD. Using a standardised methodology, four international preparatory studies generated 132 second-level ICF candidate categories that served as the basis for developing ADHD Core Sets. Using these categories and following an iterative consensus process, 20 ADHD experts from nine professional disciplines and representing all six WHO regions selected the most relevant categories to constitute the ADHD Core Sets. The consensus process resulted in 72 second-level ICF categories forming the comprehensive ICF Core Set-these represented 8 body functions, 35 activities and participation, and 29 environmental categories. A Common Brief Core Set that included 38 categories was also defined. Age-specific brief Core Sets included a 47 category preschool version for 0-5 years old, a 55 category school-age version for 6-16 years old, and a 52 category version for older adolescents and adults 17 years old and above. The ICF Core Sets for ADHD mark a milestone toward an internationally standardised functional assessment of ADHD across the lifespan, and across educational, administrative, clinical, and research settings.

  12. Validation of the Comprehensive ICF Core Set for obstructive pulmonary diseases from the perspective of physiotherapists.

    Science.gov (United States)

    Rauch, Alexandra; Kirchberger, Inge; Stucki, Gerold; Cieza, Alarcos

    2009-12-01

    The 'Comprehensive ICF Core Set for obstructive pulmonary diseases' (OPD) is an application of the International Classification of Functioning, Disability and Health (ICF) and represents the typical spectrum of problems in functioning of patients with OPD. To optimize a multidisciplinary and patient-oriented approach in pulmonary rehabilitation, in which physiotherapy plays an important role, the ICF offers a standardized language and understanding of functioning. For it to be a useful tool for physiotherapists in rehabilitation of patients with OPD, the objective of this study was to validate this Comprehensive ICF Core Set for OPD from the perspective of physiotherapists. A three-round survey based on the Delphi technique of physiotherapists who are experienced in the treatment of OPD asked about the problems, resources and aspects of environment of patients with OPD that physiotherapists treat in clinical practice (physiotherapy intervention categories). Responses were linked to the ICF and compared with the existing Comprehensive ICF Core Set for OPD. Fifty-one physiotherapists from 18 countries named 904 single terms that were linked to 124 ICF categories, 9 personal factors and 16 'not classified' concepts. The identified ICF categories were mainly third-level categories compared with mainly second-level categories of the Comprehensive ICF Core Set for OPD. Seventy of the ICF categories, all personal factors and 15 'not classified' concepts gained more than 75% agreement among the physiotherapists. Of these ICF categories, 55 (78.5%) were covered by the Comprehensive ICF Core Set for OPD. The validity of the Comprehensive ICF Core Set for OPD was largely supported by the physiotherapists. Nevertheless, ICF categories that were not covered, personal factors and not classified terms offer opportunities towards the final ICF Core Set for OPD and further research to strengthen physiotherapists' perspective in pulmonary rehabilitation.

  13. The impact of the EUSCLE Core Set Questionnaire for the assessment of cutaneous lupus erythematosus.

    Science.gov (United States)

    Kuhn, A; Patsinakidis, N; Bonsmann, G

    2010-08-01

    Epidemiological data and standard European guidelines for the diagnosis and treatment of cutaneous lupus erythematosus (CLE) are lacking in the current literature. In order to provide a standardized tool for an extensive consistent data collection, a study group of the European Society of Cutaneous Lupus Erythematosus (EUSCLE) recently developed a Core Set Questionnaire for the assessment of patients with different subtypes of CLE. The EUSCLE Core Set Questionnaire includes six sections on patient data, diagnosis, skin involvement, activity and damage of disease, laboratory analysis, and treatment. An instrument like the EUSCLE Core Set Questionnaire is essential to gain a broad and comparable data collection of patients with CLE from different European centres and to achieve consensus concerning clinical standards for the disease. The data will also be important for further characterization of the different CLE subtypes and the evaluation of therapeutic strategies; moreover, the EUSCLE Core Set Questionnaire might also be useful for the comparison of data in clinical trials. In this review, the impact of the EUSCLE Core Set Questionnaire is discussed in detail with regard to clinical and serological features as well as therapeutic modalities in CLE.

  14. Identification of preliminary core outcome domains for communication about childhood vaccination: An online Delphi survey.

    Science.gov (United States)

    Kaufman, Jessica; Ryan, Rebecca; Lewin, Simon; Bosch-Capblanch, Xavier; Glenton, Claire; Cliff, Julie; Oyo-Ita, Angela; Muloliwa, Artur Manuel; Oku, Afiong; Ames, Heather; Rada, Gabriel; Cartier, Yuri; Hill, Sophie

    2017-08-20

    Communication interventions for childhood vaccination are promising strategies to address vaccine hesitancy, but current research is limited by the outcomes measured. Most studies measure only vaccination-related outcomes, with minimal consideration of vaccine hesitancy-relevant intermediate outcomes. This impedes understanding of which interventions or elements are effective. It is also unknown which outcomes are important to the range of stakeholders affected by vaccine hesitancy. Outcome selection shapes the evidence base, informing future interventions and trials, and should reflect stakeholder priorities. Therefore, our aim was to identify which outcome domains (i.e. broad outcome categories) are most important to different stakeholders, identifying preliminary core outcome domains to inform evaluation of three common vaccination communication types: (i) communication to inform or educate, (ii) remind or recall, and (iii) enhance community ownership. We conducted a two-stage online Delphi survey, involving four stakeholder groups: parents or community members, healthcare providers, researchers, and government or non-governmental organisation representatives. Participants rated the importance of eight outcome domains for each of the three communication types. They also rated specific outcomes within one domain ("attitudes or beliefs") and provided feedback about the survey. Collectively, stakeholder groups prioritised outcome domains differently when considering the effects of different communication types. For communication that aims to (i) inform or educate, the most important outcome domain is "knowledge or understanding"; for (ii) reminder communication, "vaccination status and behaviours"; and for (iii) community engagement communication, "community participation". All stakeholder groups rated most outcome domains as very important or critical. The highest rated specific outcome within the "attitudes or beliefs" domain was "trust". This Delphi survey

  15. Environmental Indicators. A Preliminary Set = Indicateurs d'environnement. Une etude pilote.

    Science.gov (United States)

    Organisation for Economic Cooperation and Development, Paris (France).

    This document provides a preliminary set of environmental indicators by which to measure environmental performance. The indicators are patterned on the outline of the Organisation for Economic Cooperation and Development (OECD) "Report on the State of the Environment," a companion volume published in the same year. This volume is…

  16. The Preliminary GAMMA Code Thermal hydraulic Analysis for the Steady State of HTR-10 Initial Core

    Energy Technology Data Exchange (ETDEWEB)

    Jun, Ji Su; Lim, Hong Sik; Lee, Won Jae

    2006-07-15

    This report describes the preliminary thermalhydraulic analysis of HTR-10 steady state full power initial core to provide a benchmark calculation of VHTGR(Very High-Temperature Gas-Cooled Reactors) safety analysis code of GAMMA(GAs Multicomponent Mixture Analysis). The input data of GAMMA code are produced for the models of fluid block, wall block, radiation heat transfer and each component material properties in HTR-10 reactor. The temperature and flow distributions of HTR-10 steady state 10 MW{sub th} full power initial core are calculated by GAMMA code with boundary conditions of total reactor inlet flow rate of 4.32 kg/s, inlet temperature of 250 .deg. C, inlet pressure of 3 MPa, outlet pressure of 2.992 MPa and the fixed temperature at RCCS water cooling tube of 50 .deg C. The calculation results are compared with the measured solid material temperatures at 22 fixed instrumentation positions in HTR-10. The wall temperature distribution in pebble bed core shows that the minimum temperature of 358 .deg. C is located at upper core, a higher temperature zone than 829 .deg. C is located at the inner region of 0.45 m radius at the bottom of core centre, and the maximum wall temperature is 897 .deg. C. The wall temperatures linearly decreases at radially and axially farther side from the bottom of core centre. The maximum temperature of RPV is 230 .deg. C, and the maximum values of fuel average temperature and TRISO centreline temperature are 907 .deg. C and 929 .deg. C, respectively and they are much lower than the fuel temperature limitation of 1230 .deg. C. The comparsion between the GAMMA code predictions and the measured temperature data shows that the calculation results are very close to the measured values in top and side reflector region, but a great difference is appeared in bottom reflector region. Some measured data are abnormally high in bottom reflector region, and so the confirmation of data is necessary in future. Fifteen of twenty two data have a

  17. Optimization study and preliminary design for Latina NPP early core retrieval and reactor dismantling

    International Nuclear Information System (INIS)

    Macci, E.; Zirpolo, S.; Imparato, A.; Cacace, A.; Parry, D.; Walkden, P.

    2002-01-01

    In June 2000, an agreement was established between Sogin and BNFL to enable the two companies to co-operate, using their specific experiences in the decommissioning field, for the benefit of projects in Italy, the United Kingdom and for third markets. A decommissioning strategy for the Latina NPP was initially developed in a Phase 1 Study which produced a conceptual design for the decommissioning of the reactor. This study was completed in June 2000. Since then, a second study has been completed, which has further developed the strategy and produced preliminary designs for the early dismantling of the core and reactor building at Latina. The engineering and safety data were produced in order to support Sogin in the preparation of a safety case for plant decommissioning. This safety case was submitted to the Italian Regulator, ANPA, in February 2002. (author)

  18. Twin-Twin Transfusion Syndrome: study protocol for developing, disseminating, and implementing a core outcome set.

    Science.gov (United States)

    Khalil, Asma; Perry, Helen; Duffy, James; Reed, Keith; Baschat, Ahmet; Deprest, Jan; Hecher, Kurt; Lewi, Liesbeth; Lopriore, Enrico; Oepkes, Dick

    2017-07-14

    Twin-Twin Transfusion Syndrome (TTTS) is associated with an increased risk of perinatal mortality and morbidity. Several treatment interventions have been described for TTTS, including fetoscopic laser surgery, amnioreduction, septostomy, expectant management, and pregnancy termination. Over the last decade, fetoscopic laser surgery has become the primary treatment. The literature to date reports on many different outcomes, making it difficult to compare results or combine data from individual studies, limiting the value of research to guide clinical practice. With the advent and ongoing development of new therapeutic techniques, this is more important than ever. The development and use of a core outcome set has been proposed to address these issues, prioritising outcomes important to the key stakeholders, including patients. We aim to produce, disseminate, and implement a core outcome set for TTTS. An international steering group has been established to oversee the development of this core outcome set. This group includes healthcare professionals, researchers and patients. A systematic review is planned to identify previously reported outcomes following treatment for TTTS. Following completion, the identified outcomes will be evaluated by stakeholders using an international, multi-perspective online modified Delphi method to build consensus on core outcomes. This method encourages the participants towards consensus 'core' outcomes. All key stakeholders will be invited to participate. The steering group will then hold a consensus meeting to discuss results and form a core outcome set to be introduced and measured. Once core outcomes have been agreed, the next step will be to determine how they should be measured, disseminated, and implemented within an international context. The development, dissemination, and implementation of a core outcome set in TTTS will enable its use in future clinical trials, systematic reviews and clinical practice guidelines. This is

  19. Development of a core outcome set for studies involving patients undergoing major lower limb amputation for peripheral arterial disease: study protocol for a systematic review and identification of a core outcome set using a Delphi survey.

    Science.gov (United States)

    Ambler, Graeme K; Bosanquet, David C; Brookes-Howell, Lucy; Thomas-Jones, Emma; Waldron, Cherry-Ann; Edwards, Adrian G K; Twine, Christopher P

    2017-12-28

    The development of a standardised reporting set is important to ensure that research is directed towards the most important outcomes and that data is comparable. To ensure validity, the set must be agreed by a consensus of stakeholders including patients, healthcare professionals and lay representatives. There is currently no agreed core outcome set for patients undergoing major lower limb amputation for peripheral arterial disease (PAD) for either short- or medium-term research outcomes. By developing these sets we aim to rationalise future trial outcomes, facilitate meta-analysis and improve the quality and applicability of amputation research. We will undertake a comprehensive systematic review of studies of patients undergoing major lower limb amputation for PAD. Data regarding all primary and secondary outcomes reported in relevant studies will be extracted and summarised as outcome domains. We will then undertake focus groups with key stakeholders (patients, carers, health and social care workers) to collect qualitative data to identify the main short- and medium-term research outcomes for patients undergoing major lower limb amputation. Results of the systematic review and focus groups will be combined to create a comprehensive list of potential key outcomes. Stakeholders (patients, researchers and health and social care workers) will then be polled to determine which of the outcomes are considered to be important in a general context using a three-phase Delphi process. After preliminary analysis, results will be presented at a face-to-face meeting of key stakeholders for discussion and voting on the final set of core outcomes. This project is being run in parallel with a feasibility trial assessing perineural catheters in patients undergoing lower limb amputation (the PLACEMENT trial). Full ethical approval has been granted for the study (Wales REC 3 reference number 16/WA/0353). Core outcome sets will be developed for short- and medium-term outcomes of

  20. International patient and physician consensus on a psoriatic arthritis core outcome set for clinical trials

    DEFF Research Database (Denmark)

    Orbai, Ana-Maria; de Wit, Maarten; Mease, Philip

    2017-01-01

    OBJECTIVE: To identify a core set of domains (outcomes) to be measured in psoriatic arthritis (PsA) clinical trials that represent both patients' and physicians' priorities. METHODS: We conducted (1) a systematic literature review (SLR) of domains assessed in PsA; (2) international focus groups t...

  1. International Spinal Cord Injury Core Data Set (version 2.0)-including standardization of reporting

    NARCIS (Netherlands)

    Biering-Sorensen, F.; DeVivo, M. J.; Charlifue, S.; Chen, Y.; New, P. W.; Noonan, V.; Post, M. W. M.; Vogel, L.

    Study design: The study design includes expert opinion, feedback, revisions and final consensus. Objectives: The objective of the study was to present the new knowledge obtained since the International Spinal Cord Injury (SCI) Core Data Set (Version 1.0) published in 2006, and describe the

  2. Recommended patient-reported core set of symptoms to measure in adult cancer treatment trials

    NARCIS (Netherlands)

    Reeve, B.B.; Mitchell, S.A.; Dueck, A.C.; Basch, E.; Cella, D.; Miller Reilly, C.; Minasian, L.M.; Denicoff, A.M.; O'Mara, A.M.; Fisch, M.J.; Chauhan, C.; Aaronson, N.K.; Coens, C.; Watkins Bruner, D.

    2014-01-01

    Background: The National Cancer Institute’s Symptom Management and Health-Related Quality of Life Steering Committee held a clinical trials planning meeting (September 2011) to identify a core symptom set to be assessed across oncology trials for the purposes of better understanding treatment

  3. International Spinal Cord Injury Core Data Set (version 2.0)-including standardization of reporting

    NARCIS (Netherlands)

    Biering-Sørensen, F; DeVivo, M J; Charlifue, Susan; Chen, Y; New, P.W.; Noonan, V.; Post, M W M; Vogel, L.

    STUDY DESIGN: The study design includes expert opinion, feedback, revisions and final consensus. OBJECTIVES: The objective of the study was to present the new knowledge obtained since the International Spinal Cord Injury (SCI) Core Data Set (Version 1.0) published in 2006, and describe the

  4. Classification of functioning and impairment: the development of ICF core sets for autism spectrum disorder.

    Science.gov (United States)

    Bölte, Sven; de Schipper, Elles; Robison, John E; Wong, Virginia C N; Selb, Melissa; Singhal, Nidhi; de Vries, Petrus J; Zwaigenbaum, Lonnie

    2014-02-01

    Given the variability seen in Autism Spectrum Disorder (ASD), accurate quantification of functioning is vital to studying outcome and quality of life in affected individuals. The International Classification of Functioning, Disability and Health (ICF) provides a comprehensive, universally accepted framework for the description of health-related functioning. ICF Core Sets are shortlists of ICF categories that are selected to capture those aspects of functioning that are most relevant when describing a person with a specific condition. In this paper, the authors preview the process for developing ICF Core Sets for ASD, a collaboration with the World Health Organization and the ICF Research Branch. The ICF Children and Youth version (ICF-CY) was derived from the ICF and designed to capture the specific situation of the developing child. As ASD affects individuals throughout the life span, and the ICF-CY includes all ICF categories, the ICF-CY will be used in this project ("ICF(-CY)" from now on). The ICF(-CY) categories to be included in the ICF Core Sets for ASD will be determined at an ICF Core Set Consensus Conference, where evidence from four preparatory studies (a systematic review, an expert survey, a patient and caregiver qualitative study, and a clinical cross-sectional study) will be integrated. Comprehensive and Brief ICF Core Sets for ASD will be developed with the goal of providing useful standards for research and clinical practice and generating a common language for functioning and impairment in ASD in different areas of life and across the life span. © 2013 International Society for Autism Research, Wiley Periodicals, Inc.

  5. An inventory of United States and Canadian growth record sets: preliminary report.

    Science.gov (United States)

    Hunter, W S; Baumrind, S; Moyers, R E

    1993-06-01

    A listing and description of longitudinal craniofacial growth record sets currently extant on the North American continent is provided. An argument is made for the preservation of these resources and for the generation of a pooled or shared image base of duplicate craniofacial physical records. This is a preliminary report and is assumed to be incomplete. In an effort to improve our accuracy and completeness, we invite corrections and additions.

  6. International Spinal Cord Injury Core Data Set (version 2.0)

    DEFF Research Database (Denmark)

    Biering-Sørensen, F; DeVivo, M J; Charlifue, S

    2017-01-01

    STUDY DESIGN: The study design includes expert opinion, feedback, revisions and final consensus. OBJECTIVES: The objective of the study was to present the new knowledge obtained since the International Spinal Cord Injury (SCI) Core Data Set (Version 1.0) published in 2006, and describe the adjust......STUDY DESIGN: The study design includes expert opinion, feedback, revisions and final consensus. OBJECTIVES: The objective of the study was to present the new knowledge obtained since the International Spinal Cord Injury (SCI) Core Data Set (Version 1.0) published in 2006, and describe...... the adjustments made in Version 2.0, including standardization of data reporting. SETTING: International. METHODS: Comments received from the SCI community were discussed in a working group (WG); suggestions from the WG were reviewed and revisions were made. All suggested revisions were considered, and a final...... version was circulated for final approval. RESULTS: The International SCI Core Data Set (Version 2.0) consists of 25 variables. Changes made to this version include the deletion of one variable 'Total Days Hospitalized' and addition of two variables 'Date of Rehabilitation Admission' and 'Date of Death...

  7. Identification of the Core Set of Carbon-Associated Genes in a Bioenergy Grassland Soil.

    Directory of Open Access Journals (Sweden)

    Adina Howe

    Full Text Available Despite the central role of soil microbial communities in global carbon (C cycling, little is known about soil microbial community structure and even less about their metabolic pathways. Efforts to characterize soil communities often focus on identifying differences in gene content across environmental gradients, but an alternative question is what genes are similar in soils. These genes may indicate critical species or potential functions that are required in all soils. Here we identified the "core" set of C cycling sequences widely present in multiple soil metagenomes from a fertilized prairie (FP. Of 226,887 sequences associated with known enzymes involved in the synthesis, metabolism, and transport of carbohydrates, 843 were identified to be consistently prevalent across four replicate soil metagenomes. This core metagenome was functionally and taxonomically diverse, representing five enzyme classes and 99 enzyme families within the CAZy database. Though it only comprised 0.4% of all CAZy-associated genes identified in FP metagenomes, the core was found to be comprised of functions similar to those within cumulative soils. The FP CAZy-associated core sequences were present in multiple publicly available soil metagenomes and most similar to soils sharing geographic proximity. In soil ecosystems, where high diversity remains a key challenge for metagenomic investigations, these core genes represent a subset of critical functions necessary for carbohydrate metabolism, which can be targeted to evaluate important C fluxes in these and other similar soils.

  8. Development of a Draft Core Set of Domains for Measuring Shared Decision Making in Osteoarthritis

    DEFF Research Database (Denmark)

    Toupin-April, Karine; Barton, Jennifer; Fraenkel, Liana

    2015-01-01

    OBJECTIVE: Despite the importance of shared decision making for delivering patient-centered care in rheumatology, there is no consensus on how to measure its process and outcomes. The aim of this Outcome Measures in Rheumatology (OMERACT) working group is to determine the core set of domains...... for measuring shared decision making in intervention studies in adults with osteoarthritis (OA), from the perspectives of patients, health professionals, and researchers. METHODS: We followed the OMERACT Filter 2.0 method to develop a draft core domain set by (1) forming an OMERACT working group; (2) conducting...... a review of domains of shared decision making; and (3) obtaining opinions of all those involved using a modified nominal group process held at a session activity at the OMERACT 12 meeting. RESULTS: In all, 26 people from Europe, North America, and Australia, including 5 patient research partners...

  9. Towards an ICF core set for ADHD: a worldwide expert survey on ability and disability

    OpenAIRE

    de Schipper, Elles; Mahdi, Soheil; Coghill, David; de Vries, Petrus J.; Gau, Susan Shur-Fen; Granlund, Mats; Holtmann, Martin; Karande, Sunil; Levy, Florence; Almodayfer, Omar; Rohde, Luis; Tannock, Rosemary; B?lte, Sven

    2015-01-01

    This is the second in a series of four empirical studies designed to develop International Classification of Functioning, Disability and Health (ICF and Children and Youth version, ICF-CY) core sets for attention deficit hyperactivity disorder (ADHD). The objective of this stage was to gather the opinions from international experts on which ability and disability concepts were considered relevant to functioning in ADHD. An email-based survey was carried out amongst international experts in AD...

  10. High Resolution Mineral Mapping of the Oman Drilling Project Cores with Imaging Spectroscopy: Preliminary Results

    Science.gov (United States)

    Greenberger, R. N.; Ehlmann, B. L.; Kelemen, P. B.; Manning, C. E.; Teagle, D. A. H.; Harris, M.; Michibayashi, K.; Takazawa, E.

    2017-12-01

    mm-thick dolomite or calcite veins among dense sets of magnesite veins in the listvenite, indicating cross-cutting relationships that reflect changing alteration conditions with time. It also highlights key zones for sampling and additional analyses. Further data processing will provide mineralogical maps of the full 1.5 km of core.

  11. Preliminary safety analysis for key design features of KALIMER with breakeven core

    Energy Technology Data Exchange (ETDEWEB)

    Hahn, Do Hee; Kwon, Y. M.; Chang, W. P.; Suk, S. D.; Lee, Y. B.; Jeong, K. S

    2001-06-01

    KAERI is currently developing the conceptual design of a Liquid Metal Reactor, KALIMER (Korea Advanced Liquid MEtal Reactor) under the Long-term Nuclear R and D Program. KALIMER addresses key issues regarding future nuclear power plants such as plant safety, economics, proliferation, and waste. In this report, descriptions of safety design features and safety analyses results for selected ATWS accidents for the breakeven core KALIMER are presented. First, the basic approach to achieve the safety goal is introduced in Chapter 1, and the safety evaluation procedure for the KALIMER design is described in Chapter 2. It includes event selection, event categorization, description of design basis events, and beyond design basis events.In Chapter 3, results of inherent safety evaluations for the KALIMER conceptual design are presented. The KALIMER core and plant system are designed to assure benign performance during a selected set of events without either reactor control or protection system intervention. Safety analyses for the postulated anticipated transient without scram (ATWS) have been performed to investigate the KALIMER system response to the events. In Chapter 4, the design of the KALIMER containment dome and the results of its performance analyses are presented. The design of the existing containment and the KALIMER containment dome are compared in this chapter. Procedure of the containment performance analysis and the analysis results are described along with the accident scenario and source terms. Finally, a simple methodology is introduced to investigate the core energetics behavior during HCDA in Chapter 5. Sensitivity analyses have been performed for the KALIMER core behavior during super-prompt critical excursions, using mathematical formulations developed in the framework of the Modified Bethe-Tait method. Work energy potential was then calculated based on the isentropic fuel expansion model.

  12. Preliminary radiological consequence estimates for a reference LEU core for PARR

    International Nuclear Information System (INIS)

    Ali Khan, L.

    1990-01-01

    Radiological consequence analysis of a reference LEU core for Pakistan Research Reactor (PARR) has been carried out using mathematical models. It was assumed that 20% of the fuel, having an average burn-up of 50% achieved by continuously operating the reactor for 300 days at 10 MW, fails. It was further assumed that 100% of the noble gases and a fraction of iodine are released. Three modes of leakage from reactor building have been considered. These are exhaust through the normal ventilation system, through emergency ventilation system and leakage from the building. The whole body and thyroid doses have been calculated for 2 hours and 30 days at the boundaries of the exclusion zone at 450m and the low population zone at 1000m. For the releases at stack height through normal and emergency ventilation system, doses at both the boundaries remain within emergency dose limits of 300 rem for thyroid and 25 rem for the whole body. However, in the case of direct release from the containment building, the limiting thyroid dose of 300 rem, at 1000m, for 30 days exposure is achieved for a leak rate of 27% per day under Pasquill condition E. The results presented in this report are only preliminary estimates. A more accurate detailed analysis for various burnups will be carried out using standard computer codes

  13. Preliminary radiological consequence estimate for a reference LEU core for PARR

    International Nuclear Information System (INIS)

    Younus, M.; Khan, L.A.; Akhtar, K.M.; Pervez, S.

    1988-07-01

    Radiological consequence analysis of a reference LEU core for Pakistan Research Reactor (PARR) has been carried out using mathematical models. Three modes of leakage from reactor building have been considered. These are exhaust through the normal ventilation system, through emergency ventilation system and leakage from the building. The whole body and thyroid does have been calculated for the duration of 2 hours and 30 days at the boundaries of exclusion zone at 450m and low population zone at 100m. For the releases at stack height through normal and emergency ventilation systems, does at both the boundaries remain within relevant emergency does limits of 300 rem for thyroid and 25 rem for whole body. However, in case of direct release from the containment building, limiting thyroid does of 300 rem, at 1000m, for 30 days exposure is achieved for a leak rate of 27% per day under Pasquill condition E. The results presented in this report are only preliminary estimates. A more accurate detailed analysis, for various burnups, will be carried using standard computer codes. (orig./A.B)

  14. Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation.

    Science.gov (United States)

    Shinsky, Stephen A; Monteith, Kelsey E; Viggiano, Susan; Cosgrove, Michael S

    2015-03-06

    Mixed lineage leukemia protein-1 (MLL1) is a member of the SET1 family of histone H3 lysine 4 (H3K4) methyltransferases that are required for metazoan development. MLL1 is the best characterized human SET1 family member, which includes MLL1-4 and SETd1A/B. MLL1 assembles with WDR5, RBBP5, ASH2L, DPY-30 (WRAD) to form the MLL1 core complex, which is required for H3K4 dimethylation and transcriptional activation. Because all SET1 family proteins interact with WRAD in vivo, it is hypothesized they are regulated by similar mechanisms. However, recent evidence suggests differences among family members that may reflect unique regulatory inputs in the cell. Missing is an understanding of the intrinsic enzymatic activities of different SET1 family complexes under standard conditions. In this investigation, we reconstituted each human SET1 family core complex and compared subunit assembly and enzymatic activities. We found that in the absence of WRAD, all but one SET domain catalyzes at least weak H3K4 monomethylation. In the presence of WRAD, all SET1 family members showed stimulated monomethyltransferase activity but differed in their di- and trimethylation activities. We found that these differences are correlated with evolutionary lineage, suggesting these enzyme complexes have evolved to accomplish unique tasks within metazoan genomes. To understand the structural basis for these differences, we employed a "phylogenetic scanning mutagenesis" assay and identified a cluster of amino acid substitutions that confer a WRAD-dependent gain-of-function dimethylation activity on complexes assembled with the MLL3 or Drosophila trithorax proteins. These results form the basis for understanding how WRAD differentially regulates SET1 family complexes in vivo. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  15. Feasibility of using the International Classification of Functioning, Disability and Health Core Set for evaluation of fall-related risk factors in acute rehabilitation settings.

    Science.gov (United States)

    Huang, Shih W; Lin, Li F; Chou, Lin C; Wu, Mei J; Liao, Chun D; Liou, Tsan H

    2016-04-01

    Previously, we reported the use of an International Classification of Functioning (ICF) core set that can provide a holistic framework for evaluating the risk factors of falls; however, data on the feasibility of applying this core set are lacking. To investigate the feasibility of applying the fall-related ICF risk-factor core set in the case of patients in an acute-rehabilitation setting. A cross-sectional and descriptive correlational design. Acute-rehabilitation ward. A total of 273 patients who experienced fall at acute-rehabilitation ward. The data on falls were collected from the hospital's Nursing Information System (NIS) and the fall-reporting system (Adverse Event Reporting System, AERS) between 2010 and 2013. The relationship of both systems to the fall-related ICF core set was analyzed to assess the feasibility of their clinical application. We evaluated the feasibility of using the fall-related ICF risk-factor core set by using the frequency and the percentage of the fall patients in of the listed categories. The fall-related ICF risk-factor core set category b735 (muscle tone functions) exhibited a high feasibility (85.95%) for clinical application, and the category b730 (muscle power functions) covered 77.11% of the patients. The feasibility of application of the category d410 (change basic body position) was also high in the case of all fall patients (81.69%). In the acute-rehabilitation setting, the feasibility of application of the fall-related ICF risk-factor core set is high. The fall-related ICF risk-factor core set can help multidisciplinary teams develop fall-prevention strategies in acute rehabilitation wards.

  16. Core Outcome Set-STAndards for Development: The COS-STAD recommendations.

    Directory of Open Access Journals (Sweden)

    Jamie J Kirkham

    2017-11-01

    Full Text Available The use of core outcome sets (COS ensures that researchers measure and report those outcomes that are most likely to be relevant to users of their research. Several hundred COS projects have been systematically identified to date, but there has been no formal quality assessment of these studies. The Core Outcome Set-STAndards for Development (COS-STAD project aimed to identify minimum standards for the design of a COS study agreed upon by an international group, while other specific guidance exists for the final reporting of COS development studies (Core Outcome Set-STAndards for Reporting [COS-STAR].An international group of experienced COS developers, methodologists, journal editors, potential users of COS (clinical trialists, systematic reviewers, and clinical guideline developers, and patient representatives produced the COS-STAD recommendations to help improve the quality of COS development and support the assessment of whether a COS had been developed using a reasonable approach. An open survey of experts generated an initial list of items, which was refined by a 2-round Delphi survey involving nearly 250 participants representing key stakeholder groups. Participants assigned importance ratings for each item using a 1-9 scale. Consensus that an item should be included in the set of minimum standards was defined as at least 70% of the voting participants from each stakeholder group providing a score between 7 and 9. The Delphi survey was followed by a consensus discussion with the study management group representing multiple stakeholder groups. COS-STAD contains 11 minimum standards that are the minimum design recommendations for all COS development projects. The recommendations focus on 3 key domains: the scope, the stakeholders, and the consensus process.The COS-STAD project has established 11 minimum standards to be followed by COS developers when planning their projects and by users when deciding whether a COS has been developed using

  17. Core Outcome Set-STAndards for Development: The COS-STAD recommendations.

    Science.gov (United States)

    Kirkham, Jamie J; Davis, Katherine; Altman, Douglas G; Blazeby, Jane M; Clarke, Mike; Tunis, Sean; Williamson, Paula R

    2017-11-01

    The use of core outcome sets (COS) ensures that researchers measure and report those outcomes that are most likely to be relevant to users of their research. Several hundred COS projects have been systematically identified to date, but there has been no formal quality assessment of these studies. The Core Outcome Set-STAndards for Development (COS-STAD) project aimed to identify minimum standards for the design of a COS study agreed upon by an international group, while other specific guidance exists for the final reporting of COS development studies (Core Outcome Set-STAndards for Reporting [COS-STAR]). An international group of experienced COS developers, methodologists, journal editors, potential users of COS (clinical trialists, systematic reviewers, and clinical guideline developers), and patient representatives produced the COS-STAD recommendations to help improve the quality of COS development and support the assessment of whether a COS had been developed using a reasonable approach. An open survey of experts generated an initial list of items, which was refined by a 2-round Delphi survey involving nearly 250 participants representing key stakeholder groups. Participants assigned importance ratings for each item using a 1-9 scale. Consensus that an item should be included in the set of minimum standards was defined as at least 70% of the voting participants from each stakeholder group providing a score between 7 and 9. The Delphi survey was followed by a consensus discussion with the study management group representing multiple stakeholder groups. COS-STAD contains 11 minimum standards that are the minimum design recommendations for all COS development projects. The recommendations focus on 3 key domains: the scope, the stakeholders, and the consensus process. The COS-STAD project has established 11 minimum standards to be followed by COS developers when planning their projects and by users when deciding whether a COS has been developed using reasonable

  18. Design review report for rotary mode core sample truck (RMCST) modifications for flammable gas tanks, preliminary design

    International Nuclear Information System (INIS)

    Corbett, J.E.

    1996-02-01

    This report documents the completion of a preliminary design review for the Rotary Mode Core Sample Truck (RMCST) modifications for flammable gas tanks. The RMCST modifications are intended to support core sampling operations in waste tanks requiring flammable gas controls. The objective of this review was to validate basic design assumptions and concepts to support a path forward leading to a final design. The conclusion reached by the review committee was that the design was acceptable and efforts should continue toward a final design review

  19. Creation of a Unified Set of Core-Collapse Supernovae for Training of Photometric Classifiers

    Science.gov (United States)

    D'Arcy Kenworthy, William; Scolnic, Daniel; Kessler, Richard

    2017-01-01

    One of the key tasks for future supernova cosmology analyses is to photometrically distinguish type Ia supernovae (SNe) from their core collapse (CC) counterparts. In order to train programs for this purpose, it is necessary to train on a large number of core-collapse SNe. However, there are only a handful used for current programs. We plan to use the large amount of CC lightcurves available on the Open Supernova Catalog (OSC). Since this data is scraped from many different surveys, it is given in a number of photometric systems with different calibration and filters. We therefore created a program to fit smooth lightcurves (as a function of time) to photometric observations of arbitrary SNe. The Supercal method is then used to translate the smoothed lightcurves to a single photometric system. We can thus compile a training set of 782 supernovae, of which 127 are not type Ia. These smoothed lightcurves are also being contributed upstream to the OSC as derived data.

  20. Defining a core outcome set for adolescent and young adult patients with a spinal deformity

    DEFF Research Database (Denmark)

    de Kleuver, Marinus; Faraj, Sayf S A; Holewijn, Roderick M

    2017-01-01

    Background and purpose - Routine outcome measurement has been shown to improve performance in several fields of healthcare. National spine surgery registries have been initiated in 5 Nordic countries. However, there is no agreement on which outcomes are essential to measure for adolescent and young...... adult patients with a spinal deformity. The aim of this study was to develop a core outcome set (COS) that will facilitate benchmarking within and between the 5 countries of the Nordic Spinal Deformity Society (NSDS) and other registries worldwide. Material and methods - From August 2015 to September...... consensus rounds were held. Consensus was defined as agreement between at least 5 of the 7 representatives. Data were analyzed qualitatively and quantitatively. Results - Consensus was reached on the inclusion of 13 core outcome domains: "satisfaction with overall outcome of surgery", "satisfaction...

  1. Level set method for optimal shape design of MRAM core. Micromagnetic approach

    International Nuclear Information System (INIS)

    Melicher, Valdemar; Cimrak, Ivan; Keer, Roger van

    2008-01-01

    We aim at optimizing the shape of the magnetic core in MRAM memories. The evolution of the magnetization during the writing process is described by the Landau-Lifshitz equation (LLE). The actual shape of the core in one cell is characterized by the coefficient γ. Cost functional f=f(γ) expresses the quality of the writing process having in mind the competition between the full-select and the half-select element. We derive an explicit form of the derivative F=∂f/∂γ which allows for the use of gradient-type methods for the actual computation of the optimized shape (e.g., steepest descend method). The level set method (LSM) is employed for the representation of the piecewise constant coefficient γ

  2. Overlap and Nonoverlap Between the ICF Core Sets for Hearing Loss and Otology and Audiology Intake Documentation.

    Science.gov (United States)

    van Leeuwen, Lisette M; Merkus, Paul; Pronk, Marieke; van der Torn, Marein; Maré, Marcel; Goverts, S Theo; Kramer, Sophia E

    The International Classification of Functioning Disability and Health (ICF) Core Sets for Hearing Loss (HL) were developed to serve as a standard for the assessment and reporting of the functioning and health of patients with HL. The aim of the present study was to compare the content of the intake documentation currently used in secondary and tertiary hearing care settings in the Netherlands with the content of the ICF Core Sets for HL. Research questions were (1) to what extent are the ICF Core Sets for HL represented in the Dutch Otology and Audiology intake documentation? (2) are there any extra ICF categories expressed in the intake documentation that are currently not part of the ICF Core Sets for HL, or constructs expressed that are not part of the ICF? Multicenter patient record study including 176 adult patients from two secondary, and two tertiary hearing care settings. The intake documentation was selected from anonymized patient records. The content was linked to the appropriate ICF category from the whole ICF classification using established linking rules. The extent to which the ICF Core Sets for HL were represented in the intake documentation was determined by assessing the overlap between the ICF categories in the Core Sets and the list of unique ICF categories extracted from the intake documentation. Any extra constructs that were expressed in the intake documentation but are not part of the Core Sets were described as well, differentiating between ICF categories that are not part of the Core Sets and constructs that are not part of the ICF classification. In total, otology and audiology intake documentation represented 24 of the 27 Brief ICF Core Set categories (i.e., 89%), and 60 of the 117 Comprehensive ICF Core Set categories (i.e., 51%). Various ICF Core Sets categories were not represented, including higher mental functions (Body Functions), civic life aspects (Activities and Participation), and support and attitudes of family (Environmental

  3. Off-line mapping of multi-rate dependent task sets to many-core platforms

    DEFF Research Database (Denmark)

    Puffitsch, Wolfgang; Noulard, Eric; Pagetti, Claire

    2015-01-01

    This paper presents an approach to execute safety-critical applications on multi- and many-core processors in a predictable manner. We investigate three concrete platforms: the Intel Single-chip Cloud Computer, the Texas Instruments TMS320C6678 and the Tilera TILEmpower-Gx36. We define an execution...... model to safely execute dependent periodic task sets on these platforms. The four rules of the execution model entail that an off-line mapping of the application to the platform must be computed. The paper details our approach to automatically compute a valid mapping. Furthermore, we evaluate our...

  4. Performance Improvement of the Core Protection Calculator System (CPCS) by Introducing Optimal Function Sets

    International Nuclear Information System (INIS)

    Won, Byung Hee; Kim, Kyung O; Kim, Jong Kyung; Kim, Soon Young

    2012-01-01

    The Core Protection Calculator System (CPCS) is an automated device which is adopted to inspect the safety parameters such as Departure from Nuclear Boiling Ratio (DNBR) and Local Power Density (LPD) during normal operation. One function of the CPCS is to predict the axial power distributions using function sets in cubic spline method. Another function of that is to impose penalty when the estimated distribution by the spline method disagrees with embedded data in CPCS (i.e., over 8%). In conventional CPCS, restricted function sets are used to synthesize axial power shape, whereby it occasionally can draw a disagreement between synthesized data and the embedded data. For this reason, the study on improvement for power distributions synthesis in CPCS has been conducted in many countries. In this study, many function sets (more than 18,000 types) differing from the conventional ones were evaluated in each power shape. Matlab code was used for calculating/arranging the numerous cases of function sets. Their synthesis performance was also evaluated through error between conventional data and consequences calculated by new function sets

  5. Towards an ICF core set for ADHD: a worldwide expert survey on ability and disability.

    Science.gov (United States)

    de Schipper, Elles; Mahdi, Soheil; Coghill, David; de Vries, Petrus J; Gau, Susan Shur-Fen; Granlund, Mats; Holtmann, Martin; Karande, Sunil; Levy, Florence; Almodayfer, Omar; Rohde, Luis; Tannock, Rosemary; Bölte, Sven

    2015-12-01

    This is the second in a series of four empirical studies designed to develop International Classification of Functioning, Disability and Health (ICF and Children and Youth version, ICF-CY) core sets for attention deficit hyperactivity disorder (ADHD). The objective of this stage was to gather the opinions from international experts on which ability and disability concepts were considered relevant to functioning in ADHD. An email-based survey was carried out amongst international experts in ADHD. Relevant functional ability and disability concepts were extracted from their responses and linked to the ICF/-CY categories by two independent researchers using a standardised linking procedure. 174 experts from 11 different disciplines and 45 different countries completed the survey. Meaningful concepts identified in their responses were linked to 185 ICF/-CY categories. Of these, 83 categories were identified by at least 5 % of the experts and considered the most relevant to ADHD: 30 of these were related to Body functions (most identified: attention functions, 85 %), 30 to Activities and Participation (most identified: school education, 52 %), 20 to Environmental factors (most identified: support from immediate family, 61 %), and 3 to Body structures (most identified: structure of brain, 83 %). Experts also provided their views on particular abilities related to ADHD, naming characteristics such as high-energy levels, flexibility and resiliency. Gender differences in the expression of ADHD identified by experts pertained mainly to females showing more internalising (e.g. anxiety, low self-esteem) and less externalising behaviours (e.g. hyperactivity), leading to a risk of late- and under-diagnosis in females. Results indicate that the impact of ADHD extends beyond the core symptom domains, into all areas of life and across the lifespan. The current study in combination with three additional preparatory studies (comprehensive scoping review, focus groups, clinical study

  6. Core sets da Classificação Internacional de Funcionalidade, Incapacidade e Saúde

    Directory of Open Access Journals (Sweden)

    Marcelo Riberto

    2011-10-01

    Full Text Available A Classificação Internacional de Funcionalidade, Incapacidade e Saúde (CIF propõe um modelo de entendimento da funcionalidade humana que integra aspectos biomédicos, sociais e pessoais, além de homogeneizar a terminologia que descreve as condições incapacitantes relacionadas à saúde. Todavia, em virtude de sua complexidade e da grande quantidade de aspectos contemplados, foi necessário desenvolver instrumentos práticos baseados nela. Os core sets da CIF são conjuntos de categorias da CIF que descrevem a funcionalidade de pessoas com determinadas condições de saúde. Eles vêm sendo desenvolvidos em processos de consenso com representação multiprofissional e internacional. Os core sets podem ser resumidos ou abrangentes, conforme o uso por apenas um ou mais profissionais. Seu uso permite ao profissional de saúde avaliar aspectos não contemplados por qualquer outro instrumento de avaliação funcional, como os fatores ambientais.

  7. A core outcome set for studies evaluating the effectiveness of prepregnancy care for women with pregestational diabetes.

    LENUS (Irish Health Repository)

    Egan, Aoife M

    2017-04-01

    The aim of this study was to develop a core outcome set (COS) for trials and other studies evaluating the effectiveness of prepregnancy care for women with pregestational (pre-existing) diabetes mellitus.

  8. Improving decision making for massive transfusions in a resource poor setting: a preliminary study in Kenya.

    Directory of Open Access Journals (Sweden)

    Elisabeth D Riviello

    Full Text Available The reality of finite resources has a real-world impact on a patient's ability to receive life-saving care in resource-poor settings. Blood for transfusion is an example of a scarce resource. Very few studies have looked at predictors of survival in patients requiring massive transfusion. We used data from a rural hospital in Kenya to develop a prediction model of survival among patients receiving massive transfusion.Patients who received five or more units of whole blood within 48 hours between 2004 and 2010 were identified from a blood registry in a rural hospital in Kenya. Presenting characteristics and in-hospital survival were collected from charts. Using stepwise selection, a logistic model was developed to predict who would survive with massive transfusion versus those who would die despite transfusion. An ROC curve was created from this model to quantify its predictive power.Ninety-five patients with data available met inclusion criteria, and 74% survived to discharge. The number of units transfused was not a predictor of mortality, and no threshold for futility could be identified. Preliminary results suggest that initial blood pressure, lack of comorbidities, and indication for transfusion are the most important predictors of survival. The ROC curve derived from our model demonstrates an area under the curve (AUC equal to 0.757, with optimism of 0.023 based on a bootstrap validation.This study provides a framework for making prioritization decisions for the use of whole blood in the setting of massive bleeding. Our analysis demonstrated an overall survival rate for patients receiving massive transfusion that was higher than clinical perception. Our analysis also produced a preliminary model to predict survival in patients with massive bleeding. Prediction analyses can contribute to more efficient prioritization decisions; these decisions must also include other considerations such as equity, acceptability, affordability and

  9. Determination of the protection set-points lines for the Angra-1 reactor core

    International Nuclear Information System (INIS)

    Furieri, E.B.

    1980-03-01

    In this work several thermo-hidraulic calculation were performed to obtain Protection set-points lines for the Angra-1 reactor core in order to compare with the values presented by the vendor in the FSAR. These lines are the locus of points where DNBR min = 1,3 and power = 1,18 x P nominal as a function of ΔT m and T m , the temperature difference and the average coolant temperature between hot and cold legs. A computation scheme was developed using COBRA-IIIF as a subroutine of a new main program and adding new subroutines in order to obtain the desired DNBR. The solution is obtained through a convergentce procedure using parameters estimated in a sensivity study. (author) [pt

  10. Developing an OMERACT Core Outcome Set for Assessing Safety Components in Rheumatology Trials

    DEFF Research Database (Denmark)

    Klokker, Louise; Tugwell, Peter; Furst, Daniel E

    2016-01-01

    in such COS. The Outcome Measures in Rheumatology (OMERACT) Filter 2.0 emphasizes the importance of measuring harms. The Safety Working Group was reestablished at the OMERACT 2016 with the objective to develop a COS for assessing safety components in trials across rheumatologic conditions. METHODS: The safety......OBJECTIVE: Failure to report harmful outcomes in clinical research can introduce bias favoring a potentially harmful intervention. While core outcome sets (COS) are available for benefits in randomized controlled trials in many rheumatic conditions, less attention has been paid to safety...... that patients consider relevant so that they will be able to make informed decisions. CONCLUSION: The OMERACT Safety Working Group will advance the work previously done within OMERACT using a new patient-driven approach....

  11. A preliminary feasibility study of passive in-core thermionic reactors for highly compact space nuclear power systems

    International Nuclear Information System (INIS)

    Parlos, A.G.; Khan, E.U.; Frymire, R.; Negron, S.; Thomas, J.K.; Peddicord, K.L.

    1991-01-01

    Results of a preliminary feasibility study on a new concept for a highly compact space reactor power systems are presented. Notwithstanding the preliminary nature of the present study, the results which include a new space reactor configuration and its associated technologies indicate promising avenues for the devleopment of highly compact space reactors. The calculations reported in this study include a neutronic design trade-off study using a two-dimensioinal neutron transport model, as well as a simplified one-dimensional thermal analysis of the reactor core. In arriving at the most desirable configuration, various options have been considered and analyzed, and their advantages/disadvantages have been compared. However, because of space limitation, only the most favorable reactor configuration is presented in this summary

  12. Defining a core outcome set for adolescent and young adult patients with a spinal deformity.

    Science.gov (United States)

    de Kleuver, Marinus; Faraj, Sayf S A; Holewijn, Roderick M; Germscheid, Niccole M; Adobor, Raphael D; Andersen, Mikkel; Tropp, Hans; Dahl, Benny; Keskinen, Heli; Olai, Anders; Polly, David W; van Hooff, Miranda L; Haanstra, Tsjitske M

    2017-12-01

    Background and purpose - Routine outcome measurement has been shown to improve performance in several fields of healthcare. National spine surgery registries have been initiated in 5 Nordic countries. However, there is no agreement on which outcomes are essential to measure for adolescent and young adult patients with a spinal deformity. The aim of this study was to develop a core outcome set (COS) that will facilitate benchmarking within and between the 5 countries of the Nordic Spinal Deformity Society (NSDS) and other registries worldwide. Material and methods - From August 2015 to September 2016, 7 representatives (panelists) of the national spinal surgery registries from each of the NSDS countries participated in a modified Delphi study. With a systematic literature review as a basis and the International Classification of Functioning, Disability and Health framework as guidance, 4 consensus rounds were held. Consensus was defined as agreement between at least 5 of the 7 representatives. Data were analyzed qualitatively and quantitatively. Results - Consensus was reached on the inclusion of 13 core outcome domains: "satisfaction with overall outcome of surgery", "satisfaction with cosmetic result of surgery", "pain interference", physical functioning", "health-related quality of life", "recreation and leisure", "pulmonary fatigue", "change in deformity", "self-image", "pain intensity", "physical function", "complications", and "re-operation". Panelists agreed that the SRS-22r, EQ-5D, and a pulmonary fatigue questionnaire (yet to be developed) are the most appropriate set of patient-reported measurement instruments that cover these outcome domains. Interpretation - We have identified a COS for a large subgroup of spinal deformity patients for implementation and validation in the NSDS countries. This is the first study to further develop a COS in a global perspective.

  13. An Algorithm for Glaucoma Screening in Clinical Settings and Its Preliminary Performance Profile

    Directory of Open Access Journals (Sweden)

    S-Farzad Mohammadi

    2013-01-01

    Full Text Available Purpose: To devise and evaluate a screening algorithm for glaucoma in clinical settings. Methods: Screening included examination of the optic disc for vertical cupping (≥0.4 and asymmetry (≥0.15, Goldmann applanation tonometry (≥21 mmHg, adjusted or unadjusted for central corneal thickness, and automated perimetry. In the diagnostic step, retinal nerve fiber layer imaging was performed using scanning laser polarimetry. Performance of the screening protocol was assessed in an eye hospital-based program in which 124 non-physician personnel aged 40 years or above were examined. A single ophthalmologist carried out the examinations and in equivocal cases, a glaucoma subspecialist′s opinion was sought. Results: Glaucoma was diagnosed in six cases (prevalence 4.8%; 95% confidence interval, 0.01-0.09 of whom five were new. The likelihood of making a definite diagnosis of glaucoma for those who were screened positively was 8.5 times higher than the estimated baseline risk for the reference population; the positive predictive value of the screening protocol was 30%. Screening excluded 80% of the initial population. Conclusion: Application of a formal screening protocol (such as our algorithm or its equivalent in clinical settings can be helpful in detecting new cases of glaucoma. Preliminary performance assessment of the algorithm showed its applicability and effectiveness in detecting glaucoma among subjects without any visual complaint.

  14. Identification of a core set of rhizobial infection genes using data from single cell-types

    Directory of Open Access Journals (Sweden)

    Da-Song eChen

    2015-07-01

    Full Text Available Genome-wide expression studies on nodulation have varied in their scale from entire root systems to dissected nodules or root sections containing nodule primordia. More recently efforts have focused on developing methods for isolation of root hairs from infected plants and the application of laser-capture microdissection technology to nodules. Here we analyze two published data sets to identify a core set of infection genes that are expressed in the nodule and in root hairs during infection. Among the genes identified were those encoding phenylpropanoid biosynthesis enzymes including Chalcone-O-Methyltransferase which is required for the production of the potent Nod gene inducer 4’,4-dihydroxy-2-methoxychalcone. A promoter-GUS analysis in transgenic hairy roots for two genes encoding Chalcone-O-Methyltransferase isoforms revealed their expression in rhizobially infected root hairs and the nodule infection zone but not in the nitrogen fixation zone. We also describe a group of Rhizobially Induced Peroxidases whose expression overlaps with the production of superoxide in rhizobially infected root hairs and in nodules and roots. Finally, we identify a cohort of co-regulated transcription factors as candidate regulators of these processes.

  15. Preliminary analysis of a large 1600 MWe PWR core loaded with 30% MOX fuel

    International Nuclear Information System (INIS)

    Polidoro, Franco; Corsetti, Edoardo; Vimercati, Giuliano

    2011-01-01

    The paper presents a full-core 3-D analysis of the performances of a large 1600 MWe PWR core, loaded with 30% MOX fuel, in accordance with the European Utility Requirements (EUR). These requirements state that the European next generation power plants have to be designed capable to use MOX (UO 2 - PuO 2 ) fuel assemblies up to 50% of the core, together with UO 2 fuel assemblies. The use of MOX assemblies has a significant impact on key physic parameters and on safety. A lot of studies have been carried out in the past to explore the feasibility of plutonium recycling strategies by loading LWR reactors with MOX fuel. Many of these works were based on lattice codes, in order to perform detailed analyses of the neutronic characteristics of MOX assemblies. With the aim to take into account their interaction with surrounding UO 2 fuel elements, and the global effects on the core at operational conditions, an integrated approach making use of a 3-D core simulation is required. In this light, the present study adopts the state-of-art numerical models CASMO-5 and SIMULATE-3 to analyze the behavior of the core fueled with 30% MOX and to compare it with that of a large PWR reference core, fueled with UO 2 . (author)

  16. A Preliminary Design Study of Ultra-Long-Life SFR Cores having Heterogeneous Fuel Assemblies

    Energy Technology Data Exchange (ETDEWEB)

    Jung, GeonHee; You, WuSeung; Hong, Ser Gi [Kyung Hee University, Yongin (Korea, Republic of)

    2016-10-15

    The PWR and CANDU reactors have provided electricity for several decades in our country but they have produced lots of spent fuels and so the safe and efficient disposal of these spent fuels is one of the main issues in nuclear industry. This type ultra-long-life cores are quite efficient in terms of the amount of spent fuel generation per electricity production and they can be used as an interim storage for PWR or CANDU spent fuel over several tens of years if they use the PWR or CANDU spent fuel as the initial fuel. Typically, the previous works have considered radially homogeneous fuel assemblies in which only blanket or driver fuel rods are employed and they considered axially or radially heterogeneous core configurations with the radially homogeneous fuel assemblies. These core configurations result in the propagation of the power distribution which can lead to the significant temperature changes for each fuel assembly over the time. In this work, the radially heterogeneous fuel assemblies are employed in new ultra-long-life SFR (Sodium-cooled Fast Reactor) cores to minimize the propagation of power distribution by allowing the power propagation in the fuel assemblies. In this work, new small ultra-long life SFR cores were designed with heterogeneous fuel assemblies having both blanket and driver fuel rods to minimize the propagation of power distribution over the core by allowing power propagation from driver rods to blanket rods in fuel assemblies. In particular, high fidelity depletion calculation coupled with heterogeneous Monte Carlo neutron transport calculation was performed to assess the neutronic feasibility of the ultralong life cores. The results of the analysis showed that the candidate core has the cycle length of 77 EFPYs, a small burnup reactivity swing of 1590 pcm and acceptably small SVRs both at BOC and EOC.

  17. Structures of glide-set 90 deg. partial dislocation cores in diamond cubic semiconductors

    International Nuclear Information System (INIS)

    Beckman, S.P.; Chrzan, D.C.

    2003-01-01

    Two core reconstructions of the 90 deg. partial dislocations in diamond cubic semiconductors, the so-called single- and double-period structures, are often found to be nearly degenerate in energy. This near degeneracy suggests the possibility that both core reconstructions may be present simultaneously along the same dislocation core, with the domain sizes of the competing reconstructions dependent on temperature and the local stress state. To explore this dependence, a simple statistical mechanics-based model of the dislocation core reconstructions is developed and analyzed. Predictions for the temperature-dependent structure of the dislocation core are presented

  18. Mapping of a standard documentation template to the ICF core sets for arthritis and low back pain.

    Science.gov (United States)

    Escorpizo, Reuben; Davis, Kandace; Stumbo, Teri

    2010-12-01

    To identify the contents of a documentation template in The Guide to Physical Therapist Practice using the International Classification of Functioning, Disability, and Health (ICF) Core Sets for rheumatoid arthritis, osteoarthritis, and low back pain (LBP) as reference. Concepts were identified from items of an outpatient documentation template and mapped to the ICF using established linking rules. The ICF categories that were linked were compared with existing arthritis and LBP Core Sets. Based on the ICF, the template had the highest number (29%) of linked categories under Activities and participation while Body structures had the least (17%). ICF categories in the arthritis and LBP Core Sets had a 37-55% match with the ICF categories found in the template. We found 164 concepts that were not classified or not defined and 37 as personal factors. The arthritis and LBP Core Sets were reflected in the contents of the template. ICF categories in the Core Sets were reflected in the template (demonstrating up to 55% match). Potential integration of ICF in documentation templates could be explored and examined in the future to enhance clinical encounters and multidisciplinary communication. Copyright © 2010 John Wiley & Sons, Ltd.

  19. Offending by people with intellectual disabilities in community settings: a preliminary examination of contextual factors.

    Science.gov (United States)

    Wheeler, Jessica R; Clare, Isabel C H; Holland, Anthony J

    2013-09-01

    While several validated measures of the life circumstances of people with intellectual disabilities (ID) have been developed, this stream of research has not yet been well integrated with environmentally oriented criminological theory to explain offending among people with ID. In this study, we attempt to provide a preliminary integration through an investigation of the relationship between contemporary life experiences, well-being, choice and offending among people with ID, exploring the relevance of two classic criminological theories (theories of strain and social control). Questionnaire measures were used to compare a range of 'ordinary' life experiences [the 'Life Experiences Checklist' (LEC)], subjective well-being (the 'Personal Well-being Index - ID') and the extent of choice (the 'Choice Questionnaire'), between offenders (N = 27) and non-offenders (N = 19) with ID recruited through integrated (NHS and Local Authority) multi-disciplinary teams (community teams for adults with learning disabilities). Using regression analyses to explore the strength of associations with offending, it was found that an indicator of impoverished personal relationships, from the LEC provided the best predictor of offending. This finding appears to favour criminological explanations based on social control. Existing measures of life circumstances can be used to explore environmentally oriented criminological theories, bringing benefits to our understanding and treatment of offenders with ID living in community settings. © 2013 John Wiley & Sons Ltd.

  20. New large solar photocatalytic plant: set-up and preliminary results.

    Science.gov (United States)

    Malato, S; Blanco, J; Vidal, A; Fernández, P; Cáceres, J; Trincado, P; Oliveira, J C; Vincent, M

    2002-04-01

    A European industrial consortium called SOLARDETOX has been created as the result of an EC-DGXII BRITE-EURAM-III-financed project on solar photocatalytic detoxification of water. The project objective was to develop a simple, efficient and commercially competitive water-treatment technology, based on compound parabolic collectors (CPCs) solar collectors and TiO2 photocatalysis, to make possible easy design and installation. The design, set-up and preliminary results of the main project deliverable, the first European industrial solar detoxification treatment plant, is presented. This plant has been designed for the batch treatment of 2 m3 of water with a 100 m2 collector-aperture area and aqueous aerated suspensions of polycrystalline TiO2 irradiated by sunlight. Fully automatic control reduces operation and maintenance manpower. Plant behaviour has been compared (using dichloroacetic acid and cyanide at 50 mg l(-1) initial concentration as model compounds) with the small CPC pilot plants installed at the Plataforma Solar de Almería several years ago. The first results with high-content cyanide (1 g l(-1)) waste water are presented and plant treatment capacity is calculated.

  1. Preliminary stratigraphic and petrologic characterization of core samples from USW-G1, Yucca Mountain, Nevada

    International Nuclear Information System (INIS)

    Waters, A.C.; Carroll, P.R.

    1981-11-01

    Tuffs of the Nevada Test Site are currently under investigation to determine their potential for long-term storage of radioactive waste. As part of this program, hole USW-G1 was drilled to a depth of 6000 ft below the surface, in the central part of the Yucca Mountain area, Nevada Test Site, Nevada. Petrographic study of the USW-G1 core is presented in this report and shows the tuffs (which generally were variably welded ash flows) are partly recrystallized to a variety of secondary minerals. The important alteration products are zeolites (heulandite, clinoptilolite, mordenite and analcime), smectite clays with minor interstratified illite, albite, micas, potassium feldspar, and various forms of silica. Iijima's zeolite zones I through IV of burial metamorphism can be recognized in the core. Zeolites are first observed at about the 1300-ft depth, and the high-temperature boundary of zeolite stability in this core occurs at about 4350 ft. Analcime persists, either metastably or as a retrograde mineral, deeper in the core. The oxidation state of Fe-Ti oxide minerals, through most of the core, increases as the degree of welding decreases, but towards the bottom of the hole, reducing conditions generally prevail. Four stratigraphic units transected by the core may be potentially favorable sites for a waste repository. These four units, in order of increasing depth in the core, are (1) the lower cooling unit of the Topopah Spring Member, (2) cooling unit II of the Bullfrog Member, (3) the upper part of the Tram tuff, and (4) the Lithic-rich tuff

  2. Preliminary stratigraphic and petrologic characterization of core samples from USW-G1, Yucca Mountain, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Waters, A.C.; Carroll, P.R. (eds.)

    1981-11-01

    Tuffs of the Nevada Test Site are currently under investigation to determine their potential for long-term storage of radioactive waste. As part of this program, hole USW-G1 was drilled to a depth of 6000 ft below the surface, in the central part of the Yucca Mountain area, Nevada Test Site, Nevada. Petrographic study of the USW-G1 core is presented in this report and shows the tuffs (which generally were variably welded ash flows) are partly recrystallized to a variety of secondary minerals. The important alteration products are zeolites (heulandite, clinoptilolite, mordenite and analcime), smectite clays with minor interstratified illite, albite, micas, potassium feldspar, and various forms of silica. Iijima`s zeolite zones I through IV of burial metamorphism can be recognized in the core. Zeolites are first observed at about the 1300-ft depth, and the high-temperature boundary of zeolite stability in this core occurs at about 4350 ft. Analcime persists, either metastably or as a retrograde mineral, deeper in the core. The oxidation state of Fe-Ti oxide minerals, through most of the core, increases as the degree of welding decreases, but towards the bottom of the hole, reducing conditions generally prevail. Four stratigraphic units transected by the core may be potentially favorable sites for a waste repository. These four units, in order of increasing depth in the core, are (1) the lower cooling unit of the Topopah Spring Member, (2) cooling unit II of the Bullfrog Member, (3) the upper part of the Tram tuff, and (4) the Lithic-rich tuff.

  3. Setting up a new CZO in the Ganga basin: instrumentation, stakeholder engagement and preliminary observations

    Science.gov (United States)

    Gupta, S.; Tripathi, S.; Sinha, R.; Karumanchi, S. H.; Paul, D.; Tripathi, S. N.; Sen, I. S.; Dash, S. K.

    2017-12-01

    The Ganga plains represent the abode of more than 400 million people and a region of severe anthropogenic disturbance to natural processes. Changing agricultural practices, inefficient use of water, contamination of groundwater systems, and decrease in soil fertility are some of the issues that have affected the long-term resilience of hydrological processes. The quantification of these processes demands a network of hydro-meteorological instrumentation, low-cost sensors, continuous engagement of stakeholders and real time data transmission at a fine interval. We have therefore set up a Critical Zone Observatory (CZO) in a small watershed (35km2) that forms an intensively managed rural landscape consisting of 92% of agricultural land in the Pandu River Basin (a small tributary of the Ganga River). Apart from setting up a hydro-meteorological observatory, the major science questions we want to address relate to development of water balance model, understanding the soil-water interaction and estimation of nutrient fluxes in the watershed. This observatory currently has various types of sensors that are divided into three categories: (a) spatially not dense but temporally fine data, (b) spatially dense but temporally not fine data and(c) spatially dense and temporally fine data. The first category represent high-cost sensors namely automatic weather stations that are deployed at two locations and provide data at 15-minute interval. The second category includes portable soil moisture, discharge and groundwater level at weekly/ biweekly interval. The third category comprises low-cost sensors including automatic surface and groundwater level sensors installed on open wells to monitor the continuous fluctuation of water level at every 15 minutes. In addition to involving the local communities in data collection (e.g. manual rainfall measurement, water and soil sampling), this CZO also aims to provide relevant information to them for improving their sustainability. The

  4. Setting up and functioning of an Emergency Medicine Department: Lessons learned from a preliminary study

    Directory of Open Access Journals (Sweden)

    K Asish

    2016-01-01

    Full Text Available Background and Aims: Tertiary care teaching hospitals remain referral centres for victims of trauma and mass casualty. Often specialists from various disciplines manage these crowded casualty areas. These age old casualty areas are being replaced, throughout the country by Emergency Medicine Departments (EMDs, presumed to be better planned to confront a crisis. We aimed to gather basic data contributive in setting up of an EMD at a tertiary care teaching hospital from the lessons learned from functioning existent systems. Methods: This is primarily a questionnaire-based descriptive study at tertiary care referral centres across the country, which was purposively selected.The study models included one from a hospital without designated EMD and the other four from hospitals with established EMDs. Direct observation and focus group meetings with experienced informants at these hospitals contributed to the data. In the absence of a validated hospital preparedness assessment scale, comparison was done with regard to quantitative, qualitative and corroborative parameters using descriptive analysis. Results: The EMDs at best practice models were headed by specialist in Emergency Medicine assisted by organised staff, had protocols for managing mass casualty incident (MCI, separate trauma teams, ergonomic use of infrastructure and public education programmes. In this regard, these hospitals seemed well organised to manage MCIs and disasters. Conclusion: The observation may provide a preliminary data useful in setting up an EMD. In the absence of published Indian literature, this may facilitate further research in this direction. Anaesthesiologists, presently an approved Faculty in Emergency Medicine training can provide creative input with regard to its initial organisation and functioning, thus widening our horizons in a country where there is a severe dearth of trained emergency physicians.

  5. Improvement of the Cubic Spline Function Sets for a Synthesis of the Axial Power Distribution of a Core Protection System

    International Nuclear Information System (INIS)

    Koo, Bon-Seung; Lee, Chung-Chan; Zee, Sung-Quun

    2006-01-01

    Online digital core protection system(SCOPS) for a system-integrated modular reactor is being developed as a part of a plant protection system at KAERI. SCOPS calculates the minimum CHFR and maximum LPD based on several online measured system parameters including 3-level ex-core detector signals. In conventional ABB-CE digital power plants, cubic spline synthesis technique has been used in online calculations of the core axial power distributions using ex-core detector signals once every 1 second in CPC. In CPC, pre-determined cubic spline function sets are used depending on the characteristics of the ex-core detector responses. But this method shows an unnegligible power distribution error for the extremely skewed axial shapes by using restrictive function sets. Therefore, this paper describes the cubic spline method for the synthesis of an axial power distribution and it generates several new cubic spline function sets for the application of the core protection system, especially for the severely distorted power shapes needed reactor type

  6. Citation analysis did not provide a reliable assessment of core outcome set uptake.

    Science.gov (United States)

    Barnes, Karen L; Kirkham, Jamie J; Clarke, Mike; Williamson, Paula R

    2017-06-01

    The aim of the study was to evaluate citation analysis as an approach to measuring core outcome set (COS) uptake, by assessing whether the number of citations for a COS report could be used as a surrogate measure of uptake of the COS by clinical trialists. Citation data were obtained for COS reports published before 2010 in five disease areas (systemic sclerosis, rheumatoid arthritis, eczema, sepsis and critical care, and female sexual dysfunction). Those publications identified as a report of a clinical trial were examined to identify whether or not all outcomes in the COS were measured in the trial. Clinical trials measuring the relevant COS made up a small proportion of the total number of citations for COS reports. Not all trials citing a COS report measured all the recommended outcomes. Some trials cited the COS reports for other reasons, including the definition of a condition or other trial design issues addressed by the COS report. Although citation data can be readily accessed, it should not be assumed that the citing of a COS report indicates that a trial has measured the recommended COS. Alternative methods for assessing COS uptake are needed. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  7. A Core Set Based Large Vector-Angular Region and Margin Approach for Novelty Detection

    Directory of Open Access Journals (Sweden)

    Jiusheng Chen

    2016-01-01

    Full Text Available A large vector-angular region and margin (LARM approach is presented for novelty detection based on imbalanced data. The key idea is to construct the largest vector-angular region in the feature space to separate normal training patterns; meanwhile, maximize the vector-angular margin between the surface of this optimal vector-angular region and abnormal training patterns. In order to improve the generalization performance of LARM, the vector-angular distribution is optimized by maximizing the vector-angular mean and minimizing the vector-angular variance, which separates the normal and abnormal examples well. However, the inherent computation of quadratic programming (QP solver takes O(n3 training time and at least O(n2 space, which might be computational prohibitive for large scale problems. By (1+ε  and  (1-ε-approximation algorithm, the core set based LARM algorithm is proposed for fast training LARM problem. Experimental results based on imbalanced datasets have validated the favorable efficiency of the proposed approach in novelty detection.

  8. Development of a core outcome set for clinical trials in facial aging: study protocol for a systematic review of the literature and identification of a core outcome set using a Delphi survey.

    Science.gov (United States)

    Schlessinger, Daniel I; Iyengar, Sanjana; Yanes, Arianna F; Henley, Jill K; Ashchyan, Hovik J; Kurta, Anastasia O; Patel, Payal M; Sheikh, Umar A; Franklin, Matthew J; Hanna, Courtney C; Chen, Brian R; Chiren, Sarah G; Schmitt, Jochen; Deckert, Stefanie; Furlan, Karina C; Poon, Emily; Maher, Ian A; Cartee, Todd V; Sobanko, Joseph F; Alam, Murad

    2017-08-01

    Facial aging is a concern for many patients. Wrinkles, loss of volume, and discoloration are common physical manifestations of aging skin. Genetic heritage, prior ultraviolet light exposure, and Fitzpatrick skin type may be associated with the rate and type of facial aging. Although many clinical trials assess the correlates of skin aging, there is heterogeneity in the outcomes assessed, which limits the quality of evaluation and comparison of treatment modalities. To address the inconsistency in outcomes, in this project we will develop a core set of outcomes that are to be evaluated in all clinical trials relevant to facial aging. A long list of measureable outcomes will be created from four sources: (1) systematic medical literature review, (2) patient interviews, (3) other published sources, and (4) stakeholder involvement. Two rounds of Delphi processes with homogeneous groups of physicians and patients will be performed to prioritize and condense the list. At a consensus meeting attended by physicians, patients, and stakeholders, outcomes will be further condensed on the basis of participant scores. By the end of the meeting, members will vote and decide on a final recommended set of core outcomes. Subsequent to this, specific measures will be selected or created to assess these outcomes. The aim of this study is to develop a core outcome set and relevant measures for clinical trials relevant to facial aging. We hope to improve the reliability and consistency of outcome reporting of skin aging, thereby enabling improved evaluation of treatment efficacy and patient satisfaction. Core Outcome Measures in Effectiveness Trials (COMET) Initiative, accessible at http://www.comet-initiative.org/studies/details/737 . Core Outcomes Set Initiative, (CSG-COUSIN) accessible at https://www.uniklinikum-dresden.de/de/das-klinikum/universitaetscentren/zegv/cousin/meet-the-teams/project-groups/core-outcome-set-for-the-appearance-of-facial-aging . Protocol version date is 28

  9. Preliminary investigations of a mixed standard-flip core for a TRIGA Mark II

    International Nuclear Information System (INIS)

    Ringle, John C.; Johnson, A.G.; Anderson, T.V.

    1974-01-01

    Several years ago it became apparent that due to our rapidly- increasing use rate, we would need a substantial amount of new fuel by late 1974 or early 1975. After investigations and discussions with GA, we decided that FLIP fuel would best meet our requirements for maximum fuel economy and high peak pulsing power. A proposal was submitted to the AEC for fuel assistance, and late in 1973 we were awarded a grant of $61,875. This will allow us to buy 3 FLIP-fueled-follower control rods, 1 instrumented FLIP fuel element, and 26 standard FLIP elements, giving us then a mixed core of approximately one-third FLIP and two-thirds standard elements. License amendments to accommodate this change are rather straightforward; modifications to the Technical Specifications will be somewhat more involved. The largest revisions which we envision are to our Safety Analysis Report. Although a few reactors have operated with a full FLIP core, and a few others have converted to mixed standard-FLIP cores, none of these has a standard Mark II core configuration. Those who have already converted to a mixed core have data and calculations which may be helpful to us, but the extent to which we can use these remains to be seen. The present status of our investigations into the analysis of a mixed standard-FLIP core will be presented. Any problems in calculational methods, finding appropriate data, modifications to Technical Specifications, etc., will be identified, and suggestions and help in these areas will be welcomed. (author)

  10. Preliminary investigations of a mixed standard-flip core for a TRIGA Mark II

    Energy Technology Data Exchange (ETDEWEB)

    Ringle, John C; Johnson, A G; Anderson, T V [Oregon State University (United States)

    1974-07-01

    Several years ago it became apparent that due to our rapidly- increasing use rate, we would need a substantial amount of new fuel by late 1974 or early 1975. After investigations and discussions with GA, we decided that FLIP fuel would best meet our requirements for maximum fuel economy and high peak pulsing power. A proposal was submitted to the AEC for fuel assistance, and late in 1973 we were awarded a grant of $61,875. This will allow us to buy 3 FLIP-fueled-follower control rods, 1 instrumented FLIP fuel element, and 26 standard FLIP elements, giving us then a mixed core of approximately one-third FLIP and two-thirds standard elements. License amendments to accommodate this change are rather straightforward; modifications to the Technical Specifications will be somewhat more involved. The largest revisions which we envision are to our Safety Analysis Report. Although a few reactors have operated with a full FLIP core, and a few others have converted to mixed standard-FLIP cores, none of these has a standard Mark II core configuration. Those who have already converted to a mixed core have data and calculations which may be helpful to us, but the extent to which we can use these remains to be seen. The present status of our investigations into the analysis of a mixed standard-FLIP core will be presented. Any problems in calculational methods, finding appropriate data, modifications to Technical Specifications, etc., will be identified, and suggestions and help in these areas will be welcomed. (author)

  11. YOUNG STARLESS CORES EMBEDDED IN THE MAGNETICALLY DOMINATED PIPE NEBULA. II. EXTENDED DATA SET

    International Nuclear Information System (INIS)

    Frau, P.; Girart, J. M.; Padovani, M.; Beltrán, M. T.; Sánchez-Monge, Á.; Busquet, G.; Morata, O.; Masqué, J. M.; Estalella, R.; Alves, F. O.; Franco, G. A. P.

    2012-01-01

    The Pipe nebula is a massive, nearby, filamentary dark molecular cloud with a low star formation efficiency threaded by a uniform magnetic field perpendicular to its main axis. It harbors more than a hundred, mostly quiescent, very chemically young starless cores. The cloud is therefore a good laboratory to study the earliest stages of the star formation process. We aim to investigate the primordial conditions and the relation among physical, chemical, and magnetic properties in the evolution of low-mass starless cores. We used the IRAM 30 m telescope to map the 1.2 mm dust continuum emission of five new starless cores, which are in good agreement with previous visual extinction maps. For the sample of nine cores, which includes the four cores studied in a previous work, we derived an A V to N H 2 factor of (1.27 ± 0.12) × 10 –21 mag cm 2 and a background visual extinction of ∼6.7 mag possibly arising from the cloud material. We derived an average core diameter of ∼0.08 pc, density of ∼10 5 cm –3 , and mass of ∼1.7 M ☉ . Several trends seem to exist related to increasing core density: (1) the diameter seems to shrink, (2) the mass seems to increase, and (3) the chemistry tends to be richer. No correlation is found between the direction of the surrounding diffuse medium magnetic field and the projected orientation of the cores, suggesting that large-scale magnetic fields seem to play a secondary role in shaping the cores. We also used the IRAM 30 m telescope to extend the previous molecular survey at 1 and 3 mm of early- and late-time molecules toward the same five new Pipe nebula starless cores, and analyzed the normalized intensities of the detected molecular transitions. We confirmed the chemical differentiation toward the sample and increased the number of molecular transitions of the 'diffuse' (e.g., the 'ubiquitous' CO, C 2 H, and CS), 'oxo-sulfurated' (e.g., SO and CH 3 OH), and 'deuterated' (e.g., N 2 H + , CN, and HCN) starless core groups

  12. Prediction of core and lower extremity strains and sprains in collegiate football players: a preliminary study.

    Science.gov (United States)

    Wilkerson, Gary B; Giles, Jessica L; Seibel, Dustin K

    2012-01-01

    Poor core stability is believed to increase vulnerability to uncontrolled joint displacements throughout the kinetic chain between the foot and the lumbar spine. To assess the value of preparticipation measurements as predictors of core or lower extremity strains or sprains in collegiate football players. Cohort study. National Collegiate Athletic Association Division I Football Championship Subdivision football program. All team members who were present for a mandatory physical examination on the day before preseason practice sessions began (n = 83). Preparticipation administration of surveys to assess low back, knee, and ankle function; documentation of knee and ankle injury history; determination of body mass index; 4 different assessments of core muscle endurance; and measurement of step-test recovery heart rate. All injuries were documented throughout the preseason practice period and 11-game season. Receiver operating characteristic analysis and logistic regression analysis were used to identify dichotomized predictive factors that best discriminated injured from uninjured status. The 75th and 50th percentiles were evaluated as alternative cutpoints for dichotomization of injury predictors. Players with ≥2 of 3 potentially modifiable risk factors related to core function had 2 times greater risk for injury than those with football injury risk factors that can be identified on preparticipation screening. These predictors need to be assessed in a prospective manner with a larger sample of collegiate football players.

  13. Preliminary Physical Stratigraphy and Geophysical Data From the USGS Dixon Core, Onslow County, North Carolina

    Science.gov (United States)

    Seefelt, Ellen L.; Gonzalez, Wilma Aleman B.; Self-Trail, Jean M.; Weems, Robert E.; Edwards, Lucy E.; Pierce, Herbert A.; Durand, Colleen T.

    2009-01-01

    In October through November 2006, scientists from the U. S. Geological Survey (USGS) Eastern Region Earth Surface Processes Team (EESPT) and the Raleigh (N.C.) Water Science Center (WSC), in cooperation with the North Carolina Geological Survey (NCGS) and the Onslow County Water and Sewer Authority (ONWASA), drilled a stratigraphic test hole and well in Onslow County, N.C. The Dixon corehole was cored on ONWASA water utility property north of the town of Dixon, N.C., in the Sneads Ferry 7.5-minute quadrangle at latitude 34deg33'35' N, longitude 77deg26'54' W (decimal degrees 34.559722 and -77.448333). The site elevation is 66.0 feet (ft) above mean sea level as determined using a Paulin precision altimeter. The corehole attained a total depth of 1,010 ft and was continuously cored by the USGS EESPT drilling crew. A groundwater monitoring well was installed in the screened interval between 234 and 254 ft below land surface. The section cored at this site includes Upper Cretaceous, Paleogene, and Neogene sediments. The Dixon core is stored at the NCGS Coastal Plain core storage facility in Raleigh. The Dixon corehole is the fourth and last in a series of planned North Carolina benchmark coreholes drilled by the USGS Coastal Carolina Project. These coreholes explore the physical stratigraphy, facies, and thickness of Cretaceous, Paleogene, and Neogene Coastal Plain sediments in North Carolina. Correlations of lithologies, facies, and sequence stratigraphy can be made with the Hope Plantation corehole, N.C., near Windsor in Bertie County (Weems and others, 2007); the Elizabethtown corehole, near Elizabethtown, N.C., in Bladen County (Self-Trail and others, 2004b); the Smith Elementary School corehole, near Cove City, N.C., in Craven County (Harris and Self-Trail, 2006; Crocetti, 2007); the Kure Beach corehole, near Wilmington, N.C., in New Hanover County (Self-Trail and others, 2004a); the Esso#1, Esso #2, Mobil #1, and Mobil #2 cores in Albermarle and Pamlico Sounds

  14. The use of qualitative methods to inform Delphi surveys in core outcome set development.

    Science.gov (United States)

    Keeley, T; Williamson, P; Callery, P; Jones, L L; Mathers, J; Jones, J; Young, B; Calvert, M

    2016-05-04

    Core outcome sets (COS) help to minimise bias in trials and facilitate evidence synthesis. Delphi surveys are increasingly being used as part of a wider process to reach consensus about what outcomes should be included in a COS. Qualitative research can be used to inform the development of Delphi surveys. This is an advance in the field of COS development and one which is potentially valuable; however, little guidance exists for COS developers on how best to use qualitative methods and what the challenges are. This paper aims to provide early guidance on the potential role and contribution of qualitative research in this area. We hope the ideas we present will be challenged, critiqued and built upon by others exploring the role of qualitative research in COS development. This paper draws upon the experiences of using qualitative methods in the pre-Delphi stage of the development of three different COS. Using these studies as examples, we identify some of the ways that qualitative research might contribute to COS development, the challenges in using such methods and areas where future research is required. Qualitative research can help to identify what outcomes are important to stakeholders; facilitate understanding of why some outcomes may be more important than others, determine the scope of outcomes; identify appropriate language for use in the Delphi survey and inform comparisons between stakeholder data and other sources, such as systematic reviews. Developers need to consider a number of methodological points when using qualitative research: specifically, which stakeholders to involve, how to sample participants, which data collection methods are most appropriate, how to consider outcomes with stakeholders and how to analyse these data. A number of areas for future research are identified. Qualitative research has the potential to increase the research community's confidence in COS, although this will be dependent upon using rigorous and appropriate

  15. A Preliminary Study of the Core Catcher System on Various Stud Shapes using FLUENT

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Uiju; Seo, Gwang Hyeok; Jeun, Gyoodong; Kim, Sung Joong [Hanyang University, Seoul (Korea, Republic of)

    2014-10-15

    As a kind of in-vessel retention (IVR) strategies, reactor cavity flooding is used for Westinghouse's AP1000 and South Korea's OPR1000. Moreover, the European Pressurized Reactor (EPR) has adopted an ex-vessel core catcher strategy rather than the IVR strategy. Although the mitigation strategies suggested are vigorously considered, there are still various issues due to its uncertainties and complex phenomena during severe accidents. In this study, to assess the effect of studs installed on the core catcher body, a CFD analysis for coolant channels having rectangular or cylinder shaped studs is carried out. In this study, numerical simulations for the different stud shapes of the core catcher system were carried out using ANSYS FLUENT. For a comparison work, the rectangular and cylinder shaped stud were modeled with the same initial and boundary conditions. The major findings observed from this study can be summarized as follows. - The simulation results showed the 31% reduced amount of pressure drop for the case of the cylinder shaped studs as compared with the reference case, which is for the rectangular studs. - The tendency of reduced pressure drop is well in accord with the flow distribution. The fluid velocities around the studs were greatly distorted for the rectangular studs than those around the cylinder studs. - The distorted stream of fluid could affect heat transfer from core catcher body, and result in locally additional damages. This result may suggest the necessity of finding an optimized stud shape. For more improved comparison work, an additional simulation is planned including different stud shapes.

  16. Preliminary petrographic and geophysical interpretations of the exploratory geothermal drill hole and core, Redstone, New Hampshire

    Energy Technology Data Exchange (ETDEWEB)

    Hoag, R.B. Jr.; Stewart, G.W.

    1977-06-30

    A 3000 foot diamond drill hole was drilled in the Conway Granite in Redstone, New Hampshire. A comprehensive detailed petrographic and physical study of this core was made. The purpose of this study is to supply a sound data base for future geothermal and uranium-thorium studies of the drill core. An estimate of the heat flow potential of the Redstone drill hole gives a heat flow of 1.9 HFU. If only the red phase of the Conway Granite had been intersected the heat flow may have been as much as 2.7 HFU, reaching a temperature of 260/sup 0/C at 6 km. The drill hole intersected four lithologies; the green and red phase of the Conway Granite, the Albany quartz syenite and a medium-grained, hastingsite-biotite granite. The red phase has the highest and most irregular radioactivity. The irregularity is mainly due to minor variations in lithology. The drill core intersected several alteration zones up to a thickness of 150 feet. These alteration zones represent passage of low to medium temperature fluids which might have been mineralized. The Conway Granite has the physical and chemical characteristics necessary for the formation of vein type uranium deposits. The presence of unexplained radiometric anomalies lends support to the existence of such deposits.

  17. Materials considerations for UF6 gas-core reactor. Interim report for preliminary design study

    International Nuclear Information System (INIS)

    Wagner, P.

    1977-04-01

    The limiting materials problem in a high-temperature UF 6 core reactor is the corrosion of the core containment vessel. The UF 6 , the lower fluorides of uranium, and the fluorine that exist at the anticipated reactor operating conditions (1000 K and about one atmosphere UF 6 ) are all corrosive. Because of this, the materials evaluation effort for this reactor design study has concentrated on the identification of a viable system for the containment vessel that meets both the materials and neutronic requirements. A study of the literature has revealed that the most promising corrosion-resistant candidates are Ni or Ni-Al alloys. One of the conclusions of this work is that the containment vessel use a nickel liner or clad since the use of Ni as a structural member is precluded by its relative blackness to thermal neutrons. Estimates of corrosion rates of Ni and Ni-Al alloys, the effects of the pressure and temperature of F 2 on the corrosion rates, calculated equilibrium gas compositions at reactor core operating conditions, suggested methods of fabrication, and recommendations for future research and development are included

  18. Validating Mobile Electroencephalographic Systems for Integration into the PhyCORE and Application in Clinical Settings

    Science.gov (United States)

    2016-09-26

    Systems for PhyCORE 5 Table 1. Technical Features of the Mobile EEG Systems WS ABM ANT Sensor Type Active dry sensors Gel on absorbent foam Gel on...unique methods for achieving mobility and synchronizing external events with the EEG signals. As depicted in Figure 5, for the ABM system , EEG signals...This method effectively eliminated the Tblue found with the ABM system . D-Flow commands WS ANT PhyCORE PhyCORE Control Center ABM t2 Amplifier

  19. 75 FR 82397 - Medicaid Program: Initial Core Set of Health Quality Measures for Medicaid-Eligible Adults

    Science.gov (United States)

    2010-12-30

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Office of the Secretary [CMS-2420-NC] Medicaid Program: Initial Core Set of Health Quality Measures for Medicaid-Eligible Adults AGENCY: Office of the Secretary... quality measures recommended for Medicaid-eligible adults, as required by section 2701 of the Affordable...

  20. Low Back Pain in 17 Countries, a Rasch Analysis of the ICF Core Set for Low Back Pain

    Science.gov (United States)

    Roe, Cecilie; Bautz-Holter, Erik; Cieza, Alarcos

    2013-01-01

    Previous studies indicate that a worldwide measurement tool may be developed based on the International Classification of Functioning Disability and Health (ICF) Core Sets for chronic conditions. The aim of the present study was to explore the possibility of constructing a cross-cultural measurement of functioning for patients with low back pain…

  1. Analysis of expediency to set regulators of high-pressure emergency core cooling system of WWER 1000 (B-320)

    International Nuclear Information System (INIS)

    Skalozubov, V.I.; Komarov, Yu.A.; Tikhonova, G.G.; Nikiforov, S.N.; Bogodist, V.V.; Fol'tov, I.M.; Khadzh Faradzhallakh Dabbakh, A.

    2011-01-01

    The work shows that setting regulative valves in high-pressure emergency core cooling system of WWER 1000/B-320 can be effective only involving the additional tuning to account traverse speed of operating elements of regulator and configuration of the systems providing cooling of primary loop.

  2. The ASN imposes on EDF complementary requirements for the setting of the hard-core unit

    International Nuclear Information System (INIS)

    Anon.

    2014-01-01

    In January 2014, the ASN (French Authority for Nuclear Safety) published a list of 19 decisions concerning the implementation of a 'post-Fukushima' hard-core unit in each EDF nuclear power plant. The purpose of the hard-core unit is to have structures and equipment able to resist very extreme events and able to assure the vital functions necessary for the reactor safety. The 19 decisions detail the rules for the design of the hard-core unit. For example the hard-core unit will have to resist earthquakes for which the probability of occurrence is about 1 every 20.000 years while the probability taking into account for the design of the reactor is only 1 every 1000 or 10.000 years

  3. YOUNG STARLESS CORES EMBEDDED IN THE MAGNETICALLY DOMINATED PIPE NEBULA. II. EXTENDED DATA SET

    Energy Technology Data Exchange (ETDEWEB)

    Frau, P.; Girart, J. M.; Padovani, M. [Institut de Ciencies de l' Espai (CSIC-IEEC), Campus UAB, Facultat de Ciencies, Torre C-5p, E-08193 Bellaterra, Catalunya (Spain); Beltran, M. T.; Sanchez-Monge, A. [INAF-Osservatorio Astrofisico di Arcetri, Largo Enrico Fermi 5, I-50125 Firenze (Italy); Busquet, G. [INAF-Istituto di Astrofisica e Planetologia Spaziali, via Fosso del Cavaliere 100, I-00133 Roma (Italy); Morata, O. [Institute of Astronomy and Astrophysics, Academia Sinica, P.O. Box 23-141, Taipei 10617, Taiwan (China); Masque, J. M.; Estalella, R. [Departament d' Astronomia i Meteorologia and Institut de Ciencies del Cosmos (IEEC-UB), Universitat de Barcelona, Marti i Franques 1, E-08028 Barcelona, Catalunya (Spain); Alves, F. O. [Argelander-Institut fuer Astronomie der Universitaet Bonn, Auf dem Huegel 71, D-53121 Bonn (Germany); Franco, G. A. P. [Departamento de Fisica-ICEx-UFMG, Caixa Postal 702, 30.123-970, Belo Horizonte (Brazil)

    2012-11-01

    The Pipe nebula is a massive, nearby, filamentary dark molecular cloud with a low star formation efficiency threaded by a uniform magnetic field perpendicular to its main axis. It harbors more than a hundred, mostly quiescent, very chemically young starless cores. The cloud is therefore a good laboratory to study the earliest stages of the star formation process. We aim to investigate the primordial conditions and the relation among physical, chemical, and magnetic properties in the evolution of low-mass starless cores. We used the IRAM 30 m telescope to map the 1.2 mm dust continuum emission of five new starless cores, which are in good agreement with previous visual extinction maps. For the sample of nine cores, which includes the four cores studied in a previous work, we derived an A {sub V} to N{sub H{sub 2}} factor of (1.27 {+-} 0.12) Multiplication-Sign 10{sup -21} mag cm{sup 2} and a background visual extinction of {approx}6.7 mag possibly arising from the cloud material. We derived an average core diameter of {approx}0.08 pc, density of {approx}10{sup 5} cm{sup -3}, and mass of {approx}1.7 M {sub Sun }. Several trends seem to exist related to increasing core density: (1) the diameter seems to shrink, (2) the mass seems to increase, and (3) the chemistry tends to be richer. No correlation is found between the direction of the surrounding diffuse medium magnetic field and the projected orientation of the cores, suggesting that large-scale magnetic fields seem to play a secondary role in shaping the cores. We also used the IRAM 30 m telescope to extend the previous molecular survey at 1 and 3 mm of early- and late-time molecules toward the same five new Pipe nebula starless cores, and analyzed the normalized intensities of the detected molecular transitions. We confirmed the chemical differentiation toward the sample and increased the number of molecular transitions of the 'diffuse' (e.g., the 'ubiquitous' CO, C{sub 2}H, and CS), &apos

  4. Protein folding: Defining a standard set of experimental conditions and a preliminary kinetic data set of two-state proteins

    DEFF Research Database (Denmark)

    Maxwell, Karen L.; Wildes, D.; Zarrine-Afsar, A.

    2005-01-01

    Recent years have seen the publication of both empirical and theoretical relationships predicting the rates with which proteins fold. Our ability to test and refine these relationships has been limited, however, by a variety of difficulties associated with the comparison of folding and unfolding ...... efforts is to set uniform standards for the experimental community and to initiate an accumulating, self-consistent data set that will aid ongoing efforts to understand the folding process....... constructs. The lack of a single approach to data analysis and error estimation, or even of a common set of units and reporting standards, further hinders comparative studies of folding. In an effort to overcome these problems, we define here a consensus set of experimental conditions (25°C at pH 7.0, 50 m...... rates, thermodynamics, and structure across diverse sets of proteins. These difficulties include the wide, potentially confounding range of experimental conditions and methods employed to date and the difficulty of obtaining correct and complete sequence and structural details for the characterized...

  5. Preliminary analysis on in-core fuel management optimization of molten salt pebble-bed reactor

    International Nuclear Information System (INIS)

    Xia Bing; Jing Xingqing; Xu Xiaolin; Lv Yingzhong

    2013-01-01

    The Nuclear Hot Spring (NHS) is a molten salt pebble-bed reactor featured by full power natural circulation. The unique horizontal coolant flow of the NHS demands the fuel recycling schemes based on radial zoning refueling and the corresponding method of fuel management optimization. The local searching algorithm (LSA) and the simulated annealing algorithm (SAA), the stochastic optimization methods widely used in the refueling optimization problems in LWRs, were applied to the analysis of refueling optimization of the NHS. The analysis results indicate that, compared with the LSA, the SAA can survive the traps of local optimized solutions and reach the global optimized solution, and the quality of optimization of the SAA is independent of the choice of the initial solution. The optimization result gives excellent effects on the in-core power flattening and the suppression of fuel center temperature. For the one-dimensional zoning refueling schemes of the NHS, the SAA is an appropriate optimization method. (authors)

  6. Developing a set of consensus indicators to support maternity service quality improvement: using Core Outcome Set methodology including a Delphi process.

    Science.gov (United States)

    Bunch, K J; Allin, B; Jolly, M; Hardie, T; Knight, M

    2018-05-16

    To develop a core metric set to monitor the quality of maternity care. Delphi process followed by a face-to-face consensus meeting. English maternity units. Three representative expert panels: service designers, providers and users. Maternity care metrics judged important by participants. Participants were asked to complete a two-phase Delphi process, scoring metrics from existing local maternity dashboards. A consensus meeting discussed the results and re-scored the metrics. In all, 125 distinct metrics across six domains were identified from existing dashboards. Following the consensus meeting, 14 metrics met the inclusion criteria for the final core set: smoking rate at booking; rate of birth without intervention; caesarean section delivery rate in Robson group 1 women; caesarean section delivery rate in Robson group 2 women; caesarean section delivery rate in Robson group 5 women; third- and fourth-degree tear rate among women delivering vaginally; rate of postpartum haemorrhage of ≥1500 ml; rate of successful vaginal birth after a single previous caesarean section; smoking rate at delivery; proportion of babies born at term with an Apgar score improvement. Achieving consensus on core metrics for monitoring the quality of maternity care. © 2018 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd on behalf of Royal College of Obstetricians and Gynaecologists.

  7. Recommendations for a first Core Outcome Measurement set for complex regional PAin syndrome Clinical sTudies (COMPACT)

    Science.gov (United States)

    Grieve, Sharon; Perez, Roberto SGM; Birklein, Frank; Brunner, Florian; Bruehl, Stephen; Harden R, Norman; Packham, Tara; Gobeil, Francois; Haigh, Richard; Holly, Janet; Terkelsen, Astrid; Davies, Lindsay; Lewis, Jennifer; Thomassen, Ilona; Connett, Robyn; Worth, Tina; Vatine, Jean-Jacques; McCabe, Candida S

    2017-01-01

    Complex Regional Pain Syndrome (CRPS) is a persistent pain condition that remains incompletely understood and challenging to treat. Historically, a wide range of different outcome measures have been used to capture the multidimensional nature of CRPS. This has been a significant limiting factor in the advancement of our understanding of the mechanisms and management of CRPS. In 2013, an international consortium of patients, clinicians, researchers and industry representatives was established, to develop and agree on a minimum core set of standardised outcome measures for use in future CRPS clinical research, including but not limited to clinical trials within adult populations The development of a core measurement set was informed through workshops and supplementary work, using an iterative consensus process. ‘What is the clinical presentation and course of CRPS, and what factors influence it?’ was agreed as the most pertinent research question that our standardised set of patient-reported outcome measures should be selected to answer. The domains encompassing the key concepts necessary to answer the research question were agreed as: pain, disease severity, participation and physical function, emotional and psychological function, self efficacy, catastrophizing and patient's global impression of change. The final core measurement set included the optimum generic or condition-specific patient-reported questionnaire outcome measures, which captured the essence of each domain, and one clinician reported outcome measure to capture the degree of severity of CRPS. The next step is to test the feasibility and acceptability of collecting outcome measure data using the core measurement set in the CRPS population internationally. PMID:28178071

  8. A Common Set of Core Values - The Foundation for a More Effective Joint Force

    Science.gov (United States)

    2015-05-18

    dismiss, but we must not forget the advice of Socrates . When discussing values, Socrates highlighted their importance, “This is not a trivial...question; what we are talking about is how one ought to live.”40 This is not to say that the methods of each service need to be the same but the core

  9. Preliminary fracture analysis of the core pressure boundary tube for the Advanced Neutron Source Research Reactor

    International Nuclear Information System (INIS)

    Schulz, K.C.

    1995-08-01

    The outer core pressure boundary tube (CPBT) of the Advanced neutron Source (ANS) reactor being designed at Oak Ridge National Laboratory is currently specified as being composed of 6061-T6 aluminum. ASME Boiler and Pressure Vessel Code fracture analysis rules for nuclear components are based on the use of ferritic steels; the expressions, tables, charts and equations were all developed from tests and analyses conducted for ferritic steels. Because of the nature of the Code, design with thin aluminum requires analytical approaches that do not directly follow the Code. The intent of this report is to present a methodology comparable to the ASME Code for ensuring the prevention of nonductile fracture of the CPBT in the ANS reactor. 6061-T6 aluminum is known to be a relatively brittle material; the linear elastic fracture mechanics (LEFM) approach is utilized to determine allowable flaw sizes for the CPBT. A J-analysis following the procedure developed by the Electric Power Research Institute was conducted as a check; the results matched those for the LEFM analysis for the cases analyzed. Since 6061-T6 is known to embrittle when irradiated, the reduction in K Q due to irradiation is considered in the analysis. In anticipation of probable requirements regarding maximum allowable flaw size, a survey of nondestructive inspection capabilities is also presented. A discussion of probabilistic fracture mechanics approaches, principally Monte Carlo techniques, is included in this report as an introduction to what quantifying the probability of nonductile failure of the CPBT may entail

  10. Hydrogel core flexible matrix composite (H-FMC) actuators: theory and preliminary modelling

    International Nuclear Information System (INIS)

    Dicker, M P M; Weaver, P M; Bond, I P; Rossiter, J M

    2014-01-01

    The underlying theory of a new actuator concept based on hydrogel core flexible matrix composites (H-FMC) is presented. The key principle that underlines the H-FMC actuator operation is that the three-dimensional swelling of a hydrogel is partially constrained in order to improve the amount of useful work done. The partial constraint is applied to the hydrogel by a flexible matrix composite (FMC) that minimizes the hydrogel's volume expansion while swelling. This constraint serves to maximize the fixed charge density and resulting osmotic pressure, the driving force behind actuation. In addition, for certain FMC fibre orientations the Poisson's ratio of the anisotropic FMC laminate converts previously unused hydrogel swelling in the radial and circumferential directions into useful axial strains. The potential benefit of the H-FMC concept to hydrogel actuator performance is shown through comparison of force–stroke curves and evaluation of improvements in useful actuation work. The model used to achieve this couples chemical and electrical components, represented with the Nernst–Plank and Poisson equations, as well as a linear elastic mechanical material model, encompassing limited geometric nonlinearities. It is found that improvements in useful actuation work in the order of 1500% over bare hydrogel performance are achieved by the H-FMC concept. A parametric study is also undertaken to determine the effect of various FMC design parameters on actuator free strain and blocking stress. A comparison to other actuator concepts is also included. (paper)

  11. Geochemical analysis of ice cores from Antarctic crossing-preliminary results

    International Nuclear Information System (INIS)

    Hammes, Daiane; Simoes, Jefferson; Ceron, Masiel; Santos, Maria; Vieria, Rosemary

    2009-01-01

    Two ice cores, IC-5 (82 Celsius degrade 30.5'S, 79 Celsius degrade 28'W, 950 m a.s.l.; 42.5 m) and one IC-6 (81 Celsius degrade 03'S, 79 Celsius degrade 51'W, 750 m a.s.l; 36 m) were collected as part of the 2004/2005 Chilean (with Brazilian collaboration) ITASE traverse from Patriot Hills to the South Pole. Mean accumulation rates in water equivalent calculated for the upper 10 m at the IC5 site is 0.37 m a-1 and 0.33 m a-1 at the site IC6. Coregistered samples (1595 for IC5 and 1368 for IC6) were obtained using a discrete continuous melter system with a pure nickel melt head at the Climate Change Institute under class 100 clean room conditions. All samples were analysed by ion chromatography (IC), inductively coupled plasma field mass spectrometry (ICP-MS), and stable isotope ratio mass spectrometry (IRMS).

  12. Toward the Development of a Core Set of Outcome Domains to Assess Shared Decision-making Interventions in Rheumatology

    DEFF Research Database (Denmark)

    Toupin-April, Karine; Barton, Jennifer; Fraenkel, Liana

    2017-01-01

    OBJECTIVE: The aim of this Outcome Measures in Rheumatology (OMERACT) Working Group was to determine the core set of outcome domains and subdomains for measuring the effectiveness of shared decision-making (SDM) interventions in rheumatology clinical trials. METHODS: Following the OMERACT Filter 2.......0, and based on a previous literature review of SDM outcome domains and a nominal group process at OMERACT 2014, (1) an online Delphi survey was conducted to gather feedback on the draft core set and refine its domains and subdomains, and (2) a workshop was held at the OMERACT 2016 meeting to gain consensus...... ranged from 83% to 100% of respondents). At OMERACT 2016, only 8% of the 96 attendees were patients/caregivers. Despite initial votes of support in breakout groups, there was insufficient comfort about the conceptualization of these 7 domains and 17 subdomains for these to be endorsed at OMERACT 2016...

  13. Protection set-points lines for the reactor core and considerations about power distribution and peak factors

    International Nuclear Information System (INIS)

    Furieri, E.B.

    1981-01-01

    In order to assure the reactor core integrity during the slow operational transients (power excursion above the nominal value and the high coolant temperature), the formation of a steam film (DNB-Departure from Nucleate Boiling) in the control rods must be avoided. The protection set points lines presents the points where DNBR (relation between critical heat flux-q sub(DNB) and the local heat flux-q' sub(local) is equal to 1.30, corrected by peak factors and uncertainty in function of ΔTr and T sub(R), respectively coolant elevation and medium coolant temperature in reactor pressure vessel. The curve set-points were determined using a new version of COBRA-IIIF (CUPRO) computer code, implemented with new subroutines and linearized convergence scheme. Pratical results for Angra-1 core were obtained and its were compared with the results from the fabricator. (E.G.) [pt

  14. International Classification of Functioning, Disability and Health Core Sets for cerebral palsy, autism spectrum disorder, and attention-deficit-hyperactivity disorder.

    Science.gov (United States)

    Schiariti, Verónica; Mahdi, Soheil; Bölte, Sven

    2018-05-30

    Capturing functional information is crucial in childhood disability. The International Classification of Functioning, Disability and Health (ICF) Core Sets promote assessments of functional abilities and disabilities in clinical practice regarding circumscribed diagnoses. However, the specificity of ICF Core Sets for childhood-onset disabilities has been doubted. This study aimed to identify content commonalities and differences among the ICF Core Sets for cerebral palsy (CP), and the newly developed Core Sets for autism spectrum disorder (ASD) and attention-deficit-hyperactivity disorder (ADHD). The categories within each Core Set were aggregated at the ICF component and chapter levels. Content comparison was conducted using descriptive analyses. The activities and participation component of the ICF was the most covered across all Core Sets. Main differences included representation of ICF components and coverage of ICF chapters within each component. CP included all ICF components, while ADHD and ASD predominantly focused on activities and participation. Environmental factors were highly represented in the ADHD Core Sets (40.5%) compared to the ASD (28%) and CP (27%) Core Sets. International Classification of Functioning, Disability and Health Core Sets for CP, ASD, and ADHD capture both common but also unique functional information, showing the importance of creating condition-specific, ICF-based tools to build functional profiles of individuals with childhood-onset disabilities. The International Classification of Functioning, Disability and Health (ICF) Core Sets for cerebral palsy (CP), autism spectrum disorder (ASD), and attention-deficit-hyperactivity disorder (ADHD) include unique functional information. The ICF-based tools for CP, ASD, and ADHD differ in terms of representation and coverage of ICF components and ICF chapters. Representation of environmental factors uniquely influences functioning and disability across ICF Core Sets for CP, ASD and ADHD.

  15. Nutritional implications of organic conversion in large scale food service preliminary results from Core Organic research

    DEFF Research Database (Denmark)

    Mikkelsen, Bent Egberg; He, Chen

    food coordinators in public schools in Denmark, Finland, Germany, and Italy. A questionnaire was adapted to fit the different languages and food cultures in the countries.. The data suggest that schools with organic supply tend to develop organisational environments that a more supportive for healthy......The discussion about nutritional advantages of organic consumption has traditionally focused on the properties of the food it self. Studies have shown however that change of consumption patterns towards organic food seems to induce changed dietary patterns. The current research was a part of the i......POPY study and was conducted to investigate if such changes can be found in school food settings. In other words does organic food schemes at school and related curricular activities help to create environments that are supportive for healthier eating among children? The research was carried out among school...

  16. Development of a core outcome set for orthodontic trials using a mixed-methods approach: protocol for a multicentre study.

    Science.gov (United States)

    Tsichlaki, Aliki; O'Brien, Kevin; Johal, Ama; Marshman, Zoe; Benson, Philip; Colonio Salazar, Fiorella B; Fleming, Padhraig S

    2017-08-04

    Orthodontic treatment is commonly undertaken in young people, with over 40% of children in the UK needing treatment and currently one third having treatment, at a cost to the National Health Service in England and Wales of £273 million each year. Most current research about orthodontic care does not consider what patients truly feel about, or want, from treatment, and a diverse range of outcomes is being used with little consistency between studies. This study aims to address these problems, using established methodology to develop a core outcome set for use in future clinical trials of orthodontic interventions in children and young people. This is a mixed-methods study incorporating four distinct stages. The first stage will include a scoping review of the scientific literature to identify primary and secondary outcome measures that have been used in previous orthodontic clinical trials. The second stage will involve qualitative interviews and focus groups with orthodontic patients aged 10 to 16 years to determine what outcomes are important to them. The outcomes elicited from these two stages will inform the third stage of the study in which a long-list of outcomes will be ranked in terms of importance using electronic Delphi surveys involving clinicians and patients. The final stage of the study will involve face-to-face consensus meetings with all stakeholders to discuss and agree on the outcome measures that should be included in the final core outcome set. This research will help to inform patients, parents, clinicians and commissioners about outcomes that are important to young people undergoing orthodontic treatment. Adoption of the core outcome set in future clinical trials of orthodontic treatment will make it easier for results to be compared, contrasted and combined. This should translate into improved decision-making by all stakeholders involved. The project has been registered on the Core Outcome Measures in Effectiveness Trials ( COMET ) website

  17. Defining a core outcome set for adolescent and young adult patients with a spinal deformity

    DEFF Research Database (Denmark)

    de Kleuver, Marinus; Faraj, Sayf S A; Holewijn, Roderick M

    2017-01-01

    2016, 7 representatives (panelists) of the national spinal surgery registries from each of the NSDS countries participated in a modified Delphi study. With a systematic literature review as a basis and the International Classification of Functioning, Disability and Health framework as guidance, 4...... consensus rounds were held. Consensus was defined as agreement between at least 5 of the 7 representatives. Data were analyzed qualitatively and quantitatively. Results - Consensus was reached on the inclusion of 13 core outcome domains: "satisfaction with overall outcome of surgery", "satisfaction...

  18. ISP: an optimal out-of-core image-set processing streaming architecture for parallel heterogeneous systems.

    Science.gov (United States)

    Ha, Linh Khanh; Krüger, Jens; Dihl Comba, João Luiz; Silva, Cláudio T; Joshi, Sarang

    2012-06-01

    Image population analysis is the class of statistical methods that plays a central role in understanding the development, evolution, and disease of a population. However, these techniques often require excessive computational power and memory that are compounded with a large number of volumetric inputs. Restricted access to supercomputing power limits its influence in general research and practical applications. In this paper we introduce ISP, an Image-Set Processing streaming framework that harnesses the processing power of commodity heterogeneous CPU/GPU systems and attempts to solve this computational problem. In ISP, we introduce specially designed streaming algorithms and data structures that provide an optimal solution for out-of-core multiimage processing problems both in terms of memory usage and computational efficiency. ISP makes use of the asynchronous execution mechanism supported by parallel heterogeneous systems to efficiently hide the inherent latency of the processing pipeline of out-of-core approaches. Consequently, with computationally intensive problems, the ISP out-of-core solution can achieve the same performance as the in-core solution. We demonstrate the efficiency of the ISP framework on synthetic and real datasets.

  19. A core outcomes set for clinical trials of interventions for young adults with type 1 diabetes

    DEFF Research Database (Denmark)

    Byrne, Molly; O'Connell, Anthony; Egan, Aoife M

    2017-01-01

    two online surveys to a sample of international key stakeholders. Participants in the first survey (survey 1; n = 132) and the second survey (survey 2; n = 81) rated the importance of the outcomes. Survey 2 participants received information on total mean rating for each outcome and a reminder...... that 70% of consensus group participants voted for their inclusion. RESULTS: Eight core outcomes were agreed for inclusion in the final COS: measures of diabetes-related stress; diabetes-related quality of life; number of severe hypoglycaemic events; self-management behaviour; number of instances...... of this COS will improve the quality of future research and increase opportunities for evidence synthesis. Future research is necessary to identify the most robust outcome measure instruments....

  20. Core information sets for informed consent to surgical interventions: baseline information of importance to patients and clinicians.

    Science.gov (United States)

    Main, Barry G; McNair, Angus G K; Huxtable, Richard; Donovan, Jenny L; Thomas, Steven J; Kinnersley, Paul; Blazeby, Jane M

    2017-04-26

    Consent remains a crucial, yet challenging, cornerstone of clinical practice. The ethical, legal and professional understandings of this construct have evolved away from a doctor-centred act to a patient-centred process that encompasses the patient's values, beliefs and goals. This alignment of consent with the philosophy of shared decision-making was affirmed in a recent high-profile Supreme Court ruling in England. The communication of information is central to this model of health care delivery but it can be difficult for doctors to gauge the information needs of the individual patient. The aim of this paper is to describe 'core information sets' which are defined as a minimum set of consensus-derived information about a given procedure to be discussed with all patients. Importantly, they are intended to catalyse discussion of subjective importance to individuals. The model described in this paper applies health services research and Delphi consensus-building methods to an idea orginally proposed 30 years ago. The hypothesis is that, first, large amounts of potentially-important information are distilled down to discrete information domains. These are then, secondly, rated by key stakeholders in multiple iterations, so that core information of agreed importance can be defined. We argue that this scientific approach is key to identifying information important to all stakeholders, which may otherwise be communicated poorly or omitted from discussions entirely. Our methods apply systematic review, qualitative, survey and consensus-building techniques to define this 'core information'. We propose that such information addresses the 'reasonable patient' standard for information disclosure but, more importantly, can serve as a spring board for high-value discussion of importance to the individual patient. The application of established research methods can define information of core importance to informed consent. Further work will establish how best to incorporate

  1. Development of a core set of SSR markers for the characterization of Gossypium germplasm

    Science.gov (United States)

    Molecular markers such as simple sequence repeats (SSR) are a useful tool for characterizing genetic diversity of Gossypium germplasm collections. Genetic profiles by DNA fingerprinting of cotton accessions can only be compared among different collections if a common set of molecular markers are us...

  2. Shrinking core? Exploring the differential agenda setting power of traditional and personalized news media

    NARCIS (Netherlands)

    Moeller, J.; Trilling, D.; Helberger, N.; Irion, K.; De Vreese, C.

    2016-01-01

    Purpose This paper aims to shed light on the impact of personalized news media on the shared issue agenda that provides democracies with a set of topics that structure the public debate. The advent of personalized news media that use smart algorithms to tailor the news offer to the user challenges

  3. An oceanic core complex (OCC) in the Albanian Dinarides? Preliminary paleomagnetic and structural results from the Mirdita Ophiolite (northern Albania)

    Science.gov (United States)

    Maffione, M.; Morris, A.; Anderson, M.

    2010-12-01

    Oceanic core complexes (OCCs) are dome-shaped massifs commonly associated with the inside corners of the intersection of transform faults and slow (and ultra-slow) spreading centres. They represent the uplifted footwalls of large-slip oceanic detachment faults (e.g. Cann et al., 1997; Blackman et al., 1998) and are composed of mantle and lower crustal rocks exhumed during fault displacement (Smith et al., 2006, 2008). Recent paleomagnetic studies of core samples from OCCs in the Atlantic Ocean (Morris et al., 2009; MacLeod et al., in prep) have confirmed that footwall sections undergo substantial rotation around (sub-) horizontal axes. These studies, therefore, support “rolling hinge” models for the evolution of OCCs, whereby oceanic detachment faults initiate at a steep angle at depth and then “roll-over” to their present day low angle orientations during unroofing (Buck, 1988; Wernicke & Axen, 1988; Lavier et al., 1999). However, a fully integrated paleomagnetic and structural analysis of this process is hampered by the one-dimensional sampling provided by ocean drilling of OCC footwalls. Therefore, ancient analogues for OCCs in ophiolites are of great interest, as these potentially provide 3-D exposures of these important structures and hence a more complete understanding of footwall strain and kinematics (providing that emplacement-related phases of deformation can be accounted for). Recently, the relationship between outcropping crustal and upper mantle rocks led Tremblay et al. (2009) to propose that an OCC is preserved within the Mirdita ophiolite of the Albanian Dinarides (northern Albania). This is a slice of Jurassic oceanic lithosphere exposed along a N-S corridor which escaped the main late Cenozoic Alpine deformation (Robertson, 2002, 2004; Dilek et al., 2007). Though in the eastern portion of the Mirdita ophiolite a Penrose-type sequence is present, in the western portion mantle rocks are in tectonic contact with upper crustal lithologies

  4. Correlation of parenting style and pediatric behavior guidance strategies in the dental setting: preliminary findings.

    Science.gov (United States)

    Aminabadi, Naser Asl; Farahani, Ramin Mostofi Zadeh

    2008-04-01

    The aim of this study was to investigate the influence of parenting style on the choice of proper behavior guidance strategies in pedodontics. Seventy-two children aged between 4 and 6 years (mean 5.12 years) with carious primary mandibular molars were selected. The Primary Caregivers' Practices Report (PCPR) was used to quantify authoritarian, permissive and authoritative aspects of the caregivers' parenting style. After inferior alveolar nerve block, carious lesions were removed and the teeth were restored using amalgam. The children's behavior during operation was assessed according to the sound, eye, and motor (SEM) scale. Communicative guidance, advance behavior guidance, parental separation, and deferred treatment were used for behavior management. The dominant authoritative score was observed in 50% of parents, permissive in 37.5%, and authoritarian in 12.5%. The mean SEM score in children belonging to authoritative parents was significantly lower than in children of permissive and of authoritarian parents (pparenting style. Advanced behavior guidance (protective stabilization) was applied in 16.7% of cases in the authoritative category and in 100% in the permissive and authoritarian categories. The use of restrictive devices (7.4%) and sedation (3.7%) was limited to the permissive category. Parental separation (40.7%) and deferred treatment (3.7%) were performed only in the permissive category. This study provides preliminary evidence that a child's reaction to restorative dental procedures is influenced by the nature of the caregiver's parenting style.

  5. A set of tetra-nucleotide core motif SSR markers for efficient identification of potato (Solanum tuberosum) cultivars.

    Science.gov (United States)

    Kishine, Masahiro; Tsutsumi, Katsuji; Kitta, Kazumi

    2017-12-01

    Simple sequence repeat (SSR) is a popular tool for individual fingerprinting. The long-core motif (e.g. tetra-, penta-, and hexa-nucleotide) simple sequence repeats (SSRs) are preferred because they make it easier to separate and distinguish neighbor alleles. In the present study, a new set of 8 tetra-nucleotide SSRs in potato ( Solanum tuberosum ) is reported. By using these 8 markers, 72 out of 76 cultivars obtained from Japan and the United States were clearly discriminated, while two pairs, both of which arose from natural variation, showed identical profiles. The combined probability of identity between two random cultivars for the set of 8 SSR markers was estimated to be 1.10 × 10 -8 , confirming the usefulness of the proposed SSR markers for fingerprinting analyses of potato.

  6. A preliminary study on the mechanism of fertilization and setting fruit of apple

    International Nuclear Information System (INIS)

    Zhou Xueming; Ma Huanpu; Wang Fengzhen; Li Wuxing; Shan Yongming

    1995-01-01

    The content of GA 3 , GA 4+7 , ABA, IAA, Z and ZR in the fruits and fruiting shoots treated with PP 333 , GA 3 was measured by GC and that of 15 N was measured by MS. The results showed that the number of fruits was increased, but the size of fruit and length of fruiting shoot were inhibited by PP 333 treatment. Opposite results were observed with GA 3 treatment although the number of fruits was higher than that in control. The content of CTK was consistent with the ability of setting fruit, but no relationship was found between the other hormones and setting fruit. Together with evidences of the high level of 15 N and total N or IAA + CTK/GA 4=7 in fruits and the low level of those in fruiting shoots after PP 333 treatment allow us to conclude that the mechanism of PP 333 on setting fruit probably is to inhibit biosynthesis of GAs, to increase the content of CTK, and to promote the ratio value of IAA + CTK/GA 4+7 , increasing and changing the status of nutrition. The distribution of 15 N is changed from the order of king fruit>fruiting shoot>lateral fruit to king fruit>lateral fruit>fruiting shoot. Thus the competition between fruits and shoots growth was weaken, which resulted in the higher ability of setting fruit than that in the control and GA 3 treatment

  7. Adapting Evidence-Based Mental Health Treatments in Community Settings: Preliminary Results from a Partnership Approach

    Science.gov (United States)

    Southam-Gerow, Michael A.; Hourigan, Shannon E.; Allin, Robert B., Jr.

    2009-01-01

    This article describes the application of a university-community partnership model to the problem of adapting evidence-based treatment approaches in a community mental health setting. Background on partnership research is presented, with consideration of methodological and practical issues related to this kind of research. Then, a rationale for…

  8. Set shifting deficits in melancholic vs. non-melancholic depression: preliminary findings.

    Science.gov (United States)

    Michopoulos, I; Zervas, I M; Papakosta, V M; Tsaltas, E; Papageorgiou, C; Manessi, T; Papakostas, Y G; Lykouras, L; Soldatos, C R

    2006-09-01

    Twenty-two patients with major depressive disorder, 11 of them with melancholic features, and 11 controls were investigated with CANTAB subtests focusing in visual memory/learning and executive functions. Melancholic patients performed worse than the other groups in all tasks and manifested a significant impairment in set shifting. The results are discussed in association with prefrontal dysfunction.

  9. Student Self-Determination: A Preliminary Investigation of the Role of Participation in Inclusive Settings

    Science.gov (United States)

    Hughes, Carolyn; Cosgriff, Joseph C.; Agran, Martin; Washington, Barbara H.

    2013-01-01

    Little is known about the effects of participation in inclusive settings on student self-determination. In this exploratory study, we examined the association between students' inclusive school and community activities and the self-determination skills of active involvement in IEP activities and use of selected self-determination strategies.…

  10. Genome-Wide Temporal Expression Profiling in Caenorhabditis elegans Identifies a Core Gene Set Related to Long-Term Memory.

    Science.gov (United States)

    Freytag, Virginie; Probst, Sabine; Hadziselimovic, Nils; Boglari, Csaba; Hauser, Yannick; Peter, Fabian; Gabor Fenyves, Bank; Milnik, Annette; Demougin, Philippe; Vukojevic, Vanja; de Quervain, Dominique J-F; Papassotiropoulos, Andreas; Stetak, Attila

    2017-07-12

    The identification of genes related to encoding, storage, and retrieval of memories is a major interest in neuroscience. In the current study, we analyzed the temporal gene expression changes in a neuronal mRNA pool during an olfactory long-term associative memory (LTAM) in Caenorhabditis elegans hermaphrodites. Here, we identified a core set of 712 (538 upregulated and 174 downregulated) genes that follows three distinct temporal peaks demonstrating multiple gene regulation waves in LTAM. Compared with the previously published positive LTAM gene set (Lakhina et al., 2015), 50% of the identified upregulated genes here overlap with the previous dataset, possibly representing stimulus-independent memory-related genes. On the other hand, the remaining genes were not previously identified in positive associative memory and may specifically regulate aversive LTAM. Our results suggest a multistep gene activation process during the formation and retrieval of long-term memory and define general memory-implicated genes as well as conditioning-type-dependent gene sets. SIGNIFICANCE STATEMENT The identification of genes regulating different steps of memory is of major interest in neuroscience. Identification of common memory genes across different learning paradigms and the temporal activation of the genes are poorly studied. Here, we investigated the temporal aspects of Caenorhabditis elegans gene expression changes using aversive olfactory associative long-term memory (LTAM) and identified three major gene activation waves. Like in previous studies, aversive LTAM is also CREB dependent, and CREB activity is necessary immediately after training. Finally, we define a list of memory paradigm-independent core gene sets as well as conditioning-dependent genes. Copyright © 2017 the authors 0270-6474/17/376661-12$15.00/0.

  11. Multiprofessional evaluation in clinical practice: establishing a core set of outcome measures for children with cerebral palsy.

    Science.gov (United States)

    Mäenpää, Helena; Autti-Rämö, Ilona; Varho, Tarja; Forsten, Wivi; Haataja, Leena

    2017-03-01

    To develop a national consensus on outcome measures that define functional ability in children with cerebral palsy (CP) according to the International Classification of Functioning, Disability and Health (ICF) framework. The project started in 2008 in neuropaediatric units of two university hospitals and one outpatient clinic. Each professional group selected representatives to be knowledge brokers for their own specialty. Based on the evidence, expert opinion, and the ICF framework, multiprofessional teams selected the most valid measures used in clinical practice (2009-2010). Data from 269 children with CP were analysed, classified by the Gross Motor Function Classification System, Manual Ability Classification System, and Communication Function Classification System, and evaluated. The process aimed at improving and unifying clinical practice in Finland through a national consensus on the core set of measures. The selected measures were presented by professional groups, and consensus was reached on the recommended core set of measures to be used in all hospitals treating children with CP in Finland. A national consensus on relevant and feasible measures is essential for identifying differences in the effectiveness of local practices, and for conducting multisite intervention studies. This project showed that multiprofessional rehabilitation practices can be improved through respect for and inclusion of everyone involved. © 2016 Mac Keith Press.

  12. Protocol for the development of a core domain set for hidradenitis suppurativa trial outcomes

    DEFF Research Database (Denmark)

    Thorlacius, Linnea; Ingram, John R; Garg, Amit

    2017-01-01

    . A recent systematic review found a total of 30 outcome measure instruments in 12 RCTs. This use of a broad range of outcome measures can increase difficulties in interpretation and comparison of results and may potentially obstruct appropriate evidence synthesis by causing reporting bias. One strategy...... of candidate items will be obtained by combining three data sets: (1) a systematic review of the literature, (2) US and Danish qualitative interview studies involving patients with HS and (3) an online healthcare professional (HCP) item generation survey. To reach consensus on the COS, 4 anonymous online...... Delphi rounds are then planned together with 2 face-to-face consensus meetings (1 in Europe and 1 in the USA) to ensure global representation. ETHICS AND DISSEMINATION: The study will be performed according to the Helsinki declaration. All results from the study, including inconclusive or negative...

  13. Comparing simple root phenotyping methods on a core set of rice genotypes.

    Science.gov (United States)

    Shrestha, R; Al-Shugeairy, Z; Al-Ogaidi, F; Munasinghe, M; Radermacher, M; Vandenhirtz, J; Price, A H

    2014-05-01

    Interest in belowground plant growth is increasing, especially in relation to arguments that shallow-rooted cultivars are efficient at exploiting soil phosphorus while deep-rooted ones will access water at depth. However, methods for assessing roots in large numbers of plants are diverse and direct comparisons of methods are rare. Three methods for measuring root growth traits were evaluated for utility in discriminating rice cultivars: soil-filled rhizotrons, hydroponics and soil-filled pots whose bottom was sealed with a non-woven fabric (a potential method for assessing root penetration ability). A set of 38 rice genotypes including the OryzaSNP set of 20 cultivars, additional parents of mapping populations and products of marker-assisted selection for root QTLs were assessed. A novel method of image analysis for assessing rooting angles from rhizotron photographs was employed. The non-woven fabric was the easiest yet least discriminatory method, while the rhizotron was highly discriminatory and allowed the most traits to be measured but required more than three times the labour of the other methods. The hydroponics was both easy and discriminatory, allowed temporal measurements, but is most likely to suffer from artefacts. Image analysis of rhizotrons compared favourably to manual methods for discriminating between cultivars. Previous observations that cultivars from the indica subpopulation have shallower rooting angles than aus or japonica cultivars were confirmed in the rhizotrons, and indica and temperate japonicas had lower maximum root lengths in rhizotrons and hydroponics. It is concluded that rhizotrons are the preferred method for root screening, particularly since root angles can be assessed. © 2013 German Botanical Society and The Royal Botanical Society of the Netherlands.

  14. A two-step approach for the preliminary evaluation of the thermal-hydraulics and safety of the ELSY open square core design

    International Nuclear Information System (INIS)

    Meloni, Paride; Bandini, Giacomino; Polidori, Massimiliano; Cervone, Antonio; Manservisi, Sandro

    2009-01-01

    Several innovative solutions for a liquid metal fast reactor design have been investigated in the EURATOM Sixth Framework Programme and an open-assembly core design for the ELSY (European Lead-cooled System) reactor has been proposed by ENEA. The development of this new reactor, based on innovative neutronic and safety considerations, requires a new approach to the thermal-hydraulic (T/H) core design. In this paper a new two-step approach of the T/H analysis for this open-assembly core is presented and, in particular is used for the evaluation of the preliminary core design of a 1500 MW lead fast reactor with open square lattice and three fuel radial zones with different levels of enrichment. In the first step a preliminary thermal-hydraulic and safety evaluation of the core neutronic design is investigated by using a one-dimensional RELAP5 model for independent channel analysis. Then two and three-dimensional effects are taken into account by using a dedicated tool for the evaluation of assembly mixing effects. The RELAP5 model, based on pressure loss and heat transfer correlations available for heavy liquid metal flows in rod bundle, consists of completely independent assemblies and therefore it can be used for a conservative evaluation of the thermal-hydraulics of the core reactor. Due to the open-lattice configuration, the two and three-dimensional effects are important and they are taken into account by using a simplified three-dimensional numerical model of an open square lattice reactor core, developed with the purpose of analyzing the whole core behavior. The numerical simulation is performed at assembly length level taking into account the local fluctuations of turbulent viscosity and energy exchange coefficients at sub-channel level through transfer operators based on parametric coefficients. A preliminary evaluation of the mixing effects between assembly flows on the temperature field has been performed by using an average assembly turbulent viscosity

  15. Preliminary Study on Prevalence and Associated Factors with Sarcopenia in a Geriatric Hospitalized Rehabilitation Setting.

    Science.gov (United States)

    Pongpipatpaiboon, K; Kondo, I; Onogi, K; Mori, S; Ozaki, K; Osawa, A; Matsuo, H; Itoh, N; Tanimoto, M

    2018-01-01

    The reported prevalence of sarcopenia has shown a wide range, crucially based on the diagnostic criteria and setting. This cross-sectional study evaluated the prevalence of sarcopenia and sought to identify factors associated with sarcopenia on admission in a specialized geriatric rehabilitation setting based on the newly developed the Asian Working Group for Sarcopenia algorithm. Among 87 participants (mean age, 76.05 ± 7.57 years), 35 (40.2%) were classified as showing sarcopenia on admission. Prevalence was high, particularly among participants ≥80 years old, with tendencies toward lower body mass index, smoking habit, lower cognitive function, and greater functional impairment compared with the non-sarcopenic group. Identification of sarcopenia in elderly patients before rehabilitation and consideration of risk factors may prove helpful in achieving rehabilitation outcomes.

  16. Optimization method development of the core characteristics of a fast reactor in order to explore possible high performance solutions (a solution being a consistent set of fuel, core, system and safety)

    International Nuclear Information System (INIS)

    Ingremeau, J.-J.X.

    2011-01-01

    this innovative feature leads to much higher performing and/or safer cores. The FARM approach has also been applied to a GFR concept using a vanadium cladding. However the large uncertainties involved do not really enable one to evaluate the performance of this promising concept.In summary, the feasibility of a global multi-disciplinary optimization has been demonstrated. Although the resulting method (FARM) is less accurate than the conventional method, it allows fast optimization and permits a large number of cores to be explored quickly, and is ideally suited for the preliminary designs studies before further refinement of the core design. (author) [fr

  17. The Gestalt of functioning in autism spectrum disorder: Results of the international conference to develop final consensus International Classification of Functioning, Disability and Health core sets.

    Science.gov (United States)

    Bölte, Sven; Mahdi, Soheil; de Vries, Petrus J; Granlund, Mats; Robison, John E; Shulman, Cory; Swedo, Susan; Tonge, Bruce; Wong, Virginia; Zwaigenbaum, Lonnie; Segerer, Wolfgang; Selb, Melissa

    2018-01-01

    Autism spectrum disorder is associated with diverse social, educational, and occupational challenges. To date, no standardized, internationally accepted tools exist to assess autism spectrum disorder-related functioning. World Health Organization's International Classification of Functioning, Disability and Health can serve as foundation for developing such tools. This study aimed to identify a comprehensive, a common brief, and three age-appropriate brief autism spectrum disorder Core Sets. Four international preparatory studies yielded in total 164 second-level International Classification of Functioning, Disability and Health candidate categories. Based on this evidence, 20 international autism spectrum disorder experts applied an established iterative decision-making consensus process to select from the candidate categories the most relevant ones to constitute the autism spectrum disorder Core Sets. The consensus process generated 111 second-level International Classification of Functioning, Disability and Health categories in the Comprehensive Core Set for autism spectrum disorder-one body structure, 20 body functions, 59 activities and participation categories, and 31 environmental factors. The Common Brief Core Set comprised 60 categories, while the age-appropriate core sets included 73 categories in the preschool version (0- to 5-year-old children), 81 in the school-age version (6- to 16-year-old children and adolescents), and 79 in the older adolescent and adult version (⩾17-year-old individuals). The autism spectrum disorder Core Sets mark a milestone toward the standardized assessment of autism spectrum disorder-related functioning in educational, administrative, clinical, and research settings.

  18. A experiência brasileira com o core set da classificação internacional de funcionalidade, incapacidade e saúde para lombalgia La experiencia brasileña con el core set de la clasificación internacional de funcionalidad, incapacidad y salud para dorsalgia The Brazilian experience with the international classification of functioning, disability and health core set for low back pain

    Directory of Open Access Journals (Sweden)

    Marcelo Riberto

    2011-01-01

    Full Text Available OBJETIVO: Validar empiricamente o core set da CIF para lombalgia e descrever a funcionalidade de uma amostra de pacientes com lombalgia mecânica crônica inespecífica. MÉTODOS: Vinte e nove pacientes de um centro de reabilitação foram avaliados por meio do core set da CIF para lombalgia e pelo questionário de Roland Morris (QRM e SF-36. RESULTADOS: Todas as categorias de estruturas do corpo do core set se mostraram comprometidas em ao menos 80% dos pacientes, sendo consideradas validadas. Entre as 19 categorias de Funções do corpo, apenas quatro estavam comprometidas em menos que 80% dos pacientes, sendo consideradas não-validadas, o mesmo foi observado para cinco das 29 de Atividades e participações e cinco das 25 categorias de Fatores ambientais. CONCLUSÕES: As categorias selecionadas para o core set da CIF para lombalgia foram consideradas empiricamente validadas e em conjunto permitiram descrever a multiplicidade de repercussões dessa condição de saúde sobre a funcionalidade das pessoas. O core set da CIF serve para guiar a intervenção terapêutica interdisciplinar.OBJETIVO: Validar empíricamente el core set de la CIF para dorsalgia y describir la funcionalidad de una muestra de pacientes con dorsalgia mecánica crónica inespecífica. MÉTODOS: Veintinueve pacientes de un centro de rehabilitación fueron evaluados por medio del core set de la CIF para dorsalgia, y mediante el cuestionario Roland Moris (QRM y SF-36. RESULTADOS: Todas las categorías de Estructuras del cuerpo del core set se mostraron comprometidas en por lo menos 80% de los pacientes, siendo consideradas validadas. Entre las 19 categorías de Funciones del cuerpo, sólo cuatro estaban comprometidas en menos de 80% de los pacientes, siendo consideradas como no validadas; lo mismo fue observado para 5 de las 29 categorías de Actividades y participaciones, y 5 de las 25 categorías de Factores ambientales. CONCLUSIONES: Las categorías seleccionadas para el

  19. A preliminary study on the behavior of trace elements in sediment cores from Ilha Grande (Rio de Janeiro State) by neutron activation analysis

    Energy Technology Data Exchange (ETDEWEB)

    Wasserman, Julio Cesar [Universidade Federal Fluminense, Niteroi, RJ (Brazil). Dept. de Geoquimica; Figueiredo, Ana Maria G. [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil); Figueira, Andre Luiz [Universidade do Estado, Rio de Janeiro, RJ (Brazil). Dept. de Oceanografia; Kelecom, Alphonse [Universidade Federal Fluminense, Niteroi, RJ (Brazil). Dept. de Biologia Geral

    2002-07-01

    The present work aims to identify atmospheric and marine inputs of 9 metals (Ba, Co, Cr, Cs, Fe, Hf, Rb, Sc, Zn), 8 rare earths (La, Ce, Nd, Sm, Eu, Tb, Yb e Lu), 2 actinides (U, Th) and 3 non-metals (As, Sb, Se) in sediment cores from a remote area, the Biological Reserve of Praia do Sul, Ilha Grande, Rio de Janeiro, Brazil. The sediment cores were sampled in a peat bog (out of the tidal reach) and in a mangrove, downstream of the peat bog. The analytical technique employed was Instrumental Neutron Activation Analysis. The samples were irradiated for 16 hours at a thermal neutron flux of 10{sup 12} n cm{sup -2} s{sup -1} at the IEA-R1 reactor of IPEN. The measurements of the induced gamma-ray activity were carried out by high resolution gamma spectrometry, with an hyperpure Ge detector. A preliminary sediment dating with Po-210 was also carried out by applying radiochemical procedures and measurements were done in an Alfa spectrometer The results indicate that the peat bog core present a slight surface enrichment that can be attributed to atmospheric inputs. Increasing concentrations of metals with age is probably due to history of soil occupation. In the mangrove core, no significant increase in concentration could be detected in the surface sediments (except for Zn) confirming the suitability of the peat bog core as a tracer for atmospheric inputs. (author)

  20. A preliminary study on the behavior of trace elements in sediment cores from Ilha Grande (Rio de Janeiro State) by neutron activation analysis

    International Nuclear Information System (INIS)

    Wasserman, Julio Cesar; Figueira, Andre Luiz; Kelecom, Alphonse

    2002-01-01

    The present work aims to identify atmospheric and marine inputs of 9 metals (Ba, Co, Cr, Cs, Fe, Hf, Rb, Sc, Zn), 8 rare earths (La, Ce, Nd, Sm, Eu, Tb, Yb e Lu), 2 actinides (U, Th) and 3 non-metals (As, Sb, Se) in sediment cores from a remote area, the Biological Reserve of Praia do Sul, Ilha Grande, Rio de Janeiro, Brazil. The sediment cores were sampled in a peat bog (out of the tidal reach) and in a mangrove, downstream of the peat bog. The analytical technique employed was Instrumental Neutron Activation Analysis. The samples were irradiated for 16 hours at a thermal neutron flux of 10 12 n cm -2 s -1 at the IEA-R1 reactor of IPEN. The measurements of the induced gamma-ray activity were carried out by high resolution gamma spectrometry, with an hyperpure Ge detector. A preliminary sediment dating with Po-210 was also carried out by applying radiochemical procedures and measurements were done in an Alfa spectrometer The results indicate that the peat bog core present a slight surface enrichment that can be attributed to atmospheric inputs. Increasing concentrations of metals with age is probably due to history of soil occupation. In the mangrove core, no significant increase in concentration could be detected in the surface sediments (except for Zn) confirming the suitability of the peat bog core as a tracer for atmospheric inputs. (author)

  1. Economic evaluation of childhood epilepsy in a resource-challenged setting: A preliminary survey.

    Science.gov (United States)

    Ibrahim, Aliyu; Umar, Umar Isa; Usman, Umar Musa; Owolabi, Lukman Femi

    2017-11-01

    Considerable disease variability exists between patients with epilepsy, and the societal costs for epilepsy care are overall high, because of high frequency in the general population especially in children from developing countries. A cross-sectional study where children with established diagnosis of epilepsy were interviewed using a semi-structured questionnaire. Prevalence-based costs were stratified by patients' sociodemographic characteristics and socioeconomic scores (SES). The 'bottom-up' and 'human capital' approaches were used to generate estimates on the direct and indirect (productivity losses) costs of epilepsy, respectively. All estimates of the financial burden of epilepsy were analyzed from the 'societal perspective' using IBM SPSS statistics software, version 20.0. The study had 103 enrollees with most in the age group of 0-5years (45.6%). Majority (61.3%) belong to the low socioeconomic class (Ogunlesi SES class IV and V) and reside (80.6%) in an urban setting. The total direct and indirect costs per month were ₦2,149,965.00 ($8497.88) and ₦363,187.80 ($1435.52), respectively. The cost of care per patient per annum was ₦292,794.50 ($1157.29), and the total cost for all the patients per year was ₦30,157,833.60 ($119,200.92). Investigative procedures are the principal cost drivers (₦15,861.17 or $18.15) comprising approximately 58.7% of the total direct costs per patient. Cost of investigations contributed immensely to the total direct cost of care in our study. With the present economic situation in the country, out-of-pocket payments may contribute significantly to catastrophic expenditures and worsening of secondary treatment gap in children with epilepsy. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. Content validation of the international classification of functioning, disability and health core set for stroke from gender perspective using a qualitative approach.

    Science.gov (United States)

    Glässel, A; Coenen, M; Kollerits, B; Cieza, A

    2014-06-01

    The extended ICF Core Set for stroke is an application of the International Classification of Functioning, Disability and Health (ICF) of the World Health Organisation (WHO) with the purpose to represent the typical spectrum of functioning of persons with stroke. The objective of the study is to add evidence to the content validity of the extended ICF Core Set for stroke from persons after stroke taking into account gender perspective. A qualitative study design was conducted by using individual interviews with women and men after stroke in an in- and outpatient rehabilitation setting. The sampling followed the maximum variation strategy. Sample size was determined by saturation. Concepts from qualitative data analysis were linked to ICF categories and compared to the extended ICF Core Set for stroke. Twelve women and 12 men participated in 24 individual interviews. In total, 143 out of 166 ICF categories included in the extended ICF Core Set for stroke were confirmed (women: N.=13; men: N.=17; both genders: N.=113). Thirty-eight additional categories that are not yet included in the extended ICF Core Set for stroke were raised by women and men. This study confirms that the experience of functioning and disability after stroke shows communalities and differences for women and men. The validity of the extended ICF Core Set for stroke could be mostly confirmed, since it does not only include those areas of functioning and disability relevant to both genders but also those exclusively relevant to either women or men. Further research is needed on ICF categories not yet included in the extended ICF Core Set for stroke.

  3. Beyond diagnosis: the Core Sets for persons with schizophrenia based on the World Health Organization's International Classification of Functioning, Disability, and Health.

    Science.gov (United States)

    Gómez-Benito, Juana; Guilera, Georgina; Barrios, Maite; Rojo, Emilio; Pino, Oscar; Gorostiaga, Arantxa; Balluerka, Nekane; Hidalgo, María Dolores; Padilla, José Luis; Benítez, Isabel; Selb, Melissa

    2017-07-30

    Based on the International Classification of Functioning, Disability and Health (ICF), this paper presents the results of the process to develop the Comprehensive and Brief Core Sets for schizophrenia that allow to comprehensively describe functioning in persons with schizophrenia. Twenty health professionals from diverse backgrounds participated in a formal and iterative decision-making process during an international consensus conference to develop these Core Sets. The conference was carried out based on evidence gathered from four preparatory studies (systematic literature review, qualitative study, expert survey, and empirical study). The first step of this decision-making and consensus process comprised of discussions and voting in working groups and plenary sessions to develop the comprehensive version. The categories of the Comprehensive ICF Core Set for schizophrenia served as the basis for the second step -a ranking and cutoff procedure to decide on the brief version. Of the 184 candidate categories identified in the preparatory studies, 97 categories were included in the Comprehensive Core Set for schizophrenia. A total of 25 categories were selected to constitute the Brief Core Set. The formal decision-making and consensus process integrating evidence from four preparatory studies and expert opinion led to the first version of the Core Sets for schizophrenia. Comprehensive and Brief Core Sets for schizophrenia may provide a common language among different health professionals and researchers, and a basic international standard of what to measure, report, and assess the functioning of persons with schizophrenia. Implications for rehabilitation Schizophrenia is a chronic mental disorder that has a tremendous impact on functioning and daily life of persons living with the disorder. The International Classification of Functioning, Disability and Health (ICF) offers an internationally recognized standard for describing the functioning status of these

  4. [Can ICF core sets be helpful in preparing a social-medical expert report due to incapacity to work?--a first proposal].

    Science.gov (United States)

    Kirschneck, M; Legner, R; Armbrust, W; Nowak, D; Cieza, A

    2015-04-01

    Social-medical expert reports from the German statutory pension insurance are essential for the German statutory pension regulatory authority to decide whether to grant services regarding participation as well as retirement pensions due to incapacity to work.The objective of this investigation is to determine whether the ICF Core Sets and other international approaches, such as the EUMASS Core Sets or ICF Core Set for vocational rehabilitation cover the content of the social-medical expert reports as well as to propose an approach how the ICF can be economically used by the social medicine practitioner when writing a social-medical expert report. A retrospective quantitative study design was used to translate a total of 294 social-medical expert reports from patients with low back pain (LBP) or chronic widespread pain (CWP) into the language of the ICF (linking) by 2 independent health professionals and compare the results with the ICF Core Sets for specific health conditions and other international approaches. The content of social-medical expert reports was largely reflected by the condition specific brief ICF Core Sets, brief ICF Core Sets for vocational rehabilitation and EUMASS Core Sets. The weighted Kappa statistic for the agreement between the 2 health professionals who translated the expert reports were in CWP 0.69 with a bootstrapped confidence interval of 0.67-0.71 and in LBP 0.73 (0.71-0.74). The analyses show that the content of social-medical expert reports varies enormously. A combination of a condition specific brief ICF Core Set as well as vocational rehabilitation and EUMASS ICF Core Sets as well as all ICF-categories from the expert reports that were named at least in 50% of it can largely provide a basis for preparing expert reports. Within the scope of implementation the need for a specific ICF Core Set for expert reports of the German statutory pension insurance should be further analyzed and discussed. © Georg Thieme Verlag KG Stuttgart

  5. The Geriatric ICF Core Set reflecting health-related problems in community-living older adults aged 75 years and older without dementia: development and validation.

    Science.gov (United States)

    Spoorenberg, Sophie L W; Reijneveld, Sijmen A; Middel, Berrie; Uittenbroek, Ronald J; Kremer, Hubertus P H; Wynia, Klaske

    2015-01-01

    The aim of the present study was to develop a valid Geriatric ICF Core Set reflecting relevant health-related problems of community-living older adults without dementia. A Delphi study was performed in order to reach consensus (≥70% agreement) on second-level categories from the International Classification of Functioning, Disability and Health (ICF). The Delphi panel comprised 41 older adults, medical and non-medical experts. Content validity of the set was tested in a cross-sectional study including 267 older adults identified as frail or having complex care needs. Consensus was reached for 30 ICF categories in the Delphi study (fourteen Body functions, ten Activities and Participation and six Environmental Factors categories). Content validity of the set was high: the prevalence of all the problems was >10%, except for d530 Toileting. The most frequently reported problems were b710 Mobility of joint functions (70%), b152 Emotional functions (65%) and b455 Exercise tolerance functions (62%). No categories had missing values. The final Geriatric ICF Core Set is a comprehensive and valid set of 29 ICF categories, reflecting the most relevant health-related problems among community-living older adults without dementia. This Core Set may contribute to optimal care provision and support of the older population. Implications for Rehabilitation The Geriatric ICF Core Set may provide a practical tool for gaining an understanding of the relevant health-related problems of community-living older adults without dementia. The Geriatric ICF Core Set may be used in primary care practice as an assessment tool in order to tailor care and support to the needs of older adults. The Geriatric ICF Core Set may be suitable for use in multidisciplinary teams in integrated care settings, since it is based on a broad range of problems in functioning. Professionals should pay special attention to health problems related to mobility and emotional functioning since these are the most

  6. Transcriptional differences between normal and glioma-derived glial progenitor cells identify a core set of dysregulated genes.

    Science.gov (United States)

    Auvergne, Romane M; Sim, Fraser J; Wang, Su; Chandler-Militello, Devin; Burch, Jaclyn; Al Fanek, Yazan; Davis, Danielle; Benraiss, Abdellatif; Walter, Kevin; Achanta, Pragathi; Johnson, Mahlon; Quinones-Hinojosa, Alfredo; Natesan, Sridaran; Ford, Heide L; Goldman, Steven A

    2013-06-27

    Glial progenitor cells (GPCs) are a potential source of malignant gliomas. We used A2B5-based sorting to extract tumorigenic GPCs from human gliomas spanning World Health Organization grades II-IV. Messenger RNA profiling identified a cohort of genes that distinguished A2B5+ glioma tumor progenitor cells (TPCs) from A2B5+ GPCs isolated from normal white matter. A core set of genes and pathways was substantially dysregulated in A2B5+ TPCs, which included the transcription factor SIX1 and its principal cofactors, EYA1 and DACH2. Small hairpin RNAi silencing of SIX1 inhibited the expansion of glioma TPCs in vitro and in vivo, suggesting a critical and unrecognized role of the SIX1-EYA1-DACH2 system in glioma genesis or progression. By comparing the expression patterns of glioma TPCs with those of normal GPCs, we have identified a discrete set of pathways by which glial tumorigenesis may be better understood and more specifically targeted. Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.

  7. New Hybrid Multiple Attribute Decision-Making Model for Improving Competence Sets: Enhancing a Company’s Core Competitiveness

    Directory of Open Access Journals (Sweden)

    Kuan-Wei Huang

    2016-02-01

    Full Text Available A company’s core competitiveness depends on the strategic allocation of its human resources in alignment with employee capabilities. Competency models can identify the range of capabilities at a company’s disposal, and this information can be used to develop internal or external education training policies for sustainable development. Such models can ensure the importation of a strategic orientation reflecting the growth of its employee competence set and enhancing human resource sustainably. This approach ensures that the most appropriate people are assigned to the most appropriate positions. In this study, we proposed a new hybrid multiple attributed decision-making model by using the Decision-making trial and Evaluation Laboratory Technique (DEMATEL to construct an influential network relation map (INRM and determined the influential weights by using the basic concept of the analytic network process (called DEMATEL-based ANP, DANP; the influential weights were then adopted with a modified Vise Kriterijumska Optimizacija I Kompromisno Resenje (VIKOR method. A simple forecasting technique as an iteration function was also proposed. The proposed model was effective. We expect that the proposed model can facilitate making timely revisions, reflecting the growth of employee competence sets, reducing the performance gap toward the aspiration level, and ensuring the sustainability of a company.

  8. Characterization of chickpea germplasm conserved in the Indian National Genebank and development of a core set using qualitative and quantitative trait data

    Directory of Open Access Journals (Sweden)

    Sunil Archak

    2016-10-01

    Full Text Available Chickpea is the third most important pulse crop as a source of dietary protein. Ever-increasing demand in Asian countries calls for breeding superior desi-type varieties, in turn necessitating the availability of characterized germplasm to breeders. The Indian National Genebank, located at the National Bureau of Plant Genetic Resources, New Delhi, conserves 14,651 accessions of chickpea. The entire set was characterized in a single large-scale experiment. High variation was observed for eight quantitative and 12 qualitative agro-morphological traits. Allelic richness procedure was employed to assemble a core set comprising 1103 accessions, 70.0% of which were of Indian origin. Comparable values of total variation explained by the first three principal components in the entire collection (51.1% and the core (52.4% together with conservation of nine pairwise r values among quantitative traits in the core collection and a coincidence rate around 99.7% indicated that the chickpea core was indeed an excellent representation of the entire chickpea collection in the National Genebank. The chickpea core exhibited greater diversity than the entire collection in agro-morphological traits, as assessed by higher variance and Shannon–Weaver diversity indices, indicating that the chickpea core maximized the phenotypic diversity available in the Indian chickpea germplasm. The chickpea core, comprising mainly indigenous desi genotypes, is expected to be an excellent resource for chickpea breeders. Information on the chickpea core can be accessed at http://www.nbpgr.ernet.in/pgrportal.

  9. Definition of a core set of quality indicators for the assessment of HIV/AIDS clinical care: a systematic review

    Science.gov (United States)

    2013-01-01

    Background Several organizations and individual authors have been proposing quality indicators for the assessment of clinical care in HIV/AIDS patients. Nevertheless, the definition of a consensual core set of indicators remains controversial and its practical use is largely limited. This study aims not only to identify and characterize these indicators through a systematic literature review but also to propose a parsimonious model based on those most used. Methods MEDLINE, SCOPUS, Cochrane databases and ISI Web of Knowledge, as well as official websites of organizations dealing with HIV/AIDS care, were searched for articles and information proposing HIV/AIDS clinical care quality indicators. The ones that are on patient’s perspective and based on services set were excluded. Data extraction, using a predefined data sheet based on Cochrane recommendations, was done by one of the authors while a second author rechecked the extracted data for any inconsistency. Results A total of 360 articles were identified in our search query but only 12 of them met the inclusion criteria. We also identified one relevant site. Overall, we identified 65 quality indicators for HIV/AIDS clinical care distributed as following: outcome (n=15) and process-related (n=50) indicators; generic (n=36) and HIV/AIDS disease-specific (n=29) indicators; baseline examinations (n=19), screening (n=9), immunization (n=4), prophylaxis (n=5), HIV monitoring (n=16), and therapy (=12) indicators. Conclusions There are several studies that set up HIV clinical care indicators, with only a part of them useful to assess the HIV clinical care. More importantly, HIV/AIDS clinical care indicators need to be valid, reliable and most of all feasible. PMID:23809537

  10. A review of patient and carer participation and the use of qualitative research in the development of core outcome sets.

    Science.gov (United States)

    Jones, Janet E; Jones, Laura L; Keeley, Thomas J H; Calvert, Melanie J; Mathers, Jonathan

    2017-01-01

    To be meaningful, a core outcome set (COS) should be relevant to all stakeholders including patients and carers. This review aimed to explore the methods by which patients and carers have been included as participants in COS development exercises and, in particular, the use and reporting of qualitative methods. In August 2015, a search of the Core Outcomes Measures in Effectiveness Trials (COMET) database was undertaken to identify papers involving patients and carers in COS development. Data were extracted to identify the data collection methods used in COS development, the number of health professionals, patients and carers participating in these, and the reported details of qualitative research undertaken. Fifty-nine papers reporting patient and carer participation were included in the review, ten of which reported using qualitative methods. Although patients and carers participated in outcome elicitation for inclusion in COS processes, health professionals tended to dominate the prioritisation exercises. Of the ten qualitative papers, only three were reported as a clear pre-designed part of a COS process. Qualitative data were collected using interviews, focus groups or a combination of these. None of the qualitative papers reported an underpinning methodological framework and details regarding data saturation, reflexivity and resource use associated with data collection were often poorly reported. Five papers reported difficulty in achieving a diverse sample of participants and two reported that a large and varied range of outcomes were often identified by participants making subsequent rating and ranking difficult. Consideration of the best way to include patients and carers throughout the COS development process is needed. Additionally, further work is required to assess the potential role of qualitative methods in COS, to explore the knowledge produced by different qualitative data collection methods, and to evaluate the time and resources required to

  11. Mapping the rehabilitation interventions of a community stroke team to the extended International Classification of Functioning, Disability and Health Core Set for Stroke.

    Science.gov (United States)

    Evans, Melissa; Hocking, Clare; Kersten, Paula

    2017-12-01

    This study aim was to evaluate whether the Extended International Classification of Functioning, Disability and Health Core Set for Stroke captured the interventions of a community stroke rehabilitation team situated in a large city in New Zealand. It was proposed that the results would identify the contribution of each discipline, and the gaps and differences in service provision to Māori and non-Māori. Applying the Extended International Classification of Functioning, Disability and Health Core Set for Stroke in this way would also inform whether this core set should be adopted in New Zealand. Interventions were retrospectively extracted from 18 medical records and linked to the International Classification of Functioning, Disability and Health and the Extended International Classification of Functioning, Disability and Health Core Set for Stroke. The frequencies of linked interventions and the health discipline providing the intervention were calculated. Analysis revealed that 98.8% of interventions provided by the rehabilitation team could be linked to the Extended International Classification of Functioning, Disability and Health Core Set for Stroke, with more interventions for body function and structure than for activities and participation; no interventions for emotional concerns; and limited interventions for community, social and civic life. Results support previous recommendations for additions to the EICSS. The results support the use of the Extended International Classification of Functioning, Disability and Health Core Set for Stroke in New Zealand and demonstrates its use as a quality assurance tool that can evaluate the scope and practice of a rehabilitation service. Implications for Rehabilitation The Extended International Classification of Functioning Disability and Health Core Set for Stroke appears to represent the stroke interventions of a community stroke rehabilitation team in New Zealand. As a result, researchers and clinicians may have

  12. Development of a Draft Core Set of Domains for Measuring Shared Decision Making in Osteoarthritis: An OMERACT Working Group on Shared Decision Making.

    Science.gov (United States)

    Toupin-April, Karine; Barton, Jennifer; Fraenkel, Liana; Li, Linda; Grandpierre, Viviane; Guillemin, Francis; Rader, Tamara; Stacey, Dawn; Légaré, France; Jull, Janet; Petkovic, Jennifer; Scholte-Voshaar, Marieke; Welch, Vivian; Lyddiatt, Anne; Hofstetter, Cathie; De Wit, Maarten; March, Lyn; Meade, Tanya; Christensen, Robin; Gaujoux-Viala, Cécile; Suarez-Almazor, Maria E; Boonen, Annelies; Pohl, Christoph; Martin, Richard; Tugwell, Peter S

    2015-12-01

    Despite the importance of shared decision making for delivering patient-centered care in rheumatology, there is no consensus on how to measure its process and outcomes. The aim of this Outcome Measures in Rheumatology (OMERACT) working group is to determine the core set of domains for measuring shared decision making in intervention studies in adults with osteoarthritis (OA), from the perspectives of patients, health professionals, and researchers. We followed the OMERACT Filter 2.0 method to develop a draft core domain set by (1) forming an OMERACT working group; (2) conducting a review of domains of shared decision making; and (3) obtaining opinions of all those involved using a modified nominal group process held at a session activity at the OMERACT 12 meeting. In all, 26 people from Europe, North America, and Australia, including 5 patient research partners, participated in the session activity. Participants identified the following domains for measuring shared decision making to be included as part of the draft core set: (1) identifying the decision, (2) exchanging information, (3) clarifying views, (4) deliberating, (5) making the decision, (6) putting the decision into practice, and (7) assessing the effect of the decision. Contextual factors were also suggested. We proposed a draft core set of shared decision-making domains for OA intervention research studies. Next steps include a workshop at OMERACT 13 to reach consensus on these proposed domains in the wider OMERACT group, as well as to detail subdomains and assess instruments to develop a core outcome measurement set.

  13. Development of a Draft Core Set of Domains for Measuring Shared Decision Making in Osteoarthritis: An OMERACT Working Group on Shared Decision Making

    Science.gov (United States)

    Toupin April, Karine; Barton, Jennifer; Fraenkel, Liana; Li, Linda; Grandpierre, Viviane; Guillemin, Francis; Rader, Tamara; Stacey, Dawn; Légaré, France; Jull, Janet; Petkovic, Jennifer; Scholte Voshaar, Marieke; Welch, Vivian; Lyddiatt, Anne; Hofstetter, Cathie; De Wit, Maarten; March, Lyn; Meade, Tanya; Christensen, Robin; Gaujoux-Viala, Cécile; Suarez-Almazor, Maria E.; Boonen, Annelies; Pohl, Christoph; Martin, Richard; Tugwell, Peter

    2015-01-01

    Objective Despite the importance of shared decision making for delivering patient-centred care in rheumatology, there is no consensus on how to measure its process and outcomes. The aim of this OMERACT working group is to determine the core set of domains for measuring shared decision making in intervention studies in adults with osteoarthritis (OA), from the perspective of patients, health professionals and researchers. Methods We followed the OMERACT Filter 2.0 to develop a draft core domain set, which consisted of: (i) forming an OMERACT working group; (ii) conducting a review of domains of shared decision making; and (iii) obtaining the opinions of stakeholders using a modified nominal group process held at a session activity at the OMERACT 2014 meeting. Results 26 stakeholders from Europe, North America and Australia, including 5 patient research partners, participated in the session activity. Participants identified the following domains for measuring shared decision making to be included as part of the Draft Core Set: 1) Identifying the decision; 2) Exchanging Information; 3) Clarifying views; 4) Deliberating; 5) Making the decision; 6) Putting the decision into practice; and 7) Assessing the impact of the decision. Contextual factors were also suggested. Conclusion We propose a Draft Core Set of shared decision making domains for OA intervention research studies. Next steps include a workshop at OMERACT 2016 to reach consensus on these proposed domains in the wider OMERACT group, as well as detail sub-domains and assess instruments to develop a Core Outcome Measurement Set. PMID:25877502

  14. Progress Towards a Core Set of Outcome Measures in Small-vessel Vasculitis. Report from OMERACT 9

    Science.gov (United States)

    MERKEL, PETER A.; HERLYN, KAREN; MAHR, ALFRED D.; NEOGI, TUHINA; SEO, PHILIP; WALSH, MICHAEL; BOERS, MAARTEN; LUQMANI, RAASHID

    2011-01-01

    The past decade has seen a substantial increase in the number and quality of clinical trials of new therapies for vasculitis, including randomized, controlled, multicenter trials that have successfully incorporated measures of disease activity and toxicity. However, because current treatment regimens for severe disease effectively induce initial remission and reduce mortality, future trials will focus on any of several goals including: (a) treatment of mild—moderate disease; (b) prevention of chronic damage; (c) reduction in treatment toxicity; or (d) more subtle differences in remission induction or maintenance. Thus, new trials will require outcome measure instruments that are more precise and are better able to detect effective treatments for different disease states and measure chronic manifestations of disease. The OMERACT Vasculitis Working Group comprises international clinical investigators with expertise in vasculitis who, since 2002, have worked collaboratively to advance the refinement of outcome measures in vasculitis, create new measures to address domains of illness not covered by current research approaches, and harmonize outcome assessment in vasculitis. The focus of the OMERACT group to date has been on outcome measures in small-vessel vasculitis with an overall goal of creating a core set of outcome measures for vasculitis, each of which fulfills the OMERACT filter of truth, discrimination, feasibility, and identifying additional domains requiring further research. This process has been informed by several ongoing projects providing data on outcomes of disease activity, disease-related damage, multidimensional health-related quality of life, and patient-reported ratings of the burden of vasculitis. PMID:19820226

  15. Developing an OMERACT Core Outcome Set for Assessing Safety Components in Rheumatology Trials: The OMERACT Safety Working Group.

    Science.gov (United States)

    Klokker, Louise; Tugwell, Peter; Furst, Daniel E; Devoe, Dan; Williamson, Paula; Terwee, Caroline B; Suarez-Almazor, Maria E; Strand, Vibeke; Woodworth, Thasia; Leong, Amye L; Goel, Niti; Boers, Maarten; Brooks, Peter M; Simon, Lee S; Christensen, Robin

    2017-12-01

    Failure to report harmful outcomes in clinical research can introduce bias favoring a potentially harmful intervention. While core outcome sets (COS) are available for benefits in randomized controlled trials in many rheumatic conditions, less attention has been paid to safety in such COS. The Outcome Measures in Rheumatology (OMERACT) Filter 2.0 emphasizes the importance of measuring harms. The Safety Working Group was reestablished at the OMERACT 2016 with the objective to develop a COS for assessing safety components in trials across rheumatologic conditions. The safety issue has previously been discussed at OMERACT, but without a consistent approach to ensure harms were included in COS. Our methods include (1) identifying harmful outcomes in trials of interventions studied in patients with rheumatic diseases by a systematic literature review, (2) identifying components of safety that should be measured in such trials by use of a patient-driven approach including qualitative data collection and statistical organization of data, and (3) developing a COS through consensus processes including everyone involved. Members of OMERACT including patients, clinicians, researchers, methodologists, and industry representatives reached consensus on the need to continue the efforts on developing a COS for safety in rheumatology trials. There was a general agreement about the need to identify safety-related outcomes that are meaningful to patients, framed in terms that patients consider relevant so that they will be able to make informed decisions. The OMERACT Safety Working Group will advance the work previously done within OMERACT using a new patient-driven approach.

  16. Can we decide which outcomes should be measured in every clinical trial? A scoping review of the existing conceptual frameworks and processes to develop core outcome sets.

    Science.gov (United States)

    Idzerda, Leanne; Rader, Tamara; Tugwell, Peter; Boers, Maarten

    2014-05-01

    The usefulness of randomized control trials to advance clinical care depends upon the outcomes reported, but disagreement on the choice of outcome measures has resulted in inconsistency and the potential for reporting bias. One solution to this problem is the development of a core outcome set: a minimum set of outcome measures deemed critical for clinical decision making. Within rheumatology the Outcome Measures in Rheumatology (OMERACT) initiative has pioneered the development of core outcome sets since 1992. As the number of diseases addressed by OMERACT has increased and its experience in formulating core sets has grown, clarification and update of the conceptual framework and formulation of a more explicit process of area/domain core set development has become necessary. As part of the update process of the OMERACT Filter criteria to version 2, a literature review was undertaken to compare and contrast the OMERACT conceptual framework with others within and outside rheumatology. A scoping search was undertaken to examine the extent, range, and nature of conceptual frameworks for core set outcome selection in health. We searched the following resources: Cochrane Library Methods Group Register; Medline; Embase; PsycInfo; Environmental Studies and Policy Collection; and ABI/INFORM Global. We also conducted a targeted Google search. Five conceptual frameworks were identified: the WHO tripartite definition of health; the 5 Ds (discomfort, disability, drug toxicity, dollar cost, and death); the International Classification of Functioning (ICF); PROMIS (Patient-Reported Outcomes Measurement System); and the Outcomes Hierarchy. Of these, only the 5 Ds and ICF frameworks have been systematically applied in core set development. Outside the area of rheumatology, several core sets were identified; these had been developed through a limited range of consensus-based methods with varying degrees of methodological rigor. None applied a framework to ensure content validity of

  17. Updating the Psoriatic Arthritis (PsA) Core Domain Set: A Report from the PsA Workshop at OMERACT 2016.

    Science.gov (United States)

    Orbai, Ana-Maria; de Wit, Maarten; Mease, Philip J; Callis Duffin, Kristina; Elmamoun, Musaab; Tillett, William; Campbell, Willemina; FitzGerald, Oliver; Gladman, Dafna D; Goel, Niti; Gossec, Laure; Hoejgaard, Pil; Leung, Ying Ying; Lindsay, Chris; Strand, Vibeke; van der Heijde, Désirée M; Shea, Bev; Christensen, Robin; Coates, Laura; Eder, Lihi; McHugh, Neil; Kalyoncu, Umut; Steinkoenig, Ingrid; Ogdie, Alexis

    2017-10-01

    To include the patient perspective in accordance with the Outcome Measures in Rheumatology (OMERACT) Filter 2.0 in the updated Psoriatic Arthritis (PsA) Core Domain Set for randomized controlled trials (RCT) and longitudinal observational studies (LOS). At OMERACT 2016, research conducted to update the PsA Core Domain Set was presented and discussed in breakout groups. The updated PsA Core Domain Set was voted on and endorsed by OMERACT participants. We conducted a systematic literature review of domains measured in PsA RCT and LOS, and identified 24 domains. We conducted 24 focus groups with 130 patients from 7 countries representing 5 continents to identify patient domains. We achieved consensus through 2 rounds of separate surveys with 50 patients and 75 physicians, and a nominal group technique meeting with 12 patients and 12 physicians. We conducted a workshop and breakout groups at OMERACT 2016 in which findings were presented and discussed. The updated PsA Core Domain Set endorsed with 90% agreement by OMERACT 2016 participants included musculoskeletal disease activity, skin disease activity, fatigue, pain, patient's global assessment, physical function, health-related quality of life, and systemic inflammation, which were recommended for all RCT and LOS. These were important, but not required in all RCT and LOS: economic cost, emotional well-being, participation, and structural damage. Independence, sleep, stiffness, and treatment burden were on the research agenda. The updated PsA Core Domain Set was endorsed at OMERACT 2016. Next steps for the PsA working group include evaluation of PsA outcome measures and development of a PsA Core Outcome Measurement Set.

  18. European validation of The Comprehensive International Classification of Functioning, Disability and Health Core Set for Osteoarthritis from the perspective of patients with osteoarthritis of the knee or hip.

    Science.gov (United States)

    Weigl, Martin; Wild, Heike

    2017-09-15

    To validate the International Classification of Functioning, Disability and Health Comprehensive Core Set for Osteoarthritis from the patient perspective in Europe. This multicenter cross-sectional study involved 375 patients with knee or hip osteoarthritis. Trained health professionals completed the Comprehensive Core Set, and patients completed the Short-Form 36 questionnaire. Content validity was evaluated by calculating prevalences of impairments in body function and structures, limitations in activities and participation and environmental factors, which were either barriers or facilitators. Convergent construct validity was evaluated by correlating the International Classification of Functioning, Disability and Health categories with the Short-Form 36 Physical Component Score and the SF-36 Mental Component Score in a subgroup of 259 patients. The prevalences of all body function, body structure and activities and participation categories were >40%, >32% and >20%, respectively, and all environmental factors were relevant for >16% of patients. Few categories showed relevant differences between knee and hip osteoarthritis. All body function categories and all but two activities and participation categories showed significant correlations with the Physical Component Score. Body functions from the ICF chapter Mental Functions showed higher correlations with the Mental Component Score than with the Physical Component Score. This study supports the validity of the International Classification of Functioning, Disability and Health Comprehensive Core Set for Osteoarthritis. Implications for Rehabilitation Comprehensive International Classification of Functioning, Disability and Health Core Sets were developed as practical tools for application in multidisciplinary assessments. The validity of the Comprehensive International Classification of Functioning, Disability and Health Core Set for Osteoarthritis in this study supports its application in European patients with

  19. Preliminary evaluation of a telephone-based smoking cessation intervention in the lung cancer screening setting: A randomized clinical trial.

    Science.gov (United States)

    Taylor, Kathryn L; Hagerman, Charlotte J; Luta, George; Bellini, Paula G; Stanton, Cassandra; Abrams, David B; Kramer, Jenna A; Anderson, Eric; Regis, Shawn; McKee, Andrea; McKee, Brady; Niaura, Ray; Harper, Harry; Ramsaier, Michael

    2017-06-01

    Incorporating effective smoking cessation interventions into lung cancer screening (LCS) programs will be essential to realizing the full benefit of screening. We conducted a pilot randomized trial to determine the feasibility and efficacy of a telephone-counseling (TC) smoking cessation intervention vs. usual care (UC) in the LCS setting. In collaboration with 3 geographically diverse LCS programs, we enrolled current smokers (61.5% participation rate) who were: registered to undergo LCS, 50-77 years old, and had a 20+ pack-year smoking history. Eligibility was not based on readiness to quit. Participants completed pre-LCS (T0) and post-LCS (T1) telephone assessments, were randomized to TC (N=46) vs. UC (N=46), and completed a final 3-month telephone assessment (T2). Both study arms received a list of evidence-based cessation resources. TC participants also received up to 6 brief counseling calls with a trained cessation counselor. Counseling calls incorporated motivational interviewing and utilized the screening result as a motivator for quitting. The outcome was biochemically verified 7-day point prevalence cessation at 3-months post-randomization. Participants (56.5% female) were 60.2 (SD=5.4) years old and reported 47.1 (SD=22.2) pack years; 30% were ready to stop smoking in the next 30 days. TC participants completed an average of 4.4 (SD=2.3) sessions. Using intent-to-treat analyses, biochemically verified quit rates were 17.4% (TC) vs. 4.3% (UC), p<.05. This study provides preliminary evidence that telephone-based cessation counseling is feasible and efficacious in the LCS setting. As millions of current smokers are now eligible for lung cancer screening, this setting represents an important opportunity to exert a large public health impact on cessation among smokers who are at very high risk for multiple tobacco-related diseases. If this evidence-based, brief, and scalable intervention is replicated, TC could help to improve the overall cost

  20. Development of a core outcome set for clinical trials in inflammatory bowel disease: study protocol for a systematic review of the literature and identification of a core outcome set using a Delphi survey.

    Science.gov (United States)

    Ma, Christopher; Panaccione, Remo; Fedorak, Richard N; Parker, Claire E; Khanna, Reena; Levesque, Barrett G; Sandborn, William J; Feagan, Brian G; Jairath, Vipul

    2017-06-09

    Crohn's disease (CD) and ulcerative colitis (UC), the main forms of inflammatory bowel disease (IBD), are chronic, progressive and disabling disorders of the gastrointestinal tract. Although data from randomised controlled trials (RCTs) provide the foundation of evidence that validates medical therapy for IBD, considerable heterogeneity exists in the measured outcomes used in these studies. Furthermore, in recent years, there has been a paradigm shift in IBD treatment targets, moving from symptom-based scoring to improvement or normalisation of objective measures of inflammation such as endoscopic appearance, inflammatory biomarkers and histological and radiographic end points. The abundance of new treatment options and evolving end points poses opportunities and challenges for all stakeholders involved in drug development. Accordingly, there exists a need to harmonise measures used in clinical trials through the development of a core outcome set (COS). The development of an IBD-specific COS includes four steps. First, a systematic literature review is performed to identify outcomes previously used in IBD RCTs. Second, semistructured qualitative interviews are conducted with key stakeholders, including patients, clinicians, researchers, pharmaceutical industry representatives, healthcare payers and regulators to identify additional outcomes of importance. Using the outcomes generated from literature review and stakeholder interviews, an international two-round Delphi survey is conducted to prioritise outcomes for inclusion in the COS. Finally, a consensus meeting is held to ratify the COS and disseminate findings for application in future IBD trials. Given that over 30 novel therapeutic compounds are in development for IBD treatment, the design of robust clinical trials measuring relevant and standardised outcomes is crucial. Standardising outcomes through a COS will reduce heterogeneity in trial reporting, facilitate valid comparisons of new therapies and improve

  1. Preliminary scoping safety analyses of the limiting design basis protected accidents for the Fast Flux Test Facility tritium production core

    International Nuclear Information System (INIS)

    Heard, F.J.

    1997-01-01

    The SAS4A/SASSYS-l computer code is used to perform a series of analyses for the limiting protected design basis transient events given a representative tritium and medical isotope production core design proposed for the Fast Flux Test Facility. The FFTF tritium and isotope production mission will require a different core loading which features higher enrichment fuel, tritium targets, and medical isotope production assemblies. Changes in several key core parameters, such as the Doppler coefficient and delayed neutron fraction will affect the transient response of the reactor. Both reactivity insertion and reduction of heat removal events were analyzed. The analysis methods and modeling assumptions are described. Results of the analyses and comparison against fuel pin performance criteria are presented to provide quantification that the plant protection system is adequate to maintain the necessary safety margins and assure cladding integrity

  2. Preliminary evaluation of SACI-O code for the analysis of transients in a pressurized water reactor core

    International Nuclear Information System (INIS)

    Soares, P.A.; Sirimarco, L.F.; Veloso, M.A.F.

    1979-03-01

    SACI-O is a computer code which deals with the dynamics of the core of pressurized light water reactors (PWR). Its applicability is determined by the evaluation of the models used in the simulation of the several phenomena and processes which occur in the core during transients. This report presents a comparison between the results obtained with SACI-O and those presented in the Final Safety Analysis Report (FSAR) of Angra dos Reis Nuclear Station, Unit 1. Although some data used in the calculations done by Westinghouse are not known, there was a good agreement between the mentioned results. (Author) [pt

  3. Small Steps: Preliminary effectiveness and feasibility of an incremental goal-setting intervention to reduce sitting time in older adults.

    Science.gov (United States)

    Lewis, L K; Rowlands, A V; Gardiner, P A; Standage, M; English, C; Olds, T

    2016-03-01

    This study aimed to evaluate the preliminary effectiveness and feasibility of a theory-informed program to reduce sitting time in older adults. Pre-experimental (pre-post) study. Thirty non-working adult (≥ 60 years) participants attended a one hour face-to-face intervention session and were guided through: a review of their sitting time; normative feedback on sitting time; and setting goals to reduce total sitting time and bouts of prolonged sitting. Participants chose six goals and integrated one per week incrementally for six weeks. Participants received weekly phone calls. Sitting time and bouts of prolonged sitting (≥ 30 min) were measured objectively for seven days (activPAL3c inclinometer) pre- and post-intervention. During these periods, a 24-h time recall instrument was administered by computer-assisted telephone interview. Participants completed a post-intervention project evaluation questionnaire. Paired t tests with sequential Bonferroni corrections and Cohen's d effect sizes were calculated for all outcomes. Twenty-seven participants completed the assessments (71.7 ± 6.5 years). Post-intervention, objectively-measured total sitting time was significantly reduced by 51.5 min per day (p=0.006; d=-0.58) and number of bouts of prolonged sitting by 0.8 per day (p=0.002; d=-0.70). Objectively-measured standing increased by 39 min per day (p=0.006; d=0.58). Participants self-reported spending 96 min less per day sitting (p<0.001; d=-0.77) and 32 min less per day watching television (p=0.005; d=-0.59). Participants were highly satisfied with the program. The 'Small Steps' program is a feasible and promising avenue for behavioral modification to reduce sitting time in older adults. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  4. Current Status of the Transmutation Reactor Technology and Preliminary Evaluation of Transmutation Performance of the KALIMER Core

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Ser Gi; Sim, Yoon Sub; Kim, Yeong Il; Kim, Young Gyum; Lee, Byung Woon; Song, Hoon; Lee, Ki Bog; Jang, Jin Wook; Lee, Dong Uk

    2005-08-15

    Recently the most countries using the nuclear power plants for electricity generation have been faced with the problem of the preparation of the repository for the disposition of the nuclear waste generated from LWR. It was well-known that the issues related with long term risk of the radioactive wastes for the future generations are due only to 1% of the total waste. This small fraction of 1% consists of transuranic (TRU) nuclides such as Pu, Np, Am, Cm and the long lived fission products such as Tc and I. For the transuranic (TRU) nuclides, their half lives range from several years to several hundred thousands years and hence their radioactive toxicity can be lasted over very long time period. This has made the change of the rule of the fast spectrum reactor from the economical use of uranium resource through breeding to the reduction of the nuclear waste through the transmutation. The purpose of this study is to obtain the basic knowledge on the nuclear transmutation technology and to suggest the technical solution ways for the future technology development and enhancement through a survey of the state-of-art of the international research on the nuclear transmutation. The increase of the transmutation rate requires the reduction of the breeding ratio. In fact, the transmutation rate is determined by the breeding ratio. The reduction of the breeding ratio can be achieved by reducing the U-238 content in fuel or increasing the neutron leakage through core boundary or absorbing the neutrons by using some absorbers. However, the reduction of the U-238 content results in the degradation of the fuel Doppler coefficient that is one of the most important safety-related parameters and the reduction of the effective delayed neutron fraction that is related with the controllability of the reactor core. Also, the increase of the transmutation rate can lead to the increase of the coolant void reactivity worth unless some ways to reduce the coolant void reactivity are not

  5. Determination of three-dimensional stress orientations in the Wenchuan earthquake Fault Scientific Drilling (WFSD) hole-1: A preliminary result by anelastic strain recovery measurements of core samples

    Science.gov (United States)

    Cui, J.; Lin, W.; Wang, L.; Tang, Z.; Sun, D.; Gao, L.; Wang, W.

    2010-12-01

    A great and destructive earthquake (Ms 8.0; Mw 7.9), Wunchuan earthquake struck on the Longmen Shan foreland trust zone in Sichuan province, China on 12 May 2008 (Xu et al., 2008; Episodes, Vol.31, pp.291-301). As a rapid response scientific drilling project, Wenchuan earthquake Fault Scientific Drilling (WFSD) started on 6 November 2008 shorter than a half of year from the date of earthquake main shock. The first pilot borehole (hole-1) has been drilled to the target depth (measured depth 1201 m MD, vertical depth 1179 m) at Hongkou, Dujianyan, Sichuan and passed through the main fault of the earthquake around 589 m MD. We are trying to determine three dimensional in-situ stress states in the WFSD boreholes by a core-based method, anelastic strain recovery (ASR) method (Lin et al., 2006; Tectonophysics, Vol4.26, pp.221-238). This method has been applied in several scientific drilling projects (TCDP: Lin et al., 2007; TAO, Vol.18, pp.379-393; NanTtoSEIZE: Byrne et al., 2009; GRL, Vol.36, L23310). These applications confirm the validity of using the ASR technique in determining in situ stresses by using drilled cores. We collected total 15 core samples in a depth range from 340 m MD to 1180 m MD, approximately for ASR measurements. Anelastic normal strains, measured every ten minutes in nine directions, including six independent directions, were used to calculate the anelastic strain tensors. The data of the ASR tests conducted at hole-1 is still undergoing analysis. As a tentative perspective, more than 10 core samples showed coherent strain recovery over one - two weeks. However, 2 or 3 core samples cannot be re-orientated to the global system. It means that we cannot rink the stress orientation determined by the core samples to geological structure. Unfortunately, a few core samples showed irregular strain recovery and were not analyzed further. The preliminary results of ASR tests at hole-1 show the stress orientations and stress regime changes a lot with the

  6. Exploring the comparative responsiveness of a core set of outcome measures in a school-based conductive education programme.

    Science.gov (United States)

    Wright, F V; Boschen, K; Jutai, J

    2005-05-01

    Conductive education (CE) is a holistic educational system that uses an active cognitive approach to teach individuals with motor disorders to become more functional participants in daily activities. While CE's popularity continues to grow in North America and Europe, its effectiveness has not been established. The lack of definition of responsive outcome measures for evaluation of CE programmes has limited the interpretability of conclusions from earlier studies evaluating effectiveness. To determine which measures from a core set were most responsive to physical, functional and psychosocial changes associated with a school-based CE programme. This was a one-group before and after data collection design using an 8-month follow-up period. We enrolled a referral sample of nine children with cerebral palsy in Kindergarten or Grade 1 (Gross Motor Function Classification System levels 3, 4 or 5). The study took place within a school-based CE programme at a Canadian children's rehabilitation centre. Children participated in a CE full-day class for an entire school year. Physical, functional, psychosocial and participation measures included: Gross Motor Function Measure (GMFM), Quality of Upper Extremity Skills Test (QUEST), Peabody Developmental Motor Scales, Paediatric Evaluation of Disability Inventory (PEDI), Pictorial Scale of Perceived Competence and Social Acceptance for Young Children, Individualized Educational Plan, and Goal Attainment Scaling (GAS). Four children from the study's second year were also evaluated on the Impact on Family Scale (IFS), GAS and School Function Assessment. The Gross Motor Function Measure, QUEST, PEDI (Caregiver Assistance) and IFS were most responsive to change. GAS was useful in documenting and quantifying goals. Problems were encountered in evaluating self-esteem and school participation. Several strong measures of outcome were identified. Further work is needed to find valid and sensitive psychosocial and school participation

  7. Marine historical ecology at the Brijuni Islands, Croatia: preliminary results from down-core changes of foraminiferal assemblages

    Science.gov (United States)

    Vidovic, Jelena; Cosovic, Vlasta; Gallmetzer, Ivo; Haselmair, Alexandra; Zuschin, Martin

    2015-04-01

    The Late Holocene in the northern Adriatic is characterized by the eustatic peak of the sea-level rise, followed by the equilibrium between the regional tectonic subsidence and hydro-isostatic emergence and relatively stable sea level for a few thousand years. During this period the area experienced changes in sedimentation rate, food/oxygen availability in the benthic ecosystem and eutrophication with seasonal hypoxic and anoxic events. In order to reconstruct the marine paleoecology in the Brijuni Islands area during this period, a multidisciplinary study was carried out, including geochemical (TOC, trace metals, carbonate content), micropaleontological analyses (benthic foraminifera) and dating of sediments and mollusc shells. The principal aim of this study is to observe the effects of ecological shifts on foraminiferal assemblages during the Late Holocene. One core of 1.5 m length was taken at a sampling station south of Veli Brijuni Island, located within a marine protected area with no fishing/dredging pressure (Croatian national park). The core was sliced into smaller subsamples, and four sediment fractions of each subsample (63, 125, 250 and 500 µm) were analyzed for standard properties of the foraminiferal community (species richness, faunal composition, biodiversity indices), in comparison with relevant physical and geochemical properties of the sediment. The results concerning changes in foraminiferal species composition and abundance point to differences within the core: surface sediments are dominated by suspension feeders (Planorbulina mediterranensis, Lobatula lobatula, Cibicides variabilis, Cibicides refulgens), whereas deposit feeders (genera Textularia, Siphonaperta, Adelosina, Trioculina) appear in higher abundances at approximately 30 cm of the sediment depth and dominate down-core. Species richness in the first 30 cm is lower (10 to 34 species per sample) in comparison to the middle part of the core (39 to 53 species), and decreases again at

  8. [The International Classification of Functioning, Disability and Health (ICF) : The implementation of the ICF Core Sets for Hand Conditions in clinical routine as an example of application].

    Science.gov (United States)

    Coenen, Michaela; Rudolf, Klaus-Dieter; Kus, Sandra; Dereskewitz, Caroline

    2018-05-24

    The International Classification of Functioning, Disability and Health (ICF) provides a standardized language of almost 1500 ICF categories for coding information about functioning and contextual factors. Short lists (ICF Core Sets) are helpful tools to support the implementation of the ICF in clinical routine. In this paper we report on the implementation of ICF Core Sets in clinical routine using the "ICF Core Sets for Hand Conditions" and the "Lighthouse Project Hand" as an example. Based on the ICF categories of the "Brief ICF Core Set for Hand Conditions", the ICF-based assessment tool (ICF Hand A ) was developed aiming to guide the assessment and treatment of patients with injuries and diseases located at the hand. The ICF Hand A facilitates the standardized assessment of functioning - taking into consideration of a holistic view of the patients - along the continuum of care ranging from acute care to rehabilitation and return to work. Reference points for the assessment of the ICF Hand A are determined in treatment guidelines for selected injuries and diseases of the hand along with recommendations for acute treatment and care, procedures and interventions of subsequent treatment and rehabilitation. The assessment of the ICF Hand A according to the defined reference points can be done using electronic clinical assessment tools and allows for an automatic generation of a timely medical report of a patient's functioning. In the future, the ICF Hand A can be used to inform the coding of functioning in ICD-11.

  9. Identification of a Core Set of Exercise Tests for Children and Adolescents with Cerebral Palsy: A Delphi Survey of Researchers and Clinicians

    Science.gov (United States)

    Verschuren, Olaf; Ketelaar, Marjolijn; Keefer, Daniel; Wright, Virginia; Butler, Jane; Ada, Louise; Maher, Carol; Reid, Siobhan; Wright, Marilyn; Dalziel, Blythe; Wiart, Lesley; Fowler, Eileen; Unnithan, Viswanath; Maltais, Desiree B.; van den Berg-Emons, Rita; Takken, Tim

    2011-01-01

    Aim: Evidence-based recommendations regarding which exercise tests to use in children and adolescents with cerebral palsy (CP) are lacking. This makes it very difficult for therapists and researchers to choose the appropriate exercise-related outcome measures for this group. This study aimed to identify a core set of exercise tests for children…

  10. The Geriatric ICF Core Set reflecting health-related problems in community-living older adults aged 75 years and older without dementia : development and validation

    NARCIS (Netherlands)

    Spoorenberg, Sophie L. W.; Reijneveld, Sijmen A.; Middel, Berrie; Uittenbroek, Ronald J.; Kremer, Hubertus P. H.; Wynia, Klaske

    2015-01-01

    Purpose: The aim of the present study was to develop a valid Geriatric ICF Core Set reflecting relevant health-related problems of community-living older adults without dementia. Methods: A Delphi study was performed in order to reach consensus (70% agreement) on second-level categories from the

  11. Identification of candidate categories of the International Classification of Functioning Disability and Health (ICF for a Generic ICF Core Set based on regression modelling

    Directory of Open Access Journals (Sweden)

    Üstün Bedirhan T

    2006-07-01

    Full Text Available Abstract Background The International Classification of Functioning, Disability and Health (ICF is the framework developed by WHO to describe functioning and disability at both the individual and population levels. While condition-specific ICF Core Sets are useful, a Generic ICF Core Set is needed to describe and compare problems in functioning across health conditions. Methods The aims of the multi-centre, cross-sectional study presented here were: a to propose a method to select ICF categories when a large amount of ICF-based data have to be handled, and b to identify candidate ICF categories for a Generic ICF Core Set by examining their explanatory power in relation to item one of the SF-36. The data were collected from 1039 patients using the ICF checklist, the SF-36 and a Comorbidity Questionnaire. ICF categories to be entered in an initial regression model were selected following systematic steps in accordance with the ICF structure. Based on an initial regression model, additional models were designed by systematically substituting the ICF categories included in it with ICF categories with which they were highly correlated. Results Fourteen different regression models were performed. The variance the performed models account for ranged from 22.27% to 24.0%. The ICF category that explained the highest amount of variance in all the models was sensation of pain. In total, thirteen candidate ICF categories for a Generic ICF Core Set were proposed. Conclusion The selection strategy based on the ICF structure and the examination of the best possible alternative models does not provide a final answer about which ICF categories must be considered, but leads to a selection of suitable candidates which needs further consideration and comparison with the results of other selection strategies in developing a Generic ICF Core Set.

  12. Validated Outcomes in the Grafting of Autologous Fat to the Breast: The VOGUE Study. Development of a Core Outcome Set for Research and Audit.

    Science.gov (United States)

    Agha, Riaz A; Pidgeon, Thomas E; Borrelli, Mimi R; Dowlut, Naeem; Orkar, Ter-Er K; Ahmed, Maziyah; Pujji, Ojas; Orgill, Dennis P

    2018-05-01

    Autologous fat grafting is an important part of the reconstructive surgeon's toolbox when treating women affected by breast cancer and subsequent tumor extirpation. The debate over safety and efficacy of autologous fat grafting continues within the literature. However, work performed by the authors' group has shown significant heterogeneity in outcome reporting. Core outcome sets have been shown to reduce heterogeneity in outcome reporting. The authors' goal was to develop a core outcome set for autologous fat grafting in breast reconstruction. The authors published their protocol a priori. A Delphi consensus exercise among key stakeholders was conducted using a list of outcomes generated from their previous work. These outcomes were divided into six domains: oncologic, clinical, aesthetic and functional, patient-reported, process, and radiologic. In the first round, 55 of 78 participants (71 percent) completed the Delphi consensus exercise. Consensus was reached on nine of the 13 outcomes. The clarity of the results and lack of additional suggested outcomes deemed further rounds to be unnecessary. The VOGUE Study has led to the development of a much-needed core outcome set in the active research front and clinical area of autologous fat grafting. The authors hope that clinicians will use this core outcome set to audit their practice, and that researchers will implement these outcomes in their study design and reporting of autologous fat grafting outcomes. The authors encourage journals and surgical societies to endorse and encourage use of this core outcome set to help refine the scientific quality of the debate, the discourse, and the literature. Therapeutic, V.

  13. Survey indicated that core outcome set development is increasingly including patients, being conducted internationally and using Delphi surveys.

    Science.gov (United States)

    Biggane, Alice M; Brading, Lucy; Ravaud, Philippe; Young, Bridget; Williamson, Paula R

    2018-02-17

    There are numerous challenges in including patients in a core outcome set (COS) study, these can vary depending on the patient group. This study describes current efforts to include patients in the development of COS, with the aim of identifying areas for further improvement and study. Using the COMET database, corresponding authors of COS projects registered or published from 1 January 2013 to 2 February 2017 were invited via a personalised email to participate in a short online survey. The survey and emails were constructed to maximise the response rate by following the academic literature on enhancing survey responses. Personalised reminder emails were sent to non-responders. This survey explored the frequency of patient input in COS studies, who was involved, what methods were used and whether or not the COS development was international. One hundred and ninety-two COS developers were sent the survey. Responses were collected from 21 February 2017 until 7 May 2017. One hundred and forty-six unique developers responded, yielding a 76% response rate and data in relation to 195 unique COSs (as some developers had worked on multiple COSs). Of focus here are their responses regarding 162 COSs at the published, completed or ongoing stages of development. Inclusion of patient participants was indicated in 87% (141/162) of COSs in the published completed or ongoing stages and over 94% (65/69) of ongoing COS projects. Nearly half (65/135) of COSs included patient participants from two or more countries and 22% (30/135) included patient participants from five or more countries. The Delphi survey was reported as being used singularly or in combination with other methods in 85% (119/140) of projects. Almost a quarter (16/65) of ongoing studies reported using a combination of qualitative interviews, Delphi survey and consensus meeting. These findings indicated that the Delphi survey is the most popular method of facilitating patient participation, while the combination of

  14. An assessment of the preliminary microbiological studies on clay cores from Elstow conducted by the Universities of Leicester and Warwick

    International Nuclear Information System (INIS)

    Rushbrook, P.E.

    1987-04-01

    Two preliminary studies were conducted to establish the presence or absence of micro-organisms in samples of Oxford Clay from Elstow. Bacterial colonies were the dominant organisms found. In addition, a limited series of tests was performed to assess the tolerance of specific bacterial sub-cultures to variations in two environmental parameters; pH and temperature. It was found that micro-organisms can survive and colonise at depth in Oxford Clay strata, but at an abundance of between two and four orders of magnitude below that of typical garden soil. Therefore, in the ''after closure'' phase of a repository where an environment of pH greater than 9 will probably exist, some localised micro-biological action may take place. However, from the data obtained, degradation by this mechanism is likely to be slower when compared to deterioration from physical and chemical mechanisms. (author)

  15. Preliminary biological sampling of GT3 and BT1 cores and the microbial community dynamics of existing subsurface wells

    Science.gov (United States)

    Kraus, E. A.; Stamps, B. W.; Rempfert, K. R.; Ellison, E. T.; Nothaft, D. B.; Boyd, E. S.; Templeton, A. S.; Spear, J. R.

    2017-12-01

    Subsurface microbial life is poorly understood but potentially very important to the search for life on other planets as well as increasing our understanding of Earth's geobiological processes. Fluids and rocks of actively serpentinizing subsurface environments are a recent target of biological study due to their apparent ubiquity across the solar system. Areas of serpentinization can contain high concentrations of molecular hydrogen, H2, that can serve as the dominant fuel source for subsurface microbiota. Working with the Oman Drilling Project, DNA and RNA were extracted from fluids of seven alkaline wells and two rock cores from drill sites GT3 and BT1 within the Samail ophiolite. DNA and cDNA (produced via reverse transcription from the recovered RNA) were sequenced using universal primers to identify microbial life across all three domains. Alkaline subsurface fluids support a microbial community that changes with pH and host-rock type. In peridotite with pH values of >11, wells NSHQ 14 and WAB 71 have high relative abundances of Meiothermus, Methanobacterium, the family Nitrospiraceae, and multiple types of the class Dehalococcoidia. While also hosted in peridotite but at pH 8.5, wells WAB 104 and 105 have a distinct, more diverse microbial community. This increased variance in community make-up is seen in wells that sit near/at the contact of gabbro and peridotite formations as well. Core results indicate both sampled rock types host a very low biomass environment subject to multiple sources of contamination during the drilling process. Suggestions for contaminant reduction, such as having core handlers wear nitrile gloves and flame-sterilizing the outer surfaces of core rounds for biological sampling, would have minimal impact to overall ODP coreflow and maximize the ability to better understand in situ microbiota in this low-biomass serpentinizing subsurface environment. While DNA extraction was successful with gram amounts of crushed rock, much can be

  16. Using a profile of a modified Brief ICF Core Set for chronic widespread musculoskeletal pain with qualifiers for baseline assessment in interdisciplinary pain rehabilitation

    Directory of Open Access Journals (Sweden)

    Löfgren M

    2013-08-01

    Full Text Available Monika Löfgren,1,2 Jan Ekholm,2 Lisbet Broman,3 Philipe Njoo,1 Marie-Louise Schult1–3 1Department of Rehabilitation Medicine Stockholm, Danderyd University Hospital, Sweden; 2Karolinska Institutet, Division of Rehabilitation Medicine, Department of Clinical Sciences, Danderyd University Hospital, Stockholm, Sweden; 3Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Stockholm, Sweden Aim: To describe the use of a “workable” visual profile of function and disability, based on a modified Brief International Classification of Functioning, Disability and Health (ICF Core Set for chronic widespread pain, for initial assessments in a clinical setting of interdisciplinary pain rehabilitation teams. Method: The Brief ICF Core Set was slightly adapted to meet the needs of an interdisciplinary rehabilitation medicine team working in a university outpatient clinic and admitting patients referred from primary care. The Core Set categories were made measurable by means of eg, assessment instruments and clinical investigations. The resulting profile was given a workable shape to facilitate rapid understanding of the initial assessment outcome. Results: Individual patients showed different profiles of problems and resources, which facilitated individual rehabilitation planning. At the level of the study group, the profiles for the Core Set component Body Functions showed that most patients had severe impairment in the sensation of pain and exercise tolerance categories of function, but most had resources in the motivation and memory categories of function. Likewise, for the component Activities, most patients had limitations in lifting and carrying objects and remunerative employment, but most had resources in intimate relationships and family relationships. At first, the use of the modified Brief ICF Core Set in the team conference was rather time consuming, but after a couple of months of experience, the team assessment took

  17. Crystallization and preliminary X-ray analysis of the major peanut allergen Ara h 1 core region

    International Nuclear Information System (INIS)

    Cabanos, Cerrone; Urabe, Hiroyuki; Masuda, Taro; Tandang-Silvas, Mary Rose; Utsumi, Shigeru; Mikami, Bunzo; Maruyama, Nobuyuki

    2010-01-01

    In this study, the core region of Ara h 1, one of the major peanut allergens, has been overexpressed in Escherichia coli, purified and crystallized. Diffraction data were collected to 2.25 Å resolution. Peanuts contain some of the most potent food allergens known to date. Ara h 1 is one of the three major peanut allergens. As a first step towards three-dimensional structure elucidation, recombinant Ara h 1 core region was cloned, expressed in Escherichia coli and purified to homogeneity. Crystals were obtained using 0.1 M sodium citrate pH 5.6, 0.1 M NaCl, 15% PEG 400 as precipitant. The crystals diffracted to 2.25 Å resolution using synchrotron radiation and belonged to the monoclinic space group C2, with unit-cell parameters a = 156.521, b = 88.991, c = 158.971 Å, β = 107.144°. Data were collected at the BL-38B1 station of SPring-8 (Hyogo, Japan)

  18. Imitation (rather than core language) predicts pragmatic development in young children with ASD: a preliminary longitudinal study using CDI parental reports.

    Science.gov (United States)

    Miniscalco, Carmela; Rudling, Maja; Råstam, Maria; Gillberg, Christopher; Johnels, Jakob Åsberg

    2014-01-01

    Research in the last decades has clearly pointed to the important role of language and communicative level when trying to understand developmental trajectories in children with autism spectrum disorders (ASD). The purpose of this longitudinal study was to investigate whether (1) core language skills, measured as expressive vocabulary and grammar, and/or (2) pre-linguistic social-communicative skills, including gestures and imitation abilities, drive pragmatic language development in young children with ASD. We examined correlates and longitudinal predictors of pragmatic growth in a sample of 34 children with Autism spectrum disorder (ASD), whose parents were given parts of two MacArthur Communicative Developmental Inventories (CDI: Words & Gestures and CDI: Words & Sentences) for completion at two time points (at time 1 the mean child age was 41 months, and at time 2 it was 54 months). A novel feature in this study is that the relevant parts from both CDI forms were included at both time points, allowing us to examine whether pre-linguistic social-communication skills (e.g. imitation and gesturing) and/or core language skills (i.e. grammar and vocabulary) predict pragmatic language growth. The results show that basically all pre-linguistic, linguistic and pragmatic skills were associated concurrently. When controlling for possible confounders and for the autoregressive effect, imitation skills predicted pragmatic growth over time, whereas core language did not. This could only have been shown by the use of both CDI forms. This preliminary study may be of both conceptual and methodological importance for research in the field of language and communication development in ASD. Imitation may play a pivotal role in the development of subsequent conversational pragmatic abilities in young children with ASD. Future research should be directed at unravelling the mechanisms underlying this association. © 2014 Royal College of Speech and Language Therapists.

  19. Using the International Classification of Functioning, Disability, and Health to identify outcome domains for a core outcome set for aphasia: a comparison of stakeholder perspectives.

    Science.gov (United States)

    Wallace, Sarah J; Worrall, Linda; Rose, Tanya; Le Dorze, Guylaine

    2017-11-12

    This study synthesised the findings of three separate consensus processes exploring the perspectives of key stakeholder groups about important aphasia treatment outcomes. This process was conducted to generate recommendations for outcome domains to be included in a core outcome set for aphasia treatment trials. International Classification of Functioning, Disability, and Health codes were examined to identify where the groups of: (1) people with aphasia, (2) family members, (3) aphasia researchers, and (4) aphasia clinicians/managers, demonstrated congruence in their perspectives regarding important treatment outcomes. Codes were contextualized using qualitative data. Congruence across three or more stakeholder groups was evident for ICF chapters: Mental functions; Communication; and Services, systems, and policies. Quality of life was explicitly identified by clinicians/managers and researchers, while people with aphasia and their families identified outcomes known to be determinants of quality of life. Core aphasia outcomes include: language, emotional wellbeing, communication, patient-reported satisfaction with treatment and impact of treatment, and quality of life. International Classification of Functioning, Disability, and Health coding can be used to compare stakeholder perspectives and identify domains for core outcome sets. Pairing coding with qualitative data may ensure important nuances of meaning are retained. Implications for rehabilitation The outcomes measured in treatment research should be relevant to stakeholders and support health care decision making. Core outcome sets (agreed, minimum set of outcomes, and outcome measures) are increasingly being used to ensure the relevancy and consistency of the outcomes measured in treatment studies. Important aphasia treatment outcomes span all components of the International Classification of Functioning, Disability, and Health. Stakeholders demonstrated congruence in the identification of important

  20. Preliminary analysis of control rod accidents in the CRCN-R1 multipurpose reactor core of Recife in Brazil

    International Nuclear Information System (INIS)

    Souza dos Santos, Rubens; Rubens Maiorino, Jose

    1999-01-01

    The paper shows some results of the neutronic accident analyses arisen by uncontrolled control rod withdrawal, based on the Conceptual Project of the CRCN-R1 MultiPurpose Reactor of Recife. In that reactor, a project of the CNEN/Brazil, under the leadership of the IPEN/Sao Paulo, is verified the thermal hydraulic limits in the reactor core during transients that simulate startup and power operation accidents. It has utilized a computer program that solved the kinetic equations based on multigroup diffusion theory, in our case we have used 4 energy groups, Two-Dimensional X-Y in the space, and 6 groups of delayed neutrons. A simple model of feedback is admitted in the capture and scattering macroscopic cross sections, in the fuel regions, temperature and coolant densities dependents. Based on those models, the results demonstrated that the reactor exhibits good degree of safety. (author)

  1. Design and preliminary analysis of in-vessel core catcher made of high-temperature ceramics material in PWR

    International Nuclear Information System (INIS)

    Xu Hong; Ma Li; Wang Junrong; Zhou Zhiwei

    2011-01-01

    In order to protect the interior wall of pressure vessel from melting, as an additional way to external reactor vessel cooling (ERVC), a kind of in-vessel core catcher (IVCC) made of high-temperature ceramics material was designed. Through the high-temperature and thermal-resistance characteristic of IVCC, the distributing of heat flux was optimized. The results show that the downward average heat flux from melt in ceramic layer reduces obviously and the interior wall of pressure vessel doesn't melt, keeping its integrity perfectly. Increasing of upward heat flux from metallic layer makes the upper plenum structure's temperature ascend, but the temperature doesn't exceed its melting point. In conclusion, the results indicate the potential feasibility of IVCC made of high-temperature ceramics material. (authors)

  2. Purification, crystallization and preliminary X-ray diffraction study of human ribosomal protein L10 core domain

    International Nuclear Information System (INIS)

    Nishimura, Mitsuhiro; Kaminishi, Tatsuya; Kawazoe, Masahito; Shirouzu, Mikako; Takemoto, Chie; Yokoyama, Shigeyuki; Tanaka, Akiko; Sugano, Sumio; Yoshida, Takuya; Ohkubo, Tadayasu; Kobayashi, Yuji

    2007-01-01

    A truncated variant of human ribosomal protien L10 was prepared and crystallized. Diffraction data were collected to 2.5 Å resolution. Eukaryotic ribosomal protein L10 is an essential component of the large ribosomal subunit, which organizes the architecture of the aminoacyl-tRNA binding site. The human L10 protein is also called the QM protein and consists of 214 amino-acid residues. For crystallization, the L10 core domain (L10CD, Phe34–Glu182) was recombinantly expressed in Escherichia coli and purified to homogeneity. A hexagonal crystal of L10CD was obtained by the sitting-drop vapour-diffusion method. The L10CD crystal diffracted to 2.5 Å resolution and belongs to space group P3 1 21 or P3 2 21

  3. Computer code and users' guide for the preliminary analysis of dual-mode space nuclear fission solid core power and propulsion systems, NUROC3A. AMS report No. 1239b

    Energy Technology Data Exchange (ETDEWEB)

    Nichols, R.A.; Smith, W.W.

    1976-06-30

    The three-volume report describes a dual-mode nuclear space power and propulsion system concept that employs an advanced solid-core nuclear fission reactor coupled via heat pipes to one of several electric power conversion systems. The second volume describes the computer code and users' guide for the preliminary analysis of the system.

  4. Characterization of atmospheric trace elements in the Puruogangri ice core: a preliminary account of Tibetan Plateau environmental and contamination histories

    Science.gov (United States)

    Beaudon, E.; Gabrielli, P.; Sierra Hernandez, R.; Wegner, A.; Thompson, L. G.

    2014-12-01

    Asia is facing enormous challenges including large-scale environmental changes, rapid population growth and industrialization. The inherent generated pollution contributes to half of all Earth's anthropogenic trace metals emissions that, when deposited to glaciers of the surrounding mountains of the Third Pole region, leave a characteristic chemical fingerprint. Records of past atmospheric deposition preserved in snow and ice from Third Pole glaciers provide unique insights into changes of the chemical composition of the atmosphere and into the nature and intensity of the regional atmospheric circulation systems. The determination of the elemental composition of aeolian dust stored in Himalayan and Tibetan Plateau glaciers can help to qualify the potential contamination of glacial meltwater as a part of the greater fresh Asian water source. The 215 m long Puruogangri ice core retrieved in 2000 at 6500 m a.s.l. in central Tibetan Plateau (Western Tanggula Shan, China) provides one of the first multi-millennium-long environmental archives (spanning the last 7000 years and annually resolved for the last 400 years) obtained from the Tibetan Plateau region. The Puruogangri's area is climatologically of particular interest because of its location at the boundary between the monsoon (wet) and the westerly (dry) dominated atmospheric circulation. The major objective of this study is to determine the concentration of trace and ultra-trace elements in the Puruogangri ice core between 1600 and 2000 AD in order to characterize the atmospheric aerosols entrapped in the ice. Particular attention is given to assess the amount of trace elements originating from anthropogenic sources during both the pre-industrial and industrial periods. The distinction between the anthropogenic contribution and the crustal background may rely on the precise decoupling of the dry and wet seasons signals, the former being largely influenced by dust contribution.

  5. The Efficacy of Adapted MBCT on Core Symptoms and Executive Functioning in Adults With ADHD: A Preliminary Randomized Controlled Trial.

    Science.gov (United States)

    Hepark, Sevket; Janssen, Lotte; de Vries, Alicia; Schoenberg, Poppy L A; Donders, Rogier; Kan, Cornelis C; Speckens, Anne E M

    2015-11-20

    The aim of this study was to examine the effectiveness of mindfulness as a treatment for adults diagnosed with ADHD. A 12-week-adapted mindfulness-based cognitive therapy (MBCT) program is compared with a waiting list (WL) group. Adults with ADHD were randomly allocated to MBCT (n = 55) or waitlist (n = 48). Outcome measures included investigator-rated ADHD symptoms (primary), self-reported ADHD symptoms, executive functioning, depressive and anxiety symptoms, patient functioning, and mindfulness skills. MBCT resulted in a significant reduction of ADHD symptoms, both investigator-rated and self-reported, based on per-protocol and intention-to-treat analyses. Significant improvements in executive functioning and mindfulness skills were found. Additional analyses suggested that the efficacy of MBCT in reducing ADHD symptoms and improving executive functioning is partially mediated by an increase in the mindfulness skill "Act With Awareness." No improvements were observed for depressive and anxiety symptoms, and patient functioning. This study provides preliminary support for the effectiveness of MBCT for adults with ADHD. © The Author(s) 2015.

  6. Preliminary Thermo-hydraulic Core Design Analysis of Korea Advanced Nuclear Thermal Engine Rocket for Space Application

    Energy Technology Data Exchange (ETDEWEB)

    Nam, Seung Hyun; Lee, Jeong Ik; Chang, Soon Heung [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of)

    2014-05-15

    {sub th} power and electricity generation with 100 kW{sub th} idle power. Consequently, KANUTER has the characteristics of a compact and lightweight system, excellent propellant efficiency, bimodal capability, and mission versatility as indicated in the reference design parameters. This thermo-hydraulic design analysis was carried out to estimate the optimum FWT of the unique SLHC fuel design in the core and thereby the maximum rocket performance. The FWT affects the mechanical strength of the SLHC fuel assembly as well as the thermo-hydraulic capability mainly depending on the heat transfer area of fuel. The thicker fuel wafer is mechanically strong with low pressure drop, while the thinner fuel wafer is thermally robust with less mechanical strength and higher shear stress in the core.

  7. A core outcome set for localised prostate cancer effectiveness trials: protocol for a systematic review of the literature and stakeholder involvement through interviews and a Delphi survey.

    Science.gov (United States)

    MacLennan, Steven; Bekema, Hendrika J; Williamson, Paula R; Campbell, Marion K; Stewart, Fiona; MacLennan, Sara J; N'Dow, James M O; Lam, Thomas B L

    2015-03-04

    Prostate cancer is a growing health problem worldwide. The management of localised prostate cancer is controversial. It is unclear which of several surgical, radiotherapeutic, ablative, and surveillance treatments is the most effective. All have cost, process and recovery, and morbidity implications which add to treatment decision-making complexity for patients and healthcare professionals. Evidence from randomised controlled trials (RCTs) is not optimal because of uncertainty as to what constitutes important outcomes. Another issue hampering evidence synthesis is heterogeneity of outcome definition, measurement, and reporting. This project aims to determine which outcomes are the most important to patients and healthcare professionals, and use these findings to recommend a standardised core outcome set for comparative effectiveness trials of treatments for localised prostate cancer, to optimise decision-making. The range of potentially important outcomes and measures will be identified through systematic reviews of the literature and semi-structured interviews with patients. A consultation exercise involving representatives from two key stakeholder groups (patients and healthcare professionals) will ratify the list of outcomes to be entered into a three round Delphi study. The Delphi process will refine and prioritise the list of identified outcomes. A methodological substudy (nested RCT design) will also be undertaken. Participants will be randomised after round one of the Delphi study to one of three feedback groups, based on different feedback strategies, in order to explore the potential impact of feedback strategies on participant responses. This may assist the design of a future core outcome set and Delphi studies. Following the Delphi study, a final consensus meeting attended by representatives from both stakeholder groups will determine the final recommended core outcome set. This study will inform clinical practice and future trials of interventions of

  8. A transversal multicenter study assessing functioning, disability and environmental factors with the comprehensive ICF core set for low back pain in Brazil.

    Science.gov (United States)

    Riberto, M; Chiappetta, L M; Lopes, K A; Chiappetta, L R

    2014-04-01

    Low back pain is a leading cause of disability in Brazil. The multiple aspects of disability in these patients require comprehensive tools for their assessment. The International Classification of Functioning, Disability, and Health (ICF) core set for low back pain is designed to comprehensively describe the experience of such patients with their functioning. This study aimed to describe functioning and contextual factors and to empirically validate the ICF core set for low back pain. Cross sectional study. Three outpatient clinics in Manaus, Maceio and São Paulo, Brazil. Population. 135 low back pain outpatients under rehabilitation. Data concerning diagnosis, personal features, and the 78 ICF core set categories for low back pain were collected from clinical charts, physical examinations, tests, and interviews with patients from rehabilitation services in three parts of Brazil. 7.7% of the categories (6 body functions and 10 activity and participation) were affected in less than 20% of the sample, and were thus considered not validated. Pain and other sensations related to the musculoskeletal system were the body most frequently impaired functions. Mobility and domestic life were the chapters of activity and limitation most often described as limited. All environmental factors were qualified as either facilitators or barriers and acted as modulators of disability. The comprehensive ICF core sets for low back pain can be used to describe the living experience of such individuals, although efforts to make it operational and enhance the reproducibility of the results are needed to warrant its reliable routine use. This study highlights the importance of a complete assessment of chronic low back pain and demonstrate the need for multidisciplinary approach.

  9. Mobile Landing Platform with Core Capability Set (MLP w/CCS): Combined Initial Operational Test and Evaluation and Live Fire Test and Evaluation Report

    Science.gov (United States)

    2015-07-01

    SUBTITLE Mobile Landing Platform with Core Capability Set (MLP w/CCS) Combined Initial Operational Test and Evaluation ( IOT &E) and Live Fire Test and...based on data from a series of integrated test events, a dedicated end-to-end Initial Operational Test and Evaluation ( IOT &E), and two Marine Corps...Internally Transportable Vehicles (ITVs).   ii the LMSR to anchor within a few miles of the shore. Using MLP (CCS), the equipment is transported ashore

  10. Can the ICF osteoarthritis core set represent a future clinical tool in measuring functioning in persons with osteoarthritis undergoing hip and knee joint replacement?

    Science.gov (United States)

    Alviar, Maria Jenelyn; Olver, John; Pallant, Julie F; Brand, Caroline; de Steiger, Richard; Pirpiris, Marinis; Bucknill, Andrew; Khan, Fary

    2012-11-01

    To determine the dimensionality, reliability, model fit, adequacy of the qualifier levels, response patterns across different factors, and targeting of the International Classification of Functioning, Disability and Health (ICF) osteoarthritis core set categories in people with osteoarthritis undergoing hip and knee arthroplasty. The osteoarthritis core set was rated in 316 persons with osteoarthritis who were either in the pre-operative or within one year post-operative stage. Rasch analyses were performed using the RUMM 2030 program. Twelve of the 13 body functions categories and 13 of the 19 activity and participation categories had good model fit. The qualifiers displayed disordered thresholds necessitating rescoring. There was uneven spread of ICF categories across the full range of the patients' scores indicating off--targeting. Subtest analysis of the reduced ICF categories of body functions and activity and participation showed that the two components could be integrated to form one measure. The results suggest that it is possible to measure functioning using a unidimensional construct based on ICF osteoarthritis core set categories of body functions and activity and participation in this population. However, omission of some categories and reduction in qualifier levels are necessary. Further studies are needed to determine whether better targeting is achieved, particularly during the pre-operative and during the sub-acute care period.

  11. Recommendation for measuring clinical outcome in distal radius fractures: a core set of domains for standardized reporting in clinical practice and research.

    Science.gov (United States)

    Goldhahn, Jörg; Beaton, Dorcas; Ladd, Amy; Macdermid, Joy; Hoang-Kim, Amy

    2014-02-01

    Lack of standardization of outcome measurement has hampered an evidence-based approach to clinical practice and research. We adopted a process of reviewing evidence on current use of measures and appropriate theoretical frameworks for health and disability to inform a consensus process that was focused on deriving the minimal set of core domains in distal radius fracture. We agreed on the following seven core recommendations: (1) pain and function were regarded as the primary domains, (2) very brief measures were needed for routine administration in clinical practice, (3) these brief measures could be augmented by additional measures that provide more detail or address additional domains for clinical research, (4) measurement of pain should include measures of both intensity and frequency as core attributes, (5) a numeric pain scale, e.g. visual analogue scale or visual numeric scale or the pain subscale of the patient-reported wrist evaluation (PRWE) questionnaires were identified as reliable, valid and feasible measures to measure these concepts, (6) for function, either the Quick Disability of the arm, shoulder and hand questionnaire or PRWE-function subscale was identified as reliable, valid and feasible measures, and (7) a measure of participation and treatment complications should be considered core outcomes for both clinical practice and research. We used a sound methodological approach to form a comprehensive foundation of content for outcomes in the area of distal radius fractures. We recommend the use of symptom and function as separate domains in the ICF core set in clinical research or practice for patients with wrist fracture. Further research is needed to provide more definitive measurement properties of measures across all domains.

  12. Identification of distinct SET/TAF-Ibeta domains required for core histone binding and quantitative characterisation of the interaction.

    Science.gov (United States)

    Karetsou, Zoe; Emmanouilidou, Anastasia; Sanidas, Ioannis; Liokatis, Stamatis; Nikolakaki, Eleni; Politou, Anastasia S; Papamarcaki, Thomais

    2009-04-09

    The assembly of nucleosomes to higher-order chromatin structures is finely tuned by the relative affinities of histones for chaperones and nucleosomal binding sites. The myeloid leukaemia protein SET/TAF-Ibeta belongs to the NAP1 family of histone chaperones and participates in several chromatin-based mechanisms, such as chromatin assembly, nucleosome reorganisation and transcriptional activation. To better understand the histone chaperone function of SET/TAF-Ibeta, we designed several SET/TAF-Ibeta truncations, examined their structural integrity by circular Dichroism and assessed qualitatively and quantitatively the histone binding properties of wild-type protein and mutant forms using GST-pull down experiments and fluorescence spectroscopy-based binding assays. Wild type SET/TAF-Ibeta binds to histones H2B and H3 with Kd values of 2.87 and 0.15 microM, respectively. The preferential binding of SET/TAF-Ibeta to histone H3 is mediated by its central region and the globular part of H3. On the contrary, the acidic C-terminal tail and the amino-terminal dimerisation domain of SET/TAF-Ibeta, as well as the H3 amino-terminal tail, are dispensable for this interaction. This type of analysis allowed us to assess the relative affinities of SET/TAF-Ibeta for different histones and identify the domains of the protein required for effective histone recognition. Our findings are consistent with recent structural studies of SET/TAF-Ibeta and can be valuable to understand the role of SET/TAF-Ibeta in chromatin function.

  13. Identification of distinct SET/TAF-Iβ domains required for core histone binding and quantitative characterisation of the interaction

    Science.gov (United States)

    Karetsou, Zoe; Emmanouilidou, Anastasia; Sanidas, Ioannis; Liokatis, Stamatis; Nikolakaki, Eleni; Politou, Anastasia S; Papamarcaki, Thomais

    2009-01-01

    Background The assembly of nucleosomes to higher-order chromatin structures is finely tuned by the relative affinities of histones for chaperones and nucleosomal binding sites. The myeloid leukaemia protein SET/TAF-Iβ belongs to the NAP1 family of histone chaperones and participates in several chromatin-based mechanisms, such as chromatin assembly, nucleosome reorganisation and transcriptional activation. To better understand the histone chaperone function of SET/TAF-Iβ, we designed several SET/TAF-Iβ truncations, examined their structural integrity by circular Dichroism and assessed qualitatively and quantitatively the histone binding properties of wild-type protein and mutant forms using GST-pull down experiments and fluorescence spectroscopy-based binding assays. Results Wild type SET/TAF-Iβ binds to histones H2B and H3 with Kd values of 2.87 and 0.15 μM, respectively. The preferential binding of SET/TAF-Iβ to histone H3 is mediated by its central region and the globular part of H3. On the contrary, the acidic C-terminal tail and the amino-terminal dimerisation domain of SET/TAF-Iβ, as well as the H3 amino-terminal tail, are dispensable for this interaction. Conclusion This type of analysis allowed us to assess the relative affinities of SET/TAF-Iβ for different histones and identify the domains of the protein required for effective histone recognition. Our findings are consistent with recent structural studies of SET/TAF-Iβ and can be valuable to understand the role of SET/TAF-Iβ in chromatin function. PMID:19358706

  14. Hyper Text Mark-up Language and Dublin Core metadata element set usage in websites of Iranian State Universities’ libraries

    Science.gov (United States)

    Zare-Farashbandi, Firoozeh; Ramezan-Shirazi, Mahtab; Ashrafi-Rizi, Hasan; Nouri, Rasool

    2014-01-01

    Introduction: Recent progress in providing innovative solutions in the organization of electronic resources and research in this area shows a global trend in the use of new strategies such as metadata to facilitate description, place for, organization and retrieval of resources in the web environment. In this context, library metadata standards have a special place; therefore, the purpose of the present study has been a comparative study on the Central Libraries’ Websites of Iran State Universities for Hyper Text Mark-up Language (HTML) and Dublin Core metadata elements usage in 2011. Materials and Methods: The method of this study is applied-descriptive and data collection tool is the check lists created by the researchers. Statistical community includes 98 websites of the Iranian State Universities of the Ministry of Health and Medical Education and Ministry of Science, Research and Technology and method of sampling is the census. Information was collected through observation and direct visits to websites and data analysis was prepared by Microsoft Excel software, 2011. Results: The results of this study indicate that none of the websites use Dublin Core (DC) metadata and that only a few of them have used overlaps elements between HTML meta tags and Dublin Core (DC) elements. The percentage of overlaps of DC elements centralization in the Ministry of Health were 56% for both description and keywords and, in the Ministry of Science, were 45% for the keywords and 39% for the description. But, HTML meta tags have moderate presence in both Ministries, as the most-used elements were keywords and description (56%) and the least-used elements were date and formatter (0%). Conclusion: It was observed that the Ministry of Health and Ministry of Science follows the same path for using Dublin Core standard on their websites in the future. Because Central Library Websites are an example of scientific web pages, special attention in designing them can help the researchers

  15. Hyper Text Mark-up Language and Dublin Core metadata element set usage in websites of Iranian State Universities' libraries.

    Science.gov (United States)

    Zare-Farashbandi, Firoozeh; Ramezan-Shirazi, Mahtab; Ashrafi-Rizi, Hasan; Nouri, Rasool

    2014-01-01

    Recent progress in providing innovative solutions in the organization of electronic resources and research in this area shows a global trend in the use of new strategies such as metadata to facilitate description, place for, organization and retrieval of resources in the web environment. In this context, library metadata standards have a special place; therefore, the purpose of the present study has been a comparative study on the Central Libraries' Websites of Iran State Universities for Hyper Text Mark-up Language (HTML) and Dublin Core metadata elements usage in 2011. The method of this study is applied-descriptive and data collection tool is the check lists created by the researchers. Statistical community includes 98 websites of the Iranian State Universities of the Ministry of Health and Medical Education and Ministry of Science, Research and Technology and method of sampling is the census. Information was collected through observation and direct visits to websites and data analysis was prepared by Microsoft Excel software, 2011. The results of this study indicate that none of the websites use Dublin Core (DC) metadata and that only a few of them have used overlaps elements between HTML meta tags and Dublin Core (DC) elements. The percentage of overlaps of DC elements centralization in the Ministry of Health were 56% for both description and keywords and, in the Ministry of Science, were 45% for the keywords and 39% for the description. But, HTML meta tags have moderate presence in both Ministries, as the most-used elements were keywords and description (56%) and the least-used elements were date and formatter (0%). It was observed that the Ministry of Health and Ministry of Science follows the same path for using Dublin Core standard on their websites in the future. Because Central Library Websites are an example of scientific web pages, special attention in designing them can help the researchers to achieve faster and more accurate information resources

  16. Core domain and outcome measurement sets for shoulder pain trials are needed: Systematic review of physical therapy trials

    NARCIS (Netherlands)

    M.J. Page (Matthew J.); J.E. McKenzie (Joanne E.); S.E. Green (Sally E.); D.E. Beaton (Dorcas E.); N.B. Jain (Nitin B.); M. Lenza (Mario); A.P. Verhagen (Arianne); S. Surace (Stephen); J. Deitch (Jessica); R. Buchbinder (Rachelle)

    2015-01-01

    textabstractObjectives To explore the outcome domains and measurement instruments reported in published randomized controlled trials of physical therapy interventions for shoulder pain (rotator cuff disease, adhesive capsulitis, or nonspecific shoulder pain). Study Design and Setting We included

  17. Crystallization and preliminary X-ray crystallographic analysis of the GluR0 ligand-binding core from Nostoc punctiforme

    International Nuclear Information System (INIS)

    Lee, Jun Hyuck; Park, Soo Jeong; Rho, Seong-Hwan; Im, Young Jun; Kim, Mun-Kyoung; Kang, Gil Bu; Eom, Soo Hyun

    2005-01-01

    The GluR0 ligand-binding core from N. punctiforme was expressed, purified and crystallized in the presence of l-glutamate. A diffraction data set was collected to a resolution of 2.1 Å. GluR0 from Nostoc punctiforme (NpGluR0) is a bacterial homologue of the ionotropic glutamate receptor. The ligand-binding core of NpGluR0 was crystallized at 294 K using the hanging-drop vapour-diffusion method. The l-glutamate-complexed crystal belongs to space group C222 1 , with unit-cell parameters a = 78.0, b = 145.1, c = 132.1 Å. The crystals contain three subunits in the asymmetric unit, with a V M value of 2.49 Å 3 Da −1 . The diffraction limit of the l-glutamate complex data set was 2.1 Å using synchrotron X-ray radiation at beamline BL-4A of the Pohang Accelerator Laboratory (Pohang, Korea)

  18. Crystallization and preliminary X-ray crystallographic analysis of the GluR0 ligand-binding core from Nostoc punctiforme

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jun Hyuck; Park, Soo Jeong; Rho, Seong-Hwan; Im, Young Jun; Kim, Mun-Kyoung; Kang, Gil Bu; Eom, Soo Hyun, E-mail: eom@gist.ac.kr [Department of Life Science, Gwangju Institute of Science and Technology, Gwangju 500-712 (Korea, Republic of)

    2005-11-01

    The GluR0 ligand-binding core from N. punctiforme was expressed, purified and crystallized in the presence of l-glutamate. A diffraction data set was collected to a resolution of 2.1 Å. GluR0 from Nostoc punctiforme (NpGluR0) is a bacterial homologue of the ionotropic glutamate receptor. The ligand-binding core of NpGluR0 was crystallized at 294 K using the hanging-drop vapour-diffusion method. The l-glutamate-complexed crystal belongs to space group C222{sub 1}, with unit-cell parameters a = 78.0, b = 145.1, c = 132.1 Å. The crystals contain three subunits in the asymmetric unit, with a V{sub M} value of 2.49 Å{sup 3} Da{sup −1}. The diffraction limit of the l-glutamate complex data set was 2.1 Å using synchrotron X-ray radiation at beamline BL-4A of the Pohang Accelerator Laboratory (Pohang, Korea)

  19. Independent evolution of the core and accessory gene sets in the genus Neisseria: insights gained from the genome of Neisseria lactamica isolate 020-06

    Directory of Open Access Journals (Sweden)

    White Brian

    2010-11-01

    Full Text Available Abstract Background The genus Neisseria contains two important yet very different pathogens, N. meningitidis and N. gonorrhoeae, in addition to non-pathogenic species, of which N. lactamica is the best characterized. Genomic comparisons of these three bacteria will provide insights into the mechanisms and evolution of pathogenesis in this group of organisms, which are applicable to understanding these processes more generally. Results Non-pathogenic N. lactamica exhibits very similar population structure and levels of diversity to the meningococcus, whilst gonococci are essentially recent descendents of a single clone. All three species share a common core gene set estimated to comprise around 1190 CDSs, corresponding to about 60% of the genome. However, some of the nucleotide sequence diversity within this core genome is particular to each group, indicating that cross-species recombination is rare in this shared core gene set. Other than the meningococcal cps region, which encodes the polysaccharide capsule, relatively few members of the large accessory gene pool are exclusive to one species group, and cross-species recombination within this accessory genome is frequent. Conclusion The three Neisseria species groups represent coherent biological and genetic groupings which appear to be maintained by low rates of inter-species horizontal genetic exchange within the core genome. There is extensive evidence for exchange among positively selected genes and the accessory genome and some evidence of hitch-hiking of housekeeping genes with other loci. It is not possible to define a 'pathogenome' for this group of organisms and the disease causing phenotypes are therefore likely to be complex, polygenic, and different among the various disease-associated phenotypes observed.

  20. Development of a core set of quality indicators for paediatric primary care practices in Europe, COSI-PPC-EU.

    Science.gov (United States)

    Ewald, Dominik A; Huss, Gottfried; Auras, Silke; Caceres, Juan Ruiz-Canela; Hadjipanayis, Adamos; Geraedts, Max

    2018-06-01

    Paediatric ambulatory healthcare systems in Europe are, because of historical reasons, diverse and show strikingly different outcomes. All across Europe, the benchmarking of structures, processes and outcomes could reveal opportunities for improving Paediatric Primary Care (PPC). The aim of this study was to develop a set of Quality Indicators (QIs) to assess and monitor PPC in Europe. In a three-step process, we used the available external evidence and European expert consensus in a modified RAND/UCLA Appropriateness Method (RAM) to develop an indicator set. (1) A broad literature and online research of published QI and guidelines yielded an inventory of 1516 QI. (2) A collaborative panel of paediatric senior experts from the European Academy of Paediatrics (EAP) and the European Confederation of Primary Care Paediatricians (ECPCP) from 15 European countries participated in a first consensus process to reduce the initial indicator inventory by eliminating not PPC-focused indicators and duplicates. (3) In a second consensus process, the panel rated the QI regarding validity and feasibility. The final QI set "COSI-PPC-EU" consists of 42 indicators in five categories of PPC: (A) health promotion/prevention/screening (13 QI), (B) acute care (9 QI), (C) chronic care (8 QI), (D) practice management (3 QI) and (E) patient safety (9 QI). COSI-PPC-EU represents a consented set of a limited number of valid quality indicators for the application in paediatric primary care in different healthcare systems throughout Europe. What is Known: • Paediatric ambulatory healthcare systems in Europe are diverse and show strikingly different outcomes. • There are known gaps in quality performance measures of paediatric primary care in Europe. Pre-existing sets of quality indicators are predominantly limited to national populations, specific diseases and hospital care. What is New: • A set of 42 quality indicators for primary paediatric care in Europe was developed in a multi

  1. Towards a spectroscopically accurate set of potentials for heavy hydride laser cooling candidates: Effective core potential calculations of BaH

    Energy Technology Data Exchange (ETDEWEB)

    Moore, Keith; McLaughlin, Brendan M.; Lane, Ian C., E-mail: i.lane@qub.ac.uk [School of Chemistry and Chemical Engineering, Queen’s University Belfast, Stranmillis Road, Belfast BT9 5AG (United Kingdom)

    2016-04-14

    BaH (and its isotopomers) is an attractive molecular candidate for laser cooling to ultracold temperatures and a potential precursor for the production of ultracold gases of hydrogen and deuterium. The theoretical challenge is to simulate the laser cooling cycle as reliably as possible and this paper addresses the generation of a highly accurate ab initio {sup 2}Σ{sup +} potential for such studies. The performance of various basis sets within the multi-reference configuration-interaction (MRCI) approximation with the Davidson correction is tested and taken to the Complete Basis Set (CBS) limit. It is shown that the calculated molecular constants using a 46 electron effective core-potential and even-tempered augmented polarized core-valence basis sets (aug-pCVnZ-PP, n = 4 and 5) but only including three active electrons in the MRCI calculation are in excellent agreement with the available experimental values. The predicted dissociation energy D{sub e} for the X{sup 2}Σ{sup +} state (extrapolated to the CBS limit) is 16 895.12 cm{sup −1} (2.094 eV), which agrees within 0.1% of a revised experimental value of <16 910.6 cm{sup −1}, while the calculated r{sub e} is within 0.03 pm of the experimental result.

  2. High-resolution C and O stable isotope geochemistry of the early Aptian OAE1a at Cau (Prebetic Zone, Spain): Preliminary results from sediment core.

    Science.gov (United States)

    Alejandro Ruiz-Ortiz, Pedro; Aguado, Roque; Castro, José Manuel; Gallego, David; de Gea, Ginés Alfonso; Jarvis, Ian; Molina, José Miguel; Nieto, Luis Miguel; Pancost, Richard; Quijano, María Luisa; Reolid, Matías; Rodriguez, Rafael; Skelton, Peter; Weisser, Helmut

    2017-04-01

    correlation with previously defined and worldwide recognized C-isotope segments of Menegatti et al. [2]. Along with the C-isotope stratigraphy, correlated with previous biostratigraphic and geochemical data from outcrop studies, profiles of magnetic susceptibility data (measured from the core in the laboratory) and geophysical log profiles measured down-hole, are presented. Preliminary sedimentological analyses of the core have been completed, with a focus on lithology and sedimentary structures, including ichnofacies of bioturbated levels. The facies association is dominated by dark marlstones, displaying a cyclic vertical organization. These results confirm and refine previous data, and will be the base for ongoing analytical studies at a high-resolution scale, covering geochemical, biostratigraphic, sedimentological, ichnological and cyclostratigraphic analyses of the core. Acknowledgements: This work is a contribution of the research project CGL2014-55274-P (Gov. of Spain) and Research Group RNM-200 (PAIDI-JA). [1] Robinson et al. (2017). Sedimentology, 64, 1-15 [2] Menegatti et al. (1998). Paleoceanography 13, 530-545. [3] Gea et al. (2003) Palaeo3. 200, 207-219. [4] Quijano et al. (2012). Palaeo3. 365-366, 276-293. [5] Naafs et al. (2016). Nat. Geosc. 9 (2), 135-139. [6] Ruiz-Ortiz et al. (2016). Sci. Dril. 21, 41-46.

  3. Feasibility of using training cases from International Spinal Cord Injury Core Data Set for testing of International Standards for Neurological Classification of Spinal Cord Injury items

    DEFF Research Database (Denmark)

    Liu, N; Hu, Z W; Zhou, M W

    2014-01-01

    STUDY DESIGN: Descriptive comparison analysis. OBJECTIVE: To evaluate whether five training cases of International Spinal Cord Injury Core Data Set (ISCICDS) are appropriate for testing the facts within the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI...... include information about zone of partial preservation, sensory score or motor score. CONCLUSION: Majority of the facts related to SL, ML and AIS are included in the five training cases of ISCICDS. Thus, using these training cases, it is feasible to test the above facts within the ISNCSCI. It is suggested...

  4. Approximate Cores of a General Class of Economies. Part II. Set-Up Costs and Firm Formation in Coalition Production Economies,

    Science.gov (United States)

    1982-02-01

    r AAI1Z 608 YALE UNIV NEW HAVEN CT C OWLES FOUNDATION FOR RESEARC --ETC F/G 513 APPROXIMATE CORES 6F A GENERAL CLASS OF ECONOMIES. PART It. SET--ETC(U...theoretic models of the economy in strategic form are institutional. Markets and firms and even money are assumed to exist. Cooperative game theory can be...groups. Alternatively we can define firms and firms- in-being, specify the manner of trade in the markets , define what is meant by entry and exit and

  5. Preliminary findings of an investigation into the relationship between national culture and EQ-5D value sets.

    Science.gov (United States)

    Bailey, Henry; Kind, Paul

    2010-10-01

    Despite the growing importance of the EQ-5D descriptive system as a basis for the valuation of QALYs in cost-utility analysis, for most countries, there are no EQ-5D value sets. Researchers and policy makers wishing to use the EQ-5D descriptive system in a country for which there is no value set are advised to use one from a nearby or 'similar' population. Factors other than geographic proximity can affect the relative values of EQ-5D states. This study explores the links between national culture and EQ-5D value sets. Rank correlation analysis is used to explore relationships between the relative values of a set of EQ-5D states and dimensions of national culture. The latter are taken from Hofstede's framework which operationalizes national culture in five dimensions. For the data currently available (countries for which EQ-5D value sets and scores on dimensions of culture both exist), moderate and strong correlations were found between the culture dimension of power distance and individualism and the EQ-5D dimensions of pain/discomfort and anxiety/depression. Moderate correlations were also observed between the cultural dimension of masculinity and the EQ-5D dimensions of self care, usual activities and pain/discomfort. Uncertainty avoidance correlates with the EQ-5D dimension of anxiety/depression. The correlation patterns observed are generally consistent with a priori expectations based on the nature of the dimensions of culture and the EQ-5D model. This analysis demonstrates the potential of national culture in providing insight into the drivers of the relative values of EQ-5D dimensions for different countries and in informing decisions about which EQ-5D value sets to use in situations where one does not exist.

  6. A Preliminary Investigation of a Specialized Music Therapy Model for Children with Disabilities Delivered in a Classroom Setting

    Directory of Open Access Journals (Sweden)

    Jenna Mendelson

    2016-01-01

    Full Text Available Music therapy is gaining popularity as an intervention strategy for children with developmental disabilities, including autism spectrum disorder (ASD. This study was a pilot investigation of a classroom-based music-based intervention, Voices Together®, for improving communication skills in children with ASD and children with intellectual disabilities. Four local public elementary school special education classrooms, serving 5 children with a classification of autistic disorder and 32 children with intellectual disability without autism, were randomly selected to receive one of two levels of exposure to Voices Together music therapy: “long-term” (15 weeks beginning in January 2015 (Time 1, n=14 or “short-term” (7 weeks beginning 7 weeks later in February (Time 2, n=17. Using observational ratings, investigators reliably scored participants live in terms of their level of verbal responsiveness to prompts during three songs featured each week of the program. Both groups demonstrated increases in verbal responses over time; however, only the long-term group demonstrated significant within-group increases. Preliminary findings suggest that music therapy delivered in a classroom in 45-minute weekly sessions for 15 weeks can promote improvements in verbal responsiveness among individuals with autism and other developmental disabilities. Findings warrant further investigation into the efficacy of classroom-based music therapy programs.

  7. A Preliminary Investigation of a Specialized Music Therapy Model for Children with Disabilities Delivered in a Classroom Setting.

    Science.gov (United States)

    Mendelson, Jenna; White, Yasmine; Hans, Laura; Adebari, Richard; Schmid, Lorrie; Riggsbee, Jan; Goldsmith, Ali; Ozler, Burcu; Buehne, Kristen; Jones, Sarah; Shapleton, Jennifer; Dawson, Geraldine

    2016-01-01

    Music therapy is gaining popularity as an intervention strategy for children with developmental disabilities, including autism spectrum disorder (ASD). This study was a pilot investigation of a classroom-based music-based intervention, Voices Together® , for improving communication skills in children with ASD and children with intellectual disabilities. Four local public elementary school special education classrooms, serving 5 children with a classification of autistic disorder and 32 children with intellectual disability without autism, were randomly selected to receive one of two levels of exposure to Voices Together music therapy: "long-term" (15 weeks beginning in January 2015 (Time 1), n = 14) or "short-term" (7 weeks beginning 7 weeks later in February (Time 2), n = 17). Using observational ratings, investigators reliably scored participants live in terms of their level of verbal responsiveness to prompts during three songs featured each week of the program. Both groups demonstrated increases in verbal responses over time; however, only the long-term group demonstrated significant within-group increases. Preliminary findings suggest that music therapy delivered in a classroom in 45-minute weekly sessions for 15 weeks can promote improvements in verbal responsiveness among individuals with autism and other developmental disabilities. Findings warrant further investigation into the efficacy of classroom-based music therapy programs.

  8. Low COST surgery setting for one-operational port laparoscopic hysterectomy surgery with ordinary laparoscopic instruments: preliminary results.

    Science.gov (United States)

    Limberger, Leo Francisco; Campos, Luciana Silveira; da Alves, Nilton Jacinto Rosa; Pedrini, Daniel Siqueira; de Limberger, Andiara Souza

    2013-10-02

    Hysterectomy dates back to 120BC and is the second most commonly performed gynecological surgery in the world. Cosmetic demands and the necessity of rapid return to work have contributed to the minimally invasive laparoscopic approach for hysterectomy. The majority of reports describe the use of three or four incisions to perform the surgery (two or three for manipulation and one for optics). This work describes our experience with using only two ports for 11 patients who underwent video-laparoscopic hysterectomy surgery. One port was used for the optical system, and the second was used for manipulation. Early and late surgery complications, as well as the time to return to work and daily activities, were assessed. The mean age of the patients was 41.4 years old (range 16 to 52 years) and the mean uterine weight was 133.54 g, ranging from 35 g and 291 g. The operative time ranged from 30 to 60 minutes (average 46.4 minutes) and the hospital stay ranged between 24 and 48 hrs. No intraoperative complications occurred, and no early or late postoperative complications were recorded. Patients reported minimal pain during the first 24-48 hrs in the hospital. Patients returned to their daily activities within seven days after surgery. Clinical care follow-up continued until the 40th postoperative day. The laparoscopic hysterectomy technique with a single port for manipulation is a feasible procedure when the uterine weight is not greater than 400 mg with little postoperative pain. The patients had an early return-to-work and daily activities and a better cosmetic outcome. These preliminary data led us to make the one-operative port laparoscopic hysterectomy the procedure of choice for patients with a low uterine weight.

  9. Preliminary adaptation into Portuguese of a standardised picture set for the use in research and neuropsychological assessment

    Directory of Open Access Journals (Sweden)

    POMPÉIA SABINE

    1998-01-01

    Full Text Available Pictorial stimuli and words have been widely used to evaluate mnemonic processes in clinical settings, neuropsychological investigations, as well as in studies on the mechanisms underlying the phenomena of memory. However, there seem to be few studies of standardisation of pictures for research in this field. The present paper aimed at adapting the use of a set of pictures standardised for English speaking subjects for Portuguese speakers. Name agreement of 150 pictures was assessed in 100 high-school students. Ninety pictures were found to present the same name for over 90 subjects. Results yield data that may help create more controlled tests for the study of memory for pictorial stimuli in Brazil.

  10. Preliminary map of peak horizontal ground acceleration for the Hanshin-Awaji earthquake of January 17, 1995, Japan - Description of Mapped Data Sets

    Science.gov (United States)

    Borcherdt, R.D.; Mark, R.K.

    1995-01-01

    The Hanshin-Awaji earthquake (also known as the Hyogo-ken Nanbu and the Great Hanshin earthquake) provided an unprecedented set of measurements of strong ground shaking. The measurements constitute the most comprehensive set of strong- motion recordings yet obtained for sites underlain by soft soil deposits of Holocene age within a few kilometers of the crustal rupture zone. The recordings, obtained on or near many important structures, provide an important new empirical data set for evaluating input ground motion levels and site amplification factors for codes and site-specific design procedures world wide. This report describes the data used to prepare a preliminary map summarizing the strong motion data in relation to seismicity and underlying geology (Wentworth, Borcherdt, and Mark., 1995; Figure 1, hereafter referred to as Figure 1/I). The map shows station locations, peak acceleration values, and generalized acceleration contours superimposed on pertinent seismicity and the geologic map of Japan. The map (Figure 1/I) indicates a zone of high acceleration with ground motions throughout the zone greater than 400 gal and locally greater than 800 gal. This zone encompasses the area of most intense damage mapped as JMA intensity level 7, which extends through Kobe City. The zone of most intense damage is parallel, but displaced slightly from the surface projection of the crustal rupture zone implied by aftershock locations. The zone is underlain by soft-soil deposits of Holocene age.

  11. Internet-enabled pulmonary rehabilitation and diabetes education in group settings at home: a preliminary study of patient acceptability.

    Science.gov (United States)

    Burkow, Tatjana M; Vognild, Lars K; Østengen, Geir; Johnsen, Elin; Risberg, Marijke Jongsma; Bratvold, Astrid; Hagen, Tord; Brattvoll, Morten; Krogstad, Trine; Hjalmarsen, Audhild

    2013-03-05

    The prevalence of major chronic illnesses, such as chronic obstructive pulmonary disease (COPD) and diabetes, is increasing. Pulmonary rehabilitation and diabetes self-management education are important in the management of COPD and diabetes respectively. However, not everyone can participate in the programmes offered at a hospital or other central locations, for reasons such as travel and transport. Internet-enabled home-based programmes have the potential to overcome these barriers.This study aims to assess patient acceptability of the delivery form and components of Internet-enabled programmes based on home groups for comprehensive pulmonary rehabilitation and for diabetes self-management education. We have developed Internet-enabled home programmes for comprehensive pulmonary rehabilitation and for diabetes self-management education that include group education, group exercising (COPD only), individual consultations, educational videos and a digital health diary. Our prototype technology platform makes use of each user's own TV at home, connected to a computer, and a remote control. We conducted a six-week home trial with 10 participants: one group with COPD and one with diabetes. The participants were interviewed using semi-structured interviews. Both home-based programmes were well accepted by the participants. The group setting at home made it possible to share experiences and to learn from questions raised by others, as in conventional group education. In the sessions, interaction and discussion worked well, despite the structure needed for turn taking. The thematic educational videos were well accepted although they were up to 40 minutes long and their quality was below TV broadcasting standards. Taking part in group exercising at home under the guidance of a physiotherapist was also well accepted by the participants. Participants in the COPD group appreciated the social aspect of group education sessions and of exercising together, each in their own home

  12. Does cortisol influence core executive functions? A meta-analysis of acute cortisol administration effects on working memory, inhibition, and set-shifting.

    Science.gov (United States)

    Shields, Grant S; Bonner, Joseph C; Moons, Wesley G

    2015-08-01

    The hormone cortisol is often believed to play a pivotal role in the effects of stress on human cognition. This meta-analysis is an attempt to determine the effects of acute cortisol administration on core executive functions. Drawing on both rodent and stress literatures, we hypothesized that acute cortisol administration would impair working memory and set-shifting but enhance inhibition. Additionally, because cortisol is thought to exert different nongenomic (rapid) and genomic (slow) effects, we further hypothesized that the effects of cortisol would differ as a function of the delay between cortisol administration and cognitive testing. Although the overall analyses were nonsignificant, after separating the rapid, nongenomic effects of cortisol from the slower, genomic effects of cortisol, the rapid effects of cortisol enhanced response inhibition, g+ = 0.113, p=.016, but impaired working memory, g+ = -0.315, p=.008, although these effects reversed over time. Contrary to our hypotheses, there was no effect of cortisol administration on set-shifting. Thus, although we did not find support for the idea that increases in cortisol influence set-shifting, we found that acute increases in cortisol exert differential effects on working memory and inhibition over time. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. Therapeutic strategies evaluated by the European Society of Cutaneous Lupus Erythematosus (EUSCLE) Core Set Questionnaire in more than 1000 patients with cutaneous lupus erythematosus

    DEFF Research Database (Denmark)

    Sigges, Johanna; Biazar, Cyrus; Landmann, Aysche

    2013-01-01

    The aim of this prospective, cross-sectional, multicentre study performed by the European Society of Cutaneous Lupus Erythematosus (EUSCLE) was to investigate different therapeutic strategies and their efficacies in cutaneous lupus erythematosus (CLE) throughout Europe. Using the EUSCLE Core Set...... Questionnaire, topical and systemic treatment options were analysed in a total of 1002 patients (768 females and 234 males) with different CLE subtypes. The data were correlated with the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) and the criteria of the American College...... of Rheumatology (ACR) for the classification of systemic lupus erythematosus. Sunscreens were applied by 84.0% of the study cohort and showed a high efficacy in preventing skin lesions in all disease subtypes, correlating with a lower CLASI activity score. Topical steroids were used in 81.5% of the patients...

  14. Canadian valuation of EQ-5D health states: preliminary value set and considerations for future valuation studies.

    Directory of Open Access Journals (Sweden)

    Nick Bansback

    Full Text Available The EQ-5D is a preference based instrument which provides a description of a respondent's health status, and an empirically derived value for that health state often from a representative sample of the general population. It is commonly used to derive Quality Adjusted Life Year calculations (QALY in economic evaluations. However, values for health states have been found to differ between countries. The objective of this study was to develop a set of values for the EQ-5D health states for use in Canada.Values for 48 different EQ-5D health states were elicited using the Time Trade Off (TTO via a web survey in English. A random effect model was fitted to the data to estimate values for all 243 health states of the EQ-5D. Various model specifications were explored. Comparisons with EQ-5D values from the UK and US were made. Sensitivity analysis explored different transformations of values worse than dead, and exclusion criteria of subjects.The final model was estimated from the values of 1145 subjects with socio-demographics broadly representative of Canadian general population with the exception of Quebec. This yielded a good fit with observed TTO values, with an overall R2 of 0.403 and a mean absolute error of 0.044.A preference-weight algorithm for Canadian studies that include the EQ-5D is developed. The primary limitations regarded the representativeness of the final sample, given the language used (English only, the method of recruitment, and the difficulty in the task. Insights into potential issues for conducting valuation studies in countries as large and diverse as Canada are gained.

  15. A Workplace Mindfulness Intervention May Be Associated With Improved Psychological Well-Being and Productivity. A Preliminary Field Study in a Company Setting

    Science.gov (United States)

    Kersemaekers, Wendy; Rupprecht, Silke; Wittmann, Marc; Tamdjidi, Chris; Falke, Pia; Donders, Rogier; Speckens, Anne; Kohls, Niko

    2018-01-01

    Background: Mindfulness trainings are increasingly offered in workplace environments in order to improve health and productivity. Whilst promising, there is limited research on the effectiveness of mindfulness interventions in workplace settings. Objective: To examine the feasibility and effectiveness of a Workplace Mindfulness Training (WMT) in terms of burnout, psychological well-being, organizational and team climate, and performance. Methods: This is a preliminary field study in four companies. Self-report questionnaires were administered up to a month before, at start of, and right at the end of the WMT, resulting in a pre-intervention and an intervention period. There was no separate control group. A total of 425 participants completed the surveys on the different time points. Linear mixed model analyses were used to analyze the data. Results: When comparing the intervention period with the pre-intervention period, significantly greater improvements were found in measures of burnout (mean difference = 0.3, p mindfulness [mean difference = 1.0 for the Freiburg Mindfulness Inventory (FMI) and 0.8 for the Mindfulness Attention Awareness Scale (MAAS), both p mindfulness (d > 0.8), moderate for well-being, burnout and perceived stress (d = 0.5–0.8), and ranged from low to moderate for organizational and team climate and personal performance (d = 0.2–0.8). Conclusion: These preliminary data suggest that compared to the pre-intervention period, the intervention period was associated with greater reductions in burnout and perceived stress, improvements in mindfulness, well-being, and increases in team and organizational climate and personal performance. Due to design limitations, no conclusions can be drawn on the extent to which the WMT or non-specific factors such as time have contributed to the findings. Further studies, preferably using randomized controlled designs with longer follow up periods are needed to evaluate whether the associations found can be

  16. The 'Outcome Reporting in Brief Intervention Trials: Alcohol' (ORBITAL) framework: protocol to determine a core outcome set for efficacy and effectiveness trials of alcohol screening and brief intervention.

    Science.gov (United States)

    Shorter, G W; Heather, N; Bray, Jeremy W; Giles, E L; Holloway, A; Barbosa, C; Berman, A H; O'Donnell, A J; Clarke, M; Stockdale, K J; Newbury-Birch, D

    2017-12-22

    The evidence base to assess the efficacy and effectiveness of alcohol brief interventions (ABI) is weakened by variation in the outcomes measured and by inconsistent reporting. The 'Outcome Reporting in Brief Intervention Trials: Alcohol' (ORBITAL) project aims to develop a core outcome set (COS) and reporting guidance for its use in future trials of ABI in a range of settings. An international Special Interest Group was convened through INEBRIA (International Network on Brief Interventions for Alcohol and Other Drugs) to inform the development of a COS for trials of ABI. ORBITAL will incorporate a systematic review to map outcomes used in efficacy and effectiveness trials of ABI and their measurement properties, using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) criteria. This will support a multi-round Delphi study to prioritise outcomes. Delphi panellists will be drawn from a range of settings and stakeholder groups, and the Delphi study will also be used to determine if a single COS is relevant for all settings. A consensus meeting with key stakeholder representation will determine the final COS and associated guidance for its use in trials of ABI. ORBITAL will develop a COS for alcohol screening and brief intervention trials, with outcomes stratified into domains and guidance on outcome measurement instruments. The standardisation of ABI outcomes and their measurement will support the ongoing development of ABI studies and a systematic synthesis of emerging research findings. We will track the extent to which the COS delivers on this promise through an exploration of the use of the guidance in the decade following COS publication.

  17. Do Patient-Reported Outcome Measures describe functioning in patients with low back pain, using the Brief International Classification of Functioning, Disability and Health Core Set as a reference?

    DEFF Research Database (Denmark)

    Ibsen, Charlotte; Schiøttz-Christensen, Berit; Melchiorsen, Hanne

    2016-01-01

    OBJECTIVE: To link the items in the Patient-Reported Outcome Measures (PROMs): Roland Morris Disability Questionnaire, Short Form 36 (SF-36) and pain scores, to the Brief International Classification of Functioning, Disability and Health (ICF) Core Set for low back pain, and to examine the extent...... Set (34%). A weak correlation was found between the patients' responses and the clinician's assessment. CONCLUSION: The selected PROMs do not cover the prototypical spectrum of problems encountered in patients with low back pain as defined by the Brief ICF Core Set. The clinical assessment of patients...

  18. Analysis of Genetic Diversity and Population Structure of Rice Germplasm from North-Eastern Region of India and Development of a Core Germplasm Set

    Science.gov (United States)

    Singh, Amit Kumar; Kumar, Sundeep; Srinivasan, Kalyani; Tyagi, R. K.; Ahmad, Altaf; Singh, N. K.; Singh, Rakesh

    2014-01-01

    The North-Eastern region (NER) of India, comprising of Arunachal Pradesh, Assam, Manipur, Meghalaya, Mizoram, Nagaland and Tripura, is a hot spot for genetic diversity and the most probable origin of rice. North-east rice collections are known to possess various agronomically important traits like biotic and abiotic stress tolerance, unique grain and cooking quality. The genetic diversity and associated population structure of 6,984 rice accessions, originating from NER, were assessed using 36 genome wide unlinked single nucleotide polymorphism (SNP) markers distributed across the 12 rice chromosomes. All of the 36 SNP loci were polymorphic and bi-allelic, contained five types of base substitutions and together produced nine types of alleles. The polymorphic information content (PIC) ranged from 0.004 for Tripura to 0.375 for Manipur and major allele frequency ranged from 0.50 for Assam to 0.99 for Tripura. Heterozygosity ranged from 0.002 in Nagaland to 0.42 in Mizoram and gene diversity ranged from 0.006 in Arunachal Pradesh to 0.50 in Manipur. The genetic relatedness among the rice accessions was evaluated using an unrooted phylogenetic tree analysis, which grouped all accessions into three major clusters. For determining population structure, populations K = 1 to K = 20 were tested and population K = 3 was present in all the states, with the exception of Meghalaya and Manipur where, K = 5 and K = 4 populations were present, respectively. Principal Coordinate Analysis (PCoA) showed that accessions were distributed according to their population structure. AMOVA analysis showed that, maximum diversity was partitioned at the individual accession level (73% for Nagaland, 58% for Arunachal Pradesh and 57% for Tripura). Using POWERCORE software, a core set of 701 accessions was obtained, which accounted for approximately 10% of the total NE India collections, representing 99.9% of the allelic diversity. The rice core set developed will be a

  19. Analysis of genetic diversity and population structure of rice germplasm from north-eastern region of India and development of a core germplasm set.

    Directory of Open Access Journals (Sweden)

    Debjani Roy Choudhury

    Full Text Available The North-Eastern region (NER of India, comprising of Arunachal Pradesh, Assam, Manipur, Meghalaya, Mizoram, Nagaland and Tripura, is a hot spot for genetic diversity and the most probable origin of rice. North-east rice collections are known to possess various agronomically important traits like biotic and abiotic stress tolerance, unique grain and cooking quality. The genetic diversity and associated population structure of 6,984 rice accessions, originating from NER, were assessed using 36 genome wide unlinked single nucleotide polymorphism (SNP markers distributed across the 12 rice chromosomes. All of the 36 SNP loci were polymorphic and bi-allelic, contained five types of base substitutions and together produced nine types of alleles. The polymorphic information content (PIC ranged from 0.004 for Tripura to 0.375 for Manipur and major allele frequency ranged from 0.50 for Assam to 0.99 for Tripura. Heterozygosity ranged from 0.002 in Nagaland to 0.42 in Mizoram and gene diversity ranged from 0.006 in Arunachal Pradesh to 0.50 in Manipur. The genetic relatedness among the rice accessions was evaluated using an unrooted phylogenetic tree analysis, which grouped all accessions into three major clusters. For determining population structure, populations K = 1 to K = 20 were tested and population K = 3 was present in all the states, with the exception of Meghalaya and Manipur where, K = 5 and K = 4 populations were present, respectively. Principal Coordinate Analysis (PCoA showed that accessions were distributed according to their population structure. AMOVA analysis showed that, maximum diversity was partitioned at the individual accession level (73% for Nagaland, 58% for Arunachal Pradesh and 57% for Tripura. Using POWERCORE software, a core set of 701 accessions was obtained, which accounted for approximately 10% of the total NE India collections, representing 99.9% of the allelic diversity. The rice core set developed

  20. Analysis of genetic diversity and population structure of rice germplasm from north-eastern region of India and development of a core germplasm set.

    Science.gov (United States)

    Roy Choudhury, Debjani; Singh, Nivedita; Singh, Amit Kumar; Kumar, Sundeep; Srinivasan, Kalyani; Tyagi, R K; Ahmad, Altaf; Singh, N K; Singh, Rakesh

    2014-01-01

    The North-Eastern region (NER) of India, comprising of Arunachal Pradesh, Assam, Manipur, Meghalaya, Mizoram, Nagaland and Tripura, is a hot spot for genetic diversity and the most probable origin of rice. North-east rice collections are known to possess various agronomically important traits like biotic and abiotic stress tolerance, unique grain and cooking quality. The genetic diversity and associated population structure of 6,984 rice accessions, originating from NER, were assessed using 36 genome wide unlinked single nucleotide polymorphism (SNP) markers distributed across the 12 rice chromosomes. All of the 36 SNP loci were polymorphic and bi-allelic, contained five types of base substitutions and together produced nine types of alleles. The polymorphic information content (PIC) ranged from 0.004 for Tripura to 0.375 for Manipur and major allele frequency ranged from 0.50 for Assam to 0.99 for Tripura. Heterozygosity ranged from 0.002 in Nagaland to 0.42 in Mizoram and gene diversity ranged from 0.006 in Arunachal Pradesh to 0.50 in Manipur. The genetic relatedness among the rice accessions was evaluated using an unrooted phylogenetic tree analysis, which grouped all accessions into three major clusters. For determining population structure, populations K = 1 to K = 20 were tested and population K = 3 was present in all the states, with the exception of Meghalaya and Manipur where, K = 5 and K = 4 populations were present, respectively. Principal Coordinate Analysis (PCoA) showed that accessions were distributed according to their population structure. AMOVA analysis showed that, maximum diversity was partitioned at the individual accession level (73% for Nagaland, 58% for Arunachal Pradesh and 57% for Tripura). Using POWERCORE software, a core set of 701 accessions was obtained, which accounted for approximately 10% of the total NE India collections, representing 99.9% of the allelic diversity. The rice core set developed will be a

  1. Conceptual aspects: analyses law, ethical, human, technical, social factors of development ICT, e-learning and intercultural development in different countries setting out the previous new theoretical model and preliminary findings

    NARCIS (Netherlands)

    Kommers, Petrus A.M.; Smyrnova-Trybulska, Eugenia; Morze, Natalia; Issa, Tomayess; Issa, Theodora

    2015-01-01

    This paper, prepared by an international team of authors focuses on the conceptual aspects: analyses law, ethical, human, technical, social factors of ICT development, e-learning and intercultural development in different countries, setting out the previous and new theoretical model and preliminary

  2. A Workplace Mindfulness Intervention May Be Associated With Improved Psychological Well-Being and Productivity. A Preliminary Field Study in a Company Setting.

    Science.gov (United States)

    Kersemaekers, Wendy; Rupprecht, Silke; Wittmann, Marc; Tamdjidi, Chris; Falke, Pia; Donders, Rogier; Speckens, Anne; Kohls, Niko

    2018-01-01

    Background: Mindfulness trainings are increasingly offered in workplace environments in order to improve health and productivity. Whilst promising, there is limited research on the effectiveness of mindfulness interventions in workplace settings. Objective: To examine the feasibility and effectiveness of a Workplace Mindfulness Training (WMT) in terms of burnout, psychological well-being, organizational and team climate, and performance. Methods: This is a preliminary field study in four companies. Self-report questionnaires were administered up to a month before, at start of, and right at the end of the WMT, resulting in a pre-intervention and an intervention period. There was no separate control group. A total of 425 participants completed the surveys on the different time points. Linear mixed model analyses were used to analyze the data. Results: When comparing the intervention period with the pre-intervention period, significantly greater improvements were found in measures of burnout (mean difference = 0.3, p Inventory (FMI) and 0.8 for the Mindfulness Attention Awareness Scale (MAAS), both p team climate, organizational climate and personal performance were reported during the intervention compared to the pre-intervention period with largest improvements in team cooperation (mean difference = 0.3, p 0.8), moderate for well-being, burnout and perceived stress ( d = 0.5-0.8), and ranged from low to moderate for organizational and team climate and personal performance ( d = 0.2-0.8). Conclusion: These preliminary data suggest that compared to the pre-intervention period, the intervention period was associated with greater reductions in burnout and perceived stress, improvements in mindfulness, well-being, and increases in team and organizational climate and personal performance. Due to design limitations, no conclusions can be drawn on the extent to which the WMT or non-specific factors such as time have contributed to the findings. Further studies, preferably

  3. A Workplace Mindfulness Intervention May Be Associated With Improved Psychological Well-Being and Productivity. A Preliminary Field Study in a Company Setting

    Directory of Open Access Journals (Sweden)

    Wendy Kersemaekers

    2018-02-01

    Full Text Available Background: Mindfulness trainings are increasingly offered in workplace environments in order to improve health and productivity. Whilst promising, there is limited research on the effectiveness of mindfulness interventions in workplace settings.Objective: To examine the feasibility and effectiveness of a Workplace Mindfulness Training (WMT in terms of burnout, psychological well-being, organizational and team climate, and performance.Methods: This is a preliminary field study in four companies. Self-report questionnaires were administered up to a month before, at start of, and right at the end of the WMT, resulting in a pre-intervention and an intervention period. There was no separate control group. A total of 425 participants completed the surveys on the different time points. Linear mixed model analyses were used to analyze the data.Results: When comparing the intervention period with the pre-intervention period, significantly greater improvements were found in measures of burnout (mean difference = 0.3, p < 0.001, perceived stress (mean difference = -0.2, p < 0.001, mindfulness [mean difference = 1.0 for the Freiburg Mindfulness Inventory (FMI and 0.8 for the Mindfulness Attention Awareness Scale (MAAS, both p < 0.001], and well-being (mean difference = 0.4, p < 0.001. Additionally, greater increases in team climate, organizational climate and personal performance were reported during the intervention compared to the pre-intervention period with largest improvements in team cooperation (mean difference = 0.3, p < 0.001, productivity (mean difference = 0.5, p < 0.001, and stress (mean difference = -0.4, p < 0.001. Effect sizes were large for mindfulness (d > 0.8, moderate for well-being, burnout and perceived stress (d = 0.5–0.8, and ranged from low to moderate for organizational and team climate and personal performance (d = 0.2–0.8.Conclusion: These preliminary data suggest that compared to the pre-intervention period, the intervention

  4. The Importance of Integration of Stakeholder Views in Core Outcome Set Development: Otitis Media with Effusion in Children with Cleft Palate.

    Science.gov (United States)

    Harman, Nicola L; Bruce, Iain A; Kirkham, Jamie J; Tierney, Stephanie; Callery, Peter; O'Brien, Kevin; Bennett, Alex M D; Chorbachi, Raouf; Hall, Per N; Harding-Bell, Anne; Parfect, Victoria H; Rumsey, Nichola; Sell, Debbie; Sharma, Ravi; Williamson, Paula R

    2015-01-01

    Approximately 75% of children with cleft palate (CP) have Otitis Media with Effusion (OME) histories. Evidence for the effective management of OME in these children is lacking. The inconsistency in outcome measurement in previous studies has led to a call for the development of a Core Outcome Set (COS). Despite the increase in the number of published COS, involvement of patients in the COS development process, and methods to integrate the views of patients and health professionals, to date have been limited. A list of outcomes measured in previous research was identified through reviewing the literature. Opinion on the importance of each of these outcomes was then sought from key stakeholders: Ear, Nose and Throat (ENT) surgeons, audiologists, cleft surgeons, speech and language therapists, specialist cleft nurses, psychologists, parents and children. The opinion of health professionals was sought in a three round Delphi survey where participants were asked to score each outcome using a bespoke online system. Parents and children were also asked to score outcomes in a survey and provided an in-depth insight into having OME through semi-structured interviews. The results of the Delphi survey, interviews and parent/patient survey were brought together in a final consensus meeting with representation from all stakeholders. A final set of eleven outcomes reached the definition of "consensus in" to form the recommended COS: hearing; chronic otitis media (COM); OME; receptive language skills; speech development; psycho social development; acute otitis media (AOM); cholesteatoma; side effects of treatment; listening skills; otalgia. We have produced a recommendation about the outcomes that should be measured, as a minimum, in studies of the management of OME in children with CP. The development process included input from key stakeholders and used novel methodology to integrate the opinion of healthcare professionals, parents and children.

  5. The Importance of Integration of Stakeholder Views in Core Outcome Set Development: Otitis Media with Effusion in Children with Cleft Palate.

    Directory of Open Access Journals (Sweden)

    Nicola L Harman

    Full Text Available Approximately 75% of children with cleft palate (CP have Otitis Media with Effusion (OME histories. Evidence for the effective management of OME in these children is lacking. The inconsistency in outcome measurement in previous studies has led to a call for the development of a Core Outcome Set (COS. Despite the increase in the number of published COS, involvement of patients in the COS development process, and methods to integrate the views of patients and health professionals, to date have been limited.A list of outcomes measured in previous research was identified through reviewing the literature. Opinion on the importance of each of these outcomes was then sought from key stakeholders: Ear, Nose and Throat (ENT surgeons, audiologists, cleft surgeons, speech and language therapists, specialist cleft nurses, psychologists, parents and children. The opinion of health professionals was sought in a three round Delphi survey where participants were asked to score each outcome using a bespoke online system. Parents and children were also asked to score outcomes in a survey and provided an in-depth insight into having OME through semi-structured interviews. The results of the Delphi survey, interviews and parent/patient survey were brought together in a final consensus meeting with representation from all stakeholders. A final set of eleven outcomes reached the definition of "consensus in" to form the recommended COS: hearing; chronic otitis media (COM; OME; receptive language skills; speech development; psycho social development; acute otitis media (AOM; cholesteatoma; side effects of treatment; listening skills; otalgia.We have produced a recommendation about the outcomes that should be measured, as a minimum, in studies of the management of OME in children with CP. The development process included input from key stakeholders and used novel methodology to integrate the opinion of healthcare professionals, parents and children.

  6. The Importance of Integration of Stakeholder Views in Core Outcome Set Development: Otitis Media with Effusion in Children with Cleft Palate

    Science.gov (United States)

    Harman, Nicola L.; Bruce, Iain A.; Kirkham, Jamie J.; Tierney, Stephanie; Callery, Peter; O'Brien, Kevin; Williamson, Paula R.

    2015-01-01

    Background Approximately 75% of children with cleft palate (CP) have Otitis Media with Effusion (OME) histories. Evidence for the effective management of OME in these children is lacking. The inconsistency in outcome measurement in previous studies has led to a call for the development of a Core Outcome Set (COS). Despite the increase in the number of published COS, involvement of patients in the COS development process, and methods to integrate the views of patients and health professionals, to date have been limited. Methods and Findings A list of outcomes measured in previous research was identified through reviewing the literature. Opinion on the importance of each of these outcomes was then sought from key stakeholders: Ear, Nose and Throat (ENT) surgeons, audiologists, cleft surgeons, speech and language therapists, specialist cleft nurses, psychologists, parents and children. The opinion of health professionals was sought in a three round Delphi survey where participants were asked to score each outcome using a bespoke online system. Parents and children were also asked to score outcomes in a survey and provided an in-depth insight into having OME through semi-structured interviews. The results of the Delphi survey, interviews and parent/patient survey were brought together in a final consensus meeting with representation from all stakeholders. A final set of eleven outcomes reached the definition of “consensus in” to form the recommended COS: hearing; chronic otitis media (COM); OME; receptive language skills; speech development; psycho social development; acute otitis media (AOM); cholesteatoma; side effects of treatment; listening skills; otalgia. Conclusions We have produced a recommendation about the outcomes that should be measured, as a minimum, in studies of the management of OME in children with CP. The development process included input from key stakeholders and used novel methodology to integrate the opinion of healthcare professionals

  7. The ICF Core Sets for hearing loss--researcher perspective. Part I: Systematic review of outcome measures identified in audiological research.

    Science.gov (United States)

    Granberg, Sarah; Dahlström, Jennie; Möller, Claes; Kähäri, Kim; Danermark, Berth

    2014-02-01

    To review the literature in order to identify outcome measures used in research on adults with hearing loss (HL) as part of the ICF Core Sets development project, and to describe study and population characteristics of the reviewed studies. A systematic review methodology was applied using multiple databases. A comprehensive search was conducted and two search pools were created, pool I and pool II. The study population included adults (≥ 18 years of age) with HL and oral language as the primary mode of communication. 122 studies were included. Outcome measures were distinguished by 'instrument type', and 10 types were identified. In total, 246 (pool I) and 122 (pool II) different measures were identified, and only approximately 20% were extracted twice or more. Most measures were related to speech recognition. Fifty-one different questionnaires were identified. Many studies used small sample sizes, and the sex of participants was not revealed in several studies. The low prevalence of identified measures reflects a lack of consensus regarding the optimal outcome measures to use in audiology. Reflections and discussions are made in relation to small sample sizes and the lack of sex differentiation/descriptions within the included articles.

  8. 87Sr/86Sr dating and preliminary interpretation of magnetic susceptibility logs of giant piston cores from the Rio Grande Rise in the South Atlantic

    Science.gov (United States)

    Lacasse, Christian Michel; Santos, Roberto Ventura; Dantas, Elton Luiz; Vigneron, Quentin; de Sousa, Isabela Moreno Cordeiro; Harlamov, Vadim; Lisniowski, Maria Aline; Pessanha, Ivo Bruno Machado; Frazão, Eugênio Pires; Cavalcanti, José Adilson Dias

    2017-12-01

    Giant piston cores recovered from shallow depths (optimized matching with an internationally recognized timescale of 87Sr/86Sr seawater variation through geological times. Depth-to-age conversion of the magnetic susceptibility logs was implemented based on the identification of correlative peaks between cores and the developed 87Sr/86Sr age model. The influence of Northern Hemisphere glaciation is reflected in these new stratigraphic logs by a gradual increase from ∼2.7 Ma in the lower signal of magnetic susceptibility (below background level), to values approaching the arithmetic means, likely reflecting an overall increase in terrigenous input. The Rio Grande Rise cores have very low Plio-Pleistocene sedimentation rates (∼0.4-0.8 cm/ka), similar to gravity cores from the oligotrophic subtropical South Atlantic (below ∼2000 mbsl), and for which an inverse correlation between carbonate content and magnetic susceptibility was established. The coring depths on the Rio Grande Rise encompass strong gradients in oxygen concentration and other seawater parameters that define today's AAIW/UCDW transition. Depth-dependent variation in sedimentation rates since the onset of Northern Hemisphere glaciation coincides with the incursion of intermediate waters (UCDW, AAIW) in response to the overall reduction of NADW export to the Southern Ocean. Background levels of magnetic susceptibility in the cores suggest that this variation is mainly attributed to terrigenous input. The source region of this material has yet to be traced by considering in particular the mineral composition and paramagnetic properties of the detrital clays.

  9. Preliminary Assessment of the Impact on Reactor Vessel dpa Rates Due to Installation of a Proposed Low Enriched Uranium (LEU) Core in the High Flux Isotope Reactor (HFIR)

    Energy Technology Data Exchange (ETDEWEB)

    Daily, Charles R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-10-01

    An assessment of the impact on the High Flux Isotope Reactor (HFIR) reactor vessel (RV) displacements-per-atom (dpa) rates due to operations with the proposed low enriched uranium (LEU) core described by Ilas and Primm has been performed and is presented herein. The analyses documented herein support the conclusion that conversion of HFIR to low-enriched uranium (LEU) core operations using the LEU core design of Ilas and Primm will have no negative impact on HFIR RV dpa rates. Since its inception, HFIR has been operated with highly enriched uranium (HEU) cores. As part of an effort sponsored by the National Nuclear Security Administration (NNSA), conversion to LEU cores is being considered for future HFIR operations. The HFIR LEU configurations analyzed are consistent with the LEU core models used by Ilas and Primm and the HEU balance-of-plant models used by Risner and Blakeman in the latest analyses performed to support the HFIR materials surveillance program. The Risner and Blakeman analyses, as well as the studies documented herein, are the first to apply the hybrid transport methods available in the Automated Variance reduction Generator (ADVANTG) code to HFIR RV dpa rate calculations. These calculations have been performed on the Oak Ridge National Laboratory (ORNL) Institutional Cluster (OIC) with version 1.60 of the Monte Carlo N-Particle 5 (MCNP5) computer code.

  10. Establishment of a Subsidence Superstation in the Mississippi Delta: Integrating sediment core, SET, GPS and vertical strainmeter data to understand subsidence

    Science.gov (United States)

    Steckler, M. S.; Allison, M. A.; Bridgeman, J.; Dixon, T. H.; Hatfield, W.; A Karegar, M.; Tornqvist, T. E.; Zumberge, M. A.; Wyatt, F. K.

    2017-12-01

    There is a great need for coordinated efforts to monitor and better understand subsidence rates in low-elevation coastal zones by integrating different, complementary techniques at carefully selected sites. We present recent efforts to establish a subsidence superstation in the Mississippi Delta. The site is 2 km from the river near Myrtle Grove, Louisiana, at a CRMS (Coastwide Reference Monitoring System) site. The CRMS site consists of a surface elevation table (SET) and marker horizon established in 2008. The surface elevation relative to a rod driven to refusal (26 m) and the sedimentation above the marker horizon is measured semiannually. Adjacent to this site we have added three borehole optical fiber strainmeters that have been providing continuous records of displacement between the near-surface and depths of 10, 26, and 42 m. The instruments provide unprecedented resolution for compaction studies (see Hatfield et al. abstract). We regularly record teleseismic events with amplitudes <1 μm. The records also show a number of days-long compaction and rebound events of less than 1 mm, resulting from changes in the weather and water level. We have attached GPS to each of the wells. For the deepest well, the GPS is anchored to the bottom of the well with the base of the optical strainmeter. For the other two wells, the GPS is anchored to the upper casing of the well. While drilling the wells, a 5" diameter continuous core was collected reaching the Pleistocene boundary at 37 m depth (see Bridgeman et al. abstract). The silty uppermost 10 m, comprised of proximal overbank deposits, reveal up to 5-6 m of subsidence over the past 3000 years. In contrast, the surficial sediments ( 70 cm) are almost entirely organic matter and show little subsidence. The SET shows only 0.4 mm/yr for a 7.4 yr time window. Over the first year, the strainmeters show no long-term compaction or extension greater than ± 0.5 mm. Precise processing of the available GPS data indicates the

  11. Imitation (Rather than Core Language) Predicts Pragmatic Development in Young Children with ASD: A Preliminary Longitudinal Study Using CDI Parental Reports

    Science.gov (United States)

    Miniscalco, Carmela; Rudling, Maja; Råstam, Maria; Gillberg, Christopher; Johnels, Jakob Åsberg

    2014-01-01

    Background: Research in the last decades has clearly pointed to the important role of language and communicative level when trying to understand developmental trajectories in children with autism spectrum disorders (ASD). Aims: The purpose of this longitudinal study was to investigate whether (1) "core language skills", measured as…

  12. Influence of material non-linearity on the thermo-mechanical response of polymer foam cored sandwich structures - FE modelling and preliminary experiemntal results

    DEFF Research Database (Denmark)

    Palleti, Hara Naga Krishna Teja; Thomsen, Ole Thybo; Fruehmann, Richard.K

    In this paper, the polymer foam cored sandwich structures with fibre reinforced composite face sheets will be analyzed using the commercial FE code ABAQUS/Standard® incorporating the material and geometrical non-linearity. Large deformations are allowed which attributes geometric non linearity...

  13. Design and development of small and medium integral reactor core

    International Nuclear Information System (INIS)

    Zee, Sung Quun; Chang, M. H.; Lee, C. C.; Song, J. S.; Cho, B. O.; Kim, K. Y.; Kim, S. J.; Park, S. Y.; Lee, K. B.; Lee, C. H.; Chun, T. H.; Oh, D. S.; In, W. K.; Kim, H. K.; Lee, C. B.; Kang, H. S.; Song, K. N.

    1997-07-01

    Recently, the role of small and medium size integral reactors is remarkable in the heat applications rather than the electrical generations. Such a range of possible applications requires extensive used of inherent safety features and passive safety systems. It also requires ultra-longer cycle operations for better plant economy. Innovative and evolutionary designs such as boron-free operations and related reactor control methods that are necessary for simple reactor system design are demanded for the small and medium reactor (SMR) design, which are harder for engineers to implement in the current large size nuclear power plants. The goals of this study are to establish preliminary design criteria, to perform the preliminary conceptual design and to develop core specific technology for the core design and analysis for System-integrated Modular Advanced ReacTor (SMART) of 330 MWt power. Based on the design criteria of the commercial PWR's, preliminary design criteria will be set up. Preliminary core design concept is going to be developed for the ultra-longer cycle and boron-free operation and core analysis code system is constructed for SMART. (author). 100 refs., 40 tabs., 92 figs

  14. Examining the similarities and differences of OMERACT core sets using the ICF: first step towards an improved domain specification and development of an item pool to measure functioning and health.

    Science.gov (United States)

    Escorpizo, Reuben; Boers, Maarten; Stucki, Gerold; Boonen, Annelies

    2011-08-01

    To contribute to the discussion on a common approach for domain selection in the Outcomes in Rheumatology Clinical Trials (OMERACT) process. First, this article reports on the consistency in the selection and names of the domains of the current OMERACT core set, and next on the comparability of the specifications of concepts that are relevant within the domains. For this purpose, a convenience sample of 4 OMERACT core sets was used: rheumatoid arthritis (RA), psoriatic arthritis (PsA), longitudinal observational studies (LOS) in rheumatology, and ankylosing spondylitis (AS). Domains from the different core sets were compared directly. To be able to compare the specific content of the domains, the concepts contained in the questionnaires that were considered or proposed to measure the domains were identified and linked to the category of the International Classification of Functioning, Disability, and Health (ICF) that best fit that construct. Large differences in the domains, and lack of domain definitions, were noted among the 4 OMERACT core sets. When comparing the concepts in the questionnaires that represent the domains, core sets differed also in the number and type of constructs that were addressed within each of the domains. Especially for the specification of the concepts within the domains Discomfort and Disability, the ICF proved to be useful as external reference to classify the different constructs. Our exercise suggests that the OMERACT process could benefit from a standardized approach to select, define, and specify domains, and demonstrated that the ICF is useful for further classification of the more specific concepts of "what to measure" within the domains. A clear definition and classification of domains and their specification can be useful as a starting point to build a pool of items that could then be used to develop new instruments to assess functioning and health for rheumatological conditions.

  15. Computed tomography of drill cores

    International Nuclear Information System (INIS)

    Taylor, T.

    1985-08-01

    A preliminary computed tomography evaluation of drill cores of granite and sandstone has generated geologically significant data. Density variations as small as 4 percent and fractures as narrow as 0.1 mm were easily detected

  16. Mathematical model for the preliminary analysis of dual-mode space nuclear fission solid core power and propulsion systems, NUROC3A. AMS report No. 1239a

    Energy Technology Data Exchange (ETDEWEB)

    Grey, J.; Chow, S.

    1976-06-30

    The three-volume report describes a dual-mode nuclear space power and propulsion system concept that employs an advanced solid-core nuclear fission reactor coupled via heat pipes to one of several electric power conversion systems. Such a concept could be particularly useful for missions which require both relatively high acceleration (e.g., for planetocentric maneuvers) and high performance at low acceleration (e.g., on heliocentric trajectories or for trajectory shaping). The first volume develops the mathematical model of the system.

  17. Expression, purification, crystallization and preliminary X-ray crystallographic studies of hepatitis B virus core fusion protein corresponding to octahedral particles

    International Nuclear Information System (INIS)

    Kikuchi, Masaki; Iwabuchi, Shinichiro; Kikkou, Tatsuhiko; Noguchi, Keiichi; Odaka, Masafumi; Yohda, Masafumi; Kawata, Masaaki; Sato, Chikara; Matsumoto, Osamu

    2013-01-01

    Novel hepatitis B virus-like particles of recombinant dimeric core–GFP fusion protein were expressed, purified and crystallized. The crystals diffracted to 2.15 Å resolution and belonged to space group F432, with unit-cell parameters a = b = c = 219.7 Å. Recombinant hepatitis B virus core proteins dimerize to form building blocks that are capable of self-assembly into a capsid. A core capsid protein dimer (CPD) linked to a green fluorescent protein variant, EGFP, at the C-terminus has been designed. The recombinant fusion CPD was expressed in Escherichia coli, assembled into virus-like particles (VLPs), purified and crystallized. The single crystal diffracted to 2.15 Å resolution and belonged to the cubic space group F432, with unit-cell parameters a = b = c = 219.7 Å. The fusion proteins assembled into icosahedral VLPs in aqueous solution, but were rearranged into octahedral symmetry through the crystal-packing process under the crystallization conditions

  18. Preliminary Assessment of the Possible BWR Core/Vessel Damage States for Fukushima Daiichi Station Blackout Scenarios Using RELAP/SCDAPSIM

    Directory of Open Access Journals (Sweden)

    C. M. Allison

    2012-01-01

    Full Text Available Immediately after the accident at Fukushima Daiichi, Innovative Systems Software and other members of the international SCDAP Development and Training Program started an assessment of the possible core/vessel damage states of the Fukushima Daiichi Units 1–3. The assessment included a brief review of relevant severe accident experiments and a series of detailed calculations using RELAP/SCDAPSIM. The calculations used a detailed RELAP/SCDAPSIM model of the Laguna Verde BWR vessel and related reactor cooling systems. The Laguna Verde models were provided by the Comision Nacional de Seguridad Nuclear y Salvaguardias, the Mexican nuclear regulatory authority. The initial assessment was originally presented to the International Atomic Energy Agency on March 21 to support their emergency response team and later to our Japanese members to support their Fukushima Daiichi specific analysis and model development.

  19. 210Po/210Pb Activity Ratios as a Possible `Dating Tool' of Ice Cores and Ice-rafted Sediments from the Western Arctic Ocean - Preliminary Results

    Science.gov (United States)

    Krupp, K.; Baskaran, M. M.

    2016-02-01

    We have collected and analyzed a suite of surface snow samples, ice cores, ice-rafted sediments (IRS) and aerosol samples from the Western Arctic for Po-210 and Pb-210 to examine the extent of disequilibrium between this pair to possibly use 210Po/210Pb activity ratio to date different layers of ice cores and time of incorporation of ice-rafted sediments into the sea ice. We have earlier reported that the activity concentrations of 210Pb in IRS vary over an order of magnitude and it is 1-2 orders of magnitude higher than that of the benthic sediments (1-2 dpm/g in benthic sediments compared to 25 to 300 dpm/g in IRS). In this study, we have measured 210Po/210Pb activity ratios in aerosols from the Arctic Ocean to constrain the initial 210Po/210Pb ratio at the time of deposition during precipitation. The 210Po activity concentration in recent snow is compared to surface ice samples. The `age' of IRS incorporation can be calculated as follows: [210Po]measured = [210Po]initial + [210Pb] (1 - exp(-λt)) (1) where λ is the decay constant of 210Po, 138.4 days, and `t' is the in-growth time period. From this equation, `t' can be calculated as follows: t = (-1/λ) [ln (1- ((210Po/210Pb)measured - (210Po/210Pb)initial)] (2) The assumption involved in this approach are: i) there is no preferential uptake of 210Po (highly biogenic - S group); and iii) both 210Po and 210Pb remain as closed system. The calculated age using equation (2) will be discussed and presented.

  20. Toward full MOX core design

    International Nuclear Information System (INIS)

    Rouviere, G.; Guillet, J.L.; Bruna, G.B.; Pelet, J.

    1999-01-01

    This paper presents a selection of the main preliminary results of a study program sponsored by COGEMA and currently carried out by FRAMATOME. The objective of this study is to investigate the feasibility of full MOX core loading in a French 1300 MWe PWR, a recent and widespread standard nuclear power plant. The investigation includes core nuclear design, thermal hydraulic and systems aspects. (authors)

  1. Core BPEL

    DEFF Research Database (Denmark)

    Hallwyl, Tim; Højsgaard, Espen

    The Web Services Business Process Execution Language (WS-BPEL) is a language for expressing business process behaviour based on web services. The language is intentionally not minimal but provides a rich set of constructs, allows omission of constructs by relying on defaults, and supports language......, does not allow omissions, and does not contain ignorable elements. We do so by identifying syntactic sugar, including default values, and ignorable elements in WS-BPEL. The analysis results in a translation from the full language to the core subset. Thus, we reduce the effort needed for working...

  2. Hydrogeologic setting, water budget, and preliminary analysis of ground-water exchange at Lake Starr, a seepage lake in Polk County, Florida

    Science.gov (United States)

    Swancar, Amy; Lee, T.M.; O'Hare, T. M.

    2000-01-01

    Lake Starr, a 134-acre seepage lake of multiple-sinkhole origin on the Lake Wales Ridge of central Florida, was the subject of a detailed water-budget study from August 1996 through July 1998. The study monitored the effects of hydrogeologic setting, climate, and ground-water pumping on the water budget and lake stage. The hydrogeologic setting of the Lake Starr basin differs markedly on the two sides of the lake. Ground water from the surficial aquifer system flows into the lake from the northwest side of the basin, and lake water leaks out to the surficial aquifer system on the southeast side of the basin. Lake Starr and the surrounding surficial aquifer system recharge the underlying Upper Floridan aquifer. The rate of recharge to the Upper Floridan aquifer is determined by the integrity of the intermediate confining unit and by the downward head gradient between the two aquifers. On the inflow side of the lake, the intermediate confining unit is more continuous, allowing ground water from the surficial aquifer system to flow laterally into the lake. Beneath the lake and on the southeast side of the basin, breaches in the intermediate confining unit enhance downward flow to the Upper Floridan aquifer, so that water flows both downward and laterally away from the lake through the ground-water flow system in these areas. An accurate water budget, including evaporation measured by the energy-budget method, was used to calculate net ground-water flow to the lake, and to do a preliminary analysis of the relation of net ground-water fluxes to other variables. Water budgets constructed over different timeframes provided insight on processes that affect ground-water interactions with Lake Starr. Weekly estimates of net ground-water flow provided evidence for the occurrence of transient inflows from the nearshore basin, as well as the short-term effects of head in the Upper Floridan aquifer on ground-water exchange with the lake. Monthly water budgets showed the effects

  3. Microsatellite diversity and broad scale geographic structure in a model legume: building a set of nested core collection for studying naturally occurring variation in Medicago truncatula

    DEFF Research Database (Denmark)

    Ronfort, Joelle; Bataillon, Thomas; Santoni, Sylvain

    2006-01-01

    at representing the genetic diversity of this species with a minimum of repetitiveness. We investigate the patterns of genetic diversity and population structure in a collection of 346 inbred lines representing the breadth of naturally occurring diversity in the Legume plant model Medicago truncatula using 13...... of inbred lines and the core collections are publicly available and will help coordinating efforts for the study of naturally occurring variation in the growing Medicago truncatula community....

  4. Treatment of Individuals with Borderline Personality Disorder Using Dialectical Behavior Therapy in a Community Mental Health Setting: Clinical Application and a Preliminary Investigation

    Science.gov (United States)

    Ben-Porath, Denise D.; Peterson, Gregory A.; Smee, Jacqueline

    2004-01-01

    This article describes an effort to implement and examine dialectical behavior therapy's (DBT) effectiveness in a community mental health setting. Modifications made to address unique aspects of community mental health settings are described. Barriers encountered in implementation of DBT treatment in community mental health settings, such as staff…

  5. Proteomics Core

    Data.gov (United States)

    Federal Laboratory Consortium — Proteomics Core is the central resource for mass spectrometry based proteomics within the NHLBI. The Core staff help collaborators design proteomics experiments in a...

  6. Heterogeneous gas core reactor

    International Nuclear Information System (INIS)

    Han, K.I.

    1977-01-01

    Preliminary investigations of a heterogeneous gas core reactor (HGCR) concept suggest that this potential power reactor offers distinct advantages over other existing or conceptual reactor power plants. One of the most favorable features of the HGCR is the flexibility of the power producing system which allows it to be efficiently designed to conform to a desired optimum condition without major conceptual changes. The arrangement of bundles of moderator/coolant channels in a fissionable gas or mixture of gases makes a truly heterogeneous nuclear reactor core. It is this full heterogeneity for a gas-fueled reactor core which accounts for the novelty of the heterogeneous gas core reactor concept and leads to noted significant advantages over previous gas core systems with respect to neutron and fuel economy, power density, and heat transfer characteristics. The purpose of this work is to provide an insight into the design, operating characteristics, and safety of a heterogeneous gas core reactor system. The studies consist mainly of neutronic, energetic and kinetic analyses of the power producing and conversion systems as a preliminary assessment of the heterogeneous gas core reactor concept and basic design. The results of the conducted research indicate a high potential for the heterogeneous gas core reactor system as an electrical power generating unit (either large or small), with an overall efficiency as high as 40 to 45%. The HGCR system is found to be stable and safe, under the conditions imposed upon the analyses conducted in this work, due to the inherent safety of ann expanding gaseous fuel and the intrinsic feedback effects of the gas and water coolant

  7. LMFBR core design analysis

    International Nuclear Information System (INIS)

    Cho, M.; Yang, J.C.; Yoh, K.C.; Suk, S.D.; Soh, D.S.; Kim, Y.M.

    1980-01-01

    The design parameters of a commercial-scale fast breeder reactor which is currently under construction by regeneration of these data is preliminary analyzed. The analysis of nuclear and thermal characteristics as well as safety features of this reactor is emphasized. And the evaluation of the initial core mentioned in the system description is carried out in the areas of its kinetics and control system, and, at the same time, the flow distribution of sodium and temperature distribution of the initial FBR core system are calculated. (KAERI INIS Section)

  8. Cloning, purification, crystallization and preliminary X-ray crystallographic analysis of SET/TAF-Iß δN from Homo sapiens.

    Science.gov (United States)

    Xu, Zhen; Yang, Weili; Shi, Nuo; Gao, Yongxiang; Teng, Maikun; Niu, Liwen

    2010-08-01

    The histone chaperone SET encoded by the SET gene, which is also known as template-activating factor Iß (TAF-Iß), is a multifunctional molecule that is involved in many biological phenomena such as histone binding, nucleosome assembly, chromatin remodelling, replication, transcription and apoptosis. A truncated SET/TAF-Iß ΔN protein that lacked the first 22 residues of the N-terminus but contained the C-terminal acidic domain and an additional His6 tag at the C-terminus was overexpressed in Escherichia coli and crystallized by the hanging-drop vapour-diffusion method using sodium acetate as precipitant at 283 K. The crystals diffracted to 2.7 A resolution and belonged to space group P4(3)2(1)2.

  9. Cloning, purification, crystallization and preliminary X-ray crystallographic analysis of SET/TAF-Iβ ΔN from Homo sapiens

    International Nuclear Information System (INIS)

    Xu, Zhen; Yang, Weili; Shi, Nuo; Gao, Yongxiang; Teng, Maikun; Niu, Liwen

    2010-01-01

    The SET/TAF-Iβ that lacked the first 22 residues of the N-terminus from Homo sapiens was recombinantly expressed in Escherichia coli and crystallized. X-ray diffraction data were collected to 2.7 Å resolution. The histone chaperone SET encoded by the SET gene, which is also known as template-activating factor Iβ (TAF-Iβ), is a multifunctional molecule that is involved in many biological phenomena such as histone binding, nucleosome assembly, chromatin remodelling, replication, transcription and apoptosis. A truncated SET/TAF-Iβ ΔN protein that lacked the first 22 residues of the N-terminus but contained the C-terminal acidic domain and an additional His 6 tag at the C-terminus was overexpressed in Escherichia coli and crystallized by the hanging-drop vapour-diffusion method using sodium acetate as precipitant at 283 K. The crystals diffracted to 2.7 Å resolution and belonged to space group P4 3 2 1 2

  10. The Psychotherapy Process with Adolescents: A First Pilot Study and Preliminary Comparisons between Different Therapeutic Modalities Using the "Adolescent Psychotherapy Q-Set"

    Science.gov (United States)

    Bychkova, Tetyana; Hillman, Saul; Midgley, Nick; Schneider, Celeste

    2011-01-01

    An innovative methodology is presented for describing the therapeutic processes involved in five types of adolescent treatments: psychoanalysis, psychodynamic psychotherapy, cognitive-behavioural therapy, mentalisation-based treatment and interpersonal psychotherapy. Using the "Adolescent Psychotherapy Q-Set" (APQ), 18 experienced clinicians…

  11. Examining the impact of integrating physical activity on fluid intelligence and academic performance in an elementary school setting: a preliminary investigation.

    Science.gov (United States)

    Reed, Julian A; Einstein, Gilles; Hahn, Erin; Hooker, Steven P; Gross, Virginia P; Kravitz, Jen

    2010-05-01

    To examine the impact of integrating physical activity with elementary curricula on fluid intelligence and academic achievement. A random sample of 3rd grade teachers integrated physical activity into their core curricula approximately 30 minutes a day, 3 days a week from January 2008 to April 2008. Noninvasive fluid intelligence cognitive measures were used along with State-mandated academic achievement tests. Experimental Group children averaged close to 1200 pedometer steps per integration day, thus averaging 3600 steps per week. Children in the Experimental Group performed significantly better on the SPM Fluid Intelligence Test. Children in the Experimental Group also performed significantly better on the Social Studies State mandated academic achievement test. Experimental Group children also received higher scores on the English/Language Arts, Math and Science achievements tests, but were not statistically significant compared with Control Group children. Children classified in Fitnessgram's Healthy Fitness Zone for BMI earned lower scores on many of the SPM Fluid Intelligence components. This investigation provides evidence that movement can influence fluid intelligence and should be considered to promote cognitive development of elementary-age children. Equally compelling were the differences in SPM Fluid Intelligence Test scores for children who were distinguished by Fitnessgram's BMI cut points.

  12. Fundamental energy limits of SET-based Brownian NAND and half-adder circuits. Preliminary findings from a physical-information-theoretic methodology

    Science.gov (United States)

    Ercan, İlke; Suyabatmaz, Enes

    2018-06-01

    The saturation in the efficiency and performance scaling of conventional electronic technologies brings about the development of novel computational paradigms. Brownian circuits are among the promising alternatives that can exploit fluctuations to increase the efficiency of information processing in nanocomputing. A Brownian cellular automaton, where signals propagate randomly and are driven by local transition rules, can be made computationally universal by embedding arbitrary asynchronous circuits on it. One of the potential realizations of such circuits is via single electron tunneling (SET) devices since SET technology enable simulation of noise and fluctuations in a fashion similar to Brownian search. In this paper, we perform a physical-information-theoretic analysis on the efficiency limitations in a Brownian NAND and half-adder circuits implemented using SET technology. The method we employed here establishes a solid ground that enables studying computational and physical features of this emerging technology on an equal footing, and yield fundamental lower bounds that provide valuable insights into how far its efficiency can be improved in principle. In order to provide a basis for comparison, we also analyze a NAND gate and half-adder circuit implemented in complementary metal oxide semiconductor technology to show how the fundamental bound of the Brownian circuit compares against a conventional paradigm.

  13. International consensus on preliminary definitions of improvement in adult and juvenile myositis.

    Science.gov (United States)

    Rider, Lisa G; Giannini, Edward H; Brunner, Hermine I; Ruperto, Nicola; James-Newton, Laura; Reed, Ann M; Lachenbruch, Peter A; Miller, Frederick W

    2004-07-01

    To use a core set of outcome measures to develop preliminary definitions of improvement for adult and juvenile myositis as composite end points for therapeutic trials. Twenty-nine experts in the assessment of myositis achieved consensus on 102 adult and 102 juvenile paper patient profiles as clinically improved or not improved. Two hundred twenty-seven candidate definitions of improvement were developed using the experts' consensus ratings as a gold standard and their judgment of clinically meaningful change in the core set of measures. Seventeen additional candidate definitions of improvement were developed from classification and regression tree analysis, a data-mining decision tree tool analysis. Six candidate definitions specifying percentage change or raw change in the core set of measures were developed using logistic regression analysis. Adult and pediatric working groups ranked the 13 top-performing candidate definitions for face validity, clinical sensibility, and ease of use, in which the sensitivity and specificity were >/=75% in adult, pediatric, and combined data sets. Nominal group technique was used to facilitate consensus formation. The definition of improvement (common to the adult and pediatric working groups) that ranked highest was 3 of any 6 of the core set measures improved by >/=20%, with no more than 2 worse by >/=25% (which could not include manual muscle testing to assess strength). Five and 4 additional preliminary definitions of improvement for adult and juvenile myositis, respectively, were also developed, with several definitions common to both groups. Participants also agreed to prospectively test 6 logistic regression definitions of improvement in clinical trials. Consensus preliminary definitions of improvement were developed for adult and juvenile myositis, and these incorporate clinically meaningful change in all myositis core set measures in a composite end point. These definitions require prospective validation, but they are now

  14. Development and application of a set of mesh-based and age-dependent Chinese family phantoms for radiation protection dosimetry: Preliminary Data for external photon beams

    Science.gov (United States)

    Pi, Yifei; Zhang, Lian; Huo, Wanli; Feng, Mang; Chen, Zhi; Xu, X. George

    2017-09-01

    A group of mesh-based and age-dependent family phantoms for Chinese populations were developed in this study. We implemented a method for deforming original RPI-AM and RPI-AF models into phantoms of different ages: 5, 10 ,15 and adult. More than 120 organs for each model were processed to match with the values of the Chinese reference parameters within 0.5%. All of these phantoms were then converted to voxel format for Monte Carlo simulations. Dose coefficients for adult models were counted to compare with those of RPI-AM and RPI-AF. The results show that there are significant differences between absorbed doses of RPI phantoms and these of our adult phantoms at low energies. Comparisons for the dose coefficients among different ages and genders were also made. it was found that teenagers receive more radiation doses than adults under the same irradiation condition. This set of phantoms can be utilized to estimate dosimetry for Chinese population for radiation protection, medical imaging, and radiotherapy.

  15. A comparison of hysteroscopic mechanical tissue removal with bipolar electrical resection for the management of endometrial polyps in an ambulatory care setting: preliminary results.

    Science.gov (United States)

    Pampalona, Jennifer Rovira; Bastos, Maria Degollada; Moreno, Gemma Mancebo; Pust, Andrea Buron; Montesdeoca, Gemma Escribano; Guerra Garcia, Angel; Pruñonosa, Juan Carles Mateu; Collado, Ramon Carreras; Torras, Pere Bresco

    2015-01-01

    To assess and compare efficacy, pain, and the learning curve associated with diagnostic therapeutic hysteroscopy using mechanical tissue removal versus bipolar electrical resection in the management of endometrial polyps in an ambulatory care setting. A randomized controlled clinical trial (Canadian Task Force classification I). Hospital de Igulada, Barcelona, Spain. A total of 133 patients diagnosed with endometrial polyp(s) were included and randomly assigned to 1 of the 2 hysteroscopic methods. Criteria assessed were total hysteroscopy time, full polypectomy procedure time, pain experienced by patients, and learning curve of staff in training. The average time to perform total hysteroscopy using the mechanical tissue removal system (TRUCLEAR 5.0 System; Smith & Nephew Inc., Andover, MD) was 6 minutes 49 seconds versus 11 minutes 37 seconds required for the bipolar electrosurgery system (GYNECARE VERSAPOINT; Ethicon Inc, Somerville, NJ) (p .05). A study of the residents' learning curve showed a higher level of autonomy with hysteroscopy using the TRUCLEAR Tissue Removal System with which residents showed a higher level of confidence compared with hysteroscopy with the VERSAPOINT Bipolar Electrosurgery System. In hysteroscopic polypectomy, the mechanical tissue removal system was significantly faster, achieved a greater success rate for complete polypectomy, and required a shorter learning curve from staff being trained in the management of endometrial polyps when compared with bipolar electrical resection. Copyright © 2015 AAGL. Published by Elsevier Inc. All rights reserved.

  16. Preliminary evidence for associations between molecular markers and quantitative traits in a set of bread wheat (Triticum aestivum L.) cultivars and breeding lines.

    Science.gov (United States)

    Abdollahi Mandoulakani, Babak; Nasri, Shilan; Dashchi, Sahar; Arzhang, Sorour; Bernousi, Iraj; Abbasi Holasou, Hossein

    The identification of polymorphic markers associated with various quantitative traits allows us to test their performance for the exploitation of the extensive quantitative variation maintained in gene banks. In the current study, a set of 97 wheat germplasm accessions including 48 cultivars and 49 breeding lines were evaluated for 18 agronomic traits. The accessions were also genotyped with 23 ISSR, nine IRAP and 20 REMAP markers, generating a total of 658 clear and scorable bands, 86% of which were polymorphic. Both neighbor-joining dendrogram and Bayesian analysis of clustering of individuals revealed that the accessions could be divided into four genetically distinct groups, indicating the presence of a population structure in current wheat germplasm. Associations between molecular markers and 18 agronomic traits were analyzed using the mixed linear model (MLM) approach. A total of 94 loci were found to be significantly associated with agronomic traits (P≤0.01). The highest number of bands significantly associated with the 18 traits varied from 11 for number of spikelets spike -1 (NSS) to two for grain yield in row (GRY). Loci ISSR16-9 and REMAP13-10 were associated with three different traits. The results of the current study provide useful information about the performance of retrotransposon-based and ISSR molecular markers that could be helpful in selecting potentially elite gene bank samples for wheat-breeding programs. Copyright © 2017 Académie des sciences. Published by Elsevier Masson SAS. All rights reserved.

  17. A new set-up for simultaneous high-precision measurements of CO2, δ13C-CO2 and δ18O-CO2 on small ice core samples

    Science.gov (United States)

    Jenk, Theo Manuel; Rubino, Mauro; Etheridge, David; Ciobanu, Viorela Gabriela; Blunier, Thomas

    2016-08-01

    Palaeoatmospheric records of carbon dioxide and its stable carbon isotope composition (δ13C) obtained from polar ice cores provide important constraints on the natural variability of the carbon cycle. However, the measurements are both analytically challenging and time-consuming; thus only data exist from a limited number of sampling sites and time periods. Additional analytical resources with high analytical precision and throughput are thus desirable to extend the existing datasets. Moreover, consistent measurements derived by independent laboratories and a variety of analytical systems help to further increase confidence in the global CO2 palaeo-reconstructions. Here, we describe our new set-up for simultaneous measurements of atmospheric CO2 mixing ratios and atmospheric δ13C and δ18O-CO2 in air extracted from ice core samples. The centrepiece of the system is a newly designed needle cracker for the mechanical release of air entrapped in ice core samples of 8-13 g operated at -45 °C. The small sample size allows for high resolution and replicate sampling schemes. In our method, CO2 is cryogenically and chromatographically separated from the bulk air and its isotopic composition subsequently determined by continuous flow isotope ratio mass spectrometry (IRMS). In combination with thermal conductivity measurement of the bulk air, the CO2 mixing ratio is calculated. The analytical precision determined from standard air sample measurements over ice is ±1.9 ppm for CO2 and ±0.09 ‰ for δ13C. In a laboratory intercomparison study with CSIRO (Aspendale, Australia), good agreement between CO2 and δ13C results is found for Law Dome ice core samples. Replicate analysis of these samples resulted in a pooled standard deviation of 2.0 ppm for CO2 and 0.11 ‰ for δ13C. These numbers are good, though they are rather conservative estimates of the overall analytical precision achieved for single ice sample measurements. Facilitated by the small sample requirement

  18. Characteristics of fast reactor core designs and closed fuel cycle

    International Nuclear Information System (INIS)

    Poplavsky, V.M.; Eliseev, V.A.; Matveev, V.I.; Khomyakov, Y.S.; Tsyboulya, A.M.; Tsykunov, A.G.; Chebeskov, A.N.

    2007-01-01

    On the basis of the results of recent studies, preliminary basic requirements related to characteristics of fast reactor core and nuclear fuel cycle were elaborated. Decreasing reactivity margin due to approaching breeding ratio to 1, requirements to support non-proliferation of nuclear weapons, and requirements to decrease amount of radioactive waste are under consideration. Several designs of the BN-800 reactor core have been studied. In the case of MOX fuel it is possible to reach a breeding ratio about 1 due to the use of larger size of fuel elements with higher fuel density. Keeping low axial fertile blanket that would be reprocessed altogether with the core, it is possible to set up closed fuel cycle with the use of own produced plutonium only. Conceptual core designs of advanced commercial reactor BN-1800 with MOX and nitride fuel are also under consideration. It has been shown that it is expedient to use single enrichment fuel core design in this reactor in order to reach sufficient flattening and stability of power rating in the core. The main feature of fast reactor fuel cycle is a possibility to utilize plutonium and minor actinides which are the main contributors to the long-living radiotoxicity in irradiated nuclear fuel. The results of comparative analytical studies on the risk of plutonium proliferation in case of open and closed fuel cycle of nuclear power are also presented in the paper. (authors)

  19. Special processor for in-core control systems

    International Nuclear Information System (INIS)

    Golovanov, M.N.; Duma, V.R.; Levin, G.L.; Mel'nikov, A.V.; Polikanin, A.V.; Filatov, V.P.

    1978-01-01

    The BUTs-20 special processor is discussed, designed to control the units of the in-core control equipment which are incorporated into the VECTOR communication channel, and to provide preliminary data processing prior to computer calculations. A set of instructions and flowsheet of the processor, organization of its communication with memories and other units of the system are given. The processor components: a control unit and an arithmetic logical unit are discussed. It is noted that the special processor permits more effective utilization of the computer time

  20. Calculations of core-excited states in Li

    International Nuclear Information System (INIS)

    Verbockhaven, G.; Hansen, J.E.

    1999-01-01

    We report on progress in the calculation of three-electron states making use of B-spline basis sets. In particular we discuss the advantages and disadvantages of using a Hartree-Fock basis (expanded in B-splines) compared to the use of hydrogenic basis states. Preliminary results are presented for the 2 S terms in Li below the 1s2s 3 S limit at 64.4 eV. The 2 S terms have been studied less extensively than other core-excited states in Li. In this particular case the choice of basis has a large influence on the quality of the results. (orig.)

  1. Transformer core

    NARCIS (Netherlands)

    Mehendale, A.; Hagedoorn, Wouter; Lötters, Joost Conrad

    2008-01-01

    A transformer core includes a stack of a plurality of planar core plates of a magnetically permeable material, which plates each consist of a first and a second sub-part that together enclose at least one opening. The sub-parts can be fitted together via contact faces that are located on either side

  2. Transformer core

    NARCIS (Netherlands)

    Mehendale, A.; Hagedoorn, Wouter; Lötters, Joost Conrad

    2010-01-01

    A transformer core includes a stack of a plurality of planar core plates of a magnetically permeable material, which plates each consist of a first and a second sub-part that together enclose at least one opening. The sub-parts can be fitted together via contact faces that are located on either side

  3. Preliminary HECTOR analysis by Dragon

    Energy Technology Data Exchange (ETDEWEB)

    Presser, W; Woloch, F

    1972-06-02

    From the different cores measured in HECTOR, only ACH 4/B-B was selected for the Dragon analysis, since it presented the largest amount of uniform fuel loading in the central test region and is therefore nearest to an infinite lattice. Preliminary results are discussed.

  4. Preliminary study of a flux converter for experimental reactor

    International Nuclear Information System (INIS)

    Malouch, M.F.

    1998-01-01

    The purpose of this project is to define the characteristics of a flux converter dedicated to increase the fast neutron flux in irradiation devices placed in the core of Osiris experimental reactor. This preliminary work has dealt with the neutronic and thermal-hydraulic aspects of this problem. The synthesis of the results produced by the codes APOLLO2, DAIXY, MERCURE5.3 and FLICA-3M shows that a cylindrical converter equipped with 5 fissile rings can enhance the fast flux by a 35% factor in an experimental device set in its center. (A.C.)

  5. Core lifter

    Energy Technology Data Exchange (ETDEWEB)

    Pavlov, N G; Edel' man, Ya A

    1981-02-15

    A core lifter is suggested which contains a housing, core-clamping elements installed in the housing depressions in the form of semirings with projections on the outer surface restricting the rotation of the semirings in the housing depressions. In order to improve the strength and reliability of the core lifter, the semirings have a variable transverse section formed from the outside by the surface of the rotation body of the inner arc of the semiring aroung the rotation axis and from the inner a cylindrical surface which is concentric to the outer arc of the semiring. The core-clamping elements made in this manner have the possibility of freely rotating in the housing depressions under their own weight and from contact with the core sample. These semirings do not have weakened sections, have sufficient strength, are inserted into the limited ring section of the housing of the core lifter without reduction in its through opening and this improve the reliability of the core lifter in operation.

  6. Improvements to core-catchers

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, T C.W.

    1969-07-22

    A core catcher consists of a generally annular holder adapted to be contained within a core barrel with sets of dogs circumferentially disposed in the holder. Each set of dogs consists of at least 2 dogs of different lengths pivotally mounted in the holder to swing inward. The dogs in each set are vertically superimposed. They are of upward decreasing length, with the arc of swing of the vertically adjacent dogs overlapping. (8 claims)

  7. Reactor core

    International Nuclear Information System (INIS)

    Azekura, Kazuo; Kurihara, Kunitoshi.

    1992-01-01

    In a BWR type reactor, a great number of pipes (spectral shift pipes) are disposed in the reactor core. Moderators having a small moderating cross section (heavy water) are circulated in the spectral shift pipes to suppress the excess reactivity while increasing the conversion ratio at an initial stage of the operation cycle. After the intermediate stage of the operation cycle in which the reactor core reactivity is lowered, reactivity is increased by circulating moderators having a great moderating cross section (light water) to extend the taken up burnup degree. Further, neutron absorbers such as boron are mixed to the moderator in the spectral shift pipe to control the concentration thereof. With such a constitution, control rods and driving mechanisms are no more necessary, to simplify the structure of the reactor core. This can increase the fuel conversion ratio and control great excess reactivity. Accordingly, a nuclear reactor core of high conversion and high burnup degree can be attained. (I.N.)

  8. Ice Cores

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Records of past temperature, precipitation, atmospheric trace gases, and other aspects of climate and environment derived from ice cores drilled on glaciers and ice...

  9. Space reactor preliminary mechanical design

    International Nuclear Information System (INIS)

    Meier, K.L.

    1983-01-01

    An analysis was performed on the SABRE reactor space power system to determine the effect of the number and size of heat pipes on the design parameters of the nuclear subsystem. Small numbers of thin walled heat pipes were found to give a lower subsystem mass, but excessive fuel swelling resulted. The SP-100 preliminary design uses 120 heat pipes because of acceptable fuel swelling and a minimum nuclear subsystem mass of 1875 kg. Salient features of the reactor preliminary design are: individual fuel modules, ZrO 2 block core mounts, bolted collar fuel module restraints, and a BeO central plug

  10. Reactor core

    International Nuclear Information System (INIS)

    Matsuura, Tetsuaki; Nomura, Teiji; Tokunaga, Kensuke; Okuda, Shin-ichi

    1990-01-01

    Fuel assemblies in the portions where the gradient of fast neutron fluxes between two opposing faces of a channel box is great are kept loaded at the outermost peripheral position of the reactor core also in the second operation cycle in the order to prevent interference between a control rod and the channel box due to bending deformation of the channel box. Further, the fuel assemblies in the second row from the outer most periphery in the first operation cycle are also kept loaded at the second row in the second operation cycle. Since the gradient of the fast neutrons in the reactor core is especially great at the outer circumference of the reactor core, the channel box at the outer circumference is bent such that the surface facing to the center of the reactor core is convexed and the channel box in the second row is also bent to the identical direction, the insertion of the control rod is not interfered. Further, if the positions for the fuels at the outermost periphery and the fuels in the second row are not altered in the second operation cycle, the gaps are not reduced to prevent the interference between the control rod and the channel box. (N.H.)

  11. Trial-Based Thought Record (TBTR): preliminary data on a strategy to deal with core beliefs by combining sentence reversion and the use of analogy with a judicial process.

    Science.gov (United States)

    Oliveira, Irismar Reis de

    2008-03-01

    To propose the Trial-Based Thought Record, a modified, 7-column thought record addressing core beliefs by sentence reversion and the analogy to a trial. Clients (n = 30) participated in a simulation of a trial and exhibited shifts in their adherence to core beliefs and in the intensity of corresponding emotions after each step (investigation, prosecutor s plea, defense attorney s plea, prosecutor s second plea, defense attorney s second plea, and jury verdict) during a session. Significant mean reductions existed between percent values after investigation (taken as baseline) and defense attorney s plea (p < 0.001), and after the jury s verdict, either in beliefs (p < 0.001) or in intensity of emotions (p < 0.001). Significant differences also emerged between the defense attorney s first and second pleas (p = 0.009) and between the defense attorney s second plea and jury s verdict concerning core beliefs (p = 0.005) and emotions (p = 0.02). Trial-Based Thought Record may at least temporarily help patients constructively reduce attachment to negative core beliefs and corresponding emotions.

  12. Emergency core cooling device

    International Nuclear Information System (INIS)

    Suzaki, Kiyoshi; Inoue, Akihiro.

    1979-01-01

    Purpose: To improve core cooling effect by making the operation region for a plurality of water injection pumps more broader. Constitution: An emergency reactor core cooling device actuated upon failure of recycling pipe ways is adapted to be fed with cooling water through a thermal sleeve by way of a plurality of water injection pump from pool water in a condensate storage tank and a pressure suppression chamber as water feed source. Exhaust pipes and suction pipes of each of the pumps are connected by way of switching valves and the valves are switched so that the pumps are set to a series operation if the pressure in the pressure vessel is high and the pumps are set to a parallel operation if the pressure in the pressure vessel is low. (Furukawa, Y.)

  13. Initial validation of the Argentinean Spanish version of the PedsQL™ 4.0 Generic Core Scales in children and adolescents with chronic diseases: acceptability and comprehensibility in low-income settings

    Directory of Open Access Journals (Sweden)

    Bauer Gabriela

    2008-08-01

    Full Text Available Abstract Background To validate the Argentinean Spanish version of the PedsQL™ 4.0 Generic Core Scales in Argentinean children and adolescents with chronic conditions and to assess the impact of socio-demographic characteristics on the instrument's comprehensibility and acceptability. Reliability, and known-groups, and convergent validity were tested. Methods Consecutive sample of 287 children with chronic conditions and 105 healthy children, ages 2–18, and their parents. Chronically ill children were: (1 attending outpatient clinics and (2 had one of the following diagnoses: stem cell transplant, chronic obstructive pulmonary disease, HIV/AIDS, cancer, end stage renal disease, complex congenital cardiopathy. Patients and adult proxies completed the PedsQL™ 4.0 and an overall health status assessment. Physicians were asked to rate degree of health status impairment. Results The PedsQL™ 4.0 was feasible (only 9 children, all 5 to 7 year-olds, could not complete the instrument, easy to administer, completed without, or with minimal, help by most children and parents, and required a brief administration time (average 5–6 minutes. People living below the poverty line and/or low literacy needed more help to complete the instrument. Cronbach Alpha's internal consistency values for the total and subscale scores exceeded 0.70 for self-reports of children over 8 years-old and parent-reports of children over 5 years of age. Reliability of proxy-reports of 2–4 year-olds was low but improved when school items were excluded. Internal consistency for 5–7 year-olds was low (α range = 0.28–0.76. Construct validity was good. Child self-report and parent proxy-report PedsQL™ 4.0 scores were moderately but significantly correlated (ρ = 0.39, p Conclusion Results suggest that the Argentinean Spanish PedsQL™ 4.0 is suitable for research purposes in the public health setting for children over 8 years old and parents of children over 5 years old

  14. Critical experiments of JMTRC MEU cores

    International Nuclear Information System (INIS)

    Nagaoka, Y.; Takeda, K.; Shimakawa, S.; Koike, S.; Oyamada, R.

    1984-01-01

    The JMTRC, the critical facility of the Japan Materials Testing Reactor (JMTR), went critical on August 29, 1983, with 14 medium enriched uranium (MEU, 45%) fuel elements. Experiments are now being carried out to measure the change in various reactor characteristics between the previous HEU core and the new MEU fueled core. This paper describes the results obtained thus far on critical mass, excess reactivity, control rod worths and flux distribution, including preliminary neutronics calculations for the experiments using the SRAC code. (author)

  15. Solid0Core Heat-Pipe Nuclear Batterly Type Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Ehud Greenspan

    2008-09-30

    This project was devoted to a preliminary assessment of the feasibility of designing an Encapsulated Nuclear Heat Source (ENHS) reactor to have a solid core from which heat is removed by liquid-metal heat pipes (HP).

  16. Advantages of iron core in a tokamak

    International Nuclear Information System (INIS)

    Bettis, E.S.; Ballou, J.K.; Becraft, W.R.; Peng, Y.K.M.; Watts, H.L.

    1977-01-01

    A quantitative comparison of the iron core vs air core concepts was carried out on a preliminary basis by using a representative tokamak reactor design with the following self-consistent reference parameters. In the area of plasma engineering, poloidal field and MHD equilibrium considerations with an unsaturated iron core is discussed. The question of proper poloidal field coils to maintain D-shaped plasmas of relatively high anti β (7%) with a saturated iron core is also discussed. Estimates of the required iron core size, volt seconds, magnetic flux and its influence on force loading on the superconducting toroidal field coils are shown. Conceptual designs of the mechanical structure of an iron core device are presented. Favorable impacts on the OH power supply cost and complexity are indicated

  17. Initial Continuous Chemistry Results From The Roosevelt Island Ice Core (RICE)

    Science.gov (United States)

    Kjær, H. A.; Vallelonga, P. T.; Simonsen, M. F.; Neff, P. D.; Bertler, N. A. N.; Svensson, A.; Dahl-Jensen, D.

    2014-12-01

    The Roosevelt Island ice core (79.36° S, -161.71° W) was drilled in 2011-13 at the top of the Roosevelt Island ice dome, a location surrounded by the Ross ice shelf. The RICE ice core provides a unique opportunity to look into the past evolution of the West Antarctic Ice sheet. Further the site has high accumulation; 0.26 m of ice equivalent is deposited annually allowing annual layer determination for many chemical parameters. The RICE core was drilled to bedrock and has a total length of 763 metres. Preliminary results derived from water isotopes suggest that the oldest ice reaches back to the Eemian, with the last glacial being compressed in the bottom 60 metres. We present preliminary results from the RICE ice core including continuous measurements of acidity using an optical dye method, insoluble dust particles, conductivity and calcium. The core was analyzed at the New Zealand National Ice Core Research Facility at GNS Science in Wellington. The analytical set up used to determine climate proxies in the ice core was a modified version of the Copenhagen CFA system (Bigler et al., 2011). Key volcanic layers have been matched to those from the WAIS record (Sigl et al., 2013). A significant anti-correlation between acidity and calcium was seen in the Holocene part of the record. Due to the proximity to the ocean a large fraction of the calcium originates from sea salt and is in phase with total conductivity and sodium. In combination with the insoluble dust record, calcium has been apportioned into ocean-related and dust-related sources. Variability over the Holocene is presented and attributed to changing inputs of marine and dust aerosols.

  18. First results with the experimental set-up at a Bugey reactor: neutrino oscillations, search of axions

    International Nuclear Information System (INIS)

    Hoummada, A.

    1982-07-01

    This work presents an experimental set-up at the Bugey PWR reactor to put into evidence neutrino oscillations. The first part describes a neutrino detector specially designed for the investigation of neutrino oscillations at two distances (13.50 m and 19 m) under the core of the reactor. Preliminary analysis are presented. The second part reports a search for axions, using the neutrino detector well-shielded volume. Created in competition with electro magnetic transitions, axion should be produced in abondance in the reactor core. This experiment excludes the existence of the axion of the standard model [fr

  19. Preliminary ATWS analysis for the IRIS PRA

    International Nuclear Information System (INIS)

    Maddalena Barra; Marco S Ghisu; David J Finnicum; Luca Oriani

    2005-01-01

    Full text of publication follows: The pressurized light water cooled, medium power (1000 MWt) IRIS (International Reactor Innovative and Secure) has been under development for four years by an international consortium of over 21 organizations from ten countries. The plant conceptual design was completed in 2001 and the preliminary design is nearing completion. The pre-application licensing process with NRC started in October, 2002. IRIS has been primarily focused on establishing a design with innovative safety characteristics. The first line of defense in IRIS is to eliminate event initiators that could potentially lead to core damage. In IRIS, this concept is implemented through the 'safety by design' approach, which allows to minimize the number and complexity of the safety systems and required operator actions. The end result is a design with significantly reduced complexity and improved operability, and extensive plant simplifications to enhance construction. To support the optimization of the plant design and confirm the effectiveness of the safety by design approach in mitigating or eliminating events and thus providing a significant reduction in the probability of severe accidents, the PRA is being used as an integral part of the design process. A preliminary but extensive Level 1 PRA model has been developed to support the pre-application licensing of the IRIS design. As a result of the Preliminary IRIS PRA, an optimization of the design from a reliability point of view was completed, and an extremely low (about 1.2 E -8 ) core damage frequency (CDF) was assessed to confirm the impact of the safety by design approach. This first assessment is a result of a PRA model including internal initiating events. During this assessment, several assumptions were necessary to complete the CDF evaluation. In particular Anticipated Transients Without Scram (ATWS) were not included in this initial assessment, because their contribution to core damage frequency was assumed

  20. Core body temperature in obesity.

    Science.gov (United States)

    Heikens, Marc J; Gorbach, Alexander M; Eden, Henry S; Savastano, David M; Chen, Kong Y; Skarulis, Monica C; Yanovski, Jack A

    2011-05-01

    A lower core body temperature set point has been suggested to be a factor that could potentially predispose humans to develop obesity. We tested the hypothesis that obese individuals have lower core temperatures than those in normal-weight individuals. In study 1, nonobese [body mass index (BMI; in kg/m(2)) temperature-sensing capsules, and we measured core temperatures continuously for 24 h. In study 2, normal-weight (BMI of 18-25) and obese subjects swallowed temperature-sensing capsules to measure core temperatures continuously for ≥48 h and kept activity logs. We constructed daily, 24-h core temperature profiles for analysis. Mean (±SE) daily core body temperature did not differ significantly between the 35 nonobese and 46 obese subjects (36.92 ± 0.03°C compared with 36.89 ± 0.03°C; P = 0.44). Core temperature 24-h profiles did not differ significantly between 11 normal-weight and 19 obese subjects (P = 0.274). Women had a mean core body temperature ≈0.23°C greater than that of men (36.99 ± 0.03°C compared with 36.76 ± 0.03°C; P body temperature. It may be necessary to study individuals with function-altering mutations in core temperature-regulating genes to determine whether differences in the core body temperature set point affect the regulation of human body weight. These trials were registered at clinicaltrials.gov as NCT00428987 and NCT00266500.

  1. General description of preliminary design of an experimental fusion reactor and the future problems

    International Nuclear Information System (INIS)

    Sako, Kiyoshi

    1976-01-01

    Recently, the studies on plasma physics has progressed rapidly, and promising experimental data emerged successively. Especially expectation mounts high that Tokamak will develop into power reactors. In Japan, the construction of large plasma devices such as JT-60 of JAERI is going to start, and after several years, the studies on plasma physics will come to the end of first stage, then the main research and development will be directed to power reactors. The studies on the design of practical fusion reactors have been in progress since 1973 in JAERI, and the preliminary design is being carried out. The purposes of the preliminary design are the clarification of the concept of the experimental reactor and the requirements for the studies on core plasma, the examination of the problems for developing main components and systems of the reactor, and the development of design technology. The experimental reactor is the quasi-steady reactor of 100 MW fusion reaction output, and the conditions set for the design and the basis of their setting are explained. The outline of the design, namely core plasma, blankets, superconductive magnets and the shielding with them, vacuum wall, neutral particle injection heating device, core fuel supply and exhaust system, and others, is described. In case of scale-up the reactor structural material which can withstand neutron damage must be developed. (Kako, I.)

  2. VLBA DETERMINATION OF THE DISTANCE TO NEARBY STAR-FORMING REGIONS. IV. A PRELIMINARY DISTANCE TO THE PROTO-HERBIG AeBe STAR EC 95 IN THE SERPENS CORE

    International Nuclear Information System (INIS)

    Dzib, Sergio; Loinard, Laurent; Rodriguez, Luis F.; Mioduszewski, Amy J.; Boden, Andrew F.; Torres, Rosa M.

    2010-01-01

    Using the Very Long Base Array, we observed the young stellar object EC 95 in the Serpens cloud core at eight epochs from 2007 December to 2009 December. Two sources are detected in our field and are shown to form a tight binary system. The primary (EC 95a) is a 4-5 M sun proto-Herbig AeBe object (arguably the youngest such object known), whereas the secondary (EC 95b) is most likely a low-mass T Tauri star. Interestingly, both sources are non-thermal emitters. While T Tauri stars are expected to power a corona because they are convective while they go down the Hayashi track, intermediate-mass stars approach the main sequence on radiative tracks. Thus, they are not expected to have strong superficial magnetic fields, and should not be magnetically active. We review several mechanisms that could produce the non-thermal emission of EC 95a and argue that the observed properties of EC 95a might be most readily interpreted if it possessed a corona powered by a rotation-driven convective layer. Using our observations, we show that the trigonometric parallax of EC 95 is π = 2.41 ± 0.02 mas, corresponding to a distance of 414.9 +4.4 -4.3 pc. We argue that this implies a distance to the Serpens core of 415 ± 5 pc and a mean distance to the Serpens cloud of 415 ± 25 pc. This value is significantly larger than previous estimates (d ∼ 260 pc) based on measurements of the extinction suffered by stars in the direction of Serpens. A possible explanation for this discrepancy is that these previous observations picked out foreground dust clouds associated with the Aquila Rift system rather than Serpens itself.

  3. Conceptual core model for the reactor core test

    International Nuclear Information System (INIS)

    Swenson, L.D.

    1970-01-01

    Several design options for the ZrH Flight System Reactor were investigated which involved tradeoffs of core excess reactivity, reactor control, coolant mixing and cladding thickness. A design point was selected which is to be the basis for more detailed evaluation in the preliminary design phase. The selected design utilizes 295 elements with 0.670 inch element-to-element pitch, 32 mil thick Incoloy cladding, 18.00 inches long fuel meat, hydrogen content of 6.3 x 10 22 atoms/cc fuel, 10.5 w/o uranium, and a spiraled fin configuration with alternate elements having fins with spiral to the right, spiral to the left, and no fin at all (R-L-N fin configuration). Fin height is 30 mils for the center region of the core and 15 mils for the outer region. (U.S.)

  4. Degraded core studies at INEL

    International Nuclear Information System (INIS)

    Buescher, B.J.; Howe, T.M.; Miller, R.W.

    1982-01-01

    During 1980, planning of prototypical severe fuel damage tests to be conducted in the Power Burst Facility (PBF) to investigate fuel behavior in severe accidents up to temperatures of 2400 0 K was initiated. This first series of tests is designated Phase I. Also, a code development effort was initiated to provide a reliable predictive tool for core behavior during severe accidents. During 1981, an assessment of capabilities and preliminary planning were begun for an in-pile experimental program to investigate the behavior of larger arrays of previously irradiated fuel rods at temperatures through UO 2 melting. This latter series of tests is designated Phase II

  5. RB reactor benchmark cores

    International Nuclear Information System (INIS)

    Pesic, M.

    1998-01-01

    A selected set of the RB reactor benchmark cores is presented in this paper. The first results of validation of the well-known Monte Carlo MCNP TM code and adjoining neutron cross section libraries are given. They confirm the idea for the proposal of the new U-D 2 O criticality benchmark system and support the intention to include this system in the next edition of the recent OECD/NEA Project: International Handbook of Evaluated Criticality Safety Experiment, in near future. (author)

  6. Secondary biogenic coal seam gas reservoirs in New Zealand: A preliminary assessment of gas contents

    Energy Technology Data Exchange (ETDEWEB)

    Butland, Carol I. [Department of Geological Sciences, University of Canterbury, Private Bag 4800, Christchurch (New Zealand); Moore, Tim A. [Department of Geological Sciences, University of Canterbury, Private Bag 4800, Christchurch (New Zealand); Solid Energy NZ Ltd., P.O. Box 1303, Christchurch (New Zealand)

    2008-10-02

    Four coal cores, one from the Huntly (Eocene), two from the Ohai (Cretaceous) and one from the Greymouth (Cretaceous) coalfields, were sampled and analysed in terms of gas content and coal properties. The coals vary in rank from subbituminous B-A (Huntly) to subbituminous C-A (Ohai), and high volatile A bituminous (Greymouth). Average gas contents were 1.60 m{sup 3}/t (s 0.2) in the Huntly core, 4.80 m{sup 3}/t (s = 0.8) in the Ohai cores, and 2.39 m{sup 3}/t (s = 0.8) in the Greymouth core. The Ohai core not only contained more gas but also had the highest saturation (75%) compared with the Huntly (33%) and Greymouth (45%) cores. Carbon isotopes indicate that the Ohai gas is more mature, containing higher {delta}{sup 13}C isotopes values than either the Huntly or Greymouth gas samples. This may indicate that the gas was derived from a mixed biogenic and thermogenic source. The Huntly and Greymouth gases appear to be derived solely from a secondary biogenic (by CO{sub 2} reduction) source. Although the data set is limited, preliminary analysis indicates that ash yield is the dominant control on gas volume in all samples where the ash yield was above 10%. Below 10%, the amount of gas variation is unrelated to ash yield. Although organic content has some influence on gas volume, associations are basin and/or rank dependent. In the Huntly core total gas content and structured vitrinite increase together. Although this relationship does not appear for the other core data for the Ohai SC3 core, lost gas and fusinite are associated whereas gelovitrinite (unstructured vitrinite) correlates positively with residual gas for the Greymouth data. (author)

  7. Side core lifter

    Energy Technology Data Exchange (ETDEWEB)

    Edelman, Ya A

    1982-01-01

    A side core lifter is proposed which contains a housing with guide slits and a removable core lifter with side projections on the support section connected to the core receiver. In order to preserve the structure of the rock in the core sample by means of guaranteeing rectilinear movement of the core lifter in the rock, the support and core receiver sections are hinged. The device is equipped with a spring for angular shift in the core-reception part.

  8. An iterative homogenization technique that preserves assembly core exchanges

    International Nuclear Information System (INIS)

    Mondot, Ph.; Sanchez, R.

    2003-01-01

    A new interactive homogenization procedure for reactor core calculations is proposed that requires iterative transport assembly and diffusion core calculations. At each iteration the transport solution of every assembly type is used to produce homogenized cross sections for the core calculation. The converged solution gives assembly fine multigroup transport fluxes that preserve macro-group assembly exchanges in the core. This homogenization avoids the periodic lattice-leakage model approximation and gives detailed assembly transport fluxes without need of an approximated flux reconstruction. Preliminary results are given for a one-dimensional core model. (authors)

  9. Pollutant plume delineation from tree core sampling using standardized ranks

    DEFF Research Database (Denmark)

    Wahyudi, Agung; Bogaert, Patrick; Trapp, Stefan

    2012-01-01

    There are currently contradicting results in the literature about the way chloroethene (CE) concentrations from tree core sampling correlate with those from groundwater measurements. This paper addresses this issue by focusing on groundwater and tree core datasets in CE contaminated site, Czech...... Republic. Preliminary analyses revealed strongly and positively skewed distributions for the tree core dataset, with an intra-tree variability accounting for more than 80% of the total variability, while the spatial analyses based on variograms indicated no obvious spatial pattern for CE concentration...... groundwater and tree core measurements. Nonetheless, tree core sampling and analysis proved to be a quick and inexpensive semi-quantitative method and a useful tool....

  10. North Korean refugee doctors' preliminary examination scores

    Directory of Open Access Journals (Sweden)

    Sung Uk Chae

    2016-12-01

    Full Text Available Purpose Although there have been studies emphasizing the re-education of North Korean (NK doctors for post-unification of the Korean Peninsula, study on the content and scope of such re-education has yet to be conducted. Researchers intended to set the content and scope of re-education by a comparative analysis for the scores of the preliminary examination, which is comparable to the Korean Medical Licensing Examination (KMLE. Methods The scores of the first and second preliminary exams were analyzed by subject using the Wilcoxon signed rank test. The passing status of the group of NK doctors for KMLE in recent 3 years were investigated. The multiple-choice-question (MCQ items of which difficulty indexes of NK doctors were lower than those of South Korean (SK medical students by two times of the standard deviation of the scores of SK medical students were selected to investigate the relevant reasons. Results The average scores of nearly all subjects were improved in the second exam compared with the first exam. The passing rate of the group of NK doctors was 75%. The number of MCQ items of which difficulty indexes of NK doctors were lower than those of SK medical students was 51 (6.38%. NK doctors’ lack of understandings for Diagnostic Techniques and Procedures, Therapeutics, Prenatal Care, and Managed Care Programs was suggested as the possible reason. Conclusion The education of integrated courses focusing on Diagnostic Techniques and Procedures and Therapeutics, and apprenticeship-style training for clinical practice of core subjects are needed. Special lectures on the Preventive Medicine are likely to be required also.

  11. Counting SET-free sets

    OpenAIRE

    Harman, Nate

    2016-01-01

    We consider the following counting problem related to the card game SET: How many $k$-element SET-free sets are there in an $n$-dimensional SET deck? Through a series of algebraic reformulations and reinterpretations, we show the answer to this question satisfies two polynomiality conditions.

  12. A lock circuit for a multi-core processor

    DEFF Research Database (Denmark)

    2015-01-01

    An integrated circuit comprising a multiple processor cores and a lock circuit that comprises a queue register with respective bits set or reset via respective, connections dedicated to respective processor cores, whereby the queue register identifies those among the multiple processor cores...... that are enqueued in the queue register. Furthermore, the integrated circuit comprises a current register and a selector circuit configured to select a processor core and identify that processor core by a value in the current register. A selected processor core is a prioritized processor core among the cores...... configured with an integrated circuit; and a silicon die configured with an integrated circuit....

  13. Core principles of evolutionary medicine

    Science.gov (United States)

    Grunspan, Daniel Z; Nesse, Randolph M; Barnes, M Elizabeth; Brownell, Sara E

    2018-01-01

    Abstract Background and objectives Evolutionary medicine is a rapidly growing field that uses the principles of evolutionary biology to better understand, prevent and treat disease, and that uses studies of disease to advance basic knowledge in evolutionary biology. Over-arching principles of evolutionary medicine have been described in publications, but our study is the first to systematically elicit core principles from a diverse panel of experts in evolutionary medicine. These principles should be useful to advance recent recommendations made by The Association of American Medical Colleges and the Howard Hughes Medical Institute to make evolutionary thinking a core competency for pre-medical education. Methodology The Delphi method was used to elicit and validate a list of core principles for evolutionary medicine. The study included four surveys administered in sequence to 56 expert panelists. The initial open-ended survey created a list of possible core principles; the three subsequent surveys winnowed the list and assessed the accuracy and importance of each principle. Results Fourteen core principles elicited at least 80% of the panelists to agree or strongly agree that they were important core principles for evolutionary medicine. These principles over-lapped with concepts discussed in other articles discussing key concepts in evolutionary medicine. Conclusions and implications This set of core principles will be helpful for researchers and instructors in evolutionary medicine. We recommend that evolutionary medicine instructors use the list of core principles to construct learning goals. Evolutionary medicine is a young field, so this list of core principles will likely change as the field develops further. PMID:29493660

  14. Animal MRI Core

    Data.gov (United States)

    Federal Laboratory Consortium — The Animal Magnetic Resonance Imaging (MRI) Core develops and optimizes MRI methods for cardiovascular imaging of mice and rats. The Core provides imaging expertise,...

  15. Preliminary Study on the High Efficiency Supercritical Pressure Water-Cooled Reactor for Electricity Generation

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Yoon Yeong; Park, Jong Kyun; Cho, Bong Hyun and others

    2006-01-15

    This research has been performed to introduce a concept of supercritical pressure water cooled reactor(SCWR) in Korea The area of research includes core conceptual design, evaluation of candidate fuel, fluid systems conceptual design with mechanical consideration, preparation of safety analysis code, and construction of supercritical pressure heat transfer test facility, SPHINX, and preliminary test. As a result of the research, a set of tools for the reactor core design has been developed and the conceptual core design with solid moderator was proposed. The direct thermodynamic cycle has been studied to find a optimum design. The safety analysis code has also been adapted to supercritical pressure condition. A supercritical pressure CO2 heat transfer test facility has been constructed and preliminary test proved the facility works as expected. The result of this project will be good basis for the participation in the international collaboration under GIF GEN-IV program and next 5-year mid and long term nuclear research program of MOST. The heat transfer test loop, SPHINX, completed as a result of this project may be used for the power cycle study as well as further heat transfer study for the various geometries.

  16. Performance testing of a mixed TRIGA core

    Energy Technology Data Exchange (ETDEWEB)

    Schumacher, R F; Godsey, T A; Feltz, D E; Randall, J D [Texas A and M University (United States)

    1974-07-01

    The major operational problem experienced by the Nuclear Science Center Reactor at Texas A and M University is full burnup. With two shift operation caused by the high utilization of the facility, the reactor is operated more than 100 megawatt days per year. The solution chosen for this problem was conversion to FLIP fuel. Since funds were not available to load an entire FLIP core, a mixed core comprised of approximately one third FLIP fuel located in the central region was designed. The design core was loaded and went critical on July 1, 1973. The results of the following measurements on the mixed core are presented: Determination of Rod worths; Measurement of Reactivity Effects; Determination of Flux values; Measurement of Fuel temperatures; Preliminary Fuel Burnup Rate; Pulsing Calibration. (author)

  17. Conceptual Design of the RHIC Dump Core

    Energy Technology Data Exchange (ETDEWEB)

    Stevens, A. J. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    1995-09-26

    Conceptually, the internal dump consists of a "core" whose purpose is to absorb the energy of the beam, and surrounding shielding whose purpose is to attenuate radiation. Design of the core for an internal dump has two problems which must be overcome. The first problem is preserving the integrity of the dump core. The bunches must be dispersed laterally an amount sufficient to keep the energy density from cracking the dump core material. Since the dump kickers in RHIC are only ~25m upstream of the entrance face of the dump, this is i a difficult problem. The second problem, not addressed in this note, is that dumping the beam should not quench downstream magnets. Preliminary calculations related to both of these problems have been presented in earlier notes.

  18. Reactor-core-reactivity control device

    International Nuclear Information System (INIS)

    Miura, Teruo; Sakuranaga, Tomonobu.

    1983-01-01

    Purpose: To improve the reactor safety upon failures of control rod drives by adapting a control rod not to drop out accidentally from the reactor core but be inserted into the reactor core. Constitution: The control rod is entered or extracted as usual from the bottom of the pressure vessel. A space is provided above the reactor core within the pressure vessel, in which the moving scope of the control rod is set between the space above the reactor core and the reactor core. That is, the control rod is situated above the reactor core upon extraction thereof and, if an accident occurs to the control rod drive mechanisms to detach the control rod and the driving rod, the control rod falls gravitationally into the reactor core to improve the reactor safety. In addition, since the speed limiter is no more required to the control rod, the driving force can be decreased to reduce the size of the rod drive mechanisms. (Ikeda, J.)

  19. A PRELIMINARY JUPITER MODEL

    International Nuclear Information System (INIS)

    Hubbard, W. B.; Militzer, B.

    2016-01-01

    In anticipation of new observational results for Jupiter's axial moment of inertia and gravitational zonal harmonic coefficients from the forthcoming Juno orbiter, we present a number of preliminary Jupiter interior models. We combine results from ab initio computer simulations of hydrogen–helium mixtures, including immiscibility calculations, with a new nonperturbative calculation of Jupiter's zonal harmonic coefficients, to derive a self-consistent model for the planet's external gravity and moment of inertia. We assume helium rain modified the interior temperature and composition profiles. Our calculation predicts zonal harmonic values to which measurements can be compared. Although some models fit the observed (pre-Juno) second- and fourth-order zonal harmonics to within their error bars, our preferred reference model predicts a fourth-order zonal harmonic whose absolute value lies above the pre-Juno error bars. This model has a dense core of about 12 Earth masses and a hydrogen–helium-rich envelope with approximately three times solar metallicity

  20. A PRELIMINARY JUPITER MODEL

    Energy Technology Data Exchange (ETDEWEB)

    Hubbard, W. B. [Lunar and Planetary Laboratory, The University of Arizona, Tucson, AZ 85721 (United States); Militzer, B. [Department of Earth and Planetary Science, Department of Astronomy, University of California, Berkeley, CA 94720 (United States)

    2016-03-20

    In anticipation of new observational results for Jupiter's axial moment of inertia and gravitational zonal harmonic coefficients from the forthcoming Juno orbiter, we present a number of preliminary Jupiter interior models. We combine results from ab initio computer simulations of hydrogen–helium mixtures, including immiscibility calculations, with a new nonperturbative calculation of Jupiter's zonal harmonic coefficients, to derive a self-consistent model for the planet's external gravity and moment of inertia. We assume helium rain modified the interior temperature and composition profiles. Our calculation predicts zonal harmonic values to which measurements can be compared. Although some models fit the observed (pre-Juno) second- and fourth-order zonal harmonics to within their error bars, our preferred reference model predicts a fourth-order zonal harmonic whose absolute value lies above the pre-Juno error bars. This model has a dense core of about 12 Earth masses and a hydrogen–helium-rich envelope with approximately three times solar metallicity.

  1. Automatic sets and Delone sets

    International Nuclear Information System (INIS)

    Barbe, A; Haeseler, F von

    2004-01-01

    Automatic sets D part of Z m are characterized by having a finite number of decimations. They are equivalently generated by fixed points of certain substitution systems, or by certain finite automata. As examples, two-dimensional versions of the Thue-Morse, Baum-Sweet, Rudin-Shapiro and paperfolding sequences are presented. We give a necessary and sufficient condition for an automatic set D part of Z m to be a Delone set in R m . The result is then extended to automatic sets that are defined as fixed points of certain substitutions. The morphology of automatic sets is discussed by means of examples

  2. CCTF CORE I test results

    International Nuclear Information System (INIS)

    Murao, Yoshio; Sudoh, Takashi; Akimoto, Hajime; Iguchi, Tadashi; Sugimoto, Jun; Fujiki, Kazuo; Hirano, Kenmei

    1982-07-01

    This report presents the results of the following CCTF CORE I tests conducted in FY. 1980. (1) Multi-dimensional effect test, (2) Evaluation model test, (3) FLECHT coupling test. On the first test, one-dimensional treatment of the core thermohydrodynamics was discussed. On the second and third tests, the test results were compared with the results calculated by the evaluation model codes and the results of the corresponding FLECHT-SET test (Run 2714B), respectively. The work was performed under contracts with the Atomic Energy Bureau of Science and Technology Agency of Japan. (author)

  3. Bioinformatics and Computational Core Technology Center

    Data.gov (United States)

    Federal Laboratory Consortium — SERVICES PROVIDED BY THE COMPUTER CORE FACILITYEvaluation, purchase, set up, and maintenance of the computer hardware and network for the 170 users in the research...

  4. Preliminary Monthly Climatological Summaries

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Preliminary Local Climatological Data, recorded since 1970 on Weather Burean Form 1030 and then National Weather Service Form F-6. The preliminary climate data pages...

  5. Initial charge reactor core

    International Nuclear Information System (INIS)

    Kiyono, Takeshi

    1984-01-01

    Purpose: To effectivity burn fuels and improve the economical performance in an inital charge reactor core of BWR type reactors or the likes. Constitution: In a reactor core constituted with a plurality of fuel assemblies which are to be partially replaced upon fuel replacement, the density of the fissionable materials and the moderator - fuel ratio of a fuel assembly is set corresponding to the period till that fuel assembly is replaced, in which the density of the nuclear fissionable materials is lowered and the moderator - fuel ratio is increased for the fuel assembly with a shorter period from the fueling to the fuel exchange and, while on the other hand, the density of the fissionable materials is increased and the moderator - fuel ratio is decreased for the fuel assembly with a longer period from the fueling to the replacement. Accordingly, since the moderator - fuel ratio is increased for the fuel assembly to be replaced in a shorter period, the neutrons moderating effect is increased to increase the reactivity. (Horiuchi, T.)

  6. Early Dynamics of the Moon's Core

    Science.gov (United States)

    Cuk, Matija; Hamilton, Douglas; Stewart, Sarah T.

    2018-04-01

    The Moon has a small molten iron core (Williams et al. 2006). Remanent magnetization in lunar rocks likely derives from a past lunar dynamo (Wieczorek 2018 and references therein), which may have been powered by differential precession between the mantle and the core. The rotations of the lunar mantle and core were largely decoupled for much of lunar history, with a large mutual offset during the Cassini State Transition (Meyer and Wisdom, 2011). It is likely that the past work underestimated lunar obliquities, and therefore core offsets, during early lunar history (Cuk et al. 2016). Here we investigate the dynamics of the lunar core and mantle using a Lie-Poisson numerical integrator (Touma and Wisdom 2001) which includes interactions between triaxial core and mantle, as well as all gravitational and tidal effects included in the model of Cuk et al. (2016). Since we assume a rigid triaxial mantle, this model is applicable to the Moon only once it has acquired its current shape, which probably happened before the Moon reached 25 Earth radii. While some details of the core dynamics depend on our assumptions about the shape of the lunar core-mantle boundary, we can report some robust preliminary findings. The presence of the core does not change significantly the evolutionary scenario of Cuk et al. (2016). The core and mantle are indeed decoupled, with the core having a much smaller obliquity to the ecliptic than the mantle for almost all of the lunar history. The core was largely in an equivalent of Cassini State 2, with the vernal equinoxes (wrt the ecliptic) of the core and the mantle being anti-aligned. The core-mantle spin axis offset has been very large during the Moon's first billion years (this is true both in canonical and high-inclination tidal evolution), causing the lunar core to be sub-synchronous. If the ancient lunar magnetic dipole was rotating around the core axis that was inclined to the Moon's spin axis, then the magnetic poles would move across

  7. The CORE study protocol: a stepped wedge cluster randomised controlled trial to test a co-design technique to optimise psychosocial recovery outcomes for people affected by mental illness in the community mental health setting

    Science.gov (United States)

    Palmer, Victoria J; Chondros, Patty; Piper, Donella; Callander, Rosemary; Weavell, Wayne; Godbee, Kali; Potiriadis, Maria; Richard, Lauralie; Densely, Konstancja; Herrman, Helen; Furler, John; Pierce, David; Schuster, Tibor; Iedema, Rick; Gunn, Jane

    2015-01-01

    Introduction User engagement in mental health service design is heralded as integral to health systems quality and performance, but does engagement improve health outcomes? This article describes the CORE study protocol, a novel stepped wedge cluster randomised controlled trial (SWCRCT) to improve psychosocial recovery outcomes for people with severe mental illness. Methods An SWCRCT with a nested process evaluation will be conducted over nearly 4 years in Victoria, Australia. 11 teams from four mental health service providers will be randomly allocated to one of three dates 9 months apart to start the intervention. The intervention, a modified version of Mental Health Experience Co-Design (MH ECO), will be delivered to 30 service users, 30 carers and 10 staff in each cluster. Outcome data will be collected at baseline (6 months) and at completion of each intervention wave. The primary outcome is improvement in recovery score using the 24-item Revised Recovery Assessment Scale for service users. Secondary outcomes are improvements to user and carer mental health and well-being using the shortened 8-item version of the WHOQOL Quality of Life scale (EUROHIS), changes to staff attitudes using the 19-item Staff Attitudes to Recovery Scale and recovery orientation of services using the 36-item Recovery Self Assessment Scale (provider version). Intervention and usual care periods will be compared using a linear mixed effects model for continuous outcomes and a generalised linear mixed effects model for binary outcomes. Participants will be analysed in the group that the cluster was assigned to at each time point. Ethics and dissemination The University of Melbourne, Human Research Ethics Committee (1340299.3) and the Federal and State Departments of Health Committees (Project 20/2014) granted ethics approval. Baseline data results will be reported in 2015 and outcomes data in 2017. Trial registration number Australian and New Zealand Clinical Trials Registry ACTRN

  8. Aircraft Research Guideline 1999 - 2002: High pressure compressor - preliminary design as a basis for the development of an efficient and environmentally friendly core engine. Final report; Leitlinie Luftfahrtforschung 1999 - 2002: Hochdruckverdichter-Vorauslegung als Grundlagenuntersuchung zur Entwicklung eines Kerntriebwerkes fuer einen effizienten und umweltfreundlichen Antrieb. Schlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Klinger, H.

    2001-08-01

    This report completes the documentation for the research project 'High Pressure Compressor - Preliminary Design as Basis for the Development of an Efficient and Environmentally Friendly Core Engine' which was funded by the Ministry of Economics of State Brandenburg. The objective of the project is to deliver a preliminary compressor aerodynamic design as well as design studies for an efficient, weight and cost improved compressor. The increase of stage pressure ratio and improved efficiency, whilst stage and blade count is reduced, has been achieved by advanced 3D methods. Compressor stability also at off-design conditions will be retained. The mechanical design focusses on a cost and weight optimised rotor not only for a conventional bladed discs but also for Blish stages. Various options for split casings have been developed and assessed. Alternative vortex reducers based on different design options have been carried out. The results from this project will be directly exploited in a follow-on project for a new nine-stage compressor. The new high pressure compressor will be a key element of the future two-shaft-engine architecture. (orig.) [German] Der vorliegende Bericht schliesst das vom Land Brandenburg im Rahmen der Leitlinie Luftfahrtforschung gefoerderte Vorhaben 'Hochdruckverdichter - Vorauslegung als Grundlagenuntersuchung zur Entwicklung eines Kerntriebwerkes fuer einen effizienten und umweltfreundlichen Antrieb' ab. Ziel dieses Vorhabens ist es, im Rahmen einer aerodynamischen Vorauslegung sowie Designstudien die notwendigen Technologien zu erarbeiten, um einen hinsichtlich Effizienz, Kosten, Gewicht und Wartungsintervallen verbesserten Hochdruckverdichter auszulegen. Die Erhoehung des Druckverhaeltnisses und des Wirkungsgrads bei verringerter Stufen- und Schaufelzahl sowie ein stabiles Betriebsverhalten auch ausserhalb des Auslegungspunktes wurde dabei durch eine aeusserst fortschrittliche 3D Schaufelauslegung erreicht. Auf der

  9. TMI-2 core-examination program: INEL facilities readiness study

    International Nuclear Information System (INIS)

    McLaughlin, T.B.

    1983-02-01

    This report reviews the capability and readiness of remote handling facilities at the Idaho National Engineering Laboratory (INEL) to receive, and store the TMI-2 core, and to examine and analyze TMI-2 core samples. To accomplish these objectives, the facilities must be able to receive commercial casks, unload canisters from the casks, store the canisters, open the canisters, handle the fuel debris and assemblies, and perform various examinations. The report identifies documentation, including core information, necessary to INEL before receiving the entire TMI-2 core. Also identified are prerequisites to INEL's receipt of the first canister: costs, schedules, and a preliminary project plan for the tasks

  10. Core Hunter 3: flexible core subset selection.

    Science.gov (United States)

    De Beukelaer, Herman; Davenport, Guy F; Fack, Veerle

    2018-05-31

    Core collections provide genebank curators and plant breeders a way to reduce size of their collections and populations, while minimizing impact on genetic diversity and allele frequency. Many methods have been proposed to generate core collections, often using distance metrics to quantify the similarity of two accessions, based on genetic marker data or phenotypic traits. Core Hunter is a multi-purpose core subset selection tool that uses local search algorithms to generate subsets relying on one or more metrics, including several distance metrics and allelic richness. In version 3 of Core Hunter (CH3) we have incorporated two new, improved methods for summarizing distances to quantify diversity or representativeness of the core collection. A comparison of CH3 and Core Hunter 2 (CH2) showed that these new metrics can be effectively optimized with less complex algorithms, as compared to those used in CH2. CH3 is more effective at maximizing the improved diversity metric than CH2, still ensures a high average and minimum distance, and is faster for large datasets. Using CH3, a simple stochastic hill-climber is able to find highly diverse core collections, and the more advanced parallel tempering algorithm further increases the quality of the core and further reduces variability across independent samples. We also evaluate the ability of CH3 to simultaneously maximize diversity, and either representativeness or allelic richness, and compare the results with those of the GDOpt and SimEli methods. CH3 can sample equally representative cores as GDOpt, which was specifically designed for this purpose, and is able to construct cores that are simultaneously more diverse, and either are more representative or have higher allelic richness, than those obtained by SimEli. In version 3, Core Hunter has been updated to include two new core subset selection metrics that construct cores for representativeness or diversity, with improved performance. It combines and outperforms the

  11. The CORE study protocol: a stepped wedge cluster randomised controlled trial to test a co-design technique to optimise psychosocial recovery outcomes for people affected by mental illness in the community mental health setting.

    Science.gov (United States)

    Palmer, Victoria J; Chondros, Patty; Piper, Donella; Callander, Rosemary; Weavell, Wayne; Godbee, Kali; Potiriadis, Maria; Richard, Lauralie; Densely, Konstancja; Herrman, Helen; Furler, John; Pierce, David; Schuster, Tibor; Iedema, Rick; Gunn, Jane

    2015-03-24

    User engagement in mental health service design is heralded as integral to health systems quality and performance, but does engagement improve health outcomes? This article describes the CORE study protocol, a novel stepped wedge cluster randomised controlled trial (SWCRCT) to improve psychosocial recovery outcomes for people with severe mental illness. An SWCRCT with a nested process evaluation will be conducted over nearly 4 years in Victoria, Australia. 11 teams from four mental health service providers will be randomly allocated to one of three dates 9 months apart to start the intervention. The intervention, a modified version of Mental Health Experience Co-Design (MH ECO), will be delivered to 30 service users, 30 carers and 10 staff in each cluster. Outcome data will be collected at baseline (6 months) and at completion of each intervention wave. The primary outcome is improvement in recovery score using the 24-item Revised Recovery Assessment Scale for service users. Secondary outcomes are improvements to user and carer mental health and well-being using the shortened 8-item version of the WHOQOL Quality of Life scale (EUROHIS), changes to staff attitudes using the 19-item Staff Attitudes to Recovery Scale and recovery orientation of services using the 36-item Recovery Self Assessment Scale (provider version). Intervention and usual care periods will be compared using a linear mixed effects model for continuous outcomes and a generalised linear mixed effects model for binary outcomes. Participants will be analysed in the group that the cluster was assigned to at each time point. The University of Melbourne, Human Research Ethics Committee (1340299.3) and the Federal and State Departments of Health Committees (Project 20/2014) granted ethics approval. Baseline data results will be reported in 2015 and outcomes data in 2017. Australian and New Zealand Clinical Trials Registry ACTRN12614000457640. Published by the BMJ Publishing Group Limited. For

  12. Grain alignment in starless cores

    International Nuclear Information System (INIS)

    Jones, T. J.; Bagley, M.; Krejny, M.; Andersson, B.-G.; Bastien, P.

    2015-01-01

    We present near-IR polarimetry data of background stars shining through a selection of starless cores taken in the K band, probing visual extinctions up to A V ∼48. We find that P K /τ K continues to decline with increasing A V with a power law slope of roughly −0.5. Examination of published submillimeter (submm) polarimetry of starless cores suggests that by A V ≳20 the slope for P versus τ becomes ∼−1, indicating no grain alignment at greater optical depths. Combining these two data sets, we find good evidence that, in the absence of a central illuminating source, the dust grains in dense molecular cloud cores with no internal radiation source cease to become aligned with the local magnetic field at optical depths greater than A V ∼20. A simple model relating the alignment efficiency to the optical depth into the cloud reproduces the observations well.

  13. Temporal Change of Seismic Earth's Inner Core Phases: Inner Core Differential Rotation Or Temporal Change of Inner Core Surface?

    Science.gov (United States)

    Yao, J.; Tian, D.; Sun, L.; Wen, L.

    2017-12-01

    Since Song and Richards [1996] first reported seismic evidence for temporal change of PKIKP wave (a compressional wave refracted in the inner core) and proposed inner core differential rotation as its explanation, it has generated enormous interests in the scientific community and the public, and has motivated many studies on the implications of the inner core differential rotation. However, since Wen [2006] reported seismic evidence for temporal change of PKiKP wave (a compressional wave reflected from the inner core boundary) that requires temporal change of inner core surface, both interpretations for the temporal change of inner core phases have existed, i.e., inner core rotation and temporal change of inner core surface. In this study, we discuss the issue of the interpretation of the observed temporal changes of those inner core phases and conclude that inner core differential rotation is not only not required but also in contradiction with three lines of seismic evidence from global repeating earthquakes. Firstly, inner core differential rotation provides an implausible explanation for a disappearing inner core scatterer between a doublet in South Sandwich Islands (SSI), which is located to be beneath northern Brazil based on PKIKP and PKiKP coda waves of the earlier event of the doublet. Secondly, temporal change of PKIKP and its coda waves among a cluster in SSI is inconsistent with the interpretation of inner core differential rotation, with one set of the data requiring inner core rotation and the other requiring non-rotation. Thirdly, it's not reasonable to invoke inner core differential rotation to explain travel time change of PKiKP waves in a very small time scale (several months), which is observed for repeating earthquakes in Middle America subduction zone. On the other hand, temporal change of inner core surface could provide a consistent explanation for all the observed temporal changes of PKIKP and PKiKP and their coda waves. We conclude that

  14. Microstructural Location and Composition of Impurities in Polar Ice Cores, Version 1

    Data.gov (United States)

    National Aeronautics and Space Administration — This data set contains measurements of impurities and ions in three polar ice cores: the Vostok 5G ice core and the Byrd ice core from Antarctica, and the Greenland...

  15. k-core covers and the core

    NARCIS (Netherlands)

    Sanchez-Rodriguez, E.; Borm, Peter; Estevez-Fernandez, A.; Fiestras-Janeiro, G.; Mosquera, M.A.

    This paper extends the notion of individual minimal rights for a transferable utility game (TU-game) to coalitional minimal rights using minimal balanced families of a specific type, thus defining a corresponding minimal rights game. It is shown that the core of a TU-game coincides with the core of

  16. Core body temperature in obesity123

    Science.gov (United States)

    Heikens, Marc J; Gorbach, Alexander M; Eden, Henry S; Savastano, David M; Chen, Kong Y; Skarulis, Monica C

    2011-01-01

    Background: A lower core body temperature set point has been suggested to be a factor that could potentially predispose humans to develop obesity. Objective: We tested the hypothesis that obese individuals have lower core temperatures than those in normal-weight individuals. Design: In study 1, nonobese [body mass index (BMI; in kg/m2) <30] and obese (BMI ≥30) adults swallowed wireless core temperature–sensing capsules, and we measured core temperatures continuously for 24 h. In study 2, normal-weight (BMI of 18–25) and obese subjects swallowed temperature-sensing capsules to measure core temperatures continuously for ≥48 h and kept activity logs. We constructed daily, 24-h core temperature profiles for analysis. Results: Mean (±SE) daily core body temperature did not differ significantly between the 35 nonobese and 46 obese subjects (36.92 ± 0.03°C compared with 36.89 ± 0.03°C; P = 0.44). Core temperature 24-h profiles did not differ significantly between 11 normal-weight and 19 obese subjects (P = 0.274). Women had a mean core body temperature ≈0.23°C greater than that of men (36.99 ± 0.03°C compared with 36.76 ± 0.03°C; P < 0.0001). Conclusions: Obesity is not generally associated with a reduced core body temperature. It may be necessary to study individuals with function-altering mutations in core temperature–regulating genes to determine whether differences in the core body temperature set point affect the regulation of human body weight. These trials were registered at clinicaltrials.gov as NCT00428987 and NCT00266500. PMID:21367952

  17. Reactor core fuel management

    International Nuclear Information System (INIS)

    Silvennoinen, P.

    1976-01-01

    The subject is covered in chapters, entitled: concepts of reactor physics; neutron diffusion; core heat transfer; reactivity; reactor operation; variables of core management; computer code modules; alternative reactor concepts; methods of optimization; general system aspects. (U.K.)

  18. Nuclear reactor core catcher

    International Nuclear Information System (INIS)

    1977-01-01

    A nuclear reactor core catcher is described for containing debris resulting from an accident causing core meltdown and which incorporates a method of cooling the debris by the circulation of a liquid coolant. (U.K.)

  19. Core Design Concept and Core Structural Material Development for a Prototype SFR

    International Nuclear Information System (INIS)

    Chang, Jinwook

    2013-01-01

    Core design Concept: – Initial core is Uranium metal fueled core, then it will evolve into TRU core; – Tight pressure drop constraint lowers power density; – Trade-off studies with relaxed pressure drop constraint (~0.4MPa) are on-going; – Major feature will be finalized this year. • KAERI is developing advanced cladding for high burnup fuel in Ptototype SFR: – Advanced cladding materials are now developing, which shows superior high temperature mechanical property to the conventional material; – Processing technologies related to tube making process are now developed to enhance high temperature mechanical propertyl – Preliminary HT9 cladding tube was manufactured and out-of pile mechanical properties were evaluated. Advanced cladding tube is now being developed and being prepared for irradiation test

  20. Seismic core shroud

    International Nuclear Information System (INIS)

    Puri, A.; Mullooly, J.F.

    1981-01-01

    A core shroud is provided, comprising: a coolant boundary, following the shape of the core boundary, for channeling the coolant through the fuel assemblies; a cylindrical band positioned inside the core barrel and surrounding the coolant boundary; and support members extending from the coolant boundary to the band, for transferring load from the coolant boundary to the band. The shroud may be assembled in parts using automated welding techniques, and it may be adjusted to fit the reactor core easily

  1. Seismic Wave Velocity in Earth's Shallow Core

    Science.gov (United States)

    Alexandrakis, C.; Eaton, D. W.

    2008-12-01

    Studies of the outer core indicate that it is composed of liquid Fe and Ni alloyed with a ~10% fraction of light elements such as O, S or Si. Recently, unusual features, such as sediment accumulation, immiscible fluid layers or stagnant convection, have been predicted in the shallow core region. Secular cooling and compositional buoyancy drive vigorous convection that sustains the geodynamo, although critical details of light-element composition and thermal regime remain uncertain. Seismic velocity models can provide important constraints on the light element composition, however global reference models, such as Preliminary Reference Earth Model (PREM), IASP91 and AK135 vary significantly in the 200 km below the core-mantle boundary. Past studies of the outermost core velocity structure have been hampered by traveltime uncertainties due to lowermost mantle heterogeneities. The recently published Empirical Transfer Function (ETF) method has been shown to reduce the uncertainty using a waveform stacking approach to improve global observations of SmKS teleseismic waves. Here, we apply the ETF method to achieve a precise top-of-core velocity measurement of 8.05 ± 0.03 km/s. This new model accords well with PREM. Since PREM is based on the adiabatic form of the Adams-Williamson equation, it assumes a well mixed (i.e. homogeneous) composition. This result suggests a lack of heterogeneity in the outermost core due to layering or stagnant convection.

  2. Preliminary Report on Unique Laminated Holocene Sediments from the Qarun Lake in Egypt

    Directory of Open Access Journals (Sweden)

    Marks Leszek

    2016-06-01

    Full Text Available The Lake Qarun (Faiyum Oasis, northern Egypt is a relic of the much larger Holocene lake. Past lake levels and extensions were reconstructed, based on setting of archaeological sites scattered along northern paleoshores of the ancient lake. However, geoarcheological works did not yield enough data to establish continuous environmental history of the lake. A deep drilling FA-1 on the southeastern shore of the lake, performed in 2014, supplied with a core, 26 m long that is the one of the longest lake sediment cores in northeastern Africa. The basal section of the core consisted of thin-laminated diatom marly deposits, underlain at the Late Pleistocene/Holocene boundary by coarse-grained sands. The sediment lamine were quite well developed, especially in the lower part of the core. Preliminary results indicated annually deposited sediment sequence with seasonality signals provided by microlamine of diatoms, calcite, organic matter and clastic material. Early Holocene varved sediments from the Faiyum Oasis supplied with exceptional paleoenvironmental data for northeastern Africa, which enriched a record from previous logs drilled at the southwestern margin of the Qarun Lake.

  3. Core Values | NREL

    Science.gov (United States)

    Core Values Core Values NREL's core values are rooted in a safe and supportive work environment guide our everyday actions and efforts: Safe and supportive work environment Respect for the rights physical and social environment Integrity Maintain the highest standard of ethics, honesty, and integrity

  4. Sidewall coring shell

    Energy Technology Data Exchange (ETDEWEB)

    Edelman, Ya A; Konstantinov, L P; Martyshin, A N

    1966-12-12

    A sidewall coring shell consists of a housing and a detachable core catcher. The core lifter is provided with projections, the ends of which are situated in another plane, along the longitudinal axis of the lifter. The chamber has corresponding projections.

  5. Computer-Aided Test Flow in Core-Based Design

    NARCIS (Netherlands)

    Zivkovic, V.; Tangelder, R.J.W.T.; Kerkhoff, Hans G.

    2000-01-01

    This paper copes with the efficient test-pattern generation in a core-based design. A consistent Computer-Aided Test (CAT) flow is proposed based on the required core-test strategy. It generates a test-pattern set for the embedded cores with high fault coverage and low DfT area overhead. The CAT

  6. Rotary core drills

    Energy Technology Data Exchange (ETDEWEB)

    1967-11-30

    The design of a rotary core drill is described. Primary consideration is given to the following component parts of the drill: the inner and outer tube, the core bit, an adapter, and the core lifter. The adapter has the form of a downward-converging sleeve and is mounted to the lower end of the inner tube. The lifter, extending from the adapter, is split along each side so that it can be held open to permit movement of a core. It is possible to grip a core by allowing the lifter to assume a closed position.

  7. Identifying ELIXIR Core Data Resources.

    Science.gov (United States)

    Durinx, Christine; McEntyre, Jo; Appel, Ron; Apweiler, Rolf; Barlow, Mary; Blomberg, Niklas; Cook, Chuck; Gasteiger, Elisabeth; Kim, Jee-Hyub; Lopez, Rodrigo; Redaschi, Nicole; Stockinger, Heinz; Teixeira, Daniel; Valencia, Alfonso

    2016-01-01

    The core mission of ELIXIR is to build a stable and sustainable infrastructure for biological information across Europe. At the heart of this are the data resources, tools and services that ELIXIR offers to the life-sciences community, providing stable and sustainable access to biological data. ELIXIR aims to ensure that these resources are available long-term and that the life-cycles of these resources are managed such that they support the scientific needs of the life-sciences, including biological research. ELIXIR Core Data Resources are defined as a set of European data resources that are of fundamental importance to the wider life-science community and the long-term preservation of biological data. They are complete collections of generic value to life-science, are considered an authority in their field with respect to one or more characteristics, and show high levels of scientific quality and service. Thus, ELIXIR Core Data Resources are of wide applicability and usage. This paper describes the structures, governance and processes that support the identification and evaluation of ELIXIR Core Data Resources. It identifies key indicators which reflect the essence of the definition of an ELIXIR Core Data Resource and support the promotion of excellence in resource development and operation. It describes the specific indicators in more detail and explains their application within ELIXIR's sustainability strategy and science policy actions, and in capacity building, life-cycle management and technical actions. The identification process is currently being implemented and tested for the first time. The findings and outcome will be evaluated by the ELIXIR Scientific Advisory Board in March 2017. Establishing the portfolio of ELIXIR Core Data Resources and ELIXIR Services is a key priority for ELIXIR and publicly marks the transition towards a cohesive infrastructure.

  8. Preliminary neutronic design of spock reactor: A nuclear system for space power generation

    International Nuclear Information System (INIS)

    Burgio, N.; Santagata, A.; Cumo, M.; Fasano, A.; Frullini, M.

    2007-01-01

    Aim of this paper is to preliminary investigates the neutronic features of an upgrade of the MAUS [1] nuclear reactor whose core will be able to supply a thermoelectric converter in order to generate 30 kW of electricity for space applications. The neutronic layout of SPOCK (Space Power Core Ka) is a compact, MOX fuelled, liquid metal cooled and totally reflected fast reactor with a control system based on neutron absorption. Spock, that during the heart and launch operation must be maintained in sub-critical state, has to start up in the outer space at 40 K temperatures with the coolant in a solid state and it will reach the operating steady condition at the maximum temperature of 1300 K with the coolant in the liquid state. The main design goal is to maintains, in the operating conditions of a typical space mission, the control of the appropriate criticality margin versus temperature and coolant physical state. For this purpose, a neutronic/thermal-hydraulic calculation chain able to assists the entire design process must be set up. As preliminary recognition, MCNPX 2.5.0 and FLUENT calculations were carried out. The emerging key features of SPOCK are: an equilateral triangular mesh of 91 cylindrical UO 2 fuel rods with a Molybdenum clad ensured by two grids of the same material, cooled by liquid Sodium and contained in an AISI 316 L vessel. The core is totally wrapped by a Beryllium reflector that hosts six absorber (B 4 C) rotating control rods. The reactor shape is cylindrical (radius = 30 cm and height = 60 cm) with a total mass of 275 kg. The excess reactivity was of 5000 PCM at 1300 K. A preliminary evaluation of the control rods worth and a power spatial distribution were also discussed. Through the definition of an ideal reference K e ff value at 300 K for the actual SPOCK configuration, a sensitivity analysis on various cross sections data and material physical properties was performed for the given mission temperature range, allowing consideration on

  9. HYDRATE CORE DRILLING TESTS

    Energy Technology Data Exchange (ETDEWEB)

    John H. Cohen; Thomas E. Williams; Ali G. Kadaster; Bill V. Liddell

    2002-11-01

    The ''Methane Hydrate Production from Alaskan Permafrost'' project is a three-year endeavor being conducted by Maurer Technology Inc. (MTI), Noble, and Anadarko Petroleum, in partnership with the U.S. DOE National Energy Technology Laboratory (NETL). The project's goal is to build on previous and ongoing R&D in the area of onshore hydrate deposition. The project team plans to design and implement a program to safely and economically drill, core and produce gas from arctic hydrates. The current work scope includes drilling and coring one well on Anadarko leases in FY 2003 during the winter drilling season. A specially built on-site core analysis laboratory will be used to determine some of the physical characteristics of the hydrates and surrounding rock. Prior to going to the field, the project team designed and conducted a controlled series of coring tests for simulating coring of hydrate formations. A variety of equipment and procedures were tested and modified to develop a practical solution for this special application. This Topical Report summarizes these coring tests. A special facility was designed and installed at MTI's Drilling Research Center (DRC) in Houston and used to conduct coring tests. Equipment and procedures were tested by cutting cores from frozen mixtures of sand and water supported by casing and designed to simulate hydrate formations. Tests were conducted with chilled drilling fluids. Tests showed that frozen core can be washed out and reduced in size by the action of the drilling fluid. Washing of the core by the drilling fluid caused a reduction in core diameter, making core recovery very difficult (if not impossible). One successful solution was to drill the last 6 inches of core dry (without fluid circulation). These tests demonstrated that it will be difficult to capture core when drilling in permafrost or hydrates without implementing certain safeguards. Among the coring tests was a simulated hydrate

  10. Emergency core cooling system

    International Nuclear Information System (INIS)

    Sato, Akira; Kobayashi, Masahide.

    1983-01-01

    Purpose: To enable a stable operation of an emergency core cooling system by preventing the system from the automatic stopping at an abnormally high level of the reactor water during its operation. Constitution: A pump flow rate signal and a reactor water level signal are used and, when the reactor water level is increased to a predetermined level, the pump flow rate is controlled by the reactor water level signal instead of the flow rate signal. Specifically, when the reactor water level is gradually increased by the water injection from the pump and exceeds a setting signal for the water level, the water level deviation signal acts as a demand signal for the decrease in the flow rate of the pump and the output signal from the water level controller is also decreased depending on the control constant. At a certain point, the output signal from the water level controller becomes smaller than the output signal from the flow rate controller. Thus, the output signal from the water level controller is outputted as the output signal for the lower level preference device. In this way, the reactor water level and the pump flow rate can be controlled within a range not exceeding the predetermined pump flow rate. (Horiuchi, T.)

  11. Design of a PWR emergency core cooling simulator loop

    International Nuclear Information System (INIS)

    Melo, C.A. de.

    1982-12-01

    The preliminary design of a PWR Emergency Core Cooling Simulator Loop for investigations of the phenomena involved in a postulated Loss-of-Coolant Accident, during the Reflooding Phase, is presented. The functions of each component of the loop, the design methods and calculations, the specification of the instrumentation, the system operation sequence, the materials list and a cost assessment are included. (Author) [pt

  12. Test plan for core drilling ignitability testing

    International Nuclear Information System (INIS)

    Witwer, K.S.

    1996-01-01

    The objective of this testing is to determine if ignition occurs while core drilling in a flammable gas environment. Drilling parameters are chosen so as to provide bounding conditions for the core sampling environment. If ignition does not occur under the conditions set forth in this test, then a satisfactory level of confidence will be obtained which would allow field operations under the normal drilling conditions

  13. Language Core Values in a Multicultural Setting: An Australian Experience.

    Science.gov (United States)

    Smolicz, Jerzy J.

    1991-01-01

    Reviews European Community and Australian language policies. Considers cultural-economic interface in Australia with respect to current interest in teaching Asian languages for trade purposes. Discusses Australia's growing acceptance of languages other than English and its affect on Aboriginal people. Urges the better utilization of the country's…

  14. Gaspe hole sets depth record

    Energy Technology Data Exchange (ETDEWEB)

    1970-03-09

    The deepest diamond-cored hole in the Western Hemisphere, Gulf Sunnybank No. 1 on the Gaspe Peninsula of Quebec, has been completed at a depth of 11,600 ft. This is the deepest cored hole to be drilled anywhere in search of oil and gas production, and the deepest to be drilled using a wire-line core recovery technique. The well was completed in 183 days, and was cored continuously below the surface casing which was set and cemented at 1,004 ft. After underreaming a portion of the bottom of the hole, intermediate casing was set and cemented at 8,000 ft as a safety precaution against possible high oil or gas-fluid pressure. Actual coring time, after deducting time for underreaming and casing operations, was 152 days. Because of the cost of transporting a conventional oil-drilling rig to the E. location, the 89-ft mining rig was modified for the project. The contractor was Heath and Sherwood Drilling (Western) Ltd.

  15. Nonlinear core deflection in injection molding

    Science.gov (United States)

    Poungthong, P.; Giacomin, A. J.; Saengow, C.; Kolitawong, C.; Liao, H.-C.; Tseng, S.-C.

    2018-05-01

    Injection molding of thin slender parts is often complicated by core deflection. This deflection is caused by molten plastics race tracking through the slit between the core and the rigid cavity wall. The pressure of this liquid exerts a lateral force of the slender core causing the core to bend, and this bending is governed by a nonlinear fifth order ordinary differential equation for the deflection that is not directly in the position along the core. Here we subject this differential equation to 6 sets of boundary conditions, corresponding to 6 commercial core constraints. For each such set of boundary conditions, we develop an explicit approximate analytical solution, including both a linear term and a nonlinear term. By comparison with finite difference solutions, we find our new analytical solutions to be accurate. We then use these solutions to derive explicit analytical approximations for maximum deflections and for the core position of these maximum deflections. Our experiments on the base-gated free-tip boundary condition agree closely with our new explicit approximate analytical solution.

  16. The core paradox.

    Science.gov (United States)

    Kennedy, G. C.; Higgins, G. H.

    1973-01-01

    Rebuttal of suggestions from various critics attempting to provide an escape from the seeming paradox originated by Higgins and Kennedy's (1971) proposed possibility that the liquid in the outer core was thermally stably stratified and that this stratification might prove a powerful inhibitor to circulation of the outer core fluid of the kind postulated for the generation of the earth's magnetic field. These suggestions are examined and shown to provide no reasonable escape from the core paradox.

  17. Nuclear reactor core flow baffling

    International Nuclear Information System (INIS)

    Berringer, R.T.

    1979-01-01

    A flow baffling arrangement is disclosed for the core of a nuclear reactor. A plurality of core formers are aligned with the grids of the core fuel assemblies such that the high pressure drop areas in the core are at the same elevations as the high pressure drop areas about the core periphery. The arrangement minimizes core bypass flow, maintains cooling of the structure surrounding the core, and allows the utilization of alternative beneficial components such as neutron reflectors positioned near the core

  18. Quantum Physics Principles and Communication in the Acute Healthcare Setting: A Pilot Study.

    Science.gov (United States)

    Helgeson, Heidi L; Peyerl, Colleen Kraft; Solheim-Witt, Marit

    This pilot study explores whether clinician awareness of quantum physics principles could facilitate open communication between patients and providers. In the spirit of action research, this study was conceptualized with a holistic view of human health, using a mixed method design of grounded theory as an emergent method. Instrumentation includes surveys and a focus group discussion with twelve registered nurses working in an acute care hospital setting. Findings document that the preliminary core phenomenon, energy as information, influences communication in the healthcare environment. Key emergent themes include awareness, language, validation, open communication, strategies, coherence, incoherence and power. Research participants indicate that quantum physics principles provide a language and conceptual framework for improving their awareness of communication and interactions in the healthcare environment. Implications of this pilot study support the feasibility of future research and education on awareness of quantum physics principles in other clinical settings. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. Sediment Core Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — FUNCTION: Provides instrumentation and expertise for physical and geoacoustic characterization of marine sediments.DESCRIPTION: The multisensor core logger measures...

  20. A review of the core catcher design in LMR

    International Nuclear Information System (INIS)

    Lee, Yong Bum; Hahn, Do Hee

    2001-08-01

    The overwhelming emphasis in reactor safety is on the prevention of core meltdown. Moreover, although there have been several accidents that have resulted in some fuel melting, to date there have been no accidents severe enough to cause the syndrome of core collapse, reactor vessel melt-through, containment penetration, and dispersal into the ground. Nevertheless, a number of proposals have been made for the design of core catcher systems to control or stop the motion of the molten core mass should such an accident take place. Core catchers may differ in both their location within the reactor system and in the mechanism that is used to cool and control the motion of the core debris. In this report the classification, configuration and main features of the core catcher are described. And also, The core catcher design technologies and processes are presented. Finally the core catcher provisions in constructed and planned LMRs (Liquid Metal Reactors) are summarized and the preliminary assessment on the core catcher installation in KALIMER is presented

  1. Can Psychiatric Rehabilitation Be Core to CORE?

    Science.gov (United States)

    Olney, Marjorie F.; Gill, Kenneth J.

    2016-01-01

    Purpose: In this article, we seek to determine whether psychiatric rehabilitation principles and practices have been more fully incorporated into the Council on Rehabilitation Education (CORE) standards, the extent to which they are covered in four rehabilitation counseling "foundations" textbooks, and how they are reflected in the…

  2. Preliminary risk assessments of the small HTGR

    International Nuclear Information System (INIS)

    Everline, C.J.; Bellis, E.A.

    1985-05-01

    Preliminary investment and safety risk assessments were performed for a preconceptual design of a four-module 250-MW(t) side-by-side steel-vessel pebble bed HTGR plant. Broad event spectra were analyzed involving component damage resulting in unscheduled plant outages and fission product releases resulting in offsite doses. The preliminary assessment indicates at this stage of the design that two categories of events govern the investment risk envelope: primary coolant leaks which release some circulating and plate-out activity that contaminates the confinement and turbogenerator damage which involves extensive turbine blade failure. Primary coolant leaks are important contributors because associated cleanup and decontamination requirements result in longer outages that arise from other events with comparable frequencies. Turbogenerator damage is the salient low-frequency investment risk accident due to the relatively long outages being experienced in the industry. Thermal transients are unimportant investment risk contributors because pressurized core heatups cause little damage, and depressurized core heatups occur at negligible frequencies relative to the forced outage goal. These preliminary results demonstrate investment and safety risk goal compliance at this stage in the design process. Studies are continuing in order to provide valuable insights into risk-significant events to assure a balanced approach to meeting user and regulatory requirements

  3. DENSE MOLECULAR CORES BEING EXTERNALLY HEATED

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Gwanjeong; Lee, Chang Won; Kim, Mi-Ryang [Radio Astronomy division, Korea Astronomy and Space Science Institute, 776 Daedeokdae-ro, Yuseong-gu, Daejeon, 34055 (Korea, Republic of); Gopinathan, Maheswar [Aryabhatta Research Institute of Observational Sciences, Manora Peak, Nainital 263129 (India); Jeong, Woong-Seob, E-mail: archer81@kasi.re.kr [Department of Astronomy and Space Science, University of Science and Technology, 217 Gajungro, Yuseong-gu, Daejeon, 34113 (Korea, Republic of)

    2016-06-20

    We present results of our study of eight dense cores, previously classified as starless, using infrared (3–160 μ m) imaging observations with the AKARI telescope and molecular line (HCN and N{sub 2}H{sup +}) mapping observations with the KVN telescope. Combining our results with the archival IR to millimeter continuum data, we examined the starless nature of these eight cores. Two of the eight cores are found to harbor faint protostars having luminosities of ∼0.3–4.4 L {sub ⊙}. The other six cores are found to remain starless and probably are in a dynamically transitional state. The temperature maps produced using multi-wavelength images show an enhancement of about 3–6 K toward the outer boundary of these cores, suggesting that they are most likely being heated externally by nearby stars and/or interstellar radiation fields. Large virial parameters and an overdominance of red asymmetric line profiles over the cores may indicate that the cores are set into either an expansion or an oscillatory motion, probably due to the external heating. Most of the starless cores show a coreshine effect due to the scattering of light by the micron-sized dust grains. This may imply that the age of the cores is of the order of ∼10{sup 5} years, which is consistent with the timescale required for the cores to evolve into an oscillatory stage due to external perturbation. Our observational results support the idea that the external feedback from nearby stars and/or interstellar radiation fields may play an important role in the dynamical evolution of the cores.

  4. The AVRDC - The World Vegetable Center mungbean (Vigna radiata) core and mini core collections.

    Science.gov (United States)

    Schafleitner, Roland; Nair, Ramakrishnan Madhavan; Rathore, Abhishek; Wang, Yen-wei; Lin, Chen-yu; Chu, Shu-hui; Lin, Pin-yun; Chang, Jian-Cheng; Ebert, Andreas W

    2015-04-29

    Large ex situ germplasm collections generally harbor a wide range of crop diversity. AVRDC--The World Vegetable Center is holding in trust the world's second largest mungbean (Vigna radiata) germplasm collection with more than 6,700 accessions. Screening large collections for traits of interest is laborious and expensive. To enhance the access of breeders to the diversity of the crop, mungbean core and mini core collections have been established. The core collection of 1,481 entries has been built by random selection of 20% of the accessions after geographical stratification and subsequent cluster analysis of eight phenotypic descriptors in the whole collection. Summary statistics, especially the low differences of means, equal variance of the traits in both the whole and core collection and the visual inspection of quantile-quantile plots comparing the variation of phenotypic traits present in both collections indicated that the core collection well represented the pattern of diversity of the whole collection. The core collection was genotyped with 20 simple sequence repeat markers and a mini core set of 289 accessions was selected, which depicted the allele and genotype diversity of the core collection. The mungbean core and mini core collections plus their phenotypic and genotypic data are available for distribution to breeders. It is expected that these collections will enhance the access to biodiverse mungbean germplasm for breeding.

  5. JOYO MK-II core characteristics database

    International Nuclear Information System (INIS)

    Ohkawachi, Yasushi; Maeda, Shigetaka; Sekine, Takashi; Aoyama, Takafumi

    2003-04-01

    The 'JOYO' MK-II core characteristics database was compiled and published in 1998. Comments and requests from many users led to the creation of a revised edition. The revisions include changes to the MAGI calculation code system to use the 70 group JFS-3-J3.2 constant set processed from the JENDL-3.2 library. Total control rod worth, reactor kinetic parameters and the MK-II core performance test results were included per user's requests. The core characteristics obtained from the 32 nd to 35 th operational cycles, which were conducted in the MK-III transition core, were newly added in this revised version. The MK-II core management data and core characteristics data were recorded to CD-ROM for user convenience. The Configuration Data' include the core arrangement and refueling record for each operational cycle. The 'Subassembly Library Data' include the atomic number density, neutron fluence, burn-up, integral power of 362 driver fuel subassemblies and 69 irradiation test subassemblies. The 'Output Data' contain the calculated neutron flux, gamma flux, power density, linear heat rate, coolant and fuel temperature distribution of all the fuel subassemblies at the beginning and end of each operational cycle. The 'Core Characteristics Data' include the measured excess reactivity, control rod worth calibration curve, and reactivity coefficients of temperature, power and burn-up. (author)

  6. Sodium Tetraphenylborate Catalyst Identification: Preliminary Studies Set 2

    International Nuclear Information System (INIS)

    Barnes, M.J.

    1997-05-01

    This document details the results of these tests and represents the second report of the task designed to identify soluble NaTPB decomposition catalysts. This task, performed as part of the DNFSB Recommendation 96-1 Implementation Plan, partially fulfills the request by High Level Waste Engineering and the ITP Flow Sheet Team in task Technical Request HLW-TTR-97008

  7. Preliminaries to an investigation of reduced product set finance

    NARCIS (Netherlands)

    Bergstra, J.A.; Middelburg, C.A.

    2010-01-01

    Principles of financial product synthesis from a few basic financial products constitute an interesting research topic inspired by Islamic finance. We make an effort to answer general questions that should be answered before starting to investigate the main issues concerning this topic with the

  8. Preliminaries to an investigation of reduced product set finance

    NARCIS (Netherlands)

    Bergstra, J.A.; Middelburg, C.A.

    2011-01-01

    Principles of financial product synthesis from a few basic financial products constitute an interesting research topic inspired by Islamic finance. We make an effort to answer general questions that should be answered before starting to investigate the main issues concerning this topic with the

  9. Location of a new ice core site at Talos Dome (East Antarctica

    Directory of Open Access Journals (Sweden)

    I. Tabacco

    2006-06-01

    Full Text Available In the frame of glaciology and palaeoclimate research, Talos Dome (72°48lS; 159°06lE, an ice dome on the East Antarctic plateau, represents the new selected site for a new deep ice core drilling. The increasing interest in this region is due to the fact that the ice accumulation is higher here than in other domes in East Antarctica. A new deep drilling in this site could give important information about the climate changes near the coast. Previous papers showed that the dome summit is situated above a sloped bedrock. A new position on a relatively flat bedrock 5-6 km far from here in the SE direction was defined as a possible new ice core site for an European (Italy, France, Swiss and United Kingdom drilling project named as TALDICE (TALos Dome Ice Core Project. This point, named as ID1 (159°11l00mE; 72°49l40mS, became the centre of the Radio Echo Sounding (RES flight plan during the 2003 Italian Antarctic expedition, with the aim of confirming the new drilling site choice. In this paper 2001 and 2003 RES data sets have been used to draw a better resolution of ice thickness, bottom morphology and internal layering of a restricted area around the dome. Based on the final results, point ID1 has been confirmed as the new coring site. Finally, the preliminary operations about the installation of the summer ice core camp (TALDICE at ID1 site carried out during the XX Italian Antarctic expedition (November 2004-December 2005 are briefly described.

  10. Melt spreading code assessment, modifications, and initial application to the EPR core catcher design

    International Nuclear Information System (INIS)

    Farmer, M.T.; Basu, S.

    2009-01-01

    The Evolutionary Power Reactor (EPR) is a 1,600-MWe Pressurized Water Reactor (PWR) that is undergoing a design certification review by the U.S. Nuclear Regulatory Commission (NRC). The EPR severe accident design philosophy is predicated upon the fact that the projected power rating results in a narrow margin for in-vessel melt retention by external flooding. As a result, the design addresses ex-vessel core melt stabilization using a mitigation strategy that includes: 1) an external core melt retention system to temporarily hold core melt released from the vessel; 2) a layer of 'sacrificial' material that is admixed with the melt while in the core melt retention system; 3) a melt plug that, when failed, provides a pathway for the mixture to spread to a large core spreading chamber; and finally, 4) cooling and stabilization of the spread melt by controlled top and bottom flooding. The melt spreading process relies heavily on inertial flow of a low-viscosity admixed melt to a segmented spreading chamber, and assumes that the melt mass will be distributed to a uniform height in the chamber. The spreading phenomenon thus needs to be modeled properly in order to adequately assess the EPR design. The MELTSPREAD code, developed at Argonne National Laboratory, can model segmented, and both uniform and non-uniform spreading. The NRC is using MELTSPREAD to evaluate melt spreading in the EPR design. The development of MELTSPREAD ceased in the early 1990's, and so the code was first assessed against the more contemporary spreading database and code modifications, as warranted, were carried out before performing confirmatory plant calculations. This paper provides principle findings from the MELTSPREAD assessment activities and resulting code modifications, and also summarizes the results of initial scoping calculations for the EPR plant design and preliminary plant analyses, along with the plan for performing the final set of plant calculations including sensitivity studies

  11. PWR core design calculations

    International Nuclear Information System (INIS)

    Trkov, A.; Ravnik, M.; Zeleznik, N.

    1992-01-01

    Functional description of the programme package Cord-2 for PWR core design calculations is presented. Programme package is briefly described. Use of the package and calculational procedures for typical core design problems are treated. Comparison of main results with experimental values is presented as part of the verification process. (author) [sl

  12. Aberrations in preliminary design of ITER divertor impurity influx monitor

    Energy Technology Data Exchange (ETDEWEB)

    Kitazawa, Sin-iti, E-mail: kitazawa.siniti@jaea.go.jp [Naka Fusion Institute, Japan Atomic Energy Agency, JAEA, Naka 311-0193 (Japan); Ogawa, Hiroaki [Naka Fusion Institute, Japan Atomic Energy Agency, JAEA, Naka 311-0193 (Japan); Katsunuma, Atsushi; Kitazawa, Daisuke [Core Technology Center, Nikon Corporation, Yokohama 244-8533 (Japan); Ohmori, Keisuke [Customized Products Business Unit, Nikon Corporation, Mito 310-0843 (Japan)

    2015-12-15

    Highlights: • Divertor impurity influx monitor for ITER (DIM) is procured by JADA. • DIM is designed to observe light from nuclear fusion plasma directly. • DIM is under preliminary design phase. • The spot diagrams were suppressed within the core of receiving fiber. • The aberration of DIM is suppressed in the preliminary design. - Abstract: Divertor impurity influx monitor for ITER (DIM) is a diagnostic system that observes light from nuclear fusion plasma directly. This system is affected by various aberrations because it observes light from the fan-array chord near the divertor in the ultraviolet–near infrared wavelength range. The aberrations should be suppressed to the extent possible to observe the light with very high spatial resolution. In the preliminary design of DIM, spot diagrams were suppressed within the core of the receiving fiber's cross section, and the resulting spatial resolutions satisfied the design requirements.

  13. Aberrations in preliminary design of ITER divertor impurity influx monitor

    International Nuclear Information System (INIS)

    Kitazawa, Sin-iti; Ogawa, Hiroaki; Katsunuma, Atsushi; Kitazawa, Daisuke; Ohmori, Keisuke

    2015-01-01

    Highlights: • Divertor impurity influx monitor for ITER (DIM) is procured by JADA. • DIM is designed to observe light from nuclear fusion plasma directly. • DIM is under preliminary design phase. • The spot diagrams were suppressed within the core of receiving fiber. • The aberration of DIM is suppressed in the preliminary design. - Abstract: Divertor impurity influx monitor for ITER (DIM) is a diagnostic system that observes light from nuclear fusion plasma directly. This system is affected by various aberrations because it observes light from the fan-array chord near the divertor in the ultraviolet–near infrared wavelength range. The aberrations should be suppressed to the extent possible to observe the light with very high spatial resolution. In the preliminary design of DIM, spot diagrams were suppressed within the core of the receiving fiber's cross section, and the resulting spatial resolutions satisfied the design requirements.

  14. Precise seismic-wave velocity atop Earth's core: No evidence for outer-core stratification

    Science.gov (United States)

    Alexandrakis, Catherine; Eaton, David W.

    2010-05-01

    Earth's outer core is composed of liquid Fe and Ni alloyed with a ˜10% fraction of light elements such as O, S, or Si. Secular cooling and compositional buoyancy drive vigorous convection that sustains the geodynamo, but critical details of light-element composition and thermal regime remain uncertain. Seismic velocities can provide important observational constraints on these parameters, but global reference models such as Preliminary Reference Earth Model ( PREM), IASP91 and AK135 exhibit significant discrepancies in the outermost ˜200 km of the core. Here, we apply an Empirical Transfer Function method to obtain precise arrival times for SmKS waves, a whispering-gallery mode that propagates near the underside of the core-mantle boundary. Models that fit our data are all characterized by seismic velocities and depth gradients in the outermost 200 km of the core that correspond best with PREM. This similarity to PREM, which has a smooth velocity profile that satisfies the adiabatic Adams and Williamson equation, argues against the presence of an anomalous layer of light material near the top of the core as suggested in some previous studies. A new model, AE09, is proposed as a slight modification to PREM for use as a reference model of the outermost core.

  15. Replaceable LMFBR core components

    International Nuclear Information System (INIS)

    Evans, E.A.; Cunningham, G.W.

    1976-01-01

    Much progress has been made in understanding material and component performance in the high temperature, fast neutron environment of the LMFBR. Current data have provided strong assurance that the initial core component lifetime objectives of FFTF and CRBR can be met. At the same time, this knowledge translates directly into the need for improved core designs that utilize improved materials and advanced fuels required to meet objectives of low doubling times and extended core component lifetimes. An industrial base for the manufacture of quality core components has been developed in the US, and all procurements for the first two core equivalents for FFTF will be completed this year. However, the problem of fabricating recycled plutonium while dramatically reducing fabrication costs, minimizing personnel exposure, and protecting public health and safety must be addressed

  16. Lunar Core and Tides

    Science.gov (United States)

    Williams, J. G.; Boggs, D. H.; Ratcliff, J. T.

    2004-01-01

    Variations in rotation and orientation of the Moon are sensitive to solid-body tidal dissipation, dissipation due to relative motion at the fluid-core/solid-mantle boundary, and tidal Love number k2 [1,2]. There is weaker sensitivity to flattening of the core-mantle boundary (CMB) [2,3,4] and fluid core moment of inertia [1]. Accurate Lunar Laser Ranging (LLR) measurements of the distance from observatories on the Earth to four retroreflector arrays on the Moon are sensitive to lunar rotation and orientation variations and tidal displacements. Past solutions using the LLR data have given results for dissipation due to solid-body tides and fluid core [1] plus Love number [1-5]. Detection of CMB flattening, which in the past has been marginal but improving [3,4,5], now seems significant. Direct detection of the core moment has not yet been achieved.

  17. Internal core tightener

    International Nuclear Information System (INIS)

    Brynsvold, G.V.; Snyder, H.J. Jr.

    1976-01-01

    An internal core tightener is disclosed which is a linear actuated (vertical actuation motion) expanding device utilizing a minimum of moving parts to perform the lateral tightening function. The key features are: (1) large contact areas to transmit loads during reactor operation; (2) actuation cam surfaces loaded only during clamping and unclamping operation; (3) separation of the parts and internal operation involved in the holding function from those involved in the actuation function; and (4) preloaded pads with compliant travel at each face of the hexagonal assembly at the two clamping planes to accommodate thermal expansion and irradiation induced swelling. The latter feature enables use of a ''fixed'' outer core boundary, and thus eliminates the uncertainty in gross core dimensions, and potential for rapid core reactivity changes as a result of core dimensional change. 5 claims, 12 drawing figures

  18. Numerical studies of rotational core collapse in axisymmetry using the conformally flat metric approach

    International Nuclear Information System (INIS)

    Dimmelmeier, H.; Font, J.A.; Mueller, E.

    2001-01-01

    The numerical simulation of hydrodynamic processes in general relativity is a highly complex problem. In order to reduce the complexity of the gravitational field equations, Wilson and coworkers have proposed an approximation scheme, where the 3-metric γ ij is chosen to be conformally flat. In this approximation the Einstein equations reduce to a set of 5 coupled elliptic equations. In this paper we present an axisymmetric general relativistic hydrodynamic code which utilizes this approach together with high-resolution shock-capturing schemes to solve the hydrodynamic equations. We report on tests and preliminary applications of the code to rotating neutron stars and supernova core collapse in axisymmetry. The code promises good applicability to handle a variety of relativistic astrophysical situations, and is prepared to provide information about gravitational radiation from rotating gravitational collapse. (author)

  19. Core Cognition and Embodied Agency in Gaming

    DEFF Research Database (Denmark)

    Gregersen, Andreas Lindegaard

    The dissertation is premised on the assumption that video game structure is geared towards the functionality of challenging interaction by embodied human individuals. The first chapter introduces "core cognition", referring to a stable and common human embodiment of cognitive powers related...... to perception and cognition. The next chapter analyses intentional goal-related action and embodied awareness of action in depth. This is followed by a discussion of play and related phenomena leading to the preliminary conclusion that play and playfulness may involve goal-related actions in several ways...... that of the game world, or virtual world. Games are, in accordance with previous claims, defined as simulations of game worlds which are recruited for game functionalities of challenges of control in relation to artificial conflict. On the basis of core cognition, intentional agency, and play-related phenomena...

  20. Safety performance of preliminary KALIMER conceptual design

    Energy Technology Data Exchange (ETDEWEB)

    Hahn Dohee; Kim Kyoungdoo; Kwon Youngmin; Chang Wonpyo; Suk Soodong [Korea atomic Energy Resarch Inst., Taejon (Korea)

    1999-07-01

    The Korea Atomic Energy Research Institute (KAERI) is developing KALIMER (Korea Advanced Liquid Metal Reactor), which is a sodium cooled, 150 MWe pool-type reactor. The safety design of KALIMER emphasizes accident prevention by using passive processes, which can be accomplished by the safety design objectives including the utilization of inherent safety features. In order to assess the effectiveness of the inherent safety features in achieving the safety design objectives, a preliminary evaluation of ATWS performance for the KALIMER design has been performed with SSC-K code, which is a modified version of SSC-L code. KAERI's modification of the code includes development of reactivity feedback models for the core and a pool model for KALIMER reactor vessel. This paper describes the models for control rod driveline expansion, gas expansion module and the thermal hydraulic model for reactor pool and the results of preliminary analyses for unprotected loss of flow and loss o heat sink. (author)

  1. Safety performance of preliminary KALIMER conceptual design

    International Nuclear Information System (INIS)

    Hahn Dohee; Kim Kyoungdoo; Kwon Youngmin; Chang Wonpyo; Suk Soodong

    1999-01-01

    The Korea Atomic Energy Research Institute (KAERI) is developing KALIMER (Korea Advanced Liquid Metal Reactor), which is a sodium cooled, 150 MWe pool-type reactor. The safety design of KALIMER emphasizes accident prevention by using passive processes, which can be accomplished by the safety design objectives including the utilization of inherent safety features. In order to assess the effectiveness of the inherent safety features in achieving the safety design objectives, a preliminary evaluation of ATWS performance for the KALIMER design has been performed with SSC-K code, which is a modified version of SSC-L code. KAERI's modification of the code includes development of reactivity feedback models for the core and a pool model for KALIMER reactor vessel. This paper describes the models for control rod driveline expansion, gas expansion module and the thermal hydraulic model for reactor pool and the results of preliminary analyses for unprotected loss of flow and loss o heat sink. (author)

  2. Grain alignment in starless cores

    Energy Technology Data Exchange (ETDEWEB)

    Jones, T. J.; Bagley, M. [Minnesota Institute for Astrophysics, University of Minnesota, Minneapolis, MN 55455 (United States); Krejny, M. [Cree Inc., 4600 Silicon Dr., Durham, NC (United States); Andersson, B.-G. [SOFIA Science Center, USRA, Moffett Field, CA (United States); Bastien, P., E-mail: tjj@astro.umn.edu [Centre de recherche en astrophysique du Québec and Départment de Physique, Université de Montréal, Montréal (Canada)

    2015-01-01

    We present near-IR polarimetry data of background stars shining through a selection of starless cores taken in the K band, probing visual extinctions up to A{sub V}∼48. We find that P{sub K}/τ{sub K} continues to decline with increasing A{sub V} with a power law slope of roughly −0.5. Examination of published submillimeter (submm) polarimetry of starless cores suggests that by A{sub V}≳20 the slope for P versus τ becomes ∼−1, indicating no grain alignment at greater optical depths. Combining these two data sets, we find good evidence that, in the absence of a central illuminating source, the dust grains in dense molecular cloud cores with no internal radiation source cease to become aligned with the local magnetic field at optical depths greater than A{sub V}∼20. A simple model relating the alignment efficiency to the optical depth into the cloud reproduces the observations well.

  3. Earth's inner core: Innermost inner core or hemispherical variations?

    NARCIS (Netherlands)

    Lythgoe, K. H.; Deuss, A.|info:eu-repo/dai/nl/412396610; Rudge, J. F.; Neufeld, J. A.

    2014-01-01

    The structure of Earth's deep inner core has important implications for core evolution, since it is thought to be related to the early stages of core formation. Previous studies have suggested that there exists an innermost inner core with distinct anisotropy relative to the rest of the inner core.

  4. Dependence of Core and Extended Flux on Core Dominance ...

    Indian Academy of Sciences (India)

    Abstract. Based on two extragalactic radio source samples, the core dominance parameter is calculated, and the correlations between the core/extended flux density and core dominance parameter are investi- gated. When the core dominance parameter is lower than unity, it is linearly correlated with the core flux density, ...

  5. Korrelasjon mellom core styrke, core stabilitet og utholdende styrke i core

    OpenAIRE

    Berg-Olsen, Andrea Marie; Fugelsøy, Eivor; Maurstad, Ann-Louise

    2010-01-01

    Formålet med studien var å se hvilke korrelasjon det er mellom core styrke, core stabilitet og utholdende styrke i core. Testingen bestod av tre hoveddeler hvor vi testet core styrke, core stabilitet og utholdende styrke i core. Innenfor core styrke og utholdende styrke i core ble tre ulike tester utført. Ved måling av core stabilitet ble det gjennomført kun en test. I core styrke ble isometrisk abdominal fleksjon, isometrisk rygg ekstensjon og isometrisk lateral fleksjon testet. Sit-ups p...

  6. Windscale pile core surveys

    International Nuclear Information System (INIS)

    Curtis, R.F.; Mathews, R.F.

    1996-01-01

    The two Windscale Piles were closed down, defueled as far as possible and mothballed for thirty years following a fire in the core of Pile 1 in 1957 resulting from the spontaneous release of stored Wigner energy in the graphite moderator. Decommissioning of the reactors commenced in 1987 and has reached the stage where the condition of both cores needs to be determined. To this end, non-intrusive and intrusive surveys and sampling of the cores have been planned and partly implemented. The objectives for each Pile differ slightly. The location and quantity of fuel remaining in the damaged core of Pile 1 needed to be established, whereas the removal of all fuel from Pile 2 needed to be confirmed. In Pile 1, the possible existence of a void in the core is to be explored and in Pile 2, the level of Wigner energy remaining required to be quantified. Levels of radioactivity in both cores needed to be measured. The planning of the surveys is described including strategy, design, safety case preparation and the remote handling and viewing equipment required to carry out the inspection, sampling and monitoring work. The results from the completed non-intrusive survey of Pile 2 are summarised. They confirm that the core is empty and the graphite is in good condition. The survey of Pile 1 has just started. (UK)

  7. Safety evaluation of accident-tolerant FCM fueled core with SiC-coated zircalloy cladding for design-basis-accidents and beyond DBAs

    Energy Technology Data Exchange (ETDEWEB)

    Chun, Ji-Han, E-mail: chunjh@kaeri.re.kr; Lim, Sung-Won; Chung, Bub-Dong; Lee, Won-Jae

    2015-08-15

    Highlights: • Thermal conductivity model of the FCM fuel was developed and adopted in the MARS. • Scoping analysis for candidate FCM FAs was performed to select feasible FA. • Preliminary safety criteria for FCM fuel and SiC/Zr cladding were set up. • Enhanced safety margin and accident tolerance for FCM-SiC/Zr core were demonstrated. - Abstract: The FCM fueled cores proposed as an accident tolerant concept is assessed against the design-basis-accident (DBA) and the beyond-DBA (BDBA) scenarios using MARS code. A thermal conductivity model of FCM fuel is incorporated in the MARS code to take into account the effects of irradiation and temperature that was recently measured by ORNL. Preliminary analyses regarding the initial stored energy and accident tolerant performance were carried out for the scoping of various cladding material candidates. A 16 × 16 FA with SiC-coated Zircalloy cladding was selected as the feasible conceptual design through a preliminary scoping analysis. For a selected design, safety analyses for DBA and BDBA scenarios were performed to demonstrate the accident tolerance of the FCM fueled core. A loss of flow accident (LOFA) scenario was selected for a departure-from-nucleate-boiling (DNB) evaluation, and large-break loss of coolant accident (LBLOCA) scenario for peak cladding temperature (PCT) margin evaluation. A control element assembly (CEA) ejection accident scenario was selected for peak fuel enthalpy and temperature. Moreover, a station blackout (SBO) and LBLOCA without a safety injection (SI) scenario were selected as a BDBA. It was demonstrated that the DBA safety margin of the FCM core is satisfied and the time for operator actions for BDBA s is evaluated.

  8. Effective core potential methods for the lanthanides

    International Nuclear Information System (INIS)

    Cundari, T.R.; Stevens, W.J.

    1993-01-01

    In this paper a complete set of effective core potentials (ECPs) and valence basis sets for the lanthanides (Ce to Lu) are derived. These ECPs are consistent not only within the lanthanide series, but also with the third-row transition metals which bracket them. A 46-electron core was chosen to provide the best compromise between computational savings and chemical accuracy. Thus, the 5s and 5p are included as ''outer'' core while all lower energy atomic orbitals (AOs) are replaced with the ECP. Generator states were chosen from the most chemically relevant +3 and +2 oxidation states. The results of atomic calculations indicate that the greatest error vs highly accurate numerical potential/large, even-tempered basis set calculations results from replacement of the large, even-tempered basis sets with more compact representations. However, the agreement among atomic calculations remains excellent with both basis set sizes, for a variety of spin and oxidation states, with a significant savings in time for the optimized valence basis set. It is expected that the compact representation of the ECPs and valence basis sets will eventually encourage their use by computational chemists to further explore the bonding and reactivity of lanthanide complexes

  9. Cordilleran metamorphic core complexes and their uranium favorability

    International Nuclear Information System (INIS)

    Coney, P.J.; Reynolds, S.J.

    1980-11-01

    The objective of this report is to provide a descriptive body of knowledge on Cordilleran metamorphic core complexes including their lithologic and structural characteristics, their distribution within the Cordillera, and their evolutionary history and tectonic setting. The occurrence of uranium in the context of possibility for uranium concentration is also examined. This volume contains appendices of the following: annotated bibliography of Cordilleran metamorphic core complexes; annotated bibliography of the uranium favorability of Cordilleran metamorphic core complexes; uranium occurrences in the Cordilleran metamorphic core complex belt; and geology, uranium favorability, uranium occurrences and tectonic maps of individual Cordilleran metamorphic core complexes; and locations, lithologic descriptions, petrographic information and analytical data for geochemical samples

  10. Status of reactor core design code system in COSINE code package

    International Nuclear Information System (INIS)

    Chen, Y.; Yu, H.; Liu, Z.

    2014-01-01

    For self-reliance, COre and System INtegrated Engine for design and analysis (COSINE) code package is under development in China. In this paper, recent development status of the reactor core design code system (including the lattice physics code and the core simulator) is presented. The well-established theoretical models have been implemented. The preliminary verification results are illustrated. And some special efforts, such as updated theory models and direct data access application, are also made to achieve better software product. (author)

  11. Status of reactor core design code system in COSINE code package

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Y.; Yu, H.; Liu, Z., E-mail: yuhui@snptc.com.cn [State Nuclear Power Software Development Center, SNPTC, National Energy Key Laboratory of Nuclear Power Software (NEKLS), Beijiing (China)

    2014-07-01

    For self-reliance, COre and System INtegrated Engine for design and analysis (COSINE) code package is under development in China. In this paper, recent development status of the reactor core design code system (including the lattice physics code and the core simulator) is presented. The well-established theoretical models have been implemented. The preliminary verification results are illustrated. And some special efforts, such as updated theory models and direct data access application, are also made to achieve better software product. (author)

  12. Core shroud corner joints

    Science.gov (United States)

    Gilmore, Charles B.; Forsyth, David R.

    2013-09-10

    A core shroud is provided, which includes a number of planar members, a number of unitary corners, and a number of subassemblies each comprising a combination of the planar members and the unitary corners. Each unitary corner comprises a unitary extrusion including a first planar portion and a second planar portion disposed perpendicularly with respect to the first planar portion. At least one of the subassemblies comprises a plurality of the unitary corners disposed side-by-side in an alternating opposing relationship. A plurality of the subassemblies can be combined to form a quarter perimeter segment of the core shroud. Four quarter perimeter segments join together to form the core shroud.

  13. IGCSE core mathematics

    CERN Document Server

    Wall, Terry

    2013-01-01

    Give your core level students the support and framework they require to get their best grades with this book dedicated to the core level content of the revised syllabus and written specifically to ensure a more appropriate pace. This title has been written for Core content of the revised Cambridge IGCSE Mathematics (0580) syllabus for first teaching from 2013. ? Gives students the practice they require to deepen their understanding through plenty of practice questions. ? Consolidates learning with unique digital resources on the CD, included free with every book. We are working with Cambridge

  14. Validation of reactor core protection system

    International Nuclear Information System (INIS)

    Lee, Sang-Hoon; Bae, Jong-Sik; Baeg, Seung-Yeob; Cho, Chang-Ho; Kim, Chang-Ho; Kim, Sung-Ho; Kim, Hang-Bae; In, Wang-Kee; Park, Young-Ho

    2008-01-01

    Reactor COre Protection System (RCOPS), an advanced core protection calculator system, is a digitized one which provides core protection function based on two reactor core operation parameters, Departure from Nucleate Boiling Ratio (DNBR) and Local Power Density (LPD). It generates a reactor trip signal when the core condition exceeds the DNBR or LPD design limit. It consists of four independent channels adapted a two-out-of-four trip logic. System configuration, hardware platform and an improved algorithm of the newly designed core protection calculator system are described in this paper. One channel of RCOPS was implemented as a single channel facility for this R and D project where we performed final integration software testing. To implement custom function blocks, pSET is used. Software test is performed by two methods. The first method is a 'Software Module Test' and the second method is a 'Software Unit Test'. New features include improvement of core thermal margin through a revised on-line DNBR algorithm, resolution of the latching problem of control element assembly signal and addition of the pre-trip alarm generation. The change of the on-line DNBR calculation algorithm is considered to improve the DNBR net margin by 2.5%-3.3%. (author)

  15. Feasibility Study of Core Design with a Monte Carlo Code for APR1400 Initial core

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jinsun; Chang, Do Ik; Seong, Kibong [KEPCO NF, Daejeon (Korea, Republic of)

    2014-10-15

    The Monte Carlo calculation becomes more popular and useful nowadays due to the rapid progress in computing power and parallel calculation techniques. There have been many attempts to analyze a commercial core by Monte Carlo transport code using the enhanced computer capability, recently. In this paper, Monte Carlo calculation of APR1400 initial core has been performed and the results are compared with the calculation results of conventional deterministic code to find out the feasibility of core design using Monte Carlo code. SERPENT, a 3D continuous-energy Monte Carlo reactor physics burnup calculation code is used for this purpose and the KARMA-ASTRA code system, which is used for a deterministic code of comparison. The preliminary investigation for the feasibility of commercial core design with Monte Carlo code was performed in this study. Simplified core geometry modeling was performed for the reactor core surroundings and reactor coolant model is based on two region model. The reactivity difference at HZP ARO condition between Monte Carlo code and the deterministic code is consistent with each other and the reactivity difference during the depletion could be reduced by adopting the realistic moderator temperature. The reactivity difference calculated at HFP, BOC, ARO equilibrium condition was 180 ±9 pcm, with axial moderator temperature of a deterministic code. The computing time will be a significant burden at this time for the application of Monte Carlo code to the commercial core design even with the application of parallel computing because numerous core simulations are required for actual loading pattern search. One of the remedy will be a combination of Monte Carlo code and the deterministic code to generate the physics data. The comparison of physics parameters with sophisticated moderator temperature modeling and depletion will be performed for a further study.

  16. GFR fuel and core pre-conceptual design studies

    International Nuclear Information System (INIS)

    Chauvin, N.; Ravenet, A.; Lorenzo, D.; Pelletier, M.; Escleine, J.M.; Munoz, I.; Bonnerot, J.M.; Malo, J.Y.; Garnier, J.C.; Bertrand, F.; Bosq, J.C.

    2007-01-01

    The revision of the GFR core design - plate type - has been undertaken since previous core presented at Global'05. The self-breeding searched for has been achieved with an optimized design ('12/06 E'). The higher core pressure drop was a matter of concern. First of all, the core coolability in natural circulation for pressurized conditions has been studied and preliminary plant transient calculations have been performed. The design and safety criteria are met but no more margin remains. The project is also addressing the feasibility and the design of the fuel S/A. The hexagonal shape together with the principle of closed S/A (wrapper tube) is kept. Ceramic plate type fuel element combines a high enough core power density (minimization of the Pu inventory) and plutonium and minor actinides recycling capabilities. Innovative for many aspects, the fuel element is central to the GFR feasibility. It is supported already by a significant R and D effort also applicable to a pin concept that is considered as the other fuel element of interest. This combination of fuel/core feasibility and performance analysis, safety dispositions and performances analysis will compose the 'GFR preliminary feasibility' which is a project milestone at the end of the year 2007. (authors)

  17. Heterogeneous gas core reactor

    International Nuclear Information System (INIS)

    Diaz, N.J.; Dugan, E.T.

    1983-01-01

    A heterogeneous gas core nuclear reactor is disclosed comprising a core barrel provided interiorly with an array of moderator-containing tubes and being otherwise filled with a fissile and/or fertile gaseous fuel medium. The fuel medium may be flowed through the chamber and through an external circuit in which heat is extracted. The moderator may be a fluid which is flowed through the tubes and through an external circuit in which heat is extracted. The moderator may be a solid which may be cooled by a fluid flowing within the tubes and through an external heat extraction circuit. The core barrel is surrounded by moderator/coolant material. Fissionable blanket material may be disposed inwardly or outwardly of the core barrel

  18. iPSC Core

    Data.gov (United States)

    Federal Laboratory Consortium — The induced Pluripotent Stem Cells (iPSC) Core was created in 2011 to accelerate stem cell research in the NHLBI by providing investigators consultation, technical...

  19. Core Flight Software

    Data.gov (United States)

    National Aeronautics and Space Administration — The AES Core Flight Software (CFS) project purpose is to analyze applicability, and evolve and extend the reusability of the CFS system originally developed by...

  20. PWR degraded core analysis

    International Nuclear Information System (INIS)

    Gittus, J.H.

    1982-04-01

    A review is presented of the various phenomena involved in degraded core accidents and the ensuing transport of fission products from the fuel to the primary circuit and the containment. The dominant accident sequences found in the PWR risk studies published to date are briefly described. Then chapters deal with the following topics: the condition and behaviour of water reactor fuel during normal operation and at the commencement of degraded core accidents; the generation of hydrogen from the Zircaloy-steam and the steel-steam reactions; the way in which the core deforms and finally melts following loss of coolant; debris relocation analysis; containment integrity; fission product behaviour during a degraded core accident. (U.K.)

  1. Restraint system for core elements of a reactor core

    International Nuclear Information System (INIS)

    Class, G.

    1975-01-01

    In a nuclear reactor, a core element bundle formed of a plurality of side-by-side arranged core elements is surrounded by restraining elements that exert a radially inwardly directly restraining force generating friction forces between the core elements in a restraining plane that is transverse to the core element axes. The adjoining core elements are in rolling contact with one another in the restraining plane by virtue of rolling-type bearing elements supported in the core elements. (Official Gazette)

  2. FBR type reactor core

    International Nuclear Information System (INIS)

    Tamiya, Tadashi; Kawashima, Katsuyuki; Fujimura, Koji; Murakami, Tomoko.

    1995-01-01

    Neutron reflectors are disposed at the periphery of a reactor core fuel region and a blanket region, and a neutron shielding region is disposed at the periphery of them. The neutron reflector has a hollow duct structure having a sealed upper portion, a lower portion opened to cooling water, in which a gas and coolants separately sealed in the inside thereof. A driving pressure of a primary recycling pump is lowered upon reduction of coolant flow rate, then the liquid level of coolants in the neutron reflector is lowered due to imbalance between the driving pressure and a gas pressure, so that coolants having an effect as a reflector are eliminated from the outer circumference of the reactor core. Therefore, the amount of neutrons leaking from the reactor core is increased, and negative reactivity is charged to the reactor core. The negative reactivity of the neutron reflector is made greater than a power compensation reactivity. Since this enables reactor scram by using an inherent performance of the reactor core, the reactor core safety of an LMFBR-type reactor can be improved. (I.N.)

  3. The earths innermost core

    International Nuclear Information System (INIS)

    Nanda, J.N.

    1989-01-01

    A new earth model is advanced with a solid innermost core at the centre of the Earth where elements heavier than iron, over and above what can be retained in solution in the iron core, are collected. The innermost core is separated from the solid iron-nickel core by a shell of liquid copper. The innermost core has a natural vibration measured on the earth's surface as the long period 26 seconds microseisms. The earth was formed initially as a liquid sphere with a relatively thin solid crust above the Byerly discontinuity. The trace elements that entered the innermost core amounted to only 0.925 ppm of the molten mass. Gravitational differentiation must have led to the separation of an explosive thickness of pure 235 U causing a fission explosion that could expel beyond the Roche limit a crustal scab which would form the centre piece of the moon. A reservoir of helium floats on the liquid copper. A small proportion of helium-3, a relic of the ancient fission explosion present there will spell the exciting magnetic field. The field is stable for thousands of years because of the presence of large quantity of helium-4 which accounts for most of the gaseous collisions that will not disturb the atomic spin of helium-3 atoms. This field is prone to sudden reversals after long periods of stability. (author). 14 refs

  4. Capturing haplotypes in germplasm core collections

    Science.gov (United States)

    Genomewide data sets of single nucleotide polymorphisms (SNPs) offer great potential to improve ex situ conservation. Two factors impede their use for producing core collections. First, due to the large number of SNPs, the assembly of collections that maximize diversity may be intractable using ex...

  5. Core Competencies for Training Effective School Consultants

    Science.gov (United States)

    Burkhouse, Katie Lynn Sutton

    2012-01-01

    The purpose of this research was to develop and validate a set of core competencies of effective school-based consultants for preservice school psychology consultation training. With recent changes in service delivery models, psychologists are challenged to engage in more indirect, preventative practices (Reschly, 2008). Consultation emerges as…

  6. Synthesis of Axial Power Distribution Using 5-Level Ex-core Detector in a Core Protection System

    International Nuclear Information System (INIS)

    Koo, Bon-Seung; Lee, Chung-Chan; Zee, Sung-Quun

    2007-01-01

    In ABB-CE digital plants, Core Protection Calculator System (CPCS) is used for a core protection based on several online measured system parameters including 3- level safety grade ex-core detector signals. The CPCS provides four independent channels for the departure from a nucleate boiling ratio (DNBR) and local power density (LPD) trip signals to the reactor protection system. Each channel consists of a core protection calculator (CPC) and a control element assembly calculator (CEAC). The cubic spline synthesis technique has been used in online calculations of the core axial power distributions using 3-level ex-core detector signals in CPC. The pre-determined cubic spline function sets are used depending on the characteristics of the ex-core detector responses. But this method shows large power distribution errors for the extremely skewed axial shapes due to restrictive function sets and an incorrect SAM value. Especially thus situation is worse at a higher burnup. To solve these problems, the cubic spline function sets are improved and it is demonstrated that the axial power shapes can be synthesized more accurately with the new function sets than those of a conventional CPC. In this paper, synthesis of an axial power distribution using a 5-level ex-core detector is described and the axial power distributions are compared between 3-level and 5-level ex-core detector systems

  7. Note Taking in Multi-Media Settings

    Science.gov (United States)

    Black, Kelly; Yao, Guangming

    2014-01-01

    We provide a preliminary exploration into the use of note taking when combined with video examples. Student volunteers were divided into three groups and asked to perform two problems. The first problem was explored in a classroom setting and the other problem was a novel problem. The students were asked to complete the two questions. Furthermore,…

  8. First combined total reflection X-ray fluorescence and grazing incidence X-ray absorption spectroscopy characterization of aeolian dust archived in Antarctica and Alpine deep ice cores

    Energy Technology Data Exchange (ETDEWEB)

    Cibin, G. [Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxon OX110DE (United Kingdom); IMONT/EIM, Ente Italiano della Montagna, P.za dei Caprettari 70, 00176 Roma (Italy); Universita' degli Studi di Roma Tre, Dipartimento di Scienze Geologiche, L.go S. Leonardo Murialdo 1, 00146 Roma (Italy)], E-mail: giannantonio.cibin@diamond.ac.uk; Marcelli, A. [INFN - Laboratori Nazionali di Frascati, P.O. Box 13, 00044 Frascati (Roma) (Italy); Maggi, V. [Universita degli Studi di Milano-Bicocca, Dipartimento di Scienze dell' Ambiente e del Territorio, Piazza della Scienza 1, 20126 Milano (Italy); Sala, M. [Universita degli Studi di Milano-Bicocca, Dipartimento di Scienze dell' Ambiente e del Territorio, Piazza della Scienza 1, 20126 Milano (Italy); Universita degli Studi di Milano, Dipartimento di Scienze della Terra ' A. Desio' , Sez. Mineralogia, Via Mangiagalli 34, 20133 Milano (Italy); Marino, F.; Delmonte, B. [Universita degli Studi di Milano-Bicocca, Dipartimento di Scienze dell' Ambiente e del Territorio, Piazza della Scienza 1, 20126 Milano (Italy); Albani, S. [Universita degli Studi di Milano-Bicocca, Dipartimento di Scienze dell' Ambiente e del Territorio, Piazza della Scienza 1, 20126 Milano (Italy); Universita degli Studi di Siena, Dottorato in Scienze Polari, via Laterina 8, 53100 Siena (Italy); Pignotti, S. [IMONT/EIM, Ente Italiano della Montagna, P.za dei Caprettari 70, 00176 Roma (Italy)

    2008-12-15

    Aeolian mineral dust archived in polar and mid latitude ice cores represents a precious proxy for assessing environmental and climatic variations at different timescales. In this respect, the identification of dust mineralogy plays a key role. In this work we performed the first preliminary X-ray absorption spectroscopy (XAS) experiments on mineral dust particles extracted from Antarctic and from Alpine firn cores using grazing incidence geometry at the Fe K-edge. A dedicated high vacuum experimental chamber was set up for normal-incidence and total-reflection X-Ray Fluorescence and Absorption Spectroscopy analyses on minor amounts of mineral materials at the Stanford Synchrotron Radiation Laboratory. Results show that this experimental technique and protocol allows recognizing iron inclusion mineral fraction on insoluble dust in the 1-10 {mu}g range.

  9. First combined total reflection X-ray fluorescence and grazing incidence X-ray absorption spectroscopy characterization of aeolian dust archived in Antarctica and Alpine deep ice cores

    International Nuclear Information System (INIS)

    Cibin, G.; Marcelli, A.; Maggi, V.; Sala, M.; Marino, F.; Delmonte, B.; Albani, S.; Pignotti, S.

    2008-01-01

    Aeolian mineral dust archived in polar and mid latitude ice cores represents a precious proxy for assessing environmental and climatic variations at different timescales. In this respect, the identification of dust mineralogy plays a key role. In this work we performed the first preliminary X-ray absorption spectroscopy (XAS) experiments on mineral dust particles extracted from Antarctic and from Alpine firn cores using grazing incidence geometry at the Fe K-edge. A dedicated high vacuum experimental chamber was set up for normal-incidence and total-reflection X-Ray Fluorescence and Absorption Spectroscopy analyses on minor amounts of mineral materials at the Stanford Synchrotron Radiation Laboratory. Results show that this experimental technique and protocol allows recognizing iron inclusion mineral fraction on insoluble dust in the 1-10 μg range

  10. Some further remarks on good sets

    Indian Academy of Sciences (India)

    Introduction and preliminaries. The purpose of this note is to answer two questions about good sets raised in [4] and [5]. Let X1,X2,...,Xn be nonempty sets and let. = X1 ×X2 ×···×Xn be their cartesian product. We will write x to denote a point (x1,x2,...,xn) ∈ . For each 1 ≤ i ≤ n, i denotes the canonical projection of onto Xi.

  11. Vessel core seismic interaction for a fast reactor

    International Nuclear Information System (INIS)

    Martelli, A.; Maresca, G.

    1984-01-01

    This report deals with the analysis carried out in collaboration between ENEA and NIRA for optimizing the iterative procedure applied for the evaluation of the effects of the vessel core dynamic interaction for a fast reactor in the case of a earthquake. In fact, as shown in a previous report the convergence of such procedure was very slow for the design solution adopted for the PEC reactor, i.e. with a core restraint plate located close to the top of the core elements. This study, although performed making use of preliminary data (the same of the cited previous report) demonstrates that the convergence is fast if a suitable linear core model is applied in the first iteration linear calculations carried out by NIRA, with an intermediate stiffness with respect to those corresponding to the two limit models previously assumed and increased damping coefficients. Thus, the optimized iterative procedures is now applied in the PEC reactor block seismic verification analysis

  12. The AGB bump: a calibrator for core mixing

    Directory of Open Access Journals (Sweden)

    Bossini Diego

    2015-01-01

    Full Text Available The efficiency of convection in stars affects many aspects of their evolution and remains one of the key-open questions in stellar modelling. In particular, the size of the mixed core in core-He-burning low-mass stars is still uncertain and impacts the lifetime of this evolutionary phase and, e.g., the C/O profile in white dwarfs. One of the known observables related to the Horizontal Branch (HB and Asymptotic Giant Branch (AGB evolution is the AGB bump. Its luminosity depends on the position in mass of the helium-burning shell at its first ignition, that is affected by the extension of the central mixed region. In this preliminary work we show how various assumptions on near-core mixing and on the thermal stratification in the overshooting region affect the luminosity of the AGB bump, as well as the period spacing of gravity modes in core-He-burning models.

  13. The FRIGG project: From intermediate galactic scales to self-gravitating cores

    Science.gov (United States)

    Hennebelle, Patrick

    2018-03-01

    Context. Understanding the detailed structure of the interstellar gas is essential for our knowledge of the star formation process. Aim. The small-scale structure of the interstellar medium (ISM) is a direct consequence of the galactic scales and making the link between the two is essential. Methods: We perform adaptive mesh simulations that aim to bridge the gap between the intermediate galactic scales and the self-gravitating prestellar cores. For this purpose we use stratified supernova regulated ISM magneto-hydrodynamical simulations at the kpc scale to set up the initial conditions. We then zoom, performing a series of concentric uniform refinement and then refining on the Jeans length for the last levels. This allows us to reach a spatial resolution of a few 10-3 pc. The cores are identified using a clump finder and various criteria based on virial analysis. Their most relevant properties are computed and, due to the large number of objects formed in the simulations, reliable statistics are obtained. Results: The cores' properties show encouraging agreements with observations. The mass spectrum presents a clear powerlaw at high masses with an exponent close to ≃-1.3 and a peak at about 1-2 M⊙. The velocity dispersion and the angular momentum distributions are respectively a few times the local sound speed and a few 10-2 pc km s-1. We also find that the distribution of thermally supercritical cores present a range of magnetic mass-to-flux over critical mass-to-flux ratios, typically between ≃0.3 and 3 indicating that they are significantly magnetized. Investigating the time and spatial dependence of these statistical properties, we conclude that they are not significantly affected by the zooming procedure and that they do not present very large fluctuations. The most severe issue appears to be the dependence on the numerical resolution of the core mass function (CMF). While the core definition process may possibly introduce some biases, the peak tends to

  14. Reactor core control device

    International Nuclear Information System (INIS)

    Sano, Hiroki

    1998-01-01

    The present invention provides a reactor core control device, in which switching from a manual operation to an automatic operation, and the control for the parameter of an automatic operation device are facilitated. Namely, the hysteresis of the control for the operation parameter by an manual operation input means is stored. The hysteresis of the control for the operation parameter is collected. The state of the reactor core simulated by an operation control to which the collected operation parameters are manually inputted is determined as an input of the reactor core state to the automatic input means. The record of operation upon manual operation is stored as a hysteresis of control for the operation parameter, but the hysteresis information is not only the result of manual operation of the operation parameter. This is results of operation conducted by a skilled operator who judge the state of the reactor core to be optimum. Accordingly, it involves information relevant to the reactor core state. Then, it is considered that the optimum automatic operation is not deviated greatly from the manual operation. (I.S.)

  15. Preliminary nuclear decommissioning cost study

    International Nuclear Information System (INIS)

    Sissingh, R.A.P.

    1981-04-01

    The decommissioning of a nuclear power plant may involve one or more of three possible options: storage with surveillance (SWS), restricted site release (RSR), and unrestricted site use(USU). This preliminary study concentrates on the logistical, technical and cost aspects of decommissioning a multi-unit CANDU generating station using Pickering GS as the reference design. The procedure chosen for evaluation is: i) removal of the fuel and heavy water followed by decontamination prior to placing the station in SWS for thiry years; ii) complete dismantlement to achieve a USU state. The combination of SWS and USU with an interim period of surveillance allows for radioactive decay and hence less occupational exposure in achieving USU. The study excludes the conventional side of the station, assumes waste disposal repositories are available 1600 km away from the station, and uses only presently available technologies. The dismantlement of all systems except the reactor core can be accomplished using Ontario Hydro's current operating, maintenance and construction procedures. The total decommissioning period is spread out over approximately 40 years, with major activities concentrated in the first and last five years. The estimated dose would be approximately 1800 rem. Overall Pickering GS A costs would be $162,000,000 (1980 Canadian dollars)

  16. Three dimensions transport calculations for PWR core

    International Nuclear Information System (INIS)

    Richebois, E.

    2000-01-01

    The objective of this work is to define improved 3-D core calculation methods based on the transport theory. These methods can be particularly useful and lead to more precise computations in areas of the core where anisotropy and steep flux gradients occur, especially near interface and boundary conditions and in regions of high heterogeneity (bundle with absorbent rods). In order to apply the transport theory a new method for calculating reflector constants has been developed, since traditional methods were only suited for 2-group diffusion core calculations and could not be extrapolated to transport calculations. In this thesis work, the new method for obtaining reflector constants is derived regardless of the number of energy groups and of the operator used. The core calculations results using the reflector constants thereof obtained have been validated on the EDF's power reactor Saint Laurent B1 with MOX loading. The advantages of a 3-D core transport calculation scheme have been highlighted as opposed to diffusion methods; there are a considerable number of significant effects and potential advantages to be gained in rod worth calculations for instance. These preliminary results obtained with on particular cycle will have to be confirmed by more systematic analysis. Accidents like MSLB (main steam line break) and LOCA (loss of coolant accident) should also be investigated and constitute challenging situations where anisotropy is high and/or flux gradients are steep. This method is now being validated for others EDF's PWRs' reactors, as well as for experimental reactors and other types of commercial reactors. (author)

  17. The PWR cores management

    International Nuclear Information System (INIS)

    Barral, J.C.; Rippert, D.; Johner, J.

    2000-01-01

    During the meeting of the 25 january 2000, organized by the SFEN, scientists and plant operators in the domain of the PWR debated on the PWR cores management. The five first papers propose general and economic information on the PWR and also the fast neutron reactors chains in the electric power market: statistics on the electric power industry, nuclear plant unit management, the ITER project and the future of the thermonuclear fusion, the treasurer's and chairman's reports. A second part offers more technical papers concerning the PWR cores management: performance and optimization, in service load planning, the cores management in the other countries, impacts on the research and development programs. (A.L.B.)

  18. Molten core retention assembly

    International Nuclear Information System (INIS)

    Lampe, R.F.

    1976-01-01

    Molten fuel produced in a core overheating accident is caught by a molten core retention assembly consisting of a horizontal baffle plate having a plurality of openings therein, heat exchange tubes having flow holes near the top thereof mounted in the openings, and a cylindrical imperforate baffle attached to the plate and surrounding the tubes. The baffle assembly is supported from the core support plate of the reactor by a plurality of hanger rods which are welded to radial beams passing under the baffle plate and intermittently welded thereto. Preferably the upper end of the cylindrical baffle terminates in an outwardly facing lip to which are welded a plurality of bearings having slots therein adapted to accept the hanger rods

  19. Core status computing system

    International Nuclear Information System (INIS)

    Yoshida, Hiroyuki.

    1982-01-01

    Purpose: To calculate power distribution, flow rate and the like in the reactor core with high accuracy in a BWR type reactor. Constitution: Total flow rate signals, traverse incore probe (TIP) signals as the neutron detector signals, thermal power signals and pressure signals are inputted into a process computer, where the power distribution and the flow rate distribution in the reactor core are calculated. A function generator connected to the process computer calculates the absolute flow rate passing through optional fuel assemblies using, as variables, flow rate signals from the introduction part for fuel assembly flow rate signals, data signals from the introduction part for the geometrical configuration data at the flow rate measuring site of fuel assemblies, total flow rate signals for the reactor core and the signals from the process computer. Numerical values thus obtained are given to the process computer as correction signals to perform correction for the experimental data. (Moriyama, K.)

  20. Business System Planning Project, Preliminary System Design

    International Nuclear Information System (INIS)

    EVOSEVICH, S.

    2000-01-01

    CH2M HILL Hanford Group, Inc. (CHG) is currently performing many core business functions including, but not limited to, work control, planning, scheduling, cost estimating, procurement, training, and human resources. Other core business functions are managed by or dependent on Project Hanford Management Contractors including, but not limited to, payroll, benefits and pension administration, inventory control, accounts payable, and records management. In addition, CHG has business relationships with its parent company CH2M HILL, U.S. Department of Energy, Office of River Protection and other River Protection Project contractors, government agencies, and vendors. The Business Systems Planning (BSP) Project, under the sponsorship of the CH2M HILL Hanford Group, Inc. Chief Information Officer (CIO), have recommended information system solutions that will support CHG business areas. The Preliminary System Design was developed using the recommendations from the Alternatives Analysis, RPP-6499, Rev 0 and will become the design base for any follow-on implementation projects. The Preliminary System Design will present a high-level system design, providing a high-level overview of the Commercial-Off-The-Shelf (COTS) modules and identify internal and external relationships. This document will not define data structures, user interface components (screens, reports, menus, etc.), business rules or processes. These in-depth activities will be accomplished at implementation planning time

  1. KALIMER fuel system preliminary design description

    International Nuclear Information System (INIS)

    Hwang, Woan; Lee, B.O.; Nam, C.; Paek, S.K.

    1998-10-01

    This document provides general design concepts, design basis, preliminary design specification and design technologies which are needed for designing the fuel/non-fuel rods and assembly ducts of the KALIMER fuel system. The core of LMFBR consists of driver fuel assembly, blanket assembly, reflector assembly, shielding assembly, control assembly and GEM (Gas Expansion Module) as well as USS, dummy assembly, detector assembly. These core components must be designed to withstand the high temperature, high flux for a long irradiation exposure time. Due to the high temperature and high flux, irradiation creep and swelling as well as thermal-mechanical deformation are occurred at the fuel/non-fuel system and cause the deformations of materials and the geometric deflections at fuel/non-fuel rods, assembly ducts and components. In order to overcome these intricate phenomena through the engineering design, the design basis including theoretical analysis methodologies and design considerations, material characteristics of fuel system, and the specifications and drawings of fuel/non-fuel rods and assembly ducts, respectively, are presented. This document is preliminary design description which is produced in the conceptual design stage, and does not present the detailed and finalized design data which can be for the manufacturing. (author). 22 refs

  2. Criteria design of the CAREM 25 reactor's core: neutronic aspects

    International Nuclear Information System (INIS)

    Lecot, C.A.

    1990-01-01

    The criteria that guided the design, from the neutronic point of view, of the CAREM reactor's core were presented. The minimum set of objectives and general criteria which permitted the design of the particular systems constituting the CAREM 25 reactor's core is detailed and stated. (Author) [es

  3. TMI-2 core examination

    International Nuclear Information System (INIS)

    Hobbins, R.R.; MacDonald, P.E.; Owen, D.E.

    1983-01-01

    The examination of the damaged core at the Three Mile Island Unit 2 (TMI-2) reactor is structured to address the following safety issues: fission product release, transport, and deposition; core coolability; containment integrity; and recriticality during severe accidents; as well as zircaloy cladding ballooning and oxidation during so-called design basis accidents. The numbers of TMI-2 components or samples to be examined, the priority of each examination, the safety issue addressed by each examination, the principal examination techniques to be employed, and the data to be obtained and the principal uses of the data are discussed in this paper

  4. Superconducting tin core fiber

    International Nuclear Information System (INIS)

    Homa, Daniel; Liang, Yongxuan; Hill, Cary; Kaur, Gurbinder; Pickrell, Gary

    2015-01-01

    In this study, we demonstrated superconductivity in a fiber with a tin core and fused silica cladding. The fibers were fabricated via a modified melt-draw technique and maintained core diameters ranging from 50-300 microns and overall diameters of 125-800 microns. Superconductivity of this fiber design was validated via the traditional four-probe test method in a bath of liquid helium at temperatures on the order of 3.8 K. The synthesis route and fiber design are perquisites to ongoing research dedicated all-fiber optoelectronics and the relationships between superconductivity and the material structures, as well as corresponding fabrication techniques. (orig.)

  5. Nuclear core catchers

    International Nuclear Information System (INIS)

    Golden, M.P.; Tilbrook, R.W.; Heylmun, N.F.

    1976-01-01

    A receptacle is described for taking the molten fragments of a nuclear reactor during a reactor core fusion accident. The receptacle is placed under the reactor. It includes at least one receptacle for the reactor core fragments, with a dome shaped part to distribute the molten fragments and at least one outside layer of alumina bricks around the dome. The characteristic of this receptacle is that the outer layer of bricks contains neutron poison rods which pass through the bricks and protrude in relation to them [fr

  6. Organizing Core Tasks

    DEFF Research Database (Denmark)

    Boll, Karen

    has remained much the same within the last 10 years. However, how the core task has been organized has changed considerable under the influence of various “organizing devices”. The paper focusses on how organizing devices such as risk assessment, output-focus, effect orientation, and treatment...... projects influence the organization of core tasks within the tax administration. The paper shows that the organizational transformations based on the use of these devices have had consequences both for the overall collection of revenue and for the employees’ feeling of “making a difference”. All in all...

  7. GREEN CORE HOUSE

    Directory of Open Access Journals (Sweden)

    NECULAI Oana

    2017-05-01

    Full Text Available The Green Core House is a construction concept with low environmental impact, having as main central element a greenhouse. The greenhouse has the innovative role to use the biomass energy provided by plants to save energy. Although it is the central piece, the greenhouse is not the most innovative part of the Green Core House, but the whole building ensemble because it integrates many other sustainable systems as "waste purification systems", "transparent photovoltaic panels" or "double skin façades".

  8. PWR core design calculations

    Energy Technology Data Exchange (ETDEWEB)

    Trkov, A; Ravnik, M; Zeleznik, N [Inst. Jozef Stefan, Ljubljana (Slovenia)

    1992-07-01

    Functional description of the programme package Cord-2 for PWR core design calculations is presented. Programme package is briefly described. Use of the package and calculational procedures for typical core design problems are treated. Comparison of main results with experimental values is presented as part of the verification process. (author) [Slovenian] Opisali smo programski paket CORD-2, ki se uporablja pri projektnih izracunih sredice pri upravljanju tlacnovodnega reaktorja. Prikazana je uporaba paketa in racunskih postopkov za tipicne probleme, ki nastopajo pri projektiranju sredice. Primerjava glavnih rezultatov z eksperimentalnimi vrednostmi je predstavljena kot del preveritvenega procesa. (author)

  9. Evaluating nuclear physics inputs in core-collapse supernova models

    Science.gov (United States)

    Lentz, E.; Hix, W. R.; Baird, M. L.; Messer, O. E. B.; Mezzacappa, A.

    Core-collapse supernova models depend on the details of the nuclear and weak interaction physics inputs just as they depend on the details of the macroscopic physics (transport, hydrodynamics, etc.), numerical methods, and progenitors. We present preliminary results from our ongoing comparison studies of nuclear and weak interaction physics inputs to core collapse supernova models using the spherically-symmetric, general relativistic, neutrino radiation hydrodynamics code Agile-Boltztran. We focus on comparisons of the effects of the nuclear EoS and the effects of improving the opacities, particularly neutrino--nucleon interactions.

  10. A 350 MW HTR with an annular pebble bed core

    International Nuclear Information System (INIS)

    Wang Dazhong; Jiang Zhiqiang; Gao Zuying; Xu Yuanhui

    1992-12-01

    A conceptual design of HTR-module with an annular pebble bed core was proposed. This design can increase the unit power capacity of HTR-Module from 200 MWt to 350 MWt while it can keep the inherent safety characteristics of modular reactor. The preliminary safety analysis results for 350 MW HTR are given. In order to solve the problem of uneven helium outlet temperature distribution a gas flow mixing structure at bottom of core was designed. The experiment results of a gas mixing simulation test rig show that the mixing function can satisfy the design requirements

  11. Core power capability verification for PWR NPP

    International Nuclear Information System (INIS)

    Xian Chunyu; Liu Changwen; Zhang Hong; Liang Wei

    2002-01-01

    The Principle and methodology of pressurized water reactor nuclear power plant core power capability verification for reload are introduced. The radial and axial power distributions of normal operation (category I or condition I) and abnormal operation (category II or condition II) are simulated by using neutronics calculation code. The linear power density margin and DNBR margin for both categories, which reflect core safety, are analyzed from the point view of reactor physics and T/H, and thus category I operating domain and category II protection set point are verified. Besides, the verification results of reference NPP are also given

  12. Maximum stellar iron core mass

    Indian Academy of Sciences (India)

    An analytical method of estimating the mass of a stellar iron core, just prior to core collapse, is described in this paper. The method employed depends, in part, upon an estimate of the true relativistic mass increase experienced by electrons within a highly compressed iron core, just prior to core collapse, and is significantly ...

  13. Nuclear core baffling apparatus

    International Nuclear Information System (INIS)

    Cooper, F.W. Jr.; Silverblatt, B.L.; Knight, C.B.; Berringer, R.T.

    1979-01-01

    An apparatus for baffling the flow of reactor coolant fluid into and about the core of a nuclear reactor is described. The apparatus includes a plurality of longitudinally aligned baffle plates with mating surfaces that allow longitudinal growth with temperature increases while alleviating both leakage through the aligned plates and stresses on the components supporting the plates

  14. The Uncommon Core

    Science.gov (United States)

    Ohler, Jason

    2013-01-01

    This author contends that the United States neglects creativity in its education system. To see this, he states, one may look at the Common Core State Standards. If one searches the English Language Arts and Literacy standards for the words "creative," "innovative," and "original"--and any associated terms, one will…

  15. Utah's New Mathematics Core

    Science.gov (United States)

    Utah State Office of Education, 2011

    2011-01-01

    Utah has adopted more rigorous mathematics standards known as the Utah Mathematics Core Standards. They are the foundation of the mathematics curriculum for the State of Utah. The standards include the skills and understanding students need to succeed in college and careers. They include rigorous content and application of knowledge and reflect…

  16. Some Core Contested Concepts

    Science.gov (United States)

    Chomsky, Noam

    2015-01-01

    Core concepts of language are highly contested. In some cases this is legitimate: real empirical and conceptual issues arise. In other cases, it seems that controversies are based on misunderstanding. A number of crucial cases are reviewed, and an approach to language is outlined that appears to have strong conceptual and empirical motivation, and…

  17. Reactor core structure

    International Nuclear Information System (INIS)

    Higashinakagawa, Emiko; Sato, Kanemitsu.

    1992-01-01

    Taking notice on the fact that Fe based alloys and Ni based alloys are corrosion resistant in a special atmosphere of a nuclear reactor, Fe or Ni based alloys are applied to reactor core structural components such as fuel cladding tubes, fuel channels, spacers, etc. On the other hand, the neutron absorption cross section of zirconium is 0.18 barn while that of iron is 2.52 barn and that of nickel is 4.6 barn, which amounts to 14 to 25 times compared with that of zirconium. Accordingly, if the reactor core structural components are constituted by the Fe or Ni based alloys, neutron economy is lowered. Since it is desirable that neutrons contribute to uranium fission with least absorption to the reactor core structural components, the reactor core structural components are constituted with the Fe or Ni based alloys of good corrosion resistance only at a portion in contact with reactor water, that is, at a surface portion, while the main body is constituted with zircalloy in the present invention. Accordingly, corrosion resistnace can be kept while keeping small neutron absorption cross section. (T.M.)

  18. Investigation of EAS cores

    Directory of Open Access Journals (Sweden)

    Shaulov S.B.

    2017-01-01

    Full Text Available The development of nuclear-electromagnetic cascade models in air in the late forties have shown informational content of the study of cores of extensive air showers (EAS. These investigations were the main goal in different experiments which were carried out over many years by a variety of methods. Outcomes of such investigations obtained in the HADRON experiment using an X-ray emulsion chamber (XREC as a core detector are considered. The Ne spectrum of EAS associated with γ-ray families, spectra of γ-rays (hadrons in EAS cores and the Ne dependence of the muon number, ⟨Nμ⟩, in EAS with γ-ray families are obtained for the first time at energies of 1015–1017 eV with this method. A number of new effects were observed, namely, an abnormal scaling violation in hadron spectra which are fundamentally different from model predictions, an excess of muon number in EAS associated with γ-ray families, and the penetrating component in EAS cores. It is supposed that the abnormal behavior of γ-ray spectra and Ne dependence of the muon number are explained by the emergence of a penetrating component in the 1st PCR spectrum ‘knee’ range. Nuclear and astrophysical explanations of the origin of the penetrating component are discussed. The necessity of considering the contribution of a single close cosmic-ray source to explain the PCR spectrum in the knee range is noted.

  19. Plutonium cores of zenith

    Energy Technology Data Exchange (ETDEWEB)

    Barclay, F R; Cameron, I R; Drageset, A; Freemantle, R G; Wilson, D J

    1965-03-15

    The report describes a series of experiments carried out with plutonium fuel in the heated zero power reactor ZENITH, with the aim of testing current theoretical methods, with particular reference to excess reactivity, temperature coefficients, differential spectrum and reaction rate distributions. Two cores of widely different fissile/moderator atom ratios were loaded in order to test the theory under significantly varied spectrum conditions.

  20. Core damage risk indicators

    International Nuclear Information System (INIS)

    Szikszai, T.

    1994-01-01

    The purpose of this document is to show a method for the fast recalculation of the PSA. To avoid the information loose, it is necessary to simplify the PSA models, or at least reorganize them. The method, introduced in this document, require that preparation, so we try to show, how to do that. This document is an introduction. This is the starting point of the work related to the development of the risk indicators. In the future, with the application of this method, we are going to show an everyday use of the PSA results to produce the indicators of the core damage risk. There are two different indicators of the plant safety performance, related to the core damage risk. The first is the core damage frequency indicator (CDFI), and the second is the core damage probability indicator (CDPI). Of course, we cannot describe all of the possible ways to use these indicators, rather we will try to introduce the requirements to establish such an indicator system and the calculation process

  1. Core calculations of JMTR

    Energy Technology Data Exchange (ETDEWEB)

    Nagao, Yoshiharu [Japan Atomic Energy Research Inst., Oarai, Ibaraki (Japan). Oarai Research Establishment

    1998-03-01

    In material testing reactors like the JMTR (Japan Material Testing Reactor) of 50 MW in Japan Atomic Energy Research Institute, the neutron flux and neutron energy spectra of irradiated samples show complex distributions. It is necessary to assess the neutron flux and neutron energy spectra of an irradiation field by carrying out the nuclear calculation of the core for every operation cycle. In order to advance core calculation, in the JMTR, the application of MCNP to the assessment of core reactivity and neutron flux and spectra has been investigated. In this study, in order to reduce the time for calculation and variance, the comparison of the results of the calculations by the use of K code and fixed source and the use of Weight Window were investigated. As to the calculation method, the modeling of the total JMTR core, the conditions for calculation and the adopted variance reduction technique are explained. The results of calculation are shown. Significant difference was not observed in the results of neutron flux calculations according to the difference of the modeling of fuel region in the calculations by K code and fixed source. The method of assessing the results of neutron flux calculation is described. (K.I.)

  2. Emergency core cooling system

    International Nuclear Information System (INIS)

    Kato, Ken.

    1989-01-01

    In PWR type reactors, a cooling water spray portion of emergency core cooling pipelines incorporated into pipelines on high temperature side is protruded to the inside of an upper plenum. Upon rupture of primary pipelines, pressure in a pressure vessel is abruptly reduced to generate a great amount of steams in the reactor core, which are discharged at a high flow rate into the primary pipelines on high temperature side. However, since the inside of the upper plenum has a larger area and the steam flow is slow, as compared with that of the pipelines on the high temperature side, ECCS water can surely be supplied into the reactor core to promote the re-flooding of the reactor core and effectively cool the reactor. Since the nuclear reactor can effectively be cooled to enable the promotion of pressure reduction and effective supply of coolants during the period of pressure reduction upon LOCA, the capacity of the pressure accumulation vessel can be decreased. Further, the re-flooding time for the reactor is shortened to provide an effect contributing to the improvement of the safety and the reduction of the cost. (N.H.)

  3. Thermal margin model for transition core of KSNP

    International Nuclear Information System (INIS)

    Nahm, Kee Yil; Lim, Jong Seon; Park, Sung Kew; Chun, Chong Kuk; Hwang, Sun Tack

    2004-01-01

    The PLUS7 fuel was developed with mixing vane grids for KSNP. For the transition core partly loaded with the PLUS7 fuels, the procedure to set up the optimum thermal margin model of the transition core was suggested by introducing AOPM concept into the screening method which determines the limiting assembly. According to the procedure, the optimum thermal margin model of the first transition core was set up by using a part of nuclear data for the first transition and the homogeneous core with PLUS7 fuels. The generic thermal margin model of PLUS7 fuel was generated with the AOPM of 138%. The overpower penalties on the first transition core were calculated to be 1.0 and 0.98 on the limiting assembly and the generic thermal margin model, respectively. It is not usual case to impose the overpower penalty on reload cores. It is considered that the lack of channel flow due to the difference of pressure drop between PLUS7 and STD fuels results in the decrease of DNBR. The AOPM of the first transition core is evaluated to be about 135% by using the optimum generic thermal margin model which involves the generic thermal margin model and the total overpower penalty. The STD fuel is not included among limiting assembly candidates in the second transition core, because they have much lower pin power than PLUS7 fuels. The reduced number of STD fuels near the limiting assembly candidates the flow from the limiting assembly to increase the thermal margin for the second transition core. It is expected that cycle specific overpower penalties increase the thermal margin for the transition core. Using the procedure to set up the optimum thermal margin model makes sure that the enhanced thermal margin of PLUS7 fuel can be sufficiently applied to not only the homogeneous core but also the transition core

  4. Scaling laws for HTGR core block seismic response

    International Nuclear Information System (INIS)

    Dove, R.C.

    1977-01-01

    This paper discusses the development of scaling laws, physical modeling, and seismic testing of a model designed to represent a High Temperature Gas-Cooled Reactor (HTGR) core consisting of graphite blocks. The establishment of the proper scale relationships for length, time, force, and other parameters is emphasized. Tests to select model materials and the appropriate scales are described. Preliminary results obtained from both model and prototype systems tested under simulated seismic vibration are presented

  5. Multidimensional, multiphysics simulations of core-collapse supernovae

    Energy Technology Data Exchange (ETDEWEB)

    Messer, O E B [National Center for Computational Sciences, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6008 (United States); Bruenn, S W [Department of Physics, Florida Atlantic University, Boca Raton, FL 33431-0991 (United States); Blondin, J M [Department of Physics, North Carolina State University, Raleigh, NC 27695-8202 (United States); Hix, W R; Mezzacappa, A [Physics Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6354 (United States)

    2008-07-15

    CHIMERA is a multi-dimensional radiation hydrodynamics code designed to study core-collapse supernovae. The code is made up of three essentially independent parts: a hydrodynamics module, a nuclear burning module, and a neutrino transport solver combined within an operator-split approach. We review the code's architecture and some recently improved implementations used in the code. We also briefly discuss preliminary results obtained with the code in three spatial dimensions.

  6. Inflation targeting and core inflation

    OpenAIRE

    Julie Smith

    2005-01-01

    This paper examines the interaction of core inflation and inflation targeting as a monetary policy regime. Interest in core inflation has grown because of inflation targeting. Core inflation is defined in numerous ways giving rise to many potential measures; this paper defines core inflation as the best forecaster of inflation. A cross-country study finds before the start of inflation targeting, but not after, core inflation differs between non-inflation targeters and inflation targeters. Thr...

  7. CORE annual report 2006; CORE Jahresbericht 2006

    Energy Technology Data Exchange (ETDEWEB)

    Gut, A

    2007-04-15

    This annual report for the Swiss Federal Office of Energy (SFOE) summarises the activities of the Swiss Federal Commission on Energy Research CORE in 2006. The six main areas of work during the period 2004 - 2007 are examined, including a review of the SFOE's energy research programme, a road-map for the way towards the realisation of a 2000-watt society, the formulation of an energy research concept for 2008 - 2011, international co-operation, the dissemination of information and the assessment of existing and new instruments. International activities and Switzerland's involvement in energy research within the framework of the International Energy Agency IEA are discussed. New and existing projects are listed and the work done at the Competence Centre for Energy and Mobility noted. The Swiss Technology Award 2007 is presented. Information supplied to interested bodies to help improve knowledge on research work being done and to help make discussions on future energy supply more objective is discussed.

  8. The whole-core LEU fuel demonstration in the ORR

    International Nuclear Information System (INIS)

    Snelgrove, J.L.; Bretscher, M.M.; Cornella, R.J.; Hobbs, R.W.

    1985-01-01

    A whole-core demonstration of LEU fuel in the ORR is expected to begin during November 1985. Fuel elements will contain U 3 Si 2 at 4.8 Mg U/m 3 and shim rod fuel followers will contain U 3 Si 2 at 3.5 Mg U/m 3 . Fuel fabrication is underway at B and W, CERCA, and NUKEM, with shipments scheduled to commence in October. The primary objectives of the demonstration are to provide data for validation of LEU and mixed-core fuel cycle calculations and to provide a large-scale demonstration of the acceptable performance of production-line U 3 Si 2 fuel elements. It is planned to approach the full LEU core through a series of mixed cores. Measurements to be made include flux distribution, reactivity swing, control rod worth, cycle length, fuel discharge burn-up, gamma heating rate, β eff /l, and isothermal temperature coefficient. Measurements will also be made on fresh LEU and fresh HEU critical configurations. Preliminary safety approval has been received and the final safety assessment is being reviewed. Key issues being addressed in the safety assessment are fuel performance, radiological consequences, margin to burnout and transient behavior. The LEU core is comparable in all safety aspects to the HEU core and the transition core is only marginally worse owing to higher power seeking factors. (author)

  9. SCDAP/RELAP5 lower core plate model

    International Nuclear Information System (INIS)

    Coryell, E.W.; Griffin, F.P.

    1999-01-01

    The SCDAP/RELAP5 computer code is a best-estimate analysis tool for performing nuclear reactor severe accident simulations. This report describes the justification, theory, implementation, and testing of a new modeling capability which will refine the analysis of the movement of molten material from the core region to the vessel lower head. As molten material moves from the core region through the core support structures it may encounter conditions which will cause it to freeze in the region of the lower core plate, delaying its arrival to the vessel head. The timing of this arrival is significant to reactor safety, because during the time span for material relocation to the lower head, the core may be experiencing steam-limited oxidation. The time at which hot material arrives in a coolant-filled lower vessel head, thereby significantly increasing the steam flow rate through the core region, becomes significant to the progression and timing of a severe accident. This report is a revision of a report INEEL/EXT-00707, entitled ''Preliminary Design Report for SCDAP/RELAP5 Lower Core Plate Model''

  10. Analysis of the seismic response of a fast reactor core

    International Nuclear Information System (INIS)

    Martelli, A.; Maresca, G.

    1984-01-01

    This report deals with the methods to apply for a correct evaluation of the reactor core seismic response. Reference is made to up-to-date design data concerning the PEC core, taking into account the presence of the core-restraint plate located close to the PEC core elements top and applying the optimized iterative procedure between the vessel linear calculation and the non-linear ones limited to the core, which had been described in a previous report. It is demonstrated that the convergence of this procedure is very fast, similar to what obtained in the calculations of the cited report, carried out with preliminary data, and it is shown that the cited methods allow a reliable evaluation of the excitation time histories for the experimental tests in support of the seismic verification of the shutdown system and the core of a fast reactor, as well as relevant data for the experimental, structural and functional, verification of the core elements in the case of seismic loads

  11. Development of in-core measuring method using optical techniques

    International Nuclear Information System (INIS)

    Kakuta, Tsunemi; Shikama, Tatsuo; Narui, Minoru; Sagawa, Tsutomu.

    1994-01-01

    Since applying to more severe radiation environments in nuclear plants, e.g., in-core measuring systems, diagnostics for fusion reactors, radiation related subjects should be considered by more severe radiation and environmental conditions. Owing to this, preliminary studies of heavy neutron irradiation effects on optical fibers are conducted in the core region of fission reactor. Two kinds of SiO 2 core optical fibers, highly pure SiO 2 with OH content core and SiO 2 with fluorine doped core, were irradiated in the core region of Japan Material Testing Reactor (JMTR). Both fibers were irradiated with fast neutron (E>1.0 MeV) fluence of about 1.6x10 19 n/cm 2 and gamma-ray doses of 3.3x10 9 Gy. The optical absorption and the light-emission spectrum were measured in-situ along the irradiation. This paper mainly outlines the fundamental effects of neutron irradiation and discuss the possibility of neutron detection in the core region of reactor. (J.P.N.)

  12. A multi-crucible core-catcher concept: Design considerations and basic results

    International Nuclear Information System (INIS)

    Szabo, I.

    1995-01-01

    A multi-crucible core-catcher concept to be implemented in new light water reactor containments has recently been proposed. This paper deals with conceptual design considerations and the various ways this type of core-catcher could be designed to meet requirements for reactor application. A systematic functional analysis of the multi-crucible core-catcher concept and the results of the preliminary design calculation are presented. Finally, the adequacy of the multi-crucible core-catcher concept for reactor application is discussed. (orig.)

  13. Effects of the vessel core seismic interaction for a fast reactor

    International Nuclear Information System (INIS)

    Martelli, A.; Maresca, G.

    1983-01-01

    This report describes the features and the results of the analysis carried out in collaboration between ENEA and NIRA for evaluating the effects of the vessel core dynamic interaction in case of safe shutdown earthquake, both in absence and in presence of one or two restraint plates inserted in the tank close to the middle and or top planes for limiting the core seismic motion. Such analysis, although carried out making use of preliminary data, contributed to the recent ENEA decision of applying a core restraint close to the core element top

  14. Preliminary results of the XR2-1 experiment

    International Nuclear Information System (INIS)

    Gauntt, R.O.; Helmick, P.H.; Humphries, L.

    1996-01-01

    The XR2-1 (Ex-Reactor) experiment, investigating metallic core-melt relocation in boiling water reactor geometry, was performed on October 12, 1995, following two previous simpler XR1-series tests in August and November of 1993. The XR2-1 test made use of a highly detailed replication of the lower region of the BWR core, including the control blade and channel box structures, fuel rods, fuel canister nosepieces, control blade velocity limiter, and fuel support pieces, in order to investigate a key core melt progression uncertainty for BWR Station Blackout type accidents. The purpose of this experiment program is to examine the behavior of downward-draining molten metallic core materials in a severe reactor accident in a dry BWR core, and to determine conditions under which the molten materials drain out of the core region, or freeze to form blockages in the lower portion of the core. In the event that the draining metallic materials do not form stable blockages in the lower core region, and instead erode the lower core structures such as the lower core plate, then the subsequent core melt progression processes may proceed quite differently than was observed in the TMI-2 accident, with correspondingly different impact on vessel loading and vessel release behavior. The results of the Ex-Reactor tests are preliminary. All of the tests conducted have shown a significant degree of channel box destruction induced by the draining control blade materials. The XR2-1 test further showed that the draining zircaloy melt causes significant disruption of the fuel rod geometry. All of the tests have shown tendencies to form interim blockages as the melts temporarily freeze, but that these blockages re-melt, assisted by eutectic interactions, resulting in the sudden draining of accumulated metallic melt pools

  15. Setting a personal career direction.

    Science.gov (United States)

    McCurdy, Fredrick A; Marcdante, Karen

    2003-01-01

    In summary, we believe that both you and your organization should have a set of core values, a well-defined mission (core purpose), and a vision of the future. Ideally, your projects and activities should be congruent with your mission and values, you should be pursuing your vision, and all of this should be congruent with the organization mission and values. Practically speaking, most individuals we have worked with over the years find themselves in two different groups at this point in the exercise. The minority find that their personal mission is not at all similar to the mission of their current organization and they find it necessary to seriously reevaluate their personal career direction. Sometimes, this results in them finding some other place to work. On the other hand, the majority discover their personal mission is in reasonable agreement with that of their organization. For both, this exercise has helped them clarify and better manage their personal career direction.

  16. Proposal of a benchmark for core burnup calculations for a VVER-1000 reactor core

    International Nuclear Information System (INIS)

    Loetsch, T.; Khalimonchuk, V.; Kuchin, A.

    2009-01-01

    In the framework of a project supported by the German BMU the code DYN3D should be further validated and verified. During the work a lack of a benchmark on core burnup calculations for VVER-1000 reactors was noticed. Such a benchmark is useful for validating and verifying the whole package of codes and data libraries for reactor physics calculations including fuel assembly modelling, fuel assembly data preparation, few group data parametrisation and reactor core modelling. The benchmark proposed specifies the core loading patterns of burnup cycles for a VVER-1000 reactor core as well as a set of operational data such as load follow, boron concentration in the coolant, cycle length, measured reactivity coefficients and power density distributions. The reactor core characteristics chosen for comparison and the first results obtained during the work with the reactor physics code DYN3D are presented. This work presents the continuation of efforts of the projects mentioned to estimate the accuracy of calculated characteristics of VVER-1000 reactor cores. In addition, the codes used for reactor physics calculations of safety related reactor core characteristics should be validated and verified for the cases in which they are to be used. This is significant for safety related evaluations and assessments carried out in the framework of licensing and supervision procedures in the field of reactor physics. (authors)

  17. Core elements of physiotherapy in cerebral palsy children: proposal for a trial checklist.

    Science.gov (United States)

    Meghi, P; Rossetti, L; Corrado, C; Maran, E; Arosio, N; Ferrari, A

    2012-03-01

    Currently international literature describes physiotherapy in cerebral palsy (CP) children only in generic terms (traditional / standard / background / routine). The aim of this study is to create a checklist capable of describing the different modalities employed in physiotherapeutic treatment by means of a non-bias, common, universal, standardised language. A preliminary checklist was outlined by a group of physiotherapists specialised in child rehabilitation. For its experimentation, several physiotherapists from various paediatric units from all over Italy with different methodological approaches and backgrounds, were involved. Using the interpretative model, proposed by Ferrari et al., and through collective analysis and discussion of clinical videos, the core elements were progressively selected and codified. A reliability study was then carried out by eight expert physiotherapists using an inter-rate agreement model. The checklist analyses therapeutic proposals of CP rehabilitation through the description of settings, exercises and facilitations and consists of items and variables which codify all possible physiotherapeutic interventions. It is accompanied by written explanations, demonstrative videos, caregiver interviews and descriptions of applied environmental adaptations. All checklist items obtained a high level of agreement (according to Cohen's kappa coefficient), revealing that the checklist is clearly and easily interpretable. The checklist should facilitate interaction and communication between specialists and families, and lead to comparable research studies and scientific advances. The main value is to be able to correlate therapeutic results with core elements of adopted physiotherapy.

  18. Design review report for the hydrogen interlock preliminary design

    International Nuclear Information System (INIS)

    Corbett, J.E.

    1996-01-01

    This report documents the completion of a preliminary design review for the hydrogen interlock. The hydrogen interlock, a proposed addition to the Rotary Mode Core Sampling (RMCS) system portable exhauster, is intended to support core sampling operations in waste tanks requiring flammable gas controls. The objective of this review was to validate basic design assumptions and concepts to support a path forward leading to a final design. The conclusion reached by the review committee was that the design was acceptable and efforts should continue toward a final design review

  19. New radiofrequency device to reduce bleeding after core needle biopsy: Experimental study in a porcine liver model

    International Nuclear Information System (INIS)

    Lim, Sang Hyeok; Rhim, Hyun Chul; Lee, Min Woo; Song, Kyoung Doo; Kang, Tae Wook; Kim, Young Sun; Lim, Hyo Keun

    2017-01-01

    To evaluate the in vivo efficiency of the biopsy tract radiofrequency ablation for hemostasis after core biopsy of the liver in a porcine liver model, including situations with bleeding tendency and a larger (16-gauge) core needle. A preliminary study was performed using one pig to determine optimal ablation parameters. For the main experiment, four pigs were assigned to different groups according to heparinization use and biopsy needle caliber. In each pig, 14 control (without tract ablation) and 14 experimental (tract ablation) ultrasound-guided core biopsies were performed using either an 18- or 16-gauge needle. Post-biopsy bleeding amounts were measured by soaking up the blood for five minutes. The results were compared using the Mann-Whitney U test. The optimal parameters for biopsy tract ablation were determined as a 2-cm active tip electrode set at 40-watt with a tip temperature of 70–80℃. The bleeding amounts in all experimental groups were smaller than those in the controls; however they were significant in the non-heparinized pig biopsied with an 18-gauge needle and in two heparinized pigs (p < 0.001). In the heparinized pigs, the mean blood loss in the experimental group was 3.5% and 13.5% of the controls biopsied with an 18- and 16-gauge needle, respectively. Radiofrequency ablation of hepatic core biopsy tract ablation may reduce post-biopsy bleeding even under bleeding tendency and using a larger core needle, according to the result from in vivo porcine model experiments

  20. New radiofrequency device to reduce bleeding after core needle biopsy: Experimental study in a porcine liver model

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Sang Hyeok; Rhim, Hyun Chul; Lee, Min Woo; Song, Kyoung Doo; Kang, Tae Wook; Kim, Young Sun; Lim, Hyo Keun [Dept. of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2017-01-15

    To evaluate the in vivo efficiency of the biopsy tract radiofrequency ablation for hemostasis after core biopsy of the liver in a porcine liver model, including situations with bleeding tendency and a larger (16-gauge) core needle. A preliminary study was performed using one pig to determine optimal ablation parameters. For the main experiment, four pigs were assigned to different groups according to heparinization use and biopsy needle caliber. In each pig, 14 control (without tract ablation) and 14 experimental (tract ablation) ultrasound-guided core biopsies were performed using either an 18- or 16-gauge needle. Post-biopsy bleeding amounts were measured by soaking up the blood for five minutes. The results were compared using the Mann-Whitney U test. The optimal parameters for biopsy tract ablation were determined as a 2-cm active tip electrode set at 40-watt with a tip temperature of 70–80℃. The bleeding amounts in all experimental groups were smaller than those in the controls; however they were significant in the non-heparinized pig biopsied with an 18-gauge needle and in two heparinized pigs (p < 0.001). In the heparinized pigs, the mean blood loss in the experimental group was 3.5% and 13.5% of the controls biopsied with an 18- and 16-gauge needle, respectively. Radiofrequency ablation of hepatic core biopsy tract ablation may reduce post-biopsy bleeding even under bleeding tendency and using a larger core needle, according to the result from in vivo porcine model experiments.

  1. Goal-setting in multidisciplinary team care for patients with rheumatoid arthritis

    DEFF Research Database (Denmark)

    Meesters, Jorit; Hagel, Sofia; Klokkerud, Mari

    2013-01-01

    %) to "Environmental Factors" (e-codes). Thirty-five of the 151 unique ICF codes (23%) were not in the comprehensive ICF Core Set for RA, whereas 23 of the ICF codes in this Core Set (24%) were not in the rehabilitation goals. Conclusion: The goals set in a team rehabilitation setting for patients with rheumatoid...

  2. The application of mechanical desktop in the design of the reactor core structure of China advanced research reactor

    International Nuclear Information System (INIS)

    Lang Ruifeng

    2002-01-01

    The three-dimensional parameterization design method is introduced to the design of reactor core structure for China advanced research reactor. Based on the modeling and dimension variable driving of the main parts as well as the modification of dimension variable, the preliminary design and modification of reactor core is carried out with high design efficiency and quality as well as short periods

  3. Ice cores and palaeoclimate

    International Nuclear Information System (INIS)

    Krogh Andersen, K.; Ditlevsen, P.; Steffensen, J.P.

    2001-01-01

    Ice cores from Greenland give testimony of a highly variable climate during the last glacial period. Dramatic climate warmings of 15 to 25 deg. C for the annual average temperature in less than a human lifetime have been documented. Several questions arise: Why is the Holocene so stable? Is climatic instability only a property of glacial periods? What is the mechanism behind the sudden climate changes? Are the increased temperatures in the past century man-made? And what happens in the future? The ice core community tries to attack some of these problems. The NGRIP ice core currently being drilled is analysed in very high detail, allowing for a very precise dating of climate events. It will be possible to study some of the fast changes on a year by year basis and from this we expect to find clues to the sequence of events during rapid changes. New techniques are hoped to allow for detection of annual layers as far back as 100,000 years and thus a much improved time scale over past climate changes. It is also hoped to find ice from the Eemian period. If the Eemian layers confirm the GRIP sequence, the Eemian was actually climatically unstable just as the glacial period. This would mean that the stability of the Holocene is unique. It would also mean, that if human made global warming indeed occurs, we could jeopardize the Holocene stability and create an unstable 'Eemian situation' which ultimately could start an ice age. Currenlty mankind is changing the composition of the atmosphere. Ice cores document significant increases in greenhouse gases, and due to increased emissions of sulfuric and nitric acid from fossil fuel burning, combustion engines and agriculture, modern Greenland snow is 3 - 5 times more acidic than pre-industrial snow (Mayewski et al., 1986). However, the magnitude and abruptness of the temperature changes of the past century do not exceed the magnitude of natural variability. It is from the ice core perspective thus not possible to attribute the

  4. UVISS preliminary visibility analysis

    DEFF Research Database (Denmark)

    Betto, Maurizio

    1998-01-01

    The goal of this work is to obtain a preliminary assessment of the sky visibility for anastronomical telescope located on the express pallet of the International SpaceStation (ISS)} taking into account the major constraints imposed on the instrument by the ISSattitude and structure. Part of the w......The goal of this work is to obtain a preliminary assessment of the sky visibility for anastronomical telescope located on the express pallet of the International SpaceStation (ISS)} taking into account the major constraints imposed on the instrument by the ISSattitude and structure. Part...... of the work is also to setup the kernel of a software tool for the visibility analysis thatshould be easily expandable to consider more complex strucures for future activities.This analysis is part of the UVISS assessment study and it is meant to provide elementsfor the definition and the selection...

  5. On Input Vector Representation for the SVR model of Reactor Core Loading Pattern Critical Parameters

    International Nuclear Information System (INIS)

    Trontl, K.; Pevec, D.; Smuc, T.

    2008-01-01

    Determination and optimization of reactor core loading pattern is an important factor in nuclear power plant operation. The goal is to minimize the amount of enriched uranium (fresh fuel) and burnable absorbers placed in the core, while maintaining nuclear power plant operational and safety characteristics. The usual approach to loading pattern optimization involves high degree of engineering judgment, a set of heuristic rules, an optimization algorithm and a computer code used for evaluating proposed loading patterns. The speed of the optimization process is highly dependent on the computer code used for the evaluation. Recently, we proposed a new method for fast loading pattern evaluation based on general robust regression model relying on the state of the art research in the field of machine learning. We employed Support Vector Regression (SVR) technique. SVR is a supervised learning method in which model parameters are automatically determined by solving a quadratic optimization problem. The preliminary tests revealed a good potential of the SVR method application for fast and accurate reactor core loading pattern evaluation. However, some aspects of model development are still unresolved. The main objective of the work reported in this paper was to conduct additional tests and analyses required for full clarification of the SVR applicability for loading pattern evaluation. We focused our attention on the parameters defining input vector, primarily its structure and complexity, and parameters defining kernel functions. All the tests were conducted on the NPP Krsko reactor core, using MCRAC code for the calculation of reactor core loading pattern critical parameters. The tested input vector structures did not influence the accuracy of the models suggesting that the initially tested input vector, consisted of the number of IFBAs and the k-inf at the beginning of the cycle, is adequate. The influence of kernel function specific parameters (σ for RBF kernel

  6. Antares: preliminary demonstrator results

    International Nuclear Information System (INIS)

    Kouchner, A.

    2000-05-01

    The ANTARES collaboration is building an undersea neutrino telescope off Toulon (Mediterranean sea) with effective area ∼ 0.1 km 2 . An extensive study of the site properties has been achieved together with software analysis in order to optimize the performance of the detector. Results are summarized here. An instrumented line, linked to shore for first time via an electro-optical cable, has been immersed late 1999. The preliminary results of this demonstrator line are reported. (author)

  7. Birefringent hollow core fibers

    DEFF Research Database (Denmark)

    Roberts, John

    2007-01-01

    Hollow core photonic crystal fiber (HC-PCF), fabricated according to a nominally non-birefringent design, shows a degree of un-controlled birefringence or polarization mode dispersion far in excess of conventional non polarization maintaining fibers. This can degrade the output pulse in many...... applications, and places emphasis on the development of polarization maintaining (PM) HC-PCF. The polarization cross-coupling characteristics of PM HC-PCF are very different from those of conventional PM fibers. The former fibers have the advantage of suffering far less from stress-field fluctuations...... and an increased overlap between the polarization modes at the glass interfaces. The interplay between these effects leads to a wavelength for optimum polarization maintenance, lambda(PM), which is detuned from the wavelength of highest birefringence. By a suitable fiber design involving antiresonance of the core...

  8. Plasma core reactor applications

    International Nuclear Information System (INIS)

    Latham, T.S.; Rodgers, R.J.

    1976-01-01

    Analytical and experimental investigations are being conducted to demonstrate the feasibility of fissioning uranium plasma core reactors and to characterize space and terrestrial applications for such reactors. Uranium hexafluoride (UF 6 ) fuel is injected into core cavities and confined away from the surface by argon buffer gas injected tangentially from the peripheral walls. Power, in the form of thermal radiation emitted from the high-temperature nuclear fuel, is transmitted through fused-silica transparent walls to working fluids which flow in axial channels embedded in segments of the cavity walls. Radiant heat transfer calculations were performed for a six-cavity reactor configuration; each cavity is approximately 1 m in diameter by 4.35 m in length. Axial working fluid channels are located along a fraction of each cavity peripheral wall

  9. Reactor core cooling device

    International Nuclear Information System (INIS)

    Kobayashi, Masahiro.

    1986-01-01

    Purpose: To safely and effectively cool down the reactor core after it has been shut down but is still hot due to after-heat. Constitution: Since the coolant extraction nozzle is situated at a location higher than the coolant injection nozzle, the coolant sprayed from the nozzle, is free from sucking immediately from the extraction nozzle and is therefore used effectively to cool the reactor core. As all the portions from the top to the bottom of the reactor are cooled simultaneously, the efficiency of the reactor cooling process is increased. Since the coolant extraction nozzle can be installed at a point considerably higher than the coolant injection nozzle, the distance from the coolant surface to the point of the coolant extraction nozzle can be made large, preventing cavitation near the coolant extraction nozzle. Therefore, without increasing the capacity of the heat exchanger, the reactor can be cooled down after a shutdown safely and efficiently. (Kawakami, Y.)

  10. Some core contested concepts.

    Science.gov (United States)

    Chomsky, Noam

    2015-02-01

    Core concepts of language are highly contested. In some cases this is legitimate: real empirical and conceptual issues arise. In other cases, it seems that controversies are based on misunderstanding. A number of crucial cases are reviewed, and an approach to language is outlined that appears to have strong conceptual and empirical motivation, and to lead to conclusions about a number of significant issues that differ from some conventional beliefs.

  11. Schumpeter's core works revisited

    DEFF Research Database (Denmark)

    Andersen, Esben Sloth

    2012-01-01

    This paper organises Schumpeter’s core books in three groups: the programmatic duology,the evolutionaryeconomic duology,and the socioeconomic synthesis. By analysing these groups and their interconnections from the viewpoint of modern evolutionaryeconomics,the paper summarises resolved problems a...... and points at remaining challenges. Its analyses are based on distinctions between microevolution and macroevolution, between economic evolution and socioeconomic coevolution, and between Schumpeter’s three major evolutionary models (called Mark I, Mark II and Mark III)....

  12. Three Types of Earth's Inner Core Boundary

    Science.gov (United States)

    Tian, D.; Wen, L.

    2017-12-01

    The Earth's inner core boundary (ICB) is the site where the liquid outer core solidifies and the solid inner core grows. Thus, the fine-scale structure of the ICB is important for our understanding of the thermo-compositional state of the Earth's core. In this study, we collect a large set of seismic records with high-quality pre-critical PKiKP and PcP phase pairs, recorded by two dense seismic arrays, Hi-net in Japan and USArray in US. This dataset samples the ICB regions beneath East Asia, Mexico and the Bering Sea. We use differential travel times, amplitude ratios and waveform differences between PKiKP and PcP phases to constrain fine-scale structure of the ICB. The sampled ICB can be grouped into three types based on their seismic characteristics: (1) a simple ICB with a flat and sharp boundary, (2) a bumpy ICB with topographic height changes of 10 km, and (3) a localized mushy ICB with laterally varying thicknesses of 4-8 km. The laterally varying fine-scale structure of the ICB indicates existence of complex small-scale forces at the surface and a laterally varying solidification process of the inner core due to lateral variation of thermo-compositional condition near the ICB.

  13. BWR type reactor core

    International Nuclear Information System (INIS)

    Tatemichi, Shin-ichiro.

    1981-01-01

    Purpose: To eliminate the variation in the power distribution of a BWR type reactor core in the axial direction even if the flow rate is increased or decreased by providing a difference in the void coefficient between the upper part and the lower parts of the reactor core, and increasing the void coefficient at the lower part of the reactor core. Constitution: The void coefficient of the lower region from the center to the lower part along the axial direction of a nuclear fuel assembly is increased to decrease the dependence on the flow rate of the axial power distribution of the nuclear fuel assembly. That is, a water/fuel ratio is varied, the water in non-boiled region is increased or the neutron spectrum is varied so as to vary the void coefficient. In order to exemplify it, the rate of the internal pellets of the fuel rod of the nuclear fuel assembly or the shape of the channel box is varied. Accordingly, the power does not considerably vary even if the flow rate is altered since the power is varied in the power operation. (Yoshihara, H.)

  14. Emergency core cooling system

    International Nuclear Information System (INIS)

    Ando, Masaki.

    1987-01-01

    Purpose: To actuate an automatic pressure down system (ADS) and a low pressure emergency core cooling system (ECCS) upon water level reduction of a nuclear reactor other than loss of coolant accidents (LOCA). Constitution: ADS in a BWR type reactor is disposed for reducing the pressure in a reactor container thereby enabling coolant injection from a low pressure ECCS upon LOCA. That is, ADS has been actuated by AND signal for a reactor water level low signal and a dry well pressure high signal. In the present invention, ADS can be actuated further also by AND signal of the reactor water level low signal, the high pressure ECCS and not-operation signal of reactor isolation cooling system. In such an emergency core cooling system thus constituted, ADS operates in the same manner as usual upon LOCA and, further, ADS is operated also upon loss of feedwater accident in the reactor pressure vessel in the case where there is a necessity for actuating the low pressure ECCS, although other high pressure ECCS and reactor isolation cooling system are not operated. Accordingly, it is possible to improve the reliability upon reactor core accident and mitigate the operator burden. (Horiuchi, T.)

  15. Preliminary conceptual design and analysis on KALIMER reactor structures

    International Nuclear Information System (INIS)

    Kim, Jong Bum

    1996-10-01

    The objectives of this study are to perform preliminary conceptual design and structural analyses for KALIMER (Korea Advanced Liquid Metal Reactor) reactor structures to assess the design feasibility and to identify detailed analysis requirements. KALIMER thermal hydraulic system analysis results and neutronic analysis results are not available at present, only-limited preliminary structural analyses have been performed with the assumptions on the thermal loads. The responses of reactor vessel and reactor internal structures were based on the temperature difference of core inlet and outlet and on engineering judgments. Thermal stresses from the assumed temperatures were calculated using ANSYS code through parametric finite element heat transfer and elastic stress analyses. While, based on the results of preliminary conceptual design and structural analyses, the ASME Code limits for the reactor structures were satisfied for the pressure boundary, the needs for inelastic analyses were indicated for evaluation of design adequacy of the support barrel and the thermal liner. To reduce thermal striping effects in the bottom are of UIS due to up-flowing sodium form reactor core, installation of Inconel-718 liner to the bottom area was proposed, and to mitigate thermal shock loads, additional stainless steel liner was also suggested. The design feasibilities of these were validated through simplified preliminary analyses. In conceptual design phase, the implementation of these results will be made for the design of the reactor structures and the reactor internal structures in conjunction with the thermal hydraulic, neutronic, and seismic analyses results. 4 tabs., 24 figs., 4 refs. (Author)

  16. Preliminary definition of improvement in juvenile arthritis.

    Science.gov (United States)

    Giannini, E H; Ruperto, N; Ravelli, A; Lovell, D J; Felson, D T; Martini, A

    1997-07-01

    To identify a core set of outcome variables for the assessment of children with juvenile arthritis (JA), to use the core set to develop a definition of improvement to determine whether individual patients demonstrate clinically important improvement, and to promote this definition as a single efficacy measure in JA clinical trials. A core set of outcome variables was established using a combination of statistical and consensus formation techniques. Variables in the core set consisted of 1) physician global assessment of disease activity; 2) parent/patient assessment of overall well-being; 3) functional ability; 4) number of joints with active arthritis; 5) number of joints with limited range of motion; and 6) erythrocyte sedimentation rate. To establish a definition of improvement using this core set, 21 pediatric rheumatologists from 14 countries met, and, using consensus formation techniques, scored each of 72 patient profiles as improved or not improved. Using the physicians' consensus as the gold standard, the chi-square, sensitivity, and specificity were calculated for each of 240 possible definitions of improvement. Definitions with sensitivity or specificity of definitions to discriminate between the effects of active agent and those of placebo, using actual trial data, was then observed. Each definition was also ranked for face validity, and the sum of the ranks was then multiplied by the kappa statistic. The definition of improvement with the highest final score was as follows: at least 30% improvement from baseline in 3 of any 6 variables in the core set, with no more than 1 of the remaining variables worsening by >30%. The second highest scoring definition was closely related to the first; the third highest was similar to the Paulus criteria used in adult rheumatoid arthritis trials, except with different variables. This indicates convergent validity of the process used. We propose a definition of improvement for JA. Use of a uniform definition will help

  17. Validation of Core Temperature Estimation Algorithm

    Science.gov (United States)

    2016-01-29

    going to heat production [6]. Second, heart rate increases to support the body’s heat dissipation. To dissipate heat, blood vessels near the skin ...vasodilate to increase blood perfusion. Thus, heart rate increases both to support the cardiac output needed both to perform work and to increase skin ...95%) were represented. The data sets also included various hydration states, clothing ensembles, and acclimatization states. Core temperature was

  18. Development and preliminary testing of a computerized Animated Activity Questionnaire (AAQ) in patients with hip and knee osteoarthritis

    DEFF Research Database (Denmark)

    Peter, Wf; Loos, M; de Vet, Hcw

    2015-01-01

    , and to preliminary assess its reliability and validity. We hypothesize that the AAQ correlates highly with performance-based tests, and moderately with self-reports. Methods Item selection was based on 1) the pilot AAQ; 2) pre-specified conditions; 3) the International Classification of Functioning core set for OA......Objective To develop an Animated Activity Questionnaire (AAQ), based on video animations, for assessing activity limitations in patients with hip/knee osteoarthritis (OA), which combines the advantages of self-reported questionnaires and performance-based tests, without many of their limitations......, 4) existing measurement instruments, and 5) focus groups of patients. Test-retest reliability was assessed in 30/110 patients. In 110 patients correlations were calculated between AAQ and self-reported Hip disability and Knee injury Osteoarthritis Outcome ADL subscale (H/KOOS). In 45/110 patients...

  19. Slow cortical potential Neurofeedback and self-management training in outpatient care for children with ADHD: study protocol and first preliminary results of a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Hanna eChristiansen

    2014-11-01

    Full Text Available Background: Treatment for children with attention deficit/hyperactivity disorder (ADHD today is predominantly pharmacological. While it is the most common treatment, it might not always be the most appropriate one. Moreover, long term effects remain unclear. Behavior therapy and non-pharmacological treatments such as neurofeedback (NF are promising alternatives, though there are no routine outpatient care/effectiveness studies yet that have included children with medication or changes in medication.Methods/design: This paper presents the protocol of a randomized controlled trial to compare the effectiveness of a Slow Cortical Potential (SCP NF protocol with self-management (SM in a high frequent outpatient care setting. Both groups (NF/SM receive a total of 30 high frequent therapy sessions. Additionally, 6 sessions are reserved for comorbid problems. The primary outcome measure is the reduction of ADHD core symptoms according to parent and teacher ratings.Preliminary Results: Untill now 58 children were included in the study (48 males, with a mean age of 8.42 (1.34 years, and a mean IQ of 110 (13.37. Conners-3 parent and teacher ratings were used to estimate core symptom change. Since the study is still ongoing, and children are in different study stages, pre-post and follow-up results are not yet available for all children included. Preliminary results suggest overall good pre-post effects, though. For parent and teacher ratings an ANOVA with repeated measures yielded overall satisfying pre-post effects (η2 .175 to .513. Differences between groups (NF vs. SM could not yet be established (p = .81.Discussion: This is the first randomized controlled trial to test the effectiveness of a NF protocol in a high frequent outpatient care setting that does not exclude children on or with changes in medication. First preliminary results show positive effects. The rationale for the trial, the design, and the strengths and limitations of the study are

  20. IEA-R1 reactor core simulation with RELAP5 code

    International Nuclear Information System (INIS)

    Rocha, Ricardo Takeshi Vieira da; Belchior Junior, Antonio; Andrade, Delvonei Alves de; Sabundjian, Gaiane; Umbehaum, Pedro Ernesto; Torres, Walmir Maximo

    2005-01-01

    This paper presents a preliminary RELAP5 model for the IEA-R1 core. The power distribution is supplied by the neutronic code, CITATION. The main objective is to model the IEA-R1 core and validate the model through the comparison of the results to the ones from COBRA and PARET, which were used in the Final Safety Analysis Report (FSAR) for this plant. Preliminary calculations regarding some simulations are presented. Boundary conditions are simulated through time dependent components. Results obtained are compared to those available for the IEA-R1. This study will be continued considering a model for the whole plant. Important transient and accidents will be analysed in order to verify the Emergency Core Cooling System - ECCS efficiency to hold its function as projected to preserve the integrity of the reactor core and guarantee its cooling. (author)

  1. Status of core nuclear design technology for future fuel

    International Nuclear Information System (INIS)

    Joo, Hyung Kook; Jung, Hyung Guk; Noh, Jae Man; Kim, Yeong Il; Kim, Taek Kyum; Gil, Choong Sup; Kim, Jung Do; Kim, Young Jin; Sohn, Dong Seong

    1997-01-01

    The effective utilization of nuclear resource is more important factor to be considered in the design of next generation PWR in addition to the epochal consideration on economics and safety. Assuming that MOX fuel can be considered as one of the future fuel corresponding to the above request, the establishment of basic technology for the MOX core design has been performed : : the specification of the technical problem through the preliminary core design and nuclear characteristic analysis of MOX, the development and verification of the neutron library for lattice code, and the acquisition of data to be used for verification of lattice and core analysis codes. The following further studies will be done in future: detailed verification of library E63LIB/A, development of the spectral history effect treatment module, extension of decay chain, development of new homogenization for the MOX fuel assembly. (author). 6 refs., 7 tabs., 2 figs

  2. Molten salt reactors: reactor cores

    International Nuclear Information System (INIS)

    1983-01-01

    In this critical analysis of the MSBR I project are examined the problems concerning the reactor core. Advantages of breeding depend essentially upon solutions to technological problems like continuous reprocessing or graphite behavior under neutron irradiation. Graphite deformation, moderator unloading, control rods and core instrumentation require more studies. Neutronics of the core, influence of core geometry and salt composition, fuel evolution, and thermohydraulics are reviewed [fr

  3. WNP-2 core model upgrade

    International Nuclear Information System (INIS)

    Golightly, C.E.; Ravindranath, T.K.; Belblidia, L.A.; O'Farrell, D.; Andersen, P.S.

    2006-01-01

    The paper describes the core model upgrade of the WNP-2 training simulator and the reasons for the upgrade. The core model as well as the interface with the rest of the simulator are briefly described . The paper also describes the procedure that will be used by WNP-2 to update the simulator core data after future core reloads. Results from the fully integrated simulator are presented. (author)

  4. On-line core monitoring with CORE MASTER / PRESTO

    International Nuclear Information System (INIS)

    Lindahl, S.O.; Borresen, S.; Ovrum, S.

    1986-01-01

    Advanced calculational tools are instrumental in improving reactor plant capacity factors and fuel utilization. The computer code package CORE MASTER is an integrated system designed to achieve this objective. The system covers all main activities in the area of in-core fuel management for boiling water reactors; design, operation support, and on-line core monitoring. CORE MASTER operates on a common data base, which defines the reactor and documents the operating history of the core and of all fuel bundles ever used

  5. Low void effect (CFV) core concept flexibility: from self-breeder to burner core - 15091

    International Nuclear Information System (INIS)

    Buiron, L.; Dujcikova, L.

    2015-01-01

    In the frame of the French strategy on sustainable nuclear energy, several scenarios consider fuel cycle transition toward a plutonium multi-recycling strategy in sodium cooled fast reactor (SFR). Basically, most of these scenarios consider the deployment of a 60 GWe SFR fleet in 2 steps to renew the French PWR fleet. As scenarios do investigate long term deployment configurations, some of them require tools for nuclear phase-out studies. Instead of designing new reactors, the adopted strategy does focus on adaptation of existing ones into burner configurations. This is what was done in the frame of the EFR project at the end of the 90's using the CAPRA approach (French acronym for Enhance Plutonium Consumption in Fast Reactor). The EFR burner configuration was obtained by inserting neutronic penalties inside the core (absorber material and/or diluent subassembly). Starting from the preliminary industrial image of a SFR 3600 MWth core based on Low Sodium Void concept (CFV in French), a 'CAPRA-like' approach has been studied. As the CFV self-breeding is ensured by fertile blankets, a first modification consisted in the substitution of the corresponding depleted uranium by 'inert' or absorber material leading to a 'natural burner' core with only small impacts on flux distribution. The next step forward CAPRA configuration was the substitution of 1/3 of the fuel pins by 'dummy' pins (MgO pellets). The small spectrum shift due to MgO material insertion leads to an increase Doppler constant which exceeds the value of the reference case. As the core sodium void worth value is conserved, the CFV CAPRA core 'safety' potential is quite similar to the one of the reference core. Fuel thermo-mechanical requirements are met by both nominal core power and fuel time residence reduction. However, these reduction factors are lower than those obtained for EFR core. The management of the enhanced reactivity swing is discussed

  6. Hollow-Core Fiber Lamp

    Science.gov (United States)

    Yi, Lin (Inventor); Tjoelker, Robert L. (Inventor); Burt, Eric A. (Inventor); Huang, Shouhua (Inventor)

    2016-01-01

    Hollow-core capillary discharge lamps on the millimeter or sub-millimeter scale are provided. The hollow-core capillary discharge lamps achieve an increased light intensity ratio between 194 millimeters (useful) and 254 millimeters (useless) light than conventional lamps. The capillary discharge lamps may include a cone to increase light output. Hollow-core photonic crystal fiber (HCPCF) may also be used.

  7. Dual-core Itanium Processor

    CERN Multimedia

    2006-01-01

    Intel’s first dual-core Itanium processor, code-named "Montecito" is a major release of Intel's Itanium 2 Processor Family, which implements the Intel Itanium architecture on a dual-core processor with two cores per die (integrated circuit). Itanium 2 is much more powerful than its predecessor. It has lower power consumption and thermal dissipation.

  8. Maximum stellar iron core mass

    Indian Academy of Sciences (India)

    60, No. 3. — journal of. March 2003 physics pp. 415–422. Maximum stellar iron core mass. F W GIACOBBE. Chicago Research Center/American Air Liquide ... iron core compression due to the weight of non-ferrous matter overlying the iron cores within large .... thermal equilibrium velocities will tend to be non-relativistic.

  9. Core TuLiP

    NARCIS (Netherlands)

    Czenko, M.R.; Etalle, Sandro

    2007-01-01

    We propose CoreTuLiP - the core of a trust management language based on Logic Programming. CoreTuLiP is based on a subset of moded logic programming, but enjoys the features of TM languages such as RT; in particular clauses are issued by different authorities and stored in a distributed manner. We

  10. Ice core carbonyl sulfide measurements from a new South Pole ice core (SPICECORE)

    Science.gov (United States)

    Aydin, M.; Nicewonger, M. R.; Saltzman, E. S.

    2017-12-01

    Carbonyl sulfide (COS) is the most abundant sulfur gas in the troposphere with a present-day mixing ratio of about 500 ppt. Direct and indirect emissions from the oceans are the predominant sources of atmospheric COS. The primary removal mechanism is uptake by terrestrial plants during photosynthesis. Because plants do not respire COS, atmospheric COS levels are linked to terrestrial gross primary productivity (GPP). Ancient air trapped in polar ice cores has been used to reconstruct COS records of the past atmosphere, which can be used to infer past GPP variability and potential changes in oceanic COS emission. We are currently analyzing samples from a newly drilled intermediate depth ice core from South Pole, Antarctica (SPICECORE). This core is advantageous for studying COS because the cold temperatures of South Pole ice lead to very slow rates of in situ loss due to hydrolysis. One hundred and eighty-four bubbly ice core samples have been analyzed to date with gas ages ranging from about 9.2 thousand (733 m depth) to 75 years (126 m depth) before present. After a 2% correction for gravitational enrichment in the firn, the mean COS mixing ratio for the data set is 312±15 ppt (±1s), with the data set median also equal to 312 ppt. The only significant long-term trend in the record is a 5-10% increase in COS during the last 2-3 thousand years of the Holocene. The SPICECORE data agree with previously published ice core COS records from other Antarctic sites during times of overlap, confirming earlier estimates of COS loss rates to in situ hydrolysis in ice cores. Antarctic ice core data place strict constraints on the COS mixing ratio and its range of variability in the southern hemisphere atmosphere during the last several millennia. Implications for the atmospheric COS budget will be discussed.

  11. Automated Core Design

    International Nuclear Information System (INIS)

    Kobayashi, Yoko; Aiyoshi, Eitaro

    2005-01-01

    Multistate searching methods are a subfield of distributed artificial intelligence that aims to provide both principles for construction of complex systems involving multiple states and mechanisms for coordination of independent agents' actions. This paper proposes a multistate searching algorithm with reinforcement learning for the automatic core design of a boiling water reactor. The characteristics of this algorithm are that the coupling structure and the coupling operation suitable for the assigned problem are assumed and an optimal solution is obtained by mutual interference in multistate transitions using multiagents. Calculations in an actual plant confirmed that the proposed algorithm increased the convergence ability of the optimization process

  12. Ice Sheets & Ice Cores

    DEFF Research Database (Denmark)

    Mikkelsen, Troels Bøgeholm

    Since the discovery of the Ice Ages it has been evident that Earth’s climate is liable to undergo dramatic changes. The previous climatic period known as the Last Glacial saw large oscillations in the extent of ice sheets covering the Northern hemisphere. Understanding these oscillations known....... The first part concerns time series analysis of ice core data obtained from the Greenland Ice Sheet. We analyze parts of the time series where DO-events occur using the so-called transfer operator and compare the results with time series from a simple model capable of switching by either undergoing...

  13. Nuclear reactor core assembly

    International Nuclear Information System (INIS)

    Baxi, C.B.

    1978-01-01

    The object of the present invention is to provide a fast reactor core assembly design for use with a fluid coolant such as liquid sodium or carbon monoxide incorporating a method of increasing the percentage of coolant flow though the blanket elements relative to the total coolant flow through the blanket and fuel elements during shutdown conditions without using moving parts. It is claimed that deterioration due to reactor radiation or temperature conditions is avoided and ready modification or replacement is possible. (U.K.)

  14. Reload core safety verification

    International Nuclear Information System (INIS)

    Svetlik, M.; Minarcin, M.

    2003-01-01

    This paper presents a brief look at the process of reload core safety evaluation and verification in Slovak Republic. It gives an overview of experimental verification of selected nuclear parameters in the course of physics testing during reactor start-up. The comparison of IAEA recommendations and testing procedures at Slovak and European nuclear power plants of similar design is included. An introduction of two level criteria for evaluation of tests represents an effort to formulate the relation between safety evaluation and measured values (Authors)

  15. A geostatistical estimation of zinc grade in bore-core samples

    International Nuclear Information System (INIS)

    Starzec, A.

    1987-01-01

    Possibilities and preliminary results of geostatistical interpretation of the XRF determination of zinc in bore-core samples are considered. For the spherical model of the variogram the estimation variance of grade in a disk-shape sample (estimated from the grade on the circumference sample) is calculated. Variograms of zinc grade in core samples are presented and examples of the grade estimation are discussed. 4 refs., 7 figs., 1 tab. (author)

  16. Hollow Core Optical Fiber Gas Lasers: Toward Novel and Practical Systems in Fused Silica

    Science.gov (United States)

    2017-05-18

    Hollow core Optically pumped Fiber Gas LASer’s (HOFGLAS’s) based on population inversion combine advantages of fiber lasers such as long interaction...polarization dependent fiber properties. Preliminary experiments were performed toward simultaneous lasing in the visible and near infrared; lasing in...words) Hollow core Optically pumped Fiber Gas LASer’s (HOFGLAS’s) based on population inversion combine advantages of fiber lasers such as long

  17. UpSet: Visualization of Intersecting Sets

    Science.gov (United States)

    Lex, Alexander; Gehlenborg, Nils; Strobelt, Hendrik; Vuillemot, Romain; Pfister, Hanspeter

    2016-01-01

    Understanding relationships between sets is an important analysis task that has received widespread attention in the visualization community. The major challenge in this context is the combinatorial explosion of the number of set intersections if the number of sets exceeds a trivial threshold. In this paper we introduce UpSet, a novel visualization technique for the quantitative analysis of sets, their intersections, and aggregates of intersections. UpSet is focused on creating task-driven aggregates, communicating the size and properties of aggregates and intersections, and a duality between the visualization of the elements in a dataset and their set membership. UpSet visualizes set intersections in a matrix layout and introduces aggregates based on groupings and queries. The matrix layout enables the effective representation of associated data, such as the number of elements in the aggregates and intersections, as well as additional summary statistics derived from subset or element attributes. Sorting according to various measures enables a task-driven analysis of relevant intersections and aggregates. The elements represented in the sets and their associated attributes are visualized in a separate view. Queries based on containment in specific intersections, aggregates or driven by attribute filters are propagated between both views. We also introduce several advanced visual encodings and interaction methods to overcome the problems of varying scales and to address scalability. UpSet is web-based and open source. We demonstrate its general utility in multiple use cases from various domains. PMID:26356912

  18. Environmental Survey preliminary report

    Energy Technology Data Exchange (ETDEWEB)

    1988-04-01

    This report presents the preliminary findings from the first phase of the Environmental Survey of the United States Department of Energy (DOE) Sandia National Laboratories conducted August 17 through September 4, 1987. The objective of the Survey is to identify environmental problems and areas of environmental risk associated with Sandia National Laboratories-Albuquerque (SNLA). The Survey covers all environmental media and all areas of environmental regulation. It is being performed in accordance with the DOE Environmental Survey Manual. This phase of the Survey involves the review of existing site environmental data, observations of the operations carried on at SNLA, and interviews with site personnel. 85 refs., 49 figs., 48 tabs.

  19. Ruiz Volcano: Preliminary report

    Science.gov (United States)

    Ruiz Volcano, Colombia (4.88°N, 75.32°W). All times are local (= GMT -5 hours).An explosive eruption on November 13, 1985, melted ice and snow in the summit area, generating lahars that flowed tens of kilometers down flank river valleys, killing more than 20,000 people. This is history's fourth largest single-eruption death toll, behind only Tambora in 1815 (92,000), Krakatau in 1883 (36,000), and Mount Pelée in May 1902 (28,000). The following briefly summarizes the very preliminary and inevitably conflicting information that had been received by press time.

  20. How cores grow by pebble accretion. I. Direct core growth

    Science.gov (United States)

    Brouwers, M. G.; Vazan, A.; Ormel, C. W.

    2018-03-01

    Context. Planet formation by pebble accretion is an alternative to planetesimal-driven core accretion. In this scenario, planets grow by the accretion of cm- to m-sized pebbles instead of km-sized planetesimals. One of the main differences with planetesimal-driven core accretion is the increased thermal ablation experienced by pebbles. This can provide early enrichment to the planet's envelope, which influences its subsequent evolution and changes the process of core growth. Aims: We aim to predict core masses and envelope compositions of planets that form by pebble accretion and compare mass deposition of pebbles to planetesimals. Specifically, we calculate the core mass where pebbles completely evaporate and are absorbed before reaching the core, which signifies the end of direct core growth. Methods: We model the early growth of a protoplanet by calculating the structure of its envelope, taking into account the fate of impacting pebbles or planetesimals. The region where high-Z material can exist in vapor form is determined by the temperature-dependent vapor pressure. We include enrichment effects by locally modifying the mean molecular weight of the envelope. Results: In the pebble case, three phases of core growth can be identified. In the first phase (Mcore mixes outwards, slowing core growth. In the third phase (Mcore > 0.5M⊕), the high-Z inner region expands outwards, absorbing an increasing fraction of the ablated material as vapor. Rainout ends before the core mass reaches 0.6 M⊕, terminating direct core growth. In the case of icy H2O pebbles, this happens before 0.1 M⊕. Conclusions: Our results indicate that pebble accretion can directly form rocky cores up to only 0.6 M⊕, and is unable to form similarly sized icy cores. Subsequent core growth can proceed indirectly when the planet cools, provided it is able to retain its high-Z material.