WorldWideScience

Sample records for preliminary conclusions based

  1. Conclusions

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Conclusions. Be it 2G or 4G, networks are vulnerable to unwanted access and thus should be protected. 4G networks would be more sensitive as its core network will be TCP/IP based. Accordingly, resource and security management schemes with seamless ...

  2. Conclusion

    DEFF Research Database (Denmark)

    Sandøy, Helge; Kristiansen, Tore

    2010-01-01

    1. Comparing empirical findings with the “mountain peak model” In the introduction to this volume, we presented a “mountain peak model” of Nordic purism based on evidence showing that language scholars and lay people are very much in agreement as to where we find the more purist languages......-speaking Finland to Finnish-speaking Finland. In this conclusion to the volume, we will summarize the empirical findings presented in the volume, findings for use and attitudes alike, and compare them with the mountain peak model. That way, we may be able to estimate the nature of the cross-national ideological...

  3. Conclusion

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Conclusion. Problems of an Under-developed Economy. Geographical Location. Terrain. Change in attitude of mainstream India required. Using Technology to overcome problems.

  4. Conclusions:

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Conclusions: Extended objects – “D-branes” – appear naturally in theories of strings. They manifest themselves as new types of physical particles in string models. They provide a powerful handle on the symmetries and dynamics of strings. Branes will play a key role ...

  5. Conclusions :

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Conclusions : No dramatic difference in the dynamics of anion-water and water-water hydrogen bonds are found for Cl- and Br- ions. Solvation shells of these ions are not rigid. For OH- in water, HB dynamics in the hydration shell determines the rate of proton transfer.

  6. Failure of Magnetic Fluid Seals Operating in Water: Preliminary Conclusions

    Directory of Open Access Journals (Sweden)

    Matuszewski Leszek

    2017-06-01

    Full Text Available The article analyses properties of magnetic fluid seals installed in rotary sealing nodes which operate in the utility water environment. Seals of this type have been examined as a possible solution to the problem with ship manoeuvring propulsion sealing. The present analysis bases on laboratory durability tests of magnetic fluid seals exposed to longterm utility water loads, at different water pressures and shaft revolutions. The basic seal durability criterion was the number of revolutions made by the sealing node shaft until the appearance of water tightness loss (leakage. It was found that the main factor leading to the wear of the seal is the relative speed of the magnetic fluid with respect to that of the utility water, and this process is heavily affected by the pressure acting on the seal. The reported test results are presented in the form of diagrams showing the seal durability (time until water tightness loss as a function of rotational speed. The curves shown in the diagrams are regular, with two different rotational speed ranges: the highspeed range, when the tightness loss is relatively fast, and the low-speed range, with a clear tendency to prolong the seal lifetime. These diagrams were given the name of durability curves of the MF seal operating in water. The results of the performed tests suggest formal similarity between the experimental data distribution concerning tightness loss processes occurring in magnetic fluid seals operating in water environment and metal fatigue processes. The article proposes a preliminary simplified durability model to describe the examined phenomenon.

  7. STELLA and SPINE data transmission experiments preliminary results and conclusions

    CERN Document Server

    Bartholome, P; Scanlan, J O

    1981-01-01

    Discusses the CERN-based proposal for a single experiment, Satellite Transmission Experiment Linking Laboratories (STELLA) and the ESA experimental programme SPINE (Space Informatics Network Experiments). Both projects are examples of experiments to explore the capability and utility of high speed data transmission by satellite, and used the European OTS. (2 refs).

  8. Conclusion of the Preliminary Safety report for the LILW Repository on Trgovska Gora

    International Nuclear Information System (INIS)

    Lokner, V.; Levanat, I.; Schaller, A.; Kucar-Dragicevic, S.; Cerskov Klika, M.; Subasic, D.

    2002-01-01

    For more than a decade, APO d.o.o. has been engaged in preparations which might lead to establishment of a radioactive waste repository on Trgovska Gora, suitable for disposal of low and intermediate level waste (LILW) from the nuclear power plant Krsko. A recent product of theses activities is the preliminary safety assessment report (PSAR) for the proposed repository. In addition to an extensive overview of the repository project status, this preliminary SAR describes how the safety assessment methodology is used to demonstrate that a LILW facility will comply with radiological protection and safety requirements after the repository closure. LILW repository is designed to isolate waste from the environment for a couple hundred years in a reasonably efficient manner. It is generally not practicable to grant full waste containment throughout that period, because it suffices to demonstrate that radionuclide release and migration will remain below acceptable levels, which is achieved through safety assessment scenarios, modeling and calculations. However, with very limited repository specific data, safety assessment can only produce a conservative estimate of the upper bounds of potential exposures the repository could inflict. This PSAR arrives at such estimates in two different ways: (a) by simple bounding calculations and (b) through more sophisticated modeling and application of dedicated computer codes, but with similar conservative assumptions. Both approaches conservatively estimate that the highest potential dose to a nearby resident cannot significantly exceed the dose constraint of 0.2 mSv per year. Only in case of inadvertent intrusion into the near-surface disposal vault, much higher doses might be inflicted immediately after the planned institutional control of 250 years expires, but that can be prevented by a longer control period. Despite the preliminary and bounding style of the calculations, the PSAR has identified most important assumptions and

  9. Water-quality monitoring at the Hoe Creek test site: review and preliminary conclusions

    Energy Technology Data Exchange (ETDEWEB)

    Wang, F T; Mead, S W; Stuermer, D H

    1982-05-20

    It has been shown that underground coal gasification (UCG) may introduce a broad range of residual gasification products into the groundwater of a coal aquifer. Sorption of many contaminants by the coal itself is an important factor in restricting the migration of these contaminants in the ground water. However, field studies, conducted at Lawrence Livermore National Laboratory's Hoe Creek site, have shown that sorption of organic compounds by coal is not as effective as expected, perhaps because the coal surface area is limited. Furthermore, if severe roof collapse has taken place during gasification, non-coal aquifers located above the gasified coal seam may be interconnected with the coal aquifer, and contaminants may enter these non-coal aquifers, in which sorption is even less effective. The Hoe Creek II and III experiments have provided opportunities to study the contamination of a sand aquifer located above a gasified coal seam in a hydrological recharge area. Preliminary results indicate that the water in the overlying sand aquifer is much less contaminated with organic compounds than the water in the gasified coal aquifer. In conducting these field investigations, valuable lessons ere learned concerning groundwater monitoring. A suggested monitoring strategy is discussed.

  10. Sweet Conclusion

    Science.gov (United States)

    Shirley, Britt M.; Wooldridge, Barbara Ross; Camp, Kerri M.

    2012-01-01

    Jen Harrington is the owner and pastry chef of Sweet Conclusion, a bakery in Tampa, Florida. Most of Harrington's business comes from baking wedding cakes, but she has been attempting to attract customers to her retail bakery, where she sells cupcakes, pies, ice cream, and coffee. Nearly four years she opened Sweet Conclusion, the retail part of…

  11. Conclusion; Zaklyuchenie

    Energy Technology Data Exchange (ETDEWEB)

    Nikitin, V I

    1961-07-01

    In this chapter of book are present conclusions about work done by author, in particular that he found comparatively simple and available ways of synthesis of glycerin of acetylene line and glycerin of ethylen line which before was unknown or almost unknown in the chemical literature.

  12. General conclusions

    International Nuclear Information System (INIS)

    Tubiana, M.

    1993-01-01

    In conclusion, a general consensus of a number of points which the author endeavours to summarize in this article: -doctors are an excellent channel for passing on information to the public -doctors feel that they do not know enough about the subject and a training on radiobiology and radiation protection is a necessity for them -communication between doctors and the general public is poor in this field -research should be encouraged in numerous areas such as: carcinogenic effect of low doses of radiation, pedagogy and risk perception

  13. Female Faculty Members in University Chemistry Departments: Observations and Conclusions Based on Site Visits

    Science.gov (United States)

    Chapman, Sally; Dixon, Felicia F.; Foster, Natalie; Kuck, Valerie J.; McCarthy, Deborah A.; Tooney, Nancy M.; Buckner, Janine P.; Nolan, Susan A.; Marzabadi, Cecilia H.

    2011-01-01

    Oral interviews in focus groups and written surveys were conducted with 877 men and women, including administrators, faculty members, postdoctoral associates, and graduate students, during one-day site visits to chemistry and chemical engineering departments at 28 Ph.D.-granting institutions. This report is a preliminary review of the perceptions…

  14. Permutation entropy based time series analysis: Equalities in the input signal can lead to false conclusions

    Energy Technology Data Exchange (ETDEWEB)

    Zunino, Luciano, E-mail: lucianoz@ciop.unlp.edu.ar [Centro de Investigaciones Ópticas (CONICET La Plata – CIC), C.C. 3, 1897 Gonnet (Argentina); Departamento de Ciencias Básicas, Facultad de Ingeniería, Universidad Nacional de La Plata (UNLP), 1900 La Plata (Argentina); Olivares, Felipe, E-mail: olivaresfe@gmail.com [Instituto de Física, Pontificia Universidad Católica de Valparaíso (PUCV), 23-40025 Valparaíso (Chile); Scholkmann, Felix, E-mail: Felix.Scholkmann@gmail.com [Research Office for Complex Physical and Biological Systems (ROCoS), Mutschellenstr. 179, 8038 Zurich (Switzerland); Biomedical Optics Research Laboratory, Department of Neonatology, University Hospital Zurich, University of Zurich, 8091 Zurich (Switzerland); Rosso, Osvaldo A., E-mail: oarosso@gmail.com [Instituto de Física, Universidade Federal de Alagoas (UFAL), BR 104 Norte km 97, 57072-970, Maceió, Alagoas (Brazil); Instituto Tecnológico de Buenos Aires (ITBA) and CONICET, C1106ACD, Av. Eduardo Madero 399, Ciudad Autónoma de Buenos Aires (Argentina); Complex Systems Group, Facultad de Ingeniería y Ciencias Aplicadas, Universidad de los Andes, Av. Mons. Álvaro del Portillo 12.455, Las Condes, Santiago (Chile)

    2017-06-15

    A symbolic encoding scheme, based on the ordinal relation between the amplitude of neighboring values of a given data sequence, should be implemented before estimating the permutation entropy. Consequently, equalities in the analyzed signal, i.e. repeated equal values, deserve special attention and treatment. In this work, we carefully study the effect that the presence of equalities has on permutation entropy estimated values when these ties are symbolized, as it is commonly done, according to their order of appearance. On the one hand, the analysis of computer-generated time series is initially developed to understand the incidence of repeated values on permutation entropy estimations in controlled scenarios. The presence of temporal correlations is erroneously concluded when true pseudorandom time series with low amplitude resolutions are considered. On the other hand, the analysis of real-world data is included to illustrate how the presence of a significant number of equal values can give rise to false conclusions regarding the underlying temporal structures in practical contexts. - Highlights: • Impact of repeated values in a signal when estimating permutation entropy is studied. • Numerical and experimental tests are included for characterizing this limitation. • Non-negligible temporal correlations can be spuriously concluded by repeated values. • Data digitized with low amplitude resolutions could be especially affected. • Analysis with shuffled realizations can help to overcome this limitation.

  15. Conclusion: From describing to prescribing--transitioning to place-based conservation [Chapter 18

    Science.gov (United States)

    William P. Stewart; Daniel R. Williams; Linda E. Kruger

    2013-01-01

    The chapters of this book describe various perspectives from the social sciences of place-based conservation. The prescriptive implications are often close to the surface and become entangled with them. This chapter highlights four overlapping approaches to the practice of place-based conservation and acknowledges the difficulty of separating descriptions from...

  16. Data-based decision making : conclusions and a data use framework

    NARCIS (Netherlands)

    Schildkamp, Kim; Lai, M.K.; Schildkamp, K.; Lai, M.K.; Earl, L.

    2013-01-01

    In this chapter, the results of all the studies presented in this book are summarized. What are the lessons learned? Based on the lessons learned, we developed a data use framework. In this framework, data use is influenced by several enablers and barriers (e.g., the school organization context,

  17. Preliminary investigations of piezoelectric based LED luminary

    DEFF Research Database (Denmark)

    Nielsen, Dennis; Andersen, Michael A. E.; Meyer, Kaspar Sinding

    2011-01-01

    , modulation schemes, LEDs and LED driving conditions are analyzed. A prototype radial mode PT optimized for ZVS (Zero Voltage Switching) is designed. FEM (Final Element Method) and measurements validates the PT design. A prototype PT based AC/DC converter operating from european mains is proposed......This paper presents a preliminary study of PT (Piezoelectric Transformer) based SMPS’s (Switch Mode Power Supplies) for LED luminary. The unique properties of PTs (efficiency, power density and EMI) make them highly suitable for this application. Power stage topologies, rectifiers circuits...

  18. Conclusive evidence for hexasomic inheritance in chrysanthemum based on analysis of a 183 k SNP array.

    Science.gov (United States)

    van Geest, Geert; Voorrips, Roeland E; Esselink, Danny; Post, Aike; Visser, Richard Gf; Arens, Paul

    2017-08-07

    Cultivated chrysanthemum is an outcrossing hexaploid (2n = 6× = 54) with a disputed mode of inheritance. In this paper, we present a single nucleotide polymorphism (SNP) selection pipeline that was used to design an Affymetrix Axiom array with 183 k SNPs from RNA sequencing data (1). With this array, we genotyped four bi-parental populations (with sizes of 405, 53, 76 and 37 offspring plants respectively), and a cultivar panel of 63 genotypes. Further, we present a method for dosage scoring in hexaploids from signal intensities of the array based on mixture models (2) and validation of selection steps in the SNP selection pipeline (3). The resulting genotypic data is used to draw conclusions on the mode of inheritance in chrysanthemum (4), and to make an inference on allelic expression bias (5). With use of the mixture model approach, we successfully called the dosage of 73,936 out of 183,130 SNPs (40.4%) that segregated in any of the bi-parental populations. To investigate the mode of inheritance, we analysed markers that segregated in the large bi-parental population (n = 405). Analysis of segregation of duplex x nulliplex SNPs resulted in evidence for genome-wide hexasomic inheritance. This evidence was substantiated by the absence of strong linkage between markers in repulsion, which indicated absence of full disomic inheritance. We present the success rate of SNP discovery out of RNA sequencing data as affected by different selection steps, among which SNP coverage over genotypes and use of different types of sequence read mapping software. Genomic dosage highly correlated with relative allele coverage from the RNA sequencing data, indicating that most alleles are expressed according to their genomic dosage. The large population, genotyped with a very large number of markers, is a unique framework for extensive genetic analyses in hexaploid chrysanthemum. As starting point, we show conclusive evidence for genome-wide hexasomic inheritance.

  19. CNRA/CSNI workshop on licensing and operating experience of computer-based I and C systems - Summary and conclusions

    International Nuclear Information System (INIS)

    2002-01-01

    researching computer-based systems important to safety to get together and to discuss their insights learned from their actual activities. The Workshop was successful in this point. It was attended by 65 people from 15 countries and by 2 international organizations. In general terms, the Workshop attempted to give answers to questions in the following areas: - What are the benefits of using computer-based I and C systems? - What national and international standards and guidance could be universally acceptable from the safety perspective? - What are the regulatory requirements for the current and future generations of digital I and C systems? - What are the major technical issues and challenges associated with applications of digital technology in I and C systems? As a general conclusion, the Workshop can be considered representative of the progress made towards reaching the targets set at the Munich workshop almost five years ago. The Munich workshop had identified areas where further development and specific improvements were needed. The Hluboka workshop has reviewed the development achieved since then. Based on the papers presented at this workshop and on the discussions by the workshop participants, it is evident that the details of the life-cycle activities and the associated acceptance criteria are still in flux and have yet to be universally acceptable. The basic trends from Munich still hold and are reaffirmed in the frame of evolving regulatory and commercial environments. Future international co-operation should strive to reach universally acceptable positions in the above areas

  20. Some strategic conclusions from an economic analysis of wind power based on simple and innovative methods and tools

    International Nuclear Information System (INIS)

    Chabot, B.

    2001-01-01

    The fast development of wind power is based on improved performance of wind turbines and on higher profitability of wind power projects. Therefore, an economic analysis is necessary to quantify past and future progress. In this respect, the paper presents a simplified economic analysis method in order to assess present and future wind energy costs and in order to determine wind tariffs able to ensure a sustainable development of this technology. Perspectives and scenarios for the development of wind power are described up to 2020 in the case of France and in the 21. century for the world. (author)

  1. General conclusions on workshop

    International Nuclear Information System (INIS)

    Rustand, H.

    2006-01-01

    The author proposes a general conclusion on the second workshop on the indemnification of damage in the event of a nuclear accident, organized in Bratislava, the 18-20 May 2005. He pointed out the most important discussions and the results revealed during these two days. (A.L.B.)

  2. Conclusions and recommendations

    International Nuclear Information System (INIS)

    1984-01-01

    The FAO/IAEA/GSF/SIDA Co-ordinated Research Programme on Cereal Grain Protein Improvement by Nuclear Techniques was a follow-up to the FAO/IAEA/GSF Co-ordinated Research Programme on the Use of Nuclear Techniques for Seed Protein Improvement. It was initiated in 1969 and ended in 1981. The objectives of the meeting were to review and evaluate the achievements of the current and previous programmes in order to draw conclusions on the possibility of genetic improvement of cereal grain protein using nuclear techniques, to identify unsolved problems and to discuss and propose possible approaches for their solution. Through reviews and discussions, conclusions and recommendations were made by the participants

  3. Preliminary study on chicken feather protein-based wood adhesives

    Science.gov (United States)

    Zehui Jiang; Daochun Qin; Chung-Yun Hse; Monlin Kuo; Zhaohui Luo; Ge Wang; Yan Yu

    2008-01-01

    The objective of this preliminary study was to partially replace phenol in the synthesis of phenol-formaldehyde resin with feather protein. Feather protein–based resins, which contained one part feather protein and two parts phenol, were formulated under the conditions of two feather protein hydrolysis methods (with and without presence of phenol during...

  4. 7. Conclusions and reflections

    OpenAIRE

    Nettle, Daniel

    2016-01-01

    But now your eyes sing the sad, sad song,Of how you lived so fast and died so young. Introduction We’ve now finished the data chapters of this book, and some conclusions are in order. In this chapter, I summarise what strike me as the main things we have learned, and suggest what their implications might be. I then devote a more extended discussion to the issue of causes of patterns of social behaviour, and how our data might bear on it. From this follows a brief consideration of what kinds o...

  5. Conclusions and recommendations

    International Nuclear Information System (INIS)

    Carrette, M.

    1997-01-01

    The paper presents conclusions and recommendations at the closing session of the NEA/OECD Workshop held at Fontenay-aux-Roses on 12-14 June 1995. The conclusions refer to issues like: public reaction to foodstuffs containing radioisotope concentrations under the danger standards, possible non-adherence of manufacturers, processors, distributors, et al, to the instructions and guidance from radiation protection specialists, integration of all the food chain factors in the elaboration of the emergency intervention programs, etc. Among the most significant recommendations the following may be mentioned: 1. Differences between different intervention levels and the maximum admissible levels agreed upon by national, regional or international nutrition authorities should be further studied; 2. Problems created by the Chernobyl accident (as for instance, the methods of treatment of food chain products containing unacceptable radioactivity concentrations) are still present and must be solved; 3. Further studies should be done on the socio-cultural aspects of the communication, particularly on the information in rural environment; 4. The preventive measures in agriculture should be implemented as rapidly as possible; 5. In elaborating programmes of agriculture countermeasures, the management of contaminated media, particularly, of forests and their effect on agriculture

  6. Tawhidic Based Economic System: A Preliminary Conception

    Directory of Open Access Journals (Sweden)

    Nurul Hilmiyah Hilmiyah

    2016-12-01

    Full Text Available This study investigates contemporary mainstream economic system, does Islamic Economics taking advantage of the shortfall of the system outlined above based on Tawhidical approach? By using descriptive qualitative method this paper proposed the appropriate of Islamic economics theorize that the Islamic system provide the ideal form of a socio-economic order. This paper found that Tawhidic based economics approaches can be focused towards seeing wholes of economics, rather than parts; seeing economics activities as a worship, rather than competition; cultivating the solidarity (charity, rather than individualism and creating the justice, rather than injustice. Thus this paper designed to provide the concept of Islamic economic system with Tawhid as the basis, to fit the philosophy of economic science and reality of human life. The paper also shows the position of Tawhid in the system and theory of economy in creating prosperity and benefit for all mankind comparing to mainstream economic system and their theory.DOI: 10.15408/aiq.v9i1.3481 

  7. Summary and Conclusions

    International Nuclear Information System (INIS)

    2013-01-01

    This section summarizes the presentations and Panel discussions of the 4 technical sessions of the workshop: 1 - Regulatory cooperation on generic and design specific issues, MDEP working groups (EPR, AP1000), vendor inspection co-operation, digital I and C, and codes and standards (7 presentations); 2 - Regulatory positions on siting practices and enhancements as a result of lessons learned from Fukushima accident (5 presentations); 3 - Construction experience and regulatory oversight of new reactor construction activities (6 presentations); 4 - Lessons learned from regulatory licensing reviews of new reactor designs (6 presentations). The main workshop conclusions are listed as follows: - Harmonization is a long term goal and significant progress has been made. However, this long term objective needs to be associated with short term measurable steps; - MDEP approach to tackle on one side with specific technical subjects, and to strive harmonisation on generic topics was considered appropriate; - Convergence on technical requirements is more realistic than harmonization of codes and standard; - Beneficial early engagement of different stakeholders specially at the siting stage has been acknowledged; - Need to characterise the hazards and to keep updated the safety assessment (PSR); - Land use issues are important particularly after Fukushima; - Commissioning aspects (e.g. training aspects for inspectors) should be addressed by WGRNR taking into account MDEP interaction; - Importance of WGRNR ConEx Programme: construction experience sharing is a leverage for quality and so for a future safe operation of NPPs; - Capability of licensee to follow the responsibility of design changes (could be an issue for small utilities); - Importance of Periodic Safety Reviews to review and account for the design. Finally, the WGRNR has convened that a third conference should be held in about two years time (2014- 2015)

  8. Market based consumer adaptation. Preliminary study

    International Nuclear Information System (INIS)

    Saele, Hanne

    2005-04-01

    This report is a foundation for further research in the project ''Market based consumer adaptation'', project period 2005-2008. The report describes characteristics of shortage periods for both energy and effects, low priority consumption, power products and network tariffs that may contribute to increased flexibility in consumption and limitations in the IT-systems of today and discusses what problems would be of interest for further studies. The reduction of low priority consumption and the activation of price elasticity would be challenges both for effect and energy shortages. Private consumption would however, partly be different due to the time perspective. It is expected that periods of effect shortages would be of only a few hours and the challenge would be to obtain sufficient response at an hourly basis at load disconnection. The energy shortage is expected to last longer which results in problems in obtaining sufficient and real consumer reduction over time in order to reduce the danger of critical shortage. Important elements in order to supply new power products and network tariffs which contributes to increased flexibility in the consumption, are technology for current registration and remote control of consumption, contracts between the involved parties and the framework conditions that gives incentives for establishing new network/power products. When several parties shall use the same measurements for accounting it would be necessary for all the figures to arrive in time and that corrections are avoided as much as possible. It would also be challenging for the parties whether new products satisfy the regulations. Pricing in network tariffs is subject to more legal public regulations than developing a power product. This may make it difficult to produce ''correct'' network tariffs due to regulation and at the same time interest more customers to making deals with such tariffs. Even if the power suppliers to a certain extent, are more free to develop

  9. Evidence-Based Conclusions Concerning Practice, Curriculum Design and Curriculum Reform in a Civil Engineering Capstone Design Course in Hong Kong

    Science.gov (United States)

    Chan, Cecilia K. Y.; Wong, George C. K.; Law, Ada K. H.; Zhang, T.; Au, Francis T. K.

    2017-01-01

    This study aimed to provide evidence-based conclusions from students concerning a capstone-design course in a civil engineering programme in Hong Kong. The evidence was generated by designing a student-experience questionnaire. The questionnaire instrument was assessed for internal consistency in four scales (curriculum and structure changes;…

  10. Summary and conclusions

    International Nuclear Information System (INIS)

    2011-01-01

    authorities, reactor designers, and operators/ licensees perspectives on the various practices used in the regulation of nuclear power plant siting (selection, evaluation and site preparation). This session was also aimed to address issues on sites where a mixture of activities are taking place (e.g., operating units, new construction, decommissioning, etc.) including organisation of the regulators and licensee/engineering organisation, methods, systems, etc. Conclusions: In general workshop participants agreed on the need to regularly have these kind of forums to discuss relevant regulatory issues for new builds. One important aspect of this workshop was the participation of 'New Entrants'. The interaction between NEA member countries with mature nuclear power plants and newcomers was quite important since it gave newcomers the possibility to benefit of mature international practices in order to focus their regulatory oversight and control. NEA members could also benefit from insights the New Entrants discover as they develop or enhance their regulatory controls. In addition technical exchanges associated with construction experience of New Entrants as they begin to license, build and operate NPP could benefit NEA members

  11. Conclusion. Chapter 4

    International Nuclear Information System (INIS)

    1999-01-01

    Beginning 1992, January 1 Semipalatinsk test site was transforming into large research scientific center. The National Nuclear Center (NNC) was formed on the base of site's research enterprises. The principal problems of NNC are as follows: liquidation of nuclear tests consequences; liquidation of technological infrastructure for preparation and conducting of nuclear tests, creation of technology for radioactive wastes store; implementation of atomic energy development conception in Kazakhstan, etc. Program of site conversion constantly is expanding. In this chapter measures by rehabilitation of injured population are revealed. Taking into account radioecological situation, dose loadings, demographic indexes, sick rate and mortality of population on territories exposed to site's influence Government of Kazakhstan adopted Decree on declaration of these lands of zone of ecological catastrophe. Measures on improvement of radioecological situation are reduce to following ones: determination of irradiation doses received by population during testing period; study of existing radiation contamination; study of all possible sources for dose increasing and taking into account other ones; information of population about radioecological situation and about all consequences of nuclear tests. In 1992 Supreme Soviet of Republic of Kazakhstan worked out and adopted law On social defence of citizens suffered from consequences of nuclear tests on Semipalatinsk test site. It was distinguished four zones of radiation risk. The first zone is zone of extreme risk. It is part of territory subjected to radiation contamination with dose of influence on population above 100 rem during of total period of tests conducting. To this zone belong following inhabited settlements: Budene, Dolon', Cheremushki, Mostik, Sarzhal, Isa, Sarpan, Karakoryk, Zagotskot-2. Second zone is zone of maximal radiation risk. To this zone belong inhabited settlements of following districts: Abaj, Abraly, Beskargaj

  12. [Efficiency of computer-based documentation in long-term care--preliminary project].

    Science.gov (United States)

    Lüngen, Markus; Gerber, Andreas; Rupprecht, Christoph; Lauterbach, Karl W

    2008-06-01

    In Germany the documentation of processes in long-term care is mainly paper-based. Planning, realization and evaluation are not supported in an optimal way. In a preliminary study we evaluated the consequences of the introduction of a computer-based documentation system using handheld devices. We interviewed 16 persons before and after introducing the computer-based documentation and assessed costs for the documentation process and administration. The results show that reducing costs is likely. The job satisfaction of the personnel increased, more time could be spent for caring for the residents. We suggest further research to reach conclusive results.

  13. Conclusions

    Indian Academy of Sciences (India)

    In long-term better adapted varieties are needed to adapt to multiple stresses linked with climate change. ... and water management are available which can help minimize negative impacts. ... Adaptation practices take time to become effective.

  14. Conclusion

    NARCIS (Netherlands)

    Grignon, F.; Mazrui, A.; Rutten, M.M.E.M.; Rutten, M.M.E.M.; Mazrui, A.; Grignon, F.

    2001-01-01

    The outcome of a three-day conference held at the African Studies Centre, Leiden, The Netherlands, in September 1998, this book on the 1997 Kenya general elections is organized in four parts: the direct pre-electoral background; technical and national analysis of the general elections, including the

  15. Conclusion

    OpenAIRE

    Rainhorn, Jean-Daniel; Boudamoussi, Samira El

    2017-01-01

    “Science without conscience is but the ruin of the soul.”—François Rabelais, 1542 A special feature of this book is to bring together the work of researchers coming from different disciplines and having various themes of reflection or practices in the field of biomedicine. While the general trend of science goes towards increasing specialization, the project of this book is to look at the use of medical advances in a transversal perspective. In other words, it intends to highlight what unregu...

  16. Conclusions

    International Nuclear Information System (INIS)

    Mandil, C.

    1994-01-01

    The renewable energies and the nuclear one are complementary. They belong to the french energy policy, which has three aims: strategic, economic and environmental. They contribute to the diversification of the energy balance and to the energy competitiveness. Energy savings might be achieved and renewable energies might be developed for the future

  17. Conclusions

    Indian Academy of Sciences (India)

    Confounding effect of obesity and associated co-morbidities (especially on metabolic abnormalities, cardiovascular and cerebrovascular morbidity) should be clearly dissected out in future studies ...

  18. Conclusion

    OpenAIRE

    Houmed Soulé, Aramis

    2018-01-01

    Au cours de son règne qui a duré plus d’une quarantaine d’années, en une période cruciale de l’histoire de la Corne de l’Afrique, Maḥammad Ḥanfaré parvient à préserver son sultanat, à défaut de l’ensemble du pays ‘Afar, des visées impérialistes d’où qu’elles viennent. Malheureusement, l’indépendance de cette entité politique ‘Afar ne lui survit pas, du moins sur le plan international. Des luttes fratricides pour sa succession qui opposent ses nombreux héritiers et dont les prémices apparaisse...

  19. Conclusion

    DEFF Research Database (Denmark)

    Fahnøe, Kristian Relsted; Warming, Hanne

    2017-01-01

    analysis approach reveal how clients’ struggles in intimate and societal life, and in public and private spaces, are intertwined with geo-politics and global flows of governance strategies, e.g. neoliberalism and managerialism, which also condition social work practices. Indeed, social work constitutes......Fahnøe and Warming provide a cogent overview of how a lived citizenship approach enables critical analyses of social work and social policies by addressing challenges related to rights, recognition, participation, belonging and identity. The sub-concept of intimate citizenship and a spatial...... a kind of sociological magnifying glass through which broader social changes can be studied, including dynamics of inclusion and exclusion, new conflicts and modes of resistance, and new social pathologies....

  20. Conclusion

    DEFF Research Database (Denmark)

    Warming, Hanne; Fahnøe, Kristian

    2017-01-01

    analysis approach reveal how clients’ struggles in intimate and societal life, and in public and private spaces, are intertwined with geo-politics and global flows of governance strategies, e.g. neoliberalism and managerialism, which also condition social work practices. Indeed, social work constitutes......Warming and Fahnøe provide a cogent overview of how a lived citizenship approach enables critical analyses of social work and social policies by addressing challenges related to rights, recognition, participation, belonging and identity. The sub-concept of intimate citizenship and a spatial...... a kind of sociological magnifying glass through which broader social changes can be studied, including dynamics of inclusion and exclusion, new conflicts and modes of resistance, and new social pathologies....

  1. Conclusion

    DEFF Research Database (Denmark)

    de Vreese, Claes; Reinemann, Carsten; Esser, Frank

    2017-01-01

    At the outset, we asked if there is any good news about the news and, if so, where the good news is. In academic research and public discussions about news and democracy, one fi nds different interpretations of the state of current news provision. A tendency towards pessimism about current news...... is seen as having a negative impact on the quality of political life and democracy. Set against the pessimism and caution in the public debate and literature on news quality and the performance of political journalism, we were not optimistic that we would fi nd good-quality news or that we would be able...... to offer some good news as a positive antidote, so to speak, to the pervasive pessimism in the literature....

  2. Conclusions

    International Nuclear Information System (INIS)

    Brookes, L.G.; Motamen, H.

    1984-01-01

    The paper covers the following: economics of nuclear power; nuclear or fossil-fuel plants; power systems; methods of capital investment appraisal; size factor; nuclear industry; uranium demand; fuel cycle; fast reactors; choice of reactors; case studies from France; power plants in USA and West Germany; electricity tariffs; nuclear energy in Middle Eastern states; energy growth and economic growth; nuclear energy as macroeconomic influence; future energy options. (U.K.)

  3. Conclusion

    DEFF Research Database (Denmark)

    Jørgensen, Christian Helms; Wallo, Andreas; Toiviainen, Hanna

    2015-01-01

    Work in times of globalisation and uncertainty is undergoing considerable changes, which has strengthened the importance of work as a site of learning. New trends in production, such as digitalisation, challenge traditional modes of producing goods and services. Emerging forms of flexible...... production and knowledge-work offer growing learning opportunities to people throughout their active working life. In contrast to the stable and standardised modes of Fordist production, modern working life is characterised by rapid changes and employees interacting across globally distributed professional...... explores the challenges of working and learning on the boundaries between education and working life. Globalisation affects the transition patterns from vocational education to the labour market in many ways (Schoon & Silbereisen, 2009), even though the specific challenges to national-level policies vary...

  4. Conclusions

    Science.gov (United States)

    Ahonen, Pasi; Alahuhta, Petteri; Daskala, Barbara; Delaitre, Sabine; Hert, Paul De; Lindner, Ralf; Maghiros, Ioannis; Moscibroda, Anna; Schreurs, Wim; Verlinden, Michiel

    Some say that an increase in security does not necessarily mean a further encroachment on privacy - indeed, security is necessary to protect personal data and our privacy. Networks must be secure, our personal devices, reliable, dependable and trustworthy. But security is a multifaceted term, with many dimensions. We are of the view that an increase in security most likely will encroach upon our privacy in an ambient intelligence world. Surveillance cameras will continue to proliferate. We assume that, whatever the law is, whatever privacy protections government and business say they honour, our telecommunications, e-mails and Internet usage will be monitored to an increasing degree. The same will be true of our interfaces with the world of ambient intelligence.

  5. Conclusion

    International Nuclear Information System (INIS)

    Ainul Hayati Daud; Hazmimi Kasim

    2010-01-01

    In Asia, Japan and the Republic of Korea have conducted similar studies but relying on statistical data and used inputs and outputs (I-O) methodology, utilizing on general macro-level data. In contrast, this study captures data directly through surveys using questionnaires, face-to-face interviews, case studies and focus group discussions. The impact of nuclear technology applications in Malaysia were evaluated both quantitatively and qualitatively. These impacts are then linked to a broader objective associated with technological development, namely wealth generation, knowledge generation and societal well-being. In the process of the study, users and practitioners of the technology highlighted issues and challenges faced by them. To cap the study, the level of activities of nuclear technology in Malaysia was benchmarked against those in Japan and the Republic of Korea. This chapter highlights the results of the study, the outcome of the study, followed by recommendations as response to issues and challenges raised by respondents, and finally the way forward for monitoring and charting further progress of nuclear technology in the country. (author)

  6. Conclusions

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. First study on fHSC. First study on fHSC. fHSC exhibit embryonic stem cell like properties. fHSC therapy results in myocardial regeneration in rat model of MI. fHSC may be a novel stem cell type for cardiovascular regeneration.

  7. Conclusion

    International Nuclear Information System (INIS)

    2000-01-01

    In the monograph peculiarities of radioinduced sexual dysfunctions of Chernobyl accident liquidators are described. It is shown, that ones of principal clinical manifestations of stochastic radio-genetic effects are sexual dysfunctions. Assessment in point of view of stages and components of copulative cycle is carried out. Authors made attempt to take in account all involved in sexual dysfunctions systems for examined contingent. It is noted, that genesis of radioinduced sexual dysfunctions is complex and it includes both the influence of vegetative nervous system damage and the direct damage of gonads. During clinical examination with patients it is revealed that both vegetative-vascular dysfunctions and asteno-neurotic dysfunctions are dominating. Authors noting that mentioned sexual dysfunctions are caused by low dose irradiation, and they have certain distinctions. Measures for comprehensive rehabilitation of suffered contingent in late period after irradiation are developed

  8. Conclusions

    Indian Academy of Sciences (India)

    Microbial organisms play a major role in assimilation of P from the water column and also from the interstitial waters. Mineralisation of microbial bodies is a very rapid process and autophosphatization may occur within few hours or days after death. Geo-microbiology is an important subject and needs to be developed.

  9. Conclusion

    International Nuclear Information System (INIS)

    Timofeev, Yu.M.; Zikiryakhodjaev, D.Z.

    1997-01-01

    In this chapter of book authors made following summary: the cancerous growths of anal canal is rare form of growths; extension of anal canal depends from sex, age, weight and growth of patient; the developed schemes of classification and staging of cancerous growths of anal canal have important role for growths systematization; typical symptoms are blood in excrement, pains in anus, presence of swelling in anus, the treatment of the cancerous growths of anal canal must be varied

  10. The preliminary Long Duration Exposure Facility (LDEF) materials data base

    International Nuclear Information System (INIS)

    Funk, J.G.; Strickland, J.W.; Davis, J.M.

    1992-10-01

    A preliminary Long Duration Exposure Facility (LDEF) Materials Data Base was developed by the LDEF Materials Special Investigation Group (MSIG). The LDEF Materials Data Base is envisioned to eventually contain the wide variety and vast quantity of materials data generated for LDEF. The data is searchable by optical, thermal, and mechanical properties, exposure parameters (such as atomic oxygen flux), and author(s) or principal investigator(s). The LDEF Materials Data Base was incorporated into the Materials and Processes Technical Information System (MAPTIS). MAPTIS is a collection of materials data which was computerized and is available to engineers, designers, and researchers in the aerospace community involved in the design and development of spacecraft and related hardware. This paper describes the LDEF Materials Data Base and includes step-by-step example searches using the data base. Information on how to become an authorized user of the system is included

  11. The preliminary Long Duration Exposure Facility (LDEF) materials data base

    Science.gov (United States)

    Funk, Joan G.; Strickland, John W.; Davis, John M.

    1992-01-01

    A preliminary Long Duration Exposure Facility (LDEF) Materials Data Base was developed by the LDEF Materials Special Investigation Group (MSIG). The LDEF Materials Data Base is envisioned to eventually contain the wide variety and vast quantity of materials data generated for LDEF. The data is searchable by optical, thermal, and mechanical properties, exposure parameters (such as atomic oxygen flux), and author(s) or principal investigator(s). The LDEF Materials Data Base was incorporated into the Materials and Processes Technical Information System (MAPTIS). MAPTIS is a collection of materials data which was computerized and is available to engineers, designers, and researchers in the aerospace community involved in the design and development of spacecraft and related hardware. This paper describes the LDEF Materials Data Base and includes step-by-step example searches using the data base. Information on how to become an authorized user of the system is included.

  12. Preliminaries

    Directory of Open Access Journals (Sweden)

    Desde el jardín de Freud

    2014-10-01

    Full Text Available Desde el Jardín de Freud se encuentra indexada en el IBN-Publindex (Colciencias, en categoría C, y en Latindex. También se encuentra en las siguientes bases de datos y catálogos: ebsco, Dialnet, Rebiun, Doaj y e-Revistas.

  13. CONCLUSIONS Urban Children and Adolescents

    Indian Academy of Sciences (India)

    CONCLUSIONS Urban Children and Adolescents. Increasing prevalence of overweight and obesity and measures of regional (central) adiposity. High prevalence of markers of dysmetabolic state in urban adolescents. ~10% prevalence of dysglycemia in overweight / obese school children.

  14. Chapter 6: Conclusions and recommendations

    International Nuclear Information System (INIS)

    1995-01-01

    This chapter provides a brief summary of conclusions with respect to project implementation issues. Furthermore, the chapter contains recommendations on future applications of the modelling system and on water resources management in the project area

  15. Summary and conclusions [Chapter 11

    Science.gov (United States)

    Daniel G. Neary; John N. Rinne; Alvin L.. Medina

    2012-01-01

    Summaries and conclusions of each chapter are compiled here to provide a “Quick Reference” guide of major results and recommendations for the UVR. More detail can be obtained from individual chapters.

  16. CONCLUSIONS New Delhi Birth Cohort

    Indian Academy of Sciences (India)

    CONCLUSIONS New Delhi Birth Cohort. Crossing BMI centiles and early adiposity rebound associated with adult metabolic syndrome. BMI gain in infancy and early childhood – associated more with adult lean mass. BMI gain in later childhood / adolescence – associated more with adult fat mass and constituents of ...

  17. A preliminary report of music-based training for adult cochlear implant users: rationales and development

    Science.gov (United States)

    Gfeller, Kate; Guthe, Emily; Driscoll, Virginia; Brown, Carolyn J.

    2015-01-01

    Objective This paper provides a preliminary report of a music-based training program for adult cochlear implant (CI) recipients. Included in this report are descriptions of the rationale for music-based training, factors influencing program development, and the resulting program components. Methods Prior studies describing experience-based plasticity in response to music training, auditory training for persons with hearing impairment, and music training for cochlear implant recipients were reviewed. These sources revealed rationales for using music to enhance speech, factors associated with successful auditory training, relevant aspects of electric hearing and music perception, and extant evidence regarding limitations and advantages associated with parameters for music training with CI users. This information formed the development of a computer-based music training program designed specifically for adult CI users. Results Principles and parameters for perceptual training of music, such as stimulus choice, rehabilitation approach, and motivational concerns were developed in relation to the unique auditory characteristics of adults with electric hearing. An outline of the resulting program components and the outcome measures for evaluating program effectiveness are presented. Conclusions Music training can enhance the perceptual accuracy of music, but is also hypothesized to enhance several features of speech with similar processing requirements as music (e.g., pitch and timbre). However, additional evaluation of specific training parameters and the impact of music-based training on speech perception of CI users are required. PMID:26561884

  18. Base-line investigations of birds in relation to an offshore wind farm at Horns Rev: results and conclusions 2000/2001

    Energy Technology Data Exchange (ETDEWEB)

    Kjaer Christensen, T.; Clausager, I.; Krag Petersen, I. [NERI, Dept. of Coastal Zone Ecology, Roskilde (Denmark)

    2001-07-01

    This report presents the combined results of two years of base-line investigations of birds performed during August 1999 - April 2001 in relation to the proposed construction of an offshore wind farm at Horns Rev in the Danish part of the North Sea ca 14 km southwest of Blaevandshuk. Based on the distribution of the most abundant bird species recorded during 13 aerial surveys, there were no indications that the wind farm area was of any particular importance to the birds' exploitation of the Horns Rev area. Fish-eating species like divers, gannet, terns, auks and gulls generally showed scattered and variable distributions, occurring in the areas north and south of Horns Rev, and with low numbers occurring on the reef proper and within the planned wind farm area. The distribution of benthic foraging species, eider and common scoter, showed that they mainly exploited the coastal parts of the area off Blaevandshuk and Skallingen, although the common scoter was found in relatively high numbers on the southeast slopes of Horns Rev and within the wind farm area in the April 2001 survey. Preference analyses of bird exploitation of the Horns Rev area showed that if the birds completely avoid the wind farm area after erection of the wind turbines, this will affects less than 1% of the different species, except divers of which 1.65% will be affected. If the birds avoid the wind farm area and an adjacent 4 km zone (worst case scenario), it is estimated to affect 11% of the common scoter, 10% of the gannet, 7-9% of the divers, alcids and velvet scoter and 0-6% of the remaining species. The seasonal occurrence of the recorded species was fully comparable to the seasonal occurrence of these species recorded at Blaevandshuk since 1963. Year-to-year variation in abundance between the seasons August 1999 - April 2000 and August 2000 - April 2001 was mainly found in species that migrate through the Horns Rev area (terns, gannet, kittiwake), and with less pronounced variation in

  19. Base-line investigations of birds in relation to an offshore wind farm at Horns Rev: results and conclusions 2000/2001

    International Nuclear Information System (INIS)

    Kjaer Christensen, T.; Clausager, I.; Krag Petersen, I.

    2001-01-01

    This report presents the combined results of two years of base-line investigations of birds performed during August 1999 - April 2001 in relation to the proposed construction of an offshore wind farm at Horns Rev in the Danish part of the North Sea ca 14 km southwest of Blaevandshuk. Based on the distribution of the most abundant bird species recorded during 13 aerial surveys, there were no indications that the wind farm area was of any particular importance to the birds' exploitation of the Horns Rev area. Fish-eating species like divers, gannet, terns, auks and gulls generally showed scattered and variable distributions, occurring in the areas north and south of Horns Rev, and with low numbers occurring on the reef proper and within the planned wind farm area. The distribution of benthic foraging species, eider and common scoter, showed that they mainly exploited the coastal parts of the area off Blaevandshuk and Skallingen, although the common scoter was found in relatively high numbers on the southeast slopes of Horns Rev and within the wind farm area in the April 2001 survey. Preference analyses of bird exploitation of the Horns Rev area showed that if the birds completely avoid the wind farm area after erection of the wind turbines, this will affects less than 1% of the different species, except divers of which 1.65% will be affected. If the birds avoid the wind farm area and an adjacent 4 km zone (worst case scenario), it is estimated to affect 11% of the common scoter, 10% of the gannet, 7-9% of the divers, alcids and velvet scoter and 0-6% of the remaining species. The seasonal occurrence of the recorded species was fully comparable to the seasonal occurrence of these species recorded at Blaevandshuk since 1963. Year-to-year variation in abundance between the seasons August 1999 - April 2000 and August 2000 - April 2001 was mainly found in species that migrate through the Horns Rev area (terns, gannet, kittiwake), and with less pronounced variation in

  20. Conclusions and recommendations based on interim report

    International Nuclear Information System (INIS)

    Benson, B.

    1991-01-01

    This memorandum discusses five key issues that initial interviews have brought into focus: The preoccupation of the public with nuclear waste disposal, the credibility of public opinion polls addressing nuclear power, the unlikelihood of dramatic change in opinion by nuclear critics, difficulties in communicating technical concepts, and the problem of focussing narrowly or broadly on policy issues

  1. Conclusion from the fifth topic

    International Nuclear Information System (INIS)

    Gin, St.; Advocat, Th.

    1997-01-01

    The topic ''mechanics and alteration kinetics of glasses'' is a crucial point for the understanding of the long-term behaviour of nuclear glasses. Kinetic models used in simulation are based on the works made by Grambow who imputes the control of the alteration kinetics of borosilicate glasses to the desorption of the ortho-silica acid produced at the reactive interface. The ensuing kinetics law requires the existence of an equilibrium of the silica at the interface glass/gel and the existence of a linear concentration gradient dissolved in the interstitial gel solution. The role of the gel needs further studies to be well understood. The difficulty lies in the fact that the composition and the structure of the gel varies with time, space (anisotropy) and with the conditions of alteration (temperature, pH, flowrate...). (A.C.)

  2. Using Web-Based Homework to Teach Principles of Microeconomics: A Preliminary Investigation

    Science.gov (United States)

    Mitchell, Jeannette C.; Mitchell, Johanna E.

    2017-01-01

    This study evaluates an interactive web-based homework designed to increase student understanding in a principles of microeconomics course. Employing concepts from Action Research, the preliminary investigation was undertaken based on assumptions about the efficacy of online educational resources. Do students who do well on online homework improve…

  3. A preliminary analysis of the reactor-based plutonium disposition alternative deployment schedules

    International Nuclear Information System (INIS)

    Zurn, R.M.

    1997-09-01

    This paper discusses the preliminary analysis of the implementation schedules of the reactor-based plutonium disposition alternatives. These schedule analyses are a part of a larger process to examine the nine decision criteria used to determine the most appropriate method of disposing of U.S. surplus weapons plutonium. The preliminary analysis indicates that the mission durations for the reactor-based alternatives range from eleven years to eighteen years and the initial mission fuel assemblies containing surplus weapons-usable plutonium could be loaded into the reactors between nine and fourteen years after the Record of Decision

  4. Preliminary design of GDT-based 14 MeV neutron source

    International Nuclear Information System (INIS)

    Du Hongfei; Chen Dehong; Wang Hui; Wang Fuqiong; Jiang Jieqiong; Wu Yican; Chen Yiping

    2012-01-01

    To meet the need of D-T fusion neutron source for fusion material testing, design goals were presented in this paper according to the international requirements of neutron source for fusion material testing. A preliminary design scheme of GDT-based 14 MeV neutron source was proposed, and a physics model of the neutron source was built based on progress of GDT experiments. Two preliminary design schemes (i. e. FDS-GDT1, FDS-GDT2) were designed; among which FDS-GDT2 can be used for fusion material testing with neutron first wall loading of 2 MW/m 2 . (authors)

  5. The development and preliminary validation of a Preference-Based Stroke Index (PBSI

    Directory of Open Access Journals (Sweden)

    Clarke Ann E

    2003-09-01

    Full Text Available Abstract Background Health-related quality of life (HRQL is a key issue in disabling conditions like stroke. Unfortunately, HRQL is often difficult to quantify in a comprehensive measure that can be used in cost analyses. Preference-based HRQL measures meet this challenge. To date, there are no existing preference-based HRQL measure for stroke that could be used as an outcome in clinical and economic studies of stroke. The aim of this study was to develop the first stroke-specific health index, the Preference-based Stroke Index (PBSI. Methods The PBSI includes 10 items; walking, climbing stairs, physical activities/sports, recreational activities, work, driving, speech, memory, coping and self-esteem. Each item has a 3-point response scale. Items known to be impacted by a stroke were selected. Scaling properties and preference-weights obtained from individuals with stroke and their caregivers were used to develop a cumulative score. Results Compared to the EQ-5D, the PBSI showed no ceiling effect in a high-functioning stroke population. Moderately high correlations were found between the physical function (r = 0.78, vitality (r = 0.67, social functioning (r = 0.64 scales of the SF-36 and the PBSI. The lowest correlation was with the role emotional scale of the SF-36 (r = 0.32. Our results indicated that the PBSI can differentiate patients by severity of stroke (p Conclusions Content validity and preliminary evidence of construct validity has been demonstrated. Further work is needed to develop a multiattribute utility function to gather information on psychometric properties of the PBSI.

  6. Diabetes mellitus: preliminary health-promotion activity based on ...

    African Journals Online (AJOL)

    Objectives: To investigate the effects of a service-learning-based health promotion elective in influencing knowledge of diabetes mellitus (DM) and ways to prevent it. Method: A computer-based quiz, an information poster, interactive models and a take-home information leaflet on DM were developed as part of an exhibit ...

  7. Preliminary results of a battery-based, multi megawatt 200 kA pulsed power supply.

    NARCIS (Netherlands)

    Karthaus, W.; Kolkert, W.J.; Nowee, J.

    1989-01-01

    A pulsed power supply consisting of a fast discharge battery, a switch based on silicon-controlled-rectifier SCR technology, and an energy storage/pulse transformer is discussed. Preliminary results indicate that the battery is capable of discharging current pulses with reproducible peak values of

  8. Experience base for Radioactive Waste Thermal Processing Systems: A preliminary survey

    International Nuclear Information System (INIS)

    Mayberry, J.; Geimer, R.; Gillins, R.; Steverson, E.M.; Dalton, D.; Anderson, G.L.

    1992-04-01

    In the process of considering thermal technologies for potential treatment of the Idaho National Engineering Laboratory mixed transuranic contaminated wastes, a preliminary survey of the experience base available from Radioactive Waste Thermal Processing Systems is reported. A list of known commercial radioactive waste facilities in the United States and some international thermal treatment facilities are provided. Survey focus is upon the US Department of Energy thermal treatment facilities. A brief facility description and a preliminary summary of facility status, and problems experienced is provided for a selected subset of the DOE facilities

  9. A MYSQL-BASED DATA ARCHIVER: PRELIMINARY RESULTS

    International Nuclear Information System (INIS)

    Matthew Bickley; Christopher Slominski

    2008-01-01

    Following an evaluation of the archival requirements of the Jefferson Laboratory accelerator's user community, a prototyping effort was executed to determine if an archiver based on MySQL had sufficient functionality to meet those requirements. This approach was chosen because an archiver based on a relational database enables the development effort to focus on data acquisition and management, letting the database take care of storage, indexing and data consistency. It was clear from the prototype effort that there were no performance impediments to successful implementation of a final system. With our performance concerns addressed, the lab undertook the design and development of an operational system. The system is in its operational testing phase now. This paper discusses the archiver system requirements, some of the design choices and their rationale, and presents the acquisition, storage and retrieval performance

  10. Computer-based attention training in the schools for children with attention deficit/hyperactivity disorder: a preliminary trial.

    Science.gov (United States)

    Steiner, Naomi J; Sheldrick, Radley Christopher; Gotthelf, David; Perrin, Ellen C

    2011-07-01

    Objective. This study examined the efficacy of 2 computer-based training systems to teach children with attention deficit/hyperactivity disorder (ADHD) to attend more effectively. Design/methods. A total of 41 children with ADHD from 2 middle schools were randomly assigned to receive 2 sessions a week at school of either neurofeedback (NF) or attention training through a standard computer format (SCF), either immediately or after a 6-month wait (waitlist control group). Parents, children, and teachers completed questionnaires pre- and postintervention. Results. Primary parents in the NF condition reported significant (P ADHD index, the BASC Attention Problems Scale, and on the Behavioral Rating Inventory of Executive Functioning (BRIEF). Conclusion. This randomized control trial provides preliminary evidence of the effectiveness of computer-based interventions for ADHD and supports the feasibility of offering them in a school setting.

  11. 类别归纳中具体与一般结论任务的ERP特征比较%Electrophysiological Differences Between Specific and General Conclusions During Category-Based Induction

    Institute of Scientific and Technical Information of China (English)

    李晓芳; 李婧; 龙长权

    2017-01-01

    In an experiment reported here,the event-related potential responses to specific conclusions (e.g.inference from apples having property X to bananas having property X) and general conclusions (e.g.inference from apples having property X to fruits having property X) were compared to reveal the implicit categorization in semantic memory by demonstrating the conclusion-specificity effects during category-based induction.The results showed that specific-and general-conclusion tasks elicited larger P2 amplitudes than did identical-conclusion tasks (e.g.inference from apples having property X to apples having property X),reflecting the analysis of orthographic representations for Chinese words.Specific-and general-conclusion tasks also elicited larger N2 and N400 components than did identical-conclusion tasks,reflecting perceptual mismatches.Moreover,the results showed that specific-conclusion arguments elicited smaller P3b than did general-conclusion tasks,reflecting higher load on working memory or lower degree of expectation satisfaction for specific-conclusion arguments during reasoning.Furthermore,the results showed that specific-conclusions elicited larger N400 components than did general-conclusions,suggesting the increasing cognitive effort for semantic integration for specific-conclusion arguments.These findings indicated that there were different event-related potential responses between specific-and general-conclusion arguments during category-based induction.%研究采用事件相关电位技术(ERPs),比较了具体结论类别归纳推理(例如,前提条件:苹果Xl,推论结论条件:梨子X1 7,即梨子是否也具有属性Xl)与一般结论类别归纳推理(例如,前提条件:苹果Xl,推论结论条件:水果X1 7,即水果是否也具有属性X1)的ERP特征差异.实验结果显示:与基线条件相比(例如,前提条件:苹果X1,推论结论条件:苹果X1?),具体和一般条件诱发了更大的P2,反映了具体与一般结论

  12. Preliminary Research on Grassland Fine-classification Based on MODIS

    International Nuclear Information System (INIS)

    Hu, Z W; Zhang, S; Yu, X Y; Wang, X S

    2014-01-01

    Grassland ecosystem is important for climatic regulation, maintaining the soil and water. Research on the grassland monitoring method could provide effective reference for grassland resource investigation. In this study, we used the vegetation index method for grassland classification. There are several types of climate in China. Therefore, we need to use China's Main Climate Zone Maps and divide the study region into four climate zones. Based on grassland classification system of the first nation-wide grass resource survey in China, we established a new grassland classification system which is only suitable for this research. We used MODIS images as the basic data resources, and use the expert classifier method to perform grassland classification. Based on the 1:1,000,000 Grassland Resource Map of China, we obtained the basic distribution of all the grassland types and selected 20 samples evenly distributed in each type, then used NDVI/EVI product to summarize different spectral features of different grassland types. Finally, we introduced other classification auxiliary data, such as elevation, accumulate temperature (AT), humidity index (HI) and rainfall. China's nation-wide grassland classification map is resulted by merging the grassland in different climate zone. The overall classification accuracy is 60.4%. The result indicated that expert classifier is proper for national wide grassland classification, but the classification accuracy need to be improved

  13. Reservations about the conclusions of the interdivisional (APA Divisions 12 & 29) task force on evidence-based therapy relationships: what do we know, what don't we know?

    Science.gov (United States)

    Kazantzis, Nikolaos; Cronin, Timothy J; Norton, Peter J; Lai, Jerry; Hofmann, Stefan G

    2015-05-01

    We offer a critical and constructive appraisal of the conclusions provided by the Interdivisional (American Psychological Association [APA] Divisions 12 & 29) Task Force on Evidence-Based Therapy Relationships. We highlight problems in overlapping terminology and definitions, as well as problems in the conduct of its meta-analyses (i.e., duplication of studies between reviews, inappropriate study inclusion, and use of measures of specific constructs for the calculation of effects for multiple relationship elements). On this basis, we express reservation about the conclusions offered by the APA Task Force. This special issue explores whether there are other therapeutic relationship elements that warrant consideration and further study. We were particularly interested in those elements that showed promise based on empirical or theoretical grounds, and in each article, we asked for an account of how the case formulation would guide the methods of adaptation for each individual client, and how the element would contribute to clinically relevant changes. © 2015 Wiley Periodicals, Inc.

  14. Informatics in radiology: web-based preliminary reporting system for radiology residents with PACS integration.

    Science.gov (United States)

    O'Connell, Timothy; Chang, Debra

    2012-01-01

    While on call, radiology residents review imaging studies and issue preliminary reports to referring clinicians. In the absence of an integrated reporting system at the training sites of the authors' institution, residents were typing and faxing preliminary reports. To partially automate the on-call resident workflow, a Web-based system for resident reporting was developed by using the free open-source xAMP Web application framework and an open-source DICOM (Digital Imaging and Communications in Medicine) software toolkit, with the goals of reducing errors and lowering barriers to education. This reporting system integrates with the picture archiving and communication system to display a worklist of studies. Patient data are automatically entered in the preliminary report to prevent identification errors and simplify the report creation process. When the final report for a resident's on-call study is available, the reporting system queries the report broker for the final report, and then displays the preliminary report side by side with the final report, thus simplifying the review process and encouraging review of all of the resident's reports. The xAMP Web application framework should be considered for development of radiology department informatics projects owing to its zero cost, minimal hardware requirements, ease of programming, and large support community.

  15. The RPC-based IFR system at BaBar experiment: preliminary results

    International Nuclear Information System (INIS)

    Piccolo, Davide; Palano, A.; Bagnasco, S.; Buzzo, A.; Contri, R.; Crosetti, G.; Lo Vetere, M.; Macri, M.; Monge, R.; Passaggio, S.; Patrignani, C.; Robutti, E.; Santroni, A.; Anulli, F.; Baldini, R.; Calcaterra, A.; De Sangro, R.; Falciai, D.; Finocchiaro, G.; Patteri, P.; Peruzzi, I.; Piccolo, M.; Yu, Z.; Zallo, A.; Cavallo, N.; De Nardo, G.; Fabozzi, F.; Gatto, C.; Lista, L.; Paolucci, P.; Sciacca, C.; Bionta, R.; Wright, D.; Band, H.; Johnson, J.

    2002-01-01

    The IFR system is a RPC-based detector used to identify muons and neutral hadrons in the BaBar experiment at PEP II machine in SLAC. The RPC system can be used to reconstruct the trajectory of muons, pions and neutral hadrons interacting in the iron of the IFR. The different range and hit pattern allow to discriminate different particles crossing the IFR. An overview of the system design and the preliminary results on the IFR performances are reported

  16. Preliminary Study of 20 MWth Experiment Power Reactor based on Pebble Bed Reactor

    Science.gov (United States)

    Irwanto, Dwi; Permana, Sidik; Pramuditya, Syeilendra

    2017-07-01

    In this study, preliminary design calculations for experimental small power reactor (20 MWt) based on Pebble Bed Reactor (PBR) are performed. PBR technology chosen due to its advantages in neutronic and safety aspects. Several important parameters, such as fissile enrichment, number of fuel passes, burnup and effective multiplication factor are taken into account in the calculation to find neutronic characteristics of the present reactor design.

  17. The RPC-based IFR system at BaBar experiment preliminary results

    CERN Document Server

    Piccolo, D; Bagnasco, S; Baldini, R; Band, H R; Bionta, R; Buzzo, A; Calcaterra, A; Cavallo, N; Contri, R; Crosetti, G; De Nardo, Gallieno; De Sangro, R; Fabozzi, F; Falciai, D; Finocchiaro, G; Gatto, C; Johnson, J; Lista, L; Lo Vetere, M; Macri, M; Monge, R; Palano, A; Paolucci, P; Passaggio, S; Patrignani, C; Patteri, P; Peruzzi, I; Piccolo, M; Robutti, E; Santroni, A; Sciacca, C; Wright, D; Yu, Z; Zallo, A

    2002-01-01

    The IFR system is a RPC-based detector used to identify muons and neutral hadrons in the BaBar experiment at PEP II machine in SLAC. The RPC system can be used to reconstruct the trajectory of muons, pions and neutral hadrons interacting in the iron of the IFR. The different range and hit pattern allow to discriminate different particles crossing the IFR. An overview of the system design and the preliminary results on the IFR performances are reported.

  18. Technology of prognostication of sporting achievements of badminton players on the stage of preliminary base preparation.

    Directory of Open Access Journals (Sweden)

    Shyyan V.N.

    2011-08-01

    Full Text Available In the article the technology of evaluation of potential capabilities of badminton players is displayed 12-14 years. The functional, pedagogical and psychophysiological criteria which became a component parts of the developed analytical models of sportsmen-badminton players are explored. The criterion for the quantitative estimation of perspective is offered, which allows on the 9-ti point scale to estimate perspective of badminton players on the stage of preliminary base preparation.

  19. Preliminary neutronic study on Pu-based OTTO cycle pebble bed reactor

    Energy Technology Data Exchange (ETDEWEB)

    Setiadipura, Topan; Zuhair [National Nuclear Energy Agency of Indonesia (BATAN), Selatan (Indonesia). Center for Nuclear Reactor Technology and Safety; Irwanto, Dwi [Bandung Institute of Technology (ITB), Bandung (Indonesia). Nuclear Physics and Biophysics Research Group

    2017-12-15

    The neutron physics characteristic of Pebble Bed Reactor (PBR) allows a better incineration of plutonium (Pu). An optimized design of simple PBR might give a symbiotic solution of providing a safe energy source, effective fuel utilization shown by a higher burnup value, and incineration of Pu stockpiles. This study perform a preliminary neutronic design study of a 200 MWt Once Through Then Out (OTTO) cycle PBR with Pu-based fuel. The safety criteria of the design were represented by the per-fuel-pebble maximum power generation of 4.5 kW/pebble. In this preliminary phase, the parametric survey is limited to the heavy metal (HM) loading per pebble and the average axial speed of the fuel. An optimum high burnup of 419.7 MWd/kg-HM was achieved in this study. This optimum design uses a HM loading of 2.5 g/pebble with average axial fuel velocity 0.5 cm/day.

  20. Development and preliminary evaluation of culturally specific web-based intervention for parents of adolescents.

    Science.gov (United States)

    Choi, H; Kim, S; Ko, H; Kim, Y; Park, C G

    2016-10-01

    WHAT IS KNOWN ON THE SUBJECT?: Problematic parent-child relationships have been identified as one of the main predictors of adolescents' mental health problems, but there are few existing interventions that address this issue. The format and delivery method of existing interventions for parents are relatively inaccessible for parents with full-time jobs and families living in rural areas. WHAT DOES THIS PAPER ADD TO EXISTING KNOWLEDGE?: The newly developed 'Stepping Stone' culturally specific web-based intervention, which is intended to help Korean parents of adolescents to acquire both knowledge and communication and conflict management skills, was found to be feasible and well-accepted by parents. This study enabled us to identify areas for improvement in the content and format of the intervention and strategies. This will potentially increase effect sizes for the outcome variables of parents' perception and behaviours. WHAT ARE THE IMPLICATIONS FOR PRACTICE?: This web-based intervention could be delivered across diverse settings, such as schools and community mental health centers, to increase parents' knowledge of adolescent's mental health and allow for early detection of mental health problems. Mental health nurses working in schools may spend a significant amount of time addressing students' mental health issues; thus, this web-based intervention could be a useful resource to share with parents and children. In this way, the mental health nurses could facilitate parental engagement in the intervention and then help them to continue to apply and practice the knowledge and skills obtained through the program. Introduction There is a need for accessible, culturally specific web-based interventions to address parent-child relationships and adolescents' mental health. Aims This study developed and conducted a preliminary evaluation of a 4-week web-based intervention for parents of adolescents aged 11 to 16 years in Korea. Methods We used a two-group, repeated

  1. Preliminary investigations on a NTP cargo shuttle for earth to moon orbit payload transfer based on a particle bed reactor

    International Nuclear Information System (INIS)

    Raepsaet, X.; Proust, E.; Gervaise, F.; Baraer, L.; Naury, S.; Linet, F.L.

    1995-01-01

    MAPS, a 3-year study program on NTP has recently been launched at CEA following the conclusions of a preliminary scoping study of an NTP system for earth to moon orbit cargo shuttle missions. This paper presents the main results of this scoping study, and gives an outline of the MAPS program. (authors). 5 figs., 11 tabs., 7 refs

  2. Preliminary investigations on a NTP cargo shuttle for earth to moon orbit payload transfer based on a particle bed reactor

    Energy Technology Data Exchange (ETDEWEB)

    Raepsaet, X; Proust, E; Gervaise, F; Baraer, L; Naury, S; Linet, F L [CEA Centre d` Etudes de Saclay, 91 - Gif-sur-Yvette (France). Dept. de Mecanique et de Technologie; Bresson, C F; Coriolis, C.C. de; Bergeron, I T.A.; Bourquin, L V; Clech, L V; Devaux, L V; Chevillot, L V; Augier, E V [EAMEA, 50 - Cherbourg (France)

    1995-12-01

    MAPS, a 3-year study program on NTP has recently been launched at CEA following the conclusions of a preliminary scoping study of an NTP system for earth to moon orbit cargo shuttle missions. This paper presents the main results of this scoping study, and gives an outline of the MAPS program. (authors). 5 figs., 11 tabs., 7 refs.

  3. Association between competing interests and authors' conclusions

    DEFF Research Database (Denmark)

    Kjaergard, Lise L; Als-Nielsen, Bodil

    2002-01-01

    To assess the association between competing interests and authors' conclusions in randomised clinical trials.......To assess the association between competing interests and authors' conclusions in randomised clinical trials....

  4. Gym-based exoskeleton walking: A preliminary exploration of non-ambulatory end-user perspectives.

    Science.gov (United States)

    Cahill, Aoife; Ginley, Orna Mc; Bertrand, Courtney; Lennon, Olive

    2018-07-01

    Robotic walking devices (RWD) have shown many physical benefits in Spinal Cord Injury (SCI) rehabilitation. No study to date has explored end-user perceptions of these devices or gained insight into the use of these devices in a gym-based setting. This preliminary study explores the perspectives of four non-ambulatory individuals with SCI on using an exoskeleton walking device in a gym-based community setting. In-depth, semi-structured interviews were conducted with four SCI individuals living in the community. Interviews were audio-recorded and transcribed verbatim. Inductive thematic analysis established common overarching themes and subthemes. Four primary themes emerged addressing "The Psychological Adjustments Around Using RWDs with Respect to Disability", "Perceived Physical, Social and Psychological Benefits of Using an Exoskeleton", "The Role of External Influences", and "A Wellness Model to Health". A fully integrated gym setting was found to provide a positive and encouraging space to utilise the device. In addition, both the ability to set training goals and the positive attitude of robotic trainers were deemed to be important factors. This preliminary study provides detailed perspectives of four non-ambulatory individuals with SCI on utilising an exoskeleton walking device in a community setting. It suggests that gym-based RWDs impact positively on the users' lives and enhance their perceived wellbeing and sense of community integration. Enabling access to similar, community-based facilities should be prioritised for those with longstanding SCI disability. Copyright © 2018 Elsevier Inc. All rights reserved.

  5. Preliminary Calculation for Plasma Chamber Design of Pulsed Electron Source Based on Plasma

    International Nuclear Information System (INIS)

    Widdi Usada

    2009-01-01

    This paper described the characteristics of pulsed electron sources with anode-cathode distance of 5 cm, electrode diameter of 10 cm, driven by capacitor energy of 25 J. The preliminary results showed that if the system is operated with diode resistance is 1.6 Ω, plasma resistance is 0.14 Ω, and β is 0.94, the achieved of plasma voltage is 640 V, its current is 4.395 kA with its pulse width of 0.8 μsecond. According to breakdown voltage based on Paschen empirical formula, with this achieved voltage, this system could be operated for operation pressure of 1 torr. (author)

  6. Conclusions regarding geotechnical acceptability of the WIPP site

    International Nuclear Information System (INIS)

    Weart, W.D.

    1983-01-01

    The Waste Isolation Pilot Plant (WIPP) was authorized by Congress in 1980 as an unlicensed research and development (R and D) facility to demonstrate the safe disposal of radioactive wastes arising from the defense activities and programs of the United States. WIPP is now being constructed in southeast New Mexico, using salt beds about 655 m below the surface of the ground. Construction of the full WIPP facility will not commence until a preliminary underground excavation phase, called Site and Preliminary Design Validation (SPDV), is satisfactorily concluded in the summer of 1983. This SPDV program permits confirmation of subsurface geology, in drifts at planned facility depth that extend for 1555 m in a north-south direction, and in the two vertical shafts that provide access to these drifts. The subsurface studies are nearing completion, and it is therefore appropriate to draw conclusions regarding the geotechnical acceptability of the WIPP site. Four geotechnical elements are discussed: dissolution, deformation, hydrologic regime, and natural resources

  7. Imaging-based surrogate markers of transcriptome subclasses and signatures in hepatocellular carcinoma. Preliminary results

    International Nuclear Information System (INIS)

    Taouli, Bachir; Hoshida, Yujin; Chen, Xintong; Sun, Xiaochen; Kojima, Kensuke; Toffanin, Sara; Hirschfield, Hadassa; Kakite, Suguru; Tan, Poh Seng; Kihira, Shingo; Fiel, M.I.; Wagner, Mathilde; Llovet, Josep M.

    2017-01-01

    In this preliminary study, we examined whether imaging-based phenotypes are associated with reported predictive gene signatures in hepatocellular carcinoma (HCC). Thirty-eight patients (M/F 30/8, mean age 61 years) who underwent pre-operative CT or MR imaging before surgery as well as transcriptome profiling were included in this IRB-approved single-centre retrospective study. Eleven qualitative and four quantitative imaging traits (size, enhancement ratios, wash-out ratio, tumour-to-liver contrast ratios) were assessed by three observers and were correlated with 13 previously reported HCC gene signatures using logistic regression analysis. Thirty-nine HCC tumours (mean size 5.7 ± 3.2 cm) were assessed. Significant positive associations were observed between certain imaging traits and gene signatures of aggressive HCC phenotype (G3-Boyault, Proliferation-Chiang profiles, CK19-Villanueva, S1/S2-Hoshida) with odds ratios ranging from 4.44-12.73 (P <0.045). Infiltrative pattern at imaging was significantly associated with signatures of microvascular invasion and aggressive phenotype. Significant but weak associations were also observed between each enhancement ratio and tumour-to-liver contrast ratios and certain gene expression profiles. This preliminary study demonstrates a correlation between phenotypic imaging traits with gene signatures of aggressive HCC, which warrants further prospective validation to establish imaging-based surrogate markers of molecular phenotypes in HCC. (orig.)

  8. Imaging-based surrogate markers of transcriptome subclasses and signatures in hepatocellular carcinoma. Preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Taouli, Bachir [Icahn School of Medicine at Mount Sinai, Department of Radiology, New York, NY (United States); Icahn School of Medicine at Mount Sinai, Translational and Molecular Imaging Institute, New York, NY (United States); Icahn School of Medicine at Mount Sinai, Liver Cancer Program, Tisch Cancer Institute, New York, NY (United States); Hoshida, Yujin; Chen, Xintong; Sun, Xiaochen; Kojima, Kensuke; Toffanin, Sara; Hirschfield, Hadassa [Icahn School of Medicine at Mount Sinai, Liver Cancer Program, Tisch Cancer Institute, New York, NY (United States); Icahn School of Medicine at Mount Sinai, Division of Liver Diseases, Department of Medicine, New York, NY (United States); Kakite, Suguru [Icahn School of Medicine at Mount Sinai, Translational and Molecular Imaging Institute, New York, NY (United States); Tottori University, Division of Radiology, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Yonago City (Japan); Tan, Poh Seng [Icahn School of Medicine at Mount Sinai, Liver Cancer Program, Tisch Cancer Institute, New York, NY (United States); Icahn School of Medicine at Mount Sinai, Division of Liver Diseases, Department of Medicine, New York, NY (United States); National University Health System, Division of Gastroenterology and Hepatology, University Medicine Cluster, Singapore (Singapore); Kihira, Shingo [Icahn School of Medicine at Mount Sinai, Department of Radiology, New York, NY (United States); Fiel, M.I. [Icahn School of Medicine at Mount Sinai, Department of Pathology, New York, NY (United States); Wagner, Mathilde [Icahn School of Medicine at Mount Sinai, Translational and Molecular Imaging Institute, New York, NY (United States); Sorbonne Universites, UPMC, Department of Radiology, Hopital Pitie-Salpetriere, Paris (France); Llovet, Josep M. [Icahn School of Medicine at Mount Sinai, Liver Cancer Program, Tisch Cancer Institute, New York, NY (United States); Icahn School of Medicine at Mount Sinai, Division of Liver Diseases, Department of Medicine, New York, NY (United States); Universitat de Barcelona, HCC Translational Research Laboratory, Barcelona-Clinic Liver Cancer Group Institut d' Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona (Spain); Institucio Catalana de Recerca i Estudis Avancats, Barcelona (Spain)

    2017-11-15

    In this preliminary study, we examined whether imaging-based phenotypes are associated with reported predictive gene signatures in hepatocellular carcinoma (HCC). Thirty-eight patients (M/F 30/8, mean age 61 years) who underwent pre-operative CT or MR imaging before surgery as well as transcriptome profiling were included in this IRB-approved single-centre retrospective study. Eleven qualitative and four quantitative imaging traits (size, enhancement ratios, wash-out ratio, tumour-to-liver contrast ratios) were assessed by three observers and were correlated with 13 previously reported HCC gene signatures using logistic regression analysis. Thirty-nine HCC tumours (mean size 5.7 ± 3.2 cm) were assessed. Significant positive associations were observed between certain imaging traits and gene signatures of aggressive HCC phenotype (G3-Boyault, Proliferation-Chiang profiles, CK19-Villanueva, S1/S2-Hoshida) with odds ratios ranging from 4.44-12.73 (P <0.045). Infiltrative pattern at imaging was significantly associated with signatures of microvascular invasion and aggressive phenotype. Significant but weak associations were also observed between each enhancement ratio and tumour-to-liver contrast ratios and certain gene expression profiles. This preliminary study demonstrates a correlation between phenotypic imaging traits with gene signatures of aggressive HCC, which warrants further prospective validation to establish imaging-based surrogate markers of molecular phenotypes in HCC. (orig.)

  9. Effects of sensitive electrical stimulation based cueing in Parkinson's disease: a preliminary study

    Directory of Open Access Journals (Sweden)

    Benoît Sijobert

    2016-06-01

    Full Text Available This study aims to investigate the effect of a sensitive cueing on Freezing of Gait (FOG and gait disorders in subjects suffering from Parkinson’s disease (PD. 13 participants with Parkinson’s disease were equipped with an electrical stimulator and a foot mounted inertial measurement unit (IMU. An IMU based algorithm triggered in real time an electrical stimulus applied on the arch of foot at heel off detection. Starting from standing, subjects were asked to walk at their preferred speed on a path comprising 5m straight, u-turn and walk around tasks. Cueing globally decreased the time to achieve the different tasks in all the subjects. In “freezer” subjects, the time to complete the entire path was reduced by 19%. FOG events occurrence was lowered by 12% compared to baseline before and after cueing. This preliminary work showed a positive global effect of an electrical stimulation based cueing on gait and FOG in PD.

  10. The development and preliminary testing of new boronated agents for BNCT based on PET derived data

    International Nuclear Information System (INIS)

    Nichols, T.; Kabalka, G.; Kahn, M.; Das, B.; Das, S.; Bao, W.; Miller, L.

    2000-01-01

    Positron emission tomography (PET) has been utilized at the University of Tennessee for evaluating a variety of tumors including glioblastoma multiforme (GBM) and metastatic malignant melanoma (MM). Studies have been carried out utilizing fluorine-18 labeled p-boronophenylalanine ( 18 F-BPA) and other unnatural amino acids. A comparison of PET studies obtained using 18 F-BPA and a carbon-11 labeled cyclobutane-based amino acid ( 11 C-ACBC) revealed that 11 C-ACBC localized effectively in GBM tumors. Based on these results, we have prepared a series of boronated, aminocyclobutanecarboxylic acids. Preliminary uptake and cell toxicity studies have been carried out and show that many of the agents are not toxic. In one instance, a biodistribution study carried out using nude mice implanted with a human glioblastoma tumor, the tumor to normal tissue uptake of boron exceeds that observed for BPA. (author)

  11. Preliminary Investigations into the Development of Textile Based Temperature Sensor for Healthcare Applications

    Directory of Open Access Journals (Sweden)

    Richard Kennon

    2013-04-01

    Full Text Available Human body temperature is an important sign of physical condition in terms of comfort, heat or cold stresses, and of performance. This paper presents the preliminary investigation into the design, manufacturing and testing of the textile based temperature sensor. This sensing fabric may be employed to measure the temperature of the human body on a continuous basis over extensive periods of time, outside the clinical environment. The sensing fabric was manufactured on an industrial scale flat-bed knitting machine by laying-in the sensing element (in the form of fine metal wire into the double layer knitted structure. The operational principle of the sensing fabric is based on the inherent tendency of metal wire to change in its electrical resistance because of the change in its temperature. An experimental resistance-temperature relationship showed promising validation in comparison with their modeled counterparts.

  12. Only one simple conclusion about the climate

    Energy Technology Data Exchange (ETDEWEB)

    Jaremko, G.

    2000-07-24

    Findings concerning climate change, by a three-man team of scientists from the North Dakota Geological Survey, which were presented in a paper read at the Eight International Williston Basin Horizontal Well Workshop, are discussed. The survey by the three scientists covered more than 6,000 scholarly publications. It reported that while the rise in the Earth's temperature is beyond argument, there is anything but agreement as to the causes, or whether the trend is unusual enough to justify concerted and costly actions to change lifestyles. It is shown by direct instrumental measurements that the average temperature at the Earth's surface increased about 0.8 degree Celsius between 1866 and 1998. During that time the concentration of carbon dioxide in the atmosphere increased from 280 to 353 parts per million. While it is generally assumed that the global warming was caused by human activities, new techniques of measurement such as glacier ice coring, dendrochronology (tree-growth rings), lichenometry (measuring the diameter of lichens) and counting concentrations of oxygen 18 and 16 (isotopes whose presence in marine fossils varies depending on temperature) suggest that most of the global warming took place before the increase in carbon dioxide concentration occurred, raising the possibility that the increase in average temperature had causes other than the increase in greenhouse gases. Some of the studies reviewed by the group show that in Europe between ice ages during the Eemian period, some 135,000 to 110,000 years ago, temperature variations of seven degrees Celsius took place; they dropped from two degree Celsius warmer than today to five degree Celsius colder than today. Based on these findings the group's only firm conclusion was that climate is in a continual flux.

  13. Preliminary investigation of airgap electrospun silk-fibroin-based structures for ligament analogue engineering.

    Science.gov (United States)

    Sell, S A; McClure, M J; Ayres, C E; Simpson, D G; Bowlin, G L

    2011-01-01

    The process of electrospinning has proven to be highly beneficial for use in a number of tissue-engineering applications due to its ease of use, flexibility and tailorable properties. There have been many publications on the creation of aligned fibrous structures created through various forms of electrospinning, most involving the use of a metal target rotating at high speeds. This work focuses on the use of a variation known as airgap electrospinning, which does not use a metal collecting target but rather a pair of grounded electrodes equidistant from the charged polymer solution to create highly aligned 3D structures. This study involved a preliminary investigation and comparison of traditionally and airgap electrospun silk-fibroin-based ligament constructs. Structures were characterized with SEM and alignment FFT, and underwent porosity, permeability, and mechanical anisotropy evaluation. Preliminary cell culture with human dermal fibroblasts was performed to determine the degree of cellular orientation and penetration. Results showed airgap electrospun structures to be anisotropic with significantly increased porosity and cellular penetration compared to their traditionally electrospun counterparts.

  14. Smartphone-based fluorescence spectroscopy device aiding in preliminary skin screening

    Science.gov (United States)

    Sahoo, Aparajita; Wahi, Akshat; Das, Anshuman

    2018-02-01

    Preliminary diagnosis of closely resembling skin conditions can be highly subjective for dermatologists. In ambiguous cases, it often leads to performing invasive procedures like biopsies. Different skin conditions, however, have varying concentrations of fluorophores (like collagen, NADH) and chromophores (like melanin, hemoglobin) which can alter their fluorescence spectra. We demonstrate a handheld, portable, smartphone-based spectrometer that leverages these alterations in skin autofluorescence spectra for rapid screening of skin conditions. This methodology involves excitation of affected skin areas with ultraviolet (UV-A) 385 nm light, capturing the generated fluorescence spectra and sending the data wirelessly to a companion mobile application for data storage, analysis and visualization. By collecting the fluorescence spectral signals from healthy and unhealthy skin conditions, we establish that the signals collected using this portable device can be used to develop a classification method to help in differentially diagnosing these conditions. It shows promise as a useful skin screening tool for both dermatologists and primary health care workers. This device can enable quick, non-invasive and a more objective preliminary examination. We envision the device to be especially useful in primary healthcare centers of developing countries where availability of dermatologists is limited.

  15. 1972 preliminary safety analysis report based on a conceptual design of a proposed repository in Kansas

    International Nuclear Information System (INIS)

    Blomeke, J.O.

    1977-08-01

    This preliminary safety analysis report is based on a proposed Federal Repository at Lyons, Kansas, for receiving, handling, and depositing radioactive solid wastes in bedded salt during the remainder of this century. The safety analysis applies to a hypothetical site in central Kansas identical to the Lyons site, except that it is free of nearby salt solution-mining operations and bore holes that cannot be plugged to Repository specifications. This PSAR contains much information that also appears in the conceptual design report. Much of the geological-hydrological information was gathered in the Lyons area. This report is organized in 16 sections: considerations leading to the proposed Repository, design requirements and criteria, a description of the Lyons site and its environs, land improvements, support facilities, utilities, different impacts of Repository operations, safety analysis, design confirmation program, operational management, requirements for eventually decommissioning the facility, design criteria for protection from severe natural events, and the proposed program of experimental investigations

  16. Preliminary analysis of a membrane-based atmosphere-control subsystem

    Science.gov (United States)

    Mccray, Scott B.; Newbold, David D.; Ray, Rod; Ogle, Kathryn

    1993-01-01

    Controlled ecological life supprot systems will require subsystems for maintaining the consentrations of atmospheric gases within acceptable ranges in human habitat chambers and plant growth chambers. The goal of this work was to develop a membrane-based atmosphere comntrol (MBAC) subsystem that allows the controlled exchange of atmospheric componets (e.g., oxygen, carbon dioxide, and water vapor) between these chambers. The MBAC subsystem promises to offer a simple, nonenergy intensive method to separate, store and exchange atmospheric components, producing optimal concentrations of components in each chamber. In this paper, the results of a preliminary analysis of the MBAC subsystem for control of oxygen and nitrogen are presented. Additionally, the MBAC subsystem and its operation are described.

  17. Preliminary development and evaluation of an algae-based air regeneration system

    Science.gov (United States)

    Nienow, J. A.

    2000-01-01

    The potential of air regeneration system based on the growth of microalgae on the surface of porous ceramic tubes is evaluated. The algae have been maintained in the system for extended periods, up to 360 days. Preliminary measurements of the photosynthetic capacity have been made for Chlorella vulgaris (UTEX 259), Neospongiococcum punctatum (UTEX 786), Stichococcus sp., and Gloeocapsa sp. Under standard test conditions (photosynthetic photon flux approximately 66 micromoles m-2 s-1, initial CO2 concentration approximately 450 micromoles mol-1), mature tubes remove up to 0.2 micromoles of CO2 per tube per minute. The rate of removal increases with photon flux up to at least 225 micromoles m-2 s-1 (PPF); peak rates of 0.35 micromoles of CO2 per tube per minute have been achieved with Chlorella vulgaris. These rates correspond to between 120 and 210 micromoles of CO2 removed per square meter of projected area per minute.

  18. Preliminary studi on neutronic aspect of a conceptual design of the Kartini reactor base ADS facility

    International Nuclear Information System (INIS)

    Tegas Sutondo

    2012-01-01

    A preliminary study on neutronic aspect of a conceptual design of ADS facility with the basis of Kartini Reaktor, has been performed. The study was intended to see the feasibility from neutronic point of view of Kartini reactor, to be used as a small scale of NPP’s waste transmutation experimental facility. A SRAC code was used as the basis of calculations. The results indicate that the presence of minor actinides (MA) will give a positive reactivity, which tends to increase with the increase of MA concentrations. Based on the defined criteria of subcriticality and by considering the core power distributions and the level of reactivity contribution of MA element, it is concluded that Kartini reactor is potential enough to be used as an ADS experimental facility, mainly for MA concentration between 30 to 50 % of the assumed mixture of C-MA matrix. (author)

  19. 1972 preliminary safety analysis report based on a conceptual design of a proposed repository in Kansas

    Energy Technology Data Exchange (ETDEWEB)

    Blomeke, J.O.

    1977-08-01

    This preliminary safety analysis report is based on a proposed Federal Repository at Lyons, Kansas, for receiving, handling, and depositing radioactive solid wastes in bedded salt during the remainder of this century. The safety analysis applies to a hypothetical site in central Kansas identical to the Lyons site, except that it is free of nearby salt solution-mining operations and bore holes that cannot be plugged to Repository specifications. This PSAR contains much information that also appears in the conceptual design report. Much of the geological-hydrological information was gathered in the Lyons area. This report is organized in 16 sections: considerations leading to the proposed Repository, design requirements and criteria, a description of the Lyons site and its environs, land improvements, support facilities, utilities, different impacts of Repository operations, safety analysis, design confirmation program, operational management, requirements for eventually decommissioning the facility, design criteria for protection from severe natural events, and the proposed program of experimental investigations. (DLC)

  20. Moral hazard, doctors, and absenteism in France. Preliminary analysis based on aggregate data.

    Science.gov (United States)

    Grignon, M; Renaud, T

    2007-08-01

    This article provides a simple and preliminary study of variations in the number of days of work lost to illness and injury in France, over time and across jurisdictions. We test the hypothesis that workers use their physicians to cheat the system and increase their leisure time paid for by the sickness fund. Firstly, using time series analysis, we check that change in the unemployment rate correlates unequivocally and negatively with the absence rate. We then show, based on geographical aggregate level data, that physicians' density is not positively correlated to sick leaves, which runs contrary to the idea of cheating helped by doctors. We suggest and test for alternative factors, such as baseline population health. If the increase in the number of days lost to illness is seen as a matter of concern, our recommended policy would be to target demand side as well as supply side in the labour market.

  1. A Controlled Randomized Preliminary Trial of a Modified Dissonance-Based Eating Disorder Intervention Program.

    Science.gov (United States)

    Green, M A; Willis, M; Fernandez-Kong, K; Reyes, S; Linkhart, R; Johnson, M; Thorne, T; Lindberg, J; Kroska, E; Woodward, H

    2017-12-01

    We conducted a controlled randomized preliminary trial of a modified dissonance-based eating disorder program (n = 24) compared to an assessment-only control condition (n = 23) via a longitudinal design (baseline, postintervention, 2-month follow-up) in a community sample of women (N = 47) with clinical (n = 22) and subclinical (n = 25) eating disorder symptoms. The traditional content of the Body Project, a dissonance-based eating disorder prevention program, was modified to include verbal, written, and behavioral exercises designed to dissuade self-objectification and maladaptive social comparison. Women with clinical and subclinical symptoms were included in the target audience to investigate both the treatment and the indicated prevention utility of the modified dissonance program. Body dissatisfaction, self-esteem, self-objectification, thin-ideal internalization, maladaptive social comparison, trait anxiety, and eating disorder symptoms were evaluated in the control and the modified dissonance condition at baseline, postintervention, and 2-month follow-up. We predicted a statistically significant 2 (condition: control, modified dissonance) x 3 (time: baseline, postintervention, 2-month follow-up) interaction in the mixed factorial multivariate analyses of variance results. Results confirmed this hypothesis. Eating disorder risk factors and symptoms decreased significantly among participants in the modified dissonance condition at postintervention and 2-month follow-up compared to baseline; symptom improvement was greater among participants in the modified compared to the control condition. A secondary analysis indicated symptom improvement did not vary as a function of symptom status (clinical, subclinical), suggesting the program is efficacious in both indicated prevention and treatment applications. Results provide preliminary support for the modified dissonance program. © 2017 Wiley Periodicals, Inc.

  2. Data, Model, Conclusions, Doing It Again.

    Science.gov (United States)

    Molenaar, Ivo W.

    1998-01-01

    Explores the robustness of conclusions from a statistical model against variations in model choice with an illustration from G. Box and G. Tiao (1973). Suggests that simultaneous consideration of a class of models for the same data is sometimes superior to analyzing the data under one model and demonstrates advantages to Adaptive Bayesian…

  3. Premature conclusions about psychotherapy for dysthymia

    NARCIS (Netherlands)

    Cuijpers, P.

    2009-01-01

    Dr Cuijpers and Colleagues Reply To the Editor: We thank Dr Gaudiano and colleagues for their contribution to the discussion about psychotherapy for dysthymia. We agree very much with Gaudiano et al that we should be careful about drawing definite conclusions about the comparative efficacy of

  4. Data, model, conclusion, doing it again

    NARCIS (Netherlands)

    Molenaar, W.

    1998-01-01

    This paper explores the robustness of conclusions from a statistical model against variations in model choice (rather than variations in random sampling and random assignment to treatments, which are the usual variations covered by inferential statistics). After the problem formulation in section 1,

  5. Results and conclusion; Resultados e conclusoes

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-10-15

    This chapter shows the results and conclusions of the ordered studies by the Science and Technology Ministry from Brazil to the Center of Management and Strategic Studies (CGEE), executed by a multidisciplinary team, most of UNICAMP - State University of Campinas, SP - for evaluation of Brazilian capacity and potential in the production of fuel bioethanol.

  6. Venturing into the private sector: Conclusion

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    From the very beginning, HEU has been a government-to-government deal. And right fully so. These weapons were produced by the US and Russia over the course of the Cold War. The two superpowers should play the main role in their dismantlement. After all, these aren't cars or microcomputers we're talking about. They are weapons of mass destruction. One day, private business will profit from their dismantlement. But it is truly the responsibility of the US and Russian governments to accomplish the larger objective of the HEU deal: To destroy these weapons, once and for all. But if government can fulfill the role of moral overseer, there's no reason why the private sector should not be involved in implementing the plan. And there is no shortage of companies lining up for a piece of the business. The Russians are all ears. While a deal with the US is their main priority, they've spoken to a number of private companies about blending down and marketing the HEU. In recent months, several US companies have signed preliminary agreements with the Russians. But what actual business these agreements will lead to is very unclear

  7. Description of the Northwest hazardous waste site data base and preliminary analysis of site characteristics

    International Nuclear Information System (INIS)

    Woodruff, D.L.; Hartz, K.E.; Triplett, M.B.

    1988-08-01

    The Northwest Hazardous Waste RD and D Center (the Center) conducts research, development, and demonstration (RD and D) activities for hazardous and radioactive mixed-waste technologies applicable to remediating sites in the states of Idaho, Montana, Oregon, and Washington. To properly set priorities for these RD and D activities and to target development efforts it is necessary to understand the nature of the sites requiring remediation. A data base of hazardous waste site characteristics has been constructed to facilitate this analysis. The data base used data from EPA's Region X Comprehensive Environmental Response, Compensation, and Liability Information System (CERCLIS) and from Preliminary Assessment/Site Investigation (PA/SI) forms for sites in Montana. The Center's data base focuses on two sets of sites--those on the National Priorities List (NPL) and other sites that are denoted as ''active'' CERCLIS sites. Active CERCLIS sites are those sites that are undergoing active investigation and analysis. The data base contains information for each site covering site identification and location, type of industry associated with the site, waste categories present (e.g., heavy metals, pesticides, etc.), methods of disposal (e.g., tanks, drums, land, etc.), waste forms (e.g., liquid, solid, etc.), and hazard targets (e.g., surface water, groundwater, etc.). As part of this analysis, the Northwest region was divided into three geographic subregions to identify differences in disposal site characteristics within the Northwest. 2 refs., 18 figs., 5 tabs

  8. Power and Democracy in Denmark. Conclusions

    DEFF Research Database (Denmark)

    Andersen, Jørgen Goul; Christiansen, Peter Munk; Beck Jørgensen, Torben

    In 1997, the Danish Parliament decided to launch a power study, officially An Analysis of Democracy and Power in Denmark. A steering committee consisting of five independent researchers was assigned responsibility for the project. The Steering Committee has gathered the overall conclusions from...... the numerous projects under the Power Study, and this book is a short presentation of these conclusions.The main focus of the book is the state of democracy in Denmark at the dawn of the 21st century. How has democracy fared, has the development made things better or worse, and to which extent does......, and the political institutions show considerable democratic robustness. However, not everything has gone or is going well. There are still pronounced social divisions in Danish society, although their nature has changed somewhat. The ideal of an informed public debate does not always enjoy the best conditions...

  9. DWI-Based Neural Fingerprinting Technology: A Preliminary Study on Stroke Analysis

    Directory of Open Access Journals (Sweden)

    Chenfei Ye

    2014-01-01

    Full Text Available Stroke is a common neural disorder in neurology clinics. Magnetic resonance imaging (MRI has become an important tool to assess the neural physiological changes under stroke, such as diffusion weighted imaging (DWI and diffusion tensor imaging (DTI. Quantitative analysis of MRI images would help medical doctors to localize the stroke area in the diagnosis in terms of structural information and physiological characterization. However, current quantitative approaches can only provide localization of the disorder rather than measure physiological variation of subtypes of ischemic stroke. In the current study, we hypothesize that each kind of neural disorder would have its unique physiological characteristics, which could be reflected by DWI images on different gradients. Based on this hypothesis, a DWI-based neural fingerprinting technology was proposed to classify subtypes of ischemic stroke. The neural fingerprint was constructed by the signal intensity of the region of interest (ROI on the DWI images under different gradients. The fingerprint derived from the manually drawn ROI could classify the subtypes with accuracy 100%. However, the classification accuracy was worse when using semiautomatic and automatic method in ROI segmentation. The preliminary results showed promising potential of DWI-based neural fingerprinting technology in stroke subtype classification. Further studies will be carried out for enhancing the fingerprinting accuracy and its application in other clinical practices.

  10. DWI-based neural fingerprinting technology: a preliminary study on stroke analysis.

    Science.gov (United States)

    Ye, Chenfei; Ma, Heather Ting; Wu, Jun; Yang, Pengfei; Chen, Xuhui; Yang, Zhengyi; Ma, Jingbo

    2014-01-01

    Stroke is a common neural disorder in neurology clinics. Magnetic resonance imaging (MRI) has become an important tool to assess the neural physiological changes under stroke, such as diffusion weighted imaging (DWI) and diffusion tensor imaging (DTI). Quantitative analysis of MRI images would help medical doctors to localize the stroke area in the diagnosis in terms of structural information and physiological characterization. However, current quantitative approaches can only provide localization of the disorder rather than measure physiological variation of subtypes of ischemic stroke. In the current study, we hypothesize that each kind of neural disorder would have its unique physiological characteristics, which could be reflected by DWI images on different gradients. Based on this hypothesis, a DWI-based neural fingerprinting technology was proposed to classify subtypes of ischemic stroke. The neural fingerprint was constructed by the signal intensity of the region of interest (ROI) on the DWI images under different gradients. The fingerprint derived from the manually drawn ROI could classify the subtypes with accuracy 100%. However, the classification accuracy was worse when using semiautomatic and automatic method in ROI segmentation. The preliminary results showed promising potential of DWI-based neural fingerprinting technology in stroke subtype classification. Further studies will be carried out for enhancing the fingerprinting accuracy and its application in other clinical practices.

  11. Preliminary Evaluation of a Practice-Based EBVM Skills Development Program

    Directory of Open Access Journals (Sweden)

    Ava Firth

    2016-12-01

    Full Text Available Whilst there is a small body of research that investigates the development of EBVM skills in veterinary undergraduates there is a paucity of research that aims to understand the development of EBVM skills in practice-based post-graduate veterinary surgeons. This paper is a small step in remedying that shortfall. In particular, the paper provides a progress report on an RCVS Knowledge funded study that is evaluating a practice-based EBVM development program. The program is being conducted with a cohort of 20 veterinary surgeons and veterinary nurses employed in a private practice veterinary company across multiple sites. The facilitated instruction approach incorporates multiple supports including; group based and one-to-one, synchronous and asynchronous, and, face-to-face and online strategies. This paper will provide details of both the facilitation and evaluation approaches that have been adopted. The paper will also report on preliminary results of the evaluation which focuses on barriers and facilitators to EBVM development.This is a podcast of Ava and Ian's talk at the Veterinary Evidence Today conference, Edinburgh November 2, 2016.

  12. Preliminary studies on the utilisation of Berea Red Sands for sub-base and base construction

    CSIR Research Space (South Africa)

    Bergh, AO

    2008-07-01

    Full Text Available Berea Red sands occur in abundance on the eastern seaboard of KwaZulu-Natal and Mozambique. The material is of Aeolian origin and is seldom used as base and sub-base material in the region, even on lightly trafficked roads. The main reasons...

  13. Superiority in value and the repugnant conclusion

    DEFF Research Database (Denmark)

    Jensen, Karsten Klint

    2007-01-01

    superiority does not amount to a radical value difference at all. I then spell out the consequences of these results for different interpretations of Griffin's suggestion regarding population ethics. None of them comes out very successful, but perhaps they nevertheless retain some interest.......James Griffin has considered a weak form of superiority in value a possible remedy to the Repugnant Conclusion. In this paper, I demonstrate that, in a context where value is additive, this weaker form collapses into a stronger form of superiority. And in a context where value is non-additive, weak...

  14. Preliminary safety evaluation, based on initial site investigation data. Planning document

    International Nuclear Information System (INIS)

    Hedin, Allan

    2002-12-01

    This report is a planning document for the preliminary safety evaluations (PSE) to be carried out at the end of the initial stage of SKBs ongoing site investigations for a deep repository for spent nuclear fuel. The main purposes of the evaluations are to determine whether earlier judgements of the suitability of the candidate area for a deep repository with respect to long-term safety holds up in the light of borehole data and to provide feed-back to continued site investigations and site specific repository design. The preliminary safety evaluations will be carried out by a safety assessment group, based on a site model, being part of a site description, provided by a site modelling group and a repository layout within that model suggested by a repository engineering group. The site model contains the geometric features of the site as well as properties of the host rock. Several alternative interpretations of the site data will likely be suggested. Also the biosphere is included in the site model. A first task for the PSE will be to compare the rock properties described in the site model to previously established criteria for a suitable host rock. This report gives an example of such a comparison. In order to provide more detailed feedback, a number of thermal, hydrological, mechanical and chemical analyses of the site will also be included in the evaluation. The selection of analyses is derived from the set of geosphere and biosphere analyses preliminarily planned for the comprehensive safety assessment named SR-SITE, which will be based on a complete site investigation. The selection is dictated primarily by the expected feedback to continued site investigations and by the availability of data after the PSE. The repository engineering group will consider several safety related factors in suggesting a repository layout: Thermal calculations will be made to determine a minimum distance between canisters avoiding canister surface temperatures above 100 deg C

  15. Effectiveness of collage activity based on a life review in elderly cancer patients: A preliminary study.

    Science.gov (United States)

    Sakaguchi, Satoko; Okamura, Hitoshi

    2015-04-01

    Much of the cancer rehabilitation research that has been conducted has consisted of relatively early recovery-of-function rehabilitation, and little attention has been paid to the psychosocial aspects of palliative rehabilitation. The aim of the present preliminary study was to examine the "narratives" of elderly cancer patients that emerged as a result of a life review performed in association with collage activity and to assess the effectiveness of this intervention. We conducted a collage activity based on a life review in two sessions. Some 11 cancer patients who were 65 years of age or older and receiving palliative care participated. Evaluations using the Functional Assessment of Chronic Illness Therapy-Spiritual (FACIT-Sp) Scale, the Hospital Anxiety and Depression Scale (HADS), and the Self-Efficacy Scale for Terminal Cancer (SESTC) were administered before and immediately after the intervention. The mean scores for the FACIT-Sp and affect regulation efficacy on the SESTC significantly increased, while the mean HADS score significantly decreased. Regarding the impressions after completion of the intervention, generally favorable evaluations were heard from families and medical staff members as well as from the subjects. A collage activity based on a life review may be effective for improving spiritual well-being, mitigating anxiety and depression, and improving self-efficacy. The collage itself was also useful in facilitating interactions with others, including family members, and the activity provided psychological support for families.

  16. THE EFFECTIVENESS OF PANORAMIC MAPS DESIGN: A PRELIMINARY STUDY BASED ON MOBILE EYE-TRACKING

    Directory of Open Access Journals (Sweden)

    R. Balzarini

    2016-06-01

    Full Text Available This paper presents preliminary results from an ongoing research based on the study of visual attention through mobile eye-tracking techniques. The visual-cognitive approach investigates the reading-comprehension of a particular territorial representation: ski trails maps. The general issue of the study is to provide insights about the effectiveness of panoramic ski maps and more broadly, to suggest innovative efficient representation of the geographic information in mountain. According to some mountain operators, the information provided by paper ski maps no longer meets the needs of a large part of the customers; the question now arises of their adaptation to new digital practices (iPhone, tablets. In a computerized process perspective, this study particularly focuses on the representations, and the inferred information, which are really helpful to the users-skiers to apprehend the territory and make decisions, and which could be effectively replicated into a digital system. The most interesting output relies on the relevance of the panorama view: panorama still fascinates, but contrary to conventional wisdom, the information it provides does not seem to be useful to the skier. From a socio-historical perspective this study shows how empirical evidence-based approach can support the change: our results enhance the discussion on the effectiveness of the message that mountain operators want to convey to the tourist and therefore, on the renewal of (geographical information in ski resorts.

  17. The Effectiveness of Panoramic Maps Design: a Preliminary Study Based on Mobile Eye-Tracking

    Science.gov (United States)

    Balzarini, R.; Murat, M.

    2016-06-01

    This paper presents preliminary results from an ongoing research based on the study of visual attention through mobile eye-tracking techniques. The visual-cognitive approach investigates the reading-comprehension of a particular territorial representation: ski trails maps. The general issue of the study is to provide insights about the effectiveness of panoramic ski maps and more broadly, to suggest innovative efficient representation of the geographic information in mountain. According to some mountain operators, the information provided by paper ski maps no longer meets the needs of a large part of the customers; the question now arises of their adaptation to new digital practices (iPhone, tablets). In a computerized process perspective, this study particularly focuses on the representations, and the inferred information, which are really helpful to the users-skiers to apprehend the territory and make decisions, and which could be effectively replicated into a digital system. The most interesting output relies on the relevance of the panorama view: panorama still fascinates, but contrary to conventional wisdom, the information it provides does not seem to be useful to the skier. From a socio-historical perspective this study shows how empirical evidence-based approach can support the change: our results enhance the discussion on the effectiveness of the message that mountain operators want to convey to the tourist and therefore, on the renewal of (geographical) information in ski resorts.

  18. Preliminary Report: Bases for Containment Analysis for Transportation of Aluminum-Based Spent Nuclear Fuel

    International Nuclear Information System (INIS)

    Vinson, D.W.

    1998-01-01

    Aluminum-based spent nuclear fuel (Al-SNF) from foreign and domestic research reactors (FRR/DRR) is being shipped to SRS under the site FRR/DRR Receipts Program. Shipment of the FRR/DRR assemblies required that the cask with loaded fuel be certified by the US Nuclear Regulatory Commission (for US-owned casks) or the US Department of Transportation (for foreign-owned casks) to comply with the requirements in 10CFR71

  19. D3.7 Africa: Conclusion Report

    DEFF Research Database (Denmark)

    Mandrup, Thomas

    2017-01-01

    This report draws together information and analyses from the preceding eight reports of IECEU Work Package 3 that examine the effectiveness of EU civilian crisis management operations in Libya, South Sudan, CAR and DR. Congo. The four cases are examined in separate sections. The following is base...

  20. Preliminary Study on Hybrid Computational Phantom for Radiation Dosimetry Based on Subdivision Surface

    International Nuclear Information System (INIS)

    Jeong, Jong Hwi; Choi, Sang Hyoun; Cho, Sung Koo; Kim, Chan Hyeong

    2007-01-01

    The anthropomorphic computational phantoms are classified into two groups. One group is the stylized phantoms, or MIRD phantoms, which are based on mathematical representations of the anatomical structures. The shapes and positions of the organs and tissues in these phantoms can be adjusted by changing the coefficients of the equations in use. The other group is the voxel phantoms, which are based on tomographic images of a real person such as CT, MR and serially sectioned color slice images from a cadaver. Obviously, the voxel phantoms represent the anatomical structures of a human body much more realistically than the stylized phantoms. A realistic representation of anatomical structure is very important for an accurate calculation of radiation dose in the human body. Consequently, the ICRP recently has decided to use the voxel phantoms for the forthcoming update of the dose conversion coefficients. However, the voxel phantoms also have some limitations: (1) The topology and dimensions of the organs and tissues in a voxel model are extremely difficult to change, and (2) The thin organs, such as oral mucosa and skin, cannot be realistically modeled unless the voxel resolution is prohibitively high. Recently, a new approach has been implemented by several investigators. The investigators converted their voxel phantoms to hybrid computational phantoms based on NURBS (Non-Uniform Rational B-Splines) surface, which is smooth and deformable. It is claimed that these new phantoms have the flexibility of the stylized phantom along with the realistic representations of the anatomical structures. The topology and dimensions of the anatomical structures can be easily changed as necessary. Thin organs can be modeled without affecting computational speed or memory requirement. The hybrid phantoms can be also used for 4-D Monte Carlo simulations. In this preliminary study, the external shape of a voxel phantom (i.e., skin), HDRK-Man, was converted to a hybrid computational

  1. Advanced tokamak reactors based on the spherical torus (ATR/ST). Preliminary design considerations

    International Nuclear Information System (INIS)

    Miller, R.L.; Krakowski, R.A.; Bathke, C.G.; Copenhaver, C.; Schnurr, N.M.; Engelhardt, A.G.; Seed, T.J.; Zubrin, R.M.

    1986-06-01

    Preliminary design results relating to an advanced magnetic fusion reactor concept based on the high-beta, low-aspect-ratio, spherical-torus tokamak are summarized. The concept includes resistive (demountable) toroidal-field coils, magnetic-divertor impurity control, oscillating-field current drive, and a flowing liquid-metal breeding blanket. Results of parametric tradeoff studies, plasma engineering modeling, fusion-power-core mechanical design, neutronics analyses, and blanket thermalhydraulics studies are described. The approach, models, and interim results described here provide a basis for a more detailed design. Key issues quantified for the spherical-torus reactor center on the need for an efficient drive for this high-current (approx.40 MA) device as well as the economic desirability to increase the net electrical power from the nominal 500-MWe(net) value adopted for the baseline system. Although a direct extension of present tokamak scaling, the stablity and transport of this high-beta (approx.0.3) plasma is a key unknown that is resoluble only by experiment. The spherical torus generally provides a route to improved tokamak reactors as measured by considerably simplified coil technology in a configuration that allows a realistic magnetic divertor design, both leading to increased mass power density and reduced cost

  2. A literature-based preliminary characterization of risks in the nuclear waste management system

    International Nuclear Information System (INIS)

    Daling, P.M.; Rhoads, R.E.; Van Luik, A.E.

    1990-04-01

    The objectives of this study were to (1) review the literature containing information on risks in the nuclear waste management system and (2) use this information to develop preliminary estimates of the potential magnitudes of these risks. Information was collected on a broad range of risk categories to assist the US Department of Energy (DOE) in communicating information about the risks in the waste management system. The study, which was completed prior to passage of the Nuclear Waste Policy Amendments Act of 1987, examined all of the portions of the nuclear waste management system envisioned by the DOE in the 1985 ''Mission Plant for the Civilian Radioactive Waste Management Program.'' As such, there may be statements in this paper that are not consistent with current DOE positions. The scope of this paper includes the repository, the integral Monitored Retrievable Storage (MRS) facility, and the transportation system that supports the repository and the MRS facility. Based on the results of this analysis, it is concluded that the radiological risks in the waste management system are small relative to nonradiological risks and relative to the risks of exposure to natural background radiation. 6 refs., 2 figs., 2 tabs

  3. RED WINE EXTRACT OBTAINED BY MEMBRANE-BASED SUPERCRITICAL FLUID EXTRACTION: PRELIMINARY CHARACTERIZATION OF CHEMICAL PROPERTIES.

    Directory of Open Access Journals (Sweden)

    W. Silva

    Full Text Available ABSTRACT This study aims to obtain an extract from red wine by using membrane-based supercritical fluid extraction. This technique involves the use of porous membranes as contactors during the dense gas extraction process from liquid matrices. In this work, a Cabernet Sauvignon wine extract was obtained from supercritical fluid extraction using pressurized carbon dioxide as solvent and a hollow fiber contactor as extraction setup. The process was continuously conducted at pressures between 12 and 18 MPa and temperatures ranged from 30 to 50ºC. Meanwhile, flow rates of feed wine and supercritical CO2 varied from 0.1 to 0.5 mL min-1 and from 60 to 80 mL min-1 (NCPT, respectively. From extraction assays, the highest extraction percentage value obtained from the total amount of phenolic compounds was 14% in only one extraction step at 18MPa and 35ºC. A summarized chemical characterization of the obtained extract is reported in this work; one of the main compounds in this extract could be a low molecular weight organic acid with aromatic structure and methyl and carboxyl groups. Finally, this preliminary characterization of this extract shows a remarkable ORAC value equal to 101737 ± 5324 µmol Trolox equivalents (TE per 100 g of extract.

  4. A preliminary survey of M. hyopneumoniae virulence factors based on comparative genomic analysis

    Directory of Open Access Journals (Sweden)

    Henrique Bunselmeyer Ferreira

    2007-01-01

    Full Text Available Mycoplasma hyopneumoniae is the etiological agent of porcine enzootic pneumonia (PEP, a major problem for the pig industry. The mechanisms of M. hyopneumoniae pathogenicity allow to predict the existence of several classes of virulence factors, whose study has been essentially restricted to the characterization of adhesion-related and major antigenic proteins. The now available complete sequences of the genomes of two pathogenic and one non-pathogenic strain of M. hyopneumoniae allowed to use a comparative genomics approach to putatively identify virulence genes. In this preliminary survey, we were able to identify 118 CDSs encoding putative virulence factors, based on specific criteria ranging from predicted cell surface location or variation between strains to previous functional studies showing antigenicity or involvement in host-pathogen interaction. This survey is expected to serve as a first step towards the functional characterization of new virulence genes/proteins that will be important not only for a better comprehension of M. hyopneumoniae biology, but also for the development of new and improved protocols for PEP vaccination, diagnosis and treatment.

  5. Fusing Panchromatic and SWIR Bands Based on Cnn - a Preliminary Study Over WORLDVIEW-3 Datasets

    Science.gov (United States)

    Guo, M.; Ma, H.; Bao, Y.; Wang, L.

    2018-04-01

    The traditional fusion methods are based on the fact that the spectral ranges of the Panchromatic (PAN) and multispectral bands (MS) are almost overlapping. In this paper, we propose a new pan-sharpening method for the fusion of PAN and SWIR (short-wave infrared) bands, whose spectral coverages are not overlapping. This problem is addressed with a convolutional neural network (CNN), which is trained by WorldView-3 dataset. CNN can learn the complex relationship among bands, and thus alleviate spectral distortion. Consequently, in our network, we use the simple three-layer basic architecture with 16 × 16 kernels to conduct the experiment. Every layer use different receptive field. The first two layers compute 512 feature maps by using the 16 × 16 and 1 × 1 receptive field respectively and the third layer with a 8 × 8 receptive field. The fusion results are optimized by continuous training. As for assessment, four evaluation indexes including Entropy, CC, SAM and UIQI are selected built on subjective visual effect and quantitative evaluation. The preliminary experimental results demonstrate that the fusion algorithms can effectively enhance the spatial information. Unfortunately, the fusion image has spectral distortion, it cannot maintain the spectral information of the SWIR image.

  6. Design and Development of a Linked Open Data-Based Health Information Representation and Visualization System: Potentials and Preliminary Evaluation

    Science.gov (United States)

    Kauppinen, Tomi; Keßler, Carsten; Fritz, Fleur

    2014-01-01

    health information representation, querying, and visualization system by using Linked Data tools. We imported more than 20,000 HIV-related data elements on mortality, prevalence, incidence, and related variables, which are freely available from the WHO global health observatory database. Additionally, we automatically linked 5312 data elements from DBpedia, Bio2RDF, and LinkedCT using the Silk framework. The system users can retrieve and visualize health information according to their interests. For users who are not familiar with SPARQL queries, we integrated a Linked Data search engine interface to search and browse the data. We used the system to represent and store the data, facilitating flexible queries and different kinds of visualizations. The preliminary user evaluation score by public health data managers and users was 82 on the SUS usability measurement scale. The need to write queries in the interface was the main reported difficulty of LOD-based systems to the end user. Conclusions The system introduced in this article shows that current LOD technologies are a promising alternative to represent heterogeneous health data in a flexible and reusable manner so that they can serve intelligent queries, and ultimately support decision-making. However, the development of advanced text-based search engines is necessary to increase its usability especially for nontechnical users. Further research with large datasets is recommended in the future to unfold the potential of Linked Data and Semantic Web for future health information systems development. PMID:25601195

  7. Global Advisory Group: conclusions and recommendations.

    Science.gov (United States)

    1986-02-01

    The conclusions and recommendations formulated for the global program by the 8th meeting of the Expanded Program on Immunization (EPI) Global Advisory Group, which took place during November 1985, are summarized. The Global Advisory Group recommends that, in furtherance of the Five-Point Action Program endorsed by the World Health Assembly in 1983, 3 general and 4 specific actions be taken by national immunization programs with the support of the World Health Organization (WHO) to accelerate EPI progress. These recommendations reflect optimism that the 1990 goal of reducing morbidity and mortality by providing immunization for all children of the world can be realized but also acknowledge that many fundamental problems of national program management remain to be resolved. The general actions are: to promote the achievement of the 1990 immunization goal at national and international levels through collaboration among ministries, organizations, and individuals in both the public and private sectors; to adopt a mix of complementary strategies for program acceleration; and to ensure that rapid increases in coverage can be sustained through mechanisms which strengthen th delivery of other primary health care interventions. The specific actions are as follows: to provide immunization at every contact point; to reduce dropout rates between 1st and last immunizations; to improve immunization services to the disadvantaged in urban areas; and to increase priority for the control of measles, poliomyelitis, and neonatal tetanus. The WHO and the UN International Children's Emergency Fund (UNICEF) have collaborated in support of the EPI since the early days of the program. The acceleration of national efforts heightens the importance of this collaboration, particularly at the national level. It may be further facilitated by the provision of policy guidance from global and regional levels, by WHO and UNICEF collaborative agreements at the regional level, and by country agreements

  8. RELAP5 assessment: conclusions and user guidelines

    International Nuclear Information System (INIS)

    Kmetyk, L.N.

    1984-10-01

    The RELAP5 independent assessment project at Sandia National Laboratories is part of an overall effort funded by the NRC to determine the ability of various systems codes to predict the detailed thermal/hydraulic response of LWRs during accident and off-normal conditions. The RELAP5/MOD1 code has been assessed at Sandia against a variety of test data from both integral and separate effects test facilities. All these analyses have been documented in detail in individual topical reports; in this paper we attempt to evaluate the overall code performance by comparing results from many different calculations, and to offer other users some guidelines based on our experience to date

  9. PRELIMINARY STUDIES FOR PRODUCING CRUDE LIPASE FROM TEMPE’S MOULD CULTIVATED IN RICE-HUSK-BASED SOLID MEDIA

    Directory of Open Access Journals (Sweden)

    Teuku Beuna Bardant

    2010-06-01

    Full Text Available The goal of these preliminary studies is to support Indonesian program for increasing palm oil added value through independent production technology based on Indonesian natural resources. Various palm oil derivatives could be synthesized enzymatically using lipase from microbes that available in Indonesia. Tempe's mould is available in abundance in Indonesia and had already been proved for producing lipase. This paper provides information about producing crude lipase from Tempe's mould cultivated in rice-husk-based solid media using palm oil as carbon source. Observed variables include solid media composition, optimum fermentation time, extraction and enriching process of crude lipase. The crude lipase was analyzed its hydrolysis activity on coconut oil and palm oil. The result of these preliminary studies shows that this production process is a simple and tough process and very potential to be developed.   Keywords: lipase, Tempe's mould, palm oil, solid fermentation, rice husk

  10. Key conclusions from AVOID Work Stream One

    Science.gov (United States)

    Warren, Rachel

    2010-05-01

    AVOID work stream (WS1)one has produced emission scenarios that simulate potential future global emission pathways for greenhouse gases during the 21st century. The study explored the influence of three key features of such pathways: (1) the year in which emissions peak globally, (2) the rate of emission reduction, and (3) the minimum level to which emissions are eventually reduced. It examined the resultant climate change, climate change impacts and economic implications using computer simulations. Avoided impacts, carbon taxes and GDP change increase throughout the 21st century in the models. AVOID-WS1 showed that in the absence of climate policy it is very likely that global mean temperatures would exceed 3 degrees and there are evens chances that the temperature would rise by 4 degrees relative to pre-industrial times. Scenarios that peak emissions in 2016 were more effective at constraining temperatures to below 3 degrees than those that peaked in 2030: one ‘2016' scenario achieved a probability of 45% of avoiding breaching of a 2 degree threshold. Scenarios peaking in 2030 were inconsistent with constraining temperatures to below 2 degrees. Correspondingly, scenarios that peak in 2030 are more effective at avoiding climate impacts than scenarios that peak in 2016, for all sectors that we studied. Hence the date at which emissions peak is more important than the rate of subsequent emissions reduction in determining the avoided impacts. Avoided impacts increase with time, being negligible in the 2030s, significant by the 2050s and large by the 2080s. Finally, the choice of GCM influences the magnitude of the avoided impacts strongly, so that the uncertainties in our estimates of avoided impacts for each scenario are larger than the difference between the scenarios. Our economic analysis is based on models which differ greatly in the assumptions that they make, but generally show that the date at which emissions peak is a stronger driver of induced GDP changes

  11. SciDB versus Spark: A Preliminary Comparison Based on an Earth Science Use Case

    Science.gov (United States)

    Clune, T.; Kuo, K. S.; Doan, K.; Oloso, A.

    2015-12-01

    We compare two Big Data technologies, SciDB and Spark, for performance, usability, and extensibility, when applied to a representative Earth science use case. SciDB is a new-generation parallel distributed database management system (DBMS) based on the array data model that is capable of handling multidimensional arrays efficiently but requires lengthy data ingest prior to analysis, whereas Spark is a fast and general engine for large scale data processing that can immediately process raw data files and thereby avoid the ingest process. Once data have been ingested, SciDB is very efficient in database operations such as subsetting. Spark, on the other hand, provides greater flexibility by supporting a wide variety of high-level tools including DBMS's. For the performance aspect of this preliminary comparison, we configure Spark to operate directly on text or binary data files and thereby limit the need for additional tools. Arguably, a more appropriate comparison would involve exploring other configurations of Spark which exploit supported high-level tools, but that is beyond our current resources. To make the comparison as "fair" as possible, we export the arrays produced by SciDB into text files (or converting them to binary files) for the intake by Spark and thereby avoid any additional file processing penalties. The Earth science use case selected for this comparison is the identification and tracking of snowstorms in the NASA Modern Era Retrospective-analysis for Research and Applications (MERRA) reanalysis data. The identification portion of the use case is to flag all grid cells of the MERRA high-resolution hourly data that satisfies our criteria for snowstorm, whereas the tracking portion connects flagged cells adjacent in time and space to form a snowstorm episode. We will report the results of our comparisons at this presentation.

  12. Overview of human health in the Arctic: conclusions and recommendations.

    Science.gov (United States)

    Donaldson, Shawn; Adlard, Bryan; Odland, Jon Øyvind

    2016-01-01

    This article is intended to provide an overview of the key conclusions, knowledge gaps and key recommendations based on the recent 2015 Arctic human health assessment under the Arctic Monitoring and Assessment Program. This assessment was based primarily on data from human health monitoring and research studies and peer-reviewed literature published since the last assessment in 2009.

  13. PRELIMINARY STUDIES FOR PRODUCING CRUDE LIPASE FROM TEMPE’S MOULD CULTIVATED IN RICE-HUSK-BASED SOLID MEDIA

    OpenAIRE

    Bardant, Teuku Beuna; Sembiring, Kiky Corneliasari; Setiawan, Achmad Hanafi

    2010-01-01

    The goal of these preliminary studies is to support Indonesian program for increasing palm oil added value through independent production technology based on Indonesian natural resources. Various palm oil derivatives could be synthesized enzymatically using lipase from microbes that available in Indonesia. Tempe's mould is available in abundance in Indonesia and had already been proved for producing lipase. This paper provides information about producing crude lipase from Tempe's mould cultiv...

  14. A knowledge-based design framework for airplane conceptual and preliminary design

    Science.gov (United States)

    Anemaat, Wilhelmus A. J.

    The goal of work described herein is to develop the second generation of Advanced Aircraft Analysis (AAA) into an object-oriented structure which can be used in different environments. One such environment is the third generation of AAA with its own user interface, the other environment with the same AAA methods (i.e. the knowledge) is the AAA-AML program. AAA-AML automates the initial airplane design process using current AAA methods in combination with AMRaven methodologies for dependency tracking and knowledge management, using the TechnoSoft Adaptive Modeling Language (AML). This will lead to the following benefits: (1) Reduced design time: computer aided design methods can reduce design and development time and replace tedious hand calculations. (2) Better product through improved design: more alternative designs can be evaluated in the same time span, which can lead to improved quality. (3) Reduced design cost: due to less training and less calculation errors substantial savings in design time and related cost can be obtained. (4) Improved Efficiency: the design engineer can avoid technically correct but irrelevant calculations on incomplete or out of sync information, particularly if the process enables robust geometry earlier. Although numerous advancements in knowledge based design have been developed for detailed design, currently no such integrated knowledge based conceptual and preliminary airplane design system exists. The third generation AAA methods are tested over a ten year period on many different airplane designs. Using AAA methods will demonstrate significant time savings. The AAA-AML system will be exercised and tested using 27 existing airplanes ranging from single engine propeller, business jets, airliners, UAV's to fighters. Data for the varied sizing methods will be compared with AAA results, to validate these methods. One new design, a Light Sport Aircraft (LSA), will be developed as an exercise to use the tool for designing a new airplane

  15. Preliminary training of a self-pumped loop phase-conjugate mirror based on a photorefractive crystal

    International Nuclear Information System (INIS)

    Mogaddam, Mehran Wahdani; Shuvalov, Vladimir V

    2006-01-01

    It is shown by the example of a loop self-pumped phase-conjugate (SPPC) mirror based on a photorefractive crystal (PRC) BaTiO 3 that formation of a phase-conjugate (PC) wave in a SPPC mirror can be considerably accelerated by using a preliminary training of the mirror. For this purpose, it is necessary to direct preliminary an auxiliary (training) optical field on the SPPC mirror, which contains some information on the properties of the input signal whose wave front will be conjugated later. This procedure provides the writing of static refractive-index gratings in the PRC already at the training stage. The presence of these gratings ensures a much more rapid (by 6-20 times) production of volume refractive-index gratings required for the efficient conjugation of the signal radiation. Several variants of static and dynamic SPPC mirror training procedures are simulated and their efficiencies are compared. (nonlinear optical phenomena)

  16. Assessment of electromagnetic fields intensity emitted by cellular phone base stations in surrounding flats - a preliminary study

    International Nuclear Information System (INIS)

    Zmyslony, M.; Politanski, P.; Mamrot, P.; Bortkiewicz, A.

    2006-01-01

    A rapid development of mobile telecommunications (MT) has resulted in an increased concern about possible detrimental health effects of electromagnetic fields (EMFs) emitted by MT systems, and by MT base stations in particular. Research into EMFs effects on the health of inhabitants living in their vicinity requires first of all a solid assessment of the exposure level. Up to now, the reports in this field have been rather scant. This article presents the results of preliminary measurements of EMFs fields in selected flats around selected base stations in the city of Lodz. Measurements of electric field strength, E, to assess EMF exposure were based on the standard procedures currently in force in Poland. As the study is regarded as a preliminary one, the measurements were conducted in buildings with the expected largest radiation. The measurements show that in the flats located up to 500 m from the base station, EMFs are within the limits specified by relevant Polish regulations on the general public and environmental protection. It was also observed that in a few (less than 10%) flats the field with E exceeded 0.8 V/m. The results show that there are no correlations between electric field strength and distance between the flat and the base station. Therefore, the distance from the base station cannot be used to represent the exposure rate; to determine the latter, EMF measurements are necessary. (author)

  17. Preliminary evaluation of a virtual reality-based simulator for learning spinal anesthesia.

    LENUS (Irish Health Repository)

    2012-12-27

    STUDY OBJECTIVE: To evaluate the influence of a simulation-based program on the initial performance of dural puncture by medical interns, and to refine the design of simulator-based teaching and competence assessment. DESIGN: Prospective interventional study. SETTING: Academic medical center. SUBJECTS: 27 medical interns inexperienced in the technique of spinal anesthesia or dural puncture and within 12 months of graduating from medical school, were randomly assigned to a conventional or a simulator-based teaching course of spinal anesthesia: 13 were recruited to the Conventional Group (CG) and 14 to the Simulator Group (SG). MEASUREMENTS: A SenseGraphic Immersive workbench and a modified Phantom desktop with shutter glasses were used to create a teaching environment. Outcomes of teaching were assessed in two phases within three weeks of the teaching course: Phase I consisted of a written examination followed by assessment on the simulator. A global rating scale and a task-specific checklist were used. Phase II (for those participants for whom a suitable opportunity arose to perform spinal anesthesia under supervision within three wks of the teaching course) consisted of structured observation of clinical performance of the procedure in the operating room. Participants were assessed by independent, study-blinded experts. Student\\'s two-tailed impaired t-tests were used to compare the parametric outcomes (P < 0.05 was considered significant). MAIN RESULTS: All participants completed the written test successfully with no difference between groups. Ten participants from CG and 13 from SG completed the simulator-based testing performing similarly in terms of the global rating scale. Five participants in CG and 6 in SG proceeded to clinical testing. On the global rating scale, interns in SG scored higher than those in CG. They performed similarly according to the task-specific checklist. CONCLUSIONS: Overall, no difference was measured between those taught with

  18. A Preliminary Study on the Efficacy of a Community-Based Physical Activity Intervention on Physical Function-Related Risk Factors for Falls among Breast Cancer Survivors

    Science.gov (United States)

    Lee, C. Ellen; Warden, Stuart J.; Szuck, Beth; Lau, Y.K. James

    2015-01-01

    Objective The aim of this study was to examine the effects of a 6-week community-based physical activity (PA) intervention on physical function-related risk factors for falls among 56 breast cancer survivors (BCS) who had completed treatments. Design This was a single-group longitudinal study. The multimodal PA intervention included aerobic, strengthening and balance components. Physical function outcomes based on the 4-meter walk, chair stand, one-leg stance, tandem walk, and dynamic muscular endurance tests were assessed at 6-week pre-intervention (T1), baseline (T2), and post-intervention (T3). T1-T2 and T2-T3 were the control and intervention periods, respectively. Results All outcomes, except the tandem walk test, significantly improved after the intervention period (p 0.05). Based on the falls risk criterion in the one-leg stance test, the proportion at risk for falls was significantly lower after the intervention period (p = 0.04), but not after the control period. Conclusions A community-based multimodal PA intervention for BCS may be efficacious in improving physical function-related risk factors for falls, and lowering the proportion of BCS at risk for falls based on specific physical function-related falls criteria. Further larger trials are needed to confirm these preliminary findings. PMID:26829081

  19. Target tracking system based on preliminary and precise two-stage compound cameras

    Science.gov (United States)

    Shen, Yiyan; Hu, Ruolan; She, Jun; Luo, Yiming; Zhou, Jie

    2018-02-01

    Early detection of goals and high-precision of target tracking is two important performance indicators which need to be balanced in actual target search tracking system. This paper proposed a target tracking system with preliminary and precise two - stage compound. This system using a large field of view to achieve the target search. After the target was searched and confirmed, switch into a small field of view for two field of view target tracking. In this system, an appropriate filed switching strategy is the key to achieve tracking. At the same time, two groups PID parameters are add into the system to reduce tracking error. This combination way with preliminary and precise two-stage compound can extend the scope of the target and improve the target tracking accuracy and this method has practical value.

  20. A preliminary study on the dielectric constant of WPC based on some tropical woods

    International Nuclear Information System (INIS)

    Chia, L.H.L.; Chua, P.H.; Hon, Y.S.; Lee, E.

    1986-01-01

    The use of WPC as an important insulating material is studied by determining its dielectric constant. The variation of dielectric constant with moisture content is also investigated. Preliminary results show that all untreated woods studied have a higher dielectric constant than their polymer composites with the exception of Kapur and Keruing. It is therefore postulated that the presence of polymers has led to a decrease in the number of polarizable units. Such a material may be useful commercially. (author)

  1. Attitudes and awareness of web-based self-care resources in the military: a preliminary survey study.

    Science.gov (United States)

    Luxton, David D; Armstrong, Christina M; Fantelli, Emily E; Thomas, Elissa K

    2011-09-01

    Web-based self-care resources have a number of potential benefits for military service members (SMs) and their families such as convenience, anonymity, and immediate 24/7 access to useful information. There is limited data available, however, regarding SM and military healthcare provider use of online self-care resources. Our goal with this study was to conduct a preliminary survey assessment of self-care Web site awareness, general attitudes about use, and usage behaviors of Web-based self-care resources among SMs and military healthcare providers. Results show that the majority of SMs and providers use the Internet often, use Internet self-care resources, and are willing to use additional Web-based resources and capabilities. SMs and providers also indicated a preference for Web-based self-care resources as adjunct tools to face-to-face/in-person care. Data from this preliminary study are useful for informing additional research and best practices for integrating Web-based self-care for the military community.

  2. Preliminary Conclusions after the Design and Implementation of Mobile Learning Apps for Professionals

    Science.gov (United States)

    Castrillo, María Dolores; Bárcena, Elena; Pareja-Lora, Antonio

    2014-01-01

    According to a recent research carried out by Aruba Networks (2014) in the US, the UK, France, Spain, Germany, Sweden, South Africa, Saudi Arabia and UAE, 86% of all respondents have two or more devices that can connect to the internet, and nearly two thirds (64%) already own three or more mobile devices with this feature; another 39% own four or…

  3. A preliminary investigation of the initiation of pitting corrosion in austenitic stainless steels and nickel-based alloys

    International Nuclear Information System (INIS)

    Higginson, A.

    1984-01-01

    Pitting corrosion in a number of austenitic stainless steels and nickel-based alloys that differ widely in their resistance to corrosion was studed by electrochemical and electron-optical techniques. The effect of contamination of the sulphuric acid electrolyte by chloride ions was also investigated. Preliminary results for the surface analysis of samples of 316 stainless steel by Auger electron spectroscopy are presented, and suggestions are included for further application of this technique to the examination of pitting corrosion. A comprehensive review of the literature concerning the initiation of pitting corrosion is included

  4. Thorium-Based Fuels Preliminary Lattice Cell Studies for Candu Reactors

    International Nuclear Information System (INIS)

    Margeanu, C.A.; Rizoiu, A.C.

    2009-01-01

    The choice of nuclear power as a major contributor to the future global energy needs must take into account acceptable risks of nuclear weapon proliferation, in addition to economic competitiveness, acceptable safety standards, and acceptable waste disposal options. Candu reactors offer a proven technology, safe and reliable reactor technology, with an interesting evolutionary potential for proliferation resistance, their versatility for various fuel cycles creating premises for a better utilization of global fuel resources. Candu reactors impressive degree of fuel cycle flexibility is a consequence of its channel design, excellent neutron economy, on-power refueling, and simple fuel bundle. These features facilitate the introduction and exploitation of various fuel cycles in Candu reactors in an evolutionary fashion. The main reasons for our interest in Thorium-based fuel cycles have been, globally, to extend the energy obtainable from natural Uranium and, locally, to provide a greater degree of energy self-reliance. Applying the once through Thorium (OTT) cycle in existing and advanced Candu reactors might be seen as an evaluative concept for the sustainable development both from the economic and waste management points of view. Two Candu fuel bundles project will be used for the proposed analysis, namely the Candu standard fuel bundle with 37 fuel elements and the CANFLEX fuel bundle with 43 fuel elements. Using the Canadian proposed scheme - loading mixed ThO 2 -SEU CANFLEX bundles in Candu 6 reactors - simulated at lattice cell level led to promising conclusions on operation at higher fuel burnups, reduction of the fissile content to the end of the cycle, minor actinide content reduction in the spent fuel, reduction of the spent fuel radiotoxicity, presence of radionuclides emitting strong gamma radiation for proliferation resistance benefit. The calculations were performed using the lattice codes WIMS and Dragon (together with the corresponding nuclear data

  5. Preliminary Cost Model for Space Telescopes

    Science.gov (United States)

    Stahl, H. Philip; Prince, F. Andrew; Smart, Christian; Stephens, Kyle; Henrichs, Todd

    2009-01-01

    Parametric cost models are routinely used to plan missions, compare concepts and justify technology investments. However, great care is required. Some space telescope cost models, such as those based only on mass, lack sufficient detail to support such analysis and may lead to inaccurate conclusions. Similarly, using ground based telescope models which include the dome cost will also lead to inaccurate conclusions. This paper reviews current and historical models. Then, based on data from 22 different NASA space telescopes, this paper tests those models and presents preliminary analysis of single and multi-variable space telescope cost models.

  6. Framework for Human-Automation Collaboration: Conclusions from Four Studies

    Energy Technology Data Exchange (ETDEWEB)

    Oxstrand, Johanna [Idaho National Lab. (INL), Idaho Falls, ID (United States); Le Blanc, Katya L. [Idaho National Lab. (INL), Idaho Falls, ID (United States); O' Hara, John [Brookhaven National Lab. (BNL), Upton, NY (United States); Joe, Jeffrey C. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Whaley, April M. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Medema, Heather [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2013-11-01

    The Human Automation Collaboration (HAC) research project is investigating how advanced technologies that are planned for Advanced Small Modular Reactors (AdvSMR) will affect the performance and the reliability of the plant from a human factors and human performance perspective. The HAC research effort investigates the consequences of allocating functions between the operators and automated systems. More specifically, the research team is addressing how to best design the collaboration between the operators and the automated systems in a manner that has the greatest positive impact on overall plant performance and reliability. Oxstrand et al. (2013 - March) describes the efforts conducted by the researchers to identify the research needs for HAC. The research team reviewed the literature on HAC, developed a model of HAC, and identified gaps in the existing knowledge of human-automation collaboration. As described in Oxstrand et al. (2013 – June), the team then prioritized the research topics identified based on the specific needs in the context of AdvSMR. The prioritization was based on two sources of input: 1) The preliminary functions and tasks, and 2) The model of HAC. As a result, three analytical studies were planned and conduced; 1) Models of Teamwork, 2) Standardized HAC Performance Measurement Battery, and 3) Initiators and Triggering Conditions for Adaptive Automation. Additionally, one field study was also conducted at Idaho Falls Power.

  7. El prestigi empresarial: Anàlisi a través de les conselleries creuades The business prestige: A preliminary study based on interlocks within companies The business prestige: A preliminary study based on interlocks within companies

    Directory of Open Access Journals (Sweden)

    David Gonzalez-Prieto

    2011-11-01

    Full Text Available Purpose: The literature on interlocked directorate or interlocks has proposed the presence of cross-directors as an influential factor in the prestige of a firm (Mizruchi, 1996. This theory is based on the fact that, by having multiple companies with interlocks within them, major stakeholders of the company ought to have a higher perception of prestige. The aim of this preliminary study is to present an exploratory study and suggest future research lines on this issue. Design/methodology/approach: In a first preliminary study, we evaluate the interlocks network comprising companies belonging to the ranking established by the MERCO report in Spain for the year 2010. This is a well-known ranking of corporate reputation in Spain used in recent articles (Luna & Fernandez, 2010. For further analysis, other variables are considered as being quoted in the Spanish market benchmark index, IBEX 35, and the location of the headquarters.Findings: Significant positive relationship was obtained between the number of directorships shared with other public companies and the perceived prestige that stakeholders perceive from the firm. Similarly, we obtain significant positive correlation between the prestige and being listed on the IBEX 35. Finally, we identified banking, construction and energy sectors as the ones that use interlocking directorates more intensively.Research limitations: The results of this preliminary study show the viability of future studies about prestige and interlocks (Mizruchi, 1996. For the validation of the theory described in this study, it should be replicated in different regions and, with larger samples, to observe the effect that interlocks have on the perception of prestige of the company.Practical implications / Originality/value: This is among the first studies showing the existence of a relationship between interlocks and business prestige. It highlights the importance of the composition of the boards for the perceived prestige

  8. Preliminary characterization of risks in the nuclear waste management system based on information in the literature

    International Nuclear Information System (INIS)

    Daling, P.M.; Rhoads, R.E.; Van Luick, A.E.; Fecht, B.A.; Nilson, S.A.; Sevigny, N.L.; Armstrong, G.R.; Hill, D.H.; Rowe, M.; Stern, E.

    1992-01-01

    This document presents preliminary information on the radiological and nonradiological risks in the nuclear waste management system. The objective of the study was to (1) review the literature containing information on risks in the nuclear waste management system and (2) use this information to develop preliminary estimates of the potential magnitude of these risks. Information was collected on a broad range of risk categories to assist the US Department of Energy (DOE) in communicating information about the risks in the waste management systems. The study examined all of the portions of the nuclear waste management system currently expected to be developed by the DOE. The scope of this document includes the potential repository, the integral MRS facility, and the transportation system that supports the potential repository and the MRS facility. Relevant literature was reviewed for several potential repository sites and geologic media. A wide range of ''risk categories'' are addressed in this report: (1) public and occupational risks from accidents that could release radiological materials, (2) public and occupational radiation exposure resulting from routine operations, (3) public and occupational risks from accidents involving hazards other than radioactive materials, and (4) public and occupational risks from exposure to nonradioactive hazardous materials during routine operations. The report is intended to provide a broad spectrum of risk-related information about the waste management system. This information is intended to be helpful for planning future studies

  9. Preliminary safety evaluation for the Simpevarp subarea. Based on data and site descriptions after the initial site investigation stage

    International Nuclear Information System (INIS)

    2005-04-01

    elucidate the importance of these uncertainties. The migration properties of the rock matrix (porosity, formation factor and K d ) meet the preferred values. However, the values are based on few samples only and evaluation of more samples would thus enhance this conclusion. The assessments made for the PSE also suggest some implications for design, some of which are of a generic character to be considered also for the other sites. The most important such feedbacks are: Compared to the actual safety requirement, the design rules for discarding canister positions due to potential intersection with too large fractures or deformation zones are overly restrictive. The percentage of deposition holes to be discarded would substantially decrease if the design rules were better harmonised with the actual safety requirements. However, it is important to note that current design rules overestimate the number of discarded deposition holes. The spatial variability of the thermal conductivity may be too large to be consistent with the currently adopted design rules, which only consider mean values and a margin to handle spatial variability. The additional temperature analyses conducted here and the predicted spatial variability of thermal conductivity imply that the canister spacing currently suggested by design may be insufficient at some canister locations. The temperature margin for the gaps between canister/buffer and buffer/rock and for the uncertainty/variability in rock thermal conductivity applied in the design work should be revisited, since the present rules seem to leave too little margin for these factors. Finally, this PSE also highlights issues that would have to be considered if the Simpevarp subarea was to be assessed in a full safety assessment. Most of the issues are rather generic in nature and thus also warrant consideration in future safety assessments of other sites

  10. Photocatalytic hydrogen production under direct solar light in a CPC based solar reactor: Reactor design and preliminary results

    International Nuclear Information System (INIS)

    Jing Dengwei; Liu Huan; Zhang Xianghui; Zhao Liang; Guo Liejin

    2009-01-01

    In despite of so many types of solar reactors designed for solar detoxification purposes, few attempts have been made for photocatalytic hydrogen production, which in our option, is one of the most promising approaches for solar to chemical energy conversion. Addressing both the similarity and dissimilarity for these two processes and by fully considering the special requirements for the latter reaction, a Compound Parabolic Concentrator (CPC) based photocatalytic hydrogen production solar reactor has been designed for the first time. The design and optimization of this CPC based solar reactor has been discussed in detail. Preliminary results demonstrated that efficient photocatalytic hydrogen production under direct solar light can be accomplished by coupling tubular reactors with CPC concentrators. It is anticipated that this first demonstration of concentrator-based solar photocatalytic hydrogen production would draw attention for further studies in this promising direction.

  11. Methodology and a preliminary data base for examining the health risks of electricity generation from uranium and coal fuels

    Energy Technology Data Exchange (ETDEWEB)

    El-Bassioni, A.A.

    1980-08-01

    An analytical model was developed to assess and examine the health effects associated with the production of electricity from uranium and coal fuels. The model is based on a systematic methodology that is both simple and easy to check, and provides details about the various components of health risk. A preliminary set of data that is needed to calculate the health risks was gathered, normalized to the model facilities, and presented in a concise manner. Additional data will become available as a result of other evaluations of both fuel cycles, and they should be included in the data base. An iterative approach involving only a few steps is recommended for validating the model. After each validation step, the model is improved in the areas where new information or increased interest justifies such upgrading. Sensitivity analysis is proposed as the best method of using the model to its full potential. Detailed quantification of the risks associated with the two fuel cycles is not presented in this report. The evaluation of risks from producing electricity by these two methods can be completed only after several steps that address difficult social and technical questions. Preliminary quantitative assessment showed that several factors not considered in detail in previous studies are potentially important. 255 refs., 21 figs., 179 tabs.

  12. Feasibility and preliminary efficacy of a web-based parenting skills program for young children with traumatic brain injury.

    Science.gov (United States)

    Wade, Shari L; Oberjohn, Karen; Burkhardt, Abby; Greenberg, Ira

    2009-01-01

    To report the feasibility and preliminary efficacy of a Web-based parenting skills program to reduce behavior problems following traumatic brain injury (TBI) in young children. Families of 9 children between the ages of 3 and 8 years with TBI, injured less than 24 months earlier, participated in a pilot study of a Web-based parenting skills program designed to increase positive parenting skills and to improve caregiver stress management and coping. The program consisted of 10 core sessions and up to 4 supplemental sessions. Each session consisted of self-guided didactic information, video modeling skills, and exercises. Online sessions were followed by synchronous sessions providing in vivo coaching of target skills. Caregivers completed an average of 12 sessions (range 5-24). Ratings of ease of use and satisfaction were high. Paired t tests revealed significant improvements in target parenting behaviors between baseline and session 2 and between sessions 2 and 4. These improvements were maintained at follow-up. Among the 5 families who completed the follow-up assessment, there were trends for reductions in the overall number of behavior problems. This study provides preliminary evidence of the potential feasibility and efficacy of an online parenting skills intervention for improving positive parenting skills and for reducing child behavior problems following early TBI.

  13. Preliminary investigation of novel bone graft substitutes based on strontium-calcium-zinc-silicate glasses.

    Science.gov (United States)

    Boyd, D; Carroll, G; Towler, M R; Freeman, C; Farthing, P; Brook, I M

    2009-01-01

    Bone graft procedures typically require surgeons to harvest bone from a second site on a given patient (Autograft) before repairing a bone defect. However, this results in increased surgical time, excessive blood loss and a significant increase in pain. In this context a synthetic bone graft with excellent histocompatibility, built in antibacterial efficacy and the ability to regenerate healthy tissue in place of diseased tissue would be a significant step forward relative to current state of the art philosophies. We developed a range of calcium-strontium-zinc-silicate glass based bone grafts and characterised their structure and physical properties, then evaluated their in vitro cytotoxicity and in vivo biocompatibility using standardised models from the literature. A graft (designated BT109) of composition 0.28SrO/0.32ZnO/0.40 SiO(2) (mol fraction) was the best performing formulation in vitro shown to induce extremely mild cytopathic effects (cell viability up to 95%) in comparison with the commercially available bone graft Novabone (cell viability of up to 72%). Supplementary to this, the grafts were examined using the standard rat femur healing model on healthy Wister rats. All grafts were shown to be equally well tolerated in bone tissue and new bone was seen in close apposition to implanted particles with no evidence of an inflammatory response within bone. Complimentary to this BT109 was implanted into the femurs of ovariectomized rats to monitor the response of osteoporotic tissue to the bone grafts. The results from this experiment indicate that the novel grafts perform equally well in osteoporotic tissue as in healthy tissue, which is encouraging given that bone response to implants is usually diminished in ovariectomized rats. In conclusion these materials exhibit significant potential as synthetic bone grafts to warrant further investigation and optimisation.

  14. Poster - 08: Preliminary Investigation into Collapsed-Cone based Dose Calculations for COMS Eye Plaques

    International Nuclear Information System (INIS)

    Morrison, Hali; Menon, Geetha; Sloboda, Ron

    2016-01-01

    Purpose: To investigate the accuracy of model-based dose calculations using a collapsed-cone algorithm for COMS eye plaques loaded with I-125 seeds. Methods: The Nucletron SelectSeed 130.002 I-125 seed and the 12 mm COMS eye plaque were incorporated into a research version of the Oncentra® Brachy v4.5 treatment planning system which uses the Advanced Collapsed-cone Engine (ACE) algorithm. Comparisons of TG-43 and high-accuracy ACE doses were performed for a single seed in a 30×30×30 cm 3 water box, as well as with one seed in the central slot of the 12 mm COMS eye plaque. The doses along the plaque central axis (CAX) were used to calculate the carrier correction factor, T(r), and were compared to tabulated and MCNP6 simulated doses for both the SelectSeed and IsoAid IAI-125A seeds. Results: The ACE calculated dose for the single seed in water was on average within 0.62 ± 2.2% of the TG-43 dose, with the largest differences occurring near the end-welds. The ratio of ACE to TG-43 calculated doses along the CAX (T(r)) of the 12 mm COMS plaque for the SelectSeed was on average within 3.0% of previously tabulated data, and within 2.9% of the MCNP6 simulated values. The IsoAid and SelectSeed T(r) values agreed within 0.3%. Conclusions: Initial comparisons show good agreement between ACE and MC doses for a single seed in a 12 mm COMS eye plaque; more complicated scenarios are being investigated to determine the accuracy of this calculation method.

  15. Poster - 08: Preliminary Investigation into Collapsed-Cone based Dose Calculations for COMS Eye Plaques

    Energy Technology Data Exchange (ETDEWEB)

    Morrison, Hali; Menon, Geetha; Sloboda, Ron [Cross Cancer Institute, Edmonton, AB, and University of Alberta, Edmonton, AB, Cross Cancer Institute, Edmonton, AB, and University of Alberta, Edmonton, AB, Cross Cancer Institute, Edmonton, AB, and University of Alberta, Edmonton, AB (Canada)

    2016-08-15

    Purpose: To investigate the accuracy of model-based dose calculations using a collapsed-cone algorithm for COMS eye plaques loaded with I-125 seeds. Methods: The Nucletron SelectSeed 130.002 I-125 seed and the 12 mm COMS eye plaque were incorporated into a research version of the Oncentra® Brachy v4.5 treatment planning system which uses the Advanced Collapsed-cone Engine (ACE) algorithm. Comparisons of TG-43 and high-accuracy ACE doses were performed for a single seed in a 30×30×30 cm{sup 3} water box, as well as with one seed in the central slot of the 12 mm COMS eye plaque. The doses along the plaque central axis (CAX) were used to calculate the carrier correction factor, T(r), and were compared to tabulated and MCNP6 simulated doses for both the SelectSeed and IsoAid IAI-125A seeds. Results: The ACE calculated dose for the single seed in water was on average within 0.62 ± 2.2% of the TG-43 dose, with the largest differences occurring near the end-welds. The ratio of ACE to TG-43 calculated doses along the CAX (T(r)) of the 12 mm COMS plaque for the SelectSeed was on average within 3.0% of previously tabulated data, and within 2.9% of the MCNP6 simulated values. The IsoAid and SelectSeed T(r) values agreed within 0.3%. Conclusions: Initial comparisons show good agreement between ACE and MC doses for a single seed in a 12 mm COMS eye plaque; more complicated scenarios are being investigated to determine the accuracy of this calculation method.

  16. CT-based virtual tracheobronchoscopy in children - comparison with axial CT and multiplanar reconstruction: preliminary results

    International Nuclear Information System (INIS)

    Sorantin, Erich; Lindbichler, Franz; Eber, Ernst; Schimpl, Guenther

    2002-01-01

    Background: 3D post-processing of spiral-CT (S-CT) data using perspective projection allows the generation of virtual views similar to endoscopy. Objective: To evaluate whether simultaneous reading of axial S-CT, multiplanar reconstruction (MPR) and virtual tracheobronchoscopy (VTB) is more precise and accurate than reading of axial S-CT and MPR alone in paediatric patients. Materials and methods: S-CT studies of 15 symptomatic and 4 normal patients were investigated. Two radiologists independently read two sets of images for airway abnormalities: first axial CT and MPR, followed by axial CT, MPR and VTB. A final decision was later made by consensus. All results were compared to fibre-optic bronchoscopy (FTB). Interobserver agreement was used as an indicator of precision for the display technique used. Results: At reading of axial S-CT and MPR an interobserver agreement of 89.5% (κ=0.776, P<0.00103) was found. Based on the consensus decision, a diagnostic accuracy of 89.5% at a sensitivity 86.6% and specificity of 100% (κ=0.776, 95% CI 0.491-1.062, P<0.00103) was achieved. At reporting on axial S-CT, MPR and VTB, all cases were classified correctly by both readers, indicating 100% accuracy, interobserver agreement, sensitivity and specificity (κ=1.00, 95% CI 1.0-1.0, P<0.000258). Conclusions: The simultaneous display of axial S-CT, MPR and VTB raises the precision, accuracy and sensitivity of radiological reports. (orig.)

  17. Preliminary application of voxel-based morphometry technique on brain changes in neuromyelitis

    International Nuclear Information System (INIS)

    Xiao Hui; Ma Lin; Chen Ziqian; Lou Xin; Chen Zhiye

    2011-01-01

    Objective: To investigate the changes of brain volumes in neuromyelitis optica (NMO) patients using voxel-based morphometry (VBM) method, and preliminarily explore the pattern of cerebral anatomical impairment. Methods: Twenty-three clinically defined NMO patients and 15 gender and age matched healthy volunteers underwent 3-dimensional (3D) fast spoiled gradient echo (FSPGR) sequence scanning on 3.0 Tesla MR system. Raw data was processed and analyzed using statistical parametric mapping (SPM) 5. Whole brain volumes included grey matter volume (GMV), white matter volume (WMV), total intracranial volume (TIV), grey matter fraction (GMF), white matter fraction (WMF), brain tissue fraction (BTF) and regional brain volumes between the two groups were compared by independent samples t-test and an Pearson were performed to compare the regional brain volumes and the ages. Results: GMV of NMO group [(610.2±55.0) ml] was significantly decreased comparing to healthy control group [(657.2±36.3) ml] (t=-2.915, P<0.05). The age of NMO patients [(40±9) years old] showed negative correlation with GMF [(42.5±2.6) %] (r=-0.673, P<0.05). Regional brain volume analysis showed decreased GMV in left insula and bilateral posterior cingutates in NMO patients, while decreased WMV was found in left frontal and left parietal white matter. Conclusion: VBM could detect brain volume changes sensitively. Total grey matter volume in NMO patients was decreased comparing to HC group. Regional grey matter atrophy in NMO patients occurred in left insular and bilateral posterior cingutates, regional white matter atrophy occurred in left frontal and left parietal lobe. (authors)

  18. Waste dislodging and conveyance testing summary and conclusions to date

    International Nuclear Information System (INIS)

    Rinker, M.W.; Hatchell, B.K.; Mullen, O.D.

    1994-09-01

    This document summarizes recent work performed by the Waste Dislodging and Conveyance technology development program to provide assistance with the retrieval of wastes from the Hanford single-shell tanks (SSTs). This work is sponsored by the Underground Storage Tank-Integrated Demonstration (UST-ID) Office with the U.S. Department of Energy (DOE) Office of Technology Development. A baseline technology of high-pressure water-jet dislodging and pneumatic conveyance integrated as a scarifier is proposed as a means of retrieval. The tests and studies described were performed to demonstrate that at least one robust technology exists that could be effectively used with low water-addition arm-based systems. These results are preliminary and do not represent an optimized baseline. The Waste Dislodging and Conveyance work thus far has demonstrated that waterjet mobilization and air conveyance can mobilize and convey SST waste simulants at the target rates while operating within the space envelope and the dynamic loading constraints of deployment devices. The recommended technologies are well proven in industrial applications and are quite robust, yet lightweight and relatively benign to the retrieval environment. The baseline approach has versatility to continuously dislodge and convey a broad range of waste forms, from hard wastes to soft sludge wastes. The approach also has the major advantage of being noncontact with the waste surface under normal operation

  19. Preliminary study for the personal handheld device based snoring detection in ordinary sleep situation.

    Science.gov (United States)

    Shin, Hangsik; Choi, Wangrim; Kim, Yi-gon; Cho, Jaegeol

    2014-01-01

    Snoring is one of the representative phenomena of the sleep disorder and detection of snoring is quite important for improving quality of daily human life. The purpose of this research is to define the noises of the ordinary sleep situation and to find its characteristics as a preliminary research of snoring detection. Differently from previous snoring researches, we use a built-in sound recording system of Smartphone for practical use in ordinary sleep condition, and recording was carried out in a general private bedroom. Especially, we designed the experimental protocol, including the various noises could be frequently occurred during sleep such as cough, music, talking, alarm, door open/close, fan, radio and footstep to make closer to the actual sleep circumstance. The sound data set was recorded during actual sleep from 10 normal subjects. Totally 44 snoring data set and 75-noise dataset is acquired and analyzed.

  20. A novel attention training paradigm based on operant conditioning of eye gaze: Preliminary findings.

    Science.gov (United States)

    Price, Rebecca B; Greven, Inez M; Siegle, Greg J; Koster, Ernst H W; De Raedt, Rudi

    2016-02-01

    Inability to engage with positive stimuli is a widespread problem associated with negative mood states across many conditions, from low self-esteem to anhedonic depression. Though attention retraining procedures have shown promise as interventions in some clinical populations, novel procedures may be necessary to reliably attenuate chronic negative mood in refractory clinical populations (e.g., clinical depression) through, for example, more active, adaptive learning processes. In addition, a focus on individual difference variables predicting intervention outcome may improve the ability to provide such targeted interventions efficiently. To provide preliminary proof-of-principle, we tested a novel paradigm using operant conditioning to train eye gaze patterns toward happy faces. Thirty-two healthy undergraduates were randomized to receive operant conditioning of eye gaze toward happy faces (train-happy) or neutral faces (train-neutral). At the group level, the train-happy condition attenuated sad mood increases following a stressful task, in comparison to train-neutral. In individual differences analysis, greater physiological reactivity (pupil dilation) in response to happy faces (during an emotional face-search task at baseline) predicted decreased mood reactivity after stress. These Preliminary results suggest that operant conditioning of eye gaze toward happy faces buffers against stress-induced effects on mood, particularly in individuals who show sufficient baseline neural engagement with happy faces. Eye gaze patterns to emotional face arrays may have a causal relationship with mood reactivity. Personalized medicine research in depression may benefit from novel cognitive training paradigms that shape eye gaze patterns through feedback. Baseline neural function (pupil dilation) may be a key mechanism, aiding in iterative refinement of this approach. (c) 2016 APA, all rights reserved).

  1. Review conclusions by Ernst and Canter regarding spinal manipulation refuted

    Directory of Open Access Journals (Sweden)

    Evans Roni

    2006-08-01

    Full Text Available Abstract In the April 2006 issue of the Journal of Royal Society of Medicine, Ernst and Canter authored a review of the most recent systematic reviews on the effectiveness of spinal manipulation for any condition. The authors concluded that, except for back pain, spinal manipulation is not an effective intervention for any condition and, because of potential side effects, cannot be recommended for use at all in clinical practice. Based on a critical appraisal of their review, the authors of this commentary seriously challenge the conclusions by Ernst and Canter, who did not adhere to standard systematic review methodology, thus threatening the validity of their conclusions. There was no systematic assessment of the literature pertaining to the hazards of manipulation, including comparison to other therapies. Hence, their claim that the risks of manipulation outweigh the benefits, and thus spinal manipulation cannot be recommended as treatment for any condition, was not supported by the data analyzed. Their conclusions are misleading and not based on evidence that allow discrediting of a large body of professionals using spinal manipulation.

  2. Selection of Sperm Based on Hypo-Osmotic Swelling May Improve ICSI Outcome: A Preliminary Prospective Clinical Trial

    Directory of Open Access Journals (Sweden)

    Nasim Charehjooy

    2014-03-01

    Full Text Available Background: The intra-cytoplasmic sperm injection (ICSI technique selects sperm according to morphology and motility. However, these parameters cannot predict the chromatin integrity of sperm. Considering the detrimental effects of DNA-damaged sperm on reproductive outcomes, novel sperm selection procedures have been proposed to circumvent the possibility of inseminating DNA-damaged sperm. It has been shown that different potential hypo-osmotic swelling test (HOST patterns possess the potential to differentiate between sperm that have intact or damaged chromatin. Therefore, for the first time, this preliminary study evaluates the role of HOST as a sperm selection procedure in a clinical setting. Materials and Methods: In this preliminary prospective clinical trial study, we divided infertile couples diagnosed with male infertility into two groups. In the treatment group (n=39, half of the oocytes were inseminated by sperm selected following density gradient centrifugation (DGC group. The remaining oocytes from the treatment group were inseminated by sperm chosen according to HOST pattern (c, d or e following DGC processing (HOST group. In the control group (n=63, all oocytes were inseminated by sperm chosen after DGC. Results: There was a significantly higher percentage of embryos that had good quality, implantation, and chemical pregnancy rates in the HOST group compared to the DGC group (p≤0.05. Conclusion: This study has shown that selecting sperm according to membrane functionality (HOST pattern rather morphology and viability may open a new window in our approach for determining the appropriate sperm for ICSI, particularly in individuals with severe male infertility (Registration Number: IRCT201307087223N2.

  3. Preliminary Assessment of Detection Efficiency for the Geostationary Lightning Mapper Using Intercomparisons with Ground-Based Systems

    Science.gov (United States)

    Bateman, Monte; Mach, Douglas; Blakeslee, Richard J.; Koshak, William

    2018-01-01

    As part of the calibration/validation (cal/val) effort for the Geostationary Lightning Mapper (GLM) on GOES-16, we need to assess instrument performance (detection efficiency and accuracy). One major effort is to calculate the detection efficiency of GLM by comparing to multiple ground-based systems. These comparisons will be done pair-wise between GLM and each other source. A complication in this process is that the ground-based systems sense different properties of the lightning signal than does GLM (e.g., RF vs. optical). Also, each system has a different time and space resolution and accuracy. Preliminary results indicate that GLM is performing at or above its specification.

  4. Preliminary Assessment of Potential Avian Interactions at Four Proposed Wind Energy Facilities on Vandenberg Air Force Base, California

    Energy Technology Data Exchange (ETDEWEB)

    2004-08-01

    The United States Air Force (USAF) is investigating whether to install wind turbines to provide a supplemental source of electricity at Vandenberg Air Force Base (VAFB) near Lompoc, California. As part of that investigation, VAFB sought assistance from the U.S. Department of Energy's National Renewable Energy Laboratory (NREL) to provide a preliminary characterization of the potential risk to wildlife resources (mainly birds and bats) from wind turbine installations. With wind power development expanding throughout North America and Europe, concerns have surfaced over the number of bird fatalities associated with wind turbines. Guidelines developed for the wind industry by the National Wind Coordinating Committee (NWCC) recommend assessing potential impacts to birds, bats, and other potentially sensitive resources before construction. The primary purpose of an assessment is to identify potential conflicts with sensitive resources, to assist developers with identifying their permitting needs, and to develop strategies to avoid impacts or to mitigate their effects. This report provides a preliminary (Phase I) biological assessment of potential impacts to birds and bats that might result from construction and operation of the proposed wind energy facilities on VAFB.

  5. Feasibility, safety, acceptability, and preliminary efficacy of measurement-based care depression treatment for HIV patients in Bamenda, Cameroon.

    Science.gov (United States)

    Pence, Brian W; Gaynes, Bradley N; Atashili, Julius; O'Donnell, Julie K; Kats, Dmitry; Whetten, Kathryn; Njamnshi, Alfred K; Mbu, Tabenyang; Kefie, Charles; Asanji, Shantal; Ndumbe, Peter

    2014-06-01

    Depression affects 18-30 % of HIV-infected patients in Africa and is associated with greater stigma, lower antiretroviral adherence, and faster disease progression. However, the region's health system capacity to effectively identify and treat depression is limited. Task-shifting models may help address this large mental health treatment gap. Measurement-Based Care (MBC) is a task-shifting model in which a Depression Care Manager guides a non-psychiatric (e.g., HIV) provider in prescribing and managing antidepressant treatment. We adapted MBC for depressed HIV-infected patients in Cameroon and completed a pilot study to assess feasibility, safety, acceptability, and preliminary efficacy. We enrolled 55 participants; all started amitriptyline 25-50 mg daily at baseline. By 12 weeks, most remained at 50 mg daily (range 25-125 mg). Median (interquartile range) PHQ-9 depressive severity scores declined from 13 (12-16) (baseline) to 2 (0-3) (week 12); 87 % achieved depression remission (PHQ-9 feasibility, safety, acceptability, and preliminary efficacy in this uncontrolled pilot study. Further research should assess whether MBC could improve adherence and HIV outcomes in this setting.

  6. Preliminary safety evaluation for the Forsmark area. Based on data and site descriptions after the initial site investigation stage

    International Nuclear Information System (INIS)

    Andersson, Johan

    2005-08-01

    effects of channelling on radionuclide migration. However, this can only partly be achieved by new measurement approaches. The assessed migration properties of the rock matrix comply with the preferred values. However, the values are based on few samples only and evaluation of more samples would thus further substantiate this conclusion. Better feedback on this issue will be available in relation to the full migration analysis made within the on-going full safety assessment SR-Can. The assessments made for the PSE also suggest some implications for design, some of which are of a generic character to be considered also for the other sites. The most important such feedbacks are: Compared with the actual safety requirement for long-term mechanical stability of deposition holes, the design rules for discarding canister positions due to potential intersections with large fractures or deformation zones seem to be too restrictive. For this reason SKB has now started a project aiming at estimating the probability of actually finding the deposition holes intersected by large fractures. This assessment will also produce more realistic estimates of the degree-of-utilisation. The 6 m spacing of canister deposition holes, suggested in the repository design, appears sufficient. At least locally, it may be possible to use even shorter canister spacing, or to reduce the spacing between the deposition tunnels, but this would require a more detailed understanding of the spatial variability of the thermal properties. Finally, this PSE also highlights issues that would have to be considered if the Forsmark area were to be assessed in a full safety assessment. Important such issues are assessing the probability of identifying large fractures intersecting potential deposition holes, assessing likelihood and the consequences of thermal spalling of deposition holes, and assessing the consequences of the very low permeability of the rock mass

  7. Preliminary safety evaluation for the Forsmark area. Based on data and site descriptions after the initial site investigation stage

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, Johan [JA Streamflow AB, Aelvsjoe (Sweden)

    2005-08-01

    the effects of channelling on radionuclide migration. However, this can only partly be achieved by new measurement approaches. The assessed migration properties of the rock matrix comply with the preferred values. However, the values are based on few samples only and evaluation of more samples would thus further substantiate this conclusion. Better feedback on this issue will be available in relation to the full migration analysis made within the on-going full safety assessment SR-Can. The assessments made for the PSE also suggest some implications for design, some of which are of a generic character to be considered also for the other sites. The most important such feedbacks are: Compared with the actual safety requirement for long-term mechanical stability of deposition holes, the design rules for discarding canister positions due to potential intersections with large fractures or deformation zones seem to be too restrictive. For this reason SKB has now started a project aiming at estimating the probability of actually finding the deposition holes intersected by large fractures. This assessment will also produce more realistic estimates of the degree-of-utilisation. The 6 m spacing of canister deposition holes, suggested in the repository design, appears sufficient. At least locally, it may be possible to use even shorter canister spacing, or to reduce the spacing between the deposition tunnels, but this would require a more detailed understanding of the spatial variability of the thermal properties. Finally, this PSE also highlights issues that would have to be considered if the Forsmark area were to be assessed in a full safety assessment. Important such issues are assessing the probability of identifying large fractures intersecting potential deposition holes, assessing likelihood and the consequences of thermal spalling of deposition holes, and assessing the consequences of the very low permeability of the rock mass.

  8. The Art Gallery Test: A Preliminary Comparison between Traditional Neuropsychological and Ecological VR-Based Tests

    Directory of Open Access Journals (Sweden)

    Pedro Gamito

    2017-11-01

    Full Text Available Ecological validity should be the cornerstone of any assessment of cognitive functioning. For this purpose, we have developed a preliminary study to test the Art Gallery Test (AGT as an alternative to traditional neuropsychological testing. The AGT involves three visual search subtests displayed in a virtual reality (VR art gallery, designed to assess visual attention within an ecologically valid setting. To evaluate the relation between AGT and standard neuropsychological assessment scales, data were collected on a normative sample of healthy adults (n = 30. The measures consisted of concurrent paper-and-pencil neuropsychological measures [Montreal Cognitive Assessment (MoCA, Frontal Assessment Battery (FAB, and Color Trails Test (CTT] along with the outcomes from the three subtests of the AGT. The results showed significant correlations between the AGT subtests describing different visual search exercises strategies with global and specific cognitive measures. Comparative visual search was associated with attention and cognitive flexibility (CTT; whereas visual searches involving pictograms correlated with global cognitive function (MoCA.

  9. The Development of a Canine Anorectal Autotransplantation Model Based on Blood Supply: A Preliminary Case Report

    Science.gov (United States)

    Nakamura, Tatsuo; Sato, Tomoyuki; Naito, Munekazu; Fujii, Satoshi; Mihara, Makoto; Koshima, Isao

    2012-01-01

    Colostomy is conventionally the only treatment for anal dysfunction. Recently, a few trials of anorectal transplantation in animals have been published; however, further development of this technique is required. Moreover, it is crucial to perform this research in dogs, which resemble humans in anorectal anatomy and biology. We designed a canine anorectal transplantation model, wherein anorectal autotransplantation was performed by anastomoses of the rectum, inferior mesenteric artery (IMA) and vein, and pudendal nerves. Resting pressure in the anal canal and anal canal pressure fluctuation were measured before and after surgery. Graft pathology was examined three days after surgery. The anal blood supply was compared with that in three beagles using indocyanine green (ICG) fluorescence angiography. The anorectal graft had sufficient arterial blood supply from the IMA; however, the graft’s distal end was congested and necrotized. Functional examination demonstrated reduced resting pressure and the appearance of an irregular anal canal pressure wave after surgery. ICG angiography showed that the pudendal arteries provided more blood flow than the IMA to the anal segment. This is the first canine model of preliminary anorectal autotransplantation, and it demonstrates the possibility of establishing a transplantation model in dogs using appropriate vascular anastomoses, thus contributing to the progress of anorectal transplantation. PMID:22970198

  10. Preliminary evidence for a unique role of disgust-based conditioning in posttraumatic stress.

    Science.gov (United States)

    Badour, Christal L; Feldner, Matthew T; Blumenthal, Heidemarie; Knapp, Ashley

    2013-04-01

    Independent lines of evidence have linked posttraumatic stress symptomatology to both peritraumatic disgust (i.e., disgust experienced during a traumatic event) and posttraumatic disgust reactivity in response to traumatic event cues among individuals exposed to traumatic events. Much of this work suggests disgust, defined as a rejection/revulsion response aimed at distancing oneself from a potential source of contamination, may be important in understanding the nature of posttraumatic stress reactions even after accounting for the more frequently studied affective states of fear and anxiety. The current investigation provided a preliminary test of a model of disgust in posttraumatic stress among a sample of 54 community-recruited women with a history sexual victimization. Both peritraumatic disgust (r = .31) and posttraumatic disgust reactivity (r = .42) in response to an idiographic traumatic event script were significantly associated with posttraumatic stress symptom severity. After accounting for variability-associated peritraumatic fear and posttraumatic anxious reactivity, an indirect effect of peritraumatic disgust through posttraumatic disgust reactivity also was found, suggesting that one mechanism through which peritraumatic disgust relates to posttraumatic stress is through its relation with increased posttraumatic disgust reactivity. These findings highlight the importance of further elucidating the nature of disgust in relation to traumatic events and subsequent posttraumatic stress reactions. Copyright © 2013 International Society for Traumatic Stress Studies.

  11. Preliminary focus on the mechanical and antibacterial activity of a PMMA-based bone cement loaded with gold nanoparticles

    Directory of Open Access Journals (Sweden)

    T. Russo

    2017-09-01

    As reported in the literature, the stress distribution may be altered in bones after the implantation of a total joint prosthesis. Some scientific works have also correlated uncemented TKA to a progressive decrease of bone density below the tibial component. Antibiotic-loaded bone cements are commonly employed in conjunction with systemic antibiotics to treat infections. Furthermore, nanoparticles with antimicrobial activity have been widely analysed. Accordingly, the current research was focused on a preliminary analysis of the mechanical and antibacterial activity of a PMMA-based bone cement loaded with gold nanoparticles. The obtained results demonstrated that nanocomposite cements with a specific concentration of gold nanoparticles improved the punching performance and antibacterial activity. However, critical aspects were found in the optimization of the nanocomposite bone cement.

  12. Gaseous electron multiplier-based soft x-ray plasma diagnostics development: Preliminary tests at ASDEX Upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Chernyshova, M., E-mail: maryna.chernyshova@ipplm.pl; Malinowski, K.; Czarski, T.; Kowalska-Strzęciwilk, E. [Institute of Plasma Physics and Laser Microfusion, Hery 23, 01-497 Warsaw (Poland); Wojeński, A.; Poźniak, K. T.; Kasprowicz, G.; Krawczyk, R.; Kolasiński, P.; Zabołotny, W.; Zienkiewicz, P. [Institute of Electronic Systems, Warsaw University of Technology, Nowowiejska 15/19, 00-665 Warsaw (Poland); Vezinet, D.; Herrmann, A. [Max Planck Institute for Plasma Physics, Boltzmannstr. 2, 85748 Garching (Germany); Mazon, D.; Jardin, A. [CEA, IRFM, F-13108 Saint-Paul-lez-Durance (France)

    2016-11-15

    A Gaseous Electron Multiplier (GEM)-based detector is being developed for soft X-ray diagnostics on tokamaks. Its main goal is to facilitate transport studies of impurities like tungsten. Such studies are very relevant to ITER, where the excessive accumulation of impurities in the plasma core should be avoided. This contribution provides details of the preliminary tests at ASDEX Upgrade (AUG) with a focus on the most important aspects for detector operation in harsh radiation environment. It was shown that both spatially and spectrally resolved data could be collected, in a reasonable agreement with other AUG diagnostics. Contributions to the GEM signal include also hard X-rays, gammas, and neutrons. First simulations of the effect of high-energy photons have helped understanding these contributions.

  13. Preliminary Results from Powell Research Group on Integrating GRACE Satellite and Ground-based Estimates of Groundwater Storage Changes

    Science.gov (United States)

    Scanlon, B. R.; Zhang, Z.; Reitz, M.; Rodell, M.; Sanford, W. E.; Save, H.; Wiese, D. N.; Croteau, M. J.; McGuire, V. L.; Pool, D. R.; Faunt, C. C.; Zell, W.

    2017-12-01

    Groundwater storage depletion is a critical issue for many of the major aquifers in the U.S., particularly during intense droughts. GRACE (Gravity Recovery and Climate Experiment) satellite-based estimates of groundwater storage changes have attracted considerable media attention in the U.S. and globally and interest in GRACE products continues to increase. For this reason, a Powell Research Group was formed to: (1) Assess variations in groundwater storage using a variety of GRACE products and other storage components (snow, surface water, and soil moisture) for major aquifers in the U.S., (2) Quantify long-term trends in groundwater storage from ground-based monitoring and regional and national modeling, and (3) Use ground-based monitoring and modeling to interpret GRACE water storage changes within the context of extreme droughts and over-exploitation of groundwater. The group now has preliminary estimates from long-term trends and seasonal fluctuations in water storage using different GRACE solutions, including CSR, JPL and GSFC. Approaches to quantifying uncertainties in GRACE data are included. This work also shows how GRACE sees groundwater depletion in unconfined versus confined aquifers, and plans for future work will link GRACE data to regional groundwater models. The wealth of ground-based observations for the U.S. provides a unique opportunity to assess the reliability of GRACE-based estimates of groundwater storage changes.

  14. Preliminary physiologically based pharmacokinetic models for benzo[a]pyrene and dibenzo[def,p]chrysene in rodents

    International Nuclear Information System (INIS)

    Crowell, Susan Ritger; Amin, Shantu G.; Anderson, Kim A.; Krishnegowda, Gowdahalli; Sharma, Arun K.; Soelberg, Jolen J.; Williams, David E.; Corley, Richard A.

    2011-01-01

    Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants generated as byproducts of natural and anthropogenic combustion processes. Despite significant public health concern, physiologically based pharmacokinetic (PBPK) modeling efforts for PAHs have so far been limited to naphthalene, plus simpler PK models for pyrene, nitropyrene, and benzo[a]pyrene (B[a]P). The dearth of published models is due in part to the high lipophilicity, low volatility, and myriad metabolic pathways for PAHs, all of which present analytical and experimental challenges. Our research efforts have focused upon experimental approaches and initial development of PBPK models for the prototypic PAH, B[a]P, and the more potent, albeit less studied transplacental carcinogen, dibenzo[def,p]chrysene (DBC). For both compounds, model compartments included arterial and venous blood, flow limited lung, liver, richly perfused and poorly perfused tissues, diffusion limited fat, and a two compartment theoretical gut (for oral exposures). Hepatic and pulmonary metabolism was described for both compounds, as were fractional binding in blood and fecal clearance. Partition coefficients for parent PAH along with their diol and tetraol metabolites were estimated using published algorithms and verified experimentally for the hydroxylated metabolites. The preliminary PBPK models were able to describe many, but not all, of the available data sets, comprising multiple routes of exposure (oral, intravenous) and nominal doses spanning several orders of magnitude. Supported by Award Number P42 ES016465 from the National Institute of Environmental Health Sciences. -- Highlights: ► We present PBPK models for benzo[a]pyrene (B[a]P) and dibenzo[def,p]chrysene (DBC). ► B[a]P model accurately predicts data from multiple sources over a wide dose range. ► DBC model was based on the B[a]P model as less chemical specific data is available. ► DBC model accurately predicted preliminary

  15. Computer-Aided Diagnosis Based on Convolutional Neural Network System for Colorectal Polyp Classification: Preliminary Experience.

    Science.gov (United States)

    Komeda, Yoriaki; Handa, Hisashi; Watanabe, Tomohiro; Nomura, Takanobu; Kitahashi, Misaki; Sakurai, Toshiharu; Okamoto, Ayana; Minami, Tomohiro; Kono, Masashi; Arizumi, Tadaaki; Takenaka, Mamoru; Hagiwara, Satoru; Matsui, Shigenaga; Nishida, Naoshi; Kashida, Hiroshi; Kudo, Masatoshi

    2017-01-01

    Computer-aided diagnosis (CAD) is becoming a next-generation tool for the diagnosis of human disease. CAD for colon polyps has been suggested as a particularly useful tool for trainee colonoscopists, as the use of a CAD system avoids the complications associated with endoscopic resections. In addition to conventional CAD, a convolutional neural network (CNN) system utilizing artificial intelligence (AI) has been developing rapidly over the past 5 years. We attempted to generate a unique CNN-CAD system with an AI function that studied endoscopic images extracted from movies obtained with colonoscopes used in routine examinations. Here, we report our preliminary results of this novel CNN-CAD system for the diagnosis of colon polyps. A total of 1,200 images from cases of colonoscopy performed between January 2010 and December 2016 at Kindai University Hospital were used. These images were extracted from the video of actual endoscopic examinations. Additional video images from 10 cases of unlearned processes were retrospectively assessed in a pilot study. They were simply diagnosed as either an adenomatous or nonadenomatous polyp. The number of images used by AI to learn to distinguish adenomatous from nonadenomatous was 1,200:600. These images were extracted from the videos of actual endoscopic examinations. The size of each image was adjusted to 256 × 256 pixels. A 10-hold cross-validation was carried out. The accuracy of the 10-hold cross-validation is 0.751, where the accuracy is the ratio of the number of correct answers over the number of all the answers produced by the CNN. The decisions by the CNN were correct in 7 of 10 cases. A CNN-CAD system using routine colonoscopy might be useful for the rapid diagnosis of colorectal polyp classification. Further prospective studies in an in vivo setting are required to confirm the effectiveness of a CNN-CAD system in routine colonoscopy. © 2017 S. Karger AG, Basel.

  16. Preliminary Assessment of Radiofrequency Radiation Exposure Level, From Mobile Base Stations in Ajaokuta and Environs, Kogi State, Nigeria

    International Nuclear Information System (INIS)

    Ushie, P. O.; Nwankwo, U.J.V.; Osahun, O. D.; Ayinmode, B.

    2013-01-01

    We present the result of a preliminary assessment of radio-frequency radiation exposure from selected mobile base stations in Ajaokuta environs using radio frequency (RF) meter (electromoge meter). The Power density of RF radiation within a radial distance of 125m was measured. Although values fluctuated due to the influence of unavoidable factors suspected to be interferences from other electromagnetic sources around reference base stations, we show from analysis that radiation exposure level is far below the standard limit (10W/cm 2 or 10 7 μW/m 2 ) set by the International Commission on Non-ionizing Radiation Protection (ICNIRP) regulatory agencies. The assessment was done in about ten (10) base stations in Ajaokuta, Kogi state. The position and elevation of the base stations were noted using a global positioning system (GPS) to ascertain the position of such stations on the world map. It was discovered that the limit of exposure to radio frequency radiation set by International Commission on Non-ionizing, Radiation Protection (ICNIRP) of 900MHz band expressed in the same unit as 10W/cm 2 or 10 7 μW/m 2 was not exceeded, the values were also influenced by some inevitable factors. Positions of most of the stations are sited close to homes.

  17. SU-E-T-632: Preliminary Study On Treating Nose Skin Using Energy and Intensity Modulated Electron Beams with Monte Carlo Based Dose Calculations

    International Nuclear Information System (INIS)

    Jin, L; Eldib, A; Li, J; Price, R; Ma, C

    2015-01-01

    Purpose: Uneven nose surfaces and air cavities underneath and the use of bolus present complexity and dose uncertainty when using a single electron energy beam to plan treatments of nose skin with a pencil beam-based planning system. This work demonstrates more accurate dose calculation and more optimal planning using energy and intensity modulated electron radiotherapy (MERT) delivered with a pMLC. Methods: An in-house developed Monte Carlo (MC)-based dose calculation/optimization planning system was employed for treatment planning. Phase space data (6, 9, 12 and 15 MeV) were used as an input source for MC dose calculations for the linac. To reduce the scatter-caused penumbra, a short SSD (61 cm) was used. Our previous work demonstrates good agreement in percentage depth dose and off-axis dose between calculations and film measurement for various field sizes. A MERT plan was generated for treating the nose skin using a patient geometry and a dose volume histogram (DVH) was obtained. The work also shows the comparison of 2D dose distributions between a clinically used conventional single electron energy plan and the MERT plan. Results: The MERT plan resulted in improved target dose coverage as compared to the conventional plan, which demonstrated a target dose deficit at the field edge. The conventional plan showed higher dose normal tissue irradiation underneath the nose skin while the MERT plan resulted in improved conformity and thus reduces normal tissue dose. Conclusion: This preliminary work illustrates that MC-based MERT planning is a promising technique in treating nose skin, not only providing more accurate dose calculation, but also offering an improved target dose coverage and conformity. In addition, this technique may eliminate the necessity of bolus, which often produces dose delivery uncertainty due to the air gaps that may exist between the bolus and skin

  18. Retention of Statistical Concepts in a Preliminary Randomization-Based Introductory Statistics Curriculum

    Science.gov (United States)

    Tintle, Nathan; Topliff, Kylie; VanderStoep, Jill; Holmes, Vicki-Lynn; Swanson, Todd

    2012-01-01

    Previous research suggests that a randomization-based introductory statistics course may improve student learning compared to the consensus curriculum. However, it is unclear whether these gains are retained by students post-course. We compared the conceptual understanding of a cohort of students who took a randomization-based curriculum (n = 76)…

  19. Evidence-Based Mental Health Practices with Children Self-Efficacy Scale: Development and Preliminary Findings

    Science.gov (United States)

    McMeel, Lorri S.; Leathers, Sonya J.; Strand, Tonya C.

    2017-01-01

    This article reviews existing measures related to evidence-based practices with children and self-efficacy and describes the development and psychometric properties of the Evidence-Based Mental Health Practices With Children Efficacy Scale. This scale was developed to assess students' and clinicians' self-efficacy in their abilities to use…

  20. Preliminary Study of the Effect of Low-Intensity Home-Based Physical Therapy in Chronic Stroke Patients

    Directory of Open Access Journals (Sweden)

    Jau-Hong Lin

    2004-01-01

    Full Text Available This study was a preliminary examination of the effect of low-intensity home-based physical therapy on the performance of activities of daily living (ADL and motor function in patients more than 1 year after stroke. Twenty patients were recruited from a community stroke register in Nan-Tou County, Taiwan, to a randomized, crossover trial comparing intervention by a physical therapist immediately after entry into the trial (Group I or after a delay of 10 weeks (Group II. The intervention consisted of home-based physical therapy once a week for 10 weeks. The Barthel Index (BI and Stroke Rehabilitation Assessment of Movement (STREAM were used as standard measures for ADL and motor function. At the first follow-up assessment at 11 weeks, Group I showed greater improvement in lower limb motor function than Group II. At the second follow-up assessment at 22 weeks, Group II showed improvement while Group I had declined. At 22 weeks, the motor function of upper limbs, mobility, and ADL performance in Group II had improved slightly more than in Group I, but the between-group differences were not significant. It appears that low-intensity home-based physical therapy can improve lower limb motor function in chronic stroke survivors. Further studies will be needed to confirm these findings.

  1. Snakebites in French Guiana: Conclusions of an international symposium.

    Science.gov (United States)

    Kallel, Hatem; Hommel, Didier; Mehdaoui, Hossein; Megarbane, Bruno; Resiere, Dabor

    2018-05-01

    A workshop on epidemiology and management of snakebites in French Guiana was performed at Cayenne, French Guiana from September 15 to September 16, 2017, under the auspices of the French Regional Health Agency (ARS) and the Pan American Health Organization (PAHO). The activity was attended by experts from France (Angers, Martinique, French Guiana, Guadeloupe, and Paris), Costa Rica, Brazil, Saint Lucia, and Surinam. The epidemiology, clinical manifestations, clinical grading and the management of snakebite in French Guiana were discussed. The conclusions of this symposium illustrated the urgent need to ensure accessibility of effective and safe polyvalent viperid antivenom in French Guiana. Finally, the results of this symposium have forged ties based on mutual goals and objectives. Copyright © 2018 Elsevier Ltd. All rights reserved.

  2. Primary progressive aphasia patients evaluated using diffusion tensor imaging and voxel based volumetry-preliminary results

    Directory of Open Access Journals (Sweden)

    Fábio Pascotto de Oliveira

    2011-06-01

    Full Text Available There are individuals who have a progressive language deficit without presenting cognitive deficits in other areas. One of the diseases related to this presentation is primary progressive aphasia (PPA. OBJECTIVE: Identify by means of diffusion tensor imaging (DTI and measurements of cortical volume, brain areas that lead to dysphasia when presenting signs of impaired connectivity or reduced volume. METHOD: Four patients with PPA were evaluated using DTI, and measurements of cortical volumes in temporal areas. These patients were compared with two normal volunteers. RESULTS: There is a trend to a difference in the number and volume of related fibers between control group and patients with PPA. Comparing cortical volumes in temporal areas between groups yielded a trend to a smaller volume in PPA patients. CONCLUSION: Patients with PPA have a trend to impairment in cortical and subcortical levels regarding relevant areas.

  3. Game-Based Cognitive-Behavioral Therapy (GB-CBT) Group Program for Children Who Have Experienced Sexual Abuse: A Preliminary Investigation

    Science.gov (United States)

    Misurell, Justin R.; Springer, Craig; Tryon, Warren W.

    2011-01-01

    This preliminary investigation examined the efficacy of a game-based cognitive-behavioral therapy group program for elementary school-aged children who have experienced sexual abuse. Treatment aimed to improve: (a) internalizing symptoms, (b) externalizing behaviors, (c) sexually inappropriate behaviors, (d) social skills deficits, (e) self-esteem…

  4. Preliminary energy demand studies for Ireland: base case and high case for 1980, 1985 and 1990

    Energy Technology Data Exchange (ETDEWEB)

    Henry, E W

    1981-01-01

    The framework of the Base Case and the High Case for 1990 for Ireland, related to the demand modules of the medium-term European Communities (EC) Energy Model, is described. The modules are: Multi-national Macre-economic Module (EURECA); National Input-Output Model (EXPLOR); and National Energy Demand Model (EDM). The final results of the EXPLOR and EDM are described; one set related to the Base Case and the other related to the High Case. The forecast or projection is termed Base Case because oil prices are assumed to increase with general price inflation, at the same rate. The other forecast is termed High Case because oil prices are assumed to increase at 5% per year more rapidly than general price inflation. The EXPLOR-EDM methodology is described. The lack of data on energy price elasticities for Ireland is noted. A comparison of the Base Case with the High Case is made. (MCW)

  5. Preliminary development and evaluation of an appearance-based dissonance induction intervention for reducing UV exposure.

    Science.gov (United States)

    Chait, Sari R; Thompson, J Kevin; Jacobsen, Paul B

    2015-01-01

    The current study examined the feasibility of an appearance-based dissonance induction approach for the modification of tanning and sunscreen use behaviors. Undergraduate female students were randomized to: a healthy lifestyle condition, an appearance-based dissonance condition, or an appearance-based psychoeducation condition. Reports of tanning and sunscreen use were collected immediately before and 1 month following intervention (N=225). Relative to the healthy lifestyle condition, participants in the dissonance condition reported a significant reduction in daily hours spent tanning. Additionally, sunscreen use on the body decreased significantly for the healthy lifestyle group, but did not change for the dissonance group. The psychoeducation condition did not differ from the healthy lifestyle condition on any measure. These findings should encourage additional research into the use of dissonance induction as an appearance-based strategy for promoting reductions in UV exposure. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. Preliminary Evaluation of the Computer-Based Tactics Certification Course--Principles of War Module

    National Research Council Canada - National Science Library

    Pleban, Robert

    1997-01-01

    This report describes a portion of the U.S. Army Research Institute for the Behavioral and Social Sciences Infantry Forces Research Unit's work in the formative evaluation of the computer based Tactics Certification Course (TCC...

  7. [Preliminary study of bonding strength between diatomite-based dental ceramic and veneering porcelains].

    Science.gov (United States)

    Lu, Xiao-li; Gao, Mei-qin; Cheng, Yu-ye; Zhang, Fei-min

    2015-04-01

    In order to choose the best veneering porcelain for diatomite-based dental ceramic substrate, the bonding strength between diatomite-based dental ceramics and veneering porcelains was measured, and the microstructure and elements distribution of interface were analyzed. The coefficient of thermal expansion (CTE) of diatomite-based dental ceramics was detected by dilatometry. Three veneering porcelain materials were selected with the best CTE matching including alumina veneering porcelain (group A), titanium porcelain veneering porcelain (group B), and E-max veneering porcelain (group C). Shear bonding strength was detected. SEM and EDS were used to observe the interface microstructure and element distribution. Statistical analysis was performed using SPSS 17.0 software package. The CTE of diatomite-based dental ceramics at 25-500 degrees centigrade was 8.85×10-6K-1. The diatomite-based substrate ceramics combined best with group C. Shear bonding strength between group A and C and group B and C both showed significant differences(P<0.05). SEM and EDS showed that the interface of group C sintered tightly and elements permeated on both sides of the interface. The diatomite-based substrate ceramics combines better with E-max porcelain veneer.

  8. A preliminary study on cone beam CT image based treatment planning

    International Nuclear Information System (INIS)

    Padmanaban, Sriram; Jeevanandham, Prakash; Boopathy, Raghavendiran; Sukumar, Prabakar; Syam Kumar, S.A.; Kunjithapatham, Bhuvana; Nagarajan, Vivekanandan

    2008-01-01

    Kilovolt Cone beam computed tomography (CBCT) based on flat panel technology is primarily used for positioning verification. However it is required to evaluate the accuracy of dose calculation based on CBCT images for the purpose of re-planning in adaptive radiation therapy (ART). In this study, 3DCRT and IMRT plans were done using both the planning CT and CBCT images and the corresponding variations in dose and MUs were analyzed, hence evaluating the feasibility of using kilovolt CBCT for dose calculation and patient dose verification. (author)

  9. Preliminary results of a new workflow for MRI/CT-based image-guided brachytherapy in cervical carcinoma.

    Science.gov (United States)

    Nemoto, Miho Watanabe; Iwai, Yuma; Togasaki, Gentaro; Kurokawa, Marie; Harada, Rintarou; Kobayashi, Hiroki; Uno, Takashi

    2017-12-01

    We propose a method of image-guided brachytherapy (IGBT) that combines MRI-based target volume delineation for the first fraction with CT datasets of subsequent fractions, using an automatic, applicator-based co-registration, and report our preliminary experience. The MRI of the first fraction was used for the first brachytherapy planning. For each subsequent brachytherapy fraction, after the same applicator insertion, a new CT scan with the applicator in place was obtained. The MR image set was registered to the subsequent brachytherapy treatment planning CT using the applicator for rigid body registration. To demonstrate the registration quality, we used here the Dice index as a measurement of tandem delineation overlap between CT and MRI. The median Dice index was 0.879 (range 0.610-0.932), which indicated that the contours on CT and MRI fitted well. With this combination method, the median D90 of HR CTV and the calculated D2 cm 3 of the bladder, rectum, and sigmoid in each fraction were 7.2 (4.0-10.4), 5.9 (2.3-7.7), 4.0 (1.9-6.7), and 3.8 (0.6-7.2) Gy, respectively. Our described method of MRI-guided IGBT offers a practical option for the benefits of target delineation.

  10. Relation of Habitual Chocolate Consumption to Arterial Stiffness in a Community-Based Sample: Preliminary Findings

    Science.gov (United States)

    Crichton, Georgina E.; Elias, Merrill F.; Alkerwi, Ala'a; Stranges, Saverio; Abhayaratna, Walter P.

    2016-01-01

    Background The consumption of chocolate and cocoa has established cardiovascular benefits. Less is known about the effects of chocolate on arterial stiffness, a marker of subclinical cardiovascular disease. The aim of this study was to investigate whether chocolate intakes are independently associated with pulse wave velocity (PWV), after adjustment for cardiovascular, lifestyle and dietary factors. Methods Prospective analyses were undertaken on 508 community-dwelling participants (mean age 61 years, 60% women) from the Maine-Syracuse Longitudinal Study (MSLS). Habitual chocolate intakes, measured using a food frequency questionnaire, were related to PWV, measured approximately 5 years later. Results Chocolate intake was significantly associated with PWV in a non-linear fashion with the highest levels of PWV in those who never or rarely ate chocolate and lowest levels in those who consumed chocolate once a week. This pattern of results remained and was not attenuated after multivariate adjustment for diabetes, cardiovascular risk factors and dietary variables (p = 0.002). Conclusions Weekly chocolate intake may be of benefit to arterial stiffness. Further studies are needed to explore the underlying mechanisms that may mediate the observed effects of habitual chocolate consumption on arterial stiffness. PMID:27493901

  11. Cerebral Reorganization in Subacute Stroke Survivors after Virtual Reality-Based Training: A Preliminary Study

    Directory of Open Access Journals (Sweden)

    Xiang Xiao

    2017-01-01

    Full Text Available Background. Functional magnetic resonance imaging (fMRI is a promising method for quantifying brain recovery and investigating the intervention-induced changes in corticomotor excitability after stroke. This study aimed to evaluate cortical reorganization subsequent to virtual reality-enhanced treadmill (VRET training in subacute stroke survivors. Methods. Eight participants with ischemic stroke underwent VRET for 5 sections per week and for 3 weeks. fMRI was conducted to quantify the activity of selected brain regions when the subject performed ankle dorsiflexion. Gait speed and clinical scales were also measured before and after intervention. Results. Increased activation in the primary sensorimotor cortex of the lesioned hemisphere and supplementary motor areas of both sides for the paretic foot (p<0.01 was observed postintervention. Statistically significant improvements were observed in gait velocity (p<0.05. The change in voxel counts in the primary sensorimotor cortex of the lesioned hemisphere is significantly correlated with improvement of 10 m walk time after VRET (r=−0.719. Conclusions. We observed improved walking and increased activation in cortical regions of stroke survivors after VRET training. Moreover, the cortical recruitment was associated with better walking function. Our study suggests that cortical networks could be a site of plasticity, and their recruitment may be one mechanism of training-induced recovery of gait function in stroke. This trial is registered with ChiCTR-IOC-15006064.

  12. Development of a computer-based automated pure tone hearing screening device: a preliminary clinical trial.

    Science.gov (United States)

    Gan, Kok Beng; Azeez, Dhifaf; Umat, Cila; Ali, Mohd Alauddin Mohd; Wahab, Noor Alaudin Abdul; Mukari, Siti Zamratol Mai-Sarah

    2012-10-01

    Hearing screening is important for the early detection of hearing loss. The requirements of specialized equipment, skilled personnel, and quiet environments for valid screening results limit its application in schools and health clinics. This study aimed to develop an automated hearing screening kit (auto-kit) with the capability of realtime noise level monitoring to ensure that the screening is performed in an environment that conforms to the standard. The auto-kit consists of a laptop, a 24-bit resolution sound card, headphones, a microphone, and a graphical user interface, which is calibrated according to the American National Standards Institute S3.6-2004 standard. The auto-kit can present four test tones (500, 1000, 2000, and 4000 Hz) at 25 or 40 dB HL screening cut-off level. The clinical results at 40 dB HL screening cut-off level showed that the auto-kit has a sensitivity of 92.5% and a specificity of 75.0%. Because the 500 Hz test tone is not included in the standard hearing screening procedure, it can be excluded from the auto-kit test procedure. The exclusion of 500 Hz test tone improved the specificity of the auto-kit from 75.0% to 92.3%, which suggests that the auto-kit could be a valid hearing screening device. In conclusion, the auto-kit may be a valuable hearing screening tool, especially in countries where resources are limited.

  13. Improving International-Level Chess Players' Performance with an Acceptance-Based Protocol: Preliminary Findings

    Science.gov (United States)

    Ruiz, Francisco J.; Luciano, Carmen

    2012-01-01

    This study compared an individual, 4-hr intervention based on acceptance and commitment therapy (ACT) versus a no-contact control condition in improving the performance of international-level chess players. Five participants received the brief ACT protocol, with each matched to another chess player with similar characteristics in the control…

  14. Adapting Evidence-Based Mental Health Treatments in Community Settings: Preliminary Results from a Partnership Approach

    Science.gov (United States)

    Southam-Gerow, Michael A.; Hourigan, Shannon E.; Allin, Robert B., Jr.

    2009-01-01

    This article describes the application of a university-community partnership model to the problem of adapting evidence-based treatment approaches in a community mental health setting. Background on partnership research is presented, with consideration of methodological and practical issues related to this kind of research. Then, a rationale for…

  15. Feasibility and Preliminary Outcomes of a School-Based Mindfulness Intervention for Urban Youth

    Science.gov (United States)

    Mendelson, Tamar; Greenberg, Mark T.; Dariotis, Jacinda K.; Gould, Laura Feagans; Rhoades, Brittany L.; Leaf, Philip J.

    2010-01-01

    Youth in underserved, urban communities are at risk for a range of negative outcomes related to stress, including social-emotional difficulties, behavior problems, and poor academic performance. Mindfulness-based approaches may improve adjustment among chronically stressed and disadvantaged youth by enhancing self-regulatory capacities. This paper…

  16. Development and Assessment of a Preliminary Randomization-Based Introductory Statistics Curriculum

    Science.gov (United States)

    Tintle, Nathan; VanderStoep, Jill; Holmes, Vicki-Lynn; Quisenberry, Brooke; Swanson, Todd

    2011-01-01

    The algebra-based introductory statistics course is the most popular undergraduate course in statistics. While there is a general consensus for the content of the curriculum, the recent Guidelines for Assessment and Instruction in Statistics Education (GAISE) have challenged the pedagogy of this course. Additionally, some arguments have been made…

  17. Preliminary Performance Evaluation of MEMS-based Piezoelectric Energy Harvesters in Extended Temperature Range

    DEFF Research Database (Denmark)

    Xu, R.; Borregaard, L.M.; Lei, A.

    2012-01-01

    In this work a batch of MEMS-based vibration energy harvesters consisting of a silicon/PZT thick film ntilever with integrated proof mass is characterized. The purpose of a vibration energy harvester is to convert low grade vibrations to useful electrical power. Optimally, the natural frequency...

  18. Vedic Science Based Education and Nonverbal Intelligence: A Preliminary Longitudinal Study in Cambodia.

    Science.gov (United States)

    Fergusson, Lee C.; And Others

    1996-01-01

    A study investigated the effects on students' nonverbal intelligence of implementing an approach to higher education based on Vedic science, developed by Maharishi Mahesh Yogi and including transcendental meditation. The approach was implemented in two Cambodian universities and its effects assessed in 70 undergraduate students. An increase in…

  19. An Unexpected Means of Embedding Ethics in Organizations: Preliminary Findings from Values-Based Evaluations

    Directory of Open Access Journals (Sweden)

    Gemma Burford

    2016-06-01

    Full Text Available Ethical principles constitute a crucial area of debate and discussion in the global conversation around transitions to sustainability, and of particular relevance to the contribution of businesses and other organizations. Scholars in business ethics have recently identified several challenges in this area, such as problems of measurement, rigor, and meaningfulness to practitioners; corporate social responsibility; and institutionalization of ethics in businesses. In this paper, the impacts of a pragmatic values-based evaluation approach originally developed in another field—education for sustainable development—are shown to strongly contribute to many of these challenges. Impacts found across eight organizations include (i deep values conceptualization; (ii increased esteem (iii building capacity for assessment of values-based achievements; (iv values mainstreaming; and (v effective external values communications. It seems that the in-situ development and use of values-based indicators helped to conceptualize locally shared values that underpin decisions, thus embedding the application of (local ethics. Although this study is exploratory, it is clear that the values-based approach shows promise for meeting key challenges in business ethics and wider sustainability, and for new directions for future cross-disciplinary research.

  20. Identification of listeria species isolated in Tunisia by Microarray based assay : results of a preliminary study

    International Nuclear Information System (INIS)

    Hmaied, Fatma; Helel, Salma; Barkallah, Insaf; Leberre, V.; Francois, J.M.; Kechrid, A.

    2008-01-01

    Microarray-based assay is a new molecular approach for genetic screening and identification of microorganisms. We have developed a rapid microarray-based assay for the reliable detection and discrimination of Listeria spp. in food and clinical isolates from Tunisia. The method used in the present study is based on the PCR amplification of a virulence factor gene (iap gene). the PCR mixture contained cyanine Cy5labeled dCTP. Therefore, The PCR products were fluorescently labeled. The presence of multiple species-specific sequences within the iap gene enabled us to design different oligoprobes per species. The species-specific sequences of the iap gene used in this study were obtained from genBank and then aligned for phylogenetic analysis in order to identify and retrieve the sequences of homologues of the amplified iap gene analysed. 20 probes were used for detection and identification of 22 food isolates and clinical isolates of Listeria spp (L. monocytogenes, L. ivanovi), L. welshimeri, L. seeligeri, and L. grayi). Each bacterial gene was identified by hybridization to oligoprobes specific for each Listeria species and immobilized on a glass surface. The microarray analysis showed that 5 clinical isolates and 2 food isolates were identified listeria monocytogenes. Concerning the remaining 15 food isolates; 13 were identified listeria innocua and 2 isolates could not be identified by microarray based assay. Further phylogenetic and molecular analysis are required to design more species-specific probes for the identification of Listeria spp. Microarray-based assay is a simple and rapid method used for Listeria species discrimination

  1. Summary of the discussion, Conclusion of the meeting

    International Nuclear Information System (INIS)

    Crutzen, S.

    1997-01-01

    The discussion was organised in three major periods corresponding to the main themes developed by the programme of the meeting: the qualification approaches, the qualification experience accumulated so far, one particular frame or motivation of the ISI qualification: the risk based (or informed) ISI. The qualification approaches presented by national representatives raised few questions. More discussion was induced on the qualification concepts, responsibilities, need and writing of the technical justification, motivation for the open trials, similitude between concepts, benefit deriving from the qualification of inspection procedures and further motivation. the conclusion could be as the following: the evolution of qualification applications, even if issued from harmonised concepts, appears to be nationalistically based. It is a thought that emulation and harmonisation could actually produce both savings and improvements in this area. 'The wheel does not have to be re-invented in each country' and it is the declared objective of ENIQ. There seems to be a need for some international agreement in the setting of standards for qualification. One area which seems to continue to be of underlying concern is in the characterisation of defects. There seems to be a need for appropriate 'defected blocks' satisfying the criteria of representativeness, quality, low cost, reproducibility, etc. More specific cases of Technical Justification development are needed to serve as examples and incentive for the case of this element of inspection qualification

  2. Preliminary Analysis of the General Performance and Mechanical Behavior of Irradiated FeCrAl Base Alloys and Weldments

    Energy Technology Data Exchange (ETDEWEB)

    Gussev, Maxim N. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Field, Kevin G. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Briggs, Samuel A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Yamamoto, Yukinori [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-09-30

    The iron-based, iron-chromium-aluminum (FeCrAl) alloys are promising, robust materials for deployment in current and future nuclear power plants. This class of alloys demonstrates excellent performance in a range of environments and conditions, including high-temperature steam (>1000°C). Furthermore, these alloys have the potential to have prolonged survival under loss-of-coolant accident (LOCA) conditions compared to the more traditional cladding materials that are either Zr-based alloys or austenitic steels. However, one of the issues associated with FeCrAl alloys is cracking during welding. The present project investigates the possibility of mitigating welding-induced cracking via alloying and precise structure control of the weldments; in the frame work of the project, several advanced alloys were developed and are being investigated prior to and after neutron irradiation to provide insight into the radiation tolerance and mechanical performance of the weldments. The present report provides preliminary results on the post-irradiation characterization and mechanical tests performed during United States Fiscal Year (FY) 2016. Chapter 1 provides a general introduction, and Chapter 2 describes the alloy compositions, welding procedure, specimen geometry and manufacturing parameters. Also, a brief discussion of the irradiation at the High Flux Isotope Reactor (HFIR) is provided. Chapter 3 is devoted to the analysis of mechanical tests performed at the hot cell facility; tensile curves and mechanical properties are discussed in detail focusing on the irradiation temperature. Limited fractography results are also presented and analyzed. The discussion highlights the limitations of the testing within a hot cell. Chapter 4 underlines the advantages of in-situ testing and discusses the preliminary results obtained with newly developed miniature specimens. Specimens were moved to the Low Activation Materials Development and Analysis (LAMDA) laboratory and prepared for

  3. A preliminary study of breast cancer diagnosis using laboratory based small angle x-ray scattering

    Energy Technology Data Exchange (ETDEWEB)

    Round, A R [Daresbury Laboratories, Warrington, WA4 4AD (United Kingdom); Wilkinson, S J [Daresbury Laboratories, Warrington, WA4 4AD (United Kingdom); Hall, C J [Daresbury Laboratories, Warrington, WA4 4AD (United Kingdom); Rogers, K D [Department of Materials and Medical Sciences, Cranfield University, Swindon, SN6 8LA (United Kingdom); Glatter, O [Department of Chemistry, University of Graz (Austria); Wess, T [School of Optometry and Vision Sciences, Cardiff University, Cardiff CF10 3NB, Wales (United Kingdom); Ellis, I O [Nottingham City Hospital, Nottingham (United Kingdom)

    2005-09-07

    Breast tissue collected from tumour samples and normal tissue from bi-lateral mastectomy procedures were examined using small angle x-ray scattering. Previous work has indicated that breast tissue disease diagnosis could be performed using small angle x-ray scattering (SAXS) from a synchrotron radiation source. The technique would be more useful to health services if it could be made to work using a conventional x-ray source. Consistent and reliable differences in x-ray scatter distributions were observed between samples from normal and tumour tissue samples using the laboratory based 'SAXSess' system. Albeit from a small number of samples, a sensitivity of 100% was obtained. This result encourages us to pursue the implementation of SAXS as a laboratory based diagnosis technique.

  4. A preliminary study of breast cancer diagnosis using laboratory based small angle x-ray scattering

    International Nuclear Information System (INIS)

    Round, A R; Wilkinson, S J; Hall, C J; Rogers, K D; Glatter, O; Wess, T; Ellis, I O

    2005-01-01

    Breast tissue collected from tumour samples and normal tissue from bi-lateral mastectomy procedures were examined using small angle x-ray scattering. Previous work has indicated that breast tissue disease diagnosis could be performed using small angle x-ray scattering (SAXS) from a synchrotron radiation source. The technique would be more useful to health services if it could be made to work using a conventional x-ray source. Consistent and reliable differences in x-ray scatter distributions were observed between samples from normal and tumour tissue samples using the laboratory based 'SAXSess' system. Albeit from a small number of samples, a sensitivity of 100% was obtained. This result encourages us to pursue the implementation of SAXS as a laboratory based diagnosis technique

  5. Computer–Based Procedures for Nuclear Power Plant Field Workers: Preliminary Results from Two Evaluation Studies

    Energy Technology Data Exchange (ETDEWEB)

    Katya L Le Blanc; Johanna H Oxstrand

    2013-10-01

    The Idaho National Laboratory and participants from the U.S. nuclear industry are collaborating on a research effort aimed to augment the existing guidance on computer-based procedure (CBP) design with specific guidance on how to design CBP user interfaces such that they support procedure execution in ways that exceed the capabilities of paper-based procedures (PBPs) without introducing new errors. Researchers are employing an iterative process where the human factors issues and interface design principles related to CBP usage are systematically addressed and evaluated in realistic settings. This paper describes the process of developing a CBP prototype and the two studies conducted to evaluate the prototype. The results indicate that CBPs may improve performance by reducing errors, but may increase the time it takes to complete procedural tasks.

  6. Preliminary characterization of propellants based on p(GA/BAMO) and pAMMO binders

    Energy Technology Data Exchange (ETDEWEB)

    Barbieri, Ugo; Polacco, Giovanni [Department of Chemical Engineering, University of Pisa (Italy); Keicher, Thomas [Fraunhofer-Institut fuer Chemische Technologie (ICT), Pfinztal (Germany); Massimi, Roberto [AVIO S.p.A., Roma (Italy)

    2009-10-15

    In previous papers, the synthesis and characterization of OH-terminated glycidyl azide-r-(3,3-bis(azidomethyl)oxetane) copolymers (GA/BAMO) and poly-3-azidomethyl-3-methyl oxetane (pAMMO) by azidation of their respective polymeric substrates were described. The main objective was the preparation of amorphous azido-polymers, as substitutes of hydroxy-terminated polybutadiene (HTPB) in new formulations of energetic propellants. Here, the subsequent characterization of both the binders is presented. First of all, several isocyanates were checked in order to optimize the curing reaction, and then two small-scale formulations of a propellant, based on aluminium and ammonium perchlorate, were prepared and characterized. Finally, the mechanical properties and burning rate were compared to those of a similar propellant based on HTPB as binder. (Abstract Copyright [2009], Wiley Periodicals, Inc.)

  7. Assessment of statistical education in Indonesia: Preliminary results and initiation to simulation-based inference

    Science.gov (United States)

    Saputra, K. V. I.; Cahyadi, L.; Sembiring, U. A.

    2018-01-01

    Start in this paper, we assess our traditional elementary statistics education and also we introduce elementary statistics with simulation-based inference. To assess our statistical class, we adapt the well-known CAOS (Comprehensive Assessment of Outcomes in Statistics) test that serves as an external measure to assess the student’s basic statistical literacy. This test generally represents as an accepted measure of statistical literacy. We also introduce a new teaching method on elementary statistics class. Different from the traditional elementary statistics course, we will introduce a simulation-based inference method to conduct hypothesis testing. From the literature, it has shown that this new teaching method works very well in increasing student’s understanding of statistics.

  8. A preliminary study of breast cancer diagnosis using laboratory based small angle x-ray scattering

    Science.gov (United States)

    Round, A. R.; Wilkinson, S. J.; Hall, C. J.; Rogers, K. D.; Glatter, O.; Wess, T.; Ellis, I. O.

    2005-09-01

    Breast tissue collected from tumour samples and normal tissue from bi-lateral mastectomy procedures were examined using small angle x-ray scattering. Previous work has indicated that breast tissue disease diagnosis could be performed using small angle x-ray scattering (SAXS) from a synchrotron radiation source. The technique would be more useful to health services if it could be made to work using a conventional x-ray source. Consistent and reliable differences in x-ray scatter distributions were observed between samples from normal and tumour tissue samples using the laboratory based 'SAXSess' system. Albeit from a small number of samples, a sensitivity of 100% was obtained. This result encourages us to pursue the implementation of SAXS as a laboratory based diagnosis technique.

  9. Utilization of Android-base Smartphone to Support Handmade Spectrophotometer : A Preliminary Study

    Science.gov (United States)

    Ujiningtyas, R.; Apriliani, E.; Yohana, I.; Afrillianti, L.; Hikmah, N.; Kurniawan, C.

    2018-04-01

    Visible spectrophotometer is a powerful instrument in chemistry. We can identify the chemical species base on their specific color and then we can also determine the amount of the species using the spectrophotometer. However, the availability of visible spectrophotometer still limited, particularly for education. This affect the skill of student to have experience on handling the instrumentation. On the other hand, the communication technology creates an opportunity for student to explore their smart feature, mainly the camera. The objective of this research is to make an application that utilize the camera feature as a detector for handmade visible spectrophotometer. The software have been made based on android program, and we name it as Spectrophone®. The spectrophotometer consists of an acrylic body, sample compartment, and light sources (USB-LED lamp powered by 6600 mAh battery). Before reach the sample, the light source was filtered using colored-mica plastic. The spectrophone® apps utilize the camera to detect the color based on its RGB composition. A different colored solution will show a different RGB composition based on the concentration and specific absorbance wavelength. We then can choose one type of color composition, R or G or B only to be converted as an absorbance using -Log (Cs/Co), where Cs and Co are color composition of sample and blank, respectively. The calibration curve of metilen blue measured. In a red (R) composition, the regression is not linear (R2=0.78) compare to the result of UV-Vis spectrophotomer model Spectroquant Pharo 300 (R2=0.8053). This measurement result shows that The Spectrophone® still need to be evaluated and corrected. One problem than can we identify that the diameter of pick point of RGB composition is too wide and this will affect the reading color composition. Next, we will fix the problem and in advance we will apply this Spectrophone® in a wide scale.

  10. Incorporation of new tables into the preliminary structure of BDCN - nuclear fuel data base

    International Nuclear Information System (INIS)

    Pombo, J.B.S.; Andrade, M.C.

    1989-01-01

    The structure of the new tables related to fuel elements, fuel rods and fuel pellets have been incorporated into the developing structure of BDCN - nuclear fuel data base, are described. The list of all 44 tables structured up to now, with identification of its primary keys, as well as the reduced set of data has been entered to run the simulations are also presented. The simulation tests have been ran using a microcomputer.(M.I.)

  11. Web-based oral health promotion program for older adults: Development and preliminary evaluation.

    Science.gov (United States)

    Mariño, Rodrigo J; Marwaha, Parul; Barrow, Su-Yan

    2016-07-01

    This study reports on the impact evaluation of a Web-based oral health promotion programme aimed at improving the oral health knowledge, attitudes, practices and self-efficacy of independent-living older adults from Melbourne, Australia. With ethics approval from the University of Melbourne, a convenience sample of volunteers 55 years or older was invited to participate in a study to test a web-based oral health promotion program. Consenting volunteers were asked to undergo a structured interview as part of the pre-intervention data collection. The intervention was based on the ORHIS (Oral Health Information Seminars/Sheets) Model and involved computer interaction with six oral health presentations, with no direct oral health professional input. A one group pre-test-post-test quasi-experimental design was chosen to evaluate the intervention. A series of paired t-tests were used to compare pre-test with post-test results. Forty-seven active, independent-living older adults participated in this evaluation. After the intervention participants responded with higher levels of achievement than before participating in this Web-based oral health program. Participants showed significant improvements in oral health attitudes (4.10 vs. 4.94; p<0.01), knowledge (18.37 vs. 23.83; p<0.0001), and self-efficacy (84.37 vs.89.23; p<0.01), as well as, self-reported oral hygiene practices (i.e., frequency of use of dental floss) (p<0.05). The e-ORHIS approach was successful in improving oral health knowledge, attitudes and self-efficacy. As such, it represents a helpful approach for the design of (oral) health interventions in older adults. Further evaluation with a larger sample is required to test the long-term impact including the economic evaluation of the e-ORHIS approach. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  12. A web-based team-oriented medical error communication assessment tool: development, preliminary reliability, validity, and user ratings.

    Science.gov (United States)

    Kim, Sara; Brock, Doug; Prouty, Carolyn D; Odegard, Peggy Soule; Shannon, Sarah E; Robins, Lynne; Boggs, Jim G; Clark, Fiona J; Gallagher, Thomas

    2011-01-01

    Multiple-choice exams are not well suited for assessing communication skills. Standardized patient assessments are costly and patient and peer assessments are often biased. Web-based assessment using video content offers the possibility of reliable, valid, and cost-efficient means for measuring complex communication skills, including interprofessional communication. We report development of the Web-based Team-Oriented Medical Error Communication Assessment Tool, which uses videotaped cases for assessing skills in error disclosure and team communication. Steps in development included (a) defining communication behaviors, (b) creating scenarios, (c) developing scripts, (d) filming video with professional actors, and (e) writing assessment questions targeting team communication during planning and error disclosure. Using valid data from 78 participants in the intervention group, coefficient alpha estimates of internal consistency were calculated based on the Likert-scale questions and ranged from α=.79 to α=.89 for each set of 7 Likert-type discussion/planning items and from α=.70 to α=.86 for each set of 8 Likert-type disclosure items. The preliminary test-retest Pearson correlation based on the scores of the intervention group was r=.59 for discussion/planning and r=.25 for error disclosure sections, respectively. Content validity was established through reliance on empirically driven published principles of effective disclosure as well as integration of expert views across all aspects of the development process. In addition, data from 122 medicine and surgical physicians and nurses showed high ratings for video quality (4.3 of 5.0), acting (4.3), and case content (4.5). Web assessment of communication skills appears promising. Physicians and nurses across specialties respond favorably to the tool.

  13. MR-based full-body preventative cardiovascular and tumor imaging: technique and preliminary experience

    International Nuclear Information System (INIS)

    Goyen, Mathias; Goehde, Susanne C.; Herborn, Christoph U.; Hunold, Peter; Vogt, Florian M.; Gizewski, Elke R.; Lauenstein, Thomas C.; Ajaj, Waleed; Forsting, Michael; Debatin, Joerg F.; Ruehm, Stefan G.

    2004-01-01

    Recent improvements in hardware and software, lack of side effects, as well as diagnostic accuracy make magnetic resonance imaging a natural candidate for preventative imaging. Thus, the purpose of the study was to evaluate the feasibility of a comprehensive 60-min MR-based screening examination in healthy volunteers and a limited number of patients with known target disease. In ten healthy volunteers (7 men, 3 women; mean age, 32.4 years) and five patients (4 men, 1 woman; mean age, 56.2 years) with proven target disease we evaluated the performance of a comprehensive MR screening strategy by combining well-established organ-based MR examination components encompassing the brain, the arterial system, the heart, the lungs, and the colon. All ten volunteers and five patients tolerated the comprehensive MR examination well. The mean in-room time was 63 min. In one volunteer, insufficient colonic cleansing on the part of the volunteer diminished the diagnostic reliability of MR colonography. All remaining components of the comprehensive MR examination were considered diagnostic in all volunteers and patients. In the five patients, the examination revealed the known pathologies [aneurysm of the anterior communicating artery (n=1), renal artery stenosis (n=1), myocardial infarct (n=1), and colonic polyp (n=2)]. The outlined MR screening strategy encompassing the brain, the arterial system, the heart, the lung, and the colon is feasible. Further studies have to show that MR-based screening programs are cost-effective in terms of the life-years saved. (orig.)

  14. Internet-Based Self-Help Intervention for ICD-11 Adjustment Disorder: Preliminary Findings.

    Science.gov (United States)

    Eimontas, Jonas; Rimsaite, Zivile; Gegieckaite, Goda; Zelviene, Paulina; Kazlauskas, Evaldas

    2018-06-01

    Adjustment disorder is one of the most diagnosed mental disorders. However, there is a lack of studies of specialized internet-based psychosocial interventions for adjustment disorder. We aimed to analyze the outcomes of an internet-based unguided self-help psychosocial intervention BADI for adjustment disorder in a two armed randomized controlled trial with a waiting list control group. In total 284 adult participants were randomized in this study. We measured adjustment disorder as a primary outcome, and psychological well-being as a secondary outcome at pre-intervention (T1) and one month after the intervention (T2). We found medium effect size of the intervention for the completer sample on adjustment disorder symptoms. Intervention was effective for those participants who used it at least one time in 30-day period. Our results revealed the potential of unguided internet-based self-help intervention for adjustment disorder. However, high dropout rates in the study limits the generalization of the outcomes of the intervention only to completers.

  15. Finite-element modelling and preliminary validation of microneedle-based electrodes for enhanced tissue electroporation.

    Science.gov (United States)

    Houlihan, Ruth; Grygoryev, Konstantin; Zhenfei Ning; Williams, John; Moore, Tom; O'Mahony, Conor

    2017-07-01

    This paper investigates the use of microneedle-based electrodes for enhanced testis electroporation, with specific application to the production of transgenic mice. During the design phase, finite-element software has been used to construct a tissue model and to compare the relative performance of electrodes employing a) conventional flat plates, b) microneedle arrays, and c) invasive needles. Results indicate that microneedle-based electrodes can achieve internal tissue field strengths which are an order of magnitude higher than those generated using conventional flat electrodes, and which are comparable to fields produced using invasive needles. Using a double-sided etching process, conductive microneedle arrays were then fabricated and used in prototype electrodes. In a series of mouse model experiments involving injection of a DNA vector expressing Green Fluorescent Protein (GFP), the performance of flat and microneedle electrodes was compared by measuring GFP expression after electroporation. The main finding, supported by experimental and simulated data, is that use of microneedle-based electrodes significantly enhanced electroporation of testis.

  16. Number of objectives and conclusions in dissertations and thesis

    Directory of Open Access Journals (Sweden)

    Liebano Richard Eloin

    2005-01-01

    Full Text Available PURPOSE: To analyze the number of objectives and conclusions presented in dissertations and thesis defended at Federal University of São Paulo - Paulista School of Medicine (UNIFESP - EPM. METHODS: It was realized a search in the master degree dissertations and doctor degree thesis defended at Federal University of São Paulo - Paulista School of Medicine in the years 2002 and 2003 that were found available in the central library of this university. RESULTS: From 723 master dissertations analyzed, 62 (8,57% presented only one objective and one conclusion, 134 (18,53% presented one objective and more than one conclusion and 527 (72,89% had more than one objective and more than one conclusion. From 502 doctor thesis analyzed, 23 (4,58% presented only one objective and one conclusion, 123 (24,50% presented one objective and more than one conclusion and 376 (74,90% had more than one objective and more than one conclusion.. CONCLUSIONS: It wasn't found in researched literature the number of objectives and conclusions a scientific work must have. A highest number of thesis and dissertations presented more than one objective and more than one conclusion.

  17. The data archive system and preliminary applications of Hefei light source based on oracle

    International Nuclear Information System (INIS)

    Qiang Jie; Liu Gongfa

    2013-01-01

    Data archive system is the key part of HLS control system, it is used for archiving beam parameters, real-time equipment data, alarm records, etc. The Archive Engine of RDB Channel Archiver is used for collecting data from Input Output Controllers of HLS control system and storing in Oracle database. Webpages based on JSP are developed for data inquiry and statistics, with which the data processing and analyzing can be more efficient for operators and researchers. Thus the system can meet the requirements of the HLS machine operation and machine research. (authors)

  18. Theory and Praxis in Community Based Language Development: preliminary findings from applications of the Guide for Planning the Future of Our Language

    OpenAIRE

    Eberhard David M.

    2017-01-01

    This study will provide a critique of preliminary results obtained from the application of the ‘Guide for Planning the Future of Our Language’ (Hanawalt, Varenkamp, Lahn, & Eberhard 2015) in minority speech communities. This recent methodological tool was developed to enable and empower minoritized language groups to do their own language planning and to control their own language development. The tool is based on a theoretical approach to community based language development known as the ‘Su...

  19. Preliminary research on quantitative methods of water resources carrying capacity based on water resources balance sheet

    Science.gov (United States)

    Wang, Yanqiu; Huang, Xiaorong; Gao, Linyun; Guo, Biying; Ma, Kai

    2018-06-01

    Water resources are not only basic natural resources, but also strategic economic resources and ecological control factors. Water resources carrying capacity constrains the sustainable development of regional economy and society. Studies of water resources carrying capacity can provide helpful information about how the socioeconomic system is both supported and restrained by the water resources system. Based on the research of different scholars, major problems in the study of water resources carrying capacity were summarized as follows: the definition of water resources carrying capacity is not yet unified; the methods of carrying capacity quantification based on the definition of inconsistency are poor in operability; the current quantitative research methods of water resources carrying capacity did not fully reflect the principles of sustainable development; it is difficult to quantify the relationship among the water resources, economic society and ecological environment. Therefore, it is necessary to develop a better quantitative evaluation method to determine the regional water resources carrying capacity. This paper proposes a new approach to quantifying water resources carrying capacity (that is, through the compilation of the water resources balance sheet) to get a grasp of the regional water resources depletion and water environmental degradation (as well as regional water resources stock assets and liabilities), figure out the squeeze of socioeconomic activities on the environment, and discuss the quantitative calculation methods and technical route of water resources carrying capacity which are able to embody the substance of sustainable development.

  20. Prediction of 222 Rn exhalation rates from phosphogypsum based stacks. Part II: preliminary numerical results

    International Nuclear Information System (INIS)

    Rabi, Jose A.; Mohamad, Abdulmajeed A.

    2004-01-01

    The first part of this paper proposes a steady-state 2-D model for 222 Rn transport in phosphogypsum stacks. In this second part, the dimensionless model equations are solved numerically with the help of an existing finite-volume simulator that has been successfully used to solve heat and mass transfer problems in porous media. As a test case, a rectangular shaped stack is considered in order to verify the ability of the proposed parametric approach to account for concurrent effects on the 222 Rn exhalation into the local atmosphere. Air flow is supposed to be strictly buoyancy driven and the ground is assumed to be impermeable to 222 Rn and at a higher temperature under the stack base. Dimensionless controlling parameters are set to representative values and results are presented for Grashof number in the range 10 6 ≤Gr≤ 10 8 , corresponding to very small to small temperature differences between incoming air and ground underneath the stack base. For the particular set of parameters and inasmuch as Gr increases, streamlines presented basically the same pattern while internal isotherms and iso concentration lines remained almost unchanged. Total average Sherwood number proved to be rather insensitive to Gr while total average Nusselt increased slightly with Gr. (author)

  1. Knowledge of evidence-based dentistry among academic dental practitioners of Bhopal, India: a preliminary survey

    Directory of Open Access Journals (Sweden)

    Aishwarya Singh

    2015-06-01

    Full Text Available This study aimed to characterize the knowledge of evidence-based dentistry (EBD among dental faculty members in the city of Bhopal in central India. A cross-sectional questionnaire was administered at two dental colleges in Bhopal City. All dental faculty members who were present on the day of the study and who agreed to participate were included in the study. A total of 50 dental faculty members returned the questionnaire. Six Likert-type questions were asked, and the percentages of various responses were used for analysis. Sixteen faculty members (32.0% strongly agreed that EBD is a process of making decisions based on scientifically proven evidence. Fifteen faculty members (30.0% strongly disagreed or disagreed with the item stating that the best and quickest way to find evidence is by reading textbooks or asking experienced colleagues. Thirteen faculty members (26.0% strongly agreed that EBD allows dentists to improve their scientific knowledge and clinical skills. It is recommended that EBD be included in undergraduate and postgraduate curricula and in intensive continuing dental education programs that are conducted for dental faculty members.

  2. A Preliminary Evaluation of a School-Based Media Education and Reduction Intervention.

    Science.gov (United States)

    Bickham, David S; Hswen, Yulin; Slaby, Ronald G; Rich, Michael

    2018-06-01

    While media education and reduction programs have been proposed to prevent adverse health and academic outcomes related to heavy electronic media use among school-aged children, few have been formally piloted and evaluated. We used a quasi-experimental design to evaluate the effectiveness of Take the Challenge (TtC), a school-based media education/reduction program for the primary prevention of sleep deprivation, dysfunctional social-emotional behaviors, and poor academic performance. Sixth- to eighth-grade students at a rural Midwestern U.S. middle school received the TtC program, while a similar school in the same district served as the comparison group. Health-related and academic measures were collected from students and teachers at both schools before and after the intervention. The primary outcome measure was student-reported electronic media use (television, video games, Internet). Secondary measures included student health behaviors (student-reported sleep, exercise, and outdoor play) and academic activities (teacher-reported homework and classroom performance). Compared to the comparison group, students receiving TtC slept more and reduced television viewing, background television time, after-school video gaming, and weekend Internet use. Teachers reported increases in the extent to which TtC students completed homework assignments and stayed on task in the classroom. Well-designed school-based programs such as TtC can reduce electronic media use among middle-school children and improve related health and academic outcomes.

  3. Preliminary Investigation of Time Remaining Display on the Computer-based Emergency Operating Procedure

    Science.gov (United States)

    Suryono, T. J.; Gofuku, A.

    2018-02-01

    One of the important thing in the mitigation of accidents in nuclear power plant accidents is time management. The accidents should be resolved as soon as possible in order to prevent the core melting and the release of radioactive material to the environment. In this case, operators should follow the emergency operating procedure related with the accident, in step by step order and in allowable time. Nowadays, the advanced main control rooms are equipped with computer-based procedures (CBPs) which is make it easier for operators to do their tasks of monitoring and controlling the reactor. However, most of the CBPs do not include the time remaining display feature which informs operators of time available for them to execute procedure steps and warns them if the they reach the time limit. Furthermore, the feature will increase the awareness of operators about their current situation in the procedure. This paper investigates this issue. The simplified of emergency operating procedure (EOP) of steam generator tube rupture (SGTR) accident of PWR plant is applied. In addition, the sequence of actions on each step of the procedure is modelled using multilevel flow modelling (MFM) and influenced propagation rule. The prediction of action time on each step is acquired based on similar case accidents and the Support Vector Regression. The derived time will be processed and then displayed on a CBP user interface.

  4. 3D cinematic rendering of the calvarium, maxillofacial structures, and skull base: preliminary observations.

    Science.gov (United States)

    Rowe, Steven P; Zinreich, S James; Fishman, Elliot K

    2018-06-01

    Three-dimensional (3D) visualizations of volumetric data from CT have gained widespread clinical acceptance and are an important method for evaluating complex anatomy and pathology. Recently, cinematic rendering (CR), a new 3D visualization methodology, has become available. CR utilizes a lighting model that allows for the production of photorealistic images from isotropic voxel data. Given how new this technique is, studies to evaluate its clinical utility and any potential advantages or disadvantages relative to other 3D methods such as volume rendering have yet to be published. In this pictorial review, we provide examples of normal calvarial, maxillofacial, and skull base anatomy and pathological conditions that highlight the potential for CR images to aid in patient evaluation and treatment planning. The highly detailed images and nuanced shadowing that are intrinsic to CR are well suited to the display of the complex anatomy in this region of the body. We look forward to studies with CR that will ascertain the ultimate value of this methodology to evaluate calvarium, maxillofacial, and skull base morphology as well as other complex anatomic structures.

  5. Gulf War Illnesses: DOD's Conclusions about U.S. Troops' Exposure Cannot Be Adequately Supported

    National Research Council Canada - National Science Library

    Rhodes, Keith

    2004-01-01

    ... (MOD) conclusions about troops' exposure. The GAO found that DoD's and MOD's conclusions about troops' exposure to CW agents, based on DoD and CIA plume modeling, cannot be adequately supported...

  6. Individualized computer-aided education in mammography based on user modeling: concept and preliminary experiments.

    Science.gov (United States)

    Mazurowski, Maciej A; Baker, Jay A; Barnhart, Huiman X; Tourassi, Georgia D

    2010-03-01

    The authors propose the framework for an individualized adaptive computer-aided educational system in mammography that is based on user modeling. The underlying hypothesis is that user models can be developed to capture the individual error making patterns of radiologists-in-training. In this pilot study, the authors test the above hypothesis for the task of breast cancer diagnosis in mammograms. The concept of a user model was formalized as the function that relates image features to the likelihood/extent of the diagnostic error made by a radiologist-in-training and therefore to the level of difficulty that a case will pose to the radiologist-in-training (or "user"). Then, machine learning algorithms were implemented to build such user models. Specifically, the authors explored k-nearest neighbor, artificial neural networks, and multiple regression for the task of building the model using observer data collected from ten Radiology residents at Duke University Medical Center for the problem of breast mass diagnosis in mammograms. For each resident, a user-specific model was constructed that predicts the user's expected level of difficulty for each presented case based on two BI-RADS image features. In the experiments, leave-one-out data handling scheme was applied to assign each case to a low-predicted-difficulty or a high-predicted-difficulty group for each resident based on each of the three user models. To evaluate whether the user model is useful in predicting difficulty, the authors performed statistical tests using the generalized estimating equations approach to determine whether the mean actual error is the same or not between the low-predicted-difficulty group and the high-predicted-difficulty group. When the results for all observers were pulled together, the actual errors made by residents were statistically significantly higher for cases in the high-predicted-difficulty group than for cases in the low-predicted-difficulty group for all modeling

  7. Carotid DSA based CFD simulation in assessing the patient with asymptomatic carotid stenosis: a preliminary study.

    Science.gov (United States)

    Zhang, Dong; Xu, Pengcheng; Qiao, Hongyu; Liu, Xin; Luo, Liangping; Huang, Wenhua; Zhang, Heye; Shi, Changzheng

    2018-03-12

    Cerebrovascular events are frequently associated with hemodynamic disturbance caused by internal carotid artery (ICA) stenosis. It is challenging to determine the ischemia-related carotid stenosis during the intervention only using digital subtracted angiography (DSA). Inspired by the performance of well-established FFRct technique in hemodynamic assessment of significant coronary stenosis, we introduced a pressure-based carotid arterial functional assessment (CAFA) index generated from computational fluid dynamic (CFD) simulation in DSA data, and investigated its feasibility in the assessment of hemodynamic disturbance preliminarily using pressure-wired measurement and arterial spin labeling (ASL) MRI as references. The cerebral multi-delay multi-parametric ASL-MRI and carotid DSA including trans-stenotic pressure-wired measurement were implemented on a 65-year-old man with asymptomatic unilateral (left) ICA stenosis. A CFD simulation using simplified boundary condition was performed in DSA data to calculate the CAFA index. The cerebral blood flow (CBF) and arterial transit time (ATT) of ICA territories were acquired. CFD simulation showed good correlation (r = 0.839, P = 0.001) with slight systematic overestimation (mean difference - 0.007, standard deviation 0.017) compared with pressure-wired measurement. No significant difference was observed between them (P = 0.09). Though the narrowing degree of in the involved ICA was about 70%, the simulated and measured CAFA (0.942/0.937) revealed a functionally nonsignificant stenosis which was also verified by a compensatory final CBF (fronto-temporal/fronto-parietal region: 51.58/45.62 ml/100 g/min) and slightly prolonged ATT (1.23/1.4 s) in the involved territories, together with a normal left-right percentage difference (2.1-8.85%). The DSA based CFD simulation showed good consistence with invasive approach and could be used as a cost-saving and efficient way to study the relationship between

  8. Evaluating the potential of multi-purpose nature based solutions in peri-urban landscapes - a preliminary assessment

    Science.gov (United States)

    Geris, Josie; Wilkinson, Mark; Stutter, Marc; Guenther, Daniel; Soulsby, Chris

    2016-04-01

    Many communities across the world face the increasing challenge of balancing water quantity and quality protection and improvement with accommodating new growth and urban development. Urbanisation is typically associated with detrimental changes in water quality, sediment delivery, and effects on water storage and flow pathways (e.g. increases in flooding). Current mitigation solutions are typically based on isolated design strategies used at specific small scale sites and for storm water only. More holistic catchment scale approaches are urgently required to effectively manage the amount of water flows and protect the raw water quality in peri-urban landscapes. This project aims to provide a better understanding of the connectivity between natural and managed flow pathways, storage, and biogeochemical processes in the peri-urban landscape to eventually aid a more integrated water quantity and quality control design. For an actively urbanising catchment in NE Scotland we seek to understand the spatio-temporal character of the natural flow pathways and associated water quality, and how these may be used to support the design of nature based solutions during urbanisation. We present preliminary findings from a dense and multiscale monitoring network that includes hydrometric, tracer (stable water isotopes) and water quality (turbidity (sediment), nitrate, phosphate) data during a range of contrasting hydroclimatological conditions and at different stages of the development of urban infrastructure. These demonstrate a highly variable nature, both temporally and spatially, with water quality dynamics out of sync with storm responses and depending on management practices. This highlights potential difficulties for managing water quantity and quality simultaneously at the catchment scale, and suggests that a treatment train approach may be required. Well-designed nature based solutions that tackle both water quantity and quality issues will require adaptability and a

  9. Preliminary experimental investigation of a natural gas-fired ORC-based micro-CHP system for residential buildings

    International Nuclear Information System (INIS)

    Farrokhi, M.; Noie, S.H.; Akbarzadeh, A.A.

    2014-01-01

    The continual increases in energy demand and greenhouse gas emissions, call for efficient use of energy resources. Decentralized combined heat and power (CHP) technology provides an alternative for the world to meet and solve energy-related problems including energy shortages, energy supply security, emission control and conservation of energy. This paper presents the preliminary results of an experimental investigation of a natural gas-fired micro-CHP system for residential buildings based on an organic Rankine cycle (ORC). Isopentane was used as the ORC working fluid in consideration of several criteria including its environmentally-friendly characteristics. Experiments were conducted to evaluate the performance of the developed system at different heat source temperatures of nominally 85, 80, 75, 70, and 65 °C. The maximum electrical power output of 77.4 W was generated at heating water entry temperature of 84.1 °C, corresponding to net cycle electrical efficiency of 1.66%. Further work will be done with a view to increasing the cycle electrical efficiency by using more efficient components, in particular the expander and generator. - Highlights: •A natural gas-fired ORC-based micro-scale CHP system has been developed and tested. •The good agreement between the mechanical and gross power validates the assumptions. •A vane expander suits a micro-CHP system based on an organic Rankine cycle. •A vane expander does not suit power generation by a Trilateral Flash Cycle (TFC). •Domestic gas-fired ORC systems may reduce reliance on central power stations

  10. Preliminary individualized chemotherapy for malignant astrocytomas based on O6-methylguanine-deoxyribonucleic acid methyltransferase methylation analysis.

    Science.gov (United States)

    Watanabe, Takao; Katayama, Yoichi; Ogino, Akiyoshi; Ohta, Takashi; Yoshino, Atsuo; Fukushima, Takao

    2006-08-01

    O(6)-methylguanine-deoxyribonucleic acid methyltransferase gene (MGMT) methylation is apparently correlated with responsiveness to nitrosourea chemotherapy, suggesting this alkylating agent should be effective against MGMT-methylated tumors. MGMT appears not to be linked to platinum resistance, so platinum chemotherapy should be used for MGMT-unmethylated tumors. This study was a preliminary trial of individualized chemotherapy based on MGMT methylation status in a total of 20 patients with newly diagnosed malignant astrocytomas (9 anaplastic astrocytomas and 11 glioblastomas multiforme). The procarbazine, 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-2(2-chloroethyl)-3-nitrosourea, and vincristine (PAV) regimen was administered to seven patients with MGMT-methylated tumors, and the carboplatin and etoposide (CE) regimen was administered to 13 patients with MGMT-unmethylated tumors. Objective response to the PAV therapy was noted in all three patients with measurable residual tumor (2 complete responses and 1 partial response). Five of the seven patients continued to be disease-free after initiation of the PAV therapy. Objective response to the CE therapy was seen in only one of seven patients with measurable residual tumor (1 partial response). Three of the 13 patients were free from progression, whereas the remaining 10 patients showed early progression. The PAV regimen is effective against MGMT-methylated malignant astrocytomas, but the CE regimen is not useful at the given dose and schedule in MGMT-unmethylated tumors.

  11. Development and preliminary evaluation of a music-based attention assessment for patients with traumatic brain injury.

    Science.gov (United States)

    Jeong, Eunju; Lesiuk, Teresa L

    2011-01-01

    Impairments in attention are commonly seen in individuals with traumatic brain injury (TBI). While visual attention assessment measurements have been rigorously developed and frequently used in cognitive neurorehabilitation, there is a paucity of auditory attention assessment measurements for patients with TBI. The purpose of this study was to field test a researcher-developed Music-based Attention Assessment (MAA), a melodic contour identification test designed to assess three different types of attention (i.e., sustained attention, selective attention, and divided attention), for patients with TBI. Additionally, this study aimed to evaluate the readability and comprehensibility of the test items and to examine the preliminary psychometric properties of the scale and test items. Fifteen patients diagnosed with TBI completed 3 different series of tasks in which they were required to identify melodic contours. The resulting data showed that (a) test items in each of the 3 subtests were found to have an easy to moderate level of item difficulty and an acceptable to high level of item discrimination, and (b) the musical characteristics (i.e., contour, congruence, and pitch interference) were found to be associated with the level of item difficulty, and (c) the internal consistency of the MAA as computed by Cronbach's alpha was .95. Subsequent studies using a larger sample of typical participants, along with individuals with TBI, are needed to confirm construct validity and internal consistency of the MAA. In addition, the authors recommend examination of criterion validity of the MAA as correlated with current neuropsychological attention assessment measurements.

  12. Transoral robotic surgery for the base of tongue squamous cell carcinoma: a preliminary comparison between da Vinci Xi and Si.

    Science.gov (United States)

    Alessandrini, Marco; Pavone, Isabella; Micarelli, Alessandro; Caporale, Claudio

    2017-09-13

    Considering the emerging advantages related to da Vinci Xi robotic platform, the aim of this study is to compare for the first time the operative outcomes of this tool to the previous da Vinci Si during transoral robotic surgery (TORS), both performed for squamous cell carcinomas (SCC) of the base of tongue (BOT). Intra- and peri-operative outcomes of eight patients with early stage (T1-T2) of the BOT carcinoma and undergoing TORS by means of the da Vinci Xi robotic platform (Xi-TORS) are compared with the da Vinci Si group ones (Si-TORS). With respect to Si-TORS group, Xi-TORS group demonstrated a significantly shorter overall operative time, console time, and intraoperative blood loss, as well as peri-operative pain intensity and length of mean hospital stays and nasogastric tube positioning. Considering recent advantages offered by surgical robotic techniques, the da Vinci Xi Surgical System preliminary outcomes could suggest its possible future routine implementation in BOT squamous cell carcinoma procedures.

  13. The Effects of Game-Based Breathing Exercise on Pulmonary Function in Stroke Patients: A Preliminary Study.

    Science.gov (United States)

    Joo, Sunghee; Shin, Doochul; Song, Changho

    2015-06-22

    Reduction of respiratory function along with hemiparesis leads to decreased endurance, dyspnea, and increased sedentary behavior, as well as to an increased risk of stroke. The main purpose of this study was to investigate the preliminary effects of game-based breathing exercise (GBE) on pulmonary function in stroke patients. Thirty-eight in-patients with stroke (22 men, 16 women) were recruited for the study. Participants were randomly allocated into 2 groups: patients assigned to the GBE group (n=19), and the control group (n=19). The GBE group participated in a GBE program for 25 minutes a day, 3 days a week, during a 5 week period. For the same period, both groups participated in a conventional stroke rehabilitation program. Forced vital capacity (FVC), forced expiratory volume at 1 second (FEV1), FEV1/FVC, and maximum voluntary ventilation (MVV) were measured by a spirometer in pre- and post-testing. The GBE group had significantly improved FVC, FEV1, and MVV values compared with the control group (p<0.05), although there was no significant difference in FEV1/FVC value between groups. Significant short-term effects of the GBE program on pulmonary function in stroke patients were recorded in this study. These findings gave some indications that it may be feasible to include GBE in rehabilitation interventions with this population.

  14. A Preliminary Model for Spacecraft Propulsion Performance Analysis Based on Nuclear Gain and Subsystem Mass-Power Balances

    Science.gov (United States)

    Chakrabarti, Suman; Schmidt, George R.; Thio, Y. C.; Hurst, Chantelle M.

    1999-01-01

    A preliminary model for spacecraft propulsion performance analysis based on nuclear gain and subsystem mass-power balances are presented in viewgraph form. For very fast missions with straight-line trajectories, it has been shown that mission trip time is proportional to the cube root of alpha. Analysis of spacecraft power systems via a power balance and examination of gain vs. mass-power ratio has shown: 1) A minimum gain is needed to have enough power for thruster and driver operation; and 2) Increases in gain result in decreases in overall mass-power ratio, which in turn leads to greater achievable accelerations. However, subsystem mass-power ratios and efficiencies are crucial: less efficient values for these can partially offset the effect of nuclear gain. Therefore, it is of interest to monitor the progress of gain-limited subsystem technologies and it is also possible that power-limited systems with sufficiently low alpha may be competitive for such ambitious missions. Topics include Space flight requirements; Spacecraft energy gain; Control theory for performance; Mission assumptions; Round trips: Time and distance; Trip times; Vehicle acceleration; and Minimizing trip times.

  15. Preliminary design study of pebble bed reactor HTR-PM base using once-through-then-out fuel recirculation

    International Nuclear Information System (INIS)

    Topan Setiadipura; Jupiter S Pane; Zuhair

    2016-01-01

    Pebble Bed Reactor (PBR) is one of the advanced reactor type implementing strong passive safety feature. In this type of design has the potential to do a cogeneration useful for the treatment of various minerals in various islands in Indonesia. The operation of the PBR can be simplified by implementing once-through-then-out (OTTO) fuel recirculation scheme in which pebble fuel only pass the core once time. The purpose of this research is to understand quantitative influence of the changing of fuel element recirculation on the PBR core performance and to find preliminary optimization design of PBR type reactor with OTTO recirculation scheme. PEBBED software was used to find PBR equilibrium core. The calculation result gives quantitative data on the impact of implementing a different fuel recirculation, especially using OTTO scheme. Furthermore, an early optimized PBR design based on HTR-PM using OTTO scheme was obtained where the power must be downgraded into 115 MWt in order to preserve the safety feature. The simplicity of the reactor operation and the reduction of reactor component with OTTO scheme still make this early optimized design an interesting alternative design, despite its power reduction from the reference design. (author)

  16. A preliminary assessment of financial stability, efficiency, health systems and health outcomes using performance-based contracts in Belize.

    Science.gov (United States)

    Bowser, Diana M; Figueroa, Ramon; Natiq, Laila; Okunogbe, Adeyemi

    2013-01-01

    Over the last 10 years, Belize has implemented a National Health Insurance (NHI) program that uses performance-based contracts with both public and private facilities to improve financial sustainability, efficiency and service provision. Data were collected at the facility, district and national levels in order to assess trends in financial sustainability, efficiency payments, year-end bonuses and health system and health outcomes. A difference-in-difference approach was used to assess the difference in technical efficiency between private and public facilities. The results show that per capita spending on services provided by the NHI program has decreased over the period 2006-2009 from BZ$177 to BZ$136. The private sector has achieved higher levels of technical efficiency, but lower percentages of efficiency and year-end bonus payments. Districts with contracts through the NHI program showed greater improvements in facility births, nurse density, reducing maternal mortality, diabetes deaths and morbidity from bronchitis, emphysema and asthma than districts without contracts over the period 2006-2010. This preliminary assessment of Belize's pay-for-performance system provides some positive results, however further research is needed to use the lessons learned from Belize to implement similar reforms in other systems.

  17. The Resilience Program: Preliminary evaluation of a mentalization-based education program.

    Directory of Open Access Journals (Sweden)

    Poul Lundgaard Bak

    2015-06-01

    Full Text Available In order to manage with the burden of mental health problems in the world we need to develop cost-effective and safe preventive interventions. Education about resilience to support the ability to cope with life challenges in general, may be a useful strategy. We consider the concepts of Theory of Mind and Mentalization to be relevant in this context. In this paper we describe a simple modular intervention program based on these concepts which can be tailored to specific needs and situations in individual therapy as well as group levels. The program has shown promising results in pilot studies and is now tested in controlled trials in settings such as schools and educational institutions, adults diagnosed with ADHD and children in foster care.

  18. Preliminary Results from Duplex Procedure for Obtain of Fe Based Materials for Automotive Applications

    Science.gov (United States)

    Crăciun, R. C.; Stanciu, S.; Geantă, V.; Voiculescu, I.; Manole, V.; Gârneţ, I. A.; Alexandru, A.; Cimpoesu, N.; Săndulache, F.

    2017-06-01

    Abstract Iron based materials still represent a high percentage from metallic materials used in industry, in general, and in automotive industry, in particular. In this case we used a duplex process in order to obtain the FeMnSiAl experimental alloy for a more efficient use of various units. In the first stage iron, manganese, silicon and aluminum were melted and mixed together using arc melting technology and for the second stage the alloy was re-melt for homogeneity in an induction furnace. Chemical composition, after each melting step, was analyzed using EDS Bruker detector for various areas and microstructural characterization using SEM, VegaTescan LMH II with SE detector, equipment. This alloy is proposed as a metallic approach of mechanical dumpers used in automotive industry for low and medium impact contacts.

  19. Preliminary In-vivo Results For Spatially Coded Synthetic Transmit Aperture Ultrasound Based On Frequency Division

    DEFF Research Database (Denmark)

    Gran, Fredrik; Hansen, Kristoffer Lindskov; Jensen, Jørgen Arendt

    2006-01-01

    This paper investigates the possibility of using spatial coding based on frequency division for in-vivo synthetic transmit aperture (STA) ultrasound imaging. When using spatial encoding for STA, it is possible to use several transmitters simultaneously and separate the signals at the receiver....... This increases the maximum transmit power compared to conventional STA, where only one transmitter can be active. The signal-to-noise-ratio can therefore he increased and better penetration can be obtained. For frequency division, the coding is achieved by designing a number of transmit waveforms with disjoint...... spectral support, spanning the passband of the ultrasound transducer. The signals can therefore he separated at the receiver using matched filtering. The method is tested using a commercial linear array transducer with a center frequency of 9 MHz and 68% fractional bandwidth. In this paper, the transmit...

  20. Preliminary Test of Upgraded Conventional Milling Machine into PC Based CNC Milling Machine

    International Nuclear Information System (INIS)

    Abdul Hafid

    2008-01-01

    CNC (Computerized Numerical Control) milling machine yields a challenge to make an innovation in the field of machining. With an action job is machining quality equivalent to CNC milling machine, the conventional milling machine ability was improved to be based on PC CNC milling machine. Mechanically and instrumentally change. As a control replacing was conducted by servo drive and proximity were used. Computer programme was constructed to give instruction into milling machine. The program structure of consists GUI model and ladder diagram. Program was put on programming systems called RTX software. The result of up-grade is computer programming and CNC instruction job. The result was beginning step and it will be continued in next time. With upgrading ability milling machine becomes user can be done safe and optimal from accident risk. By improving performance of milling machine, the user will be more working optimal and safely against accident risk. (author)

  1. Preliminary assessment of water-based nano-fluids for use as coolants in PWRs

    International Nuclear Information System (INIS)

    Jacopo Buongiorno

    2005-01-01

    Full text of publication follows: The impact of using water-based fluids with small additions (<2% vol.) of nano-sized (10-100 nm) particle populations as coolants for current and advanced PWRs is evaluated. Such 'engineered' fluids (known as nano-fluids) are attractive because the presence of the nano-particles enhances energy transport considerably. As a result, nano-fluids are known to have (i) higher thermal conductivity than water (up to 20% depending on nano-particle material, size and volumetric fraction), (ii) higher heat transfer coefficients (up to 40%), (iii) higher CHF (up to 300% in pool boiling), and (iv) comparable pressure drop. Furthermore, nano-fluids appear to be very stable suspensions with little or no sedimentation, because of the small size of the dispersed particles and their typically low volumetric fractions. The ultimate objective of this work is to assess whether existing PWRs could be retro-fitted with a water-based nano-fluid coolant, to increase safety margins, reduce stored energy, and/or allow for power up-rates. Also, advanced PWRs could be designed with nano-fluids. The linear heat generation rate in PWRs is limited by a) fuel centerline melting, b) cladding overheating (CHF), and c) stored energy release following a large-break LOCA. Mechanisms b) and c) are usually the most limiting. For given geometry and linear power, it is obvious that the core with the nano-fluid coolant will have higher margins to CHF and LOCA limits. Conversely, for given margins, a higher linear power can be accommodated by the nano-fluid-cooled core. Standard thermal-hydraulic models for the PWR hot fuel pin (including a RELAP model for the LOCA) have been used to quantify the benefit of using nano-fluid coolants on the performance of a PWR. (author)

  2. Open innovation: A preliminary model from the Knowledge-based Theory

    Directory of Open Access Journals (Sweden)

    Rocío González-Sánchez

    2011-04-01

    Full Text Available Purpose: The open innovation paradigm is an alternative and/or complementary way to knowledge management processes in its various stages, questioning the basic assumptions where some of the technological innovation strategies and processes are based on. The new logic of innovation process exploits knowledge dissemination through new innovation communities, on the one hand, and, considers of strategic value the external access to intangible resources. Thus, this approach supposes an alternative view to the traditional close innovation, focused on the exclusive exploitation of value innovations. This paper aims to contribute to building an integrated model of key factors to success in open innovation processes. It is analyzed for the role that certain key knowledge management decisions have on the results of open innovation projects, to facilitate the change process and provide new capacity or skills to do so. Design/methodology/approach: Through the review of theoretical and empirical literature, we show the main variables related to the functioning of open innovation systems, and establish various propositions about the meaning and intensity of such relationships.Findings: The management of open innovation project improves through three external factors: technical leadership based on experience, the intensive use of ICT, which allows a multilateral communication, and the existence of intermediate agents or facilitators with a strong neutral attitude. The results also depend on internal factors: the link function, the search routines, the establishment of incentive systems to encourage proactivity and organizational culture.Originality/value: In the absence of full proposals to guide effective decision making on both the management of relationships between organizations, as well as factors inherent to each of them, this paper proposes an exploratory model that integrates the key success factors in open innovation processes.

  3. Design and development of a linked open data-based health information representation and visualization system: potentials and preliminary evaluation.

    Science.gov (United States)

    Tilahun, Binyam; Kauppinen, Tomi; Keßler, Carsten; Fritz, Fleur

    2014-10-25

    Healthcare organizations around the world are challenged by pressures to reduce cost, improve coordination and outcome, and provide more with less. This requires effective planning and evidence-based practice by generating important information from available data. Thus, flexible and user-friendly ways to represent, query, and visualize health data becomes increasingly important. International organizations such as the World Health Organization (WHO) regularly publish vital data on priority health topics that can be utilized for public health policy and health service development. However, the data in most portals is displayed in either Excel or PDF formats, which makes information discovery and reuse difficult. Linked Open Data (LOD)-a new Semantic Web set of best practice of standards to publish and link heterogeneous data-can be applied to the representation and management of public level health data to alleviate such challenges. However, the technologies behind building LOD systems and their effectiveness for health data are yet to be assessed. The objective of this study is to evaluate whether Linked Data technologies are potential options for health information representation, visualization, and retrieval systems development and to identify the available tools and methodologies to build Linked Data-based health information systems. We used the Resource Description Framework (RDF) for data representation, Fuseki triple store for data storage, and Sgvizler for information visualization. Additionally, we integrated SPARQL query interface for interacting with the data. We primarily use the WHO health observatory dataset to test the system. All the data were represented using RDF and interlinked with other related datasets on the Web of Data using Silk-a link discovery framework for Web of Data. A preliminary usability assessment was conducted following the System Usability Scale (SUS) method. We developed an LOD-based health information representation, querying

  4. Preliminary neutronic assessment for ATF (Accident Tolerant Fuel) based on iron alloy

    International Nuclear Information System (INIS)

    Abe, Alfredo; Carluccio, Thiago; Piovezan, Pamela; Giovedi, Claudia; Martins, Marcelo R.

    2015-01-01

    After Fukushima Daiichi nuclear accident in 2011, the nuclear fuel performance under accident condition became a very important issue and currently different research and development program are in progress toward to reliability and withstand under accident condition. These initiatives are known as ATF (Accident Tolerant Fuel) R and D program, which many countries with different research institutes, fuel vendors and others are nowadays involved. Accident Tolerant Fuel (ATF) can be defined as enhanced fuel which can tolerate loss of active cooling system capability for a considerably longer time period and the fuel/cladding system can be maintained without significant degradation and can also improve the fuel performance during normal operations and transients, as well as design-basis accident (DBA) and beyond design-basis (BDBA) accident. Different materials have being proposed as fuel cladding candidates considering thermo-mechanical properties and lower reaction kinetic with steam and slower hydrogen production. The aim of this work is to perform a neutronic assessment for several cladding candidates based on iron alloy considering a standard PWR fuel rod (fuel pellet and dimension). The purpose of the assessment is to address different parameters that might contribute for possible neutronic reactivity gain in order to overcome the penalty due to increase of neutron absorption in the cladding materials. All the neutronic assessment is performed using MCNP, Monte Carlo code. (author)

  5. Performance, cost and environmental assessment of gasification-based electricity in India: A preliminary analysis

    Science.gov (United States)

    Rani, Abha; Singh, Udayan; Jayant; Singh, Ajay K.; Sankar Mahapatra, Siba

    2017-07-01

    Coal gasification processes are crucial to decarbonisation in the power sector. While underground coal gasification (UCG) and integrated gasification combined cycle (IGCC) are different in terms of the site of gasification, they have considerable similarities in terms of the types of gasifiers used. Of course, UCG offers some additional advantages such as reduction of the fugitive methane emissions accompanying the coal mining process. Nevertheless, simulation of IGCC plants involving surface coal gasification is likely to give reasonable indication of the 3E (efficiency, economics and emissions) prospects of the gasification pathway towards electricity. This paper will aim at Estimating 3E impacts (efficiency, environment, economics) of gasification processes using simulation carried out in the Integrated Environmental Control Model (IECM) software framework. Key plant level controls which will be studied in this paper will be based on Indian financial regulations and operating costs which are specific to the country. Also, impacts of CO2 capture and storage (CCS) in these plants will be studied. The various parameters that can be studied are plant load factor, impact of coal quality and price, type of CO2 capture process, capital costs etc. It is hoped that relevant insights into electricity generation from gasification may be obtained with this paper.

  6. Combining semantic technologies with a content-based image retrieval system - Preliminary considerations

    Science.gov (United States)

    Chmiel, P.; Ganzha, M.; Jaworska, T.; Paprzycki, M.

    2017-10-01

    Nowadays, as a part of systematic growth of volume, and variety, of information that can be found on the Internet, we observe also dramatic increase in sizes of available image collections. There are many ways to help users browsing / selecting images of interest. One of popular approaches are Content-Based Image Retrieval (CBIR) systems, which allow users to search for images that match their interests, expressed in the form of images (query by example). However, we believe that image search and retrieval could take advantage of semantic technologies. We have decided to test this hypothesis. Specifically, on the basis of knowledge captured in the CBIR, we have developed a domain ontology of residential real estate (detached houses, in particular). This allows us to semantically represent each image (and its constitutive architectural elements) represented within the CBIR. The proposed ontology was extended to capture not only the elements resulting from image segmentation, but also "spatial relations" between them. As a result, a new approach to querying the image database (semantic querying) has materialized, thus extending capabilities of the developed system.

  7. Home-based humidification for mucositis in patients undergoing radical radiotherapy: preliminary report.

    Science.gov (United States)

    Morton, Randall P; Thomson, Vicki C; Macann, Andrew; Gerard, Catherine M; Izzard, Mark; Hay, K David

    2008-04-01

    Oropharyngeal mucositis is a frequent, severe complication of local irradiation for tumours in the head and neck. We postulated that heated humidification of inspired air via a nasal interface may palliate symptoms of mucositis by reducing the discomfort associated with dry, sticky secretions. We sought to review the effect of home-based humidification on hospital admissions and the patient reported experience of that humidification. This study was a retrospective review. A historical (control) group of patients did not receive home humidification at any stage (n = 55) and a study group (n = 53) received home humidification at or after the onset of grade 3 mucositis. A questionnaire was sent to study group patients to obtain information about their experience of using the humidifier at home. There were no demographic differences between the study and control groups, but the study group had significantly more advanced cancer (stage IV; p = .0307) and significantly higher total fractions and days treated (p humidification were admitted after starting that use (p humidification was of benefit, and 81% stated that it relieved mouth or throat pain. Humidification of inspired gas offers a simple, drug-free option for managing a number of the adverse mucosal effects of radiation and chemoradiation in head and neck cancer patients.

  8. A Preliminary Test for Skin Gas Assessment Using a Porphyrin Based Evanescent Wave Optical Fiber Sensor

    Directory of Open Access Journals (Sweden)

    Roman SELYANCHYN

    2011-02-01

    Full Text Available An evanescent-wave optical fibre sensor modified with tetrakis-(4-sulfophenyl porphine (TSPP and poly(allylamine hydrochloride (PAH bilayers using layer-by-layer (LbL electrostatic self-assembly was tested to measure the gas emitted from human skin. Optical intensity changes at different wavelengths in the transmission spectrum of the porphyrin-based film were induced by the human skin gas and measured as sensor response. Influence of relative humidity, which can be a major interference to sensor response, was thoroughly studied and shown to be significantly different when compared to the influence of skin emanations. Responses of the current optical sensor system could be considered as composite sensor array, where different optical wavelengths act as channels that have selective response to specific volatile compounds. Data obtained from the sensor system was analyzed using principal component analysis (PCA. This approach enabled to distinguish skin odors of different people and their altered physiological conditions after alcohol consumption.

  9. Antisocial and Schizoid Personality Disorder Scales: Conceptual bases and preliminary findings

    Directory of Open Access Journals (Sweden)

    Octav - Sorin Căndel

    2017-06-01

    Full Text Available The study describes the development and validation of two scales which can be used in evaluating schizoid and antisocial personality disorders. Both scales were developed relying on descriptions from DSM 5 and ICD 10. For validation, the scales have been tested on 125 subjects, together with two well-known psychometric instruments, DA12profile Personality Inventory, and SCL-90. Internal consistency is calculated using Cronbach's alpha coefficient. Schizoid Scale contains 20 items and shows a good internal consistency (Cronbach's α = .77 and Antisocial Scale contains 22 items and has excellent internal consistency (Cronbach's α = .91. The correlations between the scores of the two scales and the scores of DA12profile Personality Inventory and SCL-90 are statistically significant. The factorial analysis reveals that the two scales and DA12profile Personality Inventory sub-scales are clustered in four factors, explaining 68.31 % of the variance. Based on these results, we discussed the importance the scales have for psychological research and for psycho-diagnostic, their limitations and our future directions of research.

  10. ROSFOND based heating-damage cross sections sub-library: Preliminary uncertainty assessment

    International Nuclear Information System (INIS)

    Sinitsa, V.V.

    2016-01-01

    The accuracy of radiation damage calculations for the most important LWR component, the reactor pressure vessel (RPV), directly linked with the RPV End-of-Life (EoL) prediction which is in its turn connected with fundamental nuclear safety aspects and relevant economic impacts. In this connection, for nearly ten years the ENEA-Bologna Nuclear Data Group conducts the nuclear data processing and validation activities addressed to update the specialized broad-group coupled neutron/photon working cross section libraries for shielding and radiation damage calculations through NJOY and Bologna revised version of SCAMPI data processing systems. A number of working group-wise data libraries has been prepared and transferred to the ENEA Data Bank for dissemination. Several years ago the NRC ”Kurchatov Institute” has reset the GRUCON project, originally designed to provide group constants for fast nuclear reactor calculations [12], with aim to expand its application area and to use in the WWER safety tasks, in particular, in the RPV radiation damage analyses. By means of updated GRUCON and NJOY-99 processing codes, and calculation procedure, developed in the NDG of ENEA Bologna, a sample of kerma&damage energy point-wise data sub-libraries from different evaluated data libraries has been generated. On the base of this sample, the quantitative assessment of kerma/dpa data precision in the RPV calculations is obtained

  11. Preliminary Investigation of an SOI-based Arrayed Waveguide Grating Demodulation Integration Microsystem

    Science.gov (United States)

    Li, Hongqiang; Zhou, Wenqian; Liu, Yu; Dong, Xiaye; Zhang, Cheng; Miao, Changyun; Zhang, Meiling; Li, Enbang; Tang, Chunxiao

    2014-05-01

    An arrayed waveguide grating (AWG) demodulation integration microsystem is investigated in this study. The system consists of a C-band on-chip LED, a 2 × 2 silicon nanowire-based coupler, a fiber Bragg grating (FBG) array, a 1 × 8 AWG, and a photoelectric detector array. The coupler and AWG are made from silicon-on-insulator wafers using electron beam exposure and response-coupled plasma technology. Experimental results show that the excess loss in the MMI coupler with a footprint of 6 × 100 μm2 is 0.5423 dB. The 1 × 8 AWG with a footprint of 267 × 381 μm2 and a waveguide width of 0.4 μm exhibits a central channel loss of -3.18 dB, insertion loss non-uniformity of -1.34 dB, and crosstalk level of -23.1 dB. The entire system is preliminarily tested. Wavelength measurement precision is observed to reach 0.001 nm. The wavelength sensitivity of each FBG is between 0.04 and 0.06 nm/dB.

  12. Case based reasoning applied to medical diagnosis using multi-class classifier: A preliminary study

    Directory of Open Access Journals (Sweden)

    D. Viveros-Melo

    2017-02-01

    Full Text Available Case-based reasoning (CBR is a process used for computer processing that tries to mimic the behavior of a human expert in making decisions regarding a subject and learn from the experience of past cases. CBR has demonstrated to be appropriate for working with unstructured domains data or difficult knowledge acquisition situations, such as medical diagnosis, where it is possible to identify diseases such as: cancer diagnosis, epilepsy prediction and appendicitis diagnosis. Some of the trends that may be developed for CBR in the health science are oriented to reduce the number of features in highly dimensional data. An important contribution may be the estimation of probabilities of belonging to each class for new cases. In this paper, in order to adequately represent the database and to avoid the inconveniences caused by the high dimensionality, noise and redundancy, a number of algorithms are used in the preprocessing stage for performing both variable selection and dimension reduction procedures. Also, a comparison of the performance of some representative multi-class classifiers is carried out to identify the most effective one to include within a CBR scheme. Particularly, four classification techniques and two reduction techniques are employed to make a comparative study of multiclass classifiers on CBR

  13. Mindfulness Based Functional Therapy: A preliminary open trial of an integrated model of care for people with persistent low back pain.

    Directory of Open Access Journals (Sweden)

    Robert eSchutze

    2014-08-01

    Full Text Available Objectives: This pilot study investigated the feasibility and clinical utility of implementing a novel, evidence-informed, interdisciplinary group intervention – Mindfulness Based Functional Therapy (MBFT – for the management of persistent low back pain (LBP in primary care. MBFT aimed to improve physical and psychological functioning in patients with persistent LBP. Design: A single-group repeated measures design was utilized to gather data about feasibility, effect sizes, clinically significant changes and patient satisfaction.Setting: A community sample of 16 adults (75% female, mean (SD age 47.00 (9.12 years (range 26-65 years, with mean (SD LBP duration of 8.00 (9.00 years participated, using a simulated primary care setting at Curtin University in Australia.Intervention: MBFT is an 8-week group intervention co-facilitated by psychology and physiotherapy disciplines. Content includes: mindfulness meditation training, cognitive-functional physiotherapeutic movement retraining, pain education, and group support.Main outcome measures: Several validated self-report measures were used to assess functional disability, emotional functioning, mindfulness, pain catastrophizing, health-related quality of life at baseline, post-intervention, and 6 months follow-up.Results: Adherence and satisfaction was high, with 85% of participants highly satisfied with MBFT. Clinical significance analysis and effect size estimates showed improvements in a number of variables, including pain catastrophizing, physical functioning, role limitations due to physical condition, and depression, although these may have occurred due to non-intervention effects. Conclusions: MBFT is feasible to implement in primary care. Preliminary findings suggest that a randomized controlled trial is warranted to investigate its efficacy in improving physical and emotional functioning in people with disabling persistent LBP.

  14. Mammography-based screening program: preliminary results from a first 2-year round in a Brazilian region using mobile and fixed units

    Directory of Open Access Journals (Sweden)

    Haikel Raphael

    2012-10-01

    Full Text Available Abstract Background Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer deaths among women worldwide. The use of mobile mammography units to offer screening to women living in remote areas is a rational strategy to increase the number of women examined. This study aimed to evaluate results from the first 2 years of a government-organized mammography screening program implemented with a mobile unit (MU and a fixed unit (FU in a rural county in Brazil. The program offered breast cancer screening to women living in Barretos and the surrounding area. Methods Based on epidemiologic data, 54 238 women, aged 40 to 69 years, were eligible for breast cancer screening. The study included women examined from April 1, 2003 to March 31, 2005. The chi-square test and Bonferroni correction analyses were used to evaluate the frequencies of tumors and the importance of clinical parameters and tumor characteristics. Significance was set at p Results Overall, 17 964 women underwent mammography. This represented 33.1% of eligible women in the area. A mean of 18.6 and 26.3 women per day were examined in the FU and MU, respectively. Seventy six patients were diagnosed with breast cancer (41 (54% in the MU. This represented 4.2 cases of breast cancer per 1000 examinations. The number of cancers detected was significantly higher in women aged 60 to 69 years than in those aged 50 to 59 years (p Conclusions Preliminary results indicate that this mammography screening program is feasible for implementation in a rural Brazilian territory and favor program continuation.

  15. α-Tocopherol/chitosan-based nanoparticles: characterization and preliminary investigations for emulsion systems application

    Science.gov (United States)

    Aresta, Antonella; Calvano, Cosima Damiana; Trapani, Adriana; Zambonin, Carlo Giorgio; De Giglio, Elvira

    2014-02-01

    The processes of lipids oxidation represent a great concern for the consumer health because they are one of the major causes of quality deterioration in fat-containing products. One of the most effective methods of delaying lipid oxidation consists in incorporating antioxidants. The present investigation describes the formulation of chitosan and novel glycol chitosan nanoparticles (NPs) loaded with α-Tocopherol (αToc-NPs). The obtained NPs were characterized by various techniques, such as particle size (showing mean diameters in the range 335-503 nm) and zeta potential measurements, X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy. The NPs were, then, added in the preparation of oil-in-water simple emulsion both to make the lipophilic αToc available in an aqueous medium and to prevent emulsion oxidation. For this purpose, a new highly sensitive, simple and solvent-free method based on a solid phase microextraction (SPME) coupled to gas chromatography mass spectrometry was developed for the determination of αToc in aqueous medium. All the parameters influencing SPME, including fiber coating, time and temperature extraction, pH, ionic strength and desorption conditions, have been carefully screened. The method was successfully applied to the determination of vitamin in the αToc-NPs and its release from NPs-enriched simple emulsion formulations. SPME provided high recovery yields and the limits of detection and of quantification in emulsion were 0.1 and 0.5 μg/mg, respectively. The precision of the method has been also estimated. The delay of the lipid oxidation by the proposed formulations has been evaluated exploiting the Kreis test on αToc-NPs-enriched emulsions.

  16. Apology in cases of medical error disclosure: Thoughts based on a preliminary study.

    Science.gov (United States)

    Dahan, Sonia; Ducard, Dominique; Caeymaex, Laurence

    2017-01-01

    Disclosing medical errors is considered necessary by patients, ethicists, and health care professionals. Literature insists on the framing of this disclosure and describes the apology as appropriate and necessary. However, this policy seems difficult to put into practice. Few works have explored the function and meaning of the apology. The aim of this study was to explore the role ascribed to apology in communication between healthcare professionals and patients when disclosing a medical error, and to discuss these findings using a linguistic and philosophical perspective. Qualitative exploratory study, based on face-to-face semi-structured interviews, with seven physicians in a neonatal unit in France. Discourse analysis. Four themes emerged. Difference between apology in everyday life and in the medical encounter; place of the apology in the process of disclosure together with explanations, regrets, empathy and ways to avoid repeating the error; effects of the apology were to allow the patient-physician relationship undermined by the error, to be maintained, responsibility to be accepted, the first steps towards forgiveness to be taken, and a less hierarchical doctor-patient relationship to be created; ways of expressing apology ("I am sorry") reflected regrets and empathy more than an explicit apology. This study highlights how the act of apology can be seen as a "language act" as described by philosophers Austin and Searle, and how it functions as a technique for making amends following a wrongdoing and as an action undertaken in order that neither party should lose face, thus echoing the sociologist Goffmann's interaction theory. This interpretation also accords with the views of Lazare, for whom the function of apology is a restoration of dignity after the humiliation of the error. This approach to the apology illustrates how meaning and impact of real-life language acts can be clarified by philosophical and sociological ideas.

  17. Transcutaneous electrical nerve stimulation and transcutaneous spinal electroanalgesia: a preliminary efficacy and mechanisms-based investigation.

    Science.gov (United States)

    Palmer, Shea; Cramp, Fiona; Propert, Kate; Godfrey, Helen

    2009-09-01

    To determine the effects of transcutaneous electrical nerve stimulation (TENS) and transcutaneous spinal electroanalgesia (TSE) on mechanical pain threshold (MPT) and vibration threshold (VT). A prospective, single-blind, randomised, placebo-controlled trial. Laboratory based. Thirty-four healthy volunteers (12 men and 22 women; mean age+/-standard deviation 30+/-8 years). Exclusion criteria were conditions affecting upper limb sensation and contraindications to electrical stimulation. Participants were allocated at random to receive TENS (n=8), TSE (n=8), placebo (n=9) or control (n=9). Electrical stimulation was applied for 30 minutes (from time 18 minutes to 48 minutes) via electrodes (5 cmx5 cm) placed centrally above and below the space between the C6 and C7 spinous processes, with 5 cm between electrodes. MPT (using an algometer) and VT (using a vibrameter) were recorded on seven occasions from the first dorsal interosseous muscle of the right hand - at baseline (0 minutes) and then at 10-minute intervals until the end of the 60-minute testing period. There were no statistically significant group differences in MPT (all p>0.05). Significant group differences in VT were found at 20, 30 and 40 minutes (all ptests showed that the TENS group had significantly greater VT than both the placebo [median difference 0.30 microm, 95% confidence interval (CI) -0.05 to 0.66] and control (0.51 microm, 95% CI 0.05 to 0.97) groups at 20 minutes, and significantly greater VT than the control group (0.69 microm, 95% CI 0.20 to 1.17) at 30 minutes (all p<0.008). Electrical stimulation did not alter MPT. The increase in VT during TENS may be due to distraction or antidromic block of large-diameter nerve fibres. TSE failed to alter either outcome measure significantly.

  18. A preliminary global geologic map of Vesta based on Dawn Survey orbit data

    Science.gov (United States)

    Yingst, R.; Williams, D. A.; Garry, W. B.; Mest, S. C.; Petro, N. E.; Buczkowski, D.; Schenk, P.; Jaumann, R.; Pieters, C. M.; Roatsch, T.; Preusker, F.; Nathues, A.; LeCorre, L.; Reddy, V.; Russell, C. T.; Raymond, C. A.; DeSanctis, C.; Ammannito, E.; Filacchione, G.

    2011-12-01

    NASA's Dawn spacecraft arrived at the asteroid 4Vesta on July 15, 2011, and is now collecting imaging, spectroscopic, and elemental abundance data during its one-year orbital mission. As part of the geological analysis of the surface, we have utilized images and data from the Survey orbital sequence to produce a global map of Vesta's surface. Unit boundaries and feature characteristics were determined primarily from morphologic analysis of image data; projected Framing Camera (FC) images were used as the base map. Spectral information from FC and VIR are used to refine unit contacts and to separate compositional distinctions from differences arising from illumination or other factors. Those units that could be discerned both in morphology and in the color data were interpreted as geologically distinct units. Vesta's surface is highly-cratered; differences in color and albedo are possible indicators of varying thicknesses and areal extents of crater ejecta. The most prominent candidate impact feature dominates the south pole. This feature consists of a depression roughly circular in shape, with a central hill that is characterized by smoother texture and lower albedo distinctive from the lower-lying surrounding terrain. A complex network of deep troughs and ridges cuts through the floor of the feature. Many of these troughs trend north-south, while others appear circumferential to the hill and are truncated by or terminate at orthogonal ridges/grooves. Detailed mapping of these features will provide information on their orientations, possible origin(s), and their relationship, if any, to the central hill. The equator of Vesta is also girdled by a wide set of flat-floored troughs. Their orientation implies that their formation is related to the south polar structure. Several regions on Vesta have a concentration of craters displaying low-albedo interiors or exteriors. These craters may have an exogenic origin, or may be the result of excavation of a thin sub

  19. The Use of Statistically Based Rolling Supply Curves for Electricity Market Analysis: A Preliminary Look

    Energy Technology Data Exchange (ETDEWEB)

    Jenkin, Thomas J [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Larson, Andrew [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Ruth, Mark F [National Renewable Energy Laboratory (NREL), Golden, CO (United States); King, Ben [U.S. Department of Energy; Spitsen, Paul [U.S. Department of Energy

    2018-03-27

    In light of the changing electricity resource mixes across the United States, an important question in electricity modeling is how additions and retirements of generation, including additions in variable renewable energy (VRE) generation could impact markets by changing hourly wholesale energy prices. Instead of using resource-intensive production cost models (PCMs) or building and using simple generator supply curves, this analysis uses a 'top-down' approach based on regression analysis of hourly historical energy and load data to estimate the impact of supply changes on wholesale electricity prices, provided the changes are not so substantial that they fundamentally alter the market and dispatch-order driven behavior of non-retiring units. The rolling supply curve (RSC) method used in this report estimates the shape of the supply curve that fits historical hourly price and load data for given time intervals, such as two-weeks, and then repeats this on a rolling basis through the year. These supply curves can then be modified on an hourly basis to reflect the impact of generation retirements or additions, including VRE and then reapplied to the same load data to estimate the change in hourly electricity price. The choice of duration over which these RSCs are estimated has a significant impact on goodness of fit. For example, in PJM in 2015, moving from fitting one curve per year to 26 rolling two-week supply curves improves the standard error of the regression from 16 dollars/MWh to 6 dollars/MWh and the R-squared of the estimate from 0.48 to 0.76. We illustrate the potential use and value of the RSC method by estimating wholesale price effects under various generator retirement and addition scenarios, and we discuss potential limits of the technique, some of which are inherent. The ability to do this type of analysis is important to a wide range of market participants and other stakeholders, and it may have a role in complementing use of or providing

  20. Image-guided, intensity-modulated radiation therapy (IG-IMRT) for skull base chordoma and chondrosarcoma: preliminary outcomes.

    Science.gov (United States)

    Sahgal, Arjun; Chan, Michael W; Atenafu, Eshetu G; Masson-Cote, Laurence; Bahl, Gaurav; Yu, Eugene; Millar, Barbara-Ann; Chung, Caroline; Catton, Charles; O'Sullivan, Brian; Irish, Jonathan C; Gilbert, Ralph; Zadeh, Gelareh; Cusimano, Michael; Gentili, Fred; Laperriere, Normand J

    2015-06-01

    We report our preliminary outcomes following high-dose image-guided intensity modulated radiotherapy (IG-IMRT) for skull base chordoma and chondrosarcoma. Forty-two consecutive IG-IMRT patients, with either skull base chordoma (n = 24) or chondrosarcoma (n = 18) treated between August 2001 and December 2012 were reviewed. The median follow-up was 36 months (range, 3-90 mo) in the chordoma cohort, and 67 months (range, 15-125) in the chondrosarcoma cohort. Initial surgery included biopsy (7% of patients), subtotal resection (57% of patients), and gross total resection (36% of patients). The median IG-IMRT total doses in the chondrosarcoma and chordoma cohorts were 70 Gy and 76 Gy, respectively, delivered with 2 Gy/fraction. For the chordoma and chondrosarcoma cohorts, the 5-year overall survival and local control rates were 85.6% and 65.3%, and 87.8% and 88.1%, respectively. In total, 10 patients progressed locally: 8 were chordoma patients and 2 chondrosarcoma patients. Both chondrosarcoma failures were in higher-grade tumors (grades 2 and 3). None of the 8 patients with grade 1 chondrosarcoma failed, with a median follow-up of 77 months (range, 34-125). There were 8 radiation-induced late effects-the most significant was a radiation-induced secondary malignancy occurring 6.7 years following IG-IMRT. Gross total resection and age were predictors of local control in the chordoma and chondrosarcoma patients, respectively. We report favorable survival, local control and adverse event rates following high dose IG-IMRT. Further follow-up is needed to confirm long-term efficacy. © The Author(s) 2014. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  1. Preliminary analysis of the induced structural radioactivity inventory of the base-case aqueous accelerator transmutation of waste reactor concept

    International Nuclear Information System (INIS)

    Bezdecny, J.A.; Vance, K.M.; Henderson, D.L.

    1995-01-01

    The purpose of the Los Alamos National Laboratory Accelerator Transmutation of (Nuclear) Waste (ATW) project is the substantial reduction in volume of long-lived high-level radioactive waste of the US in a safe and energy-efficient manner. An evaluation of the ATW concept has four aspects: material balance, energy balance, performance, and cost. An evaluation of the material balance compares the amount of long-lived high-level waste transmuted with the amount and type, of waste created in the process. One component of the material balance is the activation of structural materials over the lifetime of the transmutation reactor. A preliminary radioactivity and radioactive mass balance analysis has been performed on four structure regions of the reaction chamber: the tungsten target, the lead annulus, six tubing materials carrying the actinide slurry, and five reaction vessel structural materials. The amount of radioactive material remaining after a 100-yr cooling period for the base-case ATW was found to be 338 kg of radionuclides. The bulk of this material (313 kg) was generated in the zirconium-niobium (Zr-Nb) actinide tubing material. Replacement of the Zr-Nb tubing material with one of the alternative tubing materials analyzed would significantly reduce the short- and long-term radioactive mass produced. The alternative vessel material Al-6061 alloys, Tenelon, HT-9, and 2 1/4 Cr-1 Mo and the alternative actinide tubing materials Al-6061 alloy, carbon-carbon matrix, silicon carbide, and Ti-6 Al-4 V qualify for shallow land burial. Alternative disposal options for the base-case structural material Type 304L stainless steel and the actinide tubing material Zr-Nb will need to be considered as neither qualifies for shallow land burial

  2. [Simulation-based intervention to improve anesthesiology residents communication with families of critically ill patients--preliminary prospective evaluation].

    Science.gov (United States)

    Berkenstadt, Haim; Perlson, Daria; Shalomson, Orit; Tuval, Atalia; Haviv-Yadid, Yael; Ziv, Amitai

    2013-08-01

    Although effective communication with families of critically ill patients is a vital component of quality care, training in this field is neglected. The article aims to validate communication skills training program for anesthesiology residents in the intensive care set up. Ten anesthesia residents, following 3 months of Intensive Care Unit (ICU) rotation, had 4 hours of lectures and one day simulation-based communication skills training with families of critically ill patients. Participants completed an attitude questionnaire over 3 time periods--before training [t1], immediately following training (t2) and three months following training (t3). The participants' communication skills were assessed by two blinded independent observers using the SEGUE framework while performing a simulation-based scenario at t1 and t3. Seven participants finished the study protocol. Participants ndicated communication importance as 3.68 +/- 0.58 (t1), 4.05 +/- 0.59 (t2), 4.13 +/- 0.64 (t3); their communication ability as 3.09 +/- 0.90 (t1), 3.70 +/- 0.80 (t2), 3.57 +/- 0.64 (t3); the contribution of lecture to communication 3.04 +/- 0.43 (t1), 3.83 +/- 0.39 (t2), 3.87 +/- 0.51 (t3), and contribution of simulation training to communication 3.00 +/- 0.71 (t1), 4.04 +/- 0.52 (t2), 3.84 +/- 0.31 (t3). The differences did not reach statistical significance. Objective assessment of the communication skills using the SEGUE framework indicated that 6/7 participants improved their communication skills, with communication ability before training at 2.66 +/- 0.83 and 1 month following training it was 3.38 +/- 0.78 (p = 0.09). This preliminary study demonstrates the value of communication skills training in the intensive care environment.

  3. Implementation of severe accident management measures - Summary and conclusions

    International Nuclear Information System (INIS)

    2002-01-01

    implemented in various ways in many plants, but not yet in all plants. A systematic approach, which is based upon a clearly defined decision-making process, is one of the features implemented in many cases. Available means are determined and priorities are set. This approach is made up of strategies intended to become an optimum approach to prevent or mitigate the consequences of beyond-design basis accidents. It is based upon a prepared information package about plant-specific behaviour to be expected in beyond design scenarios. The approaches followed in the different countries do not fit one single pattern. Harmonization, to the extent it is desirable, does not seem feasible at this stage. As a rule, the responsibility of the plant owner for the safety of his plant remains untouched. Also, safety goals may vary between countries. This report presents the general conclusion and recommendations of the workshop and the summaries of the sessions

  4. Medical irradiation of children. Beware of too fast conclusion

    International Nuclear Information System (INIS)

    Brisse, H.; Sirinelli, D.; Adamsbaum, C.; Chateil, J.F.; Claudon, M.; Geoffray, A.; Petit, P.; Rausin, L.; Panuel, M.

    2004-01-01

    The publication in january 2004 in the British medical journal of the article of P. Hall and coll. 'Effect of low doses of ionizing irradiation in infancy on cognitive function in adulthood: Swedish population based cohort study, has been noticed by the Radiation protection group of the French speaking society of pediatrics imaging. The authors evaluate the psycho-motor development of less eighteen months years old children and irradiated between 1930 and 1959 for a face angioma. They study for each dose of irradiation ( from 0 to 250 m Gy) the level of school attendance and their results to the psycho-motor tests made during conscription medical examination. They noticed a diminution of 50% of the access success rate to university for the children having received an irradiation dose of 250 mG. No effect is noticed under the irradiation dose of 100 mGy. In their conclusions the authors compare these irradiation doses to these ones delivered in brain scanner examination. These results seem overestimated compared with the work made on fetuses ( publication 84 of ICRP) then the fetus is considered as more sensitive to ionizing radiations than the infant. The dose of 120 mGy is found in the literature and now the dose delivered in pediatrics are in the area of 0 and 100 mGy where no effect has been revealed in the cohort of irradiated children. The article does not include the principle of justification that is used nowadays and the replacement by the trans fontanel echography has allowed to reduce the number of brain scanner, used only for limited cases where the benefit is superior the the risk of irradiation. (N.C.)

  5. Waste Handling Shaft concrete liner degradation conclusions and recommendations

    International Nuclear Information System (INIS)

    1992-10-01

    The primary function of the Waste Handling Shaft (WHS) at the Waste Isolation Pilot Plant (WIPP) is to permit the transfer of radioactive waste from the surface waste handling building to the underground storage area. It also serves as an intake shaft for small volumes of air during normal storage operations and as an emergency escape route. Part of the construction was the placement of a concrete liner and steel reinforced key in 1984. During a routine shaft inspection in May 1990, some degradation of the WHS concrete liner was observed between the depths of 800 and 900 feet below the ground surface. Detailed investigations of the liner had been carried out by Sandia National Laboratories and by Westinghouse Electric Corporation Waste Isolation Division (WID) through Lankard Materials Laboratory. Observations, reports, and data support the conclusion that the concrete degradation, resulting from attack by chemically aggressive brine, is a localized phenomena. It is the opinion of the WID that the degradation is not considered an immediate or near term concern; this is supported by technical experts. WID recommendations have been made which, when implemented, will ensure an extended liner life. Based on the current assessment of available data and the proposed shaft liner monitoring program described in this report, it is reasonable to assume that the operational life of the concrete shaft liner can safely support the 25-year life of the WIPP. Analysis of data indicates that degradation of the shaft's concrete liner is attributed to chemically aggressive brine seeping through construction joints and shrinkage cracks from behind the liner in and around the 834-foot depth. Chemical and mechanical components of concrete degradation have been identified. Chemical attack is comprised of several stages of concrete alteration. The other component, mechanical degradation, results from the expansive forces of crystals forming in the concrete pore space

  6. The Danish energy crop research and development project - main conclusions

    International Nuclear Information System (INIS)

    Gylling, Morten

    2003-01-01

    Production of energy crops in Denmark is more or less non-existent in Denmark at the time being. However, the need for biomass on the other side of year 2005 exceeds the existing biomass resources and a substantial amount of energy crops will be necessary in order to fulfil the goals in Energy 21. The targeted share of the use of renewable energy sources by year 2030 is approximately 30%. Energy crops are seen as the most important new resource in order to create a balanced input mix of renewable in the energy system. The energy crops are mainly seen as fuel in small and medium sized CHP plants and in the big power plants. The Danish energy crop project consists of three main parts: a demonstration part, a research and development part, and an overall assessment part. Based on the results from the project the following overall conclusions can be made: Seen from a strictly market and production economic point of view energy crops will not be competitive in a foreseeable future, neither as a production for farmers nor as a fuel at the utility companies; The costs per GJ of energy crops are still higher than a GJ of straw; The cost difference between annual and perennial energy crops are slightly in favour of perennials, however the conditions on the individual farms should govern the choice between annual and perennial energy crops; Energy crops must be seen as part of an overall environmental scheme covering both agriculture and the energy sector; Given the right production scheme energy crops can be grown on environmental sensitive areas and on most ground water protection areas; Adding the potential sustainability benefits like reduced nutrient leakage and reduced CO 2 emissions energy crops seem to be a sensible and sustainable solution; Due to different handling, storage and fuel characteristics an all year delivery scheme of energy crops should include a mix of different energy crops to keep overall cost down. (BA)

  7. Preliminary evaluation of a telephone-based smoking cessation intervention in the lung cancer screening setting: A randomized clinical trial.

    Science.gov (United States)

    Taylor, Kathryn L; Hagerman, Charlotte J; Luta, George; Bellini, Paula G; Stanton, Cassandra; Abrams, David B; Kramer, Jenna A; Anderson, Eric; Regis, Shawn; McKee, Andrea; McKee, Brady; Niaura, Ray; Harper, Harry; Ramsaier, Michael

    2017-06-01

    Incorporating effective smoking cessation interventions into lung cancer screening (LCS) programs will be essential to realizing the full benefit of screening. We conducted a pilot randomized trial to determine the feasibility and efficacy of a telephone-counseling (TC) smoking cessation intervention vs. usual care (UC) in the LCS setting. In collaboration with 3 geographically diverse LCS programs, we enrolled current smokers (61.5% participation rate) who were: registered to undergo LCS, 50-77 years old, and had a 20+ pack-year smoking history. Eligibility was not based on readiness to quit. Participants completed pre-LCS (T0) and post-LCS (T1) telephone assessments, were randomized to TC (N=46) vs. UC (N=46), and completed a final 3-month telephone assessment (T2). Both study arms received a list of evidence-based cessation resources. TC participants also received up to 6 brief counseling calls with a trained cessation counselor. Counseling calls incorporated motivational interviewing and utilized the screening result as a motivator for quitting. The outcome was biochemically verified 7-day point prevalence cessation at 3-months post-randomization. Participants (56.5% female) were 60.2 (SD=5.4) years old and reported 47.1 (SD=22.2) pack years; 30% were ready to stop smoking in the next 30 days. TC participants completed an average of 4.4 (SD=2.3) sessions. Using intent-to-treat analyses, biochemically verified quit rates were 17.4% (TC) vs. 4.3% (UC), p<.05. This study provides preliminary evidence that telephone-based cessation counseling is feasible and efficacious in the LCS setting. As millions of current smokers are now eligible for lung cancer screening, this setting represents an important opportunity to exert a large public health impact on cessation among smokers who are at very high risk for multiple tobacco-related diseases. If this evidence-based, brief, and scalable intervention is replicated, TC could help to improve the overall cost

  8. Neutronics and activation of the preliminary reaction chamber of HiPER reactor based in a SCLL blanket

    Energy Technology Data Exchange (ETDEWEB)

    Juárez, Rafael, E-mail: rafael.juarez@upm.es [Instituto de Fusión Nuclear, UPM, Madrid (Spain); Escuela Técnica Superior de Ingenieros Industriales, UNED, Madrid (Spain); Sanz, Javier; Lopez-Revelles, A.J. [Escuela Técnica Superior de Ingenieros Industriales, UNED, Madrid (Spain); Perlado, José Manuel [Instituto de Fusión Nuclear, UPM, Madrid (Spain)

    2013-10-15

    Highlights: • Neutronic study of a proposal of a reaction chamber for HiPER reactor. • Two options for the blanket size, thin and thick, are studied and compared. • The thin blanket performs better than the thick blanket. • The proposed Vacuum Vessel is unviable as lifetime component in both cases. • Likely solutions for the Vacuum Vessel lifetime extension are explored. -- Abstract: The HiPER reactor design is exploring different reaction chambers. In this study, we tackle the neutronics and activation studies of a preliminary reaction chamber based in the following technologies: unprotected dry wall for the First Wall, self-cooled lead lithium blanket, and independent low activation steel Vacuum Vessel. The most critical free parameter in this stage is the blanket thickness, as a function of the {sup 6}Li enrichment. After a parametric study, we select for study both a “thin” and “thick” blanket, with “high” and “low” {sup 6}Li enrichment respectively, to reach a TBR = 1.1. To help to make a choice, we compute, for both blanket options, in addition to the TBR, the energy amplification factor, the tritium partial pressure, the {sup 203}Hg and {sup 210}Po total activity in the LiPb loop, and the Vacuum Vessel thickness required to guarantee the reweldability during its lifetime. The thin blanket shows a superior performance in the safety related issues and structural viability, but it operates at higher {sup 6}Li enrichment. It is selected for further improvements. The Vacuum Vessel shows to be unviable in both cases, with the thickness varying between 39 and 52 cm. Further chamber modifications, such as the introduction of a neutron reflector, are required to exploit the benefits of the thin blanket with a reasonable Vacuum Vessel.

  9. Efficacy of a short-term yoga-based lifestyle intervention in reducing stress and inflammation: preliminary results.

    Science.gov (United States)

    Yadav, Raj Kumar; Magan, Dipti; Mehta, Nalin; Sharma, Ratna; Mahapatra, Sushil Chandra

    2012-07-01

    Previously it was shown that a brief yoga-based lifestyle intervention was efficacious in reducing oxidative stress and risk of chronic diseases even in a short duration. The objective of this study was to assess the efficacy of this intervention in reducing stress and inflammation in patients with chronic inflammatory diseases. This study reports preliminary results from a nonrandomized prospective ongoing study with pre-post design. The study was conducted at the Integral Health Clinic, an outpatient facility conducting these yoga-based lifestyle intervention programs for prevention and management of chronic diseases. Patients with chronic inflammatory diseases and overweight/obese subjects were included while physically challenged, and those on other interventions were excluded from the study. A pretested intervention program included asanas (postures), pranayama (breathing exercises), stress management, group discussions, lectures, and individualized advice. There was a reduction in stress (plasma cortisol and β-endorphin) and inflammation (interleukin [IL]-6 and tumor necrosis factor [TNF]-α) at day 0 versus day 10. Eighty-six (86) patients (44 female, 42 male, 40.07 ± 13.91 years) attended this program. Overall, the mean level of cortisol decreased from baseline to day 10 (149.95 ± 46.07, 129.07 ± 33.30 ng/mL; p=0.001) while β-endorphins increased from baseline to day 10 (3.53 ± 0.88, 4.06 ± 0.79 ng/mL; p=0.024). Also, there was reduction from baseline to day 10 in mean levels of IL-6 (2.16 ± 0.42, 1.94 ± 0.10 pg/mL, p=0.036) and TNF-α (2.85 ± 0.59, 1.95 ± 0.32 pg/mL, p=0.002). This brief yoga-based lifestyle intervention reduced the markers of stress and inflammation as early as 10 days in patients with chronic diseases; however, complete results of this study will confirm whether this program has utility as complementary and alternative therapy.

  10. Medical irradiation of children. Beware of too fast conclusion; Irradiation medicale de l'enfant. Attention aux conclusions hatives

    Energy Technology Data Exchange (ETDEWEB)

    Brisse, H. [Institut Curie, Dept. d' Imagerie, 75 - Paris (France); Sirinelli, D. [Hopital Clocheville, Service de Radiologie et Echographie, 37 - Tours (France); Adamsbaum, C. [Hopital Saint-Vincent-de-Paul, Service de Radiologie, 75 - Paris (France); Chateil, J.F. [Hopital Pellegrin, Unite de Radiopediatrie, 33 - Bordeaux (France); Claudon, M. [Centre Hospitalier Universitaire Nancy-Hopital Brabois Enfants, Service de Radiologie, 54 - Vandoeuvre-les-Nancy (France); Geoffray, A. [Fondation Lenval, Service de Radiologie, 06 - Nice (France); Petit, P. [Hopital de la Timone, Service de Radiologie, 13 - Marseille (France); Rausin, L. [Centre Hospitalier Regional de la Citadelle, Service de Radiologie, Liege (Belgium); Panuel, M. [Hopital Nord, Service de Radiologie, 13 - Marseille (France)

    2004-10-01

    The publication in january 2004 in the British medical journal of the article of P. Hall and coll. 'Effect of low doses of ionizing irradiation in infancy on cognitive function in adulthood: Swedish population based cohort study, has been noticed by the Radiation protection group of the French speaking society of pediatrics imaging. The authors evaluate the psycho-motor development of less eighteen months years old children and irradiated between 1930 and 1959 for a face angioma. They study for each dose of irradiation ( from 0 to 250 m Gy) the level of school attendance and their results to the psycho-motor tests made during conscription medical examination. They noticed a diminution of 50% of the access success rate to university for the children having received an irradiation dose of 250 mG. No effect is noticed under the irradiation dose of 100 mGy. In their conclusions the authors compare these irradiation doses to these ones delivered in brain scanner examination. These results seem overestimated compared with the work made on fetuses ( publication 84 of ICRP) then the fetus is considered as more sensitive to ionizing radiations than the infant. The dose of 120 mGy is found in the literature and now the dose delivered in pediatrics are in the area of 0 and 100 mGy where no effect has been revealed in the cohort of irradiated children. The article does not include the principle of justification that is used nowadays and the replacement by the trans fontanel echography has allowed to reduce the number of brain scanner, used only for limited cases where the benefit is superior the the risk of irradiation. (N.C.)

  11. Preliminary Overview of a Helium Cooling System for the Secondary Helium Loop in VHTR-based SI Hydrogen Production Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Youngjoon; Cho, Mintaek; Kim, Dahee; Lee, Taehoon; Lee, Kiyoung; Kim, Yongwan [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    Nuclear hydrogen production facilities consist of a very high temperature gas-cooled nuclear reactor (VHTR) system, intermediate heat exchanger (IHX) system, and a sulfur-iodine (SI) thermochemical process. This study focuses on the coupling system between the IHX system and SI thermochemical process. To prevent the propagation of the thermal disturbance owing to the abnormal operation of the SI process components from the IHX system to the VHTR system, a helium cooling system for the secondary helium of the IHX is required. In this paper, the helium cooling system has been studied. The temperature fluctuation of the secondary helium owing to the abnormal operation of the SI process was then calculated based on the proposed coupling system model. Finally, the preliminary conceptual design of the helium cooling system with a steam generator and forced-draft air-cooled heat exchanger to mitigate the thermal disturbance has been carried out. A conceptual flow diagram of a helium cooling system between the IHX and SI thermochemical processes in VHTR-based SI hydrogen production facilities has been proposed. A helium cooling system for the secondary helium of the IHX in this flow diagram prevents the propagation of the thermal disturbance from the IHX system to the VHTR system, owing to the abnormal operation of the SI process components. As a result of a dynamic simulation to anticipate the fluctuations of the secondary helium temperature owing to the abnormal operation of the SI process components with a hydrogen production rate of 60 mol·H{sub 2}/s, it is recommended that the maximum helium cooling capacity to recover the normal operation temperature of 450 .deg. C is 31,933.4 kJ/s. To satisfy this helium cooling capacity, a U-type steam generator, which has a heat transfer area of 12 m{sup 2}, and a forced-draft air-cooled condenser, which has a heat transfer area of 12,388.67 m{sup 2}, are required for the secondary helium cooling system.

  12. Debris impact on emergency coolant recirculation - summary and conclusions

    International Nuclear Information System (INIS)

    Jain, Bhagwat; Hsia, Anthony; Armand, Yves; Mattei, Jean-Marie; Hyvaerinen, Juhani; Maqua, Michael; Puetter, Bernhard; Sandervaag, Oddbjoern; Vandewalle, Andre; Tombuyses, Beatrice; Pyy, Pekka; Royen, Jacques

    2004-01-01

    to two orders of magnitude because of strainer clogging. Consequently, the CSNI decided to continue its previous efforts in the area. The overall purpose of the 2004 Workshop was to discuss the impact of new information made available since 1996 and to promote consensus among member countries on identification of remaining technical issues important to safety, and on possible paths for their resolution. The specific purposes of the Workshop were: a. To review the knowledge base and in particular information developed after 1999, and to consider the validity of the conclusions drawn. b. To exchange information on the current status of research related to debris generation, debris transportation, and sump strainer clogging and penetration phenomena, in particular for PWRs, and to assess uncertainties. c. To exchange and disseminate information on recent and current activities and practices in these areas. d. To identify and discuss differences between approaches relevant to reactor safety. e. To identify technical issues and programs of interest for international collaborative research and develop an Action Plan outlining activities that CSNI should undertake in the area of strainer or sump screen clogging during the next few years. Summary of the main findings: a. The safety significance of the sump strainer clogging depends on the plant design (e.g. sump strainer, ECCS) and backfitting measures performed. b. The following are examples of PWR design features that could influence the debris impact on the ECCS sump performance: - Type of insulation (material, combination of materials, protection). - Break size to be postulated. - Transport in containment with or without containment spray system (CSS). - Degree of turbulence and flow velocities in the sump influenced by CSS, water level, break flow location and sump geometry. - Redundancy of sumps and residual heat removal system (RHRS). - Strainer design (area, mesh size). - Positioning of recirculation pumps and vortex

  13. Research on the Reform of the Preliminary Course of Architectural Design Based on Innovation & Practice Ability Training

    Science.gov (United States)

    Yuping, Cai; Shuang, Liang

    2017-01-01

    The traditional undergraduate education mode of architecture has been unable to adapt to the rapid development of society. Taking the junior professional course of architecture--the preliminary course of architectural design as an example, this paper analyzes the problems existing in the current professional courses of lower grades, puts forward…

  14. MRI-based brain structure volumes in temporal lobe epilepsy patients and their unaffected siblings: a preliminary study.

    LENUS (Irish Health Repository)

    Scanlon, Cathy

    2013-01-01

    Investigating the heritability of brain structure may be useful in simplifying complicated genetic studies in temporal lobe epilepsy (TLE). A preliminary study is presented to determine if volume deficits of candidate brain structures present at a higher rate in unaffected siblings than controls subjects.

  15. A fallacious jar? The peculiar relation between descriptive premises and normative conclusions in neuroethics.

    Science.gov (United States)

    Wagner, Nils-Frederic; Northoff, Georg

    2015-06-01

    Ethical questions have traditionally been approached through conceptual analysis. Inspired by the rapid advance of modern brain imaging techniques, however, some ethical questions appear in a new light. For example, hotly debated trolley dilemmas have recently been studied by psychologists and neuroscientists alike, arguing that their findings can support or debunk moral intuitions that underlie those dilemmas. Resulting from the wedding of philosophy and neuroscience, neuroethics has emerged as a novel interdisciplinary field that aims at drawing conclusive relationships between neuroscientific observations and normative ethics. A major goal of neuroethics is to derive normative ethical conclusions from the investigation of neural and psychological mechanisms underlying ethical theories, as well as moral judgments and intuitions. The focus of this article is to shed light on the structure and functioning of neuroethical arguments of this sort, and to reveal particular methodological challenges that lie concealed therein. We discuss the methodological problem of how one can--or, as the case may be, cannot--validly infer normative conclusions from neuroscientific observations. Moreover, we raise the issue of how preexisting normative ethical convictions threaten to invalidate the interpretation of neuroscientific data, and thus arrive at question-begging conclusions. Nonetheless, this is not to deny that current neuroethics rightly presumes that moral considerations about actual human lives demand empirically substantiated answers. Therefore, in conclusion, we offer some preliminary reflections on how the discussed methodological challenges can be met.

  16. Hypothesis, Prediction, and Conclusion: Using Nature of Science Terminology Correctly

    Science.gov (United States)

    Eastwell, Peter

    2012-01-01

    This paper defines the terms "hypothesis," "prediction," and "conclusion" and shows how to use the terms correctly in scientific investigations in both the school and science education research contexts. The scientific method, or hypothetico-deductive (HD) approach, is described and it is argued that an understanding of the scientific method,…

  17. Conclusion Chapters in Doctoral Theses: Some International Findings

    Science.gov (United States)

    Trafford, Vernon; Leshem, Shosh; Bitzer, Eli

    2014-01-01

    This study investigated how candidates claimed to have made an original contribution to knowledge in the conclusion chapters of 100 PhD theses. Documentary analysis was used to discover how this was explained within theses at selected universities in three countries. No other documents were accessed and neither were candidates, supervisors or…

  18. 20 CFR 901.48 - Proposed findings and conclusions.

    Science.gov (United States)

    2010-04-01

    ... Law Judge, before making his/her decision, shall give the parties a reasonable opportunity to submit... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Proposed findings and conclusions. 901.48 Section 901.48 Employees' Benefits JOINT BOARD FOR THE ENROLLMENT OF ACTUARIES REGULATIONS GOVERNING THE...

  19. Actual Problems of Conclusion and Discharge of Urgent Labour Contracts

    Directory of Open Access Journals (Sweden)

    Shevelyova A. A.

    2013-05-01

    Full Text Available This article is devoted to the consideration of the questions connected with the conclusion and the termination of the urgent labour contract. The author, analyzing judicial practice, allocates the problems of separate regulation of the RF labour legislation enforcement.

  20. StopWatch: The preliminary evaluation of a smartwatch-based system for passive detection of cigarette smoking.

    Science.gov (United States)

    Skinner, Andrew L; Stone, Christopher J; Doughty, Hazel; Munafò, Marcus R

    2018-01-24

    Recent developments in smoking cessation support systems and interventions have highlighted the requirement for unobtrusive, passive ways to measure smoking behaviour. A number of systems have been developed for this that either use bespoke sensing technology, or expensive combinations of wearables and smartphones. Here we present StopWatch, a system for passive detection of cigarette smoking that runs on a low-cost smartwatch and does not require additional sensing or a connected smartphone. Our system uses motion data from the accelerometer and gyroscope in an Android smartwatch to detect the signature hand movements of cigarette smoking. It uses machine learning techniques to transform raw motion data into motion features, and in turn into individual drags and instances of smoking. These processes run on the smartwatch, and do not require a smartphone. We conducted preliminary validations of the system in daily smokers (n=13) in laboratory and free-living conditions running on an Android LG G-Watch. In free-living conditions, over a 24-hour period, the system achieved precision of 86% and recall of 71%. StopWatch is a system for passive measurement of cigarette smoking that runs entirely on a commercially available Android smartwatch. It requires no smartphone so the cost is low, and needs no bespoke sensing equipment so participant burden is also low. Performance is currently lower than other more expensive and complex systems, though adequate for some applications. Future developments will focus on enhancing performance, validation on a range of smartwatches, and detection of electronic cigarette use. We present a low-cost, smartwatch-based system for passive detection of cigarette smoking. It uses data from the motion sensors in the watch to identify the signature hand movements of cigarette smoking. The system will provide the detailed measures of individual smoking behaviour needed for context-triggered just-in-time smoking cessation support systems, and to

  1. Cosmological Gamma-Ray Bursts and Hypernovae Conclusively Linked

    Science.gov (United States)

    2003-06-01

    Clearest-Ever Evidence from VLT Spectra of Powerful Event Summary A very bright burst of gamma-rays was observed on March 29, 2003 by NASA's High Energy Transient Explorer (HETE-II) , in a sky region within the constellation Leo. Within 90 min, a new, very bright light source (the "optical afterglow") was detected in the same direction by means of a 40-inch telescope at the Siding Spring Observatory (Australia) and also in Japan. The gamma-ray burst was designated GRB 030329 , according to the date. And within 24 hours, a first, very detailed spectrum of this new object was obtained by the UVES high-dispersion spectrograph on the 8.2-m VLT KUEYEN telescope at the ESO Paranal Observatory (Chile). It allowed to determine the distance as about 2,650 million light-years (redshift 0.1685). Continued observations with the FORS1 and FORS2 multi-mode instruments on the VLT during the following month allowed an international team of astronomers [1] to document in unprecedented detail the changes in the spectrum of the optical afterglow of this gamma-ray burst . Their detailed report appears in the June 19 issue of the research journal "Nature". The spectra show the gradual and clear emergence of a supernova spectrum of the most energetic class known, a "hypernova" . This is caused by the explosion of a very heavy star - presumably over 25 times heavier than the Sun. The measured expansion velocity (in excess of 30,000 km/sec) and the total energy released were exceptionally high, even within the elect hypernova class. From a comparison with more nearby hypernovae, the astronomers are able to fix with good accuracy the moment of the stellar explosion. It turns out to be within an interval of plus/minus two days of the gamma-ray burst. This unique conclusion provides compelling evidence that the two events are directly connected. These observations therefore indicate a common physical process behind the hypernova explosion and the associated emission of strong gamma

  2. Conclusion: imaging in strategy of endocrine diagnosis and therapeutics

    International Nuclear Information System (INIS)

    Mornex, R.

    1995-01-01

    Images in medicine have to help the doctor in a diagnostic or therapeutic aim. The choice must be made in function of pathology or organ as known (it is not necessary to ask for a computed tomography where we know that only an echography can give the answer to the question we ask ), the criteria must stay the best performance for the cheapest price, but the quality of interpretation is a more important thing. It is important to avoid a lot of examinations which do not give better informations but are heavy to endure for the patients. In conclusion, the aim of this kind of proceedings is to assure to the patients who come confidently to us, the best service at the less constraints price without forgetting that a conclusion depends on a given methodological situation and reminding of beside machines we have not to forget the men

  3. Conclusive identification of quantum channels via monogamy of quantum correlations

    International Nuclear Information System (INIS)

    Kumar, Asutosh; Singha Roy, Sudipto; Pal, Amit Kumar; Prabhu, R.; Sen, Aditi; Sen, Ujjwal

    2016-01-01

    We investigate the action of global noise and local channels, namely, amplitude-damping, phase-damping, and depolarizing channels, on monogamy of quantum correlations, such as negativity and quantum discord, in three-qubit systems. We discuss the monotonic and non-monotonic variation, and robustness of the monogamy scores. By using monogamy scores, we propose a two-step protocol to conclusively identify the noise applied to the quantum system, by using generalized Greenberger–Horne–Zeilinger and generalized W states as resource states. We discuss a possible generalization of the results to higher number of parties. - Highlights: • Monogamy score monotonically decays with noise for generalized GHZ state as input. • Non-monotonically decaying monogamy score with noise for generalized W state as input. • Characterizing the dynamics of monogamy score. • Dynamics terminal quantifying robustness of monogamy score against noise. • Conclusively identifying the type of noise using monogamy score.

  4. Conclusive identification of quantum channels via monogamy of quantum correlations

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Asutosh; Singha Roy, Sudipto; Pal, Amit Kumar [Harish-Chandra Research Institute, Chhatnag Road, Jhunsi, Allahabad 211019 (India); Homi Bhaba National Institute, Training School Complex, Anushaktinagar, Mumbai 400094 (India); Prabhu, R. [Harish-Chandra Research Institute, Chhatnag Road, Jhunsi, Allahabad 211019 (India); Homi Bhaba National Institute, Training School Complex, Anushaktinagar, Mumbai 400094 (India); Department of Physics, Indian Institute of Technology Patna, Bihta 801103, Bihar (India); Sen, Aditi, E-mail: aditi@hri.res.in [Harish-Chandra Research Institute, Chhatnag Road, Jhunsi, Allahabad 211019 (India); Homi Bhaba National Institute, Training School Complex, Anushaktinagar, Mumbai 400094 (India); Sen, Ujjwal [Harish-Chandra Research Institute, Chhatnag Road, Jhunsi, Allahabad 211019 (India); Homi Bhaba National Institute, Training School Complex, Anushaktinagar, Mumbai 400094 (India)

    2016-10-23

    We investigate the action of global noise and local channels, namely, amplitude-damping, phase-damping, and depolarizing channels, on monogamy of quantum correlations, such as negativity and quantum discord, in three-qubit systems. We discuss the monotonic and non-monotonic variation, and robustness of the monogamy scores. By using monogamy scores, we propose a two-step protocol to conclusively identify the noise applied to the quantum system, by using generalized Greenberger–Horne–Zeilinger and generalized W states as resource states. We discuss a possible generalization of the results to higher number of parties. - Highlights: • Monogamy score monotonically decays with noise for generalized GHZ state as input. • Non-monotonically decaying monogamy score with noise for generalized W state as input. • Characterizing the dynamics of monogamy score. • Dynamics terminal quantifying robustness of monogamy score against noise. • Conclusively identifying the type of noise using monogamy score.

  5. Biogeochemistry of uranium mill wastes program overview and conclusions

    International Nuclear Information System (INIS)

    Dreesen, D.R.

    1981-05-01

    The major findings and conclusions are summarized for research on uranium mill tailings for the US Department of Energy and the US Nuclear Regulatory Commission. An overview of results and interpretations is presented for investigations of 222 Rn emissions, revegetation of tailings and mine spoils, and trace element enrichment, mobility, and bioavailability. A brief discussion addresses the implications of these findings in relation to tailings disposal technology and proposed uranium recovery processes

  6. Summary and Conclusions. Final chapter of Scholarly Communication for Librarians.

    OpenAIRE

    Morrison, Heather

    2008-01-01

    Summary and Conclusions of Scholarly Communication for Librarians, a book designed to provide librarians at all levels with the basics of how scholarly communication works, an understanding of the academic library as an essential support for scholarly communication, the impact of the decisions librarians make, and emerging roles for libraries and librarians in scholarly communication. Includes major points from all chapters, on: scholarship, scholarly journals, the scholarly publishing indus...

  7. Relationship Dissolution and Psychologically Aggressive Dating Relationships: Preliminary Findings From a College-Based Relationship Education Course.

    Science.gov (United States)

    Negash, Sesen; Cravens, Jaclyn D; Brown, Preston C; Fincham, Frank D

    This study evaluated the impact of a relationship education program, delivered as part of a college course, among students (N = 152) who reported experiencing psychological aggression in their exclusive dating relationship. Preliminary results showed that compared to those in the control group, participants receiving relationship education were significantly more likely to end their romantic relationship, even after controlling for relationship satisfaction. Furthermore, when relationship termination occurred, those in the intervention group were significantly more likely to attribute the breakup to their participation in the class as compared to those in the control group. The tentative findings are an important preliminary step in assessing the benefits of relationship education in reducing the risk of psychological aggression among college students.

  8. The Alaska earthquake, March 27, 1964: lessons and conclusions

    Science.gov (United States)

    Eckel, Edwin B.

    1970-01-01

    local waves. Better earthquake-hazard maps, based on improved knowledge of regional geology, fault behavior, and earthquake mechanisms, are needed for the entire country. Their preparation will require the close collaboration of engineers, seismologists, and geologists. Geologic maps of all inhabited places in earthquake-prone parts of the country are also needed by city planners and others, because the direct relationship between local geology and potential earthquake damage is now well understood. Improved and enlarged nets of earthquake-sensing instruments, sited in relation to known geology, are needed, as are many more geodetic and hydrographic measurements. Every large earthquake, wherever located, should be regarded as a full-scale laboratory experiment whose study can give scientific and engineering information unobtainable from any other source. Plans must be made before the event to insure staffing, funding, and coordination of effort for the scientific and engineering study of future earthquakes. Advice of earth scientists and engineers should be used in the decision-making processes involved in reconstruction after any future disastrous earthquake, as was done after the Alaska earthquake. The volume closes with a selected bibliography and a comprehensive index to the entire series of U.S. Geological Survey Professional Papers 541-546. This is the last in a series of six reports that the U.S. Geological Survey published on the results of a comprehensive geologic study that began, as a reconnaissance survey, within 24 hours after the March 27, 1964, Magnitude 9.2 Great Alaska Earthquake and extended, as detailed investigations, through several field seasons. The 1964 Great Alaska earthquake was the largest earthquake in the U.S. since 1700. Professional Paper 546, in 1 part, describes Lessons and Conclusions.

  9. A Preliminary Investigation of NSCL/P Plasma and Urine in Guizhou Province in China Using NMR-Based Metabonomics.

    Science.gov (United States)

    Lei, Huang Guang; Hong, Luo; Kun, Song Ju; Hai, Yin Xin; Dong, Wang Ya; Ke, Zhao; Ping, Xu; Hao, Chen

    2013-09-01

    Objective : To assess the feasibility of metabonomics in clinical studies. This is a pilot study introducing nuclear magnetic resonance (NMR)-based metabonomics to elucidate and compare the metabolism of patients with nonsyndromic cleft lip and/or palate (NSCL/P) and children without orofacial clefts. Methods : High-resolution (1)H NMR spectroscopy was performed on plasma and urine samples obtained from NSCL/P and healthy children. The (1)H NMR spectra were further analyzed with principal component analysis. Results : Compared to the control group, the level of low-molecular-weight metabolites in plasma such as asparagine was higher in NSCL/P patients, while arginine, lysine, acetate, lactate, proline, glutamine, pyruvate, creatinine, choline, and β-glucose were lower. The carnitine, citrate, and formate excretion in urine appeared to be higher in the healthy children, while the NSCL/P group excreted higher concentrations of aspartic acid and phenylalanine in urine. Conclusion : The present study clearly demonstrated the great potential of NMR-based metabonomics in elucidating NSCL/P plasma metabolism and the possible application of this technology in clinical diagnosis and screening.

  10. It pays to be green. A premature conclusion?

    International Nuclear Information System (INIS)

    Telle, K.

    2006-01-01

    It has been claimed that good environmental performance can improve firms' economic performance. However, because of e.g. data limitations, the methods applied in most previous quantitative empirical studies on effects of environmental performance on economic performance of firms suffer from several shortcomings. We discuss these shortcomings and conclude that previously applied methods are unsatisfactory as support for a conclusion that it pays for firms to be green. Then we illustrate the consequences of these shortcomings by performing several regression analyses of the effect of environmental performance on economic performance using a panel data set of Norwegian plants. A pooled regression where observable firm characteristics like e.g. size or industry are controlled for, confirms a positive effect of environmental performance on economic performance. However, the estimated positive effect could be due to omitted unobserved variables like management or technology. When the regression model controls for unobserved plant heterogeneity, the effect is generally no longer statistically significant. Hence, although greener plants tend to perform economically better, the analysis provides little support for the claim that it is because they are greener. These empirical findings further indicate that a conclusion that it pays to be green is premature

  11. Conclusion of the I.C.T. benchmark exercise

    International Nuclear Information System (INIS)

    Giacometti, A.

    1991-01-01

    The ICT Benchmark exercise made within the RIV working group of ESARDA on reprocessing data supplied by COGEMA for 53 routines reprocessing input batches made of 110 irradiated fuel assemblies from KWO Nuclear Power Plant was finally evaluated. The conclusions are: all seven different ICT methods applied verified the operator data on plutonium within about one percent; anomalies intentionally introduced to the operator data were detected in 90% of the cases; the nature of the introduced anomalies, which were unknown to the participants, was completely resolved for the safeguards relevant cases; the false alarm rate was in a few percent range. The ICT Benchmark results shows that this technique is capable of detecting and resolving anomalies in the reprocessing input data to the order of a percent

  12. The no conclusion intervention for couples in conflict.

    Science.gov (United States)

    Migerode, Lieven

    2014-07-01

    Dealing with difference is central to all couple therapy. This article presents an intervention designed to assist couples in handling conflict. Central to this approach is the acceptance that most conflicts cannot be solved. Couples are in need of a different understanding of couples conflict. This understanding is found in the analysis of love in context and in relational dialectics. Couples are guided through different steps: deciding on the valence of the issue as individuals, helping them decide which differences can be resolved and which issues demand new ways of living with the inevitable, and the introduction in the suggested no conclusion dialogue. This article briefly describes the five day intensive couple therapy program, in which the no intervention is embedded. The theoretical foundation of the intervention, followed by the step by step description of the intervention forms the major part of the article. A case vignette illustrates this approach. © 2012 American Association for Marriage and Family Therapy.

  13. The European Food Consumption Validation Project: conclusions and recommendations

    DEFF Research Database (Denmark)

    de Boer, E. J.; Slimani, N.; van 't Veer, P.

    2011-01-01

    Background/Objectives: To outline and discuss the main results and conclusions of the European Food Consumption Validation (EFCOVAL) Project. Subjects/Methods: The EFCOVAL Project was carried out within the EU Sixth Framework Program by researchers in 11 EU countries. The activities focused on (1...... showed that two non-consecutive EPIC-Soft 24-HDRs are suitable to estimate the usual intake distributions of protein and potassium of European adult populations. The 2-day non-consecutive 24-HDRs in combination with a food propensity questionnaire also appeared to be appropriate to rank individuals...... according to their fish and fruit and vegetable intake in a comparable way in five European centers. Dietary intake of (young) children can be assessed by the combination of EPIC-Soft 24-HDRs and food recording booklets. The EPIC-Soft-standardized method of describing foods is useful to estimate dietary...

  14. The accident at the Harrisburg nuclear reactor - Interim conclusions

    International Nuclear Information System (INIS)

    Yiftah, S.

    1979-07-01

    This work describes the first minutes, first day and first week following the Three Mile Island accident. It shows the failures that occurred and the lessons which should be derived. It is pointed out that the doses of radiation that escaped from the TMI plant were at no time large enough to have had any effect on the 2 million people living on a radius of 80 km from the plant. Although no casualties occurred the Harrisburg accident will create an impulse for a new study and understanding of the nuclear plant safety and might serve as a live safety laboratory. After the TMI accident nuclear plants are already safer, one of the conclusions being that a new planning of the operation room is required, with the operators acquiring a better understanding of what is going on during a nuclear reactor accident. (B.G.)

  15. Workshop on large molten pool heat transfer summary and conclusions

    International Nuclear Information System (INIS)

    1994-01-01

    The CSNI Workshop on Large Molten Heat Transfer held at Grenoble (France) in March 1994 was organised by CSNI's Principal Working Group on the Confinement of Accidental Radioactive Releases (PWG4) with the cooperation of the Principal Working Group on Coolant System Behaviour (FWG2) and in collaboration with the Grenoble Nuclear Research Centre of the French Commissariat a l'Energie Atomique (CEA). Conclusions and recommendations are given for each of the five sessions of the workshops: Feasibility of in-vessel core debris cooling through external cooling of the vessel; Experiments on molten pool heat transfer; Calculational efforts on molten pool convection; Heat transfer to the surrounding water - experimental techniques; Future experiments and ex-vessel studies (open forum discussion)

  16. Jumping to conclusions and the continuum of delusional beliefs.

    Science.gov (United States)

    Warman, Debbie M; Lysaker, Paul H; Martin, Joel M; Davis, Louanne; Haudenschield, Samantha L

    2007-06-01

    The present study examined the jumping to conclusions reasoning bias across the continuum of delusional ideation by investigating individuals with active delusions, delusion prone individuals, and non-delusion prone individuals. Neutral and highly self-referent probabilistic reasoning tasks were employed. Results indicated that individuals with delusions gathered significantly less information than delusion prone and non-delusion prone participants on both the neutral and self-referent tasks, (preferent task (p=.002). Those with delusions and those who were delusion prone reported higher confidence in their performance on the self-referent task than they did the neutral task (p=.02), indicating that high self-reference impacted information processing for individuals in both of these groups. The results are discussed in relation to previous research in the area of probabilistic reasoning and delusions.

  17. A web-based survey of the relationship between buddhist religious practices, health, and psychological characteristics: research methods and preliminary results.

    Science.gov (United States)

    Wiist, W H; Sullivan, B M; Wayment, H A; Warren, M

    2010-03-01

    A Web-based survey was conducted to study the religious and health practices, medical history and psychological characteristics among Buddhist practitioners. This report describes the development, advertisement, administration and preliminary results of the survey. Over 1200 Buddhist practitioners responded. Electronic advertisements were the most effective means of recruiting participants. Survey participants were mostly well educated with high incomes and white. Participants engaged in Buddhist practices such as meditation, attending meetings and obtaining instruction from a monk or nun, and practiced healthful behaviors such as regular physical activity and not smoking. Buddhist meditative practice was related to psychological mindfulness and general health.

  18. Preliminary design report of a relativistic-Klystron two-beam-accelerator based power source for a 1 TeV center-of-mass next linear collider

    International Nuclear Information System (INIS)

    Yu, S.; Goffeney, N.; Henestroza, E.

    1995-01-01

    A preliminary point design for an 11.4 GHz power source for a 1 TeV center-of-mass Next Linear Collider (NLC) based on the Relativistic-Klystron Two-Beam-Accelerator (RK-TBA) concept is presented. The present report is the result of a joint LBL-LLNL systems study. consisting of three major thrust areas: physics, engineering, and costing. The new RK-TBA point design, together with our findings in each of these areas, are reported

  19. A population-based study of cognitive impairment in socially vulnerable adults in Argentina. The Matanza Riachuelo study preliminary results

    Science.gov (United States)

    Bartoloni, Leonardo; Blatt, Graciela; Insua, Iván; Furman, Mariano; González, María Agustina; Hermann, Bárbara; Kesselman, Mariana; Massautis, Alicia; Reinado, Alejandra; Senas, Patricia; Yavitz, Claudia; Lejarraga, Horacio; Nunes, Fernando; Arizaga, Raúl Luciano; Allegri, Ricardo F

    2014-01-01

    Population aging has taken place intensively worldwide, even in developing countries. These countries have population groups with low resources and basic unmet needs that are frequently omitted from epidemiological studies. Objective The purpose of this study was to determine the prevalence of cognitive impairment (CI) and dementia in an economic and socially vulnerable population from Argentina. Methods A door-to-door observational population-based survey among adults over 60 years of cognitive impairment and dementia in the social vulnerable area of the Matanza Riachuelo Basin, in the suburban area of Buenos Aires, Argentina was conducted. Trained psychologists interviewed subjects and a proxy informant. A standardized protocol including a socio-demographic questionnaire, the Mini-Mental State Examination, the Geriatric Depression Scale and a functional inventory for IADL and ADL was administered. Diagnoses were divided into three general categories: normal cognitive function, cognitive impairment-no dementia (CIND) and dementia. Results and Conclusions A total of 2437 elderly persons were assessed, of which 73.6% fulfilled inclusion criteria. The prevalence of CI among those over 60 was 26.4% (18.1% CIND and 8.3% dementia) with higher prevalence of dementia in younger individuals than rates reported in developed counties, probably due to low control of vascular risk factors. This information can help inform health public decisions in the generation of programs and plans for the prevention, diagnosis and treatment of cognitive impairment in this type of socially vulnerable population. PMID:29213923

  20. Quick scan of Participatory Action, Summary, conclusions and recommendations

    NARCIS (Netherlands)

    Verhagen, H.J.

    2005-01-01

    Projects using innovative concepts in coastal defence -like ComCoast- can benefit greatly from participatory action. It can lead to innovative solutions with a broad societal support base, as is shown in the plan for water storage in the Overdiepse polder and the inundation compensation scheme for

  1. Plurihormonal cells of normal anterior pituitary: Facts and conclusions

    Science.gov (United States)

    Mitrofanova, Lubov B.; Konovalov, Petr V.; Krylova, Julia S.; Polyakova, Victoria O.; Kvetnoy, Igor M.

    2017-01-01

    Introduction plurihormonality of pituitary adenomas is an ability of adenoma cells to produce more than one hormone. After the immunohistochemical analysis had become a routine part of the morphological study, a great number of adenomas appeared to be multihormonal in actual practice. We hypothesize that the same cells of a normal pituitary gland releases several hormones simultaneously. Objective To analyse a possible co-expression of hormones by the cells of the normal anterior pituitary of adult humans in autopsy material. Materials and methods We studied 10 pituitary glands of 4 women and 6 men with cardiovascular and oncological diseases. Double staining immunohistochemistry using 11 hormone combinations was performed in all the cases. These combinations were: prolactin/thyroid-stimulating hormone (TSH), prolactin/luteinizing hormone (LH), prolactin/follicle-stimulating hormone (FSH), prolactin/adrenocorticotropic hormone (ACTH), growth hormone (GH)/TSH, GH/LH, GH/FSH, GH/ACTH, TSH/LH, TSH/FSH, TSH/ACTH. Laser Confocal Scanning Microscopy with a mixture of primary antibodies was performed in 2 cases. These mixtures were ACTH/prolactin, FSH/prolactin, TSH/prolactin, ACTH/GH, and FSH/GH. Results We found that the same cells of the normal adenohypophysis can co-express prolactin with ACTH, TSH, FSH, LH; GH with ACTH, TSH, FSH, LH, and TSH with ACTH, FSH, LH. The comparison of the average co-expression coefficients of prolactin, GH and TSH with other hormones showed that the TSH co-expression coefficient was significantly the least (9,5±6,9%; 9,6±7,8%; 1,0±1,3% correspondingly). Conclusion Plurihormonality of normal adenohypophysis is an actually existing phenomenon. Identification of different hormones in pituitary adenomas enables to find new ways to improve both diagnostic process and targeted treatment. PMID:28418929

  2. Hanford study: a review of its limitations and controversial conclusions

    International Nuclear Information System (INIS)

    Gilbert, E.S.

    1984-10-01

    The Hanford data set has attracted attention primarily because of analyses conducted by Mancuso, Stewart, and Kneale (MSK). These investigators claim that the Hanford data provide evidence that our current estimates of cancer mortality resulting from radiation exposure are too low, and advocate replacing estimates based on populations exposed at relatively high doses (such as the Japanese atom bomb survivors) with estimates based on the Hanford data. In this paper, it is shown that the only evidence of association of radiation exposure and mortality provided by the Hanford data is a small excess of multiple myeloma, and that this data set is not adequate for reliable risk estimation. It is demonstrated that confidence limits for risk estimates are very wide, and that the data are not adequate to differentiate among models. The more recent MSK analyses, which claim to provide adequate models and risk estimates, are critiqued. 18 references, 1 table

  3. Modeling and preliminary characterization of passive, wireless temperature sensors for harsh environment applications based on periodic structures

    Science.gov (United States)

    Delfin Manriquez, Diego I.

    Wireless temperature sensing has attained significant attention in recent years due to the increasing need to develop reliable and affordable sensing solutions for energy conversion systems and other harsh environment applications. The development of next generation sensors for energy production processing parameters, such as temperature and pressure, can result in better performance of the system. Particularly, continuous temperature monitoring in energy conversion systems can result in enhancements such as better system integrity, less pollution and higher thermal efficiencies. However, the conditions experienced in these system components hinder the performance of current solutions due to the presence of semi-conductor materials and welded joints. Additionally, the use of wired systems can result in complex wiring networks, increasing the cost of installation, maintenance and sensor replacement. Therefore, next generation sensing solutions must be developed to overcome current challenges in systems where adverse conditions are present. This research project proposes two novel passive, wireless temperature sensor designs based on concepts of guided mode resonance filters (GMRF) and metamaterials. For the GMRF, a tri-layer structure using a metallic encasing and a circular aperture grating layer was developed to have a resonance frequency of 10 GHz. While for the metamaterial-based sensor a continuation of previous work was presented by utilizing a dielectric substrate and an array of commercially available metallic washers divided in two layers. For both designs, High Frequency Structure Simulator (HFSS) from ANSYSRTM was employed to assess the feasibility of the sensor as well as to optimize the geometry and guide the fabrication process. A systematic approach consisting of evaluating the unit cell, then assessing the number of periods needed, and finally characterizing the response of the final sensor was followed for each case. After the modeling process was

  4. Conclusion statement of the 'gas tariffs' Commission works

    International Nuclear Information System (INIS)

    2006-01-01

    This report recalls some basic aspects of gas economy, notices that gas purchase prices are indexed to oil product prices, compares gas prices among European countries, briefly evokes the competition situation on the gas market in France, indicates the field of application of tariffs fixed by the ministry and the different pricing regimes, briefly discusses the pricing modalities, indicates the different components of gas price for a typical user. Then, recommendations are formulated for a new gas pricing policy based on true prices, transparency and user expectations

  5. Preliminary estimation of infantile exposure to BPA based on the standard quality of baby bottles distributed in Isfahan urban society

    Directory of Open Access Journals (Sweden)

    Zohreh Abdi Moghadam

    2013-01-01

    Full Text Available Aims: This study was aimed to estimate the bisphenol A (BPA intake from baby bottles, considering the diversity and the standard quality of the baby bottles distributed in an Isfahan urban society. Materials and Methods: A cross-sectional study was performed in Isfahan in 2011. Baby shops ( n = 33 and drug stores ( n = 7 in four district areas were included in the study. The distribution of baby bottles was investigated regarding their brand, origin, and being labeled "BPA free." Estimation of exposure to BPA from baby bottles was made based on the national and international representative data. Results: The products marked as "BPA free" were found among the western products and limited to two of the selected areas. No "BPA free" marked baby bottle was distinguished among the Iranian made products. Of the 8% exclusively formula-fed infants, 90% may be the high consumers of BPA from polycarbonate baby bottles, with an intake of 1.5-2 μg/kg b.w./day for the moderate and 7.5-10 μg/kg b.w./day in case of worse condition. Conclusion: Considering the current globally accepted threshold daily intake (TDI for BPA, primary exposure estimation is that feeding using non-BPA-free baby bottles is not a serious health concern in Iran. Thought that threshold level of TDI is discussed to be reduced in future, improvement and revision of the national standards can be effective in reducing the exposure to BPA in Iranian infants so as to provide large margin of safety for them.

  6. Preliminary research on the identification system for anthracnose and powdery mildew of sandalwood leaf based on image processing.

    Directory of Open Access Journals (Sweden)

    Chunyan Wu

    Full Text Available This paper presents a survey on a system that uses digital image processing techniques to identify anthracnose and powdery mildew diseases of sandalwood from digital images. Our main objective is researching the most suitable identification technology for the anthracnose and powdery mildew diseases of the sandalwood leaf, which provides algorithmic support for the real-time machine judgment of the health status and disease level of sandalwood. We conducted real-time monitoring of Hainan sandalwood leaves with varying severity levels of anthracnose and powdery mildew beginning in March 2014. We used image segmentation, feature extraction and digital image classification and recognition technology to carry out a comparative experimental study for the image analysis of powdery mildew, anthracnose disease and healthy leaves in the field. Performing the actual test for a large number of diseased leaves pointed to three conclusions: (1 Distinguishing effects of BP (Back Propagation neural network method, in all kinds of classical methods, for sandalwood leaf anthracnose and powdery mildew disease are relatively good; the size of the lesion areas were closest to the actual. (2 The differences between two diseases can be shown well by the shape feature, color feature and texture feature of the disease image. (3 Identifying and diagnosing the diseased leaves have ideal results by SVM, which is based on radial basis kernel function. The identification rate of the anthracnose and healthy leaves was 92% respectively, and that of powdery mildew was 84%. Disease identification technology lays the foundation for remote monitoring disease diagnosis, preparing for remote transmission of the disease images, which is a very good guide and reference for further research of the disease identification and diagnosis system in sandalwood and other species of trees.

  7. Preliminary research on the identification system for anthracnose and powdery mildew of sandalwood leaf based on image processing.

    Science.gov (United States)

    Wu, Chunyan; Wang, Xuefeng

    2017-01-01

    This paper presents a survey on a system that uses digital image processing techniques to identify anthracnose and powdery mildew diseases of sandalwood from digital images. Our main objective is researching the most suitable identification technology for the anthracnose and powdery mildew diseases of the sandalwood leaf, which provides algorithmic support for the real-time machine judgment of the health status and disease level of sandalwood. We conducted real-time monitoring of Hainan sandalwood leaves with varying severity levels of anthracnose and powdery mildew beginning in March 2014. We used image segmentation, feature extraction and digital image classification and recognition technology to carry out a comparative experimental study for the image analysis of powdery mildew, anthracnose disease and healthy leaves in the field. Performing the actual test for a large number of diseased leaves pointed to three conclusions: (1) Distinguishing effects of BP (Back Propagation) neural network method, in all kinds of classical methods, for sandalwood leaf anthracnose and powdery mildew disease are relatively good; the size of the lesion areas were closest to the actual. (2) The differences between two diseases can be shown well by the shape feature, color feature and texture feature of the disease image. (3) Identifying and diagnosing the diseased leaves have ideal results by SVM, which is based on radial basis kernel function. The identification rate of the anthracnose and healthy leaves was 92% respectively, and that of powdery mildew was 84%. Disease identification technology lays the foundation for remote monitoring disease diagnosis, preparing for remote transmission of the disease images, which is a very good guide and reference for further research of the disease identification and diagnosis system in sandalwood and other species of trees.

  8. CSNI/NEA Rasplav seminar 2000. Summary and conclusions

    International Nuclear Information System (INIS)

    2001-01-01

    various boundary conditions were investigated. The work involved a combination of integral and separate effect tests including molten-salt tests to investigate non-eutectic mixtures and the effects of stratification, extension of the material property database to allow interpretation and modelling of the experimental data. The CSNI decided to hold a seminar where the major outcome of the RASPLAV Project could be presented and discussed also in the context of other experienced activities on Severe Accidents. The objectives of the seminar are: - to review the experimental results of the RASPLAV Project; - to exchange information on complementary research; - to discuss the progress made on understanding severe accident progression; - to discuss the applicability to nuclear power plants and use of the results. The Seminar was intended to provide an in-depth review of the RASPLAV Project in terms of the technical capabilities, results and analyses produced during the project execution. The application of the results and their significance for power plant applications were addressed. Relevant results of the complementary research carried out at various laboratories were also presented. The seminar consisted of five sessions organised as follows: - Opening and overview; - Experimental results; - Theoretical Analyses; - Application and complementary research; - Conclusion

  9. CSNI/NEA Rasplav seminar 2000. Summary and conclusions

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-01-15

    various boundary conditions were investigated. The work involved a combination of integral and separate effect tests including molten-salt tests to investigate non-eutectic mixtures and the effects of stratification, extension of the material property database to allow interpretation and modelling of the experimental data. The CSNI decided to hold a seminar where the major outcome of the RASPLAV Project could be presented and discussed also in the context of other experienced activities on Severe Accidents. The objectives of the seminar are: - to review the experimental results of the RASPLAV Project; - to exchange information on complementary research; - to discuss the progress made on understanding severe accident progression; - to discuss the applicability to nuclear power plants and use of the results. The Seminar was intended to provide an in-depth review of the RASPLAV Project in terms of the technical capabilities, results and analyses produced during the project execution. The application of the results and their significance for power plant applications were addressed. Relevant results of the complementary research carried out at various laboratories were also presented. The seminar consisted of five sessions organised as follows: - Opening and overview; - Experimental results; - Theoretical Analyses; - Application and complementary research; - Conclusion.

  10. Structural aging program -- a summary of activities, results, and conclusions

    International Nuclear Information System (INIS)

    Naus, D.J.; Oland, C.B.; Ellingwood, B.R.

    1997-01-01

    Research has been conducted by the Oak Ridge National Laboratory to address aging management of nuclear power plant concrete structures. The purpose was to identify potential structural safety issues and acceptance criteria for use in continued service assessments. Primary program accomplishments have included formulation of a Structural Materials Information Center that contains data and information on the time variation of material properties under the influence of pertinent environmental stressors and aging factors for 144 materials, an aging assessment methodology to identify critical structures and degradation factors that can potentially impact their performance, guidelines and evaluation criteria for use in condition assessments of reinforced concrete structures, and a reliability-based methodology for current condition assessments and estimations of future performance of reinforced concrete nuclear power plant structures. In addition, the Structural Aging Program conducted in-depth evaluations of several nondestructive evaluation and repair-related technologies to develop guidance on their applicability

  11. SYNTAXOMOMICAL SURVEY O F EUROPEAN BEECH FORESTS: SOME GENERAL CONCLUSIONS

    Directory of Open Access Journals (Sweden)

    H. DIERSCHKE

    1997-01-01

    Full Text Available A short overwiev is given about the historical development of syntaxonomy of European beech forests. Different solutions of classification have been proposed, following more or less two main approaches: Division of alliances and suballiances by ecologically or geographically orientated species groups. A new classification of European beech forests is proposed with 8 (or more geographically orientated alliances, which can be further divided into suballiances by ecological species groups. For each alliance character and differential species, nomenclatural type and the area is mentioned, based on a (non puplished synthetic table, including 10.006 relevés from all parts of Europe. From this table also some overlapping species groups (a-n are given.

  12. Preliminary results of sup(40)Ca(e,e'c) reaction analysis c p,α, based on statistical model

    International Nuclear Information System (INIS)

    Herdade, S.B.; Emrich, H.J.

    1990-01-01

    Statistical model calculations relative to the reactions sup(40)Ca (e,e'p) sup(39)K and sup(40)Ca(e,e'P sub(o)) sup(39)K sup(gs), using a modified version of the program STAPRE are compared with experimental results obtained from coincidence experiments carried out at the Mainz microtron MAMI A. Preliminary results indicate that the statistical decay of a 1 sup(-) level in the sup(40)Ca compound nucleus, at an excitation energy + 20 MeV, to the ground state of the sup(39)K residual nucleus is only about 15% of the total decay, indicating that direct and/or semi-direct mechanisms contribute to the major part of the decay. (author)

  13. Xi. Sleep and development: conclusions and future directions.

    Science.gov (United States)

    Sadeh, Avi; El-Sheikh, Mona

    2015-03-01

    Literature on sleep and child development is growing in novel directions across several disciplines necessitating guiding conceptual principles and methodological tools. First, this volume presents a summary of discussions from an SRCD-sponsored multidisciplinary forum on sleep and development, which includes presentation of key issues and guiding recommendations for research priorities in this fast developing field. Second, enhancing accessibility to child development researchers, state of the science sleep assessment methodologies are presented with a discussion of their advantages and disadvantages. Third, seven empirical studies conducted with "typically" developing infants and children provide examples of relations between sleep and some of the many individual and familial factors that influence and are influenced by sleep. In the presentation of empirical findings, a developmental ecological systems perspective adapted to sleep was espoused to illustrate some of the multiple levels of influence in the study of child sleep and development. Collectively, studies in this volume build significantly on the literature through: (a) illustrating linkages between various sleep parameters (e.g., quality, sleeping arrangements) and other key developmental domains (e.g., attachment, parenting); (b) demonstration of longitudinal relations connecting sleep with development, which is scarce in this field; and (c) utilization of actigraphy-based assessments of sleep duration and quality, which are underutilized in the literature yet important for a more nuanced understanding of sleep and development. © 2015 The Society for Research in Child Development, Inc.

  14. Preliminary findings of an adapted evidence-based woman-focused HIV intervention on condom use and negotiation among at-risk women in Pretoria, South Africa.

    Science.gov (United States)

    Wechsberg, Wendee M; Luseno, Winnie K; Kline, Tracy L; Browne, Felicia A; Zule, William A

    2010-01-01

    This article presents the results of a randomized trial in South Africa of an adapted evidence-based Woman-Focused intervention on condom use with primary sex partners. The preliminary findings show that regardless of HIV status, condom negotiation was significantly associated with condom use at the 3- and 6-month follow-ups. By intervention group, significant intervention effects were found at 6-month follow-up for HIV-positive and HIV-unknown status women in the Woman-Focused intervention who were more likely than women in the Standard intervention to report condom use with a primary male partner. Among HIV-positive women, those in the Woman-Focused group and those with greater sexual control were more likely to report condom use at the 6-month follow-up. The findings indicate that gender-based interventions for women may result in increased condom negotiation skills.

  15. Northern Canada in a Changing Climate: Major Findings and Conclusions

    Energy Technology Data Exchange (ETDEWEB)

    Prowse, Terry D.; Peters, Daniel L. (Water and Climate Impacts Research Centre, Environment Canada, Dept. of Geography, Univ. of Victoria, Victoria, BC (Canada)). e-mail: terry.prowse@ec.gc.caa; Furgal, Chris (Indigenous Environmental Studies Program, Trent Univ., Peterborough, ON (Canada))

    2009-07-15

    Key findings include: Climate-induced changes in the cryosphere have large implications for infrastructure maintenance and design. Much of the infra-structure in the North is dependent upon the cryosphere to, for example, provide stable surfaces for buildings and pipelines, contain wastes, stabilize shorelines, and provide access to remote communities in the winter. Permafrost warming and thaw may require remedial action or further engineering modifications to existing infrastructure. Waste retention ponds and lakes that rely on the impervious nature of permafrost to retain environmentally hazardous materials are a particular concern. In the longer term, marine and freshwater transportation will need to shift its reliance from ice routes to open-water or land-based transport systems. Coastal areas and communities will also become more vulnerable to erosion with loss of sea ice compounded with increased storminess and rising sea levels. Changes in the timing of river flows will require modifications to the infrastructure and flow strategies used in generating hydroelectricity. As the climate continues to change, there will be consequences for biodiversity shifts and in ranges and distribution of many species with impacts on availability, accessibility, and quality of resources upon which human populations rely. The northward migration of species, and disruption and competition from invading species, are already occurring and will continue to alter terrestrial and aquatic communities. Shifting environmental conditions will likely introduce new animal transmitted diseases and redistribute some existing diseases, affecting key economic resources and some human populations. Stress on populations of iconic wildlife species will likely continue as a result of changes to critical sea-ice habitat. Where these stresses affect economically or culturally important species, they will have significant impacts on people and regional economies. Increased navigability of Arctic

  16. Workshop observations, conclusions, and recommendations for moving forward

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    Bangkok currently has enormous numbers of motorised vehicles. The number of motor vehicles registered in Bangkok in 1993 was about 2.6 million of which over 1 million were cars and around 1.1 million were motorcycles. The vehicle population is noticeably increasing at about 12% over the previous year, despite the traffic congestion which is nearly at gridlock. Overall average traffic speed in the Bangkok metropolitan area is around 10 km/h. However, during peak hours on some main roads in the central business area, the crawl rate is at 1-2 km/h, or only half walking pace. There are, however, several circumstances to be addressed before Bangkok can begin to overcome its air quality and congestion problems. The first is that many of the city`s transport planners that design transport projects, and the policymakers with investment authority appear to be caught in the same conventional transport planning paradigm as many other industrializing and industrialized countries. That paradigm, pioneered in the United States and exported to much of the world, defines the problems as a shortage of road space to meet demand for, private, vehicular mobility. The investment focus is almost exclusively on the construction of large road-based infrastructure to machines instead of people, while de-emphasizing other forms of transport such as rail, water, and non-motorized transport - even if they are a less expensive investment that can meet demand. The predominance of this paradigm results in a persistent myth held by many of Bangkok`s policymakers, transport and urban planners, financiers, and citizens. The myth is that the city does not have enough kilometers of roadways per person, and should focus on road and highway investment in order to solve their air quality and congestion problems.

  17. OECD/SERENA Project Report. Summary and Conclusions

    International Nuclear Information System (INIS)

    2015-02-01

    involving nominally 20 kilograms of prototypic melt. The analytical programme was aimed at complementing the analytical work in WGAMA/SERENA activity, completed in 2006, by integrating the results of the experimental programme in the current phase, and by updating the capabilities of the FCI models/codes for use in reactor safety analysis. The scope of the reactor application exercise was to verify whether progress made in the SERENA programme in understanding and modelling key FCI phenomena for reactor applications (mainly phenomena related to premixing, e.g., jet fragmentation, voiding, melt solidification, etc., as well as the role of melt properties) contributed to a reduction of scatter in code predictions for ex-vessel FCI, observed in the WGAMA/SERENA activity. A better consistency of the results was noted between various FCI codes although some discrepancies still exist on the absolute values. The scatter in most 2-D simulations is more due to the ultimate choice of the parameters (e.g., fragmentation criteria in the explosion phase) than to fundamental differences in the physics. This discrepancy will reduce further when the codes will have improved models based on the new experimental data produced in the project. Note the current experimental data have not been fully capitalised yet; accordingly, it will take some time to improve the models. The OECD/SERENA project accomplished in large part its stated objectives. The project generated new experimental data for development of new phenomenological models closed to real reactor case conditions (corium composition), improvement of existing models, and assessment of FCI codes. The project also provided new insights; however, it would be sometime before the insights can be fully integrated into new and improved models and codes. It should be noted that the FCI models and codes can only be as precise as the experimental data and that there are inherent uncertainties in experimental data. While from a regulatory and

  18. Spot Scanning Proton Therapy for Malignancies of the Base of Skull: Treatment Planning, Acute Toxicities, and Preliminary Clinical Outcomes

    Energy Technology Data Exchange (ETDEWEB)

    Grosshans, David R., E-mail: dgrossha@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Zhu, X. Ronald; Melancon, Adam [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Allen, Pamela K. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Poenisch, Falk; Palmer, Matthew [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); McAleer, Mary Frances; McGovern, Susan L. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Gillin, Michael [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); DeMonte, Franco [Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Chang, Eric L. [Department of Radiation Oncology, University of Southern California Keck School of Medicine, Los Angeles, California (United States); Brown, Paul D.; Mahajan, Anita [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2014-11-01

    Purpose: To describe treatment planning techniques and early clinical outcomes in patients treated with spot scanning proton therapy for chordoma or chondrosarcoma of the skull base. Methods and Materials: From June 2010 through August 2011, 15 patients were treated with spot scanning proton therapy for chordoma (n=10) or chondrosarcoma (n=5) at a single institution. Toxicity was prospectively evaluated and scored weekly and at all follow-up visits according to Common Terminology Criteria for Adverse Events, version 3.0. Treatment planning techniques and dosimetric data were recorded and compared with those of passive scattering plans created with clinically applicable dose constraints. Results: Ten patients were treated with single-field-optimized scanning beam plans and 5 with multifield-optimized intensity modulated proton therapy. All but 2 patients received a simultaneous integrated boost as well. The mean prescribed radiation doses were 69.8 Gy (relative biological effectiveness [RBE]; range, 68-70 Gy [RBE]) for chordoma and 68.4 Gy (RBE) (range, 66-70) for chondrosarcoma. In comparison with passive scattering plans, spot scanning plans demonstrated improved high-dose conformality and sparing of temporal lobes and brainstem. Clinically, the most common acute toxicities included fatigue (grade 2 for 2 patients, grade 1 for 8 patients) and nausea (grade 2 for 2 patients, grade 1 for 6 patients). No toxicities of grades 3 to 5 were recorded. At a median follow-up time of 27 months (range, 13-42 months), 1 patient had experienced local recurrence and a second developed distant metastatic disease. Two patients had magnetic resonance imaging-documented temporal lobe changes, and a third patient developed facial numbness. No other subacute or late effects were recorded. Conclusions: In comparison to passive scattering, treatment plans for spot scanning proton therapy displayed improved high-dose conformality. Clinically, the treatment was well tolerated, and

  19. Psycho-physiological assessment of a prosthetic hand sensory feedback system based on an auditory display: a preliminary study

    Directory of Open Access Journals (Sweden)

    Gonzalez Jose

    2012-06-01

    Full Text Available Abstract Background Prosthetic hand users have to rely extensively on visual feedback, which seems to lead to a high conscious burden for the users, in order to manipulate their prosthetic devices. Indirect methods (electro-cutaneous, vibrotactile, auditory cues have been used to convey information from the artificial limb to the amputee, but the usability and advantages of these feedback methods were explored mainly by looking at the performance results, not taking into account measurements of the user’s mental effort, attention, and emotions. The main objective of this study was to explore the feasibility of using psycho-physiological measurements to assess cognitive effort when manipulating a robot hand with and without the usage of a sensory substitution system based on auditory feedback, and how these psycho-physiological recordings relate to temporal and grasping performance in a static setting. Methods 10 male subjects (26+/-years old, participated in this study and were asked to come for 2 consecutive days. On the first day the experiment objective, tasks, and experiment setting was explained. Then, they completed a 30 minutes guided training. On the second day each subject was tested in 3 different modalities: Auditory Feedback only control (AF, Visual Feedback only control (VF, and Audiovisual Feedback control (AVF. For each modality they were asked to perform 10 trials. At the end of each test, the subject had to answer the NASA TLX questionnaire. Also, during the test the subject’s EEG, ECG, electro-dermal activity (EDA, and respiration rate were measured. Results The results show that a higher mental effort is needed when the subjects rely only on their vision, and that this effort seems to be reduced when auditory feedback is added to the human-machine interaction (multimodal feedback. Furthermore, better temporal performance and better grasping performance was obtained in the audiovisual modality. Conclusions The performance

  20. [Conclusions. The precautionary principle: its advantages and risks].

    Science.gov (United States)

    Tubiana, M

    2000-01-01

    The proposed extension to health of the precautionary principle is the reaction to two social demands: the desire for greater health safety and for more transparency in the decision making process by associating the public. In medical care, all decisions are based on the balance between cost (dangers induced by the treatment) and benefit (the therapeutic effect). It is as dangerous to overestimate the cost, in other words the risks, as it is to underestimate them. The same problem is encountered in public health. If a vaccination is to be prescribed, the beneficial effects must outweigh the risks; however, these risks are inevitable and have been known to exist since the 18th century, but they have been accepted for the public good. It takes courage to make a vaccination mandatory because those who benefit from it will never know, while those who suffer from its ill effects could take legal action. In order to counter accusations, an evaluation must be made beforehand of the risks and benefits, which underlines the important role of expert opinion. Within the framework of the precautionary principle, actions cannot be taken in ignorance and, at the very least, plausible estimations must be made. The analysis of several recent events (contaminated blood, BSE, growth hormone and Creutzfeldt-Jacob disease) shows that the precautionary principle would have had a very limited impact and that only once there was sufficient knowledge was action made possible. The same is true concerning current debates (the possible risks associated with electromagnetic fields, mobile phones and radon); in these three cases, no country in the world has invoked the precautionary principle, but rather the priority has been given to research. The public understands quite readily the cost/benefit relationship. In the case of oral contraceptives, or hormone replacement therapy the public was aware of their possible health risks but judged that the advantages outweighed the risks. The

  1. Preliminary safety evaluation for the Laxemar subarea. Based on data and site descriptions after the initial site investigation stage

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, Johan [JA Streamflow AB, Aelvsjoe (Sweden)

    2006-03-15

    The main objectives of this Preliminary Safety Evaluation (PSE) of the Laxemar subarea have been to determine, with limited efforts, whether the feasibility study's judgement of the suitability of the candidate area with respect to long-term safety holds up in the light of the actual site investigation data; to provide feedback to continued site investigations and site-specific repository design and to identify site-specific scenarios and geoscientific issues for further analyses. The PSE focuses on comparing the attained knowledge of the sites with the suitability criteria as set out by SKB in 2000. These criteria both concern properties of the site judged to be necessary for safety and engineering (requirements) and properties judged to be beneficial (preferences). The findings are then evaluated in order to provide feedback to continued investigations and design work. The PSE does not aim at comparing sites and does not assess compliance with safety and radiation protection criteria. The latter is eventually done in coming Safety Assessments. This preliminary safety evaluation shows that, according to existing data, the Laxemar subarea meets all safety requirements. The evaluation also shows that the Laxemar subarea meets most of the safety preferences, but for some aspects of the site description further reduction of the uncertainties would enhance the safety case. Despite the stated concerns, there is no reason, from a safety point of view, not to continue the Site Investigations at the Laxemar subarea. There are uncertainties to resolve and the safety would eventually need to be verified through a proper safety assessment. Only some of the uncertainties noted in the Site Descriptive Model have safety implications and need further resolution for this reason. Furthermore, uncertainties may need resolving for other reasons, such as giving an adequate assurance of site understanding or assisting in optimising design. Notably, there are questions about the

  2. Preliminary safety evaluation for the Laxemar subarea. Based on data and site descriptions after the initial site investigation stage

    International Nuclear Information System (INIS)

    Andersson, Johan

    2006-03-01

    The main objectives of this Preliminary Safety Evaluation (PSE) of the Laxemar subarea have been to determine, with limited efforts, whether the feasibility study's judgement of the suitability of the candidate area with respect to long-term safety holds up in the light of the actual site investigation data; to provide feedback to continued site investigations and site-specific repository design and to identify site-specific scenarios and geoscientific issues for further analyses. The PSE focuses on comparing the attained knowledge of the sites with the suitability criteria as set out by SKB in 2000. These criteria both concern properties of the site judged to be necessary for safety and engineering (requirements) and properties judged to be beneficial (preferences). The findings are then evaluated in order to provide feedback to continued investigations and design work. The PSE does not aim at comparing sites and does not assess compliance with safety and radiation protection criteria. The latter is eventually done in coming Safety Assessments. This preliminary safety evaluation shows that, according to existing data, the Laxemar subarea meets all safety requirements. The evaluation also shows that the Laxemar subarea meets most of the safety preferences, but for some aspects of the site description further reduction of the uncertainties would enhance the safety case. Despite the stated concerns, there is no reason, from a safety point of view, not to continue the Site Investigations at the Laxemar subarea. There are uncertainties to resolve and the safety would eventually need to be verified through a proper safety assessment. Only some of the uncertainties noted in the Site Descriptive Model have safety implications and need further resolution for this reason. Furthermore, uncertainties may need resolving for other reasons, such as giving an adequate assurance of site understanding or assisting in optimising design. Notably, there are questions about the

  3. A preliminary evaluation of the training effects of a didactic and simulation-based psychological first aid program in students and school counselors in South Korea.

    Science.gov (United States)

    Lee, Jong-Sun; You, Sungeun; Choi, Yun-Kyeung; Youn, Hyae-Young; Shin, Hye Sook

    2017-01-01

    The present study aimed to examine the training effects of a didactic and simulation-based psychological first aid (PFA) program. Based on the competency-based model, the study sought to examine whether the PFA training would enhance knowledge, skills, and attitudes. Study 1 examined the training effects of the PFA program in a sample of undergraduate and graduate students in psychology. Study 2 was conducted with school counselors. In both studies, all participants completed a one-day PFA workshop with a 3-hour didactic lecture and a 3-hour simulation-based practice. Assessments were conducted prior to the didactic lecture and upon completion of the simulation-based practice. In study 1, an examination of pre- and posttest comparisons indicated that the training significantly improved students' PFA knowledge and perceived competence in PFA skill. In study 2, the same PFA training significantly improved school counselors' PFA knowledge, perceived competence in PFA skill, perceived preparedness and confidence to provide psychological assistance for future disasters, but their perceived willingness to participate in psychological assistance did not significantly change after the training. This study provides preliminary evidence supporting the effectiveness of the PFA training program using a combined method of didactic and simulation-based practice for disaster mental health providers in Korea.

  4. A preliminary evaluation of the training effects of a didactic and simulation-based psychological first aid program in students and school counselors in South Korea.

    Directory of Open Access Journals (Sweden)

    Jong-Sun Lee

    Full Text Available The present study aimed to examine the training effects of a didactic and simulation-based psychological first aid (PFA program. Based on the competency-based model, the study sought to examine whether the PFA training would enhance knowledge, skills, and attitudes. Study 1 examined the training effects of the PFA program in a sample of undergraduate and graduate students in psychology. Study 2 was conducted with school counselors. In both studies, all participants completed a one-day PFA workshop with a 3-hour didactic lecture and a 3-hour simulation-based practice. Assessments were conducted prior to the didactic lecture and upon completion of the simulation-based practice. In study 1, an examination of pre- and posttest comparisons indicated that the training significantly improved students' PFA knowledge and perceived competence in PFA skill. In study 2, the same PFA training significantly improved school counselors' PFA knowledge, perceived competence in PFA skill, perceived preparedness and confidence to provide psychological assistance for future disasters, but their perceived willingness to participate in psychological assistance did not significantly change after the training. This study provides preliminary evidence supporting the effectiveness of the PFA training program using a combined method of didactic and simulation-based practice for disaster mental health providers in Korea.

  5. 5. Conclusion

    OpenAIRE

    Beerli, Monique Jo

    2013-01-01

    Attracted by conflict and war, starvation and disease, natural disasters and underdevelopment, discrimination and injustice, solidarity organizations and their supporters engage themselves in struggles for the acquisition of benefits that they themselves will not receive. In the absence of political solutions addressing the demands of a given people, non-state actors are capable of appropriating functions and responsibilities upon themselves which the state is unwilling or unable to perform. ...

  6. Conclusion conference

    International Nuclear Information System (INIS)

    Tubiana, M.

    1997-01-01

    Radioactive isotopes are the basis of spectacular advancements in biology, but also in medicine, not only indirectly with progress in disease and human body understanding, but also directly through nuclear medicine and radiotherapy. The important role of the Cea in the development of French radiotherapy, dosimetry and radioactive isotopes (especially cobalt) is reviewed

  7. Estimation of past sea-level variations based on ground-penetrating radar mapping of beach-ridges - preliminary results from Feddet, Faxe Bay, eastern Denmark

    DEFF Research Database (Denmark)

    Hede, Mikkel Ulfeldt; Nielsen, Lars; Clemmensen, Lars B

    2011-01-01

    Estimates of past sea-level variations based on different methods and techniques have been presented in a range of studies, including interpretation of beach ridge characteristics. In Denmark, Holocene beach ridge plains have been formed during the last c. 7700 years, a period characterised by both...... isostatic uplift and changes in eustatic sea-level, and therefore represent an archive of past relative sea-level variations. Here, we present preliminary results from investigation of beach ridges from Feddet, a small peninsula located in Faxe Bay (Baltic Sea) in the eastern part of Denmark. Feddet has...... been chosen as a key-locality in this project, as it is located relatively close to the current 0-isobase of isostatic rebound. GPR reflection data have been acquired with shielded 250 MHz Sensors & software antennae along a number of profile lines across beach ridge and swale structures of the Feddet...

  8. Development of a tissue-engineered human oral mucosa equivalent based on an acellular allogeneic dermal matrix: a preliminary report of clinical application to burn wounds.

    Science.gov (United States)

    Iida, Takuya; Takami, Yoshihiro; Yamaguchi, Ryo; Shimazaki, Shuji; Harii, Kiyonori

    2005-01-01

    Tissue-engineered skin equivalents composed of epidermal and dermal components have been widely investigated for coverage of full-thickness skin defects. We developed a tissue-engineered oral mucosa equivalent based on an acellular allogeneic dermal matrix and investigated its characteristics. We also tried and assessed its preliminary clinical application. Human oral mucosal keratinocytes were separated from a piece of oral mucosa and cultured in a chemically-defined medium. The keratinocytes were seeded on to the acellular allogeneic dermal matrix and cultured. Histologically, the mucosa equivalent had a well-stratified epithelial layer. Immunohistochemical study showed that it was similar to normal oral mucosa. We applied this equivalent in one case with an extensive burn wound. The equivalent was transplanted three weeks after the harvest of the patient's oral mucosa and about 30% of the graft finally survived. We conclude that this new oral mucosa equivalent could become a therapeutic option for the treatment of extensive burns.

  9. Development of Nordic Standard for analysis of oil and fat in water based on supercritical fluid extraction. Preliminary study, part 2

    International Nuclear Information System (INIS)

    Jenssen, L.

    1994-06-01

    This report describes a preliminary study of a method of determining oil in water. The method is based on solid phase extraction and supercritical fluid extraction (SPE-SFE). The oil is extracted from the water by absorption to extraction disks from which it is then desorbed by supercritical carbon dioxide and detected by means of infrared spectrophotometry or gas chromatography. The results of the study will indicate if the method is suitable as a future substitute for the present Norwegian Standard, NS 9803 (Swedish Standard, SS 02 8145). The method has been validated using water samples with addition of real oil to 1-100 ppm. The accuracy is almost 70%, and the method has good repeatability and is linear in the 1-100 ppm range. 5 refs., 6 figs., 10 tabs

  10. Comparison of a Web-Based Teaching Tool and Traditional Didactic Learning for In Vitro Fertilization Patients: A Preliminary Randomized Controlled Trial.

    Science.gov (United States)

    Vause, Tannys Dawn Reiko; Allison, David J; Vause, Tricia; Tekok-Kilic, Ayda; Ditor, David S; Min, Jason K

    2018-05-01

    The objective of this prospective RCT was to compare the efficacy of a web-based teaching tool to traditional didactic teaching in IVF patients. Forty women undergoing their first IVF cycle were randomly allocated to an interactive web-based teaching session or a nurse-led didactic teaching session. The primary outcome measure was participant knowledge regarding the IVF process, risks, and logistics assessed before and after the respective teaching session. Secondary outcomes included patient stress, assessed before and after the respective teaching session, and patient satisfaction, assessed following the respective teaching session and on the day of embryo transfer (following implementation of the teaching protocol). Both groups demonstrated similar and significant improvements in knowledge and stress after exposure to their respective teaching sessions. The web-based group was significantly more satisfied than the didactic teaching group. Web-based teaching was also shown to be equally effective for participants of high versus low income and education status for knowledge, stress, and satisfaction. This study provides preliminary support for the use of web-based teaching as an equally effective tool for increasing knowledge and reducing stress compared to traditional didactic teaching in IVF patients, with the added benefit of increased patient satisfaction. Copyright © 2018 Society of Obstetricians and Gynaecologists of Canada. Published by Elsevier Inc. All rights reserved.

  11. A text-based data mining and toxicity prediction modeling system for a clinical decision support in radiation oncology: A preliminary study

    Science.gov (United States)

    Kim, Kwang Hyeon; Lee, Suk; Shim, Jang Bo; Chang, Kyung Hwan; Yang, Dae Sik; Yoon, Won Sup; Park, Young Je; Kim, Chul Yong; Cao, Yuan Jie

    2017-08-01

    The aim of this study is an integrated research for text-based data mining and toxicity prediction modeling system for clinical decision support system based on big data in radiation oncology as a preliminary research. The structured and unstructured data were prepared by treatment plans and the unstructured data were extracted by dose-volume data image pattern recognition of prostate cancer for research articles crawling through the internet. We modeled an artificial neural network to build a predictor model system for toxicity prediction of organs at risk. We used a text-based data mining approach to build the artificial neural network model for bladder and rectum complication predictions. The pattern recognition method was used to mine the unstructured toxicity data for dose-volume at the detection accuracy of 97.9%. The confusion matrix and training model of the neural network were achieved with 50 modeled plans (n = 50) for validation. The toxicity level was analyzed and the risk factors for 25% bladder, 50% bladder, 20% rectum, and 50% rectum were calculated by the artificial neural network algorithm. As a result, 32 plans could cause complication but 18 plans were designed as non-complication among 50 modeled plans. We integrated data mining and a toxicity modeling method for toxicity prediction using prostate cancer cases. It is shown that a preprocessing analysis using text-based data mining and prediction modeling can be expanded to personalized patient treatment decision support based on big data.

  12. A Preliminary Study on the Efficacy of a Community-Based Physical Activity Intervention on Physical Function-Related Risk Factors for Falls Among Breast Cancer Survivors.

    Science.gov (United States)

    Lee, C Ellen; Warden, Stuart J; Szuck, Beth; Lau, Y K James

    2016-08-01

    The aim of this study was to examine the effects of a 6-week community-based physical activity (PA) intervention on physical function-related risk factors for falls among 56 breast cancer survivors (BCS) who had completed treatments. This was a single-group longitudinal study. The multimodal PA intervention included aerobic, strengthening, and balance components. Physical function outcomes based on the 4-meter walk, chair stand, one-leg stance, tandem walk, and dynamic muscular endurance tests were assessed at 6-week pre-intervention (T1), baseline (T2), and post-intervention (T3). T1 to T2 and T2 to T3 were the control and intervention periods, respectively. All outcomes, except the tandem walk test, significantly improved after the intervention period (P control period (P > 0.05). Based on the falls risk criterion in the one-leg stance test, the proportion at risk for falls was significantly lower after the intervention period (P = 0.04), but not after the control period. A community-based multimodal PA intervention for BCS may be efficacious in improving physical function-related risk factors for falls, and lowering the proportion of BCS at risk for falls based on specific physical function-related falls criteria. Further larger trials are needed to confirm these preliminary findings.

  13. A Nonlinear Dynamics-Based Estimator for Functional Electrical Stimulation: Preliminary Results From Lower-Leg Extension Experiments.

    Science.gov (United States)

    Allen, Marcus; Zhong, Qiang; Kirsch, Nicholas; Dani, Ashwin; Clark, William W; Sharma, Nitin

    2017-12-01

    Miniature inertial measurement units (IMUs) are wearable sensors that measure limb segment or joint angles during dynamic movements. However, IMUs are generally prone to drift, external magnetic interference, and measurement noise. This paper presents a new class of nonlinear state estimation technique called state-dependent coefficient (SDC) estimation to accurately predict joint angles from IMU measurements. The SDC estimation method uses limb dynamics, instead of limb kinematics, to estimate the limb state. Importantly, the nonlinear limb dynamic model is formulated into state-dependent matrices that facilitate the estimator design without performing a Jacobian linearization. The estimation method is experimentally demonstrated to predict knee joint angle measurements during functional electrical stimulation of the quadriceps muscle. The nonlinear knee musculoskeletal model was identified through a series of experiments. The SDC estimator was then compared with an extended kalman filter (EKF), which uses a Jacobian linearization and a rotation matrix method, which uses a kinematic model instead of the dynamic model. Each estimator's performance was evaluated against the true value of the joint angle, which was measured through a rotary encoder. The experimental results showed that the SDC estimator, the rotation matrix method, and EKF had root mean square errors of 2.70°, 2.86°, and 4.42°, respectively. Our preliminary experimental results show the new estimator's advantage over the EKF method but a slight advantage over the rotation matrix method. However, the information from the dynamic model allows the SDC method to use only one IMU to measure the knee angle compared with the rotation matrix method that uses two IMUs to estimate the angle.

  14. Preliminary Results From a Heavily Instrumented Engine Ice Crystal Icing Test in a Ground Based Altitude Test Facility

    Science.gov (United States)

    Flegel, Ashlie B.; Oliver, Michael J.

    2016-01-01

    Preliminary results from the heavily instrumented ALF502R-5 engine test conducted in the NASA Glenn Research Center Propulsion Systems Laboratory are discussed. The effects of ice crystal icing on a full scale engine is examined and documented. This same model engine, serial number LF01, was used during the inaugural icing test in the Propulsion Systems Laboratory facility. The uncommanded reduction of thrust (rollback) events experienced by this engine in flight were simulated in the facility. Limited instrumentation was used to detect icing on the LF01 engine. Metal temperatures on the exit guide vanes and outer shroud and the load measurement were the only indicators of ice formation. The current study features a similar engine, serial number LF11, which is instrumented to characterize the cloud entering the engine, detect/characterize ice accretion, and visualize the ice accretion in the region of interest. Data were acquired at key LF01 test points and additional points that explored: icing threshold regions, low altitude, high altitude, spinner heat effects, and the influence of varying the facility and engine parameters. For each condition of interest, data were obtained from some selected variations of ice particle median volumetric diameter, total water content, fan speed, and ambient temperature. For several cases the NASA in-house engine icing risk assessment code was used to find conditions that would lead to a rollback event. This study further helped NASA develop necessary icing diagnostic instrumentation, expand the capabilities of the Propulsion Systems Laboratory, and generate a dataset that will be used to develop and validate in-house icing prediction and risk mitigation computational tools. The ice accretion on the outer shroud region was acquired by internal video cameras. The heavily instrumented engine showed good repeatability of icing responses when compared to the key LF01 test points and during day-to-day operation. Other noticeable

  15. the Preliminary Research Based on Seismic Signals Generated by Hutubi Transmitting Seismic Station with One Large-volume Airgun Array

    Science.gov (United States)

    Wang, Q.; Su, J.; Wei, Y.; Zhang, W.; Wang, H.; Wang, B.; Ji, Z.

    2017-12-01

    For studying the subsurface structure and its subtle changes, we built the Hutubi transmitting seismic station with one large-volume airgun array at one artificial water pool in the northern segment of Tianshan mountain, where earthquakes occurred frequently. The airgun array consists of six airguns with every airgun capacity of 2000in3, and the artificial water pool with the top diameter of 100m, bottom diameter of 20m and the depth of 18m.We started the regular excitation experiment with the large-volume airgun source every week since June, 2013. Using seismic signals geneated by the Hutubi airgun source, we made the preliminary research on the airgun source, waveform characteristics and the subsurface velocity changes in the northern Tiansh mountain. The results are as follows: The seismic signal exited by the airgun source is characteristic of low-frequency ,and the dominant frequency is in the range of 2 6Hz. The Hutubi transmitting seismic station can continuously generate long-distance detectable and highly repeatable signals, and the correlation coefficient of sigals is greater than 0.95; and the longest propagation distance arrives to 380km, in addition, the 5000-shot stacked sigal using the phase weighted stack technique can be identified in the station, which is about 1300km from the Hutubi transmitting seismic station. Hutubi large-volume airgun source is fitted to detect and monitor the regional-scale subsurface stress state. Applying correlation test method, we measured weak subsurface velocity changes in the northern Tianshan mountain, and found that the several stations, which are within 150km from the the Hutubi transmitting seismic station, appeared 0.1 0.2% relative velocity changes before the Hutubi MS6.2 earthquake on Dec.8, 2016.

  16. Effects of virtual reality-based training with BTs-Nirvana on functional recovery in stroke patients: preliminary considerations.

    Science.gov (United States)

    De Luca, Rosaria; Russo, Margherita; Naro, Antonino; Tomasello, Provvidenza; Leonardi, Simona; Santamaria, Floriana; Desireè, Latella; Bramanti, Alessia; Silvestri, Giuseppe; Bramanti, Placido; Calabrò, Rocco Salvatore

    2018-02-02

    Cognitive impairment occurs frequently in post-stroke patients. This study aimed to determine the effects of a virtual reality training (VRT) with BTs-Nirvana (BTsN) on the recovery of cognitive functions in stroke patients, using the Interactive-Semi-Immersive Program (I-SIP). We enrolled 12 subjects (randomly divided into two groups: experimental group (EG); and control group (CG)), who attended the Laboratory of Robotic and Cognitive Rehabilitation of IRCCS Neurolesi of Messina from January to June 2016. The EG underwent a VRT with BTsN, whereas CG received a standard cognitive treatment. Both the groups underwent the same conventional physiotherapy program. Each treatment session lasted 45 minutes and was repeated three times a week for 8 weeks. All the patients were evaluated by a specific clinical-psychometric battery before (T0), immediately (T1), and one month (T2) after the end of the training. At T1, the EG presented a greater improvement in the trunk control test (p = 0.03), the Montreal Cognitive Assessment (p = 0.01), the selective attention assessment scores (p = 0.01), the verbal memory (p = 0.03), and the visuospatial and constructive abilities (p = 0.01), as compared to CG. Moreover, such amelioration persisted at T2 only in the EG. According to these preliminary data, VRT with I-SIP can be considered a useful complementary treatment to potentiate functional recovery, with regard to attention, visual-spatial deficits, and motor function in patients affected by stroke.

  17. Attitudes of the Japanese public and doctors towards use of archived information and samples without informed consent: Preliminary findings based on focus group interviews

    Directory of Open Access Journals (Sweden)

    Fukuhara Shunichi

    2002-01-01

    Full Text Available Abstract Background The purpose of this study is to explore laypersons' attitudes toward the use of archived (existing materials such as medical records and biological samples and to compare them with the attitudes of physicians who are involved in medical research. Methods Three focus group interviews were conducted, in which seven Japanese male members of the general public, seven female members of the general public and seven physicians participated. Results It was revealed that the lay public expressed diverse attitudes towards the use of archived information and samples without informed consent. Protecting a subject's privacy, maintaining confidentiality, and communicating the outcomes of studies to research subjects were regarded as essential preconditions if researchers were to have access to archived information and samples used for research without the specific informed consent of the subjects who provided the material. Although participating physicians thought that some kind of prior permission from subjects was desirable, they pointed out the difficulties involved in obtaining individual informed consent in each case. Conclusions The present preliminary study indicates that the lay public and medical professionals may have different attitudes towards the use of archived information and samples without specific informed consent. This hypothesis, however, is derived from our focus groups interviews, and requires validation through research using a larger sample.

  18. An integrated gait rehabilitation training based on Functional Electrical Stimulation cycling and overground robotic exoskeleton in complete spinal cord injury patients: Preliminary results.

    Science.gov (United States)

    Mazzoleni, S; Battini, E; Rustici, A; Stampacchia, G

    2017-07-01

    The aim of this study is to investigate the effects of an integrated gait rehabilitation training based on Functional Electrical Stimulation (FES)-cycling and overground robotic exoskeleton in a group of seven complete spinal cord injury patients on spasticity and patient-robot interaction. They underwent a robot-assisted rehabilitation training based on two phases: n=20 sessions of FES-cycling followed by n= 20 sessions of robot-assisted gait training based on an overground robotic exoskeleton. The following clinical outcome measures were used: Modified Ashworth Scale (MAS), Numerical Rating Scale (NRS) on spasticity, Penn Spasm Frequency Scale (PSFS), Spinal Cord Independence Measure Scale (SCIM), NRS on pain and International Spinal Cord Injury Pain Data Set (ISCI). Clinical outcome measures were assessed before (T0) after (T1) the FES-cycling training and after (T2) the powered overground gait training. The ability to walk when using exoskeleton was assessed by means of 10 Meter Walk Test (10MWT), 6 Minute Walk Test (6MWT), Timed Up and Go test (TUG), standing time, walking time and number of steps. Statistically significant changes were found on the MAS score, NRS-spasticity, 6MWT, TUG, standing time and number of steps. The preliminary results of this study show that an integrated gait rehabilitation training based on FES-cycling and overground robotic exoskeleton in complete SCI patients can provide a significant reduction of spasticity and improvements in terms of patient-robot interaction.

  19. A preliminary study of cognitive-behavioral family-based treatment versus parent training for young children with obsessive-compulsive disorder.

    Science.gov (United States)

    Rosa-Alcázar, Ana I; Iniesta-Sepúlveda, Marina; Storch, Eric A; Rosa-Alcázar, Ángel; Parada-Navas, José L; Olivares Rodríguez, José

    2017-01-15

    Cognitive-Behavioral Family-Based Treatment (CBFT) is the standard of care in young children with OCD. Developmental considerations, parent desires, and cost-effective advantages motivate research to explore the relative efficacy of parent-only interventions. The main goal in this study was to test the effectiveness and feasibility of a parent only intervention for OCD in young children, comparing, in a preliminary fashion the relative efficacy of reducing obsessive-compulsive symptoms through two treatment conditions: 1) an individual CBFT for early OCD involving both parents and children, and 2) the family component of the intervention involving only individual Parent Training (PT). Twenty treatment-seeking families from two private outpatient clinics in Spain were alternately assigned to one of the two treatment conditions. Participants had a primary diagnosis of OCD and a mean age of 6.62 years (65% males). Interventions were conducted by the same therapist and the assessments were administered by independent clinicians who were blind to the experimental conditions of the participants. Assessment time-points were pretreatment, posttreatment, and 3-month follow-up (including diagnosis, symptom severity, global functioning, family accommodation, externalizing and internalizing symptoms, and satisfaction measures). The two ways of implementation, involving child and parents (CBFT) or involving only parents (PT), produced clinical improvements and were well-accepted by parents and children. The CBFT condition was superior to the PT condition in reducing externalizing problems. reduced sample size and absence of randomization were the main limitations of this study. these results suggest, in a preliminary manner, that the need to have the child present at session with the clinician could be decreased for some children, as well as the overall feasibility of working only with parents for the implementation of CBT for OCD in very young children. Copyright © 2016

  20. Tritium in precipitation of Vostok (Antarctica): conclusions on the tritium latitude effect.

    Science.gov (United States)

    Hebert, Detlef

    2011-09-01

    During the Antarctic summer of 1985 near the Soviet Antarctic station Vostok, firn samples for tritium measurements were obtained down to a depth of 2.40 m. The results of the tritium measurements are presented and discussed. Based on this and other data, conclusions regarding the tritium latitude effect are derived.

  1. Preliminary Monthly Climatological Summaries

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Preliminary Local Climatological Data, recorded since 1970 on Weather Burean Form 1030 and then National Weather Service Form F-6. The preliminary climate data pages...

  2. Establishment and preliminary application of the interactive tele-radiologic conference system based on virtual private network

    International Nuclear Information System (INIS)

    Wang Xuejian; Hu Jian; Wang Kang; Yu Hui; Luo Min; Lei Wenyong

    2005-01-01

    Objective: To investigate the establishment and characteristics of the interactive tele-radiological system (IATRS). Methods: Local area network (LAN) of local hospitals with firewall and ADSL Modem was connected into internet, then connected into the Virtual Private Network (VPN) server of the affiliated hospital of Guiyang Medical College (GMCAH) through anti-firewall of GMCAH. The VPN tunnel was acquired and LAN of local hospitals was connected into the PACS server of GMCAH, resulting in sharing of radiological data by both the GMCAH and local hospitals. Results: Radiological data from local hospitals could be transmitted by the PACS server of GMCAH safety and rapidly. The IATRS could provide high-quality images with high-speed, and with ease to perform. Conclusion: IATRS is useful and reliable for transmitting radiological data between remote places. (authors)

  3. Benchmark exercises on PWR level-1 PSA (step 3). Analyses of accident sequence and conclusions

    International Nuclear Information System (INIS)

    Niwa, Yuji; Takahashi, Hideaki.

    1996-01-01

    The results of level 1 PSA generate fluctuations due to the assumptions based on several engineering judgements set in the stages of PSA analysis. On the purpose of the investigation of uncertainties due to assumptions, three kinds of a standard problem, what we call benchmark exercise have been set. In this report, sensitivity studies (benchmark exercise) of sequence analyses are treated and conclusions are mentioned. The treatment of inter-system dependency would generate uncertainly of PSA. In addition, as a conclusion of the PSA benchmark exercise, several findings in the sequence analysis together with previous benchmark analyses in earlier INSS Journals are treated. (author)

  4. Technology-Based Communication and the Development of Interpersonal Competencies Within Adolescent Romantic Relationships: A Preliminary Investigation

    Science.gov (United States)

    Nesi, Jacqueline; Widman, Laura; Choukas-Bradley, Sophia; Prinstein, Mitchell J.

    2018-01-01

    This study investigated longitudinal associations between adolescents’ technology-based communication and the development of interpersonal competencies within romantic relationships. A school-based sample of 487 adolescents (58% girls; Mage = 14.1) participated at two time points, one year apart. Participants reported (1) proportions of daily communication with romantic partners via traditional modes (in person, on the phone) versus technological modes (text messaging, social networking sites) and (2) competence in the romantic relationship skill domains of negative assertion and conflict management. Results of cross-lagged panel models indicated that adolescents who engaged in greater proportions of technology-based communication with romantic partners reported lower levels of interpersonal competencies one year later, but not vice versa; associations were particularly strong for boys. PMID:28876524

  5. Technology-Based Communication and the Development of Interpersonal Competencies Within Adolescent Romantic Relationships: A Preliminary Investigation.

    Science.gov (United States)

    Nesi, Jacqueline; Widman, Laura; Choukas-Bradley, Sophia; Prinstein, Mitchell J

    2017-06-01

    This study investigated longitudinal associations between adolescents' technology-based communication and the development of interpersonal competencies within romantic relationships. A school-based sample of 487 adolescents (58% girls; M age  = 14.1) participated at two time points, one year apart. Participants reported (1) proportions of daily communication with romantic partners via traditional modes (in person, on the phone) versus technological modes (text messaging, social networking sites) and (2) competence in the romantic relationship skill domains of negative assertion and conflict management. Results of cross-lagged panel models indicated that adolescents who engaged in greater proportions of technology-based communication with romantic partners reported lower levels of interpersonal competencies one year later, but not vice versa; associations were particularly strong for boys. © 2016 The Authors. Journal of Research on Adolescence © 2016 Society for Research on Adolescence.

  6. Targeting binge eating through components of dialectical behavior therapy: preliminary outcomes for individually supported diary card self-monitoring versus group-based DBT.

    Science.gov (United States)

    Klein, Angela S; Skinner, Jeremy B; Hawley, Kristin M

    2013-12-01

    The current study examined two condensed adaptations of dialectical behavior therapy (DBT) for binge eating. Women with full- or sub-threshold variants of either binge eating disorder or bulimia nervosa were randomly assigned to individually supported self-monitoring using adapted DBT diary cards (DC) or group-based DBT, each 15 sessions over 16 weeks. DC sessions focused on problem-solving diary card completion issues, praising diary card completion, and supporting nonjudgmental awareness of eating-related habits and urges, but not formally teaching DBT skills. Group-based DBT included eating mindfulness, progressing through graded exposure; mindfulness, emotion regulation, and distress tolerance skills; and coaching calls between sessions. Both treatments evidenced large and significant improvements in binge eating, bulimic symptoms, and interoceptive awareness. For group-based DBT, ineffectiveness, drive for thinness, body dissatisfaction, and perfectionism also decreased significantly, with medium to large effect sizes. For DC, results were not significant but large in effect size for body dissatisfaction and medium in effect size for ineffectiveness and drive for thinness. Retention for both treatments was higher than recent trends for eating disorder treatment in fee-for-service practice and for similar clinic settings, but favored DC, with the greater attrition of group-based DBT primarily attributed to its more intensive and time-consuming nature, and dropout overall associated with less pretreatment impairment and greater interoceptive awareness. This preliminary investigation suggests that with both abbreviated DBT-based treatments, substantial improvement in core binge eating symptoms is possible, enhancing potential avenues for implementation beyond more time-intensive DBT.

  7. [Facial injections of hyaluronic acid-based fillers for malformations. Preliminary study regarding scar tissue improvement and cosmetic betterment].

    Science.gov (United States)

    Franchi, G; Neiva-Vaz, C; Picard, A; Vazquez, M-P

    2018-02-02

    Cross-linked hyaluronic acid-based fillers have gained rapid acceptance for treating facial wrinkles, deep tissue folds and sunken areas due to aging. This study evaluates, in addition to space-filling properties, their effects on softness and elasticity as a secondary effect, following injection of 3 commercially available cross-linked hyaluronic acid-based fillers (15mg/mL, 17,5mg/mL and 20mg/mL) in patients presenting with congenital or acquired facial malformations. We started injecting gels of cross-linked hyaluronic acid-based fillers in those cases in 2013; we performed 46 sessions of injections in 32 patients, aged from 13-32. Clinical assessment was performed by the patient himself and by a plastic surgeon, 15 days after injections and 6-18 months later. Cross-linked hyaluronic acid-based fillers offered very subtle cosmetic results and supplemented surgery with a very high level of satisfaction of the patients. When injected in fibrosis, the first session enhanced softness and elasticity; the second session enhanced the volume. Cross-linked hyaluronic acid-based fillers fill sunken areas and better softness and elasticity of scar tissues. In addition to their well-understood space-filling function, as a secondary effect, the authors demonstrate that cross-linked hyaluronic acid-based fillers improve softness and elasticity of scarring tissues. Many experimental studies support our observations, showing that cross-linked hyaluronic acid stimulates the production of several extra-cellular matrix components, including dermal collagen and elastin. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

  8. Game-Based Virtual Reality Canoe Paddling Training to Improve Postural Balance and Upper Extremity Function: A Preliminary Randomized Controlled Study of 30 Patients with Subacute Stroke.

    Science.gov (United States)

    Lee, Myung Mo; Lee, Kyeong Jin; Song, Chang Ho

    2018-04-27

    BACKGROUND Virtual reality (VR) training with motion-controlled console games can be incorporated into stroke rehabilitation programs. The use of a variety of gaming software can provide the patient with an opportunity to perform activities that are exciting, entertaining, and that may not be feasible in clinical environments. The aim of this preliminary randomized controlled study was to investigate the effects of game-based VR canoe paddling training, when combined with conventional physical rehabilitation programs, on postural balance and upper extremity function in 30 patients with subacute stroke. MATERIAL AND METHODS Thirty patients, who were within six months following the diagnosis of stroke, were randomly allocated to either the experimental group (n=15) or the control group (n=15). All participants participated in a conventional rehabilitation program. Also, the experimental group (n=15) performed the VR canoe paddling training for 30 minutes each day, three times per week, for five weeks. After five weeks, outcomes of changes in postural balance and upper extremity function were evaluated and compared between the two groups. RESULTS At five weeks, postural balance and upper extremity function showed significant improvements in both patients groups when compared with the baseline measurements (pGame-based VR canoe paddling training is an effective rehabilitation therapy that enhances postural balance and upper extremity function in patients with subacute stroke when combined with conventional physical rehabilitation programs.

  9. [Establishment of an Animal Based Therapy at a University Hospital for Psychiatry: Results of a Preliminary Study and Future Prospects].

    Science.gov (United States)

    Hartfiel, Cajetan; Bodatsch, Mitja; Klosterkötter, Joachim; Kuhn, Jens

    2017-01-01

    Objective: Dogs have been integrated in human society over centuries. This process has selected unique social and communicative skills. Dogs are thus able to represent social substitutes for human counterparts in cases of social withdrawal. Furthermore, dogs act as "social catalysts" in promoting interhuman encounters. Thus, the integration of dogs in psychotherapeutic concepts addressing social and interpersonal deficits may be of special interest. Methods: The present investigation reports the results of a pilot study to establish animal-assisted therapy (dogs) at a psychiatric department. The animal-assisted intervention straddled the following areas: (1) contact making, communication and orientation to needs, (2) recreation and play, (3) outward orientation, (4) release and farewell. The sample comprised 22 subjects. Results: The results demonstrated in particular that the animal-assisted intervention significantly promoted unspecific aspects of positive affectivity and wellbeing. Evaluation of the overall acceptance of the dog on the psychiatric ward revealed very positive feedback. Conclusions: We conclude that animal-assisted therapies represent a significant enchrichment of the therapeutic context, that may be used to enhance the patients' openness and adherence to conventional therapies. © Georg Thieme Verlag KG Stuttgart · New York.

  10. A Web-based searchable system to confirm magnetic resonance compatibility of implantable medical devices in Japan: a preliminary study.

    Science.gov (United States)

    Fujiwara, Yasuhiro; Fujioka, Hitoshi; Watanabe, Tomoko; Sekiguchi, Maiko; Murakami, Ryuji

    2017-09-01

    Confirmation of the magnetic resonance (MR) compatibility of implanted medical devices (IMDs) is mandatory before conducting magnetic resonance imaging (MRI) examinations. In Japan, few such confirmation methods are in use, and they are time-consuming. This study aimed to develop a Web-based searchable MR safety information system to confirm IMD compatibility and to evaluate the usefulness of the system. First, MR safety information for intravascular stents and stent grafts sold in Japan was gathered by interviewing 20 manufacturers. These IMDs were categorized based on the descriptions available on medical package inserts as: "MR Safe," "MR Conditional," "MR Unsafe," "Unknown," and "No Medical Package Insert Available". An MR safety information database for implants was created based on previously proposed item lists. Finally, a Web-based searchable system was developed using this database. A questionnaire was given to health-care personnel in Japan to evaluate the usefulness of this system. Seventy-nine datasets were collected using information provided by 12 manufacturers and by investigating the medical packaging of the IMDs. Although the datasets must be updated by collecting data from other manufacturers, this system facilitates the easy and rapid acquisition of MR safety information for IMDs, thereby improving the safety of MRI examinations.

  11. Preliminary studies of pest constraints to cotton seedlings in a direct seeding mulch-based system in Cameroon

    NARCIS (Netherlands)

    Brevault, T.; Guibert, H.; Naudin, K.

    2009-01-01

    The present study evaluated the pest constraints of an innovative crop management system in Cameroon involving conservation tillage and direct seeding mulch-based strategies. We hypothesized that the presence of mulch (i) would support a higher density of phytophagous arthropods particularly

  12. Development and preliminary testing of a web-based, self-help application for disaster-affected families.

    Science.gov (United States)

    Yuen, Erica K; Gros, Kirstin; Welsh, Kyleen E; McCauley, Jenna; Resnick, Heidi S; Danielson, Carla K; Price, Matthew; Ruggiero, Kenneth J

    2016-09-01

    Technology-based self-help interventions have the potential to increase access to evidence-based mental healthcare, especially for families affected by natural disasters. However, development of these interventions is a complex process and poses unique challenges. Usability testing, which assesses the ability of individuals to use an application successfully, can have a significant impact on the quality of a self-help intervention. This article describes (a) the development of a novel web-based multi-module self-help intervention for disaster-affected adolescents and their parents and (b) a mixed-methods formal usability study to evaluate user response. A total of 24 adolescents were observed, videotaped, and interviewed as they used the depressed mood component of the self-help intervention. Quantitative results indicated an above-average user experience, and qualitative analysis identified 120 unique usability issues. We discuss the challenges of developing self-help applications, including design considerations and the value of usability testing in technology-based interventions, as well as our plan for widespread dissemination. © The Author(s) 2015.

  13. Development and Preliminary Impacts of the Implementation of an Authentic Research-Based Experiment in General Chemistry

    Science.gov (United States)

    Tomasik, Janice Hall; Cottone, Katelyn E.; Heethuis, Mitchell T.; Mueller, Anja

    2013-01-01

    Incorporating research-based lab activities into general chemistry at a large university can be challenging, considering the high enrollments and costs typically associated with the courses. Performing sweeping curricular overhauls of the general chemistry laboratory can be difficult, and in some cases discouraged, as many would rather maintain…

  14. Potential of bioethanol as a chemical building block for biorefineries: Preliminary sustainability assessment of 12 bioethanol-based products

    NARCIS (Netherlands)

    Posada Duque, J.A.; Patel, A.D.; Roes, A.L.; Blok, K.; Faaij, A.P.C.; Patel, M.K.

    2013-01-01

    The aim of this study is to present and apply aquick screening method and to identify the most promising bioethanol derivatives using an early- stage sustainability assessment method that compares abioetha- nol-base d conversion route to its respective petrochemical counterpart. The method

  15. Potential of bioethanol as a chemical building block for biorefineries: Preliminary sustainability assessment of 12 bioethanol-based products

    NARCIS (Netherlands)

    Posada Duque, J.A.; Patel, A.D.; Roes, A.L.; Blok, K.; Faaij, A.P.C.; Patel, M.K.

    2013-01-01

    The aim of this study is to present and apply a quick screening method and to identify the most promising bioethanol derivatives using an early-stage sustainability assessment method that compares a bioethanol-based conversion route to its respective petrochemical counterpart. The method combines,

  16. Exploring Preschoolers' Engagement and Perceived Physical Competence in an Autonomy-Based Object Control Skill Intervention: A Preliminary Study

    Science.gov (United States)

    Logan, Samuel; Robinson, Leah; Webster, E. Kipling; Barber, Laura

    2013-01-01

    The purpose of this study was to describe children's engagement during two (high and low) autonomy-based climates. Twenty-five preschool children participated in a nine-week object control skill intervention. Children completed the object control subscale of the Test of Gross Motor Development 2nd Edition and the perceived physical competence…

  17. Evidence-based emergency medicine. Creating a system to facilitate translation of evidence into standardized clinical practice: a preliminary report.

    Science.gov (United States)

    Wright, Stewart W; Trott, Alexander; Lindsell, Christopher J; Smith, Carol; Gibler, W Brian

    2008-01-01

    The Institute of Medicine, through its landmark report concerning errors in medicine, suggests that standardization of practice through systematic development and implementation of evidence-based clinical pathways is an effective way of reducing errors in emergency systems. The specialty of emergency medicine is well positioned to develop a complete system of innovative quality improvement, incorporating best practice guidelines with performance measures and practitioner feedback mechanisms to reduce errors and therefore improve quality of care. This article reviews the construction, ongoing development, and initial impact of such a system at a large, urban, university teaching hospital and at 2 affiliated community hospitals. The Committee for Procedural Quality and Evidence-Based Practice was formed within the Department of Emergency Medicine to establish evidence-based guidelines for nursing and provider care. The committee measures the effect of such guidelines, along with other quality measures, through pre- and postguideline patient care medical record audits. These measures are fed back to the providers in a provider-specific, peer-matched "scorecard." The Committee for Procedural Quality and Evidence-Based Practice affects practice and performance within our department. Multiple physician and nursing guidelines have been developed and put into use. Using asthma as an example, time to first nebulizer treatment and time to disposition from the emergency department decreased. Initial therapeutic agent changed and documentation improved. A comprehensive, guideline-driven, evidence-based approach to clinical practice is feasible within the structure of a department of emergency medicine. High-level departmental support with dedicated personnel is necessary for the success of such a system. Internet site development (available at http://www.CPQE.com) for product storage has proven valuable. Patient care has been improved in several ways; however, consistent and

  18. Preliminary thermodynamic study of regenerative Otto based cycles with zero NOx emissions operating with adiabatic and polytropic expansion

    International Nuclear Information System (INIS)

    Garcia, Ramon Ferreiro; Carril, Jose Carbia; Romero Gomez, Javier; Romero Gomez, Manuel

    2016-01-01

    Highlights: • Efficient polytropic expansion based Otto cycle. • Thermal efficiency is due to the inherent regeneration. • Low temperature combustion with zero NOx emissions. - Abstract: The aim of the paper is to demonstrate that a regenerative Otto cycle with adiabatic or polytropic expansion can achieve improved performance over traditional Otto engines, even exceeding the Carnot factor. Thus, the work deals with a novel regenerative Otto based internal combustion engine which differs from the conventional Otto thermal cycles in that the process of heat conversion into mechanical work is performed obeying a polytropic path function instead of the conventional adiabatic expansion without regeneration. Design characteristics concern the fact that combustion at constant volume is carried out undergoing large air excess so that the top combustion temperature is significantly lower than in conventional Otto cycles and consequently NOx emissions are neglected. Furthermore, during the polytropic expansion based path function, heat is absorbed by being submitted to a controlled heat flow rate, to achieve the desired polytropic expansion. The analysis of the regenerative Otto based on polytropic expansion is presented and results are compared with a regenerative Otto based on the adiabatic expansion and CF. The results show that a relevant advantage of the proposed regenerative Otto with polytropic expansion over the regenerative Otto cycle with adiabatic expansion involves performance enhancement within a wide range of combustion pressures, temperatures and regeneration capacities. Thus, thermal efficiency and specific work as function of the top combustion pressure ranges are of 71.95–58.43% and 143.5–173.6 kJ/kg respectively, when combustion pressures vary between 105 kPa and 200 kPa and CF is 60.8% (lower than the thermal efficiency). The successful results involving a compact engine structure, technically and economically viable, promises a new generation

  19. Does perturbation-based balance training prevent falls? Systematic review and meta-analysis of preliminary randomized controlled trials.

    Science.gov (United States)

    Mansfield, Avril; Wong, Jennifer S; Bryce, Jessica; Knorr, Svetlana; Patterson, Kara K

    2015-05-01

    Older adults and individuals with neurological conditions are at an increased risk for falls. Although physical exercise can prevent falls, certain types of exercise may be more effective. Perturbation-based balance training is a novel intervention involving repeated postural perturbations aiming to improve control of rapid balance reactions. The purpose of this study was to estimate the effect of perturbation-based balance training on falls in daily life. MEDLINE (1946-July 2014), EMBASE (1974-July 2014), PEDro (all dates), CENTRAL (1991-July 2014), and Google Scholar (all dates) were the data sources used in this study. Randomized controlled trials written in English were included if they focused on perturbation-based balance training among older adults or individuals with neurological conditions and collected falls data posttraining. Two investigators extracted data independently. Study authors were contacted to obtain missing information. A PEDro score was obtained for each study. Primary outcomes were proportion of participants who reported one or more falls (ie, number of "fallers") and the total number of falls. The risk ratio (proportion of fallers) and rate ratio (number of falls) were entered into the analysis. Eight studies involving 404 participants were included. Participants who completed perturbation-based balance training were less likely to report a fall (overall risk ratio=0.71; 95% confidence interval=0.52, 0.96; P=.02) and reported fewer falls than those in the control groups (overall rate ratio=0.54; 95% confidence interval=0.34, 0.85; P=.007). Study authors do not always identify that they have included perturbation training in their intervention; therefore, it is possible that some appropriate studies were not included. Study designs were heterogeneous, preventing subanalyses. Perturbation-based balance training appears to reduce fall risk among older adults and individuals with Parkinson disease. © 2015 American Physical Therapy Association.

  20. Anomalous Structure of Oceanic Lithosphere in the North Atlantic and Arctic Oceans: A Preliminary Analysis Based on Bathymetry, Gravity and Crustal Structure

    Science.gov (United States)

    Barantsrva, O.

    2014-12-01

    We present a preliminary analysis of the crustal and upper mantle structure for off-shore regions in the North Atlantic and Arctic oceans. These regions have anomalous oceanic lithosphere: the upper mantle of the North Atlantic ocean is affected by the Iceland plume, while the Arctic ocean has some of the slowest spreading rates. Our specific goal is to constrain the density structure of the upper mantle in order to understand the links between the deep lithosphere dynamics, ocean spreading, ocean floor bathymetry, heat flow and structure of the oceanic lithosphere in the regions where classical models of evolution of the oceanic lithosphere may not be valid. The major focus is on the oceanic lithosphere, but the Arctic shelves with a sufficient data coverage are also included into the analysis. Out major interest is the density structure of the upper mantle, and the analysis is based on the interpretation of GOCE satellite gravity data. To separate gravity anomalies caused by subcrustal anomalous masses, the gravitational effect of water, crust and the deep mantle is removed from the observed gravity field. For bathymetry we use the global NOAA database ETOPO1. The crustal correction to gravity is based on two crustal models: (1) global model CRUST1.0 (Laske, 2013) and, for a comparison, (2) a regional seismic model EUNAseis (Artemieva and Thybo, 2013). The crustal density structure required for the crustal correction is constrained from Vp data. Previous studies have shown that a large range of density values corresponds to any Vp value. To overcome this problem and to reduce uncertainty associated with the velocity-density conversion, we account for regional tectonic variations in the Northern Atlantics as constrained by numerous published seismic profiles and potential-field models across the Norwegian off-shore crust (e.g. Breivik et al., 2005, 2007), and apply different Vp-density conversions for different parts of the region. We present preliminary results

  1. Impaired Cognitive Control of Emotional Conflict in Trait Anxiety: A Preliminary Study Based on Clinical and Non-Clinical Individuals

    Directory of Open Access Journals (Sweden)

    Yongju Yu

    2018-04-01

    Full Text Available BackgroundIt has been observed that trait anxiety easily leads to conflict maladaptation under conflict circumstances. However, it remains unclear whether the precise neural mechanisms underlying the effects of high trait anxiety (HTA on cognitive control are consistent in high trait anxious individuals, with and without anxiety disorders.MethodsThe present study recruited 29 healthy volunteers with low trait anxiety (LTA, 37 healthy volunteers with HTA, and 23 patients with generalized anxiety disorder (GAD. All participants completed demographic information and self-report measures of trait anxiety and depression. Then, they performed the emotional flanker task with event-related potentials (ERPs recorded.ResultsBehavioral data manifested that, relative to LTA individuals, GAD patients displayed prolonged response times and increased error rates, while HTA individuals showed intact response times and accuracies. Event-related potential (ERP data revealed that HTA individuals exhibited a trend toward more negative N2 amplitudes for conflict detection. By contrast, both HTA and GAD individuals displayed decreased P3 amplitudes for conflict resolution. ERP results indicated that both HTA and GAD individuals exhibited conflict maladaptation on the N2 amplitude. Correlation analyses also showed that the increased anxiety symptoms were associated with longer reaction times, more error rates, lower P3 amplitudes, and more perturbations in conflict adaptation on reaction times and N2 amplitudes.ConclusionOur results demonstrated a severely impaired cognitive control in GAD patients while a moderately impaired cognitive control in HTA individuals. Trait anxiety can indeed serve as a predominant factor at the onset and in the maintenance of GAD. Therefore, the trait anxiety reducing strategies may provide significant therapeutic gains.

  2. Preliminary Study of Hemodynamic Distribution in Patient-Specific Stenotic Carotid Bifurcation by Image-Based Computational Fluid Dynamics

    International Nuclear Information System (INIS)

    Xue, Y.J.; Gao, P.Y.; Duan, Q.; Lin, Y.; Dai, C.B.

    2008-01-01

    Background: Regions prone to atherosclerosis, such as bends and bifurcations, tend to exhibit a certain degree of non-planarity or curvature, and these geometric features are known to strongly influence local flow patterns. Recently, computational fluid dynamics (CFD) has been used as a means of enhancing understanding of the mechanisms involved in atherosclerotic plaque formation and development. Purpose: To analyze flow patterns and hemodynamic distribution in stenotic carotid bifurcation in vivo by combining CFD with magnetic resonance angiography (MRA). Material and Methods: Twenty-one patients with carotid atherosclerosis proved by digital subtraction angiography (DSA) and/or Doppler ultrasound underwent contrast-enhanced MR angiography of the carotid bifurcation by a 3.0T MR scanner. Hemodynamic variables and flow patterns of the carotid bifurcation were calculated and visualized by combining vascular imaging postprocessing with CFD. Results: In mild stenotic cases, there was much more streamlined flow in the bulbs, with reduced or disappeared areas of weakly turbulent flow. Also, the corresponding areas of low wall shear stress (WSS) were reduced or even disappeared. As the extent of stenosis increased, stronger blood jets formed at the portion of narrowing, and more prominent eddy flows and slow back flows were noted in the lee of the stenosis. Regions of elevated WSS were predicted at the portion of stenosis and in the path of the downstream jet. Areas of low WSS were predicted on the leeward side of the stenosis, corresponding with the location of slowly turbulent flows. Conclusion: CFD combined with MRA can simulate flow patterns and calculate hemodynamic variables in stenotic carotid bifurcations as well as normal ones. It provides a new method to investigate the relationship of vascular geometry and flow condition with atherosclerotic pathological changes

  3. [Preliminary study on general safe medication regularity of Chinese patent orthopedic medicines based on adverse reaction/event literature analysis].

    Science.gov (United States)

    Wang, Yu-guang; Shi, Xin-yuan; Jin, Rui; Li, Hong-yan; Kong, Xiang-wen; Qiao, Yan-jiang

    2015-03-01

    Chinese patent orthopedic medicines feature complex components, mainly including desperate and toxic herbal pieces, narrow safety window, more clinical contraindications and frequent adverse drug reaction/events (ADR/ADE). To study the general safe medication regularity of Chinese patent orthopedic medicines, define key points in the medication education and ensure rational clinical medication, the authors took 80 types of commonly used Chinese patent orthopedic medicines as the study objects, collect 237 cases from 164 ADR/ADE documents through a system retrieval strategy, make a multidimensional literature analysis to determine the common risk factors for safe and rational medication of Chinese patent orthopedic medicines and establish an ADR/ADE prevention regularity. First, in the aspect of clinical symptoms, skin allergy is the most common ADR/ADE and closely related to the toxic ingredients, particularly accumulated liver or kidney damage caused by some drugs. Second, there are three time nodes in the ADR/ADE occurrence; The ADR/ADE occurred in 30 minutes is closely related to the idiosyncrasy; the ADR/ADE occurred between several months and half a year is related to the drug-induced liver and kidney damages; The most common ADR/ADE was observed within 7 days and predictable according to the pharmacological actions; Third, toxicity is an important factor in the occurrence of ADR/ADE of Chinese patent orthopedic medicines. Fourth, emphasis shall be given to the special medication factors, such as the combination with western medicines and Chinese herbal decoctions, overdose and long-course medication and self-medical therapy. In conclusion, the general ADR/ADE prevention regularity for Chinese patent orthopedic medicines was summarized to provide supports for clinicians in safe and rational medication and give the guidance for pharmacist in medication education.

  4. Structure optimization and preliminary bioactivity evaluation of N-hydroxybenzamide-based HDAC inhibitors with Y-shaped cap.

    Science.gov (United States)

    Yu, Chenggong; He, Feng; Qu, Ying; Zhang, Qiuqiong; Lv, Jiahui; Zhang, Xiangna; Xu, Ana; Miao, Pannan; Wu, Jingde

    2018-05-01

    Histone deacetylase inhibitors (HDACIs) are effective small molecules in the treatment of human cancers. In our continuing efforts to develop novel N-hydroxyterephthalamide-based HDACIs, herein we report the design and development of a new class of N-hydroxybenzamide-based HDACIs. In this new class of analogs, we inserted an ethylene moiety in the linker and used indole as a part of the Y-shaped cap group. Biological characterization identified compounds 4o, 4p, 4q and 4t to show improved HDAC inhibition, while no isoform selectivity for HDACs was observed. These compounds also exhibited improved anti-proliferative activity against multiple cancer cell lines when compared to their parent compound and positive control SAHA. Copyright © 2018 Elsevier Ltd. All rights reserved.

  5. A mindfulness-based intervention to control weight after bariatric surgery: Preliminary results from a randomized controlled pilot trial.

    Science.gov (United States)

    Chacko, Sara A; Yeh, Gloria Y; Davis, Roger B; Wee, Christina C

    2016-10-01

    This study aimed to develop and test a novel mindfulness-based intervention (MBI) designed to control weight after bariatric surgery. Randomized, controlled pilot trial. Beth Israel Deaconess Medical Center, Boston, MA, USA. Bariatric patients 1-5 years post-surgery (n=18) were randomized to receive a 10-week MBI or a standard intervention. Primary outcomes were feasibility and acceptability of the MBI. Secondary outcomes included changes in weight, eating behaviors, psychosocial outcomes, and metabolic and inflammatory biomarkers. Qualitative exit interviews were conducted post-intervention. Major themes were coded and extracted. Attendance was excellent (6 of 9 patients attended ≥7 of 10 classes). Patients reported high satisfaction and overall benefit of the MBI. The intervention was effective in reducing emotional eating at 6 months (-4.9±13.7 in mindfulness vs. 6.2±28.4 in standard, p for between-group difference=0.03) but not weight. We also observed a significant increase in HbA1C (0.34±0.38 vs. -0.06±0.31, p=0.03). Objective measures suggested trends of an increase in perceived stress and symptoms of depression, although patients reported reduced stress reactivity, improved eating behaviors, and a desire for continued mindfulness-based support in qualitative interviews. This novel mindfulness-based approach is highly acceptable to bariatric patients post-surgery and may be effective for reducing emotional eating, although it did not improve weight or glycemic control in the short term. Longer-term studies of mindfulness-based approaches may be warranted in this population. ClinicalTrials.gov identifier NCT02603601. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. [Preliminary construction of three-dimensional visual educational system for clinical dentistry based on world wide web webpage].

    Science.gov (United States)

    Hu, Jian; Xu, Xiang-yang; Song, En-min; Tan, Hong-bao; Wang, Yi-ning

    2009-09-01

    To establish a new visual educational system of virtual reality for clinical dentistry based on world wide web (WWW) webpage in order to provide more three-dimensional multimedia resources to dental students and an online three-dimensional consulting system for patients. Based on computer graphics and three-dimensional webpage technologies, the software of 3Dsmax and Webmax were adopted in the system development. In the Windows environment, the architecture of whole system was established step by step, including three-dimensional model construction, three-dimensional scene setup, transplanting three-dimensional scene into webpage, reediting the virtual scene, realization of interactions within the webpage, initial test, and necessary adjustment. Five cases of three-dimensional interactive webpage for clinical dentistry were completed. The three-dimensional interactive webpage could be accessible through web browser on personal computer, and users could interact with the webpage through rotating, panning and zooming the virtual scene. It is technically feasible to implement the visual educational system of virtual reality for clinical dentistry based on WWW webpage. Information related to clinical dentistry can be transmitted properly, visually and interactively through three-dimensional webpage.

  7. Feasibility, Acceptability, and Preliminary Effectiveness of a 4-week Mindfulness-Based Cognitive Therapy Protocol for Hospital Employees.

    Science.gov (United States)

    Luberto, Christina M; Wasson, Rachel S; Kraemer, Kristen M; Sears, Richard W; Hueber, Carly; Cotton, Sian

    2017-12-01

    Hospital employees may experience occupational stress and burnout, which negatively impact quality of life and job performance. Evidence-based interventions implemented within the hospital setting are needed to promote employees' well-being. We offered a 4-week Mindfulness-Based Cognitive Therapy group program for hospital employees, and used a mixed-methods practice-based research approach to explore feasibility, acceptability, and effects on stress and burnout. Participants were 65 hospital employees ( M age = 44.06; 85% white) who participated between September 2015 and January 2016. Participants completed validated measures of stress and burnout before and after the program, and answered open-ended satisfaction questions after the program. Groups consistently enrolled at least 10 participants, but attendance rates declined across sessions (76% at session 2 vs. 54% at session 4) due primarily to work-related scheduling conflicts. The program content was acceptable as evidenced by high perceived value ( M = 9.18 out of 10), homework compliance (51% practicing at least 3 times/week), and qualitative requests for program expansion. There were large, statistically significant decreases in stress (Δ M = 2.1, p strategies to enhance session attendance.

  8. Development and preliminary evaluation of a new anatomically based prosthetic alignment method for below-knee prosthesis.

    Science.gov (United States)

    Tafti, Nahid; Karimlou, Masoud; Mardani, Mohammad Ali; Jafarpisheh, Amir Salar; Aminian, Gholam Reza; Safari, Reza

    2018-04-20

    The objectives of current study were to a) assess similarities and relationships between anatomical landmark-based angles and distances of lower limbs in unilateral transtibial amputees and b) develop and evaluate a new anatomically based static prosthetic alignment method. First sub-study assessed the anthropometrical differences and relationships between the lower limbs in the photographs taken from amputees. Data were analysed via paired t-test and regression analysis. Results show no significant differences in frontal and transverse planes. In the sagittal plane, the anthropometric parameters of the amputated limb were significantly correlated to the corresponding variables of the sound limb. The results served as bases for the development of a new prosthetic alignment method. The method was evaluated on a single subject study. Prosthetic alignment carried out by an experienced prosthetist was compared with such alignment adjusted by an inexperienced prosthetist but with the use of the developed method. In sagittal and frontal planes, the socket angle was tuned with respect to the shin angle, and the position of the prosthetic foot was tuned in relation to the pelvic landmarks. Further study is needed to assess the proposed method on a larger sample of amputees and prosthetists.

  9. A Preliminary Investigation of Temperature Dependency of a Shape Memory Actuator with Time-Based Control in Aircraft Interiors

    Science.gov (United States)

    Otibar, Dennis; Weirich, Antonia; Kortenjann, Marcus; Kuhlenkötter, Bernd

    2017-06-01

    Shape memory alloys (SMA) possess an array of unique functional properties which are influenced by a complex interaction of different factors. Due to thermal sensitivity, slight changes in the environmental temperature may cause the properties to change significantly. This poses a huge challenge especially for the use of SMAs as actuators. The most common and elementary activation strategy of SMA actuators is based on the duration of activation and cooling with constant activation parameters. However, changing environmental influences cause the necessity to modify these parameters. This circumstance needs to be especially considered in the design process of actuator controls. This paper focuses on investigating the influence of environmental temperature changes on time-based activated SMA actuators. The results of the described experiments form the base for designing reactive control strategies for SMA actuators used in alternating environments. An example for application fields with changing environments and particularly changing temperatures are aircraft related implementations. This area also stands to benefit from the actuators’ advantages in ecological efficiency.

  10. Developing and Evaluating Communication Strategies to Support Informed Decisions and Practice Based on Evidence (DECIDE): protocol and preliminary results.

    Science.gov (United States)

    Treweek, Shaun; Oxman, Andrew D; Alderson, Philip; Bossuyt, Patrick M; Brandt, Linn; Brożek, Jan; Davoli, Marina; Flottorp, Signe; Harbour, Robin; Hill, Suzanne; Liberati, Alessandro; Liira, Helena; Schünemann, Holger J; Rosenbaum, Sarah; Thornton, Judith; Vandvik, Per Olav; Alonso-Coello, Pablo

    2013-01-09

    Healthcare decision makers face challenges when using guidelines, including understanding the quality of the evidence or the values and preferences upon which recommendations are made, which are often not clear. GRADE is a systematic approach towards assessing the quality of evidence and the strength of recommendations in healthcare. GRADE also gives advice on how to go from evidence to decisions. It has been developed to address the weaknesses of other grading systems and is now widely used internationally. The Developing and Evaluating Communication Strategies to Support Informed Decisions and Practice Based on Evidence (DECIDE) consortium (http://www.decide-collaboration.eu/), which includes members of the GRADE Working Group and other partners, will explore methods to ensure effective communication of evidence-based recommendations targeted at key stakeholders: healthcare professionals, policymakers, and managers, as well as patients and the general public. Surveys and interviews with guideline producers and other stakeholders will explore how presentation of the evidence could be improved to better meet their information needs. We will collect further stakeholder input from advisory groups, via consultations and user testing; this will be done across a wide range of healthcare systems in Europe, North America, and other countries. Targeted communication strategies will be developed, evaluated in randomized trials, refined, and assessed during the development of real guidelines. Results of the DECIDE project will improve the communication of evidence-based healthcare recommendations. Building on the work of the GRADE Working Group, DECIDE will develop and evaluate methods that address communication needs of guideline users. The project will produce strategies for communicating recommendations that have been rigorously evaluated in diverse settings, and it will support the transfer of research into practice in healthcare systems globally.

  11. Text messaging as an adjunct to a web-based intervention for college student alcohol use: A preliminary study.

    Science.gov (United States)

    Tahaney, Kelli D; Palfai, Tibor P

    2017-10-01

    Brief, web-based motivational interventions have shown promising results for reducing alcohol use and associated harm among college students. However, findings regarding which alcohol use outcomes are impacted are mixed and effects tend to be small to moderate, with effect sizes decreasing over longer-term follow-up periods. As a result, these interventions may benefit from adjunctive strategies to bolster students' engagement with intervention material and to extend interventions beyond initial contacts into student's daily lives. This study tested the efficacy of text messaging as an adjunct to a web-based intervention for heavy episodic drinking college students. One-hundred and thirteen undergraduate student risky drinkers recruited from an introductory psychology class were randomly assigned to one of three conditions-assessment only (AO), web intervention (WI), and web intervention plus text messaging (WI+TXT). Heavy drinking episodes (HDEs), weekend quantity per occasion, and alcohol-related consequences were assessed at baseline and one month follow-up. Univariate analysis of covariance (ANCOVA) was used to assess the influence of condition assignment on 1-month outcomes, controlling for baseline variables. Planned contrasts showed that those in the WI+TXT condition showed significantly less weekend drinking than those in the AO and WI conditions. Although those in the WI+TXT condition showed significantly fewer HDEs compared to AO, it was not significantly different than the WI only condition. No differences were observed on alcohol-related problems. These findings provide partial support for the view that text messaging may be a useful adjunct to web-based interventions for reducing alcohol consumption among student drinkers. Copyright © 2017. Published by Elsevier Ltd.

  12. Preliminary design and optimization of a G-band extended interaction oscillator based on a pseudospark-sourced electron beam

    Energy Technology Data Exchange (ETDEWEB)

    Yin, Y., E-mail: yong.yin@strath.ac.uk, E-mail: yinyong@uestc.edu.cn [School of Physical Electronics, University of Electronic Science and Technology of China, Chengdu 610054 (China); Department of Physics, Scottish Universities Physics Alliance, University of Strathclyde, Glasgow G4 0NG (United Kingdom); He, W.; Zhang, L.; Yin, H.; Cross, A. W. [Department of Physics, Scottish Universities Physics Alliance, University of Strathclyde, Glasgow G4 0NG (United Kingdom)

    2015-07-15

    The design and simulation of a G-band extended interaction oscillator (EIO) driven by a pseudospark-sourced electron beam is presented. The characteristic of the EIO and the pseudospark-based electron beam were studied to enhance the performance of the newly proposed device. The beam-wave interaction of the EIO can be optimized by choosing a suitable pseudospark discharging voltage and by widening the operating voltage region of the EIO circuit. Simulation results show that a peak power of over 240 W can be achieved at G-band using a pseudospark discharge voltage of 41 kV.

  13. Brain expansion in patients with type II diabetes following insulin therapy: a preliminary study with longitudinal voxel-based morphometry.

    Science.gov (United States)

    Chen, Zhiye; Li, Jinfeng; Sun, Jie; Ma, Lin

    2014-01-01

    We performed a longitudinal analysis based on magnetic resonance (MR) imaging to investigate the brain structural and perfusion changes caused by insulin therapy in patients with type II diabetes. High resolution three-dimensional T1-weighted fast spoiled gradient recalled echo images and flow-sensitive alternating inversion recovery (FAIR) images were obtained from 11 patients with type II diabetes before and 1 year after initiation of insulin therapy and 11 normal controls. Brain volume changes were investigated by a longitudinal voxel-based morphometry (VBM), and perfusion changes were evaluated by FAIR imaging between baseline and follow-up data. Significant regional gray matter (GM) expansion located in bilateral frontal, parietal, and left occipital lobes, and regional white matter (WM) expansion was shown in left precentral subcortical WM and right angular subcortical WM after insulin therapy (P Brain hyperperfusion was detected in bilateral frontal cortex, left occipital cortex, and right temporal cortex after insulin therapy (P brain expansion and hyperperfusion were demonstrated 1 year after initiation of insulin therapy, and insulin therapy could contribute to the brain volume gainment in the patients with type II diabetes. Copyright © 2013 by the American Society of Neuroimaging.

  14. Does the use of alcohol-based hand gel sanitizer reduce travellers' diarrhea and gastrointestinal upset?: A preliminary survey.

    Science.gov (United States)

    Henriey, Delphine; Delmont, Jean; Gautret, Philippe

    2014-01-01

    Use of alcohol-based hand sanitizer is recommended by the CDC to reduce the risk for travellers' diarrhoea, but its effectiveness has not been assessed. We investigated the potential protective effect of hand sanitizer use on the occurrence of diarrhoea and/or vomiting in 200 international travellers, who were returning home, at an international airport. We also conducted a knowledge, aptitude and practice survey about hand gel use among international travellers consulting for pre-travel advice at a specialized clinic. 200 returning travellers were included of which 32.5% declared having used alcohol-based hand sanitizer during travel. Travellers who used hand sanitizer reported diarrhoea and vomiting significantly less frequently than those who did not (17% vs. 30%, OR = 0.47; 95% CI [0.21-0.97], p = 0.04). A total of 257 travellers consulting for pre-travel advice were included. A majority of travellers knew that hand sanitizer may be used for hand hygiene and had already used hand sanitizer; 72% planned to bring hand sanitizer during their next travel. Use of hand sanitizer is highly acceptable by travellers and is associated with a reduction in the incidence of travellers' diarrhoea and/or vomiting. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. ANCLI's conclusions and recommendations made after the ANCLI colloquium 'Tritium, discrete, but present everywhere'

    International Nuclear Information System (INIS)

    Sene, M.

    2009-01-01

    The authors briefly state the conclusions of the colloquium about the presence of tritium in the environment, its sanitary impact, the re-examination of a management based on release, the need to reduce tritium production. The recommendations are also indicated: to continue researches on organically bound tritium, not to allow any release increase as long as effects are not better known. The role of the ANCLI is outlined

  16. Adaptive tele-therapies based on serious games for health for people with time-management and organisational problems: preliminary results.

    Science.gov (United States)

    Frutos-Pascual, Maite; Zapirain, Begoña García; Zorrilla, Amaia Méndez

    2014-01-07

    Attention Deficit with Hyperactivity Disorder (ADHD) is one of the most prevalent disorders within the child population today. Inattention problems can lead to greater difficulties in completing assignments, as well as problems with time management and prioritisation of tasks. This article presents an intelligent tele-therapy tool based on Serious Games for Health, aimed at the improvement of time management skills and the prioritisation of tasks. This tele-system is based on the use of decision trees within Django, a high-level Python Web framework. The technologies and techniques used were selected so as to boost user involvement and to enable the system to be easily customised. This article shows the preliminary results of the pilot-phase in an experiment performed to evaluate the use of adaptive tele-therapies within a group of typically developing children and adolescents aged between 12 and 19 years old without ADHD. To do so, we relied on the collection of parameters and the conduct of surveys for assessing time management skills, as well as measuring system usability and availability. The results of a time management survey highlighted that the users involved in the trial did not use any specific or effective time management techniques, scoring 1.98 and 2.30 out of 5 points in this area for ages under 15 and over 16 years old, respectively. The final calculations based on the usability questionnaire resulted in an average score of 78.75 out of 100. The creation of a customisable tool capable of working with different skills, in conjunction with the replication of the current study, may help to understand these users' needs, as well as boosting time management skills among teenagers with and without ADHD.

  17. Adaptive Tele-Therapies Based on Serious Games for Health for People with Time-Management and Organisational Problems: Preliminary Results

    Directory of Open Access Journals (Sweden)

    Maite Frutos-Pascual

    2014-01-01

    Full Text Available Attention Deficit with Hyperactivity Disorder (ADHD is one of the most prevalent disorders within the child population today. Inattention problems can lead to greater difficulties in completing assignments, as well as problems with time management and prioritisation of tasks. This article presents an intelligent tele-therapy tool based on Serious Games for Health, aimed at the improvement of time management skills and the prioritisation of tasks. This tele-system is based on the use of decision trees within Django, a high-level Python Web framework. The technologies and techniques used were selected so as to boost user involvement and to enable the system to be easily customised. This article shows the preliminary results of the pilot-phase in an experiment performed to evaluate the use of adaptive tele-therapies within a group of typically developing children and adolescents aged between 12 and 19 years old without ADHD. To do so, we relied on the collection of parameters and the conduct of surveys for assessing time management skills, as well as measuring system usability and availability. The results of a time management survey highlighted that the users involved in the trial did not use any specific or effective time management techniques, scoring 1.98 and 2.30 out of 5 points in this area for ages under 15 and over 16 years old, respectively. The final calculations based on the usability questionnaire resulted in an average score of 78.75 out of 100. The creation of a customisable tool capable of working with different skills, in conjunction with the replication of the current study, may help to understand these users’ needs, as well as boosting time management skills among teenagers with and without ADHD.

  18. A cross-validation trial of an Internet-based prevention program for alcohol and cannabis: Preliminary results from a cluster randomised controlled trial.

    Science.gov (United States)

    Champion, Katrina E; Newton, Nicola C; Stapinski, Lexine; Slade, Tim; Barrett, Emma L; Teesson, Maree

    2016-01-01

    Replication is an important step in evaluating evidence-based preventive interventions and is crucial for establishing the generalizability and wider impact of a program. Despite this, few replications have occurred in the prevention science field. This study aims to fill this gap by conducting a cross-validation trial of the Climate Schools: Alcohol and Cannabis course, an Internet-based prevention program, among a new cohort of Australian students. A cluster randomized controlled trial was conducted among 1103 students (Mage: 13.25 years) from 13 schools in Australia in 2012. Six schools received the Climate Schools course and 7 schools were randomized to a control group (health education as usual). All students completed a self-report survey at baseline and immediately post-intervention. Mixed-effects regressions were conducted for all outcome variables. Outcomes assessed included alcohol and cannabis use, knowledge and intentions to use these substances. Compared to the control group, immediately post-intervention the intervention group reported significantly greater alcohol (d = 0.67) and cannabis knowledge (d = 0.72), were less likely to have consumed any alcohol (even a sip or taste) in the past 6 months (odds ratio = 0.69) and were less likely to intend on using alcohol in the future (odds ratio = 0.62). However, there were no effects for binge drinking, cannabis use or intentions to use cannabis. These preliminary results provide some support for the Internet-based Climate Schools: Alcohol and Cannabis course as a feasible way of delivering alcohol and cannabis prevention. Intervention effects for alcohol and cannabis knowledge were consistent with results from the original trial; however, analyses of longer-term follow-up data are needed to provide a clearer indication of the efficacy of the intervention, particularly in relation to behavioral changes. © The Royal Australian and New Zealand College of Psychiatrists 2015.

  19. Adaptive Tele-Therapies Based on Serious Games for Health for People with Time-Management and Organisational Problems: Preliminary Results

    Science.gov (United States)

    Frutos-Pascual, Maite; García Zapirain, Begoña; Méndez Zorrilla, Amaia

    2014-01-01

    Attention Deficit with Hyperactivity Disorder (ADHD) is one of the most prevalent disorders within the child population today. Inattention problems can lead to greater difficulties in completing assignments, as well as problems with time management and prioritisation of tasks. This article presents an intelligent tele-therapy tool based on Serious Games for Health, aimed at the improvement of time management skills and the prioritisation of tasks. This tele-system is based on the use of decision trees within Django, a high-level Python Web framework. The technologies and techniques used were selected so as to boost user involvement and to enable the system to be easily customised. This article shows the preliminary results of the pilot-phase in an experiment performed to evaluate the use of adaptive tele-therapies within a group of typically developing children and adolescents aged between 12 and 19 years old without ADHD. To do so, we relied on the collection of parameters and the conduct of surveys for assessing time management skills, as well as measuring system usability and availability. The results of a time management survey highlighted that the users involved in the trial did not use any specific or effective time management techniques, scoring 1.98 and 2.30 out of 5 points in this area for ages under 15 and over 16 years old, respectively. The final calculations based on the usability questionnaire resulted in an average score of 78.75 out of 100. The creation of a customisable tool capable of working with different skills, in conjunction with the replication of the current study, may help to understand these users’ needs, as well as boosting time management skills among teenagers with and without ADHD. PMID:24402063

  20. Initial evaluation of prostate cancer with real-time elastography based on step-section pathologic analysis after radical prostatectomy. A preliminary study

    International Nuclear Information System (INIS)

    Sumura, Masahiro; Shigeno, Kazushi; Hyuga, Taiju; Yoneda, Tatsuaki; Shiina, Hiroaki; Igawa, Mikio

    2007-01-01

    The objective of this study was to determine whether real-time elastography can be used to detect prostate cancer as a relatively non-invasive modality based on the tissue strain value. Seventeen patients underwent real-time elastography in conjunction with digital rectal examination (DRE), conventional gray-scale transrectal ultrasonography (TRUS), color Doppler ultrasonography (CDUS), and magnetic resonance imaging (MRI) prior to radical prostatectomy. The elastogram was compared to findings of conventional modalities and pathological findings of prostatectomy specimens. To obtain the elastogram, compression of the prostate was performed along with a visual indicator on a video screen. Twenty of 27 pathologically confirmed tumors were detected with real-time elastography. The cancer detection rate with real-time elastography was superior to the rates of other modalities and nearly equal to both on the anterior side (75.0%) and the posterior side (73.7%) of the prostate. A higher tumor detection rate for real-time elastography was observed for tumors with a higher Gleason score and larger tumor volume. In our preliminary study, real-time elastography in conjunction with gray-scale TRUS is a non-invasive modality to detect prostate cancer. (author)

  1. Potential of bioethanol as a chemical building block for biorefineries: preliminary sustainability assessment of 12 bioethanol-based products.

    Science.gov (United States)

    Posada, John A; Patel, Akshay D; Roes, Alexander; Blok, Kornelis; Faaij, André P C; Patel, Martin K

    2013-05-01

    The aim of this study is to present and apply a quick screening method and to identify the most promising bioethanol derivatives using an early-stage sustainability assessment method that compares a bioethanol-based conversion route to its respective petrochemical counterpart. The method combines, by means of a multi-criteria approach, quantitative and qualitative proxy indicators describing economic, environmental, health and safety and operational aspects. Of twelve derivatives considered, five were categorized as favorable (diethyl ether, 1,3-butadiene, ethyl acetate, propylene and ethylene), two as promising (acetaldehyde and ethylene oxide) and five as unfavorable derivatives (acetic acid, n-butanol, isobutylene, hydrogen and acetone) for an integrated biorefinery concept. Copyright © 2012 Elsevier Ltd. All rights reserved.

  2. The reliability and preliminary validity of game-based fall risk assessment in community-dwelling older adults.

    Science.gov (United States)

    Yamada, Minoru; Aoyama, Tomoki; Nakamura, Masatoshi; Tanaka, Buichi; Nagai, Koutatsu; Tatematsu, Noriatsu; Uemura, Kazuki; Nakamura, Takashi; Tsuboyama, Tadao; Ichihashi, Noriaki

    2011-01-01

    The purpose of this study was to examine whether the Nintendo Wii Fit program could be used for fall risk assessment in healthy, community-dwelling older adults. Forty-five community-dwelling older women participated in this study. The "Basic Step" and "Ski Slalom" modules were selected from the Wii Fit game program. The following 5 physical performance tests were performed: the 10-m walk test under single- and dual-task conditions, the Timed Up and Go test under single- and dual-task conditions, and the Functional Reach test. Compared with the faller group, the nonfaller group showed a significant difference in the Basic Step (P game-based fall risk assessment using the Basic Step has a high generality and is useful in community-dwelling older adults. Copyright © 2011 Mosby, Inc. All rights reserved.

  3. Water quality-based real time control of integrated urban drainage: a preliminary study from Copenhagen, Denmark

    DEFF Research Database (Denmark)

    Vezzaro, Luca; Lund Christensen, Margit; Thirsing, Carsten

    2013-01-01

    Global Real Time Control (RTC) of urban drainage systems is increasingly seen as cost-effective solution for responding to increasing performance demands. This study investigated the potential for including water-quality based RTC into the global control strategy which is under implementation...... in the Lynetten catchment (Copenhagen, Denmark). Two different strategies were simulated, considering: (i) water quality at the wastewater treatment plant (WWTP) inlet and (ii) pollution discharge to the bathing areas. These strategies were included in the Dynamic Overflow Risk Assessment (DORA) RTC strategy......, which allows for prioritization of the discharge points in the systems according to their sensitivity. A conceptual hydrological model was used to assess the performance of the integrated control strategy over an entire year. The simulation results showed the benefits of the proposed approaches...

  4. Preliminary Results on the Surface of a New Fe-Based Metallic Material after “In Vivo” Maintaining

    Science.gov (United States)

    Săndulache, F.; Stanciu, S.; Cimpoeşu, N.; Stanciu, T.; Cimpoeșu, R.; Enache, A.; Baciu, R.

    2017-06-01

    Abstract A new Fe-based alloy was obtained using UltraCast melting equipment. The alloy, after mechanical processing, was implanted in five rabbit specimens (with respect for the “in-bone” procedure). After 30 days of implantation the samples were recovered and analyzed by weight and surface state meanings. Scanning electron microscopy technique was used to determine the new compounds morphology from the metallic surface and X-ray dispersive energy spectroscopy for chemical analyze results. A bond between the metallic material and biological material of the bone was observed through increasing of sample weight and by SEM images. After the first set of tests, as the samples were extracted and biologically cleaned, the samples were ultrasonically cleaned and re-analyzed in order to establish the stability of the chemical compounds.

  5. Preliminary determination of geothermal working area based on Thermal Infrared and Synthetic Aperture Radar (SAR) remote sensing

    Science.gov (United States)

    Agoes Nugroho, Indra; Kurniawahidayati, Beta; Syahputra Mulyana, Reza; Saepuloh, Asep

    2017-12-01

    Remote sensing is one of the methods for geothermal exploration. This method can be used to map the geological structures, manifestations, and predict the geothermal potential area. The results from remote sensing were used as guidance for the next step exploration. Analysis of target in remote sensing is an efficient method to delineate geothermal surface manifestation without direct contact to the object. The study took a place in District Merangin, Jambi Province, Indonesia. The area was selected due to existing of Merangin volcanic complex composed by Mounts Sumbing and Hulunilo with surface geothermal manifestations presented by hot springs and hot pools. The location of surface manifestations could be related with local and regional structures of Great Sumatra Fault. The methods used in this study were included identification of volcanic products, lineament extraction, and lineament density quantification. The objective of this study is to delineate the potential zones for sitting the geothermal working site based on Thermal Infrared and Synthetic Aperture Radar (SAR) sensors. The lineament-related to geological structures, was aimed for high lineament density, is using ALOS - PALSAR (Advanced Land Observing Satellite - The Phased Array type L-band Synthetic Aperture Radar) level 1.1. The Normalized Difference Vegetation Index (NDVI) analysis was used to predict the vegetation condition using Landsat 8 OLI-TIRS (The Operational Land Imager - Thermal Infrared Sensor). The brightness temperature was extracted from TIR band to estimate the surface temperature. Geothermal working area identified based on index overlay method from extracted parameter of remote sensing data was located at the western part of study area (Graho Nyabu area). This location was identified because of the existence of high surface temperature about 30°C, high lineament density about 4 - 4.5 km/km2 and low NDVI values less than 0.3.

  6. Validation of model-based brain shift correction in neurosurgery via intraoperative magnetic resonance imaging: preliminary results

    Science.gov (United States)

    Luo, Ma; Frisken, Sarah F.; Weis, Jared A.; Clements, Logan W.; Unadkat, Prashin; Thompson, Reid C.; Golby, Alexandra J.; Miga, Michael I.

    2017-03-01

    The quality of brain tumor resection surgery is dependent on the spatial agreement between preoperative image and intraoperative anatomy. However, brain shift compromises the aforementioned alignment. Currently, the clinical standard to monitor brain shift is intraoperative magnetic resonance (iMR). While iMR provides better understanding of brain shift, its cost and encumbrance is a consideration for medical centers. Hence, we are developing a model-based method that can be a complementary technology to address brain shift in standard resections, with resource-intensive cases as referrals for iMR facilities. Our strategy constructs a deformation `atlas' containing potential deformation solutions derived from a biomechanical model that account for variables such as cerebrospinal fluid drainage and mannitol effects. Volumetric deformation is estimated with an inverse approach that determines the optimal combinatory `atlas' solution fit to best match measured surface deformation. Accordingly, preoperative image is updated based on the computed deformation field. This study is the latest development to validate our methodology with iMR. Briefly, preoperative and intraoperative MR images of 2 patients were acquired. Homologous surface points were selected on preoperative and intraoperative scans as measurement of surface deformation and used to drive the inverse problem. To assess the model accuracy, subsurface shift of targets between preoperative and intraoperative states was measured and compared to model prediction. Considering subsurface shift above 3 mm, the proposed strategy provides an average shift correction of 59% across 2 cases. While further improvements in both the model and ability to validate with iMR are desired, the results reported are encouraging.

  7. Some conclusions about the concrete strength of the bored piles of Angra 2 nuclear power plant

    International Nuclear Information System (INIS)

    Thomaz, E.C.S.; Joia, L.A.

    1984-01-01

    The concrete of the bored piles of Angra 2 was submitted to a deep control, so more than five thousand core samples were analyzed to verify the quality of the concrete. Based on these samples and using statistics regression theory some conclusions could be done. It was analyzed the dependence of the concrete strength upon the depth of the pile. Also based on these samples some probability distribution functions that could simulate the concrete strength were studied applying the Kolmogorov - Smirnov fitness test. Finally, a method for evaluating a confidence interval of one of the probability function (Weibull distribution) was developed adopting the Monte Carlo simulation technique. (Author) [pt

  8. Preliminary experience with 4K ultra-high definition endoscope: analysis of pros and cons in skull base surgery.

    Science.gov (United States)

    Rigante, M; La Rocca, G; Lauretti, L; D'Alessandris, G Q; Mangiola, A; Anile, C; Olivi, A; Paludetti, G

    2017-06-01

    During the last two decades endoscopic skull base surgery observed a continuous technical and technological development 3D endoscopy and ultra High Definition (HD) endoscopy have provided great advances in terms of visualisation and spatial resolution. Ultra-high definition (UHD) 4K systems, recently introduced in the clinical practice, will shape next steps forward especially in skull base surgery field. Patients were operated on through transnasal transsphenoidal endoscopic approaches performed using Olympus NBI 4K UHD endoscope with a 4 mm 0° Ultra Telescope, 300 W xenon lamp (CLV-S400) predisposed for narrow band imaging (NBI) technology connected through a camera head to a high-quality control unit (OTV-S400 - VISERA 4K UHD) (Olympus Corporation, Tokyo, Japan). Two screens are used, one 31" Monitor - (LMD-X310S) and one main ultra-HD 55" screen optimised for UHD image reproduction (LMD-X550S). In selected cases, we used a navigation system (Stealthstation S7, Medtronic, Minneapolis, MN, US). We evaluated 22 pituitary adenomas (86.3% macroadenomas; 13.7% microadenomas). 50% were not functional (NF), 22.8% GH, 18.2% ACTH, 9% PRL-secreting. Three of 22 were recurrences. In 91% of cases we achieved total removal, while in 9% near total resection. A mean follow-up of 187 days and average length of hospitalisation was 3.09 ± 0.61 days. Surgical duration was 128.18± 30.74 minutes. We experienced only 1 case of intraoperative low flow fistula with no further complications. None of the cases required any post- or intraoperative blood transfusion. The visualisation and high resolution of the operative field provided a very detailed view of all anatomical structures and pathologies allowing an improvement in safety and efficacy of the surgical procedure. The operative time was similar to the standard 2D HD and 3D procedures and the physical strain was also comparable to others in terms of ergonomics and weight. © Copyright by Società Italiana di Otorinolaringologia

  9. Effects of earthquakes on the deep repository for spent fuel in Sweden based on case studies and preliminary model results

    International Nuclear Information System (INIS)

    Baeckblom, Goeran; Munier, Raymond

    2002-06-01

    The Baltic Shield is one of the most stable areas in the world. Earthquakes have only on a few occasions exceeded magnitude 4 in Sweden in modern times. The safety case for a deep repository for spent fuel however includes an earthquake scenario due to the following reason: Earthquakes with much greater magnitudes occurred in northern Sweden during the most recent deglaciation period some 9,000 - 10,000 years ago when re-activated faults ruptured the surface. One of the most prominent evidences is the Paervie fault in Lapland, Sweden. The displacements exceeded 10 m in places and occurred over distances of around 150 km. The deep repository is designed to keep radiation well below the natural, ambient radiation for any time in the future. The safety function is achieved by a combination of engineered and natural barriers. One important safety issue is that future displacements in the rock should be less than 0.1 m at the precise location where the engineered canisters containing the waste are emplaced in the rock. Larger displacements could damage the canister that is designed to be tight for several 100,000 of years. SKB now re-visits the issues of seismic effects on underground facilities to supplement and update previous work. The project Effects of Earthquakes on Underground Facilities aims to re-compile field evidences of seismic damage on underground facilities, to shed additional light on the matter of friction loss in bedrock due to water-level changes and finally to find suitable ways to inform concerned citizens on the matter. The fact-finding was carried out in the form of interviews, literature surveys, Internet searches and by sending letters to some 60 organisations and researchers asking for co-operation. The most important conclusions are: Earthquake impact during the pre-closure phase: Damage due to shaking in an underground facility may occur if the peak ground acceleration exceeds 2 m/s 2 . Sweden is located in the Baltic Shield that is

  10. Effects of earthquakes on the deep repository for spent fuel in Sweden based on case studies and preliminary model results

    Energy Technology Data Exchange (ETDEWEB)

    Baeckblom, Goeran [Conrox, Djursholm (Sweden); Munier, Raymond [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden)

    2002-06-01

    The Baltic Shield is one of the most stable areas in the world. Earthquakes have only on a few occasions exceeded magnitude 4 in Sweden in modern times. The safety case for a deep repository for spent fuel however includes an earthquake scenario due to the following reason: Earthquakes with much greater magnitudes occurred in northern Sweden during the most recent deglaciation period some 9,000 - 10,000 years ago when re-activated faults ruptured the surface. One of the most prominent evidences is the Paervie fault in Lapland, Sweden. The displacements exceeded 10 m in places and occurred over distances of around 150 km. The deep repository is designed to keep radiation well below the natural, ambient radiation for any time in the future. The safety function is achieved by a combination of engineered and natural barriers. One important safety issue is that future displacements in the rock should be less than 0.1 m at the precise location where the engineered canisters containing the waste are emplaced in the rock. Larger displacements could damage the canister that is designed to be tight for several 100,000 of years. SKB now re-visits the issues of seismic effects on underground facilities to supplement and update previous work. The project Effects of Earthquakes on Underground Facilities aims to re-compile field evidences of seismic damage on underground facilities, to shed additional light on the matter of friction loss in bedrock due to water-level changes and finally to find suitable ways to inform concerned citizens on the matter. The fact-finding was carried out in the form of interviews, literature surveys, Internet searches and by sending letters to some 60 organisations and researchers asking for co-operation. The most important conclusions are: Earthquake impact during the pre-closure phase: Damage due to shaking in an underground facility may occur if the peak ground acceleration exceeds 2 m/s{sup 2}. Sweden is located in the Baltic Shield that is

  11. Personnel Administrators' Preferences for Resume Content: A Survey and Review of Empirically Based Conclusions.

    Science.gov (United States)

    Hutchinson, Kevin L.

    1984-01-01

    Reports results of a survey of Fortune 500 personnel administrators' preferences for the content of resumes submitted by college students entering the job market. Concludes that textbooks, teachers, and applicants should not only include but stress this preferred content. (PD)

  12. Preliminary assessment of late quaternary vegetation and climate of southeastern Utah based on analyses of packrat middens

    International Nuclear Information System (INIS)

    Betancourt, J.L.; Biggar, N.

    1985-06-01

    Packrat midden sequences from two caves (elevations 1585 and 2195 m; 5200 and 7200 ft) southwest of the Abajo Mountains in southeast Utah record vegetation changes that are attributed to climatic changes occurring during the last 13,000 years. These data are useful in assessing potential future climates at proposed nuclear waste sites in the area. Paleoclimates are reconstructed by defining modern elevational analogs for the vegetation assemblages identified in the middens. Based on the midden record, a climate most extreme from the present occurred prior to approximately 10,000 years before present (BP), when mean annual temperature was probably 3 to 4C (5.5 to 7F) cooler than present. However, cooling could not have exceeded 5C (9F) at 1585 m (5200 ft). Accompanying mean annual precipitation is estimated to have been from 35 to 140% greater than at present, with rainfall concentrated in the winter months. Vegetational changes beginning approximately 10,000 years BP are attributed to increased summer and mean annual temperatures, a decreasing frequency of spring freezes, and a shift from winter- to summer-dominant rainfall. Greater effective moisture than present is inferred at both cave sites from approximately 8000 to 4000 years BP. Modern flora was present at both sites by about 2000 years BP

  13. Results of treatment with concurrent radiotherapy and cisplatin-based chemotherapy for cancer of the uterine cervix - a preliminary assessment

    International Nuclear Information System (INIS)

    Rusiecka, M.; Dryl, B.; Bojarowska, K.; Slocka, B.; Ziemba, B.

    2002-01-01

    To compare results of radiochemotherapy and radiotherapy in patients with cervical cancer. Fifty three patients with locally advanced cervical cancer, undergoing combined radiochemotherapy (C) and a control group of 50 patients treated with irradiation only (R) entered the study. All patients in group C treated with concurrent radiochemotherapy showed positive therapeutic effect - no cases of stable disease nor progress. Complete remission (CR) was observed in more than half of the cases (54.72 %) directly after treatment, as compared with group R - 19.64%. However, more than 70% of patients treated with combined therapy demonstrated bone-marrow damages. Only 4 of these patients (7.55%) did not complete cytostatic treatment because of thrombocytopoenia. Low thrombocyte count caused permanent exclusion of the patient from the chemotherapy schedule. Post-irradiation side effects, such as proctitis, urocystis and enterocolitis posed another problem: combined radiochemotherapy increased the percentage of patients with post-irradiation reactions, although the intensity of these reactions was neither increased nor lenghtier. Our results of combining irradiation with cisplatin-based chemotherapy treatment allow to recommend this schedule of therapy as a standard for locally advanced cervical cancer treatment. (author)

  14. Preliminary Investigation of Workplace-Provided Compressed Mindfulness-Based Stress Reduction with Pediatric Medical Social Workers.

    Science.gov (United States)

    Trowbridge, Kelly; Mische Lawson, Lisa; Andrews, Stephanie; Pecora, Jodi; Boyd, Sabra

    2017-11-01

    Mindfulness practices, including mindfulness meditation, show promise for decreasing stress among health care providers. This exploratory study investigates the feasibility of a two-day compressed mindfulness-based stress reduction (cMBSR) course provided in the hospital workplace with pediatric health care social workers. The standard course of Jon Kabat-Zinn's MBSR requires a participant commitment to eight weeks of instruction consisting of one 2.5-hour-per-week class, a single day retreat, and 45 minutes of practice for six of seven days each week. Commitments to family, work, caregiving, education, and so on, as well as limitations such as distance, may prevent health care providers from participating in a standard MBSR course. Using t tests, researchers measured the effect of cMBSR on (a) positive and negative experiences in pediatric social work, (b) perceived stress, (c) mindfulness, and (d) caring self-efficacy (as a component of patient- and family-centered care). Results included significant differences between the pre- and post-intervention outcome variables on the Professional Quality of Life Secondary Traumatic Stress subscale, the Mindful Attention and Awareness Scale, and the Caring Efficacy Scale. Findings found adequate evidence for the feasibility of cMBSR design and for a need of a more rigorous study of the effects of the cMBSR intervention. © 2017 National Association of Social Workers.

  15. Piroxicam and intracavitary platinum-based chemotherapy for the treatment of advanced mesothelioma in pets: preliminary observations

    Directory of Open Access Journals (Sweden)

    Citro Gennaro

    2008-05-01

    Full Text Available Abstract Malignant Mesothelioma is an uncommon and very aggressive tumor that accounts for 1% of all the deaths secondary to malignancy in humans. Interestingly, this neoplasm has been occasionally described in companion animals as well. Aim of this study was the preclinical evaluation of the combination of piroxicam with platinum-based intracavitary chemotherapy in pets. Three companion animals have been treated in a three years period with this combination. Diagnosis was obtained by ultrasonographic exam of the body cavities that evidenced thickening of the mesothelium. A surgical biopsy further substantiated the diagnosis. After drainage of the malignant effusion from the affected cavity, the patients received four cycles of intracavitary CDDP at the dose of 50 mg/m2 every three weeks if dogs or four cycles of intracavitary carboplatin at the dose of 180 mg/m2 (every 3 weeks if cats, coupled with daily administration of piroxicam at the dose of 0.3 mg/kg. The therapy was able to arrest the effusion in all patients for variable remission times: one dog is still in remission after 3 years, one dog died of progressive disease after 8 months and one cat died due to progressive neoplastic growth after six months, when the patient developed a mesothelial cuirass. The combination showed remarkable efficacy at controlling the malignant effusion secondary to MM in our patients and warrants further investigations.

  16. Leptin, insulin and body composition changes during adjuvant taxane based chemotherapy in patients with breast cancer, preliminary study.

    Science.gov (United States)

    Alacacioglu, A; Kebapcilar, L; Gokgoz, Z; Oztekin, O; Bozkaya, G; Tarhan, O; Somali, I; Yuksel, A; Sop, G; Sari, I

    2016-01-01

    The objectives of the present study were to compare the effect of adjuvant chemotherapy for breast cancer on serum insulin levels, serum leptin levels, and body composition in early stage breast cancer patients. 17 breast cancer patients underwent 6 cycles of docetaxel (75 mg), epirubicine (100 mg) and cyclophosphamide (500 mg) (TEC). Anthropometrical and foot-to-foot body fat analyzer BIA, serum glucose, insulin, lipids, HOMA-IR and leptin were compared pre- and post-treatment. There was no statistically significant weight gain after treatment; however, there was an overall trend toward weight gain (69.7 ± 9.8 kg vs 71.03 ± 9.8; P= 0.05). From baseline to the end of the study, percentage of body fat and body fat mass showed an upward trend at the end of chemotherapy (1%; 2 kg P> 0.05). Pre and post-treatment period, leptin was strongly correlated with insulin and HOMA-IR (Spearman's pre-T; r = 0.74; P cancer outcome, and insulin resistance may be increased in taxane based chemotherapy regimen. These data may have broad implications for diet and lifestyle strategies for the prevention and treatment of cancers.

  17. Preliminary considerations of an intense slow positron facility based on a 78Kr loop in the high flux isotopes reactor

    International Nuclear Information System (INIS)

    Hulett, L.D. Jr.; Donohue, D.L.; Peretz, F.J.; Montgomery, B.H.; Hayter, J.B.

    1990-01-01

    Suggestions have been made to the National Steering Committee for the Advanced Neutron Source (ANS) by Mills that provisions be made to install a high intensity slow positron facility, based on a 78 Kr loop, that would be available to the general community of scientists interested in this field. The flux of thermal neutrons calculated for the ANS is E + 15 sec -1 m -2 , which Mills has estimated will produce 5 mm beam of slow positrons having a current of about 1 E + 12 sec -1 . The intensity of such a beam will be a least 3 orders of magnitude greater than those presently available. The construction of the ANS is not anticipated to be complete until the year 2000. In order to properly plan the design of the ANS, strong considerations are being given to a proof-of-principle experiment, using the presently available High Flux Isotopes Reactor, to test the 78 Kr loop technique. The positron current from the HFIR facility is expected to be about 1 E + 10 sec -1 , which is 2 orders of magnitude greater than any other available. If the experiment succeeds, a very valuable facility will be established, and important formation will be generated on how the ANS should be designed. 3 refs., 1 fig

  18. Piroxicam and intracavitary platinum-based chemotherapy for the treatment of advanced mesothelioma in pets: preliminary observations

    Science.gov (United States)

    Spugnini, Enrico P; Crispi, Stefania; Scarabello, Alessandra; Caruso, Giovanni; Citro, Gennaro; Baldi, Alfonso

    2008-01-01

    Malignant Mesothelioma is an uncommon and very aggressive tumor that accounts for 1% of all the deaths secondary to malignancy in humans. Interestingly, this neoplasm has been occasionally described in companion animals as well. Aim of this study was the preclinical evaluation of the combination of piroxicam with platinum-based intracavitary chemotherapy in pets. Three companion animals have been treated in a three years period with this combination. Diagnosis was obtained by ultrasonographic exam of the body cavities that evidenced thickening of the mesothelium. A surgical biopsy further substantiated the diagnosis. After drainage of the malignant effusion from the affected cavity, the patients received four cycles of intracavitary CDDP at the dose of 50 mg/m2 every three weeks if dogs or four cycles of intracavitary carboplatin at the dose of 180 mg/m2 (every 3 weeks) if cats, coupled with daily administration of piroxicam at the dose of 0.3 mg/kg. The therapy was able to arrest the effusion in all patients for variable remission times: one dog is still in remission after 3 years, one dog died of progressive disease after 8 months and one cat died due to progressive neoplastic growth after six months, when the patient developed a mesothelial cuirass. The combination showed remarkable efficacy at controlling the malignant effusion secondary to MM in our patients and warrants further investigations. PMID:18577247

  19. Preliminary seismic design cost-benefit assessment of the tuff repository waste-handling facilities

    International Nuclear Information System (INIS)

    Subramanian, C.V.; Abrahamson, N.; Hadjian, A.H.

    1989-02-01

    This report presents a preliminary assessment of the costs and benefits associated with changes in the seismic design basis of waste-handling facilities. The objectives of the study are to understand the capability of the current seismic design of the waste-handling facilities to mitigate seismic hazards, evaluate how different design levels and design measures might be used toward mitigating seismic hazards, assess the costs and benefits of alternative seismic design levels, and develop recommendations for possible modifications to the seismic design basis. This preliminary assessment is based primarily on expert judgment solicited in an interdisciplinary workshop environment. The estimated costs for individual attributes and the assumptions underlying these cost estimates (seismic hazard levels, fragilities, radioactive-release scenarios, etc.) are subject to large uncertainties, which are generally identified but not treated explicitly in this preliminary analysis. The major conclusions of the report do not appear to be very sensitive to these uncertainties. 41 refs., 51 figs., 35 tabs

  20. Preliminary Analysis of Reinforced Concrete Waffle Walls

    National Research Council Canada - National Science Library

    Shugar, Theodore

    1997-01-01

    A preliminary analytical method based upon modified plate bending theory is offered for structural analysis of a promising new construction method for walls of small buildings and residential housing...

  1. Jumping to the wrong conclusions? An investigation of the mechanisms of reasoning errors in delusions.

    Science.gov (United States)

    Jolley, Suzanne; Thompson, Claire; Hurley, James; Medin, Evelina; Butler, Lucy; Bebbington, Paul; Dunn, Graham; Freeman, Daniel; Fowler, David; Kuipers, Elizabeth; Garety, Philippa

    2014-10-30

    Understanding how people with delusions arrive at false conclusions is central to the refinement of cognitive behavioural interventions. Making hasty decisions based on limited data ('jumping to conclusions', JTC) is one potential causal mechanism, but reasoning errors may also result from other processes. In this study, we investigated the correlates of reasoning errors under differing task conditions in 204 participants with schizophrenia spectrum psychosis who completed three probabilistic reasoning tasks. Psychotic symptoms, affect, and IQ were also evaluated. We found that hasty decision makers were more likely to draw false conclusions, but only 37% of their reasoning errors were consistent with the limited data they had gathered. The remainder directly contradicted all the presented evidence. Reasoning errors showed task-dependent associations with IQ, affect, and psychotic symptoms. We conclude that limited data-gathering contributes to false conclusions but is not the only mechanism involved. Delusions may also be maintained by a tendency to disregard evidence. Low IQ and emotional biases may contribute to reasoning errors in more complex situations. Cognitive strategies to reduce reasoning errors should therefore extend beyond encouragement to gather more data, and incorporate interventions focused directly on these difficulties. Copyright © 2014 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

  2. Usefulness of StereoEEG-based tailored surgery for medial temporal lobe epilepsy. Preliminary results in 11 patients.

    Science.gov (United States)

    Kubota, Yuichi; Ochiai, Taku; Hori, Tomokatsu; Kawamata, Takakazu

    2017-07-01

    Surgical options for medial temporal lobe epilepsy (MTLE) include anterior temporal lobectomy (ATL) and selective amygdalohippocampectomy (SAH). Optimal criteria for choosing the appropriate surgical approach remain uncertain. This article reports 11 consecutive cases in which electrophysiological findings of stereoelectroencephalography (SEEG) were used to determine the optimal surgical approach. Eleven consecutive patients with MTLE underwent SEEG evaluation and were placed in either the medial or the medial+lateral group based on the findings. Patients in the medial group underwent SAH using the subtemporal approach, and patients in the medial+lateral group underwent SEEG-guided anterior temporal lobectomy. SEEG findings were also compared with other examinations including flumazenil (FMZ)-positron emission tomography (PET), fluorine-18 labeled fluorodeoxyglucose (FDG)-PET, and magnetoencephalography (MEG). Results were evaluated to determine which examinations most consistently identified the epileptogenic zone. Of the 11 cases, 4 patients were placed in the medial group, and 7 patients in the medial+lateral group. Of patients, 90.9% were classified in class I of the Engel Epilepsy Surgery Outcome Scale, while 72.7% were classified in class I by the International League Against Epilepsy (ILAE) system. Analyzed by group, 100% of the medial group experienced an Engel class I outcome in the medial group, compared to 85.7% in the medial+lateral group. SEEG findings were comparable with FDG-PET results (10 of 11, 91%). Tailored surgery guided by SEEG is an electrophysiologically feasible treatment for MTLE that can result in favorable outcomes. Although seizures are thought to originate in the medial temporal lobe in MTLE, it is important for involvement of the lateral temporal cortex to be also considered in some cases. Copyright © 2017. Published by Elsevier B.V.

  3. Studies on medicinal herbs for cognitive enhancement based on the text mining of Dongeuibogam and preliminary evaluation of its effects.

    Science.gov (United States)

    Pak, Malk Eun; Kim, Yu Ri; Kim, Ha Neui; Ahn, Sung Min; Shin, Hwa Kyoung; Baek, Jin Ung; Choi, Byung Tae

    2016-02-17

    In literature on Korean medicine, Dongeuibogam (Treasured Mirror of Eastern Medicine), published in 1613, represents the overall results of the traditional medicines of North-East Asia based on prior medicinal literature of this region. We utilized this medicinal literature by text mining to establish a list of candidate herbs for cognitive enhancement in the elderly and then performed an evaluation of their effects. Text mining was performed for selection of candidate herbs. Cell viability was determined in HT22 hippocampal cells and immunohistochemistry and behavioral analysis was performed in a kainic acid (KA) mice model in order to observe alterations of hippocampal cells and cognition. Twenty four herbs for cognitive enhancement in the elderly were selected by text mining of Dongeuibogam. In HT22 cells, pretreatment with 3 candidate herbs resulted in significantly reduced glutamate-induced cell death. Panax ginseng was the most neuroprotective herb against glutamate-induced cell death. In the hippocampus of a KA mice model, pretreatment with 11 candidate herbs resulted in suppression of caspase-3 expression. Treatment with 7 candidate herbs resulted in significantly enhanced expression levels of phosphorylated cAMP response element binding protein. Number of proliferated cells indicated by BrdU labeling was increased by treatment with 10 candidate herbs. Schisandra chinensis was the most effective herb against cell death and proliferation of progenitor cells and Rehmannia glutinosa in neuroprotection in the hippocampus of a KA mice model. In a KA mice model, we confirmed improved spatial and short memory by treatment with the 3 most effective candidate herbs and these recovered functions were involved in a higher number of newly formed neurons from progenitor cells in the hippocampus. These established herbs and their combinations identified by text-mining technique and evaluation for effectiveness may have value in further experimental and clinical

  4. Preliminary analysis of compound systems based on high temperature fuel cell, gas turbine and Organic Rankine Cycle

    Science.gov (United States)

    Sánchez, D.; Muñoz de Escalona, J. M.; Monje, B.; Chacartegui, R.; Sánchez, T.

    This article presents a novel proposal for complex hybrid systems comprising high temperature fuel cells and thermal engines. In this case, the system is composed by a molten carbonate fuel cell with cascaded hot air turbine and Organic Rankine Cycle (ORC), a layout that is based on subsequent waste heat recovery for additional power production. The work will credit that it is possible to achieve 60% efficiency even if the fuel cell operates at atmospheric pressure. The first part of the analysis focuses on selecting the working fluid of the Organic Rankine Cycle. After a thermodynamic optimisation, toluene turns out to be the most efficient fluid in terms of cycle performance. However, it is also detected that the performance of the heat recovery vapour generator is equally important, what makes R245fa be the most interesting fluid due to its balanced thermal and HRVG efficiencies that yield the highest global bottoming cycle efficiency. When this fluid is employed in the compound system, conservative operating conditions permit achieving 60% global system efficiency, therefore accomplishing the initial objective set up in the work. A simultaneous optimisation of gas turbine (pressure ratio) and ORC (live vapour pressure) is then presented, to check if the previous results are improved or if the fluid of choice must be replaced. Eventually, even if system performance improves for some fluids, it is concluded that (i) R245fa is the most efficient fluid and (ii) the operating conditions considered in the previous analysis are still valid. The work concludes with an assessment about safety-related aspects of using hydrocarbons in the system. Flammability is studied, showing that R245fa is the most interesting fluid also in this regard due to its inert behaviour, as opposed to the other fluids under consideration all of which are highly flammable.

  5. Dental Erosion and Dentin Hypersensitivity among Adult Asthmatics and Non-asthmatics Hospital-based: A Preliminary Study.

    Science.gov (United States)

    Farag, Zahra Hassan Abdelaziz; Awooda, Elhadi Mohieldin

    2016-01-01

    Asthma is a chronic inflammatory condition affecting the airways leading to spasm and swelling of the airways. The medications taken for the treatment of asthma can result in dental erosion and dentin hypersensitivity. The aims of this study were to investigate the severity of dental erosion amongst adult asthmatics according to: gender, type and duration of medication taken and to compare dental erosion and dentin hypersensitivity between asthmatics and non-asthmatics. Comparative, cross-sectional hospital based study among 40 asthmatics (M=15 & F=25) and 40 non-asthmatics (M=18 & F=22) in the age range of 18-60 year selected purposefully from Al-Shaab Teaching Hospital in Khartoum city. The Basic Erosive Wear Index was used for dental erosion assessment. Dentine hypersensitivity was determined by giving ice cold water and rated using the Visual Analogue Scale. Chi-square and Student's t-test were used for statistical analysis with P value ≤.05. There was an association between severity of dental erosion and presence of asthma (P=0.03), where asthmatics had a higher degree of erosion (moderate and severe) and non-asthmatics a lower degree. No significant association was found between dental erosion and gender, type and duration of medication among asthmatics group. A statistically significant difference was revealed in the degree of dentin hypersensitivity (P=0.00) among asthmatics (35.13%) and non-asthmatics (14.13%). Asthmatic patients had a higher degree of dental erosion and dentin hypersensitivity compared to non-asthmatics. Among asthmatic patients there was no association between severity of dental erosion and gender, type and duration medication was taken for.

  6. Psycho-physiological assessment of a prosthetic hand sensory feedback system based on an auditory display: a preliminary study.

    Science.gov (United States)

    Gonzalez, Jose; Soma, Hirokazu; Sekine, Masashi; Yu, Wenwei

    2012-06-09

    Prosthetic hand users have to rely extensively on visual feedback, which seems to lead to a high conscious burden for the users, in order to manipulate their prosthetic devices. Indirect methods (electro-cutaneous, vibrotactile, auditory cues) have been used to convey information from the artificial limb to the amputee, but the usability and advantages of these feedback methods were explored mainly by looking at the performance results, not taking into account measurements of the user's mental effort, attention, and emotions. The main objective of this study was to explore the feasibility of using psycho-physiological measurements to assess cognitive effort when manipulating a robot hand with and without the usage of a sensory substitution system based on auditory feedback, and how these psycho-physiological recordings relate to temporal and grasping performance in a static setting. 10 male subjects (26+/-years old), participated in this study and were asked to come for 2 consecutive days. On the first day the experiment objective, tasks, and experiment setting was explained. Then, they completed a 30 minutes guided training. On the second day each subject was tested in 3 different modalities: Auditory Feedback only control (AF), Visual Feedback only control (VF), and Audiovisual Feedback control (AVF). For each modality they were asked to perform 10 trials. At the end of each test, the subject had to answer the NASA TLX questionnaire. Also, during the test the subject's EEG, ECG, electro-dermal activity (EDA), and respiration rate were measured. The results show that a higher mental effort is needed when the subjects rely only on their vision, and that this effort seems to be reduced when auditory feedback is added to the human-machine interaction (multimodal feedback). Furthermore, better temporal performance and better grasping performance was obtained in the audiovisual modality. The performance improvements when using auditory cues, along with vision

  7. Environmental and ice volume changes based on seismic stratigraphy in Sabrina Coast, East Antarctica: Preliminary results from NBP1402

    Science.gov (United States)

    Gulick, S. P. S.; Fernandez-Vasquez, R. A.; Frederick, B.; Saustrup, S., Sr.; Domack, E. W.; Lavoie, C.; Shevenell, A.; Blankenship, D. D.; Leventer, A.

    2014-12-01

    . The unconformity is overlain by glacial diamict, representing an incomplete record of cold-based glaciations after the ASB became ice-filled. Correlations with cores collected above and below the unconformity and deltaic unit should allow us to determine the ages of these transitions from fluvial to polythermal to ice sheets in East Antarctica.

  8. Preliminary Sizing Completed for Single- Stage-To-Orbit Launch Vehicles Powered By Rocket-Based Combined Cycle Technology

    Science.gov (United States)

    Roche, Joseph M.

    2002-01-01

    Single-stage-to-orbit (SSTO) propulsion remains an elusive goal for launch vehicles. The physics of the problem is leading developers to a search for higher propulsion performance than is available with all-rocket power. Rocket-based combined cycle (RBCC) technology provides additional propulsion performance that may enable SSTO flight. Structural efficiency is also a major driving force in enabling SSTO flight. Increases in performance with RBCC propulsion are offset with the added size of the propulsion system. Geometrical considerations must be exploited to minimize the weight. Integration of the propulsion system with the vehicle must be carefully planned such that aeroperformance is not degraded and the air-breathing performance is enhanced. Consequently, the vehicle's structural architecture becomes one with the propulsion system architecture. Geometrical considerations applied to the integrated vehicle lead to low drag and high structural and volumetric efficiency. Sizing of the SSTO launch vehicle (GTX) is itself an elusive task. The weight of the vehicle depends strongly on the propellant required to meet the mission requirements. Changes in propellant requirements result in changes in the size of the vehicle, which in turn, affect the weight of the vehicle and change the propellant requirements. An iterative approach is necessary to size the vehicle to meet the flight requirements. GTX Sizer was developed to do exactly this. The governing geometry was built into a spreadsheet model along with scaling relationships. The scaling laws attempt to maintain structural integrity as the vehicle size is changed. Key aerodynamic relationships are maintained as the vehicle size is changed. The closed weight and center of gravity are displayed graphically on a plot of the synthesized vehicle. In addition, comprehensive tabular data of the subsystem weights and centers of gravity are generated. The model has been verified for accuracy with finite element analysis. The

  9. A preliminary RCT of a mind body skills based intervention addressing mood and coping strategies in patients with acute orthopaedic trauma.

    Science.gov (United States)

    Vranceanu, Ana-Maria; Hageman, Michiel; Strooker, Joost; ter Meulen, Dirk; Vrahas, Mark; Ring, David

    2015-04-01

    To test the acceptability and feasibility of a mind body skills-based intervention (RRCB) and estimate its preliminary effect in reducing disability and pain intensity as compared to standard care (SC) in patients with acute musculoskeletal trauma. Randomised controlled trial. Level I trauma centre. Adult patients with acute fractures at risk for chronic pain and disability based on scores on two coping with pain measures who presented to an orthopedic trauma center and met inclusion and exclusion criteria. Participants were randomied to either RRCB with SC or SC alone. Disability (short musculoskeletal functional assessment, SMFA) and pain (Numerical Analogue Scale). coping strategies (Pain Catastrophizing Scale, PCS and Pain Anxiety Scale, PAS) and mood (CESD Depression and PTSD checklist). Among the 50 patients consented, two did not complete the initial assessment. Of these, the first four received the intervention as part of an open pilot and the next 44 were randomised (24 RRCBT and 20 UC) and completed initial assessment. We combined the patients who received RRCB into one group, N=28. Of the entire sample, 34 completed time two assessments (24 RRCBT and 10 SC). The RRCB proved to be feasible and accepted (86% retention, 28 out of 24 completers). Analyses of covariance ANCOVA showed a significant (pstudy variables (.2-.5) except pain with activity where the effect size was medium (.08). Improvement for pain at rest was not significantly higher in the RRCB as compared to the control, for a small effect size (.03). The RRCB is feasible, acceptable and potentially efficacious. Level 1 prognostic. Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. Characteristics of interventional cardiologists and their work practices for the study on radiation-induced lens opacities based on the methodology developed by ELDO—preliminary results

    International Nuclear Information System (INIS)

    Domienik, Joanna; Gryglak, Szymon; Jurewicz, Joanna

    2016-01-01

    Preliminary results of the Polish epidemiology study on eye lens opacities among interventional cardiologists (ICs), based on the methodology proposed by ELDO (epidemiological studies of radio-induced cataracts in interventional cardiologists and radiologists: methodology implementation), are presented. The aim of the study is to test the hypothesis concerning the excess risk of cataract in the group of ICs. The first results concern the study population characteristics, including the most important confounding factors for cataract, as well as a detailed description of the work practices in interventional cardiology needed in order to reconstruct the cumulative eye lens dose. The data from 69 ICs and 23 controls collected based on the general medical questionnaire and the occupational questionnaire (for ICs only) were analyzed. The mean age of ICs and of the control group was 41 and 44, respectively, while the mean duration of work for exposed physicians was 9 years. The analysis of the data from the occupational questionnaire concerning the procedures performed, the use of various access routes, as well as radiation protection tools (eye lens glasses, ceiling suspended transparent shield, etc.) are also presented. On the basis of this information and additional assumptions about the doses per procedure (as well as reduction factors for various types of radiation measures), the cumulative doses to the eye lens of ICs were evaluated. They ranged up to 1.55 Sv and 0.4 Sv for left and right eye, respectively; however, the dose to only 3% of ICs exceeded the new threshold for development of eye lens opacities (0.5 Gy) proposed by the ICRP

  11. Regret and Responsibility Resolved? Evaluating Ordóñez and Connolly's (2000) Conclusions.

    Science.gov (United States)

    Zeelenberg; van Dijk WW; Manstead

    2000-01-01

    T. Connolly, L. D. Ordo;aan;atez, and R. Coughlan (1997, Organizational Behavior and Human Decision Processes, 70, 73-85) argued, on the basis of 5 experiments, that regret need not be related to a sense of responsibility for the regretted outcome. We (M. Zeelenberg, W. W. van Dijk, & A. S. R. Manstead, 1998, Organizational Behavior and Human Decision Processes, 74, 254-272) showed in 2 experiments that this conclusion was premature, because it was based on an indirect measure of regret (i.e., overall happiness with the decision outcome). When regret was directly measured, the predicted effects of responsibility were found. L. D. Ordo;aan;atez and T. Connolly (2000, Organizational Behavior and Human Decision Processes, 81, 132-142) replicated our findings in 2 experiments. Based on their findings they arrived at 4 conclusions. In this rejoinder we first discuss Ordóñez and Connolly's new studies and we then discuss the validity of their 4 conclusions. Copyright 2000 Academic Press.

  12. How often do sensitivity analyses for economic parameters change cost-utility analysis conclusions?

    Science.gov (United States)

    Schackman, Bruce R; Gold, Heather Taffet; Stone, Patricia W; Neumann, Peter J

    2004-01-01

    There is limited evidence about the extent to which sensitivity analysis has been used in the cost-effectiveness literature. Sensitivity analyses for health-related QOL (HR-QOL), cost and discount rate economic parameters are of particular interest because they measure the effects of methodological and estimation uncertainties. To investigate the use of sensitivity analyses in the pharmaceutical cost-utility literature in order to test whether a change in economic parameters could result in a different conclusion regarding the cost effectiveness of the intervention analysed. Cost-utility analyses of pharmaceuticals identified in a prior comprehensive audit (70 articles) were reviewed and further audited. For each base case for which sensitivity analyses were reported (n = 122), up to two sensitivity analyses for HR-QOL (n = 133), cost (n = 99), and discount rate (n = 128) were examined. Article mentions of thresholds for acceptable cost-utility ratios were recorded (total 36). Cost-utility ratios were denominated in US dollars for the year reported in each of the original articles in order to determine whether a different conclusion would have been indicated at the time the article was published. Quality ratings from the original audit for articles where sensitivity analysis results crossed the cost-utility ratio threshold above the base-case result were compared with those that did not. The most frequently mentioned cost-utility thresholds were $US20,000/QALY, $US50,000/QALY, and $US100,000/QALY. The proportions of sensitivity analyses reporting quantitative results that crossed the threshold above the base-case results (or where the sensitivity analysis result was dominated) were 31% for HR-QOL sensitivity analyses, 20% for cost-sensitivity analyses, and 15% for discount-rate sensitivity analyses. Almost half of the discount-rate sensitivity analyses did not report quantitative results. Articles that reported sensitivity analyses where results crossed the cost

  13. The 1993 Finnish Interdisciplinary Seminar on SETI - A review of aims, approaches and conclusions

    Science.gov (United States)

    Seppanen, Jouko

    1993-10-01

    The communications of the International Interdisciplinary Seminar on SETI, held on March 6-7, 1993 in Vantaa, Finland, are reviewed and the contents and conclusions of papers summarized. The seminar was organized jointly by the Finnish Artificial Intelligence Society (FAIS), Finnish Astronomical Society, Ursa Astronomical Association and Heureka - The Finnish Science Centre. As the ninth in a series of intelligence-related seminars of FAIS, SETI was chosen as the topic for spring 1993, noting the new ten year NASA SETI program HRMS (High Resolution Micro-wave Survey), commenced on Columbus Day, October 12, 1992. The aims and the interdisciplinary format of the seminar are described, the main results and conclusions of papers are restated, and the seminar publications introduced. The summaries of papers are based on their abstracts and contain excerpts from texts.

  14. Preliminary Safety Analysis of the Gorleben Site: Safety Concept and Application to Scenario Development Based on a Site-Specific Features, Events and Processes (FEP) Database - 13304

    Energy Technology Data Exchange (ETDEWEB)

    Moenig, Joerg; Beuth, Thomas; Wolf, Jens [Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) mbH, Theodor-Heuss-Str. 4, D-38122 Braunschweig (Germany); Lommerzheim, Andre [DBE TECHNOLOGY GmbH, Eschenstr. 55, D-31224 Peine (Germany); Mrugalla, Sabine [Federal Institute for Geosciences and Natural Resources (BGR), Stilleweg 2, D-30655 Hannover (Germany)

    2013-07-01

    Based upon the German safety criteria, released in 2010 by the Federal Ministry of the Environment (BMU), a safety concept and a safety assessment concept for the disposal of heat-generating high-level waste have both been developed in the framework of the preliminary safety case for the Gorleben site (Project VSG). The main objective of the disposal is to contain the radioactive waste inside a defined rock zone, which is called containment-providing rock zone. The radionuclides shall remain essentially at the emplacement site, and at the most, a small defined quantity of material shall be able to leave this rock zone. This shall be accomplished by the geological barrier and a technical barrier system, which is required to seal the inevitable penetration of the geological barrier by the construction of the mine. The safe containment has to be demonstrated for probable and less probable evolutions of the site, while evolutions with very low probability (less than 1 % over the demonstration period of 1 million years) need not to be considered. Owing to the uncertainty in predicting the real evolution of the site, plausible scenarios have been derived in a systematic manner. Therefore, a comprehensive site-specific features, events and processes (FEP) data base for the Gorleben site has been developed. The safety concept was directly taken into account, e.g. by identification of FEP with direct influence on the barriers that provide the containment. No effort was spared to identify the interactions of the FEP, their probabilities of occurrence, and their characteristics (values). The information stored in the data base provided the basis for the development of scenarios. The scenario development methodology is based on FEP related to an impairment of the functionality of a subset of barriers, called initial barriers. By taking these FEP into account in their probable characteristics the reference scenario is derived. Thus, the reference scenario describes a

  15. First high speed imaging of lightning from summer thunderstorms over India: Preliminary results based on amateur recording using a digital camera

    Science.gov (United States)

    Narayanan, V. L.

    2017-12-01

    For the first time, high speed imaging of lightning from few isolated tropical thunderstorms are observed from India. The recordings are made from Tirupati (13.6oN, 79.4oE, 180 m above mean sea level) during summer months with a digital camera capable of recording high speed videos up to 480 fps. At 480 fps, each individual video file is recorded for 30 s resulting in 14400 deinterlaced images per video file. An automatic processing algorithm is developed for quick identification and analysis of the lightning events which will be discussed in detail. Preliminary results indicating different types of phenomena associated with lightning like stepped leader, dart leader, luminous channels corresponding to continuing current and M components are discussed. While most of the examples show cloud to ground discharges, few interesting cases of intra-cloud, inter-cloud and cloud-air discharges will also be displayed. This indicates that though high speed cameras with few 1000 fps are preferred for a detailed study on lightning, moderate range CMOS sensor based digital cameras can provide important information as well. The lightning imaging activity presented herein is initiated as an amateur effort and currently plans are underway to propose a suite of supporting instruments to conduct coordinated campaigns. The images discussed here are acquired from normal residential area and indicate how frequent lightning strikes are in such tropical locations during thunderstorms, though no towering structures are nearby. It is expected that popularizing of such recordings made with affordable digital cameras will trigger more interest in lightning research and provide a possible data source from amateur observers paving the way for citizen science.

  16. Preliminary assessment of the computer-based Taenia solium educational program 'The Vicious Worm' on knowledge uptake in primary school students in rural areas in eastern Zambia.

    Science.gov (United States)

    Hobbs, Emma C; Mwape, Kabemba Evans; Van Damme, Inge; Berkvens, Dirk; Zulu, Gideon; Mambwe, Moses; Chembensofu, Mwelwa; Phiri, Isaac Khozozo; Masuku, Maxwell; Bottieau, Emmanuel; Devleesschauwer, Brecht; Speybroeck, Niko; Colston, Angela; Dorny, Pierre; Willingham, Arve Lee; Gabriël, Sarah

    2018-03-01

    The zoonotic helminth Taenia solium is endemic in Zambia, causing human (taeniasis and (neuro)cysticercosis) and pig (porcine cysticercosis) diseases with high health, social and economic burdens. We aimed to evaluate the impact of a health educational program intended to lead to powerful and cumulative improvements in knowledge, attitudes and practices that decrease parasite transmission and disease occurrence. Half-day health education workshops were conducted in three primary schools in the highly endemic Eastern Province of Zambia, using the computer-based T. solium educational program 'The Vicious Worm'. Questionnaires were administered before and after the educational component to determine the program's impact on knowledge uptake in primary school students. In total, 99 students participated: 38 males and 61 females, with a median age of 14 years (range 10-18 years). Baseline general knowledge of T. solium, including awareness of the different human and pig disease states, and disease diagnosis, treatment and prevention, was quite high (average score 62%) and consistent across all three study areas. Participants' knowledge had significantly increased after the educational component, particularly regarding parasite transmission and disease prevention. Preliminary assessment of 'The Vicious Worm' indicates it is an effective tool for the short-term T. solium education of primary school students in Zambia. Follow-up studies are planned to assess the longer term impact of the program on knowledge uptake in the study neighbourhoods. Inclusion of tailored 'The Vicious Worm' educational workshops should be considered in integrated cysticercosis control programs in endemic areas of sub-Saharan Africa. © 2018 The Authors. Tropical Medicine & International Health Published by John Wiley & Sons Ltd.

  17. Use of a single implant to retain mandibular overdenture: A preliminary clinical trial of 13 cases

    Directory of Open Access Journals (Sweden)

    Tao Cheng

    2012-09-01

    Conclusion: Within the limitations of this preliminary prospective clinical study, single-implant-supported mandibular overdentures were a successful alternative treatment option for elderly edentulous patients.

  18. Jumping to the wrong conclusions? An investigation of the mechanisms of reasoning errors in delusions

    Science.gov (United States)

    Jolley, Suzanne; Thompson, Claire; Hurley, James; Medin, Evelina; Butler, Lucy; Bebbington, Paul; Dunn, Graham; Freeman, Daniel; Fowler, David; Kuipers, Elizabeth; Garety, Philippa

    2014-01-01

    Understanding how people with delusions arrive at false conclusions is central to the refinement of cognitive behavioural interventions. Making hasty decisions based on limited data (‘jumping to conclusions’, JTC) is one potential causal mechanism, but reasoning errors may also result from other processes. In this study, we investigated the correlates of reasoning errors under differing task conditions in 204 participants with schizophrenia spectrum psychosis who completed three probabilistic reasoning tasks. Psychotic symptoms, affect, and IQ were also evaluated. We found that hasty decision makers were more likely to draw false conclusions, but only 37% of their reasoning errors were consistent with the limited data they had gathered. The remainder directly contradicted all the presented evidence. Reasoning errors showed task-dependent associations with IQ, affect, and psychotic symptoms. We conclude that limited data-gathering contributes to false conclusions but is not the only mechanism involved. Delusions may also be maintained by a tendency to disregard evidence. Low IQ and emotional biases may contribute to reasoning errors in more complex situations. Cognitive strategies to reduce reasoning errors should therefore extend beyond encouragement to gather more data, and incorporate interventions focused directly on these difficulties. PMID:24958065

  19. Ecological risk assessment on a cadmium contaminated soil landfill-a preliminary evaluation based on toxicity tests on local species and site-specific information

    International Nuclear Information System (INIS)

    Chen, C.-M.; Liu, M.-C.

    2006-01-01

    In recent years, methodology of ecological risk assessment has been developed and applied frequently for addressing various circumstances where ecological impacts are suspected or have occurred due to environmental contamination; however, its practice is very limited in Taiwan. In 1982, brown rice from rice paddy fields in Da-Tan, Tau-Yuan, was found to be contaminated with Cd and Pb due to illegal discharges of wastewater, known as the 'Cd rice' incidence. Cadmium laden soil was transferred to a constructed landfill in an industrial park 15 years after the incident. Possible leakage of the landfill was suspected by committee members of a supervising board for the remediation process, and a preliminary ecological risk evaluation was requested. A possible risk scenario was that groundwater contamination due to the leachate containing Cd and Pb from the landfill could result in pollution of coastal water, and subsequently produce toxic effects to aquatic organisms. Chemical dissipation in groundwater systems was simulated and short-term chronic toxicity tests on larvae of three local aquatic species were also performed to determine the no-observed adverse-effect concentrations (NOAECs), as well as the predicted no effect concentrations (PNECs), of the two metals in the organisms tested. The hazard quotient (HQ), the ratio of predicted environmental concentrations (PECs) to PNECs, was used for risk characterization. A worst-case-scenario calculation showed that the maximum Cd concentration at 60 m and farther downstream from the site in the groundwater system would be 0.0028 mg l -1 with a maximum initial concentration of 0.65 mg l -1 in the leachate, while for Pb, the highest concentration of 0.044 mg l -1 would be reached at a distance of 40 m and farther, which was based on an initial concentration of 4.4 mg l -1 in the leachate; however, both cases would only occur 80 years after the initiation of leakage. A presumed dilution factor of 100 was used to calculate

  20. Building-related symptoms among U.S. office workers and risks factors for moisture and contamination: Preliminary analyses of U.S. EPA BASE Data

    Energy Technology Data Exchange (ETDEWEB)

    Mendell, Mark J.; Cozen, Myrna

    2002-09-01

    The authors assessed relationships between health symptoms in office workers and risk factors related to moisture and contamination, using data collected from a representative sample of U.S. office buildings in the U.S. EPA BASE study. Methods: Analyses assessed associations between three types of weekly, workrelated symptoms-lower respiratory, mucous membrane, and neurologic-and risk factors for moisture or contamination in these office buildings. Multivariate logistic regression models were used to estimate the strength of associations for these risk factors as odds ratios (ORs) adjusted for personal-level potential confounding variables related to demographics, health, job, and workspace. A number of risk factors were associated (e.g., 95% confidence limits excluded 1.0) significantly with small to moderate increases in one or more symptom outcomes. Significantly elevated ORs for mucous membrane symptoms were associated with the following risk factors: presence of humidification system in good condition versus none (OR = 1.4); air handler inspection annually versus daily (OR = 1.6); current water damage in the building (OR = 1.2); and less than daily vacuuming in study space (OR = 1.2). Significantly elevated ORs for lower respiratory symptoms were associated with: air handler inspection annually versus daily (OR = 2.0); air handler inspection less than daily but at least semi-annually (OR=1.6); less than daily cleaning of offices (1.7); and less than daily vacuuming of the study space (OR = 1.4). Only two statistically significant risk factors for neurologic symptoms were identified: presence of any humidification system versus none (OR = 1.3); and less than daily vacuuming of the study space (OR = 1.3). Dirty cooling coils, dirty or poorly draining drain pans, and standing water near outdoor air intakes, evaluated by inspection, were not identified as risk factors in these analyses, despite predictions based on previous findings elsewhere, except that very

  1. Acceptability and preliminary feasibility of an internet/CD-ROM-based education and decision program for early-stage prostate cancer patients: randomized pilot study.

    Science.gov (United States)

    Diefenbach, Michael A; Mohamed, Nihal E; Butz, Brian P; Bar-Chama, Natan; Stock, Richard; Cesaretti, Jamie; Hassan, Waleed; Samadi, David; Hall, Simon J

    2012-01-13

    Prostate cancer is the most common cancer affecting men in the United States. Management options for localized disease exist, yet an evidence-based criterion standard for treatment still has to emerge. Although 5-year survival rates approach 98%, all treatment options carry the possibility for significant side effects, such as erectile dysfunction and urinary incontinence. It is therefore recommended that patients be actively involved in the treatment decision process. We have developed an Internet/CD-ROM-based multimedia Prostate Interactive Educational System (PIES) to enhance patients' treatment decision making. PIES virtually mirrors a health center to provide patients with information about prostate cancer and its treatment through an intuitive interface, using videos, animations, graphics, and texts. (1) To examine the acceptability and feasibility of the PIES intervention and to report preliminary outcomes of the program in a pilot trial among patients with a new prostate cancer diagnosis, and (2) to explore the potential impact of tailoring PIES treatment information to participants' information-seeking styles on study outcomes. Participants (n = 72) were patients with newly diagnosed localized prostate cancer who had not made a treatment decision. Patients were randomly assigned to 3 experimental conditions: (1) control condition (providing information through standard National Cancer Institute brochures; 26%), and PIES (2) with tailoring (43%) and (3) without tailoring to a patient's information-seeking style (31%). Questionnaires were administrated before (t1) and immediately after the intervention (t2). Measurements include evaluation and acceptability of the PIES intervention, monitoring/blunting information-seeking style, psychological distress, and decision-related variables (eg, decisional confidence, feeling informed about prostate cancer and treatment, and treatment preference). The PIES program was well accepted by patients and did not interfere

  2. Preliminary evaluation of the impact of a Web-based HIV testing programme in Abruzzo Region on the prevention of late HIV presentation and associated mortality

    Directory of Open Access Journals (Sweden)

    Ennio Polilli

    2018-04-01

    Full Text Available Objective: This study aimed to analyze the efficacy of a Web-based testing programme in terms of the prevention of late HIV presentation. The clinical characteristics of patients diagnosed with HIV via the Web-based testing programme were compared to those of patients diagnosed in parallel via standard diagnostic care procedures. Methods: This study included the clinical and demographic data of newly diagnosed HIV patients enrolled at the study clinic between February 2014 and June 2017. These patients were diagnosed either via standard diagnostic procedures or as a result of the Web-based testing programme. Results: Eighty-eight new cases of HIV were consecutively enrolled; their mean age was 39.1 ± 13.0 years. Fifty-nine patients (67% were diagnosed through standard diagnostic procedures and 29 (33% patients came from the Web-based testing programme. Late presentation (62% vs. 34%, p = 0.01 and AIDS-defining conditions at presentation (13 vs. 1, p = 0.02 were significantly more frequent in the standard care group than in the Web-based group; four of 13 patients with AIDS diagnosed under standard diagnostic procedures died, versus none in the Web-based testing group (p < 0.001. Conclusions: Web-based recruitment for voluntary and free HIV testing helped to diagnose patients with less advanced HIV disease and no risk of death, from all at-risk groups, in comparison with standard care testing. Keywords: AIDS, HIV, Late presentation, Voluntary and free testing, HIV diagnosis, Sexually transmitted infections

  3. Health of the coral reefs at the US Navy Base, Guantánamo Bay, Cuba: A preliminary report based on isotopic records from gorgonians

    International Nuclear Information System (INIS)

    Risk, Michael J.; Burchell, Meghan; Brunton, Dalston A.; McCord, Michael R.

    2014-01-01

    Specimens of the gorgonian Plexaura homomalla were sampled from several areas along the fringing reefs fronting the United States Naval Base at Guantánamo Bay, Cuba. Sample coverage extended from apparently healthy reefs in oceanic waters to declining reefs located in the plume of the drainage from upper parts of Guantánamo Bay. Tentacle tips were excised, and trunk sections were cut and polished. Stable isotope ratios of nitrogen (δ 15 N) and carbon indicate a strong correlation of reef health with proximity to the plume of the river. Of all the worldwide cases in which land-based sources of pollution have impacted reefs, this one may well be the most intractable. The US Navy has jurisdiction over the reefs, with the obligation to protect them, yet the threat comes down the river from Cuba

  4. Health of the coral reefs at the US Navy Base, Guantánamo Bay, Cuba: a preliminary report based on isotopic records from gorgonians.

    Science.gov (United States)

    Risk, Michael J; Burchell, Meghan; Brunton, Dalston A; McCord, Michael R

    2014-06-15

    Specimens of the gorgonian Plexaura homomalla were sampled from several areas along the fringing reefs fronting the United States Naval Base at Guantánamo Bay, Cuba. Sample coverage extended from apparently healthy reefs in oceanic waters to declining reefs located in the plume of the drainage from upper parts of Guantánamo Bay. Tentacle tips were excised, and trunk sections were cut and polished. Stable isotope ratios of nitrogen (δ(15)N) and carbon indicate a strong correlation of reef health with proximity to the plume of the river. Of all the worldwide cases in which land-based sources of pollution have impacted reefs, this one may well be the most intractable. The US Navy has jurisdiction over the reefs, with the obligation to protect them, yet the threat comes down the river from Cuba. Copyright © 2014 Elsevier Ltd. All rights reserved.

  5. Preliminary comparison of the Essie and PubMed search engines for answering clinical questions using MD on Tap, a PDA-based program for accessing biomedical literature.

    Science.gov (United States)

    Sutton, Victoria R; Hauser, Susan E

    2005-01-01

    MD on Tap, a PDA application that searches and retrieves biomedical literature, is specifically designed for use by mobile healthcare professionals. With the goal of improving the usability of the application, a preliminary comparison was made of two search engines (PubMed and Essie) to determine which provided most efficient path to the desired clinically-relevant information.

  6. Efficacy of Barium-Based Fecal Tagging for CT Colonography: a Comparison between the Use of High and Low Density Barium Suspensions in a Korean Population - a Preliminary Study

    Science.gov (United States)

    Kim, Min Ju; Lee, Seung Soo; Byeon, Jeong-Sik; Choi, Eugene K.; Kim, Jung Hoon; Kim, Yeoung Nam; Kim, Ah Young; Ha, Hyun Kwon

    2009-01-01

    Objective This preliminarily study was designed to determine and to compare the efficacy of two commercially available barium-based fecal tagging agents for CT colonography (CTC) (high-density [40% w/v] and low-density [4.6% w/v] barium suspensions) in a population in Korea. Materials and Methods In a population with an identified with an average-risk for colorectal cancer, 15 adults were administered three doses of 20 ml 40% w/v barium for fecal tagging (group I) and 15 adults were administered three doses of 200 ml 4.6% w/v barium (group II) for fecal tagging. Excluding five patients in group I and one patient in group II that left the study, ten patients in group I and 14 patients in group II were finally included in the analysis. Two experienced readers evaluated the CTC images in consensus regarding the degree of tagging of stool pieces 6 mm or larger. Stool pieces were confirmed with the use of standardized CTC criteria or the absence of matched lesions as seen on colonoscopy. The rates of complete fecal tagging were analyzed on a per-lesion and a per-segment basis and were compared between the patients in the two groups. Results Per-lesion rates of complete fecal tagging were 52% (22 of 42; 95% CI, 37.7-66.6%) in group I and 78% (28 of 36; 95% CI, 61.7-88.5%) in group II. The difference between the two groups did not reach statistical significance (p = 0.285). The per-segment rates of complete tagging were 33% (6 of 18; 95% CI, 16.1%-56.4%) in group I and 60% (9 of 15; 95% CI, 35.7%-80.3%) in group II; again, the difference between the two groups did not reach statistical significance (p = 0.171). Conclusion Barium-based fecal tagging using both the 40% w/v and the 4.6% w/v barium suspensions showed moderate tagging efficacy. The preliminary comparison did not demonstrate a statistically significant difference in the tagging efficacy between the use of the two tagging agents, despite the tendency toward better tagging with the use of the 4.6% w/v barium

  7. A Preliminary Study of the Effect of Mobile-Based Education on Dental Students' Learning in Practical Course of Oral Pathology

    Directory of Open Access Journals (Sweden)

    mostafa babazadeh-kamangar

    2017-06-01

    Full Text Available Background and Objective: Mobile has provided a valuable teaching/learning opportunity for professors and students. Mobile electronic books are one of the educational resources that there is no defined plan for their usage at universities of medical sciences in Iran. This research aimed to evaluate mobile-based education for practical course of oral pathology. Materials and Methods: Oral pathology course was provided in the form of PowerPoint files and images and office suite was used to run these files. 30 general dentistry students in their sixth semester were divided into two equal groups. At first stage, a group of students were taught traditionally and another group through their mobile phones. Then, an examination was conducted to evaluate the traditional teaching (classroom and m-learning (mobile learning in these two groups. At second stage, the two groups were replaced but the contents didn’t change. Afterwards, a re-evaluation of traditional teaching and m-learning was done. In the end, the effects of these two methods of teaching on students’ learning were compared using statistical methods. Results: Results showed that mobile-based teaching significantly affected students’ final scores (P<0.05 and mean scores of the two groups in mobile-based teaching were significantly higher than mean scores of the two groups in traditional teaching. Conclusion: Mobile-based teaching can be used as a teaching aid in traditional classroom educations.

  8. Briefing package for the Yucca Flat pre-emptive review, including overview, UZ model, SZ volcanics model and summary and conclusions sections

    Energy Technology Data Exchange (ETDEWEB)

    Kwicklis, Edward Michael [Los Alamos National Laboratory; Keating, Elizabeth H [Los Alamos National Laboratory

    2010-12-02

    Much progress has been made in the last several years in modeling radionuclide transport from tests conducted both in the unsaturated zone and saturated volcanic rocks of Yucca Flat, Nevada. The presentations to the DOE NNSA pre-emptive review panel contained herein document the progress to date, and discuss preliminary conclusions regarding the present and future extents of contamination resulting from past nuclear tests. The presentations also discuss possible strategies for addressing uncertainty in the model results.

  9. Criteria for safety-related nuclear plant operator actions: a preliminary assessment of available data

    International Nuclear Information System (INIS)

    Haas, P.M.; Bott, T.F.

    1980-01-01

    In the US, an effort has been underway for a number of years to develop a design standard to define when required manual operator action can be accepted as part of a nuclear plant design basis. Insufficient data are available to provide quantitative guidelines for the standard. To provide the necessary data base to support such standards and the necessary quantitative assessment of operator reliability, the US Nuclear Regulatory Commission is sponsoring a study at Oak National Laboratory to develop the data base. A preliminary assessment completed in April, 1979 concluded that sufficient data from US operating experience did not exist to provide an adequate data base. A program of research using full-scope nuclear plant simulators and results that are correlated to field data was suggested. That program was recently initiated. The approach, results and conclusions of the preliminary assessment are reviewed and the planned research program of simulator studies is summarised. (author)

  10. Space Elevators Preliminary Architectural View

    Science.gov (United States)

    Pullum, L.; Swan, P. A.

    Space Systems Architecture has been expanded into a process by the US Department of Defense for their large scale systems of systems development programs. This paper uses the steps in the process to establishes a framework for Space Elevator systems to be developed and provides a methodology to manage complexity. This new approach to developing a family of systems is based upon three architectural views: Operational View OV), Systems View (SV), and Technical Standards View (TV). The top level view of the process establishes the stages for the development of the first Space Elevator and is called Architectural View - 1, Overview and Summary. This paper will show the guidelines and steps of the process while focusing upon components of the Space Elevator Preliminary Architecture View. This Preliminary Architecture View is presented as a draft starting point for the Space Elevator Project.

  11. Definition of sampling units begets conclusions in ecology: the case of habitats for plant communities.

    Science.gov (United States)

    Mörsdorf, Martin A; Ravolainen, Virve T; Støvern, Leif Einar; Yoccoz, Nigel G; Jónsdóttir, Ingibjörg Svala; Bråthen, Kari Anne

    2015-01-01

    In ecology, expert knowledge on habitat characteristics is often used to define sampling units such as study sites. Ecologists are especially prone to such approaches when prior sampling frames are not accessible. Here we ask to what extent can different approaches to the definition of sampling units influence the conclusions that are drawn from an ecological study? We do this by comparing a formal versus a subjective definition of sampling units within a study design which is based on well-articulated objectives and proper methodology. Both approaches are applied to tundra plant communities in mesic and snowbed habitats. For the formal approach, sampling units were first defined for each habitat in concave terrain of suitable slope using GIS. In the field, these units were only accepted as the targeted habitats if additional criteria for vegetation cover were fulfilled. For the subjective approach, sampling units were defined visually in the field, based on typical plant communities of mesic and snowbed habitats. For each approach, we collected information about plant community characteristics within a total of 11 mesic and seven snowbed units distributed between two herding districts of contrasting reindeer density. Results from the two approaches differed significantly in several plant community characteristics in both mesic and snowbed habitats. Furthermore, differences between the two approaches were not consistent because their magnitude and direction differed both between the two habitats and the two reindeer herding districts. Consequently, we could draw different conclusions on how plant diversity and relative abundance of functional groups are differentiated between the two habitats depending on the approach used. We therefore challenge ecologists to formalize the expert knowledge applied to define sampling units through a set of well-articulated rules, rather than applying it subjectively. We see this as instrumental for progress in ecology as only rules

  12. Definition of sampling units begets conclusions in ecology: the case of habitats for plant communities

    Directory of Open Access Journals (Sweden)

    Martin A. Mörsdorf

    2015-03-01

    Full Text Available In ecology, expert knowledge on habitat characteristics is often used to define sampling units such as study sites. Ecologists are especially prone to such approaches when prior sampling frames are not accessible. Here we ask to what extent can different approaches to the definition of sampling units influence the conclusions that are drawn from an ecological study? We do this by comparing a formal versus a subjective definition of sampling units within a study design which is based on well-articulated objectives and proper methodology. Both approaches are applied to tundra plant communities in mesic and snowbed habitats. For the formal approach, sampling units were first defined for each habitat in concave terrain of suitable slope using GIS. In the field, these units were only accepted as the targeted habitats if additional criteria for vegetation cover were fulfilled. For the subjective approach, sampling units were defined visually in the field, based on typical plant communities of mesic and snowbed habitats. For each approach, we collected information about plant community characteristics within a total of 11 mesic and seven snowbed units distributed between two herding districts of contrasting reindeer density. Results from the two approaches differed significantly in several plant community characteristics in both mesic and snowbed habitats. Furthermore, differences between the two approaches were not consistent because their magnitude and direction differed both between the two habitats and the two reindeer herding districts. Consequently, we could draw different conclusions on how plant diversity and relative abundance of functional groups are differentiated between the two habitats depending on the approach used. We therefore challenge ecologists to formalize the expert knowledge applied to define sampling units through a set of well-articulated rules, rather than applying it subjectively. We see this as instrumental for progress in

  13. The consultation and relational empathy (CARE) measure: development and preliminary validation and reliability of an empathy-based consultation process measure.

    Science.gov (United States)

    Mercer, Stewart W; Maxwell, Margaret; Heaney, David; Watt, Graham Cm

    2004-12-01

    Empathy is a key aspect of the clinical encounter but there is a lack of patient-assessed measures suitable for general clinical settings. Our aim was to develop a consultation process measure based on a broad definition of empathy, which is meaningful to patients irrespective of their socio-economic background. Qualitative and quantitative approaches were used to develop and validate the new measure, which we have called the consultation and relational empathy (CARE) measure. Concurrent validity was assessed by correlational analysis against other validated measures in a series of three pilot studies in general practice (in areas of high or low socio-economic deprivation). Face and content validity was investigated by 43 interviews with patients from both types of areas, and by feedback from GPs and expert researchers in the field. The initial version of the new measure (pilot 1; high deprivation practice) correlated strongly (r = 0.85) with the Reynolds empathy measure (RES) and the Barrett-Lennard empathy subscale (BLESS) (r = 0.63), but had a highly skewed distribution (skew -1.879, kurtosis 3.563). Statistical analysis, and feedback from the 20 patients interviewed, the GPs and the expert researchers, led to a number of modifications. The revised, second version of the CARE measure, tested in an area of low deprivation (pilot 2) also correlated strongly with the established empathy measures (r = 0.84 versus RES and r = 0.77 versus BLESS) but had a less skewed distribution (skew -0.634, kurtosis -0.067). Internal reliability of the revised version was high (Cronbach's alpha 0.92). Patient feedback at interview (n = 13) led to only minor modification. The final version of the CARE measure, tested in pilot 3 (high deprivation practice) confirmed the validation with the other empathy measures (r = 0.85 versus RES and r = 0.84 versus BLESS) and the face validity (feedback from 10 patients). These preliminary results support the validity and reliability of the CARE

  14. iPad-based primary 2D reading of CT angiography examinations of patients with suspected acute gastrointestinal bleeding: preliminary experience.

    Science.gov (United States)

    Faggioni, L; Neri, E; Bargellini, I; Scalise, P; Calcagni, F; Mantarro, A; D'Ippolito, G; Bartolozzi, C

    2015-03-01

    To evaluate the effectiveness of the iPad (Apple Inc., Cupertino, CA) for two-dimensional (2D) reading of CT angiography (CTA) studies performed for suspected acute non-variceal gastrointestinal bleeding. 24 CTA examinations of patients with suspected acute gastrointestinal bleeding confirmed (19/24, 79.2%) or ruled out (5/24, 20.8%) by digital subtraction angiography (DSA) were retrospectively reviewed by three independent readers on a commercial picture archiving communication system (PACS) workstation and on an iPad with Retina Display® 64 GB (Apple Inc.). The time needed to complete reading of every CTA examination was recorded, as well as the rate of detection of arterial bleeding and identification of suspected bleeding arteries on both devices. Overall, the area under the receiver operating characteristic curve, sensitivity, specificity, positive- and negative-predictive values for bleeding detection were not significantly different while using the iPad and workstation (0.774 vs 0.847, 0.947 vs 0.895, 0.6 vs 0.8, 0.9 vs 0.944 and 0.750 vs 0.667, respectively; p > 0.05). In DSA-positive cases, the iPad and workstation allowed correct identification of the bleeding source in 17/19 cases (89.5%) and 15/19 cases (78.9%), respectively (p > 0.05). Finally, the time needed to complete reading of every CTA study was significantly shorter using the iPad (169 ± 74 vs 222 ± 70 s, respectively; p < 0.01). Compared with a conventional PACS workstation, iPad-based preliminary 2D reading of CTA studies has comparable diagnostic accuracy for detection of acute gastrointestinal bleeding and can be significantly faster. The iPad could be used by on-call interventional radiologists for immediate decision on percutaneous embolization in patients with suspected acute gastrointestinal bleeding.

  15. Comparing effects in regular practice of e-communication and Web-based self-management support among breast cancer patients: preliminary results from a randomized controlled trial.

    Science.gov (United States)

    Børøsund, Elin; Cvancarova, Milada; Moore, Shirley M; Ekstedt, Mirjam; Ruland, Cornelia M

    2014-12-18

    While Web-based interventions have been shown to assist a wide range of patients successfully in managing their illness, few studies have examined the relative contribution of different Web-based components to improve outcomes. Further efficacy trials are needed to test the effects of Web support when offered as a part of routine care. Our aim was to compare in regular care the effects of (1) an Internet-based patient provider communication service (IPPC), (2) WebChoice, a Web-based illness management system for breast cancer patients (IPPC included), and (3) usual care on symptom distress, anxiety, depression, (primary outcomes), and self-efficacy (secondary outcome). This study reports preliminary findings from 6 months' follow-up data in a 12-month trial. We recruited 167 patients recently diagnosed with breast cancer and undergoing treatment from three Norwegian hospitals. The nurse-administered IPPC allowed patients to send secure e-messages to and receive e-messages from health care personnel at the hospital where they were treated. In addition to the IPPC, WebChoice contains components for symptom monitoring, tailored information and self-management support, a diary, and communication with other patients. A total of 20 care providers (11 nurses, 6 physicians, and 3 social workers) were trained to answer questions from patients. Outcomes were measured with questionnaires at study entry and at study months 2, 4, and 6. Linear mixed models for repeated measures were fitted to compare effects on outcomes over time. Patients were randomly assigned to the WebChoice group (n=64), the IPPC group (n=45), or the usual care group (n=58). Response rates to questionnaires were 73.7% (123/167) at 2 months, 65.9 (110/167) at 4 months, and 62.3% (104/167) at 6 months. Attrition was similar in all study groups. Among those with access to WebChoice, 64% (41/64) logged on more than once and 39% (25/64) sent e-messages to care providers. In the IPPC group, 40% (18/45) sent e

  16. Status of maintenance in the US nuclear power industry 1985. Volume 1. Findings and conclusions

    International Nuclear Information System (INIS)

    1986-06-01

    This report presents the findings, conclusions and recommendations derived from activities performed under Phase I of the NRC Maintenance and Surveillance Program (MSP). Findings are based on trends and patterns derived from operational data compiled by the NRC for the period 1980 through 1985, site surveys conducted at eight plants, and questionnaires administered to NRC Resident Inspectors to characterize nuclear power plant maintenance programs and practices. These activities have shown that plant maintenance programs and practices are highly variable from plant-to-plant and are currently undergoing major changes. While measured plant performance has improved overall since 1980, the maintenance-related contribution to reportable events and challenges to safety systems remains high and is increasing by some measures. The findings of Phase I of the MSP confirmed a number of problems in nuclear power plant maintenance which warrant further NRC and industry attention

  17. Gasification of waste. Summary and conclusions of twenty-five years of development

    Energy Technology Data Exchange (ETDEWEB)

    Rensfelt, Erik [TPS Termiska Processer AB, Nykoeping (Sweden); Oestman, Anders [Kemiinformation AB, Stockholm (Sweden)

    2000-04-01

    An overview of nearly thirty years development of waste gasification and pyrolysis technology is given, and some major general conclusions are drawn. The aim has been to give new developers an overview of earlier major attempts to treat MSW/RDF with thermochemical processes, gasification or pyrolysis. Research work in general is not covered, only R and D efforts that have led to substantial testing in pilot scale or demonstration. For further details, especially related to ongoing R and D, readers are referred to other recent reviews. The authors' view is that gasification of RDF with appropriate gas cleaning can play an important role in the future, for environmentally acceptable and efficient energy production. A prerequisite is that some of the major mistakes can be avoided, such as: (1) too rapid scale-up without experimental base, (2) unsuitable pretreatment of MSW to RDF and poor integration with material recycling, and (3) too limited gas/flue gas cleaning.

  18. Analysing and exemplifying forensic conclusion criteria in terms of Bayesian decision theory.

    Science.gov (United States)

    Biedermann, A; Bozza, S; Taroni, F

    2018-03-01

    There is ongoing discussion in forensic science and the law about the nature of the conclusions reached based on scientific evidence, and on how such conclusions - and conclusion criteria - may be justified by rational argument. Examples, among others, are encountered in fields such as fingermarks (e.g., 'this fingermark comes from Mr. A's left thumb'), handwriting examinations (e.g., 'the questioned signature is that of Mr. A'), kinship analyses (e.g., 'Mr. A is the father of child C') or anthropology (e.g., 'these are human remains'). Considerable developments using formal methods of reasoning based on, for example (Bayesian) decision theory, are available in literature, but currently such reference principles are not explicitly used in operational forensic reporting and ensuing decision-making. Moreover, applied examples, illustrating the principles, are scarce. A potential consequence of this in practical proceedings, and hence a cause of concern, is that underlying ingredients of decision criteria (such as losses quantifying the undesirability of adverse decision consequences), are not properly dealt with. There is merit, thus, in pursuing the study and discussion of practical examples, demonstrating that formal decision-theoretic principles are not merely conceptual considerations. Actually, these principles can be shown to underpin practical decision-making procedures and existing legal decision criteria, though often not explicitly apparent as such. In this paper, we will present such examples and discuss their properties from a Bayesian decision-theoretic perspective. We will argue that these are essential concepts for an informed discourse on decision-making across forensic disciplines and the development of a coherent view on this topic. We will also emphasize that these principles are of normative nature in the sense that they provide standards against which actual judgment and decision-making may be compared. Most importantly, these standards are

  19. The effects of short term intravenous infusion of a soybean based lipid emulsion on some blood constituents in sheep: A preliminary study

    Directory of Open Access Journals (Sweden)

    Hamid Akbari

    2014-04-01

    Full Text Available To evaluate the effect of intravenous infusion of a soybean based lipid emulsion (Lipovenoes 10% on some blood constituents in sheep, a replicated 2 × 2 Latin square design experiment was conducted in four clinically healthy ewes. Lipid emulsion (LE group or normal saline (NS group was infused intravenously at a rate of 0.025 mL kg-1 per min for 6 hr and the concentrations of blood triglyceride, glucose, insulin, calcium, magnesium, phosphorous, sodium and potassium were measured before (baseline and then at timepoints 2, 4, 6, 12 and 24 hr after infusion. Compared to the baseline values and/or NS infusion, LE infusion resulted in a significant increase in the concentrations of triglyceride (p 0.05. In conclusion, intravenous infusion of Lipovenoes temporarily influenced some blood constituents. Increased triglyceride concentrations were associated with an increase in HOMA-IR values indicating a state of insulin resistance. No remarkable adverse effect was observed following LE infusion and lipid based emulsions can be safely used in ruminants not suffering from extensive lipid mobilization.

  20. Flat panel detector-based cone beam computed tomography with a circle-plus-two-arcs data acquisition orbit: Preliminary phantom study

    International Nuclear Information System (INIS)

    Ning Ruola; Tang Xiangyang; Conover, David; Yu Rongfeng

    2003-01-01

    Cone beam computed tomography (CBCT) has been investigated in the past two decades due to its potential advantages over a fan beam CT. These advantages include (a) great improvement in data acquisition efficiency, spatial resolution, and spatial resolution uniformity, (b) substantially better utilization of x-ray photons generated by the x-ray tube compared to a fan beam CT, and (c) significant advancement in clinical three-dimensional (3D) CT applications. However, most studies of CBCT in the past are focused on cone beam data acquisition theories and reconstruction algorithms. The recent development of x-ray flat panel detectors (FPD) has made CBCT imaging feasible and practical. This paper reports a newly built flat panel detector-based CBCT prototype scanner and presents the results of the preliminary evaluation of the prototype through a phantom study. The prototype consisted of an x-ray tube, a flat panel detector, a GE 8800 CT gantry, a patient table and a computer system. The prototype was constructed by modifying a GE 8800 CT gantry such that both a single-circle cone beam acquisition orbit and a circle-plus-two-arcs orbit can be achieved. With a circle-plus-two-arcs orbit, a complete set of cone beam projection data can be obtained, consisting of a set of circle projections and a set of arc projections. Using the prototype scanner, the set of circle projections were acquired by rotating the x-ray tube and the FPD together on the gantry, and the set of arc projections were obtained by tilting the gantry while the x-ray tube and detector were at the 12 and 6 o'clock positions, respectively. A filtered backprojection exact cone beam reconstruction algorithm based on a circle-plus-two-arcs orbit was used for cone beam reconstruction from both the circle and arc projections. The system was first characterized in terms of the linearity and dynamic range of the detector. Then the uniformity, spatial resolution and low contrast resolution were assessed using

  1. Move Analysis of the Conclusion Sections of Research Papers in Persian and English

    Science.gov (United States)

    Zamani, Gerannaz; Ebadi, Saman

    2016-01-01

    The structure of the conclusion sections in Research Papers (RPs) is of significance in academic writing. The conclusion section in spite of providing an outline of the article, states other essential components, such as recommendations, implications and statements of possible lines of future research. This paper analyses the conclusion parts of…

  2. No Conclusive Evidence for Transits of Proxima b in MOST Photometry

    Energy Technology Data Exchange (ETDEWEB)

    Kipping, David M.; Chen, Jingjing; Sandford, Emily [Department of Astronomy, Columbia University, 550 W. 120th Street, New York, NY 10027 (United States); Cameron, Chris [Department of Mathematics, Physics and Geology, Cape Breton University, 1250 Grand Lake Road, Sydney, NS B1P 6L2 (Canada); Hartman, Joel D.; Bakos, Gáspár Á.; Penev, Kaloyan; Csubry, Zoltan [Department of Astrophysical Sciences, 4 Ivy Lane, Princeton, NJ 08544 (United States); Davenport, James R. A. [Department of Physics and Astronomy, Western Washington University, 516 High Street, Bellingham, WA 98225 (United States); Matthews, Jaymie M. [Department of Physics and Astronomy, University of British Columbia, 6224 Agricultural Road, Vancouver, BC V6T 1Z1 (Canada); Sasselov, Dimitar [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Rowe, Jason [Observatoire Astronomque du Mont Mégantic, Départment de Physique, Université de Montréal C. P. 6128, Succursale, Centre-Ville, Montréal, QC H3C 3J7 (Canada); Siverd, Robert J. [Las Cumbres Observatory Global Telescope Network, 6740 Cortona Drive, Suite 102, Santa Barbara, CA 93117 (United States); Jordán, Andrés [Instituto de Astrofísica, Universidad Católica de Chile, Av. Vicuña Mackenna 4860, 7820436 Macul, Santiago (Chile); Bayliss, Daniel [Observatoire Astronomique de Universite de Genéve, 51 ch. des Maillettes, 1290 Versoix (Switzerland); Henning, Thomas; Mancini, Luigi [Max Plank Institute for Astronomy, Königstuhl 17, D-69117 Heidelberg (Germany); and others

    2017-03-01

    The analysis of Proxima Centauri’s radial velocities recently led Anglada-Escudé et al. to claim the presence of a low-mass planet orbiting the Sun’s nearest star once every 11.2 days. Although the a priori probability that Proxima b transits its parent star is just 1.5%, the potential impact of such a discovery would be considerable. Independent of recent radial velocity efforts, we observed Proxima Centauri for 12.5 days in 2014 and 31 days in 2015 with the Microwave and Oscillations of Stars space telescope. We report here that we cannot make a compelling case that Proxima b transits in our precise photometric time series. Imposing an informative prior on the period and phase, we do detect a candidate signal with the expected depth. However, perturbing the phase prior across 100 evenly spaced intervals reveals one strong false positive and one weaker instance. We estimate a false-positive rate of at least a few percent and a much higher false-negative rate of 20%–40%, likely caused by the very high flare rate of Proxima Centauri. Comparing our candidate signal to HATSouth ground-based photometry reveals that the signal is somewhat, but not conclusively, disfavored (1 σ –2 σ ), leading us to argue that the signal is most likely spurious. We expect that infrared photometric follow-up could more conclusively test the existence of this candidate signal, owing to the suppression of flare activity and the impressive infrared brightness of the parent star.

  3. The 2015 Dietary Guidelines Advisory Committee Scientific Report: Development and Major Conclusions.

    Science.gov (United States)

    Millen, Barbara E; Abrams, Steve; Adams-Campbell, Lucile; Anderson, Cheryl Am; Brenna, J Thomas; Campbell, Wayne W; Clinton, Steven; Hu, Frank; Nelson, Miriam; Neuhouser, Marian L; Perez-Escamilla, Rafael; Siega-Riz, Anna Maria; Story, Mary; Lichtenstein, Alice H

    2016-05-01

    The Dietary Guidelines for Americans (DGA) is published every 5 y jointly by the Department of Health and Human Services (HHS) and the USDA and provides a framework for US-based food and nutrition programs, health promotion and disease prevention initiatives, and research priorities. Summarized in this report are the methods, major conclusions, and recommendations of the Scientific Report of the 2015 US Dietary Guidelines Advisory Committee (DGAC). Early in the process, the DGAC developed a conceptual model and formulated questions to examine nutritional risk and determinants and impact of dietary patterns in relation to numerous health outcomes among individuals aged ≥2 y. As detailed in the report, an expansive, transparent, and comprehensive process was used to address each question, with multiple opportunities for public input included. Consensus was reached on all DGAC's findings, including each conclusion and recommendation, and the entire report. When research questions were answered by original systematic literature reviews and/or with existing, high-quality expert reports, the quality and strength of the evidence was formally graded. The report was organized around the following 5 themes: 1) food and nutrient intakes and health: current status and trends; 2) dietary patterns, foods and nutrients, and health outcomes; 3) diet and physical activity behavior change; 4) food and physical activity environments; and 5) food sustainability and food safety. The following 3 cross-cutting topics were addressed: 1) sodium, 2) saturated fat, and 3) added sugars. Physical activity recommendations from recent expert reports were endorsed. The overall quality of the American diet was assessed to identify overconsumed and underconsumed nutrients of public health concern. Common food characteristics of healthy dietary patterns were determined. Features of effective interventions to change individual and population diet and physical activity behaviors in clinical, public

  4. Conclusiveness of the Cochrane reviews in gynaecological cancer: A systematic analysis.

    Science.gov (United States)

    Yin, Shande; Chuai, Yunhai; Wang, Aiming; Zhang, Lanmei

    2015-06-01

    To assess the conclusiveness of Cochrane reviews in the field of gynaecological cancer. The Cochrane Library was searched for reviews regarding gynaecological cancer published between 1 January 2000 and 1 November 2014. Data were extracted from each paper and the conclusiveness of each review was assessed. The study included 66 reviews, 41 (62.1%) of which were conclusive. Of these, 58 included randomized controlled trials (RCTs), 37 (63.8%) of which were conclusive. Conclusive reviews of RCTs included significantly more patients than inconclusive reviews, but there was no difference in the number of included studies. Of the eight reviews of nonrandomized studies, four (50.0%) were conclusive. The majority of reviews recognized the need for additional studies. In the field of gynaecological cancer, reviews are more likely to be conclusive when they include RCTs, as well as large numbers of patients. © The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  5. OECD/CSNI Workshop on In-Vessel Core Debris Retention and Coolability - Summary and Conclusions

    International Nuclear Information System (INIS)

    Behbahani, Ali-Reza; Drozd, Andrzej; Kim, Sang-Baik; Micaelli, Jean-Claude; Okkonen, Timo; Sugimoto, Jun; Trambauer, Klaus; Tuomisto, Harri

    1999-01-01

    In the spring of 1994 an OECD Workshop on Large Pool Heat transfer was held in Grenoble. The scope of this workshop was the investigation of (1) molten pool heat transfer, (2) heat transfer to the surrounding water, and (3) the feasibility of in-vessel core debris cooling through external cooling of the vessel. Since this time, experimental test series have been completed (e.g., COPO, ULPU, CORVIS) and new experimental programs (e.g., BALI, SONATA, RASPLAV, debris and gap heat transfer) have been established to consolidate and expand the data base for further model development and to improve the understanding of in-vessel debris retention and coolability in a nuclear power plant. Discussions within the CSNI's PWG-2 and the Task Group on Degraded Core Cooling (TG-DCC) have led to the conclusion that the time was ripe for organizing a new international Workshop with the objectives: - to review the results of experimental research that has been conducted in this area; - to exchange information on the results of member countries experiments and model development on in-vessel core debris retention and coolability; - to discuss areas where additional experimental research is needed in order to provide an adequate data base for analytical model development for core debris retention and coolability. The scope of this workshop was limited to the phenomena connected to in-vessel core debris retention and coolability and did not include steam explosion and fission product issues. The workshop was structured into the following sessions: Key note papers; Experiments and model development; Debris bed heat transfer; Corium properties, molten pool convection and crust formation; Gap formation and gap cooling; Creep behaviour of reactor pressure vessel lower head; Ex-vessel boiling and critical heat flux phenomena; Scaling to reactor severe accident conditions and reactor applications. Compared to the previous workshop held in Grenoble in 1994, large progress has been made in the

  6. Why do different criteria for 'cure' yield different conclusions in comparing two treatments for bacterial vaginosis?

    Science.gov (United States)

    Thomas, Katherine K; Sanchez, Sixto; Garcia, Patricia J; Holmes, King K

    2005-09-01

    The objective of this study was to determine why different criteria for response to treatment of bacterial vaginosis (BV) led to markedly different conclusions about treatment efficacy in a randomized trial comparing metronidazole gel versus metronidazole/nystatin ovules. We compared the impact of two treatment regimens on individual components of Amsel and Nugent criteria at follow-up visits 14, 42, and 104 days after initiating treatment. Compared with gel, ovules more effectively eliminated amines, clue cells, and Gardnerella, Prevotella, or Mobiluncus morphotypes from vaginal fluid, thus achieving cure based on "usual" criteria (absence of BV by Amsel or Nugent criteria), but did not more effectively restore Lactobacillus morphotypes or lower vaginal pH, thus not meeting Federal Drug Administration (FDA) criteria for cure. Because early vaginal recolonization by lactobacilli was poor after both gel and ovules, FDA draft criteria for cure missed marked differences in treatment efficacies against Gardnerella, clue cells, and amines. Cure defined more "usually" may give more useful information.

  7. Results and Conclusions from the NASA Isokinetic Total Water Content Probe 2009 IRT Test

    Science.gov (United States)

    Reehorst, Andrew; Brinker, David

    2010-01-01

    The NASA Glenn Research Center has developed and tested a Total Water Content Isokinetic Sampling Probe. Since, by its nature, it is not sensitive to cloud water particle phase nor size, it is particularly attractive to support super-cooled large droplet and high ice water content aircraft icing studies. The instrument comprises the Sampling Probe, Sample Flow Control, and Water Vapor Measurement subsystems. Results and conclusions are presented from probe tests in the NASA Glenn Icing Research Tunnel (IRT) during January and February 2009. The use of reference probe heat and the control of air pressure in the water vapor measurement subsystem are discussed. Several run-time error sources were found to produce identifiable signatures that are presented and discussed. Some of the differences between measured Isokinetic Total Water Content Probe and IRT calibration seems to be caused by tunnel humidification and moisture/ice crystal blow around. Droplet size, airspeed, and liquid water content effects also appear to be present in the IRT calibration. Based upon test results, the authors provide recommendations for future Isokinetic Total Water Content Probe development.

  8. Conclusions from working group 2 - the analyses of the WIPP-2 experiments

    International Nuclear Information System (INIS)

    Jackson, C.P.

    1995-01-01

    The INTRAVAL WIPP-2 test case is based on data from site investigations carried out at the Waste Isolation Pilot Plant (WIPP) in New Mexico, USA. The site has been chosen as a potential location for a radioactive waste repository. Extensive investigations have been carried out, focused mainly on groundwater flow and transport in the Culebra Dolomite, the main pathway for transport of radionuclides off the site by groundwater in the case of an accidental borehole intrusion into the repository. Five teams studied the test case. Two teams addressed issues involved in the treatment of heterogeneity. Stochastic models and a Monte Carlo approach were used. One team quantified the increased uncertainty resulting from fewer data and explored the issues involved in validation of stochastic models. A second team developed a new method for conditioning stochastic models on head data. Two other teams examined issues relating to the choice of conceptual models. Two-dimensional vertical cross-section models were used to explore the importance of vertical flow. The fifth team advocate the use of a variety of models to highlight the most important processes and parameters. Conclusions from each team experiment are analysed. (J.S.). 4 refs., 11 figs

  9. Preliminary seismic design of dynamically coupled structural systems

    International Nuclear Information System (INIS)

    Pal, N.; Dalcher, A.W.; Gluck, R.

    1977-01-01

    In this paper, the analysis criteria for coupling and decoupling, which are most commonly used in nuclear design practice, are briefly reviewed and a procedure outlined and demonstrated with examples. Next, a criterion judged to be practical for preliminary seismic design purposes is defined. Subsequently, a technique compatible with this criterion is suggested. A few examples are presented to test the proposed procedure for preliminary seismic design purposes. Limitations of the procedure are also discussed and finally, the more important conclusions are summarized

  10. Relationship between funding source and conclusion among nutrition-related scientific articles.

    Science.gov (United States)

    Lesser, Lenard I; Ebbeling, Cara B; Goozner, Merrill; Wypij, David; Ludwig, David S

    2007-01-01

    Industrial support of biomedical research may bias scientific conclusions, as demonstrated by recent analyses of pharmaceutical studies. However, this issue has not been systematically examined in the area of nutrition research. The purpose of this study is to characterize financial sponsorship of scientific articles addressing the health effects of three commonly consumed beverages, and to determine how sponsorship affects published conclusions. Medline searches of worldwide literature were used to identify three article types (interventional studies, observational studies, and scientific reviews) about soft drinks, juice, and milk published between 1 January, 1999 and 31 December, 2003. Financial sponsorship and article conclusions were classified by independent groups of coinvestigators. The relationship between sponsorship and conclusions was explored by exact tests and regression analyses, controlling for covariates. 206 articles were included in the study, of which 111 declared financial sponsorship. Of these, 22% had all industry funding, 47% had no industry funding, and 32% had mixed funding. Funding source was significantly related to conclusions when considering all article types (p = 0.037). For interventional studies, the proportion with unfavorable conclusions was 0% for all industry funding versus 37% for no industry funding (p = 0.009). The odds ratio of a favorable versus unfavorable conclusion was 7.61 (95% confidence interval 1.27 to 45.73), comparing articles with all industry funding to no industry funding. Industry funding of nutrition-related scientific articles may bias conclusions in favor of sponsors' products, with potentially significant implications for public health.

  11. Conclusiveness of fine needle aspiration in 2419 histologically confirmed benign and malignant breast lesions

    NARCIS (Netherlands)

    Kooistra, B.; Wauters, C.; Wobbes, T.; Strobbe, L.

    2011-01-01

    We aimed to retrospectively assess (1) the conclusiveness of breast fine needle aspiration (FNA) in a histologically confirmed population and (2) the clinical and radiologic determinants of a conclusive diagnosis. Aspirates were diagnosed as inadequate, benign, atypical, suspicious or malignant. We

  12. 20 CFR 410.471 - Conclusion by physician regarding miner's disability or death.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Conclusion by physician regarding miner's disability or death. 410.471 Section 410.471 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Total Disability or Death Due to Pneumoconiosis § 410.471 Conclusion...

  13. Diffusion versus linear ballistic accumulation: different models but the same conclusions about psychological processes?

    NARCIS (Netherlands)

    Donkin, C.; Brown, S.; Heathcote, A.; Wagenmakers, E.-J.

    2011-01-01

    Quantitative models for response time and accuracy are increasingly used as tools to draw conclusions about psychological processes. Here we investigate the extent to which these substantive conclusions depend on whether researchers use the Ratcliff diffusion model or the Linear Ballistic

  14. Medium-dose-rate brachytherapy of cancer of the cervix: preliminary results of a prospectively designed schedule based on the linear-quadratic model

    International Nuclear Information System (INIS)

    Leborgne, Felix; Fowler, Jack F.; Leborgne, Jose H.; Zubizarreta, Eduardo; Curochquin, Rene

    1999-01-01

    Purpose: To compare results and complications of our previous low-dose-rate (LDR) brachytherapy schedule for early-stage cancer of the cervix, with a prospectively designed medium-dose-rate (MDR) schedule, based on the linear-quadratic model (LQ). Methods and Materials: A combination of brachytherapy, external beam pelvic and parametrial irradiation was used in 102 consecutive Stage Ib-IIb LDR treated patients (1986-1990) and 42 equally staged MDR treated patients (1994-1996). The planned MDR schedule consisted of three insertions on three treatment days with six 8-Gy brachytherapy fractions to Point A, two on each treatment day with an interfraction interval of 6 hours, plus 18 Gy external whole pelvic dose, and followed by additional parametrial irradiation. The calculated biologically effective dose (BED) for tumor was 90 Gy 10 and for rectum below 125 Gy 3 . Results: In practice the MDR brachytherapy schedule achieved a tumor BED of 86 Gy 10 and a rectal BED of 101 Gy 3 . The latter was better than originally planned due to a reduction from 85% to 77% in the percentage of the mean dose to the rectum in relation to Point A. The mean overall treatment time was 10 days shorter for MDR in comparison with LDR. The 3-year actuarial central control for LDR and MDR was 97% and 98% (p = NS), respectively. The Grades 2 and 3 late complications (scale 0 to 3) were 1% and 2.4%, respectively for LDR (3-year) and MDR (2-year). Conclusions: LQ is a reliable tool for designing new schedules with altered fractionation and dose rates. The MDR schedule has proven to be an equivalent treatment schedule compared with LDR, with an additional advantage of having a shorter overall treatment time. The mean rectal BED Gy 3 was lower than expected

  15. Forensic scientists' conclusions: how readable are they for non-scientist report-users?

    Science.gov (United States)

    Howes, Loene M; Kirkbride, K Paul; Kelty, Sally F; Julian, Roberta; Kemp, Nenagh

    2013-09-10

    Scientists have an ethical responsibility to assist non-scientists to understand their findings and expert opinions before they are used as decision-aids within the criminal justice system. The communication of scientific expert opinion to non-scientist audiences (e.g., police, lawyers, and judges) through expert reports is an important but under-researched issue. Readability statistics were used to assess 111 conclusions from a proficiency test in forensic glass analysis. The conclusions were written using an average of 23 words per sentence, and approximately half of the conclusions were expressed using the active voice. At an average Flesch-Kincaid Grade level of university undergraduate (Grade 13), and Flesch Reading Ease score of difficult (42), the conclusions were written at a level suitable for people with some tertiary education in science, suggesting that the intended non-scientist readers would find them difficult to read. To further analyse the readability of conclusions, descriptive features of text were used: text structure; sentence structure; vocabulary; elaboration; and coherence and unity. Descriptive analysis supported the finding that texts were written at a level difficult for non-scientists to read. Specific aspects of conclusions that may pose difficulties for non-scientists were located. Suggestions are included to assist scientists to write conclusions with increased readability for non-scientist readers, while retaining scientific integrity. In the next stage of research, the readability of expert reports in their entirety is to be explored. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  16. Beads task vs. box task: The specificity of the jumping to conclusions bias.

    Science.gov (United States)

    Balzan, Ryan P; Ephraums, Rachel; Delfabbro, Paul; Andreou, Christina

    2017-09-01

    Previous research involving the probabilistic reasoning 'beads task' has consistently demonstrated a jumping-to-conclusions (JTC) bias, where individuals with delusions make decisions based on limited evidence. However, recent studies have suggested that miscomprehension may be confounding the beads task. The current study aimed to test the conventional beads task against a conceptually simpler probabilistic reasoning "box task" METHODS: One hundred non-clinical participants completed both the beads task and the box task, and the Peters et al. Delusions Inventory (PDI) to assess for delusion-proneness. The number of 'draws to decision' was assessed for both tasks. Additionally, the total amount of on-screen evidence was manipulated for the box task, and two new box task measures were assessed (i.e., 'proportion of evidence requested' and 'deviation from optimal solution'). Despite being conceptually similar, the two tasks did not correlate, and participants requested significantly less information on the beads task relative to the box task. High-delusion-prone participants did not demonstrate hastier decisions on either task; in fact, for box task, this group was observed to be significantly more conservative than low-delusion-prone group. Neither task was incentivized; results need replication with a clinical sample. Participants, and particularly those identified as high-delusion-prone, displayed a more conservative style of responding on the novel box task, relative to the beads task. The two tasks, whilst conceptually similar, appear to be tapping different cognitive processes. The implications of these results are discussed in relation to the JTC bias and the theoretical mechanisms thought to underlie it. Copyright © 2016 Elsevier Ltd. All rights reserved.

  17. Radioactive-waste ocean dumping will have negligible enviromental impact. Conclusion of draft assessment of NSB

    Energy Technology Data Exchange (ETDEWEB)

    1976-11-01

    This draft report is the result of extensive studies based on the best available information in the field of oceanography, marine radiobiology and health physics. On various basic considerations, assessment was undertaken, and the following conclusion was reached. The quantity of radioactivity to be dumped at one time is assumed to be 500 Ci in the case of test dumping, and 10/sup 5/ Ci/year in the case of full-scale dumping. The conditions required for the dumping sea area are that the bottom water flow and upwelling amount are limited, and that the sea bottom is flat. The horizontal dispersion coefficient of 10/sup 7/ cm/sup 2//sec and the vertical dispersion coefficient of 2 x 10/sup 2/ cm/sup 2//sec are assumed. It is assumed that the radionuclides in the disposed package would leached out as soon as it reaches the sea bottom, and would not show any physicochemical behavior. Typycal radionuclides are classified into 5 groups in terms of their half lives, and their estimated concentrations at 1 km depth are tabulated. The maximum level of individual dose and the magnitude of population dose were assessed on the fishermen working in the dumping sea area, and the adults, children and infants who were expected to receive higher dose on account of the larger intake of fish products than average. The dose level given with the dose assessment model and various panamentors under the dumping conditions is much lower than natural radiation and the permissible level recommended by ICRP.

  18. Conclusions of the presidency. European council of Barcelona, March 15 and 16 2002; Conclusions de la presidence. Conseil europeen de Barcelone 15 et 16 mars 2002

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    This document summarizes the conclusions of the European Council held in Barcelona (Spain) on March 15 and 16, 2002. Among the priority actions listed by the council figure the integration of energy, transportation and communication networks at the European scale. In particular, the council commits the Parliament and itself to start the final phase of opening of gas and electricity markets: free choice of a supplier, obligation of public utility, security of supplies, separation between transmission and distribution and between production and supply, non-discriminatory access of consumers and suppliers to networks with transparent tariffs, establishment of a regulatory agency in each member state, agreement for a tariffing system for the international electricity trades etc.. Concerning the sustainable development strategy of the European union, the council is pressing the member states for the completion of the national procedures of ratification of the Kyoto protocol. However, new measures need to be taken to develop technologies respectful for the environment, in particular in the domain of energy and transports. (J.S.)

  19. The Adaptation Gap Report - a Preliminary Assessment

    DEFF Research Database (Denmark)

    Alverson, Keith; Olhoff, Anne; Noble, Ian

    This first Adaptation Gap report provides an equally sobering assessment of the gap between adaptation needs and reality, based on preliminary thinking on how baselines, future goals or targets, and gaps between them might be defined for climate change adaptation. The report focuses on gaps...... in developing countries in three important areas: finance, technology and knowledge....

  20. Preliminary tests of the electrostatic plasma accelerator

    Science.gov (United States)

    Aston, G.; Acker, T.

    1990-01-01

    This report describes the results of a program to verify an electrostatic plasma acceleration concept and to identify those parameters most important in optimizing an Electrostatic Plasma Accelerator (EPA) thruster based upon this thrust mechanism. Preliminary performance measurements of thrust, specific impulse and efficiency were obtained using a unique plasma exhaust momentum probe. Reliable EPA thruster operation was achieved using one power supply.

  1. Hydrothermal Liquefaction Treatment Preliminary Hazard Analysis Report

    Energy Technology Data Exchange (ETDEWEB)

    Lowry, Peter P.; Wagner, Katie A.

    2015-08-31

    A preliminary hazard assessment was completed during February 2015 to evaluate the conceptual design of the modular hydrothermal liquefaction treatment system. The hazard assessment was performed in 2 stages. An initial assessment utilizing Hazard Identification and Preliminary Hazards Analysis (PHA) techniques identified areas with significant or unique hazards (process safety-related hazards) that fall outside of the normal operating envelope of PNNL and warranted additional analysis. The subsequent assessment was based on a qualitative What-If analysis. This analysis was augmented, as necessary, by additional quantitative analysis for scenarios involving a release of hazardous material or energy with the potential for affecting the public.

  2. LEAping to conclusions: A computational reanalysis of late embryogenesis abundant proteins and their possible roles

    Directory of Open Access Journals (Sweden)

    Wise Michael J

    2003-10-01

    Full Text Available Abstract Background The late embryogenesis abundant (LEA proteins cover a number of loosely related groups of proteins, originally found in plants but now being found in non-plant species. Their precise function is unknown, though considerable evidence suggests that LEA proteins are involved in desiccation resistance. Using a number of statistically-based bioinformatics tools the classification of a large set of LEA proteins, covering all Groups, is reexamined together with some previous findings. Searches based on peptide composition return proteins with similar composition to different LEA Groups; keyword clustering is then applied to reveal keywords and phrases suggestive of the Groups' properties. Results Previous research has suggested that glycine is characteristic of LEA proteins, but it is only highly over-represented in Groups 1 and 2, while alanine, thought characteristic of Group 2, is over-represented in Group 3, 4 and 6 but under-represented in Groups 1 and 2. However, for LEA Groups 1 2 and 3 it is shown that glutamine is very significantly over-represented, while cysteine, phenylalanine, isoleucine, leucine and tryptophan are significantly under-represented. There is also evidence that the Group 4 LEA proteins are more appropriately redistributed to Group 2 and Group 3. Similarly, Group 5 is better found among the Group 3 LEA proteins. Conclusions There is evidence that Group 2 and Group 3 LEA proteins, though distinct, might be related. This relationship is also evident in the overlapping sets of keywords for the two Groups, emphasising alpha-helical structure and, at a larger scale, filaments, all of which fits well with experimental evidence that proteins from both Groups are natively unstructured, but become structured under stress conditions. The keywords support localisation of LEA proteins both in the nucleus and associated with the cytoskeleton, and a mode of action similar to chaperones, perhaps the cold shock chaperones

  3. Summary of the workshop robustness of electrical systems - Conclusions and recommendations

    International Nuclear Information System (INIS)

    2015-01-01

    The workshop included an opening session, seven sessions with participant presentations followed by short discussions, and a facilitated discussion session. The contributions presented were devoted to discussions of national post-Fukushima regulatory programme developments, methods to determine allowable coping time for electric power recovery, electric power system simulation methods development and benchmarking efforts, analysis of component capability, and approaches to facilitate electric power system recovery from extended loss of AC power. The following conclusions and recommendations are made based on workshop presentations, discussions during particular sessions, and facilitated discussions: - Based upon the panel discussions at the end of the workshop, a majority of the participants suggested the need for continuing efforts after the ROBELSYS workshop and particularly the importance of launching a more permanent international working group on modeling tools and methods related to nuclear power plant electrical power system studies. The working group would be modelled on WGRISK. (It is recognized that creating such a permanent working group would require a multi-year commitment of CSNI and the participants). - It will be very beneficial to continue international information sharing of the following items, eventually leading to development of suitable international electrical standards: System and component requirements for addressing beyond design basis external events; Recommended practice for incorporating diversity in the onsite electrical power system; Recommended practice for relaxing electric power protection features used in emergency situations (assuring margin against spurious electrical shutdowns); Recommended practice for qualification requirements for existing systems and portable components used to cope with AC station blackout. - There is a need for further development and improvements in the analysis and simulation of the following

  4. Three Mile Island unit 2 vessel investigation project. Conclusions and significance

    International Nuclear Information System (INIS)

    Beckjord, E.S.

    1994-01-01

    At the conclusion of the TMI-2 Vessel Investigation Project, additional insights about the accident have been gained, specifically in the area of reactor vessel integrity and the conditions of the lower head of the reactor vessel. This paper discusses three topics: the evolving views about the TMI-2 accident scenario over time, the technical conclusions of the TMI-2 VIP (recovery of samples from the vessel lower head), and the broad significance of these findings (accident management). 4 refs

  5. Funding source, conflict of interest and positive conclusions in neuro-oncology clinical trials.

    Science.gov (United States)

    Moraes, Fabio Y; Mendez, Lucas C; Taunk, Neil K; Raman, Srinivas; Suh, John H; Souhami, Luis; Slotman, Ben; Weltman, Eduardo; Spratt, Daniel E; Berlin, Alejandro; Marta, Gustavo N

    2018-02-01

    We aimed to test any association between authors' conclusions and self-reported COI or funding sources in central nervous system (CNS) studies. A review was performed for CNS malignancy clinical trials published in the last 5 years. Two investigators independently classified study conclusions according to authors' endorsement of the experimental therapy. Statistical models were used to test for associations between positive conclusions and trials characteristics. From February 2010 to February 2015, 1256 articles were retrieved; 319 were considered eligible trials. Positive conclusions were reported in 56.8% of trials with industry-only, 55.6% with academia-only, 44.1% with academia and industry, 77.8% with none, and 76.4% with not described funding source (p = 0.011). Positive conclusions were reported in 60.4% of trials with unrelated COI, 60% with related COI, and 60% with no COI reported (p = 0.997). Factors that were significantly associated with the presence of positive conclusion included trials design (phase 1) [OR 11.64 (95 CI 4.66-29.09), p source [OR 2.45 (95 CI 1.22-5.22), p = 0.011]. In a multivariable regression model, all these factors remained significantly associated with trial's positive conclusion. Funding source and self-reported COI did not appear to influence the CNS trials conclusion. Funding source information and COI disclosure were under-reported in 14.1 and 17.2% of the CNS trials. Continued efforts are needed to increase rates of both COI and funding source reporting.

  6. Application of Artificial Neural Networks in the Heart Electrical Axis Position Conclusion Modeling

    Science.gov (United States)

    Bakanovskaya, L. N.

    2016-08-01

    The article touches upon building of a heart electrical axis position conclusion model using an artificial neural network. The input signals of the neural network are the values of deflections Q, R and S; and the output signal is the value of the heart electrical axis position. Training of the network is carried out by the error propagation method. The test results allow concluding that the created neural network makes a conclusion with a high degree of accuracy.

  7. Preliminary study of molecular imaging of human hepatocellular carcinoma xenograft with Gd-based MR probe containing arginine-glycine-aspartic acid chelate

    International Nuclear Information System (INIS)

    Huo Tianlong; Du Xiangke; Zhang Sen; Li Xubin; Liu Xia

    2008-01-01

    Objective: To develop a Gd-based MR probe containing arginine-glycine-aspartic acid (RGD) motif to reveal integrin αvβ3 receptor-expressed tumor. Methods: Commercially available HYNIC- RGD conjugate with co-ligand EDDA was labeled with GdCl 3 , and the mixture was isolated and purified by solid phase extract (SPE) to get the entire probe Gd-EDDA-HYNIC-RGD. Human HCC cell line BEL-7402 was cultured and the cells harvested and suspended then subcutaneously inoculated into athymic nude mice for tumor growth. In vitro cell binding assay to integrin αcβ3 receptor and cell viability experiments were conducted. Then in vivo, imaging of the three arms of xenografts were performed by MR scan with a dedicated animal coil at baseline and time points of 0, 30, 60, 90 minutes and 24 hour post-intravenous injection (p. i.) via the tail vein. Three arms of nude mice then were sacrificed for histological examination to confirm the imaging results. Results: Gd-EDDA-HYNIC-RGD was successfully isolated by SPE and validity was verified on signal enhancement through in vitro and in vivo experiments. The T 1 relaxation rate of the probe is 3.31 mmol/s; It is well tolerated to living cells when the concentration of the probe is below 0.1 μmol/ml; both BEL-7402 Human Hepatocellular Carcinoma cell line and the tumor expressed αvβ3 receptor; The RGD-ligand was observed specifically binding with αvβ3 receptor in vitro; The nude mice model bearing HHCC was well established. The signal intensity (SI) at the tumor site were 2247.6±39.0 at baseline and 2820.9±35.2 at 90 min p.i. respectively, the SI at 90 min increased less than 25% of baseline, which is statistically different (t=-38.031, P 0.05); The signal to time curve for probe-administrated group is straightforward over time in the span of 0 to 90 minute p.i. while the control arms do not show such tendency. Conclusion: Gd-EDDA-HYNIC-RGD has the potential to used as an MR probe detecting integrin αvβ3 receptor-expressed tumor

  8. Twenty years of children’s health monitoring: organization, results, conclusions

    Directory of Open Access Journals (Sweden)

    Aleksandra Anatol’evna Shabunova

    2015-05-01

    Full Text Available Deep understanding of human potential reproduction, presenting it as a continuous cycle and reflecting the continuity of generations, is significant for the formation of health and development of children. Today’s children will determine the future of Russian society. It is they who in 10–15 years will be a major part of the labor and creative population, a demographic base of the country. The research into children’s problems through the prism of socio-economic development helps identify targets of the state many-sided policy. The article presents results of the long-term medical sociological monitoring on the formation of child health carried out by the Institute of Socio-Economic Development of Territories of RAS with the support of the Vologda Oblast Healthcare Department since 1995. The special monitoring study of health dynamics in real time is unique not only for the Vologda Oblast, but for Russia as well. It reveals the transformation of a personality and the dependence of these changes on direct and indirect factors. The work’s feature is that it addresses an extremely important and wide range of issues: whether man was born healthy or not, if he/she is unhealthy, then why and why he/she was born unhealthy; whether his/her health after the birth is improving or deteriorating; if health is changing, what causes the changes. The 15 year observations disclose the dynamics of child health in the conditions of transformation processes taking place in the country. If the official statistics only records certain health trends, the monitoring results allow us to talk about them at a qualitatively new level. They reveal the underlying causes of demographic processes. The conclusion is, on the one hand, obvious and, on the other hand, it can not be neglected: economic stability and orderly development of the social sphere are critical for family well-being and child health. The reverse situation leads to the destruction of the family

  9. Alternative global goodness metrics and sensitivity analysis: heuristics to check the robustness of conclusions from studies comparing virtual screening methods.

    Science.gov (United States)

    Sheridan, Robert P

    2008-02-01

    We introduce two ways of testing the robustness of conclusions from studies comparing virtual screening methods: alternative "global goodness" metrics and sensitivity analysis. While the robustness tests cannot eliminate all biases in virtual screening comparisons, they are useful as a "reality check" for any given study. To illustrate this, we apply them to a set of enrichments published in McGaughey et al. (J. Chem. Inf. Model. 2007, 47, 1504-1519) where 11 target protein/ligand combinations are tested on 2D and 3D similarity methods, plus docking. The major conclusions in that paper, for instance, that ligand-based methods are better than docking methods, hold up. However, some minor conclusions, such as Glide being the best docking method, do not.

  10. Comparative evaluation of CT-based and respiratory-gated PET/CT-based planning target volume (PTV) in the definition of radiation treatment planning in lung cancer: preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Guerra, Luca; Elisei, Federica [San Gerardo Hospital, Nuclear Medicine, Monza (Italy); Meregalli, Sofia; Niespolo, Rita [San Gerardo Hospital, Radiotherapy, Monza (Italy); Zorz, Alessandra; De Ponti, Elena; Morzenti, Sabrina; Crespi, Andrea [San Gerardo Hospital, Medical Physics, Monza (Italy); Brenna, Sarah [University of Milan-Bicocca, School of Radiation Oncology, Monza (Italy); Gardani, Gianstefano [San Gerardo Hospital, Radiotherapy, Monza (Italy); University of Milan-Bicocca, Milan (Italy); Messa, Cristina [San Gerardo Hospital, Nuclear Medicine, Monza (Italy); University of Milan-Bicocca, Tecnomed Foundation, Milan (Italy); National Research Council, Institute for Bioimaging and Molecular Physiology, Milan (Italy)

    2014-04-15

    The aim of this study was to compare planning target volume (PTV) defined on respiratory-gated positron emission tomography (PET)/CT (RG-PET/CT) to PTV based on ungated free-breathing CT and to evaluate if RG-PET/CT can be useful to personalize PTV by tailoring the target volume to the lesion motion in lung cancer patients. Thirteen lung cancer patients (six men, mean age 70.0 years, 1 small cell lung cancer, 12 non-small cell lung cancer) who were candidates for radiation therapy were prospectively enrolled and submitted to RG-PET/CT. Ungated free-breathing CT images obtained during a PET/CT study were visually contoured by the radiation oncologist to define standard clinical target volumes (CTV1). Standard PTV (PTV1) resulted from CTV1 with the addition of 1-cm expansion of margins in all directions. RG-PET/CT images were contoured by the nuclear medicine physician and radiation oncologist according to a standardized institutional protocol for contouring gated images. Each CT and PET image of the patient's respiratory cycle phases was contoured to obtain the RG-CT-based CTV (CTV2) and the RG-PET/CT-based CTV (CTV3), respectively. RG-CT-based and RG-PET/CT-based PTV (PTV2 and PTV3, respectively) were then derived from gated CTVs with a margin expansion of 7-8 mm in head to feet direction and 5 mm in anterior to posterior and left to right direction. The portions of gated PTV2 and PTV3 geometrically not encompassed in PTV1 (PTV2 out PTV1 and PTV3 out PTV1) were also calculated. Mean ± SD CTV1, CTV2 and CTV3 were 30.5 ± 33.2, 43.1 ± 43.2 and 44.8 ± 45.2 ml, respectively. CTV1 was significantly smaller than CTV2 and CTV3 (p = 0.017 and 0.009 with Student's t test, respectively). No significant difference was found between CTV2 and CTV3. Mean ± SD of PTV1, PTV2 and PTV3 were 118.7 ± 94.1, 93.8 ± 80.2 and 97.0 ± 83.9 ml, respectively. PTV1 was significantly larger than PTV2 and PTV3 (p = 0.038 and 0.043 with Student's t test, respectively). No

  11. UVISS preliminary visibility analysis

    DEFF Research Database (Denmark)

    Betto, Maurizio

    1998-01-01

    The goal of this work is to obtain a preliminary assessment of the sky visibility for anastronomical telescope located on the express pallet of the International SpaceStation (ISS)} taking into account the major constraints imposed on the instrument by the ISSattitude and structure. Part of the w......The goal of this work is to obtain a preliminary assessment of the sky visibility for anastronomical telescope located on the express pallet of the International SpaceStation (ISS)} taking into account the major constraints imposed on the instrument by the ISSattitude and structure. Part...... of the work is also to setup the kernel of a software tool for the visibility analysis thatshould be easily expandable to consider more complex strucures for future activities.This analysis is part of the UVISS assessment study and it is meant to provide elementsfor the definition and the selection...

  12. Antares: preliminary demonstrator results

    International Nuclear Information System (INIS)

    Kouchner, A.

    2000-05-01

    The ANTARES collaboration is building an undersea neutrino telescope off Toulon (Mediterranean sea) with effective area ∼ 0.1 km 2 . An extensive study of the site properties has been achieved together with software analysis in order to optimize the performance of the detector. Results are summarized here. An instrumented line, linked to shore for first time via an electro-optical cable, has been immersed late 1999. The preliminary results of this demonstrator line are reported. (author)

  13. Combining State and Voluntary Provision: Using Volunteers in Home-Based Child Protection - Preliminary Indications for the Mental Wellbeing of Family Members

    Directory of Open Access Journals (Sweden)

    Jane Akister

    2013-07-01

    Conclusions: Volunteers can work effectively with complex families, working alongside statutory professional involvement. The volunteers are highly valued by the service users who report improved confidence in their parenting skills and improvements in their own mental wellbeing. Repeat measures support the service user’s reports of improvement in children’s emotional and behavioral wellbeing, family functioning and mother’s mental wellbeing.

  14. Preliminary results for the Co-Rolling process fabrication of plate-type nuclear fuel based in U-10Mo monolithic meat and zircaloy-4 cladding

    International Nuclear Information System (INIS)

    Pedrosa, Tercio A.; Brina, Jose Giovanni M.; Paula, Joao Bosco de; Lameiras, Fernando S.; Ferraz, Wilmar B.

    2013-01-01

    The fabrication process of plate-type nuclear fuel with monolithic meat is under development at CDTN. The U-10Mo alloy was chosen as the meat material due to its high density, corrosion resistance and the higher dimensional stability proportioned by the metastable gamma phase, which presents a lesser extension of the breakaway swelling phenomena occurrence during irradiation tests. The monolithic meat was cut from an U-10Mo ingot, that was induction melted at CDTN. The co-rolling process was adopted due to the higher mechanical properties and melting point of the Zircalloy-4 cladding material, which presents a lesser discrepancy in relation to the meat material properties, when compared to the aluminum 6061 alloy. Preliminary plates were obtained by means of the co-rolling process, performed at 650, 800, 950 deg C with total thickness reduction of 80%, followed by a pickling step and cold co-rolling passes. The plates were characterized through bending tests, optical microscopy and radiography. The co-rolling temperature of 800 deg C presented the best results, with a homogeneous distribution of the total thickness reduction between the cover plates and the meat, and the absence of delamination in the bending test samples. It was observed the occurrence of meat thickening in its ends, according to its longitudinal axle, parallel to the rolling direction, that is known as the d og bone , for the three co-rolling temperatures. (author)

  15. Ultrasonographic fetal growth charts: an informatic approach by quantitative analysis of the impact of ethnicity on diagnoses based on a preliminary report on Salentinian population.

    Science.gov (United States)

    Tinelli, Andrea; Bochicchio, Mario Alessandro; Vaira, Lucia; Malvasi, Antonio

    2014-01-01

    Clear guidance on fetal growth assessment is important because of the strong links between growth restriction or macrosomia and adverse perinatal outcome in order to reduce associated morbidity and mortality. Fetal growth curves are extensively adopted to track fetal sizes from the early phases of pregnancy up to delivery. In the literature, a large variety of reference charts are reported but they are mostly up to five decades old. Furthermore, they do not address several variables and factors (e.g., ethnicity, foods, lifestyle, smoke, and physiological and pathological variables), which are very important for a correct evaluation of the fetal well-being. Therefore, currently adopted fetal growth charts are inadequate to support the melting pot of ethnic groups and lifestyles of our society. Customized fetal growth charts are needed to provide an accurate fetal assessment and to avoid unnecessary obstetric interventions at the time of delivery. Starting from the development of a growth chart purposely built for a specific population, in the paper, authors quantify and analyse the impact of the adoption of wrong growth charts on fetal diagnoses. These results come from a preliminary evaluation of a new open service developed to produce personalized growth charts for specific ethnicity, lifestyle, and other parameters.

  16. Deep learning-based features of breast MRI for prediction of occult invasive disease following a diagnosis of ductal carcinoma in situ: preliminary data

    Science.gov (United States)

    Zhu, Zhe; Harowicz, Michael; Zhang, Jun; Saha, Ashirbani; Grimm, Lars J.; Hwang, Shelley; Mazurowski, Maciej A.

    2018-02-01

    Approximately 25% of patients with ductal carcinoma in situ (DCIS) diagnosed from core needle biopsy are subsequently upstaged to invasive cancer at surgical excision. Identifying patients with occult invasive disease is important as it changes treatment and precludes enrollment in active surveillance for DCIS. In this study, we investigated upstaging of DCIS to invasive disease using deep features. While deep neural networks require large amounts of training data, the available data to predict DCIS upstaging is sparse and thus directly training a neural network is unlikely to be successful. In this work, a pre-trained neural network is used as a feature extractor and a support vector machine (SVM) is trained on the extracted features. We used the dynamic contrast-enhanced (DCE) MRIs of patients at our institution from January 1, 2000, through March 23, 2014 who underwent MRI following a diagnosis of DCIS. Among the 131 DCIS patients, there were 35 patients who were upstaged to invasive cancer. Area under the ROC curve within the 10-fold cross-validation scheme was used for validation of our predictive model. The use of deep features was able to achieve an AUC of 0.68 (95% CI: 0.56-0.78) to predict occult invasive disease. This preliminary work demonstrates the promise of deep features to predict surgical upstaging following a diagnosis of DCIS.

  17. Yoga Meditation Practitioners Exhibit Greater Gray Matter Volume and Fewer Reported Cognitive Failures: Results of a Preliminary Voxel-Based Morphometric Analysis

    Directory of Open Access Journals (Sweden)

    Brett Froeliger

    2012-01-01

    Full Text Available Hatha yoga techniques, including physical postures (asanas, breathing exercises (pranayama, and meditation, involve the practice of mindfulness. In turn, yoga meditation practices may induce the state of mindfulness, which, when evoked recurrently through repeated practice, may accrue into trait or dispositional mindfulness. Putatively, these changes may be mediated by experience-dependent neuroplastic changes. Though prior studies have identified differences in gray matter volume (GMV between long-term mindfulness practitioners and controls, no studies to date have reported on whether yoga meditation is associated with GMV differences. The present study investigated GMV differences between yoga meditation practitioners (YMP and a matched control group (CG. The YMP group exhibited greater GM volume in frontal, limbic, temporal, occipital, and cerebellar regions; whereas the CG had no greater regional greater GMV. In addition, the YMP group reported significantly fewer cognitive failures on the Cognitive Failures Questionnaire (CFQ, the magnitude of which was positively correlated with GMV in numerous regions identified in the primary analysis. Lastly, GMV was positively correlated with the duration of yoga practice. Results from this preliminary study suggest that hatha yoga practice may be associated with the promotion of neuroplastic changes in executive brain systems, which may confer therapeutic benefits that accrue with repeated practice.

  18. Acceleration toward the conclusion negotiation of bilateral nuclear cooperation agreements indispensable for globalization

    International Nuclear Information System (INIS)

    Mitsumata, Hiroki; Hattori, Takuya; Ake, Yutaka

    2011-01-01

    According to Japan's basic policies of new growth strategy, it would be one option of the economic growth to increase exports of nuclear power plant system or its equipments. However, bilateral nuclear cooperation agreements are indispensable for business activities on nuclear power. Recently signature of agreement with Jordan, agreed conclusion negotiation with Vietnam and Korea, under negotiation with India and expected negotiation with Indonesia and Malaysia. Signed agreements with Russia and Kazakhstan will be coming into effect and contribute nuclear fuel supply at export of nuclear power system. This special article consists of four expert's papers titled as (1) necessity of conclusion negotiation of nuclear cooperation agreements with several countries simultaneously and in parallel, (2) Japan's nuclear cooperation in new era, (3) desirable acceleration of conclusion negotiation of nuclear cooperation agreements and (4) insurance of nuclear fuel supply fundamental for global business activities of Japan's nuclear industries-best choice to establish cooperative relations with US and Russia. (T. Tanaka)

  19. The grand leap of the whale up the Niagara Falls: converting philosophical conclusions into policy prescriptions.

    Science.gov (United States)

    Holm, Søren

    2015-04-01

    This article analyzes a neat conjuring trick employed in bioethics, that is, the immediate conversion of a philosophical conclusion into a policy prescription, and compares it to the "grand leap of the whale up the Niagara Falls" mentioned by Benjamin Franklin. It is shown that there is no simple and easy way to achieve the conversion, by considering arguments falling under four headings: (1) reasonable disagreement about values and theories, (2) general jurisprudential arguments, (3) the differences between policymaking and philosophy, and (4) the messy world of implementation. The particular issue used to illustrate the difficulties in moving from philosophical conclusion to policy description is infanticide of healthy infants, but the analysis is general, and the conclusion that the immediate move to policy is illegitimate is quite general.

  20. N Reactor Production Assurance Program blance of plant evaluation: report of findings and conclusions

    International Nuclear Information System (INIS)

    Hurd, E.N.; Bitten, E.J.

    1985-03-01

    Fourteen tasks were identified by UNC Nuclear Industries for evaluating the life expectancy of N Reactor structures, systems and components in the Balance of Plant portion of the Production Assurance Program. A Westinghouse Hanford Company (WHC) evaluation team was assigned to each of these fourteen tasks. A uniform set of criteria was used by all teams in evaluating the problems that may be encountered during the extended plant operating lifetime. The overall conclusion is that extended life to those Balance of Plant components and systems studied can be achieved. Problems with the potential for compromising that conclusion are identified, and feasible solutions are provided

  1. Optimal conclusive teleportation of a d-dimensional two-particle unknown quantum state

    Institute of Scientific and Technical Information of China (English)

    Yang Yu-Guang; Wen Qiao-Yan; Zhu Fu-Chen

    2006-01-01

    A conclusive teleportation protocol of a d-dimensional two-particle unknown quantum state using three ddimensional particles in an arbitrary pure state is proposed. A sender teleports the unknown state conclusively to a receiver by using the positive operator valued measure(POVM) and introducing an ancillary qudit to perform the generalized Bell basis measurement. We calculate the optimal teleportation fidelity. We also discuss and analyse the reason why the information on the teleported state is lost in the course of the protocol.

  2. Severe accident management (SAM), operator training and instrumentation capabilities - Summary and conclusions

    International Nuclear Information System (INIS)

    2002-01-01

    The Workshop on Operator Training for Severe Accident Management (SAM) and Instrumentation Capabilities During Severe Accidents was organised in collaboration with Electricite de France (Service Etudes et Projets Thermiques et Nucleaires). There were 34 participants, representing thirteen OECD Member countries, the Russian Federation and the OECD/NEA. Almost half the participants represented utilities. The second largest group was regulatory authorities and their technical support organisations. Basically, the Workshop was a follow-up to the 1997 Second Specialist Meeting on Operator Aids for Severe Accident Management (SAMOA-2) [Reports NEA/CSNI/R(97)10 and 27] and to the 1992 Specialist Meeting on Instrumentation to Manage Severe Accidents [Reports NEA/CSNI/R(92)11 and (93)3]. It was aimed at sharing and comparing progress made and experience gained from these two meetings, emphasizing practical lessons learnt during training or incidents as well as feedback from instrumentation capability assessment. The objectives of the Workshop were therefore: - to exchange information on recent and current activities in the area of operator training for SAM, and lessons learnt during the management of real incidents ('operator' is defined hear as all personnel involved in SAM); - to compare capabilities and use of instrumentation available during severe accidents; - to monitor progress made; - to identify and discuss differences between approaches relevant to reactor safety; - and to make recommendations to the Working Group on the Analysis and Management of Accidents and the CSNI (GAMA). The Workshop was organised into five sessions: - 1: Introduction; - 2: Tools and Methods; - 3: Training Programmes and Experience; - 4: SAM Organisation Efficiency; - 5: Instrumentation Capabilities. It was concluded by a Panel and General Discussion. This report presents the summary and conclusions: the meeting confirmed that only limited information is needed for making required decisions

  3. Preliminary study of highly cross-linked hyaluronic acid-based combination therapy for management of knee osteoarthritis-related pain

    Directory of Open Access Journals (Sweden)

    Palmieri B

    2013-01-01

    (49.5 mg plus sodium clodronate (5 mg into each knee. Patients also underwent blood tests for measurement of erythrocyte sedimentation rate (ESR and C-reactive protein (CRP immediately before and at 6-month follow-up.Results: Hyaluronic acid alone and in combination with sodium clodronate or diclofenac sodium produced a significant improvement in mean VAS pain score at 3 and 6-month follow-up. At 6-month follow-up, therapy with hyaluronic acid plus sodium clodronate was the most beneficial in terms of percentage improvement in VAS pain score. A significant improvement in ESR and CRP was observed at 6-month follow-up in each treatment group. No significant difference was observed when the percentage change from baseline related to these parameters was compared among the groups. No dropout was observed in any group. No serious adverse events were observed.Conclusion: Further studies are necessary to determine the effect of a therapy based on hyaluronic acid combined with diclofenac sodium or sodium clodronate in larger cohorts of patients affected by knee osteoarthritis and in longer-term follow-up.Keywords: osteoarthritis, hyaluronic acid, bisphosphonate, sodium clodronate, nonsteroidal anti-inflammatory drug, diclofenac sodium, viscosupplementation, combination therapy, knee, pain

  4. The medical eye: Conclusions from eye tracking research on expertise development in medicine

    NARCIS (Netherlands)

    Jarodzka, Halszka; Jaarsma, Thomas; Dewhurst, Richard; Boshuizen, Els

    2013-01-01

    Jarodzka, H., Jaarsma, T., Dewhurst, R., & Boshuizen, H. P. A. (2012, October). The medical eye: Conclusions from eye tracking research on expertise development in medicine. Paper presented at the New tools and practices for seeing and learning in medicine ’12, University of Turku, Turku, Finland.

  5. 19 CFR 210.63 - Proposed findings and conclusions and briefs.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Proposed findings and conclusions and briefs. 210.63 Section 210.63 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Temporary Relief § 210.63 Proposed findings...

  6. 19 CFR 210.40 - Proposed findings and conclusions and briefs.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Proposed findings and conclusions and briefs. 210.40 Section 210.40 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Prehearing Conferences and Hearings § 210...

  7. Conclusions and recommendations. [for problems in energy situation, air transportation, and hydrogen fuel

    Science.gov (United States)

    1973-01-01

    Conclusions and recommendations are presented for an analysis of the total energy situation; the effect of the energy problem on air transportation; and hydrogen fuel for aircraft. Properties and production costs of fuels, future prediction for energy and transportation, and economic aspects of hydrogen production are appended.

  8. 20 CFR 220.112 - Conclusions by physicians concerning the claimant's disability.

    Science.gov (United States)

    2010-04-01

    ... medically determinable physical or mental impairment which can be expected to result in death or which has... may have to consider such factors as age, education and past work experience. Such vocational factors... opinion by a treating source will be conclusive as to the medical issues of the nature and severity of a...

  9. Oklo: The fossil nuclear reactors. Physics study - Translation of chapters 6, 13 and conclusions

    Energy Technology Data Exchange (ETDEWEB)

    Naudet, R [CEA, Paris (France)

    1996-09-01

    Three parts of the 1991 book `Oklo: reacteurs nucleaires fossiles. Etude physique` have been translated in this report. The chapters bear the titles `Study of criticality`(45 p.), `Some problems with the overall functioning of the reactor zones`(45 p.) and `Conclusions` (15 p.), respectively.

  10. Oklo: The fossil nuclear reactors. Physics study - Translation of chapters 6, 13 and conclusions

    International Nuclear Information System (INIS)

    Naudet, R.

    1996-09-01

    Three parts of the 1991 book 'Oklo: reacteurs nucleaires fossiles. Etude physique' have been translated in this report. The chapters bear the titles 'Study of criticality'(45 p.), 'Some problems with the overall functioning of the reactor zones'(45 p.) and 'Conclusions' (15 p.), respectively

  11. Preliminary ethical appraisal of a trial - what's it all about?

    Science.gov (United States)

    Siipi, Helena

    Preliminary ethical appraisal of medical trials is often based on the following four principles: respect for autonomy, beneficence, non-maleficence, and justice. Preliminary ethical appraisal should, however, not be understood solely as application of these four principles to practice. Ethical committees will inevitably interpret the principles and make decisions about their reciprocal importance in connection with each trial. Reasoning does not always proceed from above towards practical recommendations of action, but can instead also be based on a moral rule or practice relating to a certain action. A good preliminary ethical appraisal will also take into account everyday standards of morality, law and shared moral values of the society.

  12. Preliminary studies of vanadium-base alloys intended for use in fabrication of cans for fast reactors; Etudes preliminaires sur les alliages a base de vanadium envisages pour la fabrication de gaines de reacteurs rapides

    Energy Technology Data Exchange (ETDEWEB)

    Conte, M [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1967-03-15

    Preliminary research has been carried out on a series of vanadium-based alloys: V, 0.5 per cent Si; V, 5 per cent Ca; V, 5 per cent Mo; V, 5 per cent Nb; V, 2 per cent Zr; V, 20 per cent Ti; V, 10 per cent Al; V, 10 per cent Sn and v, 10 per cent Ti liable to be used as canning material in fast reactors. The transformation by forging at about 1000 deg. C and rolling between 200 deg. C and room temperature is satisfactory for all types of alloys except V with 10 per cent Sn and V with 10 per cent Al. The mechanical properties deduced from tensile strength tests carried out on alloy samples annealed 1 hour at 1050 deg. C in a vacuum show that, generally speaking, the addition elements lead to an improvement in these properties as compared to those of pure vanadium. After undergoing corrosion tests in a liquid sodium loop purified by a cold trap, the alloys become brittle at room temperature. Only the vanadium containing 20 per cent Ti keeps its plastic properties. These alloys are covered by a layer of vanadium carbide VC. After undergoing treatment in a liquid sodium loop purified by a hot trap, all the alloys keep their good mechanical characteristics. The surface layer with which they are covered is composed of two vanadium carbides VC and {sub {gamma}}VC, and a vanadium sub-oxide VO{sub 0.9}. (author) [French] Des etudes preliminaires ont ete faites sur une serie d'alliages a base de vanadium: V-0,5 pour cent Si, V-5 pour cent Ca, V-5 pour cent Mo, V-5 pour cent Nb, V-2 pour cent Zr, V-20 pour cent Ti, V-10 pour cent Al, V-10 pour cent Sn et V-10 pour cent Ti susceptibles d'etre utilises comme materiau de gainage pour les reacteurs rapides. La transformation par forgeage a 1000 deg. C environ et laminage entre 200 deg. C et la temperature ambiante est satisfaisante pour toutes les nuances d'alliage sauf le V-10 pour cent Sn et le V-10 pour cent Al. Les proprietes mecaniques deduites des essais de traction realises sur des eprouvettes d'alliages recuits 1 heure a

  13. Environmental Survey preliminary report

    Energy Technology Data Exchange (ETDEWEB)

    1988-04-01

    This report presents the preliminary findings from the first phase of the Environmental Survey of the United States Department of Energy (DOE) Sandia National Laboratories conducted August 17 through September 4, 1987. The objective of the Survey is to identify environmental problems and areas of environmental risk associated with Sandia National Laboratories-Albuquerque (SNLA). The Survey covers all environmental media and all areas of environmental regulation. It is being performed in accordance with the DOE Environmental Survey Manual. This phase of the Survey involves the review of existing site environmental data, observations of the operations carried on at SNLA, and interviews with site personnel. 85 refs., 49 figs., 48 tabs.

  14. Ruiz Volcano: Preliminary report

    Science.gov (United States)

    Ruiz Volcano, Colombia (4.88°N, 75.32°W). All times are local (= GMT -5 hours).An explosive eruption on November 13, 1985, melted ice and snow in the summit area, generating lahars that flowed tens of kilometers down flank river valleys, killing more than 20,000 people. This is history's fourth largest single-eruption death toll, behind only Tambora in 1815 (92,000), Krakatau in 1883 (36,000), and Mount Pelée in May 1902 (28,000). The following briefly summarizes the very preliminary and inevitably conflicting information that had been received by press time.

  15. Licensing Support System: Preliminary data scope analysis

    International Nuclear Information System (INIS)

    1989-01-01

    The purpose of this analysis is to determine the content and scope of the Licensing Support System (LSS) data base. Both user needs and currently available data bases that, at least in part, address those needs have been analyzed. This analysis, together with the Preliminary Needs Analysis (DOE, 1988d) is a first effort under the LSS Design and Implementation Contract toward developing a sound requirements foundation for subsequent design work. These reports are preliminary. Further refinements must be made before requirements can be specified in sufficient detail to provide a basis for suitably specific system specifications. This document provides a baseline for what is known at this time. Additional analyses, currently being conducted, will provide more precise information on the content and scope of the LSS data base. 23 refs., 4 figs., 8 tabs

  16. Energy 2000: effects of the program and conclusions from its evaluation

    International Nuclear Information System (INIS)

    Balthasar, A.

    2000-01-01

    The action program Energy 2000 has been continually reviewed by independent experts in view of its effects. This resulted in around 50 scientific studies between 1991 and 1999, dealing with different aspects of the program. In the book 'Energy 2000: effects of the program and conclusions from its evaluation', the results of these evaluations are summarised, and conclusions for the design of the follow-up program are drawn. The organisational frame of the program is presented and the question answered whether the determining principles of the program proved practical. Besides, the effects of state intervention, of the conflict solving groups and the voluntary actions of Energy 2000 are appraised. A separate chapter is dedicated to the evaluation strategy of the program, its implementation and the benefits of the evaluations. Propositions for the evaluation of the follow-up program are formulated as well. Dr. Andreas Balthasar is President of the Swiss Evaluation Society. (author)

  17. Conclusions on the two technical panels on HLW-disposal and waste treatment processes respectively

    International Nuclear Information System (INIS)

    Dinkespiller, J.A.; Dejonghe, P.; Feates, F.

    1986-01-01

    The paper reports the concluding panel session at the European Community Conference on radioactive waste management and disposal, Luxembourg 1985. The panel considered the conclusions of two preceeding technical panels on high level waste (HLW) disposal and waste treatment processes. Geological disposal of HLW, waste management, safety assessment of waste disposal, public opinion, public acceptance of the manageability of radioactive wastes, international cooperation, and waste management in the United States, are all discussed. (U.K.)

  18. "Jumping to conclusions" in delusion-prone participants: an experimental economics approach.

    Science.gov (United States)

    van der Leer, Leslie; McKay, Ryan

    2014-01-01

    That delusional and delusion-prone individuals "jump to conclusions" on probabilistic reasoning tasks is a key finding in cognitive neuropsychiatry. Here we focused on a less frequently investigated aspect of "jumping to conclusions" (JTC): certainty judgments. We incorporated rigorous procedures from experimental economics to eliminate potential confounds of miscomprehension and motivation and systematically investigated the effect of incentives on task performance. Low- and high-delusion-prone participants (n = 109) completed a series of computerised trials; on each trial, they were shown a black or a white fish, caught from one of the two lakes containing fish of both colours in complementary ratios. In the betting condition, participants were given £4 to distribute over the two lakes as they wished; in the control condition, participants simply provided an estimate of how probable each lake was. Deviations from Bayesian probabilities were investigated. Whereas high-delusion-prone participants in both the control and betting conditions underestimated the Bayesian probabilities (i.e. were conservative), low-delusion-prone participants in the control condition underestimated but those in the betting condition provided accurate estimates. In the control condition, there was a trend for high-delusion-prone participants to give higher estimates than low-delusion-prone participants, which is consistent with previous reports of "jumping to conclusions" in delusion-prone participants. However, our findings in the betting condition, where high-delusion-prone participants provided lower estimates than low-delusion-prone participants (who were accurate), are inconsistent with the jumping-to-conclusions effect in both a relative and an absolute sense. Our findings highlight the key role of task incentives and underscore the importance of comparing the responses of delusion-prone participants to an objective rational standard as well as to the responses of non

  19. Chernobyl accident: causes and consequences (expert conclusion). Part 3. Chernobyl accident effect on Belarus

    International Nuclear Information System (INIS)

    Nesterenko, V.B.

    1992-01-01

    Expert conclusion is presented on the Chernobyl accident effect on Belarus. Problems of ground and food contamination, medical and biological radiation effects on the population are considered. Attention is paid to the radiation monitoring and radiometric gages. Scale of the damage for forestry and agriculture is described and recommendations on the agriculture is described and recommendations on the agricultural production and forest utilization at contaminated areas are given. 24 refs.; 4 figs.; 24 tabs

  20. Cognitive control in belief-laden reasoning during conclusion processing: An ERP study

    OpenAIRE

    Junlong Luo, Xiumin Du , Edward J. N. Stupple, Xiao Xiao, Lei Jia , Qinglin Zhang ,

    2012-01-01

    Belief-bias is the tendency to accept conclusions that are compatible with existing beliefs more frequently than those that contradict beliefs. It is one of the most replicated behavioral findings in the reasoning literature. Recently, neuroimaging studies using functional magnetic resonance imaging (fMRI) and event-related potentials (ERPs) have provided a new perspective and have demonstrated neural correlates of belief bias that have been viewed as supportive of dual process theories of be...