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Sample records for preliminary clinical investigation

  1. Emotion understanding in clinically anxious children: A preliminary investigation.

    OpenAIRE

    Bender, Patrick K; Francisco ePons; Harris, Paul L.; Barbara H. Esbjørn; Reinholdt-Dunne, Marie L.

    2015-01-01

    Children’s understanding of the nature, origins and consequences of emotions has been intensively investigated over the last 30–40 years. However, few empirical studies have looked at the relation between emotion understanding and anxiety in children and their results are mixed. The aim of the present study was to perform a preliminary investigation of the relationships between emotion understanding, anxiety, emotion dysregulation, and attachment security in clinically anxious children. A sam...

  2. Emotion understanding in clinically anxious children: A preliminary investigation

    Directory of Open Access Journals (Sweden)

    Patrick K. Bender

    2015-12-01

    Full Text Available Children’s understanding of the nature, origins and consequences of emotions has been intensively investigated over the last 30-40 years. However, few empirical studies have looked at the relation between emotion understanding and anxiety in children and their results are mixed. The aim of the present study was to perform a preliminary investigation of the relationships between emotion understanding, anxiety, emotion dysregulation, and attachment security in clinically anxious children. A sample of 16 clinically anxious children (age 8-12, 8 girls/boys was assessed for emotion understanding (Test of Emotion Comprehension, anxiety (Screening for Child Anxiety Related Emotional Disorders-Revised and Anxiety Disorder Interview Schedule, emotion dysregulation (Difficulties in Emotion Regulation Scale and attachment security (Security Scale. Children who reported more overall anxiety also reported greater difficulties in regulating their emotions, and were less securely attached to their parents. The results also showed that more specific symptoms of anxiety (i.e., OCD and PTSD correlated not only with emotion dysregulation and attachment insecurity but also with emotion understanding. Finally, there were interrelations among emotion understanding, attachment security, and emotion dysregulation. The present results provide the first comprehensive evidence for a socio-emotional framework and its relevance to childhood anxiety.

  3. Emotion Understanding in Clinically Anxious Children: A Preliminary Investigation.

    Science.gov (United States)

    Bender, Patrick K; Pons, Francisco; Harris, Paul L; Esbjørn, Barbara H; Reinholdt-Dunne, Marie L

    2015-01-01

    Children's understanding of the nature, origins and consequences of emotions has been intensively investigated over the last 30-40 years. However, few empirical studies have looked at the relation between emotion understanding and anxiety in children and their results are mixed. The aim of the present study was to perform a preliminary investigation of the relationships between emotion understanding, anxiety, emotion dysregulation, and attachment security in clinically anxious children. A sample of 16 clinically anxious children (age 8-12, eight girls/boys) was assessed for emotion understanding (Test of Emotion Comprehension), anxiety (Screening for Child Anxiety Related Emotional Disorders-Revised and Anxiety Disorder Interview Schedule), emotion dysregulation (Difficulties in Emotion Regulation Scale) and attachment security (Security Scale). Children who reported more overall anxiety also reported greater difficulties in regulating their emotions, and were less securely attached to their parents. The results also showed that more specific symptoms of anxiety (i.e., OCD and PTSD) correlated not only with emotion dysregulation and attachment insecurity but also with emotion understanding. Finally, there were interrelations among emotion understanding, attachment security, and emotion dysregulation. The present results provide the first comprehensive evidence for a socio-emotional framework and its relevance to childhood anxiety.

  4. Preliminary clinical investigations of a new noninvasive venous pulse oximeter

    Science.gov (United States)

    Chan, Daniel; Smith, Peter R.; Caine, Michael P.; Spyt, Tomasz; Boehm, Maria; Machin, David

    2003-10-01

    For decades, the monitoring of mixed venous oxygen saturation, SvO2 has been performed invasively using fibre-optic catheters. This procedure is not without risk as complications may arise from catheterisation. The group has devised a new non-invasive venous oximetry method which involves inducing regular modulations of the venous blood volume and associated measurement of those modulations using optical means. A clinical investigation was conducted in Glenfield Hospital, UK to evaluate the sensitivity of the new technique to haemodynamic changes such as Cardiac Output (CO) in intraoperative and postoperative cardiac patients. Preliminary trials on patients recovering from cardiac surgery yielded an average correlation of r = 0.72 between CO at different Intra Aortic Balloon Pump (IABP) augmentation levels and SvO2 measured by the new venous oximeter. In intraoperative patients undergoing off-pump cardiac surgery, SvO2 recorded by the new technique responded to unplanned events such as a cardiac arrest. CONCLUSION: The new venous oximetry technique is a promising technique which responds to haemodynamic changes such as CO and with further development might offer an alternative means of monitoring SvO2 non-invasively.

  5. Clinical classification of chronic prostatitis: a preliminary investigation

    Institute of Scientific and Technical Information of China (English)

    Wei-DongHUANG; PeiLIU; Wen-JieHUANG

    2000-01-01

    Aim: To propose a practical clinical classification for the chronic prostatitis (CP). Methods: The clinical features and the findings in the expressed prostatic secretion (EPS) in 804 cases of CP patients were retrospectively analyzed. Results: Four types of CP were identified based on the clinical manifestations and the amounts of white blood cells (WBC) and lecithin in EPS. They were the latent type (85 cases; 10.6%), the common type (423 cases;52.6%), the persisting type (104 cases; 12.9%), and the active type (192 cases, 23.9%). The therapeutic efficacy for these 4 subtypes were 40.4%, 76.8%, 30.8% and 37%, respectively; a statistical difference was noticed between the common type and the persisting type (P<0.01). Conclusion: The method of classification proposed by the authors may help clinicians in the diagnosis and predicting the prognosis of CP. (Asian J Androl 2000 Dec;2:311-313)

  6. Preliminary clinical pharmacological investigations of tylosin and tiamulin in chickens.

    Science.gov (United States)

    Ziv, G

    1980-10-15

    The minimal inhibitory concentrations (MIC) of tiamulin and tylosin for mycoplasma, Gram-positive, and Gram-negative micro-organisms isolated from chickens were determinated by the agar dilution method. Median MIC values for tiamulin against Mycoplasma gallisepticum (0.05 microgram/ml) and Mycoplasma synoviae (0.10 microgram/ml) were 2 to 4 times lower than the corresponding values for tylosin. Tiamulin was also slightly more effective in vitro in inhibiting Escherichia coli, Pasteurella multocida, and beta-haemolytic streptococci than was tylosin. Groups of chicken were offered tiamulin medicated drinking water at rates of 125 and 250 mg/litre for 48 hours. Average serum tiamulin concentrations were 0.38 and 0.78 microgram/ml, respectively. When tylosin tartrate was added to the drinking water at 500 and 700 mg/litre, average serum drug levels were 0.12 and 0.17 microgram/ml, respectively. Tiamulin was 45% bound in chicken serum, as against 30% serum protein binding for tylosin. Correlations were made between free (non protein bound) serum drug levels and the MIC values of the two drugs. Such comparisons suggest that when tiamulin is given in the drinking water at rates of 125 to 250 mg/litre, better antimycoplasmal activity is to be expected in vivo than by giving tylosin tartrate in the drinking water at 500 to 700 mg/litre. Based on these data, no clinical efficacy of these dose rates can be expected in flocks infected by gram-negative micro-organisms such as E. coli or P. multocida. The tylosin tartrate rate of 500 to 700 mg/litre, may be clinical ineffective the treatment of Staphylococcus aureus infections.

  7. A Preliminary Clinical Laboratory Investigation of Endemic Spiking Mortality Syndrome of Broiler Chickens in Nepal

    Directory of Open Access Journals (Sweden)

    Tika Ram Neupane

    Full Text Available During the period of March-April-May 2008 first time a sudden and unexpected jump in mortality in Broiler of 8 to 16 days of age was reported from broiler farms from Chitwan and Kathmandu valley in Nepal.Affected birds become recumbent, depressed and often go into a star-gazing spasm. Those signs included, huddling of the birds, trembling, blindness, loud chirping, litter eating, ataxia, comatose, birds dead with breast down and feet and legs straight out behind birds. Death within two to six hours after the onset of the symptoms Postmortem Lesions found with this syndrome include hemorrhages in the liver with necrosis of liver cells, regressed thymus, regression of the bursa of Fabricius, dehydration with the accumulation of kidney urates, fluid in the crop, fluid in the lower gut and watery contents of the ceca.Yellow elastic shanks swollen joints. Molted appearance of brain. . The mortality lasted for three to five days, after which, the mortality patterns return to a relatively normal level. When treated with liquid toxin binders like toxol,toxolivum,livertonic like hepatocare,naturaliv, immunomodulaters like immunocare,promin,pentasol and antibiotics there was check in mortality but the body weight recovery was not satisfactory only half as in comparison of in other illness. During this period laboratory culture of total 298 tissue specimen from dead bird was conducted which revealed growth of fungus spp like Aspergillus and Penicillium in 182 specimen while mixed E.coli and Staphylococcus were recovered in 68 specimen 24 specimen revealed the growth of Salmonella spp of bacteria and 24 samples were turn out to be negative while the attempt to isolate the Avian encephalomyelitis virus as it might be the cause suspected also turnout negative. On the basis of all laboratory findings and response to the treatment attempted finding of this preliminary investigation work is suggestive that the above syndrome indicates that mycosis emerging as

  8. Frequency, Clinical Correlates, and Ratings of Behavioral Changes in Primary Brain Tumor Patients: A Preliminary Investigation

    OpenAIRE

    Simpson, Grahame K.; Eng-Siew eKoh; Diane eWhiting; Wright, Kylie M.; Teresa eSimpson; Rochelle eFirth; Lauren eGillett; Kathryn eYounan

    2015-01-01

    Purpose Few studies have addressed the specific behavioral changes associated with primary brain tumor (PBT). This paper will report on the frequency and demographic/clinical correlates of such behaviors, and the reliability of rating such behaviors among people with PBT, family informants, and clinicians. The association of behavioral changes and patient functional status will also be discussed. Methods A total of 57 patients with 37 family informants were recruited from two large...

  9. Clinical Investigation.

    Science.gov (United States)

    1979-09-30

    Hiller, D.A., Elliott, J.P.: Tubal Ligation Syndrome Myth or Reality. Presented: Armed Forces Division of ACOG, New Orleans, Louisiana, October 1977...Molecular Weight Immunoreactive Glucagon Levels in Patients with the Post Prandial Syndrome . (Abst.) Western Society for Clinical Research, 1979. (3...Glucagon Levels in Patients witl the Post Prandial Syndrome . Presented: Western Society Meetings, Western Society for Clinical Research, February 1979. (3

  10. Clinical audit of posterior three-unit fixed-movable resin-bonded fixed partial dentures - A retrospective, preliminary clinical investigation.

    Science.gov (United States)

    Botelho, Michael G; Dyson, John E; Mui, Thomas H F; Lam, Walter Y H

    2017-02-01

    Two-unit cantilevered resin-bonded fixed partial dentures (RBFPDs) have higher retention rates over longer span fixed-fixed RBFPDs. It has been hypothesized that interabutment stresses associated with fixed-fixed designs cause prosthesis debonds therefore for the replacement of molar-sized and longer spans, non-rigid connectors have been used to allow independent movement between two abutment teeth. This preliminary study evaluates the clinical longevity and subjects' satisfaction of three-unit fixed-movable (FM3) RBFPDs provided at a dental teaching hospital. Subjects who had received FM3 RBFPD(s) in the posterior region were clinically reviewed for complications. History of any debonds and subjects' satisfaction to the prosthesis was recorded. Time-to-debond (retention rate) and time-to-loss (survival rate) of these prostheses were presented in life tables. Ninety-eight prostheses in 84 subjects were examined. Their mean service life was 31.8 months (SD 11.5, range 3-67 months). Twenty-two prostheses had a history of debond, resulting in a retention proportion of 77.6%; seventeen of these were rebonded and still present at the time of review. One prosthesis was lost after extraction of a periodontally-involved abutment tooth, giving a survival proportion of 93.9%. High subject satisfaction and no adverse outcome were reported. Three-unit fixed-movable RBFPDs have a shorter success than two-unit cantilevered RBFPDs. However, non-rigid connectors allow the possibility of rebonding giving satisfactory short-term survival rate. Further research is needed to investigate their long-term efficacy. Three-unit fixed-movable RBFPDs incorporating non-rigid connectors may be a feasible option for replacement of molar-size pontic in the posterior region. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. Preliminary Investigation of a Paraglider

    Science.gov (United States)

    Rogallo, Francis M.; Lowry, John G.; Croom, Delwin R.; Taylor, Robert T.

    1960-01-01

    A preliminary investigation of the aerodynamic and control characteristics of a flexible glider similar to a parachute in construction has been made at the Langley Research Center to evaluate its capabilities as a reentry glider. Preliminary weight estimates of the proposed vehicle indicate that such a structure can be made with extremely low wing loading. Maximum temperatures during the reentry maneuver might be held as low as about 1,500 F. The results of wind-tunnel and free-glide tests show that the glider when constructed of nonporous material performed extremely well at subsonic speeds and could be flown at angles of attack from about 200 to 900. At supersonic speeds the wing showed none of the unfavorable tendencies exhibited by conventional parachutes at these speeds, such as squidding and breathing. Several methods of packing and deploying the glider have been successfully demonstrated. The results of this study indicate that this flexible-lifting-surface concept may provide a lightweight controllable paraglider for manned space vehicles.

  12. 18 CFR 1b.6 - Preliminary investigations.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Preliminary investigations. 1b.6 Section 1b.6 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.6 Preliminary investigations....

  13. 42 CFR 457.925 - Preliminary investigation.

    Science.gov (United States)

    2010-10-01

    ... (CONTINUED) STATE CHILDREN'S HEALTH INSURANCE PROGRAMS (SCHIPs) ALLOTMENTS AND GRANTS TO STATES Program Integrity § 457.925 Preliminary investigation. If the State agency receives a complaint of fraud or abuse...

  14. Future requirements. Clinical investigations

    DEFF Research Database (Denmark)

    Qvist, V.

    2002-01-01

    Biocompatability, Cariology, Clinical trials, Dental materials, Helath services research, Human, Pedodontics......Biocompatability, Cariology, Clinical trials, Dental materials, Helath services research, Human, Pedodontics...

  15. Archaeogeophysical investigations in Tiwanaku: preliminary results

    Science.gov (United States)

    Masini, Nicola; Sileo, Maria; Lasaponara, Rosa; Leucci, Giovanni; Orefici, Giuseppe; Rizzo, Enzo

    2017-04-01

    -1450) Tiwanaku was characterized by the resurgence of regional identities and polities In spite of the rich archaeological record numerous issues, related to the function and the extension of Tiwanaku, need to be investigated especially in the monumental core which includes the pyramid of Akapana, and other ceremonial places such Kalasasaya, Putuni and Kantatallita. To this aims some geophysical investigations were performed in 2009 and 2014 in the context of multidisciplinary research including the use of satellite remote sensing [8]. This paper deals with the discussion of preliminary results of geomagnetic and GPR investigations, some of which have been verified by trial archaeological excavations which have unearthed some buried structures, improving the knowledge of the ceremonial areas of Tiwanaku. References [1] Lasaponara R., Leucci G., Masini N., Persico R., Scardozzi G., Towards an operative use of remote sensing for exploring the past using satellite data: The case study of Hierapolis (Turkey), Remote sensing of Environment, 174 (2016) : 148-164, doi:10.1016/j.rse.2015.12.016 [2] Masini N., Lasaponara R., Rizzo E., Orefici G. 2012. Integrated Remote Sensing Approach in Cahuachi (Peru): Studies and Results of the ITACA Mission (2007-2010), In: Lasaponara R., Masini N. (Eds) 2012, Satellite Remote Sensing: a new tool for Archaeology, Springer, Verlag Berlin Heidelberg, ISBN 978-90-481-8800-0, doi: 10.1007/978-90-481-8801-7_14; pp. 307-344 [3] Rizzo E., Masini N., Lasaponara R., Orefici G. 2010, ArchaeoGeophysical methods in the Templo del Escalonado (Cahuachi, Nasca, Perù), Near Surface Geophysics 8 (5), 433-439, doi:10.3997/1873-0604.2010030 [4] Masini N., Rizzo E., Lasaponara R., and Orefici G. 2008, Integrated remote sensing techniques for the detection of buried archaeological adobe structures: preliminary results in Cahuachi (Peru), Advances in Geosciences, 19, 75-82 [5] Lasaponara R., Leucci G., Masini N., Persico R. 2014. Investigating archaeological looting

  16. Preliminary investigation into the possible endocrine disrupting ...

    African Journals Online (AJOL)

    JTEkanem

    In this study, we quantified the effect of Bonny- light crude oil contaminated diet ... This preliminary result suggest that Bonny-Light crude oil may have the potential .... different components. Its exploration ... organisms found in crude oil polluted.

  17. Clinical Investigator Inspector List (CLIIL)

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Clinical Investigator Inspection List (CLIIL) contains names, addresses, and other pertinent information gathered from inspections of clinical investigators who...

  18. Preliminary investigations of piezoelectric based LED luminary

    DEFF Research Database (Denmark)

    Nielsen, Dennis; Andersen, Michael A. E.; Meyer, Kaspar Sinding

    2011-01-01

    This paper presents a preliminary study of PT (Piezoelectric Transformer) based SMPS’s (Switch Mode Power Supplies) for LED luminary. The unique properties of PTs (efficiency, power density and EMI) make them highly suitable for this application. Power stage topologies, rectifiers circuits, modul...

  19. Preliminary rock mechanics laboratory: Investigation plan

    Energy Technology Data Exchange (ETDEWEB)

    Oschman, K.P.; Hummeldorf, R.G.; Hume, H.R.; Karakouzian, M.; Vakili, J.E.

    1987-01-01

    This document presents the rationale for rock mechanics laboratory testing (including the supporting analysis and numerical modeling) planned for the site characterization of a nuclear waste repository in salt. This plan first identifies what information is required for regulatory and design purposes, and then presents the rationale for the testing that satisfies the required information needs. A preliminary estimate of the minimum sampling requirements for rock laboratory testing during site characterization is also presented. Periodic revision of this document is planned.

  20. Preliminary clinical and pharmacologic investigation of photodynamic therapy with the silicon phthalocyanine photosensitizer Pc 4 for primary or metastatic cutaneous cancers

    Directory of Open Access Journals (Sweden)

    Timothy James Kinsella

    2011-06-01

    Full Text Available Photodynamic therapy (PDT for cutaneous malignancies has been found to be an effective treatment with a range of photosensitizers. The phthalocyanine Pc 4 was developed initially for PDT of primary or metastatic cancers in the skin. A Phase I trial was initiated to evaluate the safety and pharmacokinetic profiles of systemically administered Pc 4 followed by red light (Pc 4-PDT in cutaneous malignancies. A dose-escalation study of Pc 4 (starting dose 0.135 mg/m2 at a fixed light fluence (135 J/cm2 of 675-nm light was initiated in patients with primary or metastatic cutaneous malignancies with the aim of establishing the maximum tolerated dose (MTD. Blood samples were taken at intervals over the first 60 hours post-PDT for pharmacokinetic analysis, and patients were evaluated for toxicity and tumor response. A total of 3 patients (2 females with breast cancer and 1 male with cutaneous lymphoma were enrolled and treated over the dose range of 0.135 mg/m2 (first dose level to 0.54 mg/m2 (third dose level. Grade 3 erythema within the photoirradiated area was induced in patient 2, and transient tumor regression in patient 3, in spite of the low photosensitizer doses. Pharmacokinetic observations fit a 3-compartment exponential elimination model with an initial rapid distribution phase (~0.2 hrs and relatively long terminal elimination phase (~28 hrs, Because of restrictive exclusion criteria and resultant poor accrual, the trial was closed before MTD could be reached. While the limited accrual to this initial Phase I study did not establish the MTD nor establish a complete pharmacokinetic and safety profile of intravenous Pc 4-PDT, these preliminary data support further Phase I testing of this new photosensitizer.

  1. Preliminary clinical and pharmacologic investigation of photodynamic therapy with the silicon phthalocyanine photosensitizer pc 4 for primary or metastatic cutaneous cancers.

    Science.gov (United States)

    Kinsella, Timothy James; Baron, Elma D; Colussi, Valdir C; Cooper, Kevin D; Hoppel, Charles L; Ingalls, Stephen T; Kenney, Malcolm E; Li, Xiaolin; Oleinick, Nancy L; Stevens, Seth R; Remick, Scot C

    2011-01-01

    Photodynamic therapy (PDT) for cutaneous malignancies has been found to be an effective treatment with a range of photosensitizers. The phthalocyanine Pc 4 was developed initially for PDT of primary or metastatic cancers in the skin. A Phase I trial was initiated to evaluate the safety and pharmacokinetic profiles of systemically administered Pc 4 followed by red light (Pc 4-PDT) in cutaneous malignancies. A dose-escalation study of Pc 4 (starting dose 0.135 mg/m(2)) at a fixed light fluence (135 J/cm(2) of 675-nm light) was initiated in patients with primary or metastatic cutaneous malignancies with the aim of establishing the maximum tolerated dose (MTD). Blood samples were taken at intervals over the first 60 h post-PDT for pharmacokinetic analysis, and patients were evaluated for toxicity and tumor response. A total of three patients (two females with breast cancer and one male with cutaneous T-cell lymphoma) were enrolled and treated over the dose range of 0.135 mg/m(2) (first dose level) to 0.54 mg/m(2) (third dose level). Grade 3 erythema within the photoirradiated area was induced in patient 2, and transient tumor regression in patient 3, in spite of the low photosensitizer doses. Pharmacokinetic observations fit a three-compartment exponential elimination model with an initial rapid distribution phase (∼0.2 h) and relatively long terminal elimination phase (∼28 h), Because of restrictive exclusion criteria and resultant poor accrual, the trial was closed before MTD could be reached. While the limited accrual to this initial Phase I study did not establish the MTD nor establish a complete pharmacokinetic and safety profile of intravenous Pc 4-PDT, these preliminary data support further Phase I testing of this new photosensitizer.

  2. Clinical Investigation Program.

    Science.gov (United States)

    1987-09-30

    Houston Gerald B. Merenstein, MD, Univ. of Colo. Health Sciences Center (9) Dept of Pediatri -cs" . . . (10) Associate Investigators (11) Key Words...Patsology (10) Assoc’f ef Js1gators Willis Rieker, CPT, MC (11) Key Words: Rick E. Martinez , DAC blood component removal Judy Barber, DAC Patricia...89 Markowski, J.------------------------- 174 Martinez , R.-------------------------- 273 McCubbin, J.A.------------------------ 143 McCullen

  3. Preliminary investigations of piezoelectric based LED luminary

    DEFF Research Database (Denmark)

    Nielsen, Dennis; Andersen, Michael A. E.; Meyer, Kaspar Sinding

    2011-01-01

    This paper presents a preliminary study of PT (Piezoelectric Transformer) based SMPS’s (Switch Mode Power Supplies) for LED luminary. The unique properties of PTs (efficiency, power density and EMI) make them highly suitable for this application. Power stage topologies, rectifiers circuits......, modulation schemes, LEDs and LED driving conditions are analyzed. A prototype radial mode PT optimized for ZVS (Zero Voltage Switching) is designed. FEM (Final Element Method) and measurements validates the PT design. A prototype PT based AC/DC converter operating from european mains is proposed...

  4. Psychache and Suicide: A Preliminary Investigation

    Science.gov (United States)

    Pompili, Maurizio; Lester, David; Leenaars, Antoon A.; Tatarelli, Roberto; Girardi, Paolo

    2008-01-01

    Shneidman's Psychological Pain Assessment Scale (PPAS; 1999) was administered to 88 psychiatric patients. Both current and worst-ever psychache were significantly higher in those patients judged by a psychiatrist, on the basis of a structured clinical interview, to be at risk of suicide. However, current and worst-ever psychache were not…

  5. Preliminary clinical results with the ISL laser

    Science.gov (United States)

    Hoppeler, Thomas; Gloor, Balder

    1992-08-01

    The ISL laser (Intelligent Surgical Lasers, Inc.), a Nd:YLF picosecond pulse laser, is currently being used under investigational device exemption to perform microsurgery of the anterior segment of the eye. At different study sites procedures for cataract fragmentation and iridotomy, as well as for posterior capsulotomy after cataract surgery, are under evaluation. Other potential applications include: sclerostomy ab interno, the cutting of membranes in the anterior and posterior segment of the eye; corneal incisions; and corneal intrastromal effects. We discuss various clinically relevant aspects of the use of this picosecond laser. An overview of different computer controlled laser patterns is given.

  6. Examining the Reinforcing Properties of Making Sense: A Preliminary Investigation

    Science.gov (United States)

    Wray, Alisha M.; Dougher, Michael J.; Hamilton, Derek A.; Guinther, Paul M.

    2012-01-01

    Acceptance and commitment therapy asserts that in clinical problems such as rumination and depression, making sense continues despite accompanying aversive consequences, because sense-making is reinforcing, particularly when it leads to experiential avoidance. The following series of experiments aimed to provide preliminary empirical evidence for…

  7. Preliminary Investigation of Profiling Tools and Methods

    Science.gov (United States)

    2011-06-01

    Minister of National Defence, 2011 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2011...indicate the need for further investigations to be able to support or negate the usefulness of GP. The critique of GP suggests that “results show...C., Jones, N.J., Taylor, P.J. & Snook, B. (2006). “Validities and Abilities in Criminal Profiling: A Critique of the Studies Conducted by Richard

  8. PRELIMINARY PHYTOCHEMICAL AND HISTOCHEMICAL INVESTIGATION ON KIGELIA PINNATA DC.,

    Directory of Open Access Journals (Sweden)

    DHANASEKARAN.M

    2014-07-01

    Full Text Available Kigelia pinnata D.C. the mid sized ornamental tree of the Bignoniaceae has been studied by preliminary phytochemical and histochemical analysis. Several local names are availability to this plants based on their country. They are called worsboom in Africa and sauage tree in America. The tree is 25 meters in hight with a dense rounded crown bark grey. Data gathered on solvent extraction and preliminary phytochemical method suggested that the presence of glycosides, flavonoides, tannin and alkaloids in leaf tissue. Anatomical and histochemical investigation offered some clues on the localization of certain specific metabolites. This paper revealed preliminary phytochemical constituents of Kigelia pinnta D.C.., by phytochemical and histochemical investigation.

  9. Preliminary investigation on professionalism assessment of the students of clinical medical majors%临床医学专业学生职业素养评估的初步探索

    Institute of Scientific and Technical Information of China (English)

    续岩; 王维民; 辛兵

    2008-01-01

    随着现代医学和医学教育的发展,对医学生的综合素质提出了更高的要求.为此,北京大学医学部对临床医学专业学生进行了职业素养评估的初步探索.结果 表明,在职业价值、人际交流技能、群体健康和批判性思维与研究4项指标上,被评估的学生总体表现良好,其中人际交流技能的优秀率最高,而批判性思维与研究的优秀率最低.实践证明,医学生职业素养评估方法是可行的,且有待于进一步完善.%With the development of modern medicine and medical education, the medical students are being evaluated with even higher standards. Therefore, Peking University Health Science Center (PKU- HSC) initiated the preliminary investigation on the professionalism assessment of the students of clinical medical majors. The result revealed that the assessed students are satisfactory on the four aspects such as professional values, communication skills, population health, and critical thinking & research. In addi- tion, the excellent rate of communication skills is the highest, and that of critical thinking & research is the lowest. The professionalism assessment model is feasible, yet it should be further improved.

  10. 78 FR 63988 - Clinical Investigator Training Course

    Science.gov (United States)

    2013-10-25

    ... investigators on issues of greatest importance for successful clinical research. Date and Time: The training... FDA to communicate directly with clinical investigators on issues of greatest importance for... medicine; Promote communication between clinical investigators and FDA; Enhance...

  11. Preliminary Clinical Evaluation: The What, Where, How Approach to Scoring

    OpenAIRE

    Wright, C.; Akimoto, T.

    2016-01-01

    The SCoR is driving for preliminary clinical evaluation (PCE) however; currently there is no method of quantification to assess quality. FRCR has an approach to quantify comments in the rapid reporting examination (CR2B).The aim of this project was to develop a robust scoring system that enables comprehensive image evaluation regardless of profession. An image test bank was administered using RadBench with equal prevalence of normal /abnormal. A random sample of attempts was selected to pilot...

  12. Photodynamic therapy of port wine stain: preliminary clinical studies

    Science.gov (United States)

    Nelson, J. Stuart

    1993-07-01

    The broad, long term objective of this work is the development of Photodynamic Therapy (PDT) for application in the clinical management of patients with port wine stain (PWS). PDT involves the use of an exogenous drug which is concentrated in a targeted tissue. When irradiated at wavelengths specifically absorbed by the drug, selective destruction of the targeted tissue, without the production of heat, occurs. The results of this preliminary study demonstrate in human PWS patients that a photosensitizer, such as PHOTOFRINR, activated by red light at the appropriate therapeutic wavelength, can cause destruction of subsurface blood vessels in the skin with a high degree of specificity, and further study appears warranted.

  13. Laboratory Investigations on Estuary Salinity Mixing: Preliminary Analysis

    Directory of Open Access Journals (Sweden)

    F. H. Nuryazmeen

    2014-05-01

    Full Text Available Estuaries are bodies of water along the coasts that are formed when fresh water from rivers flows into and mixes with salt water from the ocean. The estuaries serve as a habitat to some aquatic lives, including mangroves. Human-induced activities such as dredging of shipping lanes along the bottom estuarine, the disposal of industrial wastes into the water system and shoreline development influence estuarine dynamics which include mixing process. These activities might contribute to salinity changes and further adversely affect the estuarine ecosystem. In order to study at the characteristics of the mixing between salt water (estuary and freshwater (river, a preliminary investigation had been done in the laboratory. Fresh water was released from one end of the flume and overflowing at weir at the other end. Meanwhile, salt water was represented by the red dye tracer released through a weir and intruded upstream as a gravity current. The isohalines are plotted to see the salinity patterns. Besides, to examine the spatial and temporal salinity profiles along the laboratory investigations, the plotted graphs have been made. The results show that the changes in salinity level along the flume due to mixing between fresh water and salt water. This showed typical salt-wedge estuary characteristics.

  14. Preliminary investigations of the rhizosphere nature of hydroponically grown lettuces

    Science.gov (United States)

    Antunes, Inês; Paille, Christel; Lasseur, Christophe

    Due to capabilities of current launchers, future manned exploration beyond the Earth orbit will imply long journeys and extended stays on planet surfaces. For this reason, it is of a great importance to develop a Regenerative Life Support System that enables the crew to be, to a very large extent, metabolic consumables self-sufficient. In this context, the European Space Agency, associated with a scientific and engineering con-sortium, initiated in 1989 the Micro-Ecological Life Support System Alternative (MELiSSA) project. This concept, inspired on a terrestrial ecosystem (i.e. a lake), comprises five intercon-nected compartments inhabited by micro-organisms and higher-plants aiming to produce food, fresh water, and oxygen from organic waste, carbon dioxide, and minerals. Given the important role of the higher-plant compartment for the consumption of carbon dioxide and the production of oxygen, potable water, and food, it was decided to study the microbial communities present in the root zone of the plants (i.e. the rhizosphere), and their synergistic and antagonistic influences in the plant growth. This understanding is important for later investigations concerning the technology involved in the higher plant compartment, since the final goal is to integrate this compartment inside the MELiSSA loop and to guarantee a healthy and controlled environment for the plants to grow under reduced-gravity conditions. To perform a preliminary assessment of the microbial populations of the root zone, lettuces were grown in a hydroponic system and their growth was characterized in terms of nutrient uptake, plant diameter, and plant wet and dry weights. In parallel, the microbial population, bacteria and fungi, present in the hydroponic medium and also inside and outside the roots were analyzed in terms of quantity and nature. The goal of this presentation is to give a preliminary review in the plant root zone of the micro-organisms communities and as well their proportions

  15. Medical Services: Clinical Investigation Program

    Science.gov (United States)

    2007-11-02

    epidemiological surveys that involve tests or procedures of no more than minimal risk. (See the glossary for the definition of an epidemiological survey... definite criteria.) b. Who will be notified. G–10. Adverse reactions Include— a. Definition of subject reactions. b. Immediate reporting. c. Routine...some laser and hemodialysis systems. Subinvestigator See associate investigator. Test A p r o c e s s b y w h i c h d a t a a c c u m u l a t e d t o

  16. Preliminary investigations into triazole derived androgen receptor antagonists.

    Science.gov (United States)

    Altimari, Jarrad M; Niranjan, Birunthi; Risbridger, Gail P; Schweiker, Stephanie S; Lohning, Anna E; Henderson, Luke C

    2014-05-01

    A range of 1,4-substituted-1,2,3-N-phenyltriazoles were synthesized and evaluated as non-steroidal androgen receptor (AR) antagonists. The motivation for this study was to replace the N-phenyl amide portion of small molecule antiandrogens with a 1,2,3-triazole and determine effects, if any, on biological activity. The synthetic methodology presented herein is robust, high yielding and extremely rapid. Using this methodology a series of 17 N-aryl triazoles were synthesized from commercially available starting materials in less than 3h. After preliminary biological screening at 20 and 40 μM, the most promising three compounds were found to display IC50 values of 40-50 μM against androgen dependent (LNCaP) cells and serve as a starting point for further structure-activity investigations. All compounds in this work were the focus of an in silico study to dock the compounds into the human androgen receptor ligand binding domain (hARLBD) and compare their predicted binding affinity with known antiandrogens. A comparison of receptor-ligand interactions for the wild type and T877A mutant AR revealed two novel polar interactions. One with Q738 of the wild type site and the second with the mutated A877 residue.

  17. 76 FR 45577 - Clinical Investigator Training Course

    Science.gov (United States)

    2011-07-29

    ... that FDA is not responsible for providing access to electrical outlets. SUPPLEMENTARY INFORMATION: I... of clinical investigators with knowledge, experience, and commitment to investigational medicine...'s role in experimental medicine; and Improve the quality of data while enhancing subject...

  18. PRELIMINARY PHYTOCHEMICAL AND HISTOCHEMICAL INVESTIGATION ON KIGELIA PINNATA DC.,

    OpenAIRE

    Dhanasekaran, M.; ABRAHAM.G.C; Mohan, S.

    2014-01-01

    Kigelia pinnata D.C. the mid sized ornamental tree of the Bignoniaceae has been studied by preliminary phytochemical and histochemical analysis. Several local names are availability to this plants based on their country. They are called worsboom in Africa and sauage tree in America. The tree is 25 meters in hight with a dense rounded crown bark grey. Data gathered on solvent extraction and preliminary phytochemical method suggested that the presence of glycosides, flavonoides, tannin and alka...

  19. 77 FR 60440 - Clinical Investigator Training Course

    Science.gov (United States)

    2012-10-03

    ... clinical investigators on issues of greatest importance for successful clinical research. Date and Time... importance for successful clinical research. II. Description of the Training Course A. Purpose The training... and comprised of approximately 26 lectures, each lasting between 30 and ] 45 minutes. The course...

  20. Preliminary investigation of the magnetostratigraphy of the Ringold Formation

    Energy Technology Data Exchange (ETDEWEB)

    Packer, D.R.; Johnston, J.M.

    1979-05-01

    The Ringold Formation consists of lacustrine and fluvial deposits overlying the Columbia River Basalt. The Ringold Formation, because of its thickness, extent, and age, is an excellent unit in which to detect and possibly data the deformation that has occurred since deposition of the basalt. One objective of this study was to investigate the paleomagnetism of the upper Ringold unit exposed at one location in the White Bluffs in enough detail to resolve, with reasonable confidence, the magnetostratigraphy of the rock units sampled. The other objective was to evaluate, in a preliminary manner, the paleomagnetic favorability and magnetostratigraphy of the subsurface Ringold Formation in the Pasco Basin and at selected exposures outside the Pasco Basin. The scope of this study was the collection of 300 paleomagnetic samples, their measurement, and analysis. Samples were collected from the White Bluffs, from core recovered from six drill holes on the Hanford Site, and from two surface exposures outside the Pasco Basin. A total of 294 samples was collected, and 2928 paleomagnetic measurements were performed on these samples. The samples were measured by means of a three-axis super-conducting rock magnetometer having a sensitivity of 10/sup -8/ emu/cm/sup 3/ and were demagnetized progressively in a 400-hertz alternating field (AF). All data were recorded and processed during measurement by an on-line computer.The declination, inclination, and intensity of magnetization of the samples from the various sections are plotted as a function of their stratigraphic position. The directions of the magnetization of the various sections are also plotted as a group on Wulff equal-angle stereonets. 22 figures, 8 tables.

  1. Social support and fires in the workplace: a preliminary investigation.

    Science.gov (United States)

    McKimmie, Blake M; Jimmieson, Nerina L; Mathews, Rebecca; Moffat, Kieren

    2009-01-01

    Workers who experience fire in the workplace are faced with disruption to their work routine, as well as the emotional strain of the fire. In the broader occupational stress literature, researchers have suggested that social support will be most effective at reducing the negative effects of stressors on strain when the type of support matches the type of stressor being experienced (either instrumental or emotional). This study was a preliminary investigation into employee responses to less routine stressors, such as workplace fires, and the role of different sources of social support in predicting coping effectiveness. This study also was a first attempt at considering the influence of the social context (in terms of group identification) on the effectiveness of social support as a predictor of coping effectiveness. Specifically, it was predicted that social support would be more effective when it came from multiple sources within the organization, that it would be especially effective when provided from a group that workers identified more strongly with, and that simply feeling part of a group would improve adjustment. Both quantitative and qualitative data were collected from 33 employees who had recently experienced a significant fire in their workplace. Results suggested that the type of stressors experienced and the type of support were mismatched, but despite this, coping effectiveness was generally moderate to high. There was mixed support for predictions about the effects of social support-no moderating effect of group identification on coping effectiveness was observed for measures of workplace support, although it did moderate the effects of family support on this adjustment indicator.

  2. Clinical investigation program, fiscal year 1991

    Science.gov (United States)

    Schydlower, Manuel

    1992-02-01

    Subject report identifies the research activities conducted at William Beaumont Army Medical Center by investigators who had protocols approved by the Clinical Investigation Committee, the Institutional Review Board, and the Animal Use Committee. This report includes all protocols registered with the Department of Clinical Investigation during FY 1991. All known presentations and publications are also included. The research protocols described were conducted under the provisions of AR 40-38 (Clinical Investigation Program); AR 40-7 (Use of Investigational Drugs in Humans and the Use of Schedule 1 Controlled Substances); AR 70-25 (Usle of Volunteers as Subjects of Research); HSC 40-32 (Management of Clinical Investigation Protocols and Reports); and AR 70-18 (The Use of Animals in DOS programs).

  3. Preliminary investigation of dose for a dedicated mammotomography system

    Science.gov (United States)

    McKinley, Randolph L.; Tornai, Martin P.

    2006-03-01

    We use a previously reported, optimized quasi-monochromatic beam technique together with unique complex acquisition trajectories made possible with a novel, dedicated cone-beam transmission computed mammotomography (CmT) system to investigate effects of low dose imaging of pendant, uncompressed breasts. Investigators have used a guideline of dose for CmT type applications as that used for dual-view mammography (4-6 mGy for average breast size). This dose is somewhat arbitrary, and it may be possible to reduce this significantly without sacrificing image quality using our quasi-monochromatic x-ray beam, 3D complex acquisition orbits, and iterative reconstruction techniques. A low-scatter acrylic resolution phantom in various media, a breast phantom with sponge and oil-filled lesions, and a cadaver breast are used to evaluate the effect of lowered dose on resolution and image artifacts. Complex saddle acquisition trajectories (necessary to overcome cone-beam distortion) are carried out for total exposures of 96, 300, and 600 mAs over 240 projections. These exposures relate approximately to 1/10 th, 1/3 rd, and 2/3 rd of the standard dual view mammography dose for an average sized 50% adipose/glandular breast. Iterative reconstruction uses an OSTR algorithm with 0.125 mm 3 voxels. Image artifacts increased as dose was reduced but did not appear to greatly degrade image quality except at the lowest contrast tested (1% absolute contrast). As expected, noise increased as dose was reduced. However, this did not appear to affect resolution for rods in air (high contrast), nor rods in oil (20% absolute contrast). Resolution was reduced for rods in water (1% absolute contrast) due to increased prevalence of image artifacts as well as increased noise. Breast phantom imaging of soft lesions in a highly glandular breast (6% absolute contrast) clearly yielded the 60uL and all larger volume lesions. Preliminary biological breast tissue results illustrate excellent subjective

  4. Public Relations Ethics and Communitarianism: A Preliminary Investigation.

    Science.gov (United States)

    Leeper, Kathie A.

    1996-01-01

    Presents a preliminary examination of communitarianism and its emphasis on community and responsibility as an ethical base for public relations. Suggests that the emphasis business currently places on quality, social responsibility, and stewardship may fit within a communitarian approach. Argues that a communitarian base to public relations may…

  5. Magnetotelluric investigation across the Agri Valley: preliminary results.

    Science.gov (United States)

    Balasco, Marianna; Romano, Gerardo; Siniscalchi, Agata; Alfredo Stabile, Tony

    2017-04-01

    The Agri Valley is an axial zone of the Southern Apennines thrust belt chain with a strong seismogenic potential where two important energy technologies responsible for inducing/triggering seismicity are active: (1) the disposal at the Costa Molina 2 injection well of the wastewater produced during the exploitation of the biggest onshore oil field in west Europe (27 wells producing more than 80,000 barrels of crude oil per day), managed by the Eni S.p.A., and (2) the water loading and unloading operations in the Pertusillo artificial reservoir. It is recognized the possibility that the fluctuation of the water level inside the reservoir, due to the hydrological cycle for example, produces pressure perturbations at the bottom of reservoir, causing induced seismicity. Furthermore it is even more known the role of fluids in the rupture processes which could cause an increase of pore pressure specially at high rate of injection fluids and/or for the presence of weakening of preexisting faults. With the aim to better characterize and understand the physical processes involved in the observed induced/triggered seismicity, in 2016 a broadband seismic network, covering an area of about 20 km x 20 km nearby the Pertusillo Dam and Costa Molina2 well has been installed in the framework of SIR-MIUR project INSIEME (INduced Seismicity in Italy: Estimation, Monitoring, and sEismic risk mitigation) and a MagnetoTelluric (MT) survey has been performed. The MT investigation consists of 25 soundings aligned along 30 km profile oriented at about N40 direction, orthogonal with the strike of the major and noticeable geological structures and crossing both of the source that may induce/trigger seismicity. In this work, we present the preliminary 2D resistivity model which provides useful deep geophysical information for understanding the geological and structural setting of the Agri Valley. Moreover, the comparison of the resistivity model with the earthquake location as inferred from

  6. 75 FR 57472 - Clinical Investigator Training Course

    Science.gov (United States)

    2010-09-21

    ... outlets. If you need special accommodations due to a disability, please contact Nancy Masiello at least 7 days in advance. SUPPLEMENTARY INFORMATION: Clinical trial investigators play a critical role in the... studies, and chemistry/manufacturing information) that supports initial clinical trials in...

  7. Altered Passive Eruption and Familial Trait: A Preliminary Investigation

    Directory of Open Access Journals (Sweden)

    Roberto Rossi

    2014-01-01

    Full Text Available Altered passive eruption is described as a condition in which the relationship between teeth, alveolar bone, and the soft tissues creates an excessive gingival display and, in turn, in some circumstances, it may reveal a clinical aspect also known as the “gummy smile.” The surgical management of such cases is well understood and has been widely described, with mucogingival and osseous resective procedures being predictable surgical means leading to more balanced aesthetics and proper display of the teeth anatomy. The possible familial trait in case of passive eruption and therefore the possibility of recurrence of the same condition in families of siblings or parents of affected patients have been investigated in this study. 20 patients have been selected and treated in both a private practice and university settings and their immediate family trees were evaluated in order to understand the incidence of the condition. 65% of the treated patients had one or more family members with the same condition leading to seeking further investigation on the possible genetic correlation.

  8. A preliminary experimental investigation into lateral pedestrian-structure interaction

    DEFF Research Database (Denmark)

    Ingólfsson, Einar Thór; Georgakis, Christos; Knudsen, Anders

    2008-01-01

    This paper presents results from a preliminary experimental study on lateral human-structure dynamic interaction on footbridges using an instrumented platform. The platform has a natural frequency within the range of an average pedestrian and consists of a suspended concrete girder. With a length...... of 17 m and weight of 19.6 ton, the platform provides a realistic comparison to an actual footbridge. Based on experiments with single pedestrians walking across the platform at resonance, the fundamental dynamic load factor is determined using only the recorded acceleration signal. Furthermore, tests...

  9. Preliminary Investigations into the Development of Textile Based Temperature Sensor for Healthcare Applications

    Directory of Open Access Journals (Sweden)

    Richard Kennon

    2013-04-01

    Full Text Available Human body temperature is an important sign of physical condition in terms of comfort, heat or cold stresses, and of performance. This paper presents the preliminary investigation into the design, manufacturing and testing of the textile based temperature sensor. This sensing fabric may be employed to measure the temperature of the human body on a continuous basis over extensive periods of time, outside the clinical environment. The sensing fabric was manufactured on an industrial scale flat-bed knitting machine by laying-in the sensing element (in the form of fine metal wire into the double layer knitted structure. The operational principle of the sensing fabric is based on the inherent tendency of metal wire to change in its electrical resistance because of the change in its temperature. An experimental resistance-temperature relationship showed promising validation in comparison with their modeled counterparts.

  10. Summary of preliminary contaminant impacts investigations in the Clinch River Basin, Virginia, using multiple bioassessment techniques

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — In 1992 multiple investigations were performed to collect preliminary information to direct future studies aimed at characterizing contaminant problems in the Clinch...

  11. A preliminary investigation of daily variability of stuttering in adults.

    Science.gov (United States)

    Constantino, Christopher D; Leslie, Paula; Quesal, Robert W; Yaruss, J Scott

    2016-01-01

    Variability in frequency of stuttering has made the results of treatment outcome studies difficult to interpret. Many factors that affect variability have been investigated; yet the typical range of variability experienced by speakers remains unknown. This study examined the day-to-day variability in the percentage of syllables containing stuttered and nonstuttered disfluencies in the speech of six adult speakers in three spontaneous speaking situations and two reading tasks. The frequency of moments stuttering during the tasks were compared within and between speakers and days to document the degree of variability in stuttering frequency and explore whether there were any consistent patterns. The Stuttering Severity Instrument-Fourth Edition (SSI-4) and Overall Assessment of the Speaker's Experience of Stuttering for Adults (OASES-A) were also tested for day-to-day variability. Correlations between frequency, severity, and life impact were made. The primary result of this study was the large range over which frequency of stuttering varied from day to day for the same individual. This variability did not correlate with any measures of stuttering severity but did correlate with life impact as measured by the OASES-A. No global pattern was detected in variability from day to day within or between participants. However, there were significantly more nonstuttered disfluencies present during the spontaneous speaking tasks than during the reading tasks. The day-to-day variability in the life impact of the disorder (OASES-A) was less than the day-to-day variability in observable stuttering behavior (percentage of syllables stuttered and SSI-4). Frequency of stuttering varies significantly from situation to situation and day to day, with observed variability exceeding the degree of change often reported in treatment outcomes studies from before to after treatment. This variability must be accounted for in future clinical and scientific work. Copyright © 2016 Elsevier Inc

  12. Geothermal investigations in Czechoslovakia 1974-1975: preliminary report

    Energy Technology Data Exchange (ETDEWEB)

    Cermak, V. (Geophys. Inst., Prague); Kresl, M.; Lizon, I.; Marusiak, I.; Vesely, I.

    1977-01-01

    New heat flow data collected during 1974 and 1975, as well as the corresponding temperature versus depth profiles for Czechoslovakia are discussed, and a preliminary heat flow map is drafted, based on these data. The heat flow patterns are analyzed on the basis of their relation to the tectonic setting in each instance, including major units such as the Bohemian Massif, the Carpathian Foredeep, and the Western Carpathians. The heat flow is obviously related to the tectonic setting, with increased heat flow corresponding to local elevation of the Mohorovicic discontinuity and tectonic instability. There is a general increase in heat flow from the outer zones of the Carpathian belt toward the inner structural units. A marked increase occurs along a northeast trend across the Carpathian Foredeep. Twenty-four references are provided.

  13. Preliminary Investigation of Sulfur Loading in Hanford LAW Glass

    Energy Technology Data Exchange (ETDEWEB)

    Vienna, John D.; Hrma, Pavel R.; Buchmiller, William C.; Ricklefs, Joel S.

    2004-04-01

    A preliminary estimate was developed for loading limits for high-sulfur low-activity waste (LAW) feeds that will be vitrified into borosilicate glass at the Hanford Site in the waste-cleanup effort. Previous studies reported in the literature were consulted to provide a basis for the estimate. The examination of previous studies led to questions about sulfur loading in Hanford LAW glass, and scoping tests were performed to help answer these questions. These results of these tests indicated that a formulation approach developed by Vienna and colleagues shows promise for maximizing LAW loading in glass. However, there is a clear need for follow-on work. The potential for significantly lowering the amount of LAW glass produced at Hanford (after the initial phase of processing) because of higher sulfur tolerances may outweigh the cost and effort required to perform the necessary testing.

  14. Investigation of Sorption and Diffusion Mechanisms, and Preliminary Economic Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Bhave, Ramesh R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Jubin, Robert Thomas [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Spencer, Barry B. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Nair, Sankar [Georgia Inst. of Technology, Atlanta, GA (United States)

    2017-02-01

    This report describes the synthesis and evaluation of molecular sieve zeolite membranes to separate and concentrate tritiated water (HTO) from dilute HTO-bearing aqueous streams. Several monovalent and divalent cation exchanged silico alumino phosphate (SAPO-34) molecular sieve zeolite membranes were synthesized on disk supports and characterized with gas and vapor permeation measurements. The pervaporation process performance was evaluated for the separation and concentration of tritiated water. Experiments were performed using tritiated water feed solution containing tritium at the high end of the range (1 mCi/mL) anticipated in a nuclear fuel processing system that includes both acid and water streams recycling. The tritium concentration was about 0.1 ppm. The permeate was recovered under vacuum. The HTO/H2O selectivity and separation factor calculated from the measured tritium concentrations ranged from 0.99 to 1.23, and 0.83-0.98, respectively. Although the membrane performance for HTO separation was lower than expected, several encouraging observations including molecular sieving and high vapor permeance are reported. Additionally, several new approaches are proposed, such as tuning the sorption and diffusion properties offered by small pore LTA zeolite materials, and cation exchanged aluminosilicates with high metal loading. It is hypothesized that substantially improved preferential transport of tritium (HTO) resulting in a more concentrated permeate can be achieved. Preliminary economic analysis for the membrane-based process to concentrate tritiated water is also discussed.

  15. Capillary blood glucose screening for gestational diabetes: a preliminary investigation.

    Science.gov (United States)

    Landon, M B; Cembrowski, G S; Gabbe, S G

    1986-10-01

    Home glucose monitoring with the use of reflectance meters is an important adjunct in the care of pregnant women with insulin-dependent diabetes. The accuracy of reflectance meters for the assay of capillary glucose specimens has been well documented. The present preliminary study was undertaken to determine the utility of outpatient screening for gestational diabetes mellitus with the use of a reflectance meter (Accu-Chek, Boehringer Mannheim Co.). One hundred twenty-five patients in our high-risk practice had a standard 50 gm glucose load at 26 to 28 weeks' gestation. Capillary glucose values were measured on site with the Accu-Chek. Venous plasma glucose levels were measured by the central laboratory chemistry analyzer. While the laboratory (x) and meter (y) glucose determinations between the two sets of values were highly correlated (R = 0.89, p less than 0.001), there was a significant difference in their average values (x = 111.74, y = 136.35, p less than 0.0001). With the use of a receiver operator characteristic curve, a meter value of 160 mg/dl was determined as the optimal threshold for performing a 3-hour glucose tolerance test. The sensitivity and specificity with the use of a meter value of 160 mg/dl were 93% and 96%, respectively, for detecting an abnormal screening test in venous plasma (greater than or equal to 135 mg/dl). A total of 32 glucose tolerance tests were performed, with four patients included who had venous values less than 135 mg/dl. All eight patients with gestational diabetes mellitus were correctly identified. These data suggest that a glucose reflectance meter can be used for accurate outpatient screening of gestational diabetes mellitus. The potential advantages of capillary blood glucose screening include both cost and efficiency. Patients with abnormal screening values can be promptly identified and scheduled for a follow-up 3-hour glucose tolerance test.

  16. A Preliminary Investigation of Female Entrepreneurs’ Behavior in Romania

    Directory of Open Access Journals (Sweden)

    Bianca Avram

    2016-06-01

    Full Text Available The aim of this paper is to carry out a preliminary analysis of the Romanian female entrepreneurs’ behavior. In order to reach this aim we studied the specialized literature which tries to define the entrepreneur, the feminine entrepreneur, to identify the women’s motivation to become entrepreneurs, the required skills, as well as the potential similarities and differences between female and male entrepreneurs. In the case study we elaborated in this paper, the percentage of women-entrepreneurs from the total number of entrepreneurs who set up a new business represents the independent variable. We used as dependent variable quantitative variables expressed in percentages which describe the situation of newly founded enterprises one year into their set up (active, inactive and liquidated, the size of the newly founded enterprise (0 employees, 1 to 49 employees, and over 49 employees and the type of employment (employers, full-time employees, part-time employees. The data we used are annual, refer to a period of time ranging from 1995 to 2013, and were gathered by the Romanian National Institute of Statistics. The conclusions show that the percentage of Romanian women-entrepreneurs is in tight link with the percentage of active companies one year into their set up. As regards the size of the company, we noticed that women-entrepreneurs own companies with fewer employees. And when referring to the head-office of the company, we notices that it is not influenced by the increase or decrease of the percentage of Romanian women-entrepreneurs.

  17. Automated Dental Epidemiology System. I. Preliminary Investigation and Literature Review,

    Science.gov (United States)

    1983-03-01

    personnel contacted concerning the inadequacy of DIRS for regional and clinical management. There also was skepticism regarding the prognosis of any...for Prevalence and Incidence of Periodontal Disease. T. Periodontol. 30:51, 1959. 24. WHO. Standardization of Reporting of Dental Diseases and...264, 1982. 58. wirthlin, M. R., Hancock, E. B., Cecil, J. C. and Mandel, E. J. Periodontal Disease Among Naval Recruits. Naval Dental Research Institute

  18. Prevention of postoperative tooth sensitivity: a preliminary clinical trial.

    Science.gov (United States)

    Sobral, M A P; Garone-Netto, N; Luz, M A A C; Santos, A P

    2005-09-01

    The purpose of this study was to evaluate clinically the effects of pre-treatments with a 35% hydroxyethyl metacrylate/5% glutaraldehyde dentine desensitizer (Gluma Desensitizer) and a 2% chlorexidine-based cavity disinfectant (Cav-Clean) on postoperative sensitivity. Three premolar teeth with no pain symptoms were selected from each one of 17 patients, totalling 51 teeth, for which Class II restoration using a composite was indicated. Each one of the three premolar teeth of the same patient was submitted to a different treatment. After acid etching, only a dental adhesive was applied to the first tooth, which served as the control. Gluma Desensitizer dentinal desensitizer was applied to the second premolar tooth prior to applying the dental adhesive. Cav-Clean cavity disinfectant was used on the third premolar tooth before applying the dental adhesive. Only one tooth was restored per session, and all premolar teeth were restored with a condensable composite, according to current restoration technique guidelines. Sensitivity to different stimuli (cold, heat, sweet and dental floss) was assessed on Day 1, Day 4 and Day 7 by questionnaire following restorative procedures. The results of this clinical research showed that, as far as the investigated stimuli and postoperative course are concerned, there was no statistically significant difference in the three different treatments (P>0.05). Postoperative sensitivity resulting from Class II restorations using composite resin cannot be completely eliminated with the prior use of a dentinal desensitizer or a cavity disinfectant. In day-to-day clinical treatment, postoperative sensitivity may possibly be related to the technique employed.

  19. Spirituality and Young Women in Transition: A Preliminary Investigation

    Science.gov (United States)

    Livingston, Kimberly A.; Cummings, Anne L.

    2009-01-01

    This study contributes to the growing body of knowledge about spirituality and life transitions. Through qualitative investigation, 9 young women in professional education programs described their definition of spirituality, their spiritual activities, and how they used their spirituality to cope with life transitions as they prepared to enter the…

  20. Preliminaries to an investigation of reduced product set finance

    NARCIS (Netherlands)

    Bergstra, J.A.; Middelburg, C.A.

    2011-01-01

    Principles of financial product synthesis from a few basic financial products constitute an interesting research topic inspired by Islamic finance. We make an effort to answer general questions that should be answered before starting to investigate the main issues concerning this topic with the form

  1. Preliminaries to an investigation of reduced product set finance

    NARCIS (Netherlands)

    Bergstra, J.A.; Middelburg, C.A.

    2010-01-01

    Principles of financial product synthesis from a few basic financial products constitute an interesting research topic inspired by Islamic finance. We make an effort to answer general questions that should be answered before starting to investigate the main issues concerning this topic with the form

  2. A preliminary investigation into the acquisition of fingerprints on food.

    Science.gov (United States)

    Ferguson, Sarah; Nicholson, Lynsey; Farrugia, Kevin; Bremner, David; Gentles, Dennis

    2013-03-01

    The potential for enhancement and recovery of latent fingerprints on a variety of foodstuffs has been investigated. In general, black magnetic powder and black powder suspensions appear to be the most successful enhancement techniques with a high number of ridge detail-developed prints over a selected time scale. Banana, apple and tomato surfaces showed enhancement of latent prints but potato and egg surfaces proved to be less successful.

  3. Everyday episodic memory in amnestic Mild Cognitive Impairment: a preliminary investigation

    LENUS (Irish Health Repository)

    Irish, Muireann

    2011-08-04

    Abstract Background Decline in episodic memory is one of the hallmark features of Alzheimer\\'s disease (AD) and is also a defining feature of amnestic Mild Cognitive Impairment (MCI), which is posited as a potential prodrome of AD. While deficits in episodic memory are well documented in MCI, the nature of this impairment remains relatively under-researched, particularly for those domains with direct relevance and meaning for the patient\\'s daily life. In order to fully explore the impact of disruption to the episodic memory system on everyday memory in MCI, we examined participants\\' episodic memory capacity using a battery of experimental tasks with real-world relevance. We investigated episodic acquisition and delayed recall (story-memory), associative memory (face-name pairings), spatial memory (route learning and recall), and memory for everyday mundane events in 16 amnestic MCI and 18 control participants. Furthermore, we followed MCI participants longitudinally to gain preliminary evidence regarding the possible predictive efficacy of these real-world episodic memory tasks for subsequent conversion to AD. Results The most discriminating tests at baseline were measures of acquisition, delayed recall, and associative memory, followed by everyday memory, and spatial memory tasks, with MCI patients scoring significantly lower than controls. At follow-up (mean time elapsed: 22.4 months), 6 MCI cases had progressed to clinically probable AD. Exploratory logistic regression analyses revealed that delayed associative memory performance at baseline was a potential predictor of subsequent conversion to AD. Conclusions As a preliminary study, our findings suggest that simple associative memory paradigms with real-world relevance represent an important line of enquiry in future longitudinal studies charting MCI progression over time.

  4. Preliminary investigation of radiatively driven convection in marine stratocumulus clouds

    Energy Technology Data Exchange (ETDEWEB)

    Norris, P. [Univ. of California, San Diego, CA (United States)

    1995-09-01

    Marine stratocumulus play an important yet still poorly modeled role in the climate system. These clouds cool the planet, having a large albedo, but little infrared effect. A fundamental question is whether such clouds will exist at a given time and location. Stratocumulus is often formed at higher latitudes as stratus and advected equatorward until it breaks up. Possible mechanisms for cloud breakup include strong subsidence, cloud top entrainment instability (CTEI), drizzle, solar heating and resultant boundary layer decoupling, and surface forcing. The Atlantic Stratocumulus Transition Experiment (ASTEX) was conducted to investigate these potential cloud breakup mechanisms. 5 refs., 3 figs.

  5. Preliminary experimental investigation of boundary layer in decelerating flow

    Directory of Open Access Journals (Sweden)

    Příhoda J.

    2013-04-01

    Full Text Available Investigations of characteristics of turbulence inside boundary layer under decelerating flow were studied by means of constant temperature anemometer. The decelerating flow was simulated in the closed circuit wind tunnel 0.9 m × 0.5 m at IT AS CR. The free stream turbulence was either natural o risen up by square mesh plane grid. The details of experimental settings and measurement procedures of the instantaneous longitudinal velocity component are described and the distributions of intensity, skewness and kurtosis of turbulent fluctuations are discussed in the contribution.

  6. A preliminary investigation: the impact of microscopic condenser on depth of field in cytogenetic imaging

    Science.gov (United States)

    Ren, Liqiang; Qiu, Yuchen; Li, Zheng; Li, Yuhua; Zheng, Bin; Li, Shibo; Chen, Wei R.; Liu, Hong

    2013-02-01

    As one of the important components of optical microscopes, the condenser has a considerable impact on system performance, especially on the depth of field (DOF). DOF is a critical technical feature in cytogenetic imaging that may affect the efficiency and accuracy of clinical diagnosis. The purpose of this study is to investigate the influence of microscopic condenser on DOF using a prototype of transmitted optical microscope, based on objective and subjective evaluations. After the description of the relationship between condenser and objective lens and the theoretical analysis of the condenser impact on system numerical aperture and DOF, a standard resolution pattern and several cytogenetic samples are adopted to assess the condenser impact on DOF, respectively. The experimental results of these objective and subjective evaluations are in agreement with the theoretical analysis and show that, under the specific intermediate range of condenser numerical aperture ( NAcond ), the DOF value decreases with the increase of NAcond . Although the above qualitative results are obtained under the experimental conditions with a specific prototype system, the methods presented in this preliminary investigation could offer useful guidelines for optimizing operational parameters in cytogenetic imaging.

  7. Trained Quantity Abilities in Horses (Equus caballus: A Preliminary Investigation

    Directory of Open Access Journals (Sweden)

    Maria Elena Miletto Petrazzini

    2014-07-01

    Full Text Available Once believed to be a human prerogative, the capacity to discriminate between quantities now has also been reported in several vertebrates. To date, only two studies investigated numerical abilities in horses (Equus caballus but reported contrasting data. To assess whether horses can be trained to discriminate between quantities, I have set up a new experimental protocol using operant conditioning. One adult female was trained to discriminate between 1 and 4 (Test 1 in three different conditions: non-controlled continuous variables (numerical and continuous quantities that co-vary with number are simultaneously available, 50% controlled continuous variables (intermediate condition, and 100% controlled continuous variables (only numerical information available. The subject learned the discrimination in all conditions, showing the capacity to process numerical information. When presented with a higher numerical ratio (2 vs. 4, Test 2, the subject still discriminated between the quantities but its performance was statistically significant only in the non-controlled condition, suggesting that the subject used multiple cues in presence of a more difficult discrimination. On the whole, the results here reported encourage the use of this experimental protocol as a valid tool to investigate the capacity to process numerical and continuous quantities in horses in future research.

  8. A clinical and investigational study of donovanosis

    Directory of Open Access Journals (Sweden)

    Veeranna S

    2003-03-01

    Full Text Available A clinical and investigational study of 25 cases of Donovanosis was undertaken. The incidence was found to be 1.53% of all STD cases and 2.9% of GUD. M:F ratio was 2.12:1. Incidence was more in unmarried people. Fleshy exuberant type was seen in 88% of cases. Two patients (8% had extragenital ulcers. Donovan bodies were found in 88%. Pseudo elephantiasis was seen in 8 patients. Biopsy was done in 8 cases and showed ocanthosis, plasma cell infiltration and pseudo epitheliomatous hyperplasia. One patient developed squamous cell carcinoma of vulva.

  9. Preliminary investigation on the coastal rogue waves of Jiangsu, China

    Directory of Open Access Journals (Sweden)

    Y. Wang

    2013-11-01

    Full Text Available As an eye-catching issue, rogue waves have been undergoing different stages from theory to practice gradually, whose occurrence always brings about severe threat to not only ships and sailors but also coastal structural integrity. Due to the scarce wave observations in coastal zone and meager study in Mainland China, the discussion specifically aimed at observed coastal rogue waves in China was at elementary stage. Based on the measured data from Xiangshui station of Jiangsu, China, the characteristics including occurrence probability and nonlinearity are investigated, which is a supplement to the previous research works. Surprisingly, the outcomes tend to refute rather than confirming some of the traditional conceptions about rogue waves. A new concept for the classification of coastal rogue waves is proposed afterwards.

  10. Preliminary results of fisheries investigation associated with Skylab-3

    Science.gov (United States)

    Savastano, K.; Pastula, E., Jr.; Woods, G.; Faller, K.

    1974-01-01

    The purpose of the 15-month investigation now in the analysis phase is to establish the feasibility of utilizing remotely sensed data acquired from aircraft and satellite platforms to provide information concerning the distribution and abundance of oceanic gamefish. Data from the test area, jointly acquired by private and professional fishermen and NASA and NOAA/NMFS elements, in the northeastern Gulf of Mexico has made possible the identification of significant environmental parameters for white marlin. Predictive models based on catch data and surface truth information have been developed and have demonstrated potential for reducing search significantly by identifying areas which have a high probability of being productive. Three of the parameters utilized by the model, chlorophyll-a, sea surface temperature and turbidity have been inferred from aircraft sensor data.

  11. The effect of stuttering on communication: a preliminary investigation.

    Science.gov (United States)

    Spencer, Elizabeth; Packman, Ann; Onslow, Mark; Ferguson, Alison

    2009-07-01

    This paper describes a study in which Systemic Functional Linguistics was applied to describe how people who stutter use language. The aim of the study was to determine and describe any differences in language use between a group of 10 adults who stutter and 10 matched normally-fluent speakers. In addition to formal linguistic analyses, analyses drawn from Systemic Functional Linguistics were used to further investigate the expression of both syntactic and semantic complexity. The findings from this study replicated previous findings of Packman et al. in which they found that the language used by people who stutter was significantly less complex than the control group. Another major finding was that adults who stuttered used the linguistic resource of modality significantly less than the normally-fluent matched peers. The implications these strategies have on communication and social participation will be discussed.

  12. Preliminary investigation of trapped particle instabilities in EBT

    Energy Technology Data Exchange (ETDEWEB)

    Batchelor, D.B.; Hedrick, C.L.

    1978-05-01

    An investigation is presented of the role which trapped particles might play in the drift wave stability of ELMO Bumpy Torus (EBT). The model adopted consists of a bounce-averaged drift kinetic equation with a Krook collision operator. Care has been taken to model, at least in an elementary way, the features which distinguish the physics of EBT from that of tokamaks, namely the large magnitude and velocity space dependence of the poloidal drift frequency ..cap omega.., the relatively small collisionality ..nu../..cap omega.., the enhancement of ..nu../sub eff/ for passing particles, and the closed nature of the field lines. Instabilities are found which have a somewhat dissipative character, however the precessional drift is found to be a significant stabilizing influence. In most cases, the modes are completely stabilized when ..omega../sub *//l..cap omega.. approximately equal to 1 for normal gradients. For reversed gradients (..omega../sub *//l..cap omega.. < 0), stability is greatly enhanced.

  13. Preliminary investigation on concentrating of acetol from wood vinegar

    Energy Technology Data Exchange (ETDEWEB)

    Wang Ze, E-mail: windw100@sohu.co [State Key Laboratory of Multi-Phase Complex System, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190 (China); Lin Weigang [State Key Laboratory of Multi-Phase Complex System, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190 (China); Song Wenli, E-mail: wlsong@home.ipe.ac.c [State Key Laboratory of Multi-Phase Complex System, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190 (China); Yao Jianzhong [State Key Laboratory of Multi-Phase Complex System, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190 (China)

    2010-02-15

    Acetol, as one of the components in biomass pyrolysis liquid, is a high value added compound for medicine synthesis. Benefit may be obtained if acetol can be extracted from the pyrolysis liquid, while the instability of acetol makes the concentrating difficult. In this paper, the concentrating of acetol from wood vinegar is preliminarily investigated, and the conditions of distillation, solvent extraction, and Na{sub 2}CO{sub 3} effect on the concentrating result are discussed. Herein the content of acetol can be concentrated from below 4% in the raw wood vinegar to above 60%, and the number of main components reduce from over 20 to 5, while the yield of acetol is still rather low. It was found that in the organic solution distillation process, acetol can be easily concentrated from 1% to above 40%, while a further distillation of the concentrated acetol system was rather hard. The conversion of acetol in the distillation process was probably an important cause to the low yield of acetol, and a lower distillation temperature was advantageous for the concentrating of acetol.

  14. Preliminary investigations on high energy electron beam tomography

    Energy Technology Data Exchange (ETDEWEB)

    Baertling, Yves; Hoppe, Dietrich; Hampel, Uwe

    2010-12-15

    In computed tomography (CT) cross-sectional images of the attenuation distribution within a slice are created by scanning radiographic projections of an object with a rotating X-ray source detector compound and subsequent reconstruction of the images from these projection data on a computer. CT can be made very fast by employing a scanned electron beam instead of a mechanically moving X-ray source. Now this principle was extended towards high-energy electron beam tomography with an electrostatic accelerator. Therefore a dedicated experimental campaign was planned and carried out at the Budker Institute of Nuclear Physics (BINP), Novosibirsk. There we investigated the capabilities of BINP's accelerators as an electron beam generating and scanning unit of a potential high-energy electron beam tomography device. The setup based on a 1 MeV ELV-6 (BINP) electron accelerator and a single detector. Besides tomographic measurements with different phantoms, further experiments were carried out concerning the focal spot size and repeat accuracy of the electron beam as well as the detector's response time and signal to noise ratio. (orig.)

  15. Preliminary Investigation of the Process Capabilities of Hydroforging

    Directory of Open Access Journals (Sweden)

    Bandar Alzahrani

    2016-01-01

    Full Text Available Hydroforging is a hybrid forming operation whereby a thick tube is formed to a desired geometry by combining forging and hydroforming principles. Through this process hollow structures with high strength-to-weight ratio can be produced for applications in power transmission systems and other structural components that demands high strength-to-weight ratio. In this process, a thick tube is deformed by pressurized fluid contained within the tube using a multi-purpose punch assembly, which is also used to feed tube material into the die cavity. Fluid pressure inside the thick tube is developed by volume change governed by the movement of the punch assembly. In contrast to the conventional tube hydroforming (THF, the hydroforging process presented in this study does not require external supply of pressurized fluid to the deforming tube. To investigate the capability of hydroforging process, an experimental setup was developed and used to hydroforge various geometries. These geometries included hollow flanged vessels, hexagonal flanged parts, and hollow bevel and spur gears.

  16. Trypophobia: an investigation of clinical features.

    Science.gov (United States)

    Vlok-Barnard, Michelle; Stein, Dan J

    2017-04-13

    Trypophobia refers to the fear of, or aversion to, clusters of holes. We assessed clinical features of trypophobia and investigated whether it most resembled a specific phobia or obsessive-compulsive disorder. An online survey was conducted to gather information on sociodemographic variables, course and duration, severity, associated features, comorbid psychiatric diagnoses, and levels of psychological distress and impairment in individuals with trypophobia. The survey also explored whether such individuals experienced more fear or disgust, and whether symptoms showed more resemblance to a specific phobia or to obsessive-compulsive disorder. Associations of symptom severity and duration with degree of impairment were investigated. One hundred and ninety-five individuals completed the questionnaire. Symptoms were chronic and persistent. The most common associated comorbidities were major depressive disorder and generalized anxiety disorder. Trypophobia was associated with significant psychological distress and impairment. The majority of individuals experienced disgust rather than fear when confronted with clusters of holes, but were more likely to meet DSM-5 criteria for specific phobia than for obsessive-compulsive disorder. Symptom severity and duration were associated with functional impairment. Given that individuals with trypophobia suffer clinically significant morbidity and comorbidity, this condition deserves further attention from clinicians and researchers.

  17. A preliminary study of material homogeneity for size effect investigations

    Energy Technology Data Exchange (ETDEWEB)

    Krompholz, K.; Kamber, J.; Kalkhof, D.

    1999-06-01

    The forged material 20 MnMoNi 55, material number 1.6310 (heat number 69906) with a heat treatment of 900 {sup o}C, water quenched, 730 {sup o}C, air cooled, was subjected to an intensive quality control consisting of chemical analysis, metallography, hardness tests, tensile tests, and impact tests. Six plates of the material were investigated, and all specimens were taken from a diagonal of each plate in three positions, outer margins and the centre of the plates. The quality control exhibits the following results: (1) The material fulfill the material specification in all respects. (2) This material is a fine grained homogeneous ferritic material of bainitic structure; neither from the chemical analysis, metallography, nor from hardness tests influences from the position of the specimens taken from the plates could be derived. (3) The tensile tests clearly revealed position dependent material properties. With the exception of one plate, one of the selected positions exhibits no natural yield strength, higher rupture strength, and lower elongation to fracture compared with the other two positions at 293 K and 573 K. (4) Many of the data obtained from the impact tests at room temperature were larger than the capacity of the impact machine, i.e. 225 Joule; the experimental condition was changed from tests at 573 K to tests at 253 K to obtain data from the transition region. The main conclusions drawn for the size effect experiments where that all the tensile test results for different specimen sizes have to be discussed with respect of the specimen positions within the plates, and that for all bend bar as well as impact experiments with different specimen sizes the notch depth to specimen width ratio a/w has to be changed from a/w = 0.2 to a/w = 0.3 to get reasonable results within the frame of the available test equipment. (author)

  18. A Preliminary Investigation into the Information Sharing Behavior of Social Media Users after a Natural Disaster

    Science.gov (United States)

    Maruyama, Yukiko

    2016-01-01

    The paper provides the results of a preliminary investigation into the information sharing behavior of social media users after a natural disaster. The results indicate that users shared information that they thought victims would find useful. On the other hand, they reported that they usually do not or never share information considered useful to…

  19. Using Web-Based Homework to Teach Principles of Microeconomics: A Preliminary Investigation

    Science.gov (United States)

    Mitchell, Jeannette C.; Mitchell, Johanna E.

    2017-01-01

    This study evaluates an interactive web-based homework designed to increase student understanding in a principles of microeconomics course. Employing concepts from Action Research, the preliminary investigation was undertaken based on assumptions about the efficacy of online educational resources. Do students who do well on online homework improve…

  20. A Preliminary Investigation of Factors Affecting Employment Motivation in People with Intellectual Disabilities

    Science.gov (United States)

    Andrews, Abbye; Rose, John L.

    2010-01-01

    Relatively small numbers of people with intellectual disabilities (ID) are engaging in paid employment and those who are tend to be working only part-time. This preliminary study addressed the question of what factors motivate people with ID to work. The issue was investigated in a sample of 10 young work-age adults attending supported learning…

  1. A Quantitative Approach to Investigating Spanish HL Speakers' Characteristics and Motivation: A Preliminary Study

    Science.gov (United States)

    Yanguas, Inigo

    2010-01-01

    The present preliminary study empirically investigated Spanish heritage language (HL) speakers in Spanish for native speakers (SNS) college courses. It focused on their attitudes and motivation to improve their HL and on their varying linguistic competences in that language. A well-established second language acquisition (SLA) motivational model…

  2. Efficacy of Attention Regulation in Preschool-Age Children Who Stutter: A Preliminary Investigation

    Science.gov (United States)

    Johnson, Kia N.; Conture, Edward G.; Walden, Tedra A.

    2012-01-01

    Purpose: This preliminary investigation assessed the attentional processes of preschool-age children who do (CWS) and do not stutter (CWNS) during Traditional cueing and Affect cueing tasks. Method: Participants consisted of 12 3- to 5-year-old CWS and the same number of CWNS (all boys). Both talker groups participated in two tasks of shifting and…

  3. A preliminary investigation of fine sediment dynamics in Cumbarjua canal, Goa

    Digital Repository Service at National Institute of Oceanography (India)

    Mehta, A.J.; Nayak, B.U.; Hayter, E.J.

    A preliminary field investigation was carried out in a 10 km reach of Cumbarjua Canal, Goa, India, where the sediment is in the fine size range, and the flow is primarily tide-induced. Results based on observations made during February, 1980...

  4. [Hyperandrogenism: clinical aspects, investigation and treatment].

    Science.gov (United States)

    Beckers, A; Parotte, M C; Gaspard, U; Khalife, A

    1999-04-01

    Androgen excess (AE) is one of the most common endocrine disorders, affecting 10% of adult women before the menopause. The clinical picture varies widely depending on the etiology of AE. Most of these women are suffering from hirsutism, acne, menstrual disturbances, anovulation and obesity. Virilization is unusual, except in patients with ovary or adrenal cancer. Polycystic ovary syndrome (PCOS) and idiopathic hirsutism (IH) are the most frequent causes of androgen excess, accounting for more than 90% of the cases. The pathogenesis of PCOS is still an unresolved problem. A hereditary predisposition has been suggested. Enzymatic deficiency is a less frequent cause of AE, the most common deficiency being the non classic 21-OH deficiency (NCAH). AE has been implicated as a side effect of many drugs. Ovary and adrenal tumours are unusual, however, they must be considered especially in case of severe hirsutism or virilization. Complementary investigations are selected based on the result of clinical examination. Pharmacologic therapy, usually with anti-androgens, is the most widely used treatment for PCOS, IH and NCAH. Surgical therapy should be considered only when there is a particular indication such as Cushing's syndrome, ovary or adrenal tumours.

  5. In situ photoimmunotherapy for melanoma: preliminary clinical results

    Science.gov (United States)

    Naylor, Mark F.; Nordquist, Robert E.; Teauge, T. Kent; Perry, Lisa A.; Chen, Wei R.

    2006-02-01

    Although melanoma accounts for only 4% of skin cancer cases, it causes 79% of all skin cancer deaths. Patients with metastatic melanoma have a poor prognosis, and long term survival is only about 5% [1, 2]. Conventional therapies such as surgery and radiation therapy usually do not cure stage III or stage IV melanoma, while traditional chemotherapy is primarily palliative. Over the last decade we have been developing new methods for treating solid tumors like melanoma, first in animal models and now in humans. We present here preliminary results from a new technique that utilizes a combination of laser stimulation and drug therapy to stimulate brisk immunological responses in cases of advanced melanoma with cutaneous metastases. A high-power, near-infrared diode laser (805 nm) is used to kill tumors in situ and a topical toll-like receptor agonist (imiquimod cream, 5%) is used to intensify the resulting immunological response. This is essentially an in situ, tumor vaccine approach to treating solid tumors.

  6. Sesame seed allergy: Clinical manifestations and laboratory investigations

    Directory of Open Access Journals (Sweden)

    Fazlollahi MR.

    2007-10-01

    Full Text Available Background: Plant-origin foods are among the most important sources of food allergic reactions. An increase in the incidence of sesame seed allergy among children and adults has been reported in recent years. The aim of this preliminary study was to investigate the prevalence, importance and clinical manifestations of sesame allergy among Iranian patients.Methods: In a cross-sectional survey, 250 patients with suspected IgE-mediated food allergies completed a questionnaire and underwent skin prick tests with sesame extract as well as cross-reacting foods (walnut, soya and peanut. Total IgE and sesame-specific IgE levels were measured. Patients with positive skin test reactions and/or IgE specific for sesame without clinical symptoms were considered sensitive to sesame. The patients who also had clinical symptoms with sesame consumption were diagnosed as allergic to sesame.Results: Of the 250 patients enrolled in this study, 129 were male and 121 female, with a mean age of 11.7 years. The most common food allergens were cow's milk, egg, curry, tomato and sesame. Sesame sensitivity was found in 35 patients (14.1%. Only five patients (2% had sesame allergy. Sesame-sensitive patients had a significantly higher frequency of positive prick test to cross-reacting foods when compared to non-sensitized patients (p=0.00. The type of symptom was independent of gender and age of the patients, but urticaria and dermatitis-eczema were significantly more frequent in sensitized patients (p=0.008.Conclusions: This is the first study addressing the prevalence of sesame seed allergy in Iranian population. We found sesame to be a common and important cause of food allergy. The panel of foods recommended for use in diagnostic allergy tests should be adjusted.

  7. Preliminary Clinical Study of Intra-vas Device

    Institute of Scientific and Technical Information of China (English)

    吴伟雄; 袁石锦; 陈振文; 谷翊群; 李世勤

    1994-01-01

    Fifty-one volunteers with implanted intravas device (IVD ) in comparison with 40 volunteers undergone no-scalpel vasectomy have been recruited for 1 to 3 years clinical follow-up study, The results demonstrate that efficacy rates of contraception in both the IVD group and the vasectomy group are 100%, Sixteen out of thirty - one volunteers (51.6% ) in the IVD group were found to have glucosidase activity in their seminal plasma 1 to 3 years after the operation. Only 12 subjects in the IVD

  8. Preliminary Investigations on the Distribution of Leptospira Serovars in Domestic Animals in North-west Morocco.

    Science.gov (United States)

    Benkirane, A; Noury, S; Hartskeerl, R A; Goris, M G A; Ahmed, A; Nally, J E

    2016-04-01

    Leptospirosis is a neglected zoonosis of global importance with a complex epidemiology that affects humans, domestic and wild mammals. However, due to the diversity of clinical signs and difficulties of establishing a confirmatory laboratory diagnosis, the disease remains poorly investigated, particularly in the developing world. In Morocco, a descriptive study of the seroprevalence of Leptospira infection in animals has never been undertaken. To fill this gap, the current study was conducted on a subset of animals in north-west Morocco as a preliminary step towards understanding the epidemiological patterns of animal leptospirosis in the country. The study was conducted on 289 serum samples collected between January and April 2012 from dogs, cattle, sheep, goats and donkeys in the areas of Rabat-Temara, Sidi Kacem and Oulmes. All serum samples were tested by the MAT with 14 reference strains of the most prevalent pathogenic serovars of Leptospira and two serovars of non-pathogenic Leptospira. The overall seroprevalence of Leptospira in cattle, sheep, goats, dogs and donkeys was 15%, 18%, 20%, 21% and 20%, respectively. The most prevalent serogroups found in each species were Ballum, Sejroe, and Australis in cattle, Ballum, Australis and Sejroe in sheep, Australis and Ballum in goats, Javanica and Australis in donkey and Australis, Ballum and Canicola in dogs. Of all the serogroups tested in this study, Icterohaemorrhagiae, the only serogroup which has been previously reported in humans in Morocco, was rarely reactive. The majority of reactive sera were collected from low land areas. A large number of sera samples classified as seronegative when tested against pathogenic leptospires were positive when tested against non-pathogenic leptospires; this is suggestive of possible novel, as yet unclassified, Leptospira serovars in Morocco. Eleven of thirteen sheep urine samples were positive by real-time PCR confirming their role as Leptospira carriers in Morocco.

  9. [Clinical diagnosis and standardized evaluation of borderline personality: preliminary report].

    Science.gov (United States)

    Chaine, F; Guelfi, J D; Monier, C; Brun, A; Seunevel, F

    1995-01-01

    A sample of 36 patients considered by French clinicians as suffering from a borderline personality disorder was evaluated using the International Personality Disorder Examination, the Diagnostic Interview for Borderline-Revised, and the Minnesota Multiphasic Personality Inventory. First, global descriptive analysis of the sample elicited the socio-demographic and standard clinical characteristics of the borderline individuals. After diagnostic evaluation, the sample appeared to be quite homogeneous with 25 of the 36 patients evaluated (69.5%) being defined as borderline by two of the three diagnostic systems: ICD 10, DSM III-R and Gunderson (15/36 = 41.5% of patients were defined as borderline by all three systems). It is the types of BL personality co-diagnoses which differentiated the BL subjects in the sample from those classically described in the international literature, since the most frequent personalities were the Dependent and Avoiding ones, not the Antisocial, Histrionic, Narcissistic or Schizotypic personalities of the DSM III-R. ICD 10 elicited the same significant prevalence of Anxious and Dependent personalities. Lastly, the patients diagnosed as borderline both by clinicians and by all diagnostic systems (forming the sample "core") were compared with the rest of the sample with regard to socio-demographic, clinical and diagnostic characteristics. A few hypotheses are proposed on the type of variables that may permit to discriminate between these two types of patients.

  10. Preliminary Assessment/Site Investigation: Tooele Army Depot, Utah. Volume 2. South Area

    Science.gov (United States)

    1988-12-29

    Classification) Preliminary Assessment/Site Investigation, Toefle Army Depot., Utah; Volume ’fl-South Area Q2 PERSONAL AUTHOR(S) Andris Lapins CPG, Li 3a...Regulations CERCLA Comprehensive Environmental Response, Compensation and Liability Act CES Civil Engineering Squadron CGW Chemistry Groundwater File CRL...area around s rEAD . 2-12 Low humidity is a characteristic of the valley climate and visibility is generally good. During winter months, however, storm

  11. Sublingual buprenorphine used postoperatively: clinical observations and preliminary pharmacokinetic analysis.

    OpenAIRE

    Bullingham, R E; McQuay, H. J.; Dwyer, D.; Allen, M C; Moore, R A

    1981-01-01

    1 Buprenorphine is a long-acting opiate analgesic. This study was designed to investigate the pharmacokinetics of this drug when given by the sublingual route to ten postoperative patients. Plasma levels of buprenorphine were measured by a specific radioimmunoassay. 2 Plasma levels of the drug following sublingual administration of 0.4 mg showed an apparent delay in absorption and then rose slowly to reach low but significant levels by 3 h. There was considerable variation in the time at whic...

  12. Self-Reported Neuropathic Pain Characteristics of Women With Provoked Vulvar Pain: A Preliminary Investigation.

    Science.gov (United States)

    Dargie, Emma; Gilron, Ian; Pukall, Caroline F

    2017-04-01

    Provoked vestibulodynia (PVD) is a common chronic genital pain condition affecting approximately 12% of premenopausal women. Although parallels have been drawn between PVD and neuropathic pain (NP), no studies have examined self-reported NP characteristics in PVD. To explore pain symptoms that resemble NP reported by those with PVD and compare responses with those with an established NP condition. Women with provoked vulvar pain (PVP; n = 65) completed online questionnaires designed to assess characteristics of NP. Responses were compared with those of women with postherpetic neuralgia (PHN; n = 30). In addition to a range of descriptive questions, participants completed the McGill Pain Questionnaire, the Self-Complete Leeds Assessment of Neuropathic Signs and Symptoms (S-LANSS), the Neuropathic Pain Symptom Inventory (NPSI), and the Pain Quality Assessment Scale (PQAS). PVP exhibits some neuropathic characteristics, typically evoked pain (as opposed to the more constant pain of PHN) indicative of allodynia and hyperalgesia. Specifically, women with PVP scored, on average, higher than the NP cutoff on the S-LANSS, and there were no significant differences between women with PVP and those with PHN on some NPSI subscales. However, women with PHN reported more NP symptoms on the PQAS, S-LANSS, and other NPSI subscales. Validated NP questionnaires could be of particular use for health care professionals who need a more efficient way to assess symptoms of patients with PVP and should be included in future studies investigating the mechanisms and treatment of this pain. This study takes a unique approach to the examination of PVP by using multiple validated NP measures to compare pain characteristics with those of a group of participants with PHN, an established NP condition. However, it is limited by self-reported data not confirmed with clinical examination, small size of the PHN group, and the severity of the pain experienced in the PVP group. Women with PVP report

  13. The Preliminary Clinical Observation of Array Multifocal lntraocular Lens Implantation

    Institute of Scientific and Technical Information of China (English)

    Zhende Lin; Bo Feng; Yizhi Liu; Bing Cheng

    2001-01-01

    Purpose: To evaluate the clinical effects of implantation of Array multifocal intraocular lenses. Methods: Thirty-one cases (37 eyes) of cataract patients, including 15 males( 19 eyes)and 16 females( 18 eyes), were involved in this study. All patients underwent standard phacoemulsification with Array multifocal intraocular lens implantation. The complications during operation, postoperative distant visual acuity, near visual acuity,corneal curvature and visual symptoms were observed. Results: the mean value of best postoperative visual acuity was recorded as follows:uncorrected distant visual acuity was 0.8, the best-corrected distant visual acuity was 0.9, uncorrected near visual acuity was 0.5, near visual acuity with distant-corrected was 0.6, the best-corrected near visual acuity wss 0.9. The astigmatism of cornea was less than 1.5 D pre-operatively and post-operatively. One patient complained of glare. Conclusion: Array multifocal intraocular lens can provide good distant and near visual acuity. With observation of more cases and follow-up of longer time, we can draw a further conclusion. Eye Science 2001; 17: 57 ~ 60.

  14. PROCEDURAL INDEPENDENCE OF THE INVESTIGATOR AND JUDICIAL REVIEW OF PRELIMINARY INVESTIGATION

    Directory of Open Access Journals (Sweden)

    Betsukhov A. Z.

    2014-11-01

    Full Text Available Judicial review is a necessary and sufficient guarantee of the rights and legitimate interests of participants in criminal proceedings. The only judicial control over the investigation of crimes will expand unreasonably narrowed the boundaries of procedural autonomy and independence of the investigator, will enhance the efficiency, agility pre-trial proceedings. These and other problems were considered by the author from the perspective of theory and practice, as well as in the aggregate of rules of the code of criminal procedure regulating the activities of the investigator

  15. Preliminary Investigation of Zircaloy-4 as a Research Reactor Cladding Material

    Energy Technology Data Exchange (ETDEWEB)

    Brian K Castle

    2012-05-01

    As part of a scoping study for the ATR fuel conversion project, an initial comparison of the material properties of Zircaloy-4 and Aluminum-6061 (T6 and O-temper) is performed to provide a preliminary evaluation of Zircaloy-4 for possible inclusion as a candidate cladding material for ATR fuel elements. The current fuel design for the ATR uses Aluminum 6061 (T6 and O temper) as a cladding and structural material in the fuel element and to date, no fuel failures have been reported. Based on this successful and longstanding operating history, Zircaloy-4 properties will be evaluated against the material properties for aluminum-6061. The preliminary investigation will focus on a comparison of density, oxidation rates, water chemistry requirements, mechanical properties, thermal properties, and neutronic properties.

  16. 76 FR 20575 - Disqualification of a Clinical Investigator

    Science.gov (United States)

    2011-04-13

    ...., drugs) later conducted a clinical investigation studying a different type of test article (e.g., devices... article or conduct any clinical investigation that supports an application for a research or marketing... test articles''; ``continuation of the investigation'' to ``continuation of any investigation'';...

  17. Clinical Investigation Program. Annual Research Progress Report.

    Science.gov (United States)

    1980-09-30

    Stereoscope 79/118 $6149.00 Ion Generator 78/116 $5000.00 Poultry Cages 79/301 $2929.00 Microtome/Cryostat 79/304 $5494.72 Tissue Embedder 79/300... Mycology : Assessment of bacteriologic and seroligic parameters of clinically-important mycoses normal and immunologic comprised host. Presented: American

  18. Clinical Investigation Program, Fiscal Year 1991

    Science.gov (United States)

    1992-02-03

    Clinic at WBAMC with a complaint of sore throat ’ who receive a throat culture will automatically be Included in the study., It will be conducted over...intubate 2 cats employing a laryngoscope and endotracheal tube. Animals will be anesthetized with ketamine HCL (22 mg/kg, given intramuscularly), with...atropine (0.04 mg/kg, subcutaneously). Up to 2 additional half-doses (11 mg/kg) of ketamine may be given if needed. Pre- anesthesia with tranquilizer

  19. Clinical features of dysthymia and age: a clinical investigation.

    Science.gov (United States)

    Bellino, S; Patria, L; Ziero, S; Rocca, G; Bogetto, F

    2001-09-20

    A few authors have described the clinical picture of dysthymia in groups of elderly patients and pointed out differences from literature reports of dysthymia in younger adults. The present study, an attempt to analyze age effects on clinical characteristics of dysthymia throughout a lifetime, was performed in a sample of 106 patients, all aged > or =18 years, who were diagnosed according to DSM-IV. The patients were evaluated using: (1) a semistructured interview to assess clinical features, family history and previous treatments; (2) the Hamilton Depression Rating Scale; (3) the Interview for Recent Life Events; and (4) the Structured Clinical Interview for DSM-IV Disorders. Statistical analysis with stepwise logistic regression revealed that age was positively related to concomitant medical illnesses and to the total score of recent life events, but negatively related to the presence of avoidant or dependent personality disorders. The data suggested different etiologic pathways in older and younger patients. Dysthymia appeared to be associated in younger adults with abnormalities of personality; in the elderly, with a history of health problems and life losses.

  20. Breast ultrasound tomography with two parallel transducer arrays: preliminary clinical results

    Science.gov (United States)

    Huang, Lianjie; Shin, Junseob; Chen, Ting; Lin, Youzuo; Intrator, Miranda; Hanson, Kenneth; Epstein, Katherine; Sandoval, Daniel; Williamson, Michael

    2015-03-01

    Ultrasound tomography has great potential to provide quantitative estimations of physical properties of breast tumors for accurate characterization of breast cancer. We design and manufacture a new synthetic-aperture breast ultrasound tomography system with two parallel transducer arrays. The distance of these two transducer arrays is adjustable for scanning breasts with different sizes. The ultrasound transducer arrays are translated vertically to scan the entire breast slice by slice and acquires ultrasound transmission and reflection data for whole-breast ultrasound imaging and tomographic reconstructions. We use the system to acquire patient data at the University of New Mexico Hospital for clinical studies. We present some preliminary imaging results of in vivo patient ultrasound data. Our preliminary clinical imaging results show promising of our breast ultrasound tomography system with two parallel transducer arrays for breast cancer imaging and characterization.

  1. Investigating the productivity model for clinical nurses.

    Science.gov (United States)

    Dehghan Nayeri, Nahid; Hooshmand Bahabadi, Abbas; Kazemnejad, Anoshirvan

    2014-01-01

    One of the main objectives of quantitative researches is assessment of models developed by qualitative studies. Models validation through their testing implies that the designed model is representative of the existed facts. Hence, this study was conducted to assess the clinical nurses' productivity model presented for Iranian nurses' productivity. The sample of the study consisted of 360 nurses of Tehran University of Medical Sciences. The research tool was a questionnaire for measuring the components of clinical nurses' productivity. After completing all steps of instrument psychometric and getting answers from the participants, the factors introduced in the questionnaire were named and then Lisrel Path Analysis tests were performed to analyze the components of the model. The results of the model test revealed there is an internal relationship among different components of the model. Regression Analysis showed that each increasing unit in components of the model was to be added to central variable of productivity model -human resource. Model components altogether explained 20 % of clinical nurses' productivity variance. This study found that the important component of productivity is human resources that are reciprocally related to other components of the model. Therefore, it can be stated that the managers can promote the productivity by using efficient strategies to correct human resource patterns.

  2. CLINICAL AND INVESTIGATIONAL STUDY OF DIABETIC KETOACIDOSIS

    Directory of Open Access Journals (Sweden)

    Narasimham

    2015-06-01

    Full Text Available BACKGROUND AND OBJECTIVES: To compare the clinical features and biochemical profile in DKA. To assess the response in the patients with standard treatment of DKA. Clinical descriptions of polyuric states resembling diabetes mellitus have been described in the Ebers papyrus of Egypt in 15th century BC . 1,2 A yurvedic literature from the times of Charaka and Sushrutha, the ancient Indian physicians identified two forms of “MadhuMeha” ( H oneyed Urine in 400 BC . 3 John Rolo of England in 1797 was one of 1st who coined the term diabetes mellitus. William Prout of E ngland described diabetic coma during 1810 – 20. In 1886, Dreschfeld8 described DKA and HHNS (Hyper osmolar Hyperglycemic Non - ketotic Syndrome. In 1922 Banting , Best, Collip and Macleod isolated and clinically used insulin and later won Nobel prize for that memorable invention. SETTING: Inpatients of king George Hospital attached to Andhra Medical College, Visakhapatnam . METHODS: Diagnosis of diabetic ketoacidosis was made according to the inclusion criteria. Hyperglycemia >250 mg/dl, acidosis with blood pH <7.3, serum bicarbonate <15 mEq/l, urine positive for ketones. RESULTS: Of the 100 patients admitted for diabetic ketoacidosis; 84 had type 2 diabetes (84% and 16(16% were type I diabetes. Average age at the time of presentation was 42.9±12.9 years. Th e commonest precipitating factor was infection (56% followed by other factors (28% and irregular treatment (16%. The most common clinical features at the time of presentation were vomiting, abdominal pain, acidotic breathing and dehydration. The values for RBS, HCO3, and pH were 355.3±69.1, 14.9±3.4 and 7.2±0.1 respectively. INTERPRETATION AND CONCLUSION: Most common precipitating factors are infection and omission of insulin or irregular treatment. Most common clinical features at the time of presentati on are vomiting, abdominal pain, dehydration, acidotic breathing and tachycardia. Mortality rate in diabetic

  3. Oligocone trichromacy: clinical and molecular genetic investigations

    DEFF Research Database (Denmark)

    Andersen, Mette K G; Christoffersen, Nynne L B; Sander, Birgit

    2010-01-01

    of congenital nystagmus, and subjectively normal or near-normal color vision; five patients reported photophobia. Clinical examinations revealed largely normal fundi, normal Goldmann visual field results with the IV/4e target, and normal color discrimination or mild color vision deficiency. Electrophysiological...... of unknown significance in CNGB3 and PDE6C in two other patients. CONCLUSIONS: Oligocone trichromacy is a heterogeneous condition with respect to both phenotypic appearance and genetic background. The finding of mutations in genes known to be involved in complete and incomplete achromatopsia supports...

  4. Azoospermia: clinical, hormonal, and biochemical investigation.

    Science.gov (United States)

    Papadimas, J; Papadopoulou, F; Ioannidis, S; Spanos, E; Tarlatzis, B; Bontis, J; Mantalenakis, S

    1996-01-01

    The aim of this study was to evaluate the clinical, hormonal and biochemical characteristics of infertile men with azoospermia. A total of 187 azoospermic out of 2610 infertile men (7.2%) were studied. Mean testicular volume and basal plasma levels of FSH were the most useful parameters concerning the evaluation of azoospermia. Basal plasma levels of LH and T were useful only in azoospermic men with hypogonadism, whereas plasma PRL levels, semen volume, and seminal plasma fructose levels were not found to be of common use except in selected cases.

  5. Clinical Investigation of Benign Asbestos Pleural Effusion.

    Science.gov (United States)

    Fujimoto, Nobukazu; Gemba, Kenichi; Aoe, Keisuke; Kato, Katsuya; Yokoyama, Takako; Usami, Ikuji; Onishi, Kazuo; Mizuhashi, Keiichi; Yusa, Toshikazu; Kishimoto, Takumi

    2015-01-01

    There is no detailed information about benign asbestos pleural effusion (BAPE). The aim of the study was to clarify the clinical features of BAPE. The criteria of enrolled patients were as follows: (1) history of asbestos exposure; (2) presence of pleural effusion determined by chest X-ray, CT, and thoracentesis; and (3) the absence of other causes of effusion. Clinical information was retrospectively analysed and the radiological images were reviewed. There were 110 BAPE patients between 1991 and 2012. All were males and the median age at diagnosis was 74 years. The median duration of asbestos exposure and period of latency for disease onset of BAPE were 31 and 48 years, respectively. Mean values of hyaluronic acid, adenosine deaminase, and carcinoembryonic antigen in the pleural fluid were 39,840 ng/mL, 23.9 IU/L, and 1.8 ng/mL, respectively. Pleural plaques were detected in 98 cases (89.1%). Asbestosis was present in 6 (5.5%) cases, rounded atelectasis was detected in 41 (37.3%) cases, and diffuse pleural thickening (DPT) was detected in 30 (27.3%) cases. One case developed lung cancer (LC) before and after BAPE. None of the cases developed malignant pleural mesothelioma (MPM) during the follow-up.

  6. Clinical Investigation of Benign Asbestos Pleural Effusion

    Directory of Open Access Journals (Sweden)

    Nobukazu Fujimoto

    2015-01-01

    Full Text Available There is no detailed information about benign asbestos pleural effusion (BAPE. The aim of the study was to clarify the clinical features of BAPE. The criteria of enrolled patients were as follows: (1 history of asbestos exposure; (2 presence of pleural effusion determined by chest X-ray, CT, and thoracentesis; and (3 the absence of other causes of effusion. Clinical information was retrospectively analysed and the radiological images were reviewed. There were 110 BAPE patients between 1991 and 2012. All were males and the median age at diagnosis was 74 years. The median duration of asbestos exposure and period of latency for disease onset of BAPE were 31 and 48 years, respectively. Mean values of hyaluronic acid, adenosine deaminase, and carcinoembryonic antigen in the pleural fluid were 39,840 ng/mL, 23.9 IU/L, and 1.8 ng/mL, respectively. Pleural plaques were detected in 98 cases (89.1%. Asbestosis was present in 6 (5.5% cases, rounded atelectasis was detected in 41 (37.3% cases, and diffuse pleural thickening (DPT was detected in 30 (27.3% cases. One case developed lung cancer (LC before and after BAPE. None of the cases developed malignant pleural mesothelioma (MPM during the follow-up.

  7. A preliminary investigation of Nigerian Gmelina arborea and Bambusa vulgaris for pulp and paper production

    CSIR Research Space (South Africa)

    Azeez, MA

    2015-10-01

    Full Text Available 18(1): 65 - 78, 2016 DOI: 10.4067/S0718-221X2016005000007 ISSN impresa 0717-3644 ISSN online 0718-221X A PRELIMINARY INVESTIGATION OF NIGERIAN Gmelina arborea AND Bambusa vulgaris FOR PULP AND PAPER PRODUCTION... Mayowa Akeem Azeez1,♠, Jerome E. Andrew2, B. Bruce Sithole3 ABSTRACT Two common Nigerian-grown biomasses, gmelina (Gmelina arborea) and bamboo (Bambusaa vulgaris) have been pulped and their fibre characteristics and paper properties examined. The results...

  8. Preliminary Investigation of the Thermal Behavior of High-Speed Helical Gear Trains

    Science.gov (United States)

    Handschuh, Robert F.; Kilmain, Charles J.

    2002-01-01

    A preliminary experimental investigation of the thermal behavior of high-speed helical gears will be presented. A full-scale torque regenerative test stand has been built to test a representative helical gear train as that used in tiltrotor aircraft. Power loss and temperature data from a wide range of operating conditions were measured. Loop power ranged up to 3730 kW (5000 hp). Drive system components representative of flight quality hardware were used in the test program. The results attained in this initial study indicated that windage losses due to the high rotational speeds that were tested were far more important than the losses due to the gear meshing losses.

  9. Clinical Investigation Program Annual Progress Report

    Science.gov (United States)

    1989-10-01

    Neonates (C) 9A89 Kueser, T. J. Pediatric Intubatlon Training 115 Utlizing the Feline Model (0) xiii Protocol Number Page 361187 Lehman, R. M...3,309. Periodic Review Date: Sep 89 Gifts: None Decision: Continue OBJECTIVE: The objective of this proposed study is to elucidate the ecology of...Sheet m Prot No: 9A89 . Status: Ongoing m TITLE: Pediatric Intubation Training Utillzing the Feline Model Principal Investigator: COL Richard A. tIanks

  10. Clinical Investigation Program Annual Progress Report.

    Science.gov (United States)

    1985-09-30

    The Acute Scrotum in Childhood: A Review. In press - World J Urol. Wilson, T.M.: Retroperitoneal Fibrosis in Association with Abdominal Aortic Aneurysm...p2. .- I,-. -. % (C) Direct result of approved registered protocol. 󈧬, ~022 ;. Wilson, T.M.: Retroperitoneal Fibrosis in Association with Abdcminal...Michael Perry, COL, MC (9) Dept/Svc: Medicine/ Pulmonar (10) Assoc Investigators: (11) Key Words: Dead Space High Frequency Ventilation Carbon Dioxide (12

  11. A Preliminary Investigation of Ductility-Enhancement Mechanism through In Situ Nanofibrillation in Thermoplastic Matrix Composites

    Directory of Open Access Journals (Sweden)

    Bhaskar Patham

    2013-01-01

    Full Text Available A preliminary investigation of interrelationships between tensile stress-strain characteristics and morphology evolution during deformation is conducted on a commercially available thermoplastic composite with a low-surface-energy nanofibrillating poly(tetrafluoroethylene (PTFE additive. In this class of composites, the deformation-associated nanofibrillation of the low-surface-energy additive has been hypothesized to provide an additional dissipation mechanism, thereby enhancing the ductility of the composite. This class of composites offers potential for automotive light weighting in exterior and interior body and fascia applications; it is therefore of interest to investigate processing-structure-property interrelationships in these materials. This study specifically probes the interrelationships between the plastic deformation within the matrix and the fibrillation of the low-surface-energy additive; tensile tests are carried out at two different temperatures which are chosen so as to facilitate and suppress plastic deformation within the matrix polymer. Based on these preliminary investigations, it is noted that PTFE fibrillation acts synergistically with the ductile deformation of the matrix resin resulting in higher strains to failure of the composite; the results also suggest that the mechanism of fibrillation-assisted enhancement of strains to failure may not operate in the absence of matrix plasticity.

  12. Clinical investigation on gastric oxalate absorption

    Institute of Scientific and Technical Information of China (English)

    陈志强; 叶章群; 曾令启; 杨为民

    2003-01-01

    Objective To study the stomach role in exogenous oxalate absorption.Methods The kinetic variation of urinary oxalate excretion (mg/min) in 10 healthy adults and 8 patients who underwent total gastrectomy was investigated before and after an oral spinach oxalate load. The bioavailability of the oxalate load in the healthy adults was calculated and compared with that in the patients.Results The oxalate content in the oral spinach load was 2567-2670 mg. The urinary oxalate excretion (mg/min) in the 10 healthy adults increased significantly 20 minutes after loading (this increase was compared against their basic oxalate excretion level of 0.0331±0.0203). Further observations after loading include: a first peak of oxalate excretion 40 minutes after loading; an oxalate excretion level double that of the basic level after 60 minutes (0.0732±0.0294) and a second peak appearing at 3 hours (P<0.01). A "first peak" (0.063%±0.062%) was not in any of the patients who underwent a total gastrectomy. Furthermore, a bioavailability of oxalate, which was 50% lower than that in the healthy subjects, appeared 60 minutes after loading (0.098%±0.071%, P<0.01). Conclusions The stomach is a powerful oxalate absorption organ under normal physiological conditions. Further investigation on the relationship between stomach dysfunction and urinary calcium oxalate formation is needed.

  13. R&D Requirements, RF Gun Mode Studies, FEL-2 Steady-StateStudies, Preliminary FEL-1 Time-Dependent Studies, and Preliminary LayoutOption Investigation

    Energy Technology Data Exchange (ETDEWEB)

    Byrd, John; Corlett, John; Doolittle, Larry; Fawley, William; Lidia, Steven; Penn, Gregory; Ratti, Alex; Staples, John; Wilcox Russell; Wurtele, Jonathan; Zholents, Alexander

    2005-10-01

    This report constitutes the third deliverable of LBNLs contracted role in the FERMI {at} Elettra Technical Optimization study. It describes proposed R&D activities for the baseline design of the Technical Optimization Study, initial studies of the RF gun mode-coupling and potential effects on beam dynamics, steady-state studies of FEL-2 performance to 10 nm, preliminary studies of time-dependent FEL-1 performance using electron bunch distribution from the start-to-end studies, and a preliminary investigation of a configuration with FEL sinclined at a small angle from the line of the linac.

  14. Clinical investigation of surgery for intermittent exotropia

    Institute of Scientific and Technical Information of China (English)

    Chong-qing YANG; Ye SHEN; Yang-shun GU; Wei HAN

    2008-01-01

    Objective: To investigate the time and postoperative binocular vision of strabismus surgery for children with intermittent exotropia (X (T)). Methods: A retrospective investigation was conducted in 80 child patients with intermittent exotropia. Pre- and postoperative angles of deviation fixating at near (33cm) and distant targets (6m) were measured with the prolonged alternate cover testing. The binocular function was assessed with synoptophore. Twenty-one patients took the postoperative synoptophore exercise. Results: (1) A week after surgery, 96.2% of the 80 patients had binocular normotopia, while a year after surgery, 91.3% of the 80 patients had binocular normotopia; (2) Preoperatively, 58 patients had near stereoacuity, while postoperatively, 72 patients achieved near stereoacuity (P<0.05); (3) Preoperatively, 64 patients had Grade I for the synoptophore evaluation and postoperatively, 76 patients achieved Grade I. Meanwhile, 55 patients had Grade Ⅱpreoperatively and 72 achieved Grade Ⅱ postoperatively. For Grade Ⅲ, there were 49 patients preoperatively and 64 patients postoperatively (P<0.05); (4) Patients of 5~8 years old had a significantly better recovery rate of binocular vision than those of 9~18 years old (P<0.05); (5)Patients taking postoperative synoptophore exercise had a better binocular vision than those taking no exercise (P<0.05). Conclusions: (1) Strabismus surgery can help to preserve or restore the binocular vision for intermittent exotropia; (2) Receiving the surgery at young ages may develop better postoperative binocular vision; (3) The postoperative synoptophore exercise can help to restore the binocular vision.

  15. A preliminary study of intravenous surfactants in paraplegic dogs: polymer therapy in canine clinical SCI.

    Science.gov (United States)

    Laverty, Peter H; Leskovar, Alenka; Breur, Gert J; Coates, Joan R; Bergman, Robert L; Widmer, William R; Toombs, James P; Shapiro, Scott; Borgens, Richard B

    2004-12-01

    Hydrophilic polymers, both surfactants and triblock polymers, are known to seal defects in cell membranes. In previous experiments using laboratory animals, we have exploited this capability using polyethylene glycol (PEG) to repair spinal axons after severe, standardized spinal cord injury (SCI) in guinea pigs. Similar studies were conducted using a related co-polymer Poloxamer 188 (P 188). Here we carried out initial investigations of an intravenous application of PEG or P 188 (3500 Daltons, 30% w/w in saline; 2 mL/kg I.V. and 2 mL/kg body weight or 300 mL P 188 per kg, respectively) to neurologically complete cases of paraplegia in dogs. Our aim was to first determine if this is a clinically safe procedure in cases of severe naturally occurring SCI in dogs. Secondarily, we wanted to obtain preliminary evidence if this therapy could be of clinical benefit when compared to a larger number of similar, but historical, control cases. Strict entry criteria permitted recruitment of only neurologically complete paraplegic dogs into this study. Animals were treated by a combination of conventional and experimental techniques within approximately 72 h of admission for spinal trauma secondary to acute, explosive disk herniation. Outcome measures consisted of measurements of voluntary ambulation, deep and superficial pain perception, conscious proprioception in hindlimbs, and evoked potentials (somatosensory evoked potentials [SSEP]). We determined that polymer injection is a safe adjunct to the conventional management of severe neurological injury in dogs. We did not observe any unacceptable clinical response to polymer injection; there were no deaths, nor any other problem arising from, or associated with, the procedures. Outcome measures over the 6-8-week trial were improved by polymer injection when compared to historical cases. This recovery was unexpectedly rapid compared to these comparator groups. The results of this pilot trial provides evidence consistent with the

  16. Clinical investigation of fatty liver by CT

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Katsumoto; Takayama, Tetsuo; Sano, Hiroshi; Katada, Naoyuki; Takeichi, Masayuki

    1984-09-01

    Of CT 6800 studies 56 cases of diffuse fatty infiltration confirmed by liver biopsy were investigated and compared with those of chronic hepatitis and liver cirrhosis. It was found that CT diagnosis of severe fatty infiltration (fatty liver) is specific when the ratios of CT values of liver to those of spleen are less than 0.85. This criterion was satisfied in 169 cases with fatty liver (diffuse: 141 cases, focal: 28 cases). Obesity, diabetes and alcohol abuse were the main causative factors in both diffuse and focal fatty liver. The percentage of cases showing no abnormal blood chemistry was high as compared with those in previous reports based on liver biopsy. The changes in CT values of the liver faithfully reflected the improvement of each causal factor and reciprocal changes were observed between diffuse and focal fatty liver in repeated CT examinationns. It was concluded that CT is useful in estimating the effect of treatment as well as in diagnosis of fatty liver.

  17. A Preliminary Investigation of the Hanger Vibrations on the Great Belt East Bridge

    DEFF Research Database (Denmark)

    Gjelstrup, Henrik; Georgakis, Christos; Larsen, Allan

    2007-01-01

    On March 29, 2001, the Great Belt East Bridge exhibited large-amplitude hanger vibrations having elliptical orbits for wind speeds of between 16 - 17 m/s. Vibration amplitudes were in the order of 1.4m in the across-wind direction and 1.0m in the along-wind. In this paper, a preliminary...... investigation behind the causes of this relatively isolated hanger vibration event on the Great Belt East Bridge is undertaken. One of the main assumptions of the investigation is that coincidental icy conditions may have contributed in some way to large hanger response, by changing the cylindrical cross...... of the vibrations it is assumed that the aerodynamic moment coefficient is zero....

  18. Preliminary clinical nursing leadership competency model: a qualitative study from Thailand.

    Science.gov (United States)

    Supamanee, Treeyaphan; Krairiksh, Marisa; Singhakhumfu, Laddawan; Turale, Sue

    2011-12-01

    This qualitative study explored the clinical nursing leadership competency perspectives of Thai nurses working in a university hospital. To collect data, in-depth interviews were undertaken with 23 nurse administrators, and focus groups were used with 31 registered nurses. Data were analyzed using content analysis, and theory development was guided by the Iceberg model. Nurses' clinical leadership competencies emerged, comprising hidden characteristics and surface characteristics. The hidden characteristics composed three elements: motive (respect from the nursing and healthcare team and being secure in life), self-concept (representing positive attitudes and values), and traits (personal qualities necessary for leadership). The surface characteristics comprised specific knowledge of nurse leaders about clinical leadership, management and nursing informatics, and clinical skills, such as coordination, effective communication, problem solving, and clinical decision-making. The study findings help nursing to gain greater knowledge of the essence of clinical nursing leadership competencies, a matter critical for theory development in leadership. This study's results later led to the instigation of a training program for registered nurse leaders at the study site, and the formation of a preliminary clinical nursing leadership competency model.

  19. The clinical investigator-subject relationship: a contextual approach

    Directory of Open Access Journals (Sweden)

    Resnik David B

    2009-12-01

    Full Text Available Abstract Background The nature of the relationship between a clinical investigator and a research subject has generated considerable debate because the investigator occupies two distinct roles: clinician and scientist. As a clinician, the investigator has duties to provide the patient with optimal care and undivided loyalty. As a scientist, the investigator has duties to follow the rules, procedures and methods described in the protocol. Results and conclusion In this article, I present a contextual approach to the investigator-subject relationship. The extent of the investigator's duty to provide the patient/subject with clinical care can vary from one situation to the next, as a function of several factors, including: the research design, benefits and risks of the research; the subject's reasonable expectations, motivations, and vulnerabilities; the investigator's ability to benefit the subject; and the investigator's prior relationship with the subject. These and other factors need to be considered when determining the clinical investigator's obligations to provide clinical care to human research subjects. In some research contexts, the investigator has extensive clinical obligations to the patient/subject; in others, the investigator has minimal ones.

  20. CEM V based special cementitious materials investigated by means of SANS method. Preliminary results

    Science.gov (United States)

    Dragolici, A. C.; Balasoiu, M.; Orelovich, O. L.; Ionascu, L.; Nicu, M.; Soloviov, D. V.; Kuklin, A. I.; Lizunov, E. I.; Dragolici, F.

    2017-05-01

    The management of the radioactive waste assume the conditioning in a cement matrix as an embedding, stable, disposal material. Cement matrix is the first and most important engineering barrier against the migration in the environment of the radionuclides contained in the waste packages. Knowing how the microstructure develops is therefore desirable in order to assess the compatibility of radioactive streams with cement and predict waste form performance during storage and disposal. For conditioning wastes containing radioactive aluminum new formulas of low basicity cements, using coatings as a barrier between the metal and the conditioning environment or introducing a corrosion inhibitor in the matrix system are required. Preliminary microstructure investigation of such improved CEM V based cement matrix is reported.

  1. A preliminary investigation of the use of throttles for emergency flight control

    Science.gov (United States)

    Burcham, F. W., Jr.; Fullerton, C. Gordon; Gilyard, Glenn B.; Wolf, Thomas D.; Stewart, James F.

    1991-01-01

    A preliminary investigation was conducted regarding the use of throttles for emergency flight control of a multiengine aircraft. Several airplanes including a light twin-engine piston-powered airplane, jet transports, and a high performance fighter were studied during flight and piloted simulations. Simulation studies used the B-720, B-727, MD-11, and F-15 aircraft. Flight studies used the Lear 24, Piper PA-30, and F-15 airplanes. Based on simulator and flight results, all the airplanes exhibited some control capability with throttles. With piloted simulators, landings using manual throttles-only control were extremely difficult. An augmented control system was developed that converts conventional pilot stick inputs into appropriate throttle commands. With the augmented system, the B-720 and F-15 simulations were evaluated and could be landed successfully. Flight and simulation data were compared for the F-15 airplane.

  2. Preliminary investigation on the relation between maximum wave height and wave spectra

    Science.gov (United States)

    Tao, Aifeng; Wen, Cheng; Wu, Yuqing; Wu, Haoran; Li, Shuo; Cao, Guangsui

    2016-04-01

    The maximum wave height is important not only for the determination of design wave parameters but also for the marine disaster defense. While it cannot be predicted straightforwardly at present, since the general numerical models for wave forecasting are all based on phase averaged spectra model. Then it becomes very useful to make clear the relationship between the maximum wave height and wave spectra parameters, such as average wave steepness, spectra width and spectra type, such as one single peak spectra or multi peaks spectra. In order to perform this research procedure, plenty of observed wave data are required. We collected ten years wave data measured from a ship in North Sea, one year wave pressure data from nine points around Korea, four years buoy data from three points along Chinese coast. The preliminary investigation results on the relations between maximum waves and spectra via the mention observed data will be present here.

  3. PRELIMINARY PHYTOCHEMICAL INVESTIGATION AND ANTHELMINTIC ACTIVITY OF ACACIA SUMA (ROXB BARKS

    Directory of Open Access Journals (Sweden)

    Acharyya Suman

    2011-01-01

    Full Text Available The present work was conducted to investigate the preliminary phytochemical studies and anthelmintic activities on the bark of Acacia suma (Roxb. Family- Fabaceae against adult Indian earthworms, Pheretima posthuma. Various concentrations (5-25 mg/ml of each extract along with the reference samples (Piperazine citrate, Albendazole were subjected for anthelmintic activity study. The qualitative test revealed that the petroleum ether extracts contained only terpenoids but chloroform and hydroalcoholic (Methanol 70% v/v extracts exhibited the presence of carbohydrates, alkaloids, glycosides, flavonoids, tannins and saponins but amino acids and steroids were absent. All the extracts showed anthelmintic activity when compared with petroleum ether and chloroform extracts. The anthelmintic activity of hydroalcoholic extract was comparable with reference drugs.

  4. Investigation of fracture-matrix interaction: Preliminary experiments in a simple system

    Energy Technology Data Exchange (ETDEWEB)

    Foltz, S.D. [New Mexico Univ., Albuquerque, NM (United States). Dept. of Physics and Astronomy; Tidwell, V.C.; Glass, R.J.; Sobolik, S.R. [Sandia National Labs., Albuquerque, NM (United States)

    1992-12-31

    Paramount to the modeling of unsaturated flow and transport through fractured porous media is a clear understanding of the processes controlling fracture-matrix interaction. As a first step toward such an understanding, two preliminary experiments have been performed to investigate the influence of matrix imbibition on water percolation through unsaturated fractures in the plane normal to the fracture. Test systems consisted of thin slabs of either tuff or an analog material cut by a single vertical fracture into which a constant fluid flux was introduced. Transient moisture content and solute concentration fields were imaged by means of x-ray absorption. Flow fields associated with the two different media were significantly different owing to differences in material properties relative to the imposed flux. Richards` equation was found to be a valid means of modeling the imbibition of water into the tuff matrix from a saturated fracture for the current experiment.

  5. Preliminary phytochemical investigation and thin layer chromatography profiling of sequential extracts of Moringa oleifera pods

    Directory of Open Access Journals (Sweden)

    Veena Sharma

    2013-01-01

    Full Text Available Context: Moringa oleifera Lam (Moringaceae is a highly valued plant, distributed in many countries of the tropics and subtropics. It has an impressive range of medicinal uses with high nutritional value. Aim: The present study, primarily aims to carry out a preliminary phytochemical screening so as to detect the major class of compounds present in M. oleifera and to perform thin layer chromatography (TLC profiling of all sequential extracts. Materials and Methods: Phytochemical analysis was performed by various qualitative methods and TLC profiling was carried out using various solvent system of varying polarity. Results and Conclusions: Qualitative phytochemical analysis reflects the presence of phenolics, triterpenoids, cardiac glycosides, steroid, alkaloids and saponin in the plant extract. TLC profiling of the M. oleifera pods was carried out using sequential extracts of petroleum ether, benzene, petroleum ether, benzene, chloroform, ethyl acetate, ethanol and water respectively. The results obtained in the present investigation indicated M. oleifera pods as a rich source of natural antioxidants.

  6. Physiological Markers of Arousal Change with Psychological Treatment for Insomnia: A Preliminary Investigation.

    Directory of Open Access Journals (Sweden)

    Christopher B Miller

    Full Text Available The aim of this preliminary study was to evaluate if Sleep Restriction Therapy for insomnia is associated with modifications to physiological arousal, indexed through overnight measures of plasma cortisol concentrations and core body temperature.In a pre-to-post open label study design, eleven patients with chronic and severe Psychophysiological Insomnia underwent 5 weeks of Sleep Restriction Therapy.Eight (73% patients out of 11 consented completed therapy and showed a decrease in insomnia severity pre-to-post treatment (mean (SD: 18.1 (2.8 versus 8.4 (4.8; p = .001. Six patients were analyzed with pre-to-post overnight measures of temperature and cortisol. Contrary to our hypothesis, significantly higher levels of plasma cortisol concentrations were found during the early morning at post-treatment compared to baseline (p < .01, while no change was observed in the pre-sleep phase or early part of the night. Core body temperature during sleep was however reduced significantly (overall mean [95% CI]: 36.54 (°C [36.3, 36.8] versus 36.45 [36.2, 36.7]; p < .05.Sleep Restriction Therapy therefore was associated with increased early morning cortisol concentrations and decreased core body temperature, supporting the premise of physiological changes in functioning after effective therapy. Future work should evaluate change in physiological variables associated with clinical treatment response.Australian New Zealand Clinical Trials Registry ANZCTR 12612000049875.

  7. Predicting Improvement in Depression Across Therapies Using Indicators of Romantic Relationship Functioning: A Preliminary Investigation.

    Science.gov (United States)

    Woods, Sarah B; Priest, Jacob B; Denton, Wayne H

    2015-01-01

    Depression is a common presenting problem, often affected by couple interactions in unique ways. However, research in the area of romantic relationship functioning and depression often replicates previous research or consists of literature reviews, limiting the clinical relevancy. The purpose of this preliminary study is to expand the research on the effects of relational processes on depression treatment outcomes. We tested whether initiator tendency, attachment anxiety, attachment avoidance, and marital satisfaction predicted improvement in depression for women with Major Depressive Disorder enrolled in a depression treatment clinical trial (n = 17). Women completed treatments of either pharmacotherapy or combined Emotionally Focused Therapy for couples and pharmacotherapy. We found that higher baseline levels of partner initiator tendency resulted in less change in depression (worse outcomes), regardless of treatment type and that higher baseline levels of attachment avoidance predicted better depression outcomes in treatment. Marital satisfaction, however, was not linked to change in depression. Initiator tendency is discussed as a critical romantic relationship factor for depression treatment outcomes.

  8. Clinical assessment, neuroimaging and immunomarkers in Chagas disease study (CLINICS: rationale, study design and preliminary findings

    Directory of Open Access Journals (Sweden)

    Jamary Oliveira-Filho

    Full Text Available ABSTRACT Chagas disease (CD is an important cause of cardiomyopathy and stroke in Brazil. Brain infarcts and atrophy seem to occur independently of cardiomyopathy severity and cognitive impairment is understudied. Objective: Compare the prevalence of brain magnetic resonance imaging abnormalities between patients with or without CD; determine if inflammatory biomarkers are increased in CD; and determine the efficacy of aspirin in reducing the rate of microembolization in these patients. Methods: 500 consecutive patients with heart failure will undergo a structured cognitive evaluation, biomarker collection and search for microembolic signals on transcranial Doppler. The first 90 patients are described, evaluated with cognitive tests and brain magnetic resonance imaging to measure N-acetyl aspartate (NAA, choline (Cho, myo-inositol (MI and creatine (Cr. Results: Mean age was 55±11 years, 51% female, 38 (42% with CD. Mean NAA/Cr ratio was lower in patients with CD as compared to other cardiomyopathies. Long-term memory and clock-drawing test were also significantly worse in CD patients. In the multivariable analysis correcting for ejection fraction, age, sex and educational level, reduced NAA/Cr (p=0.006 and cognitive dysfunction (long-term memory, p=0.023; clock-drawing test, p=0.015 remained associated with CD. Conclusion: In this preliminary sample, CD was associated with cognitive impairment and decreased NAA/Cr independently of cardiac function or educational level.

  9. Clinical evaluation of children testing positive in screening tests for attention-deficit/hyperactivity disorder: A preliminary report

    Directory of Open Access Journals (Sweden)

    Maria Skounti

    2009-06-01

    Full Text Available Background and Objectives: Screening tests are of great diagnostic value in attention-deficit/hyperactivity disorder (ADHD, however final diagnosis relies on a clinical examination by an expert. The objective of the present study was to clinically evaluate children who had been screened positive for ADHD through both a parent and a teacher questionnaire. Methods: Parent interview and child behavior checklist and clinical assessment were used to confirm the preliminary diagnosis in 42 children aged 8 years, who have been screened positive for ADHD out of 1,708 children, in a large, two-setting screening study conducted in Crete, Greece. Results: The diagnosis of ADHD was confirmed for 31 children (74%. In the remaining 11 children, ADHD manifestations were attributed to other primary disorders. None of the 42 children was classified as lacking symptoms suggesting ADHD. Among the 31 children with confirmed ADHD, only 2 had been diagnosed prior to the screening test. Conclusions: Although clinical evaluation is the golden standard for diagnosis of ADHD, two-setting screening questionnaires by parent and teacher are useful tools in identifying children who need further investigation and intervention.

  10. Clinical and neuroimaging correlates of antiphospholipid antibodies in multiple sclerosis: a preliminary study

    Directory of Open Access Journals (Sweden)

    Gonzalez-Toledo Eduardo

    2007-10-01

    Full Text Available Abstract Background The presence of antiphospholipid antibodies (APLA in multiple sclerosis (MS patients has been reported frequently but no clear relationship between APLA and the clinical and neuroimaging features of MS have heretofore been shown. We assessed the clinical and neuroimaging features of MS patients with plasma APLA. Methods A consecutive cohort of 24 subjects with relapsing-remitting (RR MS were studied of whom 7 were in remission (Rem and 17 in exacerbation (Exc. All subjects were examined and underwent MRI of brain. Patients' plasma was tested by standard ELISA for the presence of both IgM and IgG antibodies using a panel of 6 targets: cardiolipin (CL, β2 glycoprotein I (β2GPI, Factor VII/VIIa (FVIIa, phosphatidylcholine (PC, phosphatidylserine (PS and phosphatidylethanolamine (PE. Results In exacerbation up to 80% of MS subjects had elevated titers of IgM antibodies directed against the above antigens. However, in remission, less than half of MS patients had elevated titers of IgM antibodies against one or more of the above antigens. This difference was significant, p Conclusion The findings of this preliminary study show that increased APLA IgM is associated with exacerbations of MS. Currently, the significance of this association in pathogenesis of MS remains unknown. However, systematic longitudinal studies to measure APLA in larger cohorts of patients with relapsing-remitting MS, particularly before and after treatment with immunomodulatory agents, are needed to confirm these preliminary findings.

  11. 胫骨后倾截骨对后十字韧带保留型全膝关节置换术疗效的影响%Investigation of preliminary clinical outcome following PCL-retaining total knee arthroplasty with posterior tibial slope

    Institute of Scientific and Technical Information of China (English)

    肖瑜; 张福江; 郭军; 任凯晶; 于建华; 高志国

    2010-01-01

    Objective To investigate the preliminary clinical outcome following PCL-retaining total knee arthroplasty (TKA) with 0°or 5°posterior tibial slope. Methods From Jan 2008 to Mar 2009, 84 patients (84 knees) with osteoarthritis (OA) underwent primary PCL-retaining TKA operations by the same surgical team. Among them, 27 patients (7 males, 20 females, with the average age of 69.5 years) underwent TKA using a cutting block and intramedullary cutting guide designed to impart a 5° posterior tibial slope (group A); 57 patients (15 males, 42 females, with the average age of 67.4 years) underwent TKA using a cutting block and intramedullary cutting guide designed to impart a 5°posterior tibial slope (group B). The preoperative demographic data and functional data had no statistical differences. The postoperative tibial posterior angle, maximum extension, maximum flexion and Knee Society Score (KSS) were compared between the two groups. Results All patients were followed up 12~24 months with an average of 15.7 months. No paralysis, wound infection, prosthesis dislocation and loosening were found. The postoperative tibial posterior angle was 5.7°±2.1° in group A and 0.9°±0.6°in group B (P< 0.05). The postoperative maximum extension was 0.8°±0.3°in group A and 1.2°±0.4°in group B (P >0.05). The postoperative maximum flexion was 115.7°±4.8°in group A and 101.1°±5.6°in group B (P< 0.05). The postoperative KSS was 87.6±5.9 in group A and 83.3±7.2 in group B (P >0.05). Conclusion Increasing tibial posterior slope improved the postoperative maximum flexion, but not the maximum extension and KSS, in PCL-retaining TKA.%目的 探讨胫骨后倾截骨对后十字韧带保留型全膝关节置换术后临床疗效的影响.方法 2008年1月至2009年3月应用胫骨后倾5°截骨(后倾组)进行后十字韧带保留型全膝关节置换治疗骨关节炎患者27例(27膝),男7例7膝,女20例20膝;平均年龄69.5岁.同期应用胫骨后倾0

  12. Preliminary investigation of cement materials in the Taif area, Saudi Arabia

    Science.gov (United States)

    Martin, Conrad

    1970-01-01

    A preliminary investigation of possible sources of cement rock in the Taft area was made during the latter part of August 1968. Adequate deposits of limestone, clay, quartz conglomerate and sandstone, and pisolitic iron ore, yet no gypsum, were located to support a Cement plant should it prove feasible to establish one in this area. These materials, made up mostly of Tertiary and later sediments, crop out in isolated, inconspicuous low hills in a north- trending belt, 10 to 15 kilometers wide, lying about 90 kilometers to-the east of At Taft. The belt extends for more than 90 kilometers from the vicinity of Jabal 'An in the south to the crushed rock pits at Radwan and beyond in the north. The area is readily accessible either from the Talf-Riyadh highway or from the Taif-Bishah road presently under construction. The limestone, which is quite pure and dense in some localities but dolomitic, argillaceous, and cherty in others, occurs in a variety of colors and would make suitable decorative building stone. The volcanic rocks of the Harrat Hadan, lying directly to the east of the limestone belt, include volcanic ash beds some of which may have been altered to bentonitlc clays. Others may have been lithified and might be suitable for light-weight aggregate. These possibilities remain to be investigated. Precambrian metamorphic rocks lying directly to the south and southeast of Taif were also investigated as possible cement rock sources, but no suitable material was found here.

  13. Disclosure of investigators' recruitment performance in multicenter clinical trials

    DEFF Research Database (Denmark)

    Dal-Ré, Rafael; Moher, David; Gluud, Christian;

    2011-01-01

    Rafael Dal-Ré and colleagues argue that the recruitment targets and performance of all site investigators in multi-centre clinical trials should be disclosed in trial registration sites before a trial starts, and when it ends.......Rafael Dal-Ré and colleagues argue that the recruitment targets and performance of all site investigators in multi-centre clinical trials should be disclosed in trial registration sites before a trial starts, and when it ends....

  14. Protocol-writing support conferences for investigator-initiated clinical trials

    Directory of Open Access Journals (Sweden)

    Goto M

    2016-04-01

    Full Text Available Masaya Goto,1 Yoshihiro Muragaki,2 Atsushi Aruga1 1Cooperative Major in Advanced Biomedical Sciences, Joint Graduate School of Tokyo Women's Medical University and Waseda University, 2Intelligent Clinical Research and Innovation Center, Tokyo Women's Medical University, Tokyo, Japan Abstract: In investigator-initiated clinical trials, protocols with inappropriate methods might cause bias. However, insufficient data are available to determine which items are important or difficult to discuss in protocol development. We recorded protocol-writing support conferences to determine what items methodologists and investigators discussed. We obtained approval from all applicants to attend our Intelligent Clinical Research and Innovation Center writing support conferences, recorded all the discussions, characterized them, and sorted the items iteratively. In 1 year, we had 18 conferences: nine early protocol conferences and nine rejected protocol conferences. The latter were rejected by the institutional review board, which requested consultation. The most discussed item was outcomes, accounting for ~20% of the total discussion time. In three trials, the main problem was multiple primary outcomes. The second most discussed item was control. Early protocol conferences had more non-preliminary proposal items than rejected ones (P<0.001. This study showed important items (especially outcomes and control for investigators to write protocols. Early protocol-writing conferences helped investigators find questionable items. Keywords: investigator-initiated clinical trials, support, protocol-writing, conferences, recording

  15. Nonattendance at a hospital-based otolaryngology clinic: a preliminary analysis within a universal healthcare system.

    Science.gov (United States)

    Zirkle, Molly S; McNelles, Laurie R

    2011-08-01

    Missed appointments at specialty clinics generate concerns for physicians and clinic administrators. Appointment nonattendance obstructs the provision of timely medical interventions and the maximization of systemic efficiencies. Yet, empiric study of factors associated with missed appointments at adult specialty clinics has received little attention in North America. We conducted a preliminary study of otolaryngology clinic nonattendance in the context of a universal healthcare system environment in Canada. Our data were based on the schedule of 1,512 new patient appointments at a hospital-based clinic from May 1 through Sept. 30, 2008. Gathered information included the employment status of the attending physician (i.e., full-time vs. part-time), the patient's sex and age, the day of the week and the time of the appointment, and the attendance status. We found that the rate of nonattendance was 24.4% (n = 369). Nonattendance rates varied significantly according to physician employment status (more common for part-time physicians), patient sex (women) and age (younger adults), and the day of the appointment (Wednesdays), but not according to the time of day. Our findings suggest that there are predictable patient and systemic factors that influence nonattendance at medical appointments. Awareness of these factors can have implications for the delivery of healthcare services within a universal healthcare context.

  16. Revisiting shyness and sociability: A preliminary investigation of hormone-brain-behavior relations

    Directory of Open Access Journals (Sweden)

    Alva eTang

    2014-12-01

    Full Text Available Shyness and sociability are two fundamental personality dimensions that are conceptually and empirically orthogonal and are conserved across cultures, development, and phylogeny. However, we know relatively little regarding how shyness and sociability are represented and maintained in the brain. Here we examined neural responses to the processing of different types of social threat using event-related fMRI, the salivary cortisol awakening response (CAR, and sociability in young adults selected for high and low shyness. Shy adults who exhibited a relatively higher CAR displayed neural activity in putative brain regions involved in emotional conflict and awareness, and were more sociable. In contrast, shy adults who displayed a relatively lower CAR exhibited neural activity in putative brain regions linked to fear and withdrawal, and were unsociable. Results revealed no systematic brain responses to social threat processing that correlated with the CAR in nonshy adults. These preliminary results suggest that individual differences in waking morning cortisol levels may influence neural processes that facilitate either social approach or withdrawal among people who are shy. Findings are discussed in relation to their theoretical and clinical implications for moving beyond longstanding descriptive to explanatory models of shyness and sociability and for understanding individual differences in social behavior in general.

  17. Brief cognitive behavior therapy in patients with social anxiety disorder: A preliminary investigation

    Directory of Open Access Journals (Sweden)

    Ravikant G Pinjarkar

    2015-01-01

    Full Text Available Context: Cognitive behavior therapy (CBT is the treatment of choice in anxiety disorders. However, there is little evidence for the effectiveness brief CBT in social anxiety. Aims: We examined the effectiveness of a brief CBT of six sessions in patients with social anxiety disorder. Settings and Design: A single case design study baseline; post and 1 month follow-up was adopted. Materials and Methods: Seven patients with a DSM IV diagnosis of social anxiety underwent 6 weekly sessions of brief CBT. Their diagnosis was confirmed using structured diagnostic interviews. They were assessed at baseline, post and 1-month follow-up on CGI- Severity, Leibowitz Social Anxiety Scale (LSAS, Social Phobia Rating Scale, Brief Fear of Negative Evaluation, and Beck′s Depression Inventory. Statistical Analysis: Data were analyzed using the method of clinical significance. Results: Results indicated that brief CBT was effective in reducing social anxiety in all patients. Brief CBT was also effective in reducing social avoidance and self consciousness. However, brief CBT was not effective in reducing fear of negative evaluation in all patients, suggesting the need for longer duration for cognitive changes in some dysfunctional beliefs. Conclusions: This preliminary case series indicates that brief CBT may be a promising and a cost and time effective approach to managing for social anxiety.

  18. Brief cognitive behavior therapy in patients with social anxiety disorder: a preliminary investigation.

    Science.gov (United States)

    Pinjarkar, Ravikant G; Sudhir, Paulomi M; Math, Suresh Bada

    2015-01-01

    Cognitive behavior therapy (CBT) is the treatment of choice in anxiety disorders. However, there is little evidence for the effectiveness brief CBT in social anxiety. We examined the effectiveness of a brief CBT of six sessions in patients with social anxiety disorder. A single case design study baseline; post and 1 month follow-up was adopted. Seven patients with a DSM IV diagnosis of social anxiety underwent 6 weekly sessions of brief CBT. Their diagnosis was confirmed using structured diagnostic interviews. They were assessed at baseline, post and 1-month follow-up on CGI- Severity, Leibowitz Social Anxiety Scale (LSAS), Social Phobia Rating Scale, Brief Fear of Negative Evaluation, and Beck's Depression Inventory. Data were analyzed using the method of clinical significance. Results indicated that brief CBT was effective in reducing social anxiety in all patients. Brief CBT was also effective in reducing social avoidance and self consciousness. However, brief CBT was not effective in reducing fear of negative evaluation in all patients, suggesting the need for longer duration for cognitive changes in some dysfunctional beliefs. This preliminary case series indicates that brief CBT may be a promising and a cost and time effective approach to managing for social anxiety.

  19. Assessment of technical documentation of medical devices for clinical investigation

    NARCIS (Netherlands)

    Roszek B; Bruijn ACP de; Drongelen AW van; Geertsma RE; BMT

    2007-01-01

    The technical documentation on non-market approved medical devices intended for clinical investigation contains major shortcomings. This could imply increased risks which could affect patient safety. The investigation described here focused on the availability and quality of the technical documentat

  20. Preliminary evaluation of an experimental clinical chemistry analyzer developed for space medicine.

    Science.gov (United States)

    Wu, A H; Gornet, T G; Schenkel, O; Smith-Cronin, L; Graham, G A; Tonnesen, A S; McKinley, B A

    1993-01-01

    An experimental clinical chemistry analyzer system was designed and built to demonstrate the feasibility of clinical chemistry as part of a medical-care system at NASA's planned space station Freedom. We report the performance of the experimental analyzer, called a medical development unit (MDU), for selected analytes in a laboratory setting in preparation for a preliminary clinical trial at patients' bedsides in an intensive-care unit. Within-run CVs ranged from 0.7% for sodium to 7.1% for phosphorus; day-to-day CVs ranged from 1.0% for chloride to 23.4% for calcium. Correlation of patients' blood sample analyses compared well with those by Ektachem E700 and other high-volume central laboratory analyzers (r ranged from 0.933 for creatine kinase MB isoenzyme to 0.997 for potassium), except for hemoglobin (r = 0.901) and calcium (r = 0.823). Although several CVs obtained in this study exceeded theoretical desired precision limits based on biological variations, performance was adequate for clinical laboratory diagnosis. We examined the effect of potentially interfering concentrations of hemoglobin, bilirubin, and lipids: the only effect was negative interference with calcium analyses by high concentrations of bilirubin. We also examined the effects of preanalytical variables and the performance of experimental sample-transfer cups designed to retain sample and reference liquid in microgravity. Continued development of the MDU system is recommended, especially automation of sample processing.

  1. Serotonin and Dopamine Gene Variation and Theory of Mind Decoding Accuracy in Major Depression: A Preliminary Investigation.

    Directory of Open Access Journals (Sweden)

    Arielle Y Zahavi

    Full Text Available Theory of mind-the ability to decode and reason about others' mental states-is a universal human skill and forms the basis of social cognition. Theory of mind accuracy is impaired in clinical conditions evidencing social impairment, including major depressive disorder. The current study is a preliminary investigation of the association of polymorphisms of the serotonin transporter (SLC6A4, dopamine transporter (DAT1, dopamine receptor D4 (DRD4, and catechol-O-methyl transferase (COMT genes with theory of mind decoding in a sample of adults with major depression. Ninety-six young adults (38 depressed, 58 non-depressed completed the 'Reading the Mind in the Eyes task' and a non-mentalistic control task. Genetic associations were only found for the depressed group. Specifically, superior accuracy in decoding mental states of a positive valence was seen in those homozygous for the long allele of the serotonin transporter gene, 9-allele carriers of DAT1, and long-allele carriers of DRD4. In contrast, superior accuracy in decoding mental states of a negative valence was seen in short-allele carriers of the serotonin transporter gene and 10/10 homozygotes of DAT1. Results are discussed in terms of their implications for integrating social cognitive and neurobiological models of etiology in major depression.

  2. Prospective investigation of serum anti-Müllerian hormone concentration in ovulatory intrauterine insemination patients: a preliminary study

    DEFF Research Database (Denmark)

    Freiesleben, N la Cour; Rosendahl, Mikkel; Johannsen, Trine Holm;

    2010-01-01

    This preliminary prospective study investigated serum anti-Müllerian hormone (AMH) through correlations to other basal parameters (123 patients) and according to ovarian response to 75 IU recombinant follicle-stimulating hormone (rFSH)/day (62 patients) in ovulatory patients' first rFSH treatment...

  3. Cognitive and Linguistic Sources of Variance in 2-Year-Olds' Speech-Sound Discrimination: A Preliminary Investigation

    Science.gov (United States)

    Lalonde, Kaylah; Holt, Rachael Frush

    2014-01-01

    Purpose: This preliminary investigation explored potential cognitive and linguistic sources of variance in 2- year-olds' speech-sound discrimination by using the toddler change/no-change procedure and examined whether modifications would result in a procedure that can be used consistently with younger 2-year-olds. Method: Twenty typically…

  4. Investigating antibiotic resistance in non-clinical environments

    Directory of Open Access Journals (Sweden)

    Fiona eWalsh

    2013-02-01

    Full Text Available There have been many calls for more information about the natural resistome and these have also highlighted the importance of understanding the soil resistome in the preservation of antibiotics for the treatment of infections. However, to date there have been few studies which have investigated the culturable soil resistome, which highlights the difficulties faced by microbiologists in designing these experiments to produce meaningful data. The World Health Organization definition of resistance is the most fitting to non-clinical environmental studies: Antimicrobial resistance is resistance of a microorganism to an antimicrobial medicine to which it was previously sensitive. The ideal investigation of non-clinical environments for antibiotic resistance of clinical relevance would be using standardized guidelines and breakpoints. This review outlines different definitions and methodologies used to understand antibiotic resistance and suggests how this can be performed outside of the clinical environment.

  5. Preliminary investigation into landslide in the national park Mt. Seorak in Korea

    Science.gov (United States)

    Lee, S.-K.; Choi, S.-Y.; Park, K.; Park, H.-D.

    2003-04-01

    There are 20 national parks with a site of superb scenic beauty in Korea. Total area covered by Mt. Seorak of Korean national parks is 354.6 km^2, which is of great value to be preserved naturally. Mt. Seorak is composed of granite, granitic gneiss and porphyroblastic gneiss. Mt. Seorak has been appointed as preservation area by IUCN(International Union for Conservation of Nature and Natural Resources) from early 1960's. Although a great number of people have visited to enjoy the beautiful panorama of Mt. Seorak, visitors are exposed to natural hazards, such as rock-fall, rockslide and debris flow. Based on preliminary investigation for total 68 sites on tracking routes, 7 sites were determined to be dangerous for visitors. Recently, rock-fall has occurred at 2 sites and debris flow happened at another 2 sites, where roads and tracking routes have been destroyed completely. In others, there is potential danger of rock-fall and debris flow. In 61 sites except the above sites, though there is no apparent danger, visitors need to be notified whether they pass through potential dangerous site. From future working using GIS technology and continuous monitoring for dangerous sites, small natural hazards can be predicted.

  6. Preliminary numerical investigation of bandwidth effects on CBET using the LPSE-CBET code

    Science.gov (United States)

    Bates, Jason; Myatt, Jason; Shaw, John; Weaver, James; Obenschain, Keith; Lehmberg, Robert; Obenschain, Steve

    2016-10-01

    Cross beam energy transfer (CBET) is a significant energy-loss mechanism for direct-drive implosions on the OMEGA laser facility. Recently, a working group that includes participants from the Laboratory for Laser Energetics (LLE) at the University of Rochester and the U.S. Naval Research Laboratory (NRL) was formed to investigate strategies for ameliorating the deleterious effects of CBET. As part of this collaboration, the wave-based code LPSE-CBET developed at LLE has been made available to researchers at NRL and is being used to study the feasibility of suppressing CBET through the enhancement of laser bandwidth by stimulated rotational Raman scattering (SRRS). In this poster, we present some preliminary results on this subject. In particular, we discuss initial efforts to evaluate mitigation levels of 4 discrete Stokes lines from SRRS in air and compare our findings with ray-based simulation results of wavelength shifted (-6Å ,0, +6Å) driver-lines on OMEGA. Work Supported by DoE/NNSA.

  7. Preliminary Experimental Investigation on MHD Power Generation Using Seeded Supersonic Argon Flow as Working Fluid

    Institute of Scientific and Technical Information of China (English)

    LI Yiwen; LI Yinghong; LU Haoyu; ZHU Tao; ZHANG Bailing; CHEN Feng; ZHAO Xiaohu

    2011-01-01

    This paper presents a preliminary experimental investigation on magnetohydrodynamic (MHD) power generation using seeded supersonic argon flow as working fluid.Helium and argon are used as driver and driven gas respectively in a shock tunnel.Equilibrium contact surface operating mode is used to obtain high temperature gas,and the conductivity is obtained by adding seed K2CO3 powder into the driven section.Under the conditions of nozzle inlet total pressure being 0.32 MPa,total temperature 6 504 K,magnetic field density about 0.5 T and nozzle outlet velocity 1 959 m/s,induction voltage and short-circuit current of the segmentation MHD power generation channel are measured,and the experimental results agree with theoretical calculations; the average conductivity is about 20 S/m calculated from characteristics of voltage and current.When load factor is 0.5,the maximum power density of the MHD power generation channel reaches 4.797 1 MW/m3,and the maximum enthalpy extraction rate is 0.34%.Finally,the principle and method of indirect testing for gas state parameters are derived and analyzed.

  8. Cognitive Behavioral Therapy for Maladaptive Perfectionism in Medical Students: A Preliminary Investigation.

    Science.gov (United States)

    Chand, Suma P; Chibnall, John T; Slavin, Stuart J

    2017-04-10

    Maladaptive perfectionism is associated with psychological distress and psychopathology. Medical students have been found to be particularly prone to maladaptive perfectionism. Recent research has indicated that Cognitive Behavioral Therapy (CBT) that targets unhealthy perfectionism leads to reductions in perfectionism and related distress. This preliminary investigation aimed to evaluate the efficacy of a CBT program directed at medical students who had significant levels of maladaptive perfectionism. The impact on associated psychological distress was also assessed. The study used a case series methodology with an A-B design plus follow-up. First-year medical students who screened positive for maladaptive perfectionism and consented for the study (N = 4) were assessed at baseline to evaluate the levels of maladaptive perfectionism, anxiety, and depression. They participated in an eight-session CBT program for reducing maladaptive perfectionism after a waiting period. Assessments were repeated post CBT and at 3- and 6-month follow up periods. Results indicated positive and durable effects on maladaptive perfectionism among program participants. The current research provides promising results for the use of CBT in at risk medical students with maladaptive perfectionism.

  9. Biosorption of {sup 241}Am by Rhizopus arrihizus: preliminary investigation and evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Liu Ning E-mail: 5416507@mail.sc.cninfo.net; Yang Yuanyou; Luo Shunzhong; Zhang Taiming; Jin Jiannan; Liao Jiali; Hua Xifeng

    2002-08-01

    The biosorption of {sup 241}Am from solution by a fungus--Rhizopus Arrihizus (R. arrihizus), and the effect of experimental conditions on the adsorption were investigated. The preliminary results showed that the biosorption of {sup 241}Am by R. arrihizus is very efficient. An average of more than 99% of the total {sup 241}Am was removed by R. arrihizus of 1.3 g/l (dry weight) from {sup 241}Am solutions of 5.6-111 MBq/l (44.3-877.2 {mu}g/l) (C{sub 0}), with adsorption capacities (W) of 4.2-79.4 MBq/g biomass (dry weight) (33.2-627.5 {mu}g/g). The biosorption equilibrium was achieved within 1 h and the optimum pH ranged from 1 to 3. No significant differences in {sup 241}Am biosorption were observed at 10-45 deg. C, or in solutions containing Au{sup 3+} or Ag{sup +}, even 2000 times above {sup 241}Am concentration. The relationship between concentrations and adsorption capacities of {sup 241}Am indicated that the {sup 241}Am biosorption by R. arrihizus obeys the Freundlich adsorption equation.

  10. Preliminary investigations of magnetic modulated nanoparticles for microwave breast cancer detection

    Directory of Open Access Journals (Sweden)

    Ley S.

    2015-09-01

    Full Text Available This paper investigates the potential of magnetic modulated iron oxide nanoparticles in terms of a contrast enhancement for Ultra-wideband (UWB breast imaging. The work is motivated by the low dielectric contrast between tumor and normal glandular/fibroconnective tissue. The influence of an external polarizing magnetic field on pure and coated magnetite nanoparticles is investigated in this contribution. Measurements were conducted using M-sequence UWB technology and an oil-gelatin phantom. It is shown that a coating, which is necessary for clinical use, results in a lower signal response, and thus leads to a lower detectability of magnetic modulated nanoparticles.

  11. Preliminary Examination of the Interpersonal Psychological Theory of Suicide in an Adolescent Clinical Sample.

    Science.gov (United States)

    Horton, Sarah E; Hughes, Jennifer L; King, Jessica D; Kennard, Betsy D; Westers, Nicholas J; Mayes, Taryn L; Stewart, Sunita M

    2016-08-01

    This study offers a preliminary examination of the Interpersonal-Psychological Theory of Suicide (IPTS; Joiner 2005) in an adolescent clinical sample. The IPTS offers a nuanced framework that has many conceptual and practical merits. Although this theory has a growing base of evidence among adults, it has yet to be tested in adolescents using direct measures of its central constructs. Participants were 147 adolescents (76.2 % girls) on an inpatient psychiatric unit, who completed measures of key IPTS constructs of thwarted belongingness, perceived burdensomeness, acquired capability for suicide, as well as depression severity, hopelessness, and severity of suicidal symptoms. Our findings were largely consistent with hypotheses derived from the IPTS: perceived burdensomeness, and at a marginal level, thwarted belongingness, were independently associated with current suicidal ideation. The thwarted belongingness by perceived burdensomeness interaction marginally distinguished between adolescents with passive and active suicidal ideation. Acquired capability for suicide was associated with recent suicidal intent. Examination of all three IPTS constructs simultaneously revealed main effects of each construct (with a marginal effect of thwarted belongingness), and interaction effects for thwarted belongingness by perceived burdensomeness, and thwarted belongingness by perceived burdensomeness by acquired capability for suicide in association with suicidal symptom severity. Sex, age, depression severity, and hopelessness were controlled in all analyses. This study offers strong, albeit preliminary, support of the IPTS in a clinical adolescent sample. Assessment of IPTS constructs may be useful in determining persistent risk for suicide attempt. Prospective tests of the theory, and extensions to intervention and prevention should be considered in future IPTS research.

  12. Clinical and Radiographic Evaluation of Immediate Loaded Dental Implants With Local Application of Melatonin: A Preliminary Randomized Controlled Clinical Trial.

    Science.gov (United States)

    El-Gammal, Mona Y; Salem, Ahmed S; Anees, Mohamed M; Tawfik, Mohamed A

    2016-04-01

    Immediate loading of dental implants in situations where low bone density exist, such as the posterior maxillary region, became possible recently after the introduction of biomimetic agents. This 1-year preliminary clinical trial was carried out to clinically and radiographically evaluate immediate-loaded 1-piece implants with local application of melatonin in the osteotomy site as a biomimetic material. 14 patients with missing maxillary premolars were randomized to receive 14 implants of 1-piece type that were subjected to immediate loading after 2 weeks of initial placement. Group I included 7 implants with acid-etched surface while group II included 7 implants with acid-etched surface combined with local application of melatonin gel at the osteotomy site. Patients were recalled for follow up at 1, 3, 6, and 12 months after loading. All implants were considered successful after 12 months of follow-up. Significant difference (P implant loading when considering the implant stability. At 1 and 3 months there were significant differences in the marginal bone level between the 2 groups. These results suggest that the local application of melatonin at the osteotomy site is associated with good stability and minimal bone resorption. However, more studies for longer follow-up periods are required to confirm the effect of melatonin hormone on osseointegration of dental implants.

  13. Bimanual elbow robotic orthoses: preliminary investigations on an impairment force feedback rehabilitation method

    Directory of Open Access Journals (Sweden)

    Gil eHerrnstadt

    2015-03-01

    Full Text Available Modern rehabilitation practices have begun integrating robots, recognizing their significant role in recovery. New and alternative stroke rehabilitation treatments are essential to enhance efficacy and mitigate associated health costs. Today’s robotic interventions can play a significant role in advancing rehabilitation. In addition, robots have an inherent ability to perform tasks accurately and reliably and are typically well suited to measure and quantify performance.Most rehabilitation strategies predominantly target activation of the paretic arm. However, bimanual upper limb rehabilitation research suggests potential in enhancing functional recovery. Moreover studies suggest limb coordination and synchronization can improve treatment efficacy.In this preliminary study, we aimed to investigate and validate our user-driven bimanual system in a reduced intensity rehab practice. A Bimanual Wearable Robotic Device (BWRD with a Master-Slave configuration for the elbow joint was developed to carry out the investigation. The BWRD incorporates position and force sensors for which respective control loops are implemented, and offers varying modes of operation ranging from passive to active training. The proposed system enables the perception of the movements, as well as the forces applied by the hemiparetic arm, with the non-hemiparetic arm. Eight participants with chronic unilateral stroke were recruited to participate in a total of three one-hour sessions per participant, delivered in a week. Participants underwent pre and post training functional assessments along with proprioceptive measures. The post assessment was performed at the end of the last training session.The protocol was designed to engage the user in an assortment of static and dynamic arm matching and opposing tasks. The training incorporates force feedback movements, force feedback positioning, and force matching tasks with same and opposite direction movements. We are able to

  14. LOD 1 VS. LOD 2 - Preliminary Investigations Into Differences in Mobile Rendering Performance

    Science.gov (United States)

    Ellul, C.; Altenbuchner, J.

    2013-09-01

    The increasing availability, size and detail of 3D City Model datasets has led to a challenge when rendering such data on mobile devices. Understanding the limitations to the usability of such models on these devices is particularly important given the broadening range of applications - such as pollution or noise modelling, tourism, planning, solar potential - for which these datasets and resulting visualisations can be utilized. Much 3D City Model data is created by extrusion of 2D topographic datasets, resulting in what is known as Level of Detail (LoD) 1 buildings - with flat roofs. However, in the UK the National Mapping Agency (the Ordnance Survey, OS) is now releasing test datasets to Level of Detail (LoD) 2 - i.e. including roof structures. These datasets are designed to integrate with the LoD 1 datasets provided by the OS, and provide additional detail in particular on larger buildings and in town centres. The availability of such integrated datasets at two different Levels of Detail permits investigation into the impact of the additional roof structures (and hence the display of a more realistic 3D City Model) on rendering performance on a mobile device. This paper describes preliminary work carried out to investigate this issue, for the test area of the city of Sheffield (in the UK Midlands). The data is stored in a 3D spatial database as triangles and then extracted and served as a web-based data stream which is queried by an App developed on the mobile device (using the Android environment, Java and OpenGL for graphics). Initial tests have been carried out on two dataset sizes, for the city centre and a larger area, rendering the data onto a tablet to compare results. Results of 52 seconds for rendering LoD 1 data, and 72 seconds for LoD 1 mixed with LoD 2 data, show that the impact of LoD 2 is significant.

  15. Preliminary Investigation on Generation of Electricity Using Micro Wind Turbines Placed on A Car

    Directory of Open Access Journals (Sweden)

    Yogendra Chaudhary

    2017-03-01

    Full Text Available Wind energy is one of the prominent resources for renewable energy and it is traditionally extracted using stationary wind turbines. However, it can also be extracted using mini or micro wind turbines on a moving body, such as an automobile, while cruising at high speeds on freeways. If the electricity is produced using air flowing around the vehicle without affecting aerodynamic performance of the vehicle, it can be used to charge up the battery or power up additional accessories of the vehicle. For the first time, in the present work, a preliminary investigation was carried out to generate electricity by utilizing air flow on a moving car. Initially, a correlation between the car speed and wind velocity was established using an anemometer. Placing a set of two micro wind turbines along with two micro generators on the rear end of the car trunk, the present study investigated the feasibility of generating electricity from these micro wind turbines while evaluating the effect of drag force on the performance of the car through the experimental approach and computational fluid dynamics (CFD simulations. Both approaches confirmed negligible effect of drag force on the vehicle performance in terms of gas mileage and changes in drag coefficient values. Following these studies, the micro wind turbines were also tested for electricity generation at various cruising speeds of the car ranging from 50 to 80 mph on the freeways. The voltage and power generated always showed an increasing trend with increasing the car speed, however they saturated when a cut off limit was setup with the voltage controllers. A maximum voltage of 3.5 V and a maximum current of 0.8 A were generated by each micro wind turbine when a cut off limit was used along with a load consisting of four LED bulbs in parallel with 3.5 V and 0.2 A rating each. On the other hand, when the tests were repeated without using the cut-off limit, a maximum voltage of 18.91 V and a maximum current

  16. Hazards by shock waves during explosive eruptions: preliminary results of experimental investigations.

    Science.gov (United States)

    Scolamacchia, Teresa; Alatorre Ibarguengoïtia, Miguel; Spieler, Oliver; Dingwell, Donald B.

    2010-05-01

    A recent study (Scolamacchia and Shouwenaars, 2009) investigated the nature of microscopic craters on the steel surface of a basketball pole left standing in one of the villages destroyed by the 1982 eruption of El Chichón volcano. The craters were attributed to the impacts of ash particles (70-280 μm) accelerated by shock waves due to an efficient momentum coupling with a gas phase, such that a sudden expansion of the gas, caused by shock wave propagation, drag the particles up to speeds of 710 to 980 m/s. Several open questions existed on this kind of phenomena. Preliminary tests were performed to investigate the correlation between particle size and the high velocities calculated, based on inner deformation of the steel and crater geometry. We used a shock tube apparatus consisting of a high-pressure (HP) steel autoclave, pressurized with Ar gas, and a low pressure (LP) tank at atmospheric conditions. We used ash and lapilli bulk samples from El Chichón trachyandesites, and lapilli with random irregular shapes obtained by crushing and abrading dacitic blocks from pyroclastic flow deposits of Unzen volcano. The samples were placed inside an autoclave at ambient T and P, located between the HP autoclave and the LP tank. Steel plates (same type of the original impacted material), were fixed to the LP tank walls, 10 cm above the autoclave that contained the samples. Shock waves were generated by the sudden decompression of the Ar gas due to the systematical failure of a diaphragm (which separate the LP from the HP section). Air expansion accelerated the particles from below toward the steel plate. The speed of the particles was measured using a system of 4 copper wires conducting an electric signal. The signals dropped when the particles reached the wires. We used low pressure ranges (3.1 to 9.8 MPa) for all experimental runs, obtaining a range of particles velocities between 40 and 257 m/s. These velocities can be attained by pyroclastic density currents. Higher

  17. The value of formal clinical research training in initiating a career as a clinical investigator.

    Science.gov (United States)

    Kapoor, Karan; Wu, Bechien U; Banks, Peter A

    2011-12-01

    The aim of this study was to determine whether formal clinical research training is of value in the initiation of a successful career as a clinical investigator. We conducted a retrospective review of the career choices of all 25 fellows who entered the Academic Clinical Research Track at Brigham and Women's Hospital since its inception in 1995 and examined the impact of formal clinical research training during their fellowship on their career choice. The primary measure of a successful career as a clinical investigator was the obtainment of external funding for clinical research within 3 years of completion of fellowship. Thirteen of the 25 fellows (52%) received a Master of Public Health (MPH) degree at the Harvard School of Public Health during their fellowship. Ten of these 13 fellows (77%) obtained external funding for clinical research within 3 years of completion of their fellowship. None of the 5 fellows who had already obtained an MPH degree prior to their fellowship and none of the 7 fellows who completed a 7-week summer Program in Clinical Effectiveness but did not complete an MPH degree attempted to receive external funding for clinical research within 3 years of completion of their fellowship. We conclude that formal clinical research training culminating in an MPH degree was extremely valuable in the initiation of a successful career as a clinical investigator.

  18. A dual-modality photoacoustic and ultrasound imaging system for noninvasive sentinel lymph node detection: preliminary clinical results

    Science.gov (United States)

    Erpelding, Todd N.; Garcia-Uribe, Alejandro; Krumholz, Arie; Ke, Haixin; Maslov, Konstantin; Appleton, Catherine; Margenthaler, Julie; Wang, Lihong V.

    2014-03-01

    Sentinel lymph node biopsy (SLNB) has emerged as an accurate, less invasive alternative to axillary lymph node dissection, and it has rapidly become the standard of care for patients with clinically node-negative breast cancer. The sentinel lymph node (SLN) hypothesis states that the pathological status of the axilla can be accurately predicted by determining the status of the first (i.e., sentinel) lymph nodes that drain from the primary tumor. Physicians use radio-labeled sulfur colloid and/or methylene blue dye to identify the SLN, which is most likely to contain metastatic cancer cells. However, the surgical procedure causes morbidity and associated expenses. To overcome these limitations, we developed a dual-modality photoacoustic and ultrasound imaging system to noninvasively detect SLNs based on the accumulation of methylene blue dye. Ultimately, we aim to guide percutaneous needle biopsies and provide a minimally invasive method for axillary staging of breast cancer. The system consists of a tunable dye laser pumped by a Nd:YAG laser, a commercial ultrasound imaging system (Philips iU22), and a multichannel data acquisition system which displays co-registered photoacoustic and ultrasound images in real-time. Our clinical results demonstrate that real-time photoacoustic imaging can provide sensitive and specific detection of methylene blue dye in vivo. While preliminary studies have shown that in vivo detection of SLNs by using co-registered photoacoustic and ultrasound imaging is feasible, further investigation is needed to demonstrate robust SLN detection.

  19. Preliminary investigation of self-as-context in people with fibromyalgia.

    Science.gov (United States)

    Yu, Lin; Norton, Sam; Almarzooqi, Sarah; McCracken, Lance M

    2017-08-01

    Acceptance and commitment therapy (ACT), based on the Psychological Flexibility (PF) model, has been recently applied to fibromyalgia (FM), and appeared effective in improving functioning. However, evidence for some of the processes within the PF model, self-as-context (SAC) in particular, is lacking within this population. The current study validates a measure of SAC, the Self Experiences Questionnaire (SEQ), and preliminarily investigates the role of SAC in relation to functioning in FM. Participants (N = 298, 93.3% women) self-reporting a diagnosis of FM were recruited via the Internet and completed an online survey. Measures included pain, pain acceptance and SAC, as processes, and pain interference, work and social adjustment, depression and depression-related interference, as outcomes. Confirmatory factor analysis of the SEQ suggested a bi-factor structure, with a general factor underlying all items and two sub-factors, self-as-distinction and self-as-observer (χ2 = 46.55, p = .06, comparative fit index (CFI) = .99, Tucker-Lewis Index (TLI) = .99, root mean square error of approximation (RMSEA) = .04). Component factors showed good reliability, Cronbach's α = .90, and construct validity, supported by significant Pearson's correlations between SEQ scores, acceptance and outcomes (r = -.14 to -.33). In multiple regression analyses, SEQ scores significantly predicted pain-related interference (β = -.17, p < .05), work and social adjustment (β = -.14, p < .05) and depression (β = -.21, p < .01), but not depression-related interference, after controlling for pain, but only significantly predicted depression after controlling pain acceptance. These preliminary results show potentially important associations between SAC and functioning in people with FM.

  20. [Preliminary investigation on the pathogeny, diagnosis and treatment of chondromalacia patella].

    Science.gov (United States)

    Ye, Q B; Wu, Z H; Wang, Y P; Lin, J; Qiu, G X

    2001-04-01

    This paper presents the preliminary investigation on chondromalacia patella at our department in recent years. A random cluster sampling survey covering 2743 normal persons was carried out. The prevalence rate is 36.2%. It was found that, applying transmission electron microscope and immunohistochemical methods on to cartilage tissues of the abnormal region, articular cartilage necrosis was in direct proportion with the abnormal pressure, while the restoration capability of local chondrocytes was in inverse proportion with pathological changes and the pressure. The chondromalacia patella was produced by repeated abnormal stress acting on the cartilage. The stress derived from the uncongruency and the decreasing in the contact area of patellofemoral joint when the subluxation or tilt of patellae was caused by the abnormal anatomical and biomechanical relationship. The initial lesion was at the matrix of cartilage, the collagen network was disrupted, then proteoglycan was lost. The microenvironment of chondrocytes was changed with degradation of matrix. So the chondrocytes became degenerative and necrosis from superficial to deep layer, then feed back the matrix again. Finally, the total cartilage layer might disappear, and the bone under cartilage might proliferate. At late stage, the cartilage was completely destroyed and had no self-restorative ability. Therefore, early diagnosis and treatment are necessary. It is highly suggested axis radiograph of the knee with the tibiae tuberositas localization are helpful to early diagnosis. Furthermore, JKY-Muscle Rehabilitation Instrument is invented for non-operative therapy. It enhances muscle power by selective training of the vastus medialis muscle using electrical stimulator to relieve pain and correct subluxation of patella with 90% efficiency (63% of excellent-effective rate). In late stage, patellofemoral replacement is recommended. The excellent-effective rate is 86.3%.

  1. Preliminary experimental investigation of a complex dual-band high power microwave source

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Xiaoping, E-mail: zhangxiaoping@nudt.edu.cn; Li, Yangmei; Li, Zhiqiang; Zhong, Huihuang; Qian, Baoliang [College of Optoelectronic Science and Engineering, National University of Defense Technology, Changsha 410073 (China)

    2015-10-15

    In order to promote the power conversion efficiency of a magnetically insulated transmission line oscillator (MILO) and obtain microwaves in dual bands, an axially extracted C-band virtual cathode oscillator (VCO) with multiple resonant cavities is introduced to partially utilize the load current of an S-band MILO. The formed novel dual-band high power microwave source called MILO and VCO is investigated with simulation and experimentally. A dual-band radiation antenna is designed to effectively radiate microwaves generated by the MILO and the VCO, respectively, while avoiding them being influenced by the microwave reflection and diffraction. The preliminary experimental results measured by the dual-band diagnostic system show that both the MILO and the VCO operate normally under repeated shots. A microwave of 2.1 GHz, 1.70 GW is generated from the MILO and a 0.37 GW microwave at frequencies of 4.1 GHz and 3.8 GHz is generated from the VCO under the condition of about 440 kV and 35 kA. Compared with a single MILO (10.6%), a MILO and VCO achieves higher total power and efficiency (13.4%) in both S and C bands, indicating that the load current of the MILO partially couples into the beam-wave interaction in the VCO and then contributes to the output microwaves. However, more works are needed regarding the spectrum purification of the VCO and promotion of the output power of both the MILO and the VCO.

  2. Disrupted Tactile Acuity in People With Achilles Tendinopathy: A Preliminary Case-Control Investigation.

    Science.gov (United States)

    Debenham, James; Butler, Prue; Mallows, Adrian; Wand, Benedict M

    2016-12-01

    Study Design Controlled laboratory study, preliminary case-control design. Background The mechanisms that contribute to Achilles tendinopathy remain poorly understood. The disparity between pain experience and peripheral pathology demonstrated in patients with Achilles tendinopathy suggests that changes in central nervous system function may be involved. Objectives To investigate whether lower-limb tactile acuity is impaired in people with nonacute Achilles tendinopathy. Methods Thirteen consecutive participants with nonacute midportion Achilles tendinopathy and 13 healthy controls were enrolled. Two-point discrimination thresholds over the affected Achilles tendon, unaffected tendon, and tendon of healthy controls were evaluated. Independent and dependent t tests were used to compare group means. Results Two-point discrimination distance over the affected limb in participants with Achilles tendinopathy was significantly increased when compared to the unaffected limb (mean difference, 11.7 mm; 95% confidence interval [CI]: 1.9, 21.5; P = .02) and to healthy controls (mean difference, 13.1 mm; 95% CI: 1.6, 24.6; P = .03). There was no significant difference between the healthy controls and the unaffected side in people with Achilles tendinopathy (mean difference, 1.4 mm; 95% CI: -7.9, 5.1; P = .66). Conclusion These data provide the first evidence of reduced 2-point discrimination over the affected tendon in patients with Achilles tendinopathy. Further research is needed to determine the cause for the change in tactile acuity. J Orthop Sports Phys Ther 2016;46(12):1061-1064. Epub 30 Oct 2016. doi:10.2519/jospt.2016.6514.

  3. Clinical investigations for SUS, the Brazilian public health system

    Directory of Open Access Journals (Sweden)

    Ana Patrícia de Paula

    Full Text Available CONTEXT AND OBJECTIVE: Scientific and technological development is crucial for advancing the Brazilian health system and for promoting quality of life. The way in which the Brazilian Ministry of Health has supported clinical research to provide autonomy, self-sufficiency, competitiveness and innovation for the healthcare industrial production complex, in accordance with the National Policy on Science, Technology and Innovation in Healthcare, was analyzed. DESIGN AND SETTING: Descriptive investigation, based on secondary data, conducted at the Department of Science and Technology, Ministry of Health. METHODS: The Ministry of Health's research management database, PesquisaSaúde, was analyzed from 2002 to 2009, using the key word "clinical research" in the fields "primary sub-agenda" or "secondary sub-agenda". The 368 projects retrieved were sorted into six categories: basic biomedical research, preclinical studies, expanded clinical research, clinical trials, infrastructure support and health technology assessment. From a structured review on "clinical research funding", results from selected countries are presented and discussed. RESULTS: The amount invested was R$ 140 million. The largest number of projects supported "basic biomedical research", while the highest amounts invested were in "clinical trials" and "infrastructure support". The southeastern region had the greatest proportion of projects and financial resources. In some respects, Brazil is ahead of other BRICS countries (Russia, India, China and South Africa, especially with regard to establishing a National Clinical Research Network. CONCLUSION: The Ministry of Health ensured investments to encourage clinical research in Brazil and contributed towards promoting cohesion between investigators, health policies and the healthcare industrial production complex.

  4. Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results

    Science.gov (United States)

    Bigio, Irving J.; Brown, Stephen G.; Briggs, Gavin M.; Kelley, Christine; Lakhani, Sunil; Pickard, David; Ripley, Paul M.; Rose, Ian; Saunders, Christobel

    2000-04-01

    We report on the first stages of a clinical study designed to test elastic-scattering spectroscopy, medicated by fiberoptic probes, for three specific clinical applications in breast-tissue diagnosis: (1) a transdermal-needle (interstitial) measurement for instant diagnosis with minimal invasiveness similar to fine-needle aspiration but with sensitivity to a larger tissue volume, (2) a hand-held diagnostic probe for use in assessing tumor/resection margins during open surgery, and (3) use of the same probe for real-time assessment of the `sentinel' node during surgery to determine the presence or absence of tumor (metastatic). Preliminary results from in vivo measurements on 31 women are encouraging. Optical spectra were measured on 72 histology sites in breast tissue, and 54 histology sites in sentinel nodes. Two different artificial intelligence methods of spectral classification were studied. Artificial neural networks yielded sensitivities of 69% and 58%, and specificities of 85% and 93%, for breast tissue and sentinel nodes, respectively. Hierarchical cluster analysis yielded sensitivities of 67% and 91%, and specificities of 79% and 77%, for breast tissue and sentinel nodes, respectively. These values are expected to improve as the data sets continue to grow and more sophisticated data preprocessing is employed. The study will enroll up to 400 patients over the next two years.

  5. A preliminary clinical evaluation of external snehan and asanas in the patients of sciatica

    Science.gov (United States)

    Singh, Akhilesh K; Singh, Om P

    2013-01-01

    Lower back pain radiating to either on one leg or both legs along the course of sciatic nerve is a common ailment in the clinical practice, this type of peculiar symptomatology is termed as "Sciatica" in modern medicine. The medical treatment is unsatisfactory for both the patient and the neurosurgeons, as the surgical treatment has its own hazards and the cost of the surgical procedure and medical treatment is prohibitory to most of the Indian patients. Hence, most of the patients present themselves to the practitioners of Indian medicines like Ayurveda and yoga. This study was designed to evaluate the preliminary clinical effects of Bahya Snehan and Asanas in the patients of sciatica. This was a prospective randomized active control trial. A total of 60 participants showing classical symptoms of Sciatica between 18 and 65 years of age were randomly assigned to receive Ayurvedic or Yogic measure. One group received Snehan (external) with Bhujang and Shalabh Asana while another group received Bhujang and Salabh Asana only. Both groups practiced supervised intervention for 4 weeks. The signs and symptoms like Katishool (pain), tenderness, Stambha (rigidity), difficulty in walking, pain on bending forward were graded and interpreted at the end of the trail Significant improvement was observed in both groups before and after external Snehan with Bhujang and Shalabh Asana and in another group Bhujang and Salabh Asana only. Conclusions: Both groups, one with Snehan with asanas and the second with asanas only showed significant improvement in the patients of sciatica (Gridhrasi). PMID:23439799

  6. A preliminary clinical evaluation of external snehan and asanas in the patients of sciatica

    Directory of Open Access Journals (Sweden)

    Akhilesh K Singh

    2013-01-01

    Full Text Available Lower back pain radiating to either on one leg or both legs along the course of sciatic nerve is a common ailment in the clinical practice, this type of peculiar symptomatology is termed as "Sciatica" in modern medicine. The medical treatment is unsatisfactory for both the patient and the neurosurgeons, as the surgical treatment has its own hazards and the cost of the surgical procedure and medical treatment is prohibitory to most of the Indian patients. Hence, most of the patients present themselves to the practitioners of Indian medicines like Ayurveda and yoga. This study was designed to evaluate the preliminary clinical effects of Bahya Snehan and Asanas in the patients of sciatica. This was a prospective randomized active control trial. A total of 60 participants showing classical symptoms of Sciatica between 18 and 65 years of age were randomly assigned to receive Ayurvedic or Yogic measure. One group received Snehan (external with Bhujang and Shalabh Asana while another group received Bhujang and Salabh Asana only. Both groups practiced supervised intervention for 4 weeks. The signs and symptoms like Katishool (pain, tenderness, Stambha (rigidity, difficulty in walking, pain on bending forward were graded and interpreted at the end of the trail Significant improvement was observed in both groups before and after external Snehan with Bhujang and Shalabh Asana and in another group Bhujang and Salabh Asana only. Conclusions: Both groups, one with Snehan with asanas and the second with asanas only showed significant improvement in the patients of sciatica (Gridhrasi.

  7. An Algorithm for Glaucoma Screening in Clinical Settings and Its Preliminary Performance Profile

    Directory of Open Access Journals (Sweden)

    S-Farzad Mohammadi

    2013-01-01

    Full Text Available Purpose: To devise and evaluate a screening algorithm for glaucoma in clinical settings. Methods: Screening included examination of the optic disc for vertical cupping (≥0.4 and asymmetry (≥0.15, Goldmann applanation tonometry (≥21 mmHg, adjusted or unadjusted for central corneal thickness, and automated perimetry. In the diagnostic step, retinal nerve fiber layer imaging was performed using scanning laser polarimetry. Performance of the screening protocol was assessed in an eye hospital-based program in which 124 non-physician personnel aged 40 years or above were examined. A single ophthalmologist carried out the examinations and in equivocal cases, a glaucoma subspecialist′s opinion was sought. Results: Glaucoma was diagnosed in six cases (prevalence 4.8%; 95% confidence interval, 0.01-0.09 of whom five were new. The likelihood of making a definite diagnosis of glaucoma for those who were screened positively was 8.5 times higher than the estimated baseline risk for the reference population; the positive predictive value of the screening protocol was 30%. Screening excluded 80% of the initial population. Conclusion: Application of a formal screening protocol (such as our algorithm or its equivalent in clinical settings can be helpful in detecting new cases of glaucoma. Preliminary performance assessment of the algorithm showed its applicability and effectiveness in detecting glaucoma among subjects without any visual complaint.

  8. Preliminary investigation of lithium for mood disorder symptoms in children and adolescents with autism spectrum disorder.

    Science.gov (United States)

    Siegel, Matthew; Beresford, Carol A; Bunker, Madisun; Verdi, Mary; Vishnevetsky, Donna; Karlsson, Cassie; Teer, Olivia; Stedman, Amy; Smith, Kahsi A

    2014-09-01

    Children with autism spectrum disorder (ASD) have higher rates of comorbid psychiatric disorders, including mood disorders, than the general child population. Although children with ASD may experience irritability (aggression, self-injury, and tantrums), a portion also experience symptoms that are typical of a mood disorder, such as euphoria/elevated mood, mania, hypersexuality, paranoia, or decreased need for sleep. Despite lithium's established efficacy in controlling mood disorder symptoms in the neurotypical population, lithium has been rarely studied in children with ASD. We performed a retrospective chart review of 30 children and adolescents diagnosed with ASD by the Diagnostic and Statistical Manual of Mental Disorders, 4th ed., Text Revision (DSM-IV-TR) criteria who were prescribed lithium in order to assess target symptoms, safety, and tolerability. Clinical Global Impressions - Improvement (CGI-I) ratings were performed by two board-certified child psychiatrists with expertise in ASD. CGI-I scores were dichotomized into "improved" (CGI-I score of 1 or 2) or "not improved" (CGI-I score ≥3). Forty-three percent of patients who received lithium were rated as "improved" on the CGI-I. Seventy-one percent of patients who had two or more pretreatment mood disorder symptoms were rated as "improved." The presence of mania (p=0.033) or euphoria/elevated mood (p=0.041) were the pretreatment symptoms significantly associated with an "improved" rating. The mean lithium blood level was 0.70 mEq/L (SD=0.26), and the average length of lithium treatment was 29.7 days (SD=23.9). Forty-seven percent of patients were reported to have at least one side effect, most commonly vomiting (13%), tremor (10%), fatigue (10%), irritability (7%), and enuresis (7%). This preliminary assessment of lithium in children and adolescents with ASD suggests that lithium may be a medication of interest for those who exhibit two or more mood disorder symptoms, particularly mania or euphoria

  9. 76 FR 30175 - Draft Guidance for Clinical Investigators, Industry, and FDA Staff: Financial Disclosure by...

    Science.gov (United States)

    2011-05-24

    ... Investigators, Industry, and FDA Staff: Financial Disclosure by Clinical Investigators; Availability AGENCY... FDA Staff: Financial Disclosure by Clinical Investigators.'' This draft guidance is intended to assist... governing financial disclosure by clinical investigators. This guidance provides FDA's responses to the...

  10. Preliminary Geotechnical Investigation of Two Basaltic Landslide Sites in Mauritius, Offshore Africa

    Science.gov (United States)

    Bhoopendra, D.; Fukuoka, H.; Kuwano, T.; Ichikawa, K.

    2016-12-01

    Landslide hazards in developing areas in Mauritius became a great challenge as well as a fundamental concern for the government and the citizen of the country. In recent years, landslide disasters have caused losses of both public and private properties. In 2005, a large-scale landslide at Chitrakoot affected 54 houses and infrastructures, and it was reactivated in 2006, damaging another 14 houses. Vallee Pitot landslide is frequently reactivated in these years and threatening several houses in the densely-populated zone. Being of volcanic origin, Mauritius has observed dramatic and quick weathering of the soil which may partly contribute to creating landslide-prone geo-environment. This study focuses on the preliminary geotechnical investigation of the two basaltic landslide areas in Mauritius. A recent investigation was conducted jointly by JICA (Japan International Cooperation Agency) and Ministry of Public Infrastructure and Land Transport of Government of Mauritius on both sites from 2012 to 2015 to survey the landslide surface and to implement countermeasures works.Both sites are located in the highly populated area in the capital city of Mauritius.The geological features of the sites were studied with the borehole core logging data obtained from 6 boreholes and it was found that possible sliding surface was observed in the colluvium layer consisting of gravels and stiff silty-clays, at depths from 6 to 10 m below the ground surface. The rate of landslide movement during heavy rainfall amount exceeding 100 mm/hr was elaborated with past records of extensometers installed on these sites. Colluvium samples from both sites of the same characteristics with the sliding surface were tested in the ring shear apparatus in Japan under different normal stresses reducing from 300 kPa to 50 kPa step-wise at a shear velocity of 0.02 mm/min under drained condition to obtain the residual friction angle (φ) and the cohesion (c). Obtained residual friction angle and cohesion

  11. Preliminary Investigation Of Emirati Women Entrepreneurship In The UAE Motivating Factors Challenges And Government Initiatives

    Directory of Open Access Journals (Sweden)

    Mohammad Rehan Shahnawaz

    2015-08-01

    Full Text Available Abstract Purpose The purpose of this research is to conduct an in depth preliminary investigation of the Emirati Women Entrepreneurship in the UAE in terms of the factors motivating the Emirati women to engage in the entrepreneurial activities challenges and issues faced by them in that process and initiatives taken by the government of UAE in overcoming those challenges and in encouraging promoting and safeguarding their interests. Methodology This research is an exploratory one due to the fact that the topic of the research strongly requires an in depth analysis or investigation of the underlying motivating factors challenges and issues and the government initiatives taken on behalf of Emirati women entrepreneurs. The research has used qualitative content analysis technique in which the existing literature secondary data on women and Emirati women entrepreneurship was gathered and discussed to serve the purpose of the research such as from other published researches internet searches and books. DiscussionsFindings The research explored an array of factors motivating the Emirati women towards entrepreneurship and the challenges and issues they come across in that process. The motivating factors were divided into positive and negative factors with main emphasis on the positive factors. Among the positive motivating factors were the Emiratization change in the organizational culture and beliefs relaxation of social and cultural structures inde-pendence and self-improvement and development. The negative motivating factors were the necessity unacceptable working conditions inflexible work hours wage gap between males and females and job frustrations. The major challenges and issues they usually come across are traditions cultural religious and social restrictions lack of managerial experience and basic business knowledge low self-confidence and determination male prejudice stereotyping and preconception minimal networking gender based promotional

  12. Bimanual elbow robotic orthoses: preliminary investigations on an impairment force-feedback rehabilitation method.

    Science.gov (United States)

    Herrnstadt, Gil; Alavi, Nezam; Randhawa, Bubblepreet Kaur; Boyd, Lara A; Menon, Carlo

    2015-01-01

    Modern rehabilitation practices have begun integrating robots, recognizing their significant role in recovery. New and alternative stroke rehabilitation treatments are essential to enhance efficacy and mitigate associated health costs. Today's robotic interventions can play a significant role in advancing rehabilitation. In addition, robots have an inherent ability to perform tasks accurately and reliably and are typically well suited to measure and quantify performance. Most rehabilitation strategies predominantly target activation of the paretic arm. However, bimanual upper-limb rehabilitation research suggests potential in enhancing functional recovery. Moreover, studies suggest that limb coordination and synchronization can improve treatment efficacy. In this preliminary study, we aimed to investigate and validate our user-driven bimanual system in a reduced intensity rehab practice. A bimanual wearable robotic device (BWRD) with a Master-Slave configuration for the elbow joint was developed to carry out the investigation. The BWRD incorporates position and force sensors for which respective control loops are implemented, and offers varying modes of operation ranging from passive to active training. The proposed system enables the perception of the movements, as well as the forces applied by the hemiparetic arm, with the non-hemiparetic arm. Eight participants with chronic unilateral stroke were recruited to participate in a total of three 1-h sessions per participant, delivered in a week. Participants underwent pre- and post-training functional assessments along with proprioceptive measures. The post-assessment was performed at the end of the last training session. The protocol was designed to engage the user in an assortment of static and dynamic arm matching and opposing tasks. The training incorporates force-feedback movements, force-feedback positioning, and force matching tasks with same and opposite direction movements. We are able to suggest

  13. Preliminary Evaluation of the Effect of Investigational Ebola Virus Disease Treatments on Viral Genome Sequences.

    Science.gov (United States)

    Whitmer, Shannon L M; Albariño, César; Shepard, Samuel S; Dudas, Gytis; Sheth, Mili; Brown, Shelley C; Cannon, Deborah; Erickson, Bobbie R; Gibbons, Aridth; Schuh, Amy; Sealy, Tara; Ervin, Elizabeth; Frace, Mike; Uyeki, Timothy M; Nichol, Stuart T; Ströher, Ute

    2016-10-15

     Several patients with Ebola virus disease (EVD) managed in the United States have received ZMapp monoclonal antibodies, TKM-Ebola small interfering RNA, brincidofovir, and/or convalescent plasma as investigational therapeutics.  To investigate whether treatment selected for Ebola virus (EBOV) mutations conferring resistance, viral sequencing was performed on RNA extracted from clinical blood specimens from patients with EVD following treatment, and putative viral targets were analyzed.  We observed no major or minor EBOV mutations within regions targeted by therapeutics.  This small subset of patients and clinical specimens suggests that evolution of resistance is not a direct consequence of antiviral treatment. As EVD antiviral treatments are introduced into wider use, it is essential that continuous viral full-genome surveillance is performed, to monitor for the emergence of escape mutations. Published by Oxford University Press for the Infectious Diseases Society of America 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.

  14. Preliminary Geotechnical Investigation of Two Basaltic Landslide Sites in Mauritius, Offshore Africa

    Science.gov (United States)

    Dabycharun, Bhoopendra; Kuwano, Takeshi; Ichikawa, Kensuke; Fukuoka, Hiroshi

    2016-04-01

    Landslide hazards in developing areas in Mauritius became a great challenge as well as a fundamental concern for the government and the citizen of the country. In recent years, landslide disasters have caused losses of both public and private properties. In 2005, a large-scale landslide at Chitrakoot affected 54 houses and infrastructures, and it was reactivated in 2006, damaging another 14 houses. Vallee Pitot landslide is frequently reactivated in these years and threatening several houses in densely-populated zone. Although the long-term annual precipitation show slightly decreasing trend, number of tropical cyclone over Mauritius is clearly increasing at least in the past 3 decades. Being of volcanic origin, Mauritius has observed dramatic and quick weathering of the soil which may partly contributes to creating landslide-prone geo-environment. This study focuses on the preliminary geotechnical investigation of the above-mentioned two basaltic landslide areas in Mauritius. Recent investigation was conducted jointly by JICA (Japan International Cooperation Agency) and Ministry of Public Infrastructure and Land Transport of Government of Mauritius on both sites from 2012 to 2015 to survey the landslide surface and to implement countermeasures works. In the field investigation, aerial photo interpretation was used to investigate the zone of cracks and scarps for both sites. The landslide areas for Chitrakoot and Vallee Pitot were estimated to 1.8 km2 and 5,000 m2 respectively. Both sites are located in the highly populated area in the capital city of Mauritius. The geological features of the sites were studied with the borehole core logging data obtained from 6 boreholes and it was found that possible sliding surface was observed in the colluvium layer consisting of gravels and stiff silty-clays, at depths from 6 to 10 m below the ground surface. The rate of landslide movement during heavy rainfall amount exceeding 100 mm/hr was elaborated with past records of

  15. Characterising Developmental Language Impairment in Serbian-Speaking Children: A Preliminary Investigation

    Science.gov (United States)

    Vukovic, Mile; Stojanovik, Vesna

    2011-01-01

    The aim of the article is to provide preliminary data on the use of auxiliaries and clitics in Serbian-speaking children with developmental language impairment. Two groups of children (a group of 30 children with developmental language impairment and a group of 30 typically developing children) aged between 48 and 83 months and matched on IQ took…

  16. A Preliminary Investigation into the Search Behaviour of Users in a Collection of Digitized Broadcast Audio

    DEFF Research Database (Denmark)

    Lund, Haakon; Skov, Mette; Larsen, Birger;

    2014-01-01

    An increasing number of large digitized audio-visual collections within digital humanities have recently been made available for users. Often access to digitized audio-visual collections is hampered by little and inconsistent metadata. This paper presents the preliminary findings from a study of ...

  17. Preliminary Investigation of the 1991 Medical College Admission Test Factor Structure.

    Science.gov (United States)

    Li, Weichang; Mitchell, Karen J.

    A substantially revised Medical College Admission Test (MCAT) was introduced in spring 1991. The new examination is designed to assess critical thinking skills, basic concepts and problem solving facility in science, and writing skills. This paper reports preliminary findings on the factor structure of the revised MCAT, which consists of four…

  18. A history of the American Society for Clinical Investigation.

    Science.gov (United States)

    Howell, Joel D

    2009-04-01

    One hundred years ago, in 1909, the American Society for Clinical Investigation (ASCI) held its first annual meeting. The founding members based this new society on a revolutionary approach to research that emphasized newer physiological methods. In 1924 the ASCI started a new journal, the Journal of Clinical Investigation. The ASCI has also held an annual meeting almost every year. The society has long debated who could be a member, with discussions about whether members must be physicians, what sorts of research they could do, and the role of women within the society. The ASCI has also grappled with what else the society should do, especially whether it ought to take a stand on policy issues. ASCI history has reflected changing social, political, and economic contexts, including several wars, concerns about the ethics of biomedical research, massive increases in federal research funding, and an increasingly large and specialized medical environment.

  19. A history of the American Society for Clinical Investigation

    Science.gov (United States)

    Howell, Joel D.

    2009-01-01

    One hundred years ago, in 1909, the American Society for Clinical Investigation (ASCI) held its first annual meeting. The founding members based this new society on a revolutionary approach to research that emphasized newer physiological methods. In 1924 the ASCI started a new journal, the Journal of Clinical Investigation. The ASCI has also held an annual meeting almost every year. The society has long debated who could be a member, with discussions about whether members must be physicians, what sorts of research they could do, and the role of women within the society. The ASCI has also grappled with what else the society should do, especially whether it ought to take a stand on policy issues. ASCI history has reflected changing social, political, and economic contexts, including several wars, concerns about the ethics of biomedical research, massive increases in federal research funding, and an increasingly large and specialized medical environment. PMID:19348041

  20. 论初查工作的改进与规范%On the improvement and specification of preliminary investigation

    Institute of Scientific and Technical Information of China (English)

    王洪明; 张加昕

    2011-01-01

    The preliminary investigation work,as an important part of prefiling of prosecutors,has its own particularity and plays a key and decisive role in whether filing the case.However,preliminary investigation work is a pioneering work. There are a lot of uncertainty and instability,which will encounter some unforeseen circumstances.The preliminary investigation itself was flawed and inadequate,so it must be improved and specified.%初查工作作为检察机关一项重要的立案前置环节,具有自身的特殊性,对案件能否立案起关键的决定性作用。但是,初查工作是一项探索性工作,存在诸多不确定性和不稳定性,会遇到一些难以预料的情况,其本身也存在缺陷和不足,故需对其进行相关的改进与规范。

  1. Self-assessed efficacy of a clinical musculoskeletal anatomy workshop: A preliminary survey.

    Science.gov (United States)

    Saavedra, Miguel Ángel; Navarro-Zarza, José E; Alvarez-Nemegyei, José; Canoso, Juan J; Kalish, Robert A; Villaseñor-Ovies, Pablo; Hernández-Díaz, Cristina

    2015-01-01

    To survey the efficacy of a practical workshop on clinical musculoskeletal anatomy held in five American countries. A self-assessment competence questionnaire sent to participants 1-3 months after the workshop. Results were compared to the results of a practical, instructor-assessed, pre-workshop test. The response rate of participants was 76.4%. The overall, self-assessed competence score for anatomical items that had been included in the pre-test was 76.9 (scale 0-100) as compared to an overall score of 48.1 in the practical, pre-workshop test (p<0.001). For items that were addressed in the workshop, but not included in the pre-test, self-assessed competence was rated at 62.9. Differences in anatomical knowledge between individuals from different countries and professional groups noted in the practical pre-test were no longer present in the post-test self-assessment. From this preliminary data and supporting evidence from the literature we believe that our anatomy workshop provides an effective didactic tool for increasing competence in musculoskeletal anatomy. Copyright © 2014 Elsevier España, S.L.U. All rights reserved.

  2. PVA-Sago starch hydrogel and the preliminary clinical animal study of the hydrogel

    Energy Technology Data Exchange (ETDEWEB)

    Hashim, Kamaruddin; Mohd Dahlan, Khairul Zaman [Malaysian Institute for Nuclear Technology Research, Bangi, Kajang (Malaysia); Halim, Ahmad Sukari; Md Nor, Mohd Tarmizi [Sciences University of Malaysia, School of Medical Sciences, Kerian, Kelantan (Malaysia); Yoshii, Fumio [Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment

    2002-03-01

    Sago starch granule dissolves in hot water to form physically crosslink semi-gel structure. Polyvinyl alcohol (PVA) in aqueous solution is chemically crosslink and form hydrogel after expose to gamma or electron beam irradiation. Combination of sago starch and PVA give tremendous improvement on strength and elasticity of the gel. Adding additive such as carboxymethyl cellulose enhance the swelling or absorption property of the gel. These properties of hydrogel are important for wound dressing application. The preliminary clinical animal study on the PVA Sago hydrogel dressing shows promising results of healing process in comparison with the conventional dressing using vaseline impregnated gauze acting as control dressing. This re-confirmed by biopsy tests on the wound tissue taking during the healing process. The tests show the increasing amount of fibroblast and endothelial cells on both wounds using hydrogel and jalonet during the healing process. Also, the rate of epitheliazation is almost completed for both wounds after 10 days of dressing and the lymphocytes cell increase tremendously for the first 14 days with hydrogel dressing. (author)

  3. Patient engagement: an investigation at a primary care clinic.

    Science.gov (United States)

    Gill, Preetinder Singh

    2013-01-01

    Engaged employees are an asset to any organization. They are instrumental in ensuring good commercial outcomes through continuous innovation and incremental improvement. A health care facility is similar to a regular work setting in many ways. A health care provider and a patient have roles akin to a team leader and a team member/stakeholder, respectively. Hence it can be argued that the concept of employee engagement can be applied to patients in health care settings in order to improve health outcomes. Patient engagement data were collected using a survey instrument from a primary care clinic in the northern Indian state of Punjab. Canonical correlation equations were formulated to identify combinations which were strongly related to each other. In addition, the cause-effect relationship between patient engagement and patient-perceived health outcomes was described using structural equation modeling. Canonical correlation analysis showed that the first set of canonical variables had a fairly strong relationship, ie, a magnitude > 0.80 at the 95% confidence interval, for five dimensions of patient engagement. Structural equation modeling analysis yielded a β ≥ 0.10 and a Student's t statistic ≥ 2.96 for these five dimensions. The threshold Student's t statistic was 1.99. Hence it was found the β values were significant at the 95% confidence interval for all census regions. A scaled reliable survey instrument was developed to measured patient engagement. Better patient engagement is associated with better patient-perceived health outcomes. This study provides preliminary evidence that patient engagement has a causal relationship with patient-perceived health outcomes.

  4. Patient engagement: an investigation at a primary care clinic

    Directory of Open Access Journals (Sweden)

    Gill PS

    2013-03-01

    Full Text Available Preetinder Singh Gill College of Technology, Eastern Michigan University, Ypsilanti, MI, USA Background: Engaged employees are an asset to any organization. They are instrumental in ensuring good commercial outcomes through continuous innovation and incremental improvement. A health care facility is similar to a regular work setting in many ways. A health care provider and a patient have roles akin to a team leader and a team member/stakeholder, respectively. Hence it can be argued that the concept of employee engagement can be applied to patients in health care settings in order to improve health outcomes. Methods: Patient engagement data were collected using a survey instrument from a primary care clinic in the northern Indian state of Punjab. Canonical correlation equations were formulated to identify combinations which were strongly related to each other. In addition, the cause-effect relationship between patient engagement and patient-perceived health outcomes was described using structural equation modeling. Results: Canonical correlation analysis showed that the first set of canonical variables had a fairly strong relationship, ie, a magnitude > 0.80 at the 95% confidence interval, for five dimensions of patient engagement. Structural equation modeling analysis yielded a β ≥ 0.10 and a Student's t statistic ≥ 2.96 for these five dimensions. The threshold Student's t statistic was 1.99. Hence it was found the β values were significant at the 95% confidence interval for all census regions. Conclusion: A scaled reliable survey instrument was developed to measured patient engagement. Better patient engagement is associated with better patient-perceived health outcomes. This study provides preliminary evidence that patient engagement has a causal relationship with patient-perceived health outcomes. Keywords: patient engagement, health outcomes, communication, provider effectiveness, patient incentive

  5. PET/MRI: a novel hybrid imaging technique. Major clinical indications and preliminary experience in Brazil.

    Science.gov (United States)

    Vitor, Taise; Martins, Karine Minaif; Ionescu, Tudor Mihai; Cunha, Marcelo Livorsi da; Baroni, Ronaldo Hueb; Garcia, Marcio Ricardo Taveira; Wagner, Jairo; Campos, Guilherme de Carvalho; Nogueira, Solange Amorim; Guerra, Elaine Gonçalves; Amaro, Edson

    2017-01-01

    In recent years, medical imaging with hybrid techniques has widely accepted and employed in clinical routine. PET/MRI offers significant advantages, including excellent contrast and resolution and reduced ionizing radiation, as compared to well-established PET/CT. Therefore, PET/MRI is a promising modality for oncologic imaging of some regions, such as brain, head and neck, liver and pelvis. This article set out to analyze clinical conditions that could benefit from PET/MRI imaging based on our caseload. The potential of PET/MRI to become the imaging modality of choice for assessment of neurologic and oncologic conditions associated with soft tissues is highlighted. Clinical aspects of PET/MRI and its application to clinical cases are illustrated with examples extracted from the authors' preliminary experience. RESUMO Nos últimos anos, imagens médicas com tecnologias híbridas tornaram-se amplamente aceitas e utilizadas na prática clínica. O PET/RM possui vantagens importantes, incluindo excelentes contrastes e resolução, e menor radiação ionizante, em comparação ao PET/TC. Por isto, é uma modalidade promissora para exames de imagem de pacientes oncológicos, para avaliar o cérebro, cabeça e pescoço, o fígado e a pelve. O objetivo deste artigo foi analisar as situações clínicas que se beneficiariam de exames de PET/RM a partir de uma casuística. Destacamos o potencial desta técnica se tornar o método de imagem de escolha para doenças neurológicas e oncológicas que envolvam partes moles. Os aspectos clínicos de PET/RM e sua aplicação aos casos clínicos são ilustrados com exemplos da experiência inicial dos autores.

  6. Use of cross-linked carboxymethyl cellulose for soft-tissue augmentation: preliminary clinical studies

    Directory of Open Access Journals (Sweden)

    Mauro Leonardis

    2010-11-01

    Full Text Available Mauro Leonardis1, Andrea Palange2, Rodrigo FV Dornelles3, Felipe Hund41Department of Plastic Surgery, Salvator Mundi International Hospital, Roma, Italy; 2Department of Aesthetic Medicine, Fisiobios, Roma, Italy; 3Department of Plastic Surgery, Núcleo de Plástica Avançada, São Paulo, SP, Brazil; 4Department of Plastic Surgery, Consultorio de Cirurgia Plastica, Criciuma, SC, BrazilPurpose: The continual search for new products for soft-tissue augmentation has in recent years led to the introduction of long lasting alternatives to hyaluronic acids and collagen that are composed of other polymers able to improve clinical persistence over time. This is the first report in which sodium carboxymethyl cellulose (CMC has been chemically treated by the cross-linking process and thus used as a hydrogel for soft-tissue augmentation through injection with thin needles. The study evaluates, from a clinical point of view, the behavior of cross-linked carboxymethyl cellulose hydrogel used in the aesthetic field and its side effects so as to check the safety and performance of the polymer following intradermal injections.Patients and methods: This work shows the preliminary results of an ongoing clinical study conducted between 2006 and 2009, performed on 84 healthy volunteers (62 females, 22 males aged between 18 and 72 years, for the treatment of 168 nasolabial folds, 45 perioral wrinkles, and 39 lip volume.Results: Study results show an excellent correction of facial defects. Tolerance and aesthetic quality of the correction obtained indicate considerable safety features and absence of side effects. From a clinical point of view, hydrogel is gradually absorbed into the injection site without migration issues.Conclusion: Cross-linked CMC hydrogel proves to be an ideal agent for soft tissue augmentation with regard to safety and ease of application. It did not cause infection, extrusion, migration, or adverse reactions in the patients who have been

  7. Intraprostatic injection of alcohol gel for the treatment of benign prostatic hyperplasia: preliminary clinical results.

    Science.gov (United States)

    Larson, Benjamin T; Netto, Nelson; Huidobro, Christian; de Lima, Marcelo Lopez; Matheus, Wagner; Acevedo, Cristian; Larson, Thayne R

    2006-09-06

    Benign prostatic hyperplasia (BPH) is one of the most common diseases ailing older men. Office-based procedures offer the advantage of being more effective than medications, while limiting the adverse effects, cost, and recovery of surgery. This study presents preliminary data on a new procedure that utilizes intraprostatic alcohol gel injection to ablate prostatic tissue. The purpose of this study is to evaluate the feasibility of using this gel as a treatment for BPH. A total of 65 patients with lower urinary tract symptoms (LUTS) due to BPH were treated with intraprostatic injections of alcohol gel. The gel is composed of 97% denatured alcohol and a patented polymer to cause viscosity. Three different methods of injection were utilized: transrectal (TR) injections (8), transurethral (TU) injections (36), and transperineal (TP) injections guided by biplaned ultrasound (21). Each method provided easy access to the center of the prostate, where a volume of gel, approximately 20-30% of the prostatic volume, was injected. Follow-up was based on changes in peak urinary flow (Qmax), IPSS scores, quality of life scores (QoL), adverse effects, and failures. Data are available at 3 and 12 months. The procedure was well tolerated with only local or no anesthesia in the TR and TP groups; the TU group received spinal anesthesia. All groups showed statistically significant (p gel injected was 8.05 ml, representing 21.56% of the prostatic volume. Qmax increased from a baseline mean of 8.50 to 12.01 ml/s at 3 months, and to 11.29 ml/s at 12 months. IPSS scores improved from a baseline mean of 21.12 to 10.00 at 3 months, and to 11.84 at 12 months. QoL scores were only available for 55 patients. QoL scores improved from a baseline of 3.93 to 1.98 at 3 months, and to 2.18 at 12 months. No extraprostatic injury or adverse effects were reported due to treatment. This preliminary study presents significant results showing that intraprostatic injection of alcohol gel could be an

  8. Acceptance and Commitment Therapy for Depression: A Preliminary Randomized Clinical Trial for Unemployed on Long-Term Sick Leave

    Science.gov (United States)

    Folke, Fredrik; Parling, Thomas; Melin, Lennart

    2012-01-01

    This preliminary study investigated the feasibility of a brief Acceptance and Commitment Therapy (ACT) in a Swedish sample of unemployed individuals on long-term sick leave due to depression. Participants were randomized to a nonstandardized control condition (N = 16) or to the ACT condition (N = 18) consisting of 1 individual and 5 group…

  9. Acceptance and Commitment Therapy for Depression: A Preliminary Randomized Clinical Trial for Unemployed on Long-Term Sick Leave

    Science.gov (United States)

    Folke, Fredrik; Parling, Thomas; Melin, Lennart

    2012-01-01

    This preliminary study investigated the feasibility of a brief Acceptance and Commitment Therapy (ACT) in a Swedish sample of unemployed individuals on long-term sick leave due to depression. Participants were randomized to a nonstandardized control condition (N = 16) or to the ACT condition (N = 18) consisting of 1 individual and 5 group…

  10. 78 FR 13070 - Guidance for Clinical Investigators, Industry, and Food and Drug Administration Staff: Financial...

    Science.gov (United States)

    2013-02-26

    ..., Industry, and Food and Drug Administration Staff: Financial Disclosure by Clinical Investigators..., Industry, and FDA Staff: Financial Disclosure by Clinical Investigators.'' This guidance is intended to... governing financial disclosure by clinical investigators. This guidance provides FDA's responses to the...

  11. 77 FR 69632 - Draft Guidance for Industry on Electronic Source Data in Clinical Investigations; Availability

    Science.gov (United States)

    2012-11-20

    ... entitled ``Electronic Source Data in Clinical Investigations.'' This document revises and updates the draft... in FDA- regulated clinical investigations. The revised draft guidance promotes capturing source data... draft guidance for industry entitled ``Electronic Source Data in Clinical Investigations.''...

  12. 78 FR 57395 - Guidance for Industry on Electronic Source Data in Clinical Investigations; Availability

    Science.gov (United States)

    2013-09-18

    ... ``Electronic Source Data in Clinical Investigations.'' This document provides guidance to sponsors, contract... retention of electronic source data in FDA-regulated clinical investigations. This guidance promotes... a guidance for industry entitled ``Electronic Source Data in Clinical Investigations.''...

  13. The use and effectiveness of the eLib subject gateways: a preliminary investigation

    OpenAIRE

    Mackie, M; Burton, P.F.

    1999-01-01

    Internet subject gateways were set up under the Electronic Libraries Programme (eLib) in order to address some of the problems of searching the Internet which have been identified by information professionals, i.e. locating relevant, good quality information. This preliminary study examines the extent to which academics in two universities use three eLib subject gateways (EEVL, OMNI and SOSIG). The results are generally encouraging for the eLib programme, but it is necessary for the gateways ...

  14. A new extra-abdominal channel alternative to the mitrofanoff principle: experimental and preliminary clinical experience

    Directory of Open Access Journals (Sweden)

    Antonio Macedo Jr.

    2009-04-01

    Full Text Available INTRODUCTION: The appendix is the gold-standard channel for the Mitrofanoff principle in pediatric urology, but the search for alternatives is justified considering it may not be available or preferably used for colonic stomas (Malone antegrade continence enema. The aim of this study is to report on technical feasibility of a new approach for creating catheterizable channels in a rabbit model and to present our preliminary clinical experience. MATERIAL AND METHODS: We configured a tube from two rectangular skin flaps 1x4 cm opposite each other in the middle line of the lower inferior abdomen. The channel was anastomosed to the bladder dome with embedding sutures to create a valvular mechanism. The experimental study consisted of 12 rabbits, divided in 4 groups according to the sacrifice schedule at 2, 4, 8 and 12 weeks. At 30th postoperative day, an urodynamic evaluation was performed to record continence of the stoma. A histological analysis of the specimens stained with hematoxylin-eosin, Masson trichrome and Picrosirius red was also done in group 2 (sacrifice at 4 weeks postoperatively. We used this method in 3 patients with congenital non-neurogenic bladder disease presenting with massive residual volumes without compliance deficits. RESULT: The technique proved feasible in all animals, 9 of 12 could be easily catheterized and underwent urodynamic study. No stoma leakage was observed in 7 animals at high bladder pressures (> 50 cm H20 and only 2 animals had some leakage at 40 cm H20. Urodynamics performed through the stoma showed urethral leakage at 20 cm H20, therefore demonstrating the efficacy of the valvular mechanism. Histological analysis confirmed good integration between the tube and the bladder. Mean follow-up of the clinical series (3 patients was 7.2 months. Two patients remained continent up to 4 hours, whereas 1 patient had some leakage after 2 hours. CONCLUSION: We were able to confirm feasibility of a new extra

  15. Curvature affects Doppler investigation of vessels: implications for clinical practice.

    Science.gov (United States)

    Balbis, S; Roatta, S; Guiot, C

    2005-01-01

    In clinical practice, blood velocity estimations from Doppler examination of curved vascular segments are normally different from those of nearby straight segments. The observed "accelerations," sometimes considered as a sort of stochastic disturbances, can actually be related to very specific physical effects due to vessel curvature (i.e., the development of nonaxial velocity [NAV] components) and the spreading of the axial velocity direction in the Doppler sample volume with respect to the insonation axis. The relevant phenomena and their dependence on the radius of curvature of the vessels and on the insonation angle are investigated with a beam-vessel geometry as close as possible to clinical setting, with the simplifying assumptions of steady flow, mild vessel curvature, uniform ultrasonic beam and complete vessel insonation. The insonation angles that minimize the errors are provided on the basis of the study results.

  16. 76 FR 32367 - Draft Guidance for Clinical Investigators, Industry, and FDA Staff: Financial Disclosure by...

    Science.gov (United States)

    2011-06-06

    ... Staff: Financial Disclosure by Clinical Investigators; Correction AGENCY: Food and Drug Administration...: Financial Disclosure by Clinical Investigators.''The document was published with an incorrect docket...

  17. Experimental oral toxicity of domoic acid in cynomolgus monkeys (Macaca fascicularis) and rats. Preliminary investigations.

    Science.gov (United States)

    Tryphonas, L; Truelove, J; Todd, E; Nera, E; Iverson, F

    1990-10-01

    A recent outbreak of marine food poisoning in humans was attributed to the consumption of blue mussels (Mytilus edulis L.) contaminated with domoic acid (DA) that was produced by the diatom Nitzschia pungens. The clinical and morphological effects of single oral doses of extracts of mussels contaminated with DA or of DA isolated from toxic mussels were investigated in small groups (one to six) of cynomolgus monkeys (Macaca fascicularis; 0.5-10 mg DA/kg body weight) and of Sprague-Dawley rats (60 to 80 mg DA/kg body weight). Control animals were either given saline or were not treated. To test whether monosodium glutamate, present in the food consumed by some affected humans, and dimethylsulphoxide, suspected of being present in the plankton, enhanced the response, monosodium glutamate (at 0.25% of mussel extract bolus) or dimethylsulphoxide (at 1 g per bolus) were co-administered to two (one each) of the DA-treated monkeys. DA-treated monkeys developed transient excitation characterized by vomiting. DA-treated rats showed withdrawal followed by hyperexcitation and death (in one case). Mild to moderate central nervous system lesions consistent with neuroexcitation were present in both monkeys and rats. The addition of monosodium glutamate and dimethylsulphoxide had no significant effect on the appearance and severity of central nervous system clinical signs and lesions. The wide variations in the response of test animals to orally administered DA were attributed to the protective effect of vomiting, and to suspected incomplete or slow gastro-intestinal absorption of the toxic agent. The results reinforce the view that DA is an emetic and that under appropriate conditions may also inflict excitotoxic central nervous system damage.

  18. Sodium alginate as an ideal submucosal injection material for endoscopic submucosal resection: preliminary experimental and clinical study.

    Science.gov (United States)

    Akagi, Tomonori; Yasuda, Kazuhiro; Tajima, Masaaki; Suzuki, Kosuke; Inomata, Masafumi; Shiraishi, Norio; Sato, Yuhki; Kitano, Seigo

    2011-11-01

    Sodium alginate is used clinically in the treatment of peptic ulcer disease. Because of its viscosity, sodium alginate could possibly become a new submucosal injection material for use in endoscopic resection. We evaluated the feasibility of endoscopic submucosal dissection (ESD) using sodium alginate. The lesion-lifting properties of sodium alginate were examined in porcine stomachs and were compared with those of normal saline solution and sodium hyaluronate solution. After confirming the proper concentration of sodium alginate, ESD using sodium alginate was performed in 11 patients with gastric mucosal cancer or adenoma. The lesion-lifting properties of sodium alginate and clinical outcomes were assessed. The thickness of the submucosal elevation created by 3% sodium alginate in porcine stomach was equivalent to that of sodium hyaluronate. ESD using sodium alginate was completed successfully in all patients without adverse effects except in 1 patient in whom transient shrinkage of the gastric wall disappeared spontaneously after approximately 30 minutes. The mean tumor size was 15.3 mm. En bloc resection and a negative resection margin were obtained in all. Histopathologic examination revealed that all tumors were confined to the mucosal layer except for 1 that was confined to the submucosal layer without lymphovascular invasion, and there were no adverse effects such as tissue damage. No patient required additional treatment, and none showed recurrence during a median follow-up period of 28 months. Small sample size. This preliminary study suggests that sodium alginate might be a novel, safe submucosal injection material for use in endoscopic resection. Further investigation of the properties of sodium alginate is warranted. Copyright © 2011 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.

  19. Clinical Preliminary Study on Biodegradable Subcuta neous Contraceptive Implant-CaproF

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    CaproF is a biodegradable subcutaneous contraceptive implant of releasing lev onorgestrel (LNG), which is expected to provide an effective contraception for 2 years. This study was undertaken to assess the one-year preliminary clinical results of using CaproF in 19 subjects. All subjects (n = 19) completed the 1-year study, and the contraceptive effectiveness and follow up rate were both 100%. The incidence of side effects was low. The major side effects were menstrual disorder, but bleeding patterns tended to be improved and restored to be the same as pre-implantation ones with time. There were no significant increase in weight (P> 0. 05) and no changes in blood pres sure. In the 3d, 6th and 12th months after using CaproF, the cervical mucus became scanty and viscous without fern-like crystals. The amount of menstrual blood loss de creased from 49. 38 ml of pre-implantation to 33. 23 ml of the 12th month of using the implant (P<0.05). Hemoglobin concentrations showed no changes, but serum ferritin concentrations were slightly increased. No changes in liver function, kidney function, glucose tolerance test and lipoprotein levels were found. Determinations of sex hor mones (FSH, LH, E2 and progesterone) levels, ultrasonography of ovary, and en dometrial biopsy in observed group (n = 9) showed that all had normal ovulation before insertion. But ovulation was suppressed and endometrium development was inhibited after insertion. All basal body temperatures were single-phase patterns during the 1- year follow-up. This study suggested that CaproF is an effective, safe and acceptable long-acting contraceptive method. It is likely to reach its contraceptive effectiveness through suppressing ovulation, inhibiting endometrium development and influencing cervical musus characteristics.

  20. Clinical Preliminary Study on Biodegradable Subcuta-neous Contraceptive Implant-CaproF

    Institute of Scientific and Technical Information of China (English)

    刘春海; 钱丽娟

    2000-01-01

    CaproF is a biodegradable subcutaneous contraceptive implant of releasing lev-onorgestrel (LNG), which is expected to provide an effective contraception for 2 years. This study was undertaken to assess the one-year preliminary clinical results of using CaproF in 19 subjects. All subjects (n = 19) completed the 1-year study, and the contraceptive effectiveness and follow up rate were both 100%. The incidence of side effects was low. The major side effects were menstrual disorder, but bleeding patterns tended to be improved and restored to be the same as pre-implantation ones with time.There were no significant increase in weight (P> 0. 05) and no changes in blood pres-sure. In the 3rd, 6th and 12th months after using CaproF, the cervical mucus became scanty and viscous without fern-like crystals. The amount of menstrual blood loss de-creased from 49. 38 ml of pre-implantation to 33. 23 ml of the 12th month of using the implant (P< 0. 05). Hemoglobin concentrations showed no changes, but serum ferritin concentrations were slightly increased. No changes in liver function, kidney function,glucose tolerance test and lipoprotein levels zoere found. Determinations of sex hor-mones (FSH , LH , E2 and progesterone) levels, ultrasonography of ovary, and en-dometrial biopsy in observed group (n = 9) shorted that all had normal ovulation before insertion. But ovulation was suppressed and endometrium development was inhibited after insertion. All basal body temperatures were single-phase patterns during the 1-year follow-up. This study suggested that CaproF is an effective, safe and acceptable long-acting contraceptive method. It is likely to reach its contraceptive effectiveness through suppressing ovulation, inhibiting endometrium development and influencing cervical mucus characteristics.

  1. Predicting diagnostic error in radiology via eye-tracking and image analytics: Preliminary investigation in mammography

    Energy Technology Data Exchange (ETDEWEB)

    Voisin, Sophie; Tourassi, Georgia D. [Biomedical Science and Engineering Center, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831 (United States); Pinto, Frank [School of Engineering, Science, and Technology, Virginia State University, Petersburg, Virginia 23806 (United States); Morin-Ducote, Garnetta; Hudson, Kathleen B. [Department of Radiology, University of Tennessee Medical Center at Knoxville, Knoxville, Tennessee 37920 (United States)

    2013-10-15

    Purpose: The primary aim of the present study was to test the feasibility of predicting diagnostic errors in mammography by merging radiologists’ gaze behavior and image characteristics. A secondary aim was to investigate group-based and personalized predictive models for radiologists of variable experience levels.Methods: The study was performed for the clinical task of assessing the likelihood of malignancy of mammographic masses. Eye-tracking data and diagnostic decisions for 40 cases were acquired from four Radiology residents and two breast imaging experts as part of an IRB-approved pilot study. Gaze behavior features were extracted from the eye-tracking data. Computer-generated and BIRADS images features were extracted from the images. Finally, machine learning algorithms were used to merge gaze and image features for predicting human error. Feature selection was thoroughly explored to determine the relative contribution of the various features. Group-based and personalized user modeling was also investigated.Results: Machine learning can be used to predict diagnostic error by merging gaze behavior characteristics from the radiologist and textural characteristics from the image under review. Leveraging data collected from multiple readers produced a reasonable group model [area under the ROC curve (AUC) = 0.792 ± 0.030]. Personalized user modeling was far more accurate for the more experienced readers (AUC = 0.837 ± 0.029) than for the less experienced ones (AUC = 0.667 ± 0.099). The best performing group-based and personalized predictive models involved combinations of both gaze and image features.Conclusions: Diagnostic errors in mammography can be predicted to a good extent by leveraging the radiologists’ gaze behavior and image content.

  2. A preliminary mixed-method investigation of trust and hidden signals in medical consultations.

    Directory of Open Access Journals (Sweden)

    Silvia Riva

    Full Text Available BACKGROUND: Several factors influence patients' trust, and trust influences the doctor-patient relationship. Recent literature has investigated the quality of the personal relationship and its dynamics by considering the role of communication and the elements that influence trust giving in the frame of general practitioner (GP consultations. OBJECTIVE: We analysed certain aspects of the interaction between patients and GPs to understand trust formation and maintenance by focusing on communication channels. The impact of socio-demographic variables in trust relationships was also evaluated. METHOD: A cross-sectional design using concurrent mixed qualitative and quantitative research methods was employed. One hundred adults were involved in a semi-structured interview composed of both qualitative and quantitative items for descriptive and exploratory purposes. The study was conducted in six community-based departments adjacent to primary care clinics in Trento, Italy. RESULTS: The findings revealed that patients trusted their GP to a high extent by relying on simple signals that were based on the quality of the one-to-one communication and on behavioural and relational patterns. Patients inferred the ability of their GP by adopting simple heuristics based mainly on the so-called social "honest signals" rather than on content-dependent features. Furthermore, socio-demographic variables affected trust: less literate and elderly people tended to trust more. CONCLUSIONS: This study is unique in attempting to explore the role of simple signals in trust relationships within medical consultation: people shape trust and give meaning to their relationships through a powerful channel of communication that orbits not around words but around social relations. The findings have implications for both clinicians and researchers. For doctors, these results suggest a way of thinking about encounters with patients. For researchers, the findings underline the

  3. PHYSICO-CHEMICAL AND PRELIMINARY PHYTOCHEMICAL INVESTIGATION OF THUJA OCCIDENTALIS LINN. (CUPRESSACEAE DRIED LEAVES

    Directory of Open Access Journals (Sweden)

    Bhan Meenu

    2011-03-01

    Full Text Available Thuja occidentalis is a monoecious coniferous plant having a wide variety of medicinal value. It has hepatoprotective, anti-oxidant, anti-bacterial, anti-fungal, anti-cancer, anti-diabetic activity etc. In the present paper, T. occidentalis leaves has been standardized on the basis of organoleptic, physical and physico-chemical characteristics. Methanolic and hydro-alcoholic extracts have been prepared by microwave assisted extraction technique and subjected to preliminary phytochemical screening and thin layer chromatography (TLC. TLC fingerprinting profile has been obtained using different solvent systems.

  4. Preliminary Results on the Experimental Investigation of the Structure Functions of Bound Nucleons

    Energy Technology Data Exchange (ETDEWEB)

    Bodek, Arie [Univ. of Rochester, NY (United States); Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

    2016-08-01

    We present preliminary results on an experimental study of the nuclear modification of the longitudinal ($\\sigma_L$) and transverse ($\\sigma_T$) structure functions of nucleons bound in nuclear targets. The origin of these modifications (commonly referred as as the EMC effect) is not fully understood. Our measurements of R= $\\sigma_L / \\sigma_T$ for nuclei ($R_A$) and for deuterium ($R_D$) indicate that nuclear modifications of the structure functions of bound nucleons are different for the longitudinal and transverse structure functions, and that contrary to expectation from several theoretical models, $R_A< R_D$.

  5. Preliminary investigations on fossil diversity variation of Mesozoic Marattialean ferns in China

    Institute of Scientific and Technical Information of China (English)

    Zikun JIANG; Yongdong WANG; and Ning TIAN

    2008-01-01

    The Marattiales is one of the oldest lineages of vascular plants with extensive fossil records dated back to the Carboniferous. Understanding the fossil diversity variation and distribution pattern is helpful for exploring the evolutionary history of this fern group. In this work, the preliminary analysis of diversity change and distribution of the Mesozoic Marattialean fossil records in China are reported covering the Triassic and Jurassic periods based on available published data. In addition, a brief discussion is made regarding to the potential causes for these variation and distribution of this fern group.

  6. Preliminary Results on the Experimental Investigation of the Structure Functions of Bound Nucleons

    CERN Document Server

    Bodek, A

    2015-01-01

    We present preliminary results on an experimental study of the nuclear modification of the longitudinal ($\\sigma_L$) and transverse ($\\sigma_T$) structure functions of nucleons bound in nuclear targets. The origin of these modifications (commonly referred as as the EMC effect) is not fully understood. Our measurements of R= $\\sigma_L / \\sigma_T$ for nuclei ($R_A$) and for deuterium ($R_D$) indicate that nuclear modifications of the structure functions of bound nucleons are different for the longitudinal and transverse structure functions, and that contrary to expectation from several theoretical models, $R_A< R_D$.

  7. Preliminary clinical outcomes of percutaneous kyphoplasty with Sky-bone expander

    Institute of Scientific and Technical Information of China (English)

    ZHENG Zhao-min; KUANG Guan-ming; DONG Zhi-yong; K.M.C. Cheung; William W. Lu; LI Fo-bao

    2007-01-01

    Background Percutaneous kyphoplasty (PKP) using balloon expander has been proved to be effective in the treatment of painful vertebral compression fractures. Recently, Sky-bone expander, an alternative bone expander for PKP has been developed. The purpose of this study was to show our preliminary clinical outcomes of PKP with Sky-bone expander.Methods PKP with Sky-bone expander was performed in 25 patients (30 vertebrae). The operation time, bleeding volume, cement volume injected were recorded. The pain and functional activities of the patients before and after the operation were compared using Wilcoxon signed-rank test. The cement distribution in the vertebrae, vertebral height restoration, and kyphosis correction after the procedure were evaluated by radiography. The pre- and post-operative absolute values of the vertebral height and kyphotic angle were compared by paired-sample t test. All the patients were followed up by telephone or clinic consulting after being discharged from our hospital.Results The procedure was performed successfully in all the patients. Bipedicular injection was used in 2 of the patients, and unipedicular injection was made in the others. The operation time ranged from 25 to 120 minutes (45 minutes per vertebra on average). The average bleeding volume was about 20 ml. Polymethylmethacrylate1.5 - 5.0 ml (mean, (3.15±0.78) ml) was injected through each pedicle into all the patients except one, who received calcium sulphate 3.5 ml instead. The patients were followed up for 12-15 months (13.5 months on average). The mean visual analogue scale (VAS) score, Oswestry Disability Index, anterior, midline, and posterior vertebral height, and kyphotic angle of the patients were improved significantly at the end of the follow-up compared with those before the operation.(2.5±1.3, 35.1%, (20.94±6.15) mm, (20.26±4.59) mm, (26.72±3.49) mm, and 8.2 degrees vs. 8.5±1.9, 61.2%, (19.11±6.72) mm, (15.88±5.73) mm, (25.78±3.67) mm, and 17.3 degrees

  8. Family Histories of Anxiety in Overweight Men and Women with Binge Eating Disorder: A Preliminary Investigation

    Science.gov (United States)

    Blomquist, Kerstin K.; Grilo, Carlos M.

    2015-01-01

    Objective A preliminary examination of the significance of family histories of anxiety in the expression of binge eating disorder (BED) and associated functioning. Methods Participants were 166 overweight patients with BED assessed using diagnostic interviews. Participants were administered a structured psychiatric history interview about their first-degree relatives (parents, siblings, children) (N=897) to determine lifetime diagnoses of DSM-IV anxiety disorders and completed a battery of questionnaires assessing current and historical eating and weight variables and associated psychological functioning (depression). Results BED patients with a family history of anxiety disorder were significantly more likely than BED patients without a family history of anxiety disorder to have lifetime diagnoses of anxiety disorders and mood disorders but not substance use disorders. A family history of anxiety was not significantly associated with timing or sequencing of age at onset of anxiety disorder, binge eating, dieting, or obesity, or with variability in current levels of binge eating, eating disorder psychopathology, or psychological functioning. Conclusions Although replication with direct interview method is needed, our preliminary findings suggest that a family history of anxiety confers greater risk for comorbid anxiety and mood disorders but is largely unrelated to the development of binge eating, dieting, or obesity and unrelated to variability in eating disorder psychopathology or psychological functioning in overweight patients with BED. PMID:26343481

  9. Preliminary evaluation of a new clinical algorithm to interpret blood cultures growing coagulase-negative staphylococci.

    Science.gov (United States)

    Schnell, David; Lécuyer, Hervé; Geeraerts, Thomas; Dumenil, Anne-Sylvie; Bille, Emmanuelle; Mercier, Frédéric J; Benhamou, Dan; Zahar, Jean-Ralph

    2013-07-01

    Evaluating the clinical significance of blood cultures positive for coagulase-negative staphylococci (CoNS) is of critical importance since these microorganisms represent both the first contaminants of blood cultures and one of the leading causes of bloodstream infection (BSI). This prospective 2-centre study aimed to compare a previously reported algorithm to a clinical algorithm based on our experience. We identified 84 patients with CoNS-positive blood cultures. Twenty-seven (32%) were considered to have BSI according to our study algorithm. Thirty-seven (44%) patients were considered to have CoNS BSI according to the previously reported algorithm. The 2 algorithms isolated patients with similar rates of recurrences and hospital mortality. Our algorithm seemed to result in less diagnoses of CoNS BSI without harmful consequences compared to the previously reported algorithm. The impact on patient outcome and the inappropriate use of antibiotics deserves further investigation.

  10. Ossiculoplasty in Missing Malleus and Stapes Patients : Experimental and Preliminary Clinical Results With a New Malleus Replacement Prosthesis With the Otology-Neurotology Database

    NARCIS (Netherlands)

    Vincent, Robert; Bittermann, Arnold J. N.; Wenzel, Gentiana; Oates, John; Sperling, Neil; Lenarz, Thomas; Grolman, Wilko

    2013-01-01

    Objective: To present the preliminary results of new malleus replacement prosthesis combined with a total ossicular prosthesis in middle ear reconstruction in patients missing the malleus and stapes. Study Design: Prospective experimental and nonrandomized clinical study. Setting: Tertiary referral

  11. Preliminary investigations into the bioconversion of gamma irradiated agricultural waste by Pleurotus spp.

    Science.gov (United States)

    Gbedemah, C. M.; Obodai, M.; Sawyerr, L. C.

    1998-06-01

    The application of gamma irradiation for pretreatment of lignocellulosic materials for their hydrolysis and to increase their digestibility for rumen animal have been reported in the literature. Gamma irradiation of corn stover in combination with sodium hydroxide for bioconversion of polysaccharide into protein by Pleurotus spp has also been reported. In this study experiments were designed to find out whether gamma radiation could serve both as a decontaminating agent as well as hydrolytic agent of sawdust for the bioconversion of four varieties of Pleurotus spp. Preliminary results indicate that a dose of 20kGy of gamma irradiation increase the yield of Pleurotus eous var ET-8 whilst decreasing the yield of other varieties.

  12. Investigation of the tetraquark candidate $a_0(980)$: technical aspects and preliminary results

    CERN Document Server

    Abdel-Rehim, Abdou; Berlin, Joshua; Brida, Mattia Dalla; Gravina, Mario; Wagner, Marc

    2014-01-01

    We discuss technical aspects and first results of a lattice QCD study of the $a_0(980)$ state. We employ various interpolating operators of quark-antiquark, mesonic molecule, diquark-antidiquark and two-meson type. Both connected and disconnected contributions including diagrams with closed fermion loops are computed. To keep statistical errors small, it is essential to optimize the computation of these diagrams by choosing that combination of techniques most appropriate for each type of diagram from the correlation matrix of interpolating operators. We illustrate, how this can be done, by discussing certain diagrams in detail. We also present preliminary results corresponding to a $4\\times 4$ submatrix computed with 2+1 flavors of clover fermions.

  13. Preliminary investigation of the advertising and availability of PREPs, the new "safe" tobacco products.

    Science.gov (United States)

    Hickman, Norval; Klonoff, Elizabeth A; Landrine, Hope; Kashima, Kennon; Parekh, Bina; Fernandez, Senaida; Thomas, Kamala; Brouillard, Catherine; Zolezzi, Michele; Jensen, Jennifer; Weslowski, Zorahna

    2004-08-01

    The tobacco industry recently introduced a new set of "safe" cigarettes and nicotine delivery devices that purportedly entail reduced tobacco-related disease risk due to their lower level of some carcinogens and toxins. Little is know about the biological impact of these potential reduced exposure products (PREPs) and nothing is known about their advertising and availability. Hence, two pilot studies were conducted to examine the latter issues for the first time. In Study 1, we examined tobacco ads in 10 popular magazines 1998--2002 and found that only 1% of ads were for PREPs. In Study 2, we attempted to purchase PREPs in a random sample of 113 small stores and found that only 4.4% sold any PREP. These preliminary findings tentatively suggest that the industry might not yet be heavily invested in products that have the potential to increase tobacco use by decreasing its perceived harm. Studies with larger samples are recommended.

  14. Parallel Strands A Preliminary Investigation into Mining the Web for Bilingual Text

    CERN Document Server

    Resnik, P

    1998-01-01

    Parallel corpora are a valuable resource for machine translation, but at present their availability and utility is limited by genre- and domain-specificity, licensing restrictions, and the basic difficulty of locating parallel texts in all but the most dominant of the world's languages. A parallel corpus resource not yet explored is the World Wide Web, which hosts an abundance of pages in parallel translation, offering a potential solution to some of these problems and unique opportunities of its own. This paper presents the necessary first step in that exploration: a method for automatically finding parallel translated documents on the Web. The technique is conceptually simple, fully language independent, and scalable, and preliminary evaluation results indicate that the method may be accurate enough to apply without human intervention.

  15. Preliminary Results on the Experimental Investigation of the Structure Functions of Bound Nucleons

    Energy Technology Data Exchange (ETDEWEB)

    Bodek, Arie [University of Rochester, Rochester, NY

    2015-09-01

    We present preliminary results on an experimental study of the nuclear modification of the longitudinal (σL) and transverse (σT) structure functions of nucleons bound in nuclear targets. The origin of these modifications (commonly referred as as the EMC effect) is not fully understood. Our measurements of R= σLT for nuclei (RA) and for deuterium (RD) indicate that nuclear modifications of the structure functions of bound nucleons are different for the longitudinal and transverse structure functions, and that contrary to expectation from several theoretical models, RA < RD.

  16. Preliminary Clinical Observation on Treatment of Chronic Rhinitis with Rhinitis Spray

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Objective: To investigate the clinical effect of Rhinitis Spray (RS) in treating chronic rhinitis. Methods: Eighty patients with chronic rhinitis were divided into three groups, and treated with RS, ephedrine and normal saline respectively. Results: The short-term effective rate in the three groups was 89.3%, 66.7% and 8.0% respectively. RS was effective in alleviating symptoms, increasing IgG level in nasal discharge, improving ventilation of nasal cavity and transfer function of cilia of nasal mucosa obviously. Conclusion: The therapeutic effect of RS in treating chronic rhinitis is good.

  17. Preliminary Clinical Observation on Treatment of Chronic Simple and Hypertrophic Rhinitis with Rhinitis Spray

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Objective: To investigate the clinical effect of Rhinitis Spray (RS) in treating chronic simple and hypertrophic rhinitis. Methods: Eighty patients with chronic rhinitis were divided into three groups and treated with RS, ephedrine and normal saline respectively. Results: The short-term effective rate in the three groups was 89.3%, 66.7% and 8.0% respectively. RS was effective in alleviating symptoms, increasing IgG level in nasal discharge, improving ventilatory function of nasal cavity and transfer function of nasal muosa cilia obviously. Conclusion: The therapeutic effect of RS in treating chronic rhinitis is satisfactory.

  18. Investigating feedback mechanisms between stress and grain-size: preliminary findings from finite-element modelling

    Science.gov (United States)

    Cross, A. J.; Prior, D. J.; Ellis, S. M.

    2012-12-01

    It is widely accepted that changes in stress and grain size can induce a switch between grain-size insensitive (GSI) and sensitive (GSS) creep mechanisms. Under steady-state conditions, grains evolve to an equilibrium size in the boundary region between GSS and GSI, described by the paleopiezometer for a given material. Under these conditions, significant rheological weakening is not expected, as grain size reduction processes are balanced by grain growth processes. However, it has been shown that the stress field surrounding faults varies through the seismic cycle, with both rapid loading and unloading of stress possible in the co- and post-seismic stages. We propose that these changes in stress in the region of the brittle-ductile transition zone may be sufficient to force a deviation from the GSI-GSS boundary and thereby cause a change in grain size and creep mechanism prior to system re-equilibration. Here we present preliminary findings from numerical modelling of stress and grain size changes in response to loading of mechanical inhomogeneities. Our results are attained using a grain-size evolution (GSE) subroutine incorporated into the SULEC finite-element code developed by Susan Ellis and Susanne Buiter, which utilises an iterative approach of solving for spatial and temporal changes in differential stress, grain size and active creep mechanism. Preliminary models demonstrate that stress changes in response to the opening of a fracture in a flowing medium can be significant enough to cause a switch from GSI to GSS creep. These results are significant in the context of understanding spatial variations and feedback between stress, grain size and deformation mechanisms through the seismic cycle.

  19. Low-level arsenic exposure via drinking water consumption and female fecundity - A preliminary investigation.

    Science.gov (United States)

    Susko, Michele L; Bloom, Michael S; Neamtiu, Iulia A; Appleton, Allison A; Surdu, Simona; Pop, Cristian; Fitzgerald, Edward F; Anastasiu, Doru; Gurzau, Eugen S

    2017-04-01

    High level arsenic exposure is associated with reproductive toxicity in experimental and observational studies; however, few data exist to assess risks at low levels. Even less data are available to evaluate the impact of low level arsenic exposure on human fecundity. Our aim in this pilot study was a preliminary evaluation of associations between low level drinking water arsenic contamination and female fecundity. This retrospective study was conducted among women previously recruited to a hospital-based case-control study of spontaneous pregnancy loss in Timiṣ County, Romania. Women (n=94) with planned pregnancies of 5-20 weeks gestation completed a comprehensive physician-administered study questionnaire and reported the number of menstrual cycles attempting to conceive as the time to pregnancy (TTP). Drinking water samples were collected from residential drinking water sources and we determined arsenic levels using hydride generation-atomic absorption spectrometry (HG-AAS). Multivariable Cox-proportional hazards regression with Efron approximation was employed to evaluate TTP as a function of drinking water arsenic concentrations among planned pregnancies, adjusted for covariates. There was no main effect for drinking water arsenic exposure, yet the conditional probability for pregnancy was modestly lower among arsenic exposed women with longer TTPs, relative to women with shorter TTPs, and relative to unexposed women. For example, 1µg/L average drinking water arsenic conferred 5%, 8%, and 10% lower likelihoods for pregnancy in the 6th, 9th, and 12th cycles, respectively (P=0.01). While preliminary, our results suggest that low level arsenic contamination in residential drinking water sources may further impair fecundity among women with longer waiting times; however, this hypothesis requires confirmation by a future, more definitive study. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. 非影像依赖型计算机辅助全膝关节置换术的初步临床观察%Investigation of preliminary clinical outcome following total knee arthroplasty using image-free computer-assisted navigation system

    Institute of Scientific and Technical Information of China (English)

    李晓辉; 于建华; 郑得志; 贾健; 龚跃昆; 卜延民; 赵秀祥

    2009-01-01

    Objective To investigate the technique, learning curve, and early clinical effects of computer-assisted total knee arthroplasty (TKA) or standard instrumentation TKA. Methods From August2007 to May 2008, 60 KSS-A type patients (67 knees) underwent primary TKA operations by the same surgi-cal team. Among them, 22 knees underwent THA with the aid of the image-free navigation system (including5 knees and 17 knees, with the average age of 64.53 years); the other 45 underwent conventional TKA (12 knees and 33 knees, with the average age of 66.34 years). The preoperative demographic data and functional data have no statistical differences. The operation time, blood loss, duration of early postoperative quadriceps dysfunctions and complications were compared between the two groups. Results The operating time was significantly longer in computer-assisted group compared with conventional TKA group (P0.05). No patient who received computer-assisted TKA had an extent lag of more than 25 degrees 5 days postoperatively. Conclusion Use of image-free navigation system in TKA has improved the accuracy of total knee prosthesis alignment, and provided faster quadriceps functional re-covery than conventional manual methods. The technique of using of Image-free navigation system in TKA is easy to use, and has a short learning curve.%目的 探讨非影像依赖型计算机辅助全膝关节置换术的技术特点、学习曲线及早期临床疗效.方法 2007年8月至2008年5月应用非影像依赖型无线导航技术(导航组)辅助人工全膝关节置换术治疗KSS.A类患者19例22膝,男5例5膝,女14例17膝,平均年龄64.53岁;同期应用器械定位技术(非导航组)41例45膝,男11例12膝,女30例33膝,平均年龄66.34岁.两组患者术前一般资料、下肢力线和关节活动度无差异.比较两组手术时间、出血量、术后力线内或外翻偏差、早期关节最大屈曲角度及股四头肌功能恢复情况.结果 导航组手术时间比非

  1. [Air conducted ocular VEMP: II. First clinical investigations].

    Science.gov (United States)

    Walther, L E; Schaaf, H; Sommer, D; Hörmann, K

    2011-10-01

    Vestibular-evoked myogenic potentials (VEMP) are widely used to assess vestibular function. Air conducted (AC) cervical VEMP (cVEMP) reflect sacculus and inferior vestibular nerve function. Ocular VEMP (oVEMP) however has been hardly examined up to now. In recent studies it has been assumed that AC oVEMP probably reflects superior vestibular nerve function. The aim of this pilot study was to evaluate clinical application of the AC oVEMP. AC oVEMP were recorded in patients with peripheral vestibular disorders (n=21). In addition thermal irritation and head impulse test were performed and AC cVEMP were recorded. For intense AC-sound stimulation tone bursts (500 Hz) with 100 dB nHL were used. In peripheral vestibular disorders AC oVEMP and AC cVEMP could be classified into: • type 1 (inferior vestibular neuritis) with loss of AC oVEMP but normal AC cVEMP, • type 2, probable type of superior vestibular neuritis, showing present AC cVEMP but loss of AC oVEMP, • type 3, probable complete vestibular neuritis, without AC oVEMP and AC cVEMP. AC oVEMP may be used as an appropriate test for clinical investigation in patients with vestibular disorders. AC oVEMP is an additional, essential test for assessing otolith function beside AC cVEMP. Further vestibular test are necessary for precise clinical interpretation. © Georg Thieme Verlag KG Stuttgart · New York.

  2. Editorial: Process to progress? Investigative trials, mechanism and clinical science.

    Science.gov (United States)

    Green, Jonathan

    2015-01-01

    In 2002 Helena Kraemer and colleagues published an important article on the analysis of clinical trials in mental health, which advocated a planned focus on mechanisms to investigate the processes behind treatment effects. Kraemer et al. considered not only new approaches to mediation analysis, but also a theoretical approach to factors, both pre-treatment and during treatment, that might moderate this mediation. Trials should not just be about whether a treatment 'worked', but how it worked; with the results informing modification of the intervention for the next trial by discarding aspects that were not effective and reinforcing aspects that were - an iterative procedure towards greater effectiveness. Can we enjoy similar ambitions for complex interventions within mental health? It is not so long ago when the received wisdom within the clinical and much of the research community was that it was simply impossible in practice to mount randomised controlled trials relevant to the kind of psychosocial interventions we use in child and adolescent mental health (CAMHS). How different the situation is now, with burgeoning interest in a systematic evidence base for psychological treatment and the possibilities for unexpected advances (as well as unexpected harms). Nevertheless it is probably still fair to say that the systematic use of process and mechanism study within trials in our field is the exception rather than the rule. What are the possibilities and implications for our field?

  3. Clinical features of Crohn disease concomitant with ankylosing spondylitis: A preliminary single-center study.

    Science.gov (United States)

    Liu, Song; Ding, Jie; Wang, Meng; Zhou, Wanqing; Feng, Min; Guan, Wenxian

    2016-07-01

    Extraintestinal manifestations (EIMs) cause increased morbidity and decreased quality of life in Crohn disease (CD). Ankylosing spondylitis (AS) belongs to EIMs. Very little is known on the clinical features of CD concomitant with AS. This study is to investigate the clinical features of CD patients with AS.We retrospectively collected all CD patients with AS in our hospital, and established a comparison group (CD without AS) with age, sex, and duration of Crohn disease matched. Clinical information was retrieved for comparison.Eight CD + AS patients were identified from 195 CD patients. Sixteen CD patients were randomly selected into comparison group. All CD + AS patients were male, HLA-B27 (+), and rheumatoid factor (-) with an average age of 40.8 ± 4.52 years. Significant correlation between disease activity of CD and AS was revealed (r = 0.857, P = 0.011). Significant correlation between disease activity of CD and functional limitation associated with AS was identified (r = 0.881, P Crohn disease activity index (CDAI), Bath AS disease activity index, and Bath AS functional index(BASFI) scores (r = 0.73-0.93, P Disease activity of CD correlates with disease activity of AS and functional limitation caused by AS. CRP, ESR, and Alb/Glo may serve as biomarkers for disease activity and functional limitation in CD patients concomitant with AS, although future studies are expected.

  4. Seismic Investigations of the Murci Geothermal Field (Southern Tuscany, Italy): Preliminary Results

    Science.gov (United States)

    Riedel, M.; Alexandrakis, C.; Buske, S.

    2013-12-01

    The Monte Amiata region in the Southern Tuscany, Central Italy, describes a volcanic complex with great significance in terms of the regional fresh water supply, mining and geothermal power generation. Mainly for the latter purpose, the volcanic area of Mt Amiata has been the subject of extensive geological and geophysical research (e.g. Dini et al., 2010 and references therein). The insights from these studies have led to successful geothermal production in the Mt Amiata region since the early 1960s (e.g. Batini et al., 2003). Today's most important reservoirs in this area are the Bagnore and the Piancastagnaio fields which are both operated by the company Enel Green Power. The work presented here deals with the Murci area, another potential reservoir located about 10 km southwest of the Mt Amiata volcanic complex. Therefore, in order to get a more detailed understanding of this area, five reflection seismic profiles were carried out. We have performed on three of them a preliminary depth-migrated images, through Kirchhoff prestack depth migration (KPSDM). The vital point of depth migration algorithms is the accuracy of the velocity model that is used for the backpropagation of the seismic data. Therefore, we derived a suitable 1D starting model from nearby well logs and VSP measurements. In order to remove the large topography effects along the profiles, we then utilized first-arrival tomography for each seismic line. For the following processing we incorporated these 2D tomographic results into our starting model which compensates for static effects and improves the resolution in the near-surface area. The velocity models were then used in the application of KPSDM to the seismic data for each profile, respectively. The resulting preliminary images show a zone of high seismic reflectivity, known as the 'K-horizon' (e.g. Brogi, 2008), and could improve its geological interpretation. These promising results encourage us to proceed with deeper migration velocity

  5. Preliminary Validation of a New Clinical Tool for Identifying Problem Video Game Playing

    Science.gov (United States)

    King, Daniel Luke; Delfabbro, Paul H.; Zajac, Ian T.

    2011-01-01

    Research has estimated that between 6 to 13% of individuals who play video games do so excessively. However, the methods and definitions used to identify "problem" video game players often vary considerably. This research presents preliminary validation data for a new measure of problematic video game play called the Problem Video Game Playing…

  6. Translation of the Manchester Clinical Supervision Scale (MCSS) into Danish and a preliminary psychometric validation

    DEFF Research Database (Denmark)

    Buus, Niels; Gonge, Henrik

    2013-01-01

    for the translation of the MCSS from English into Danish and to present a preliminary psychometric validation of the Danish version of the scale. Methods included a formal translation/back-translation procedure and statistical analyses. The sample consisted of MCSS scores from 139 Danish mental health nursing staff...

  7. Preliminary Validation of a New Clinical Tool for Identifying Problem Video Game Playing

    Science.gov (United States)

    King, Daniel Luke; Delfabbro, Paul H.; Zajac, Ian T.

    2011-01-01

    Research has estimated that between 6 to 13% of individuals who play video games do so excessively. However, the methods and definitions used to identify "problem" video game players often vary considerably. This research presents preliminary validation data for a new measure of problematic video game play called the Problem Video Game…

  8. Clinical utility of color-form naming in Alzheimer's disease: preliminary evidence

    DEFF Research Database (Denmark)

    Nielsen, Niels Peter; Wiig, Elisabeth H; Warkentin, Siegbert

    2004-01-01

    Performances on Alzheimer's Quick Test color-form naming and Mini-Mental State Examination were compared for 38 adults with Alzheimer's disease and 38 age- and sex-matched normal controls. Group means differed significantly and indicated longer naming times by adults with Alzheimer's disease...... associated with Alzheimer's disease, are preliminary given the relatively small sample....

  9. Preliminary investigations of the winter ecology of Long-billed Curlews in coastal Texas

    Science.gov (United States)

    Woodin, Marc C.; Skoruppa, Mary Kay; Edwardson, Jeremy W.; Austin, Jane E.

    2012-01-01

    Since the early 1900s, the distribution of the Long-billed Curlew (Numenius americanus) has contracted dramatically in the eastern one-half of its historic range. The species has been designated as a "Bird of Conservation Concern" and focal species by the U.S. Fish and Wildlife Service, a species of concern by several states, and a "Highly Imperiled" species in the U.S. Shorebird Conservation Plan. The uncertain outlook for this species has contributed to a plethora of research on Long-billed Curlews, most of which have focused on breeding and nesting ecology of the species. Gaps remain in information about factors affecting population dynamics on the winter grounds and the linkages between Long-billed Curlew populations on the breeding range, migration routes, and winter range. To begin filling those gaps, a pilot study was done to evaluate (1) curlew use of nocturnal roost sites, (2) use of public outreach to locate curlews and contribute to preliminary assessment of foraging habitat use, (3) six different methods to capture curlews, and (4) movements by curlews on wintering areas. The study area includes the lower Texas coast, which harbors the eastern-most dense populations of Long-billed Curlews in North America.

  10. Anger self-management training for people with traumatic brain injury: a preliminary investigation.

    Science.gov (United States)

    Hart, Tessa; Vaccaro, Monica J; Hays, Christina; Maiuro, Roland D

    2012-01-01

    : To examine the feasibility and gather preliminary data on the efficacy of a fully manualized, 8-session, psychoeducational treatment for irritability and anger after traumatic brain injury (TBI), called anger self-management training (ASMT). : A total of 10 persons with moderate to severe, chronic TBI with significant cognitive impairment and elevated levels of anger and irritability participated in the study; 8 had significant others (SOs) who participated in portions of the treatment and provided pre- and posttreatment measures; 1 SO provided only data. : Two subscales of the State-Trait Anger Expression Scale-Revised and Brief Anger-Aggression Questionnaire. : Pre- to posttreatment pilot study. : There was significant improvement on all 3 measures of self-reported anger, with large effect sizes (>1.0), and on 1 of 3 SO-reported scales. Qualitative feedback from participants was positive and dropout rate was low (1 of 11). : The treatment model represented by the ASMT appears worthy of further study in persons with TBI who have both problematic anger and cognitive impairment.

  11. Preliminary investigation of force-reduced superconducting magnet configurations for advanced technology applications

    Energy Technology Data Exchange (ETDEWEB)

    Bouillard, J.X.

    1992-12-01

    The feasibility of new high-field low specific weight superconducting magnet designs using force-free fields is being explored analytically and numerically. This report attempts to assess the technical viability of force-free field concepts to produce high-field, low specific weight and large bore volume magnets, which could promote the use of high temperature superconductors. Several force-free/force-reduced magnet configurations are first reviewed, then discussed and assessed. Force-free magnetic fields, fields for which the current flows parallel to the field, have well-known mathematical solutions extending upon infinite domains. These solutions, however, are no longer force-free everywhere for finite geometries. In this preliminary study, force-free solutions such as the Lundquist solutions truncated to a size where the internal field of the coil matches an externally cylindrical magnetic field (also called a Lundquist coil) are numerically modeled and explored. Significant force-reduction for such coils was calculated, which may have some importance for the design of lighter toroidal magnets used in thermonuclear fusion power generation, superconducting magnetic energy storage (SMES), and mobile MHD power generation and propulsion.

  12. Preliminary investigation of interconnected systems interactions for the safety injection system of Indian Point-3

    Energy Technology Data Exchange (ETDEWEB)

    Alesso, H.P.; Lappa, D.A.; Smith, C.F.; Sacks, I.J.

    1983-03-04

    The rich diversity of ideas and techniques for analyzing interconnected systems interaction has presented the NRC with the problem of identifying methods appropriate for their own review and audit. This report presents the findings of a preliminary study using the Digraph Matrix Analysis method to evaluate interconnected systems interactions for the safety injection system of Indian Point-3. The analysis effort in this study was subjected to NRC constraints regarding the use of Boolean logic, the construction of simplified plant representations or maps, and the development of heuristic measures as specified by the NRC. The map and heuristic measures were found to be an unsuccessful approach. However, from the effort to model and analyze the Indian Point-3 safety injection system, including Boolean logic in the model, singleton and doubleton cut-sets were identified. It is recommended that efforts excluding Boolean logic and utilizing the NRC heuristic measures not be pursed further and that the Digraph Matrix approach (or other comparable risk assessment technique) with Boolean logic included to conduct the audit of the Indian Point-3 systems interaction study.

  13. Neuropsychological presentation and adaptive skills in high-functioning adolescents with visual impairment: A preliminary investigation.

    Science.gov (United States)

    Greenaway, R; Pring, L; Schepers, A; Isaacs, D P; Dale, N J

    2017-01-01

    Studies in infants and young children with congenital visual impairment (VI) have indicated early developmental vulnerabilities, conversely research with older children and adults have highlighted areas of cognitive strength. A minimal amount is known, however, about the possible combination of strengths and weaknesses in adolescence, and this present study therefore aims to explore the neuropsychological presentation and adaptive behavior profile in high-functioning adolescents with congenital VI. Participants completed a battery of commonly used neuropsychological measures assessing memory, executive function, and attention. The measures utilized focused on auditory neuropsychological function, because only subtests that could be completed with auditory administration were suitable for this sample. Parents completed standardized measures of adaptive behavior, executive function, and social communication. Compared to aged-based norms for normal sight, adolescents with VI demonstrated strengths in aspects of working memory and verbal memory. Furthermore, performance across the neuropsychological battery was within or above the average range for the majority of the sample. In contrast, parent-report measures indicated areas of weakness in adaptive functioning, social communication, and behavioral executive functioning. Overall, this study provides preliminary evidence that relative to fully sighted peers, high-functioning adolescents with VI present with an uneven profile of cognitive and adaptive skills, which has important implications for assessment and intervention.

  14. Examining emotional modulation of pain and spinal nociception in Native Americans: a preliminary investigation.

    Science.gov (United States)

    Palit, Shreela; Kerr, Kara L; Kuhn, Bethany L; DelVentura, Jennifer L; Terry, Ellen L; Bartley, Emily J; Shadlow, Joanna O; Rhudy, Jamie L

    2013-11-01

    Pain problems are more prevalent in Native Americans than in any other group in the U.S., and this might result from group differences in pain modulation. This study was designed to examine emotional modulation of pain and spinal nociception in healthy, pain-free Native Americans (n = 21) relative to non-Hispanic Whites (n = 20). To assess emotional modulation of pain and the nociceptive flexion reflex (NFR, a physiological measure of spinal nociception), participants underwent a well-validated emotional picture-viewing paradigm during which suprathreshold pain stimuli were delivered to the ankle. Compared to Whites, Native Americans reported less pleasure to erotic pictures and failed to show corrugator reactivity to mutilation pictures. Unlike Whites, Native Americans only evidenced pain inhibition in response to erotica, but no pain facilitation (disinhibition) to mutilation pictures. Emotional modulation of NFR was similar in both groups. These preliminary findings suggest that Native Americans failed to disinhibit pain, perhaps due to over-activation of pain inhibitory mechanisms. Chronic over-activation of this system could ultimately exhaust it, thus putting Native Americans at future risk for chronic pain.

  15. Preliminary investigation of an ultrasound method for estimating pressure changes in deep-positioned vessels

    Science.gov (United States)

    Olesen, Jacob Bjerring; Villagomez-Hoyos, Carlos Armando; Traberg, Marie Sand; Chee, Adrian J. Y.; Yiu, Billy Y. S.; Ho, Chung Kit; Yu, Alfred C. H.; Jensen, Jørgen Arendt

    2016-04-01

    This paper presents a method for measuring pressure changes in deep-tissue vessels using vector velocity ultrasound data. The large penetration depth is ensured by acquiring data using a low frequency phased array transducer. Vascular pressure changes are then calculated from 2-D angle-independent vector velocity fields using a model based on the Navier-Stokes equations. Experimental scans are performed on a fabricated flow phantom having a constriction of 36% at a depth of 100 mm. Scans are carried out using a phased array transducer connected to the experimental scanner, SARUS. 2-D fields of angle-independent vector velocities are acquired using directional synthetic aperture vector flow imaging. The obtained results are evaluated by comparison to a 3-D numerical simulation model with equivalent geometry as the designed phantom. The study showed pressure drops across the constricted phantom varying from -40 Pa to 15 Pa with a standard deviation of 32%, and a bias of 25% found relative to the peak simulated pressure drop. This preliminary study shows that pressure can be estimated non-invasively to a depth that enables cardiac scans, and thereby, the possibility of detecting the pressure drops across the mitral valve.

  16. A phenomenographic investigation into Information Literacy in nursing practice - preliminary findings and methodological issues.

    Science.gov (United States)

    Forster, Marc

    2013-10-01

    Information Literacy is essential to 'evidence-based practice'; without the ability to locate evidence, evidence-based practice is rendered extremely difficult if not impossible. There is currently little evidence to show how Information Literacy is experienced by nurses or what its parameters are within evidence-based practice and therefore whether Information Literacy educational interventions are actually promoting the correct knowledge and skills. Using phenomenographic interviews the author will attempt to discover how nurses experience Information Literacy. Insights from the findings will be used to map out its parameters and to put forward a theoretical model for a course or module to develop it effectively. This article presents preliminary findings, including 7 draft categories of description of how Information Literacy is experienced in nursing. This pilot study indicates that the complete findings may be of significant potential value in the promotion and development of Information Literacy education in nursing. It is argued that such insights into how nurses actually experience the phenomenon of Information Literacy can be used to develop potentially more effective, research-based, educational interventions. Copyright © 2012 Elsevier Ltd. All rights reserved.

  17. Synthesis, Characterization, and Preliminary Investigation of Cell Interaction of Magnetic Nanoparticles with Catechol-Containing Shells

    Science.gov (United States)

    Wagner, Kerstin; Seemann, Thomas; Wyrwa, Ralf; Clement, Joachim H.; Müller, Robert; Nietzsche, Sandor; Schnabelrauch, Matthias

    2010-12-01

    Superparamagnetic iron oxide cores were synthesized by co-precipitation of Fe(II) and Fe(III) salts and subsequently stabilized by coating with different catechols (levodopa, dopamine, hydrocaffeic acid, dopamine-containing carboxymethyl dextran) known to act as high-affinity, bidentate ligands for Fe(III). The prepared stable magnetic fluids were characterized with regard to their chemical composition (content of iron and shell material, Fe(II)/Fe(III) ratio) and their physical properties (size, surface charge, magnetic parameters). The nanoparticles showed no or only slight cytotoxic effects within 1 and 4 days of incubation with 3T3 fibroblast cells. Preliminary experiments were performed to study the interaction of the prepared nanoparticles with human MCF-7 breast cancer cells and leukocytes. An intense interaction of the MCF-7 cells with these particles was found whereas the leukocytes showed a lower tendency of interaction. Based on these finding, the novel magnetic nanoparticles possess the potential for use in depletion of tumor cells from peripheral blood.

  18. Preliminary investigation of naringenin hydroxylation with recombinant E. coli expressing plant flavonoid hydroxylation gene.

    Science.gov (United States)

    Amor, Ilef Limem-Ben; Salem, Nidhal; Guedon, Emmanuel; Engasser, Jean-Marc; Chekir-Ghedrira, Leila; Ghoul, Mohamed

    2010-05-01

    Flavonoid hydroxylation is one way to increase the biological activities of these molecules and the number of hydroxyl groups needed for polymerization, esterification, alkylation, glycosylation and acylation reactions. These reactions have been suggested as a promising route to enhance flavonoid solubility and stability. In our preliminary study we hydroxylated naringenin (the first flavonoid core synthesized in plants) with recombinant E. coli harboring flavanone 3 hydroxylase (F3H). We demonstrated that recombinant E. coli harboring the F3H from Petroselinum crispum, can convert naringenin to dihydrokaempferol. The whole cell hydroxylase activity was often influenced by the stability of the plasmid harboring the cloned gene and the biomass yield. When the composition of the growth media became richer the amount of formed product decreased about twofold; the naringenin bioconversion yield in LB media was 70% and decreased to 33% in TB. However, the enrichment of culture media increased the biomass yield nearly threefold in LB media, only 0.5 g/L of bacteria was formed, but in TB there was 1.6 g/L. Thus, LB constitutes the best medium for naringenin bioconversion using the recombinant E. coli harboring the F3H; this allows for maximum bioconversion yield and plasmid stability when compared with the fourth tested culture medium. Consequently, E. coli harboring F3H from Petroselinum crispum can be used to produce flavonoids hydroxylated in position 3 that can serve in additional reactions like polymerization, glycosylation, and acylation,

  19. An 8-week reactive balance training program in older healthy adults:A preliminary investigation

    Institute of Scientific and Technical Information of China (English)

    Max R. Paquette; Yuhua Li; Joseph Hoekstra; Joshua Bravo

    2015-01-01

    Background:This preliminary study examined the effects of an 8-week supervised reactive balance training program on reaction time (RT) and foot speed, static balance and balance confidence in healthy older adults compared to an exercise control group. Methods:Twenty-five older adults were randomly assigned to a reactive balance training group (QuickBoard;n=12;71.0 ± 8.6 years) or a stationary cycling group (control; n = 13; 70.2 ± 6.0 years). Both groups were tested for foot RT foot speed, static balance, and balance confidence at baseline, 4-week, 8-week, and 4-week follow-up. Results: Results indicated significant improvements in QuickBoard foot RT and speed in both groups with greater improvements in the QuickBoard group. However, no group difference was found in static balance performance. Conclusion: Although the improvements in RT and foot speed may be beneficial for fall and trip prevention, the implications of the current findings for trip avoidance and performance of daily tasks are unclear.

  20. Investigation of tunable LED lighting for general illumination employing preliminary activity recognition sensor network

    Science.gov (United States)

    Thompson, Maria; Spaulding, Jeremy; Larson, Kent; Hall, Harrison

    2011-10-01

    Digitally controlled solid state lighting systems can afford a range of different qualities of light, adjustable to users' requirements. Sensor networks allow lighting changes to be actuated in response to the location, activities, and paths of the occupants. This paper reports initial results of an ongoing research to explore strategic control of a tunable LED system, in response to a preliminary activity recognition platform, as well as the associated human factors. Tunable LED panels connected to a sensor network were installed to illuminate three distinct occupied spaces: a private office, a public office space and a corridor at MIT Media Lab. Human factors experiments were conducted to assess visual acceptability under changing lighting conditions. In the first phase variations in color rendering were applied to verify perception of subtle changes in white lighting. Results from this phase indicate that it is possible to correlate activities with sensitivity to spectral change. In the second phase the question is how colored light can be used for energy savings and as a communication medium in these commercial spaces.

  1. Preliminary investigation of flow dynamics during the start-up of a bulb turbine model

    Science.gov (United States)

    Coulaud, M.; Fraser, R.; Lemay, J.; Duquesne, P.; Aeschlimann, V.; Deschênes, C.

    2016-11-01

    Nowadays, the electricity network undergoes more perturbations due to the market demand. Additionally, an increase of the production from alternative resources such as wind or solar also induces important variations on the grid. Hydraulic power plants are used to respond quickly to these variations to stabilize the network. Hydraulic turbines have to face more frequent start-up and stop sequences that might shorten significantly their life time. In this context, an experimental analysis of start-up sequences has been conducted on the bulb turbine model of the BulbT project at the Hydraulic Machines Laboratory (LAMH) of Laval University. Maintaining a constant head, guide vanes are opened from 0 ° to 30 °. Three guide vanes opening speed have been chosen from 5 °/s to 20 °/s. Several repetitions were done for each guide vanes opening speed. During these sequences, synchronous time resolved measurements have been performed. Pressure signals were recorded at the runner inlet and outlet and along the draft tube. Also, 25 pressure measurements and strain measurements were obtained on the runner blades. Time resolved particle image velocimetry were used to evaluate flowrate during start-up for some repetitions. Torque fluctuations at shaft were also monitored. This paper presents the experimental set-up and start-up conditions chosen to simulate a prototype start-up. Transient flowrate methodology is explained and validation measurements are detailed. The preliminary results of global performances and runner pressure measurements are presented.

  2. Blood pressure changes in African American patients receiving chiropractic care in a teaching clinic: a preliminary study.

    Science.gov (United States)

    McMasters, Kim L; Wang, Joe; York, Jennifer; Hart, John; Neely, Cheneir; Delain, Rochelle J

    2013-06-01

    The purpose of this preliminary study was to determine if a course of chiropractic care would change blood pressure measurements in African American patients and to determine if a study was feasible in a chiropractic teaching clinic. Twenty-four African American patients received chiropractic care in a chiropractic teaching clinic over a study period that spanned 23 visits for each patient. Inclusion criteria consisted of patients having a diagnosis of prehypertension (120-139/80-89) or hypertension stage 1 (140-159/90-99). The mean values of 3 baseline blood pressure readings were compared with the mean values of blood pressure readings taken on visits 21, 22, and 23. For the entire sample, reductions for both systolic and diastolic blood pressures were not statistically significant (P > .07). When 4 patients having body mass index values that were considered as outliers were excluded, a statistically significant decrease in diastolic blood pressure was observed (P = .004). By group, a statistically significant reduction occurred in the hypertension stage 1 group for systolic and diastolic blood pressures. This study showed that research of this nature may be feasible in chiropractic teaching clinics. The preliminary findings of this study showed that, for a subgroup of African American patients receiving chiropractic care, blood pressure decreased for (a) hypertension stage 1 patients and (b) the sample when those with excessive body mass index were excluded.

  3. 多中心、前瞻性中国心力衰竭注册登记研究——病因、临床特点和治疗情况初步分析%China Heart Failure Registry Study——A Multicenter, Prospective Investigation for Preliminary Analysis on Etiology, Clinical Features and Treatment in Heart Failure Patients

    Institute of Scientific and Technical Information of China (English)

    张健; 张宇辉

    2015-01-01

    Objective: China Heart Failure Registry Study (China-HF) is aimed to understand the etiology, clinical features and treatment of in-hospital heart failure (HF) patients in China. Methods: Based on geographic region and economic condition, we prospectively recruited the in-hospital patients with primarily diagnosed HF, and the demographic information, etiology, clinical features and treatment condition were collected by electronic case report form in all patients. Results: A total of 8516 HF patients from 88 participating hospitals between 2012-01 and 2014-12 were analyzed. The average age of patients was at 66 years with 54.5% male. There were 6777/7997 (84.7%) patients with NYHA functional classiifcation at III-IV, 4207/8516 (49.4%) with coronary artery disease (CAD), 4649 (54.6%) with hypertension, 2109/7102 (29.7%) with chronic kidney disease and 2478/6608 (37.5%) with left ventricular ejection fraction (LVEF) < 40%. The patients with infection 3909/8516 (45.9%) and exertion or stress 2214 (26.0%) and myocardial ischemia 1967 (23.1%) were the major cause of HF worsening. There were 6165/8516 (72.4%) patients treated by intravenous diuretics during hospitalization, and after discharge, 5722 (67.2%) patients received oral loop diuretics, 2563 (30.1%) received angiotensin converting enzyme inhibitor, 2095 (24.6%) received angiotensin II receptor antagonist. The median length of in-hospital stay was 11 days and the in-hospital mortality was 5.3% (451/8516). Conclusion: China-HF provides a comprehensive insight of clinical features for the in-hospital HF patients in China. There is still a gap for medications between our current condition and the guideline, it is important to educate both patients and physicians in clinical practice.%目的:了解中国住院心力衰竭(心衰)患者病因、临床特点和治疗情况.方法:根据地域及经济分布前瞻性入选因心衰住院的患者.通过电子病例报告表收集患者的人口学信

  4. Hypothalamic-Ptuitary-Adrenal (HPA) Axis Activity in Adults with Intellectual Disabilities: A Preliminary Investigation

    Science.gov (United States)

    Presland, A. D.; Clare, I. C. H.; Broughton, S.; Luke, L.; Wheeler, E.; Fairchild, G.; Watson, P. C.; Chan, W. Y. S.; Kearns, A.; Ring, H. A.

    2013-01-01

    Background: Cortisol is a marker of physiological arousal, exhibiting a characteristic pattern of diurnal activity. The daily cortisol profile has been examined extensively and is atypical in a number of clinical disorders. However, there are very few studies focussing on the cortisol profile in adults with intellectual disabilities (ID). This…

  5. Preliminary results of paleoseismic investigations of Quaternary faults on eastern Yucca Mountain, Nye County, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Menges, C.M.; Oswald, J.A.; Coe, J.A. [and others

    1995-12-31

    Site characterization of the potential nuclear waste repository at Yucca Mountain, Nevada, requires detailed knowledge of the displacement histories of nearby Quaternary faults. Ongoing paleoseismic studies provide data on the amount and rates of Quaternary activity on the Paintbrush Canyon, Bow Ridge, and Stagecoach Road faults along the eastern margin of the mountain over varying time spans of 0-700 ka to perhaps 0-30 ka, depending on the site. Preliminary stratigraphic interpretations of deposits and deformation at many logged trenches and natural exposures indicate that each of these faults have experienced from 3 to 8 surface-rupturing earthquakes associated with variable dip-slip displacements per event ranging from 5 to 115 cm, and commonly in the range of 20 to 85 cm. Cumulative dip-slip offsets of units with broadly assigned ages of 100-200 ka are typically less than 200 cm, although accounting for the effects of possible left normal-oblique slip could increase these displacements by factors of 1.1 to 1.7. Current age constraints indicate recurrence intervals of 10{sup 4} to 10{sup 5} years (commonly between 30 and 80 k.y.) and slip rates of 0.001 to 0.08 mm/yr (typically 0.01-0.02 mm/yr). Based on available timing data, the ages of the most recent ruptures varies among the faults; they appear younger on the Stagecoach Road Fault ({approximately}5-20 ka) relative to the southern Paintbrush Canyon and Bow Ridge faults ({approximately}30-100 ka).

  6. Preliminary results of paleoseismic investigations of Quaternary faults on eastern Yucca Mountain, Nye County, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Menges, C.M.; Oswald, J.A.; Coe, J.A.; Whitney, J.W. [Geological Survey, Denver, CO (United States); Swan, F.H.; Wesling, J.R.; Thomas, A.P. [Geomatrix Consultants, San Francisco, CA (United States)

    1994-12-31

    Site characterization of the potential nuclear waste repository at Yucca Mountain, Nevada, requires detailed knowledge of the displacement histories of nearby Quaternary faults. Ongoing paleoseismic studies provide data on the amount and rates of Quaternary activity on the Paintbrush Canyon, Bow Ridge, and Stagecoach Road faults along the eastern margin of the mountain over varying time spans of 0-700 ka to perhaps 0-30 ka, depending on the site. Preliminary stratigraphic interpretations of deposits and deformation at many logged trenches and natural exposures indicate that each of these faults have experienced from 3 to 8 surface-rupturing earthquakes associated with variable dip-slip displacements per event ranging from 5 to 115 cm, and commonly in the range of 20 to 85 cm. Cumulative dip-slip offsets of units with broadly assigned ages of 100-200 ka are typically less than 200 cm, although accounting for the effects of possible left normal-oblique slip could increase these displacements by factors of 1.1 to 1.7. Current age constraints indicate recurrence intervals of 10{sup 4} to 10{sup 5} years (commonly between 30 and 80 k.y.) and slip rates of 0.001 to 0.08 mm/yr (typically 0.01-0.02 mm/yr). Based on available timing data, the ages of the most recent ruptures among the faults; they appear younger on the Stagecoach Road Fault ({approximately} 5.20 ka) relative to the southern Paintbrush Canyon and Bow Ridge faults ({approximately} 30-100 ka).

  7. Diffusion-weighted imaging in assessing renal pathology of chronic kidney disease: A preliminary clinical study

    Energy Technology Data Exchange (ETDEWEB)

    Li, Qinghai; Li, Jinning; Zhang, Lan; Chen, Ying; Zhang, Minming [Department of Radiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009 (China); Yan, Fuhua, E-mail: zemylife@163.com [Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025 (China)

    2014-05-15

    Objective: To investigate the clinical potential of diffusion-weighted imaging (DWI) in assessing renal pathology of chronic kidney disease (CKD). Methods: Seventy-one CKD patients and twelve healthy volunteers were examined using DWI with prospective acquisition correction. Renal biopsy specimens from the CKD patients were scored based on the severity of renal pathology and to confirm pathology type. CKD patients were divided into three groups according to pathology scores: mild, moderate, or severe. The association between renal apparent diffusion coefficient (ADC) values and pathology scores was investigated using Pearson's correlation and single factor analysis of variance. Multiple linear regression analysis was performed to explore associations between renal ADC values and pathology score, glomerular filtration rate, serum creatinine, and age. The Kruskal–Wallis H test was conducted to compare ADC values and pathology type. Results: Renal ADC values correlated negatively with pathology scores (r = −0.633, P < 0.001). The ADC values among the four groups (mild, moderate, severe impairment, and controls) were significantly different (F = 19.512, P < 0.001). However, when patients were stratified by pathology type, no significant differences were found in ADC values among these groups (χ{sup 2} = 9.929, P = 0.270). Further multiple linear regression analysis showed that only the pathology score and ADC values were related (t = −4.586, P = 0.000). Conclusions: DWI has clinical potential in assessing the severity of renal pathology in CKD and shows promise as a non-invasive and effective technique to guide therapy and follow-up.

  8. Alu Insertions and Genetic Diversity: A Preliminary Investigation by an Undergraduate Bioinformatics Class

    Science.gov (United States)

    Elwess, Nancy L.; Duprey, Stephen L.; Harney, Lindesay A.; Langman, Jessie E.; Marino, Tara C.; Martinez, Carolina; McKeon, Lauren L.; Moss, Chantel I. E.; Myrie, Sasha S.; Taylor, Luke Ryan

    2008-01-01

    "Alu"-insertion polymorphisms were used by an undergraduate Bioinformatics class to study how these insertion sites could be the basis for an investigation in human population genetics. Based on the students' investigation, both allele and genotype "Alu" frequencies were determined for African-American and Japanese populations as well as a…

  9. Is less more? A preliminary investigation of the number of response categories in self-reported pain

    Directory of Open Access Journals (Sweden)

    Karon F Cook

    2010-05-01

    Full Text Available Karon F Cook1, David Cella2, Erin L Boespflug1, Dagmar Amtmann11Department of Rehabilitation Medicine, University of Washington, Seattle, WA; 2Department of Medical Social Sciences, Northwestern University, Feinberg School of Medicine, Chicago, IL, USAAbstract: The purpose of this study was to conduct a preliminary investigation of the number of response options for self-reports of pain interference. Responses to interference items of the 11-category Brief Pain Inventory (BPI were obtained in a sample of 434 persons from two sites and modeled using the partial credit model. In successive calibrations, response categories were collapsed and new scores were generated. Scores based on two to three categories produced poor results. Four to five categories yielded better results. However, scoring using more than five categories did not appreciably improve the reliability, person separation, or validity of scores. These results suggest that fewer response categories—as few as five or six–may function as well as the 11 response categories that are conventionally used. The results are preliminary since the number of response categories actually presented was not manipulated in the study design. Future research should compare the reliability and validity of scores based on the BPI interference items when items are presented with the conventionally 11-response format, versus presentation with fewer response options.Keywords: psychometrics, outcomes, quality of life, measurement, pain

  10. Investigating the role of combined acoustic-visual feedback in one-dimensional synchronous brain computer interfaces, a preliminary study

    Science.gov (United States)

    Gargiulo, Gaetano D; Mohamed, Armin; McEwan, Alistair L; Bifulco, Paolo; Cesarelli, Mario; Jin, Craig T; Ruffo, Mariano; Tapson, Jonathan; van Schaik, André

    2012-01-01

    Feedback plays an important role when learning to use a brain computer interface (BCI), particularly in the case of synchronous feedback that relies on the interaction subject. In this preliminary study, we investigate the role of combined auditory-visual feedback during synchronous μ rhythm-based BCI sessions to help the subject to remain focused on the selected imaginary task. This new combined feedback, now integrated within the general purpose BCI2000 software, has been tested on eight untrained and three trained subjects during a monodimensional left-right control task. In order to reduce the setup burden and maximize subject comfort, an electroencephalographic device suitable for dry electrodes that required no skin preparation was used. Quality and index of improvement was evaluated based on a personal self-assessment questionnaire from each subject and quantitative data based on subject performance. Results for this preliminary study show that the combined feedback was well tolerated by the subjects and improved performance in 75% of the naïve subjects compared with visual feedback alone. PMID:23152713

  11. QSAR models for reproductive toxicity and endocrine disruption in regulatory use - a preliminary investigation

    DEFF Research Database (Denmark)

    Jensen, Gunde Egeskov; Niemela, J.R.; Wedebye, Eva Bay

    2008-01-01

    the new legislation. This article focuses on a screening exercise by use of our own and commercial QSAR models for identification of possible reproductive toxicants. Three QSAR models were used for reproductive toxicity for the endpoints teratogenic risk to humans (based on animal tests, clinical data...... for humans owing to possible developmental toxic effects: Xn (Harmful) and R63 (Possible risk of harm to the unborn child). The chemicals were also screened in three models for endocrine disruption....

  12. A preliminary investigation of materialism and impulsiveness as predictors of technological addictions among young adults

    National Research Council Canada - National Science Library

    Roberts, James A; Pirog, 3rd, Stephen F

    2013-01-01

    Background and aims The primary objective of the present research is to investigate the drivers of technological addiction in college students - heavy users of Information and Communication Technology (ICT...

  13. Root surface strain during canal shaping and its influence on apical microcrack development: a preliminary investigation.

    Science.gov (United States)

    Jamleh, A; Komabayashi, T; Ebihara, A; Nassar, M; Watanabe, S; Yoshioka, T; Miyara, K; Suda, H

    2015-12-01

    shaping was poorly correlated with the number of microcracks found (R(2)  = 0.093). Based on these preliminary data, canal shaping appears to cause apical microcracks regardless of the type of rotary instrument motion. Contrast-enhanced micro-CT was able to identify microcracks in roots. © 2014 International Endodontic Journal. Published by John Wiley & Sons Ltd.

  14. A Preliminary Genetic Investigation of Rastrelliger Kanagurta Based on Random Amplified Polymorphic DNA and Mitochondrial ND2 Gene

    Institute of Scientific and Technical Information of China (English)

    Siti Azizah Mohd Nor; Abu Talib A; Mohd Ghows M A; Samsudin B

    2008-01-01

    In a preliminary investigation, Random Amplified Polymorphie DNA (RAPD) analysis and partial mitochon-drial ND2 gene sequencing were conducted to study the genetic variation of the Indian mackerel, Rastrelliger kanagurta along a 450 km stretch of its distribution on the west coast of Peninsular Malaysia. A total of 53 individuals from 6 popu-lations were analyzed using 4 RAPD primers and a sub-sample of 15 individuals was chosen for sequencing of partial ND2 gene. Comparison between the 2 markers revealed genetic structuring in the RAPD results but genetic homogeneity for ND2 gene. Based on the former there may be at least 2 genetically differentiated groups of Rastrelliger kanagurta a-long this stretch.

  15. In vitro and in vivo antitumor activity of Bulbus Fritillariae Cirrhosae and preliminary investigation of its mechanism.

    Science.gov (United States)

    Wang, Dong-Dong; Feng, Yong; Li, Zu; Zhang, Li; Wang, Shu; Zhang, Chao-Yang; Wang, Xiao-Xia; Liu, Zi-Yu

    2014-01-01

    Bulbus Fritillariae Cirrhosae (BFC) is widely used in China both for food and folk medicine because of its powerful biological activities. Firstly, this study was designed to examine the antiproliferative activities of the different fractions from BFC in vitro by MTT assay. The results showed that chloroform extracts (CE) and the purified total alkaloids of BFC (TAF) exhibited stronger antiproliferative activity than the other fractions. We further determined the total alkaloids and 3 main alkaloids monomers content of CE and TAF by UV and HPLC-ELSD methods, respectively. Moreover, we assessed the antitumor activity of TAF in vivo and made preliminary investigation of its antitumor mechanism by histological and immunohistochemical staining technique. These results demonstrate that TAF showed significant antitumor activity and low toxicity in vivo. Meanwhile, TAF significantly inhibited tumor angiogenesis and induced apoptosis by improvement of expression level of caspase-3. These results suggest that alkaloids of BFC could hold a good potential for use as an antitumor drug.

  16. Preliminary experimental investigation of an X-band Cerenkov-type high power microwave oscillator without guiding magnetic field

    Science.gov (United States)

    Guo, Liming; Shu, Ting; Li, Zhiqiang; Ju, Jinchuan; Fang, Xiaoting

    2017-02-01

    Among high power microwave (HPM) generators without guiding magnetic field, Cerenkov-type oscillator is expected to achieve a relatively high efficiency, which has already been realized in X-band in our previous simulation work. This paper presents the preliminary experimental investigations into an X-band Cerenkov-type HPM oscillator without guiding magnetic field. Based on the previous simulation structure, some modifications regarding diode structure were made. Different cathode structures and materials were tested in the experiments. By using a ring-shaped graphite cathode, microwave of about one hundred megawatt level was generated with a pure center frequency of 9.14 GHz, and an efficiency of about 1.3%. As analyzed in the paper, some practical issues reduce the efficiency in experiments, such as real features of the electron beam, probable breakdown regions on the cathode surface which can damage the diode, and so forth.

  17. Preliminary investigation on monitoring transportation effects by full field methods: a digital holographic speckle pattern interferometry study on canvas paintings

    Science.gov (United States)

    Tsiranidou, Elsa; Bernikola, Eirini; Tornari, Vivi; Fankhauser, Thomas; Läuchli, Matthias; Palmbach, Cornelius; Bäschlin, Nathalie

    2011-06-01

    A preliminary investigation has taken place employing Digital Holographic Speckle Pattern Interferometry (DHSPI) in order to assess the effect of handling and transportation on canvas paintings. Canvas dummies were used on a series of measurements on a transport simulator which allows reproducible simulation of any transport logs in the laboratory. A number of cycles of controlled vibrations were applied on the samples and after each cycle a measurement with DHSPI was taken to monitor the behavior of the samples while increasing the vibration loading and also to record the conditions under which the first crack appears. The transport simulations in combination with DHSPI monitoring revealed the amplitude of oscillation where the first cracks appear on new canvas paintings and also the way these cracks grow. During the tests it was also feasible to locate areas at risk of future deterioration.

  18. Preliminary investigations of hydrogen peroxide treatment of selected ornamental fishes and efficacy against external bacteria and parasites in green swordtails.

    Science.gov (United States)

    Russo, Riccardo; Curtis, Eric W; Yanong, Roy P E

    2007-06-01

    The objectives of these preliminary studies were to evaluate the use of hydrogen peroxide (H2O2) for the treatment of selected species of ornamental fishes and its efficacy in treating external bacteria and parasites. In the first part of the study, fish of five species (serpae tetra Hyphessobrycon eques (also known as Serpa tetra H. serpae), tiger barb Puntius tetrazona, blue gourami Trichogaster trichopterus, suckermouth catfish Hypostomus plecostomus, and green swordtail Xiphophorus hellerii) were exposed to H2O2 for 1 h at concentrations between 6 and 34 mg/L or for 24 h at concentrations between 1 and 6 mg/L. The results were species specific: green swordtails tolerated all of the treatments, serpae tetras and tiger barbs were sensitive only to the highest concentration, and mortalities of suckermouth catfish and blue gourami were recorded in every treatment. In the second part of the study, clinically healthy green swordtails and fish infested with external motile rod-shaped bacteria (i.e., Ichthyobodo spp., Trichodina spp., and Gyrodactylus spp.) were treated with several concentrations of H2O2. A single H2O2 treatment of 3.1 mg/L or more for 1 h effectively eliminated external bacteria, concentrations of 6.5 mg/L or more appeared to effectively kill Ichthyobodo spp., and none of the treatments tested was effective against Trichodina spp. or Gyrodactylus spp. These preliminary findings suggest that H2O2 is effective for treating certain external bacterial infections and flagellate infestations in some species of ornamental fish at the dosages tested. Other treatment regimens may need to be tested for effectiveness against Trichodina spp. and Dactylogyrus spp.

  19. Co-occurrence of personality disorders in persons with kleptomania: a preliminary investigation.

    Science.gov (United States)

    Grant, Jon E

    2004-01-01

    This study was conducted to examine the co-occurrence of personality disorders in a group of persons with kleptomania. Twenty-eight subjects with DSM-IV kleptomania were administered the Structured Clinical Interview for DSM-III-R Personality Disorders and a semistructured interview to assess demographics and clinical characteristics. Twelve subjects with kleptomania (42.9%) met criteria for at least one personality disorder. The most common were: paranoid (n = 5; 17.9%), schizoid (n = 3; 10.7%), and borderline (n = 3; 10.7%). Subjects with kleptomania combined with personality disorders had an earlier age of onset of stealing behavior (13.4 +/- 5.6 years compared with 27.4 +/- 14.2 years in those who had kleptomania only; t = 3.225; df = 26; p = .006). Severity of kleptomania symptoms did not differ among the Axis II comorbidities. Persons with kleptomania appear to have a high prevalence of personality disorders. Further studies are needed to understand the relationship of kleptomania to personality.

  20. A Preliminary Investigation of Acceptance and Commitment Therapy as a Treatment for Marijuana Dependence in Adults

    Science.gov (United States)

    Twohig, Michael P.; Shoenberger, Deacon; Hayes, Steven C.

    2007-01-01

    In this investigation, 3 adults who met criteria for marijuana dependence were treated using an abbreviated version of acceptance and commitment therapy (ACT). The treatment was delivered in eight weekly 90-min individual sessions. The effects of the intervention were assessed using a nonconcurrent multiple baseline across participants design.…

  1. A Preliminary Investigation of Phonological Encoding Skills in Children Who Stutter

    Science.gov (United States)

    Sasisekaran, Jayanthi; Brady, Alison; Stein, Jillian

    2013-01-01

    Purpose: The present study investigated phonological encoding skills in children who stutter (CWS) and those who do not (CNS). Participants were 9 CWS (M=11.8 years, SD=1.5) and 9 age and sex matched CNS (M=11.8 years, SD=1.5). Method: Participants monitored target phonemes located at syllable onsets and offsets of bisyllabic words. Performance in…

  2. Impact of Chromosome 4p- Syndrome on Communication and Expressive Language Skills: A Preliminary Investigation

    Science.gov (United States)

    Marshall, Althea T.

    2010-01-01

    Purpose: The purpose of this investigation was to examine the impact of Chromosome 4p- syndrome on the communication and expressive language phenotype of a large cross-cultural population of children, adolescents, and adults. Method: A large-scale survey study was conducted and a descriptive research design was used to analyze quantitative and…

  3. A Preliminary Investigation of Stimulus Control Training for Worry: Effects on Anxiety and Insomnia

    Science.gov (United States)

    McGowan, Sarah Kate; Behar, Evelyn

    2013-01-01

    For individuals with generalized anxiety disorder, worry becomes associated with numerous aspects of life (e.g., time of day, specific stimuli, environmental cues) and is thus under poor discriminative stimulus control (SC). In addition, excessive worry is associated with anxiety, depressed mood, and sleep difficulties. This investigation sought…

  4. 78 FR 66941 - Design Considerations for Pivotal Clinical Investigations for Medical Devices; Guidance for...

    Science.gov (United States)

    2013-11-07

    ... for Medical Devices; Guidance for Industry, Clinical Investigators, Institutional Review Boards and... entitled ``Design Considerations for Pivotal Clinical Investigations for Medical Devices.'' This document... premarket submissions for medical devices and for FDA staff who review those submissions. This...

  5. 77 FR 76049 - Draft Guidance for Industry on Electronic Source Data in Clinical Investigations; Correction

    Science.gov (United States)

    2012-12-26

    ... guidance entitled ``Electronic Source Data in Clinical Investigations.'' The document was published with an... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Electronic Source Data in Clinical Investigations; Correction AGENCY: Food and Drug Administration, HHS. ACTION: Notice;...

  6. Preliminary description of aging cats and dogs presented to a New Zealand first-opinion veterinary clinic at end-of-life.

    Science.gov (United States)

    Gates, M C; Hinds, H J; Dale, A

    2017-08-09

    AIMS To conduct a preliminary investigation into the chronic disease conditions and clinical signs present in aging New Zealand companion animals at end-of-life and to describe the timing, circumstances, and manner of death. METHODS The medical records database of a first-opinion, companion animal, veterinary practice in Auckland, New Zealand was searched to identify all canine and feline patients ≥7 years of age that were subjected to euthanasia or cremated in the period between July 2012-June 2014. The free-text medical notes were analysed for information on the circumstances surrounding the death, previous diagnoses of chronic disease conditions, and the presence of clinical signs associated with decreased quality-of-life at the time of euthanasia. RESULTS The median age at death was 15 (max 22) years for the 130 cats and 12 (max 17) years for the 68 dogs in the study sample. Euthanasia at the clinic was carried out for 119/130 (91%) cats and 62/68 (91%) dogs, with the remainder recorded as having an unassisted death. The frequency of deaths was highest during December for both cats and dogs. Cost was mentioned as an issue in the medical records for 39/181 (21.6%) patients that were subjected to euthanasia. At the time of euthanasia, 92/119 (77.3%) cats and 43/62 (69.4%) dogs were recorded as having >1 clinical sign associated with a decreased quality-of-life. Inappetence and non-specific decline were the two most commonly recorded clinical signs for both dogs and cats. Cardiovascular disease (44/130, 34%), renal failure (40/130, 31%), and malignant neoplasia (36/130, 28%) were the most common chronic disease conditions recorded for cats. Degenerative joint disease (22/68, 32%), malignant neoplasia (14/68, 21%), and cardiovascular disease (8/68, 12%) were the most common chronic disease conditions recorded for dogs. CONCLUSIONS AND CLINICAL RELEVANCE These preliminary findings highlight that aging companion animals in New Zealand frequently have chronic

  7. Do sexual offenders molest when other persons are present? A preliminary investigation.

    Science.gov (United States)

    Underwood, R C; Patch, P C; Cappelletty, G G; Wolfe, R W

    1999-07-01

    This study utilized a rough clinical survey to assess the prevalence of child molestation perpetrated in the presence of other non-collaborating persons. Survey data were gathered on 131 post-incarcerated adult sex offenders at two community treatment programs. Subjects were divided into two groups, child molesters (CMs) and nonmolesters (NCMs). Results indicated that 54.9% of the CMs had molested when another child was present, 23.9% had molested when another adult was present, and 14.2% had molested when both a child and an adult were present. Both groups implicated increased excitement, a sense of mastery, and compulsive sexual behavior as the reasons for this type of offense. Moreover, the data indicated that approximately 63% of the offenders who had not molested in the presence of other persons felt they may have progressed to that point had they not been arrested and placed in treatment. Limitations of the study are discussed.

  8. Preliminary investigation into application of problem-based learning in the practical teaching of diagnostics

    Directory of Open Access Journals (Sweden)

    Rui Z

    2015-03-01

    Full Text Available Zeng Rui,1,* Yue Rong-Zheng,2,* Qiu Hong-Yu,2 Zeng Jing,3 Wan Xue-Hong,3 Zuo Chuan41Department of Cardiovascular Diseases, 2Department of Nephrology, 3Department of Internal Medicine, 4Department of Rheumatology and Immunology, West China Hospital, School of Clinical Medicine, Sichuan University, Chengdu, People's Republic of China*These author contributed equally to this work and should both be considered first authorsBackground: Problem-based learning (PBL is a pedagogical approach based on problems. Specifically, it is a student-centered, problem-oriented teaching method that is conducted through group discussions. The aim of our study is to explore the effects of PBL in diagnostic teaching for Chinese medical students.Methods: A prospective, randomized controlled trial was conducted. Eighty junior clinical medical students were randomly divided into two groups. Forty students were allocated to a PBL group and another 40 students were allocated to a control group using the traditional teaching method. Their scores in the practice skills examination, ability to write and analyze medical records, and results on the stage test and behavior observation scale were compared. A questionnaire was administered in the PBL group after class.Results: There were no significant differences in scores for writing medical records, content of interviewing, physical examination skills, and stage test between the two groups. However, compared with the control group, the PBL group had significantly higher scores on case analysis, interviewing skills, and behavioral observation scales.Conclusion: The questionnaire survey revealed that PBL could improve interest in learning, cultivate an ability to study independently, improve communication and analytical skills, and good team cooperation spirit. However, there were some shortcomings in systematization of imparting knowledge. PBL has an obvious advantage in teaching with regard to diagnostic practice

  9. Use of thermographic imaging in clinical diagnosis of small animal: preliminary notes

    Directory of Open Access Journals (Sweden)

    Veronica Redaelli

    2014-06-01

    Full Text Available INTRODUCTION. The authors, after a description of the physics of infrared thermographic technique (IRT, analyze the reading of images and the main applications in the veterinary field, compared to the existing literature on the subject and to their experimental researches. IRT lends itself to countless applications in biology, thanks to its characteristics of versatility, lack of invasiveness and high sensitivity. Probably the major limitation to its application in the animal lies in the ease of use and in its extreme sensitivity. MATERIALS AND METHODS. From September 2009 to October 2010, the experimental investigation with the thermo camera took into consideration 110 animals (92 dogs and 18 cats, without any selection criteria. All patients were brought to the Faculty of Veterinary Medicine in Milan University by the owner, to be examined by a specialist, or to undergo one of the following diagnostic procedures: X-rays, computed tomography, or ultrasound examinations; finally some patients were brought in for surgical procedures. With the consent of the owner, 1 to 10 thermographic images were recorded from each clinical case. Results. In this first experimental investigation, thermography has shown a high sensitivity (100%, but a low specificity (44%. This figure excludes the use of thermal imaging technology to replace other imaging techniques such as radiography, computed tomography and magnetic resonance imaging. Furthermore, it does not show any ability to recognize the etiology of the disease, but only the thermal alteration, and this is restricting its use. However, this experimental study has demonstrated that thermography can be used in veterinary medicine, and specifically in dogs and cats. It is hoped that in the field of targeted diseases this technique will become an important tool for diagnostic purposes by using working protocols validated and repeatable.

  10. Isolation of flavonoids from the heartwood and resin of Prunus avium and some preliminary biological investigations.

    Science.gov (United States)

    McNulty, James; Nair, Jerald J; Bollareddy, Endreddy; Keskar, Kunal; Thorat, Amol; Crankshaw, Denis J; Holloway, Alison C; Khan, Ghaznia; Wright, Gerard D; Ejim, Linda

    2009-12-01

    An investigation of the constituents in heartwood and resin of Prunus avium is reported. A mini-library of structurally diverse flavanones and flavones was screened for human cytochrome P450 1A1, 3A4 and 19 (aromatase) inhibition, and for antifungal activity against a panel of pathogenic fungi. The defensive role of these natural plant flavonoids as antifungal phytoalexins and phytoanticipins is discussed.

  11. A Preliminary Investigation of Acceptance and Commitment Therapy as a Treatment for Marijuana Dependence in Adults

    OpenAIRE

    Twohig, Michael P.; Shoenberger, Deacon; Hayes, Steven C

    2007-01-01

    In this investigation, 3 adults who met criteria for marijuana dependence were treated using an abbreviated version of acceptance and commitment therapy (ACT). The treatment was delivered in eight weekly 90-min individual sessions. The effects of the intervention were assessed using a nonconcurrent multiple baseline across participants design. Self-reported marijuana use, confirmed through oral swabs, reached zero levels for all participants at posttreatment. At a 3-month follow-up, 1 partici...

  12. Factors associated with medical student test anxiety in objective structured clinical examinations: a preliminary study

    Science.gov (United States)

    2016-01-01

    Objectives To investigate attributes of medical students associated with their test anxiety on Objective Structured Clinical Examinations (OSCEs). Methods A cross-sectional study using a self-administered questionnaire was conducted of all Year 3 and 4 students at a private medical school in South Korea in 2014. This 53-item questionnaire consisted of factors pertaining to test anxiety on the OSCE identified from a review of relevant literature, which included students’ motivational beliefs and achievement emotions, perceived values of the OSCE, and attitude and orientation towards patients. Participants’ test anxiety levels were measured using the Korean Achievement Emotions Questionnaire. Participants rated their responses using a five-point Likert-type scale. Univariate analysis was performed to examine relationships between the variables. Results A total of 94 students completed the questionnaire (a 93% response rate). No differences in the participants’ test anxiety scores were observed across genders, entry-levels, or years in medical school. Participants’ test anxiety on the OSCE showed moderate association with their class-related achievement emotions (i.e., anxiety and boredom), where r = 0.46 and 0.32, p OSCE (r = -0.21, p OSCE. These findings have implications for developing effective educational interventions for helping students cope with such a stress by enhancing our understanding of the various factors that influence their test anxiety in OSCEs. PMID:28035056

  13. Factors associated with medical student test anxiety in objective structured clinical examinations: a preliminary study.

    Science.gov (United States)

    Kim, Kyong-Jee

    2016-12-29

    To investigate attributes of medical students associated with their test anxiety on Objective Structured Clinical Examinations (OSCEs). A cross-sectional study using a self-administered questionnaire was conducted of all Year 3 and 4 students at a private medical school in South Korea in 2014. This 53-item questionnaire consisted of factors pertaining to test anxiety on the OSCE identified from a review of relevant literature, which included students' motivational beliefs and achievement emotions, perceived values of the OSCE, and attitude and orientation towards patients. Participants' test anxiety levels were measured using the Korean Achievement Emotions Questionnaire. Participants rated their responses using a five-point Likert-type scale. Univariate analysis was performed to examine relationships between the variables. A total of 94 students completed the questionnaire (a 93% response rate). No differences in the participants' test anxiety scores were observed across genders, entry-levels, or years in medical school. Participants' test anxiety on the OSCE showed moderate association with their class-related achievement emotions (i.e., anxiety and boredom), where r = 0.46 and 0.32, p anxiety on the OSCE. These findings have implications for developing effective educational interventions for helping students cope with such a stress by enhancing our understanding of the various factors that influence their test anxiety in OSCEs.

  14. A Preliminary Investigation of a Specialized Music Therapy Model for Children with Disabilities Delivered in a Classroom Setting

    Directory of Open Access Journals (Sweden)

    Jenna Mendelson

    2016-01-01

    Full Text Available Music therapy is gaining popularity as an intervention strategy for children with developmental disabilities, including autism spectrum disorder (ASD. This study was a pilot investigation of a classroom-based music-based intervention, Voices Together®, for improving communication skills in children with ASD and children with intellectual disabilities. Four local public elementary school special education classrooms, serving 5 children with a classification of autistic disorder and 32 children with intellectual disability without autism, were randomly selected to receive one of two levels of exposure to Voices Together music therapy: “long-term” (15 weeks beginning in January 2015 (Time 1, n=14 or “short-term” (7 weeks beginning 7 weeks later in February (Time 2, n=17. Using observational ratings, investigators reliably scored participants live in terms of their level of verbal responsiveness to prompts during three songs featured each week of the program. Both groups demonstrated increases in verbal responses over time; however, only the long-term group demonstrated significant within-group increases. Preliminary findings suggest that music therapy delivered in a classroom in 45-minute weekly sessions for 15 weeks can promote improvements in verbal responsiveness among individuals with autism and other developmental disabilities. Findings warrant further investigation into the efficacy of classroom-based music therapy programs.

  15. A Preliminary Investigation of a Specialized Music Therapy Model for Children with Disabilities Delivered in a Classroom Setting.

    Science.gov (United States)

    Mendelson, Jenna; White, Yasmine; Hans, Laura; Adebari, Richard; Schmid, Lorrie; Riggsbee, Jan; Goldsmith, Ali; Ozler, Burcu; Buehne, Kristen; Jones, Sarah; Shapleton, Jennifer; Dawson, Geraldine

    2016-01-01

    Music therapy is gaining popularity as an intervention strategy for children with developmental disabilities, including autism spectrum disorder (ASD). This study was a pilot investigation of a classroom-based music-based intervention, Voices Together®, for improving communication skills in children with ASD and children with intellectual disabilities. Four local public elementary school special education classrooms, serving 5 children with a classification of autistic disorder and 32 children with intellectual disability without autism, were randomly selected to receive one of two levels of exposure to Voices Together music therapy: "long-term" (15 weeks beginning in January 2015 (Time 1), n = 14) or "short-term" (7 weeks beginning 7 weeks later in February (Time 2), n = 17). Using observational ratings, investigators reliably scored participants live in terms of their level of verbal responsiveness to prompts during three songs featured each week of the program. Both groups demonstrated increases in verbal responses over time; however, only the long-term group demonstrated significant within-group increases. Preliminary findings suggest that music therapy delivered in a classroom in 45-minute weekly sessions for 15 weeks can promote improvements in verbal responsiveness among individuals with autism and other developmental disabilities. Findings warrant further investigation into the efficacy of classroom-based music therapy programs.

  16. A Preliminary Investigation of a Specialized Music Therapy Model for Children with Disabilities Delivered in a Classroom Setting

    Science.gov (United States)

    White, Yasmine; Hans, Laura; Adebari, Richard; Goldsmith, Ali; Ozler, Burcu; Buehne, Kristen; Jones, Sarah; Shapleton, Jennifer

    2016-01-01

    Music therapy is gaining popularity as an intervention strategy for children with developmental disabilities, including autism spectrum disorder (ASD). This study was a pilot investigation of a classroom-based music-based intervention, Voices Together®, for improving communication skills in children with ASD and children with intellectual disabilities. Four local public elementary school special education classrooms, serving 5 children with a classification of autistic disorder and 32 children with intellectual disability without autism, were randomly selected to receive one of two levels of exposure to Voices Together music therapy: “long-term” (15 weeks beginning in January 2015 (Time 1), n = 14) or “short-term” (7 weeks beginning 7 weeks later in February (Time 2), n = 17). Using observational ratings, investigators reliably scored participants live in terms of their level of verbal responsiveness to prompts during three songs featured each week of the program. Both groups demonstrated increases in verbal responses over time; however, only the long-term group demonstrated significant within-group increases. Preliminary findings suggest that music therapy delivered in a classroom in 45-minute weekly sessions for 15 weeks can promote improvements in verbal responsiveness among individuals with autism and other developmental disabilities. Findings warrant further investigation into the efficacy of classroom-based music therapy programs. PMID:27999683

  17. Trace elements in urinary stones: a preliminary investigation in Fars province, Iran.

    Science.gov (United States)

    Keshavarzi, Behnam; Yavarashayeri, Nasrin; Irani, Dariush; Moore, Farid; Zarasvandi, Alireza; Salari, Mehrdad

    2015-04-01

    In view of the high incidence rate of urinary stones in the south and southwest of Iran, this paper investigates trace elements content including heavy metals in 39 urinary stones, collected from patients in Fars province, Iran. The mineralogy of the stones is investigated using X-ray diffractometry. The samples are classified into five mineral groups (calcium oxalate, uric acid, cystine, calcium phosphate and mixed stone). Major and trace elements in each group were determined using ICP-MS method. P and Ca constitute the main elements in urinary stones with Ca being more affine to oxalates while other alkali and alkaline earths precipitate with phosphate. Significant amounts of trace elements, especially Zn and Sr, were found in urinary calculi (calcium oxalate and phosphates) relative to biominerals (uric acid and cystine). Among urinary calculi, calcium phosphate contains greater amounts of trace metal than calcium oxalate. Phosphates seem to be the most important metal-bearing phases in urinary stones. Results indicate that concentrations of elements in urinary stones depend on the type of mineral phases. Significant differences in elements content across various mineralogical groups were found by applying statistical methods. Kruskal-Wallis test reveals significant difference between Ca, P, K, Na, Mg, S, Zn, Sr, Se, Cd, and Co content in different investigated mineral groups. Moreover, Mann-Whitney test differentiates Ca, Na, Zn, Sr, Co, and Ni between minerals in oxalate and uric acid stones. This study shows that urinary stone can provide complementary information on human exposure to elements and estimate the environmental risks involved in urinary stones formation.

  18. PRELIMINARY INVESTIGATION OF PASTA EXTRUSION PROCESS: RHEOLOGICAL CHARACTERIZATION OF SEMOLINA DOUGH

    Directory of Open Access Journals (Sweden)

    Angelo Fabbri

    2007-06-01

    Full Text Available Rheological measurements were conducted on semolina doughs. Two doughs were considered, one directly taken from an extrusion plant and another mixed in lab conditions. A rotational viscometer was used in the plate-plate configuration. Creep tests were carried on too, to verify the possibility to neglect the elastic component of strain. It was investigated the influence of the temperature on the viscous behaviour of both doughs, while only on the lab mixed dough was tested the influence of moisture content. The aim of this research is the determination of a rheological model useful for a subsequent CFD analysis of the extrusion process.

  19. Bitumen/Water Emulsions as Fuels for High-Speed Ci Engines Preliminary Investigations

    DEFF Research Database (Denmark)

    Schramm, Jesper; Sigvardsen, R.; Forman, M.

    2003-01-01

    Mixtures of bitumen and water, are cheap fuel alternatives for combustion engines. There are, however, several problems that have to be solved before these fuels can be applied in high-speed diesel engines. These are: - emulsion break up due to high temperature or high shear stress in the injection...... system - high content of heavy metals - high emissions of particulate matter and PAH This investigation deals with the problem of separation due to high shear stress in the injection system. It is shown that the viscosity of the injected fuel can be used to estimate whether the emulsion has separated...

  20. Preliminary investigations of equilibrium reconstruction quality during ELMy and ELM-free phases on JET

    Energy Technology Data Exchange (ETDEWEB)

    Gelfusa, M., E-mail: gelfusa@ing.uniroma2.it [Associazione EURATOM-ENEA—University of Rome “Tor Vergata”, Rome (Italy); Murari, A. [Associazione EURATOM-ENEA per la Fusione, Consorzio RFX, 4-35127 Padova (Italy); Peluso, E. [Associazione EURATOM-ENEA sulla Fusione, ENEA C.R. Frascati, C.P. 65, I-00044 Frascati, Rome (Italy); Gaudio, P. [Associazione EURATOM-ENEA—University of Rome “Tor Vergata”, Rome (Italy); Orsitto, F.P. [Associazione EURATOM-ENEA sulla Fusione, ENEA C.R. Frascati, C.P. 65, I-00044 Frascati, Rome (Italy); Gerasimov, S. [EURATOM/CCFE Fusion Association, Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom); Collaboration: JET-EFDA Contributors

    2013-08-21

    On JET, the magnetic topology is normally derived from the code EFIT, which solves the Grad–Shafranov equation with constraints imposed by the available measurements, typically the pick-up coils. Both the code and the measurements are expected to perform worse during ELMs. To assess this hypothesis, various statistical indicators, based on the values of the residuals and their probability distribution, have been calculated. They all show that the quality of EFIT reconstructions is clearly better in absence of ELMs. How the responsibility, for the lower quality of the reconstructions, is shared between the measurements and EFIT is a subject under investigation. © 2001 Elsevier Science. All rights reserved.

  1. Preliminary Investigation of Surface Treatments to Enhance the Wear Resistance of 60-Nitinol

    Science.gov (United States)

    Stanford, Malcolm K.

    2016-01-01

    The use of protective surface treatments on 60-Nitinol (60wt%Ni-40wt%Ti) was studied. Various nitriding techniques as well as a (Ti, Al)N coating were evaluated visually, microscopically, and by hardness and scratch testing. The chemical composition of the surface treatments was investigated by x-ray techniques. The results indicate that very hard (greater than 1,000 HK) and adherent surface layers can be produced on 60-Nitinol. Further work is needed to determine the tribological properties of these surface treatments in relevant operating environments.

  2. Investigation of the clinical features and therapeutic methods for the ...

    African Journals Online (AJOL)

    The clinical effects of the various therapeutic strategies were documented. . Results: ... drops were used for acute inflammation, while chronic inflammation was treated with antibiotic eye drops ... out in accordance with the Guidelines of the.

  3. A fluid collection system for dermal wounds in clinical investigations.

    Science.gov (United States)

    Klopfer, Michael; Banyard, Derek; Li, G-P; Widgerow, Alan; Bachman, Mark

    2016-03-01

    In this work, we demonstrate the use of a thin, self adherent, and clinically durable patch device that can collect fluid from a wound site for analysis. This device is manufactured from laminated silicone layers using a novel all-silicone double-molding process. In vitro studies for flow and delivery were followed by a clinical demonstration for exudate collection efficiency from a clinically presented partial thickness burn. The demonstrated utility of this device lends itself for use as a research implement used to clinically sample wound exudate for analysis. This device can serve as a platform for future integration of wearable technology into wound monitoring and care. The demonstrated fabrication method can be used for devices requiring thin membrane construction.

  4. Preliminary investigation on presence of peste des petits ruminants in Dakawa, Mvomero district, Morogoro region, Tanzania

    Directory of Open Access Journals (Sweden)

    Tebogo Kgotlele

    2014-04-01

    Full Text Available Peste des petits ruminants (PPR is an acute viral disease of small ruminants characterised by the sudden onset of depression, fever, oculonasal discharges, sores in the mouth, foul-smelling diarrhoea and death. For many years, in Africa, the disease was mainly confined to West and Central Africa but it has now spread southwards to previously PPR-free countries including Tanzania, Democratic Republic of Congo and Angola. The disease was first reported in Tanzania in 2008 when it was confined to the Northern Zone districts bordering Kenya. Presence of the disease has also been confirmed in southern Tanzania especially Mtwara region. Recently, a suspected outbreak of PPR in Dakawa area, Mvomero district, Morogoro region was reported. Clinical samples (lungs, intestines, lymph nodes, whole blood and sera from suspected goats (n = 8 and sheep (n = 1 were submitted to Sokoine University of Agriculture for analysis. Molecular diagnosis by amplification of the nucleoprotein gene and the fusion gene of PPR virus (PPRV using PPRV specific primers was done. Five goats and the sheep were positive for PPRV after performing RT-PCR. To our knowledge, this is the first report confirming the presence of PPR in the Mvomero district of the Morogoro region, Tanzania. Hence, more efforts should be put in place to prevent the spread of PPR in Tanzania.

  5. Parent-Child Interaction Therapy for sexual concerns of maltreated children: A preliminary investigation.

    Science.gov (United States)

    Allen, Brian; Timmer, Susan G; Urquiza, Anthony J

    2016-06-01

    The current study examines whether an evidence-based treatment for externalizing behavior problems may reduce sexual concerns among children with maltreatment histories. An archival analysis identified 44 children between the ages of 3 and 8 exhibiting externalizing problems and co-morbid sexual concerns who were treated using Parent-Child Interaction Therapy (PCIT). A second group of children receiving PCIT for externalizing behaviors without sexual concerns was included for comparison purposes (n=143). Wilcoxon Signed-Ranks Tests indicated significant improvement among the group with sexual concerns, with 63.6% of children no longer displaying clinically significant sexual concerns at post-treatment. In addition, these children showed a decline in general externalizing problems comparable to that observed among the group of children receiving PCIT and not displaying sexual concerns. Lastly, logistic regression analyses showed that pre-treatment posttraumatic stress scores did not moderate improvement of sexual concerns, suggesting that posttraumatic stress-related sexual concerns may improve from PCIT treatment. These findings suggest that evidence-based parent training interventions, specifically PCIT, may successfully reduce sexual concerns among children who experienced maltreatment. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. Preliminary safety evaluation for the Laxemar subarea. Based on data and site descriptions after the initial site investigation stage

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, Johan [JA Streamflow AB, Aelvsjoe (Sweden)

    2006-03-15

    The main objectives of this Preliminary Safety Evaluation (PSE) of the Laxemar subarea have been to determine, with limited efforts, whether the feasibility study's judgement of the suitability of the candidate area with respect to long-term safety holds up in the light of the actual site investigation data; to provide feedback to continued site investigations and site-specific repository design and to identify site-specific scenarios and geoscientific issues for further analyses. The PSE focuses on comparing the attained knowledge of the sites with the suitability criteria as set out by SKB in 2000. These criteria both concern properties of the site judged to be necessary for safety and engineering (requirements) and properties judged to be beneficial (preferences). The findings are then evaluated in order to provide feedback to continued investigations and design work. The PSE does not aim at comparing sites and does not assess compliance with safety and radiation protection criteria. The latter is eventually done in coming Safety Assessments. This preliminary safety evaluation shows that, according to existing data, the Laxemar subarea meets all safety requirements. The evaluation also shows that the Laxemar subarea meets most of the safety preferences, but for some aspects of the site description further reduction of the uncertainties would enhance the safety case. Despite the stated concerns, there is no reason, from a safety point of view, not to continue the Site Investigations at the Laxemar subarea. There are uncertainties to resolve and the safety would eventually need to be verified through a proper safety assessment. Only some of the uncertainties noted in the Site Descriptive Model have safety implications and need further resolution for this reason. Furthermore, uncertainties may need resolving for other reasons, such as giving an adequate assurance of site understanding or assisting in optimising design. Notably, there are questions about the

  7. Carboxymethyl guar gum nanoparticles for drug delivery applications: Preparation and preliminary in-vitro investigations

    Energy Technology Data Exchange (ETDEWEB)

    Dodi, G., E-mail: gianina.dodi@yahoo.co.uk [“Gheorghe Asachi” Technical University of Iasi (Romania); SCIENT — Research Centre for Instrumental Analysis, Bucharest (Romania); Pala, A. [University of Sassari, Sassari (Italy); Barbu, E. [University of Portsmouth, Portsmouth (United Kingdom); Peptanariu, D. [“Petru Poni” Institute of Macromolecular Chemistry, Iasi (Romania); Hritcu, D.; Popa, M.I. [“Gheorghe Asachi” Technical University of Iasi (Romania); Tamba, B.I. [“Gr. T. Popa” University of Medicine and Pharmacy, Iasi (Romania)

    2016-06-01

    Carboxymethyl guar gum (CMGG) synthesized from commercially available polysaccharide was formulated into nanoparticles via ionic gelation using trisodium trimetaphosphate (STMP) as cross-linking agent. Characterisation using a range of analytical techniques (FTIR, NMR, GPC, TGA and DLS) confirmed the CMGG structure and revealed the effect of the CMGG and STMP concentration on the main characteristics of the obtained nanoformulations. The average nanoparticle diameter was found to be around 208 nm, as determined by dynamic light scattering (DLS) and confirmed by scanning electron microscopy (SEM) and nanoparticle tracking analysis (NTA). Experiments using simulated gastric and intestinal fluids evidenced significant pH-dependent drug release behaviour of the nanoformulations loaded with Rhodamine B (RhB) as a model drug (loading capacity in excess of 83%), as monitored by UV–Vis. While dose-dependent cytotoxicity was observed, the nanoformulations appeared completely non-toxic at concentrations below 0.3 mg/mL. Results obtained so far suggest that carboxymethylated guar gum nanoparticles formulated with STMP warrant further investigations as polysaccharide based biocompatible drug nanocarriers. - Highlights: • Carboxymethyl guar gum nanoparticles preparation by ionic gelation • The optimum synthesis system designed particles around 200 nm • The nanoformulations appeared completely non-toxic at specific concentrations • The loaded formulations evidenced significant pH-dependent drug release behaviour • The results encourage further investigations as polysaccharidic drug nanocarriers.

  8. A preliminary investigation of the effect of force variation for myoelectric control of hand prosthesis.

    Science.gov (United States)

    Al-Timemy, Ali H; Bugmann, Guido; Escudero, Javier; Outram, Nicholas

    2013-01-01

    The myoelectric control of prostheses has been an important area of research for the past 40 years. Significant advances have been achieved with Pattern Recognition (PR) systems regarding the number of movements to be classified with high accuracy. However, practical robustness still needs further research. This paper focuses on investigating the effect of the change in force levels by transradial amputee persons on the performance of PR systems. Two below-elbow amputee persons participated in the study. Three levels of forces (low, medium, and high) were recorded for different hand grips with the help of visual feedback from the Electromyography (EMG) signals. Results showed that changing the force level degraded the performance of the myoelectric control system by up to 60% with 12 EMG channels for 4 hand grips and a rest position. We investigated different EMG feature sets in combination with a Linear Discriminant Analysis (LDA) classifier. The performance was slightly better with Time Domain (TD) features compared to Auto Regression (AR) coefficients and Root Mean Square (RMS) features. Finally, the error of the classification was considerably reduced to approximately 17% when the PR system was trained with all force levels.

  9. A preliminary investigation into the prevalence and prediction of problematic cell phone use.

    Science.gov (United States)

    Smetaniuk, Peter

    2014-03-01

    Likening mobile phone use dependency to the classification of excessive behaviors may be necessarily equivalent in seriousness to previously established addictions such as problematic computing or excessive gambling. The aim of the study explores into the behavior of excessive use of mobile phones as a pathological behavior. Two studies investigated criteria for problematic mobile phone usage by examining student (Study 1, N = 301) and nonstudent (Study 2, N = 362) responses to a set of adapted mobile phone addiction inventories. Study 1 investigated cell phone addiction inventories as constructs designed to measure problematic cell phone use. Additionally, Study 2 sought to predict age, depression, extraversion, emotional stability, impulse control, and self-esteem as independent variables that augment respondents' perceptions of problematic use. The results from Study 1 and Study 2 indicate that 10 to 25% of the participants tested exhibited problematic cell phone usage. Additionally, age, depression, extraversion, and low impulse control are the most suitable predictors for problematic use. The results of the two studies indicate that problematic mobile phone use does occur and ought to be taken seriously by the psychological community. Presently, there is limited data providing conclusive evidence for a comprehensible categorization of cell phone addiction, as well as a unified explanatory model specific to problematic mobile phone use. Studies such as this one may contribute substantial findings, adding scientific significance, and offering a valuable submission for the ongoing progress of creating intervention frameworks relative to "virtual addictions".

  10. Preliminary study to investigate the Delboeuf illusion in ring-tailed lemurs (Lemur catta: Methodological Challenges.

    Directory of Open Access Journals (Sweden)

    Maria Santacà

    2017-08-01

    Full Text Available Visual illusions are commonly used in animal cognition studies to compare visual perception among vertebrates. To date, researchers have focused their attention mainly on birds and mammals, especially apes and monkeys, but no study has investigated sensitivity to visual illusions in prosimians. Here we investigated whether lemurs (Lemur catta perceive the Delboeuf illusion, a well-known illusion that occurs when subjects misperceive the relative size of an item because of its surrounding context. In particular, we adopted the spontaneous preference paradigm used in chimpanzees and observed lemurs’ ability to select the larger amount of food. In control trials, we presented two different amounts of food on two identical plates. In test trials, we presented equal food portion sizes on two plates differing in size: If lemurs were sensitive to the illusion, they were expected to select the food portion presented on the smaller plate. In control trials, they exhibited poor performance compared to other mammals previously observed, being able to discriminate between the two quantities only in the presence of a 0.47 ratio. This result prevented us from drawing any conclusion regarding the subjects’ susceptibility to the Delboeuf illusion. In test trials with the illusory pattern, however, the subjects’ choices did not differ from chance. Our data suggest that the present paradigm is not optimal for testing the perception of the Delboeuf illusion in lemurs and highlight the importance of using different methodological approaches to assess the perceptual mechanisms underlying size discrimination among vertebrates.

  11. Chemical analysis of the elements in UZrNb alloy at CDTN: preliminary investigation

    Energy Technology Data Exchange (ETDEWEB)

    Ferraz, Wilmar Barbosa; Palmieri, Helena Eugenia L.; Reis, Sergio Carneiro dos; Santos, Ana Maria Matildes dos; Souza, Adalberto Leles de, E-mail: ferrazw@cdtn.br, E-mail: help@cdtn.br, E-mail: reissc@cdtn.br, E-mail: amms@cdtn.br, E-mail: adalbertoleles@yahoo.com.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2012-07-01

    The complete determination of major, minor, and impurity element contents in nuclear fuel is essential for quality assurance in the production of nuclear fuels. The control over all the stages of the development of nuclear fuel involves a combination of different analytical methods such as spectrometric methods. The goal of our investigation is to develop and evaluate procedures for the determination of main elements and carbon impurity present in some uranium alloys. In this paper the element contents in U2.5Zr7.5Nb, U3Zr9Nb alloys and U6Nb, in weight percent, were investigated by means of scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM/EDS), inductively coupled plasma mass spectrometry (ICP-MS), wavelength dispersive fluorescence spectrometry (XRF/WDS) and energy-dispersive X-ray spectroscopy (EDX). The total carbon was determined using a carbon analyzer in which the sample is oxidized to carbon dioxide (IR absorption). It was observed a satisfactory correlation between the results obtained by employed methods. (author)

  12. Preliminary investigation to estimate soil NAPL retention using parametric pedotransfer functions

    Science.gov (United States)

    Hernádi, Hilda; Makó, András

    2014-10-01

    Organic liquid retention of soils is a primary input variable for modelling the nonaqueous phase liquid transport and behaviour in the subsurface. In environmental and soil physical practice, it is mainly determined by scaling based on the water retention of soils or with charts of average empirical values of organic liquid retention or the fitting parameters of hydraulic functions. Predicting the fitting parameters of organic liquid retention curves with pedotransfer functions might be a promising alternative method, but this topic has only been researched to a limited extent. Thus we investigated the applicability of different hydraulic functions (3- and 4- parameter form of the van Genuchten equation and Brutsaert equation) for fitting organic liquid retention characteristics. Multivariate linear regression was used to build and develop pedotransfer functions, modelling relations between original and transformed values of basic soil properties and organic liquid retention. We attempted to generate parametric pedotransfer functions. According to our results, the applicability of hydraulic functions for fitting nonaqueous phase liquid retention curves to the experimental data was proven. The investigations gave promising results for the possibility to estimate soil nonaqueous phase liquid retention with parametric pedotransfer functions.

  13. A preliminary investigation of cell growth after irradiation using a modulated x-ray intensity pattern

    Energy Technology Data Exchange (ETDEWEB)

    Bromley, Regina [Northern Sydney Cancer Centre, Radiation Oncology, Royal North Shore Hospital, Sydney, NSW 2065 (Australia); Davey, Ross [Institute of Medical Physics, School of Physics, Sydney University, NSW 2006 (Australia); Oliver, Lyn [Northern Sydney Cancer Centre, Radiation Oncology, Royal North Shore Hospital, Sydney, NSW 2065 (Australia); Harvie, Rozelle [Institute of Medical Physics, School of Physics, Sydney University, NSW 2006 (Australia); Baldock, Clive [Bill Walsh Cancer Research Laboratories, Department of Medical Oncology, Royal North Shore Hospital, Sydney, NSW 2065 (Australia)

    2006-08-07

    In this study we have investigated a spatial distribution of cell growth after their irradiation using a modulated x-ray intensity pattern. An A549 human non-small cell lung cancer cell line was grown in a 6-well culture. Two of the wells were the unirradiated control wells, whilst another two wells were irradiated with a modulated x-ray intensity pattern and the third two wells were uniformly irradiated. A number of plates were incubated for various times after irradiation and stained with crystal violet. The spatial distribution of the stained cells within each well was determined by measurement of the crystal violet optical density at multiple positions in the plate using a microplate photospectrometer. The crystal violet optical density for a range of cell densities was measured for the unirradiated well and this correlated with cell viability as determined by the MTT cell viability assay. An exponential dose response curve was measured for A549 cells from the average crystal violet optical density in the uniformly irradiated well up to a dose of 30 Gy. By measuring the crystal violet optical density distribution within a well the spatial distribution of cell growth after irradiation with a modulated x-ray intensity pattern can be plotted. This method can be used for in vitro investigation into the changes in radiation response associated with treatment using intensity modulated radiation therapy (IMRT)

  14. Environmental pollution of polybrominated diphenyl ethers from industrial plants in China: a preliminary investigation.

    Science.gov (United States)

    Deng, Chao; Chen, Yuan; Li, Jinhui; Li, Ying; Li, Huafen

    2016-04-01

    Although numerous studies have shown the presence of polybrominated diphenyl ethers (PBDEs) in various environmental media, attention to their distribution in the environmental media surrounding industrial facilities is limited. In this study, eight PBDEs congeners (BDE-28, -47, -99, -100, -153, -154, -183, -209) were investigated in surface soils and water samples collected from commercial PBDE manufacturers, flame-retardant plastic modification plants and waste electrical and electronic equipment recycling facilities in China. Analysis of target compounds was performed using the model NCI GC-MS in SIM mode. The concentrations of ∑8PBDEs varied from 193.1 to 22,004.3 ng/L in water samples and from 1209.3 to 226,906 ng/g dry wt in surface soils, respectively. More severe PBDE contamination, when compared with previously reported data, was found in industrial areas in this study. This indicates that these industrial areas are highly polluted with PBDEs. BDE-209 was the predominant congener, accounting for more than 94% in this study, except for a 68.75% portion at one site. Our results show that PBDE manufacturing and flame-retardant plastic modification plants, easily overlooked by the public, are two primary PBDE pollution sources although they affect surrounding areas. Further research is needed, aimed at managing industrial PBDE emissions and eliminating environmental PBDE pollution, to investigate the material flows and environmental fates of PBDEs in all stages of the life cycle.

  15. Proteogenomic Investigation of Strain Variation in Clinical Mycobacterium tuberculosis Isolates

    KAUST Repository

    Heunis, Tiaan

    2017-08-18

    Mycobacterium tuberculosis consists of a large number of different strains that display unique virulence characteristics. Whole-genome sequencing has revealed substantial genetic diversity among clinical M. tuberculosis isolates, and elucidating the phenotypic variation encoded by this genetic diversity will be of utmost importance to fully understand M. tuberculosis biology and pathogenicity. In this study we integrated whole-genome sequencing and mass spectrometry (GeLC-MS/MS) to reveal strain-specific characteristics in the proteomes of two clinical M. tuberculosis Latin American-Mediterranean isolates. Using this approach we identified 59 peptides containing single amino acid variants, which covered ~9% of all total coding nonsynonymous single nucleotide variants detected by whole-genome sequencing. Furthermore, we identified 29 distinct peptides that mapped to a hypothetical protein not present in the M. tuberculosis H37Rv reference proteome. Here we provide evidence for the expression of this protein in the clinical M. tuberculosis SAWC3651 isolate. The strain-specific databases enabled confirmation of genomic differences (i.e. large genomic regions of difference and nonsynonymous single nucleotide variants) in these two clinical M. tuberculosis isolates and allowed strain differentiation at the proteome level. Our results contribute to the growing field of clinical microbial proteogenomics and can improve our understanding of phenotypic variation in clinical M. tuberculosis isolates.

  16. Investigating the role of combined acoustic-visual feedback in one-dimensional synchronous brain computer interfaces, a preliminary study

    Directory of Open Access Journals (Sweden)

    Gargiulo GD

    2012-09-01

    Full Text Available Gaetano D Gargiulo,1–3 Armin Mohamed,1 Alistair L McEwan,1 Paolo Bifulco,2 Mario Cesarelli,2 Craig T Jin,1 Mariano Ruffo,2 Jonathan Tapson,3 André van Schaik31School of Electrical and Information Engineering, The University of Sydney, New South Wales, Australia; 2Dipartimento di Ingegneria Elettronica e delle Telecomunicazioni "Federico II" University of Naples, Naples, Italy; 3BENS Laboratory, MARCS Institute, The University of Western Sydney, New South Wales, AustraliaAbstract: Feedback plays an important role when learning to use a brain computer interface (BCI, particularly in the case of synchronous feedback that relies on the interaction subject. In this preliminary study, we investigate the role of combined auditory-visual feedback during synchronous µ rhythm-based BCI sessions to help the subject to remain focused on the selected imaginary task. This new combined feedback, now integrated within the general purpose BCI2000 software, has been tested on eight untrained and three trained subjects during a monodimensional left-right control task. In order to reduce the setup burden and maximize subject comfort, an electroencephalographic device suitable for dry electrodes that required no skin preparation was used. Quality and index of improvement was evaluated based on a personal self-assessment questionnaire from each subject and quantitative data based on subject performance. Results for this preliminary study show that the combined feedback was well tolerated by the subjects and improved performance in 75% of the naïve subjects compared with visual feedback alone.Keywords: brain computer interface, dry electrodes, subject feedback

  17. PRELIMINARY PLANKTON INVESTIGATIONS IN THE GRAVEL PIT AND WINTERPONDS NEAR JAGODNO

    Directory of Open Access Journals (Sweden)

    Marija Tomec

    2007-04-01

    Full Text Available Investigations of plankton populations have been performed in the gravel pit and two winterponds near the place Jagodno, Novo Čiće, in the vicinity of Velika Gorica. Our goal was to examine plankton composition of the gravel pit and winterponds, two ecosystems characterized by specific life–conditions which change with time and space. Investigations were conducted during June 2007. Plankton samples were collected from water surface layer at four locations (two locations in the gravel pit and one location in each of two winterponds. Along with plankton sample collecting, measurements were made of some physico–chemical parameters (water temperature, pH–values and dissolved oxygen content in water. Water temperature at two sampling locations in the gravel pit and one location at each of the winterponds depended on the surrounding air temperature, and ranged from 22.5ºC to 23.6ºC. pH–reaction was alkaline, ranging from 8. 23 to 9. 02. Dissolved oxygen content in the gravel pit was around 10 mg/O2; in winterponds it ranged from 7.6 to 9.7 mg/O2 (Table 1. At the gravel pit locations total number of 32 phytoplankton species were determined; in winterponds were determined 37 (microphytic species? while zooplankton was represented in the phytoplankton community composition at the four locations with 5 species. Phytoplankton species determined in the samples from two gravel pit locations belonged to the system groups Dinophyta, Chrysophyta and Chlorophyta while in the samples from winterpond locations, along with the mentioned system groups, were found as well the representatives from the groups Cyanophyta/Cyanobacteria and Euglenophyta. Zooplankton species belonged to the groups Rotatoria, Cladocera and Copepoda (Table 2. In gravel pit locations dominated diatoms or Bacillarophyceae while in winterponds the majority of phytoplankton mass consisted of the representatives of the species Cyanophyta/Cyanobacteria and Euglenophyta. Qualitative

  18. Investigation of keratinophilic fungi from soils in western Australia a preliminary survey.

    Science.gov (United States)

    McAleer, R

    1980-11-28

    In order to determine which species of geophilic dermatophytes were present in Western Australian soils 299 samples were investigated. These samples were collected from a range of locations, 208 towns throughout the state and 91 samples from the Perth Metropolitan area. Most samples were collected from areas frequented by people and animals, such as home gardens, parks and animal yards. Of the total 299 soils, 271 (90.6%) yielded keratinophilic fungi. A total of 181 dermatophytes were isolated, and there were 205 isolations of other keratinophilic fungi. Microsporum gypseum (30.7%) was the most prevalent dermatophyte recovered from soil followed by Microsporum cookei (21.7%) and then Trichophyton ajelloi (8.0%). No other dermatophytes were recovered. Chrysosporium indicum was the most common of all the keratinophilic fungi and was isolated from 50.1% of the samples. Mixed growth was obtained from 33.5% of the soil samples.

  19. The Coffee Berry Borer (Hypothenemus hampei) Invades Hawaii: Preliminary Investigations on Trap Response and Alternate Hosts.

    Science.gov (United States)

    Messing, Russell H

    2012-07-11

    In August 2010 the coffee berry borer, Hypothenemus hampei, was first reported to have invaded the Kona coffee growing region of Hawaii, posing a severe economic challenge to the fourth largest agricultural commodity in the State. Despite its long and widespread occurrence throughout the tropics as the most serious pest of coffee, there are still discrepancies in the literature regarding several basic aspects of berry borer biology relevant to its control. In Kona coffee plantations, we investigated the beetles' response to several trap and lure formulations, and examined the occurrence of beetles in seeds of alternate host plants occurring adjacent to coffee farms. While traps were shown to capture significant numbers of beetles per day, and the occurrence of beetles in alternate hosts was quite rare, the unique situation of coffee culture in Hawaii will make this pest extremely challenging to manage in the Islands.

  20. Preliminary phytochemical investigation of pod and seed extract ofCrotalaria incana L. subsp. purpurscens

    Institute of Scientific and Technical Information of China (English)

    Mathewos Anza; Habtamu Gelaw

    2015-01-01

    Objective:To investigate various phytochemical constituents present in pod and seed of Crotalaria incanaL. (C. incana). Methods:A number of phytochemical tests were applied to identify the class of compounds in the CH2Cl2/CH3OH (1:1) pod and seed extract ofC. incana. Results: Phytochemical screening of the CH2Cl2/CH3OH (1:1) pod and seed extract ofC. incanasubsp.purpurscens revealed that the presence of alkaloids, flavonoids, terpenoids, tannins and stroids. Conclusions: The present work conducted on the CH2Cl2:CH3OH (1:1) pod and seed extract of C. incana identified various classes of compounds present on the pod and seed extract.

  1. Does athletic training in volleyball modulate the components of visual evoked potentials? A preliminary investigation.

    Science.gov (United States)

    Zwierko, Teresa; Lubiński, Wojciech; Lesiakowski, Piotr; Steciuk, Hanna; Piasecki, Leszek; Krzepota, Justyna

    2014-01-01

    This longitudinal study investigated visual evoked potentials (VEPs) in 11 young female volleyball players who participated in extensive training for 2 years. The control group consisted of 7 age-matched female students who were not involved in any regular sports activity. Recordings of VEPs were performed twice: baseline recording (i.e., before training began) and after 2 years of systematic, volleyball-specific athletic training. The effect of athletic training on visual signal conductivity was assessed by recording the latency of N75, P100 and N135 components of the VEPs waveform. Extensive experience with volleyball training reduced signal conductivity time through visual pathway. Specifically, the latency of P100 was reduced on average by 2.2 ms during binocular viewing. Moreover, athletes had reduced N75 latency (difference of 3.3 ms) for visual stimuli that generated greater response from peripheral retina. These results indicate that sport training can affect very early sensory processing in athletes.

  2. Precise femtosecond laser ablation of dental hard tissue: preliminary investigation on adequate laser parameters

    Science.gov (United States)

    Hikov, Todor; Pecheva, Emilia; Montgomery, Paul; Antoni, Frederic; Leong-Hoi, Audrey; Petrov, Todor

    2017-01-01

    This work aims at evaluating the possibility of introducing state-of-the-art commercial femtosecond laser system in restorative dentistry by maintaining well-known benefits of lasers for caries removal, but also in overcoming disadvantages such as thermal damage of irradiated substrate. Femtosecond ablation of dental hard tissue is investigated by changing the irradiation parameters (pulsed laser energy, scanning speed and pulse repetition rate), assessed for enamel and dentin. The femtosecond laser system used in this work may be suitable for cavity preparation in dentin and enamel, due to the expected effective ablation and low temperature increase when using ultra short laser pulses. If adequate laser parameters are selected, this system seems to be promising for promoting a laser-assisted, minimally invasive approach in restorative dentistry.

  3. Preliminary Investigation of Candidate Materials for Use in Accident Resistant Fuel

    Energy Technology Data Exchange (ETDEWEB)

    Jason M. Harp; Paul A. Lessing; Blair H. Park; Jakeob Maupin

    2013-09-01

    As part of a Collaborative Research and Development Agreement (CRADA) with industry, Idaho National Laboratory (INL) is investigating several options for accident resistant uranium compounds including silicides, and nitrides for use in future light water reactor (LWR) fuels. This work is part of a larger effort to create accident tolerant fuel forms where changes to the fuel pellets, cladding, and cladding treatment are considered. The goal fuel form should have a resistance to water corrosion comparable to UO2, have an equal to or larger thermal conductivity than uranium dioxide, a melting temperature that allows the material to stay solid under power reactor conditions, and a uranium loading that maintains or improves current LWR power densities. During the course of this research, fuel fabricated at INL will be characterized, irradiated at the INL Advanced Test Reactor, and examined after irradiation at INL facilities to help inform industrial partners on candidate technologies.

  4. Effect of Reinforcement on Early-Age Concrete Temperature Stress: Preliminary Experimental Investigation and Analytical Simulation

    Directory of Open Access Journals (Sweden)

    Jianda Xin

    2015-01-01

    Full Text Available For concrete under short-term loading, effect of reinforcement on concrete crack resistance capability is usually negligible; however, recent research results show that extension of this viewpoint to concrete under long-term loading (temperature variation may be unsuitable. In order to investigate this phenomenon, this paper presents the experimental and analytical results of early-age reinforced concrete temperature stress development under uniaxial restraint. The experiments were carried out on a temperature stress testing machine (TSTM. Experimental results show that the coupling of reinforcement and concrete creep behavior influenced the concrete temperature stress development, and nearly 16% of concrete stress was reduced in the current research. Moreover, the cracking time of reinforced concrete was also delayed. Finally, based on the principle of superposition, analytical simulations of effect of reinforcement on concrete temperature stress have been performed.

  5. Sexual orientation and the sleep-wake cycle: a preliminary investigation.

    Science.gov (United States)

    Rahman, Q; Silber, K

    2000-04-01

    The sleep-wake cycle as a function of sexual orientation was investigated. Male and female, heterosexual and homosexual subjects completed a sexual-orientation questionnaire and four sets of recording sheets of activities for a 16-day period. Mean sleep duration was calculated from the record sheets using waking-up and going-to-sleep times. It was predicted that homosexual males and females would awake earlier, go to sleep later, and thus have shorter sleep duration compared to heterosexuals. This was supported by the results. Although a sexual orientation by sex interaction just failed to reach significance, additional analyses of the results indicated that differences in sleep duration between heterosexuals and homosexuals were markedly related to sex. The possibility that these results reflect dimorphic features of the human supra-chiasmatic nucleus (SCN) is discussed.

  6. A preliminary investigation into the moral reasoning abilities of UK veterinarians.

    Science.gov (United States)

    Batchelor, C E M; Creed, A; McKeegan, D E F

    2015-08-01

    Veterinary medicine is an ethically challenging profession, but the ethical reasoning abilities of practising veterinarians in the UK have never been formally assessed. This study investigated moral reasoning ability in 65 qualified veterinarians (38 practising and 27 academic) and 33 members of the public in the UK using the Defining Issues Test. Academic veterinarians had higher scores than members of the public but practising veterinarians did not. There was large variation in moral reasoning abilities among qualified veterinarians. Moral reasoning score in veterinarians did not improve with years of experience. These results show that despite having a professional degree moral reasoning skills of practising veterinarians may be insufficient to deal with the demands of their profession. This could have implications for animal welfare, client services and veterinarian wellbeing. The results highlight the need for more training in this area. British Veterinary Association.

  7. The relation of narcissism and self-esteem to conduct problems in children: a preliminary investigation.

    Science.gov (United States)

    Barry, Christopher T; Frick, Paul J; Killian, Amber L

    2003-03-01

    Investigated several possible models to explain the seemingly discrepant relations between self-esteem and conduct problems, as both low self-esteem and exaggerated levels of self-esteem, thought to be captured by narcissism, have been associated with aggressive and antisocial behavior. Our sample consisted of 98 nonreferred children (mean age = 11.9 years; SD = 1.68 years) recruited from public schools to oversample children at risk for severe aggressive and antisocial behavior. Results indicated that certain aspects of narcissism (i.e., those indicating a need to be evaluated well by, and obtain status over, others) were particularly predictive of maladaptive characteristics and outcomes such as low self-esteem, callous-unemotional (CU) traits, and conduct problems. In addition, the relation between narcissism and conduct problems was moderated by self-esteem level, such that children with relatively high levels of narcissism and low self-esteem showed the highest rates of conduct-problem symptoms.

  8. A preliminary investigation of materialism and impulsiveness as predictors of technological addictions among young adults.

    Science.gov (United States)

    Roberts, James A; Pirog, Stephen F

    2013-03-01

    Background and aims The primary objective of the present research is to investigate the drivers of technological addiction in college students - heavy users of Information and Communication Technology (ICT). The study places cell phone and instant messaging addiction in the broader context of consumption pathologies, investigating the influence of materialism and impulsiveness on these two technologies. Clearly, cell phones serve more than just a utilitarian purpose. Cell phones are used in public and play a vital role in the lives of young adults. The accessibility of new technologies, like cell phones, which have the advantages of portability and an ever increasing array of functions, makes their over-use increasingly likely. Methods College undergraduates (N = 191) from two U.S. universities completed a paper and pencil survey instrument during class. The questionnaire took approximately 15-20 minutes to complete and contained scales that measured materialism, impulsiveness, and mobile phone and instant messaging addiction. Results Factor analysis supported the discriminant validity of Ehrenberg, Juckes, White and Walsh's (2008) Mobile Phone and Instant Messaging Addictive Tendencies Scale. The path model indicates that both materialism and impulsiveness impact the two addictive tendencies, and that materialism's direct impact on these addictions has a noticeably larger effect on cell phone use than instant messaging. Conclusions The present study finds that materialism and impulsiveness drive both a dependence on cell phones and instant messaging. As Griffiths (2012) rightly warns, however, researchers must be aware that one's addiction may not simply be to the cell phone, but to a particular activity or function of the cell phone. The emergence of multi-function smart phones requires that research must dig beneath the technology being used to the activities that draw the user to the particular technology.

  9. Trace evidence characteristics of DNA: A preliminary investigation of the persistence of DNA at crime scenes.

    Science.gov (United States)

    Raymond, Jennifer J; van Oorschot, Roland A H; Gunn, Peter R; Walsh, Simon J; Roux, Claude

    2009-12-01

    The successful recovery of trace or contact DNA is highly variable. It is seemingly dependent on a wide range of factors, from the characteristics of the donor, substrate and environment, to the delay between contact and recovery. There is limited research on the extent of the effect these factors have on trace DNA analysis. This study investigated the persistence of trace DNA on surfaces relevant to the investigation of burglary and robbery offences. The study aimed to limit the number of variables involved to solely determine the effect of time on DNA recovery. Given that it is difficult to control the quantity of DNA deposited during a hand contact, human buffy coat and DNA control solution were chosen as an alternative to give a more accurate measure of quantity. Set volumes of these solutions were deposited onto outdoor surfaces (window frames and vinyl material to mimic burglary and 'bag snatch' offences) and sterile glass slides stored in a closed environment in the laboratory, for use as a control. Trace DNA casework data was also scrutinised to assess the effect of time on DNA recovery from real samples. The amount of DNA recovered from buffy coat on the outdoor surfaces declined by approximately half over two weeks, to a negligible amount after six weeks. Profiles could not be obtained after two weeks. The samples stored in the laboratory were more robust, and full profiles were obtained after six weeks, the longest time period tested in these experiments. It is possible that profiles may be obtained from older samples when kept in similarly favourable conditions. The experimental results demonstrate that the ability to recover DNA from human cells on outdoor surfaces decreases significantly over two weeks. Conversely, no clear trends were identified in the casework data, indicating that many other factors are involved affecting the recovery of trace DNA. Nevertheless, to ensure that valuable trace evidence is not lost, it is recommended that crime scenes

  10. Nutritional status and nutritional habits of men with benign prostatic hyperplasia or prostate cancer - preliminary investigation.

    Science.gov (United States)

    Goluch-Koniuszy, Zuzanna; Rygielska, Magda; Nowacka, Ilona

    2013-01-01

    The ageing in men, the most frequent pathologic lesions affecting the prostatic gland in this period are benign prostatic hyperplasia (BPH) and prostate cancer (PC), the course of which may be influenced by the improper nutritional status of patients and their nutritional habits. The aim of this study was, therefore, to evaluate the nutritional status and eating habits of men diagnosed and treated for one of the above diseases. MATERIAL AND METODS: The nutritional status of 30 male patients with clinically confirmed and treated disease of the prostatic gland, including 15 men (aged 51-75 years) with BPH and 15 men (aged 51-73 years) with PC, was evaluated based on their BMI, WC, WHR, and WHtR parameters. In turn, the energy and nutritive value of 90 daily food rations (DFRs) was evaluated. Finally, calculations were made for the Key's index of diet atherogenicity, resultant Glycemic Index (GI) and Glycemic Load (GL). Higher values of the BMI, WC, WHR and WHtR parameters were noted in the men with PC, they were also characterized by a higher incidence of peripheral subcutaneous obesity and visceral obesity. The DFRs of the men were characterized by a low energy value and by a low intake of available carbohydrates, dietary fi ber, K, Ca, Mg, vitamins D and C, and fl uids at a simultaneously high intake of total and animal protein, cholesterol, Na, P, Fe, Cu as well as vitamins B2 and PP. The contribution of energy derived from the basic nutrients diverged from the recommended values. In addition, the DFRs were characterized by high values of Key's index and 24-h GL. Differences in meeting the RDA for selected nutrients between the analysed groups of men were statistically significant. The improper nutritional status of the men may result from their incorrect nutritional habits which fail to improve their health status, and even predispose them to the development of some diet-dependent diseases. In view of that, both correction of diets of the surveyed men, as well as

  11. Nutritional status and nutritional habits of men with benign prostatic hyperplasia or prostate cancer - preliminary investigation

    Directory of Open Access Journals (Sweden)

    Zuzanna Goluch-Koniuszy

    2013-09-01

    Full Text Available Introduction. The ageing in men, the most frequent pathologic lesions affecting the prostatic gland in this period are benign prostatic hyperplasia (BPH and prostate cancer (PC, the course of which may be infl uenced by the improper nutritional status of patients and their nutritional habits. The aim of this study was, therefore, to evaluate the nutritional status and eating habits of men diagnosed and treated for one of the above diseases. Material and metods. The nutritional status of 30 male patients with clinically confi rmed and treated disease of the prostatic gland, including 15 men (aged 51-75 years with BPH and 15 men (aged 51-73 years with PC, was evaluated based on their BMI, WC, WHR, and WHtR parameters. In turn, the energy and nutritive value of 90 daily food rations (DFRs was evaluated. Finally, calculations were made for the Key’s index of diet atherogenicity, resultant Glycemic Index (GI and Glycemic Load (GL. Results. Higher values of the BMI, WC, WHR and WHtR parameters were noted in the men with PC, they were also characterized by a higher incidence of peripheral subcutaneous obesity and visceral obesity. The DFRs of the men were characterized by a low energy value and by a low intake of available carbohydrates, dietary fi ber, K, Ca, Mg, vitamins D and C, and fl uids at a simultaneously high intake of total and animal protein, cholesterol, Na, P, Fe, Cu as well as vitamins B2 and PP. The contribution of energy derived from the basic nutrients diverged from the recommended values. In addition, the DFRs were characterized by high values of Key’s index and 24-h GL. Differences in meeting the RDA for selected nutrients between the analysed groups of men were statistically signifi cant. Conclusions. The improper nutritional status of the men may result from their incorrect nutritional habits which fail to improve their health status, and even predispose them to the development of some diet-dependent diseases. In view of that

  12. Blood pressure and heart rate during ovariohysterectomy in pyometra and control dogs: a preliminary investigation.

    Science.gov (United States)

    Höglund, Odd Viking; Lövebrant, Johanna; Olsson, Ulf; Höglund, Katja

    2016-11-17

    Surgery causes a stress response, a physiologic response to trauma. The intraoperative surgical stress response in dogs diagnosed with pyometra has not previously been described. The aim of this study was to investigate the intraoperative surgical stress response, assessed by blood pressure and heart rate measurements, in dogs diagnosed with pyometra and healthy controls. All dogs were premedicated with acepromazine and methadone, anaesthesia was induced with propofol and maintained with isoflurane, where after the dogs were subjected to ovariohysterectomy. Eight dogs diagnosed with pyometra and eight healthy controls were used. Systolic blood pressure and heart rate were measured to assess the surgical stress response. Additionally propofol dosage at induction of anaesthesia and the end-tidal isoflurane concentration were investigated. The surgery was split into four phases. Phase 0 was the period 10 min before the skin incision, phase 1 was skin incision and opening of abdomen, phase 2 was manipulation of uterine horns, lifting of the ovary with stretching of the mesovarium, ligation and transection of mesovarium and phase 3 was ligation and transection of cervix, removal of organs and closing of the abdomen. Dosage of propofol at induction of anaesthesia was 3.6 ± 1 mg/kg in dogs with pyometra and 4.1 ± 1 in healthy controls (P = 0.37). In both groups, systolic blood pressure increased between phase 1 and 2, from 87 ± 15 to 114 ± 19 mmHg in dogs with pyometra, and from 88 ± 18 to 106 ± 20 mmHg in healthy controls, (both P blood pressure did not differ significantly between groups in any of the phases. Heart rate and end-tidal concentration of isoflurane did not differ significantly between phases or between groups. The increased blood pressure at removal of ovaries during ovariohysterectomy suggests a pronounced noxious stimulus at this part of the procedure. In principle, the study parameters and response to surgery did not differ

  13. Preliminary Investigation of an SOI-based Arrayed Waveguide Grating Demodulation Integration Microsystem

    Science.gov (United States)

    Li, Hongqiang; Zhou, Wenqian; Liu, Yu; Dong, Xiaye; Zhang, Cheng; Miao, Changyun; Zhang, Meiling; Li, Enbang; Tang, Chunxiao

    2014-01-01

    An arrayed waveguide grating (AWG) demodulation integration microsystem is investigated in this study. The system consists of a C-band on-chip LED, a 2 × 2 silicon nanowire-based coupler, a fiber Bragg grating (FBG) array, a 1 × 8 AWG, and a photoelectric detector array. The coupler and AWG are made from silicon-on-insulator wafers using electron beam exposure and response-coupled plasma technology. Experimental results show that the excess loss in the MMI coupler with a footprint of 6 × 100 μm2 is 0.5423 dB. The 1 × 8 AWG with a footprint of 267 × 381 μm2 and a waveguide width of 0.4 μm exhibits a central channel loss of −3.18 dB, insertion loss non-uniformity of −1.34 dB, and crosstalk level of −23.1 dB. The entire system is preliminarily tested. Wavelength measurement precision is observed to reach 0.001 nm. The wavelength sensitivity of each FBG is between 0.04 and 0.06 nm/dB. PMID:24797561

  14. A preliminary investigation of anticholinesterase activity of some Iranian medicinal plants commonly used in traditional medicine.

    Science.gov (United States)

    Jazayeri, Seyed Behzad; Amanlou, Arash; Ghanadian, Naghmeh; Pasalar, Parvin; Amanlou, Massoud

    2014-01-08

    The aim of this study was to evaluate acetylcholinesterase inhibitory activity of some commonly used herbal medicine in Iran to introduce a new source for management of Alzheimer's disease. A total of 18 aqueous-methanolic extract (1:1; v/v) from the following plants: Brassica alba, Brassica nigra, Camellia sinensis, Cinchona officinalis, Citrus aurantifolia, Citrus x aurantium, Ferula assafoetida, Humulus lupulus, Juglans regia, Juniperus sabina, Myristica fragrans, Pelargonium graveolens, Pistacia vera, Punica granatum, Rheum officinale, Rosa damascena, Salix alba, and Zizyphus vulgaris were prepared and screened for their acetylcholinesterase inhibitory activity using in vitro Ellman spectrophotometric method. According to the obtained results, the order of inhibitory activity (IC50 values, μg /ml) of extracts from highest to the lowest was: C. sinensis (5.96), C. aurantifolia (19.57), Z. vulgaris (24.37), B. nigra (84.30) and R. damascena (93.1). The results indicated and confirmed the traditional use of these herbs for management of central nervous system disorders. C. sinensis showed the highest activity in inhibition of acetylcholinesterase. However, further investigations on identification of active components in the extracts are needed.

  15. A Preliminary Investigation of the Application of Modern Crustal Deformation Data in Seismic Zonation

    Institute of Scientific and Technical Information of China (English)

    Zhou Bengang; Zhou Qing

    2006-01-01

    Using GPS observation data for the middle segment of the Fenwei seismic zone during the time period of 1996 ~ 2001, the velocity field of crustal movement is calculated. Thus, the vectors of relative horizontal movement between measuring points in the region are also obtained.Adopting a deformation model of homogeneous elastic body, the principal strain rate parameters of deformation units are calculated. A method is introduced to calculate the rate of seismic moment accumulation due to crustal deformation. The problems of using this rate to analyze the tendency of seismicity in the zone, and to estimate the recurrence interval of large earthquakes in the potential seismic source areas (PSSA) are discussed. The results show that the rate of seismic moment accumulation in the middle segment of the Fenwei zone is 4.22 × 1017 Nm/a, which is much higher than the average release rate of seismic moment in the current activity period. This means that the belt is now in a stage of seismic strain accumulation and that the seismicity would become stronger in the future than now. The results of estimation of the recurrence interval of large earthquakes in the Dingxiang and Huozhou PSSA are close to the results obtained from studying active faults. This implies that the use of the proposed estimation method is worthy of further investigation. In particular, it is of greater practical significance for those regions that have shorter history of earthquake records or lower degree of active structure study.

  16. Laser vibrometry characterisation of a microfluidic lab-on-a-chip device: a preliminary investigation

    Science.gov (United States)

    Fury, C.; Gélat, P. N.; Jones, P. H.; Memoli, G.

    2014-04-01

    Since their original inception as ultrasound contrast agents, potential applications of microbubbles have evolved to encompass molecular imaging and targeted drug delivery. As these areas develop, so does the need to understand the mechanisms behind the interaction of microbubbles both with biological tissue and with other microbubbles. There is therefore a metrological requirement to develop a controlled environment in which to study these processes. Presented here is the design and characterisation of such a system, which consists of a microfluidic chip, specifically developed for manipulating microbubbles using both optical and acoustic trapping. A laser vibrometer is used to observe the coupling of acoustic energy into the chip from a piezoelectric transducer bonded to the surface. Measurement of the velocity of surface waves on the chip is investigated as a potential method for inferring the nature of the acoustic fields excited within the liquid medium of the device. Comparison of measured surface wavelengths with wave types suggests the observation of anti-symmetric Lamb or Love-Kirchhoff waves. Further visual confirmation of the acoustic fields through bubble aggregation highlights differences between the model and experimental results in predicting the position of acoustic pressure nodes in relation to excitation frequency.

  17. Carboxymethyl guar gum nanoparticles for drug delivery applications: Preparation and preliminary in-vitro investigations.

    Science.gov (United States)

    Dodi, G; Pala, A; Barbu, E; Peptanariu, D; Hritcu, D; Popa, M I; Tamba, B I

    2016-06-01

    Carboxymethyl guar gum (CMGG) synthesized from commercially available polysaccharide was formulated into nanoparticles via ionic gelation using trisodium trimetaphosphate (STMP) as cross-linking agent. Characterisation using a range of analytical techniques (FTIR, NMR, GPC, TGA and DLS) confirmed the CMGG structure and revealed the effect of the CMGG and STMP concentration on the main characteristics of the obtained nanoformulations. The average nanoparticle diameter was found to be around 208 nm, as determined by dynamic light scattering (DLS) and confirmed by scanning electron microscopy (SEM) and nanoparticle tracking analysis (NTA). Experiments using simulated gastric and intestinal fluids evidenced significant pH-dependent drug release behaviour of the nanoformulations loaded with Rhodamine B (RhB) as a model drug (loading capacity in excess of 83%), as monitored by UV-Vis. While dose-dependent cytotoxicity was observed, the nanoformulations appeared completely non-toxic at concentrations below 0.3 mg/mL. Results obtained so far suggest that carboxymethylated guar gum nanoparticles formulated with STMP warrant further investigations as polysaccharide based biocompatible drug nanocarriers.

  18. Preliminary Numerical Investigations of Entropy Generation in Electric Machines Based on a Canonical Configuration

    Directory of Open Access Journals (Sweden)

    Toni Eger

    2015-12-01

    Full Text Available The present paper analyzes numerically the entropy generation induced by forced convection in a canonical configuration. The configuration itself includes two well known fluid dynamic problems: (1 an external flow (flow around a cylinder, Kármán flow; and (2 an internal flow (flow between two concentric rotating cylinders, Couette flow. In many daily engineering issues (e.g., cooling of electric machines, a combination of these problems occurs and has to be investigated. Using the canonical configuration, the fields of entropy generation are analyzed in this work for a constant wall heat flux but varying two key parameters (Reynolds numbers Re∞ and Re0. The entropy generation due to conduction shows an absolute minimum around Re0 = 10,000. The same minima can be found by a detailed analysis of the temperature profile. Thus, entropy generation seems to be a suitable indicator for optimizing heat exchange processes and delivers a large amount of information concerning fluid and heat transport.

  19. Changes of Substance P in the Crevicular Fluid in relation to Orthodontic Movement Preliminary Investigation

    Directory of Open Access Journals (Sweden)

    Luca Levrini

    2013-01-01

    Full Text Available Substance P (SP is a tachykinin released from both the central and the peripheral endings of primary afferent neurons and functions as a neurotransmitter. As a transmitter signaling pain, substance P is involved in nociception and is an extremely potent vasodilator. We found several studies about this neuropeptide especially in relation to parodontology and a few orthodontic reviews. This is because in the past the importance of this neuropeptide in dental element undergoing periodontal inflammation was observed. The aims of the present pilot study was to investigate whether the substance P was present in gingival crevicular fluid in dental elements undergoing orthodontic treatment with Invisalign technique compared to teeth belonging to the same series but not undergoing orthodontic movement. We analysed gengival crevicular fluid (GCF collected from four young subjects, using a paper cone for a time of 60 seconds. The results showed that SP is present in the gengival sulcus in elements undergoing orthodontic forces during treatment with Invisalign technique and not in the control teeth. During the literature analysis, we have found a lot of papers describing involvement of SP in periodontitis and inflammatory diseases, but further studies are needed in order to demonstrate the role of this neuropeptide during teeth movement.

  20. A preliminary investigation into the genetic variation and population structure of Taenia hydatigena from Sardinia, Italy.

    Science.gov (United States)

    Boufana, Belgees; Scala, Antonio; Lahmar, Samia; Pointing, Steve; Craig, Philip S; Dessì, Giorgia; Zidda, Antonella; Pipia, Anna Paola; Varcasia, Antonio

    2015-11-30

    Cysticercosis caused by the metacestode stage of Taenia hydatigena is endemic in Sardinia. Information on the genetic variation of this parasite is important for epidemiological studies and implementation of control programs. Using two mitochondrial genes, the cytochrome c oxidase subunit 1 (cox1) and the NADH dehydrogenase subunit 1 (ND1) we investigated the genetic variation and population structure of Cysticercus tenuicollis from Sardinian intermediate hosts and compared it to that from other hosts from various geographical regions. The parsimony cox1 network analysis indicated the existence of a common lineage for T. hydatigena and the overall diversity and neutrality indices indicated demographic expansion. Using the cox1 sequences, low pairwise fixation index (Fst) values were recorded for Sardinian, Iranian and Palestinian sheep C. tenuicollis which suggested the absence of genetic differentiation. Using the ND1 sequences, C. tenuicollis from Sardinian sheep appeared to be differentiated from those of goat and pig origin. In addition, goat C. tenuicollis were genetically different from adult T. hydatigena as indicated by the statistically significant Fst value. Our results are consistent with biochemical and morphological studies that suggest the existence of variants of T. hydatigena.

  1. Fractionating the role of executive control in control over worry: a preliminary investigation.

    Science.gov (United States)

    Hallion, Lauren S; Ruscio, Ayelet Meron; Jha, Amishi P

    2014-03-01

    Uncontrollable anxious thought characterizes a number of emotional disorders. Little is known, however, about the cognitive mechanisms that underlie the ability to control these thoughts. The present study investigated the extent to which two well-characterized executive control processes--working memory and inhibition--are engaged when an individual attempts to control worry. Participants completed a concurrent assessment of these processes while attempting to control personally-relevant worried and neutral thoughts. To examine the specificity of these effects to attempts to control worry, versus a residual "depletion" effect of having previously engaged in worry, a subset of participants completed the assessment without instructions to control their worried or neutral thoughts. Attempts to control worry engaged working memory and inhibition to a greater extent than did attempts to control neutral thought. This increased engagement was not explained solely by anxious affect, nor was it significantly associated with trait worry. Engagement did not differ by group, suggesting that executive control depletion by worry cannot be dismissed as an alternative explanation of these findings. These results highlight working memory and inhibition as potentially valuable constructs for deepening our understanding of the nature and treatment of worry and its control.

  2. Preliminary investigation of radon concentration in surface water and drinking water in Shenzhen City, South China.

    Science.gov (United States)

    Li, Ting; Wang, Nanping; Li, Shijun

    2015-11-01

    A radon survey in surface water and drinking water was conducted using a portable degassing system associated with an ionisation chamber AlphaGUARD (PQ2000) for understanding levels of dissolved radon ((222)Rn) concentration in different types of water sources and risk assessment of radon in drinking water in Shenzhen City (SC) with a population of 10 628 900 in 2013, Guangdong Province of China. The measurements show that arithmetic means ± standard deviations of radon ((222)Rn) concentration are 52.05 ± 6.64, 0.29 ± 0.26, 0.15 ± 0.23 and 0.37 ± 0.42 kBq m(-3) in spring water, surface water, large and small public water supplies, respectively. Only radon concentrations of two water samples collected in mountainous areas are more than 11.10 kBq m(-3), exceeding the limit of radon concentration in drinking water stipulated by the national standard of China (GB5749-2006). The annual effective doses due to radon in drinking water were also calculated. The investigation suggests that there are no risks caused by radon in the drinking water in SC.

  3. Preliminary investigation of relations between young students' self-regulatory strategies and their metacognitive experiences.

    Science.gov (United States)

    Dermitzaki, Irini

    2005-12-01

    The present study investigated second-graders' self-regulative behav ior during task engagement and its relations to performance and to students' on-line metacognitive experiences. Participants were 25 individually examined Greek second graders (13 boys and 12 girls; M age: 7.6 yr., SD = 0.2). Students' use of cognitive, metacognitive, and motivational regulatory strategies while performing a cognitive task were directly observed and recorded by two independent observers. Students' task-specific performance was also evaluated. Finally, students' feeling of satisfaction with the solution produced, their estimate of effort expenditure, and estimate of the solution's correctness were assessed. Analysis showed these second grade students' use of self-regulatory strategies and feeling of satisfaction were significantly associated with their performance. However, metacognitive experiences reported after the solution were only slightly related to the students' actual self-regulative behavior during the task, implying that the relations of students' regulatory efforts with their metacognitive processes are still developing at such a young age.

  4. Preliminary Investigation of a Dielectric Barrier Discharge Lamp in Open Air at Atmospheric Pressure

    Institute of Scientific and Technical Information of China (English)

    LIU Feng; WANG Wei-Wei; CHANG Xi-Jiang; LIANG Rong-Qing

    2011-01-01

    @@ A dielectric barrier discharge (DBD) lamp is investigated by using sinusoidal power with a 10 kHz frequency in open air at atmospheric pressure.With increasing applied voltages, the different discharge phenomena appear.At relatively low voltages, the discharge states are general stochastic filamentary discharges with weak light.However, at relatively high voltages, the walls of quartz tubes are heated sharply by plasma, and then the dazzling light is emitted very quickly to form the DBD Lamp, corresponding to the low maintaining voltage that is lower than the ignited voltage.The discharge state or mode of the DBD lamp that corresponds to the glow discharge is deduced according to the wave form of the circuit current, which is evidently different from the filamentary discharges.Under these conditions, the spectrum of the DBD lamp is continuous in the range 400-932nm, which is scanned in the range 300-932nm.It is also shown that there is another discharge state or mode that is different from the traditional filamentary discharges.Therefore, it is concluded that the discharge state or mode of the DBD lamp is a glow discharge.

  5. Preliminary Investigation for Engine Performance by Using Tire-Derived Pyrolysis Oil-Diesel Blended Fuels

    Science.gov (United States)

    Rofiqul, Islam M.; Haniu, Hiroyuki; Alam, Beg R.; Takai, Kazunori

    In the first phase of the present study, the pyrolysis oil derived from light automotive tire waste has been characterized including fuel properties, elemental analyses, FT-IR, 1H-NMR, GC-MS and distillation. The studies on the oil show that it can be used as liquid fuel with a gross calorific value (GCV) of 42.00 MJ/kg and empirical formula of CH1.27O0.025N0.006. In the second phase of the investigation, the performance of a diesel engine was studied blending the pyrolysis oil with diesel fuel in different ratios. The experimental results show that the bsfc of pyrolysis oil-diesel blended fuels slightly increases and hence the brake thermal efficiency decreases compared to those of neat diesel. The pyrolysis oil-diesel blends show lower carbon monoxide (CO) emission but higher oxides of nitrogen (NOx) emissions than those of neat diesel. However, NOx emissions with pyrolysis oil-diesel blended fuels reduced when EGR was applied.

  6. Voluntary emotion regulation in anorexia nervosa: A preliminary emotion-modulated startle investigation.

    Science.gov (United States)

    Racine, Sarah E; Forbush, Kelsie T; Wildes, Jennifer E; Hagan, Kelsey E; Pollack, Lauren O; May, Casey

    2016-06-01

    Emotion regulation difficulties are implicated in the development and maintenance of anorexia nervosa (AN). However, research has been limited by an almost exclusive reliance on self-report. This study is the first to use the emotion-modulated startle paradigm (EMSP) to investigate emotional reactivity and voluntary emotion regulation in individuals with AN. Twenty women with AN viewed negative, positive, neutral, and food images and were asked to enhance, suppress, or maintain their emotional responses mid-way through picture presentation. Startle eyeblink magnitudes in response to startle probes administered prior, and subsequent, to regulation instructions indexed emotional reactivity and regulation, respectively. On emotional reactivity trials, startle magnitudes were greater for negative, positive, and food images, compared to neutral images. Participants had difficulty suppressing startle responses to negative and food images, as indicated by non-significant suppress-maintain comparisons. In contrast, startle responses to enhance and suppress cues during presentation of pleasant images were comparable and significantly lower than maintain cues. Findings converge with self-report data to suggest that patients with AN have difficulties with voluntary emotion regulation. The EMSP may be a promising trans-diagnostic method for examining emotion regulation difficulties that underlie risk for eating disorders and other psychiatric conditions.

  7. Preliminary investigation into the pollution reduction performance of swales used in a stormwater treatment train.

    Science.gov (United States)

    Kachchu Mohamed, M A; Lucke, T; Boogaard, F

    2014-01-01

    Permeable pavements have been shown to be effective stormwater treatment devices that can greatly reduce surface runoff and significantly improve the quality of stormwater runoff in urban areas. However, the potential problems with sediment clogging and consequent maintenance requirements have been identified as the main barriers to more widespread adoption of permeable pavements in urban developments. This Australian study investigates the effectiveness of using grass swales as pre-treatment devices for permeable pavements in order to reduce clogging and extend the life span of these systems. The results of simulated runoff experiments demonstrated that between 50 and 75% of the total suspended sediment (TSS) was removed within the first 10 m of the swale length. This suggests swales of this length could potentially increase the effective life of permeable pavement systems by reducing clogging, and therefore maintenance. Nutrient removal was also tested in the study and the results indicated the tested swales were of limited effectiveness in the removal of these pollutants. However, in real runoff situations, reduction of TSS will have a direct influence on removing nutrients because a significant proportion of nutrients (and other pollutants) are attached to the sediments.

  8. Changes of Substance P in the Crevicular Fluid in relation to Orthodontic Movement Preliminary Investigation

    Science.gov (United States)

    Levrini, Luca; Sacerdote, Paola; Moretti, Sarah; Panzi, Silvia; Caprioglio, Alberto

    2013-01-01

    Substance P (SP) is a tachykinin released from both the central and the peripheral endings of primary afferent neurons and functions as a neurotransmitter. As a transmitter signaling pain, substance P is involved in nociception and is an extremely potent vasodilator. We found several studies about this neuropeptide especially in relation to parodontology and a few orthodontic reviews. This is because in the past the importance of this neuropeptide in dental element undergoing periodontal inflammation was observed. The aims of the present pilot study was to investigate whether the substance P was present in gingival crevicular fluid in dental elements undergoing orthodontic treatment with Invisalign technique compared to teeth belonging to the same series but not undergoing orthodontic movement. We analysed gengival crevicular fluid (GCF) collected from four young subjects, using a paper cone for a time of 60 seconds. The results showed that SP is present in the gengival sulcus in elements undergoing orthodontic forces during treatment with Invisalign technique and not in the control teeth. During the literature analysis, we have found a lot of papers describing involvement of SP in periodontitis and inflammatory diseases, but further studies are needed in order to demonstrate the role of this neuropeptide during teeth movement. PMID:23737731

  9. Impact of Nanoparticles on the Microstructure and Properties of Immiscible Polymer Blends: Preliminary Investigations

    Science.gov (United States)

    Filippone, G.; Acierno, D.

    2010-06-01

    The control of the morphology represents one of the most important aspects in designing polymer blends. A particular arrangement of the phases known as co-continuity can be promoted within a narrow range of compositions and using appropriate expedients during the mixing process. The distinguishing feature of co-continuous morphologies is the mutual interpenetration of the phases, which is often desirable as it may result in a remarkable combination of functional and structural properties of the blend constituents. Besides acting on the composition and processing conditions, adding nanoparticles in polymer systems with an existing phase-separated morphology such as polymer blends represents an innovative way to promote co-continuity in blends with low amounts of either phase. In the present work we focus on this topic, investigating the ability of nanoparticles to affect the morphology and properties of different kinds of immiscible polymer blends. In addition, the implications of the microstructural changes promoted by the filler on the high-temperature mechanical behavior of the blends are discussed.

  10. Properties of Compressed Stabilized Earth Blocks (CSEB For Low-Cost Housing Construction: A Preliminary Investigation

    Directory of Open Access Journals (Sweden)

    Baba Shehu Waziri

    2013-11-01

    Full Text Available Materials used for the construction of walls are normally required to possess adequate strength and erosion resistance. The study investigates the suitability of stabilized laterite soils for the production of compressed earth blocks for low-cost housing construction.  Soil samples for the experiment were obtained at two different locations. Sample I was obtained at a borrow pit along Gujba road in Damaturu Yobe state while Sample II was taken at a borrow pit near lake Alau in Borno sate, Nigeria. The results of the study revealed that the specific gravity, bulk density, moisture content and plasticity index of both samples showed satisfactory performance. Different cement stabilization levels of 0%, 2.5%, 5% and 7.5% were used to prepare the specimens for testing. The blocks were moulded using hand operated CINVA-Ram machine. The maximum compressive strength of 2.48N/mm2 was obtained with stabilization level of 7.5% with sample I at 28 days curing.  The strength of the specimens increases with increasing cement content with an average value of 0.35N/mm2. For higher strength requirements different stabilization options can be considered.

  11. Preliminary Single-Center Canadian Experience of Human Normothermic Ex Vivo Liver Perfusion: Results of a Clinical Trial.

    Science.gov (United States)

    Bral, M; Gala-Lopez, B; Bigam, D; Kneteman, N; Malcolm, A; Livingstone, S; Andres, A; Emamaullee, J; Russell, L; Coussios, C; West, L J; Friend, P J; Shapiro, A M J

    2017-04-01

    After extensive experimentation, outcomes of a first clinical normothermic machine perfusion (NMP) liver trial in the United Kingdom demonstrated feasibility and clear safety, with improved liver function compared with standard static cold storage (SCS). We present a preliminary single-center North American experience using identical NMP technology. Ten donor liver grafts were procured, four (40%) from donation after circulatory death (DCD), of which nine were transplanted. One liver did not proceed because of a technical failure with portal cannulation and was discarded. Transplanted NMP grafts were matched 1:3 with transplanted SCS livers. Median NMP was 11.5 h (range 3.3-22.5 h) with one DCD liver perfused for 22.5 h. All transplanted livers functioned, and serum transaminases, bilirubin, international normalized ratio, and lactate levels corrected in NMP recipients similarly to controls. Graft survival at 30 days (primary outcome) was not statistically different between groups on an intent-to-treat basis (p = 0.25). Intensive care and hospital stays were significantly more prolonged in the NMP group. This preliminary experience demonstrates feasibility as well as potential technical risks of NMP in a North American setting and highlights a need for larger, randomized studies. © 2016 The American Society of Transplantation and the American Society of Transplant Surgeons.

  12. Preliminary results from the investigation of the Pymatuning earthquake of September 25, 1998

    Science.gov (United States)

    Armbruster, John; Barton, Henry; Bodin, Paul; Buckwalter, Theodore; Cox, Jon; Cranswick, Edward; Dewey, James; Fleeger, Gary; Hopper, Margaret; Horton, Stephen; Hoskins, Donald; Kilb, Deborah; Meremonte, Mark; Metzger, Ann; Risser, Dennis; Seeber, Leonardo; Shedlock, Kaye; Stanley, Katherine; Withers, Mitchell; Zirbes, Madeleine

    1998-01-01

    The Pymatuning earthquake occurred on Friday, September 25, 1998, at 19:52:52 Universal Coordinated Time (UTC), or 3:52:52 p.m. EDT, near Jamestown, Pa., at the southern end of the Pymatuning Reservoir, which straddles the Ohio-Pennsylvania border. The National Earthquake Information Center (NEIC) determined that the event had a magnitude of 5.2 mbLg (a magnitude scale used to measure the size of earthquakes that are regional distances away [100 to 1,000 km, or 60 to 600 mi]), an epicenter of 41.5°N latitude, 80.4°W longitude, and an estimated depth of 5 km (3 mi). One person was reported injured as a result of being thrown to the ground by the earthquake, and it caused minor damage to buildings and seriously disrupted many water wells in the GreenvilleJamestown, Pa., area. The earthquake was generally felt over an area of approximately 200,000 km2 (77,230 mi2) throughout northern Ohio, western Pennsylvania and New York, and much of southern Ontario, Canada (see map on back cover). It was also felt as far west as Illinois and Wisconsin, as far east as New Jersey, Connecticut, and the District of Columbia, and as far south as Kentucky and Virginia. During the aftershock field investigation that commenced within 12 hours of the main shock, a World Wide Web site, http://groundmotion.cr.usgs.gov/pym/pym.htm>, was established from the field headquarters. The web site was used not only to transmit investigation results to the world in near real time but also to receive information from the local community as new earthquake effects were reported. As of March 1999, at least 11 aftershocks have occurred, the largest being a magnitude 2.3. The largest recent previous earthquake in the region was the northeastern Ohio (Leroy) earthquake of magnitude 5.0 that occurred on January 31, 1986, about 65 km (40 mi) west-northwest of the Pymatuning shock. This event was also felt by many of those who felt the Pymatuning earthquake. Similar to most of the seismicity east of the Rocky

  13. Wireless capsule endoscopy in the investigation of patients with chronic renal failure and obscure gastrointestinal bleeding (preliminary data)

    Institute of Scientific and Technical Information of China (English)

    Stephanos Karagiannis; Spyros Goulas; Georgios Kosmadakis; Petros Galanis; Dimitrios Arvanitis; John Boletis; Evangelos Georgiou; Christos Mavrogiannis

    2006-01-01

    AIM: To investigate the role of wireless capsule endoscopy (WCE) in detection of small bowel (SB) pathology in patients with chronic renal failure (CRF) and obscure bleeding.METHODS: Consecutive CRF patients with obscure bleeding were prospectively studied. Patients with normal renal function and obscure bleeding, investigated during the same period with WCE, were used for the interpretation of results.RESULTS: Seventeen CRF patients (11 overt, 6 occult bleeding) and 51 patients (33 overt, 18 occult bleeding) with normal renal function were enrolled in this study.Positive SB findings were detected in 70.6% of CRF patients and in 41.2% of non-CRF patients (P < 0.05). SB angiodysplasia was identified in 47% of CRF patients and in 17.6% of non-CRF patients. Univariate logistic regression revealed CRF as a significant predictive factor for angiodysplasia (P < 0.05). Therapeutic measures were undertaken in 66% of the patients with the positive findings.CONCLUSION: According to our preliminary results, SB angiodysplasia was found in an increased prevalence among CRF patients with obscure bleeding. WCE is useful in diagnosis of gastrointestinal pathologies and in planning appropriate therapeutic intervention and, therefore, should be included in the work-up of this group of patients.

  14. Multifractal detrended fluctuation analysis of human EEG: preliminary investigation and comparison with the wavelet transform modulus maxima technique.

    Directory of Open Access Journals (Sweden)

    Todd Zorick

    Full Text Available Recently, many lines of investigation in neuroscience and statistical physics have converged to raise the hypothesis that the underlying pattern of neuronal activation which results in electroencephalography (EEG signals is nonlinear, with self-affine dynamics, while scalp-recorded EEG signals themselves are nonstationary. Therefore, traditional methods of EEG analysis may miss many properties inherent in such signals. Similarly, fractal analysis of EEG signals has shown scaling behaviors that may not be consistent with pure monofractal processes. In this study, we hypothesized that scalp-recorded human EEG signals may be better modeled as an underlying multifractal process. We utilized the Physionet online database, a publicly available database of human EEG signals as a standardized reference database for this study. Herein, we report the use of multifractal detrended fluctuation analysis on human EEG signals derived from waking and different sleep stages, and show evidence that supports the use of multifractal methods. Next, we compare multifractal detrended fluctuation analysis to a previously published multifractal technique, wavelet transform modulus maxima, using EEG signals from waking and sleep, and demonstrate that multifractal detrended fluctuation analysis has lower indices of variability. Finally, we report a preliminary investigation into the use of multifractal detrended fluctuation analysis as a pattern classification technique on human EEG signals from waking and different sleep stages, and demonstrate its potential utility for automatic classification of different states of consciousness. Therefore, multifractal detrended fluctuation analysis may be a useful pattern classification technique to distinguish among different states of brain function.

  15. Work plan for preliminary investigation of organic constituents in ground water at the New Rifle site, Rifle, Colorado. Revision 2

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-01-01

    A special study screening for Appendix 9 (40 CFR Part 264) analytes identified the New Rifle site as a target for additional screening for organic constituents. Because of this recommendation and the findings in a recent independent technical review, the US Department of Energy (DOE) has requested that the Technical Assistance Contractor (TAC) perform a preliminary investigation of the potential presence of organic compounds in the ground water at the New Rifle Uranium Mill Tailings Remedial Action (UMTRA) Project site, Rifle, Colorado. From 1958 to 1972, organic chemicals were used in large quantities during ore processing at the New Rifle site, and it is possible that some fraction was released to the environment. Therefore, the primary objective of this investigation is to determine whether organic chemicals used at the milling facility are present in the ground water. The purpose of this document is to describe the work that will be performed and the procedures that will be followed during installation of ground water well points at the New Rifle site. The selection of analytes and the procedures for collecting ground water samples for analysis of organic constituents are also described.

  16. α-Tocopherol/chitosan-based nanoparticles: characterization and preliminary investigations for emulsion systems application

    Science.gov (United States)

    Aresta, Antonella; Calvano, Cosima Damiana; Trapani, Adriana; Zambonin, Carlo Giorgio; De Giglio, Elvira

    2014-02-01

    The processes of lipids oxidation represent a great concern for the consumer health because they are one of the major causes of quality deterioration in fat-containing products. One of the most effective methods of delaying lipid oxidation consists in incorporating antioxidants. The present investigation describes the formulation of chitosan and novel glycol chitosan nanoparticles (NPs) loaded with α-Tocopherol (αToc-NPs). The obtained NPs were characterized by various techniques, such as particle size (showing mean diameters in the range 335-503 nm) and zeta potential measurements, X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy. The NPs were, then, added in the preparation of oil-in-water simple emulsion both to make the lipophilic αToc available in an aqueous medium and to prevent emulsion oxidation. For this purpose, a new highly sensitive, simple and solvent-free method based on a solid phase microextraction (SPME) coupled to gas chromatography mass spectrometry was developed for the determination of αToc in aqueous medium. All the parameters influencing SPME, including fiber coating, time and temperature extraction, pH, ionic strength and desorption conditions, have been carefully screened. The method was successfully applied to the determination of vitamin in the αToc-NPs and its release from NPs-enriched simple emulsion formulations. SPME provided high recovery yields and the limits of detection and of quantification in emulsion were 0.1 and 0.5 μg/mg, respectively. The precision of the method has been also estimated. The delay of the lipid oxidation by the proposed formulations has been evaluated exploiting the Kreis test on αToc-NPs-enriched emulsions.

  17. Preliminary Investigation of Keyhole Phenomena during Single Layer Fabrication in Laser Additive Manufacturing of Stainless Steel

    Science.gov (United States)

    Matilainen, Ville-Pekka; Piili, Heidi; Salminen, Antti; Nyrhilä, Olli

    Laser additive manufacturing (LAM) is a fabrication technology that enables production of complex parts from metallic materials with mechanical properties comparable to conventionally manufactured parts. In the LAM process, parts are manufactured by melting metallic powder layer-by-layer with a laser beam. This manufacturing technology is nowadays called powder bed fusion (PBF) according to the ASTM F2792-12a standard. This strategy involves several different independent and dependent thermal cycles, all of which have an influence on the final properties of the manufactured part. The quality of PBF parts depends strongly on the characteristics of each single laser-melted track and each single layer. This study consequently concentrates on investigating the effects of process parameters such as laser power on single track and layer formation and laser-material interaction phenomena occurring during the PBF process. Experimental tests were done with two different machines: a modified research machine based on an EOS EOSINT M-series system and an EOS EOSINT M280 system. The material used was EOS stainless steel 17-4 PH. Process monitoring was done with an active illuminated high speed camera system. After microscopy analysis, it was concluded that a keyhole can form during laser additive manufacturing of stainless steel. It was noted that heat input has an important effect on the likelihood of keyhole formation. The threshold intensity value for keyhole formation of 106 W/cm2 was exceeded in all manufactured single tracks. Laser interaction time was found to have an effect on penetration depth and keyhole formation, since the penetration depth increased with increased laser interaction time. It was also concluded that active illuminated high speed camera systems are suitable for monitoring of the manufacturing process and facilitate process control.

  18. Is orientation week a gateway to persistent alcohol use in university students? A preliminary investigation.

    Science.gov (United States)

    Riordan, Benjamin C; Scarf, Damian; Conner, Tamlin S

    2015-03-01

    Orientation Week is common at many universities throughout the world and is a way to introduce students to their new environment. Despite some benefits, Orientation Week is often typified by heavy alcohol use. Although typically viewed as a "one-time" event, the higher levels of drinking that students engage in during Orientation Week may persist into the academic year. We investigated this possibility in the present study. Freshman-year students (n = 143; 41% male) residing in a dormitory were surveyed about their alcohol intake before university. During Orientation Week, students were sent a daily text message asking about the number of drinks they consumed the previous night. Then, during the academic year, students were sent one text message each month to record their weekend drinking. Participants consumed a higher number of standard drinks during Orientation Week (M = 26.0, SD = 28.6) than they did either before entering university (M = 13.1, SD = 13.6) or during the academic year (M = 6.4, SD = 8.5). For male students, but not female students, higher Orientation Week drinking uniquely contributed to higher rates of drinking during the academic year when controlling for pre-university drinking (b = 0.122, p Students who drank at low levels before entering university were particularly susceptible to the negative effects of Orientation Week drinking. Orientation Week may act as a gateway for male students, as drinking during Orientation Week predicted their subsequent drinking throughout the academic year. Based on these findings, Orientation Week could be a prime period for interventions aimed at curbing academic-year drinking.

  19. 21 CFR 312.40 - General requirements for use of an investigational new drug in a clinical investigation.

    Science.gov (United States)

    2010-04-01

    ... new drug in a clinical investigation. 312.40 Section 312.40 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS FOR HUMAN USE INVESTIGATIONAL NEW DRUG APPLICATION Administrative Actions § 312.40 General requirements for use of an investigational new drug in...

  20. A preliminary study of the effect of eliminating requirements on clinical performance.

    Science.gov (United States)

    Dodge, W W; Dale, R A; Hendricson, W D

    1993-09-01

    This study determined the effect of a clinical program driven by patient needs upon students' productivity, attitudes, and academic performance. A group of eight senior students, whose academic and clinical performance profile replicated that of the rest of the class, were chosen to participate in a year-long non-requirement clinic. The students were expected to attend all clinic sessions, and treat their assigned patients. Their performance was compared to that of classmates in the regular requirement-driven curriculum. The non-requirement group had significantly higher academic achievement and significantly outproduced their classmates. Non-requirement students had no state board failures, versus 17 percent in the regular curriculum, and reported significantly lower stress. This study suggests that predoctoral clinical programs can maintain quality and productivity in the absence of unit requirements.

  1. A preliminary study investigating the factors influencing STEM major selection by African American females

    Science.gov (United States)

    Ray, Tiffany Monique

    The purpose of this study was to investigate the significant factors influencing STEM major selection by African American females. A quantitative research design with a qualitative component was employed. Ex post facto survey research was conducted utilizing an online questionnaire to collect data from participants. African American undergraduate females that had declared a major in STEM comprised the target population for the study. As a basis for comparison, a second data collection ensued. All non-African American undergraduate females majoring in STEM also received the survey instrument to determine if there was a significant difference between factors that influence STEM major selection between the two groups. The Social Cognitive Career Choice Model comprised the conceptual framework for this study. Frequencies and percentages illustrated the demographic characteristics of the sample, as well as the average influence levels of each of the items without regard for level of significance. The researcher conducted an independent samples t-test to compare the mean scores for undergraduate African American females majoring in STEM and non-African American females majoring in STEM on each influential factor on the survey instrument. The researcher coded responses to open-ended questions to generate themes and descriptions. The data showed that African American female respondents were very influenced by the following items: specific interest in the subject, type of work, availability of career opportunities after graduation, parent/guardian, precollege coursework in science, and introductory college courses. In addition, the majority of respondents were very influenced by each of the confidence factors. African American females were overwhelmingly not influenced by aptitude tests. African American females were more influenced than their non-African American female counterparts for the following factors: reputation of the university, college or department, high level

  2. Preliminary investigation into the design of thermally responsive Forster resonance energy transfer colloids

    Science.gov (United States)

    Bedford, Monte Scott

    While nuclear imaging techniques (Magnetic Resonance Imaging, Computed Tomography, and Positron Emission Tomography) have proven effective for diagnosis and treatment of disease in the human body, fluorescence-enhanced optical imaging offers additional benefits. Fluorescent imaging provides high resolution with real-time response, persistent lifetime (hours to days), cell targeting, and transdermal penetration with minimal physical encumbrance. Malignant cells can be targeted by absorbance of exogenous fluorescent nanoprobe contrast agents. Imaging is improved by fluorescent enhancement, especially by energy transfer between attached dyes. Also for use against cancer are heat-active treatments, such as hyperthermal, photothermal, and chemothermal therapies. Helpful to these treatments is the thermal response from nanoprobes, within human cells, which provide real-time feedback. The present study investigates the design and feasibility of a nanoprobe molecular device, absorbable into malignant human cells, which provides real-time tracking and thermal response, as indicated by enhanced fluorescence by energy transfer. A poly(propargyl acrylate) colloidal suspension was synthesized. The particles were modified with a triblock copolymer, previously shown to be thermally responsive, and an end-attached fluorescent dye. A second dye was modeled for attachment in subsequent work. When two fluorescent dyes are brought within sufficiently close proximity, and excitation light is supplied, energy can be transferred between dyes to give enhanced fluorescence with a large Stokes shift (increase in wavelength between excitation and emission). The dye pair was modeled for overlap of emission and absorbance wavelengths, and energy transfer was demonstrated with 23% efficiency and a 209 nm Stokes shift. The quantum yield of the donor dye was determined at 70%, and the distance for 50% energy transfer was calculated at 2.9 nm, consistent with reports for similar compounds. When

  3. Preliminary investigation on the role of microorganisms in the production of phosphine

    Institute of Scientific and Technical Information of China (English)

    Liu Zhipei; Jia Shengfen; Wang Baojun; Zhang Tao; Liu Shuangjiang

    2008-01-01

    The relationships between the phosphine content and various microbial populations, activities of different enzymes were investigated firstly. The results indicated that the phosphine content of samples from various environments was positively related to total anaerobic microorganisms, organic phosphate compound-dissolving bacteria, denitrifying bacteria, and the activities of alkaline phosphatase and dehydrogenase, with correlation coefficients (R2) up to 0.93, 0.90, 0.69, 0.79, and 0.82, respectively. Results also showed that the phosphine content was not related to total aerobic microorganisms, inorganic phosphate compound-dissolving bacteria, sulfate-reducing bacteria, and the acidic phosphatase activity. Nutrients such as yeast extract and glucose were added, at a time and individually, to normal or autoclaved soil samples. The soil samples were inoculated with sulfate-reducing bacterial enrichments (SRB) and/or denitrifying bacterial enrichment (DNB). After incubation for one month at 30℃, the phosphane content of these samples was analyzed. The results indicated that the addition of glucose or yeast extract could greatly increase the phosphane content. Moreover, it was revealed that inoculation with SRB or DNB could also promote the formation of phosphine. The DNB, however, was more efficient in this regard. The highest phosphine content, about 5 times that of the control, was detected in the sample that was added with both glucose and yeast extract and inoculated with SRB and DNB simultaneously. SRB and DNB were enriched for several generations and the phosphane content of different generations was analyzed. Furthermore, SRB and DNB enrichments were inoculated into different media, in the beginning of enriching, the phosphane content was about the same for different enrichments, and differed more significantly as the enrichment process was carried further. In forth generation, the phosphane content of DNB enrichment was about 3 times of that of SRB

  4. Preliminary investigation of cardiopulmonary function in stroke patients with stable heart failure and exertional dyspnea

    Science.gov (United States)

    Liaw, Mei-Yun; Wang, Lin-Yi; Pong, Ya-Ping; Tsai, Yu-Chin; Huang, Yu-Chi; Yang, Tsung-Hsun; Lin, Meng-Chih

    2016-01-01

    Abstract The aim of this study was to investigate the relationships between pulmonary function, respiratory muscle strength, perceived dyspnea, degree of fatigue, and activity of daily living with motor function and neurological status in stroke patients with stable congestive heart failure (CHF). This was a cohort study in a tertiary care medical center. Stroke patients with CHF and exertional dyspnea (New York Heart Association class I–III) were recruited. The baseline characteristics included duration of disease, Brunnstrom stage, spirometry, resting heart rate, resting oxyhemoglobin saturation (SpO2), maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), Borg scale, fatigue scale, and Barthel index. A total of 47 stroke patients (24 males, 23 females, mean age 65.9 ± 11.5 years) were included. The average Brunnstrom stages of affected limbs were 3.6 ± 1.3 over the proximal parts and 3.5 ± 1.4 over the distal parts of upper limbs, and 3.9 ± 0.9 over lower limbs. The average forced vital capacity (FVC) was 2.0 ± 0.8 L, with a predicted FVC% of 67.9 ± 18.8%, forced expiratory volume in the first second (FEV1) of 1.6 ± 0.7 L, predicted FEV1% of 70.6 ± 20.1%, FEV1/FVC of 84.2 ± 10.5%, and maximum mid-expiratory flow of 65.4 ± 29.5%. The average MIP and MEP were −52.9 ± 33.3 cmH2O and 60.8 ± 29.0 cmH2O, respectively. The Borg scale was 1.5 ± 0.8. MIP was negatively associated with the average Brunnstrom stage of the proximal (r = −0.318, P lower extremities (r = −0.288, P lower extremities (r = −0.311, P limbs. FVC was more strongly associated with MIP and MEP than predicted FVC%. FEV1/FVC may be used as a reference for the pulmonary dysfunction. PMID:27749577

  5. Clinical Investigations and Management of Refractive Changes in ...

    African Journals Online (AJOL)

    AJRH Managing Editor

    observed that all women who complained of visual ... pregnancy, there was no history of hypertension ... Visual acuity became worse with – 1.00Ds 20/160. ..... archive for clinical and experimental ophthalmology. 2003; 24 (6): 484-492. 6.

  6. Preliminary clinical results: an analyzing tool for 2D optical imaging in detection of active inflammation in rheumatoid arthritis

    Science.gov (United States)

    Adi Aizudin Bin Radin Nasirudin, Radin; Meier, Reinhard; Ahari, Carmen; Sievert, Matti; Fiebich, Martin; Rummeny, Ernst J.; No"l, Peter B.

    2011-03-01

    Optical imaging (OI) is a relatively new method in detecting active inflammation of hand joints of patients suffering from rheumatoid arthritis (RA). With the high number of people affected by this disease especially in western countries, the availability of OI as an early diagnostic imaging method is clinically highly relevant. In this paper, we present a newly in-house developed OI analyzing tool and a clinical evaluation study. Our analyzing tool extends the capability of existing OI tools. We include many features in the tool, such as region-based image analysis, hyper perfusion curve analysis, and multi-modality image fusion to aid clinicians in localizing and determining the intensity of inflammation in joints. Additionally, image data management options, such as the full integration of PACS/RIS, are included. In our clinical study we demonstrate how OI facilitates the detection of active inflammation in rheumatoid arthritis. The preliminary clinical results indicate a sensitivity of 43.5%, a specificity of 80.3%, an accuracy of 65.7%, a positive predictive value of 76.6%, and a negative predictive value of 64.9% in relation to clinical results from MRI. The accuracy of inflammation detection serves as evidence to the potential of OI as a useful imaging modality for early detection of active inflammation in patients with rheumatoid arthritis. With our in-house developed tool we extend the usefulness of OI imaging in the clinical arena. Overall, we show that OI is a fast, inexpensive, non-invasive and nonionizing yet highly sensitive and accurate imaging modality.-

  7. 21 CFR 312.70 - Disqualification of a clinical investigator.

    Science.gov (United States)

    2010-04-01

    ... are essential to the continuation of the investigation or essential to the approval of any marketing... Research or the Center for Biologics Evaluation and Research will furnish the investigator written notice... but not accepted by the Center for Drug Evaluation and Research or the Center for Biologics...

  8. Palaeomagnetic, rock-magnetic and mineralogical investigations of metadolerites from Western Svalbard : A preliminary report

    Science.gov (United States)

    Michalski, Krzysztof; Nejbert, Krzysztof; Domańska-Siuda, Justyna; Manby, Geoffrey

    2014-05-01

    A group of 42 independently oriented palaeomagnetic samples from 7 sites located in central part of the West Spitsbergen Thrust and Fault Belt has been investigated. The samples were collected from 5 distinct metadolerite sheets intruded into the Proterozoic - Lower Paleozoic metamorphic complex of Western Oscar II Land (Western Svalbard Caledonian Terrane - Harland, 1997 division). All analyzed metadolerite samples were metamorphosed under greenschist facies metamorphism. The metamorphic assemblage consist of hornblende, biotite, actinolite, chlorite, epidote, stilpnomelane, titanite, albite, and quartz. Calcite, associated with pyrrhotite, pyrite chalcopyrite, sphalerite, and covellite, that occurs as irregular intergrowths or thin veins, document high activity of H2O-CO2-rich fluids during metamorphism. Primary magmatic phases represented by clinopyroxene occur rarely, and only in thick metadolerite dykes. Accessory oxides change their mineralogical and chemical composition during metamorphism. In all examined samples primary Ti-magnetite and oxy-exsolved hematite break-down completely into titanite or have been dissolved. The ilmenite are also replaced by titanite, but in metadolerites at contact with host metapelites, slightly altered ilmenite grains with preserved hematite exsolution were documented. Basing on mineralogical observations it should be expected that metamorphic processes have almost completely reset the paleomagnetic data record from the time of dolerite crystallization. This stage can document only rare hematite oxy-exsolution preserved within ilmenite, and presumably small inclusion of magnetite still preserved within unaltered clinopyroxene. The paleomagnetic record of metamorphic stage is probably recorded by pyrrhotite, hematite, goethite, and late Ti-free magnetite that can grow during breakdown of pyrrhotite to pyrite (Ramdohr. 1980). The NRM (Natural Remanent Magnetisation) intensities of the palaeomagnetic samples exceed the minimum 10

  9. The Relationship of Clinical, Cognitive and Social Measures in Schizophrenia: A Preliminary Finding Combining Measures in Probands and Relatives

    Science.gov (United States)

    Huepe, David; Riveros, Rodrigo; Manes, Facundo; Couto, Blas; Hurtado, Esteban; Cetkovich, Marcelo; Escobar, Maria; Vergara, Viviana; Parrao, Teresa; Ibañez, Agustin

    2012-01-01

    This study examines performance of schizophrenia patients, unaffected relatives and controls in social cognition, cognitive and psychiatric scales looking for possible markers of vulnerability in schizophrenia. Performance of schizophrenia patients from multiplex families, first-degree relatives, and matched controls was compared and, subsequently, discriminant analysis method was used for identifying the best predictors for group membership. By using Multigroup Discriminant Analyses on the three groups, the best predictors were PANSS, Premorbid Adjustment Scale, Faux Pas test, and a face/emotion categorizing task. This model obtained 82% correct global classification, suggesting that the combination of psychiatric scales and neuropsychological/social cognition tesks are the best approach for characterizing this disease. Although preliminary, our results suggest that social cognition tasks are robust markers of schizophrenia family impairments, and that combining clinical, social and neuropsychological measures is the best approach to asses patients and relatives vulnerability. PMID:22425724

  10. The Relationship of Clinical, Cognitive and Social Measures in Schizophrenia: A Preliminary Finding Combining Measures in Probands and Relatives

    Directory of Open Access Journals (Sweden)

    David Huepe

    2012-01-01

    Full Text Available This study examines performance of schizophrenia patients, unaffected relatives and controls in social cognition, cognitive and psychiatric scales looking for possible markers of vulnerability in schizophrenia. Performance of schizophrenia patients from multiplex families, first-degree relatives, and matched controls was compared and, subsequently, discriminant analysis method was used for identifying the best predictors for group membership. By using Multigroup Discriminant Analyses on the three groups, the best predictors were PANSS, Premorbid Adjustment Scale, Faux Pas test, and a face/emotion categorizing task. This model obtained 82% correct global classification, suggesting that the combination of psychiatric scales and neuropsychological/social cognition tesks are the best approach for characterizing this disease. Although preliminary, our results suggest that social cognition tasks are robust markers of schizophrenia family impairments, and that combining clinical, social and neuropsychological measures is the best approach to asses patients and relatives vulnerability.

  11. Selection of Sperm Based on Hypo-Osmotic Swelling May Improve ICSI Outcome: A Preliminary Prospective Clinical Trial

    Directory of Open Access Journals (Sweden)

    Nasim Charehjooy

    2014-03-01

    Full Text Available Background: The intra-cytoplasmic sperm injection (ICSI technique selects sperm according to morphology and motility. However, these parameters cannot predict the chromatin integrity of sperm. Considering the detrimental effects of DNA-damaged sperm on reproductive outcomes, novel sperm selection procedures have been proposed to circumvent the possibility of inseminating DNA-damaged sperm. It has been shown that different potential hypo-osmotic swelling test (HOST patterns possess the potential to differentiate between sperm that have intact or damaged chromatin. Therefore, for the first time, this preliminary study evaluates the role of HOST as a sperm selection procedure in a clinical setting. Materials and Methods: In this preliminary prospective clinical trial study, we divided infertile couples diagnosed with male infertility into two groups. In the treatment group (n=39, half of the oocytes were inseminated by sperm selected following density gradient centrifugation (DGC group. The remaining oocytes from the treatment group were inseminated by sperm chosen according to HOST pattern (c, d or e following DGC processing (HOST group. In the control group (n=63, all oocytes were inseminated by sperm chosen after DGC. Results: There was a significantly higher percentage of embryos that had good quality, implantation, and chemical pregnancy rates in the HOST group compared to the DGC group (p≤0.05. Conclusion: This study has shown that selecting sperm according to membrane functionality (HOST pattern rather morphology and viability may open a new window in our approach for determining the appropriate sperm for ICSI, particularly in individuals with severe male infertility (Registration Number: IRCT201307087223N2.

  12. [Investigation on cognition of zoonosis among veterinary clinical staff].

    Science.gov (United States)

    Takinami, Kenji

    2005-10-01

    We conducted a survey to determine how much veterinary clinic staff, including veterinary surgeon and veterinary technicians, know about zoonosis. Response was 52.5%. All staff members knew of zoonosis. Staff members who knew what zoonosis meant accounted for 98%. Staff members trained in zoonosis accounted for 75% among veterinary surgeons and 66% among veterinary technicians. Staff members who thought that zoonosis would increase in future accounted for 92% among veterinary surgeons and 79% among veterinary technicians. Staff members who were asked by pet owners about zoonosis accounted for 87% among veterinary surgeons and 51% among veterinary technicians. Staff members who thought veterinary surgeons must report zoonosis to public health centers accounted for 96% among veterinary surgeons and 88% among veterinary technicians. Veterinary clinic staffs thus had correct knowledge and were aware of zoonosis. The network of medical staff and veterinary staff could therefore build on this result.

  13. Clinical investigations for SUS, the Brazilian public health system

    OpenAIRE

    Ana Patrícia Paula; Silvana Pereira Giozza; Michelle Zanon Pereira; Patrícia Souza Boaventura; Leonor Maria Pacheco Santos; Camile Giaretta Sachetti; César Omar Carranza Tamayo; Clarissa Campos Guaragna Kowalski; Flavia Tavares Silva Elias; Suzanne Jacob Serruya; Reinaldo Guimarães

    2012-01-01

    CONTEXT AND OBJECTIVE: Scientific and technological development is crucial for advancing the Brazilian health system and for promoting quality of life. The way in which the Brazilian Ministry of Health has supported clinical research to provide autonomy, self-sufficiency, competitiveness and innovation for the healthcare industrial production complex, in accordance with the National Policy on Science, Technology and Innovation in Healthcare, was analyzed. DESIGN AND SETTING: Descriptive inves...

  14. Clinical Investigation Program. Annual Progress Report. Volume 1

    Science.gov (United States)

    1994-01-20

    conducting, and publishing ethical, scientific inquiry into clinical health problems of beneficiaries of the military health care system, to include... Acromegaly and 173 Intermediate Markers of Neoplasia (5/90) 1417 Wong, Roy COL MC. Incidence of Gastric Mucosal Injury in 174 Patients Ingesting Liquid Versus... Respiratory 225 Control Mechanisms and Nocturnal Desaturation in Diffuse Pulmonary Fibrosis (2/81) 1714 Dillard, Thomas LTC MC. Mechanisms Limiting Exercise

  15. Clinical investigation of set-shifting subtypes in anorexia nervosa.

    Science.gov (United States)

    Abbate-Daga, Giovanni; Buzzichelli, Sara; Marzola, Enrica; Amianto, Federico; Fassino, Secondo

    2014-11-30

    While evidence continues to accumulate on the relevance of cognitive inflexibility in anorexia nervosa (AN), its clinical correlates remain unclear. We aimed at examining the relationship between set-shifting and clinical variables (i.e., eating psychopathology, depression, and personality) in AN. Ninety-four individuals affected by AN and 59 healthy controls (HC) were recruited. All participants were assessed using: Eating Disorders Inventory-2 (EDI-2), Temperament and Character Inventory (TCI), Beck Depression Inventory (BDI), and Wisconsin Card Sorting Test (WCST). The AN group scored worse than HCs on set-shifting. According to their neuropsychological performances, AN patients were split into two groups corresponding to poor (N=30) and intact (N=64) set-shifting subtypes. Interoceptive awareness, impulse regulation, and maturity fears on the EDI-2 and depression on the BDI differed across all groups (HC, intact, and poor set-shifting subtype). Self-directedness on the TCI differed significantly among all groups. Cooperativeness and reward dependence differed instead only between HC and AN poor set-shifting subtype. After controlling for depression, only interoceptive awareness remained significant with reward dependence showing a trend towards statistical significance. These findings suggest that multiple clinical variables may be correlated with set-shifting performances in AN. The factors contributing to impaired cognitive inflexibility could be more complex than heretofore generally considered.

  16. Preliminary safety evaluation for the Simpevarp subarea. Based on data and site descriptions after the initial site investigation stage

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-04-01

    The main objectives of this Preliminary safety evaluation (PSE) of the Simpevarp subarea are: to determine, whether the feasibility study's judgement of the suitability of the candidate area with respect to long-term safety holds up in the light of the site investigation data; to provide feedback to continued site investigations and site-specific repository design and to identify site specific scenarios and geoscientific issues for further analyses. The PSE focuses on comparing the attained knowledge of the sites with the suitability criteria as set out by SKB in the report SKB-TR--00-12. These criteria both concern properties of the site judged to be necessary for safety and engineering (requirements) and properties judged to be beneficial (preferences). The findings are then evaluated in order to provide feedback to continued investigations and design work. The PSE does not aim at comparing sites and does not assess compliance with safety and radiation protection criteria. The evaluation shows that even considering remaining uncertainties, the Simpevarp subarea meets all safety requirements and most of the safety preferences. Consequently, from a safety point of view, there is no reason not to continue the Site Investigations of the Simpevarp subarea. There are still uncertainties to resolve and the safety would eventually need to be verified through a full safety assessment. Still, this Preliminary Safety Evaluation demonstrates that it is likely that a safe repository for spent nuclear fuel of the KBS-3 type could be constructed at the site. The following feedback is provided to the site investigations and the associated site modelling: Reducing the uncertainty on the deformation zone geometry within the Simpevarp subarea would allow for a more specified layout, although the sensitivity analysis shows that the space needed is rather robust with respect to uncertainties in the zones. There is substantial uncertainty in the discrete fracture network (DFN

  17. MR elastography of the liver at 3.0 T in diagnosing liver fibrosis grades; preliminary clinical experience

    Energy Technology Data Exchange (ETDEWEB)

    Yoshimitsu, Kengo; Mitsufuji, Toshimichi; Shinagawa, Yoshinobu; Fujimitsu, Ritsuko; Morita, Ayako; Urakawa, Hiroshi; Takano, Koichi [Fukuoka University, Department of Radiology, Fukuoka (Japan); Hayashi, Hiroyuki [Fukuoka University, Department of Pathology, Faculty of Medicine, Fukuoka (Japan)

    2016-03-15

    To clarify the usefulness of 3.0-T MR elastography (MRE) in diagnosing the histological grades of liver fibrosis using preliminary clinical data. Between November 2012 and March 2014, MRE was applied to all patients who underwent liver MR study at a 3.0-T clinical unit. Among them, those who had pathological evaluation of liver tissue within 3 months from MR examinations were retrospectively recruited, and the liver stiffness measured by MRE was correlated with histological results. Institutional review board approved this study, waiving informed consent. There were 70 patients who met the inclusion criteria. Liver stiffness showed significant correlation with the pathological grades of liver fibrosis (rho = 0.89, p < 0.0001, Spearman's rank correlation). Areas under the receiver operating characteristic curve were 0.93, 0.95, 0.99 and 0.95 for fibrosis score greater than or equal to F1, F2, F3 and F4, with cut-off values of 3.13, 3.85, 4.28 and 5.38 kPa, respectively. Multivariate analysis suggested that grades of necroinflammation also affected liver stiffness, but to a significantly lesser degree as compared to fibrosis. 3.0-T clinical MRE was suggested to be sufficiently useful in assessing the grades of liver fibrosis. (orig.)

  18. Game-Based Cognitive-Behavioral Therapy (GB-CBT) Group Program for Children Who Have Experienced Sexual Abuse: A Preliminary Investigation

    Science.gov (United States)

    Misurell, Justin R.; Springer, Craig; Tryon, Warren W.

    2011-01-01

    This preliminary investigation examined the efficacy of a game-based cognitive-behavioral therapy group program for elementary school-aged children who have experienced sexual abuse. Treatment aimed to improve: (a) internalizing symptoms, (b) externalizing behaviors, (c) sexually inappropriate behaviors, (d) social skills deficits, (e) self-esteem…

  19. Game-Based Cognitive-Behavioral Therapy (GB-CBT) Group Program for Children Who Have Experienced Sexual Abuse: A Preliminary Investigation

    Science.gov (United States)

    Misurell, Justin R.; Springer, Craig; Tryon, Warren W.

    2011-01-01

    This preliminary investigation examined the efficacy of a game-based cognitive-behavioral therapy group program for elementary school-aged children who have experienced sexual abuse. Treatment aimed to improve: (a) internalizing symptoms, (b) externalizing behaviors, (c) sexually inappropriate behaviors, (d) social skills deficits, (e) self-esteem…

  20. Preliminary investigation of the effect of air-pollution-control residue from waste incineration on the properties of cement paste and mortar

    DEFF Research Database (Denmark)

    Geiker, Mette Rica; Kjeldsen, Ane Mette; Galluci, Emmanuel

    2006-01-01

    For preliminary assessment of the engineering properties of concrete with air-pollution-control residue from waste incineration (APC) the possible reactivity of APC and the effect of APC on cement hydration were investigated by isothermal calorimetry, chemical shrinkage (pychnometry), thermal...

  1. Preliminary safety evaluation for the Forsmark area. Based on data and site descriptions after the initial site investigation stage

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, Johan [JA Streamflow AB, Aelvsjoe (Sweden)

    2005-08-01

    The main objectives of this Preliminary Safety Evaluation (PSE) of the Forsmark area have been to determine, with limited efforts, whether the feasibility study's judgement of the suitability of the candidate area with respect to long-term safety holds up in the light of the actual site investigation data; to provide feedback to continued site investigations and site-specific repository design and to identify site-specific scenarios and geoscientific issues for further analyses. The PSE focuses on comparing the attained knowledge of the sites with the suitability criteria as set out by SKB. The PSE does not aim at comparing sites and does not assess compliance with safety and radiation protection criteria. The evaluation shows that, even considering remaining uncertainties, the Forsmark area meets all stated safety requirements and preferences. Consequently, from a safety point of view, there is no reason not to continue the Site Investigations of the Forsmark area. There are still uncertainties to resolve and the safety would eventually need to be verified through a full safety assessment. Nevertheless, this Preliminary Safety Evaluation demonstrates that it is likely that a safe repository for spent nuclear fuel of the KBS-3 type could be constructed at the site. The following feedback is provided to the site investigations and the associated site modelling: Reducing the uncertainty on the deformation zone geometry inside the target area would be needed to more firmly define locations of the suitable deposition volumes. There is substantial uncertainty in the Discrete Fracture Network model. Further reduction of the uncertainties, if needed, would probably only be possible from the underground, detailed investigation phase. Efforts need also be spent on improving the DFN-modelling. There are assumptions made in current models that could be challenged and there seems to be room for better use of the borehole information. It is particularly important to

  2. Preliminary safety evaluation for the Forsmark area. Based on data and site descriptions after the initial site investigation stage

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, Johan [JA Streamflow AB, Aelvsjoe (Sweden)

    2005-08-01

    The main objectives of this Preliminary Safety Evaluation (PSE) of the Forsmark area have been to determine, with limited efforts, whether the feasibility study's judgement of the suitability of the candidate area with respect to long-term safety holds up in the light of the actual site investigation data; to provide feedback to continued site investigations and site-specific repository design and to identify site-specific scenarios and geoscientific issues for further analyses. The PSE focuses on comparing the attained knowledge of the sites with the suitability criteria as set out by SKB. The PSE does not aim at comparing sites and does not assess compliance with safety and radiation protection criteria. The evaluation shows that, even considering remaining uncertainties, the Forsmark area meets all stated safety requirements and preferences. Consequently, from a safety point of view, there is no reason not to continue the Site Investigations of the Forsmark area. There are still uncertainties to resolve and the safety would eventually need to be verified through a full safety assessment. Nevertheless, this Preliminary Safety Evaluation demonstrates that it is likely that a safe repository for spent nuclear fuel of the KBS-3 type could be constructed at the site. The following feedback is provided to the site investigations and the associated site modelling: Reducing the uncertainty on the deformation zone geometry inside the target area would be needed to more firmly define locations of the suitable deposition volumes. There is substantial uncertainty in the Discrete Fracture Network model. Further reduction of the uncertainties, if needed, would probably only be possible from the underground, detailed investigation phase. Efforts need also be spent on improving the DFN-modelling. There are assumptions made in current models that could be challenged and there seems to be room for better use of the borehole information. It is particularly important to

  3. Brief narrative exposure therapy for posttraumatic stress in Iraqi refugees: a preliminary randomized clinical trial.

    Science.gov (United States)

    Hijazi, Alaa M; Lumley, Mark A; Ziadni, Maisa S; Haddad, Luay; Rapport, Lisa J; Arnetz, Bengt B

    2014-06-01

    Many Iraqi refugees suffer from posttraumatic stress. Efficient, culturally sensitive interventions are needed, and so we adapted narrative exposure therapy into a brief version (brief NET) and tested its effects in a sample of traumatized Iraqi refugees. Iraqi refugees in the United States reporting elevated posttraumatic stress (N = 63) were randomized to brief NET or waitlist control conditions in a 2:1 ratio; brief NET was 3 sessions, conducted individually, in Arabic. Positive indicators (posttraumatic growth and well-being) and symptoms (posttraumatic stress, depressive, and somatic) were assessed at baseline and 2- and 4-month follow-up. Treatment participation (95.1% completion) and study retention (98.4% provided follow-up data) were very high. Significant condition by time interactions showed that those receiving brief NET had greater posttraumatic growth (d = 0.83) and well-being (d = 0.54) through 4 months than controls. Brief NET reduced symptoms of posttraumatic stress (d = -0.48) and depression (d = -0.46) more, but only at 2 months; symptoms of controls also decreased from 2 to 4 months, eliminating condition differences at 4 months. Three sessions of brief NET increased growth and well-being and led to symptom reduction in highly traumatized Iraqi refugees. This preliminary study suggests that brief NET is both acceptable and potentially efficacious in traumatized Iraqi refugees.

  4. The persistence of and resistance to social norms regarding the appropriate amount to Eat: A preliminary investigation.

    Science.gov (United States)

    Feeney, Justin R; Pliner, Patricia; Polivy, Janet; Herman, C Peter

    2017-02-01

    We conducted a preliminary investigation on the resistance to, and persistence of, social influence regarding the appropriate amount to eat, defined in terms of eating an amount similar to that eaten by a confederate. Participants ate pizza both alone and in the presence of remote confederates presenting either a high or low eating norm. In the portion of the experiment examining resistance to social influence, participants given an initial opportunity to form a personal eating norm by eating alone for one session in the absence of social influence were no more resistant to low eating norms than were those who had no such opportunity; however, those who ate alone for two or three prior sessions did show resistance. For the high eating norm, it took three eating alone sessions to create resistance. In the portion of the experiment examining persistence of social influence, when participants ate alone following a session with norm-setting remote confederates, the effect of the social influence persisted. However, the persistence effect varied by norm and weakened over time. Participants modeled a low eating norm for only one additional session and the size of the effect was markedly weaker. By contrast, the high norm persisted for all of the remaining sessions. Thus, individuals' social influence histories can affect their eating. Copyright © 2016 Elsevier Ltd. All rights reserved.

  5. Development of a mobility and fuel strategy for Germany. Preliminary investigation; Entwicklung einer Mobilitaets- und Kraftstoffstrategie fuer Deutschland. Voruntersuchung

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-08-15

    Mobility is a key element in our society and often synonymous with traffic. It is desirable to secure a clean and diversified energy supply, to design a more sustainable transport structure and to minimize the burden on people and environment. This requires an updating of the fuel strategy 2004 and its progress toward a comprehensive mobility strategy and fuel strategy. Under this aspect, the contribution under consideration presents a preliminary investigation of the development of a mobility strategy and fuel strategy in Germany. Over the past ten years, the transport sector has reduced its energy consumption only slightly. The targets for the energy reduction now are -10 % up to 2020 and -40 % up to 2050. The transport sector challenges a significant contribution to the reduction of greenhouse gas emissions. In order to advance the necessary energy political as well as climate political changes the Federal Government wants to develop a comprehensive mobility strategy and fuel strategy. For this purpose, the contribution under consideration provides nine concrete recommendations for action for this.

  6. Preliminary investigation into the use of solar PV systems for residential application in Bandar Sri Iskandar, Malaysia

    Energy Technology Data Exchange (ETDEWEB)

    Dimas, F.A.; Gillani, S.I.; Ans, M.S. [Universiti Teknologi Petronas, Tronoh, Perak (Malaysia). Dept. of Mechanical Engineering

    2011-07-01

    In the near future, Malaysia is expected to be a net importer of oil, and the nation will have to face issues related to the security of supply and economic consequences. It is also anticipated that the energy demand for the country will increase with the increase in population and GDP. Realizing the situation, it is important that further emphasis is given into the diversification of energy resources. One method is the exploitation of renewable energy to minimize the effects of global warming. Photovoltaic technology is widely used around the world in locations with scarce power generation options. It is used for various applications and Building Integrated Photovoltaic (BIPV) system is one of them. However, photovoltaic is still expensive compared to conventional methods of generating electricity. So a careful design of the system is required to ensure economic viability. This study describes a preliminary investigation of a solar PV system for residential applications in Bandar Sri Iskandar. Sizing procedures based on the peak sun hour concept is described for a Malaysian typical terraced house. Current and voltage measurements of the solar panel were carried out to predict the output under actual conditions at the site.

  7. A Preliminary Empirical Investig ation of ‘Brick-to-Click’ Banking Presence in the United Arab Emirates

    Directory of Open Access Journals (Sweden)

    Bruce Budd

    2007-08-01

    Full Text Available This preliminary study undertakes to investigate the extent and quality of electronic banking (e-banking in UAE. Banks worldwide are now moving rapidly to an era of technological change. Online versions of ne arly all existing payment methods are appearing rapidly bringing about profound changes in the whole system of financial services and intermediation. While many banks especially in Europe and the U.S. have adopted internet banking, this research shows that the majority of banks in U.A.E. are still in the early stages of developing e-bank ing. Only 18 of the 46 banks in this emerging nation have well-developed e-banking facilicities, despite all banks having an internet banking website for the convenience of their customers. This study sets out to answer several important questions. Namely, what is e-banking? What services does e-banking provide in the UAE and what prov isions are made to improve customer relationship using this technology? Using a functionality-interactivity matrix cell model and a survey of 46 banks, evidence shows that the development of electronic ban king services within the UAE are moving closer towards western models, albeit, slowly. Evidence shows that reluctance of many banks to whole-heartedly brace e-banking is caused by security fears

  8. Preliminary investigation of a novel technique for the quantification of the ex vivo biomechanical properties of the vocal folds.

    Science.gov (United States)

    Coelho, Paulo G; Sobieraj, Michael; Tovar, Nick; Andrews, Kenneth; Paul, Benjamin; Govil, Nandini; Jeswani, Seema; Amin, Milan R; Janal, Malvin N; Branski, Ryan C

    2014-12-01

    The human vocal fold is a complex structure made up of distinct layers that vary in cellular and extracellular matrix composition. Elucidating the mechanical properties of vocal fold tissues is critical for the study of both acoustics and biomechanics of voice production, and essential in the context of vocal fold injury and repair. Both quasistatic and dynamic behavior in the 10-300 Hz range was explored in this preliminary investigation. The resultant properties of the lamina propria were compared to that of the nearby thyroarytenoid muscle. Er, quantified via quasistatic testing of the lamina propria, was 609±138 MPa and 758±142 MPa in the muscle (p=0.001). E' of the lamina propria as determined by dynamic testing was 790±526 MPa compared to 1061±928 MPa in the muscle. Differences in E' did not achieve statistical significance via linear mixed effect modeling between the tissue types (p=0.95). In addition, frequency dependence was not significant (p=0.18). Copyright © 2014 Elsevier B.V. All rights reserved.

  9. Synthesis and Preliminary Investigations of the siRNA Delivery Potential of Novel, Single-Chain Rigid Cationic Carotenoid Lipids

    Directory of Open Access Journals (Sweden)

    Philip L. Leopold

    2012-03-01

    Full Text Available The success of nucleic acid delivery requires the development of safe and efficient delivery vectors that overcome cellular barriers for effective transport. Herein we describe the synthesis of a series of novel, single-chain rigid cationic carotenoid lipids and a study of their preliminary in vitro siRNA delivery effectiveness and cellular toxicity. The efficiency of siRNA delivery by the single-chain lipid series was compared with that of known cationic lipid vectors, 3β-[N-(N',N'-dimethylaminoethanecarbamoyl]-cholesterol (DC-Chol and 1,2-dimyristoyl-sn-glyceryl-3-phosphoethanolamine (EPC as positive controls. All cationic lipids (controls and single-chain lipids were co-formulated into liposomes with the neutral co-lipid, 1,2-dioleolyl-sn-glycerol-3-phosphoethanolamine (DOPE. Cationic lipid-siRNA complexes of varying (+/− molar charge ratios were formulated for delivery into HR5-CL11 cells. Of the five single-chain carotenoid lipids investigated, lipids 1, 2, 3 and 5 displayed significant knockdown efficiency with HR5-CL11 cells. In addition, lipid 1 exhibited the lowest levels of cytotoxicity with cell viability greater than 80% at all (+/− molar charge ratios studied. This novel, single-chain rigid carotenoid-based cationic lipid represents a new class of transfection vector with excellent cell tolerance, accompanied with encouraging siRNA delivery efficiency.

  10. The impact of recovery-oriented day clinic treatment on internalized stigma: preliminary report.

    Science.gov (United States)

    Sibitz, Ingrid; Provaznikova, Katarina; Lipp, Madeleine; Lakeman, Richard; Amering, Michaela

    2013-10-30

    Internalized stigma is a complicating feature in the treatment of schizophrenia spectrum disorders and considerably hinders the recovery process. The empowerment and recovery-oriented program of our day clinic might contribute to a reduction in internalized stigma. The aim of the study was to explore the influence of this day clinic program on internalized stigma and other subjectively important outcome measures such as quality of life and psychopathology. Data from two groups of patients had been collected twice, at baseline and after 5 weeks. The experimental group attended the day clinic treatment (N=40) and the control group waited for the day clinic treatment (N=40). The following significant differences between the two groups were found: Patients in day clinic treatment showed a reduction in internalized stigma while the control group showed a minimal increase (Cohen's d=0.446). The experimental group as compared with the control group also showed a greater improvement in the quality of life domain psychological health (Cohen's d=0.6) and in overall psychopathology (Cohen's d=0.452). Interestingly, changes in internalized stigma and psychological quality of life were not associated with changes in psychopathology. Results are encouraging but have to be confirmed in a randomized design. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  11. Sample sizes in dosage investigational clinical trials: a systematic evaluation

    OpenAIRE

    Huang JH; Su QM; Yang J; Lv YH; He YC; Chen JC; Xu L; Wang K; Zheng QS

    2015-01-01

    Ji-Han Huang,1,* Qian-Min Su,2,* Juan Yang,1 Ying-Hua Lv,1 Ying-Chun He,1 Jun-Chao Chen,1 Ling Xu,1 Kun Wang,1 Qing-Shan Zheng11Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 2Department of Computer, College of Electronic and Electrical Engineering, Shanghai University of Engineering Science, Shanghai, People’s Republic of China *These authors contributed equally to this workAbstract: T...

  12. Survey of integrative lumbar spinal stenosis treatment in Korean medicine doctors: preliminary data for clinical practice guidelines.

    Science.gov (United States)

    Lee, Yoon Jae; Shin, Joon-Shik; Lee, Jinho; Kim, Me-Riong; Ahn, Yong-Jun; Shin, Ye-Sle; Park, Ki Byung; Shin, Byung-Cheul; Lee, Myeong Soo; Kim, Joo-Hee; Cho, Jae-Heung; Ha, In-Hyuk

    2017-08-29

    Considering that large variations exist amongst practitioners in lumbar disorder management and the significant costs that lumbar disorders incur, determining clinical practice patterns to provide preliminary data for standardization should be given higher priority. Lumbar spinal stenosis (LSS) is commonly treated using integrative non-surgical methods by Korean medicine doctors (KMDs) in Korea, and this is the first study to assess current Korean medicine practice trends for LSS. A survey on KMD diagnosis, treatment, prognosis and decision-making in LSS treatment was developed in a 3-step procedure of preliminary drafting, revision based on extramural expert opinion, and final editing. The survey was conducted at the internal conference of a spine-specialty Korean medicine hospital on January 25th, 2015. The response rate was high at 79.19% (n = 118/149). Participants replied that they treated 7.3 ± 6.8 LSS patients/day using a multimodal treatment method consisting of acupuncture, pharmacopuncture, herbal medicine, Chuna manipulation, and electroacupuncture. Acupuncture mainly used Ashi points and MSAT, and pharmacopuncture mainly Shinbaro solution. The most frequently prescribed herbal medicine was Chungpa-jun, and the most commonly applied Chuna techniques were sidelying lumbar extension dysfunction correction technique, and prone lumbosacral joint distraction method. Radiological findings were mainly referred to for diagnosis, and clinical symptoms, age, radiological findings, and medical history were regarded to be important for prognosis. Participants replied that 7.8 ± 3.3 weeks were required for 50% reduction in pain, and 16.1 ± 7.7 weeks for 80% reduction. These results suggest that KMDs in Korea combine a conventional approach to LSS and a Korean medicine approach to low back pain for integration of empirical- and evidence-based diagnosis and treatment. The findings may contribute in bridging the divide between evidence and clinical practice

  13. SOME THEORETICAL ASPECTS OF COMPLEX CLINICAL-PSYCHOLOGICAL INVESTIGATION OF PATIENTS WITH AUTOIMMUNE LIVER DISEASES IN CIRRHOTIC STAGE BEFORE LIVER TRANSPLANTATION

    Directory of Open Access Journals (Sweden)

    O. A. Gerasimova

    2010-01-01

    Full Text Available This article presents preliminary results of complex clinical-psychological investigation of patients with autoim- mune liver diseases with cirrhosis waiting for liver transplant. The data discussed defense role of anxiety com- bined with other emotional affective disorders, psychological mechanisms in combination with coping strategies of stress-overcoming behavior in the state of disease and their involvement in formation of the clinical picture of the disease. It considers the need for differential diagnosis of the pathology using modern experimental- psychological methods in connection with further building of psychological aid to patients with autoimmune liver diseases. 

  14. Clinical effects of an avocado-soybean unsaponifiable extract on arthralgia and osteoarthritis of the temporomandibular joint: preliminary study.

    Science.gov (United States)

    Catunda, I S; Vasconcelos, B C do E; Andrade, E S de S; Costa, D F N

    2016-08-01

    The aim of the present preliminary study was to investigate the effectiveness of an avocado-soybean unsaponifiable extract (ASU) in patients with arthralgia and osteoarthritis of the temporomandibular joint (TMJ). A randomized, double-blind, placebo-controlled trial was carried out. Fourteen women diagnosed with arthralgia and osteoarthritis of the TMJ using the Research Diagnostic Criteria for Temporomandibular Disorders were included in the statistical analysis. The women were allocated randomly to two groups: ASU group and placebo group. Pain was measured using a visual analogue scale and pressure algometer. Mandibular function was evaluated through measurement of mandibular movements. Quality of life was measured using the Oral Health Impact Profile (OHIP-14). The medication (ASU capsules or placebo capsules) was used for 4 months and the total follow-up was 6 months. Those taking the ASU extract had a decrease in pain symptoms and an improvement in quality of life. Moreover, a significant reduction in the use of rescue medication was found in the ASU group compared to the placebo group. This preliminary study provides strong evidence of the effectiveness of an avocado-soybean unsaponifiable extract in patients with degenerative joint diseases and arthralgia in the TMJ. Further studies with larger samples should be performed.

  15. Clinical value of isotope methods in adrenal morphology investigations

    Energy Technology Data Exchange (ETDEWEB)

    Jakubowski, W.; Feltynowski, T.; Graban, W. (Akademia Medyczna, Warsaw (Poland))

    1981-01-01

    In the years 1976-1980 in 105 patients 124 adrenal scintigrams were obtained, including 50 in patients with primary hyperaldosteronism syndrome, 27 with Cushings syndrome, 8 after bilateral total adrenalectomy, 4 with adrenal virilizing tumours, 6 with phaeochromocytoma, 10 with normal adrenal function. The results of scintigraphy were compared with those of arteriography, phlebography, computer tomography and postoperative findings. The clinical value of scintigraphy was found to be greatest in cases of adrenocortical disease. In cases of phaeochromocytoma isotope angioscintigraphy is a useful method for localizing the tumour since it makes possible demonstration of the vascular bed of the tumour. A close correlation was demonstrated between the results of scintigraphy and those of computer tomography. In the group of 27 patients treated surgically for adrenocortical disease in 87% of cases an agreement was found between the results of scintigraphy and the result of the operation. For different adrenocortical diseases this per cent was: 77% for Cushings syndrome, 91% for primary hyperaldosteronism, 100% for adrenal virilizing tumours. The study showed that adrenal scintigraphy is a very valuable diagnostic method of high clinical usefulness in adrenocortical diseases.

  16. 78 FR 60291 - Investigational Device Exemptions for Early Feasibility Medical Device Clinical Studies...

    Science.gov (United States)

    2013-10-01

    ... ``Investigational Device Exemptions (IDEs) for Early Feasibility Medical Device Clinical Studies, Including Certain... facilitate early feasibility studies of medical devices, using appropriate risk mitigation strategies, under the IDE regulations. Early feasibility studies allow for limited early clinical evaluations of...

  17. 21 CFR 812.119 - Disqualification of a clinical investigator.

    Science.gov (United States)

    2010-04-01

    ..., the Center for Biologics Evaluation and Research, or the Center for Drug Evaluation and Research will... submitted unreliable data that are essential to the continuation of the investigation or essential to the approval or clearance of any marketing application. (d) If the Commissioner determines, after...

  18. Malignant mesothelioma, clinical, diagnostic and cell biological investigations

    NARCIS (Netherlands)

    M.A. Versnel (Marjan)

    1989-01-01

    textabstractThe purpose of this study was to improve the diagnosis of human malignant mesothelioma on the one hand and to investigate the growth regulation and transformation of normal and malignant mesothelial cells on the other hand. In this thesis improvement of diagnosis was approached by the se

  19. N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Preliminary Clinical and Cell Line Data.

    Directory of Open Access Journals (Sweden)

    Daniel A Monti

    Full Text Available The purpose of this study was to assess the biological and clinical effects of n-acetyl-cysteine (NAC in Parkinson's disease (PD.The overarching goal of this pilot study was to generate additional data about potentially protective properties of NAC in PD, using an in vitro and in vivo approach. In preparation for the clinical study we performed a cell tissue culture study with human embryonic stem cell (hESC-derived midbrain dopamine (mDA neurons that were treated with rotenone as a model for PD. The primary outcome in the cell tissue cultures was the number of cells that survived the insult with the neurotoxin rotenone. In the clinical study, patients continued their standard of care and were randomized to receive either daily NAC or were a waitlist control. Patients were evaluated before and after 3 months of receiving the NAC with DaTscan to measure dopamine transporter (DAT binding and the Unified Parkinson's Disease Rating Scale (UPDRS to measure clinical symptoms.The cell line study showed that NAC exposure resulted in significantly more mDA neurons surviving after exposure to rotenone compared to no NAC, consistent with the protective effects of NAC previously observed. The clinical study showed significantly increased DAT binding in the caudate and putamen (mean increase ranging from 4.4% to 7.8%; p<0.05 for all values in the PD group treated with NAC, and no measurable changes in the control group. UPDRS scores were also significantly improved in the NAC group (mean improvement of 12.9%, p = 0.01.The results of this preliminary study demonstrate for the first time a potential direct effect of NAC on the dopamine system in PD patients, and this observation may be associated with positive clinical effects. A large-scale clinical trial to test the therapeutic efficacy of NAC in this population and to better elucidate the mechanism of action is warranted.ClinicalTrials.gov NCT02445651.

  20. Preliminary geologic investigation of the Apollo 12 landing site: Part A: Geology of the Apollo 12 Landing Site

    Science.gov (United States)

    Shoemaker, E.M.; Batson, R.M.; Bean, A.L.; Conrad, C.; Dahlem, D.H.; Goddard, E.N.; Hait, M.H.; Larson, K.B.; Schaber, G.G.; Schleicher, D.L.; Sutton, R.L.; Swann, G.A.; Waters, A.C.

    1970-01-01

    This report provides a preliminary description of the geologic setting of the lunar samples returned fromt he Apollo 12 mission. A more complete interpretation of the geology of the site will be prepared after thorough analysis of the data.

  1. Preliminary pharmacological investigation of the ischuretic property and safety of a hydro-ethanolic extract of Amaranthus spinosis (Fam: Amaranthaceae

    Directory of Open Access Journals (Sweden)

    George A. Koffuor

    2013-10-01

    Full Text Available Background: Ischuria is a health and social problem, having a negative impact on sufferers. This study therefore was a preliminary investigation of the ischuretic property and safety for use of a hydro-ethanolic extract of Amaranthus spinosus used traditionally in managing ischuria. Methods: Phytochemical screening, thin layer chromatography and high performance liquid chromatography were performed on the extract to establish fingerprints for identification. Acetylcholine, Nicotine, and the extract were applied to an isolated rat urinary bladder to ascertain contractile response. The possible receptor site(s of action was also investigated using isolated rabbit jejunum, and guinea-pig ileum preparations. In-house observation, hematological analysis, and liver and kidney function tests were performed on Sprague-Dawley rats, in acute and sub-acute toxicity studies. Results: The extract had contractile effects on the rat urinary bladder (similar to acetylcholine and nicotine and rabbit jejunum. Its contractile effect of the guinea-pig ileum was significantly inhibited by hexamethonium (77.50 ± 8.50 %; P ≤ 0.001 and to a lesser extent by mepyramine (49.2 ± 6.80 %; P ≤ 0.001 and Atropine (22.45 ± 5.22 %; P ≤ 0.01. The extract (80-800 mg kg-1 was not lethal and a 160 and 240 mg kg-1 dose had no adverse effect on blood, liver, kidney metabolic function. Conclusions: The hydro-ethanolic extract of Amaranthus spinosus has ischuretic activity possibly mediated via nicotinic, histaminic and muscarinic receptor stimulation and is safety to use in ischuria. [Int J Basic Clin Pharmacol 2013; 2(5.000: 517-527

  2. MR coronary angiography with breath-hold targeted volumes: preliminary clinical results

    NARCIS (Netherlands)

    R.J.M. van Geuns (Robert Jan); P.A. Wielopolski (Piotr); H.G. de Bruin (Hein); B.J.W.M. Rensing (Benno); M. Hulshoff (Maarten); P.M.A. van Ooijen (Peter); P.J. de Feyter (Pim); M. Oudkerk (Matthijs)

    2000-01-01

    textabstractPURPOSE: To assess the clinical value of a magnetic resonance (MR) coronary angiography strategy involving a small targeted volume to image one coronary segment in a single breath hold for the detection of greater than 50% stenosis. MATERIALS AND METHODS:

  3. MR coronary angiography with breath-hold targeted volumes : Preliminary clinical results

    NARCIS (Netherlands)

    van Geuns, R J; Wielopolski, P A; de Bruin, Hein G.; Rensing, B J; Hulshoff, Marc; van Ooijen, P M; de Feyter, P J; Oudkerk, M

    2000-01-01

    PURPOSE: To assess the clinical value of a magnetic resonance (MR) coronary angiography strategy involving a small targeted volume to image one coronary segment in a single breath hold for the detection of greater than 50% stenosis. MATERIALS AND METHODS: Thirty-eight patients referred for elective

  4. Clinical investigations of receptive and expressive musical functions after stroke

    OpenAIRE

    Ken eRosslau; Daniel eSteinwede; Christine eSchröder; Sibylle eHerholz; Claudia eLappe; Christian eDobel; Eckart eAltenmüller

    2015-01-01

    There is a long tradition of investigating various disorders of musical abilities after stroke. These impairments, associated with acquired amusia, can be highly selective, affecting only music perception (i.e., receptive abilities/functions) or expression (music production abilities), and some patients report that these may dramatically influence their emotional state. The aim of this study was to systematically test both the melodic and rhythmic domains of music perception and expression in...

  5. Preliminary comparison of the Essie and PubMed search engines for answering clinical questions using MD on Tap, a PDA-based program for accessing biomedical literature.

    Science.gov (United States)

    Sutton, Victoria R; Hauser, Susan E

    2005-01-01

    MD on Tap, a PDA application that searches and retrieves biomedical literature, is specifically designed for use by mobile healthcare professionals. With the goal of improving the usability of the application, a preliminary comparison was made of two search engines (PubMed and Essie) to determine which provided most efficient path to the desired clinically-relevant information.

  6. Preliminary report on management of neonatal jaundice in maternity clinics of São Paulo city, Brazil

    Directory of Open Access Journals (Sweden)

    Fernando Bastos

    2007-03-01

    Full Text Available Objective: The treatment of neonatal hyperbilirubinemia remains aproblem because it can lead to sequelae in both children and adults. Theobjective of this study was to evaluate how neonatal jaundice is treatedin maternity hospitals in the city of São Paulo. Methods: Prospective andtransversal study on maternity hospitals in the city of São Paulo, Brazil. Aquestionnaire was applied to doctors working at neonatal wards withinmaternity hospitals in the city of São Paulo, divided into public (n = 6 andprivate maternity clinics (n = 18. The results obtained from the differentitems of the questionnaire were then compared. Statistical analysis wasperformed using the Student’s t test, chi-square test and Mann-Whitneytest when appropriate, and a p value < 0.005 was considered significant.Results: There were no significant differences between the two typesof maternity hospitals in relation to the treatment method for neonataljaundice. However, among private maternities there were some that didnot have written guidelines (5/17 and those that performed exchangetransfusion (3/18. Teaching was significantly more present amongpublic (100% than private maternity hospitals (17.6%. The mean serumbilirubin levels to initiate treatment did not show significant differencesbetween the two types of maternities. Some clinical practices in use bymaternity hospitals are not evidence based. Conclusions: The presentdata were considered preliminary and showed that further research inthe area is required and if our findings are confirmed, indicate the needfor continuous medical education on the part of health professionals incharge of newborns.

  7. Design, Implementation, Use, and Preliminary Evaluation of SEBASTIAN, a Standards-Based Web Service for Clinical Decision Support

    Science.gov (United States)

    Kawamoto, Kensaku; Lobach, David F.

    2005-01-01

    Despite their demonstrated ability to improve care quality, clinical decision support systems are not widely used. In part, this limited use is due to the difficulty of sharing medical knowledge in a machine-executable format. To address this problem, we developed a decision support Web service known as SEBASTIAN. In SEBASTIAN, individual knowledge modules define the data requirements for assessing a patient, the conclusions that can be drawn using that data, and instructions on how to generate those conclusions. Using standards-based XML messages transmitted over HTTP, client decision support applications provide patient data to SEBASTIAN and receive patient-specific assessments and recommendations. SEBASTIAN has been used to implement four distinct decision support systems; an architectural overview is provided for one of these systems. Preliminary assessments indicate that SEBASTIAN fulfills all original design objectives, including the re-use of executable medical knowledge across diverse applications and care settings, the straightforward authoring of knowledge modules, and use of the framework to implement decision support applications with significant clinical utility. PMID:16779066

  8. The clinical significance of brain microbleeds in patients with Alzheimer′s disease: Preliminary study

    Directory of Open Access Journals (Sweden)

    Jae-Hyeok Heo

    2016-01-01

    Full Text Available Background: Microbleeds (MBs are observed frequently in Alzheimer′s disease (AD and suggested to play a crucial role in the pathophysiology, but their clinical significance remains unclear. Materials and Methods: The study recruited 100 patients with AD who were diagnosed at the memory clinic in Seoul Medical Center in 2014. For each patient, baseline characteristics, neuropsychological tests, cerebrovascular risk factors, medial temporal lobe atrophy (MTLA, and severity of small vessel disease (SVD according to the existence of MBs were evaluated. Results: The prevalence of MBs in patients with AD was 33%. The percentage of male gender, the severity of SVD and MTLA were significantly increased in MB(+ group. The MB(+ group showed more severe MTLA and SVD than MB(− group. Conclusions: These results suggested that MBs might reflect the burden of amyloid and ischemic vascular pathology.

  9. A preliminary clinical evaluation of external snehan and asanas in the patients of sciatica

    OpenAIRE

    Singh, Akhilesh K.; Singh, Om P.

    2013-01-01

    Lower back pain radiating to either on one leg or both legs along the course of sciatic nerve is a common ailment in the clinical practice, this type of peculiar symptomatology is termed as "Sciatica" in modern medicine. The medical treatment is unsatisfactory for both the patient and the neurosurgeons, as the surgical treatment has its own hazards and the cost of the surgical procedure and medical treatment is prohibitory to most of the Indian patients. Hence, most of the patients present th...

  10. A preliminary analysis of microRNA as potential clinical biomarker for schizophrenia.

    Science.gov (United States)

    Sun, Xin-yang; Zhang, Jin; Niu, Wei; Guo, Wei; Song, Hong-tao; Li, Heng-yu; Fan, Hui-min; Zhao, Lin; Zhong, Ai-fang; Dai, Yun-hua; Guo, Zhong-min; Zhang, Li-yi; Lu, Jim; Zhang, Qiao-li

    2015-04-01

    MicroRNAs (miRNA, miR) have been implicated as promising blood-based biomarkers for schizophrenia patients. This study aimed to clinically validate miRNA as potential schizophrenia biomarkers. Plasma levels of 10 miRNAs were analyzed using qPCR in a cohort of 61 schizophrenia patients and 62 normal controls, as well as 25 patients particularly selected for a six-week antipsychotic treatment course. Positive And Negative Syndrome Scale (PANSS), Global Assessment Scale (GAS) and Clinical Global Impression (CGI) were administered to assess the clinical symptoms. The results demonstrated that a panel of miRNAs consisting of miR-30e, miR-181b, miR-34a, miR-346 and miR-7 had significantly increased expression levels with significant combined diagnostic value (AUC:0.713; sensitivity:35.5%; specificity:90.2%). In response to pharmacological treatment, expression levels of miR-132, miR-181b, miR-432 and miR-30e were significantly decreased. In addition, the improvement of clinical symptomatology was significantly correlated with the changes of miR-132, miR-181b, miR-212 and miR-30e expression levels. Furthermore, the decreases of plasma levels of miR-132 and miR-432 were significantly greater in high-effect subgroup than those in low-effect subgroup after six-week treatment course. We conclude that miR-30e, miR-181b, miR-34a, miR-346 and miR-7 combined as a panel are potentially useful non-invasive biomarkers for schizophrenia diagnosis. Markers miR-132, miR-181b, miR-30e and miR-432 are potential indicators for symptomatology improvements, treatment responses and prognosis for schizophrenia patients.

  11. Clinical investigation of risk factors in ectopic pregnancy

    Directory of Open Access Journals (Sweden)

    Ling-yun HU

    2013-05-01

    Full Text Available Objective  To discuss the relative and independent risk factors in ectopic pregnancy. Methods  The clinical data of 870 patients with ectopic pregnancy, admitted from 2005 to 2012, were retrospectively analyzed, with 800 cases of normal pregnancy serving as control. Monofactorial correlation analysis was used to analyze the related risk factor, and logistic regression analysis was used to analyze the independent risk factor. Results  Pelvic adhesion, previous operation, cesarean section delivery, number of pregnancy, artificial abortion, medical abortion, in vitrofertilization and embryo replacement (IVF-ER, and placement of intrauterine device (IUD are the risk factors of ectopic pregnancy, pelvic adhesion, artificial abortion, operation, number of pregnancies and IUD are the independent risk factors, and pelvic adhesion is the major risk factor. Conclusion  Avoidance of unexpected pregnancy as possible, reduction of the number of artificial abortion, prevention and treatment of genital duct inflammation, and standardization of pelvic operation may reduce the incidence of ectopic pregnancy.

  12. Investigation of Tinnitus Patients in Italy: Clinical and Audiological Characteristics

    Directory of Open Access Journals (Sweden)

    Francesco Martines

    2010-01-01

    Full Text Available Objective. 312 tinnitus sufferers were studied in order to analyze: the clinical characteristics of tinnitus; the presence of tinnitus-age correlation and tinnitus-hearing loss correlation; the impact of tinnitus on subjects' life and where possible the etiological/predisposing factors of tinnitus. Results. There is a slight predominance of males. The highest percentage of tinnitus results in the decades 61–70. Of the tinnitus sufferers, 197 (63.14% have a hearing deficit (light hearing loss in 37.18% of cases. The hearing impairment results of sensorineural type in 74.62% and limited to the high frequencies in 58.50%. The tinnitus is referred as unilateral in 59.93%, a pure tone in 66.99% and 10 dB above the hearing threshold in 37.7%. It is limited to high frequencies in 72.10% of the patients with sensorineural hearing loss (SNHL while the 88.37% of the patients with high-frequency SNHL have a high-pitched tinnitus (2=66.26;<.005. Conclusion. Hearing status and age represent the principal tinnitus related factors; there is a statistically significant association between high-pitched tinnitus and high-frequency SNHL. There is no significant correlation between tinnitus severity and tinnitus loudness confirming the possibility that neural connection involved in evoking tinnitus-related negative reactions are governed by conditioned reflexes.

  13. Hyperacuity test to evaluate vision through dense cataracts: research preliminary to a clinical study in India

    Science.gov (United States)

    Enoch, Jay M.; Giraldez, Maria J.; Huang, Doahua; Hirose, Hiroshi; Knowles, Richard A.; Namperumalsamy, P.; LaBree, Lauri; Azen, Stanley P.

    1995-03-01

    Using high luminance point-of-light stimuli, Vernier judgments can be made in the presence of markedly degraded retinal imagery. Without coaching, observers perform center-of-gravity assessments of relative locations of degraded point images. We seek to defined, presurgery, individuals who will derive the most benefit from advanced cataract removal (a form of triage), and to determine which of two cataractous eyes has the better postsurgical visual prognosis. There are incredible and growing backlogs of patients with severe cataracts (and other dense media opacities) in the developing world, and generally, limited resources are available for provision of health care. Postcataract surgical failure rates for good visual function are often high, and only one eye is operated on in over 95% of indigent patients treated. Prior to initiating advanced studies in the developing world, at Berkeley we conducted preliminary research on Vernier acuity test techniques on normal adult subjects. We sought to determine the number of repeat trials necessary; to compare a two-point and a three-point Vernier display; to determine the shape of the measured response function at large gap separations between test points (required when testing advanced cataract patients); to assess the effect(s) of a broad range of uncorrected refractive errors on outcomes; and to consider means to minimize refraction-based errors. From these and prior data and analyses, we defined a protocol for use in the developing world. Using a newly designed and rugged precision instrument, these tests were repeated on an advanced cataract population at Aravind Eye Hospital in Madurai, India. Although we had much prior experience in India, the initial protocol required major revision on site. Necessary changes in test methods and analytical approaches were made, and next stages in this program were planned. And a new and simple gap `visual acuity' (gap `VA') test was added to the protocol, which greatly facilitated

  14. Clinical investigations of receptive and expressive musical functions after stroke

    Directory of Open Access Journals (Sweden)

    Ken eRosslau

    2015-06-01

    Full Text Available There is a long tradition of investigating various disorders of musical abilities after stroke. These impairments, associated with acquired amusia, can be highly selective, affecting only music perception (i.e., receptive abilities/functions or expression (music production abilities, and some patients report that these may dramatically influence their emotional state. The aim of this study was to systematically test both the melodic and rhythmic domains of music perception and expression in left- and right-sided stroke patients compared to healthy subjects. Music perception was assessed using rhythmic and melodic discrimination tasks, while tests of expressive function involved the vocal or instrumental reproduction of rhythms and melodies. Our approach revealed deficits in receptive and expressive functions in stroke patients, mediated by musical expertise. Those patients who had experienced a short period of musical training in childhood and adolescence performed better in the receptive and expressive subtests compared to those without any previous musical training. While discrimination of specific musical patterns was unimpaired after a right-sided stroke, patients with a left-sided stroke had worse results for fine melodic and rhythmic analysis. In terms of expressive testing, the most consistent results were obtained from a test that required patients to reproduce sung melodies. This implies that the means of investigating production abilities can impact the identification of deficits.

  15. Clinical investigations of receptive and expressive musical functions after stroke.

    Science.gov (United States)

    Rosslau, Ken; Steinwede, Daniel; Schröder, C; Herholz, Sibylle C; Lappe, Claudia; Dobel, Christian; Altenmüller, Eckart

    2015-01-01

    There is a long tradition of investigating various disorders of musical abilities after stroke. These impairments, associated with acquired amusia, can be highly selective, affecting only music perception (i.e., receptive abilities/functions) or expression (music production abilities), and some patients report that these may dramatically influence their emotional state. The aim of this study was to systematically test both the melodic and rhythmic domains of music perception and expression in left- and right-sided stroke patients compared to healthy subjects. Music perception was assessed using rhythmic and melodic discrimination tasks, while tests of expressive function involved the vocal or instrumental reproduction of rhythms and melodies. Our approach revealed deficits in receptive and expressive functions in stroke patients, mediated by musical expertise. Those patients who had experienced a short period of musical training in childhood and adolescence performed better in the receptive and expressive subtests compared to those without any previous musical training. While discrimination of specific musical patterns was unimpaired after a left-sided stroke, patients with a right-sided stroke had worse results for fine melodic and rhythmic analysis. In terms of expressive testing, the most consistent results were obtained from a test that required patients to reproduce sung melodies. This implies that the means of investigating production abilities can impact the identification of deficits.

  16. Preliminary investigation of the effects of sea-level rise on groundwater levels in New Haven, Connecticut

    Science.gov (United States)

    Bjerklie, David M.; Mullaney, John R.; Stone, Janet R.; Skinner, Brian J.; Ramlow, Matthew A.

    2012-01-01

    New Haven area and from new information on groundwater levels collected during October 2009-June 2010. For the scenario with a 3-ft rise in sea level and no increase in recharge, simulated groundwater levels near the coast rose 3 ft; this increased water level tapered off toward a discharge area at the only nontidal stream in the study area. Simulated stream discharge increased at the nontidal stream because of the increased gradient. Although groundwater levels rose, the simulated difference between the groundwater levels in the aquifer and the increased sea level declined, indicating that the depth to the interface between freshwater and saltwater may possibly decline. Simulated water levels were affected by rise in sea level even in areas where the water table was at 17-24 ft (5.2-7.3 m) above current (2011) sea level. For the scenario with increased recharge, simulated groundwater levels were as much as an additional foot higher at some locations in the study area. The results of this preliminary investigation indicate that groundwater levels in coastal areas can be expected to rise and may rise higher if groundwater recharge also increases. This finding has implications for the disposal of stormwater through infiltration, a low-impact development practice designed to improve water quality and reduce overland peak discharge. Other implications include increased risk of basement flooding and increased groundwater seepage into underground sewer pipes and utility corridors in some areas. These implications will present engineering challenges to New Haven and Yale University. The preliminary model developed for this study can be the starting point for further simulation of future alternative scenarios for sea-level rise and recharge. Further simulations could identify those areas of New Haven where infrastructure may be at greatest risk from rising levels of groundwater. The simulations described in this report have limitations due to the preliminary scope of the work

  17. Preliminary Results From the CAUGHT Experiment: Investigation of the North Central Andes Subsurface Using Receiver Functions and Ambient Noise Tomography

    Science.gov (United States)

    Ryan, J. C.; Ward, K. M.; Porter, R. C.; Beck, S. L.; Zandt, G.; Wagner, L. S.; Minaya, E.; Tavera, H.

    2011-12-01

    Jamie Ryan, Kevin M. Ward, Ryan Porter, Susan Beck, George Zandt, Lara Wagner, Estela Minaya, and Hernando Tavera The University of Arizona The University of North Carolina San Calixto Observatorio, La Paz, Bolivia IGP, Lima, Peru In order to investigate the interplay between crustal shortening, lithospheric removal, and surface uplift we have deployed 50 broadband seismometers in northwestern Bolivia and southern Peru as part of the interdisciplinary Central Andean Uplift and Geodynamics of High Topography (CAUGHT) project. The morphotectonic units of the central Andes from west to east, consist of the Western Cordillera, the active volcanic arc, the Altiplano, an internally drained basin (~4 km elevation), the Eastern Cordillera, the high peaks (~6 km elevation) of an older fold and thrust belt, the Subandean zone, the lower elevation active fold and thrust belt, and the foreland Beni basin. Between northwestern Bolivia and southern Peru, the Altiplano pinches out north of Lake Titicaca as the Andes narrow northward. The CAUGHT seismic instruments were deployed between 13° to 18° S latitudes to investigate the crust and mantle lithosphere of the central Andes in this transitional zone. In northwest Bolivia, perpendicular to the strike of the Andes, there is a total of 275 km of documented upper crustal shortening (15° to 17°S) (McQuarrie et al, 2008). Associated with the shortening is crustal thickening and possibly lithospheric removal as the thickening lithospheric root becomes unstable. An important first order study is to compare upper crustal shortening estimates with present day crustal thickness. To estimate crustal thickness, we have calculated receiver functions using an iterative deconvolution method and used common conversion point stacking along the same profile as the geologically based shortening estimates. In our preliminary results, we observed a strong P to S conversion corresponding to the Moho at approximately 60-65 km depth underneath the

  18. Delayed P100-Like Latencies in Multiple Sclerosis: A Preliminary Investigation Using Visual Evoked Spread Spectrum Analysis.

    Directory of Open Access Journals (Sweden)

    Hanni S M Kiiski

    Full Text Available Conduction along the optic nerve is often slowed in multiple sclerosis (MS. This is typically assessed by measuring the latency of the P100 component of the Visual Evoked Potential (VEP using electroencephalography. The Visual Evoked Spread Spectrum Analysis (VESPA method, which involves modulating the contrast of a continuous visual stimulus over time, can produce a visually evoked response analogous to the P100 but with a higher signal-to-noise ratio and potentially higher sensitivity to individual differences in comparison to the VEP. The main objective of the study was to conduct a preliminary investigation into the utility of the VESPA method for probing and monitoring visual dysfunction in multiple sclerosis. The latencies and amplitudes of the P100-like VESPA component were compared between healthy controls and multiple sclerosis patients, and multiple sclerosis subgroups. The P100-like VESPA component activations were examined at baseline and over a 3-year period. The study included 43 multiple sclerosis patients (23 relapsing-remitting MS, 20 secondary-progressive MS and 42 healthy controls who completed the VESPA at baseline. The follow-up sessions were conducted 12 months after baseline with 24 MS patients (15 relapsing-remitting MS, 9 secondary-progressive MS and 23 controls, and again at 24 months post-baseline with 19 MS patients (13 relapsing-remitting MS, 6 secondary-progressive MS and 14 controls. The results showed P100-like VESPA latencies to be delayed in multiple sclerosis compared to healthy controls over the 24-month period. Secondary-progressive MS patients had most pronounced delay in P100-like VESPA latency relative to relapsing-remitting MS and controls. There were no longitudinal P100-like VESPA response differences. These findings suggest that the VESPA method is a reproducible electrophysiological method that may have potential utility in the assessment of visual dysfunction in multiple sclerosis.

  19. Delayed P100-Like Latencies in Multiple Sclerosis: A Preliminary Investigation Using Visual Evoked Spread Spectrum Analysis

    Science.gov (United States)

    Kiiski, Hanni S. M.; Ní Riada, Sinéad; Lalor, Edmund C.; Gonçalves, Nuno R.; Nolan, Hugh; Whelan, Robert; Lonergan, Róisín; Kelly, Siobhán; O'Brien, Marie Claire; Kinsella, Katie; Bramham, Jessica; Burke, Teresa; Ó Donnchadha, Seán; Hutchinson, Michael; Tubridy, Niall; Reilly, Richard B.

    2016-01-01

    Conduction along the optic nerve is often slowed in multiple sclerosis (MS). This is typically assessed by measuring the latency of the P100 component of the Visual Evoked Potential (VEP) using electroencephalography. The Visual Evoked Spread Spectrum Analysis (VESPA) method, which involves modulating the contrast of a continuous visual stimulus over time, can produce a visually evoked response analogous to the P100 but with a higher signal-to-noise ratio and potentially higher sensitivity to individual differences in comparison to the VEP. The main objective of the study was to conduct a preliminary investigation into the utility of the VESPA method for probing and monitoring visual dysfunction in multiple sclerosis. The latencies and amplitudes of the P100-like VESPA component were compared between healthy controls and multiple sclerosis patients, and multiple sclerosis subgroups. The P100-like VESPA component activations were examined at baseline and over a 3-year period. The study included 43 multiple sclerosis patients (23 relapsing-remitting MS, 20 secondary-progressive MS) and 42 healthy controls who completed the VESPA at baseline. The follow-up sessions were conducted 12 months after baseline with 24 MS patients (15 relapsing-remitting MS, 9 secondary-progressive MS) and 23 controls, and again at 24 months post-baseline with 19 MS patients (13 relapsing-remitting MS, 6 secondary-progressive MS) and 14 controls. The results showed P100-like VESPA latencies to be delayed in multiple sclerosis compared to healthy controls over the 24-month period. Secondary-progressive MS patients had most pronounced delay in P100-like VESPA latency relative to relapsing-remitting MS and controls. There were no longitudinal P100-like VESPA response differences. These findings suggest that the VESPA method is a reproducible electrophysiological method that may have potential utility in the assessment of visual dysfunction in multiple sclerosis. PMID:26726800

  20. Comparison of effects of uncomplicated canine babesiosis and canine normovolaemic anaemia on abdominal splanchnic Doppler characteristics - a preliminary investigation

    Directory of Open Access Journals (Sweden)

    L.M. Koma

    2005-06-01

    Full Text Available A preliminary study was conducted to compare uncomplicated canine babesiosis (CB and experimentally induced normovolaemic anaemia (EA using Doppler ultrasonography of abdominal splanchnic vessels. Fourteen dogs with uncomplicated CB were investigated together with 11 healthy Beagles during severe EA, moderate EA and the physiological state as a control group. Canine babesiosis was compared with severe EA, moderate EA and the physiological state using Doppler variables of the abdominal aorta, cranial mesenteric artery (CMA, coeliac, left renal and interlobar, and hilar splenic arteries, and the main portal vein. Patterns of haemodynamic changes during CB and EA were broadly similar and were characterised by elevations in velocities and reductions in resistance indices in all vessels except the renal arteries when compared with the physiological state. Aortic and CMA peak systolic velocities and CMA end diastolic and time-averaged mean velocities in CB were significantly lower (P < 0.023 than those in severe EA. Patterns of renal haemodynamic changes during CB and EA were similar. However, the renal patterns differed from those of aortic and gastrointestinal arteries, having elevations in vascular resistance indices, a reduction in end diastolic velocity and unchanged time-averaged mean velocity. The left renal artery resistive index in CB was significantly higher (P < 0.025 than those in EA and the physiological state. Renal interlobar artery resistive and pulsatility indices in CB were significantly higher (P < 0.016 than those of moderate EA and the physiological state. The similar haemodynamic patterns in CB and EA are attributable to anaemia, while significant differencesmayadditionally be attributed to pathophysiological factors peculiar to CB.

  1. A Preliminary Investigation of Wastewater Treatment Efficiency and Economic Cost of Subsurface Flow Oyster-Shell-Bedded Constructed Wetland Systems

    Directory of Open Access Journals (Sweden)

    Chia-Chuan Hsu

    2013-06-01

    Full Text Available We conducted a preliminary investigation of wastewater treatment efficiency and economic cost of the oyster-shell-bedded constructed wetlands (CWs compared to the conventional gravel-bedded CW based on field monitoring data of water quality and numerical modeling. Four study subsurface (SSF CWs were built to receive wastewater from Taipei, Taiwan. Among these sites, two are vertical wetlands, filled with bagged- (VA and scattered- (VB oyster shells, and the other two horizontal wetlands were filled with scattered-oyster shells (HA and gravels (HB. The BOD, NO3−, DO and SS treatment efficiency of VA and VB were higher than HA and HB. However, VA was determined as the best option of CW design due to its highest cost-effectiveness in term of BOD removal (only 6.56 US$/kg as compared to VB, HA and HB (10.88–25.01 US$/kg. The results confirmed that oyster shells were an effective adsorption medium in CWs. Hydraulic design and arrangement of oyster shells could be important in determining their treatment efficiency and cost-effectiveness. A dynamic model was developed to simulate substance transmissions in different treatment processes in the CWS using AQUASIM 2.1 based on the water quality data. Feasible ranges of biomedical parameters involved were determined for characterizing the importance of different biochemical treatment processes in SSF CWs. Future work will involve extending the experimental period to confirm the treatment efficiency of the oyster-shell-bedded CW systems in long-term operation and provide more field data for the simulated model instead of the literature values.

  2. Preliminary on the isotope hydrology investigations at the Nevada test site: Hydrologic resources management program; FY 1992--1993

    Energy Technology Data Exchange (ETDEWEB)

    Davisson, M.L.; Kenneally, J.M.; Smith, D.K.; Hudson, G.B.; Nimz, G.J.; Rego, J.H.

    1994-01-01

    A comprehensive isotope data base of the NTS groundwaters collected during FY 92-93 is presented with preliminary interpretations. Multiple samples were collected from over 30 sites on pumped wells and open-holes by wireline bailing. Field water level measurements indicate essentially a bimodal distribution separated by water levels at higher elevations (e.g. Pahute Mesa) from water levels of lower elevations (e.g. Yucca and Frenchman Flats). Down hole temperature measurements have confirmed anomalous temperature gradients in the eastern Yucca Flat area and on Pahute Mesa, where horizontal temperature gradients up to 0.33{degrees}F/100ft are found. Consistent with previous reports by others, the major ion geochemistry of the NTS groundwater are dominated by Na-K-HCO{sub 3} and Ca-Mg-HCO{sub 3} water types, where the Na-rich water appears to be related to dissolution in the volcanic tuffs and the Ca-rich water to the Paleozoic carbonates. Increases in dissolved Si also seems to be indicative of groundwater that resides in the volcanic tuffs. Processes controlling the Na/Ca ratios are complex and may include ion exchange reactions with clays, evaporative concentration in the vadose zone, and lithological heterogeneities in addition to simple differential dissolution between the volcanic tuffs and the Paleozoic carbonates. Apparent {sup 14}C ages range between 4000 and 38,000 years for groundwaters at the NTS. The uncertainty is large for exact age determinations at this time. The {sup 14}C abundance decreases with increased dissolved HCO{sub 3}, and {sup 13}C suggests dissolution of the ``dead`` Paleozoic carbonates significantly influence the ages, but more work is needed to investigate the influence of vadose zone carbonate.

  3. Preliminary investigation by liquid chromatography tandem mass spectrometry of perfluorinated compounds presence in bass reared and fished in Italy

    Directory of Open Access Journals (Sweden)

    Federica Farabegoli

    2013-12-01

    Full Text Available The term perfluorinated compounds (PFCs defines synthetic fully-fluorinated compounds; since the 50s they have been largely employed in a wide range of industrial and consumer applications, due to their chemical and physical properties. Only recently, research on their potential adverse effects on both the environment and human health has been conducted, highlighting carcinogenic activity, toxic effects on reproduction, liver and kidney. Human exposure to PFCs is mainly through diet, and in particular fishery products are one of the most contaminated food. Perfluorooctane sulfonate (PFOS and perfluorooctanoic acid (PFOA are the two most important and investigated compounds of this group. The aim of this work was to carry out a preliminary monitoring on the presence of these two molecules in 50 bass muscle samples, of which 30 reared and 20 fished, collected from different Italian areas of the Mediterranean Sea. The method used was based on extraction with organic solvent followed by two purification steps: one with salts and one with dispersive solid phase. The extract was finally analysed by means of an ultra performance liquid chromatographytandem mass spectrometric system. Data showed a relevant contamination of this species and evidenced a significant difference of concentrations between fished (PFOS 112.4- >2000 ng/L and PFOA 3.3-487.0 ng/L and reared basses (PFOS 11.1-104.5 ng/L and PFOA <3-51.4 ng/L. Even if these levels of contamination are sensibly lower than those observed in several studies, fished basses could represent a more relevant source of PFCs exposure in human diet.

  4. Cetuximab in the treatment of head and neck cancer: preliminary results outside clinical trials

    Directory of Open Access Journals (Sweden)

    Didier Dequanter

    2010-06-01

    Full Text Available Didier Dequanter, Mohammad Shahla, Pascal Paulus, Phillippe LothaireDepartment of Head and Neck Surgery, CHU Charleroi, Montigny le Tilleul, BelgiumIntroduction: The purpose of this study was to evaluate the clinical efficacy in our daily practice, outside clinical trials, of cetuximab plus radiotherapy in a majority of treatment-naive patients with locoregionally advanced head and neck squamous cell carcinomas.Methods: A retrospective study was performed to evaluate outcomes in patients who were treated definitively with cetuximab and radiotherapy (ExRT. Patients with stage III or IV, nonmetastatic, measurable squamous cell carcinoma of the head and neck (SCCHN were eligible.Results: There were 18 males and two females. The median age was 61 years (range from 49 to 87 years old. Concurrent radiotherapy and cetuximab was used, in first line, in 17 patients with locally advanced disease; two patients with recurrent SCCHN, who were intolerant of Cisplatin-based regimens, were treated with radiotherapy combined with weekly cetuximab; and 1 patient received cetuximab and radiotherapy postoperatively. The median time of response was 10 months (range from 2 to 24 months. A partial response was observed in 11 cases; a complete response in nine cases. The occurrence of grade 2–3 skin toxicity was observed in 11 cases. Skin toxicity was clearly correlated with a better response and the duration of the response to the treatment. The use of cetuximab in combination with radiotherapy does not increase the side effects of radiotherapy. At the end of the follow-up, 17 patients died.Conclusion: Cetuximab, with its highly targeted mechanism of action and synergistic activity with current treatment modalities, is a valuable treatment option in head and neck patients. The effect of the epidermal growth factor receptor antagonist occurs without any change in the pattern and the severity of toxicity usually associated with head and neck radiation. Cetuximab seems

  5. Clinical investigation on application of water swallowing to MR esophagography

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Jinping, E-mail: zjpmri@163.com [Department of Radiology, Tongling People' s Hospital, Bijiashan Road 468, Tongling 244000, Anhui (China); Hu, Weijian; Zang, Lin [Department of Cardiothoracic Surgery, Tongling People' s Hospital, Bijiashan Road 468, Tongling 244000, Anhui (China); Yao, Yibin; Tang, Yongxiang; Qian, Zhen; Gao, Ping; Wu, Xiaoyan; Li, Shijian [Department of Radiology, Tongling People' s Hospital, Bijiashan Road 468, Tongling 244000, Anhui (China); Xie, Zhenlan; Yuan, Xiaoqing [Department of Pathology, Tongling People' s Hospital, Bijiashan Road 468, Tongling 244000, Anhui (China)

    2012-09-15

    Objective: To verify the clinical outcomes of applying water swallowing to MR esophagography. Methods: Thirty patients confirmed postoperatively or histopathologically with thoracic esophageal carcinoma by endoscopic biopsy and 10 healthy volunteers with normal esophagus underwent respectively conventional magnetic resonance imaging (MRI) detection and water swallowing MR esophagography. Of those patients, 4 underwent second examination after radiotherapy. Assessment on imaging effects of MR esophagography was performed. Assessment on definition on MR esophagography of the tumor in both upper and lower ends, specific localization, tumor size finally measured, coincidence with the gross pathologic types and tumor staging were respectively performed by comparison with conventional MRI. Additionally, we evaluated the outcomes of radiotherapy by comparing the previous MR esophagography with the second one with interventional technique. Results: Of the total 44 images of MR esophagography, 97.7% (43/44) were in high resolution by sagittal view and 81.8% (36/44) by cross-section. 93.3% (56/60) of the MR esophagography were clearly defined with the neoplastic lesion ends in the 30 patients with thoracic esophageal carcinoma, compared with 11.7% (7/60) by conventional MRI. The results were totally different in statistics (P < 0.005). Preoperative conventional MRI detection of the 22 cases in 25 undergone radical resection suggested vague diameter of the primary tumor and impossibly identified it at middle-lower thoracic esophagus in 5, and even failed to confirm gross pathologic types in 19 cases. Yet, MR esophagography with water swallowing represented accurate tumor length (graded as excellent) in 88% (22/25), localization in 100% (25/25), exact gross pathologic types in 88% (22/25), and accuracy for tumor staging in 80.8% (21/26) compared to 92.3% (24/26) by conventional MRI. Therapeutic effects achieved in 4 patients with radiotherapy. Conclusions: MR esophagography

  6. Annual Progress Report FY 93 (Walter Reed Army Medical Center, Department of Clinical Investigation). Clinical Investigation Program. Volume 2

    Science.gov (United States)

    1993-01-01

    13,141 Total: $ 13,141 STUDY OBJECTIVE To examine the potential role for gamma-aminobutyric acid (GABA) in the regulation of respiration . TECHNICAL...Association of Acromegaly and Intermediate Markers of Neoplasia KEYWORDS: acromegaly , colonic neoplasia PRINCIPAL INVESTIGATOR: Murphy, Joseph MAJ MC...acromegalics, to identify risk factors, and to determine if there is a correlation between disease activity in acromegaly and intermediate markers of

  7. Clinical investigation of upper gastrointestinal hemorrhage after percutaneous endoscopic gastrostomy.

    Science.gov (United States)

    Nishiwaki, Shinji; Araki, Hiroshi; Takada, Jun; Watanabe, Naoki; Asano, Takahiko; Iwashita, Masahide; Tagami, Atsushi; Hatakeyama, Hiroo; Hayashi, Takao; Maeda, Teruo; Saito, Koshiro

    2010-07-01

    Upper gastrointestinal (GI) hemorrhage after percutaneous endoscopic gastrostomy (PEG) is sometimes reported as one of the serious complications. Our purpose was to clarify the cause of upper GI hemorrhage after PEG. We retrospectively investigated the causes of upper GI hemorrhage among a total of 416 patients out of 426 consecutive patients who underwent PEG in our institution, excluding 10 patients who showed upper GI tumors on PEG placement. Among 17 patients who developed upper GI hemorrhage after PEG, three and four patients showed PEG tube placement and replacement-related hemorrhage, respectively; these lesions were vascular or mucosal tears around the gastrostomy site. Ten patients experienced 12 episodes of upper GI hemorrhage during PEG tube feeding. The lesions showing bleeding were caused by reflux esophagitis (five patients), gastric ulcer (two patients), gastric erosion due to mucosal inclusion in the side hole of the internal bolster (two patients), and duodenal diverticular hemorrhage (one patient). Anticoagulants were administered in six patients, including four patients with replacement-related hemorrhage and one patient each with reflux esophagitis and gastric ulcer. Reflux esophagitis was the most frequent reason for upper GI hemorrhage after PEG. The interruption of anticoagulants should be considered for the prevention of hemorrhage on the placement as well as replacement of a gastrostomy tube.

  8. Good clinical practice regulatory inspections: Lessons for Indian investigator sites

    Directory of Open Access Journals (Sweden)

    R Marwah

    2010-01-01

    Full Text Available Regulatory inspections are important to evaluate the integrity of the data submitted to health authorities (HAs, protect patient safety, and assess adequacy of site/sponsor quality systems to achieve the same. Inspections generally occur after submission of data for marketing approval of an investigational drug. In recent years, there has been a significant increase in number of inspections by different HAs, including in India. The assessors/inspectors generally do a thorough review of site data before inspections. All aspects of ICH-GCP, site infrastructure, and quality control systems are assessed during the inspection. Findings are discussed during the close out meeting and a detailed inspection report issued afterward, which has to be responded to within 15-30 days with effective Corrective and Preventive Action Plan (CAPA. Protocol noncompliance, inadequate/inaccurate records, inadequate drug accountability, informed consent issues, and adverse event reporting were some of the most common findings observed during recent Food and Drug Administration (FDA inspections. Drug development is being increasingly globalized and an increased number of patients enrolled in studies submitted as part of applications come from all over the world including India. Because of the steep increase in research activity in the country, inexperienced sites, and more stakeholders, increased efforts will be required to ensure continuous quality and compliance. HAs have also made clear that enforcement will be increased and be swift, aggressive, and effective.

  9. Glass fiber reinforcement in repaired acrylic resin removable dentures: preliminary results of a clinical study.

    Science.gov (United States)

    Vallittu, P K

    1997-01-01

    The clinical usefulness of continuous E-glass partial fiber reinforcement of acrylic resin removable dentures was evaluated an average 13 months after the insertion of the fibers. Twelve removable complete dentures and ten removable partial dentures with a history of recurrent fracture were selected for this study. The partial fiber reinforcement was incorporated into the denture at the time of repair. One complete denture and one removable partial denture fractured in the region of reinforcement during the examination period. These fractures were most likely caused by faulty placement of the fiber reinforcement in the denture in the dental laboratory. In six dentures, new fractures occurred in regions without partial fiber reinforcement. The results revealed the importance of both the correct positioning of the partial fiber reinforcement in the denture and the use of accurate laboratory techniques.

  10. Focal choroidal excavation: a preliminary interpretation based on clinic and review

    Institute of Scientific and Technical Information of China (English)

    Guang-Hui; Liu; Bing; Lin; Xin-Quan; Sun; Zi-Fang; He; Ji-Rong; Li; Rong; Zhou; Xiao-Ling; Liu

    2015-01-01

    AIM: To describe the clinical and imaging characteristics associated with focal choroidal excavation(FCE), analyze the possible complication, and interpret its probable etiopathogenesis.METHODS: Retrospective descriptive case series of 37 eyes of 32 patients with FCE. Findings of spectral-domain optical coherence tomography(SD-OCT),fluorescein angiography, indocyanine green angiography,and clinical features were analyzed. RESULTS: All patients were Chinese. Five patients(15.6%) were bilaterally involved. Patients’ ages ranged from 7 to 66 y. Refractive error ranged between +2.0 D and 11.0 D. Mean best-corrected visual acuity was 0.6(range, 0.1 to 1.2). Fundus examinations exhibited mild-moderate localized pigmentary disturbances in the corresponding area of 17 eyes. Fluorescein angiography performed in 18 patients showed varying degrees of hyperfluorescence and hypofluorescence related to a range of retinal pigment epithelium(RPE) alterations.Indocyanine green angiography performed in 7 patients showed hypofluorescence at the excavation. SD-OCT demonstrated choroidal excavation in all 37 eyes.Twenty-nine eyes showed a single lesion of FCE, and three eyes showed 2-3 separated lesions. Fifteen eyes showed separation between the photoreceptor tips andRPE consistent with nonconforming FCE. Central serous chorioretinopathy(CSC, n =1) and choroidal neovascularization(CNV, n =1) developed during follow-up.CONCLUSION: FCE could be interpreted as congenital focal choroidal dysplasia involving the RPE,choriocapillaris, and photoreceptor associated with the faulty anatomy. The abnormal anatomy of FCE was similar to anatomy at risk of CSC and CNV.

  11. 当阳峪窑址群考察纪略%THE INVESTIGATION AND PRELIMINARY STUDY OF DANG YANG YU KILNSITE

    Institute of Scientific and Technical Information of China (English)

    王建保

    2011-01-01

    Through the investigation and preliminary study of 19 kilnsites at Dang Yang Yu kiln , I basically master the modeling, decoration and fire craft of porcelain works with white glaze, dichroic glaze,twistable glaze, twistable color, dark brown glaze, black glaze, green glaze, Jun glaze and three-color glazed pottery, emerald glazed pottery of Dang Yang Yu kiln, and find the material about “double-firing process” .Through the investigation, I find Dang Yang Yu kiln' s first burning was in the late Tang Dynasty. During its first burning and development phases, Dang Yang Yu kiln was influenced by Gongyi kiln, Yaozhou kiln,Xing kiln, Ding kiln, Cizhou kiln, Jun kiln and other kilns nearby at different degree. The generalized Dang Yang Yu kiln is Huaiqing kiln according to the literature, and the ancient kiln at Boai county local is Henei kiln. Dang Yang Yu kiln reached its height of prosperity at Song and Jin period, it influenced and promoted the development of Zibo kiln and other kilns nearby, and went down to Qing Dynasty. Besides satisfying common market consumption, Dang Yang Yu kiln also went into the rank of tribute because of its outstanding quality.%通过对当阳峪窑19处窑址的考察与初步研究,基本掌握了当阳峪窑白釉、双色釉、绞胎、绞彩、酱釉、黑釉、青釉、钧釉瓷器和三彩、翠兰釉陶器的造型、装饰和烧造工艺,发现"二次烧成"的资料.通过研究,发现当阳峪窑始烧于唐代晚期.在其创烧与发展阶段,受到了巩义窑、耀州窑、邢窑、定窑、磁州窑及钧窑等周边窑口不同程度的影响.广义的当阳峪窑即文献记载的怀庆窑,博爱县地域的古代窑场即文献记载的河内窑.当阳峪窑在宋金时期达到鼎盛,影响、促进了淄博窑等周边窑口的发展,并延续至清代.除了满足一般性的市场消费,由于品质优秀,还跻身贡奉之列.

  12. General issues and precautions in the design for clinical trials of investigational new drugs.

    Science.gov (United States)

    Hu, Liang-ping; Bao, Xiao-lei

    2011-02-01

    The general problems existing in the clinical trials of investigational new drugs involve some key aspects such as the guiding principles, research designs, quality controls and statistical analyses. This paper explores the eight general issues in the clinical trials of investigational new drugs and presents precautionary measures with high operability. Research on the clinical trials of investigational new drugs is a complex project, which should be carried out strictly according to the policies, laws, criteria and operating rules set by related agencies. The neglect of research designs and data analyses will lead clinical trials to failure.

  13. 76 FR 80948 - Draft Guidance for Industry, Clinical Investigators, Institutional Review Boards, and Food and...

    Science.gov (United States)

    2011-12-27

    ... developed to promote the initiation of clinical investigations to evaluate the medical devices under FDA's... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry, Clinical Investigators, Institutional Review Boards, and Food and Drug Administration Staff; Food and Drug Administration Decisions...

  14. Hyperthermic intraperitoneal chemotherapy with mitomycin C and 5-fluorouracil in patients at high risk of peritoneal metastasis from colorectal cancer: A preliminary clinical study.

    Science.gov (United States)

    Shimizu, Tomoharu; Murata, Satoshi; Sonoda, Hiromichi; Mekata, Eiji; Ohta, Hiroyuki; Takebayashi, Katsushi; Miyake, Tohru; Tani, Tohru

    2014-05-01

    Although hyperthermic intraperitoneal chemotherapy (HIPEC) has been extensively used to treat patients with peritoneal metastases (PM) from colorectal cancer (CRC), a standard protocol has not yet been established. The aim of this preliminary clinical study was to confirm in vitro the efficacy of mitomycin C combined with 5-fluorouracil (MMC-5FU) under hyperthermic conditions in CRC and investigate the pharmacokinetics and feasibility of HIPEC with MMC-5FU for patients at high risk of PM from CRC. To simulate HIPEC in vitro, we used the collagen gel droplet-embedded culture drug sensitivity test with the HCT166 colorectal cell line to assess the antitumor efficacy of MMC and 5FU as single-agent and combination treatments following incubation with HCT116 cells for 30 min at either 37 or 42°C. In addition, five patients at high risk of PM from CRC underwent surgical tumor resection followed by HIPEC with MMC-5FU. Our results demonstrated that the combined administration of MMC-5FU suppressed tumor cell proliferation more efficiently compared to either agent used alone. In addition, hyperthermia at 42°C significantly enhanced drug sensitivity. During the clinical application of HIPEC with MMC-5FU, no grade 4 hematological toxicities or surgical adverse events were recorded. In addition, there was no evidence of peritoneal recurrence during a median observational period of 38 months. Of note, two patients with positive intraoperative peritoneal cytology at the first surgery developed no peritoneal recurrence and exhibited negative peritoneal cytology at the second surgery. In conclusion, HIPEC using MMC-5FU was shown to be a feasible therapeutic option, with an acceptable toxicity profile, for patients at high risk of PM from CRC. Therefore, HIPEC with MMC-5FU may be a promising novel therapeutic option for such patients, which merits further verification of its safety and efficacy in large-scale clinical trials.

  15. Preclinical and Clinical Investigation of the Impact of Obesity on Ovarian Cancer Pathogenesis

    Science.gov (United States)

    2014-10-01

    Award Number: W81XWH-12-1-0426 TITLE: Preclinical and Clinical Investigation of the Impact of Obesity on Ovarian Cancer Pathogenesis PRINCIPAL...ANNUAL 25 Sep 2013 - 24 Sep 2014 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Pre-clinical and Clinical Investigation of the Impact of Obesity on Ovarian...metabolic consequences of obesity may be critical in the development of ovarian cancer (OC), resulting in biologically different cancers than those that

  16. Preliminary clinical and radiographic results of large ceramic heads on highly cross-linked polyethylene.

    Science.gov (United States)

    Meftah, Morteza; Ebrahimpour, Prouskeh Bruce; He, Chuan; Ranawat, Amar S; Ranawat, Chitranjan S

    2011-06-14

    Data are limited regarding large ceramic femoral heads with highly cross-linked polyethylene. We hypothesized that large ceramic head articulation with highly cross-linked polyethylene is safe with a low wear rate, comparable to metal-on-highly cross-linked polyethylene.The study group comprised 63 patients (72 hips) who had undergone total hip replacement (THR) with ceramic-on-highly cross-linked polyethylene between April 2006 and March 2007 with a minimum 2-year follow-up. Postoperative Western Ontario and Mc-Master Universities Arthritis Index (WOMAC) and Hospital for Special Surgery (HSS) scores were used for clinical assessment. Six-week and 2-year radiographs were analyzed by 2 independent observers using Roman 1.70 software. Twenty-six patients (29 hips) had 32-mm and 37 patients (43 hips) had 36-mm Biolox delta ceramic femoral heads (Ceramtec, Plochingen, Germany). Mean patient age was 60.9 ± 8.9 years, and mean follow-up was 2.9 ± 0.5 years. Mean postoperative WOMAC and HSS hip scores were 30.4 and 36.6, respectively. Mean wear at 1 and 2 years postoperatively was 0.06 ± 0.28 and 0.006 ± 0.12 mm/yr for all hips, respectively. Mean wear at 1 and 2 years postoperatively for the 32-mm femoral head was 0.063 ± 0.278 and 0.007 ± 0.126 mm/yr, respectively, and for the 36-mm femoral head was 0.057 ± 0.292 and 0.006 ± 0.118 mm/yr, respectively. No patient had any clinical complications, such as reoperation, infection, fractures, or radiographic evidence of osteolysis or loosening. The early results of THR with large ceramic heads demonstrate high safety and efficacy. Our data with 2-year follow-up show low wear rates, similar to published data for metal-on-highly cross-linked polyethylene.

  17. Cortisol and cortisone ratio in urine: LC-MS/MS method validation and preliminary clinical application.

    Science.gov (United States)

    Antonelli, Giorgia; Artusi, Carlo; Marinova, Mariela; Brugnolo, Laura; Zaninotto, Martina; Scaroni, Carla; Gatti, Rosalba; Mantero, Franco; Plebani, Mario

    2014-02-01

    The determination of urinary cortisol/cortisone ratio is of clinical utility in cases of Cushing's syndrome, apparent mineralocorticoid excess, and also provides information on 11β-hydroxysteroid dehydrogenase (11β-HSD) type 2 activity. It is therefore of utmost importance to ensure accurate cortisol and cortisone measurement and establish appropriate reference ranges. After the isotopic dilution of urine, sample cleanups were obtained with on-line solid-phase extraction and cortisol and cortisone, separated using a Zorbax Eclipse XDB-C18 HPLC analytical column, were analyzed by tandem mass spectrometry with an electrospray ionization source in positive ion mode operation. The method was linear, with concentrations of up to 625 and 1125 nmol/L and lower limit of quantitation (LLOQ) of 5 and 6 nmol/L, for cortisol and cortisone, respectively. Within-run and between-run coefficients of variation were cortisone, respectively. No ion suppression was observed. The non-parametric reference range for the cortisol/cortisone ratio was 0.14-1.09. A simple and sensitive liquid chromatography tandem mass spectrometry method was developed and validated for the measurement of cortisol and cortisone in urine. Our findings indicate that the proposed analytical method is suitable for routine purposes and useful in many pathological conditions.

  18. The opinion of post graduate students on objective structured clinical examination in Anaesthesiology: A preliminary report

    Directory of Open Access Journals (Sweden)

    Parul Jindal

    2016-01-01

    Full Text Available Background and Aims: The scenario in medical education is changing with objective structured clinical examination (OSCE being introduced as an assessment tool. Its successful implementation in anaesthesiology postgraduate evaluation process is still limited. We decided to to evaluate the effectiveness of OSCE and compare it to conventional examinations as formative assessment tools in anaesthesiology. Methods: We conducted a cross-sectional comparative study in defined population of anaesthesiology postgraduate students to evaluate the effectiveness of OSCE as compared to conventional examination as formative assessment tool in anaesthesiology. Thirty-five students appeared for the conventional examination on the 1st day and viva voce on the 2nd day and OSCE on the last day. At the conclusion of the assessment, all the students were asked to respond to the perception evaluation questionnaire. We analysed the perception of OSCE among the students. Results: Results showed a positive perception of the objective structured physical examination (OSCE as well as structured 9 (25.7%, fair 19 (54.2% and unbiased 13 (37.1% with more standardised scoring 9 (25.7%. The students perceived OSCE to be less stressful than other examination. Thirty-one (88.5% students agreed that OSCE is easier to pass than conventional method and 29 (82.5% commented that the degree of emotional stress is less in OSCE than traditional methods. Conclusion: OSCE is better evaluation tool when compared to conventional examination.

  19. Clinical implications and applications of the twinkling sign in ureteral calculus: a preliminary study.

    Science.gov (United States)

    Sharma, Gyanendra; Sharma, Anshu

    2013-06-01

    Twinkling is an artifact seen on color Doppler ultrasound as a rapidly changing mixture of red and blue behind a stationary echogenic structure. We studied the presence or absence of this artifact in ureteral calculi detected on ultrasound and correlated it with clinical parameters. We evaluated 284 ureteral calculi seen on color Doppler ultrasound. The twinkling artifact was graded as 0 to 2 and correlated with the presence or absence of pain, symptom duration, degree of hydronephrosis and passage of a Glidewire® guidewire across the ureteral calculus during ureterorenoscopy. The presence or absence of twinkling was not associated with the degree of hydronephrosis. Twinkling was absent in 92% of patients with significant pain and grade 2 twinkling was seen in 69.5% without significant pain. Twinkling was dominantly absent in patients with a recent colic episode, while 77% who presented 2 to 15 days after a colic episode had grade 2 twinkling. The guidewire was difficult to pass in cases with absent twinkling compared to those with grade 2 twinkling, in which the guidewire and ureteral catheter crossed the calculus easily. Absent twinkling is associated with significant pain, a recent colic episode and difficult guidewire passage across the calculus. These findings suggest that absent twinkling implies significant obstruction, while its presence indicates no significant obstruction. Copyright © 2013 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  20. Reconstruction of intraoral defects with superior labial artery musculo-mucosal flap: a preliminary clinical study.

    Science.gov (United States)

    Güven, Erdem; Uğurlu, Alper Mete; Başaran, Karaca; Basat, Salih Onur; Yiğit, Bariş; Hafiz, Günter; Kuvat, Samet Vasfi

    2010-01-01

    In this article, we present the use of the superior labial artery musculo-mucosal (SLAMM) flap for intraoral reconstruction. The study included five patients (2 females, 3 males; mean age 36 years; range 11 to 56 years) who consulted at our clinic between October 2008 and January 2010. Five oral defects were reconstructed with the SLAMM flap. Three patients underwent reconstruction with SLAMM flap following oncologic resection. The other two patients had traumatic defects in the oral cavity which necessitated flap application. First, the distal end of the flap was incised and the superior labial artery was identified after dissection. After ligation of the artery, the mucosa, submucosa and the cuff of orbicularis oris muscle were elevated. The dissection was extended laterally and anteriorly, depending on the necessary flap size. None of the patients had partial or total flap necrosis. During the follow-up period, contracture developed in only one patient. Successful reconstruction was observed in all patients. The superior labial artery musculo-mucosal flap is a simple and feasible technique which can be used for reconstruction of intraoral defects.

  1. Bronchial stump fistula :treatment with covered retrievable hinged metallic stents-preliminary clinical experience

    Institute of Scientific and Technical Information of China (English)

    LI Yong-dong; HAN Xin-wei; WU Gang; LI Ming-hua

    2007-01-01

    Objective To evaluate the preliminaily clinical efficacy and retrievability of a retrievable hinged covered metallic stent in the treatment of the bronchial stump fistula (BSF). Methods Between April 2003 and March 2005, 8 patients with bronchial stump fistula after pneumonectomy or lobectomy were treated with two types (A and B) of retrievable hinged covered metallic stents. Type A stent was placed in 6 patients and type B in 2 under fluoroscopic guidance. The stent was removed with a retrieval set when BSF was healed or complications occurred. Results Stent placement in the bronchial tree was technically successful in all patients, without procedure-related complications. Immediate closure of the BSF was achieved in all patients after the procedure. Stents were removed from all patients but one. Removal of the stents was difficult in two patients due to tissue hyperplasia. Patients were followed up for 6 - 21 months. Placement of the stents remained stable in all patients except one due to severe cough. Permanent closure of BSF was achieved in 7(87.5%) of 8 patients. Conclusion Use of a retrievable hinged covered expandable metallic stent is a simple,safe, and effective procedure for closure of the BSF. Retrieval of the stent seems to be feasible. (J Intervent Radiol, 2007, 16: 253-257)[ Key words ] Fistula, pulmonary; Bronchialpleural fistula; Stents and prostheses; Computed tomography

  2. [The design of plantar pressure distribution monitoring system and preliminary clinical application].

    Science.gov (United States)

    Zhu, Xianfeng; Zhao, Zilei; Xu, Donghao; Xu, Dongming

    2014-04-01

    Plantar pressure distribution can reflect the force of several key points on foot while standing and walking. A comprehensive understanding of the plantar pressure distribution makes great sense in the following aspects: the understanding of the normal foot biomechanics and function, clinical diagnosis, measurement of disease extent, postoperative efficacy evaluation, and rehabilitation research. A simple plantar pressure measurement device was designed in this study. This paper uses FlexiForce flexible sensor to pickup plantar pressure signal and USB A/D board to do data acquisition. The data are transferred into a laptop and processed by a VB-based software which can display, remember and replay the data. We chose patients with hallux valgus and normal people to measure the pressure distribution and make contrast analysis of plantar pressure with this device. It can be concluded that people with hallux valgus have higher pressure on the second metatarsophalangeal joint and the distribution move outward. The plantar pressure of patients postoperative could be greatly improved compared to the preoperative. The function of this device has been confirmed.

  3. [Preliminary study on clinical application of robotic sacral hysteropexy in treatment of uterine prolapse].

    Science.gov (United States)

    Li, Xiuli; Zhou, Ning; Yang, Yizhuo; Liu, Zhongyu; Yao, Yuanqing

    2014-06-01

    To study the clinical efficacy of robotic sacral hysteropexy in treatment of uterine prolapse. From January 2012 to December 2013, 3 patients undergoing robotic sacral hysteropexy in treatment of uterine prolapse in General Hospital of People's Liberation Army were studied retrospectively. Operation time, blood loss and postoperative recovery exhaust time and pelvic organ prolapse quantification (POP-Q) staging were evaluated. Three patients were treated by robotic sacral hysteropexy successfully. The mean operation time was 221 minutes (210-240 minutes), mean blood loss was 45 ml. One case with II degree perineal laceration patients simultaneously perineal repair, neither intra-nor post-operative complications occurred. The mean postoperative recovery exhaust time was 16 hours. At three months of follow-up, all 3 patients got satisfaction. Although one patient at the first six months of postoperation had leakage of urine when coughing, instruct exercise pelvic floor muscle function and acupuncture one month their symptoms disappear. Robotic sacral hysteropexy pave the way for an effective option in the management of uterine prolapse.

  4. A Structured Clinical Interview for Kleptomania (SCI-K): preliminary validity and reliability testing.

    Science.gov (United States)

    Grant, Jon E; Kim, Suck Won; McCabe, James S

    2006-06-01

    Kleptomania presents difficulties in diagnosis for clinicians. This study aimed to develop and test a DSM-IV-based diagnostic instrument for kleptomania. To assess for current kleptomania the Structured Clinical Interview for Kleptomania (SCI-K) was administered to 112 consecutive subjects requesting psychiatric outpatient treatment for a variety of disorders. Reliability and validity were determined. Classification accuracy was examined using the longitudinal course of illness. The SCI-K demonstrated excellent test-retest (Phi coefficient = 0.956 (95% CI = 0.937, 0.970)) and inter-rater reliability (phi coefficient = 0.718 (95% CI = 0.506, 0.848)) in the diagnosis of kleptomania. Concurrent validity was observed with a self-report measure using DSM-IV kleptomania criteria (phi coefficient = 0.769 (95% CI = 0.653, 0.850)). Discriminant validity was observed with a measure of depression (point biserial coefficient = -0.020 (95% CI = -0.205, 0.166)). The SCI-K demonstrated both high sensitivity and specificity based on longitudinal assessment. The SCI-K demonstrated excellent reliability and validity in diagnosing kleptomania in subjects presenting with various psychiatric problems. These findings require replication in larger groups, including non-psychiatric populations, to examine their generalizability. Copyright (c) 2006 John Wiley & Sons, Ltd.

  5. Clinical utility of the Multiple Errands Test in schizophrenia: A preliminary assessment.

    Science.gov (United States)

    Bulzacka, Ewa; Delourme, Gwenaëlle; Hutin, Valérie; Burban, Nathalie; Méary, Alexandre; Lajnef, Mohamed; Leboyer, Marion; Schürhoff, Franck

    2016-06-30

    Schizophrenia (SZ) is a chronic, severe disease, which results in misperception of reality, major social withdrawal, and cognitive disturbances. One type of cognitive disturbance, known as executive dysfunction, is widely considered as a primary determinant of functional outcome. However, classic neuropsychological measures of executive functioning (EF) poorly represent patients' functional outcome, and thus seem inappropriate for evaluating the real-world functional impact of diseases such as SZ. We hypothesized that the Multiple Errands Test (MET), an ecological assessment of executive function would show greater ability to measure everyday adaptive functioning SZ, compared to conventional EF assessment methods. 100 clinically stable SZ patients were administered the MET, Wisconsin Card Sorting Test - 64 and a paper version of MET. Correlation analyses were performed between each EF measure and functional outcome, as measured by the Social Autonomy Scale (SAS). After adjusting for age, education, IQ and illness duration, SAS was significantly predicted by MET global score. No other EF measure correlated with SAS. Results from this study suggest that MET offers a valuable prediction of daily life functional outcome in this large sample of SZ patients. Therefore, it could be used as a complementary measure to improve the identification of executive dysfunctions prior to psychosocial interventions.

  6. Preliminary Clinical Studies Using A Self Scanning Lineak Diode Array To Obtain 1024 X 1024 Digital Radiographs

    Science.gov (United States)

    Sashin, Donald; Slasky, B. Simon; Sternglass, Ernest J.; Bron, Klaus M.; Herron, John M.; Kennedy, William H.; Boyer, Joseph W.; Girdany, Bertram R.; Simpson, Raymond W.; Horton, Joseph A.

    1984-08-01

    A digital radiography system using self scanning linear diode arrays is being developed for improved diagnosis at reduced radiation dose. Our technique is based on the use of solid state sensors with 1024 diodes per inch and with very high dynamic range. The slit geometry of our method results in image improvement and dose reduction by efficiently rejecting scattered x-rays in the patient. In our present configuration the images have a field of view of six inches by six inches or 6 inches by 12 inches and are digitized to 1024 x 1024 pixels with 12 bits. This digital system differs from the conventional digital radiography in that no image intensifier TV fluoroscopy chain is required. Preliminary clinical studies have demonstrated the high detail of our system at low radiation levels. In dog studies the system has clearly visualized very small coronary arteries following aortic root injection of contrast material. Even with intravenous injections some of the coronary arteries could be seen.

  7. Bridging Autism Spectrum Disorders and Schizophrenia through inflammation and biomarkers - pre-clinical and clinical investigations.

    Science.gov (United States)

    Prata, Joana; Santos, Susana G; Almeida, Maria Inês; Coelho, Rui; Barbosa, Mário A

    2017-09-04

    In recent years, evidence supporting a link between inflammation and neuropsychiatric disorders has been mounting. Autism spectrum disorders (ASD) and schizophrenia share some clinical similarities which we hypothesize might reflect the same biological basis, namely, in terms of inflammation. However, the diagnosis of ASD and schizophrenia relies solely on clinical symptoms, and to date, there is no clinically useful biomarker to diagnose or monitor the course of such illnesses.The focus of this review is the central role that inflammation plays in ASD and schizophrenia. It spans from pre-clinical animal models to clinical research and excludes in vitro studies. Four major areas are covered: (1) microglia, the inflammatory brain resident myeloid cells, (2) biomarkers, including circulating cytokines, oxidative stress markers, and microRNA players, known to influence cellular processes at brain and immune levels, (3) effect of anti-psychotics on biomarkers and other predictors of response, and (4) impact of gender on response to immune activation, biomarkers, and response to anti-psychotic treatments.

  8. Physician to investigator: clinical practice to clinical research--ethical, operational, and financial considerations.

    Science.gov (United States)

    Pierre, Christine

    2008-01-01

    Physicians who participate in clinical research studies gain benefits for themselves, their practice, and their patients. Historically, private practice physicians have chosen to defer to their counterparts in academic medicine when it comes to contributing to scientific advancement through clinical studies. A growing number of private practice physicians are now taking a serious second look and deciding that there are unique benefits for both the practice and the patient. Physicians who decide to participate in clinical research should give serious consideration to the time and resources that are required to meet both federal regulations and industry standards. In addition, ethical and scientific principles for assuring the protection of human research subjects must be a paramount commitment.

  9. Adaptive clutter rejection for 3D color Doppler imaging: preliminary clinical study.

    Science.gov (United States)

    Yoo, Yang Mo; Sikdar, Siddhartha; Karadayi, Kerem; Kolokythas, Orpheus; Kim, Yongmin

    2008-08-01

    In three-dimensional (3D) ultrasound color Doppler imaging (CDI), effective rejection of flash artifacts caused by tissue motion (clutter) is important for improving sensitivity in visualizing blood flow in vessels. Since clutter characteristics can vary significantly during volume acquisition, a clutter rejection technique that can adapt to the underlying clutter conditions is desirable for 3D CDI. We have previously developed an adaptive clutter rejection (ACR) method, in which an optimum filter is dynamically selected from a set of predesigned clutter filters based on the measured clutter characteristics. In this article, we evaluated the ACR method with 3D in vivo data acquired from 37 kidney transplant patients clinically indicated for a duplex ultrasound examination. We compared ACR against a conventional clutter rejection method, down-mixing (DM), using a commonly-used flow signal-to-clutter ratio (SCR) and a new metric called fractional residual clutter area (FRCA). The ACR method was more effective in removing the flash artifacts while providing higher sensitivity in detecting blood flow in the arcuate arteries and veins in the parenchyma of transplanted kidneys. ACR provided 3.4 dB improvement in SCR over the DM method (11.4 +/- 1.6 dB versus 8.0 +/- 2.0 dB, p < 0.001) and had lower average FRCA values compared with the DM method (0.006 +/- 0.003 versus 0.036 +/- 0.022, p < 0.001) for all study subjects. These results indicate that the new ACR method is useful for removing nonstationary tissue motion while improving the image quality for visualizing 3D vascular structure in 3D CDI.

  10. Preliminary Data from an Advanced Dementia Consult Service: Integrating Research, Education, and Clinical Expertise

    Science.gov (United States)

    Catic, Angela G.; Mitchell, Susan L.

    2013-01-01

    Hospitalized patients with advanced dementia often receive care that is of limited clinical benefit and inconsistent with preferences. We designed an Advanced Dementia Consult Service and conducted a pre and post pilot study to evaluate it in a Boston hospital. Consults were conducted by geriatricians and palliative care nurse practitioner. They consisted of structured consultation, counseling and provision of an information booklet to the family, and post-discharge follow-up with the family and primary care providers. Patients > 65 admitted with advanced dementia were identified and consults were solicited using pop-ups programmed into the computerized provider order entry (POE) system. In the initial 3-month period, patients received usual care (N=24). In the subsequent 3-month period, consults were provided to patients for whom it was requested (N=5). Data were obtained from the electronic medical record and proxies interviews (admission, 1-month post-discharge). The patients’ mean age in the combined sample (N=29) was 85.4, 58.6% were from nursing homes, and 86.2% of their proxies stated comfort was the goal of care. Nonetheless, their hospitalizations were characterized by high rates of intravenous antibiotics (86.2%), > 5 venipunctures (44.8%), and radiological exams (96.6%). Acknowledging the small sample size, there were trends towards better outcomes in the intervention group including: higher proxy knowledge of the disease, greater communication between proxies and providers, more advance care planning, lower re-hospitalization rates, and fewer feeding tube insertions after discharge. Targeted consultation for advanced dementia is feasible and may promote greater engagement of proxies and goal-directed care for patients after discharge. PMID:24219202

  11. Preliminary Clinical Observation of Arteriovenous Sheathotomy for Treatment of Branch Retinal Vein Occlusion

    Institute of Scientific and Technical Information of China (English)

    Lin Lu; Yonghao Li; Changxian Yi; Mei Li; Xiulan Lu; Jinglin Zhang

    2003-01-01

    Purpose: To document the anatomic and functional improvement of six patients withbranch retinal vein occlusion (BRVO) following successful arteriovenous adventitialsheathotomy (AAS).Methods: Retrospective study of 6 patients (6 eyes) with BRVO treated with AAS. Allpatients were not eligible for laser photocoagulation and had both macular edema andintraretinal hemorrhage. The visual acuity was in the range of 0.4 to 0.02. All patientsunderwent pars plana vitrectomy and AAS. The clinical improvement was determined byfundus photograph, fluorescein angiography (FAG), optical coherence tomography(OCT) and multifocal electroretinography (ERG). All patients were followedpostoperatively for an average of 20 months ranging from 12 to 24 months.Results: Sheathotomy and decompression of the arteriole/venule (A/V) crossing wereachieved in all 6 patients. 5 patients have improved their best-corrected visual acuity 4lines or more. The best one could reach to 1.0. One month after the operation, fundusphotograph and FAG demonstrated the resolution of intraretinal hemorrhage, reduction ofnon-perfusion area and apparent resolution of retinal venous dilation and tortuosity. OCTconfirmed remarkable reduction of retinal thickness. The microcysts at the foveadiminished. Multifocal ERG showed the recovery of the central peak at the macular andthe peripheral response density. However, capillary nonperfusion area andmicroaneurysm were found out by FAG in four patients at the points distal to thesheathotomy three months after the operation.Conclusions: Anatomic and functional improvement of retina can be achieved in patientswith BRV0 through AAS. However, the capillary nonperfusion and microaneurysm mayfollow this surgical procedure in some cases that need further treatment with laserphotocoagulation. The better visual improvement may be expected in the patients withearlier surgical intervention.

  12. Fractionated stereotactic radiation therapy for intracranial benign tumor : preliminary results of clinical application

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Dae Yong; Ahn, Yong Chan; Huh, Seung Jae [Samsung Medical Center, Syungkyunkwan Univ. College of Medicine, Seoul (Korea, Republic of)] (and others)

    1998-06-01

    With the development of stereotactic immobilization systems capable of reliable serial repositioning, fractionated stereotactic radiation therapy(FSRT) offers the potential for an improved treatment outcome by excellent dose delivery, and dose distribution characteristics with the favorable radio-biological properties of fractionated irradiation. We describe our initial experience using FSRT for the treatment of intracranial benign tumor. Between August 1995 and December 1996, 15 patients(7 males and 8 females aged 6-70 years) were treated with FSRT. The patients had the following diagnosis : pituitary adenoma(10) including one patient who previously had received radiotherapy, craniopharyngioma(2), acoustic neurinoma(1), meningioma(2). Using the Gill-Thomas-Cos-man relocatable head frame and multiple non-coplanar therapy, the daily dose of 2Gy was irradiated at 90% to 100% isodose surface of the isocenter. The collimator sizes ranged from 26mm to 70mm. In all patients except one follow-up lost, disease was well-controlled. Acute complication was negligible and no patient experienced cranial nerve neuropathies and radiation necrosis. In overall patient setup with scalp measurements, reproducibility was found to have mean of 1.1{+-}0.6mm from the baseline reading. Relocatable stereotactic system for FSRT is highly reproducible and comfortable. Although the follow-up period was relatively short, FSRT is considered to be a safe an effective radiation technique as the treatment of intracranial tumor. But the fractionation schedule(fraction size, overall treatment time and total dose) still remains to be solved by further clinical trials.

  13. Preliminary investigation of plasma levels of sex hormones and human growth factor(s, and P300 latency as correlates to cognitive decline as a function of gender

    Directory of Open Access Journals (Sweden)

    Kerner Mallory M

    2009-07-01

    Full Text Available Abstract Background Aging is marked by declines in levels of many sex hormones and growth factors, as well as in cognitive function. The P300 event-related potential has been established as a predictor of cognitive decline. We decided to determine if this measure, as well as 2 standard tests of memory and attention, may be correlated with serum levels of sex hormones and growth factors, and if there are any generalizations that could be made based on these parameters and the aging process. Findings In this large clinically based preliminary study several sex-stratified associations between hormone levels and cognition were observed, including (1 for males aged 30 to 49, both IGF-1 and IGFBP-3 significantly associated negatively with prolonged P300 latency; (2 for males aged 30 to 49, the spearman correlation between prolonged P300 latency and low free testosterone was significant; (3 for males aged 60 to 69, there was a significant negative correlation between P300 latency and DHEA levels; (4 for females aged 50 to 59 IGFBP-3 significantly associated negatively with prolonged P300 latency; (5 for females at all age periods, estrogen and progesterone were uncorrelated with P300 latency; and (6 for females aged 40 to 69, there was significant negative correlation between DHEA levels and P300 latency. Moreover there were no statistically significant correlations between any hormone and Wechsler Memory Scale-III (WMS-111. However, in females, there was a significant positive correlation between estrogen levels and the number of Attention Deficit Disorder (ADD complaints. Conclusion Given certain caveats including confounding factors involving psychiatric and other chronic diseases as well as medications, the results may still have important value. If these results could be confirmed in a more rigorously controlled investigation, it may have important value in the diagnosis, prevention and treatment of cognitive impairments and decline.

  14. Dynamic pelvic floor MR imaging at 3 T in patients with clinical signs of urinary incontinence-preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Morakkabati-Spitz, Nuschin; Willinek, Winfried A.; Traeber, Frank; Jaeger, Ursula; Schild, Hans H. [University of Bonn, Department of Radiology, Bonn (Germany); Gieseke, Juergen [University of Bonn, Department of Radiology, Bonn (Germany); Philips Medical Systems, Best (Netherlands); Bastian, Patrick J. [University of Munich, Department of Urology, Munich (Germany); Schmitz, Bettina; Mueller, Stefan C. [University of Bonn, Department of Urology, Bonn (Germany)

    2008-11-15

    To prospectively evaluate feasibility, image quality and diagnostic accuracy of dynamic MR imaging the pelvic floor at 3.0 T in patients with urinary incontinence and to compare these results with those of MRI performed at 1.5 T. Ten patients with the diagnosis of urinary incontinence (clinical symptoms, clinical examination, pelvic ultrasound) were examined with a dynamic balanced FFE (B-FFE) sequence at 1.5 T and 3.0 T on the same day in a randomized order. Spatial (1.5 x 1.5 x 8 mm) and temporal (0.44 s) resolution at 3.0 T were comparable to the 1.5-T B-FFE sequence. Two radiologists assessed visual signal to noise (three-point scale), artefact level (five-point scale) and final MR diagnoses with regard to pelvic floor weakness (independent analysis). The diagnoses obtained at 1.5-T field strength and the results of the clinical tests served as standard of reference. In addition, ROI-based quantitative measurements were performed to assess different tissue contrasts at both field strengths. Data were analyzed for statistical differences by using the Wilcoxon's matched pairs test and the marginal homogeneity test. Visual signal to noise was rated higher at 3.0 T for all ten studies by both radiologists. With regard to artefact level, there was no statistically significant difference between the studies obtained at 3.0 T as compared to the corresponding 1.5-T studies (marginal homogeneity test: p = 0.18 for reviewer 1 and 0.41 for reviewer 2). Mean artefact level was rated minor to moderate by both reviewers for both field strengths (excellent interobserver agreement with Kendall-W value of 0.973). Except for a higher tissue contrast between fat and urethra at 1.5 T, there were no statistically significant differences between tissue contrast at 1.5 T as compared to 3.0 T (Wilcoxon's test). Final MR diagnoses regarding pelvic floor weakness did not differ between 3.0-T and 1.5-T field strength and correlated well with the results of the clinical tests

  15. Application of an aviation model of incident reporting and investigation to the neurosurgical scenario: method and preliminary data.

    Science.gov (United States)

    Ferroli, Paolo; Caldiroli, Dario; Acerbi, Francesco; Scholtze, Maurizio; Piro, Alfonso; Schiariti, Marco; Orena, Eleonora F; Castiglione, Melina; Broggi, Morgan; Perin, Alessandro; DiMeco, Francesco

    2012-11-01

    Incident reporting systems are universally recognized as important tools for quality improvement in all complex adaptive systems, including the operating room. Nevertheless, introducing a safety culture among neurosurgeons is a slow process, and few studies are available in the literature regarding the implementation of an incident reporting system within a neurosurgical department. The authors describe the institution of an aviation model of incident reporting and investigation in neurosurgery, focusing on the method they have used and presenting some preliminary results. In 2010, the Inpatient Safety On-Board project was developed through cooperation between a team of human factor and safety specialists with aviation backgrounds (DgSky team) and the general manager of the Fondazione Istituto Neurologico Carlo Besta. In 2011, after specific training in safety culture, the authors implemented an aviation-derived prototype of incident reporting within the Department of Neurosurgery. They then developed an experimental protocol to track, analyze, and categorize any near misses that happened in the operating room. This project officially started in January 2012, when a dedicated team of assessors was established. All members of the neurosurgical department were asked to report near misses on a voluntary, confidential, and protected form (Patient Incident Reporting System form, Besta Safety Management Programme). Reports were entered into an online database and analyzed by a dedicated team of assessors with the help of a facilitator, and an aviation-derived root cause analysis was performed. Since January 2012, 14 near misses were analyzed and classified. The near-miss contributing factors were mainly related to human factors (9 of 14 cases), technology (1 of 14 cases), organizational factors (3 of 14 cases), or procedural factors (1 of 14 cases). Implementing an incident reporting system is quite demanding; the process should involve all of the people who work within

  16. 3D–2D registration in mobile radiographs: algorithm development and preliminary clinical evaluation.

    Science.gov (United States)

    Otake, Yoshito; Wang, Adam S; Uneri, Ali; Kleinszig, Gerhard; Vogt, Sebastian; Aygun, Nafi; Lo, Sheng-fu L; Wolinsky, Jean-Paul; Gokaslan, Ziya L; Siewerdsen, Jeffrey H

    2015-03-07

    An image-based 3D-2D registration method is presented using radiographs acquired in the uncalibrated, unconstrained geometry of mobile radiography. The approach extends a previous method for six degree-of-freedom (DOF) registration in C-arm fluoroscopy (namely 'LevelCheck') to solve the 9-DOF estimate of geometry in which the position of the source and detector are unconstrained. The method was implemented using a gradient correlation similarity metric and stochastic derivative-free optimization on a GPU. Development and evaluation were conducted in three steps. First, simulation studies were performed that involved a CT scan of an anthropomorphic body phantom and 1000 randomly generated digitally reconstructed radiographs in posterior-anterior and lateral views. A median projection distance error (PDE) of 0.007 mm was achieved with 9-DOF registration compared to 0.767 mm for 6-DOF. Second, cadaver studies were conducted using mobile radiographs acquired in three anatomical regions (thorax, abdomen and pelvis) and three levels of source-detector distance (~800, ~1000 and ~1200 mm). The 9-DOF method achieved a median PDE of 0.49 mm (compared to 2.53 mm for the 6-DOF method) and demonstrated robustness in the unconstrained imaging geometry. Finally, a retrospective clinical study was conducted with intraoperative radiographs of the spine exhibiting real anatomical deformation and image content mismatch (e.g. interventional devices in the radiograph that were not in the CT), demonstrating a PDE = 1.1 mm for the 9-DOF approach. Average computation time was 48.5 s, involving 687 701 function evaluations on average, compared to 18.2 s for the 6-DOF method. Despite the greater computational load, the 9-DOF method may offer a valuable tool for target localization (e.g. decision support in level counting) as well as safety and quality assurance checks at the conclusion of a procedure (e.g. overlay of planning data on the radiograph for verification of the surgical product

  17. 3D-2D registration in mobile radiographs: algorithm development and preliminary clinical evaluation

    Science.gov (United States)

    Otake, Yoshito; Wang, Adam S.; Uneri, Ali; Kleinszig, Gerhard; Vogt, Sebastian; Aygun, Nafi; Lo, Sheng-fu L.; Wolinsky, Jean-Paul; Gokaslan, Ziya L.; Siewerdsen, Jeffrey H.

    2015-03-01

    An image-based 3D-2D registration method is presented using radiographs acquired in the uncalibrated, unconstrained geometry of mobile radiography. The approach extends a previous method for six degree-of-freedom (DOF) registration in C-arm fluoroscopy (namely ‘LevelCheck’) to solve the 9-DOF estimate of geometry in which the position of the source and detector are unconstrained. The method was implemented using a gradient correlation similarity metric and stochastic derivative-free optimization on a GPU. Development and evaluation were conducted in three steps. First, simulation studies were performed that involved a CT scan of an anthropomorphic body phantom and 1000 randomly generated digitally reconstructed radiographs in posterior-anterior and lateral views. A median projection distance error (PDE) of 0.007 mm was achieved with 9-DOF registration compared to 0.767 mm for 6-DOF. Second, cadaver studies were conducted using mobile radiographs acquired in three anatomical regions (thorax, abdomen and pelvis) and three levels of source-detector distance (~800, ~1000 and ~1200 mm). The 9-DOF method achieved a median PDE of 0.49 mm (compared to 2.53 mm for the 6-DOF method) and demonstrated robustness in the unconstrained imaging geometry. Finally, a retrospective clinical study was conducted with intraoperative radiographs of the spine exhibiting real anatomical deformation and image content mismatch (e.g. interventional devices in the radiograph that were not in the CT), demonstrating a PDE = 1.1 mm for the 9-DOF approach. Average computation time was 48.5 s, involving 687 701 function evaluations on average, compared to 18.2 s for the 6-DOF method. Despite the greater computational load, the 9-DOF method may offer a valuable tool for target localization (e.g. decision support in level counting) as well as safety and quality assurance checks at the conclusion of a procedure (e.g. overlay of planning data on the radiograph for verification of

  18. Simultaneous PET/MR head–neck cancer imaging: Preliminary clinical experience and multiparametric evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Covello, M., E-mail: echoplanare@gmail.com [IRCCS SDN, Via E. Gianturco, 111-113 – 80143, Naples (Italy); Cavaliere, C.; Aiello, M.; Cianelli, M.S. [IRCCS SDN, Via E. Gianturco, 111-113 – 80143, Naples (Italy); Mesolella, M.; Iorio, B. [Department of Otorhinolaryngoiatry, Federico II University, Naples (Italy); Rossi, A.; Nicolai, E. [IRCCS SDN, Via E. Gianturco, 111-113 – 80143, Naples (Italy)

    2015-07-15

    Highlights: • Simultaneous PET/MRI is a suitable tool for head/neck T-staging. • No significant differences have been found for PET measures get by both PET/CT and PET/MRI. • SUV 2D and 3D measures in HN lesion offer comparable estimations. • Multiparametric evaluation allows a complete characterization of HN lesions. - Abstract: Purpose: To evaluate the role of simultaneous hybrid PET/MR imaging and to correlate metabolic PET data with morpho-functional parameters derived by MRI in patients with head–neck cancer. Methods: Forty-four patients, with histologically confirmed head and neck malignancy (22 primary tumors and 22 follow-up) were studied. Patients initially received a clinical exam and endoscopy with direct biopsy. Next patients underwent whole body PET/CT followed by PET/MR of the head/neck region. PET and MRI studies were separately evaluated by two blinded groups (both included one radiologist and one nuclear physician) in order to define the presence or absence of lesions/recurrences. Regions of interest (ROIs) analysis was conducted on the primary lesion at the level of maximum size on metabolic (SUV and MTV), diffusion (ADC) and perfusion (K{sup trans}, V{sub e}, k{sub ep} and iAUC) parameters. Results: PET/MR examinations were successfully performed on all 44 patients. Agreement between the two blinded groups was found in anatomic allocation of lesions by PET/MR (Primary tumors: Cohen's kappa 0.93; Follow-up: Cohen's kappa 0.89). There was a significant correlation between CT-SUV measures and MR (e.g., CT-SUV VOI vs. MR-SUV VOI: ρ = 0.97, p < 0.001 for the entire sample). There was also significant positive correlations between the ROI area, SUV measures, and the metabolic parameters (SUV and MTV) obtained during both PET/CT and PET/MR. A significant negative correlation was observed between ADC and K{sup trans} values in the primary tumors. In addition, a significant negative correlation existed between MR SUV and ADC in

  19. Clinical Investigations

    Science.gov (United States)

    1977-09-30

    Pregnancy with Fetal Intrauteri-ne Death, Missed Abortion or Hydatidiform ... 54 Work Unit No. 76/17 (FY76, T) The Effect of Uterine Blood Flow on...79920 DETAIL SHEET Prostaglandin E2, Efficacy Study for Termination of Pregnancy with TITLE: Fetal Intrauterine Death, Missed Abortion or Hydatidiform...Cryptococcus neoformans strains ............................. 19 Work Unit No. 75/27 (Fy74, C) Assessment of Ilediation Factors Involved in Chemical Pain

  20. Metacognition and negative emotions in clinical practice. A preliminary study with patients with bowel disorder

    Directory of Open Access Journals (Sweden)

    Vittorio Lenzo

    2013-09-01

    Full Text Available In the past few years psychological characteristics in patients with organic bowel disorder have been poorly considered. However recent studies underline that psychological features increase gastrointestinal symptoms. The aim of this study is to investigate metacognition and emotions in patients with organic bowel disorder and functional bowel disorder. 33 outpatients with organic diagnosis and 28 outpatients with functional diagnosis were assessed with MCQ-30, ANPS and Brief-Cope; moreover stress was evaluated in all outpatients.  Results revealed that two groups show the same psychological disturbances and there are no differences between organic patients and functional patients. Statistical analysis indicated significant relations between dysfunctional metacognitive beliefs and negative emotions. Specifically, Beliefs of Uncontrollability and Danger (UD are significantly related to Fear, Anger and Sadness. Moreover Fear and Anger are significantly related to stress; dysfunctional metacognitive beliefs are related to coping strategies. Beliefs of UD are related to Using Emotional Support; Positive Beliefs (PB are related to Planning, while Cognitive Confidence (CC is related to Self-Blame. Unexpectedly results are higher in patients with organic diagnosis. Our results suggest to reconsider psychological influences in patients with organic diagnosis of gastrointestinal disease. Keywords:Metacognition; Inflammatory bowel diseases; Functional gastrointestinal disorders; Emotions; Coping; 

  1. Smoking cessation intervention within the framework of a lung cancer screening program: preliminary results and clinical perspectives from the "Cosmos-II" Trial.

    Science.gov (United States)

    Filippo, Lococo; Principe, Rosastella; Cesario, Alfredo; Apolone, Giovanni; Carleo, Francesco; Ialongo, Pasquale; Veronesi, Giulia; Cardillo, Giuseppe

    2015-02-01

    Data coming from the literature investigating the effectiveness and interaction between smoking cessation (SC) and lung cancer screening (LCScr) are still sparse and inconsistent. Herein, we report the preliminary results from the ongoing lung cancer screening trial ("Cosmos-II") focusing our analysis on the inter-relationship between the SC program and the LCScr.

  2. Nimotuzumab combined with radiotherapy for esophageal cancer: preliminary study of a Phase II clinical trial

    Directory of Open Access Journals (Sweden)

    Liang J

    2013-11-01

    Full Text Available Jun Liang,1 Mingyan E,2 Gang Wu,3 Lujun Zhao,4 Xia Li,5 Xia Xiu,6 Ning Li,1 Bo Chen,1 Zhouguang Hui,1 Jima Lv,1 Hui Fang,1 Yu Tang,1 Nan Bi,1 Wenqing Wang,1 Yirui Zhai,1 Tao Li,1 Dongfu Chen,1 Shuangmei Zou,7 Ning Lu,7 Rolando Perez-Rodríguez,8 Junqi Zheng,9 Luhua Wang11Department of Radiotherapy, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China; 2Department of Radiotherapy, Cancer Hospital of Harbin Medical University, Harbin, People's Republic of China; 3Department of Radiotherapy, Tongji Cancer Center Hospital, Wuhan, People's Republic of China; 4Department of Radiotherapy, Cancer Hospital of Tianjin Medical University, Tianjin, People's Republic of China; 5Department of Radiotherapy, LiaoNing Province Cancer Hospital, Shenyang, People's Republic of China; 6Department of Radiotherapy, Beijing Hospital, Beijing, People's Republic of China; 7Department of Pathology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China; 8Center of Molecular Immunology, Havana, Cuba; 9School of Medicine, Tongji University, Shanghai, People's Republic of ChinaObjective: To determine the safety and therapeutic effects of nimotuzumab (h-R3 combined with radiotherapy in esophageal cancer.Methods: This Phase II clinical trial involved 42 patients with stage II (inoperable or refused surgery to stage IV (supraclavicular lymph node metastasis only esophageal cancers treated between November 2008 and July 2010. All patients had squamous cell carcinomas, and all received three-dimensional conformal radiotherapy and 200 mg nimotuzumab per week during radiotherapy.Results: There were 9, 25, and 8 patients with stage II, III and IV disease, respectively. All except two patients received 50–70 Gy radiation; 37 patients (88.1% received more than five nimotuzumab doses. Grade III toxicities (21.4% of all adverse events included esophagitis and gastrointestinal, dermatological and hematological

  3. Mass spectrometry-based proteomics and analyses of serum: a primer for the clinical investigator.

    Science.gov (United States)

    Fusaro, V A; Stone, J H

    2003-01-01

    The vocabulary of proteomics and the swiftly-developing, technological nature of the field constitute substantial barriers to clinical investigators. In recent years, mass spectrometry has emerged as the most promising technique in this field. The purpose of this review is to introduce the field of mass spectrometry-based proteomics to clinical investigators, to explain many of the relevant terms, to introduce the equipment employed in this field, and to outline approaches to asking clinical questions using a proteomic approach. Examples of clinical applications of proteomic techniques are provided from the fields of cancer and vasculitis research, with an emphasis on a pattern recognition approach.

  4. Comparative clinical and haematological investigations in lactating cows with subclinical and clinical ketosis

    Directory of Open Access Journals (Sweden)

    Vania Marutsova

    2015-10-01

    Full Text Available Ketosis of lactating cows is among the most common metabolic diseases in modern dairy farms. The economic importance of the disease is caused by the reduced milk yield and body weight loss, poor feed conversion, lower conception rates, culling and increased mortality of affected animals. In the present study, a total of 47 high-yielding dairy cows up to 45 days in milk (DIM are included. All animals were submitted to physical examination wich included checking the rectal body temperature, heart rate, respiratory and rumen contraction rates, and inspection of visible mucous coats. The body condition was scored, and blood β-hydroxybutyrate (BHBA concentrations were assayed. The cows were divided into 3 groups: first group (control (n=24 with blood β-hydroxybutyrate level 2.6 mmol/l (clinical ketosis. Whole blood samples were obtained and analyzed for Red Blood Cell (RBC, 1012/l, Hemoglobin (HGB, g/l, Hematocrit (HCT, %, Mean Corpuscular Volume (MCV, fl, Mean Corpuscular Hemoglobin (MCH, pg, Mean Corpuscular Hemoglobin Concentration (MCHC, g/l, White Blood Cell (WBC, 109/l, Lymphocytes (LYM, 109/l, Monocytes (MON, 109/l, Granulocytes (GRA, 109/l, Red Blood Distribution Width (RDW, %, Red Blood Cell Distribution Width Absolute (RDWa, fl, Platelets (PLT, 109/l and Mean Platelet Volume (MPV, fl. In this study, deviations in the clinical parameters in the control group and in those with subclinical ketosis were not identified. The cows from the third group (clinical ketosis exhibited hypotonia, anorexia and body weight loss vs. control group. Hematological analysis showed leukocytosis and lymphocytosis in cows with subclinical ketosis vs. control group. In cows with clinical ketosis WBC counts decreased (leukopenia, while hemoglobin content and hematocrit values are higher vs. control group. Blood BHBA values are higher in both groups of ketotic cows vs. the control group. The other analyzed parameters (RBC, MCH, MCHC, MCV, RDW, RDWa, MON, GRA, PLT

  5. 59th Medical Wing Clinical Research Division Clinical Investigations Program Posters (Count: 2)

    Science.gov (United States)

    2017-05-08

    publication, the 59th Clinical Research Division may pay for your basic journal publishing charges (to include costs for tables and black and white photos...Health Sciences Education (GHSE) {SGS O&M); SGS R&D; Tri-Service Nursing Research Program (TSNRP): Defense Medical Research & Development Program (DMRDP...should be accomplished no later than 30 days before final clearance is required to publish/present your materials. If you have any questions or

  6. Cost and effectiveness of clinical investigation: the state of the art.

    Science.gov (United States)

    Clarke, R M; Mason, B; Leeder, S R

    1980-10-01

    Clinical investigation by means of special technical tests has increased in clinical practice during recent years. Pressures causing this increase are said to include: rapid technological change making many more tests available, clinical uncertainty, peer pressure, greater patient awareness, and concern for diagnostic completeness. Cost factors do not appear to have influenced test-ordering behaviour to any large extent, and those ordering investigations are frequently ignorant of the cost of the test which they are ordering, both to the patient and the community. The relation of clinical investigational activity to quality of outcome of patient care remains largely unestablished. Studies of the possible modification of test-ordering behaviour through educational and institutional policy pressures are reviewed. A rational approach to investigating the effectiveness of techniques designed to encourage the more economic and effective use of investigations is presented in brief on the basis of this review of previously published work.

  7. Bridging clinical investigators and statisticians: writing the statistical methodology for a research proposal.

    Science.gov (United States)

    Adams-Huet, Beverley; Ahn, Chul

    2009-12-01

    Clinical investigators often find the thought of writing the statistical analysis plan daunting. Early collaboration between the clinical investigator and statistician can improve the study design and validity of the results by developing the statistical methodology that specifically addresses the research hypothesis. With the clinical investigator, a statistician often writes the statistical methods section that includes sample size and power analyses, randomization and blinding procedures, interim analysis, and data monitoring plans, in addition to the statistical analysis plan. To make this process less mysterious, we describe how the statistical methods section is developed in collaboration with a statistician.

  8. Acute lung injury and acute respiratory distress syndrome: experimental and clinical investigations

    Institute of Scientific and Technical Information of China (English)

    Hsing I Chen

    2011-01-01

    Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) can be associated with various disorders.Recent investigation has involved clinical studies in collaboration with clinical investigators and pathologists on the pathogenetic mechanisms of ALl or ARDS caused by various disorders.This literature review includes a brief historical retrospective of ALI/ARDS, the neurogenic pulmonary edema due to head injury, the long-term experimental studies and clinical investigations from our laboratory, the detrimental role of NO, the risk factors, and the possible pathogenetic mechanisms as well as therapeutic regimen for ALI/ARDS.

  9. Analysing spatial trends in referral patterns to cancer genetics services: a preliminary investigation of regional variations in Wales.

    Science.gov (United States)

    McDonald, Kevin; Higgs, Gary; Iredale, Rachel; Tempest, Vanessa; Gray, Jonathon

    2004-11-01

    This paper discusses spatial trends in referral patterns to a cancer genetics service. It presents a literature review outlining the paucity of existing research, a preliminary analysis at the Unitary Authority level in Wales and advances a programme of further research to be conducted at a more detailed spatial level. The preliminary analysis shows a weak negative relationship between referral rates from primary care and social deprivation by Unitary Authority (Spearman rank correlation coefficient, sigma = -0.38). There is also a weak positive relationship between average settlement size and referral rates (sigma = +0.28), which taken together may indicate that primary care practices in affluent urban areas are more likely to refer than those in poorer rural areas. Future research will be conducted at a finer spatial scale, and will take into account characteristics of primary care practices and the patients being referred, amongst other variables.

  10. Applicable or non-applicable: investigations of clinical heterogeneity in systematic reviews

    Directory of Open Access Journals (Sweden)

    Laura E. Chess

    2016-02-01

    Full Text Available Abstract Background Clinical heterogeneity can be defined as differences in participant characteristics, types or timing of outcome measurements and intervention characteristics. Clinical heterogeneity in systematic reviews has the possibility to significantly affect statistical heterogeneity leading to inaccurate conclusions and misled decision making. The aim of this study is to identify to what extent investigators are assessing clinical heterogeneity in both Cochrane and non-Cochrane systematic reviews. Methods The most recent 100 systematic reviews from the top five journals in medicine—JAMA, Archives of Internal Medicine, British Medical Journal, The Lancet, and PLOS Medicine—and the 100 most recently published and/or updated systematic reviews from Cochrane were collected. Various defined items of clinical heterogeneity were extracted from the included reviews. Investigators used chi-squared tests, logarithmic modeling and linear regressions to determine if the presence of such items served as a predictor for clinical heterogeneity when comparing Cochrane to non-Cochrane reviews. Extracted variables include number of studies, number of participants, presence of quantitative synthesis, exploration of clinical heterogeneity, heterogeneous characteristics explored, basis and methods used for investigating clinical heterogeneity, plotting/visual aids, author contact, inferences from clinical heterogeneity investigation, reporting assessment, and the presence of a priori or post-hoc analysis. Results A total of 317 systematic reviews were considered, of which 199 were in the final analysis. A total of 81 % of Cochrane reviews and 90 % of non-Cochrane reviews explored characteristics that are considered aspects of clinical heterogeneity and also described the methods they planned to use to investigate the influence of those characteristics. Only 1 % of non-Cochrane reviews and 8 % of Cochrane reviews explored the clinical

  11. Investigators' viewpoint of clinical trials in India: Past, present and future.

    Science.gov (United States)

    Mallath, Mohandas K; Chawla, Tanuj

    2017-01-01

    India's success in producing food and milk for its population (Green Revolution and White Revolution) happened because of scientific research and field trials. Likewise improving the health of Indians needs clinical research and clinical trials. A Large proportion of the sick Indians are poor, illiterate with no access to good health care. They are highly vulnerable to inducement and exploitation in clinical trials. The past two decades saw the rise and fall of clinical trials in India. The rise happened when our regulators created a favorable environment, and Indian investigators were invited to participate in global clinical trials. The gap between the demand and supply resulted in inadequate protection of the trial participants. Reports of abuses of the vulnerable trial participants followed by public interest litigations led to strengthening of regulations by the regulators. The stringent new regulations made the conduct of clinical trials more laborious and increased the cost of clinical trials in India. There was a loss of interest in sponsored clinical trials resulting in the fall in global clinical trials in India. Following repeated appeals by the investigators, the Indian regulators have recently relaxed some of the stringent regulations, while continuing to ensure the adequate patient protection. Clinical trials that are relevant to our population and conducted by well-trained investigators and monitored by trained and registered Ethics Committees will increase in the future. We must remain vigilant, avoid previous mistakes, and strive hard to protect the trial participants in the future trials.

  12. Investigators' viewpoint of clinical trials in India: Past, present and future

    Science.gov (United States)

    Mallath, Mohandas K.; Chawla, Tanuj

    2017-01-01

    India's success in producing food and milk for its population (Green Revolution and White Revolution) happened because of scientific research and field trials. Likewise improving the health of Indians needs clinical research and clinical trials. A Large proportion of the sick Indians are poor, illiterate with no access to good health care. They are highly vulnerable to inducement and exploitation in clinical trials. The past two decades saw the rise and fall of clinical trials in India. The rise happened when our regulators created a favorable environment, and Indian investigators were invited to participate in global clinical trials. The gap between the demand and supply resulted in inadequate protection of the trial participants. Reports of abuses of the vulnerable trial participants followed by public interest litigations led to strengthening of regulations by the regulators. The stringent new regulations made the conduct of clinical trials more laborious and increased the cost of clinical trials in India. There was a loss of interest in sponsored clinical trials resulting in the fall in global clinical trials in India. Following repeated appeals by the investigators, the Indian regulators have recently relaxed some of the stringent regulations, while continuing to ensure the adequate patient protection. Clinical trials that are relevant to our population and conducted by well-trained investigators and monitored by trained and registered Ethics Committees will increase in the future. We must remain vigilant, avoid previous mistakes, and strive hard to protect the trial participants in the future trials.

  13. Investigators' viewpoint of clinical trials in India: Past, present and future

    Directory of Open Access Journals (Sweden)

    Mohandas K Mallath

    2017-01-01

    Full Text Available India's success in producing food and milk for its population (Green Revolution and White Revolution happened because of scientific research and field trials. Likewise improving the health of Indians needs clinical research and clinical trials. A Large proportion of the sick Indians are poor, illiterate with no access to good health care. They are highly vulnerable to inducement and exploitation in clinical trials. The past two decades saw the rise and fall of clinical trials in India. The rise happened when our regulators created a favorable environment, and Indian investigators were invited to participate in global clinical trials. The gap between the demand and supply resulted in inadequate protection of the trial participants. Reports of abuses of the vulnerable trial participants followed by public interest litigations led to strengthening of regulations by the regulators. The stringent new regulations made the conduct of clinical trials more laborious and increased the cost of clinical trials in India. There was a loss of interest in sponsored clinical trials resulting in the fall in global clinical trials in India. Following repeated appeals by the investigators, the Indian regulators have recently relaxed some of the stringent regulations, while continuing to ensure the adequate patient protection. Clinical trials that are relevant to our population and conducted by well-trained investigators and monitored by trained and registered Ethics Committees will increase in the future. We must remain vigilant, avoid previous mistakes, and strive hard to protect the trial participants in the future trials.

  14. Safety and preliminary immunogenicity of Cuban pneumococcal conjugate vaccine candidate in healthy children: a randomized phase I clinical trial.

    Science.gov (United States)

    Dotres, Carlos P; Puga, Rinaldo; Ricardo, Yariset; Broño, Carmen R; Paredes, Beatriz; Echemendía, Vladimir; Rosell, Sandra; González, Nadezhda; García-Rivera, Dagmar; Valdés, Yury; Goldblatt, David; Vérez-Bencomo, Vicente

    2014-09-15

    A new heptavalent conjugate vaccine (PCV7-TT) is under development in Cuba. PCV7-TT contains 2 μg of serotypes 1, 5, 14, 18C, 19F, 23F and 4 μg of 6B, each one conjugated to tetanus toxoid (TT). This vaccine was designed with the serotypes that cause most invasive pneumococcal diseases (IPD) worldwide. In the present study, we investigated the safety and explored the immunogenicity of PCV7-TT during a controlled, randomized and double blind clinical trial phase I in 4-5-year-old children. PCV7-TT was well tolerated and as safe as Synflorix used as control vaccine. Following a single-dose vaccination, all individual serotypes included in PCV7-TT induced statistically significant increase of IgG GMC and OPA GMT. These are the first clinical results of PCV7-TT in children and they pave the way toward next clinical trials in children and infants. This clinical trial was published in the Cuban Public Register of Clinical Trials with code RPCEC00000173.

  15. Preliminary investigation of the effect of air-pollution-control residue from waste incineration on the properties of cement paste and mortar

    DEFF Research Database (Denmark)

    Geiker, Mette Rica; Kjeldsen, Ane Mette; Galluci, Emmanuel

    2006-01-01

    For preliminary assessment of the engineering properties of concrete with air-pollution-control residue from waste incineration (APC) the possible reactivity of APC and the effect of APC on cement hydration were investigated by isothermal calorimetry, chemical shrinkage (pychnometry), thermal...... metals (approx. 3%) the preliminary studies were performed on untreated samples to evaluate the possible application of the least expensive materials and processes. Pastes and mortars of low alkali sulphate resistant Portland cement with 0%, 10%, and 20% APC substitution were prepared. Mixes with 10......% and 20% APC showed a major retarding effect of APC on the development of hydration. The APC was found to be pozzolanic. Chemical shrinkage measurements indicated early expansive reactions of pastes with the APC including evolution of air. Crack formation was observed in mortars with APC, and strength...

  16. 乳腺专用PET临床初步应用%The preliminary clinical application of MAMMI dedicated breast PET

    Institute of Scientific and Technical Information of China (English)

    鲍晓; 姚之丰; 张勇平; 章英剑; 胡四龙; 程竞仪; 杨忠毅; 刘帅; 刘芮; 孙艺斐; 王思阳; 刘畅

    2015-01-01

    Objective:To evaluate the preliminary clinical application value of MAMMI dedicated breast PET.Methods:A total of 76 patients with positive breast lesions on whole-body18F-lfuorodeoxyglucose (18F-FDG) PET/CT or suspicious occult breast cancer voluntarily underwent MAMMI PET in prone position after whole-body18F-FDG PET/CT. The maximal standardized uptake values (SUVmax) were compared according to lesion size, ultrasound grading and molecular subtype of breast cancer. Results:MAMMI PET visualized 63 lesions in 48 patients with speciifc pathologic diagnosis. The smallest lesion was 0.3 cm indiameter. Malignant lesions were classiifed into 3 groups based on diameter as follows: grade 1, 1 cm or smaller; grade 2, 1 to 2 cm; and grad 3, larger than 2 cm. The mean values of SUVmax of them were 4.58 ±2.01, 7.51 ±3.10 and 11.27±5.29, respectively, and there were signiifcant differences in SUVmax through pairwise comparison (P2 cm时,SUVmax平均值分别为4.58±2.01、7.51±3.10和11.27±5.29,两两比较差异均有统计学意义(P<0.01或P<0.05);乳腺影像报告和数据系统(BI-RADS)4级与5级之间SUVmax差异也有统计学意义(P<0.05);各分子亚型之间SUVmax差异无统计学意义。结论:乳腺专用PET对探测乳腺小病灶、多中心、多原发病灶具有很好的临床应用价值。

  17. Blood pressure changes in African American patients receiving chiropractic care in a teaching clinic: a preliminary study

    National Research Council Canada - National Science Library

    McMasters, Kim L; Wang, Joe; York, Jennifer; Hart, John; Neely, Cheneir; Delain, Rochelle J

    2013-01-01

    The purpose of this preliminary study was to determine if a course of chiropractic care would change blood pressure measurements in African American patients and to determine if a study was feasible...

  18. Risk groups for clinical complications of norovirus infections: an outbreak investigation.

    NARCIS (Netherlands)

    Mattner, F; Sohr, D; Heim, A; Gastmeier, P; Vennema, H; Koopmans, M

    2006-01-01

    Norovirus infections have been described as self-limiting diseases of short duration. An investigation of a norovirus outbreak in a university hospital provided evidence for severe clinical features in patients with several underlying diseases. Clinical outcomes of norovirus infection were defined.

  19. 76 FR 50484 - Draft Guidance for Industry, Clinical Investigators, and Food and Drug Administration Staff...

    Science.gov (United States)

    2011-08-15

    ... Considerations for Pivotal Clinical Investigations for Medical Devices.'' This document is intended to provide... medical devices and for FDA staff who review those submissions. This guidance document describes different study design principles relevant to the development of medical device clinical studies that can be...

  20. Crime Scene Investigation: Clinical Application of Chemical Shift Imaging as a Problem Solving Tool

    Science.gov (United States)

    2016-02-26

    MDW/SGVU SUBJECT: Professional Presentation Approva l 26 FEB 2016 1. Your paper, entitled Crime Scene Investigation: Clinical Aoolication of...or technical information as a publication/presentation, a new 59 MDW Form 3039 must be submitted for review and approval.] Crime Scene Investiga...tion: Clinical Application of Chemical Shift Imaging as a Problem Solving Tool 1. TITLE OF MATERIAL TO BE PUBLISHED OR PRESENTED Crime Scene

  1. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in surgical patients

    DEFF Research Database (Denmark)

    Schulman, S; Angerås, U; Bergqvist, D

    2010-01-01

    The definition of major bleeding varies between studies on surgical patients, particularly regarding the criteria for surgical wound-related bleeding. This diversity contributes to the difficulties in comparing data between trials. The Scientific and Standardization Committee (SSC), through its...... subcommittee on Control of Anticoagulation, of the International Society on Thrombosis and Haemostasis has previously published a recommendation for a harmonized definition of major bleeding in non-surgical studies. That definition has been adopted by the European Medicines Agency and is currently used...... in several non-surgical trials. A preliminary proposal for a parallel definition for surgical studies was presented at the 54(th) Annual Meeting of the SSC in Vienna, July 2008. Based on those discussions and further consultations with European and North American surgeons with experience from clinical trials...

  2. Integration einer OSCE in das zahnmedizinische Physikum [Integration of an Objective Structured Clinical Examination (OSCE into the Dental Preliminary Exams

    Directory of Open Access Journals (Sweden)

    Ratzmann, Anja

    2012-02-01

    Full Text Available [english] Introduction: In the pre-clinical phase of the study of dentistry at the University of Greifswald, the course “Early Patient Contact (EPC” is conducted within the framework of Community Medicine/Dentistry. The course is based on three pillars: the patient visiting program, special problem-oriented seminars, and communication training for doctors. The essential goal consists of providing students with real patient contact right at the beginning of their study of dentistry, thus making the study of dentistry patient-based very early on. Students are trained in taking comprehensive anamneses and recording clinical findings.Methods: Within the framework of the dental preliminary exams, the course is evaluated using an OSCE on a standardized patient. Furthermore, the added value of an additional training unit (conducting anamnesis and clinical examination in preparation for the OSCE was evaluated. The exam results of a group without training (control group were compared with those of a group with training (intervention group.Results: The intervention group performed significantly better than the control on the following items: the total number of points achieved on the OSCE early patient contact, and in the most important points of the anamnesis and clinical examination. In addition, the intervention group tended to score higher in terms of the item “oral health status”.Conclusion: The present study showed a positive effect of an additional training unit on students’ performance in the OSCE. Taking the limitations of the study and the results of a literature review into account, we recommend conducting such training as preparation for the OSCE.[german] Einleitung: An der Universität Greifswald wird im vorklinischen Abschnitt des Studienganges der Zahnmedizin im Rahmen der Community Medicine/Dentistry der Kurs „Der Frühe Patientenkontakt (FPK“ durchgeführt. Der Kurs basiert auf drei Prinzipien: dem Patientenbesuchsprogramm

  3. Technical Note: Preliminary investigations into the use of a functionalised polymer to reduce diffusion in Fricke gel dosimeters

    Energy Technology Data Exchange (ETDEWEB)

    Smith, S. T., E-mail: s164.smith@qut.edu.au; Masters, K.-S.; Hosokawa, K.; Blinco, J. P.; Trapp, J. V. [School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane 4000 (Australia); Crowe, S. B. [School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane 4000, Australia and Cancer Care Services, Royal Brisbane and Women’s Hospital, Brisbane 4006 (Australia); Kairn, T. [School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane 4000, Australia and Genesis Cancer Care Queensland, Brisbane 4066 (Australia)

    2015-12-15

    Purpose: A modification of the existing PVA-FX hydrogel has been made to investigate the use of a functionalised polymer in a Fricke gel dosimetry system to decrease Fe{sup 3+} diffusion. Methods: The chelating agent, xylenol orange, was chemically bonded to the gelling agent, polyvinyl alcohol (PVA) to create xylenol orange functionalised PVA (XO-PVA). A gel was created from the XO-PVA (20% w/v) with ferrous sulfate (0.4 mM) and sulfuric acid (50 mM). Results: This resulted in an optical density dose sensitivity of 0.014 Gy{sup −1}, an auto-oxidation rate of 0.0005 h{sup −1}, and a diffusion rate of 0.129 mm{sup 2} h{sup −1}; an 8% reduction compared to the original PVA-FX gel, which in practical terms adds approximately 1 h to the time span between irradiation and accurate read-out. Conclusions: Because this initial method of chemically bonding xylenol orange to polyvinyl alcohol has inherently low conversion, the improvement on existing gel systems is minimal when compared to the drawbacks. More efficient methods of functionalising polyvinyl alcohol with xylenol orange must be developed for this system to gain clinical relevance.

  4. [THE RESULTS OF CLINICAL AND PSYCHOPATHOLOGICAL AND PSYCHOLOGICAL DIAGNOSTIC INVESTIGATIONS EMPLOYEES OF FINANCIAL INSTITUTIONS WHICH WERE IDENTIFIED NEUROTIC DISORDERS].

    Science.gov (United States)

    Solovyova, M

    2014-12-01

    The article presents the results of the clinical and psychopathological and psychological diagnostic, investigations mental health employees of financial institutions, description and analysis of clinical forms identified disorders.

  5. Preliminary investigations on the determination of three-dimensional dose distributions using scintillator blocks and optical tomography

    Energy Technology Data Exchange (ETDEWEB)

    Kroll, Florian; Karsch, Leonhard [OncoRay - National Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, TU Dresden, 01307 Dresden (Germany); Pawelke, Jörg [OncoRay - National Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, TU Dresden, 01307 Dresden, Germany and Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiation Physics, P.O. Box 510119, 01314 Dresden (Germany)

    2013-08-15

    dose profiles are in agreement with reference measurements. An inherent drawback of the scintillator is the nonlinear light output for high stopping-power radiation due to the quenching effect. It impacts the depth dose curves measured with the dosimeter. For single Bragg peak distributions this leads to a peak to plateau ratio of 2.8 instead of 4.5 for the reference ionization chamber measurement. Furthermore, the transmission of the clinical bremsstrahlung beams through the scintillator leads to the saturation of one camera, making dose reconstructions in that case presently not feasible.Conclusions: It is shown that distributions of scintillation light generated by proton or electron beams can be reconstructed by the dosimetry system within minutes. The quenching apparent for proton irradiation, and the yet not precisely determined position dependency of the imaging scale, require further investigation and corrections. Upgrading the prototype with larger or inorganic scintillators would increase the detectable proton and electron energy range. The presented results show that the determination of 3D dose distributions using scintillator blocks and optical tomography is a promising dosimetry method.

  6. The administration of psilocybin to healthy, hallucinogen-experienced volunteers in a mock-functional magnetic resonance imaging environment: a preliminary investigation of tolerability.

    Science.gov (United States)

    Carhart-Harris, Robin L; Williams, Tim M; Sessa, Ben; Tyacke, Robin J; Rich, Ann S; Feilding, Amanda; Nutt, David J

    2011-11-01

    This study sought to assess the tolerability of intravenously administered psilocybin in healthy, hallucinogen-experienced volunteers in a mock-magnetic resonance imaging environment as a preliminary stage to a controlled investigation using functional magnetic resonance imaging to explore the effects of psilocybin on cerebral blood flow and activity. The present pilot study demonstrated that up to 2 mg of psilocybin delivered as a slow intravenous injection produces short-lived but typical drug effects that are psychologically and physiologically well tolerated. With appropriate care, this study supports the viability of functional magnetic resonance imaging work with psilocybin.

  7. Preliminary results from multicenter clinical trials for detection of cervical squamous intraepithelial lesions using a novel full-field evoked-tissue-flourescence-based imaging instrument

    Science.gov (United States)

    Dattamajumdar, Anupam K.; Wells, D.; Parnell, Julie R.; Ganguly, Dipankur; Wright, Thomas C., Jr.

    2001-10-01

    We report preliminary results from a multi-center trial of evaluating the performance of a novel, full-field multi-spectral tissue fluorescence imaging system (CerviscanTM) designed to detect cervical squamous intraepithelial lesions. Spectral data from multiple regions of 48 patients enrolled from clinical performance sites in the US and Canada are included in this preliminary analysis. This includes 30 women used for the training set and 18 used for the testing set. In the testing set, 37/43 SIL and 70/80 NonSIL regions were correctly identified for a sensitivity of 86% and specificity of 87.5%. CerviscanTM locates cervical precancerous lesions with high sensitivity and specificity and has the potential to permit 'see and treat' patient management.

  8. Preliminary investigation on the prevalence of malaria and HIV co-infection in Mae Sot District, Tak Province of Thailand

    Institute of Scientific and Technical Information of China (English)

    Siwalee; Rattanapunya; Wanna; Chaijaroenkul; Jiraporn; Kuesap; Ronnatrai; Ruengweerayut; Kesara; Na-Bangchang

    2015-01-01

    Objective: To preliminarily investigate the prevalence of HIV co-infection in patients with malaria in Mae Sot District, Tak Province of Thailand.Methods: The study was a retrospective study on blood samples collected from a total of 256 patients with malaria(all species and severity) who attended Mae Tao clinic for migrant workers, Tak Province during 2005-2007(148 samples) and 2010-2012(108 samples). Malaria diagnosis was performed based on microscopic examination of patients’ blood smears. Chemiluminescent microparticle immunoassay and gel particle passive agglutination were employed for the detection of HIV antigen in patients’ plasma. Results: Plasmodium falciparum(P. falciparum) and Plasmodium vivax(P. vivax) are the two predominant malaria species with the ratio of about 1: 1 to 1.5:1. Most of the P. falciparum cases were presented with acute uncomplicated signs and symptoms with highest parasitemia of 1 045 000 asexual parasites/μL bloods. The prevalence of malaria and HIV co-infection during 2005-2007 was 1.35%(2/148 cases, 1 each for P. falciparum and P. vivax co-infection), but was increased to 2.78%(3/108 cases, 2 and 1 for P. falciparum and P. vivax co-infection, respectively) during 2010-2012.Conclusions: The increasing trend of prevalence of malaria and HIV co-infection in Mae Sot, Tak province was of a great concern on either pharmacodynamics or pharmacokinetics aspect. The study in a larger numbers of malaria patients in different endemic areas throughout the country with different time periods is underway.

  9. Preliminary investigation of an ultrasound method for estimating pressure changes in deep-positioned vessels

    DEFF Research Database (Denmark)

    Olesen, Jacob Bjerring; Villagómez Hoyos, Carlos Armando; Traberg, Marie Sand

    2016-01-01

    varying from -40 Pa to 15 Pa with a standard deviation of 32%, and a bias of 25% found relative to the peak simulated pressure drop. This preliminary study shows that pressure can be estimated non-invasively to a depth that enables cardiac scans, and thereby, the possibility of detecting the pressure......This paper presents a method for measuring pressure changes in deep-tissue vessels using vector velocity ultrasound data. The large penetration depth is ensured by acquiring data using a low frequency phased array transducer. Vascular pressure changes are then calculated from 2-D angle...... of angle-independent vector velocities are acquired using directional synthetic aperture vector flow imaging. The obtained results are evaluated by comparison to a 3-D numerical simulation model with equivalent geometry as the designed phantom. The study showed pressure drops across the constricted phantom...

  10. Preliminary investigation of biogenic gas production in Indonesian low rank coals and implications for a renewable energy source

    Science.gov (United States)

    Susilawati, Rita; Papendick, Sam L.; Gilcrease, Patrick C.; Esterle, Joan S.; Golding, Suzanne D.; Mares, Tennille E.

    2013-11-01

    Indonesia has abundant coal resources at depths suitable to contain substantial volumes of naturally occurring methane, which are currently being explored. Most Indonesian coals are thermally immature, but are composed of hydrogen-rich organic components that are presumed to make them excellent substrates for biogenic methane production. Gas isotope results from pilot wells in South Sumatra, reported in this study, are interpreted to indicate biogenic origins for the methane. Corresponding formation water samples were collected and incubated, and show the presence of indigenous microbial communities capable of producing methane from Indonesian and Australian coal. Although these results are only preliminary, they are promising and support the possibility of Indonesia developing bio renewable energy from coal seams.

  11. Preliminary investigations of Monte Carlo Simulations of neutron energy and LET spectra for fast neutron therapy facilities

    CERN Document Server

    Kroc, T K

    2012-01-01

    No fast neutron therapy facility has been built with optimized beam quality based on a thorough understanding of the neutron spectrum and its resulting biological effectiveness. A study has been initiated to provide the information necessary for such an optimization. Monte Carlo studies will be used to simulate neutron energy spectra and LET spectra. These studies will be bench-marked with data taken at existing fast neutron therapy facilities. Results will also be compared with radiobiological studies to further support beam quality optimization. These simulations, anchored by this data, will then be used to determine what parameters might be optimized to take full advantage of the unique LET properties of fast neutron beams. This paper will present preliminary work in generating energy and LET spectra for the Fermilab fast neutron therapy facility.

  12. An elasto-plastic approach to estimate lifetime of notched components under variable amplitude fatigue loading: a preliminary investigation

    Directory of Open Access Journals (Sweden)

    N. Zuhair Faruq

    2016-07-01

    Full Text Available The present paper is concerned with the formulation of an elasto-plastic strain based approach suitable for assessing fatigue strength of notched components subjected to in-service variable amplitude cyclic loading. The hypothesis is formed that the crack initiation plane is closely aligned with the plane of maximum shear strain amplitude, its orientation and the associated stress/strain quantities being determined using the Maximum Variance Method. Fatigue damage is estimated by applying the Modified Manson-Coffin Curve Method (MMCCM along with the Point Method (PM. In the proposed approach, the required critical distance is treated as a material property whose value is not affected either by the sharpness of the notch being assessed or by the profile of the load spectrum being applied. The detrimental effect of non-zero mean stresses and degree of multiaxiality of the local stress/strain histories is also considered. The accuracy and reliability of the proposed design methodology was checked against several experimental data taken from the literature and generated under different uniaxial variable amplitude load histories. In order to determine the required local stress/strain states, refined elasto-plastic finite element models were solved using commercial software ANSYS®. This preliminary validation exercise allowed us to prove that the proposed approach is capable of estimates laying within an error factor of about 2. These preliminary results are certainly promising, strongly supporting the idea that the proposed design strategy can successfully be used to assess the fatigue lifetime of notched metallic components subjected to in-service multiaxial variable amplitude loading sequences.

  13. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in surgical patients.

    Science.gov (United States)

    Schulman, S; Angerås, U; Bergqvist, D; Eriksson, B; Lassen, M R; Fisher, W

    2010-01-01

    The definition of major bleeding varies between studies on surgical patients, particularly regarding the criteria for surgical wound-related bleeding. This diversity contributes to the difficulties in comparing data between trials. The Scientific and Standardization Committee (SSC), through its subcommittee on Control of Anticoagulation, of the International Society on Thrombosis and Haemostasis has previously published a recommendation for a harmonized definition of major bleeding in non-surgical studies. That definition has been adopted by the European Medicines Agency and is currently used in several non-surgical trials. A preliminary proposal for a parallel definition for surgical studies was presented at the 54(th) Annual Meeting of the SSC in Vienna, July 2008. Based on those discussions and further consultations with European and North American surgeons with experience from clinical trials a definition has been developed that should be applicable to all agents that interfere with hemostasis. The definition and the text that follows have been reviewed and approved by relevant co-chairs of the subcommittee and by the Executive Committee of the SSC. The intention is to seek approval of this definition from the regulatory authorities to enhance its incorporation into future clinical trial protocols.

  14. AMPA workshop on challenges faced by investigators conducting Alzheimer's disease clinical trials.

    Science.gov (United States)

    Vellas, Bruno; Pesce, Alain; Robert, Philippe H; Aisen, Paul S; Ancoli-Israel, Sonia; Andrieu, Sandrine; Cedarbaum, Jesse; Dubois, Bruno; Siemers, Eric; Spire, Jean-Paul; Weiner, Michael W; May, Thomas S

    2011-07-01

    The recruitment and retention of patients are among the greatest challenges currently being faced by researchers who conduct Alzheimer's disease (AD) clinical trials. To discuss these challenges and other major issues associated with clinical research in AD, an international workshop was organized by the Association Monégasque pour la recherche sur la Maladie d'Alzheimer at Monte Carlo, Monaco, in February 2010, with the participation of leading research experts in the field of Alzheimer's. Key topics discussed were as follows: (1) the selection, recruitment, and retention of clinical trial subjects; (2) international co-operation among researchers; and (3) patient rights and informed consent for participants in clinical trials. This article highlights some of the challenges faced by investigators when conducting clinical trials in AD, and it also offers some recommendations aimed at overcoming these challenges.

  15. Quality of life of people living with HIV, preliminary results from IANUA (Investigation on Antiretroviral Therapy study

    Directory of Open Access Journals (Sweden)

    Alberto Venturini

    2014-11-01

    Full Text Available Introduction: The introduction of combined antiretroviral treatment (cART has reduced HIV-associated morbidity and mortality, and changed the patients’ perspective of life. As a result, Health Related Quality of Life (HRQOL has become a crucial clinical issue. Objective: Assessment of HRQOL in a sample of Italian patients from IANUA study. Investigate correlation between CD4 cell counts, viral load and changes in HRQOL. Materials and Methods: EQ-5D-3L self-reported questionnaire has been used in the evaluation of HRQOL. It assesses five dimensions: “mobility,” “self care,” “usual activities,” “pain/discomfort” and “anxiety/depression.” Each dimension has three levels: no problems, some problems and extreme problems. In addition, it includes a Visual Analogue Scale (VAS where one's own health “today” is rated from 0 “worst imaginable health” to 100 “best imaginable health.” The respondents provide information on marital status, education, employment/unemployment, other treatments used in addition to HAART (1,2,3,4,5 or more and number of hospitalizations due to HIV/AIDS. Results: 684 patients completed the questionnaire: 231 females and 453 males. The mean age of the sample was 51 years (range 21–78. The mean VAS score was 69.9. 558 patients (81.5% reported no problems in mobility. 642 patients (93.5% had no problems in self care. 423 patients (61.8% had no pain/discomfort while 219 had some problems. 326 patients (46.1% had some problems in anxiety/depression. Conclusions: The analysis of self-reported questionnaires indicates that HRQOL in our sample group is not deeply affected by HIV/AIDS. The dimensions that are affected in the least are “mobility” and “self care” while the major problem is “anxiety/depression” with half of the sample reporting moderate or high level.

  16. Ultrasonic synthetic technique to manufacture a pHEMA nanopolymeric-based vaccine against the H6N2 avian influenza virus: a preliminary investigation

    Directory of Open Access Journals (Sweden)

    Poinern GEJ

    2011-09-01

    Full Text Available Gérrard Eddy Jai Poinern1, Xuan Thi Le1, Songhua Shan2, Trevor Ellis3, Stan Fenwick3, John Edwards3, Derek Fawcett11Murdoch Applied Nanotechnology Research Group, Murdoch University, Murdoch, WA, Australia; 2Australian Animal Health Laboratories, CSIRO, VIC, Australia; 3Veterinary School, School of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, WA, AustraliaAbstract: This preliminary study investigated the use of poly (2-hydroxyethyl methacrylate (pHEMA nanoparticles for the delivery of the deoxyribonucleic acid (DNA vaccine pCAG-HAk, which expresses the full length hemagglutinin (HA gene of the avian influenza A/Eurasian coot/Western Australian/2727/1979 (H6N2 virus with a Kozak sequence which is in the form of a pCAGGS vector. The loaded and unloaded nanoparticles were characterized using field-emission scanning electron microscopy. Further characterizations of the nanoparticles were made using atomic force microscopy and dynamic light scattering, which was used to investigate particle size distributions. This preliminary study suggests that using 100 µg of pHEMA nanoparticles as a nanocarrier/adjuvant produced a reduction in virus shedding and improved the immune response to the DNA vaccine pCAG-HAk.Keywords: nanoparticles, ultrasound, deoxyribonucleic acid, plasmid, bird flu, pandemic

  17. Investigating the Attitude of Graduate Psychiatrists towards Objective Structured Clinical Examination (OSCE and Conventional Clinical Interview Examination.

    Directory of Open Access Journals (Sweden)

    Ali Nazeri Astaneh

    2014-06-01

    Full Text Available In the present study, we investigated the attitude of psychiatrists who graduated in 2002-2009 towards Objective Structured Clinical Examination (OSCE and conventional clinical interview examination (Individual Patient Assessment.We studied 134 psychiatrists graduated; half of whom were examined with conventional clinical interview and the others with OSCE. A questionnaire was prepared by a specialist workgroup to assess the participants' attitude towards the exams. The questionnaire was initially examined in a pilot study. The findings of the questionnaire were used to assess the graduates' attitude towards each examination, as well as to compare the examinations.The OSCE group indicated a significantly more positive attitude compared to the conventional group (p = 0.03. Furthermore, the OSCE group believed the role of theoretical knowledge (p = 0.01 and pre-test practice (p = 0.03 to be significantly greater for success compared to the other group. The structure of OSCE was reported to be superior to conventional examination in terms of fairness and homogeneity (p = 0.004. First participation in exam (p = 0.04 and ultimate success in the exam (p = 0.009 were predictors of graduates' attitude.Based on examinees 'attitudes, OSCE may be a more appropriate choice for graduation examinations of psychiatry compared to the conventional clinical interview examination.

  18. Inability of positive phase II clinical trials of investigational treatments to subsequently predict positive phase III clinical trials in glioblastoma.

    Science.gov (United States)

    Mandel, Jacob J; Yust-Katz, Shlomit; Patel, Akash J; Cachia, David; Liu, Diane; Park, Minjeong; Yuan, Ying; A Kent, Thomas; de Groot, John F

    2017-07-31

    Glioblastoma is the most common primary malignant brain tumor in adults, but effective therapies are lacking. With the scarcity of positive phase III trials, which are increasing in cost, we examined the ability of positive phase II trials to predict statistically significant improvement in clinical outcomes of phase III trials. A PubMed search was conducted to identify phase III clinical trials performed in the past 25 years for patients with newly diagnosed or recurrent glioblastoma. Trials were excluded if they did not examine an investigational chemotherapy or agent, if they were stopped early owing to toxicity, if they lacked prior phase II studies, or if a prior phase II study was negative. Seven phase III clinical trials in newly diagnosed glioblastoma and 4 phase III clinical trials in recurrent glioblastoma met the inclusion criteria. Only 1 (9%) phase III study documented an improvement in overall survival and changed the standard of care. The high failure rate of phase III trials demonstrates the urgent need to increase the reliability of phase II trials of treatments for glioblastoma. Strategies such as the use of adaptive trial designs, Bayesian statistics, biomarkers, volumetric imaging, and mathematical modeling warrant testing. Additionally, it is critical to increase our expectations of phase II trials so that positive findings increase the probability that a phase III trial will be successful.

  19. A new biomarker of hedonic eating? A preliminary investigation of cortisol and nausea responses to acute opioid blockade.

    Science.gov (United States)

    Daubenmier, Jennifer; Lustig, Robert H; Hecht, Frederick M; Kristeller, Jean; Woolley, Josh; Adam, Tanja; Dallman, Mary; Epel, Elissa

    2014-03-01

    Overweight and obese individuals differ in their degree of hedonic eating. This may reflect adaptations in reward-related neural circuits, regulated in part by opioidergic activity. We examined an indirect, functional measure of central opioidergic activity by assessing cortisol and nausea responses to acute opioid blockade using the opioid antagonist naltrexone in overweight/obese women (mean BMI=31.1±4.8) prior to the start of a mindfulness-based intervention to reduce stress eating. In addition, we assessed indices of hedonic-related eating, including eating behaviors (binge eating, emotional eating, external eating, restraint) and intake of sweets/desserts and carbohydrates (Block Food Frequency); interoceptive awareness (which is associated with dysregulated eating behavior); and level of adiposity at baseline. Naltrexone-induced increases in cortisol were associated with greater emotional and restrained eating and lower interoceptive awareness. Naltrexone-induced nausea was associated with binge eating and higher adiposity. Furthermore, in a small exploratory analysis, naltrexone-induced nausea predicted treatment response to the mindfulness intervention, as participants with more severe nausea at baseline maintained weight whereas those with little or no nausea responses tended to gain weight. These preliminary data suggest that naltrexone-induced cortisol release and nausea may help identify individuals who have greater underlying food reward dependence, which leads to an excessive drive to eat. Future research is needed to confirm this finding and to test if these markers of opioidergic tone might help predict success in certain types of weight management programs.

  20. Molecular characterization of dominant bacterial population in “Vastedda della Valle del Belice” cheese: preliminary investigation

    Directory of Open Access Journals (Sweden)

    M. Todaro

    2010-04-01

    Full Text Available The sensory characteristics of raw-milk cheeses are linked to the cheese-making process, to the environmental factors as animal feeding and to the biochemical and microbiological composition of the milk. In this report we temped to characterize the microflora in the typical Sicilian historical cheese as Vastedda della valle del Belice. Each cheese was previous subjected to microbial isolation on specific media (M17 and MRS. The colony obtained on the solid medium were subject to biochemical tests and DNA extraction. The microbial diversity occurring in the strains was evaluated by PCR, RFLP and sequencing targeted on 16S ribosomal DNA. A number of closest relatives species of lactic and contaminating bacteria were identified in a total of 18 cheeses. The more represented genus were: Enterococcus, Streptococcus, Lactobacillus, Lactococcus and Pediococcus. Moreover it was found only one strain Lactococcus lactis for producing bacteriocines. The different bacteria species probably could play a key role in the maturation of the cheese. The preliminary obtained data show the optimized method is usefully to detect and characterize the bacteria having implications in the fermentation process as well as preservation of traditional products.

  1. Preoperative characteristics of auditory brainstem response in acoustic neuroma with useful hearing: importance as a preliminary investigation for intraoperative monitoring.

    Science.gov (United States)

    Aihara, Noritaka; Murakami, Shingo; Takahashi, Mariko; Yamada, Kazuo

    2014-01-01

    We classified the results of preoperative auditory brainstem response (ABR) in 121 patients with useful hearing and considered the utility of preoperative ABR as a preliminary assessment for intraoperative monitoring. Wave V was confirmed in 113 patients and was not confirmed in 8 patients. Intraoperative ABR could not detect wave V in these 8 patients. The 8 patients without wave V were classified into two groups (flat and wave I only), and the reason why wave V could not be detected may have differed between the groups. Because high-frequency hearing was impaired in flat patients, an alternative to click stimulation may be more effective. Monitoring cochlear nerve action potential (CNAP) may be useful because CNAP could be detected in 4 of 5 wave I only patients. Useful hearing was preserved after surgery in 1 patient in the flat group and 2 patients in wave I only group. Among patients with wave V, the mean interaural latency difference of wave V was 0.88 ms in Class A (n = 57) and 1.26 ms in Class B (n = 56). Because the latency of wave V is already prolonged before surgery, to estimate delay in wave V latency during surgery probably underestimates cochlear nerve damage. Recording intraoperative ABR is indispensable to avoid cochlear nerve damage and to provide information for surgical decisions. Confirming the condition of ABR before surgery helps to solve certain problems, such as choosing to monitor the interaural latency difference of wave V, CNAP, or alternative sound-evoked ABR.

  2. A preliminary investigation of the environmental Control and Life Support Subsystems (EC/LSS) for animal and plant experiment payloads

    Science.gov (United States)

    Wells, H. B.

    1972-01-01

    A preliminary study of the environmental control and life support subsystems (EC/LSS) necessary for an earth orbital spacecraft to conduct biological experiments is presented. The primary spacecraft models available for conducting these biological experiments are the space shuttle and modular space station. The experiments would be housed in a separate module that would be contained in either the shuttle payload bay or attached to the modular space station. This module would be manned only for experiment-related tasks, and would contain a separate EC/LSS for the crew and animals. Metabolic data were tabulated on various animals that are considered useful for a typical experiment program. The minimum payload for the 30-day space shuttle module was found to require about the equivalent of a one-man EC/LSS; however, the selected two-man shuttle assemblies will give a growth and contingency factor of about 50 percent. The maximum payloads for the space station mission will require at least a seven-man EC/LSS for the laboratory colony and a nine-man EC/LSS for the centrifuge colony. There is practically no room for growth or contingencies in these areas.

  3. Positive Affect Stimulation and Sustainment (PASS) Module for Depressed Mood: A preliminary investigation of treatment-related effects.

    Science.gov (United States)

    McMakin, Dana L; Siegle, Greg J; Shirk, Stephen R

    2011-06-01

    Positive affective functioning (PAF) is critical to the development, course and treatment of depressive symptoms. Targeting key features of PAF during treatment may provide a new angle through which to improve affective functioning and reduce symptoms. The current study was a treatment development trial for the Positive Affect Stimulation and Sustainment (PASS) Module. PASS is conceptualized as a means of capitalizing on positive events (e.g. planned through behavioral activation) by enhancing and sustaining positive affective states through savoring, and establishing positive attributions and expectancies. Participants were 27 female college students with dysphoric symptoms. There was a moderate effect of PASS on depressive symptoms. There was also a significant within session increase in positive affect from pre to post session among the PASS group, relative to active control; and a significant decrease in positive affect from pre (baseline) to post (follow-up) treatment among the control group, relative to PASS. Results provide preliminary evidence for the efficacy of the treatment module among young adults with depressed mood, and lay the foundation for future research.

  4. Preliminary investigation into the pressing process of sweet pearl millet and sweet sorghum biomass for ethanol production

    Energy Technology Data Exchange (ETDEWEB)

    Crepeau, M.; Khelifi, M.; Vanasse, A. [Laval Univ., Quebec City, PQ (Canada). Dept. of Soil Science and Agri-Food Engineering

    2010-07-01

    Corn is the main source for biofuel production in North America. However, both sweet pearl millet and sweet sorghum crops represent an interesting alternative to corn for ethanol production because of their high biomass yield under a wide range of environmental conditions and high concentration of readily fermentable sugars. Coproducts such as pressing residues can be also be utilized so that nothing is lost in the process. However, in order to improve the extraction of juice for ethanol production, the pressing process of this biomass must be optimized. Preliminary experiments were therefore conducted to optimize the juice extraction from sweet pearl millet and sweet sorghum using 2 different presses, notably a screw press and a manually operated hydraulic press. Both types of biomass were either chopped finely or coarsely and were exposed to various pressures with the hydraulic press. The volume of juice extracted from both crops increased linearly with increasing pressure. Sweet sorghum appeared to be a better feedstock for ethanol production because it produced about 0.03 to 0.06 litre of juice per kg of biomass more than sweet pearl millet. Juice extraction was more effective with the screw press, but only a small difference was noted between the 2 chopping modes.

  5. Environmental pollen trapped by tobacco leaf as indicators of the provenance of counterfeit cigarette products: a preliminary investigation and test of concept.

    Science.gov (United States)

    Donaldson, Margaret P; Stephens, William E

    2010-05-01

    The global trade in counterfeit tobacco products is increasingly taking market share from legal brands in many parts of the developed world, with attendant adverse economic, health, criminal, and other societal impacts. Knowing the geographical source is central to developing new strategies for curbing this illicit trade, and here, the potential of environmental pollen extracted from manufactured cigarettes is examined. Two samples representing U.S. and Chinese brands were investigated for their pollen content. Results indicate that tobacco leaf very efficiently captures environmental pollen (about 1800 and 12,600 grains per cigarette, respectively) with no detectable self-contamination by the tobacco plant. In both cases, the flora is typical of open space environments, but pollen type counts indicate very different distributions of species. This preliminary investigation indicates that palynology has the potential to constrain geographical source(s) of tobacco, particularly if regionally localized species can be recognized among the pollen.

  6. Clinical FDG PET CT in the Investigation of Suspected Inflammatory and Infective Conditions

    DEFF Research Database (Denmark)

    Lorenz, Eleanor; Wig, Surabhi; Prakash, Vineet

    PURPOSE          F18 FDG PET CT is an established molecular imaging technique most commonly used in the diagnosis and staging of oncological conditions. A rapidly growing clinical application of PET CT is in the investigation of inflammatory and infectious diseases. A review of PET CT scans perfo...

  7. An academic writing needs assessment of English-as-a-second-language clinical investigators.

    Science.gov (United States)

    Wang, Min-Fen; Bakken, Lori L

    2004-01-01

    Academic writing for publication is competitive and demanding for researchers. For the novice English-as-a-second-language (ESL) researcher, the pressure to publish compounds the difficulties of mastering the English language. Very few studies have used ESL graduate and post-graduate students as academic writing research subjects. The purpose of this project was to assess the learning needs of ESL clinical investigators regarding academic writing for English scholarly publication. A qualitative evaluation approach was used to examine the gap between the current and desired proficiency level for the academic writing of ESL clinical investigators. We considered the perspectives of seven ESL clinical investigators plus three mentors and three writing instructors. Semi-structured questions were asked. Field notes were organized using a field-work recording system. They were analyzed using the constant comparative method. ESL clinical investigators do not accurately perceive their writing deficiencies. They have little knowledge of criteria for academic writing and they are influenced by their prior English learning experiences in their home culture, which engender passive attitudes toward seeking appropriate writing resources. Adequate time is especially needed to develop successful writing skills. Four basic steps are recommended to guide program planners in developing ESL writing activities for professional learning: (1) recognize discrepancies, (2) establish clear standards and performance criteria for scholarly writing, (3) develop individual plans, and (4) organize long-term writing assistance.

  8. Using Hermeneutic Phenomenology to Investigate How Experienced Practitioners Learn to Communicate Clinical Reasoning

    Science.gov (United States)

    Ajjawi, Rola; Higgs, Joy

    2007-01-01

    This paper is primarily targeted at doctoral students and other researchers considering using hermeneutic phenomenology as a research strategy. We present interpretive paradigm research designed to investigate how experienced practitioners learn to communicate their clinical reasoning in professional practice. Twelve experienced physiotherapy…

  9. Naa Technique for Clinical Investigation of Mice Immunized with BOTHROP Venom

    Science.gov (United States)

    Zamboni, C. B.; Aguiar, R. O.; Kovacs, L.; Suzuki, M.; Sant'Anna, O. A.

    2009-06-01

    In the present study Neutron Activation Analysis (NAA) technique was used to determine sodium concentration in whole blood of mice immunized with Bothrops venom. With this value it was possible to perform clinical investigation in this animal model using whole blood.

  10. Investigation and analysis of clinical trial research nurse to perform standard operating procedures

    Institute of Scientific and Technical Information of China (English)

    Yan Lin; Yan-Yun Wu; Mei-Hua Wu; Xiu-Yu Yang; Ming Zhou

    2016-01-01

    Objective: The aim of this study was to investigate the situations and factors that cause nurses not to follow standard operating procedures (SOPs) during the clinical trial process. Methods: Five cases involving patients enrolled in a clinical trial were divided into two groups, pre-SOP training and post-SOP training, to compare and observe the process problems and whether nurses fol-lowed SOPs in clinical trials. The causes of problems were analyzed and corrective measures were proposed. Results: Our results indicate significant improvement in compliance with SOPs after training. There were three occurrences of irregular behavior after training compared with 21 occurrences of irregular behavior before training. Conclusions: The quality of clinical trials can be improved if nurses strictly follow SOPs.

  11. A Preliminary Teleseismic Investigation of the Crust and Mantle Lithosphere Obtained from BISN in the Western Canadian Arctic

    Science.gov (United States)

    Schaeffer, A. J.; Snyder, D. B.; Cairns, S.; Elliot, B.; Audet, P.; Esteve, C.; Murray-Bergquist, L.; Falck, H.

    2016-12-01

    The tectonic evolution of the Beaufort Sea continental margin has contributed to the maturation of these rocks into a major petroleum reservoir. Recent shallow offshore seismic reflection data suggest that Banks Island represents thin crust along a rifted margin established during the opening of the Arctic Ocean. In this case, rifting of the margin caused Banks Island to subside and accumulate sediments rich in petroleum source material. The cooling history and further subsidence of these sediments is important for understanding the thermal maturation of petroleum products. Recently published surface-wave velocity models of North America indicate seismic velocities at 100-150 km depths similar to those beneath Canada's diamond mines in the central Slave craton north of Yellowknife. These results imply that Banks Island is part of the Canadian Shield and that any kimberlites found thereon might contain diamonds. However, the fast velocities are inconsistent with this being a tectonically disrupted and thinned lithosphere along the Arctic margin of the Canada Basin. The problem is therefore to reconcile mantle structure typical of the Canadian Shield with crust typical of a rifted passive margin. Possibly related seismicity beneath the Mackenize River Delta and offshore in the Beaufort Sea has been observed for decades but its origin remains unknown, although has been suggested as due to incipient subduction of oceanic lithosphere beneath the North American craton. Resolving these questions requires high-resolution 3-D seismic models obtained from an array of broadband seismograph stations. Here we present preliminary results on the structure of the crust and uppermost mantle underlying the western Canadian Arctic. These results are generated using new data from the Banks Island Seismograph Network (BISN), three stations installed over the summer of 2014 and 2015; augmented with several USArray Transportable Array stations and older POLARIS and CNSN stations on

  12. The relationship between senior management team culture and clinical governance: Empirical investigation and managerial implications.

    Science.gov (United States)

    Prenestini, Anna; Calciolari, Stefano; Lega, Federico; Grilli, Roberto

    2015-01-01

    Health care organizations are pressured to improve the cost-effectiveness of service delivery. Clinical governance is an important trigger to improve care quality and safety and rank high in the reform agenda of health systems. The senior management team culture plays a major role in establishing clinical governance practices, because it strongly influences the values, attitudes, and behaviors of the members of an organization. The aim of this study was to investigate the relationship between senior management team culture and clinical governance in the public health care organizations of three Italian regions. The assessment of senior management culture was conducted using the Competing Values Framework and a corresponding instrument adapted for the Italian context. Clinical governance was assessed using an ad hoc instrument focused on the senior management team's perception and attitude toward clinical governance. The survey achieved a 54% response rate. The results of four different models demonstrate that organizations characterized by different dominant cultures are associated with significant differences in attitudes toward clinical governance. In particular, on average, dominant cultures with a prevailing external focus are associated with a more positive attitude toward clinical governance. The selection and appointments of top managers should consider the style of leadership that is most apt to facilitate the growth of rational and developmental cultures. Furthermore, the training of top managers and leading doctors should reinforce leadership aptitude and approaches that are consistent with the desired organizational cultures.

  13. Clinical research: business opportunities for pharmacy-based investigational drug services.

    Science.gov (United States)

    Marnocha, R M

    1999-02-01

    The application by an academic health center of business principles to the conduct of clinical research is described. Re-engineering of the infrastructure for clinical research at the University of Wisconsin and University of Wisconsin Hospital and Clinics began in 1990 with the creation of the Center for Clinical Trials (CCT) and the restructuring of the investigational drug services (IDS). Strategies to further improve the institution's clinical research activities have been continually assessed and most recently have centered on the adaptation of a business philosophy within the institution's multidisciplinary research infrastructure. Toward that end, the CCT and IDS have introduced basic business principles into operational activities. Four basic business concepts have been implemented: viewing the research protocol as a commodity, seeking payment for services rendered, tracking investments, and assessing performance. It is proposed that incorporation of these basic business concepts is not only compatible with the infrastructure for clinical research but beneficial to that infrastructure. The adaptation of a business mindset is likely to enable an academic health center to reach its clinical research goals.

  14. Investigation Clinical Competence and Its Relationship with Professional Ethics and Spiritual Health in Nurses

    Directory of Open Access Journals (Sweden)

    Elahe Ramezanzade Tabriz

    2017-03-01

    Full Text Available Abstract Background and Objectives: Study of clinical competence in nursing helps determine the quality of health care delivered to patients. Given the priority of observance of principles over caretaking and necessity of spirituality existence at the core of health care provision, this study was conducted to investigate clinical competence and its relationship with professional ethics and spiritual health in nurses. Methods: In this cross-sectional, descriptive, and correlational study, 281 nurses were enrolled by consensus sampling. Sampling was conducted from February, 2016 till June, 2016. The data were gathered by a demographics questionnaire, a self-assessment scale of clinical competence, a nursing ethics questionnaire, and a spiritual health questionnaire, and analyzed by descriptive statistics and t-test, Pearson's correlation coefficient, ANOVA, and linear regression analysis in SPSS 21. Results: The total scores for self-assessment scale of nurses' clinical competence, professional ethics, and spiritual health were moderate. In the light of the results of Spearman's correlation coefficient, there was a significant and positive correlation between clinical competence and spiritual health. Moreover, a significant positive correlation was observed between professional ethics and spiritual health but there was no correlation between professional ethics and clinical competence. Conclusion: Managers' and personnel's Knowledge about the level of nurses clinical competence, professional ethics, and spiritual health in teaching health care centers provides valuable information to develop in-service and efficacious education programs and ultimately to improve the quality of nursing services.

  15. Preliminary Investigation of the Relationship Between Bovine Congenital Lathyrism Induced by Aminoacetonitrile and the Lupine Induced Crooked Calf Disease

    Science.gov (United States)

    Keeler, R. F.; Binns, W.; James, L. F.; Shupe, J. L.

    1969-01-01

    Maternal feeding of the lathyrogen aminoacetonitrile, the range plant Lupinus caudatus, and an extract of this plant — expected to contain lathyrogens if present in the plant — all produced clinically similar congenital defects in calves. The defects included excessive flexure, malpositioning, malalignment and rotation of the front limbs. The results suggest a possible relationship between lathyrism and lupine-induced crooked calf disease. ImagesFig. 1.Fig. 2.Fig. 3.Fig. 4.Fig. 5.Fig. 6. PMID:4238569

  16. Preliminary investigation of /sup 68/Ga-pyrophosphate as a potential scanning agent. [Toxicity testing in mice and rabbits

    Energy Technology Data Exchange (ETDEWEB)

    Klopper, J.F.; Srivastava, S.; Meinken, G.; Atkins, H.L.; Richards, P.

    1976-01-01

    Studies in mice and rabbits indicate that it would be possible to obtain the ideal low levels of blood radioactivity required for heart imaging with /sup 68/Ga-PYP only with the addition of relatively high (5-10 mg/kg) levels of carrier gallium. Since the toxicity of such levels of gallium could be outside of the safety margin, the usefulness of the method for clinical studies may be limited.

  17. [Standard Cancer Therapy Are Established by the Investigator-Initiated Post-Marketing Clinical Trials, Not by the Indication-Directed Clinical Trials].

    Science.gov (United States)

    Shimada, Yasuhiro

    2016-04-01

    The financial supports for investigator-initiated post-marketing clinical trial in clinical oncology are reduced after scandals related to the other fields of clinical trials in Japan. These clinical trials are the essential final steps of clinical development in newer cancer therapy, which should be conducted in the investigator-initiated clinical trial groups with well-organized infrastructure and continuous financial supports. The present problems are discussed and summarized. Future perspectives with the national viewpoints needed to be included the idea of "health technology assessment".

  18. Preliminary efficacy investigations of oral fipronil against Anopheles arabiensis when administered to Zebu cattle (Bos indicus) under field conditions.

    Science.gov (United States)

    Poché, Richard M; Githaka, Naftaly; van Gool, Frans; Kading, Rebekah C; Hartman, Daniel; Polyakova, Larisa; Abworo, Edward Okoth; Nene, Vishvanath; Lozano-Fuentes, Saul

    2017-12-01

    the treatment plot two was higher: zero females were collected after treatment. The indoor resting density of An. gambiae s.s. was not significantly different between the treatment (T1, T2) and their corresponding control plots (C1, C2). An. funestus s.s. showed an increase in density over time. The results of this preliminary study suggest that treating cattle orally with fipronil, to target exophagic and zoophagic malaria vectors, could be a valuable control strategy to supplement existing vector control interventions which target endophilic anthropophilic species. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  19. The Verbal Clock Test: preliminary validation of a brief, vision- and motor-free measure of executive function in a clinical sample.

    Science.gov (United States)

    Cercy, Steven P

    2012-01-01

    Assessment of executive functions is frequently time-consuming, and although some brief measures exist they are subject to problems associated with limited education, culture of origin, impairments of motor or visual systems, and tolerability. Preliminary validation of a newly developed measure, the Verbal Clock Test (VCT), was conducted in a clinical sample of 294 patients who underwent neuropsychological evaluation. The evidence supports the interpretation of VCT scores as demonstrating construct validity, criterion-related validity, and sound internal consistency. Performance does not vary substantially with gender or mood, and variability associated with age, education, and ethnicity is modest. Confounding effects of motor and visual impairments are eliminated. Initial data suggest the VCT represents a reasonable method of assessing abstract reasoning and concept formation when clinical circumstances limit the use of currently available measures.

  20. Preliminary clinical prediction rule for identifying patients with ankylosing spondylitis who are likely to respond to an exercise program: a pilot study.

    Science.gov (United States)

    Alonso-Blanco, Cristina; Fernández-de-las-Peñas, César; Cleland, Joshua A

    2009-06-01

    The aim of this study was to develop a preliminary clinical prediction rule to identify the potential predictors for identifying patients presenting with ankylosing spondylitis who are likely to respond to a specific exercise program. Consecutive patients with ankylosing spondylitis underwent a standardized examination and then received eight physical therapy sessions during a 2-mo period, which included an exercise program based on the treatment of the shortened muscle chains, following the guideline described by the global posture re-education method. Patients were classified as having experienced a successful outcome at 1 mo after discharge based on a 20% reduction on Bath Ankylosing Spondylitis Functional Index and self-report perceived recovery. Potential predictor variables were entered into a stepwise logistic regression model to determine the most accurate set of variables for identifying treatment success. Data from 35 patients were included, of which 16 (46%) experienced a successful outcome. A clinical prediction rule with three variables (physical role >37, bodily pain >27, and Bath Ankylosing Spondylitis Disease Activity Index >31) was identified. The most accurate predictor of success was if the patient exhibited two of the three variables, and the positive likelihood ratio was 11.2 (95% confidence interval, 1.7-76.0) and the posttest probability of success increased to 91%. The accuracy of prediction declined if either 1/3 (+likelihood ratio = 7.7; 95% confidence interval, 0.52-113.5) or 3/3 (+likelihood ratio = 2.6, 95% confidence interval, 1.6-4.0) variables were present. The present preliminary clinical prediction rule provides the potential to identify patients with ankylosing spondylitis who are likely to experience short-term follow-up success with a specific exercise program. Future studies are necessary to validate the clinical prediction rule.