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Sample records for preinjury performance profile

  1. HOPWA Performance Profiles

    Data.gov (United States)

    Department of Housing and Urban Development — HOPWA Performance Profiles are generated quarterly for all agencies receiving HOPWA formula or competitive grants. Performance Profiles are available at the national...

  2. Assessment of pre-injury health-related quality of life: a systematic review.

    Science.gov (United States)

    Scholten, Annemieke C; Haagsma, Juanita A; Steyerberg, Ewout W; van Beeck, Ed F; Polinder, Suzanne

    2017-03-14

    Insight into the change from pre- to post-injury health-related quality of life (HRQL) of trauma patients is important to derive estimates of the impact of injury on HRQL. Prospectively collected pre-injury HRQL data are, however, often not available due to the difficulty to collect these data before the injury. We performed a systematic review on the current methods used to assess pre-injury health status and to estimate the change from pre- to post-injury HRQL due to an injury. A systematic literature search was conducted in EMBASE, MEDLINE, and other databases. We identified studies that reported on the pre-injury HRQL of trauma patients. Articles were collated by type of injury and HRQL instrument used. Reported pre-injury HRQL scores were compared with general age- and gender-adjusted norms for the EQ-5D, SF-36, and SF-12. We retrieved results from 31 eligible studies, described in 41 publications. All but two studies used retrospective assessment and asked patients to recall their pre-injury HRQL, showing widely varying timings of assessments (soon after injury up to years after injury). These studies commonly applied the SF-36 (n = 13), EQ-5D (n = 9), or SF-12 (n = 3) using questionnaires (n = 14) or face-to-face interviews (n = 11). Two studies reported prospective pre-injury assessment, based on prospective longitudinal cohort studies from a sample of initially non-injured patients, and applied questionnaires using the SF-36 or SF-12. The recalled pre-injury HRQL scores of injury patients consistently exceeded age- and sex-adjusted population norms, except in a limited number of studies on injury types of higher severity (e.g., traumatic brain injury and hip fractures). All studies reported reduced post-injury HRQL compared to pre-injury HRQL. Both prospective studies reported that patients had recovered to their pre-injury levels of physical and mental health, while in all but one retrospective study patients did not regain the

  3. Retrospectively evaluated preinjury personality traits influence postconcussion symptoms.

    Science.gov (United States)

    Yuen, Kit-Man; Tsai, Yi-Hsin; Lin, Wei-Chi; Yang, Chi-Cheng; Huang, Sheng-Jean

    2016-01-01

    Postconcussion symptoms (PCS) are not uncommon following mild traumatic brain injury (mTBI). Personality traits have always been viewed as one of the most important explanations for persistent postconcussion symptoms (PPCS). Unfortunately, studies on the association between preinjury personality traits and the PPCS are still limited. This study thus aimed to examine the relationship between the preinjury personality and PCS in patients with mTBI. A total of 106 participants including 53 healthy participants were recruited. All participants complete the modified Checklist of Postconcussion Symptoms and the Health, Personality, & Habit Scale. Participants were evaluated within 4 weeks and at 4 months, respectively, after injury. The results showed patients reported significantly more PCS than healthy participants did within 4 weeks postinjury. A significant positive association between PCS and retrospectively evaluated preinjury personality was found. Specifically, patients who reported that their preinjury personality was depressive or anxious-related presented more PCS. This study might be the first to directly demonstrate that preinjury personality traits are closely linked to PCS reporting in patients with mTBI. Importantly, PCS reporting might be associated with different personality traits at different periods after injuries, and thus, a careful evaluation for personality characteristics is merited after mTBI.

  4. Reconstrução do ligamento cruzado anterior: impacto do desempenho muscular e funcional no retorno ao mesmo nível de atividade pré-lesão Reconstruction of the anterior cruciate ligament: impact of muscular and functional performances on the return to pre-injury activity level

    Directory of Open Access Journals (Sweden)

    Lygia Paccini Lustosa

    2007-01-01

    Full Text Available INTRODUÇÃO: A reconstrução do LCA objetiva restabelecer a biomecânica e minimizar a instabilidade do joelho. OBJETIVO: comparar performance muscular, funcional e frouxidão ligamentar, entre voluntários que retornaram ao mesmo nível de atividade pré-lesão e aqueles que não retornaram, após a reconstrução ligamentar. MÉTODOS: 25 homens, operados pelo mesmo cirurgião, com o ligamento patelar, via artroscopia e mais de dois anos de pós-operatório. Utilizou-se a Cincinnati Knee Rating System para divisão em: grupo adaptado - 15 indivíduos - retornaram ao mesmo nível pré-lesão e grupo não adaptado - 10 indivíduos - não retornaram ao mesmo nível. Todos realizaram o hop test e a corrida em oito para avaliação do desempenho funcional. A performance muscular foi avaliada pelo dinamômetro isocinético (Biodex System 3 Pro® e a frouxidão ligamentar determinada pelo artrômetro KT-1000 (Medmetric®. Utilizou-se o teste t independente e ANOVA para análise de associação. RESULTADOS: não houve diferença significativa entre os grupos em nenhuma das variáveis testadas e não houve diferença entre os membros - operado e não operado. CONCLUSÃO: O não retorno ao mesmo nível funcional pré-lesão não pode ser explicado pela frouxidão ligamentar residual ou pelas diferenças do desempenho muscular e funcional.INTRODUCTION: ACL reconstruction targets the reestablishment of joint biomechanics and minimization of knee instability. OBJECTIVE: to compare muscular and functional performances, and passive joint laxity between volunteers who, after ligament reconstruction, returned to the same pre-injury activity level and those who did not, METHODS: 25 men who had their ACL ligament arthroscopically reconstructed (patellar ligament by the same surgeon, at least two years previously were included in the study. The Cincinnati Knee Rating System was used in order to divide the volunteers into: Adapted Group - 15 individuals who

  5. CDBG Performance Profiles - PY12

    Data.gov (United States)

    Department of Housing and Urban Development — These profiles significantly increase the amount of information that is available about the performance of CDBG grantees. It is important that our grantees, all our...

  6. Preinjury resilience and mood as predictors of early outcome following mild traumatic brain injury.

    Science.gov (United States)

    McCauley, Stephen R; Wilde, Elisabeth A; Miller, Emmy R; Frisby, Melissa L; Garza, Hector M; Varghese, Reni; Levin, Harvey S; Robertson, Claudia S; McCarthy, James J

    2013-04-15

    There is significant heterogeneity in outcomes following mild traumatic brain injury (mTBI). While several host factors (age, gender, and preinjury psychiatric history) have been investigated, the influence of preinjury psychological resilience and mood status in conjunction with mild TBI remains relatively unexplored. Euthymic mood and high resilience are potentially protective against anxiety and postconcussion symptoms, but their relative contributions are currently unknown. This prospective study obtained preinjury estimates of resilience and mood measures in addition to measures of anxiety (Acute Stress Disorder Scale and PTSD-Checklist-Civilian form) and postconcussion symptom severity (Rivermead Post Concussion Symptoms Questionnaire) resilience or mood status at baseline, but differed significantly on measures of anxiety and postconcussion symptom severity at each subsequent study occasion. Multivariate linear regression analyses were conducted to determine if preinjury resilience and mood were significant contributors to anxiety and postconcussion symptoms during the first month postinjury after accounting for other known host factors (e.g., age at injury, gender, and education). Injury group and preinjury mood status were significant predictors for all three dependent variables at each study occasion (all presilience showed a positive trend only for acute stress severity at baseline, but demonstrated significant prediction of all three dependent measures at one week and one month postinjury. These results suggest that preinjury depressed mood and resilience are significant contributors to the severity of postinjury anxiety and postconcussion symptoms, even after accounting for effects of other specific host factors.

  7. Psychological responses matter in returning to preinjury level of sport after anterior cruciate ligament reconstruction surgery.

    Science.gov (United States)

    Ardern, Clare L; Taylor, Nicholas F; Feller, Julian A; Whitehead, Timothy S; Webster, Kate E

    2013-07-01

    Up to two-thirds of athletes may not return to their preinjury level of sport by 12 months after anterior cruciate ligament (ACL) reconstruction surgery, despite being physically recovered. This has led to questions about what other factors may influence return to sport. To determine whether psychological factors predicted return to preinjury level of sport by 12 months after ACL reconstruction surgery. Case control study; Level of evidence, 3. Recreational and competitive-level athletes seen at a private orthopaedic clinic with an ACL injury were consecutively recruited. The primary outcome was return to the preinjury level of sports participation. The psychological factors evaluated were psychological readiness to return to sport, fear of reinjury, mood, emotions, sport locus of control, and recovery expectations. Participants were followed up preoperatively and at 4 and 12 months postoperatively. In total, 187 athletes participated. At 12 months, 56 athletes (31%) had returned to their preinjury level of sports participation. Significant independent contributions to returning to the preinjury level by 12 months after surgery were made by psychological readiness to return to sport, fear of reinjury, sport locus of control, and the athlete's estimate of the number of months it would take to return to sport, as measured preoperatively (χ(2) 2 = 18.3, P sport at 12 months, suggesting that attention to psychological recovery in addition to physical recovery after ACL injury and reconstruction surgery may be warranted. Clinical screening for maladaptive psychological responses in athletes before and soon after surgery may help clinicians identify athletes at risk of not returning to their preinjury level of sport by 12 months.

  8. Performance profiles of major energy producers 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-02-01

    Performance Profiles of Major Energy Producers 1994 is the eighteenth annual report of the Energy Information Administration`s (EIA) Financial Reporting System (FRS). The report examines financial and operating developments in energy markets, with particular reference to the 24 major U.S. energy companies required to report annually on Form EIA-28. Financial information is reported by major lines of business, including oil and gas production, petroleum refining and marketing, other energy operations, and nonenergy businesses. Financial and operating results are presented in the context of energy market developments with a view toward identifying changing corporate strategies and measuring the performance of ongoing operations both in the United States and abroad.

  9. Performance profiles of major energy producers 1989

    Energy Technology Data Exchange (ETDEWEB)

    1991-01-23

    Performance Profiles of Major Energy Producers 1989 is the thirteenth annual report of the Energy Information Administration's (EIA) Financial Reporting System (FRS). The report examines financial and operating developments, with particular reference to the 23 major energy companies (the FRS companies'') required to report annually on Form EIA-28. Financial information is reported by major lines of business including oil and gas production, petroleum refining and marketing, and other energy operations. Domestic and international operations are examined separately in this report. It also traces key developments affecting the financial performance of major energy companies in 1989, as well as review of important trends.

  10. Performance profiles of major energy producers 1989

    Energy Technology Data Exchange (ETDEWEB)

    1991-01-23

    Performance Profiles of Major Energy Producers 1989 is the thirteenth annual report of the Energy Information Administration's (EIA) Financial Reporting System (FRS). The report examines financial and operating developments, with particular reference to the 23 major energy companies (the FRS companies'') required to report annually on Form EIA-28. Financial information is reported by major lines of business including oil and gas production, petroleum refining and marketing, and other energy operations. Domestic and international operations are examined separately in this report. It also traces key developments affecting the financial performance of major energy companies in 1989, as well as review of important trends.

  11. Pre-injury polypharmacy as a predictor of outcomes in trauma patients

    Science.gov (United States)

    Evans, David C; Gerlach, Anthony T; Christy, Jonathan M; Jarvis, Amy M; Lindsey, David E; Whitmill, Melissa L; Eiferman, Daniel; Murphy, Claire V; Cook, Charles H; Beery, Paul R; Steinberg, Steven M; Stawicki, Stanislaw PA

    2011-01-01

    Background: One of the hallmarks of modern medicine is the improving management of chronic health conditions. Long-term control of chronic disease entails increasing utilization of multiple medications and resultant polypharmacy. The goal of this study is to improve our understanding of the impact of polypharmacy on outcomes in trauma patients 45 years and older. Materials and Methods: Patients of age ≥45 years were identified from a Level I trauma center institutional registry. Detailed review of patient records included the following variables: Home medications, comorbid conditions, injury severity score (ISS), Glasgow coma scale (GCS), morbidity, mortality, hospital length of stay (LOS), intensive care unit (ICU) LOS, functional outcome measures (FOM), and discharge destination. Polypharmacy was defined by the number of medications: 0–4 (minor), 5–9 (major), or ≥10 (severe). Age- and ISS-adjusted analysis of variance and multivariate analyses were performed for these groups. Comorbidity–polypharmacy score (CPS) was defined as the number of pre-admission medications plus comorbidities. Statistical significance was set at alpha = 0.05. Results: A total of 323 patients were examined (mean age 62.3 years, 56.1% males, median ISS 9). Study patients were using an average of 4.74 pre-injury medications, with the number of medications per patient increasing from 3.39 for the 45–54 years age group to 5.68 for the 75+ year age group. Age- and ISS-adjusted mortality was similar in the three polypharmacy groups. In multivariate analysis only age and ISS were independently predictive of mortality. Increasing polypharmacy was associated with more comorbidities, lower arrival GCS, more complications, and lower FOM scores for self-feeding and expression-communication. In addition, hospital and ICU LOS were longer for patients with severe polypharmacy. Multivariate analysis shows age, female gender, total number of injuries, number of complications, and CPS are

  12. Performance profiles of major energy producers 1993

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-01-01

    Performance Profiles of Major Energy Producers 1993 is the seventeenth annual report of the Energy Information Administration`s (EIA) Financial Reporting System (FRS). The report examines financial and operating developments in energy markets, with particular reference to the 25 major US energy companies required to report annually on Form EIA-28. Financial information is reported by major liens of business, including oil and gas production, petroleum refining and marketing, other energy operations, and nonenergy businesses. Financial and operating results are presented in the context of energy market developments with a view toward identifying changing corporate strategies and measuring the performance of ongoing operations both in the US and abroad. This year`s report analyzes financial and operating developments for 1993 (Part 1: Developments in 1993) and also reviews key developments during the 20 years following the Arab Oil Embargo of 1973--1974 (Part 2: Major Energy Company Strategies Since the Arab Oil Embargo). 49 figs., 104 tabs.

  13. Performance profiles of major energy producers 1992

    Energy Technology Data Exchange (ETDEWEB)

    1994-01-13

    Performance Profiles of Major Energy Producers 1992 is the sixteenth annual report of the Energy Information Administration`s (EIA) Financial Reporting System (FRS). The report examines financial and operating developments, with particular reference to the 25 major energy companies (the FRS companies) required to report annually on Form EIA-28. Financial information is reported by major lines of business, including oil and gas production, petroleum refining and marketing, and other energy operations. Domestic and international operations are examined separately in this report. The data are presented in the context of key energy market developments with a view toward identifying changing strategies of corporate development and measuring the apparent success of current ongoing operations.

  14. Performance profiles of major energy producers, 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-01-01

    The energy industry generally and petroleum and natural gas operations in particular are frequently reacting to a variety of unsettling forces. Falling oil prices, economic upswings, currency devaluations, increasingly rigorous environmental quality standards, deregulation of electricity markets, and continued advances in exploration and production technology were among the challenges and opportunities to the industry in 1997. To analyze the extent to which these and other developments have affected energy industry financial and operating performance, strategies, and industry structure, the Energy Information Administration (EIA) maintains the Financial Reporting Systems (FRS). Through Form EIA-28, major US energy companies annually report to the FRS. Financial and operating information is reported by major lines of business, including oil and gas production (upstream), petroleum refining and marketing (downstream), other energy operations, and nonenergy business. Performance Profiles of Major Producers 1997 examines the interplays of energy markets, companies` strategies, and government policies (in 1997 and in historical context) that gave rise to the results given here. The report also analyzes other key aspects of energy company financial performance as seen through the multifaceted lens provided by the FRS data and complementary data for industry overall. 41 figs., 77 tabs.

  15. Pre-injury administration of morphine prevents development of neuropathic hyperalgesia through activation of descending monoaminergic mechanisms in the spinal cord in mice

    Directory of Open Access Journals (Sweden)

    Rashid Md Harunor

    2005-06-01

    Full Text Available Abstract The present study examined whether pre-injury administration of morphine can prevent partial sciatic nerve injury-induced neuropathic pain in mice. We observed that pre-injury administration of subcutaneous (s.c. and intracerebroventricular (i.c.v. morphine dose-dependently prevented the development of both thermal and mechanical hyperalgesia at 7 days following nerve injury in mice. The pre-injury morphine (s.c.-induced analgesia was significantly blocked by pretreatment with naloxone injected s.c. or i.c.v., but not i.t., suggesting that systemic morphine produced the pre-emptying effects mainly by acting at the supra-spinal sites. Since it is believed that activation of descending monoaminergic mechanisms in spinal cord largely contributes to the supra-spinal analgesic effects of morphine, we investigated the involvement of serotonergic and noradrenergic mechanisms in spinal cord in the pre-injury morphine-induced analgesic effects. We found that pre-injury s.c. morphine-induced analgesic effect was significantly blocked by i.t. pretreatment with serotonergic antagonist, methysergide and noradrenergic antagonist, phentolamine. In addition, pre-injury i.t. injection of serotonin uptake inhibitor, fluoxetine and α2-adrenergic agonist, clonidine significantly prevented the neuropathic hyperalgesia. We next examined whether pre-injury morphine prevented the expression of neuronal hyperactivity markers such as c-Fos and protein kinase C γ (PKCγ in the spinal dorsal horn. We found that pre-injury administration of s.c. morphine prevented increased expressions of both c-Fos and PKCγ observed following nerve injury. Similar results were obtained with i.t. fluoxetine and clonidine. Altogether these results suggest that pre-injury administration of morphine might prevent the development of neuropathic pain through activation of descending monoaminergic pain inhibitory pathways.

  16. Using urbanization profiles to assess screening performance

    NARCIS (Netherlands)

    Boon, ME; Kok, LP

    2004-01-01

    The large Dutch data sets acquired as a result of population-based cervical smear screening programs can be further exploited to obtain an urbanization-weighted score to gain insight into the quality of the performance of the individual cytology laboratories. Based on the first four digits of the po

  17. Two Profiles of the Dutch High Performing Employee

    Science.gov (United States)

    de Waal, A. A.; Oudshoorn, Michella

    2015-01-01

    Purpose: The purpose of this study is to explore the profile of an ideal employee, to be more precise the behavioral characteristics of the Dutch high-performing employee (HPE). Organizational performance depends for a large part on the commitment of employees. Employees provide their knowledge, skills, experiences and creativity to the…

  18. Family and academic performance: identifying high school student profiles

    Directory of Open Access Journals (Sweden)

    Alicia Aleli Chaparro Caso López

    2016-01-01

    Full Text Available The objective of this study was to identify profiles of high school students, based on variables related to academic performance, socioeconomic status, cultural capital and family organization. A total of 21,724 high school students, from the five municipalities of the state of Baja California, took part. A K-means cluster analysis was performed to identify the profiles. The analyses identified two clearly-defined clusters: Cluster 1 grouped together students with high academic performance and who achieved higher scores for socioeconomic status, cultural capital and family involvement, whereas Cluster 2 brought together students with low academic achievement, and who also obtained lower scores for socioeconomic status and cultural capital, and had less family involvement. It is concluded that the family variables analyzed form student profiles that can be related to academic achievement.

  19. Implementing a Nurse Manager Profile to Improve Unit Performance.

    Science.gov (United States)

    Krugman, Mary E; Sanders, Carolyn L

    2016-06-01

    Nurse managers face significant pressures in the rapidly changing healthcare environment. Staying current with multiple sources of data, including reports that detail institutional and unit performance outcomes, is particularly challenging. A Nurse Manager Customized Profile was developed at a western academic hospital to provide a 1-page visual of pertinent data to help managers and director supervisors focus coaching to improve unit performance. Use of the Decisional Involvement Scale provided new insights into measuring manager performance.

  20. Psychological factors are important to return to pre-injury sport activity after anterior cruciate ligament reconstruction: expect and motivate to satisfy.

    Science.gov (United States)

    Sonesson, Sofi; Kvist, Joanna; Ardern, Clare; Österberg, Annika; Silbernagel, Karin Grävare

    2017-05-01

    To describe individuals' expectations, motivation, and satisfaction before, during, and after rehabilitation for ACL reconstruction and to explore how these factors were associated with return to pre-injury sport activity at 1-year follow-up. Sixty-five individuals (34 males), median age 22 (15-45) years, scheduled for ACL reconstruction participated. Participants completed the International Knee Documentation Committee Subjective Knee Form (IKDC-SKF) and questions about expectations, satisfaction, and motivation pre-operatively and at 16 and 52 weeks after surgery. Prior to surgery, 86 % of participants stated that their goal was to return to their pre-injury sport activity. Those who had returned to their pre-injury sport activity at 52 weeks were more motivated during rehabilitation to return to their pre-injury activity level, more satisfied with their activity level and knee function at 52 weeks, and scored significantly higher on the IKDC-SKF [median 92.0 (range 66.7-100.0)] at 52 weeks, compared to those who had not returned [median 77.6 (range 50.6-97.7)]. Prior to ACL reconstruction, most participants expected to return to their pre-injury activity level. Higher motivation during rehabilitation was associated with returning to the pre-injury sport activity. The participants who had returned to their pre-injury sport activity were more satisfied with their activity level and knee function 1 year after the ACL reconstruction. Facilitating motivation might be important to support individuals in achieving their participation goals after ACL reconstruction. Prospective cohort study, Level II.

  1. [Athletic performance, self-esteem and temperamental profile : Which relationship?].

    Science.gov (United States)

    Masmoudi, Jawaher; Trigui, Dorsa; Feki, Ines; Bâati, Imen; Jaoua, Abdelaziz

    2015-03-01

    Several authors emphasize the close relationship between self-esteem and athletic performance; such a relationship may raise the following question: by saying "strong" or "without any physical condition", is it a fair presentation of the individual's abilities or he reveals the most fundamental aspects of his personality, such as emotional temperament? To evaluate self-esteem, physical self and temperamental profile in a group of sportsmen, and to look for a relationship between these variables and athletic performance. We performed a cross-sectional, descriptive and analytic study in 80 young handball players of the "senior" category. We assessed self-esteem using the Rosenberg Self Esteem Scale, physical self-using the Physical Self-Inventory (PSI), and temperamental profile using the Temperament Evaluation of Memphis, Paris and San Diego Auto-questionnaire (TEMPS-A). Athletic performance was evaluated by the team coach by means of a score ranging from 1 to 10. High self-esteem was correlated to female gender (p=0.03), to an early start of physical activity (pself-esteem (pself-esteem (p=0.001). Good athletic performance was associated with hyperthymic (pself-esteem might help to achieve better athletic performance. In this intervention, the individual temperamental profile should be taken into account.

  2. Current Perspectives on Profiling and Enhancing Wheelchair Court Sport Performance.

    Science.gov (United States)

    Paulson, Thomas; Goosey-Tolfrey, Victoria

    2017-03-01

    Despite the growing interest in Paralympic sport, the evidence base for supporting elite wheelchair sport performance remains in its infancy when compared with able-bodied (AB) sport. Subsequently, current practice is often based on theory adapted from AB guidelines, with a heavy reliance on anecdotal evidence and practitioner experience. Many principles in training prescription and performance monitoring with wheelchair athletes are directly transferable from AB practice, including the periodization and tapering of athlete loads around competition, yet considerations for the physiological consequences of an athlete's impairment and the interface between athlete and equipment are vital when targeting interventions to optimize in-competition performance. Researchers and practitioners are faced with the challenge of identifying and implementing reliable protocols that detect small but meaningful changes in impairment-specific physical capacities and on-court performance. Technologies to profile both linear and rotational on-court performance are an essential component of sport-science support to understand sport-specific movement profiles and prescribe training intensities. In addition, an individualized approach to the prescription of athlete training and optimization of the "wheelchair-user interface" is required, accounting for an athlete's anthropometrics, sports classification, and positional role on court. In addition to enhancing physical capacities, interventions must focus on the integration of the athlete and his or her equipment, as well as techniques for limiting environmental influence on performance. Taken together, the optimization of wheelchair sport performance requires a multidisciplinary approach based on the individual requirements of each athlete.

  3. Low baseline (pre-injury) blood pressure predicts inpatient mortality in elderly trauma patients: A bi-institutional study.

    Science.gov (United States)

    Bohnen, Jordan D; Chang, David C; Ramly, Elie P; Olufajo, Olubode A; Le, Ryan T; Kaafarani, Haytham M A; Yeh, Daniel Dante; King, David R; Fagenholz, Peter J; Butler, Kathryn L; Askari, Reza; Salim, Ali; Velmahos, George C; de Moya, Marc

    2016-12-01

    The relationship between baseline (i.e., pre-injury) blood pressure and trauma outcomes in elderly patients is unknown. We therefore aimed to identify the independent impact of baseline systolic blood pressure (SBP) on inpatient mortality among elderly trauma patients. The 2004 to 2014 trauma registries of two Level I Trauma Centers were linked to electronic health records then reviewed to identify patients ≥65 years old with available baseline vital signs. Baseline SBP was defined as mean outpatient SBP within 2 years before injury. Trauma SBP was defined as first SBP reading after presentation for trauma. Baseline and Trauma SBP were classified as Low (Low, Normal, and High Baseline SBP groups, respectively (p = 0.001). In multivariable analyses, patients with Low Baseline SBP had significantly increased mortality risk [OR 3.19 (95% CI 1.62-6.26), p = 0.001] compared to patients with Normal Baseline SBP, in particular when they presented with Low Trauma SBP (Low Baseline SBP was particularly elevated among patients with a pre-existing diagnosis of hypertension [OR 4.78 (1.97-11.62), p = 0.001]. Low baseline pre-injury SBP is independently associated with more than a threefold increase in inpatient mortality among elderly trauma patients and a fivefold increase in mortality risk among patients with pre-existing hypertension. Given that blood pressure control in the elderly offers a long-term survival advantage, the paradoxical finding of decreased survival after trauma warrants further investigation. Prognostic/epidemiologic study, level III.

  4. Academic performance profiles: The importance of family expectations

    Directory of Open Access Journals (Sweden)

    Mónica Bravo Sanzana

    2017-07-01

    Full Text Available This study explored some of the factors that explain school performance. To attain this, Chilean students’ profiles of eighth year of primary school were identified and characterized (13.65 year old mean/ds 0.74. This was done according to their academic performance in the History, Ge­ography and Social Sciences test, and the context variables. The database was provided by the Sistema de Medición de la Calidad de la Educación de Chile (simce. The study was conducted by means of a predictive correlational quantitative design, using a classification and regression tree (cart. Parents’ high educational expectations are the most important distinguishing factor in school performance. The results are discussed in relation to previous research about these topics.

  5. Significant improvements in long trace profiler measurement performance

    Energy Technology Data Exchange (ETDEWEB)

    Takacs, P.Z. [Brookhaven National Lab., Upton, NY (United States); Bresloff, C.J. [Argonne National Lab., IL (United States)

    1996-07-01

    A Modifications made to the Long Trace Profiler (LTP II) system at the Advanced Photon Source at Argonne National Laboratory have significantly improved the accuracy and repeatability of the instrument The use of a Dove prism in the reference beam path corrects for phasing problems between mechanical efforts and thermally-induced system errors. A single reference correction now completely removes both error signals from the measured surface profile. The addition of a precision air conditioner keeps the temperature in the metrology enclosure constant to within {+-}0.1{degrees}C over a 24 hour period and has significantly improved the stability and repeatability of the system. We illustrate the performance improvements with several sets of measurements. The improved environmental control has reduced thermal drift error to about 0.75 microradian RMS over a 7.5 hour time period. Measurements made in the forward scan direction and the reverse scan direction differ by only about 0.5 microradian RMS over a 500mm, trace length. We are now able to put 1-sigma error bar of 0.3 microradian on an average of 10 slope profile measurements over a 500mm long trace length, and we are now able to put a 0.2 microradian error bar on an average of 10 measurements over a 200mm trace length. The corresponding 1-sigma height error bar for this measurement is 1.1 run.

  6. Preinjury and postinjury running analysis along with measurements of strength and tendon length in a patient with a surgically repaired Achilles tendon rupture.

    Science.gov (United States)

    Silbernagel, Karin Grävare; Willy, Richard; Davis, Irene

    2012-06-01

    Case report. The Achilles tendon is the most frequently ruptured tendon, and the incidence of Achilles tendon rupture has increased in the last decade. The rupture generally occurs without any preceding warning signs, and therefore preinjury data are seldom available. This case represents a unique opportunity to compare preinjury running mechanics with postinjury evaluation in a patient with an Achilles tendon rupture. A 23-year-old female sustained a right complete Achilles tendon rupture while playing soccer. Running mechanics data were collected preinjury, as she was a healthy participant in a study on running analysis. In addition, patient-reported symptoms, physical activity level, strength, ankle range of motion, heel-rise ability, Achilles tendon length, and running kinetics were evaluated 1 year after surgical repair. During running, greater ankle dorsiflexion and eversion and rearfoot abduction were noted on the involved side postinjury when compared to preinjury data. In addition, postinjury, the magnitude of all kinetics data was lower on the involved limb when compared to the uninvolved limb. The involved side displayed differences in strength, ankle range of motion, heel rise, and tendon length when compared to the uninvolved side 1 year after injury. Despite a return to normal running routine and reports of only minor limitations with running, considerable changes were noted in running biomechanics 1 year after injury. Calf muscle weakness and Achilles tendon elongation were also found when comparing the involved and uninvolved sides.

  7. The effect of pre-injury anti-platelet therapy on the development of complications in isolated blunt chest wall trauma: a retrospective study.

    Directory of Open Access Journals (Sweden)

    Ceri Battle

    Full Text Available INTRODUCTION: The difficulties in the management of the blunt chest wall trauma patient in the Emergency Department due to the development of late complications are well recognised in the literature. Pre-injury anti-platelet therapy has been previously investigated as a risk factor for poor outcomes following traumatic head injury, but not in the blunt chest wall trauma patient cohort. The aim of this study was to investigate pre-injury anti-platelet therapy as a risk factor for the development of complications in the recovery phase following blunt chest wall trauma. METHODS: A retrospective study was completed in which the medical notes were analysed of all blunt chest wall trauma patients presenting to a large trauma centre in Wales in 2012 and 2013. Using univariate and multivariable logistic regression analysis, pre-injury platelet therapy was investigated as a risk factor for the development of complications following blunt chest wall trauma. Previously identified risk factors were included in the analysis to address the influence of confounding. RESULTS: A total of 1303 isolated blunt chest wall trauma patients presented to the ED in Morriston Hospital in 2012 and 2013 with complications recorded in 144 patients (11%. On multi-variable analysis, pre-injury anti-platelet therapy was found to be a significant risk factor for the development of complications following isolated blunt chest wall trauma (odds ratio: 16.9; 95% confidence intervals: 8.2-35.2. As in previous studies patient age, number of rib fractures, chronic lung disease and pre-injury anti-coagulant use were also found to be significant risk factors. CONCLUSIONS: Pre-injury anti-platelet therapy is being increasingly used as a first line treatment for a number of conditions and there is a concurrent increase in trauma in the elderly population. Pre-injury anti-platelet therapy should be considered as a risk factor for the development of complications by clinicians managing

  8. The performance profile: A multi–criteria performance evaluation method for test–based problems

    Directory of Open Access Journals (Sweden)

    Jaśkowski Wojciech

    2016-03-01

    Full Text Available In test-based problems, solutions produced by search algorithms are typically assessed using average outcomes of interactions with multiple tests. This aggregation leads to information loss, which can render different solutions apparently indifferent and hinder comparison of search algorithms. In this paper we introduce the performance profile, a generic, domain-independent, multi-criteria performance evaluation method that mitigates this problem by characterizing the performance of a solution by a vector of outcomes of interactions with tests of various difficulty. To demonstrate the usefulness of this gauge, we employ it to analyze the behavior of Othello and Iterated Prisoner’s Dilemma players produced by five (coevolutionary algorithms as well as players known from previous publications. Performance profiles reveal interesting differences between the players, which escape the attention of the scalar performance measure of the expected utility. In particular, they allow us to observe that evolution with random sampling produces players coping well against the mediocre opponents, while the coevolutionary and temporal difference learning strategies play better against the high-grade opponents. We postulate that performance profiles improve our understanding of characteristics of search algorithms applied to arbitrary test-based problems, and can prospectively help design better methods for interactive domains.

  9. High performance thin layer chromatography profile of Cassytha filiformis

    Institute of Scientific and Technical Information of China (English)

    Mythili Sathiavelu; Sathiavelu Arunachalam

    2012-01-01

    Objective: To study the phenols, flavonoids, saponin profile of the medicinal plant Cassytha filiformis (C. filiformis) using high performance thin layer chromatography (HPTLC). Methods:The extracts were tested to determine the presence of various phytochmeicals like alkaloids, phenolic compounds, flavonoids, carbohydrates, glycosides, saponins, terpenoids, tannins, fixed oils, fats and protein and aminoacids (Harborne and Harborne, 1998). HPTLC studies were carried out by Harborne and Wagner et al method. Different compositions of the mobile phase for HPTLC analysis were tested in order to obtain high resolution and reproducible peaks. Results: The results of the preliminary phytochemical studies confirm the presence of phenols, alkaloids, carbohydrates, saponins, flavanoids, terpenoids and tannins in the methanolic extracts of C. filiformis. The methanolic extracts of C. filiformis displayed the presence of 13 types of phenolic substances with 13 different Rf values ranging from 0.01 to 0.96. The results illustrated the presence of 9 different types of flavonoides with 9 different Rf values ranging from 0.01 to 0.97. The results of HPTLC analysis of saponins demonstrated the presence of 11 different types of saponins with 11 different Rf values ranging from 0.04 to 0.92. Conclusions: In the present study we observed the phenols, flavonoids, saponin profile of the medicinal plant C. filiformis using high performance thin layer chromatography (HPTLC). Hence it was concluded that the phenolic compounds present in the methonolic extract could be responsible for antioxidant activities. Plant derived antioxidants, especially phenols and flavonoids, have been described to have various properties like anticancer, antiaging and prevention of cardiovascular diseases. Furthur, separation and characterization of the bioactive compound from the plant is to be evaluated and reported in near future.

  10. Effects of acute substance use and pre-injury substance abuse on traumatic brain injury severity in adults admitted to a trauma centre

    Directory of Open Access Journals (Sweden)

    Schanke Anne-Kristine

    2010-05-01

    Full Text Available Abstract Background The aims of this study were to describe the occurrence of substance use at the time of injury and pre-injury substance abuse in patients with moderate-to-severe traumatic brain injury (TBI. Effects of acute substance use and pre-injury substance abuse on TBI severity were also investigated. Methods A prospective study of 111 patients, aged 16-55 years, injured from May 2005 to May 2007 and hospitalised at the Trauma Referral Centre in Eastern Norway with acute TBI (Glasgow Coma Scale 3-12. Based on structural brain damages shown on a computed tomography (CT scan, TBI severity was defined by modified Marshall classification as less severe (score Results Forty-seven percent of patients were positive for substance use on admission to hospital. Significant pre-injury substance abuse was reported by 26% of patients. Substance use at the time of injury was more frequent in the less severe group (p = 0.01. The frequency of pre-injury substance abuse was higher in the more severe group (30% vs. 23%. In a logistic regression model, acute substance use at time of injury tended to decrease the probability of more severe intracranial injury, but the effect was not statistically significant after adjusting for age, gender, education, cause of injury and substance abuse, OR = 0.39; 95% CI 0.11-1.35, p = 0.14. Patients with positive screens for pre-injury substance abuse (CAGE ≥2 were more likely to have more severe TBI in the adjusted regression analyses, OR = 4.05; 95% CI 1.10-15.64, p = 0.04. Conclusions Acute substance use was more frequent in patients with less severe TBI caused by low-energy events such as falls, violence and sport accidents. Pre-injury substance abuse increased the probability of more severe TBI caused by high-energy trauma such as motor vehicle accidents and falls from higher levels. Preventive efforts to reduce substance consumption and abuse in at-risk populations are needed.

  11. Ergometric performance and cardiovascular profile of obesity clinic patients.

    Science.gov (United States)

    Giannakis, G; Thünenkötter, T; Weiler, B; Urhausen, A

    2014-01-01

    Aerobic exercise capacity is considered as an independent prognostic factor for cardiovascular disease and mortality. It is usually expressed in maximal oxygen consumption (VO2(max)) or metabolic equivalent (MET) and is measured by spiroergometry or calculated by a regression formula based on maximal performance achieved. Obesity is associated with reduced physical performance and increased cardiovascular mortality. The aim of our study was to describe the ergometric and cardiovascular profile of patients of an obesity clinic, and to compare a direct measure of VO2(max) with an indirect by a regression formula and to. 131 consecutive patients of an obesity clinic (95 females, 36 males) aged 16-75 years participated. The VO2(max) was measured by spiro-ergometry on a treadmill and estimated by a regression formula on the basis of the speed and grade of the treadmill. We have determined the relationship between Body mass index (BMI), Waist Circumference (WC) and the parameters VO2(max)/kg, MET, Performance Relative for Age, Heart Rate Recovery one minute after maximal effort (HRR), VO2(max) relative to a theoretical normal body weight (corresponding to a BMI of 25 kg/m2 (VO2(max)Rel25)), blood pressure, at rest and 5 minutes after exercise, Framingham Score and C-reactive protein (CRP). For the different age groups the VO2(max)/kg was below normal values (mean -23.4%). Measured VO2(max) was 15.2% lower than estimated by the regression formula. After adjusting to age and to a theoretical upper-limit normal body weight (corresponding to a BMI of 25 kg/m2) VO2(max)/kg was 5-20% (mean value 15%) higher than the reference values. VO2(max)/kg and HRR were correlated with BMI, WC and Framingham Score. 40% of the patients were already treated for hypertension, 55% had elevated blood pressure measurements at rest and 52% after exercise. Ergometric stress testing in obese subjects delivers important information that helps to evaluate the cardiovascular risk in this population

  12. Movement Profiles, Match Events, and Performance in Australian Football.

    Science.gov (United States)

    Johnston, Richard J; Watsford, Mark L; Austin, Damien J; Pine, Matthew J; Spurrs, Robert W

    2016-08-01

    Johnston, RJ, Watsford, ML, Austin, D, Pine, MJ, and Spurrs, RW. Movement profiles, match events, and performance in Australian football. J Strength Cond Res 30(8): 2129-2137, 2016-This study examined the relationship between movement demands, match events, and match performance in professional Australian football. Data were collected from 19 players using global positioning system units during 2 Australian Football League seasons. A range of movement demands and instantaneous power measures were collected. The players were divided into high-caliber (HC, ≥17/20) and low-caliber (LC, ≤8/20) groups based on the rating score by their coaches. A Mann-Whitney U-test, independent samples t-test, and effect sizes were used to determine whether any differences existed between the 2 groups. The HC group had a significantly higher match duration (7.2%), higher total distance (9.6%), and covered more distance and spent more time high-speed running per minute (12.7 and 11.9%). Although not significant, the effect sizes revealed that the HC group tended to have a higher mean metabolic power output (2.6%) and spent more time at the high power zone (7.9%). For the match event data, the HC group had significantly more involvements with the football. The results demonstrated the higher physical demands placed on the HC group. The findings suggest that analyzing instantaneous power measures can provide valuable information about the physical demands placed on team sport athletes to coaches and conditioning staff.

  13. Systematic Review and Meta-Analysis: Is Pre-Injury Antiplatelet Therapy Associated with Traumatic Intracranial Hemorrhage?

    Science.gov (United States)

    van den Brand, Crispijn L; Tolido, Tanya; Rambach, Anna H; Hunink, Myriam G M; Patka, Peter; Jellema, Korné

    2017-01-01

    The objective of this systematic review and meta-analysis is to evaluate whether the pre-injury use of antiplatelet therapy (APT) is associated with increased risk of traumatic intracranial hemorrhage (tICH) on CT scan. PubMed, Medline, Embase, Cochrane Central, reference lists, and national guidelines on traumatic brain injury were used as data sources. Eligible studies were cohort studies and case-control studies that assessed the relationship between APT and tICH. Studies without control group were not included. The primary outcome of interest was tICH on CT. Two reviewers independently selected studies, assessed methodological quality, and extracted outcome data. This search resulted in 10 eligible studies with 20,247 patients with head injury that were included in the meta-analysis. The use of APT in patients with head injury was associated with significant increased risk of tICH compared with control (odds ratio [OR] 1.87, 95% confidence interval [CI]1.27-2.74). There was significant heterogeneity in the studies (I(2) 84%), although almost all showed an association between APT use and tICH. This association could not be established for patients receiving aspirin monotherapy. When considering only patients with mild traumatic brain injury (mTBI), the OR is 2.72 (95% CI 1.92-3.85). The results were robust to sensitivity analysis on study quality. In summary, APT in patients with head injury is associated with increased risk of tICH; this association is most relevant in patients with mTBI. Whether this association is the result of a causal relationship and whether this relationship also exists for patients receiving aspirin monotherapy cannot be established with the current review and meta-analysis.

  14. Performance profiles of exterior fire protective building envelopes

    Directory of Open Access Journals (Sweden)

    Jarnskjold Tobias

    2016-01-01

    Full Text Available The fire protective envelope of any building consists of multiple elements with widely differing properties relating to a fire, such as glass, roof tiles and sheathings, wood cladding, gaps and openings. Where resistance to an exterior fire is required, all elements should be verified to provide a comparable risk of burn-through. Elements are rated by either the material response to fire or fire resistance. In Europe, cladding sheets and wall membranes can be rated by K classes, which effectively include a measure of the time to burn through. A determination of burn-through time of each element of a specific building envelope should be obtained. A design tool to verify the performance of a building's fire protective envelope has been developed. In this paper, a general description of passive elements of the envelope, which should be included in a risk assessment tool such as an index method, is presented. An illustrative approach to visualise the profiles for areas densely spaced structures where an exterior fire may trigger building-to-building fire spread is also included. The research is based on the hypothesis that a relatively subtle and pointed upgrading of an exterior building envelope will severely reduce the speed of building-to-building fire spread, thus allowing firefighting efforts to get on top of the situation. For a burning structure to expose other buildings to fire, the fire has to settle, which leads to a burn-through to the inside. Once inside, an enclosure fire needs to develop and burn through the roof or break one or more large window panes. It is estimated that a 5–10 min delay for a structure to expose other structures to fire can be sufficient to avoid loss of multiple structures. A 10–50 min burn-through time allows for an extended intervention by the fire brigade, which is significant in rural areas. A fire protective envelope may prevent an exterior fire from penetrating the protective envelope at all and the

  15. Musculoskeletal performance testing and profiling of elite competitive fencers.

    Science.gov (United States)

    Sapega, A A; Minkoff, J; Valsamis, M; Nicholas, J A

    1984-01-01

    Twenty-four male members of the 1976 United States Olympic Fencing Squad were profiled. Data were collected on anthropometry; flexibility; and muscular strength, endurance, and power. Five of the physical variables measured in the laboratory were shown to have a significant relationship to competitive success.

  16. Biomarkers of Fatigue: Metabolomics Profiles Predictive of Cognitive Performance

    Science.gov (United States)

    2013-05-01

    demonstrated urinary metabolite profiles that were similar to the other two classification groups at 0 h and was found to be intermittent between the other...Tyrosine administration prevents hypoxia -induced decrements in learning and memory. Physiol. Behav. 59, 867-871. Shurtleff, D., Thomas, JR

  17. Technical player profiles related to the physical fitness of young female volleyball players predict team performance.

    Science.gov (United States)

    Dávila-Romero, C; Hernández-Mocholí, M A; García-Hermoso, A

    2015-03-01

    This study is divided into three sequential stages: identification of fitness and game performance profiles (individual player performance), an assessment of the relationship between these profiles, and an assessment of the relationship between individual player profiles and team performance during play (in championship performance). The overall study sample comprised 525 (19 teams) female volleyball players aged 12-16 years and a subsample (N.=43) used to examine study aims one and two was selected from overall sample. Anthropometric, fitness and individual player performance (actual game) data were collected in the subsample. These data were analyzed through clustering methods, ANOVA and independence chi-square test. Then, we investigated whether the proportion of players with the highest individual player performance profile might predict a team's results in the championship. Cluster analysis identified three volleyball fitness profiles (high, medium, and low) and two individual player performance profiles (high and low). The results showed a relationship between both types of profile (fitness and individual player performance). Then, linear regression revealed a moderate relationship between the number of players with a high volleyball fitness profile and a team's results in the championship (R2=0.23). The current study findings may enable coaches and trainers to manage training programs more efficiently in order to obtain tailor-made training, identify volleyball-specific physical fitness training requirements and reach better results during competitions.

  18. Serum Protein Profile Study of Clinical Samples Using High Performance Liquid Chromatography-Laser Induced Fluorescence

    DEFF Research Database (Denmark)

    Karemore, Gopal Raghunath; Ukendt, Sujatha; Rai, Lavanya

    2009-01-01

    The serum protein profiles of normal subjects, patients diagnosed with cervical cancer, and oral cancer were recorded using High Performance Liquid Chromatography combined with Laser Induced Fluorescence detection (HPLC-LIF). Serum protein profiles of the above three classes were tested for estab......The serum protein profiles of normal subjects, patients diagnosed with cervical cancer, and oral cancer were recorded using High Performance Liquid Chromatography combined with Laser Induced Fluorescence detection (HPLC-LIF). Serum protein profiles of the above three classes were tested...... for establishing the ability of HPLC-LIF protein profiling technique for discrimination, using hard clustering and Fuzzy clustering methods. The clustering algorithms have quite successfully classified the profiles as belonging to normal, cancer of cervix, and oral cancer conditions....

  19. Profiles of mental health care professionals based on work role performance.

    Science.gov (United States)

    Markon, Marie-Pierre; Bamvita, Jean-Marie; Chiocchio, François; Fleury, Marie-Josée

    2017-02-18

    The worldwide burden of mental disorders is considerable, and on the rise, putting pressure on health care systems. Current reforms aim to improve the efficiency of mental health care systems by increasing service integration in communities and strengthening primary mental health care. In this context, mental health care professionals (MHPs) are increasingly required to work on interdisciplinary teams in a variety of settings. Little is known, however, about the profiles of MHPs in relation to their perceived work role performance. MHPs in Quebec (N = 315) from four local service networks completed a self-administered questionnaire eliciting information on individual and team characteristics, as well as team processes and states. Profiles of MHPs were created using a two-step cluster analysis. Five profiles were generated. MHPs belonging to profiles labelled senior medical outpatient specialized care MHPs and senior psychosocial outpatient specialized care MHPs perceived themselves as more performing than MHPs in other profiles. The profile labelled low-collaborators was significantly less performing than all other groups. Two other profiles were identified, positioned between the aforementioned groups in terms of the perceived performance of MHPs: the junior primary care MHPs and the diversified specialized care MHPs. Seniority within the team, delivering specialized type of care, and positive team processes were all features associated with profiles where perceived work performance was high. Overall, this study supports the case for initiatives aimed at improving stability and interdisciplinary collaboration in health teams, especially in primary care.

  20. General Video Game Evaluation Using Relative Algorithm Performance Profiles

    DEFF Research Database (Denmark)

    Nielsen, Thorbjørn; Barros, Gabriella; Togelius, Julian;

    2015-01-01

    In order to generate complete games through evolution we need generic and reliably evaluation functions for games. It has been suggested that game quality could be characterised through playing a game with different controllers and comparing their performance. This paper explores that idea through...... investigating the relative performance of different general game-playing algorithms. Seven game-playing algorithms was used to play several hand-designed, mutated and randomly generated VGDL game descriptions. Results discussed appear to support the conjecture that well-designed games have, in average, a higher...... performance difference between better and worse game-playing algorithms....

  1. Potential Performance Criteria for Combat Ration Packs - Texture Profile Analysis

    Science.gov (United States)

    2014-11-01

    at which sensory texture is no longer acceptable. A study designed to elicit this information would be required before performance criteria based on...TPA are discussed. UNCLASSIFIED UNCLASSIFIED 3. Significant changes in texture were observed for golden and chocolate self-saucing puddings and...establish texture-based performance criteria should focus initially on golden and chocolate self-saucing puddings and biscuits. 2. Investigate the

  2. The Impact of a Performance Profiling Intervention on Athletes' Intrinsic Motivation

    Science.gov (United States)

    Weston, Neil J. V.; Greenlees, Iain A.; Thelwell, Richard C.

    2011-01-01

    Originally developed by Butler (1989) with the Great Britain Olympic boxing team, performance profiling is an assessment tool primarily used by sport psychologists to enhance athlete awareness. The completed profile provides the athlete, the coach, and psychologist with a visual representation of the athlete's perception of his or her performance…

  3. The Impact of a Performance Profiling Intervention on Athletes' Intrinsic Motivation

    Science.gov (United States)

    Weston, Neil J. V.; Greenlees, Iain A.; Thelwell, Richard C.

    2011-01-01

    Originally developed by Butler (1989) with the Great Britain Olympic boxing team, performance profiling is an assessment tool primarily used by sport psychologists to enhance athlete awareness. The completed profile provides the athlete, the coach, and psychologist with a visual representation of the athlete's perception of his or her performance…

  4. Comparative assessment of performance and genome dependence among phylogenetic profiling methods

    Directory of Open Access Journals (Sweden)

    Wu Jie

    2006-09-01

    Full Text Available Abstract Background The rapidly increasing speed with which genome sequence data can be generated will be accompanied by an exponential increase in the number of sequenced eukaryotes. With the increasing number of sequenced eukaryotic genomes comes a need for bioinformatic techniques to aid in functional annotation. Ideally, genome context based techniques such as proximity, fusion, and phylogenetic profiling, which have been so successful in prokaryotes, could be utilized in eukaryotes. Here we explore the application of phylogenetic profiling, a method that exploits the evolutionary co-occurrence of genes in the assignment of functional linkages, to eukaryotic genomes. Results In order to evaluate the performance of phylogenetic profiling in eukaryotes, we assessed the relative performance of commonly used profile construction techniques and genome compositions in predicting functional linkages in both prokaryotic and eukaryotic organisms. When predicting linkages in E. coli with a prokaryotic profile, the use of continuous values constructed from transformed BLAST bit-scores performed better than profiles composed of discretized E-values; the use of discretized E-values resulted in more accurate linkages when using S. cerevisiae as the query organism. Extending this analysis by incorporating several eukaryotic genomes in profiles containing a majority of prokaryotes resulted in similar overall accuracy, but with a surprising reduction in pathway diversity among the most significant linkages. Furthermore, the application of phylogenetic profiling using profiles composed of only eukaryotes resulted in the loss of the strong correlation between common KEGG pathway membership and profile similarity score. Profile construction methods, orthology definitions, ontology and domain complexity were explored as possible sources of the poor performance of eukaryotic profiles, but with no improvement in results. Conclusion Given the current set of

  5. Compressive sensing for high resolution profiles with enhanced Doppler performance

    NARCIS (Netherlands)

    Anitori, L.; Hoogeboom, P.; Chevalier, F. Le; Otten, M.P.G.

    2012-01-01

    In this paper we demonstrate how Compressive Sensing (CS) can be used in pulse-Doppler radars to improve the Doppler performance while preserving range resolution. We investigate here two types of stepped frequency waveforms, the coherent frequency bursts and successive frequency ramps, which can be

  6. General Video Game Evaluation Using Relative Algorithm Performance Profiles

    DEFF Research Database (Denmark)

    Nielsen, Thorbjørn; Barros, Gabriella; Togelius, Julian;

    2015-01-01

    In order to generate complete games through evolution we need generic and reliably evaluation functions for games. It has been suggested that game quality could be characterised through playing a game with different controllers and comparing their performance. This paper explores that idea throug...

  7. Building America Top Innovations 2013 Profile – HPXML: A Standardized Home Performance Data Sharing System

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2013-09-01

    This Top Innovation profile describes the Standard for Home Performance-Related Data Transfer (known as HPXML), developed by the National Renewable Energy Laboratory, which facilitates smooth communication between program tracking systems and energy upgrade analysis software,

  8. A Profile of Fitness Parameters and Performance of Volleyball Players

    Directory of Open Access Journals (Sweden)

    Govind B. Taware

    2013-07-01

    Full Text Available Background: Ball games require comprehen-sive ability including physical, technical, men-tal and tactical abilities. Among them, physicalabilities of players exert marked effects on theskill of the players themselves and the tacticsof the team. Therefore players must have thephysical abilities to meet the demand of thesport. Volleyball is one of the most popularlyplayed games in the world. Unfortunately, thelevel of performance of the Indian volleyballplayers lags far behind the international stan-dards. Aim of the Study: The present study wasaimed to assess flexibility, muscular endurance,power and cardio-respiratory endurance of vol-leyball players and to compare the results withage matched controls. Also, to compare thefindings of the volleyball players with that ofthe international norms from the available lit-erature and to make some suggestions for theimprovement in their performance level. Ma-terial and Methods: The study was carried outin 40 male volleyball players aged between 17to 26 years and 40 ages matched male controls.Physical fitness parameters namely flexibility,muscular endurance, power and cardio-respi-ratory endurance were measured, data was ana-lyzed using unpaired ‘t’-test. Results: It was ob-served that all physical fitness parameters weresignificantly more in players as compared totheir aged-matched controls but when values ofthe subjects were compared to internationalstandards; our subjects were behind the recom-mended norms for the elite volleyball players.Conclusion: The volleyball players have moreadvantage of flexibility muscular endurance,power and cardio-respiratory endurance.

  9. Performance Outcomes After Metacarpal Fractures in National Basketball Association Players.

    Science.gov (United States)

    Guss, Michael S; Begly, John P; Ramme, Austin J; Hinds, Richard M; Karia, Raj J; Capo, John T

    2016-12-01

    Background: The aim was to determine whether players in the National Basketball Association (NBA) who sustain metacarpal fractures demonstrate decreased performance upon return to competition when compared with their performance before injury and that of their control-matched peers. Methods: Data for 32 NBA players with metacarpal fractures incurred over 11 seasons (2002-2003 to 2012-2013) were obtained from injury reports, press releases, and player profiles (www.nba.com and www.basketballreference.com). Player age, body mass index (BMI), position, shooting hand, number of years in the league, and treatment (surgical vs nonsurgical) were recorded. Individual season statistics for the 2 seasons immediately prior to injury and the 2 seasons after injury, including player efficiency rating (PER), were obtained. Thirty-two controls matched by player position, age, and performance statistics were identified. A performance comparison of the cohorts was performed. Results: Mean age at the time of injury was 27 years with an average player BMI of 24. Players had a mean 5.6 seasons of NBA experience prior to injury. There was no significant change in PER when preinjury and postinjury performances were compared. Neither injury to their shooting hand nor operative management of the fracture led to a decrease in performance during the 2 seasons after injury. When compared with matched controls, no significant decline in performance in PER the first season and second season after injury was found. Conclusion: NBA players sustaining metacarpal fractures can reasonably expect to return to their preinjury performance levels following appropriate treatment.

  10. Opposing effects of traumatic brain injury on excitatory synaptic function in the lateral amygdala in the absence and presence of preinjury stress.

    Science.gov (United States)

    Klein, Rebecca C; Acheson, Shawn K; Qadri, Laura H; Dawson, Alina A; Rodriguiz, Ramona M; Wetsel, William C; Moore, Scott D; Laskowitz, Daniel T; Dawson, Hana N

    2016-06-01

    Traumatic brain injury (TBI) is a leading cause of death and disability among young adults and is highly prevalent among recently deployed military personnel. Survivors of TBI often experience cognitive and emotional deficits, suggesting that long-term effects of injury may disrupt neuronal function in critical brain regions, including the amygdala, which is involved in emotion and fear memory. Amygdala hyperexcitability has been reported in both TBI and posttraumatic stress disorder patients, yet little is known regarding the effects of combined stress and TBI on amygdala structure and function at the neuronal level. The present study seeks to determine how the long-term effects of preinjury foot-shock stress and TBI interact to influence synaptic plasticity in the lateral amygdala (LA) of adult male C57BL/6J mice by using whole-cell patch clamp electrophysiology 2-3 months postinjury. In the absence of stress, TBI resulted in a significant increase in membrane excitability and spontaneous excitatory postsynaptic currents (sEPSCs) in LA pyramidal-like neurons. Foot-shock stress in the absence of TBI also resulted in increased sEPSC activity. In contrast, when preinjury stress and TBI occurred in combination, sEPSC activity was significantly decreased compared with either condition alone. There were no significant differences in inhibitory activity or total dendritic length among any of the treatment groups. These results demonstrate that stress and TBI may be contributing to amygdala hyperexcitability via different mechanisms and that these pathways may counterbalance each other with respect to long-term pathophysiology in the LA.

  11. Analysis of lipoprotein profiles of healthy cats by gel-permeation high-performance liquid chromatography.

    Science.gov (United States)

    Mizutani, Hisashi; Sako, Toshinori; Okuda, Hiroko; Arai, Nobuaki; Kuriyama, Koji; Mori, Akihiro; Yoshimura, Itaru; Koyama, Hidekazu

    2016-09-01

    Density gradient ultracentrifugation (DGUC) and gel electrophoresis are conventionally used to obtain lipoprotein profiles of animals. We recently applied high-performance liquid chromatography with a gel permeation column (GP-HPLC) and an on-line dual enzymatic system to dogs for lipoprotein profile analysis. We compared the GP-HPLC with DGUC as a method to obtain a feline lipoprotein profile. The lipoprotein profiles showed large and small peaks, which corresponded to high-density lipoprotein (HDL) and low-density lipoprotein (LDL), respectively, whereas very low-density lipoprotein (VLDL) and chylomicron (CM) were only marginally detected. This profile was very similar to that of dogs reported previously. Healthy cats also had a small amount of cholesterol-rich particles distinct from the normal LDL or HDL profile. There was no difference in lipoprotein profiles between the sexes, but males had a significantly larger LDL particle size (P=0.015). This study shows the feasibility of GP-HPLC for obtaining accurate lipoprotein profiles with small sample volumes and provides valuable reference data for healthy cats that should facilitate diagnoses.

  12. Bank Diversification Effects on Bank Performance and Risk Profile of Bank in Indonesia

    Directory of Open Access Journals (Sweden)

    Anthony Lukmawijaya

    2015-05-01

    Full Text Available We investigate the relationship of Indonesian bank diversification towards its long term performance and risk profile with Indonesian bank data from 2009 to 2013. Non-interest income to total operating income of the bank measures its bank diversification level. Bank value is measured by the adjusted Tobin's Q and risk profile which is broken down into total risk, idiosyncratic risk, and systematic risk. The result shows that bank non-interest income diversification has a positive influence on its franchise value. There is, however, no strong evidence that diversification can lower a bank's risk profile.

  13. Force-velocity profile: imbalance determination and effect on lower limb ballistic performance.

    Science.gov (United States)

    Samozino, P; Edouard, P; Sangnier, S; Brughelli, M; Gimenez, P; Morin, J-B

    2014-06-01

    This study sought to lend experimental support to the theoretical influence of force-velocity (F-v) mechanical profile on jumping performance independently from the effect of maximal power output (P max ). 48 high-level athletes (soccer players, sprinters, rugby players) performed maximal squat jumps with additional loads from 0 to 100% of body mass. During each jump, mean force, velocity and power output were obtained using a simple computation method based on flight time, and then used to determine individual linear F-v relationships and P max values. Actual and optimal F-v profiles were computed for each subject to quantify mechanical F-v imbalance. A multiple regression analysis showed, with a high-adjustment quality (r²=0.931, Pperformance (Pballistic performance depends, in addition to P max , on the F-v profile of lower limbs. This adds support to the actual existence of an individual optimal F-v profile that maximizes jumping performance, a F-v imbalance being associated to a lower performance. These results have potential strong applications in the field of strength and conditioning.

  14. Performance and Comparison of Lithium-Ion Batteries Under Low-Earth-Orbit Mission Profiles

    Science.gov (United States)

    Reid, Concha M.; Smart, Marshall C.; Bugga, Ratnakumar V.; Manzo, Michelle A.; Miller, Thomas B.; Gitzendanner, Rob

    2007-01-01

    The performance of two 28 V, 25 Ah lithium-ion batteries is being evaluated under low-Earth-orbit mission profiles for satellite and orbiter applications. The batteries are undergoing life testing and have achieved over 12,000 cycles to 40 percent depth-of-discharge.

  15. Pre-injury neuro-psychiatric medication use, alone or in combination with cardiac medications, may affect outcomes in trauma patients

    Directory of Open Access Journals (Sweden)

    J R Wisler

    2014-01-01

    Full Text Available Background: Recent review of older (≥45-years-old patients admitted to our trauma center showed that more than one-third were using neuro-psychiatric medications (NPMs prior to their injury-related admission. Previously published data suggests that use of NPMs may increase patients′ risk and severity of injury. We sought to examine the impact of pre-injury NPM use on older trauma patients′ morbidity and mortality. Materials and Methods: Retrospective record review included medication regimen characteristics and NPM use (antidepressants-AD, antipsychotics-AP, anxiolytics-AA. Hospital morbidity, mortality, and 90-day survival were examined. Comparisons included regimens involving NPMs, further focusing on their interactions with various cardiac medications (beta blocker - BB; angiotensin-converting enzyme inhibitor/angiotensin receptor blocker - ACE/ARB; calcium channel blocker - CCB. Results: 712 patient records were reviewed (399 males, mean age 63.5 years, median ISS 8. 245 patients were taking at least 1 NPM: AD (158, AP (35, or AA (108 before injury. There was no effect of NPM monotherapy on hospital mortality. Patients taking ≥3 NPMs had significantly lower 90-day survival compared to patients taking ≤2 NPMs (81% for 3 or more NPMs, 95% for no NPMs, and 89% 1-2 NPMs, P < 0.01. Several AD-cardiac medication (CM combinations were associated with increased mortality compared to monotherapy with either agent (BB-AD 14.7% mortality versus 7.0% for AD monotherapy or 4.8% BB monotherapy, P < 0.05. Combinations of ACE/ARB-AA were associated with increased mortality compared to ACE/ARB monotherapy (11.5% vs 4.9, P = 0.04. Finally, ACE/ARB-AD co-administration had higher mortality than ACE/ARB monotherapy (13.5% vs 4.9%, P = 0.01. Conclusions: Large proportion of older trauma patients was using pre-injury NPMs. Several regimens involving NPMs and CMs were associated with increased in-hospital mortality. Additionally, use of ≥3 NPMs was

  16. DVB-T/H Portable and Mobile TV Performance in the New Channel Profiles Modes

    Science.gov (United States)

    Kratochvíl, Tomáš

    This paper deals with an experimental laboratory assessment of new channel profile modes in the transmission of DVB-T/H portable and mobile TV over fading channels. These new profiles called PI (Pedestrian Indoor), PO (Pedestrian Outdoor), VU (Vehicular Urban) and MR (Motorway Rural) are originally from the Celtic Wing TV project. The DVB-T/H performance was tested in a laboratory environment using R&S test and measurements equipments. The results of the BER before and BER after Viterbi decoding and MER (Modulation Error Rate) were evaluated as the objective criteria for the DVB-T/H portable and mobile TV reception.

  17. Profiling high performance dense linear algebra algorithms on multicore architectures for power and energy efficiency

    KAUST Repository

    Ltaief, Hatem

    2011-08-31

    This paper presents the power profile of two high performance dense linear algebra libraries i.e., LAPACK and PLASMA. The former is based on block algorithms that use the fork-join paradigm to achieve parallel performance. The latter uses fine-grained task parallelism that recasts the computation to operate on submatrices called tiles. In this way tile algorithms are formed. We show results from the power profiling of the most common routines, which permits us to clearly identify the different phases of the computations. This allows us to isolate the bottlenecks in terms of energy efficiency. Our results show that PLASMA surpasses LAPACK not only in terms of performance but also in terms of energy efficiency. © 2011 Springer-Verlag.

  18. Effect of Multi-repair Welding on Fatigue Performance of Aluminum Alloy Profile Welded Joint

    Science.gov (United States)

    Diao, You-De; Shi, Chun-Yuan; Tian, Hong-Lei

    2016-05-01

    Aluminum alloy profile has been widely used in the manufacture of the rail vehicles. But it's necessary for the repair welding of the welded joints to be conducted because some defects exist in the weld such as porosity, inclusions and incomplete penetrations in the welding processes. In this paper, the influence of the multi-repair welding of 6005A aluminum alloy profile butt welded joints on the fatigue performance are investigated based on the results of fatigue tests. The parameters of curves and the fatigue strength of the welded joints are calculated, and Goodman fatigue limit diagram is also obtained. The results show that fatigue strength of aluminum alloy profile butt welded joints, in condition of 107 cycle life, meet the standard requirement for the as-welded, repair welded state one time or two times respectively.

  19. Influence of an imperfect energy profile on a seeded free electron laser performance

    Directory of Open Access Journals (Sweden)

    Botao Jia

    2010-06-01

    Full Text Available A single-pass high-gain x-ray free electron laser (FEL calls for a high quality electron bunch. In particular, for a seeded FEL amplifier and for a harmonic generation FEL, the electron bunch initial energy profile uniformity is crucial for generating an FEL with a narrow bandwidth. After the acceleration, compression, and transportation, the electron bunch energy profile entering the undulator can acquire temporal nonuniformity. We study the influence of the electron bunch initial energy profile nonuniformity on the FEL performance. Intrinsically, for a harmonic generation FEL, the harmonic generation FEL in the final radiator starts with an electron bunch having energy modulation acquired in the previous stages, due to the FEL interaction at those FEL wavelengths and their harmonics. The influence of this electron bunch energy nonuniformity on the harmonic generation FEL in the final radiator is then studied.

  20. Keeping on track: performance profiles of low performers in a stratified educational system

    NARCIS (Netherlands)

    Reed, Helen C.; van Wesel, F.; Ouwehand, Carolijn; Jolles, Jelle

    2015-01-01

    In countries with high differentiation between academic and vocational education, an individual’s future prospects are strongly determined by the educational track to which he or she is assigned. This large-scale, cross-sectional study focuses on low-performing students in academic tracks who face b

  1. Performance Variations in Profiling Mysql Server on the Xen Platform: Is It Xen or Mysql?

    Directory of Open Access Journals (Sweden)

    Ashish Tapdiya

    2014-04-01

    Full Text Available Reliability of a performance model is quintessential to the robust resource management of applications on the cloud platform. Existing studies show that the contention for shared I/O induces temporal perfor mance variations in a guest VM and heterogeneity in the underlying hardware leads to rel ative performance difference between guest VMs of the same abstract type. In this work, we demonstrate that a guest VM exhibits significant performance variations across repeated runs in spite of contention free hosting of a single guest VM on a physical m achine. Also, notable performance difference between guest VMs created equal on physical machines of a homogeneous cluster is noticed. Systematic examination of the compon ents involved in the request processing identifies disk I/O as the source of variatio ns. Further investigation establishes that the root cause of the variations is linked with how MySQL manages the storage of ta bles and indexes on the guest VM's disk file system. The observed variations in performance raise the cha llenge of creating a cons istent and repeatable profile. To this end, we present and evaluate a black box approach based on database population from a snapshot to reduce the perceived performance variations. The experimental results show that the profile created for a database popu lated using a snapshot can be used fo r performance modeling up to 80 % CPU utilization. We validate our findings on the Amazon EC2 cloud platform.

  2. Return to Play and Performance After Jones Fracture in National Basketball Association Athletes.

    Science.gov (United States)

    Begly, John P; Guss, Michael; Ramme, Austin J; Karia, Raj; Meislin, Robert J

    2016-07-01

    Basketball players are at risk for foot injuries, including Jones fractures. It is unknown how this injury affects the future play and performance of athletes. National Basketball Association (NBA) players who sustain Jones fractures of the base of the fifth metatarsal have high rates of return to play and do not experience a decrease in performance on return to competition when compared with preinjury and with control-matched peers. Retrospective cohort study. Level 5. Data on 26 elite basketball players with Jones fractures over 19 NBA seasons (1994-1995 to 2012-2013) were obtained from injury reports, press releases, player profiles, and online public databases. Variables included age, body mass index (BMI), player position, experience, and surgical treatment. Individual season statistics pre- and postinjury were collected. Twenty-six controls were identified by matched player position, age, and performance statistics. The mean age at the time of injury was 24.8 years, mean BMI was 24.7 kg/m(2), and the mean experience prior to injury was 4.1 NBA seasons. Return to previous level of competition was achieved by 85% of athletes. There was no change in player efficiency rating (PER) when pre- and postinjury performance was compared. When compared with controls, no decline in PER measured performance was identified. The majority of NBA players sustaining a Jones fracture return to their preinjury level of competition. These elite athletes demonstrate no decrease in performance on their return to play. Jones fractures are well-studied injuries in terms of etiology, diagnosis, and management. However, the effect of these injuries on future performance of athletes is unknown. Using the findings of our study, orthopaedic surgeons may be better prepared to counsel and educate elite athletes who sustain a Jones fracture. © 2015 The Author(s).

  3. Panel performance: Modelling variation in sensory profiling data by multiway analysis

    OpenAIRE

    Romano, Rosaria; Vestergaard, Jannie S.; Bredie, Wender L. P.

    2009-01-01

    Sensory profiling data is essentially three-way data where samples, attributes and assessors are the three dimensions of information. It is common practice to average over the assessors and focus the analysis on the relations between samples and sensory descriptors. However, since assessor reliability can not be controlled in advance, posthoc analysis on assessors is needed to assess performance of the individual and at the panel level. For this purpose, multiway analysis is a very efficient ...

  4. Validation of vertical refractivity profiles as required for performance prediction of coastal surveillance radars

    CSIR Research Space (South Africa)

    Naicker, K

    2011-04-01

    Full Text Available for modeling the detection performance of coastal surveillance radars. Validation is provided through meteorological and radio wave propagation measurements undertaken in False Bay, South Africa. Keywords-vertical refractive profiles, evaporation ducts.... An atmospheric duct is a horizontal layer in troposphere, where the refractive conditions are such that an EM wave will be channeled or guided as discussed above. This results in EM wave propagation over great ranges. In a littoral environment, evaporation...

  5. Interpersonal value profiles and analysis of adolescent academic performance and social thinking

    OpenAIRE

    José J. Gázquez; Sainz, Jorge; Pérez-Fuentes, María del C.; Molero, María del M.; Soler, Francisco J.

    2015-01-01

    The purposes of this study were to identify interpersonal value profiles and find out whether there were any differences in academic performance and social thinking. The study sample was 885 high school students of whom 49.8% (N = 441) were boys and 50.2% (N = 444) were girls. The results show that students with low Benevolence and Conformity levels showed higher prevalence of failures and repeated the year more often. Furthermore, students with a high level of Recognition and Leadership and ...

  6. Linking Hydrolysis Performance to Trichoderma reesei Cellulolytic Enzyme Profile

    DEFF Research Database (Denmark)

    Lehmann, Linda Olkjær; Petersen, Nanna; I. Jørgensen, Christian;

    2016-01-01

    Trichoderma reesei expresses a large number of enzymes involved in lignocellulose hydrolysis and the mechanism of how these enzymes work together is too complex to study by traditional methods, e.g. by spiking with single enzymes and monitoring hydrolysis performance. In this study a multivariate...... approach, partial least squares regression, was used to see if it could help explain the correlation between enzyme profile and hydrolysis performance. Diverse enzyme mixtures were produced by Trichoderma reesei Rut-C30 by exploiting various fermentation conditions and used for hydrolysis of washed...

  7. Performance comparison of digital microRNA profiling technologies applied on human breast cancer cell lines.

    Directory of Open Access Journals (Sweden)

    Erik Knutsen

    Full Text Available MicroRNA profiling represents an important first-step in deducting individual RNA-based regulatory function in a cell, tissue, or at a specific developmental stage. Currently there are several different platforms to choose from in order to make the initial miRNA profiles. In this study we investigate recently developed digital microRNA high-throughput technologies. Four different platforms were compared including next generation SOLiD ligation sequencing and Illumina HiSeq sequencing, hybridization-based NanoString nCounter, and miRCURY locked nucleic acid RT-qPCR. For all four technologies, full microRNA profiles were generated from human cell lines that represent noninvasive and invasive tumorigenic breast cancer. This study reports the correlation between platforms, as well as a more extensive analysis of the accuracy and sensitivity of data generated when using different platforms and important consideration when verifying results by the use of additional technologies. We found all the platforms to be highly capable for microRNA analysis. Furthermore, the two NGS platforms and RT-qPCR all have equally high sensitivity, and the fold change accuracy is independent of individual miRNA concentration for NGS and RT-qPCR. Based on these findings we propose new guidelines and considerations when performing microRNA profiling.

  8. Performance comparison of digital microRNA profiling technologies applied on human breast cancer cell lines.

    Science.gov (United States)

    Knutsen, Erik; Fiskaa, Tonje; Ursvik, Anita; Jørgensen, Tor Erik; Perander, Maria; Lund, Eiliv; Seternes, Ole Morten; Johansen, Steinar D; Andreassen, Morten

    2013-01-01

    MicroRNA profiling represents an important first-step in deducting individual RNA-based regulatory function in a cell, tissue, or at a specific developmental stage. Currently there are several different platforms to choose from in order to make the initial miRNA profiles. In this study we investigate recently developed digital microRNA high-throughput technologies. Four different platforms were compared including next generation SOLiD ligation sequencing and Illumina HiSeq sequencing, hybridization-based NanoString nCounter, and miRCURY locked nucleic acid RT-qPCR. For all four technologies, full microRNA profiles were generated from human cell lines that represent noninvasive and invasive tumorigenic breast cancer. This study reports the correlation between platforms, as well as a more extensive analysis of the accuracy and sensitivity of data generated when using different platforms and important consideration when verifying results by the use of additional technologies. We found all the platforms to be highly capable for microRNA analysis. Furthermore, the two NGS platforms and RT-qPCR all have equally high sensitivity, and the fold change accuracy is independent of individual miRNA concentration for NGS and RT-qPCR. Based on these findings we propose new guidelines and considerations when performing microRNA profiling.

  9. Analysis of cohesion and collective efficacy profiles for the performance of soccer players.

    Science.gov (United States)

    Leo, Francisco M; Sánchez-Miguel, Pedro A; Sánchez-Oliva, David; Amado, Diana; García-Calvo, Tomás

    2013-12-18

    The principal aims of the study were to define different profiles of cohesion and perceived efficacy in soccer players and to measure their differences in performance. The subjects were 235 soccer players in the under-18 category who played in the National League in Spain and 15 coaches whose ages ranged from 29 to 45 years. Diverse instruments to assess cohesion, perceived efficacy, and expectations of success were used in the study. Moreover, we measured playing time and performance. The results of the study proved the existence of four cohesion and efficacy profiles that presented significant differences in expectations of success, playing time, and performance. Furthermore, significant differences were found in the distribution of players in the teams as a function of performance. The main conclusion of this study is that soccer players with higher cohesion and collective efficacy levels belonged to teams that completed the season at the top-level classification. In contrast, athletes with low cohesion and collective efficacy usually played in unsuccessful teams. Coaches and sports psychologists are encouraged to promote both social and task cohesion and collective efficacy to enhance team performance.

  10. Effect of Age Group on Technical-Tactical Performance Profile of the Serve in Men's Volleyball.

    Science.gov (United States)

    García-de-Alcaraz, Antonio; Ortega, Enrique; Palao, José M

    2016-10-01

    The aim of this study was to analyze the technical-tactical performance profile of the serve for various age groups and categories of competition in men's volleyball. The sample comprised 13,262 serves performed by 986 players in 299 sets observed in various categories of competition (U-14, U-16, U-19, national senior, and international senior). An observational design was used. The variables studied were category of competition, type of execution, and serve performance. The results showed that for higher age groups (senior categories), there were significantly fewer jump serves and poorer serve performance, regardless of players' maturity and training development. The use of the jump serves increased the serve risk while attempting to hinder the organization of the opponent attack. This paper discusses the serve evolution and the implications on the training process at the different age groups in men's volleyball. © The Author(s) 2016.

  11. Leadership development study :success profile competencies and high-performing leaders at Sandia National Laboratories.

    Energy Technology Data Exchange (ETDEWEB)

    Becker, Katherine M.; Mulligan, Deborah Rae; Szenasi, Gail L.; Crowder, Stephen Vernon

    2005-04-01

    Sandia is undergoing tremendous change. Sandia's executive management recognized the need for leadership development. About ten years ago the Business, Leadership, and Management Development department in partnership with executive management developed and implemented the organizational leadership Success Profile Competencies to help address some of the changes on the horizon such as workforce losses and lack of a skill set in the area of interpersonal skills. This study addresses the need for the Business, Leadership, and Management Development department to provide statistically sound data in two areas. One is to demonstrate that the organizational 360-degree success profile assessment tool has made a difference for leaders. A second area is to demonstrate the presence of high performing leaders at the Labs. The study utilized two tools to address these two areas. Study participants were made up of individuals who have solid data on Sandia's 360-degree success profile assessment tool. The second assessment tool was comprised of those leaders who participated in the Lockheed Martin Corporation Employee Preferences Survey. Statistical data supports the connection between leader indicators and the 360-degree assessment tool. The study also indicates the presence of high performing leaders at Sandia.

  12. Challenges of animal models in SCI research: Effects of pre-injury task-specific training in adult rats before lesion.

    Science.gov (United States)

    May, Zacnicte; Fouad, Karim; Shum-Siu, Alice; Magnuson, David S K

    2015-09-15

    A rarely explored subject in animal research is the effect of pre-injury variables on behavioral outcome post-SCI. Low reporting of such variables may underlie some discrepancies in findings between laboratories. Particularly, intensive task-specific training before a SCI might be important, considering that sports injuries are one of the leading causes of SCI. Thus, individuals with SCI often underwent rigorous training before their injuries. In the present study, we asked whether training before SCI on a grasping task or a swimming task would influence motor recovery in rats. Swim pre-training impaired recovery of swimming 2 and 4 weeks post-injury. This result fits with the idea of motor learning interference, which posits that learning something new may disrupt learning of a new task; in this case, learning strategies to compensate for functional loss after SCI. In contrast to swimming, grasp pre-training did not influence grasping ability after SCI at any time point. However, grasp pre-trained rats attempted to grasp more times than untrained rats in the first 4 weeks post-injury. Also, lesion volume of grasp pre-trained rats was greater than that of untrained rats, a finding which may be related to stress or activity. The increased participation in rehabilitative training of the pre-trained rats in the early weeks post-injury may have potentiated spontaneous plasticity in the spinal cord and counteracted the deleterious effect of interference and bigger lesions. Thus, our findings suggest that pre-training plays a significant role in recovery after CNS damage and needs to be carefully controlled for.

  13. Effects of Pre-Injury Anti-Platelet Agents on Short-Term Outcome of Patients with Mild Traumatic Brain Injury: A Cohort Study

    Directory of Open Access Journals (Sweden)

    Davood Farsi

    2017-04-01

    Full Text Available Objective: To determine the effects of pre-injury consumption of anti-platelet agents on the 30-day outcomes of patients with mild traumatic brain injury (TBI. Methods: This prospective cohort study was conducted at three general hospitals in Tehran, Iran between July 2013 and July 2014. The study population included all patients with mild TBI aged over 18 years that medicated with aspirin or clopidogrel before occurring trauma. Within hospitalization, all patients were assessed with respect to in-hospital conditions especially complications and adverse events. After discharge, the individuals were followed for 30 days by telephone to assess mortality and disability using the Glasgow outcome scale (GOS. Results: Of 1140 patients with mild TBI, only 135 had previously received aspirin and/or clopidogrel. The mean age was dramatically higher in those who were taking aspirin or clopidogrel (p<0.001. The patients with previously use of anti-platelets were more transferred by ambulance when compared to another group (p=0.006. The patients on anti-platelets had significantly lower GCS on admission when compared to others (p<0.001. Length of hospitalization was significantly longer in those receiving anti-platelets (p=0.003. In follow-up, 30-day mortality and disability was revealed in 2.8% of patients that received only aspirin and 7.5% in aspirin with clopidogrel and in 1.6 % of those who did not receive drugs without any significant difference between aspirin and control group (p=0.208 and significant difference in aspirin with clopidogrel group (p<0.001. Conclusion: The premedication by anti-platelets (aspirin and/or clopidogrel in patients with mild TBI leads to prolonged hospital stay, and increase rate of disability. Age and on admission GCS are the independent risk factors for predicting the outcome in patients with mild TBI receiving anti-platelet agents.

  14. Intensity profile during an ultra-endurance triathlon in relation to testing and performance.

    Science.gov (United States)

    Barrero, A; Chaverri, D; Erola, P; Iglesias, X; Rodríguez, F A

    2014-12-01

    We examined the heart rate (HR)-based intensity profile during an ultra-endurance triathlon (UET) estimated from the individual HR-oxygen uptake (˙VO2) relationship during specific graded tests, relating it to race performance. 9 male ultra-endurance triathletes completed the study. Before racing, subjects performed graded exercise tests involving cycle (C) ergometry, treadmill running (R) and free swimming (S) for peak ˙VO2 and HR at ventilatory thresholds (VT). Exercise-specific HR-˙VO2 regression equations were developed. Mean race HR was higher during S (149.2 (10.1) bpm) than during C (137.1 (5.7) bpm) and R (136.2 (10.5) bpm). During C and R, HR was below both VT (11% and 27-28%). HR differences between S and C correlated with C, R and final times. The greatest differences between S and C were related to the worst times in the next stages. These ultra-endurance triathletes performed S at a higher relative intensity, which was inversely correlated with performance in the following stages. The best predictors of final racing time (81%) were weight-adjusted ˙VO2max and HR difference between C and S. A more adequate characterization of the time pattern during the whole race, especially during S, adds new information concerning the intensity profile and cardiovascular demands of an UET race.

  15. Calculation of the non-inductive current profile in high-performance NSTX plasmas

    Science.gov (United States)

    Gerhardt, S. P.; Fredrickson, E.; Gates, D.; Kaye, S.; Menard, J.; Bell, M. G.; Bell, R. E.; Le Blanc, B. P.; Kugel, H.; Sabbagh, S. A.; Yuh, H.

    2011-03-01

    The constituents of the current profile have been computed for a wide range of high-performance plasmas in NSTX (Ono et al 2000 Nucl. Fusion 40 557); these include cases designed to maximize the non-inductive fraction, pulse length, toroidal-β or stored energy. In the absence of low-frequency MHD activity, good agreement is found between the reconstructed current profile and that predicted by summing the independently calculated inductive, pressure-driven and neutral beam currents, without the need to invoke any anomalous beam ion diffusion. Exceptions occur, for instance, when there are toroidal Alfvén eigenmode avalanches or coupled m/n = 1/1 + 2/1 kink-tearing modes. In these cases, the addition of a spatially and temporally dependent fast-ion diffusivity can reduce the core beam current drive, restoring agreement between the reconstructed profile and the summed constituents, as well as bringing better agreement between the simulated and measured neutron emission rate. An upper bound on the fast-ion diffusivity of ~0.5-1 m2 s-1 is found in 'MHD-free' discharges, based on the neutron emission, the time rate of change in the neutron signal when a neutral beam is stepped and reconstructed on-axis current density.

  16. The Colorado Individual Performance Profile for Hearing-Impaired Students: A Data-Driven Approach to Decision Making.

    Science.gov (United States)

    Yoshinaga-Itano, Christine; Ruberry, Joan

    1992-01-01

    The Colorado Individual Performance Profile for Hearing-Impaired Students is presented as a tool for providing objective criteria for determining appropriate levels of educational services. The profile rates each student's audiological acuity, communication, English language skills, social-emotional development, life skills, cognition, and other…

  17. Effect of selenium supplementation on performance, cost economics, and biochemical profile of Nellore ram lambs.

    Science.gov (United States)

    Sushma, K; Reddy, Y Ramana; Kumari, N Nalini; Reddy, P Baswa; Raghunandan, T; Sridhar, K

    2015-09-01

    Present experiment was conducted to investigate the effect of selenium (Se) supplementation on performance, carcass characteristics, meat composition, shelflife of meat and biochemical profile in Nellore ram lambs. 24 male Nellore ram lambs (15.75±0.47 kg) were randomly divided into four dietary groups with six lambs in each and reared under uniform management conditions for 120 days. Basal diet was not supplemented with Se and consisted of green fodder (Se 0.09 mg/kg dry matter [DM]), dry roughage (Se 0.11 mg/kg DM) and concentrate mixture (Se 0.019 mg/kg DM) and fed individually. Dietary treatments were prepared by adding graded levels Se (0, 0.45, 0.9, and 1.8 ppm) to concentrate mixture (1% body weight [BW]) from sodium selenite. Feed offered and refusal measured daily; and BWs were measured at fortnight interval to find out average daily gain (g), feed conversion ratio (FCR), cost economics and plane of nutrition. Serum biochemical profile (concentration of glucose, total protein, albumin, globulin, cholesterol, and hemoglobin) was assessed on 0, 60(th), and 120(th) day. At the end of experiment, the carcass characteristics (dressing percentage, cut-up parts, meat to bone ratio) and meat chemical composition were evaluated. Meat keeping (thiobarbituric acid reactive substances) quality from different groups was evaluated on day 0, 3, and 6 post-slaughter. Dietary Se supplementation did not show any effect on weight gain, FCR, cost economics, plane of nutrition, and serum biochemical profile in Nellore ram lambs. However, Se supplemented lambs had numerically higher weight gain than the unsupplemented lambs. Similarly, carcass characteristics and keeping quality were comparable among the four treatments. However, numerical increase in post-slaughter keeping quality with increasing Se supplementation was observed. It can be concluded that supplementation of Se in the form of sodium selenite (inorganic source) at different levels did not influence animal

  18. Impact of Diet Containing Grape Pomace on Growth Performance and Blood Lipid Profile of Young Rats.

    Science.gov (United States)

    Smith, Ivy; Yu, Jianmei; Hurley, Steven L; Hanner, Tracy

    2017-06-01

    Grape pomace (GP), the residue of grapes after wine making, is rich in dietary polyphenols and fiber, and it has potential to serve as a functional food ingredient to improve health. However, high polyphenol diets have also been reported to inhibit the growth of young animals and cause liver necrosis. This study investigated the effect of diets containing different amounts of GP on the growth performance and blood lipid profile by using a young rat model. Twenty female Sprague-Dawley rats of age 7 weeks were randomly divided into four groups that were fed AIN-93G diets that were modified by substituting 0%, 10%, 20%, and 30% of carbohydrate with GP for 10 weeks (the diets, thus, obtained contained 0%, 6.9%, 13.8%, and 20.7% of GP). The group fed original AIN-93G (0% GP) was used as control. Feed consumption, body weight, length, and height were recorded weekly. Blood samples were taken biweekly to analyze plasma lipid profile. At the end of the feeding period, the rats were fasted overnight and euthanized by exsanguination under anesthesia. Livers, hearts, and kidneys were collected, and their weights were recorded. Results show that the diet containing a maximum of 20.7% of GP did not influence the body weights, lengths, and heights of rats. As the GP content increased, the blood triglyceride and very low-density lipoproteins (VLDL) decreased, the high-density lipoprotein (HDL) and low-density lipoprotein (LDL) increased slightly but were statistically significant, and total cholesterol remained constant. In conclusion, GP in the AIN-93G diet did not influence the growth performance of young rats, but it exhibited both positive and negative effects on the blood lipid profile.

  19. Perprof-py: A Python Package for Performance Profile of Mathematical Optimization Software

    Directory of Open Access Journals (Sweden)

    Abel Soares Siqueira

    2016-04-01

    Full Text Available A very important area of research in the field of Mathematical Optimization is the benchmarking of optimization packages to compare solvers. During benchmarking, one usually collects a large amount of information like CPU time, number of functions evaluations, number of iterations, and much more. This information, if presented as tables, can be difficult to analyze and compare due to large amount of data. Therefore tools to better process and understand optimization benchmark data have been developed. One of the most widespread tools is the Performance Profile graphics proposed by Dolan and Moré [2]. In this context, this paper describes perprof-py, a free/open source software that creates 'Performance Profile' graphics. This software produces graphics in PDF using LaTeX with PGF/TikZ [22] and PGFPLOTS [4] packages, in PNG using matplotlib [9], and in HTML using Bokeh [1]. Perprof-py can also be easily extended to be used with other plot libraries. It is implemented in Python 3 with support for internationalization, and is under the General Public License Version 3 (GPLv3.

  20. The 10-20-30 training concept improves performance and health profile in moderately trained runners

    DEFF Research Database (Denmark)

    Gunnarsson, Thomas Gunnar Petursson; Bangsbo, Jens

    2012-01-01

    The effect of an alteration from regular endurance to interval (10-20-30) training on the health profile, muscular adaptations, maximum oxygen uptake (VO(2)-max) and performance of runners was examined. Eighteen moderately trained individuals (6 females and 12 males; VO(2)-max: 52.2±1.5 ml(.)kg(-1......% of maximal intensity] for 30, 20 and 10 s, respectively, in 3-4 5-min intervals interspersed by 2 min of recovery, reducing training volume by 54% (14±0.9 vs. 30.4±2.3 km(.)week(-1)) while CON continued the normal training. After the intervention period VO(2)-max in 10-20-30 was 4% higher, and performance...

  1. Interpersonal value profiles and analysis of adolescent academic performance and social thought

    Directory of Open Access Journals (Sweden)

    José Jesús eGázquez

    2015-05-01

    Full Text Available The purposes of this study were to identify interpersonal value profiles and find out whether there were any differences in academic performance and social thinking. The study sample was 885 high school students of whom 49.8% (N=441 were boys and 50.2% (N=444 were girls. The results show that students with low Benevolence and Conformity levels showed higher prevalence of failures and repeated the year more often. Furthermore, students with a high level of Recognition and Leadership and low Conformity and Benevolence are socially incompetent students. Intervention programs should to achieve high levels of kindness and consideration, respect for rules and generosity, and diminish the perception of recognition by others and exertion of authority. Thus, this study shows the values that must be worked on to improve students’ Academic Performance and social competence.

  2. Construction Waste Management Profiles, Practices, and Performance: A Cross-Jurisdictional Analysis in Four Countries

    Directory of Open Access Journals (Sweden)

    Vivian Wing-Yan Tam

    2016-02-01

    Full Text Available Construction waste management (CWM has received worldwide attention for some time. As a result, a plethora of research, investigating a wide array of CWM issues such as their profiles, practices, and performance, has been reported in individual economies around the globe. However, a cross-jurisdictional comparison of these issues is limitedly presented in the literature despite its importance to benchmarking performance and identifying best CWM practices in the context of globalization whereby knowledge sharing has already transcended traditional country boundaries. The aim of this ex post facto research is to compare CWM profiles, practices, and performance in Australia, Europe (Europe refers to EU-27 member countries in the European Union, including Belgium, France, Germany, Italy, Luxembourg, Netherlands, Denmark, Great Britain, Ireland, Portugal, Spain, Greece, Austria, Finland, Sweden, Czech Republic, Estonia, Hungary, Latvia, Lithuania, Poland, Slovakia, Slovenia, Malta, Cyprus, Bulgaria, and Romania., Hong Kong, and the United Kingdom at a national-level, with a view to facilitating CWM knowledge sharing internationally. It does so by triangulating empirical data collected from various national statistical yearbooks with research papers and professional reports on CWM in these economies. It is found that in producing one million (US dollars’ work, construction contributes a volume of solid waste ranging from 28 to 121 tons among countries. Conscientious CWM practices can make a significant difference in reducing, reusing, or recycling construction waste, as evident in the large variation in the CWM performance. While it might be oversimplified to conclude that the best practices in one country can be applied in another, the research provides insightful references into sharing CWM knowledge across boundaries.

  3. Morphological, Physiological and Skating Performance Profiles of Male Age-Group Elite Ice Hockey Players

    Directory of Open Access Journals (Sweden)

    Allisse Maxime

    2017-08-01

    Full Text Available The purpose of this study was to describe the evolution of morphological, physiological and skating performance profiles of elite age-group ice hockey players based on repeated measures spread over one season. In addition, the results of fitness tests and training programs performed in off-ice conditions and their relationship with skating performance were analyzed. Eighteen high level age-group ice hockey players (13.1 ± 0.6 years were assessed off and on-ice at the beginning and at the end of the hockey season. A third evaluation was also conducted at the beginning of the following hockey season. The players were taller, heavier, and showed bone breadths and muscle girths above the reference population of the same age. Muscular variables improved significantly during and between the two hockey seasons (p < 0.05. However, maximal aerobic power improved only during the off-season. All skating performance tests exhibited significant enhancements during the hockey season, but not during the off-season where some degradation was observed. Finally, weak observed variances (generally <20% of the explained variance between physiological variables measured off-ice and on-ice skating performance tests indicated important gaps, both in the choice of the off-ice assessment tools as well as in training methods conventionally used. The reflection on the best way to assess and train hockey players certainly deserves to be continued.

  4. Identifying student profiles and their impact on academic performance in a Brazilian undergraduate student sample.

    Science.gov (United States)

    da Silva, E T; de Fátima Nunes, M; Santos, L B; Queiroz, M G; Leles, C R

    2012-02-01

    The recognition of the student profile provides strategic information for planning educational policies in the university environment. The aims of this study were to identify natural segmentation of freshman undergraduate dental students based on demographic, socioeconomic and educational variables, and to subsequently investigate their impact on academic performance of Brazilian undergraduate students. Cluster analysis (two-step algorithm) was used to segment students who entered dental school in the time period from 1999 to 2001 (n=158) into groups based on responses to a questionnaire completed by students at the time of the admission examination. Clustering analysis revealed three natural groups. Age, the parents' level of education, and performance on the first admission test were the most important variables for cluster segmentation. Cluster 1 (n=42; 26.6%) was characterized by female students with higher socioeconomic status and better previous educational indicators. Cluster 2 (n=62; 39.2%) represented disadvantaged socioeconomic profiles, with a predominance of females and older students. Cluster 3 (n=54; 34.2%) showed similar socioeconomic characteristics to cluster 1, except for male prevalence, higher age, and experiencing difficulty in the admission test. Clusters' academic performance was satisfactory in both overall course and course groups (grade point average of at least 7.0), with average ranging from 7.89 (SD=0.44) to 8.13 (SD=0.31) and 7.37 (SD=0.75) to 8.31(SD=0.26), respectively. Our findings provide encouraging evidence for the current context of equality of access to education and reveal the importance of financial support to maximize successful educational experiences of socioeconomically disadvantaged dental students.

  5. Aerodynamic performance of NACA four-digit profiles in small-scale wind turbines for small farms

    Directory of Open Access Journals (Sweden)

    Paulo Alexandre Costa Rocha

    2015-06-01

    Full Text Available In Brazil, there are many places that do not have access to electric energy, mainly in rural areas with small farms. This situation has accentuated the importance of renewable energy sources, such as wind energy. This work consisted of the design, construction and field testing of two small three-bladed wind turbines with two different aerodynamic profiles. The aim of the study was to compare the profile influence on the turbine aerodynamic performance. Using the blade element momentum (BEM theory, two wind turbines were designed and built with different cross-section aerodynamic profiles (NACA 0012 (symmetric and 4412 (chambered. Following statistical analysis, the results of the field tests demonstrated that the performances of the turbines are similar when the rotational speed is near the designed value (?=5. However, when the rotational speed is under or above the designed value, the NACA 4412 profile yields superior performance

  6. Integrated Microfluidic Lectin Barcode Platform for High-Performance Focused Glycomic Profiling.

    Science.gov (United States)

    Shang, Yuqin; Zeng, Yun; Zeng, Yong

    2016-02-02

    Protein glycosylation is one of the key processes that play essential roles in biological functions and dysfunctions. However, progress in glycomics has considerably lagged behind genomics and proteomics, due in part to the enormous challenges in analysis of glycans. Here we present a new integrated and automated microfluidic lectin barcode platform to substantially improve the performance of lectin array for focused glycomic profiling. The chip design and flow control were optimized to promote the lectin-glycan binding kinetics and speed of lectin microarray. Moreover, we established an on-chip lectin assay which employs a very simple blocking method to effectively suppress the undesired background due to lectin binding of antibodies. Using this technology, we demonstrated focused differential profiling of tissue-specific glycosylation changes of a biomarker, CA125 protein purified from ovarian cancer cell line and different tissues from ovarian cancer patients in a fast, reproducible, and high-throughput fashion. Highly sensitive CA125 detection was also demonstrated with a detection limit much lower than the clinical cutoff value for cancer diagnosis. This microfluidic platform holds the potential to integrate with sample preparation functions to construct a fully integrated "sample-to-answer" microsystem for focused differential glycomic analysis. Thus, our technology should present a powerful tool in support of rapid advance in glycobiology and glyco-biomarker development.

  7. Motivational profiles of slovenian high school students and their academic performance outcomes.

    Science.gov (United States)

    Vrtačnik, Margareta; Juriševič, Mojca; Savec, Vesna Ferk

    2010-09-01

    Self-determination theory defines motivation as a multidimensional concept, with autonomous and controlled motivation as central factors of broader distinctions. Previous research has proven that academic achievements are positively correlated with autonomous motivation. Students from 10 Slovenian grammar schools were involved in empirical study, in which a cluster analysis revealed two motivational profiles: a low quantity motivation group (low controlled and autonomous motivation) and a good quality motivation group (high autonomous and low or average controlled motivation). Statistically significant differences between the two identified motivational profiles were found for students' general as well as chemistry performance in three grades of schooling. Furthermore, a good quality motivation group is also more in favour of autonomy-supportive teaching methods used in chemistry classes. Examination of students' opinions about important chemistry topics, and on the other hand, unimportant ones, and not connected with life, reveals that the basic reason for distinction might lie in the chemistry teacher's approach used while presenting these topics. Some chemistry teachers are not using an autonomy-supportive way of teaching which would contribute to better teaching outcomes; therefore a need for further research on Slovenian chemistry teachers' motivation and their teaching approaches was recognized.

  8. Effect of Dietary Inulin Source on Piglet Performance, Immunoglobulin Concentration, and Plasma Lipid Profile

    Directory of Open Access Journals (Sweden)

    Grela Eugeniusz R.

    2014-10-01

    Full Text Available The aim of the study was to evaluate the effect of an inulin source (aqueous or aqueous-alcoholic extract, dried chicory root, or dried Jerusalem artichoke tubers on piglet performance, plasma lipid profile, and immunoglobulin concentration. The study was conducted on 534 piglets (44 litters allocated to five nutritional groups: group I (control - fed basal diet, groups II and III receiving basal diet supplemented with 2% of inulin (aqueous and aqueous-alcoholic extract respectively, and groups IV and V -4% additive of dried artichoke or dried chicory respectively. During the trial, piglets’ body weight, feed intake, diarrhoea incidence, and mortality were controlled. Blood samples were collected twice from six animals of each group. In blood plasma, indices of lipid profile and concentrations of IgA, IgG and IgM were measured. The addition of inulin, regardless of its form (extracts or dried plants, significantly improved the rearing indices. In piglets of groups III, IV and V a significant improvement of daily weight gains and feed efficiency was noted. Inulin showed hypolipidemic activity (lowered total cholesterol level and stimulated piglet immune system manifested by elevated IgA and IgG concentrations. Irrespective of the inulin source, a lower mortality rate resulting from the improvement of animal health was noted in all experimental groups.

  9. Somatic, Endurance Performance and Heart Rate Variability Profiles of Professional Soccer Players Grouped According to Age

    Directory of Open Access Journals (Sweden)

    Botek Michal

    2016-12-01

    Full Text Available This cross-sectional study compared somatic, endurance performance determinants and heart rate variability (HRV profiles of professional soccer players divided into different age groups: GI (17–19.9 years; n = 23, GII (20–24.9 years; n = 45, GIII (25–29.9 years; n = 30, and GIV (30–39 years; n = 26. Players underwent somatic and HRV assessment and maximal exercise testing. HRV was analyzed by spectral analysis of HRV, and high (HF and low (LF frequency power was transformed by a natural logarithm (Ln. Players in GIV (83 ± 7 kg were heavier (p 25 years showed negligible differences in Pmax unlike the age group differences demonstrated in VO2max. A shift towards relative sympathetic dominance, particularly due to reduced vagal activity, was apparent after approximately 8 years of competing at the professional level.

  10. Full deflection profile calculation and Young’s modulus optimisation for engineered high performance materials

    Science.gov (United States)

    Farsi, A.; Pullen, A. D.; Latham, J. P.; Bowen, J.; Carlsson, M.; Stitt, E. H.; Marigo, M.

    2017-04-01

    New engineered materials have critical applications in different fields in medicine, engineering and technology but their enhanced mechanical performances are significantly affected by the microstructural design and the sintering process used in their manufacture. This work introduces (i) a methodology for the calculation of the full deflection profile from video recordings of bending tests, (ii) an optimisation algorithm for the characterisation of Young’s modulus, (iii) a quantification of the effects of optical distortions and (iv) a comparison with other standard tests. The results presented in this paper show the capabilities of this procedure to evaluate the Young’s modulus of highly stiff materials with greater accuracy than previously possible with bending tests, by employing all the available information from the video recording of the tests. This methodology extends to this class of materials the possibility to evaluate both the elastic modulus and the tensile strength with a single mechanical test, without the need for other experimental tools.

  11. The Distribution Network Reconfiguration Improved Performance of Genetic Algorithm Considering Power Losses and Voltage Profile

    Directory of Open Access Journals (Sweden)

    N. H. Shamsudin

    2014-05-01

    Full Text Available Power losses issues persevered over few decades in the high demand utilization of energy electricity in developing countries. Thus, the radial structure of distribution network configuration is extensively used in high populated areas to ensure continuity of power supply in the event of fault. This paper proposes heuristic Genetic Algorithm known as SIGA (Selection Improvement in Genetic Algorithm in consideration of genetic operator probabilities likewise the progression of switch adjustment in Distribution Network Reconfiguration (DNR while satisfying the parameters constraints. The SIGA algorithm was embodied throughout the process in IEEE 33-bus distribution system in selection of five tie switches. As a consequence, the power losses were ranked in accordance to the minimum values and voltage profile improvement obtainable by the proposed algorithm. The results show that the SIGA performs better than GA by giving the minimized value of power losses.

  12. SOCIO -DEMOGRAPHY, PERSONALITY PROFILE AND ACADEMIC PERFORMANCE OF VARIOUS CATEGORIES OF MEDICAL STUDENTS

    Science.gov (United States)

    Jiloha, R.C.; Kishore, Jugal

    1998-01-01

    To compare the Scheduled Caste (SC) & Scheduled Tribe (ST) students with general students regarding their school and family background, personality profile and personal problems, a stratified systematic sample of 261 medical students was taken who filled up their individual set of questionnaires consisting of semistructured sociodemographic proforma, Personality Trait Inventory (PTI) and Students Personal Problems Index. Statistically significant differences were observed when schooling, family income, parents education and occupation and academic performance of general, SC and ST students were compared. Although no statistical differences on personality trait were observed, on activity and cyclothymic personality trait SC and ST students scored less, whereas, they scored more on depressive tendency, emotional instability and social desirability personality traits. The personal problems were different in three groups and also the number of attempts made to pass their professional examinations. Intervention measures have been suggested. PMID:21494478

  13. Effects on cognitive performance of modulating the postprandial blood glucose profile at breakfast.

    Science.gov (United States)

    Nilsson, A; Radeborg, K; Björck, I

    2012-09-01

    Considering the importance of glucose as a brain substrate, the postprandial rate of glucose delivery to the blood could be expected to affect cognitive functions. The purpose was to evaluate to what extent the rate of glucose absorption affected measures of cognitive performance in the postprandial period. In addition, cognitive performance was evaluated in relation to individual glucoregulation. A white wheat bread (WWB) enriched with guar gum (G-WWB) with the capacity to produce a low but sustained blood glucose net increment was developed. The G-WWB was evaluated in the postprandial period after breakfast with respect to effects on cognitive function (working memory and selective attention (SA)) in 40 healthy adults (49-71 years, body mass index 20-29 kg/m(2)), using a high glycaemic index WWB for comparison in a randomised crossover design. The G-WWB improved outcome in the cognitive tests (SA test) in the later postprandial period (75-225 min) in comparison with the WWB (Pcognitive tests compared with subjects with worse glucoregulation (Pcognitive performance were observed with the G-WWB in the late postprandial period. The positive effect is suggested to emanate from improved insulin sensitivity, possibly in a combination with an enhanced neural energy supply. The results highlight the importance of carbohydrate foods that induces a low but sustained blood glucose profile in enhancing postprandial cognitive functions.

  14. Coaches, Athletes, and Dominance Profiles in Sport: Addressing the Learning Styles of Athletes to Improve Performance

    Science.gov (United States)

    Stevens, Debbie; Cadorette, Deborah

    2012-01-01

    The purpose of this article is to examine the background and purpose of using dominance profiles to assist coaches in determining learning preferences for themselves and their athletes. Dominance profiles can provide information that will help coaches understand the differences in how athletes think, act, and learn. Dominance profiles can help…

  15. Repeated-sprint performance, locomotor profile and muscle oxygen uptake recovery: effect of training background.

    Science.gov (United States)

    Ufland, P; Ahmaidi, S; Buchheit, M

    2013-10-01

    The aim of the present study was to examine the respective importance of locomotor profile and muscle oxygen uptake (mV(˙)O₂) recovery on repeated-sprint ability (RSA) and overall repeated-sprint performance. 11 sprint- (STR) and 10 middle-distance-trained (MDTR) athletes (20.8±4.0 yr) performed an incremental test and a 40-to-50-m sprint to estimate their maximal aerobic (MAS) and sprinting (MSS) speeds. They also performed 6×30-m sprints, departing every 30 s, where mean (RS(mean)) sprint time was calculated. Muscle oxygenation (Near-infrared spectroscopy, NIRS, [Hb(diff)]) was measured for ~ 4 min post test. The mean response time of [Hb(diff)]-mV(˙)O₂ recovery (monoexponential curve fitting, MRT[Hb(diff)]-mV(˙)O₂) was calculated. Compared with MDTR, STR presented faster MSS (+11.4±6.7%, with 99% chances to observe a substantially greater value) and RS(mean) (-3.7±5.4%, 78%), but slower MAS (-15.8±8.0%, 100%) and MRT[Hb(diff)]-mV(˙)O₂ (+46.2±31.7%, 96%). RS(mean) was largely correlated with MSS [r=-0.83 (90%CL, -0.92;-0.67)], but neither with MAS [r=-0.12 (-0.47;0.25)] nor MRT[Hb(diff)]-mV(˙)O₂ [r=-0.27(-0.58;0.11)]. RS(mean) adjusted for MSS (which indirectly reflects RSA) was largely correlated with both MAS [r=0.51(0.18;0.74)] and MRT[Hb(diff)]-mV(˙)O₂ [r=0.53(0.20;0.75)]. While a fast mV(˙)O₂ recovery is associated with an improved RSA, MSS remains of primary importance for overall repeated-sprint performance (i.e., RS(mean)).

  16. Impact of Cn2 profile on tomographic reconstruction performance: application to E-ELT wide field AO systems

    Science.gov (United States)

    Costille, A.; Fusco, T.

    2012-07-01

    New techniques of Adaptive Optics (AO), generically called Wide Field AO, have been developed in the frame of the design study for new instruments for Extremely Large Telescopes (ELI). Concepts such as Multi-Conjugate AO are based on a tomographic reconstruction of the turbulent volume followed by a projection onto DM(s) in order to ensure a good correction in a large Field of View. These systems require a 3D phase reconstruction and a statistical representation of the turbulent volume through the knowledge of the Cn2 profile, which has a strong impact on performance. We focus our study on the analysis of the impact of the structure and the parameters, which define the Cn2 profile, on the performance of a given tomographic system for an ELI. In this article, we perform simulation to emphasize the terms which are directly linked to the knowledge of the true input Cn2 profile, which simulates the input turbulent perturbations, and to the Cn2 profile which is used as a model in the reconstruction process. We determine and discuss the level of the accuracy needed on the Cn2 profile to limit the tomographic error term and to ensure a good performance. We show that a good sampling of the input turbulence is required to ensure performance of the system.

  17. Sensory profile of first grade students: analysis and comparison with school performance

    Directory of Open Access Journals (Sweden)

    Fernanda de Burgos Rocha

    2013-08-01

    Full Text Available Introduction: Children must adequately perceive their environment before they can actually develop and manipulate it. Human beings perceive their environment through their senses. To manipulate this environment, we must capture information through our sense organs and decode, process, integrate and interpret the pieces of information, so that we can act adequately in our environment. Difficulties to process or interpret sensory information will result in learning impairment. Objective: To compare the Sensory Profile results with the scores of first grade students aged between 6 and 8 years old; to observe the relation between sensory processing quality and school performance. Methods: This is a descriptive cross-sectional study. Results: Results indicate high incidence of sensory problems that interfere in the quality of muscular tonus and body posture. Visual information presented the highest processing quality, while vestibular and oral information presented the lowest processing quality. Finally, it was possible to observe that children who present sensory processing at Typical Performance and Probable Difference scores tend to present the best academic achievement. Conclusion: Sensory processing interferes in academic achievement, but this is not the only factor that predicts good school scores. The highest number of changes presented is related to vestibular information.

  18. Profile of the appendectomies performed in the Brazilian Public Health System

    Directory of Open Access Journals (Sweden)

    FERNANDA DOS SANTOS

    Full Text Available ABSTRACT Objective: to analyze the profile of appendectomies performed in the Brazilian Public Health System (SUS and to compare the laparoscopic and laparotomic techniques of appendectomy. Methods: This work used information from DataSus from 2008 to 2014 (http://datasus.saude.gov.br. We compared the data of patients submitted to laparotomic appendectomy with those submitted to laparoscopic one. Results: when comparing the total growth of appendectomies, the laparoscopic route increased 279.7%, while the increase in laparotomic surgery was 25% (p <0.001 in the study period. With regard to medical and hospital costs, laparoscopic appendectomy accounted for only 2.6% of the total expenditure on appendectomies performed by the Unified Health System (SUS hospitals, with an average cost 7.6% lower than that of laparotomy procedures, but without statistical significance. The mortality rate was 57.1% lower in the laparoscopic approach when compared with laparotomy. Conclusion: there has been a significant increase in the laparoscopic route in the treatment of appendicitis, but the method is still rarely used in SUS patients. The costs of laparoscopic appendectomy were similar to those observed in laparotomic access.

  19. Work process, performance and professional profile of a Hearing Health Network: reference for satisfaction.

    Science.gov (United States)

    Escarce, Andrezza Gonzalez; Lemos, Stela Maris Aguiar; Carvalho, Sirley Alves da Silva

    2016-01-01

    To analyze the correlation between the satisfaction of professionals from the Hearing Health Care network in two micro-regions of Minas Gerais state and the sociodemographic profile, work process, and work performance in the health service. This is a cross-sectional, observational, analytic study with a non-probabilistic sample including 34 professionals from the Hearing Health Care services. Data collection occurred through individual interviews in the municipality of professional practice. Associations between the Professional Satisfaction variable and the explanatory variables Sociodemographic Data, Work Routine, and Developed Actions were conducted. Professionals with graduate studies were more satisfied with the human resources policy and the activities developed, whereas health civil servants showed more satisfaction with the wage policy and the work schedule. The correlation analysis between work process and satisfaction revealed a moderate positive correlation between items such as Health Promotion Actions, Satisfaction with Diagnostic Equipment, and Satisfaction with Maintenance Equipment. The present study revealed a higher level of satisfaction among professionals with graduate studies (human resources policy and activities developed) and civil servants (wage policy and work schedule). The relevance of this study lies on the important role that health professionals play on the Health Care Network. Additionally, the study of satisfaction level can provide a search for improvements, considering that satisfied professionals not only improve service quality, but also show greater creativity, commitment, and performance.

  20. Effects of Supplemental Exogenous Emulsifier on Performance, Nutrient Metabolism, and Serum Lipid Profile in Broiler Chickens

    Directory of Open Access Journals (Sweden)

    Amitava Roy

    2010-01-01

    Full Text Available The effects of an exogenous emulsifier, glyceryl polyethylene glycol ricinoleate, on performance and carcass traits of broiler chickens were assessed. The emulsifier was added to the diet at dose rates of 0 (control, 1 (E1 and 2 (E2 % of added fat (saturated palm oil. Live weight gain (<.07 and feed conversion ratio (<.05 in 39 days were higher in the E1 dietary group. Gain: ME intake and gain: protein intake during the grower phase improved quadratically (<.05. Gross carcass traits were not affected. Body fat content and fat accretion increased (<.05 and liver fat content decreased (<.05 linearly with the level of emulsifier in diet. Fat excretion decreased (<.001 leading to increased ileal fat digestibility (<.06 in the E1 group (quadratic response. Metabolizable intake of N (<.1 and fat (<.05 increased quadratically due to supplementation of emulsifier in diet. Metabolism of trace elements and serum lipid profiles were not affected. The study revealed that supplementation of exogenous emulsifiers in diets containing moderate quantities of added vegetable fats may substantially improve broiler performance.

  1. Sake Protein Supplementation Affects Exercise Performance and Biochemical Profiles in Power-Exercise-Trained Mice

    Directory of Open Access Journals (Sweden)

    Yi-Ming Chen

    2016-02-01

    Full Text Available Exercise and fitness training programs have attracted the public’s attention in recent years. Sports nutrition supplementation is an important issue in the global sports market. Purpose: In this study, we designed a power exercise training (PET program with a mouse model based on a strength and conditional training protocol for humans. We tested the effect of supplementation with functional branched-chain amino acid (BCAA-rich sake protein (SP to determine whether the supplement had a synergistic effect during PET and enhanced athletic performance and resistance to fatigue. Methods: Male ICR mice were divided into three groups (n = 8 per group for four-week treatment: sedentary controls with vehicle (SC, and PET and PET groups with SP supplementation (3.8 g/kg, PET + SP. Exercise performance was evaluated by forelimb grip strength and exhaustive swimming time as well as changes in body composition and anti-fatigue activity levels of serum lactate, ammonia, glucose, and creatine kinase (CK after a 15-min swimming exercise. The biochemical parameters were measured at the end of the experiment. Results: four-week PET significantly increased grip strength and exhaustive swimming time and decreased epididymal fat pad (EFP weight and area. Levels of aspartate aminotransferase (AST, alanine aminotransferase (ALT, creatinine, and uric acid (UA were significantly increased. PET + SP supplementation significantly decreased serum lactate, ammonia and CK levels after the 15-min swimming exercise. The resting serum levels of AST, ALT, CREA and UA were all significantly decreased with PET + SP. Conclusion: The PET program could increase the exercise performance and modulate the body composition of mice. PET with SP conferred better anti-fatigue activity, improved biochemical profiles, and may be an effective ergogenic aid in strength training.

  2. Implications of fin profiles on overall performance and weight reduction of a fin and tube heat exchanger

    DEFF Research Database (Denmark)

    Singh, Shobhana; Sørensen, Kim; Condra, Thomas Joseph

    2017-01-01

    on a cross-flow type fin and tube heat exchanger design for a waste heat recovery application is conducted. The geometric profile of the fin is characterized by a dimensionless design variable named aspect ratio which is parametrically varied to obtain different profiles. Two cases, case-I, and case......Fin and tube heat exchangers are being used in several industrial applications by means of novel design and optimized performance. Improvements in geometric design may deliver energy efficient and cost-effective heat exchanger performance with reduced weight. In this paper, a systematic study...... design. Results show that the overall performance improves by approximately 6.76% and 17.33% with a reduction in net unit weight by approximately 27.58% and 6.82% on changing the aspect ratio from 1.0 to 0.1 in case-I and case-II, respectively. In addition, feasible fin profile for a waste heat recovery...

  3. Flavonoid profiling of a traditional Chinese medicine formula of Huangqin Tang using high performance liquid chromatography

    Science.gov (United States)

    Li, Tao; Zhuang, Shuaixing; Wang, Yiwei; Wang, Yanli; Wang, Weihao; Zhang, Huihui; Chen, Li; Wang, Dunfang; Zhou, Zhongming; Yang, Weipeng

    2016-01-01

    The quality control processes for herbal medicines have been problematic. Flavonoids are the major active components of Huangqin Tang (HQT, a traditional Chinese medicine formula). In this study, we used a combinative method approach consisting of chromatographic fingerprinting (high performance liquid chromatography; HPLC), quantitative methods and a pharmacodynamic evaluation model to analyze the flavonoids of HQT obtained from different sources. Ten batches of HQT were analyzed by the HPLC fingerprinting method and 26 common peaks were detected, of which 23 peaks corresponded with the chemical profile of HQT. In addition, 11 major compounds were identified by LC–MS analysis (liquid chromatography–tandem mass spectrometer; LC–MSn) and quantified by the HPLC quantitative method approach. The studied 10 batches of HQT were found to be homogeneous in their composition with a similarity between 0.990 and 1.000. The distribution of the 11 identified compounds was found to be very similar among the batches. Only slight pharmacodynamic differences were detected between the different batches, confirming the homogeneity of HQT. The results of this study prove that the combination of chromatographic fingerprinting and quantitative analysis can be readily used for comprehensive quality control of herbal medicines. PMID:27006899

  4. Physical demand profiles of hatha yoga postures performed by older adults.

    Science.gov (United States)

    Salem, George J; Yu, Sean S-Y; Wang, Man-Ying; Samarawickrame, Sachithra; Hashish, Rami; Azen, Stanley P; Greendale, Gail A

    2013-01-01

    Understanding the physical demands placed upon the musculoskeletal system by individual postures may allow experienced instructors and therapists to develop safe and effective yoga programs which reduce undesirable side effects. Thus, we used biomechanical methods to quantify the lower extremity joint angles, joint moments of force, and muscle activities of 21 Hatha yoga postures, commonly used in senior yoga programs. Twenty older adults, 70.7 years ± 3.8 years, participated in a 32-wk yoga class (2 d/wk) where they learned introductory and intermediate postures (asanas). They then performed the asanas in a motion analysis laboratory. Kinematic, kinetic, and electromyographic data was collected over three seconds while the participants held the poses statically. Profiles illustrating the postures and including the biomechanical data were then generated for each asana. Our findings demonstrated that Hatha yoga postures engendered a range of appreciable joint angles, JMOFs, and muscle activities about the ankle, knee, and hip, and that demands associated with some postures and posture modifications were not always intuitive. They also demonstrated that all of the postures elicited appreciable rectus abdominis activity, which was up to 70% of that induced during walking.

  5. Effects of dietary gossypol concentration on growth performance, blood profiles, and hepatic histopathology in meat ducks.

    Science.gov (United States)

    Zeng, Q F; Yang, G L; Liu, G N; Wang, J P; Bai, S P; Ding, X M; Luo, Y H; Zhang, K Y

    2014-08-01

    The objective of this study was to determine the effects of gossypol from cottonseed meal (CSM) on growth performance, blood biochemical profiles, and liver histopathology of ducks. A total of 900 1-d-old ducks were randomly allocated to 5 treatments with 12 pens/treatment and 15 ducks/pen. The 5 experimental diets were formulated in such a way that 0% (a corn-soybean meal basal diet, diet 1), 25% (diet 2), 50% (diet 3), 75% (diet 4), and 100% (diet 5) of protein from soybean meal were replaced with that from CSM. All diets were formulated on a digestible amino acid basis. The experiment included 2 phases, the starter phase (1 to 3 wk) where the test diets contained graded levels of CSM and the growth phase (4 to 5 wk) where birds were fed a corn-soybean basal diet to examine the recovery of ducks after CSM withdrawal. Dietary CSM and gossypol linearly (P ducks among all treatments. These results suggest that meat ducks' dietary TG and FG concentration should be lower than 928.9 and 77.2 mg/kg, respectively, during d 1 to 21 of age and that a 2-wk withdrawal of diets containing gossypol should be considered.

  6. Anthropometric and physical performance profiles of elite karate kumite and kata competitors.

    Science.gov (United States)

    Koropanovski, Nenad; Berjan, Bobana; Bozic, Predrag R; Pazin, Nemanja; Sanader, Aleksandra; Jovanovic, Srecko; Jaric, Slobodan

    2011-12-01

    KARATE TOURNAMENTS CONSIST OF TWO EQUALLY IMPORTANT KARATE DISCIPLINES: the kumite and kata competitions. Due to being based both on the distinctive selection of movement techniques and their kinematic and kinetic patterns, we hypothesized that the elite kumite and kata competitors could differ regarding their anthropometric and physical performance profiles. Thirty-one senior male karate competitors of the national karate team (kumite n = 19; kata n = 12) participated in this study. The tests applied included both the assessment of anthropometric (body height, mass and body mass index) and the following physical performance measurements: the adductor and hamstring flexibility (sideward leg splits test), speed and acceleration (20-m sprint test with 10-m acceleration time), explosive power (countermovement and standing triple jump), agility ("T"- test) and aerobic endurance (20-m multistage shuttle run test). The kumite competitors revealed a larger body size through body height (p = 0.01) and mass (p = 0.03), while the differences in body composition were non-significant. The kumite competitors also demonstrated higher acceleration (p = 0.03) and explosive power (standing triple jump; p = 0.03). A 6-7° higher flexibility of the kata competitors remained somewhat below the level of significance (p = 0.09). The findings could be interpreted by the distinctive differences in the movement techniques. Specifically, a higher explosive power could be beneficial for kumite, while both a smaller stature and higher flexibility (particularly of the lower extremity) could be important for the exceptionally low postures of the kata competitors. Although further elucidation is apparently needed, the obtained finding could be of importance for both the early selection and training of karate competitors.

  7. Physiological, Nutritional and Performance Profiles of Brazilian Jiu-Jitsu Athletes

    Science.gov (United States)

    Santos, Jonatas FS; Esteves, João VDC; Panissa, Valeria LG; Julio, Ursula F; Franchini, Emerson

    2016-01-01

    Abstract This study analysed the physiological, nutritional and performance profiles of athletes practicing Brazilian jiu-jitsu. To this end, 15 athletes that practiced Brazilian jiu-jitsu (aged: 28 ± 5 years; 8 brown belts and 7 black belts; training experience: 11 ± 4 years) underwent anthropometric measurements (body composition and somatotype), dietary evaluation (24 h recall) and physical fitness tests (movement time, dynamometer handgrip, kimono grip strength, vertical jump and sit-and-reach tests). The athletes had 12.7 ± 4.8% of body fat, 59.2 ± 5.0% of muscle mass and their somatotype was dominated by the mesomorphic component (5.3 ± 2.0), followed by endomorphic (3.7 ± 1.5) and ectomorphic (1.4 ± 0.9) components. Nutritional assessment suggested a diet consisting of 54 ± 7% of carbohydrates, 19 ± 4% of protein and 27 ± 6% of lipids. Movement time on the handgrip tests was 0.42 ± 0.05 s, for handgrip strength, 53 ± 7 kgf was found for the dominant hand and 50 ± 9 kgf for the non-dominant hand. For the countermovement jump, the jiu-jitsu athletes reached 41 ± 5 cm. Athletes remained 30 ± 14 s in the maximum static suspension test gripping a kimono, and reached 27 ± 8 cm in the sit-and-reach test. Overall the sample presented average levels of body fat, elevated muscle mass and a predominantly mesomorphic somatotype. Diet was generally poor, with low carbohydrate intake, high protein intake and adequate lipid intake. Maximum isometric handgrip strength was consistent with observations of other athletes in this sport discipline. However, the performance in the maximum static suspension test gripping a kimono was lower than in other Brazilian jiu-jitsu athletes. Movement time was comparable and lower body muscle power was worse compared to athletes in similar sports. Additionally, flexibility was rated as poor. PMID:28149429

  8. Physiological, Nutritional and Performance Profiles of Brazilian Jiu-Jitsu Athletes.

    Science.gov (United States)

    Andreato, Leonardo V; Santos, Jonatas Fs; Esteves, João Vdc; Panissa, Valeria Lg; Julio, Ursula F; Franchini, Emerson

    2016-12-01

    This study analysed the physiological, nutritional and performance profiles of athletes practicing Brazilian jiu-jitsu. To this end, 15 athletes that practiced Brazilian jiu-jitsu (aged: 28 ± 5 years; 8 brown belts and 7 black belts; training experience: 11 ± 4 years) underwent anthropometric measurements (body composition and somatotype), dietary evaluation (24 h recall) and physical fitness tests (movement time, dynamometer handgrip, kimono grip strength, vertical jump and sit-and-reach tests). The athletes had 12.7 ± 4.8% of body fat, 59.2 ± 5.0% of muscle mass and their somatotype was dominated by the mesomorphic component (5.3 ± 2.0), followed by endomorphic (3.7 ± 1.5) and ectomorphic (1.4 ± 0.9) components. Nutritional assessment suggested a diet consisting of 54 ± 7% of carbohydrates, 19 ± 4% of protein and 27 ± 6% of lipids. Movement time on the handgrip tests was 0.42 ± 0.05 s, for handgrip strength, 53 ± 7 kgf was found for the dominant hand and 50 ± 9 kgf for the non-dominant hand. For the countermovement jump, the jiu-jitsu athletes reached 41 ± 5 cm. Athletes remained 30 ± 14 s in the maximum static suspension test gripping a kimono, and reached 27 ± 8 cm in the sit-and-reach test. Overall the sample presented average levels of body fat, elevated muscle mass and a predominantly mesomorphic somatotype. Diet was generally poor, with low carbohydrate intake, high protein intake and adequate lipid intake. Maximum isometric handgrip strength was consistent with observations of other athletes in this sport discipline. However, the performance in the maximum static suspension test gripping a kimono was lower than in other Brazilian jiu-jitsu athletes. Movement time was comparable and lower body muscle power was worse compared to athletes in similar sports. Additionally, flexibility was rated as poor.

  9. Physiological, Nutritional and Performance Profiles of Brazilian Jiu-Jitsu Athletes

    Directory of Open Access Journals (Sweden)

    Andreato Leonardo V

    2016-12-01

    Full Text Available This study analysed the physiological, nutritional and performance profiles of athletes practicing Brazilian jiu-jitsu. To this end, 15 athletes that practiced Brazilian jiu-jitsu (aged: 28 ± 5 years; 8 brown belts and 7 black belts; training experience: 11 ± 4 years underwent anthropometric measurements (body composition and somatotype, dietary evaluation (24 h recall and physical fitness tests (movement time, dynamometer handgrip, kimono grip strength, vertical jump and sit-and-reach tests. The athletes had 12.7 ± 4.8% of body fat, 59.2 ± 5.0% of muscle mass and their somatotype was dominated by the mesomorphic component (5.3 ± 2.0, followed by endomorphic (3.7 ± 1.5 and ectomorphic (1.4 ± 0.9 components. Nutritional assessment suggested a diet consisting of 54 ± 7% of carbohydrates, 19 ± 4% of protein and 27 ± 6% of lipids. Movement time on the handgrip tests was 0.42 ± 0.05 s, for handgrip strength, 53 ± 7 kgf was found for the dominant hand and 50 ± 9 kgf for the non-dominant hand. For the countermovement jump, the jiu-jitsu athletes reached 41 ± 5 cm. Athletes remained 30 ± 14 s in the maximum static suspension test gripping a kimono, and reached 27 ± 8 cm in the sit-and-reach test. Overall the sample presented average levels of body fat, elevated muscle mass and a predominantly mesomorphic somatotype. Diet was generally poor, with low carbohydrate intake, high protein intake and adequate lipid intake. Maximum isometric handgrip strength was consistent with observations of other athletes in this sport discipline. However, the performance in the maximum static suspension test gripping a kimono was lower than in other Brazilian jiu-jitsu athletes. Movement time was comparable and lower body muscle power was worse compared to athletes in similar sports. Additionally, flexibility was rated as poor.

  10. Evaluation of the Performance of Vortex Generators on the DU 91-W2-250 Profile using Stereoscopic PIV

    DEFF Research Database (Denmark)

    Velte, Clara Marika; Hansen, Martin Otto Laver; Meyer, Knud Erik

    2009-01-01

    Stereoscopic PIV measurements investigating the effect of Vortex Generators on the lift force near stall and on glide ratio at best aerodynamic performance have been carried out in the LM Glasfiber wind tunnel on a DU 91-W2-250 profile. Measurements at two Reynolds numbers were analyzed; Re=0...

  11. Evaluation of the Performance of Vortex Generators on the DU 91-W2-250 Profile using Stereoscopic PIV

    DEFF Research Database (Denmark)

    Velte, Clara Marika; Hansen, Martin Otto Laver; Meyer, Knud Erik

    2008-01-01

    Stereoscopic PIV measurements investigating the effect of Vortex Generators on the lift force near stall and on glide ratio at best aerodynamic performance have been carried out in the LM Glasfiber wind tunnel on a DU 91-W2-250 profile. Measurements at two Reynolds numbers were analyzed; Re=0...

  12. Profile of the appendectomies performed in the Brazilian Public Health System.

    Science.gov (United States)

    Santos, Fernanda Dos; Cavasana, Gabriel Flamarim; Campos, Tercio DE

    2017-01-01

    to analyze the profile of appendectomies performed in the Brazilian Public Health System (SUS) and to compare the laparoscopic and laparotomic techniques of appendectomy. This work used information from DataSus from 2008 to 2014 (http://datasus.saude.gov.br). We compared the data of patients submitted to laparotomic appendectomy with those submitted to laparoscopic one. when comparing the total growth of appendectomies, the laparoscopic route increased 279.7%, while the increase in laparotomic surgery was 25% (p Sistema de Saúde Pública (SUS) do Brasil e comparar as técnicas de apendicectomia, por via laparoscópica e laparotômica. este trabalho utilizou informações do DataSus de 2008 a 2014 (http://datasus.saude.gov.br). Foram comparados os dados dos doentes submetidos à apendicectomia laparotômica com aqueles submetidos à apendicectomia laparoscópica. ao se comparar o crescimento total das apendicectomias, a via laparoscópica aumentou 279,7%, enquanto o aumento da cirurgia laparotômica foi 25% (pSistema Único de Saúde (SUS) com custo médio 7,6% inferior ao das cirurgias por via laparotômica, porém sem significância estatística. A taxa de mortalidade foi 57,1% menor na via laparoscópica quando comparado com a laparotômica. vem havendo um aumento significativo da via laparoscópica no tratamento das apendicites, mas o método ainda é pouco utilizado nos doentes do SUS. Os custos da apendicectomia laparoscópica se mostraram semelhantes aos observados nos acessos laparotômicos.

  13. Game location and team quality effects on performance profiles in professional soccer.

    Science.gov (United States)

    Lago-Peñas, Carlos; Lago-Ballesteros, Joaquin

    2011-01-01

    Home advantage in team sports has an important role in determining the outcome of a game. The aim of the present study was to identify the soccer game- related statistics that best discriminate home and visiting teams according to the team quality. The sample included all 380 games of the Spanish professional men's league. The independent variables were game location (home or away) and the team quality. Teams were classified into four groups according to their final ranking at the end of the league. The game-related statistics registered were divided into three groups: (i) variables related to goals scored; (ii) variables related to offense and (iii) variables related to defense. A univariate (t-test and Mann-Whitney U) and multivariate (discriminant analysis) analysis of data was done. Results showed that home teams have significantly higher means for goal scored, total shots, shots on goal, attacking moves, box moves, crosses, offsides committed, assists, passes made, successful passes, dribbles made, successful dribbles, ball possession, and gains of possession, while visiting teams presented higher means for losses of possession and yellow cards. In addition, the findings of the current study confirm that game location and team quality are important in determining technical and tactical performances in matches. Teams described as superior and those described as inferior did not experience the same home advantage. Future research should consider the influence of other confounding variables such as weather conditions, game status and team form. Key pointsHome teams have significantly higher figures for attack indicators probably due to facilities familiarity and crowd effects.The teams' game-related statistics profile varied according to game location and team quality.Teams described as superior and those described as inferior did not experience the same home advantage.

  14. Ultra-high-performance liquid chromatography profiling method for chemical screening of proanthocyanidins in Czech hops.

    Science.gov (United States)

    Olšovská, J; Kameník, Z; Čejka, P; Jurková, M; Mikyška, A

    2013-11-15

    Hops represent an important natural source of bioactive polyphenols, particularly proanthocyanidins, which can contribute to prevention of several civilization diseases, owing to their antioxidant and radical scavenging activity. We have developed a high-throughput ultra-high-performance liquid chromatography time-of-flight mass spectrometry profiling method, which can be used for monitoring of bioactive proanthocyanidins in hops. The method was applied for analysis of hops of four Czech varieties (Saaz, Sladek, Preminat and Agnus) from the 2011 crop (9 localities, 11 samples) and the 2012 crop (24 localities, 40 samples). Hop samples were extracted by acetone and the analytes were separated on the Acquity UPLC BEH Shield RP18 column. Partial validation of the method revealed a satisfactory intra-day repeatability of the method for retention times (relative standard deviation within 1.39%) as well as areas under the peaks (within 9.89%). Experimental data were evaluated using principal component analysis and cluster analysis. Significant amounts of di-, tri- and tetramer proanthocyanidins consisting of (epi)catechin and (epi)gallocatechin were found in the hop samples. The dependence of the proantocyanidin composition on both the variety and the growing locality was observed. Specifically, the traditional Saaz variety contained more frequently oligomers formed by (epi)catechin units only, whereas the varieties Premiant and Agnus produced oligomers consisting of (epi)catechin as well as (epi)gallocatechin units. The relative abundance of proanthocyanidins in studied hop varieties from the two crops, 2011 and 2012, did correspond to each other. In the further perspective, the method may also be used for prediction of qualitative marks or authenticity verification of hops.

  15. Profiles of exercise motivation, physical activity, exercise habit, and academic performance in Malaysian adolescents: A cluster analysis

    OpenAIRE

    Hairul Anuar Hashim; Freddy Golok; Rosmatunisah Ali

    2011-01-01

    Objectives: This study examined Malaysian adolescents’ profiles of exercise motivation, exercise habit strength, academic performance, and levels of physical activity (PA) using cluster analysis.Methods: The sample (n = 300) consisted of 65.6% males and 34.4% females with a mean age of 13.40 ± 0.49. Statistical analysis was performed using cluster analysis.Results: Cluster analysis revealed three distinct cluster groups. Cluster 1 is characterized by a moderate level of PA, relatively high in...

  16. Serum protein profile study of normal and cervical cancer subjects by high performance liquid chromatography with laser-induced fluorescence.

    Science.gov (United States)

    Sujatha; Rai, Lavanya; Kumar, Pratap; Mahato, Krishna K; Kartha, Vasudevan B; Santhosh, Chidangil

    2008-01-01

    High performance liquid chromatography with high sensitivity laser-induced fluorescence detection is used to study the protein profiles of serum samples from healthy volunteers and cervical cancer subjects. The protein profiles are subjected to principal component analysis (PCA). PCA shows that the large number of chromatograms of a given class of serum samples--say normal/malignant--can be expressed in terms of a small number of factors (principal components). Three parameters--scores of the factors, squared residuals, and Mahalanobis distance--are derived from PCA. The parameters are observed to have a narrow range for protein profiles of standard calibration sets formed from groups of clinically confirmed normal/malignant classes. Limit tests using match/no match of the parameters of any test sample with parameters derived for the standard calibration sets give very good discrimination between malignant and normal samples with high sensitivity (approximately 100%) aand specificity (approximately 94%).

  17. Serum protein profile study of clinical samples using high performance liquid chromatography-laser induced fluorescence: case of cervical and oral cancers

    Science.gov (United States)

    Karemore, Gopal; Sujatha, .; Rai, Lavanya; Pai, Keerthilatha M.; Kartha, V. B.; Santhosh C., .

    2009-02-01

    The serum protein profiles of normal subjects, patients diagnosed with cervical cancer, and oral cancer were recorded using High Performance Liquid Chromatography combined with Laser Induced Fluorescence detection (HPLC-LIF). Serum protein profiles of the above three classes were tested for establishing the ability of HPLC-LIF protein profiling technique for discrimination, using hard clustering and Fuzzy clustering methods. The clustering algorithms have quite successfully classified the profiles as belonging to normal, cancer of cervix, and oral cancer conditions.

  18. Study for the Forming Principle of Logix Gear Tooth Profile and Its Mesh Performance

    Institute of Scientific and Technical Information of China (English)

    Lee; Leckseng; Linda; Lee

    2002-01-01

    In recent years, a new type of gear named Logix gea r was developed. Actually, the tooth profile of this new type of gear is composed of lots of micro-segment involute curves, and on the profile, there exist lots of points, which their relative curvatures are equal to zero. This can result in the sliding coefficient smaller between two meshed Logix gears, and the mesh ch aracteristic becomes almost rolling transmission from sliding transmission accor dingly. So, this new type of gear has lots of advanta...

  19. TRIGONOMETRIC CURVE MODIFICATION OF SCROLL PROFILE AND ITS EFFECT ON PERFORMANCES OF A SCROLL COMPRESSOR

    Institute of Scientific and Technical Information of China (English)

    Liu Tao; Liu Zhenquan

    2005-01-01

    A modification of central profile with trigonometric curve is proposed based on the theory of engagement of scroll compressor. General modification equations for central profile of a pair of scrolls are given and various modification patterns are discussed. The equidistant method is employed to calculate the volume of a sealed chamber and a set of general equations is represented. Modification parameters affecting geometric and dynamic property of a scroll compressor are analyzed systematically, and the relations between them are accurately determined. The condition for transforming a trigonometric curve modification into an arc-curve modification is explained. The conclusions can also be applied to other scroll fluid machines.

  20. A Profile of Advanced Writing Performance: Putting Some Flesh on the Bones

    Science.gov (United States)

    Morgan, Siân

    2012-01-01

    The "Common European Framework of Reference for Languages" (CEFR) has prompted much reflection on language testing and raised awareness of the importance of standardisation in assessing English for academic and professional purposes in an increasingly globalised world. Criticism has nevertheless been levelled at CEFR profiles for being…

  1. Kinanthropometric Profile and Physical Performance of Athletic Track Events in Relation to Different Runners

    Science.gov (United States)

    Khan, Zamirullah; ahmed, Naseem; Raja, Waseem Hassan

    2016-01-01

    The purpose of this study was to find out kinanthropometric profile of 20 Athletes of middle distance 800 meters, & long distance runners 5000 meters of Track Event of age 17 years were assessed for the present study. The data of athletes was collected at Athletics Summer Camp 2015 in Kashmir region. The athletes having participation of at…

  2. Building America Top Innovations 2013 Profile – High-Performance Furnace Blowers

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2013-09-01

    This Top Innovations profile describes Lawrence Berkeley National Laboratory's work with furnace blower design that led to the creation of a standard for rating blowers, credits for the use of good blowers in Federal tax credit programs and energy codes, and consideration in current federal rulemaking procedures.

  3. Automated and unbiased classification of chemical profiles from fungi using high performance liquid chromatography

    DEFF Research Database (Denmark)

    Hansen, Michael Edberg; Andersen, Birgitte; Smedsgaard, Jørn

    2005-01-01

    In this paper we present a method for unbiased/unsupervised classification and identification of closely related fungi, using chemical analysis of secondary metabolite profiles created by HPLC with UV diode array detection. For two chromatographic data matrices a vector of locally aligned full sp...

  4. SOCIO -DEMOGRAPHY, PERSONALITY PROFILE AND ACADEMIC PERFORMANCE OF VARIOUS CATEGORIES OF MEDICAL STUDENTS

    OpenAIRE

    Jiloha, R C; Kishore, Jugal

    1998-01-01

    To compare the Scheduled Caste (SC) & Scheduled Tribe (ST) students with general students regarding their school and family background, personality profile and personal problems, a stratified systematic sample of 261 medical students was taken who filled up their individual set of questionnaires consisting of semistructured sociodemographic proforma, Personality Trait Inventory (PTI) and Students Personal Problems Index. Statistically significant differences were observed when schooling, fami...

  5. Reading Comprehension Assessment through Retelling: Performance Profiles of Children with Dyslexia and Language-Based Learning Disability

    OpenAIRE

    Kida, Adriana de S. B.; de Ávila, Clara R. B.; Capellini, Simone A.

    2016-01-01

    Purpose: To study reading comprehension performance profiles of children with dyslexia as well as language-based learning disability (LBLD) by means of retelling tasks. Method: One hundred and five children from 2nd to 5th grades of elementary school were gathered into six groups: Dyslexia group (D; n = 19), language-based learning disability group (LBLD; n = 16); their respective control groups paired according to different variables – age, gender, grade and school system (public or priva...

  6. Growth performance, carcass characteristics, meat quality and muscle amino-acid profile of different rabbits breeds and their crosses.

    Science.gov (United States)

    Nasr, Mohammed A F; Abd-Elhamid, Tamer; Hussein, Mohamed A

    2017-12-01

    Meat production efficiency can be enhanced by crossbreeding to capture heterosis. This study aimed to investigate the impact of rabbit genotype on growth performance, carcass traits, meat quality and amino acids profile. A total of 504 weaned rabbits from nine genotypes of full factorial crossing of New Zealand White (NZW), Californian (CA) and Rex (RX) were used. Longissimus thoracis et lumborum muscles were assessed for meat quality and amino acids profile. There were no differences between groups at weaning and 6weeks, but by 10weeks differences were significant (P<0.001) and the numerically heaviest groups were CA×RX and RX×NZW (1970g, P<0.001) with to some extent better amino acids profile. In conclusion, RX growth performance was improved by crossing CA sire with RX dam and RX sire with NZW dam and to have dual purpose breed with better growth performance without hazard on carcass and meat quality. CA×RX and RX×NZW had the heaviest body weight at 10weeks of age and highest body weight gain during the whole finishing period. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Effect of Gaussian doping profile on the performance of a thin film polycrystalline solar cell

    OpenAIRE

    2012-01-01

    A two-dimensional (2D) analytical model based on the Green’s function method is applied to an n+-p thin film polycrystalline solar cell that allows us to calculate the conversion efficiency. This model considers the effective Gaussian doping profile in the p region in order to improve cell efficiency. The dependence of mobility and lifetime on grain doping is also investigated. This model is implemented through a simulation program in order to optimize conversion efficiency while varying thic...

  8. Influence of ion-implanted profiles on the performance of GaAs MESFET's and MMIC amplifiers

    Energy Technology Data Exchange (ETDEWEB)

    Pavlidis, D.; Cazaux, J.L.; Graffeuil, J.

    1988-04-01

    The RF small-signal performance of GaAs MESFET's and MMIC amplifiers as a function of various ion-implanted profiles is theoretically and experimentally investigated. Implantation energy, dose, and recess depth influence are theoretically analyzed with the help of a specially developed device simulator. The performance of MMIC amplifiers processed with various energies, doses, recess depths, and bias conditions is discussed and compared to experimental characteristics. Some criteria are finally proposed for the choice of implantation conditions and process in order to optimize the characteristics of ion-implanted FET's and to realize process-tolerant MMIC amplifiers.

  9. Performance Evaluation of Profile Modifier GPJ%调剖剂GPJ的性能评价

    Institute of Scientific and Technical Information of China (English)

    鲁娟党; 阚艳娜; 李贤旭; 李泽; 王召堂

    2012-01-01

    For the heterogeneous sandstone formation with high water-cut, it is characteristic of high permeability channel and great interlayer differences. It is difficult to get better effect of increasing oil production and decreasing water cut by the regular low dose and short radius profile control. In this paper, the relative properties of the developed profile control agent GPJ was evaluated and the profile modification system was investigated, composed of 3% GPJ + 5% bentonite. The profile control effects of the profile control agent system were investigated. The results showed that the developed profile control agent GPJ had good water dispersivity and colloid stability, an electrokinetic potential of 1% PGJ suspensions exceeded + 54 mV, and its oil soluble rate was above 94%, the size distribution of the particles ranged in 5-80μm and media particle size was of 28 μm. When 1 PV of the profile modification system was injected into the sand packed tube model with water permeability of 10.0678-11. 7883 μm^2, the plugging rate could exceed up to 95%. The system was characterized by strong plugging efficiency and washbrush resistance, and the effect in field application was remarkable.%高含水非均质砂岩地层存在高渗透大孔道且层间差异大,常规的小剂量、短半径调剖很难达到增油降水的效果。本文室内考察了合成调剖剂GPJ的基本性能,得到了最佳调剖剂体系的配方:3%GPJ+5%膨润土,着重考察了该调剖剂体系的调剖性能。结果表明,所研制的调剖剂GPJ的水分散性及胶体稳定均良好;1%GPJ悬浮液的电动电位在+54mV以上,带有较高的正电荷;GPJ的油溶率高迭94%;GPJ悬浮液的粒度分布在5-80pan,粒径中值为28μm。当3%GPJ+5%膨润土调剖荆体系的注入量为1PV时,其对水测渗透率为10.0678-11.7883pan。的填砂管模型的封堵率高达95%以上。该调剖剂体系封堵率高,耐冲刷性能好,

  10. Large-scale profiling of diterpenoid glycosides from Stevia rebaudiana using ultrahigh performance liquid chromatography/tandem mass spectrometry.

    Science.gov (United States)

    Shafii, Behnaz; Vismeh, Ramin; Beaudry, Randy; Warner, Ryan; Jones, A Daniel

    2012-07-01

    The plant Stevia rebaudiana accumulates a suite of diterpenoid metabolites that are natural sweeteners finding increased use as sugar substitutes. To guide breeding of stevia plants that accumulate substances with desirable flavor in high yield, rapid and accurate methods are needed to profile these substances in plant populations. This report describes an 8-min ultrahigh performance liquid chromatography-tandem mass spectrometry method for separation and quantification of seven stevia glycosides including steviolbioside; stevioside; rebaudiosides A, B, and C; rubusoside; and dulcoside as well as aglycones steviol and isosteviol. This negative mode electrospray ionization/multiple reaction monitoring method yielded low limits of detection stevia glycosides. Stevioside and Reb A, B, and C were quantified in more than 1,100 extracts from stevia leaves as part of a large-scale profiling exercise. Leaf tissue levels in this population spanned about two orders of magnitude for stevioside (2-125 mg/g dry weight), Reb A (2.5-164 mg/g), Reb B (0.5-50 mg/g), and Reb C (1.5-125 mg/g), but levels of individual metabolites exhibited independent variation. The wide spread of metabolite levels highlights the utility and importance of performing targeted metabolic profiling for large plant populations.

  11. Ultra performance liquid chromatography analysis to study the changes in the carotenoid profile of commercial monovarietal fruit juices.

    Science.gov (United States)

    Delpino-Rius, Antoni; Eras, Jordi; Marsol-Vall, Alexis; Vilaró, Francisca; Balcells, Mercè; Canela-Garayoa, Ramon

    2014-02-28

    We have developed an analytical method that allows the simultaneous determination of epoxycarotenoids, hydroxycarotenoids and carotenes in monovarietal fresh homemade and industrially processed fruit products. Analyses were carried out using ultra performance liquid chromatography (UPLC). The extraction method was optimized using methanol as the first extraction solvent for lyophilized samples followed by a saponification step. Recoveries ranged between 75% and 104% depending on the compound. Repeatability was better than 10% for all compounds (%RSD, n=3). The chromatographic analysis takes less than 17min. In this short period, up to 27 carotenoids were identified in apple, peach and pear products. The developed method allowed us to differentiate juice from six varieties of apple by their carotenoid profile. Moreover, the methodology allows us to differentiate the carotenoid profiles from commercial juices and homemade fresh peach and pear juices, as well as to study the rearrangements of 5,6- to 5,8-epoxycarotenoids.

  12. A conceptual framework for a sports knee injury performance profile (SKIPP) and return to activity criteria (RTAC)

    Science.gov (United States)

    Logerstedt, David; Arundale, Amelia; Lynch, Andrew; Snyder-Mackler, Lynn

    2015-01-01

    Injuries to the knee, including intra-articular fractures, ligamentous ruptures, and meniscal and articular cartilage lesions, are commonplace within sports. Despite advancements in surgical techniques and enhanced rehabilitation, athletes returning to cutting, pivoting, and jumping sports after a knee injury are at greater risk of sustaining a second injury. The clinical utility of objective criteria presents a decision-making challenge to ensure athletes are fully rehabilitated and safe to return to sport. A system centered on specific indicators that can be used to develop a comprehensive profile to monitor rehabilitation progression and to establish return to activity criteria is recommended to clear athletes to begin a progressive and systematic approach to activities and sports. Integration of a sports knee injury performance profile with return to activity criteria can guide clinicians in facilitating an athlete's safe return to sport, prevention of subsequent injury, and life-long knee joint health. PMID:26537805

  13. A conceptual framework for a sports knee injury performance profile (SKIPP and return to activity criteria (RTAC

    Directory of Open Access Journals (Sweden)

    David Logerstedt

    2015-10-01

    Full Text Available ABSTRACTInjuries to the knee, including intra-articular fractures, ligamentous ruptures, and meniscal and articular cartilage lesions, are commonplace within sports. Despite advancements in surgical techniques and enhanced rehabilitation, athletes returning to cutting, pivoting, and jumping sports after a knee injury are at greater risk of sustaining a second injury. The clinical utility of objective criteria presents a decision-making challenge to ensure athletes are fully rehabilitated and safe to return to sport. A system centered on specific indicators that can be used to develop a comprehensive profile to monitor rehabilitation progression and to establish return to activity criteria is recommended to clear athletes to begin a progressive and systematic approach to activities and sports. Integration of a sports knee injury performance profile with return to activity criteria can guide clinicians in facilitating an athlete's safe return to sport, prevention of subsequent injury, and life-long knee joint health.

  14. Vertical Profiles of the 3-D Wind Velocity Retrieved from Multiple Wind Lidars Performing Triple Range-Height-Indicator Scans

    Energy Technology Data Exchange (ETDEWEB)

    Debnath, Mithu; Iungo, G. Valerio; Ashton, Ryan; Brewer, W. Alan; Choukulkar, Aditya; Delgado, Ruben; Lundquist, Julie K.; Shaw, William J.; Wilczak, James M.; Wolfe, Daniel

    2017-02-06

    Vertical profiles of 3-D wind velocity are retrieved from triple range-height-indicator (RHI) scans performed with multiple simultaneous scanning Doppler wind lidars. This test is part of the eXperimental Planetary boundary layer Instrumentation Assessment (XPIA) campaign carried out at the Boulder Atmospheric Observatory. The three wind velocity components are retrieved and then compared with the data acquired through various profiling wind lidars and high-frequency wind data obtained from sonic anemometers installed on a 300 m meteorological tower. The results show that the magnitude of the horizontal wind velocity and the wind direction obtained from the triple RHI scans are generally retrieved with good accuracy. However, poor accuracy is obtained for the evaluation of the vertical velocity, which is mainly due to its typically smaller magnitude and to the error propagation connected with the data retrieval procedure and accuracy in the experimental setup.

  15. Profiles of Mathematics Performance by Students of Chilean City Schools, Based on Cognitive Ability by Socioeconomic Level

    Directory of Open Access Journals (Sweden)

    Mario Tirso Oscar Baltra San Martín

    2010-05-01

    Full Text Available This study analyzes the performance profile of Chilean city-school students from different socioeconomic strata, in relation to different sets of cognitive abilities specified in the curriculum framework for mathematics education in their country. The study is correlational and ex post facto in type, derived from the results of the math test of the System for Measuring Educational Quality (SIMCE applied to second-semester students of the 2001 school year. The percentage of students at each performance level was calculated, based on each student’s probability of correctly answering each of the test questions, using logistic function, associated with the two-parameter model of the Item Response Theory (IRT. The results show that regardless of the set of cognitive abilities in question, the performance profile follows a similar pattern. It was found that in general, there is a linear decrease in the percentage of those who achieve superior performances among students from low and medium-low strata, and exponential increases for middle-class students.

  16. Human performance profiles for planetary analog extra-vehicular activities: 120 day and 30 day analog missions

    Science.gov (United States)

    Swarmer, Tiffany M.

    Understanding performance factors for future planetary missions is critical for ensuring safe and successful planetary extra-vehicular activities (EVAs). The goal of this study was to gain operational knowledge of analog EVAs and develop biometric profiles for specific EVA types. Data was collected for a 120 and 30 day analog planetary exploration simulation focusing on EVA type, pre and post EVA conditions, and performance ratings. From this five main types of EVAs were performed: maintenance, science, survey/exploratory, public relations, and emergency. Each EVA type has unique characteristics and performance ratings showing specific factors in chronological components, environmental conditions, and EVA systems that have an impact on performance. Pre and post biometrics were collected to heart rate, blood pressure, and SpO2. Additional data about issues and specific EVA difficulties provide some EVA trends illustrating how tasks and suit comfort can negatively affect performance ratings. Performance decreases were noted for 1st quarter and 3rd quarter EVAs, survey/exploratory type EVAs, and EVAs requiring increased fine and gross motor function. Stress during the simulation is typically higher before the EVA and decreases once the crew has returned to the habitat. Stress also decreases as the simulation nears the end with the 3rd and 4th quarters showing a decrease in stress levels. Operational components and studies have numerous variable and components that effect overall performance, by increasing the knowledge available we may be able to better prepare future crews for the extreme environments and exploration of another planet.

  17. A control performance analysis for MacPherson active suspension system under bounce sine sweep road profile

    Science.gov (United States)

    Ismail, M. Fahezal; Sam, Yahaya Md.; Sudin, Shahdan; Aripin, M. Khairi

    2016-10-01

    This paper studies a control performance analysis for MacPherson active suspension system. The ride comfort quality is a very important specification for modern automotive suspension system. The Proportional Integral Sliding Mode Control-Evolutionary Strategy-Composite Nonlinear Feedback (PISMC-ES-CNF) controller is designed to solve the transient problem occurred in vertical acceleration of sprung mass. The control performance is tested by using PISMC-ES-CNF and compared with Sliding Mode Controller (SMC) and Composite Nonlinear Feedback (CNF) under Bounce Sine Sweep road profile. The ISO 2631-1, 1997 is a standard for vertical acceleration of sprung mass level and degree of comfort. The one way Analysis of Variance (ANOVA) and standard deviation have showed that the PISMC- ES-CNF controller compared with others controllers achieved the best control performance.

  18. Effects of a Nonuniform Tip Clearance Profile on the Performance and Flow Field in a Centrifugal Compressor

    Directory of Open Access Journals (Sweden)

    Yohan Jung

    2012-01-01

    Full Text Available This paper presents a numerical investigation of the effects of a nonuniform tip clearance profile on the performance and flow field in a centrifugal compressor with a vaneless diffuser. This study focuses in particular on the magnitude and location of the wake. Six impellers with different tip clearance profiles were tested in the flow simulations. The accuracy of the numerical simulations was assessed by comparing the experimental data with the computational results for a system characterized by the original tip clearance. Although the performance improved for low tip clearances, a low tip clearance at the trailing edge improved the compressor performance more significantly than a low tip clearance at the leading edge. The flow field calculated for a system characterized by a low tip clearance at the trailing edge produced a more uniform velocity distribution both in the circumferential and in the axial directions at the impeller exit because the wake magnitude was reduced. As a consequence, this impeller provided a better potential for diffusion processes inside a vaneless diffuser.

  19. A tool to enhance occupational therapy reasoning from ICF perspective: The Hasselt Occupational Performance Profile (H-OPP).

    Science.gov (United States)

    Ghysels, R; Vanroye, E; Westhovens, M; Spooren, A

    2017-03-01

    In order to enhance occupational therapy reasoning in clinical practice, different elements such as client-centred approach, evidence-based care and interdisciplinary work should be taken into account, but is a challenge. To describe the development of the digital Hasselt Occupational Performance Profile (H-OPP(©)) that enhances occupational therapy reasoning from ICF perspective. A participative qualitative design was used to create the H-OPP(©) in an iterative way in which occupational therapy lectures, ICF experts, students and occupational therapists in the field were involved. After linking occupational therapy terminology to the ICF, different stages of the H-OPP were identified and elaborated with main features: generating an occupational performance profile based on inventarization of problems and possibilities, formulating an occupational performance diagnosis and enabling to create an intervention plan. In all stages, both the perspectives of the client and the occupational therapist were taken into account. To increase practical use, the tool was further elaborated and digitalized. The H-OPP(©) is a digital coach that guides and facilitates professional reasoning in (novice) occupational therapists. It augments involvement of the client system. Furthermore, it enhances interdisciplinary communication and evidence-based care.

  20. Performance changes in rowers after training aiming for improvement of the individual physiological profile estimated by five performance trials in four days

    DEFF Research Database (Denmark)

    Jensen, Kurt; Lippets, Rutger; de Boorder, Diederik

    be hypothesed that individual terms should be taken, i.e. that rowers with low max power should be motivated to do special power sessions, and equivalent, less powerful rowers, a program based on steady aerobic work. Hence, they should develop against a more balanced profile. Therefore, the aim of the current......); 2: 2km (W2k); 3: 1 min (W1min); 4: 60 min (W60min). Free stroke rate and drag factor setting were allowed. W2k was used as reference, resulting in a relative intensity in relation to work time: “the power endurance curve” (Jensen, 2007). Training consisted of 30 min in a rowing ergometer, 6 days per...... week, alternating between intensities defined by each rower’s individual performance profile (70-170% W2k). Each session was followed by 45 min in the boat with low intensity (~60-75% W2k). Results The performance increased by 3.5, 5.9, 8.5, 9.5 and 10.1% in W100m; W1min; W2k; W6k; and W6min...

  1. Profiles in Performing Arts Medicine Courage--A Tribute to Dr. Alice Brandfonbrener.

    Science.gov (United States)

    Manchester, Ralph A

    2015-09-01

    I was honored and privileged to join Dr. Robert Sataloff in delivering a tribute to Dr. Alice Brandfonbrener at the 2015 Symposium on the Medical Problems of Performing Artists in Snowmass, Colorado. As virtually everyone who reads this journal knows, Dr. Brandfonbrener organized the first symposium (then focused on the medical problems of musicians), was the founding editor of Medical Problems of Performing Artists, and was the first president of the Performing Arts Medicine Association. She died in 2014, just prior to last year's symposium. This year, after Dr. Sataloff presented a very engaging overview of Alice's career and impressive accomplishments, I gave a short address that was based on some of the editorials Alice wrote in this journal during her 20 year tenure as editor. I have chosen a few examples of how the courage that she demonstrated in launching an international medical conference, a peer-reviewed medical journal, and a professional association continued to present itself in her writing.

  2. Profiling and annotation combined method for multimedia application specific MPSoC performance estimation

    Institute of Scientific and Technical Information of China (English)

    Kai HUANG; Xiao-xu ZHANG; Si-wen XIU; Dan-dan ZHENG; Min YU; De MA; Kai HUANG; Gang CHEN; Xiao-lang YAN

    2015-01-01

    Accurate and fast performance estimation is necessary to drive design space exploration and thus support important design decisions. Current techniques are either time consuming or not accurate enough. In this paper, we solve these problems by presenting a hybrid method for multimedia multiprocessor system-on-chip (MPSoC) performance estimation. A general coverage analysis tool GNU gcov is employed to profi le the execution statistics during the native simulation. To tackle the complexity and keep the analysis and simulation manageable, the orthogonalization of communication and computation parts is adopted. The estimation result of the computation part is annotated to a transaction accurate model for further analysis, by which a gradual refi nement of MPSoC performance estimation is supported. The implementation and its experimental results prove the feasibility and efficiency of the proposed method.

  3. Demographic Profiling--A Determination of Academic Performance in a Postgraduate Diploma in Marketing Management

    Science.gov (United States)

    Beneke, J.; Beeming, C.

    2011-01-01

    This article analyses the direct effect of demographic variables on academic outcomes. The study concludes that ethnic group plays a pivotal role in determining the academic performance of students registered for the Postgraduate Diploma in Marketing Management at the University of Cape Town. White students (presumed to emanate from a privileged…

  4. Web-based evaluation of Parkinson's disease subjects: objective performance capacity measurements and subjective characterization profiles.

    Science.gov (United States)

    Kondraske, George V; Stewart, R Malcolm

    2008-01-01

    Parkinson's Disease (PD) is classified as a progressively degenerative movement disorder, affecting approximately 0.2% of the population and resulting in decreased performance in a wide variety of activities of daily living. Motivated by needs associated with the conduct of multi-center clinical trials, early detection, and the optimization of routine management of individuals with PD, we have developed a three-tiered approach to evaluation of PD and other neurologic diseases/disorders. One tier is characterized as 'web-based evaluation', consisting of objective performance capacity tests and subjective questionnaires that target history and symptom evaluation. Here, we present the initial evaluation of three representative, self-administered, objective, web-based performance capacity tests (simple visual-hand response speed, rapid alternating movement quality, and upper extremity neuromotor channel capacity). Twenty-one subjects (13 with PD, 8 without neurologic disease) were evaluated. Generally good agreement was obtained with lab-based tests executed with an experienced test administrator. We conclude that objective performance capacity testing is a feasible component of a web-based evaluation for PD, providing a sufficient level of fidelity to be useful.

  5. Linking Hydrolysis Performance to Trichoderma reesei Cellulolytic Enzyme Profile

    DEFF Research Database (Denmark)

    Lehmann, Linda Olkjær; Petersen, Nanna; I. Jørgensen, Christian;

    2016-01-01

    Trichoderma reesei expresses a large number of enzymes involved in lignocellulose hydrolysis and the mechanism of how these enzymes work together is too complex to study by traditional methods, e.g. by spiking with single enzymes and monitoring hydrolysis performance. In this study a multivariate...

  6. Wolves--Fact and Fiction: Example Performance Package, Minnesota Profile of Learning.

    Science.gov (United States)

    Minnesota State Dept. of Children, Families, and Learning, St. Paul.

    Developed by classroom teachers during the development phase of Minnesota's Graduation Standards, these performance packages are made up of locally designed assignments that, taken together, show whether a student has learned and can apply the knowledge and skills related to comprehending literal meaning in reading, viewing and listening…

  7. Mystery of Mysteries (Genre Study): Performance Package, Minnesota Profile of Learning.

    Science.gov (United States)

    Minnesota State Dept. of Children, Families, and Learning, St. Paul.

    Developed by classroom teachers during the development phase of Minnesota's Graduation Standards, this performance package is made up of locally designed assignments that, taken together, show whether a student has learned and can apply the knowledge and skills related to answering questions using information gathered through direct observations,…

  8. The Relationship Between the Lower-Body Muscular Profile and Swimming Start Performance

    Directory of Open Access Journals (Sweden)

    García-Ramos Amador

    2016-04-01

    Full Text Available This study aimed to examine the correlation of different dry land strength and power tests with swimming start performance. Twenty international level female swimmers (age 15.3 ± 1.6 years, FINA point score 709.6 ± 71.1 performed the track freestyle start. Additionally, dry land tests were conducted: a squat (SJ and countermovement jumps (CMJ, b squat jumps with additional resistance equivalent to 25, 50, 75 and 100% of swimmers’ body weight [BW], and c leg extension and leg flexion maximal voluntary isometric contractions. Correlations between dry land tests and start times at 5, 10 and 15 m were quantified through Pearson’s linear correlation coefficients (r. The peak bar velocity reached during the jumps with additional resistance was the variable most correlated to swimming start performance (r = -0.57 to -0.66 at 25%BW; r = -0.57 to -0.72 at 50%BW; r = -0.59 to -0.68 at 75%BW; r = -0.50 to - 0.64 at 100%BW. A few significant correlations between the parameters of the SJ and the CMJ with times of 5 and 10 m were found, and none with the isometric variables. The peak velocity reached during jumps with external loads relative to BW was found a good indicator of swimming start performance.

  9. Numerical performance analysis of acoustic Doppler velocity profilers in the wake of an axial-flow marine hydrokinetic turbine

    Energy Technology Data Exchange (ETDEWEB)

    Richmond, Marshall C.; Harding, Samuel F.; Romero Gomez, Pedro DJ

    2015-09-01

    The use of acoustic Doppler current profilers (ADCPs) for the characterization of flow conditions in the vicinity of both experimental and full scale marine hydrokinetic (MHK) turbines is becoming increasingly prevalent. The computation of a three dimensional velocity measurement from divergent acoustic beams requires the assumption that the flow conditions are homogeneous between all beams at a particular axial distance from the instrument. In the near wake of MHK devices, the mean fluid motion is observed to be highly spatially dependent as a result of torque generation and energy extraction. This paper examines the performance of ADCP measurements in such scenarios through the modelling of a virtual ADCP (VADCP) instrument in the velocity field in the wake of an MHK turbine resolved using unsteady computational fluid dynamics (CFD). This is achieved by sampling the CFD velocity field at equivalent locations to the sample bins of an ADCP and performing the coordinate transformation from beam coordinates to instrument coordinates and finally to global coordinates. The error in the mean velocity calculated by the VADCP relative to the reference velocity along the instrument axis is calculated for a range of instrument locations and orientations. The stream-wise velocity deficit and tangential swirl velocity caused by the rotor rotation lead to significant misrepresentation of the true flow velocity profiles by the VADCP, with the most significant errors in the transverse (cross-flow) velocity direction.

  10. Elevation profile influence at key contractual performance parameters for LDS (Leak Detection Systems) based on compensated volume balance

    Energy Technology Data Exchange (ETDEWEB)

    Liebenberg, Lieb [TRANSNET Pipeline, Durban (South Africa); Bueno, David; Passos, Rafaela [KANOPUS Consulting, Rio de Janeiro, RJ (Brazil)

    2009-07-01

    This paper describes and discusses procedures and correlations to estimate performance parameters for Leak Detection Systems based on Compensation Volume Balance, at the portions not usually covered by international standards (like, API RP 1130). These parameters include: minimum acceptable leakage to be detected, under steady state conditions, based on flow measurement uncertainty, observed for both pipeline head and tail; an actual flow rate uncertainty against the one informed by the flow meter manufacturer documentation; the reference flow rate for steady state conditions; and the sensitivity one may expect for the system against a given probability of false alarms (i.e., the ways to correlate reliability, the main performance parameter as per API RP 1130 and sensitivity, the second one). A question usually not considered is: how the elevation profile may affect some of these parameters. That is the second main objective addressed herein, with actual examples employed in a South African multi product pipeline. (author)

  11. Water stress and recovery in the performance of two Eucalyptus globulus clones: physiological and biochemical profiles.

    Science.gov (United States)

    Correia, Barbara; Pintó-Marijuan, Marta; Neves, Lucinda; Brossa, Ricard; Dias, Maria Celeste; Costa, Armando; Castro, Bruno B; Araújo, Clara; Santos, Conceição; Chaves, Maria Manuela; Pinto, Glória

    2014-04-01

    Eucalyptus plantations are among the most productive forest stands in Portugal and Spain, being mostly used for pulp production and, more recently, as an energy crop. However, the region's Mediterranean climate, with characteristic severe summer drought, negatively affects eucalypt growth and increases mortality. Although the physiological response to water shortage is well characterized for this species, evidence about the plants' recovery ability remains scarce. In order to assess the physiological and biochemical response of Eucalyptus globulus during the recovery phase, two genotypes (AL-18 and AL-10) were submitted to a 3-week water stress period at two different intensities (18 and 25% of field capacity), followed by 1 week of rewatering. Recovery was assessed 1 day and 1 week after rehydration. Drought reduced height, biomass, water potential, NPQ and gas exchange in both genotypes. Contrarily, the levels of pigments, chlorophyll fluorescence parameters (F(v) /F(m) and (φPSII)), MDA and ABA increased. During recovery, the physiological and biochemical profile of stressed plants showed a similar trend: they experienced reversion of altered traits (MDA, ABA, E, g(s), pigments), while other parameters did not recover ((φPSII), NPQ). Furthermore, an overcompensation of CO(2) assimilation was achieved 1 week after rehydration, which was accompanied by greater growth and re-establishment of oxidative balance. Both genotypes were tolerant to the tested conditions, although clonal differences were found. AL-10 was more productive and showed a more rapid and dynamic response to rehydration (namely in carotenoid content, (φPSII) and NPQ) compared to clone AL-18. © 2013 Scandinavian Plant Physiology Society.

  12. Formulation parameters affecting the performance of coated gelatin capsules with pulsatile release profiles.

    Science.gov (United States)

    Bussemer, T; Bodmeier, R

    2003-11-28

    The objective of this study was to develop and evaluate a rupturable pulsatile drug delivery system based on soft gelatin capsules with or without a swelling layer and an external water-insoluble but -permeable polymer coating, which released the drug after a lag time (rupturing of the external polymer coating). The swelling of the gelatin capsule itself was insufficient to rupture the external polymer coating, an additional swelling layer was applied between the capsule and the polymer coating. Croscarmellose sodium (Ac-Di-Sol) was more effective as a swelling agent than low and high molecular weight hydroxypropylmethyl cellulose (HPMC; E5 or K100M). Brittle polymers, such as ethyl cellulose (EC) and cellulose acetate propionate (CAPr), led to a better rupturing and therefore more complete drug release than the flexible polymer coating, Eudragit RS. The lag time of the release system increased with higher polymer coating levels and decreased with the addition of a hydrophilic pore-former, HPMC E5 and also with an increasing amount of the intermediate swelling layer. The water uptake of the capsules was linear until rupture and was higher with CAPr than with EC. Soft gelatin capsule-based systems showed shorter lag times compared to hard gelatin capsules because of the higher hardness/filling state of the soft gelatin capsules. The swelling pressure was therefore more directed to the external polymer coating with the soft gelatin capsules. Typical pulsatile drug release profiles were obtained at lower polymer coating levels, while the release was slower and incomplete at the higher coating levels. CAPr-coated capsules resulted in a more complete release than EC-coated capsules.

  13. Effects of high performance inulin supplementation on glycemic status and lipid profile in women with type 2 diabetes: a randomized, placebo-controlled clinical trial

    National Research Council Canada - National Science Library

    Dehghan, Parvin; Pourghassem Gargari, Bahram; Asgharijafarabadi, Mohammad

    2013-01-01

    ... mellitus.It is claimed that functional foods may improve complications of diabetes mellitus, so this study was designed to evaluate the effects of high performance inulin on glycemic status and lipid profile...

  14. Performance-based testing for drugs of abuse: dose and time profiles of marijuana, amphetamine, alcohol, and diazepam.

    Science.gov (United States)

    Kelly, T H; Foltin, R W; Emurian, C S; Fischman, M W

    1993-09-01

    The time courses of the effects of acute doses of amphetamine (5 and 10 mg/70 kg), alcohol (0.3 and 0.6 g/kg), diazepam (5 and 10 mg/70 kg), and marijuana (2.0% and 3.5% delta 9-THC) on performance engendered by each of four computerized behavioral tasks were evaluated in six human subjects. These performance-based tasks have potential commercial utility for drug-use detection in the workplace. Alcohol and marijuana effects were reliably detected for up to three hours following dose administration with most procedures. Amphetamine and diazepam effects were also detected, but the dose effects and time courses were variable. The profile of behavioral effects varied across drugs, suggesting that performance-based testing procedures might be useful in discriminating which drug was administered and the time course of the drug's effects. Results indicate that repeated measurement with performance-based drug detection procedures can provide immediate indications of performance impairment in a cost-effective and noninvasive manner and, as such, would be a useful supplement to biological sample testing for drug-use detection.

  15. Profiles of exercise motivation, physical activity, exercise habit, and academic performance in Malaysian adolescents: A cluster analysis

    Directory of Open Access Journals (Sweden)

    Hairul Anuar Hashim

    2011-06-01

    Full Text Available Objectives: This study examined Malaysian adolescents’ profiles of exercise motivation, exercise habit strength, academic performance, and levels of physical activity (PA using cluster analysis.Methods: The sample (n = 300 consisted of 65.6% males and 34.4% females with a mean age of 13.40 ± 0.49. Statistical analysis was performed using cluster analysis.Results: Cluster analysis revealed three distinct cluster groups. Cluster 1 is characterized by a moderate level of PA, relatively high in motivational indices and relative autonomy index (RAI, low in exercise habit, and moderate level of academic achievement. Cluster 2 has superior academic performance but is low in PA and all other measured variables. Cluster 3 is characterized by high levels of PA and all other variables but is lowest in academic performance. One way ANOVA revealed significant differences between cluster groups in total weekly MET, total minutes of weekly PA, academic performance, introjected regulation, and identified regulation.Conclusion: PA promotion with emphasis on external factors may be effective in instilling exercise habituation among adolescents in the present sample.

  16. Urinary Metabolite Profiles May be Predictive of Cognitive Performance Under Conditions of Acute Sleep Deprivation

    Science.gov (United States)

    2016-01-01

    potential for estimating taurine bioavailability in the adult cat . Adv. Expl. Med. Biol., 1992, 315, 55-62. [61] Lieberman, H.R. Tyrosine and stress ...factors present in these envi- ronments that impact performance include reduced caloric intake, dietary changes, and decision-making induced stress ...grapefruit, or licorice over this same time period. These foods possess high levels of confounding metabolites (i.e., trimethylamine N- oxide in urine of

  17. Recovery time profiling after short-, middle- and long-distance swimming performance.

    Science.gov (United States)

    Piras, Alessandro; Cortesi, Matteo; Campa, Francesco; Perazzolo, Monica; Gatta, Giorgio

    2017-06-22

    We investigated cardiac autonomic responses and hemodynamic parameters on recovery time following short-, middle- and long-swimming performance. Ten male regional-level swimmers were tested to estimate time and frequency domains of arterial baroreflex sensitivity and heart rate variability after 100-, 200-, and 400-m of front crawl. We found a BRS reduction for 90 min after a maximal 100- and 200-m front crawl event, meanwhile the reflex was restored back to the baseline value about 70 min after 400-m. The vagally mediated HF power of R-R intervals was significantly reduced for 30 min after 400-m, and more than 90 min after 100- and 200-m, with a concomitant increase of sympathetic modulation. After 400-m athletes have reduced their stroke volume for 50 min, which remained at the baseline level following 100- and 200-m. HR was restored back after 90 min in all conditions, whereas TPR was significantly reduced for 50 min after 200- and 400-m, with a persistent reduction after 100-m. Time course of autonomic recovery after 3 different swimming performances is influenced by exercise intensity and duration, showing a rapid recovery after 400-m, an intermediate recovery after 200-m, and a significantly delayed recovery after a more strictly anaerobic performance like 100-m of front crawl. These results could encourage coaches to consider that athlete might be affected by the specific recovery time of the previous exercise performed, suggesting that the management of the exercise intensity, and appropriate monitoring of cardiac autonomic parameters might be helpful to know the physical condition of each athlete.

  18. An Algorithm for Glaucoma Screening in Clinical Settings and Its Preliminary Performance Profile

    Directory of Open Access Journals (Sweden)

    S-Farzad Mohammadi

    2013-01-01

    Full Text Available Purpose: To devise and evaluate a screening algorithm for glaucoma in clinical settings. Methods: Screening included examination of the optic disc for vertical cupping (≥0.4 and asymmetry (≥0.15, Goldmann applanation tonometry (≥21 mmHg, adjusted or unadjusted for central corneal thickness, and automated perimetry. In the diagnostic step, retinal nerve fiber layer imaging was performed using scanning laser polarimetry. Performance of the screening protocol was assessed in an eye hospital-based program in which 124 non-physician personnel aged 40 years or above were examined. A single ophthalmologist carried out the examinations and in equivocal cases, a glaucoma subspecialist′s opinion was sought. Results: Glaucoma was diagnosed in six cases (prevalence 4.8%; 95% confidence interval, 0.01-0.09 of whom five were new. The likelihood of making a definite diagnosis of glaucoma for those who were screened positively was 8.5 times higher than the estimated baseline risk for the reference population; the positive predictive value of the screening protocol was 30%. Screening excluded 80% of the initial population. Conclusion: Application of a formal screening protocol (such as our algorithm or its equivalent in clinical settings can be helpful in detecting new cases of glaucoma. Preliminary performance assessment of the algorithm showed its applicability and effectiveness in detecting glaucoma among subjects without any visual complaint.

  19. [Profile and motivations of students performing a universitary degree in 2011].

    Science.gov (United States)

    Darien, M; Wallet, F; Schoeffler, M; Tassin, C; Lieutaud, T; Piriou, V

    2012-11-01

    Observational study relating to the inscriptions with universitary diplomas (DU) in relation with anesthesiology and intensive care during the year 2010-2011. We had in mind to know the profile and the motivations of the students concerned. A questionnaire was put on line and the registered students with the various diplomas were contacted by e-mail. Different items investigated concerned: demography, type of exercise of the students, heading of diplomas, scientific level of the students, their motivations at the time of the inscription and finally practical organization. We collected 265 questionnaires, that is to say 42 % of answers. The demographic distribution of the registered voters was the followed: 71% of MD, 28% of residents. These doctors exerted for the majority with the public hospital (87%). The inscriptions concerned intensive care diplomas in 90% of the cases. The total scientific level of the students was high, since 46% of them had a diploma other than their medicine thesis. The students were registered for the majority of them "to widen their field of competence" (65%) or "in complement of their initial training" (46%). The other reasons were: "to make up a deficit of their initial training (26%)", "as continuous medical training" (16%) and finally "for the university validation of an asset" (10%). The rate of total satisfaction of the diplomas was very high (96%). Financial aid was assumed by the institution for 46% of students. Residents were less financially helped than senior practitioners. The overall costs of the DU/DIU, including the registration fee, transport and lodging, were important (>500 euros in 61% of the cases). DUs related to our specialty are much appreciated. They interest a majority of senior doctors, but also a considerable number of residents, which poses the problem of the place of these additional trainings within the framework of initial training. The principal motivations of the registered voters are to supplement their

  20. Cloning and expression profiling of the VLDLR gene associated with egg performance in duck (Anas platyrhynchos

    Directory of Open Access Journals (Sweden)

    Peng Xiu-li

    2011-08-01

    Full Text Available Abstract Background The very low density lipoprotein receptor gene (VLDLR, a member of the low density lipoprotein receptor (LDLR gene family, plays a crucial role in the synthesis of yolk protein precursors in oviparous species. Differential splicing of this gene has been reported in human, rabbit and rat. In chicken, studies showed that the VLDLR protein on the oocyte surface mediates the uptake of yolk protein precursors into growing oocytes. However, information on the VLDLR gene in duck is still scarce. Methods Full-length duck VLDLR cDNA was obtained by comparative cloning and rapid amplification of cDNA ends (RACE. Tissue expression patterns were analysed by semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR. Association between the different genotypes and egg performance traits was investigated with the general linear model (GLM procedure of the SAS® software package. Results In duck, two VLDLR transcripts were identified, one transcript (variant-a containing an O-linked sugar domain and the other (variant-b not containing this sugar domain. These transcripts share ~70 to 90% identity with their counterparts in other species. A phylogenetic tree based on amino acid sequences showed that duck VLDLR proteins were closely related with those of chicken and zebra finch. The two duck VLDLR transcripts are differentially expressed i.e. VLDLR-a is mainly expressed in muscle tissue and VLDLR-b in reproductive organs. We have localized the duck VLDLR gene on chromosome Z. An association analysis using two completely linked SNP sites (T/C at position 2025 bp of the ORF and G/A in intron 13 and records from two generations demonstrated that the duck VLDLR gene was significantly associated with egg production (P Conclusions Duck and chicken VLDLR genes probably perform similar function in the development of growing oocytes and deposition of yolk lipoprotein. Therefore, VLDLR could be a candidate gene for duck egg performance

  1. Technical activity profile and influence of body anthropometry on playing performance in female elite team handball

    DEFF Research Database (Denmark)

    Michalsik, Lars B; Aagaard, Per; Madsen, Klavs

    2015-01-01

    .4 screenings, received 14.6 ± 9.2 tackles in total, and performed 7.7 ± 3.7 shots while in offense, along with 3.5 ± 3.8 blockings, 1.9 ± 2.7 claspings, and 6.2 ± 3.8 hard tackles in defense. Mean body height, body mass, and age in the Danish Premier Female Team Handball League were 175.4 ± 6.1 cm, 69.5 ± 6...... that female elite TH players during competitive games intermittently perform a high number of short-term, high-intense technical playing actions making modern female elite TH a physically demanding team sport. No sign of technical fatigue were observed, since the amount of intense technical playing actions......To determine the physical demands placed on female elite team handball (TH) players in relation to playing position and body anthropometry, female elite TH primarily field players were monitored during match-play using video recording and subsequent computerized technical match analysis during 5...

  2. NONLINEAR FORCE PROFILE USED TO INCREASE THE PERFORMANCE OF A HAPTIC USER INTERFACE FOR TELEOPERATING A ROBOTIC HAND

    Energy Technology Data Exchange (ETDEWEB)

    Anthony L. Crawford

    2012-07-01

    MODIFIED PAPER TITLE AND ABSTRACT DUE TO SLIGHTLY MODIFIED SCOPE: TITLE: Nonlinear Force Profile Used to Increase the Performance of a Haptic User Interface for Teleoperating a Robotic Hand Natural movements and force feedback are important elements in using teleoperated equipment if complex and speedy manipulation tasks are to be accomplished in hazardous environments, such as hot cells, glove boxes, decommissioning, explosives disarmament, and space. The research associated with this paper hypothesizes that a user interface and complementary radiation compatible robotic hand that integrates the human hand’s anthropometric properties, speed capability, nonlinear strength profile, reduction of active degrees of freedom during the transition from manipulation to grasping, and just noticeable difference force sensation characteristics will enhance a user’s teleoperation performance. The main contribution of this research is in that a system that concisely integrates all these factors has yet to be developed and furthermore has yet to be applied to a hazardous environment as those referenced above. In fact, the most prominent slave manipulator teleoperation technology in use today is based on a design patented in 1945 (Patent 2632574) [1]. The robotic hand/user interface systems of similar function as the one being developed in this research limit their design input requirements in the best case to only complementing the hand’s anthropometric properties, speed capability, and linearly scaled force application relationship (e.g. robotic force is a constant, 4 times that of the user). In this paper a nonlinear relationship between the force experienced between the user interface and the robotic hand was devised based on property differences of manipulation and grasping activities as they pertain to the human hand. The results show that such a relationship when subjected to a manipulation task and grasping task produces increased performance compared to the

  3. A minimal limit-cycle model to profile movement patterns of individuals during agility drill performance: Effects of skill level.

    Science.gov (United States)

    Mehdizadeh, Sina; Arshi, Ahmed Reza; Davids, Keith

    2015-06-01

    Identification of control strategies during agility performance is significant in understanding movement behavior. This study aimed at providing a fundamental mathematical model for describing the motion of participants during an agility drill and to determine whether skill level constrained model components. Motion patterns of two groups of skilled and unskilled participants (n=8 in each) during performance of a forward/backward agility drill modeled as limit-cycles. Participant movements were recorded by motion capture of a reflective marker attached to the sacrum of each individual. Graphical and regression analyses of movement kinematics in Hooke's plane, phase plane and velocity profile were performed to determine components of the models. Results showed that the models of both skilled and unskilled groups had terms from Duffing stiffness as well as Van der Pol damping oscillators. Data also indicated that the proposed models captured on average 97% of the variance for both skilled and unskilled groups. Findings from this study revealed the movement patterning associated with skilled and unskilled performance in a typical forward/backward agility drill which might be helpful for trainers and physiotherapists in enhancing agility.

  4. The Mobile Teachers Profile Competencies Performance And Problems In The Department Of Education Division Of Northern Samar Philippines

    Directory of Open Access Journals (Sweden)

    Estrellita C. Pinca

    2015-08-01

    Full Text Available Abstract This study aimed to describe the profile of the mobile teachers assess their competencies determine the level of their performance and identify the problems they encountered from 2010-2014 in the Department of Education Division of Northern Samar Philippines. The descriptive evaluative research design was used. Questionnaires actual observation focus-group discussion and interview were utilized in gathering the data. All mobile teachers during the conduct of the study served as respondents. Others sources of information were the ALS Education supervisor ALS specialist the District supervisor barangay officials learners and completers. The performance rating given by the District supervisor was used as the basis in determining the work performance of the mobile teachers. The mobile teachers were young adults majorities were males educationally qualified but their formal training were inclined towards the conduct of formal classes. Several mobile teachers have pursued graduate studies geared towards administration and supervision. All were passers of the Licensure Examination for Teachers but were relatively young in service as mobile teachers. They have higher competence in the conduct of learning sessions and have very satisfactory work performance. Their major problems were lack of community-based instructional materials delayed release of travel allowance and absence of permanent room during the conduct of the learning sessions.

  5. EFFECT OF DECREASING DIETARY PROTEIN LEVELS WITH OPTIMAL AMINO ACIDS PROFILE ON THE PERFORMANCE OF BROILERS

    Directory of Open Access Journals (Sweden)

    Z. Kamran, M. Aslam Mirza, Ahsan-ul-Haq1 and S. Mahmood1

    2004-10-01

    Full Text Available A six-week trial was conducted to study the effect of decreasing dietary crude protein (CP level on the performance of broilers in hot climatic conditions. Four experimental rations having CP 23 (control group, 22, 21 and 20%, with optimal amino acid balance were prepared. All the four rations were isocaloric having ME 3200 kcal/kg with Energy: Protein (E:P 139.0, 146.5, 152.4 and 160 in diets A, B, C and D respectively. One hundred and twenty day-old chicks were randomly distributed into 12 experimental units, each having 10 chicks. Rations were randomly allotted to experimental units such that each unit received three replicates. The experimental diets were fed to birds from day 1st to 42nd. Performance of birds was monitored in terms of weight gain, feed consumption and feed conversion ratio (FCR. At the end of experiment, two birds per each replicate were randomly selected and slaughtered to record the data on carcass yield, breast meat yield, abdominal fat and composition of breast meat. Results of the trial suggested that weight gain was significantly (P<0.01 increased in birds on diets with CP 20 and 21%. Feed consumption and FCR remained un-changed for all the treatment groups. Eviscerated carcass yield was significantly (P<0.05 higher for the group fed on diet with 20% CP. Breast meat yield, abdominal fat and composition of breast meat also remained un-changed. Economic evaluation of the trial revealed that decreasing CP levels from 23 to 20% resulted in reduced feed cost per kg of live weight gain, which clearly indicated that this approach was useful especially in severe summer conditions. The overall picture of the study suggests that dietary protein level of broilers could be reduced from 23 to 20%, with beneficial effects on growth performance and carcass characteristics and increased economic returns in hot environmental conditions, provided that levels of essential amino acids are closely looked after.

  6. Reading Comprehension Assessment through Retelling: Performance Profiles of Children with Dyslexia and Language-Based Learning Disability

    Science.gov (United States)

    Kida, Adriana de S. B.; de Ávila, Clara R. B.; Capellini, Simone A.

    2016-01-01

    Purpose: To study reading comprehension performance profiles of children with dyslexia as well as language-based learning disability (LBLD) by means of retelling tasks. Method: One hundred and five children from 2nd to 5th grades of elementary school were gathered into six groups: Dyslexia group (D; n = 19), language-based learning disability group (LBLD; n = 16); their respective control groups paired according to different variables – age, gender, grade and school system (public or private; D-control and LBLD-control); and other control groups paired according to different reading accuracy (D-accuracy; LBLD-accuracy). All of the children read an expository text and orally retold the story as they understood it. The analysis quantified propositions (main ideas and details) and retold links. A retelling reference standard (3–0) was also established from the best to the worst performance. We compared both clinical groups (D and LBLD) with their respective control groups by means of Mann–Whitney tests. Results: D showed the same total of propositions, links and reference standards as D-control, but performed better than D-accuracy in macro structural (total of links) and super structural (retelling reference standard) measures. Results suggest that dyslexic children are able to use their linguistic competence and their own background knowledge to minimize the effects of their decoding deficit, especially at the highest text processing levels. LBLD performed worse than LBLD-control in all of the retelling measures and LBLD showed worse performance than LBLD-accuracy in the total retold links and retelling reference standard. Those results suggest that both decoding and linguistic difficulties affect reading comprehension. Moreover, the linguistic deficits presented by LBLD students do not allow these pupils to perform as competently in terms of text comprehension as the children with dyslexia do. Thus, failure in the macro and super-structural information

  7. Reading Comprehension Assessment through Retelling: Performance Profiles of Children with Dyslexia and Language-Based Learning Disability.

    Science.gov (United States)

    Kida, Adriana de S B; de Ávila, Clara R B; Capellini, Simone A

    2016-01-01

    To study reading comprehension performance profiles of children with dyslexia as well as language-based learning disability (LBLD) by means of retelling tasks. One hundred and five children from 2nd to 5th grades of elementary school were gathered into six groups: Dyslexia group (D; n = 19), language-based learning disability group (LBLD; n = 16); their respective control groups paired according to different variables - age, gender, grade and school system (public or private; D-control and LBLD-control); and other control groups paired according to different reading accuracy (D-accuracy; LBLD-accuracy). All of the children read an expository text and orally retold the story as they understood it. The analysis quantified propositions (main ideas and details) and retold links. A retelling reference standard (3-0) was also established from the best to the worst performance. We compared both clinical groups (D and LBLD) with their respective control groups by means of Mann-Whitney tests. D showed the same total of propositions, links and reference standards as D-control, but performed better than D-accuracy in macro structural (total of links) and super structural (retelling reference standard) measures. RESULTS suggest that dyslexic children are able to use their linguistic competence and their own background knowledge to minimize the effects of their decoding deficit, especially at the highest text processing levels. LBLD performed worse than LBLD-control in all of the retelling measures and LBLD showed worse performance than LBLD-accuracy in the total retold links and retelling reference standard. Those results suggest that both decoding and linguistic difficulties affect reading comprehension. Moreover, the linguistic deficits presented by LBLD students do not allow these pupils to perform as competently in terms of text comprehension as the children with dyslexia do. Thus, failure in the macro and super-structural information processing of the expository text were

  8. Effect of silver nanoparticles on growth performance, metabolism and microbial profile of broiler chickens

    DEFF Research Database (Denmark)

    Pineda, Lane; Chwalibog, André; Sawosz, Ewa

    2012-01-01

    (IgG) in the blood plasma of broilers supplemented with AgNano decreased at day 36 (p = 0.012). The results demonstrated that AgNano affects N utilisation and plasma IgG concentration; however, it does not influence the microbial populations in the digestive tract, the energy metabolism and growth......This study evaluated the potential of silver nanoparticles (AgNano) as an antimicrobial growth-promoting supplement for broiler chickens. One hundred forty-four seven-day-old broiler chicks were distributed randomly to AgNano treatments at 0, 10 and 20 mg/kg (Control, Group AgNano10, and Group Ag...... and intestinal content were collected to evaluate the effects of AgNano on plasma concentration of immunoglobulins and the intestinal microflora, repectively. The provision of water solutions containing different concentrations of AgNano had no effect on postnatal growth performance and the energy metabolism...

  9. THE INFLUENCE OF THE BEHAVIORAL PROFILE UPON THE MANAGEMENT TEAM’S PERFORMANCE

    Directory of Open Access Journals (Sweden)

    Radu Ogarcă

    2015-09-01

    Full Text Available The present paper’s goal were: analysing the relationship between the personalityprofile (determined using the Myers-Briggs Type Indicator and the team role (established with the Belbin Test, identifying the possible correlations between the two and studying the way in which these correlations are influencing the relationships between the team members and the efficiency with which they are fulfilling their tasks. The present research is exploratory and due to its characteristics, the sampling has not been probability-based. Thus, the sample is composed of the members of the executive board of AIESEC Craiova, a non-governmental organisation, active in the youth-work field. Our endeavour is focusing on problem which has been sparsely researched in the best: the analysis of the management team’s performance through two models, which have not been thoroughly studied together (Myers-Briggs Type Indicator and Belbin Team Roles

  10. Effect of Conjugated Linoleic Acid Feeding on the Growth Performance and Meat Fatty Acid Profiles in Broiler: Meta-analysis

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    Sangbuem Cho

    2013-07-01

    Full Text Available The effect of conjugated linoleic acid (CLA feeding on growth performance and fatty acid profiles in thigh meat of broiler chicken was investigated using meta-analysis with a total of 9 studies. Overall effects were calculated by standardized mean differences between treatment (CLA fed and control using Hedges’s adjusted g from fixed and random effect models. Meta-regression was conducted to evaluate the effect of CLA levels. Subgroups in the same study were designated according to used levels of CLA, CP levels or substituted oils in diets. The effects on final body weight, weight gain, feed intake and feed conversion ratio were investigated as growth parameters. Total saturated and unsaturated fatty acid concentrations and C16:0, C18:0, C18:2 and C18:3 concentrations in thigh meat of broiler chicken were used as fatty acid profile parameters. The overall effect of CLA feeding on final weight was negative and it was only significant in fixed effect model (p<0.01. Significantly lower weight gain, feed intake and higher feed conversion ratio compared to control were found (p<0.05. CLA feeding on the overall increased total saturated fatty acid concentration in broilers compared to the control diet (p<0.01. Total unsaturated fatty acid concentration was significantly decreased by CLA feeding (p<0.01. As for individual fatty acid profiles, C16:0, C18:0 and C18:3 were increased and C18:2 was significantly decreased by CLA feeding (p<0.01. In conclusion, CLA was proved not to be beneficial for improving growth performance, whereas it might be supposed that CLA is effective modulating n-6/n-3 fatty acids ratio in thigh meat. However, the economical compensation of the loss from suppressed growth performance and increased saturated fatty acids with the benefit from enhanced n-6/n-3 ratio should be investigated in further studies in order to propose an appropriate use of dietary CLA in the broiler industry.

  11. Change of direction ability performance in cerebral palsy football players according to functional profiles

    Directory of Open Access Journals (Sweden)

    Raul eReina

    2016-01-01

    Full Text Available The aims of the present study were to evaluate the validity and reliability of the two different change of direction ability (CODA tests in elite football players with cerebral palsy (CP and to analyse the differences in performance of this ability between current functional classes (FT and controls. The sample consisted of 96 international cerebral palsy football players (FPCP and 37 football players. Participants were divided into four different groups according to the International Federation of Cerebral Palsy Football classes and a control group (CG: FT5 (n = 8; FT6 (n = 12; FT7 (n = 62; FT8 (n = 14; and CG (n = 37. The reproducibility of Modified Agility Test (MAT and Illinois Agility Test (IAT (ICC = 0.82-0.95, SEM = 2.5-5.8% showed excellent to good values. In two CODA tests, CG performed faster scores compared with FPCP classes (p < 0.01, d = 1.76-3.26. In IAT, FT8 class comparisons regarding the other classes were: FT5 (p = 0.047, d = 1.05, FT6 (p = 0.055, d = 1.19 and FT7 (p = 0.396, d = 0.56. With regard to MAT, FT8 class was also compared with FT5 (p = 0.006, d = 1.30, FT6 (p = 0.061, d = 0.93 and FT7 (p = 0.033, d = 1.01. No significant differences have been found between FT5, FT6 and FT7 classes. According to these results, IAT and MAT could be useful and reliable and valid tests to analyse CODA in FPCP. Each test (IAT and MAT could be applied considering the cut point that classifiers need to make a decision about the FT8 class and the other FT classes (FT5, FT6 and FT7.

  12. Effect of beef tallow on growth performance, carcass characteristics, meat composition, and lipid profile of growing lambs

    Directory of Open Access Journals (Sweden)

    Shahana Ahmed

    2015-09-01

    Full Text Available The objective of this study was to investigate the effect of diets with inclusion of beef tallow on growth, and carcass characteristics, meat quality, and lipid profile in growing lambs. The experiment was conducted with 15 lambs for 63 days. The lambs were randomly allotted into three dietary treatments (T0, T1, and T2 with five animals in each group; T0 (control diet without beef tallow, T1 (diet with 2% beef tallow, and T2 (diet with 4% beef tallow. The body weight and feed conversion ratio (FCR were significantly (P0.05 on meat quality and chemical composition among the three dietary groups. Group T1 showed the highest increase of cholesterol concentration (11.5% at the end of experiment, but serum triglyceride concentration was not significantly (P>0.05 correlated with any of the three dietary groups. To sum up, the use of beef tallow at 2% level in lamb diet can increase their performance without having any deleterious effect on carcass, meat quality and lipid profile. [J Adv Vet Anim Res 2015; 2(3.000: 346-352

  13. Computational modeling and experimental studies of the dynamic performance of ultrasonic horn profiles used in plastic welding.

    Science.gov (United States)

    Roopa Rani, M; Rudramoorthy, R

    2013-03-01

    Ultrasonic horns are tuned components designed to vibrate in a longitudinal mode at ultrasonic frequencies. Reliable performance of such horns is normally decided by the uniformity of vibration amplitude at the working surface and the stress developed during loading condition. The horn design engineer must pay particular attention to designing a tool that will produce the desired amplitude without fracturing. The present work discusses horn configurations which satisfy these criteria and investigates the design requirements of horns in ultrasonic system. Different horn profiles for ultrasonic welding of thermoplastics have been characterized in terms of displacement amplitude and von-Mises stresses using modal and harmonic analysis. To validate the simulated results, five different horns are fabricated from Aluminum, tested and tuned to the operating frequency. Standard ABS plastic parts are welded using these horns. Temperature developed during the welding of ABS test parts using different horns is recorded using sensors and National Instruments (NIs) data acquisition system. The recorded values are compared with the predicted values. Experimental results show that welding using a Bezier horn has a high interface temperature and the welded joints had higher strength as compared to the other horn profiles.

  14. Profiling the Metabolism of Astragaloside IV by Ultra Performance Liquid Chromatography Coupled with Quadrupole/Time-of-Flight Mass Spectrometry

    Directory of Open Access Journals (Sweden)

    Xu-Dong Cheng

    2014-11-01

    Full Text Available Astragaloside IV is a compound isolated from the Traditional Chinese Medicine Astragalus membranaceus, that has been reported to have bioactivities against cardiovascular disease and kidney disease. There is limited information on the metabolism of astragaloside IV, which impedes comprehension of its biological actions and pharmacology. In the present study, an ultra-performance liquid chromatography coupled with quadrupole/time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS-based approach was developed to profile the metabolites of astragaloside IV in rat plasma, bile, urine and feces samples. Twenty-two major metabolites were detected. The major components found in plasma, bile, urine and feces included the parent chemical and phases I and II metabolites. The major metabolic reactions of astragaloside IV were hydrolysis, glucuronidation, sulfation and dehydrogenation. These results will help to improve understanding the metabolism and reveal the biotransformation profiling of astragaloside IV in vivo. The metabolic information obtained from our study will guide studies into the pharmacological activity and clinical safety of astragaloside IV.

  15. Untargeted metabolomic profiling of amphenicol-resistant Campylobacter jejuni by ultra-high-performance liquid chromatography-mass spectrometry.

    Science.gov (United States)

    Li, Hui; Xia, Xi; Li, Xiaowei; Naren, Gaowa; Fu, Qin; Wang, Yang; Wu, Congming; Ding, Shuangyang; Zhang, Suxia; Jiang, Haiyang; Li, Jiancheng; Shen, Jianzhong

    2015-02-06

    Campylobacter jejuni, an important foodborne microorganism, poses severe and emergent threats to human health as antibiotic resistance becomes increasingly prevalent. The mechanisms of drug resistance are hard to decipher, and little is known at the metabolic level. Here we apply metabolomic profiling to discover metabolic changes associated with amphenicol (chloramphenicol and florfenicol) resistance mutations of Campylobacter jejuni. An optimized sample preparation method was combined with ultra-high-performance liquid chromatography-time-of-flight mass spectrometry (UHPLC-TOF/MS) and pattern recognition for the analysis of small-molecule biomarkers of drug resistance. UHPLC-triple quadrupole MS operated in multiple reaction monitoring mode was used for quantitative analysis of metabolic features from UHPLC-TOF/MS profiling. Up to 41 differential metabolites involved in glycerophospholipid metabolism, sphingolipid metabolism, and fatty acid metabolism were observed in a chloramphenicol-resistant mutant strain of Campylobacter jejuni. A panel of 40 features was identified in florfenicol-resistant mutants, demonstrating changes in glycerophospholipid metabolism, sphingolipid metabolism, and tryptophan metabolism. This study shows that the UHPLC-MS-based metabolomics platform is a promising and valuable tool to generate new insights into the drug-resistant mechanism of Campylobacter jejuni.

  16. Effect of feeding Aspergillus awamori and canola seed on the growth performance and muscle fatty acid profile in broiler chicken.

    Science.gov (United States)

    Saleh, Ahmed A; Hayashi, Kunioki; Ijiri, Daichi; Ohtsuka, Akira

    2015-03-01

    The aim of this study was to examine effects of dietary supplementation with Aspergillus awamori and feeding canola seed on the growth and fatty acid profile in broilers. Twenty-eight chicks (15 days old) were assigned to the following groups: (1) control, fed a basal diet; (2) awamori, fed the basal diet supplemented with 0.05% A. awamori; (3) canola, fed a diet containing 5% canola seed; and (4) canola + awamori, fed the canola diet supplemented with A. awamori (seven birds/group). Body weight gain was increased by A. awamori but not influenced by canola seed. Breast muscle weight was increased in either awamori or canola groups. Although plasma triglyceride and cholesterol were decreased by feeding A. awamori or canola seed, fat content in the breast muscle were increased, accompanied by decrease in saturated fatty acids and increase in unsaturated fatty acids. Moreover, decreased thiobarbituric acid reactive substance and increased α-tocopherol content in the breast muscle was observed in all experimental groups. In conclusion, these results suggested that feeding canola seed and A. awamori might improve growth performance, and modified muscle fatty acid profile and α-tocopherol content, suggesting that they may improve meat quality. © 2014 Japanese Society of Animal Science.

  17. Use of speed profile as surrogate measure: Effect of traffic calming devices on crosstown road safety performance.

    Science.gov (United States)

    Moreno, Ana Tsui; García, Alfredo

    2013-12-01

    Urban road safety management is usually characterized by the lack of sufficient, good quality crash data and low budgets to obtain it even though many traffic accidents occur there. For example, 54 percent of road crashes in Spain take place in urban areas, and 10 percent of urban fatal crashes occur on crosstown roads, which are rural roads that traverse small communities. Traffic calming measures (TCMs) are often implemented on these parts of rural roads that traverse small communities in order to reduce both the frequency and severity of crashes by lowering speeds, but evaluation of their effectiveness has been limited. The objective of this study was to develop a methodology using continuous speed profiles to evaluate the safety effectiveness of TCMs on crosstown roads as part of an integrated system in the absence of historical data. Given the strong relationship between speed and crash experience, safety performance can be related to speed. Consequently, speed can be used indirectly as a surrogate safety measure in the absence of crash and speed data. Two indexes were defined in this study as surrogate safety measures based on the continuous speed profile: Ra and Ea. Ra represents the absolute accumulated speed variations relative to the average speed and is inversely related to accumulated speed uniformity; and Ea represents the accumulated speed variations above the speed limit and is directly related to accumulated speeding. Naturalistic data were collected using GPS trackers for 12 scenarios with different TCM spacings. Then, the indexes were applied to individual observed speed profiles (individual analysis) as well as the operating speed profile (global analysis). The values obtained from individual and global analysis were statistically different. Spacing lower than 110m, which was found optimal from previous research, did not allow drivers to modify their speeds as the accumulated speed uniformity was quite similar regardless of the average operating

  18. Anthropometric profile and physical performance characteristic of the Brazilian amputee football (soccer team

    Directory of Open Access Journals (Sweden)

    Mário A. M. Simim

    2013-09-01

    Full Text Available Amputee football is a variation of conventional soccer in which athletes with lower limb amputation and one athelete with upper limb amputation (the goalkeeper participate. The objective of this study was to investigate the anthropometric and physical characteristics of amputee football athletes and to verify differences between heart rate peak (HRpeak and equations for predicting maximum heart rate (HRmax. Twelve amputee soccer players from the Brazilian team participated in this study. The body mass, height and body composition were measured. The physical tests used were: the 20 m running test, the T-square test and the Yo Yo intermitent recovery test - level 1 (YYIRT1. The percentage of fat was significantly different between midfielders and defenders. No significant differences were found between positions in the physical tests. The HRpeak was significantly lower than all of HRmax prediction equations tested. We conclude that the indicators of physical performance did not differ significantly between the different tactics roles of players, and that, after intermittent maximum effort, the cardiac response was lower when compared with the investigated HRmax prediction equations.

  19. GAME LOCATION AND TEAM QUALITY EFFECTS ON PERFORMANCE PROFILES IN PROFESSIONAL SOCCER

    Directory of Open Access Journals (Sweden)

    Carlos Lago-Peñas

    2011-09-01

    Full Text Available Home advantage in team sports has an important role in determining the outcome of a game. The aim of the present study was to identify the soccer game- related statistics that best discriminate home and visiting teams according to the team quality. The sample included all 380 games of the Spanish professional men's league. The independent variables were game location (home or away and the team quality. Teams were classified into four groups according to their final ranking at the end of the league. The game-related statistics registered were divided into three groups: (i variables related to goals scored; (ii variables related to offense and (iii variables related to defense. A univariate (t-test and Mann-Whitney U and multivariate (discriminant analysis analysis of data was done. Results showed that home teams have significantly higher means for goal scored, total shots, shots on goal, attacking moves, box moves, crosses, offsides committed, assists, passes made, successful passes, dribbles made, successful dribbles, ball possession, and gains of possession, while visiting teams presented higher means for losses of possession and yellow cards. In addition, the findings of the current study confirm that game location and team quality are important in determining technical and tactical performances in matches. Teams described as superior and those described as inferior did not experience the same home advantage. Future research should consider the influence of other confounding variables such as weather conditions, game status and team form

  20. Performance profile of NCAA Division I men's basketball games and training sessions.

    Science.gov (United States)

    Conte, D; Tessitore, A; Smiley, K; Thomas, C; Favero, T G

    2016-06-01

    This study aimed to analyse live and stoppage time phases, their ratio, and action played on half and full court in college basketball games. Differences were assessed for the entire games and between halves. Moreover, differences of the live/stoppage time ratio were analysed between games and game-based conditioning drills. Ten games as well as fifteen defensive, fourteen offensive and six scrimmage-type drills of the same division I men's college team (13 players) were analysed using time-motion analysis technique. Live and stoppage time were classified in five classes of duration: 1-20, 21-40, 41-60, 61-80, >80 seconds. Half court actions started and finished in the same half court. Full court actions were classified as transfer (TR) phases when at least 3 teammates crossed the mid-court line. TR phases were then classified in 5 classes of frequency: 1TR, 2TR, 3TR, 4TR, and >4TR. The results revealed no statistically significant differences between games or between halves for the considered parameters. The only significant difference was observed for live/stoppage time ratio between halves (pgames and game-based drills (pgames, and defensive and offensive drills (pgames in the analysed parameters might be important to characterize the model of performance in division I men's college games. Furthermore, these results encourage coaches to use game-based conditioning drills to replicate the LT/ST ratio documented during games.

  1. Energy, Environmental and Economic Performance of a Micro-trigeneration System upon Varying the Electric Vehicle Charging Profiles

    Directory of Open Access Journals (Sweden)

    Sergio Sibilio

    2017-09-01

    Full Text Available The widespread adoption of electric vehicles and electric heat pumps would result in radically different household electrical demand characteristics, while also possibly posing a threat to the stability of the electrical grid. In this paper, a micro-trigeneration system (composed of a 6.0 kWel cogeneration device feeding a 4.5 kWcool electric air-cooled vapor compression water chiller serving an Italian residential multi-family house was investigated by using the dynamic simulation software TRNSYS. The charging of an electric vehicle was considered by analyzing a set of seven electric vehicle charging profiles representing different scenarios. The simulations were performed in order to evaluate the capability of micro-cogeneration technology in: alleviating the impact on the electric infrastructure (a; saving primary energy (b; reducing the carbon dioxide equivalent emissions (c and determining the operating costs in comparison to a conventional supply system based on separate energy production (d.

  2. Diagnostic Performance of Plasma DNA Methylation Profiles in Lung Cancer, Pulmonary Fibrosis and COPD.

    Science.gov (United States)

    Wielscher, Matthias; Vierlinger, Klemens; Kegler, Ulrike; Ziesche, Rolf; Gsur, Andrea; Weinhäusel, Andreas

    2015-08-01

    Disease-specific alterations of the cell-free DNA methylation status are frequently found in serum samples and are currently considered to be suitable biomarkers. Candidate markers were identified by bisulfite conversion-based genome-wide methylation screening of lung tissue from lung cancer, fibrotic ILD, and COPD. cfDNA from 400 μl serum (n = 204) served to test the diagnostic performance of these markers. Following methylation-sensitive restriction enzyme digestion and enrichment of methylated DNA via targeted amplification (multiplexed MSRE enrichment), a total of 96 markers were addressed by highly parallel qPCR. Lung cancer was efficiently separated from non-cancer and controls with a sensitivity of 87.8%, (95%CI: 0.67-0.97) and specificity 90.2%, (95%CI: 0.65-0.98). Cancer was distinguished from ILD with a specificity of 88%, (95%CI: 0.57-1), and COPD from cancer with a specificity of 88% (95%CI: 0.64-0.97). Separation of ILD from COPD and controls was possible with a sensitivity of 63.1% (95%CI: 0.4-0.78) and a specificity of 70% (95%CI: 0.54-0.81). The results were confirmed using an independent sample set (n = 46) by use of the four top markers discovered in the study (HOXD10, PAX9, PTPRN2, and STAG3) yielding an AUC of 0.85 (95%CI: 0.72-0.95). This technique was capable of distinguishing interrelated complex pulmonary diseases suggesting that multiplexed MSRE enrichment might be useful for simple and reliable diagnosis of diverse multifactorial disease states.

  3. Performance profile of NCAA Division I men’s basketball games and training sessions

    Directory of Open Access Journals (Sweden)

    D Conte

    2016-05-01

    Full Text Available This study aimed to analyse live and stoppage time phases, their ratio, and action played on half and full court in college basketball games. Differences were assessed for the entire games and between halves. Moreover, differences of the live/stoppage time ratio were analysed between games and game-based conditioning drills. Ten games as well as fifteen defensive, fourteen offensive and six scrimmage-type drills of the same division I men’s college team (13 players were analysed using time-motion analysis technique. Live and stoppage time were classified in five classes of duration: 1-20, 21-40, 41-60, 61-80, >80 seconds. Half court actions started and finished in the same half court. Full court actions were classified as transfer (TR phases when at least 3 teammates crossed the mid-court line. TR phases were then classified in 5 classes of frequency: 1TR, 2TR, 3TR, 4TR, and >4TR. The results revealed no statistically significant differences between games or between halves for the considered parameters. The only significant difference was observed for live/stoppage time ratio between halves (p<0.001. Furthermore, a significant difference of the live/stoppage ratio was found between games and game-based drills (p<0.01. Post-hoc analysis demonstrated significant differences of scrimmage-type drills in comparison to games, and defensive and offensive drills (p<0.05, whereas no differences emerged for the other pairwise comparisons. The absence of differences between games in the analysed parameters might be important to characterize the model of performance in division I men’s college games. Furthermore, these results encourage coaches to use game-based conditioning drills to replicate the LT/ST ratio documented during games.

  4. Effect of squash seed meal (Cucurbita moschata on broiler performance, sensory meat quality, and blood lipid profile

    Directory of Open Access Journals (Sweden)

    YM Aguilar

    2011-12-01

    Full Text Available In this experiment, 240 Cobb-500® broilers reared from1 to 49 days, and distributed according to a completely experimental randomized design with four treatments of four replicates each in order to evaluate the effect of the dietary inclusion of 0, 33, 66 or 100 g/kg of squash seed meal (SSM (Cucurbita moschata on the performance, carcass yield, serum lipid profile and sensory meat quality of broilers. Significant differences (p<0.05 were detected in performance, carcass weight, weight and breast yield, and leg weight. The best results were obtained with 33 and 66 g/kg as compared to the control diet and 100 g SSM /kg. Abdominal fat decreased with the inclusion of 66 and 100 g SSM / kg, but the sensory quality of breast and thighs was not affected by the inclusion of SSM. The serum levels of total cholesterol, very low density (VLDL and low density (LDL lipoproteins, triglycerides, glucose and atherogenic index decreased with the inclusion of 100 g/kg of SSM, except for high density lipoproteins (HDL, which increased. The inclusion of 0, 33, 66 and 100 g/kg of SSM in broiler diets, partially replacing soybean meal and vegetable oil, improved live performance and edible portions yield. In addition, abdominal fat and serum levels of harmful lipids were reduced, whereas serum levels of beneficial lipids increased. There was no effect on meat sensory quality.

  5. The effects of tapering on power-force-velocity profiling and jump performance in professional rugby league players.

    Science.gov (United States)

    de Lacey, James; Brughelli, Matt; McGuigan, Michael; Hansen, Keir; Samozino, Pierre; Morin, Jean-Benoit

    2014-12-01

    The purpose of this study was to investigate the effects of a preseason taper on individual power-force-velocity profiles and jump performance in professional National Rugby League players. Seven professional rugby league players performed concentric squat jumps using ascending loads of 25, 50, 75, 100% body mass before and after a 21-day step taper leading into the in-season. Linear force-velocity relationships were derived, and the following variables were obtained: maximum theoretical velocity (V0), maximum theoretical force (F0), and maximum power (Pmax). The players showed likely-to-very likely increases in F0 (effect size [ES] = 0.45) and Pmax (ES = 0.85) from pre to posttaper. Loaded squat jump height also showed likely-to-most likely increases at each load (ES = 0.83-1.04). The 21-day taper was effective at enhancing maximal power output and jump height performance in professional rugby players, possibly as a result of a recovery from fatigue and thus increased strength capability after a prolonged preseason training period. Rugby league strength and conditioning coaches should consider reducing training volume while maintaining intensity and aerobic conditioning (e.g., step taper) leading into the in-season.

  6. Improvement of Nannochloropsis oceanica growth performance through chemical mutation and characterization of fast growth physiology by transcriptome profiling

    Science.gov (United States)

    Liang, Sijie; Guo, Li; Lin, Genmei; Zhang, Zhongyi; Ding, Haiyan; Wang, Yamei; Yang, Guanpin

    2016-09-01

    Nannochloropsis oceanica promises to be an industrial-level producer of polyunsaturated fatty acids. In this study, the fastest and slowest growing N. oceanica mutants were selected through N-methyl-N'-nitro-N-nitrosoguanidine mutation, and two mutant strains and the wild type (WT) subjected to transcriptome profiling. It was found that the OD680 reads at stationary growth phase of both WT and its mutants were proportional to their cell density, thus indicating their division rate and growth speed during culture. This chemical mutation was effective for improving growth performance, and the fast strain divided faster by upregulating the expression of genes functioning in the cell cycle and downregulating genes involved in synthesis of amino acids, fatty acids, and sugars as well as the construction of ribosome and photosynthetic machinery. However, the relationship among the effected genes responsible for cell cycle, metabolism of fatty and amino acids, and construction of ribosome and photosynthetic machinery remained unclear. Further genetic studies are required for clarifying the genetic/metabolic networks underpinning the growth performance of N. oceanica. These findings demonstrated that this mutation strategy was effective for improving the growth performance of this species and explored a means of microalgal genetic improvement, particularly in species possessing a monoploid nucleus and asexual reproduction.

  7. Improvement of Nannochloropsis oceanica growth performance through chemical mutation and characterization of fast growth physiology by transcriptome profiling

    Science.gov (United States)

    Liang, Sijie; Guo, Li; Lin, Genmei; Zhang, Zhongyi; Ding, Haiyan; Wang, Yamei; Yang, Guanpin

    2017-07-01

    Nannochloropsis oceanica promises to be an industrial-level producer of polyunsaturated fatty acids. In this study, the fastest and slowest growing N. oceanica mutants were selected through N-methyl-N'-nitro-N-nitrosoguanidine mutation, and two mutant strains and the wild type (WT) subjected to transcriptome profiling. It was found that the OD680 reads at stationary growth phase of both WT and its mutants were proportional to their cell density, thus indicating their division rate and growth speed during culture. This chemical mutation was effective for improving growth performance, and the fast strain divided faster by upregulating the expression of genes functioning in the cell cycle and downregulating genes involved in synthesis of amino acids, fatty acids, and sugars as well as the construction of ribosome and photosynthetic machinery. However, the relationship among the effected genes responsible for cell cycle, metabolism of fatty and amino acids, and construction of ribosome and photosynthetic machinery remained unclear. Further genetic studies are required for clarifying the genetic/metabolic networks underpinning the growth performance of N. oceanica. These findings demonstrated that this mutation strategy was effective for improving the growth performance of this species and explored a means of microalgal genetic improvement, particularly in species possessing a monoploid nucleus and asexual reproduction.

  8. Effect of synbiotic supplementation and dietary fat sources on broiler performance, serum lipids, muscle fatty acid profile and meat quality.

    Science.gov (United States)

    Ghasemi, H A; Shivazad, M; Mirzapour Rezaei, S S; Karimi Torshizi, M A

    2016-01-01

    A 42-d trial was conducted to investigate the effect of adding a synbiotic supplement to diets containing two different types of fat on performance, blood lipids and fatty acid (FA) composition and oxidative stability of breast and thigh meat in broilers. A total of 800 one-d-old male broiler chickens were randomly assigned into 1 of 8 treatments with 4 replicates of 25 birds per treatment. The experiment consisted of a 4 × 2 factorial arrangement of treatments including 4 concentrations of synbiotic (0, 0.5, 1 or 1.5 g/kg diet) and 2 types of fat [sunflower oil (SO) or canola oil (CO)] at an inclusion rate of 50 g/kg diet. Dietary fat type did not affect body weight gain (BWG) or feed conversion ratio (FCR) during the overall experimental period (0-42 d). However, fat type modified serum lipid profile and FA composition and 2-thiobarbituric acid-reactive substances (TBARS) content in breast and thigh meat. The addition of synbiotic to the diet linearly improved overall BWG and FCR and also decreased serum cholesterol and low-density lipoprotein cholesterol concentrations. The TBARS value in thigh meat after 30 d of storage at 4°C was linearly decreased as the synbiotic inclusion concentrations in the diets increased. Dietary synbiotic also decreased the proportion of monounsaturated fatty acids and increased n-6 polyunsaturated fatty acid (PUFA) concentration in thigh meat, whereas the FA profile of breast meat was not affected by synbiotic supplementation. Moreover, the PUFA/SFA ratio in the breast meat was linearly increased when synbiotic was included in the CO-containing diets. In conclusion, the addition of synbiotic to broiler diets had a positive effect on growth performance, blood lipid profile and meat quality. The results also support the use of synbiotic to increase the capacity of canola oil for enhancing PUFA/SFA ratio of breast meat in broilers.

  9. The Effect of Electric Load Profiles on the Performance of Off-Grid Residential Hybrid Renewable Energy Systems

    Directory of Open Access Journals (Sweden)

    Stephen Treado

    2015-10-01

    Full Text Available This paper investigates the energy performance of off-grid residential hybrid renewable electric power systems, particularly the effect of electric load profiles on the ability to harvest available solar energy and avoid the consumption of auxiliary energy in the form of propane. The concepts are illustrated by an analysis of the energy performance of electric and propane-fired refrigerators. Off-grid electric power systems frequently incorporate a renewable source, such as wind or solar photovoltaic (PV, with a back-up power provided by a propane fueled motor/generator. Among other design decisions, residential consumers face the choice of employing an electric refrigerator with a conventional vapor compression refrigeration system, or a fuel-fired refrigerator operating as an absorption refrigeration system. One interesting question is whether it is more advantageous from an energy perspective to use electricity to run the refrigerator, which might be provided by some combination of the PV and propane motor/generator, thereby taking advantage of the relatively higher electric refrigerator Coefficient of Performance (COP and free solar energy but having to accept a low electrical conversion efficiency of the motor/generator, or use thermal energy from the combustion of propane to produce the refrigeration effect via an absorption system, albeit with a much lower COP. The analysis is complicated by the fact that most off-grid renewable electrical power systems utilize a battery bank to provide electrical power when it is not available from the wind turbine or PV system, so the state of charge of the battery bank will have a noticeable impact on what energy source is available at any moment in time. Daily electric load profiles combined with variable solar energy input determine the state of charge of the battery bank, with the degree of synchronization between the two being a critical factor in determining performance. The annual energy usage

  10. Monitoring performance, pituitary-adrenal hormones and mood profiles : how to diagnose non-functional over-reaching in male elite junior soccer players

    NARCIS (Netherlands)

    Schmikli, Sandor L.; de Vries, Wouter R.; Brink, Michel S.; Backx, Frank J. G.

    2012-01-01

    Objective To verify if in male elite junior soccer players a minimum 1-month performance decrease is accompanied by a mood profile and hormone levels typical of non-functional over-reaching (NFOR). Design A prospective case-control study using a monthly performance monitor with a standardised field

  11. Chemical and Metabolic Profiling of Si-Ni Decoction Analogous Formulae by High performance Liquid Chromatography-Mass Spectrometry

    Science.gov (United States)

    Chen, Qian; Xiao, Shun; Li, Zhenhao; Ai, Ni; Fan, Xiaohui

    2015-01-01

    Along with an indispensable role in healthcare system of China for centuries, Traditional Chinese Medicine (TCM) shows increasing usages as complementary therapy in western countries. To improve our understanding on their therapeutic effects, it’s critical to unveil chemical compositions of TCM formula, the predominant form of therapy in TCM. However, intrinsic chemical complexity makes it a challenging task to perform analysis on each individual TCM formula even with most current state-of-art analytic techniques available. In this work we approached this question by focusing on analogous formulae, a unique category of TCM formulae grouped together based on shared herbs and/or similar TCM syndromes. Systematic chemical profiling on five Si-Ni decoctions (SNs) for cardiovascular diseases was performed by multistage MS and high-resolution MS (HR-MS) experiments. A total of 83 compounds, including alkaloids, flavonoids, ginsenosides, bile acids and triterpenoids, were described. Analysis on SNs-treated rats detected 55 prototype compounds and 39 metabolites in the systemic circulation in vivo, which may contribute directly to their observed clinical efficacies. This approach offers great advantage to speed up identification of chemical compositions of formula and reveal the difference among these analogous formulae that may be related to diverse clinical effects. PMID:26118924

  12. Development of a high-performance gantry system for a new generation of optical slope measuring profilers

    Energy Technology Data Exchange (ETDEWEB)

    Assoufid, Lahsen, E-mail: assoufid@aps.anl.gov [Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439 (United States); Brown, Nathan; Crews, Dan [ALIO Industries, 11919 I-70 Frontage Road N, Unit 119, Wheat Ridge, CO 80033 (United States); Sullivan, Joseph; Erdmann, Mark; Qian, Jun; Jemian, Pete [Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439 (United States); Yashchuk, Valeriy V. [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Takacs, Peter Z. [Brookhaven National Laboratory, Upton, NY 11973 (United States); Artemiev, Nikolay A.; Merthe, Daniel J.; McKinney, Wayne R. [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Siewert, Frank; Zeschke, Thomas [Helmholtz Zentrum Berlin/ BESSY-II, Institut für Nanometer Optik und Technologie, Albert-Einstein-Strasse 15 12489 Berlin (Germany)

    2013-05-11

    A new high-performance metrology gantry system has been developed within the scope of collaborative efforts of optics groups at the US Department of Energy synchrotron radiation facilities as well as the BESSY-II synchrotron at the Helmholtz Zentrum Berlin (Germany) and the participation of industrial vendors of x-ray optics and metrology instrumentation directed to create a new generation of optical slope measuring systems (OSMS) [1]. The slope measurement accuracy of the OSMS is expected to be <50 nrad, which is strongly required for the current and future metrology of x-ray optics for the next generation of light sources. The fabricated system was installed and commissioned (December 2012) at the Advanced Photon Source (APS) at Argonne National Laboratory to replace the aging APS Long Trace Profiler (APS LTP-II). Preliminary tests were conducted (in January and May 2012) using the optical system configuration of the Nanometer Optical Component Measuring Machine (NOM) developed at Helmholtz Zentrum Berlin (HZB)/BESSY-II. With a flat Si mirror that is 350 mm long and has 200 nrad rms nominal slope error over a useful length of 300 mm, the system provides a repeatability of about 53 nrad. This value corresponds to the design performance of 50 nrad rms accuracy for inspection of ultra-precise flat optics.

  13. Performance Enhancement and Immunity Profile of Broiler Treated Feed Additive Containing Lactic Acid Bacteria and Ganoderma lucidum

    Directory of Open Access Journals (Sweden)

    A. Sofyan

    2012-12-01

    Full Text Available The experiment was conducted to evaluate the influence of feed additive containing lactic acid bacteria (LAB and Ganoderma lucidum (GL on body weight gain (BWG, feed efficiency (FE, performance index (PI, antibody titer (AT against Newcastle disease and histopathology of broilers. Bacteria used were Lactobacillus salivarius and Pediococcus pentosaceus, which were isolated from broiler’s intestine. A number of 195 unsexed day old chicks (Cobb strain were arranged in a completely randomized design and consisted of 5 treatments, each in 3 equal replicates. The treatments were as followed T0: control/without-feed additive, T1: 1% LAB (109 cfu g-1, T2: 1% GL, T3: 1% of LAB 109 cfu g-1 + GL (1:1, T4: commercial antibiotic. Data were analyzed using ANOVA and conti-nued to Duncan’s multiple range test. The results showed that T2, T3, T4 treatments significantly improved (P<0.05 BWG, FE and PI of broilers. Broilers fed T3 had the highest PI, followed by T4, T1, T2 and T0. Broilers fed T3 had the highest AT value followed by T0, T2, T4, and T1. Histopathology profile showed that broiler fed T3 had no lesion on liver and intestine compared to others. The result of this experiment indicated that additive containing 0.25% L. salivarius, 0.25% P. pentosaceus, and 0.5% G. lucidum was able to enhance broiler performance.

  14. Monitoring gradient profile on-line in micro- and nano-high performance liquid chromatography using conductivity detection.

    Science.gov (United States)

    Zhang, Min; Chen, Apeng; Lu, Joann J; Cao, Chengxi; Liu, Shaorong

    2016-08-19

    In micro- or nano-flow high performance liquid chromatography (HPLC), flow-splitters and gradient elutions are commonly used for reverse phase HPLC separations. When a flow splitter was used at a high split-ratio (e.g., 1000:1 or higher), the actual gradient may deviate away from the programmed gradient. Sometimes, mobile phase concentrations can deviate by as much as 5%. In this work, we noticed that the conductivity (σ) of a gradient decreased with the increasing organic-solvent fraction (φ). Based on the relationship between σ and φ, a method was developed for monitoring gradient profile on-line to record any deviations in these HPLC systems. The conductivity could be measured by a traditional conductivity detector or a capacitively coupled contactless conductivity detector (C(4)D). The method was applied for assessing the performance of an electroosmotic pump (EOP) based nano-HPLC. We also observed that σ value of the gradient changed with system pressure; a=0.0175ΔP (R(2)=0.964), where a is the percentage of the conductivity increase and ΔP is the system pressure in bar. This effect was also investigated.

  15. High-performance liquid chromatography-mass spectrometry profiling of phenolic compounds for evaluation of olive oil bitterness and pungency.

    Science.gov (United States)

    Dierkes, Georg; Krieger, Sonja; Dück, Roman; Bongartz, Annette; Schmitz, Oliver J; Hayen, Heiko

    2012-08-08

    Bitterness and pungency are important parameters for olive oil quality. Therefore, two instrumental methods for evaluation of these taste attributes were developed. The first one is based on the photometric measurement of total phenolic compounds content, whereas the second one is based on the semiquantitative evaluation of hydrophilic compounds by high-performance liquid chromatography-mass spectrometry (HPLC-MS). Evaluation of total phenolic compounds content was performed by a modified method for the determination of the K(225) value using a more specific detection based on the pH value dependency of absorbance coefficients of phenols at λ = 274 nm. The latter method was not suitable for correct prediction, because no significant correlation between bitterness/pungency and total phenolic compounds content could be found. For the second method, areas of 25 peaks detected in 54 olive oil samples by a HPLC-MS profiling method were correlated with the bitterness and pungency by partial least-squares regression. Six compounds (oleuropein aglycon, ligstroside aglycon, decarboxymethyl oleuropein aglycon, decarboxymethyl ligstroside aglycon, elenolic acid, and elenolic acid methyl ester) show high correlations to bitterness and pungency. The computed model using these six compounds was able to predict bitterness and pungency of olive oil in the error margin of the sensory evaluation (±0.5) for most of the samples.

  16. Phytochemical profile and nutraceutical potential of chia seeds (Salvia hispanica L.) by ultra high performance liquid chromatography.

    Science.gov (United States)

    Martínez-Cruz, Oliviert; Paredes-López, Octavio

    2014-06-13

    Chia seeds (Salvia hispanica) were analyzed for total phenolic compounds, antioxidant activity, and quantification of phenolic acids and isoflavones by ultra high performance liquid chromatography (UHPLC), in order to obtain a phenolic phytochemical profile. The total phenolic concentration was 1.8-fold higher than previous reports and the antioxidant activity using DPPH (2,2-diphenyl-1-picrylhydrazyl) radical assay showed 68.83% inhibition, which was higher than the values reported previously for chia and different plant foods. Additionally, a simple, reproducible and rapid UHPLC method was proposed for the analysis of phenolic acids and isoflavones in chia. The method demonstrated to perform well with regard to linearity, limits of detection and quantification, precision, accuracy, and sensitivity. The detection limits ranged from 0.05 to 0.4ng/mL and the recovery percentage from 23.62 to 162.48%. With this method the major compounds identified and quantified were: rosmarinic acid 0.92, protocatechuic ethyl ester 0.74, caffeic acid 0.02, gallic acid 0.01, and daidzin 0.006mg/g seed. In brief, this study demonstrates that chia could be considered a seed with high antioxidant capacity and novel isoflavone source that can be incorporated in human diet.

  17. Effect of balanced concentrate ration on the performance and hematobiochemical profile of lactating native ewes and lambs in coastal Odisha

    Directory of Open Access Journals (Sweden)

    Sasanka Sekhar Beura

    2014-12-01

    Full Text Available Aim: The present study was conducted to evaluate the effect of supplementation of balanced concentrate ration during lactation on the growth performance, blood and metabolic profiles of native ewes and lambs in coastal Odisha. Materials and Methods: A total of 40 numbers of lactating ewes of the same parity comprised the experimental animals. The selected ewes were randomly assigned to two groups of twenty each, maintaining uniformity in body weight (13.36±0.33 kg for Group 1 and 13.48±0.37 kg for Group 2. Group 1 was maintained on grazing only while Group 2 was supplemented with a balanced concentrate mixture @ 200 g/head/day during the first 2 months of lactation. The concentrate was fed individually in separate containers in the morning hours before the animals were taken out for grazing. Results: The ewes in Group 2 registered higher body weights at every fortnight. The differences were found to be highly significant (p<0.01 from 2nd to 5th fortnight and significant (p<0.05 for the remaining fortnights. The ewes in Group 2 showed significantly (p<0.01 higher daily gains than those in Group 1 at every fortnight. The hemoglobin (Hb concentration, mean cell hemoglobin (MCH and total leukocyte count (TLC values were significant (p<0.05 between groups at the end of 4th fortnight after lambing and the mean cell hemoglobin concentration (MCHC values is significantly (p<0.05 higher in Group 2 over Group 1. Conclusion: It was concluded that supplementation of a balanced concentrate mixture (crude protein 18.21% @ 200 g/ewe/day along with grazing during the first 2 months of lactation resulted in higher ewe body weight gain. It improved their hematological and metabolic profiles and also resulted in higher body weight gain in lambs born to these supplemented ewes.

  18. Effect of Sapindus rarak powder as feed additive on performance and lipid profile of broiler chicken infected by Eimeria tenella

    Directory of Open Access Journals (Sweden)

    Tiurma Pasaribu

    2014-12-01

    Full Text Available Sapindus rarak fruits have bioactive compound named saponin which are potential to inhibit growth of protozoa and reduce cholesterol. This study was conducted to evaluate effect of lerak (Sapindus rarak powder as microparticle on performance and lipid profile of chicken broiler that was infected by Eimeria tenella. A total of150headsof DOCwere assign to recive on of5 treatments: T1 (K+, TAk, TSRa, TIE, T2 (K-, TAk, TSRa, IE, T3 (Sal, IE, T4 (Sra 2,5, IE, and T5 (Sra 1,25, IE; each treatment consisted of 6replications with 5birds per replications in battery cage for 34 days. All chickens except those in control positive treatment (non-infected, non-medicated were inoculated orally with 6000 oocysts E. tenella on the 14th day of age. Variables measured were body weight gain, carcass, OPG (oocysts pergram of faeces, lipid profile, and mortality. Treatment with S. rarak, dose of 1.25g/kg was not significantly different from the salinomycin treatment on BWG and feed conversion. Percentage of carcassand organs and blood cholesterol concentration were not significantly differentin all treatments, but blood triglyceride at S. rarak addition with doseof 2.5, 1.25g/kg and salinomycin addition with dose of 0.5g/kg, and negative control were lower than positive control. While number of OPG in faeces (days 14-34 showed that S. rarak powder with dose of 2.5 and 1.25g/kg suppressed the development of oocystsof E. tenella. In conclusion, S. rarak microparticle (75µm can be used as feed additive to replace salinomycinas coccidiostat.

  19. Candidates Profile in FUVEST Exams from 2004 to 2013: Private and Public School Distribution, FUVEST Average Performance and Chemical Equilibrium Tasks Performance

    Directory of Open Access Journals (Sweden)

    R.S.A.P. Oliveira

    2014-08-01

    Full Text Available INTRODUCTION. Chemical equilibrium is recognized as a topic of several misconceptions. Its origins must be tracked from previous scholarship. Its impact on biochemistry learning is not fully described. A possible bulk of data is the FUVEST exam. OBJECTIVES: Identify students’ errors profile on chemical equilibrium tasks using public data from FUVEST exam. MATERIAL AND METHODS: Data analysis from FUVEST were: i Private and Public school distribution in Elementary and Middle School, and High School candidates of Pharmacy-Biochemistry course and total USP careers until the last call for enrollment (2004-2013; ii Average performance in 1st and 2nd parts of FUVEST exam of Pharmacy-Biochemistry, Chemistry, Engineering, Biological Sciences, Languages and Medicine courses and total enrolled candidates until 1st call for enrollment (2008- 2013; iii Performance of candidates of Pharmacy-Biochemistry, Chemistry, Engineering, Biological Sciences, Languages and Medicine courses and total USP careers in chemical equilibrium issues from 1st part of FUVEST (2011-2013. RESULTS AND DISCUSSION: i 66.2% of candidates came from private Elementary-Middle School courses and 71.8%, came from High School courses; ii Average grade over the period for 1st and 2nd FUVEST parts are respectively (in 100 points: Pharmacy-Biochemistry 66.7 and 61.2, Chemistry 65.9 and 58.9, Engineering 75.9 and 71.9, Biological Sciences 65.6 and 54.6, Languages 49.9 and 43.3, Medicine 83.5 and 79.5, total enrolled candidates 51,5 and 48.9; iii Four chemical equilibrium issues were found during 2011-2013 and the analysis of multiplechoice percentage distribution over the courses showed that there was a similar performance of students among them, except for Engineering and Medicine with higher grades, but the same proportional distribution among choices. CONCLUSION: Approved students came majorly from private schools. There was a different average performance among courses and similar on

  20. Supramaximal intermittent running performance in relation to age and locomotor profile in highly-trained young soccer players.

    Science.gov (United States)

    Buchheit, Martin; Mendez-Villanueva, Alberto

    2013-01-01

    The aim of the study was to examine supramaximal intermittent running performance in highly-trained young soccer players, with regard to age and locomotor profile. Twenty-seven Under 14, 19 U16 and 16 U18 highly-trained soccer players performed an incremental intermittent running test (30-15 Intermittent Fitness Test) to assess supramaximal intermittent running performance (VIFT), an incremental running test to estimate maximal aerobic speed (VVam-Eval) and a 40-m sprint to estimate maximal sprinting speed (MSS). U16 and U18 presented very likely greater VIFT (19.2 ± 0.9, 19.7 ± 1.0 vs. 17.4 ± 0.9 km · h(-1)) and VVam-Eval (16.2 ± 0.9, 16.7 ± 1.0 vs. 14.6 ± 0.9 km · h(-1)) than U14, while there was no clear difference between U16 and U18. MSS (25.1 ± 1.6, 29.3 ± 1.6 and 31.0 ± 1.1 km · h(-1) for U14, U16 and U18) was very likely different between all groups. When data were pooled together, VIFT was very largely correlated with VVam-Eval and MSS (overall r =0.89, partial r = 0.74 and 0.29, respectively). Within-age group correlations showed that the older the players, the greater the magnitude of the correlations between VIFT and VVam-Eval (r = 0.67, 0.73 and 0.87). In conclusion, the major predictors of VIFT were, in order of importance, VVam-Eval and MSS; however, the older the players, the greater the correlations with VVam-Eval.

  1. Athletic performance outcomes following lumbar discectomy in professional basketball players.

    Science.gov (United States)

    Anakwenze, Okechukwu A; Namdari, Surena; Auerbach, Joshua D; Baldwin, Keith; Weidner, Zachary D; Lonner, Baron S; Huffman, G R; Sennett, Brian J

    2010-04-01

    Retrospective case-control study. To quantify the athletic performance profiles after lumbar discectomy (LD) in a cohort of National Basketball Association (NBA) players in comparison with a control group of matched NBA players who did not undergo LD during the same study period. LD provides symptomatic relief and improved functional outcomes in the majority of patients as assessed by validated measures such as Oswestry Disability Index, Visual Analog Scale, and Short Form-36 (SF-36). Among professional athletes, however, the goal of lumbar HNP treated by discectomy is not only to improve functional status but also, ultimately, to return the player to preinjury athletic performance levels. No study to date has compared the athletic performance profiles before and after discectomy in professional athletes. An analysis of NBA games summaries, weekly injury reports, player profiles, and press releases was performed to identify 24 NBA players who underwent LD for symptomatic lumbar HNP between 1991 and 2007. A 1:2 case: control study was performed using players without history of lumbar HNP who were matched for age, position, experience, and body mass index as control subjects (n = 48). Paired t tests were conducted on the following parameters: games played, minutes per game, points per 40 minutes, rebounds per 40 minutes, assists per 40 minutes, steals per 40 minutes, blocks per 40 minutes, and shooting percentage. For each athletic performance outcome, between-group comparisons evaluating preindex to postindex season performance were done (index season = season of surgery). In the LD group, 18 of 24 players (75%) returned to play again in the NBA, compared with 42 of 48 players (88%, P = 0.31) in the control group. One year after surgery, between-group comparisons revealed statistically significant increase in blocked shots per 40 minutes in the LD (0.18) versus control group (-0.33; P = 0.008) and a smaller decrease in rebounds per 40 minutes in the LD (-0

  2. Experimental Study of the Flexural and Compression Performance of an Innovative Pultruded Glass-Fiber-Reinforced Polymer-Wood Composite Profile.

    Science.gov (United States)

    Qi, Yujun; Xiong, Wei; Liu, Weiqing; Fang, Hai; Lu, Weidong

    2015-01-01

    The plate of a pultruded fiber-reinforced polymer or fiber-reinforced plastic (FRP) profile produced via a pultrusion process is likely to undergo local buckling and cracking along the fiber direction under an external load. In this study, we constructed a pultruded glass-fiber-reinforced polymer-light wood composite (PGWC) profile to explore its mechanical performance. A rectangular cross-sectional PGWC profile was fabricated with a paulownia wood core, alkali-free glass fiber filaments, and unsaturated phthalate resin. Three-point bending and short column axial compression tests were conducted. Then, the stress calculation for the PGWC profile in the bending and axial compression tests was performed using the Timoshenko beam theory and the composite component analysis method to derive the flexural and axial compression rigidity of the profile during the elastic stress stage. The flexural capacity for this type of PGWC profile is 3.3-fold the sum of the flexural capacities of the wood core and the glass-fiber-reinforced polymer (GFRP) shell. The equivalent flexural rigidity is 1.5-fold the summed flexural rigidity of the wood core and GFRP shell. The maximum axial compressive bearing capacity for this type of PGWC profile can reach 1.79-fold the sum of those of the wood core and GFRP shell, and its elastic flexural rigidity is 1.2-fold the sum of their rigidities. These results indicate that in PGWC profiles, GFRP and wood materials have a positive combined effect. This study produced a pultruded composite material product with excellent mechanical performance for application in structures that require a large bearing capacity.

  3. Experimental Study of the Flexural and Compression Performance of an Innovative Pultruded Glass-Fiber-Reinforced Polymer-Wood Composite Profile.

    Directory of Open Access Journals (Sweden)

    Yujun Qi

    Full Text Available The plate of a pultruded fiber-reinforced polymer or fiber-reinforced plastic (FRP profile produced via a pultrusion process is likely to undergo local buckling and cracking along the fiber direction under an external load. In this study, we constructed a pultruded glass-fiber-reinforced polymer-light wood composite (PGWC profile to explore its mechanical performance. A rectangular cross-sectional PGWC profile was fabricated with a paulownia wood core, alkali-free glass fiber filaments, and unsaturated phthalate resin. Three-point bending and short column axial compression tests were conducted. Then, the stress calculation for the PGWC profile in the bending and axial compression tests was performed using the Timoshenko beam theory and the composite component analysis method to derive the flexural and axial compression rigidity of the profile during the elastic stress stage. The flexural capacity for this type of PGWC profile is 3.3-fold the sum of the flexural capacities of the wood core and the glass-fiber-reinforced polymer (GFRP shell. The equivalent flexural rigidity is 1.5-fold the summed flexural rigidity of the wood core and GFRP shell. The maximum axial compressive bearing capacity for this type of PGWC profile can reach 1.79-fold the sum of those of the wood core and GFRP shell, and its elastic flexural rigidity is 1.2-fold the sum of their rigidities. These results indicate that in PGWC profiles, GFRP and wood materials have a positive combined effect. This study produced a pultruded composite material product with excellent mechanical performance for application in structures that require a large bearing capacity.

  4. Experimental Study of the Flexural and Compression Performance of an Innovative Pultruded Glass-Fiber-Reinforced Polymer-Wood Composite Profile

    Science.gov (United States)

    Qi, Yujun; Xiong, Wei; Liu, Weiqing; Fang, Hai; Lu, Weidong

    2015-01-01

    The plate of a pultruded fiber-reinforced polymer or fiber-reinforced plastic (FRP) profile produced via a pultrusion process is likely to undergo local buckling and cracking along the fiber direction under an external load. In this study, we constructed a pultruded glass-fiber-reinforced polymer-light wood composite (PGWC) profile to explore its mechanical performance. A rectangular cross-sectional PGWC profile was fabricated with a paulownia wood core, alkali-free glass fiber filaments, and unsaturated phthalate resin. Three-point bending and short column axial compression tests were conducted. Then, the stress calculation for the PGWC profile in the bending and axial compression tests was performed using the Timoshenko beam theory and the composite component analysis method to derive the flexural and axial compression rigidity of the profile during the elastic stress stage. The flexural capacity for this type of PGWC profile is 3.3-fold the sum of the flexural capacities of the wood core and the glass-fiber-reinforced polymer (GFRP) shell. The equivalent flexural rigidity is 1.5-fold the summed flexural rigidity of the wood core and GFRP shell. The maximum axial compressive bearing capacity for this type of PGWC profile can reach 1.79-fold the sum of those of the wood core and GFRP shell, and its elastic flexural rigidity is 1.2-fold the sum of their rigidities. These results indicate that in PGWC profiles, GFRP and wood materials have a positive combined effect. This study produced a pultruded composite material product with excellent mechanical performance for application in structures that require a large bearing capacity. PMID:26485431

  5. Real-time measurements of temperature, pressure and moisture profiles in High-Performance Concrete exposed to high temperatures during neutron radiography imaging

    Energy Technology Data Exchange (ETDEWEB)

    Toropovs, N., E-mail: nikolajs.toropovs@rtu.lv [Empa, Swiss Federal Laboratories for Materials Science and Technology, Dübendorf (Switzerland); Riga Technical University, Institute of Materials and Structures, Riga (Latvia); Lo Monte, F. [Politecnico di Milano, Department of Civil and Environmental Engineering, Milan (Italy); Wyrzykowski, M. [Empa, Swiss Federal Laboratories for Materials Science and Technology, Dübendorf (Switzerland); Lodz University of Technology, Department of Building Physics and Building Materials, Lodz (Poland); Weber, B. [Empa, Swiss Federal Laboratories for Materials Science and Technology, Dübendorf (Switzerland); Sahmenko, G. [Riga Technical University, Institute of Materials and Structures, Riga (Latvia); Vontobel, P. [Paul Scherrer Institute, Laboratory for Neutron Scattering and Imaging, Villigen (Switzerland); Felicetti, R. [Politecnico di Milano, Department of Civil and Environmental Engineering, Milan (Italy); Lura, P. [Empa, Swiss Federal Laboratories for Materials Science and Technology, Dübendorf (Switzerland); ETH Zürich, Institute for Building Materials (IfB), Zürich (Switzerland)

    2015-02-15

    High-Performance Concrete (HPC) is particularly prone to explosive spalling when exposed to high temperature. Although the exact causes that lead to spalling are still being debated, moisture transport during heating plays an important role in all proposed mechanisms. In this study, slabs made of high-performance, low water-to-binder ratio mortars with addition of superabsorbent polymers (SAP) and polypropylene fibers (PP) were heated from one side on a temperature-controlled plate up to 550 °C. A combination of measurements was performed simultaneously on the same sample: moisture profiles via neutron radiography, temperature profiles with embedded thermocouples and pore pressure evolution with embedded pressure sensors. Spalling occurred in the sample with SAP, where sharp profiles of moisture and temperature were observed. No spalling occurred when PP-fibers were introduced in addition to SAP. The experimental procedure described here is essential for developing and verifying numerical models and studying measures against fire spalling risk in HPC.

  6. Effect of fatty acid profile in vegetable oils and antioxidant supplementation on dairy cattle performance and milk fat depression.

    Science.gov (United States)

    He, M; Armentano, L E

    2011-05-01

    This study was conducted to evaluate the effect of dietary supplementation of unprotected vegetable oils differing in fatty acid profiles with or without a commercial antioxidant (Agrado Plus, Novus International, St. Charles, MO) on dairy cattle performance, milk fatty acid profiles, and milk fat depression. Twenty-four multiparous Holstein cows were blocked by production (high and low) and assigned to Agrado Plus or no Agrado Plus diets as the main plot in this experiment. The 6 cows in each of the fixed effect groups (high with and without Agrado, low with and without Agrado) were then assigned to a 6 × 6 Latin square as a split plot with 21-d periods. The 6 dietary treatments in the split-plot Latin square were no added oil (control), or 5% DM as oil from palm (PO), high-oleic safflower (OSAF), high-linoleic safflower (LSAF), linseed (LNSD), or corn (CO). Added oil replaced corn starch in the total mixed ration. Diets were formulated to have similar crude protein and neutral detergent fiber, and consisted of 41.2% alfalfa silage, 18.3% corn silage, and 40.5% concentrate mix (dry matter basis). Feeding Agrado Plus did not affect milk, milk fat, or milk protein production or milk fatty acid composition in this study. No significant differences were found between oil feeding versus control for dry matter intake, milk yield, and milk protein yield, but oils other than PO significantly decreased milk fat concentration and proportion and yield of milk short- and medium-chain fatty acids (C(<16)). Feeding PO effectively maintained milk fat yield (1.18 kg/d) and concentration (3.44%), whereas the oils rich in linoleic acid (CO and LSAF) significantly decreased milk fat yield (0.98 and 0.86 vs. 1.14 kg/d) and concentration (3.05 and 2.83 vs. 3.41%) compared with control. Similar lactation performance between OSAF and LNSD suggests that oleic and linolenic acids are roughly equal in potency of milk fat depression. Copyright © 2011 American Dairy Science Association

  7. Supplementation of Dried Mealworm (Tenebrio molitor larva) on Growth Performance, Nutrient Digestibility and Blood Profiles in Weaning Pigs.

    Science.gov (United States)

    Jin, X H; Heo, P S; Hong, J S; Kim, N J; Kim, Y Y

    2016-07-01

    This experiment was conducted to investigate the effects of dried mealworm (Tenebrio molitor larva) on growth performance, nutrient digestibility and blood profiles in weaning pigs. A total of 120 weaning pigs (28±3 days and 8.04±0.08 kg of body weight) were allotted to one of five treatments, based on sex and body weight, in 6 replicates with 4 pigs per pen by a randomized complete block design. Supplementation level of dried mealworm was 0%, 1.5%, 3.0%, 4.5%, or 6.0% in experimental diet as treatment. Two phase feeding programs (phase I from 0 day to 14 day, phase II from 14 day to 35 day) were used in this experiment. All animals were allowed to access diet and water ad libitum. During phase I, increasing level of dried mealworm in diet linearly improved the body weight (p<0.01), average daily gain (ADG) (p<0.01) and average daily feed intake (ADFI) (p<0.01). During phase II, ADG also tended to increase linearly when pigs were fed higher level of dried mealworm (p = 0.08). In addition, increasing level of dried mealworm improved the ADG (p<0.01), ADFI (p<0.05) and tended to increase gain to feed ratio (p = 0.07) during the whole experimental period. As dried mealworm level was increased, nitrogen retention and digestibility of dry matter as well as crude protein were linearly increased (p = 0.05). In the results of blood profiles, decrease of blood urea nitrogen (linear, p = 0.05) and increase of insulin-like growth factor (linear, p = 0.03) were observed as dried mealworm was increased in diet during phase II. However, there were no significant differences in immunoglobulin A (IgA) and IgG concentration by addition of dried mealworm in the growth trial. Consequently, supplementation of dried mealworm up to 6% in weaning pigs' diet improves growth performance and nutrient digestibility without any detrimental effect on immune responses.

  8. The effect of grazing intensity and supplementation on performance, stress indicators and metabolic profiles of finishing lambs

    Directory of Open Access Journals (Sweden)

    João Paulo Ramos Costa

    2015-12-01

    Full Text Available In the present study, the effect of grazing intensity (GI and feed supplementation in sixty-four crossbred Santa Inês lambs was assessed based on performance, blood stress indicators, and metabolic profiles. The GIs analyzed were VH = very high, H = high, L = low, and VL = very low, and were represented by the residual leaf area index (LAIr. The lambs were divided into two groups, supplemented (SP and non-supplemented (NSP. The dry matter intake (DMI and average daily gain (ADG increased linearly with decreasing GI (P < 0.05, and the ADG was higher for the NSP group than the SP group (P < 0.05. The plasma cortisol concentration was higher in the NSP group (P < 0.05, and it was not affected by GIs (P > 0.05. The neutrophil:lymphocyte (N:L ratio decreased linearly with GI (P < 0.05, and the SP group had a higher N:L ratio (P < 0.05. None of the parameters evaluated for protein metabolism were affected by GI (P > 0.05, except albumin, where the SP group had a higher concentration of this metabolite (P < 0.05. Regarding energy metabolism indicators, glucose showed a linear increase with a decrease in GI (P < 0.05 and was higher in the SP group (P < 0.05; however, there was a decreasing linear effect (P < 0.05 and the NSP group had higher serum levels (P < 0.05 of non-esterified fatty acids (NEFA. The concentration of beta hydroxybutyrate (HBA-B was higher in the SP group (P < 0.05. The concentration of calcium was affected by GI (P < 0.05. The phosphorus concentration was higher in the SP group (P < 0.05, and concentration of magnesium was not affected by any of the treatments (P > 0.05. It was concluded that GI and SP modified the performance, stress indicators, and metabolic profiles of finishing lambs.

  9. A comparative performance study of a photovoltaic concentrator system with discrete mirror and continuos profile for two different absorber shapes

    Energy Technology Data Exchange (ETDEWEB)

    H, Saiful; Rezau, K.M [University of Dhaka, Dhaka (Bangladesh)

    2000-07-01

    Profiles of parabolic concentrators of discrete mirror and continuos surface mirror have been designed for combined electrical thermal photovoltaic systems. In the design the changes of concentration ratio, effect of reflection, angle of incidence over the absorber have been taken into account for maximum energy collection. The performances of the system are studied for solar cells of modified grid finger for illuminations from 1-10 sun. The local concentration ratio (LCR) distribution over the absorbers for both the concentrator, the optical efficiency, thermal efficiency, electrical and thermal power output and overall efficiency have been evaluated for different values of beam radiation concentration ratio and focal distance. [Spanish] Se han disenado perfiles de concentradores parabolicos de espejo discreto y de superficie continua para sistemas fotovoltaicos combinados electricos y termicos. En el diseno los cambios de la proporcion de concentracion, del efecto de la reflexion, del angulo de incidencia sobre el observador se han tenido en cuenta para una maxima recoleccion de energia. Los rendimientos del sistema se han estudiado para celdas solares de parrilla modificada para iluminaciones solares de 1-10. Han sido evaluados para diferentes valores de la proporcion de la concentracion de la radiacion en el rayo y la distancia focal la proporcion de concentracion local (LCR) de la distribucion en los absorbedores, para el concentrador la eficiencia optica, la eficiencia termica, electrica, la produccion de energia termica y electrica y la eficiencia total.

  10. Influences of Phytoncide Supplementation on Growth Performance, Nutrient Digestibility, Blood Profiles, Diarrhea Scores and Fecal Microflora Shedding in Weaning Pigs

    Directory of Open Access Journals (Sweden)

    S. Zhang

    2012-09-01

    Full Text Available A total of 140 weaning pigs ((Landrace×Yorkshire×Duroc, BW = 6.47±0.86 kg were used in a 5-wk growth trail to determine the effects of phytoncide supplementation on growth performance, nutrient apparent total tract digestibility (ATTD, blood profiles, diarrhea scores and fecal microflora shedding. Pigs were assigned randomly by BW into 5 treatments, dietary treatments were: i NC, basal diet; ii PC, NC+0.05% tylosin; iii EO, NC+0.1% essential oil; iv PP, NC+0.2% PP (phytoncide with 2% citric acid, and v PA, NC+0.2% PA (phytoncide. Each treatment had 7 replicate pens with 4 pigs per pen. All pigs were housed in pens with a self-feeder and nipple drinker to allow ad libitum access to feed and water throughout the experimental period. During 0 to 2 wks, supplementation with essential oil and PA decreased (p0.05 was observed in diarrhea scores among treatments. In conclusion, phytoncide can elevate feed efficiency, nutrient digestibility, and improve the fecal Lactobacillus counts in weaning pigs. Our results indicated that the phytoncide could be used as a good antibiotics alternative in weaning pigs.

  11. Amino acid profile of saliva from patients with oral squamous cell carcinoma using high performance liquid chromatography.

    Science.gov (United States)

    Reddy, Indira; Sherlin, Herald J; Ramani, Pratibha; Premkumar, Priya; Natesan, Anuja; Chandrasekar, Thiruvengadam

    2012-09-01

    Oral cancer is the leading cause of death worldwide and it is the eighth most common cause of cancer death. Cancer cells utilize more glucose and amino acids than their benign counterparts. Diagnosis of disease via the analysis of saliva is potentially valuable, as the collection of fluid is associated with fewer compliance problems than the collection of blood. Hence, the present study was undertaken to evaluate the comprehensive amino acid profiling of saliva by high performance liquid chromatography (HPLC). The study group comprised 16 subjects, of whom eight were classified as having well-differentiated oral squamous (OSCC) cell carcinoma (Group I) and eight were classified as having moderately differentiated oral squamous cell carcinoma (Group II). Eight healthy individuals comprised the control group (Group III). The results showed increased salivary levels of all the amino acids in both groups of OSCC patients (Groups I and II) when compared with healthy controls (Group III). Hence, our study showed higher levels of all amino acids in the saliva of OSCC patients than in the saliva of healthy controls. The increased levels may serve as a "diagnostic and prognostic marker" for oral squamous cell carcinoma and for further detection of metastatic spread.

  12. Performance of South African children on the Communication and Symbolic Behavior Scales-Developmental Profile (CSBS DP).

    Science.gov (United States)

    Chambers, Nola; Stronach, Sheri T; Wetherby, Amy M

    2016-05-01

    Substantial development in social communication skills occurs in the first two years of life. Growth should be evident in sharing emotion and eye gaze; rate of communication, communicating for a variety of functions; using gestures, sounds and words; understanding language, and using functional and pretend actions with objects in play. A delay in these early social communication skills may be the first sign of a developmental delay in young children in nearly all categories of disabilities-including specific language impairment, autism spectrum disorder, HIV/AIDS, lack of environmental stimulation or institutionalization, and global developmental delays-and early detection of these delays is critical for enrolment in appropriate early intervention services. No standardized tests of early social communication skills exist for very young children in South Africa (SA). An existing evaluation tool that has the potential to be culturally fair for children from cultural backgrounds different to the standardization group is the Communication and Symbolic Behaviour Scales-Developmental Profile (CSBS DP). This study aimed to document the performance of a group of English-speaking SA children ranging in age from 12 to 24 months on the CSBS DP and to compare this performance with the original standardization sample. Sixty-seven English-speaking SA children from a range of cultural and linguistic backgrounds were assessed on the CSBS DP Behaviour Sample. Group scores were compared with the original standardization sample using inferential statistics. The results provide preliminary support for the suitability and validity of the face-to-face Behaviour Sample as a measure of early social communication skills in this sample of English-speaking SA children from a range of cultural groups between 12 and 24 months of age. While further research in the SA population is needed, these findings are a first step towards validating a culturally appropriate measure for early detection of

  13. Effects of wheat supplementation levels on growth performance, blood profiles, nutrient digestibility, and pork quality in growing-finishing pigs

    Directory of Open Access Journals (Sweden)

    Tae Hee Han

    2017-08-01

    Full Text Available Objective This study was conducted to evaluate various wheat supplementation levels on growth performance, blood profiles, nutrient digestibility, and pork quality in growing-finishing pigs. Methods A total of 120 growing pigs ([Yorkshire×Landrace]×Duroc, with an average 27.75± 1.319 kg body weight, were used in growth trial. Pigs were allotted into each treatment by body weight and sex in 4 replicates with 6 pigs per pen in a randomized complete block design. Four-phase feeding programs were used in this experiment. The treatments included the following: i corn-soybean meal (SBM – based diet (CON, ii corn-SBM – based diet+15% of wheat (W15, iii corn-SBM – based diet+30% of wheat (W30, iv corn-SBM – based diet+45% of wheat (W45, and 5 corn-SBM–based diet+60% of wheat (W60. Results There was no significant difference in growth performance among the dietary treatments. However, the gain-to-feed (G:F ratio tended to increase (quadratic, p<0.08 when the pigs were fed a higher wheat diet during the finishing period. The digestibility of crude ash and fat tended to decrease as the wheat supplementation level increased (p<0.08. The proximate analysis of the longissimus muscle was not affected by the dietary level of wheat. The crude ash content in pork was decreased linearly as the wheat supplementation level increased (p = 0.05. There was no significant difference in the pH level, shear force, water holding capacity, and cooking loss of the pork. In pork and fat, L*, a*, and b* values were not significantly different among dietary treatments. Conclusion Wheat can be supplemented up to 60% in a growing-finishing pig without detrimental effects on growth and pork quality. The G:F ratio tended to improve in the finishing period by wheat inclusion.

  14. Influence of the domestic hot-water daily draw-off profile on the performance of a hot-water store

    Energy Technology Data Exchange (ETDEWEB)

    Spur, Roman [Czech Technical University in Prague (Czech Republic). Department of Environmental and Building Services, Faculty of Civil Engineering; Fiala, Dusan [Institute of Energy and Sustainable Development, De Montfort University, Leicester (United Kingdom); Nevrala, Dusan [Enplan - Heating Technology Company, Prague (Czech Republic); Probert, Doug [Cranfield University, Bedford (United Kingdom). School of Engineering

    2006-07-15

    An enhanced TRNSYS simulation model, NEM, of the behaviour of a domestic hot-water (DHW) store, with an immersed heat-exchanger (HX), has been developed and validated. This model simulates the dynamic heat-depletion and recovery processes in the immersed HX and predicts the transient temperature-patterns for various DHW draw-off versus time profiles. Realistic daily profiles (RDPs), based on field studies, were developed to provide representative draw-off patterns for the testing of thermal stores and simulation studies. The effects of these RDPs and five other existing profiles on the store's performance are analysed using the enhanced model. The simulation results indicate the importance of the HX's recovery, as well as the number, type and time of occurrence of the draw-offs in the profile, on the thermal store's performance. It is concluded that RDP profiles should be used in the performance testing of thermal stores to obtain results that reflect conditions experienced in the field. (author)

  15. Jersey calf performance in response to high-protein, high-fat liquid feeds with varied fatty acid profiles: intake and performance.

    Science.gov (United States)

    Bowen Yoho, W S; Swank, V A; Eastridge, M L; O'Diam, K M; Daniels, K M

    2013-04-01

    The objective of this study was to determine whether altering the fatty acid (FA) profile of milk replacer (MR) with coconut oil, which contains a high concentration of medium-chain FA, to more closely match the FA profile typically found in whole milk from Jersey cows, would improve Jersey calf performance. Male (n=18) and female (n=32) Jersey calves were assigned at birth to 1 of 4 liquid diets: (1) pasteurized Jersey saleable whole milk [pSWM; 27.9% crude protein (CP) and 33.5% fat]; (2) 29.3% CP and 29.1% fat MR, containing 100% of fat as edible lard (100:00); (3) 28.2% CP and 28.0% fat MR, containing 80% of fat as lard and 20% as coconut oil (80:20); and (4) 28.2% CP and 28.3% fat MR, containing 60% of the fat as lard and 40% as coconut oil (60:40). Calves were fed their respective liquid diet twice daily during wk 1 through 7 and once daily until weaning (approximately wk 8). Calves had ad libitum access to grain and water, and calves were monitored 1 wk postweaning. Average daily gain and body weight did not differ by treatment. Calves fed pSWM tended to have greater hip height (HH) than calves fed 80:20 (80.5 vs. 79.7 cm). Coconut oil tended to have a quadratic effect on HH, with calves fed 100:00, 80:20, and 60:40 at 79.2, 79.7, and 78.5 cm, respectively. No difference was observed in withers height between pSWM and 80:20. Coconut oil had a quadratic effect on withers height, with calves fed 100:00, 80:20, and 60:40 at 76.6, 77.5, and 76.5 cm, respectively. Change in HH from birth to 9 wk tended to be greater for calves fed pSWM than calves fed 80:20 (0.218 vs. 0.194 cm/d). Calves fed pSWM had higher milk dry matter intake (DMI) than calves fed 80:20 (0.580 vs. 0.518 kg/d). No effect of coconut oil was observed on milk DMI. Grain DMI and total DMI did not differ among treatments. Calves fed pSWM had an increase in days with a fecal score >2 compared with calves fed 80:20 (4.24 vs. 2.00 d). Coconut oil had a quadratic effect on fecal score, with calves fed

  16. Return to play and performance after anterior cruciate ligament reconstruction in the National Basketball Association: surgeon case series and literature review.

    Science.gov (United States)

    Nwachukwu, Benedict U; Anthony, Shawn G; Lin, Kenneth M; Wang, Tim; Altchek, David W; Allen, Answorth A

    2017-09-01

    To investigate return to play (RTP) and functional performance after anterior cruciate ligament reconstruction (ACLR) in National Basketball Association (NBA) players and to perform a systematic review of the literature to understand RTP after ACLR in professional basketball. NBA players undergoing ACLR between 2008 and 2014 by two surgeons were identified. RTP and performance were assessed based on a review of publically available statistics. A systematic review of the literature was performed using the MEDLINE database. Inclusion criteria were: English language, ACL surgery outcome, professional basketball and RTP outcome. We reviewed studies for RTP rates and RTP performance. Our study included 12 professional basketball players with NBA level experience. Eleven of the 12 players returned to their prior level of play. Eight of the 9 (88.9%) players actively playing in the NBA returned to play in the NBA at a mean 9.8 months. Among players returning to NBA play, during RTP season 1, mean per game statistics decreased for the following: minutes, points, rebounds, assists, steals, blocks, turnovers and personal fouls - none of these changes reached statistical significance. Player efficiency ratings significantly declined from pre-injury (12.5) to the first RTP season (7.6) (p = 0.05). By RTP season 2, player performance metrics approximated pre-injury levels and were not significantly different. Six studies met inclusion criteria; reported RTP rates ranged from 78-86%. Identified studies similarly found a decline in functional performance after RTP. There is a high rate (89%) of return to NBA play for NBA players undergoing ACLR. After RTP, however, there is a quantitative decline in initial season 1 RTP statistics with a significant decrease in player efficiency rating. By RTP season 2, performance metrics demonstrated an improvement compared to RTP season 1 but did not reach pre-injury functional performance, though performance metrics are not significantly

  17. Influence of post hatch dietary supplementation of fat on performance, carcass cuts and biochemical profile in Ven Cobb broiler

    Directory of Open Access Journals (Sweden)

    Komal Prasad Rai

    2015-02-01

    Full Text Available Aim: The present experiment was conducted to study the effect of post hatch dietary fat supplementation on performance of broiler chicken. Materials and Methods: A total of 120 day-old Ven Cobb broiler chicks were randomly assigned to 4 treatment groups of 30 chicks in each (three replicates of 10 birds/treatment. The trial lasted for 35 days. The experimental design was a completely randomized design. Four types of diet were formulated for 1st week: T1, T2, T3 and T4 contained control diet with no added fat, 2.5, 5 and 7.5% fat, respectively. After 1st week post-hatch period chicks were fed ad libitum with the normal basal diet as per Bureau of Indian Standard recommendations till completion of the experiment (8-35 days. Results: Significantly higher (p<0.05 body weight and improved feed conversion ratio (FCR was recorded in birds fed 5% dietary fat at the end of the experiment whereas, feed intake was not significantly affected. Significantly (p<0.05 higher dressed weight was observed due to 5% fat supplementation than other groups whereas, it was not significant for other carcass cuts. No significant differences were observed in moisture, protein and lipid content of breast and thigh muscle of broiler due to supplemented fat whereas, 2.5% dietary fat significantly (p<0.05 increase the serum HI titer on day 28th. In biochemical profile, higher serum albumin (g/dl was recorded due to 5% fat supplementation whereas other biochemical components did not show any significance difference among treatments. Conclusion: It may be concluded that supplementation of fat in broilers diet improves the overall FCR, dressing percentage and gain more body weight.

  18. SUPPLEMENTATION OF COFFEE HUSK FERMENTED WITH Pleurotus ostreatus: EFFECT ON PERFORMANCE AND BLOOD PROFILE OF GASTROINTESTINAL NEMATODES INFECTED GOAT

    Directory of Open Access Journals (Sweden)

    I. Badarina

    2016-03-01

    Full Text Available The aim of this study was to investigate the potency of coffee husk fermented with P.ostreatus as a natural anthelmintic supplement by measuring the performance and blood profile of goat suffered gastrointestinal nematodes infection. Eighteen local male goats of Kacang goat with body weight of 9.23 ± 1.71 kg and aged at ± 10 months were arranged into three treatments in completely randomized design. The treatments were T0 (group without chemical anthelmintic treatment and no supplementation of fermented coffee husk, T1 (without chemical anthelmintic treatment, but supplied with fermented coffee husk and T2 (group with chemical anthelmintic and no supplementation of fermented coffee husk. All goats were offered a basal diet in the ratio of 60% natural grasses along with 40% concentrate. Fermented coffee husk was added in the diet as much as 6% from the dry matter need. The result showed that there were no significant effect to dry matter intake, daily weight gain, PCV value and eosinophil counts (P>0.05. The supplementation of fermented coffee husk (T1 enhanced Hb and red blood cell (RBC value (P<0.05 while no significant difference to T2. There were no nematodes infection in T1 and T2 with the eggs count were zero while the animals in T0 were still infected. This result indicated that fermented coffee husk can be used as a promising natural anthelmintic supplement with the improvement of Hb value, RBC, egg counts and daily weight gain.

  19. Monitoring performance, pituitary-adrenal hormones and mood profiles: how to diagnose non-functional over-reaching in male elite junior soccer players.

    Science.gov (United States)

    Schmikli, Sándor L; de Vries, Wouter R; Brink, Michel S; Backx, Frank Jg

    2012-11-01

    To verify if in male elite junior soccer players a minimum 1-month performance decrease is accompanied by a mood profile and hormone levels typical of non-functional over-reaching (NFOR). A prospective case-control study using a monthly performance monitor with a standardised field test to detect the performance changes. Players with a performance decrease lasting at least 1 month were compared with control players without a performance decrease on mood scores and pre-exercise and postexercise levels of stress hormones. Sporting field and sports medical laboratory. Ninety-four young elite soccer players were monitored during the 2006-2008 seasons. Twenty-one players were invited to the laboratory, seven of whom showed a significant performance decrease. Performance change over time, scores on the profile of mood states and premaximal and postmaximal exercise serum levels of adrenocorticotropic hormone (ACTH), growth hormone (GH) and cortisol. Players with a performance decrease showed psychological and hormonal changes typical of the non-functional state of over-reaching. Scores were higher on depression and anger, whereas the resting GH levels and ACTH levels after maximal exercise were reduced. ACTH and GH were capable of classifying all but one player correctly as either NFOR or control. Performance-related criteria in field tests are capable of identifying players with worsened mood and adaptations of the endocrine system that fit the definition of NFOR. Performance, mood and hormone levels may therefore be considered as valid instruments to diagnose NFOR in young elite soccer players.

  20. Effects of essential oils on performance, egg quality, nutrient digestibility and yolk fatty acid profile in laying hens

    Directory of Open Access Journals (Sweden)

    Xuemei Ding

    2017-06-01

    Full Text Available The study was conducted to investigate the effect of essential oils on performance, egg quality, nutrient digestibility and yolk fatty acid profile in laying hens. A total of 960 Lohmann laying hens aged 53 weeks were enrolled, under 4 different treatment diets supplemented with 0, 50, 100 and 150 mg/kg essential oils (Enviva EO, Dupont Nutrition Biosciences ApS, Denmark, respectively. Each treatment was replicated 8 times with 30 birds each. Birds were fed dietary treatment diets for 12 weeks (54 to 65 weeks. For data recording and analysis, a 12-week period was divided into 3 periods of 4 weeks' duration each: period 1 (54 to 57 weeks, period 2 (58 to 61 weeks, and period 3 (62 to 65 weeks. For the diet supplemented with Enviva EO, hen-day egg production and the feed conversion ratio (FCR were significantly improved (P < 0.05 at weeks 58 to 61, and the eggshell thickness was significantly increased (P < 0.05 at week 65. However, egg production, egg weight, feed intake, FCR and other egg quality parameters (albumen height, Haugh unit, egg yolk color and eggshell strength were not affected by the dietary treatment. In addition, compared with the control diet, protein digestibility in the 100 mg/kg Enviva EO treatment group was significantly increased (P < 0.05, and fat digestibility in the 100 and 150 mg/kg Enviva EO treatment groups was significantly decreased (P < 0.05, but Enviva EO had no effect on energy apparent digestibility. Saturated fatty acid (SFA and monounsaturated fatty acid (MUFA gradually decreased and polyunsaturated fatty acid (PUFA increased with Enviva EO supplementation, but the difference was not significant. The data suggested that the supplementation of essential oils (Enviva EO in laying hen diet did not show a significant positive effect on performance and yolk fatty acid composition but it tended to increase eggshell thickness and protein digestibility, especially at the dose of 50 mg/kg.

  1. High performance liquid chromatographic profiles of nucleosides, bases and tryptophan in the plasma of the Tasmanian devil and four other marsupial species.

    Science.gov (United States)

    Sallis, J D; Nicol, S C; Perrone, P; Brown, P R

    1984-01-01

    Plasma profiles of nucleosides, bases and trytophan of five marsupial species were established using the reversed-phase mode of high performance liquid chromatography (RHPLC). Within each species, the profiles were highly reproducible and between species there were distinct differences. In the Tasmanian devil, the circulating levels of constituents examined with one exception, were generally lower than in the other marsupials. The exception was a constituent present in large amounts and having the characteristics of a purine nucleoside derivative which was found only in the plasma of the devil.

  2. Ultra high performance liquid chromatography tandem mass spectrometry determination and profiling of prohibited steroids in human biological matrices. A review.

    Science.gov (United States)

    Gosetti, Fabio; Mazzucco, Eleonora; Gennaro, Maria Carla; Marengo, Emilio

    2013-05-15

    list of the prohibited substances of the World Anti-Doping Agency (WADA). In WADA list steroids figure in three main classes, namely anabolic steroids, corticosteroids and substances with anti-estrogenic properties. It must be strongly reminded that assumption of doping agents not only leads to athletes the possible failing of doping tests but causes important health risk and WADA prohibited list establishes criteria to highlight the alteration of the natural steroid profile caused by exogenous administration. Doping control analyses are generally performed in urine, a matrix that provides a prolonged detection time window, and less often in blood, serum, plasma, hair, saliva, and nails. To identify the chemical structures of anabolic steroids the use of mass spectrometry detection is very advantageous. Gas chromatography-mass spectrometry (GC-MS) techniques allowed for the development of comprehensive screening methods. GC-MS methods are sensitive and robust but present the disadvantages of time-consuming sample pretreatment, that is often based on hydrolysis and derivatisation reactions. Liquid chromatography-mass spectrometry (LC-MS) methods have been successfully used to identify and determinate steroids in different matrices, as well as to study their metabolisms. Nowadays, automatic rapid ultra high performance liquid chromatography (UHPLC) tandem mass spectrometry has become the technique of choice for steroid analysis. Due to its generally higher speed, sensitivity, reproducibility and specificity with respect to HPLC, it can be used to simultaneously separate and determinate multi component steroid mixtures. The technique is of huge interest to separate conjugates anabolic androgenic steroids, as it allows efficiency enhancement due to the small particle (sub-2μm) column packing, which provides high peak capacity within analysis times even 5-10 fold shorter than conventional HPLC methods. Modern multiplex instruments can analyze thousands of samples per month

  3. Comparison of ultra-high performance methods in liquid and supercritical fluid chromatography coupled to electrospray ionization - mass spectrometry for impurity profiling of drug candidates.

    Science.gov (United States)

    Lemasson, Elise; Bertin, Sophie; Hennig, Philippe; Lesellier, Eric; West, Caroline

    2016-11-11

    Impurity profiling of organic products synthesized as possible drug candidates represents a major analytical challenge. Complementary analytical methods are required to ensure that all impurities are detected. Both high-performance liquid chromatography (HPLC) and supercritical fluid chromatography (SFC) can be used for this purpose. In this study, we compared ultra-high performance HPLC (UHPLC) and ultra-high performance SFC (UHPSFC) using a large dataset of 140 pharmaceutical compounds. Four previously optimized methods (two on each technique) were selected to ensure fast high-resolution separations. The four methods were evaluated based on response rate, peak capacity, peak shape and capability to detect impurities (UV). The orthogonality between all methods was also assessed. The best UHPLC method and UHPSFC methods provided comparable quality for the 140 compounds included in this study. Moreover, they were found to be highly orthogonal. At last, the potential of the combined use of UHPLC and UHPSFC for impurity profiling is illustrated with practical examples.

  4. Comparison effects of dietary iron dextran and bacterial-iron supplementation on growth performance, fecal microbial flora, and blood profiles in sows and their litters.

    Science.gov (United States)

    Zhao, Pinyao; Upadhaya, Santi Devi; Li, Jian; Kim, Inho

    2015-11-01

    This study was conducted to compare effects of dietary administration of iron dextran and bacterial-iron on growth performance, fecal microbial flora, and blood profiles in sows and their litters. A total of 20 multiparous sows (Landrace × Yorkshire) were randomly allotted into two treatments: (i) ID (basal diet, piglets were injected with iron dextran); (ii) BR (basal diet + bacterial-iron; bacterial-iron was given to sows, piglets were not injected with iron dextran). There were five replicates per treatment with two sows per replicate. No differences were observed on sow and piglet growth performance, fecal microbial flora as well as sow blood profiles between ID and BR treatments. In piglets, blood iron, red blood cell and hemoglobin concentrations in ID treatment were higher (P growth performance in lactating sows and piglets, but iron dextran injection has higher blood iron, white blood cell, red blood cell and hemoglobin concentrations in piglets.

  5. Integrating fluorescent dye flow-curve testing and acoustic Doppler velocimetry profiling for in situ hydraulic evaluation and improvement of clarifier performance.

    Science.gov (United States)

    Tarud, F; Aybar, M; Pizarro, G; Cienfuegos, R; Pastén, P

    2010-08-01

    Enhancing the performance of clarifiers requires a thorough understanding of their hydraulics. Fluorescence spectroscopy and acoustic doppler velocimeter (ADV) profiling generally have been used separately to evaluate secondary settlers. We propose that simultaneous use of these techniques is needed to obtain a more reliable and useful evaluation. Experiments were performed on laboratory- and full-scale clarifiers. Factors affecting Fluorescein and Rhodamine 6G properties were identified. Underestimations up to 500% in fluorescence intensities may be derived from differential fluorescence quenching by oxygen. A careful control and interpretation of fluorescent dye experiments is needed to minimize artifacts in real settings. While flow-curve tests constructed under controlled conditions provided a more accurate overall quantitative estimation of the hydraulic performance, ADV velocity and turbulence profiling provided a detailed spatial understanding of flow patterns that was used to troubleshoot and fix the causes of hydraulic short-circuits.

  6. Enhanced performance of CdS/CdTe thin-film devices through temperature profiling techniques applied to close-spaced sublimation deposition

    Energy Technology Data Exchange (ETDEWEB)

    Xiaonan Li; Sheldon, P.; Moutinho, H.; Matson, R. [National Renewable Energy Lab., Golden, CO (United States)

    1996-05-01

    The authors describe a methodology developed and applied to the close-spaced sublimation technique for thin-film CdTe deposition. The developed temperature profiles consisted of three discrete temperature segments, which the authors called the nucleation, plugging, and annealing temperatures. They have demonstrated that these temperature profiles can be used to grow large-grain material, plug pinholes, and improve CdS/CdTe photovoltaic device performance by about 15%. The improved material and device properties have been obtained while maintaining deposition temperatures compatible with commercially available substrates. This temperature profiling technique can be easily applied to a manufacturing environment by adjusting the temperature as a function of substrate position instead of time.

  7. Integrated inertial sensors and mobile computing for real-time cycling performance guidance via pedaling profile classification.

    Science.gov (United States)

    Xu, James Y; Nan, Xiaomeng; Ebken, Victor; Wang, Yan; Pottie, Greg J; Kaiser, William J

    2015-03-01

    Today, the bicycle is utilized as a daily commute tool, a physical rehabilitation asset, and sporting equipment, prompting studies into the biomechanics of cycling. Of the number of important parameters that affect cycling efficiency, the foot angle profile is one of the most important as it correlates directly with the effective force applied to the bike. However, there has been no compact and portable solution for measuring the foot angle and for providing the cyclist with real-time feedback due to a number of difficulties of the current tracking and sensing technologies and the myriad types of bikes available. This paper presents a novel sensing and mobile computing system for classifying the foot angle profiles during cycling and for providing real-time guidance to the user to achieve the correct profile. Continuous foot angle tracking is firstly converted into a discrete problem requiring only recognition of acceleration profiles of the foot using a single shoe mounted tri-axial accelerometer during each pedaling cycle. A classification method is then applied to identify the pedaling profile. Finally, a mobile solution is presented to provide real-time signal processing and guidance.

  8. Performance Assessment of Model-Based Optimal Feedforward and Feedback Current Profile Control in NSTX-U using the TRANSP Code

    Science.gov (United States)

    Ilhan, Z.; Wehner, W. P.; Schuster, E.; Boyer, M. D.; Gates, D. A.; Gerhardt, S.; Menard, J.

    2015-11-01

    Active control of the toroidal current density profile is crucial to achieve and maintain high-performance, MHD-stable plasma operation in NSTX-U. A first-principles-driven, control-oriented model describing the temporal evolution of the current profile has been proposed earlier by combining the magnetic diffusion equation with empirical correlations obtained at NSTX-U for the electron density, electron temperature, and non-inductive current drives. A feedforward + feedback control scheme for the requlation of the current profile is constructed by embedding the proposed nonlinear, physics-based model into the control design process. Firstly, nonlinear optimization techniques are used to design feedforward actuator trajectories that steer the plasma to a desired operating state with the objective of supporting the traditional trial-and-error experimental process of advanced scenario planning. Secondly, a feedback control algorithm to track a desired current profile evolution is developed with the goal of adding robustness to the overall control scheme. The effectiveness of the combined feedforward + feedback control algorithm for current profile regulation is tested in predictive simulations carried out in TRANSP. Supported by PPPL.

  9. Evaluation of high-performance liquid chromatography laser-induced fluorescence for serum protein profiling for early diagnosis of oral cancer

    Science.gov (United States)

    Patil, Ajeetkumar; Prabhu, Vijendra; Choudhari, K. S.; Unnikrishnan, V. K.; George, Sajan D.; Ongole, Ravikiran; Pai, Keerthilatha M.; Shetty, Jayarama K.; Bhat, Sujatha; Kartha, Vasudevan Bhaskaran; Chidangil, Santhosh

    2010-11-01

    The present work deals with the evaluation of a high-performance liquid chromatography laser-induced fluorescence (HPLC-LIF) technique developed in our laboratory for early detection of oral cancer from protein profiles of body fluids. The results show that protein profiles of serum samples from a given class of samples, say, normal, premalignant, or malignant, are statistically very close to each other, while profiles of members of any class are significantly different from other classes. The performance of the technique is evaluated by the use of sensitivity and specificity pairs, receiver operating characteristic (ROC) analysis, and Youden's Index. The technique uses protein profile differences in serum samples, registered by the HPLC-LIF technique. The study is carried out using serum samples from volunteers diagnosed as normal or premalignant clinically, and as malignant by histopathology. The specificities and sensitivities of the HPLC-LIF method at an ideal threshold (M-distance = 2) for normal, malignant, and premalignant classes are 100, 69.5, and 61.5%, and 86.5, 87.5, and 87.5% respectively.

  10. Neuropsychological profile of psychogenic jerky movement disorders : Importance of evaluating non-credible cognitive performance and psychopathology

    NARCIS (Netherlands)

    Heintz, Carolien E. J.; van Tricht, Mirjam J.; van der Salm, Sandra M. A.; van Rootselaar, A. F.; Cath, Danielle; Schmand, Ben; Tijssen, Marina A. J.

    2013-01-01

    Background Psychogenic movement disorders are disorders of movements that cannot be explained by a known neurological disorder and are assumed to be associated with psychiatric symptoms such as depression and anxiety. Objective To examine the neuropsychological profile of patients with psychogenic m

  11. Neuropsychological profile of psychogenic jerky movement disorders: Importance of evaluating non-credible cognitive performance and psychopathology

    NARCIS (Netherlands)

    Heintz, C.E.J.; van Tricht, M.J.; van der Salm, S.M.A.; van Rootselaar, A.F.; Cath, D.; Schmand, B.; Tijssen, M.A.J.

    2013-01-01

    Background: Psychogenic movement disorders are disorders of movements that cannot be explained by a known neurological disorder and are assumed to be associated with psychiatric symptoms such as depression and anxiety. Objective: To examine the neuropsychological profile of patients with psychogenic

  12. Motor development profile in 9-11 year-old children from the municipal education system of Maceio, Alagoas State, presenting low school performance

    Directory of Open Access Journals (Sweden)

    Maria Natália Santos da Silva

    2014-04-01

    Full Text Available Introduction: Children may present motor development delays that can influence their learning process, hence the need for specific assessment for the early detection of such delays in an attempt to resolve or mitigate possible future damage. Objective: Profile of motor development in children aged 9-11 years old presenting low academic achievement in the municipal education system of Maceio, Alagoas state. Methodology: An exploratory, descriptive, transversal study which uses the Motor Development Scale (MDS to analyze the main components of performance. Evaluations were carried out with 43 children of both genders. Results: The children assessed presented motor profiles ranging from “normal” to “far below average”, corroborating the findings in the literature. Conclusions: The results obtained are in agreement with the literature, showing a close relation between motor development and low school performance, emphasizing the importance of psychomotor intervention for the maturation of more complex motor patterns.

  13. Oxide thickness-dependent effects of source doping profile on the performance of single- and double-gate tunnel field-effect transistors

    Science.gov (United States)

    Chien, Nguyen Dang; Shih, Chun-Hsing

    2017-02-01

    Operated by the band-to-band tunneling at the source-channel junction, the source engineering has been considered as an efficient approach to enhance the performance of tunnel field-effect transistors (TFETs). In this paper, we report a new feature that the effects of source doping profile on the performance of single- and double-gate germanium TFETs depend on equivalent oxide thickness (EOT). Based on the numerical simulations, it is shown that the effect of source concentration on the on-current is stronger with decreasing the EOT, particularly in the double-gate configuration due to the higher gate control capability. Importantly, when the EOT is decreased below a certain value, abrupt source-channel junctions are not only unnecessary, but gradual source doping profiles even improve the performance of TFETs because of the increase in vertical tunneling generation. With the continuous trend of scaling EOT, the oxide thickness-dependent effects of source doping profile should be properly considered in designing TFET devices.

  14. Performance of flash profile and napping with and without training for describing small sensory differences in a model wine

    DEFF Research Database (Denmark)

    Liu, Jing; Grønbeck, Marlene Schou; Di Monaco, Rosella

    2016-01-01

    generation step and limiting the number of attributes for ranking gave a similar sample space. The Napping method could best highlight qualitative sample differences, whereas the Flash Profile provided a more precise product mapping on quantitative differences between model wines.......Publication date: March 2016 Source:Food Quality and Preference, Volume 48, Part A Author(s): Jing Liu, Marlene Schou Grønbeck, Rossella Di Monaco, Davide Giacalone, Wender L.P. Bredie Rapid sensory methods are a convenient alternative to conventional descriptive analysis suitable for quickly...... to arrange samples on the sheet) or the product (familiarisation with the sensory properties of the wines) improved the outcome compared to the classical Napping protocol. The classical Flash Profile protocol and its modified version including a Napping with subsequent attributes generation as the word...

  15. The systematic profiling of false identity documents: method validation and performance evaluation using seizures known to originate from common and different sources.

    Science.gov (United States)

    Baechler, Simon; Terrasse, Vincent; Pujol, Jean-Philippe; Fritz, Thibaud; Ribaux, Olivier; Margot, Pierre

    2013-10-10

    False identity documents constitute a potential powerful source of forensic intelligence because they are essential elements of transnational crime and provide cover for organized crime. In previous work, a systematic profiling method using false documents' visual features has been built within a forensic intelligence model. In the current study, the comparison process and metrics lying at the heart of this profiling method are described and evaluated. This evaluation takes advantage of 347 false identity documents of four different types seized in two countries whose sources were known to be common or different (following police investigations and dismantling of counterfeit factories). Intra-source and inter-sources variations were evaluated through the computation of more than 7500 similarity scores. The profiling method could thus be validated and its performance assessed using two complementary approaches to measuring type I and type II error rates: a binary classification and the computation of likelihood ratios. Very low error rates were measured across the four document types, demonstrating the validity and robustness of the method to link documents to a common source or to differentiate them. These results pave the way for an operational implementation of a systematic profiling process integrated in a developed forensic intelligence model.

  16. Multivariate Analysis of Effects of Asthmatic Patient Respiratory Profiles on the In Vitro Performance of a Reservoir Multidose and a Capsule-Based Dry Powder Inhaler.

    Science.gov (United States)

    Buttini, Francesca; Pasquali, Irene; Brambilla, Gaetano; Copelli, Diego; Alberi, Massimiliano Dagli; Balducci, Anna Giulia; Bettini, Ruggero; Sisti, Viviana

    2016-03-01

    The aim of this work was to evaluate the effect of two different dry powder inhalers, of the NGI induction port and Alberta throat and of the actual inspiratory profiles of asthmatic patients on in-vitro drug inhalation performances. The two devices considered were a reservoir multidose and a capsule-based inhaler. The formulation used to test the inhalers was a combination of formoterol fumarate and beclomethasone dipropionate. A breath simulator was used to mimic inhalatory patterns previously determined in vivo. A multivariate approach was adopted to estimate the significance of the effect of the investigated variables in the explored domain. Breath simulator was a useful tool to mimic in vitro the in vivo inspiratory profiles of asthmatic patients. The type of throat coupled with the impactor did not affect the aerodynamic distribution of the investigated formulation. However, the type of inhaler and inspiratory profiles affected the respirable dose of drugs. The multivariate statistical approach demonstrated that the multidose inhaler, released efficiently a high fine particle mass independently from the inspiratory profiles adopted. Differently, the single dose capsule inhaler, showed a significant decrease of fine particle mass of both drugs when the device was activated using the minimum inspiratory volume (592 mL).

  17. Antioxidant activity, phenolic-flavonoid content and high-performance liquid chromatography profiling of three different variants of Syzygium cumini seeds: A comparative study

    Science.gov (United States)

    Priya, Syama Hari; Prakasan, Nisha; Purushothaman, Jayamurthy

    2017-01-01

    Background: The medicinally important phytochemicals present in Syzygium cumini seeds probably accounts for its wide use in traditional systems of medicines in India, like Ayurveda, Unani, and Siddha. Aim: The aim of the study was to determine the antioxidant potential of three different geographical variants of S. cumini seeds and to compare the phenolic profiling to know the effect of geographical variation in phenolic composition. Materials and Methods: Total phenolic and flavonoid content of S. cumini seeds were analyzed. Antioxidant activities in terms of 2,2-diphenyl-1-picrylhydrazyl, 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid), nitric oxide and superoxide radical scavenging assays were performed. The most active fractions were subjected to high-performance liquid chromatography (HPLC) profiling to identify the phenolic composition. Results: Among all the fractions, 70% methanol fraction of S. cumini seed showed significant antioxidant potential. There existed a linear correlation between phenolic content and antioxidant activity. HPLC profiling of 70% methanol (ME) fractions of all the variants revealed the presence of phenolic compounds with high concentrations of ellagic acid and gallic acid. The differences in phenolic concentration due to geographical changes might be the reason for higher antioxidant potential showed by 70% ME of Trivandrum variant. Conclusion: 70% methanolic fraction of S. cumini can act as a novel source of natural antioxidant. PMID:28163968

  18. MPI Profiling

    Energy Technology Data Exchange (ETDEWEB)

    Han, D K; Jones, T R

    2005-02-11

    The Message Passing Interface (MPI) is the de facto message-passing standard for massively parallel programs. It is often the case that application performance is a crucial factor, especially for solving grand challenge problems. While there have been many studies on the scalability of applications, there have not been many focusing on the specific types of MPI calls being made and their impact on application performance. Using a profiling tool called mpiP, a large spectrum of parallel scientific applications were surveyed and their performance results analyzed.

  19. Comprehensive metabolite profiling of Plantaginis Semen using ultra high performance liquid chromatography with electrospray ionization quadrupole time-of-flight tandem mass spectrometry coupled with elevated energy technique.

    Science.gov (United States)

    Wang, Dandan; Qi, Meng; Yang, Qiming; Tong, Renchao; Wang, Rui; Bligh, S W Annie; Yang, Li; Wang, Zhengtao

    2016-05-01

    Plantaginis Semen is commonly used in traditional medicine to treat edema, hypertension, and diabetes. The commercially available Plantaginis Semen in China mainly comes from three species. To clarify the chemical composition and distinct different species of Plantaginis Semen, we established a metabolite profiling method based on ultra high performance liquid chromatography with electrospray ionization quadrupole time-of-flight tandem mass spectrometry coupled with elevated energy technique. A total of 108 compounds, including phenylethanoid glycosides, flavonoids, guanidine derivatives, terpenoids, organic acids, and fatty acids, were identified from Plantago asiatica L., P. depressa Willd., and P. major L. Results showed significant differences in chemical components among the three species, particularly flavonoids. This study is the first to provide a comprehensive chemical profile of Plantaginis Semen, which could be involved into the quality control, medication guide, and developing new drug of Plantago seeds.

  20. Traumatic intrusion of permanent teeth. Part 2. A clinical study of the effect of preinjury and injury factors, such as sex, age, stage of root development, tooth location, and extent of injury including number of intruded teeth on 140 intruded permanent teeth.

    Science.gov (United States)

    Andreasen, Jens Ove; Bakland, Leif K; Andreasen, Frances Meriam

    2006-04-01

    A prospective study of 140 intruded permanent teeth was done to evaluate the following healing complications: pulp necrosis (PN), root resorption (surface, inflammatory and replacement resorption) (RR) and defects in marginal periodontal healing (MA). These complications were related to various preinjury and injury factors. Age appeared to be related to all three healing complications in that patients younger than 12 years had the lowest complication rate. Stage of root formation at the time of the injury was very strongly related to PN and MA, with immature root formation (i.e. incomplete root formation or completed root formation with wide open apex) having better prognosis than more mature root development. Lateral incisors showed significantly more defects in MA, a finding possibly explained by the observation that lateral incisors were more often involved in multiple intrusions compared to other teeth and noting that multiple intrusions had a significantly higher frequency of MA. An associated crown fracture with exposed dentin resulted in more frequent PN, a finding possibly related to bacterial invasion through dentinal tubules into an ischemic pulp. The presence of a gingival laceration added to both PN and MA. The extent of intrusion (in mm) showed some relation to both RR with intrusion 1-3 mm having the lowest frequency of RR, whereas PN and MA showed no significant relation to the extent of intrusion. Finally, multiple adjacent intruded teeth were more frequently involved in a significantly greater loss of interproximal marginal bone (MA) than single intrusions. In conclusion, the relationship between healing complications and preinjury and injury factors could generally be explained by better healing possibilities in teeth with immature root formation. A possible explanation for that could be the softer bone surrounding the tooth, whereby trauma to the periodontium might be diminished.

  1. Insights on profiling of phorbol, deoxyphorbol, ingenol and jatrophane diterpene esters by high performance liquid chromatography coupled to multiple stage mass spectrometry.

    Science.gov (United States)

    Nothias-Scaglia, Louis-Félix; Schmitz-Afonso, Isabelle; Renucci, Franck; Roussi, Fanny; Touboul, David; Costa, Jean; Litaudon, Marc; Paolini, Julien

    2015-11-27

    This paper reports our effort to develop a comprehensive HPLC-MS(n)-based dereplication strategy for phorbol ester (PE), deoxyphorbol ester (dPE) and ingenol ester (IE) profiling in plant extracts. This strategy is composed of two sequential analysis exploiting specific hybrid triple quadrupole/linear ion trap instrument modes. A first run was performed using a multiple reaction monitoring (MRM) mode targeting fragmentation of PE and dPE/IE coupled with the acquisition of MS(2) spectrum for the ions at m/z 311 and m/z 313, respectively. A second run was then completed based on precursor ion scan mode (PIS) and automatic MS(2) acquisition for each quasimolecular ion. The developed approach was used to investigate ten Euphorbia extracts showing bioactivity against chikungunya virus replication. Experiments allowed partial annotation of three dPE/IE but no PE was detected. Results suggested that other types of diterpene esters displayed PE- and dPE/IE-like fragmentations. The study of jatrophane ester (JE) standards by CID fragmentation using low and high resolution mass spectrometry confirmed this hypothesis, highlighting challenges and difficulties of diterpene esters profiling within plant extracts. Nonetheless, the present LC-MS(n) method can be easily adapted to profile other types of diterpene esters.

  2. A study of the effects of the base doping profile on SiGe heterojunction bipolar transistor performance for all levels of injection

    Science.gov (United States)

    Khanduri, Gagan; Panwar, Brishbhan

    2006-04-01

    The effects of two different base doping profiles on the current gain and cut-off frequency for all levels of current injection have been studied for NPN Si/SiGe/Si double heterojunction bipolar transistors (SiGe DHBTs). The two-dimensional simulation results for a SiGe DHBT with uniform base doping and a fixed base Gummel number are compared with a non-uniform base doping profile SiGe drift-DHBT device. The study explains the performance of SiGe HBTs at different injection levels by analysing the electron and hole mobility, drift velocity, electric field, junction capacitances and intrinsic and extrinsic base region conductivities. The base doping profile in the SiGe drift-DHBT is controlled in such a way that it creates a net accelerating drift field in the quasi-neutral base for minority electrons. This accelerating field subsequently improves the current gain and cut-off frequency for the SiGe drift-DHBT in comparison with the SiGe DHBT for all levels of injection.

  3. Chemical fingerprint and metabolic profile analysis of ethyl acetate fraction of Gastrodia elata by ultra performance liquid chromatography/quadrupole-time of flight mass spectrometry.

    Science.gov (United States)

    Tang, Chunlan; Wang, Li; Liu, Xinxin; Cheng, Mengchun; Xiao, Hongbin

    2016-02-01

    The chemical fingerprint and metabolic profile of traditional Chinese medicine is very complicated and has been a great challenge. In the present study, chemical fingerprint of ethyl acetate fraction of Gastrodia elata (EtAcGE) and metabolic profile of rat plasma sample after intragastric administration of EtAcGE (2.5g/kg) were investigated using ultra-high performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry (UPLC/Q-TOF MS). A total of 38 chemical constituents of EtAcGE were identified by comparing their retention time, accurate molecular mass and characteristic fragment ions with those of references, or tentatively characterized by comparing molecular formula, fragment ions with that of known compound or information available in literature. And 40 compounds were detected in dosed rat plasma sample, including 16 prototypes and 24 metabolites underwent metabolic process of glucuronidation, glucosylation, sulfation, methylation, hydroxylation, dehydrogenation or mixed modes. The metabolic "soft spots" was hydroxyl or carboxy group. This is the first research for chemical fingerprint and metabolic profile of EtAcGE, which lay a foundation for the further investigation of EtAcGE.

  4. Performance, Carcass Quality and Fatty Acid Profile of Crossbred Wagyu Beef Steers Receiving Palm and/or Linseed Oil.

    Science.gov (United States)

    Suksombat, Wisitiporn; Meeprom, Chayapol; Mirattanaphrai, Rattakorn

    2016-10-01

    The objective of this study was to determine the effect of palm and/or linseed oil (LSO) supplementation on carcass quality, sensory evaluation and fatty acid profile of beef from crossbred Wagyu beef steers. Twenty four fattening Wagyu crossbred beef steers (50% Wagyu), averaging 640±18 kg live weight (LW) and approximately 30 mo old, were stratified and randomly assigned in completely randomized design into 3 treatment groups. All steers were fed approximately 7 kg/d of 14% crude protein concentrate with ad libitum rice straw and had free access to clean water and were individually housed in a free-stall unit. The treatments were i) control concentrate plus 200 g/d of palm oil; ii) control concentrate plus 100 g/d of palm oil and 100 g/d of LSO, iii) control concentrate plus 200 g/d of LSO. This present study demonstrated that supplementation of LSO rich in C18:3n-3 did not influence feed intakes, LW changes, carcass and muscle characteristics, sensory and physical properties. LSO increased C18:3n-3, C22:6n-3, and n-3 polyunsaturated fatty acids (PUFA), however, it decreased C18:1t-11, C18:2n-6, cis-9, trans-11, and trans-10,cis-12 conjugated linoleic acids, n-6 PUFA and n-6:n-3 ratio in Longissimus dorsi and Semimembranosus muscles.

  5. Dependence of recycling and edge profiles on lithium evaporation in high triangularity, high performance NSTX H-mode discharges

    Energy Technology Data Exchange (ETDEWEB)

    Maingi, R., E-mail: rmaingi@pppl.gov [Princeton Plasma Physics Laboratory, Receiving 3, Route 1 North, Princeton, NJ 08543 (United States); Osborne, T.H. [General Atomics, 3550 General Atomics Ct., San Diego, CA 92121 (United States); Bell, M.G.; Bell, R.E.; Boyle, D.P. [Princeton Plasma Physics Laboratory, Receiving 3, Route 1 North, Princeton, NJ 08543 (United States); Canik, J.M. [Oak Ridge National Laboratory, PO Box 2008, Oak Ridge, TN 37831 (United States); Diallo, A.; Kaita, R.; Kaye, S.M.; Kugel, H.W.; LeBlanc, B.P. [Princeton Plasma Physics Laboratory, Receiving 3, Route 1 North, Princeton, NJ 08543 (United States); Sabbagh, S.A. [Applied Physics and Applied Math Dept., Columbia University, New York, NY 10027 (United States); Skinner, C.H. [Princeton Plasma Physics Laboratory, Receiving 3, Route 1 North, Princeton, NJ 08543 (United States); Soukhanovskii, V.A. [Lawrence Livermore National Laboratory, 7000 East Ave, PO Box 808, Livermore, CA 94551 (United States)

    2015-08-15

    In this paper, the effects of a pre-discharge lithium evaporation variation on highly shaped discharges in the National Spherical Torus Experiment (NSTX) are documented. Lithium wall conditioning (‘dose’) was routinely applied onto graphite plasma facing components between discharges in NSTX, partly to reduce recycling. Reduced D{sub α} emission from the lower and upper divertor and center stack was observed, as well as reduced midplane neutral pressure; the magnitude of reduction increased with the pre-discharge lithium dose. Improved energy confinement, both raw τ{sub E} and H-factor normalized to scalings, with increasing lithium dose was also observed. At the highest doses, we also observed elimination of edge-localized modes. The midplane edge plasma profiles were dramatically altered, comparable to lithium dose scans at lower shaping, where the strike point was farther from the lithium deposition centroid. This indicates that the benefits of lithium conditioning should apply to the highly shaped plasmas planned in NSTX-U.

  6. Impactful study of dual work function, underlap and hetero gate dielectric on TFET with different drain doping profile for high frequency performance estimation and optimization

    Science.gov (United States)

    Yadav, Dharmendra Singh; Sharma, Dheeraj; Raad, Bhagwan Ram; Bajaj, Varun

    2016-08-01

    This manuscript presents a comparative study of different combination for the dual workfunction gate material, underlap and hetero gate dielectric tunnel field-effect transistors (TFET's). Their performances have been analyzed in terms of ON-state current, ambipolar behaviour and RF response along with different drain doping profile. For this, the Dual work function of gate provides enhancement in ON-state current by reducing the tunnel barrier width at source/channel interface. Whereas, the underlap of gate is done near to the drain region, helps in reduction of ambipolar conduction by creating deficiency of hole for the conduction, which is major hurdle for TFET. Further, the combinations of the dual workfunction and underlap give combine advantages of both such as improve ON-state current and suppressed ambipolar current. Apart from this, the combination of hetero gate dielectric dual workfunction under lapping leads to superior device performance in terms of ON-state current and ambipolar behaviour. The use of hetero gate dielectric and Gaussian doping profile with gate underlap reduces the gate to drain capacitance that also improves the RF parameters of the device.

  7. Effects of Profile, Religiosity and Job Attitude on the Job Performance of the Philippine National Police: The Case of Bulacan Province

    Directory of Open Access Journals (Sweden)

    Romeo D.C. Inasoria

    2014-10-01

    Full Text Available The Philippine National Police in the Province of Bulacan continuously update and enrich themselves to ensure peace and order in the province by reviewing the police operational procedures. Reform programs take place and seek to address the ills of society and the root causes of insurgency. Dynamic program actions are further reinforced by activities and projects towards capability building. Various programs had been develop in order to uplift the moral status of the police. But despite of these undertakings, there are still police officers who engage themselves in corruption and unethical practices. Hence, this research tries to look into a way to understand the relationship between the profile, religiosity, job attitude and job performance of the Philippine National Police in the Province of Bulacan. The respondents of this study consist ofthree hundred and ten (310 Police Non-Commissioned Officers (PNCO assigned in twenty-one (21 Municipal Police Stations,three (3 City Police Stations, the Provincial Head Quarter and provincial Public Safety Company.Using a descriptive-correlation survey method, the researcher believes to find the link between and among the variables. The findings of the study proved that there is a correlation in the profiles, level of religiosity and job attitude of the respondents to job performance Conclusion and recommendation are also presented in the paper.

  8. Nontargeted LC–MS Metabolomics Approach for Metabolic Profiling of Plasma and Urine from Pigs Fed Branched Chain Amino Acids for Maximum Growth Performance

    DEFF Research Database (Denmark)

    Assadi Soumeh, Elham; Hedemann, Mette Skou; Poulsen, Hanne Damgaard

    2016-01-01

    The metabolic response in plasma and urine of pigs when feeding an optimum level of branched chain amino acids (BCAAs) for best growth performance is unknown. The objective of the current study was to identify the metabolic phenotype associated with the BCAAs intake level that could be linked...... to the animal growth performance. Three dose–response studies were carried out to collect blood and urine samples from pigs fed increasing levels of Ile, Val, or Leu followed by a nontargeted LC–MS approach to characterize the metabolic profile of biofluids when dietary BCAAs are optimum for animal growth....... Results showed that concentrations of plasma hypoxanthine and tyrosine (Tyr) were higher while concentrations of glycocholic acid, tauroursodeoxycholic acid, and taurocholic acid were lower when the dietary Ile was optimum. Plasma 3-methyl-2-oxovaleric acid and creatine were lower when dietary Leu...

  9. Densification behavior, doping profile and planar waveguide laser performance of the tape casting YAG/Nd:YAG/YAG ceramics

    Science.gov (United States)

    Ge, Lin; Li, Jiang; Qu, Haiyun; Wang, Juntao; Liu, Jiao; Dai, Jiawei; Zhou, Zhiwei; Liu, Binglong; Kou, Huamin; Shi, Yun; Wang, Zheng; Pan, Yubai; Gao, Qingsong; Guo, Jingkun

    2016-10-01

    The sintering behavior and doping concentration profile of the planar waveguide YAG/Nd:YAG/YAG ceramics by the tape casting and solid-state reaction method were investigated on the basis of densification trajectory, microstructure evolution, and Nd3+ ions diffusion. The porosity of the green body by tape casting and cold isostatic pressing is about 38.6%. And the green bodies were consolidated from 1100 °C to 1800 °C for 0.5-20 h to study the densification and the doping diffusion behaviors. At the temperature higher than 1500 °C, pure YAG phase is formed, followed by the densification and grain growth process. With the increase of temperature, two sintering stages occur, corresponding to remarkable densification and significant grain growth, respectively. The mechanism controlling densification at 1550 °C is grain boundary diffusion. The diffusion of Nd3+ ions is more sensitive to temperature than the sintering time, and the minimum temperature required for the obvious diffusion of Nd3+ ions is higher than 1700 °C. Finally, planar waveguide YAG/1.5 at.%Nd:YAG/YAG transparent ceramics with in-line transmittance of 84.8% at 1064 nm were obtained by vacuum-sintering at 1780 °C for 30 h. The fluorescence lifetime of 4F3/2 state of Nd3+ in the specimen is about 259 μs. The prepared ceramic waveguide was tested in a laser amplifier and the laser pulse was amplificated from 87 mJ to 238 mJ, with the pump energy of 680 mJ.

  10. Effects of feeding dry glycerin to early postpartum Holstein dairy cows on lactational performance and metabolic profiles.

    Science.gov (United States)

    Chung, Y-H; Rico, D E; Martinez, C M; Cassidy, T W; Noirot, V; Ames, A; Varga, G A

    2007-12-01

    Effects of feeding a dry glycerin product (minimal 65% of food grade glycerol, dry powder) to 39 multiparous Holstein dairy cows (19 control and 20 glycerin-supplemented; lactation number = 2.2 +/- 1.3 SD) on feed intake, milk yield and composition, and blood metabolic profiles were investigated. Dry glycerin was fed at 250 g/d as a top dressing (corresponding to 162.5 g of glycerol/d) to the common lactating total mixed ration from parturition to 21 d postpartum. Individual milk was sampled from 2 consecutive milkings weekly and analyzed for components. Blood was sampled from the coccygeal vein at 4, 7, 14, and 21 (+/-0.92, pooled SD) d in milk and analyzed for urea nitrogen, glucose, insulin, nonesterified fatty acids, and beta-hydroxybutyrate. Urine was tested for the acetoacetate level weekly by using Ketostix. Average feed intake, milk yield and components, blood metabolites, and serum insulin concentrations were not affected by dry glycerin supplementation. Glycerin-supplemented cows experienced a more positive energy status (higher concentrations of plasma glucose, lower concentrations of plasma beta-hydroxybutyrate, and lower concentrations of urine ketones), which was observed during the second week of lactation, suggesting that energy availability may have been improved. This glucogenic effect of dry glycerin did not result in an increase in feed intake or milk yield during the first 3 wk of lactation, likely because of the relatively less negative energy status of cows transitioning into lactation. The tendency toward higher milk yield for glycerin-supplemented cows during wk 6 of lactation (52 vs. 46 kg/d) after the supplementation period (dry glycerin was terminated at wk 3 of lactation) suggested a potential benefit of dry glycerin on subsequent milk production, perhaps through changes in metabolism, which requires further investigation.

  11. Development of a High Performance, Low Profile Translation Table with Wire Feedthrough for a Deep Space CubeSat

    Science.gov (United States)

    Few, Alex

    2016-01-01

    NEAScout, a 6U cubesat and secondary payload on NASA's EM-1, will use an 85 sq m solar sail to travel to a near-earth asteroid at about 1 Astronomical Unit (about 1.5 x 10(exp 8) km) for observation and reconnaissance1. A combination of reaction wheels, reaction control system, and a slow rotisserie roll about the solar sail's normal axis were expected to handle attitude control and adjust for imperfections in the deployed sail during the 2.5-year mission. As the design for NEAScout matured, one of the critical design parameters, the offset in the center of mass and center of pressure (CP/CM offset), proved to be sub-optimal. After significant mission and control analysis, the CP/CM offset was accommodated by the addition of a new subsystem to NEAScout. This system, called the Active Mass Translator (AMT), would reside near the geometric center of NEAScout and adjust the CM by moving one portion of the flight system relative to the other. The AMT was given limited design space - 17 mm of the vehicle's assembly height-and was required to generate +/-8 cm by +/-2 cm translation to sub-millimeter accuracy. Furthermore, the design must accommodate a large wire bundle of small gage, single strand wire and coax cables fed through the center of the mechanism. The bend radius, bend resistance, and the exposure to deep space environment complicates the AMT design and operation and necessitated a unique design to mitigate risks of wire bundle damage, binding, and cold-welding during operation. This paper will outline the design constraints for the AMT, discuss the methods and reasoning for design, and identify the lessons learned through the designing, breadboarding and testing for the low-profile translation stages with wire feedthrough capability.

  12. EFFECT OF INVOLUTE CONTACT RA TIO ON THE DYNAMIC PERFORM ANCE OF SPUR GEAR WITH NO TOOTH PROFILE MODIFICATION

    Institute of Scientific and Technical Information of China (English)

    Wang Jianhong; Zhang Qingwei; Ren Hengbin

    2003-01-01

    The effect of involute contact ratio on the torsional vibration behavior of spur gear-pair is studied analytically through a mass-spring model. The tooth stiffness in model not only has a relation with time, as many prior studies presented, but, more important, with involute contact ratio (ICR) as well. The ICR embodies its impact on the spur gear's dynamic performance through changing the proportion of tooth stiffness when there are n+l teeth in contact to tooth stiffness when there are n teeth in contact. A couple of curves about impact of ICR on the gear's dynamic performance are presented, and they clearly demonstrate that the model can accurately describe the effects of ICR on dynamic transmission error. Finally, some conclusions useful to reduce vibration and noise of gear-pair are proposed.

  13. Neurocognitive performance and symptom profiles of Spanish-speaking Hispanic athletes on the ImPACT test.

    Science.gov (United States)

    Ott, Summer; Schatz, Philip; Solomon, Gary; Ryan, Joseph J

    2014-03-01

    This study documented baseline neurocognitive performance of 23,815 athletes on the Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) test. Specifically, 9,733 Hispanic, Spanish-speaking athletes who completed the ImPACT test in English and 2,087 Hispanic, Spanish-speaking athletes who completed the test in Spanish were compared with 11,955 English-speaking athletes who completed the test in English. Athletes were assigned to age groups (13-15, 16-18). Results revealed a significant effect of language group (p speaking athletes completing the test in Spanish scored more poorly than Spanish-speaking and English-speaking athletes completing the test in English, on all Composite scores and Total Symptom scores. Spanish-speaking athletes completing the test in English also performed more poorly than English-speaking athletes completing the test in English on three Composite scores. These differences in performance and reported symptoms highlight the need for caution in interpreting ImPACT test data for Hispanic Americans.

  14. [A profile of requirements for the performance of work related medical rehabilitation from the perspective of the statutory pension insurance].

    Science.gov (United States)

    Streibelt, M; Buschmann-Steinhage, R

    2011-06-01

    Work-related medical rehabilitation (Work MR) is a specific part of medical rehabilitation, which is well-established and broadly investigated. In almost all indications there is evidence of benefit of Work MR in patients with distinctive work-related problems due to chronic disease or disability. Nevertheless, there is a lack of implementation in clinical practice. This is due to a variety of reasons, mainly a missing definition of the appropriate Work MR interventions. The development of a Profile of Requirements (PoR) for defining contents and patterns of Work MR on behalf of the Statutory Pension Insurance (SPI) therefore is a fundamental step towards evidence-based, needs-focused rehabilitation management. The article introduces such a PoR - for the present focused on somatic indications. The PoR was developed by an SPI expert group and revised in an extensive discourse within the SPI. A strategy involved in this context was the dissemination of work-related therapeutical concepts in medical rehabilitation. In the PoR, Work MR is defined as a concrete work-related designing of therapeutical interventions as well as an integrated "philosophy" in thinking and practicing of the actors involved. Work MR is differentiated in 3 intervention levels: While work-related basic interventions (Level A) are provided in all facilities for all patients, core interventions (Level B) as well as specific interventions (Level C) are explicitly concentrated on patient subgroups with distinct work-related problems. In the PoR the relevant diagnostic and therapeutic work-related interventions are attributed to the different intervention levels and described concerning the concrete arrangement. The 3 central core interventions "Work-related psychological group interventions", "Work-related internal load test" and "Work conditioning" are presented. The decisive benefit of the PoR is to substantiate the requirements of Work MR on behalf of the SPI often worded in a rather unspecific

  15. 92-Gene molecular profiling in identification of cancer origin: a retrospective study in Chinese population and performance within different subgroups.

    Directory of Open Access Journals (Sweden)

    Fei Wu

    Full Text Available BACKGROUND: After cancer diagnosis, therapy for the patient is largely dependent on the tumor origin, especially when a metastatic tumor is being treated. However, cases such as untypical metastasis, poorly differentiated tumors or even a limited number of tumor cells may lead to challenges in identifying the origin. Moreover, approximately 3% to 5% of total solid tumor patients will not have to have their tumor origin identified in their lifetime. The THEROS CancerTYPE ID® is designed for identifying the tumor origin with an objective, rapid and standardized procedure. METHODOLOGY AND PRINCIPAL FINDINGS: This is a blinded retrospective study to evaluate performance of the THEROS CancerTYPE ID® in a Chinese population. In total, 184 formalin-fixed paraffin-embedded (FFPE samples of 23 tumor origins were collected from the tissue bank of Fudan University Shanghai Cancer Center (FDUSCC. A standard tumor cell enrichment process was used, and the prediction results were compared with reference diagnosis, which was confirmed by two experienced pathologists at FDUSCC. All of the 184 samples were successfully analyzed, and no tumor specimens were excluded because of sample quality issues. In total, 151 samples were correctly predicted. The agreement rate was 82.1%. A Pearson Chi-square test shows that there is no difference between this study and the previous evaluation test performed by bioTheranostics Inc. No statistically significant decrease was observed in either the metastasis group or tumors with high grades. CONCLUSIONS: A comparable result with previous work was obtained. Specifically, specimens with a high probability score (>0.85 have a high chance (agreement rate = 95% of being correctly predicted. No performance difference was observed between primary and metastatic specimens, and no difference was observed among three tumor grades. The use of laser capture micro-dissection (LCM makes the THEROS CancerTYPE ID® accessible to almost all

  16. Rhesus factor modulation of effects of smoking and age on psychomotor performance, intelligence, personality profile, and health in Czech soldiers.

    Directory of Open Access Journals (Sweden)

    Jaroslav Flegr

    Full Text Available BACKGROUND: Rhesus-positive and rhesus-negative persons differ in the presence-absence of highly immunogenic RhD protein on the erythrocyte membrane. This protein is a component of NH(3 or CO(2 pump whose physiological role is unknown. Several recent studies have shown that RhD positivity protects against effects of latent toxoplasmosis on motor performance and personality. It is not known, however, whether the RhD phenotype modifies exclusively the response of the body to toxoplasmosis or whether it also influences effects of other factors. METHODOLOGY/PRINCIPAL FINDINGS: In the present cohort study, we searched for the effects of age and smoking on performance, intelligence, personality and self-estimated health and wellness in about 3800 draftees. We found that the positive effect of age on performance and intelligence was stronger in RhD-positive soldiers, while the negative effect of smoking on performance and intelligence was of similar size regardless of the RhD phenotype. The effect of age on four Cattell's personality factors, i.e., dominance (E, radicalism (Q(1, self-sentiment integration (Q(3, and ergic tension (Q(4, and on Cloninger's factor reward dependency (RD was stronger for RhD-negative than RhD-positive subjects, while the effect of smoking on the number of viral and bacterial diseases was about three times stronger for RhD-negative than RhD-positive subjects. CONCLUSIONS: RhD phenotype modulates the influence not only of latent toxoplasmosis, but also of at least two other potentially detrimental factors, age and smoking, on human behavior and physiology. The negative effect of smoking on health (estimated on the basis of the self-rated number of common viral and bacterial diseases in the past year was much stronger in RhD-negative than RhD-positive subjects. It is critically needed to confirm the differences in health response to smoking between RhD-positive and RhD-negative subjects by objective medical examination in

  17. Vision-based precision inspection system for profile and performance of small and micro gears using the intelligent image processing techniques and virtual master gears

    Science.gov (United States)

    Pahk, Heui Jae; Hwang, Young Min; Lee, Il Hwan; Ahn, Woo Jung

    2000-10-01

    As the product size become smaller, much smaller sized parts are increasingly required in many products fabrication such as cameras, camcorders, and electric appliances, etc. Small or micro gears whose sizes are about few hundred micrometers to few millimeters have been greatly required for the above products, as they become most efficient parts for power transmission. The small of micro gears are prone to geometrical and functioning inaccuracy during the micro fabrication processes, and thus the measurement system has been desired for the geometry and performance checking of gears. In this paper, a precision inspection system is developed for the gear checking, consisting of the optical vision microscope, vision image processing modules with subpixel accuracy, and the profile inspection software using the virtual master jigs/gears mathematically generated. For accurate analysis of the gear geometry from the captured gear image through the optical vision system, a highly accurate vision image processing algorithm has been implemented, where two dimensional subpixelling technique is developed having about one tenth subpixel accuracy. A mathematically generated mater gears/jigs are implemented: several core parameters of the gear profile are calculated from the comparison between the virtual master and the measured gears. Virtual precision ball jigs are simulated between gear teeth profile, and thus the runout parameter can be successfully evaluated from the virtual jig movement on the gear teeth image. The eccentricity parameters can also be calculated from the sinusoidal fitting of the virtual ball movement. The development precision inspection system for small or micro gears has been applied to practical gears of various range, and the essential gear parameters are successfully measured with sub micrometer accuracy.

  18. Effect of unsaturated fatty acid supplementation on performance and milk fatty acid profile in dairy cows fed a high fibre diet

    Directory of Open Access Journals (Sweden)

    Severino Segato

    2010-01-01

    Full Text Available The influence of unsaturated fatty acid (UFA supplement on productive performance, physiochemical properties and fatty acid (FA profile of milk, was investigated in lactating dairy cows fed with high fibre diets. According to a cross-over design, twelve cows were assigned to two experimental settings characterized by different FA profiles. Cows received a high fibre diet (~42% NDF on DM basis supplemented with soybean based mixtures with these FA compositions: 92.0% of saturated FA (SFA, 2.8% of monounsaturated FA (MUFA and 5.2% of polyunsaturated FA (PUFA in the control diet (C-diet; 19.1% of SFA, 20.9% of MUFA and 60.0% of PUFA in the experimental diet (E-diet. The E-diet did not affect dry matter intake nor milk yield. Milk composition and coagulation traits resulted similar between treatments, except for the lactose level, which was lower in the E-diet (5.0 vs 4.8%; P<0.05 and the freezing point (-0.546 vs -0.535 °C; P<0.05. As respects the milk FA profile, the E-diet significantly increased the percentage of UFA because of their greater amount in the ration; however the “transfer” of UFA in milk was limited by the high level of FA biohydrogenation (BH at the ruminal level. UFA showed low values of carry over in milk (67.5 vs 39.7%; P<0.001 due to the saturation process; on the contrary SFA had a threefold increment (124 vs 323%; P<0.001, mostly due to a peak in the production of stearic acid. In this study, the percentage of CLA in milk (0.50 vs 0.62%; P<0.05 was quite low for both diets, if compared with other studies, and this was probably due to a low vaccenic acid supply at duodenal level.

  19. The age-gender-status profile of high performing athletes in the UK taking nutritional supplements: Lessons for the future

    Directory of Open Access Journals (Sweden)

    Naughton Declan P

    2008-01-01

    Full Text Available Abstract Background Owing to the mechanics of anti-doping regulation via the World Anti-Doping Agency's Prohibited List, nutritional supplement use received little attention in comparison to the prevalence of doping. The aims of this study were to investigate supplement use, identify groups of athletes with high levels of supplement use and the prevalence of concomitant use of supplements. Methods Survey data from 847 high-performing athletes in the UK were analysed using descriptive statistics. The survey, conducted by UK Sport, consisted of questions regarding knowledge of the prohibited substances, testing procedure, nutritional supplement use and perceptions of the doping problem. The proportion of supplement users and the relative use of each supplement were compared by age, gender and professional status. Results Among 874 high-performing athletes in the UK sample, 58.8% of them reported the use of at least one nutritional supplement. Among supplement users, 82.6% used more than one and 11.5% reported use of more than five nutritional supplements. Of the 9 supplements listed, multivitamins (72.6% and vitamin C (70.7% were used most, followed by creatine (36.1%, whey protein (31.7%, echinacea (30.9%, iron (29.9% and caffeine (23.7%. Less than 11% reported the use of magnesium or ginseng. Creatine use was typically associated with males regardless of status and across all ages, whereas iron was characteristically used by females. A 'typical' supplement user is male, between 24 and 29 years of age, involved in professional sport and using a combination of supplements. Male professional players between age 30 and 34 years, and female non-professional athletes between 24 and 29 years of age also represented a considerable proportion of supplement users. Athletes older than 40 years of age were practically non-users. Concomitant use of supplements is characteristic of male users more than females. Conclusion As supplement use has been previously

  20. 2012 ARPA-E Energy Innovation Summit: Profiling Foro Energy: High Power Lasers - Long Distances (Performer Video)

    Energy Technology Data Exchange (ETDEWEB)

    None Available

    2012-02-28

    The third annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2012. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. A few videos were selected for showing during the Summit to attendees. These 'performer videos' highlight innovative research that is ongoing and related to the main topics of the Summit's sessions. Featured in this video from Foro Energy are Joel Moxley, Founder and CEO, Mark Zediker, Founder and CTO, and Paul Deutch, President and COO. Steven Chu, Secretary of Energy, also appears briefly in this video to praise the accomplishment of a high powered laser that can transmit that power long distances for faster and more powerful drilling of geothermal, oil, and gas wells.

  1. Classifying Schizophrenia Using Multimodal Multivariate Pattern Recognition Analysis: Evaluating the Impact of Individual Clinical Profiles on the Neurodiagnostic Performance.

    Science.gov (United States)

    Cabral, Carlos; Kambeitz-Ilankovic, Lana; Kambeitz, Joseph; Calhoun, Vince D; Dwyer, Dominic B; von Saldern, Sebastian; Urquijo, Maria F; Falkai, Peter; Koutsouleris, Nikolaos

    2016-07-01

    Previous studies have shown that structural brain changes are among the best-studied candidate markers for schizophrenia (SZ) along with functional connectivity (FC) alterations of resting-state (RS) patterns. This study aimed to investigate effects of clinical and sociodemographic variables on the classification by applying multivariate pattern analysis (MVPA) to both gray matter (GM) volume and FC measures in patients with SZ and healthy controls (HC). RS and structural magnetic resonance imaging data (sMRI) from 74 HC and 71 SZ patients were obtained from a Mind Research Network COBRE dataset available via COINS (http://coins.mrn.org/dx). We used a MVPA framework using support-vector machines embedded in a repeated, nested cross-validation to generate a multi-modal diagnostic system and evaluate its generalizability. The dependence of neurodiagnostic performance on clinical and sociodemographic variables was evaluated. The RS classifier showed a slightly higher accuracy (70.5%) compared to the structural classifier (69.7%). The combination of sMRI and RS outperformed single MRI modalities classification by reaching 75% accuracy. The RS based moderator analysis revealed that the neurodiagnostic performance was driven by older SZ patients with an earlier illness onset and more pronounced negative symptoms. In contrast, there was no linear relationship between the clinical variables and neuroanatomically derived group membership measures. This study achieved higher accuracy distinguishing HC from SZ patients by fusing 2 imaging modalities. In addition the results of RS based moderator analysis showed that age of patients, as well as their age at the illness onset were the most important clinical features.

  2. Changes in repeated-sprint performance in relation to change in locomotor profile in highly-trained young soccer players.

    Science.gov (United States)

    Buchheit, Martin; Mendez-Villanueva, Alberto

    2014-01-01

    The aim of this study was to examine the effects of changes in maximal aerobic (MAS) and sprinting (MSS) speeds and the anaerobic reserve (ASR) on repeated-sprint performance. Two hundred and seventy highly-trained soccer players (14.5 ± 1.6 year) completed three times per season (over 5 years) a maximal incremental running test to approach MAS, a 40-m sprint with 10-m splits to assess MSS and a repeated-sprint test (10 × 30-m sprints), where best (RSb) and mean (RSm) sprint times, and percentage of speed decrement (%Dec) were calculated. ASR was calculated as MSS-MAS. While ∆RSb were related to ∆MSS and ∆body mass (r(2) = 0.42, 90%CL[0.34;0.49] for the overall multiple regression, n = 334), ∆RSm was also correlated with ∆MAS and ∆sum of 7 skinfolds (r(2) = 0.43 [0.35;0.50], n = 334). There was a small and positive association between ∆%Dec and ∆MAS (r(2) = 0.02 [-0.07;0.11], n = 334). Substantial ∆MSS and ∆MAS had a predictive value of 70 and 55% for ∆RSm, respectively. Finally, ∆ASR per se was not predictive of ∆RSm (Cohen's = +0.8 to -0.3 with increased ASR), but the greater magnitude of ∆RSm improvement was observed when MSS, MAS and ASR increased together (0.8 vs. +0.4 with ASR increased vs. not, additionally to MSS and MAS). Low-cost field tests aimed at assessing maximal sprinting and aerobic speeds can be used to monitor ∆RS performance.

  3. Organizational Profile, HR Practices And The Perceived Quality And Performance Of Small Businesses: Empirical Highlights From The Urban Child Care Centers

    Directory of Open Access Journals (Sweden)

    M. Ruhul Amin

    2011-02-01

    Full Text Available This paper examines the relationships among the organizational profile, the human resource practices, and the quality and profitability of private childcare centers of a large metropolis. Organizational profile variables included: size (measured in terms of total FTE employees, age (measured in terms of number of years in service, HR practices included: empowerment and enrichment strategies, benefits, grievances, affirmative action, promotion, supervision, participation in decision-making, and the like. Quality is a variable reflecting the perception of service relative to the population of similar centers. It also includes the application of quality concepts such as benchmarking, and continuous improvement. The organizational performance includes such variables as perceived relative profitability, annual revenues, and behavioral measures of employees (i.e., motivation, morale, commitment, trust, turnover, and job satisfaction. Data was collected as a pilot project in 2001 through a mail questionnaire as well as through personal interviews of the owners/directors of 70 (out of 200 selected private childcare centers of New York City. The findings of correlation and the regression analyses support a number of illustrative hypotheses pertaining to the association among the selected variables. The paper interpreted the finding in the light of existing organizational theories and concludes with a list of highlights (imperatives for the owner/directors of urban child care centers.

  4. Improved performance of analog and digital acousto-optic modulation with feedback under profiled beam propagation for secure communication using chaos

    Science.gov (United States)

    Almehmadi, Fares S.; Chatterjee, Monish R.

    2014-12-01

    Using intensity feedback, the closed-loop behavior of an acousto-optic hybrid device under profiled beam propagation has been recently shown to exhibit wider chaotic bands potentially leading to an increase in both the dynamic range and sensitivity to key parameters that characterize the encryption. In this work, a detailed examination is carried out vis-à-vis the robustness of the encryption/decryption process relative to parameter mismatch for both analog and pulse code modulation signals, and bit error rate (BER) curves are used to examine the impact of additive white noise. The simulations with profiled input beams are shown to produce a stronger encryption key (i.e., much lower parametric tolerance thresholds) relative to simulations with uniform plane wave input beams. In each case, it is shown that the tolerance for key parameters drops by factors ranging from 10 to 20 times below those for uniform plane wave propagation. Results are shown to be at consistently lower tolerances for secure transmission of analog and digital signals using parameter tolerance measures, as well as BER performance measures for digital signals. These results hold out the promise for considerably greater information transmission security for such a system.

  5. Effect of six Chinese spices on heterocyclic amine profiles in roast beef patties by ultra performance liquid chromatography-tandem mass spectrometry and principal component analysis.

    Science.gov (United States)

    Zeng, Maomao; He, Zhiyong; Zheng, Zongping; Qin, Fang; Tao, Guanjun; Zhang, Shuang; Gao, Yahui; Chen, Jie

    2014-10-01

    The effects of Chinese spices on the profiles of 17 heterocyclic amines (HAs) from seven HA categories were investigated in roast beef patties using Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS) and principal component analysis. Three groups of HAs, imidazopyridines (PhIP, DMIP, and 1,5,6-TMIP), imidazoquinoxalines (MeIQx and 4,8-DiMeIQx), and β-carbolines (harman and norharman), were detected and quantified in all of the samples. The results demonstrated that the total HA and imidazopyridine profiles could clearly be affected by 1% pricklyash peel (14.1 ± 0.76 and 6.06 ± 0.32 ng/g), chilli (41.0 ± 0.01 and 23.0 ± 0.52 ng/g), and cumin (59.9 ± 2.44 and 31.1 ± 3.06 ng/g), in comparison with control values of 21.8 ± 2.40 and 14.3 ± 2.04 ng/g, respectively. The difference was only significant (p spices in meat processing to minimize HA formation.

  6. Effect of exogenous fibrolytic enzymes on performance and blood profile in early and mid-lactation Holstein cows

    Directory of Open Access Journals (Sweden)

    Anja Peters

    2015-09-01

    Full Text Available The supplementation of exogenous fibrolytic enzymes (EFE to dairy cows diets could be a strategy to improve fiber degradation in the rumen which is especially important for the early lactating cows characterized by a high milk energy output and an insufficient energy intake. The objective of this study was to examine the effects of a fibrolytic enzyme product (Roxazyme G2 Liquid, 3.8 and 3.9 mL/kg total mixed ration [TMR] DM supplemented to a TMR on production performance and blood parameters of dairy cows during early (trial 1 and mid-lactation (trail 2. In addition, rumination activity was measured in trial 2. The nutrient digestibility of the experimental TMR was obtained by using wethers. In the digestibility trial, EFE was supplemented at a rate of 4.4 mL/kg Roxazyme G2 Liquid TMR-DM. The TMR contained 60% forage and 40% concentrate (DM basis. Twenty eight 50 ± 16 days in milk (DIM and twenty six 136 ± 26 DIM Holstein cows were used in two 8-wk completely randomized trails, stratified by parity and milk yield level. One milliliter of the enzyme product contained primarily cellulase and xylanase activities (8,000 units endo-1,4-ß glucanase, 18,000 units endo-1,3(4-ß glucanase and 26,000 units 1,4-ß xylanase. No differences in digestibility of DM, OM, CP, NDF and ADF were observed (P > 0.05 between the control and the EFE supplemented TMR. Addition of EFE to the TMR fed to early (trial 1 and mid-lactation cows (trial 2 did not affect daily dry matter intake (DMI, milk yield, 4% fat-corrected milk, energy-corrected milk (ECM, concentration of milk fat, protein, fat-protein-quotients, somatic cell score, energy balance, and gross feed efficiency of early and mid-lactation cows (P > 0.05. Mid-lactation cows (trial 2 fed with TMR enzyme showed a tendency of a slightly higher ECM yield (P = 0.09. The tested blood parameters were not affected by treatment in trials 1 and 2 (P > 0.05. Exogenous fibrolytic enzymes supplementation did not alter

  7. In Vitro Dosing Performance of the ELLIPTA® Dry Powder Inhaler Using Asthma and COPD Patient Inhalation Profiles Replicated with the Electronic Lung (eLung™).

    Science.gov (United States)

    Hamilton, Melanie; Leggett, Richard; Pang, Cheng; Charles, Stephen; Gillett, Ben; Prime, David

    2015-12-01

    To evaluate the in vitro dose delivery characteristics of approved asthma and chronic obstructive pulmonary disease (COPD) therapies delivered via the ELLIPTA(®) dry powder inhaler across inhalation endpoints representative of the target patient population, using the Electronic Lung (eLung™) to replicate inhaler-specific patient inhalation profiles that were previously recorded in vivo. Selected profiles, representative of the range of inhalation endpoints achieved by patients with all severities of asthma and COPD, were replicated using the eLung breathing simulator in conjunction with an oropharyngeal cast. A Next Generation Impactor was coupled to the eLung to determine the aerodynamic particle size distribution of the ex-throat dose (ETD) of asthma and COPD therapies delivered via the ELLIPTA inhaler. Delivered dose (DD), ETD, and fine particle dose (FPD; defined as a mass of active substance less than 5 μm) were determined for fluticasone furoate (FF)/vilanterol (VI) 100/25 μg and 200/25 μg (asthma and COPD), umeclidinium (UMEC)/VI 62.5/25 μg (COPD only), FF 100 μg and 200μg monotherapy (asthma only), and UMEC 62.5 μg monotherapy (COPD only). Inhalation profiles replicated by eLung covered a wide range of peak inspiratory flow rates (41.6-136.9 L/min), pressure drops (1.2-13.8 kPa), and inhaled volumes through the inhaler (0.7-4.2L). DD was consistent across the range of patient representative inhalation parameters for all components (FF, VI, and UMEC) of each therapy assessed; although ETD and FPD were also generally consistent, some small variation was observed. Dose delivery was consistent for each of the components, whether delivered as mono- or combination therapy. The in vitro performance of the ELLIPTA inhaler has been demonstrated for the delivery of FF/VI, UMEC/VI, FF monotherapy, and UMEC monotherapy. Across a range of inspiratory profiles, DD was consistent, while ETD and FPD showed little flow dependency.

  8. A metabolic profiling analysis of the nephrotoxicity of acyclovir in rats using ultra performance liquid chromatography/mass spectrometry.

    Science.gov (United States)

    Xing, Wenmin; Gu, Lili; Zhang, Xinyue; Xu, Jiadong; Lu, Hong

    2016-09-01

    Acyclovir (ACV) exposure is a common cause of acute kidney injury (AKI). The toxicity mechanism of ACV has always been a matter of debate. The present study investigated into the time-effect relationship and dose-effect relationship of ACV-induced nephrotoxicity in rats using metabonomics. Twenty-four rats were randomly divided into four groups: a 0.9% NaCl solution group, and 100, 300, and 600mg/kg ACV-treated groups; the ACV or vehicle solution was administered with a single intravenous injection. Urine was collected at different time periods (12h before administration, and 0-6h, 7-12h, and 13-24h after administration). Routine urinalysis was conducted by a urine automatic analyzer. Renal markers, including urine urea nitrogen, urine creatinine, and urinary N-acetyl-β-d-glucosaminidase (NAG) activity, were determined using established protocols. Urinary metabolites were evaluated using ultra performance liquid chromatography/mass spectrometry (UPLC/MS). In the ACV-treated rats, increased levels of protein (PRO), occult blood (BLD), white blood cell (WBC), and NAG activity in urine were observed, while the urine creatinine and urea nitrogen levels showed a decrease compared with the control. Moreover, urine metabolites significantly changed after the treatment with ACV, and all the effects induced by ACV were dose-time dependent. Finally, 4 metabolites (guanine, 4-guanidinobutyric acid, creatinine, and urea) were identified, which can be used for further research on the mechanism of ACV-induced nephrotoxicity.

  9. Phytochemical Profile of Erythrina variegata by Using High-Performance Liquid Chromatography and Gas Chromatography-Mass Spectroscopy Analyses.

    Science.gov (United States)

    Muthukrishnan, Suriyavathana; Palanisamy, Subha; Subramanian, Senthilkumar; Selvaraj, Sumathi; Mari, Kavitha Rani; Kuppulingam, Ramalingam

    2016-08-01

    Natural products derived from plant sources have been utilized to treat patients with numerous diseases. The phytochemical constituents present in ethanolic leaf extract of Erythrina variegata (ELEV) were identified by using high-performance liquid chromatography (HPLC) and gas chromatography-mass spectroscopy (GC-MS) analyses. Shade dried leaves were powdered and extracted with ethanol for analyses through HPLC to identify selected flavonoids and through GC-MS to identify other molecules. The HPLC analysis of ELEV showed the presence of gallic and caffeic acids as the major components at concentrations of 2.0 ppm and 0.1 ppm, respectively, as well as other components. GC-MS analysis revealed the presence of 3-eicosyne; 3,7,11,15-tetramethyl-2-hexadecen-1-ol; butanoic acid, 3-methyl-3,7-dimethyl-6-octenyl ester; phytol; 1,2-benzenedicarboxylic acid, diundecyl ester; 1-octanol, 2-butyl-; squalene; and 2H-pyran, 2-(7-heptadecynyloxy) tetrahydro-derivative. Because pharmacopuncture is a new evolving natural mode that uses herbal extracts for treating patients with various ailments with minimum pain and maximum effect, the results of this study are particularly important and show that ELEV possesses a wide range of phytochemical constituents, as indicated above, as effective active principle molecules that can be used individually or in combination to treat patients with various diseases.

  10. Phytochemical Profile of Erythrina variegata by Using High-Performance Liquid Chromatography and Gas Chromatography-Mass Spectroscopy Analyses

    Directory of Open Access Journals (Sweden)

    Suriyavathana Muthukrishnan

    2016-08-01

    Full Text Available Natural products derived from plant sources have been utilized to treat patients with numerous diseases. The phytochemical constituents present in ethanolic leaf extract of Erythrina variegata (ELEV were identified by using high-performance liquid chromatography (HPLC and gas chromatography-mass spectroscopy (GC-MS analyses. Shade dried leaves were powdered and extracted with ethanol for analyses through HPLC to identify selected flavonoids and through GC-MS to identify other molecules. The HPLC analysis of ELEV showed the presence of gallic and caffeic acids as the major components at concentrations of 2.0 ppm and 0.1 ppm, respectively, as well as other components. GC-MS analysis revealed the presence of 3-eicosyne; 3,7,11,15-tetramethyl-2-hexadecen-1-ol; butanoic acid, 3-methyl-3,7-dimethyl-6-octenyl ester; phytol; 1,2-benzenedicarboxylic acid, diundecyl ester; 1-octanol, 2-butyl-; squalene; and 2H-pyran, 2-(7-heptadecynyloxy tetrahydro-derivative. Because pharmacopuncture is a new evolving natural mode that uses herbal extracts for treating patients with various ailments with minimum pain and maximum effect, the results of this study are particularly important and show that ELEV possesses a wide range of phytochemical constituents, as indicated above, as effective active principle molecules that can be used individually or in combination to treat patients with various diseases.

  11. Performance and return-to-sport after ACL reconstruction in NFL quarterbacks.

    Science.gov (United States)

    Erickson, Brandon J; Harris, Joshua D; Heninger, Jacob R; Frank, Rachel; Bush-Joseph, Charles A; Verma, Nikhil N; Cole, Brian J; Bach, Bernard R

    2014-08-01

    Anterior cruciate ligament (ACL) rupture is a significant injury in National Football League (NFL) quarterbacks. The purpose of this study was to determine (1) return-to-sport (RTS) rate in NFL quarterbacks following ACL reconstruction, (2) performance upon RTS, and (3) the difference in RTS and performance between players who underwent ACL reconstruction and controls. Thirteen quarterbacks (14 knees) who met inclusion criteria underwent ACL reconstruction while in the NFL. Matched controls were selected from the NFL during the same time span to compare and analyze age, body mass index (BMI), position, performance, and NFL experience. Student t tests were performed for analysis of within- and between-group variables. Bonferroni correction was used in the setting of multiple comparisons. Twelve quarterbacks (13 knees; 92%) were able to RTS in the NFL. Mean player age was 27.2±2.39 years. Mean career length in the NFL following ACL reconstruction was 4.85±2.7 years. Only 1 player needed revision ACL reconstruction. In both cases and controls, player performance was not significantly different from preinjury performance after ACL reconstruction (or index year in controls). There was also no significant performance difference between case and control quarterbacks following ACL reconstruction (or index year in controls). There is a high rate of RTS in the NFL following ACL reconstruction. In-game performance following ACL reconstruction was not significantly different from preinjury or from controls. Copyright 2014, SLACK Incorporated.

  12. Profiling the indole alkaloids in yohimbe bark with ultra-performance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry.

    Science.gov (United States)

    Sun, Jianghao; Baker, Andrew; Chen, Pei

    2011-09-30

    An ultra-performance liquid chromatography/ion mobility quadrupole time-of-flight mass spectrometry (UPLC/IM-QTOF-MS) method was developed for profiling the indole alkaloids in yohimbe bark. Many indole alkaloids with the yohimbine or ajmalicine core structure, plus methylated, oxidized and reduced species, were characterized. Common fragments and mass differences are described. It was shown that the use of IMS could provide another molecular descriptor, i.e. molecular shape by rotationally averaged collision cross-section; this is of great value for identification of constituents when reference materials are usually not available. Using the combination of high resolution (~40000) accurate mass measurement with time-aligned parallel (TAP) fragmentation, MS(E) (where E represents collision energy), ion mobility mass spectrometry (IMS) and UPLC chromatography, a total 55 indole alkaloids were characterized and a few new indole alkaloids are reported for the first time.

  13. Quantitative profiling of retinyl esters in milk from different ruminant species by using high performance liquid chromatography-diode array detection-tandem mass spectrometry.

    Science.gov (United States)

    Rocchi, Silvia; Caretti, Fulvia; Gentili, Alessandra; Curini, Roberta; Perret, Daniela; Pérez-Fernández, Virginia

    2016-11-15

    An effective high performance liquid chromatography-diode array detection-tandem mass spectrometry (HPLC-DAD-MS/MS) analytical approach was developed for retinoid profiling in raw milk samples (cow, buffalo, ewe, and goat). The analytes were isolated by means of liquid-liquid extraction, including a "lipid freezing" step, with yields exceeding 66%. Since the positive atmospheric pressure chemical ionisation mass spectrometry (APCI-MS) detection is not completely selective, a reliable identification has been accomplished by fully separating the analytes on a tandem C18/C30 column system under non-aqueous reversed phase (NARP) chromatography conditions. After validation, different milk varieties obtained from pasture-fed animals were analysed, providing, for the first time, the retinoid composition of both buffalo's and ewe's milk. According to the literature, retinyl palmitate has been found to be the most abundant vitamin A vitamer, but retinyl oleate is the prevalent form in the caprine milk.

  14. Comparison of casein and whey in diets on performance, immune responses and metabolomic profile of weaning pigs challenged with E.coli F4

    DEFF Research Database (Denmark)

    Sugiharto, Sugiharto; Jensen, Bent Borg; Hedemann, Mette Skou

    2014-01-01

    The differences in amino acid composition in casein and whey have been thought to exert different immunomodulatory and metabolic effects. The objective of this study was to compare the effects of casein and whey on performance, immune responses and plasma metabolomic profile of weanling pigs...... challenged with E. coli F4. Two factorial experiments involving 24 weanling pigs were conducted. Diets containing casein or whey, and challenge with E. coli O149:F4 or not, were the two factors. Blood was sampled at the day before challenge and 4 and 7 days postchallenge. For measurement of mucosal immune...... responses and intestinal dimensions, samples were collected from the small intestine (SI) immediately after killing at 7 days postchallenge. Feeding the whey-diet decreased (P

  15. Effects on growth performance, carcass characteristics, and the fat and meat fatty acid profile of rabbits fed diets with chia (Salvia hispanica L.) seed supplements.

    Science.gov (United States)

    Peiretti, P G; Meineri, G

    2008-12-01

    The effects of three levels (0%, 10%, or 15%) of chia (Salvia hispanica L.) seed (SHS) included in the diet on the growth performance, some carcass characteristics and fatty acid profile of rabbit meat and perirenal fat was studied. At the end of the experiment, there were no significant differences among the groups in live weight, live weight gain, feed consumption, feed efficiency, carcass yield or the percentages of edible organs. The percentage values of hind legs, fore legs, loin and abdominal wall, breast and ribs, skin and limbs, and head were not affected by the inclusion level of SHS. The polyunsaturated fatty acid (PUFA) concentration in the longissimus dorsi muscle and perirenal fat was significantly increased with increasing SHS inclusion, while the saturated fatty acid (SFA) decreased. The n-6/n-3 PUFA ratio of the rabbit meat decreased from 4.55 in the control group, to 1.03 in the 15% SHS group.

  16. Serum hormone profiles, pregnancy rates, and offspring performance of Rambouillet ewes treated with recombinant bovine somatotropin before breeding.

    Science.gov (United States)

    Camacho, L E; Benavidez, J M; Hallford, D M

    2012-08-01

    An experiment was conducted to examine effects of bovine ST (bST) on serum hormone concentrations, pregnancy rates, and offspring performance. Before initiation of a fall breeding period, 75 Rambouillet ewes (68.8 ± 1.5 kg) received an intravaginal insert containing 0.3 g of progesterone (P4) to synchronize onset of estrus. After 12 d, inserts were removed (d 0), and ewes (stratified by BW and age) received either 0 (control, n = 37) or 250 (n = 38) mg of recombinant bST (Posilac, Monsanto, St. Louis, MO, subcutaneously). Ewes were joined with fertile rams 24 h after insert removal. Blood samples were collected from 12 ewes in each treatment group daily from d 0 to 20 after insert removal. Serum IGF-I concentrations were 315 and 437 (± 58) ng/mL in control and bST-treated ewes 2 d after receiving bST (P = 0.02) and remained increased (P 0.10) and estradiol (P = 0.65) were similar between treatments. Serum triiodothyronine (T3) and thyroxine (T4) concentrations were similar (P > 0.20) between treatments from d 0 through 8. Controls had greater (P 0.10) in control and bST-treated ewes from d 0 through 3 but was increased (P 0.10) between treatments from d 9 to 20. Serum insulin concentrations were 0.44 and 1.74 (± 0.19) ng/mL in control and bST-treated ewes, respectively, 1 d after receiving bST (P Pregnancy rates and offspring adjusted weaning weights were decreased by bST treatment immediately before breeding.

  17. Performance and metabolite profile of dairy cows fed tropical grasses and concentrates containing crude protein with low or high degradability

    Directory of Open Access Journals (Sweden)

    Raphael dos Santos Gomes

    Full Text Available ABSTRACT Ten Holstein-Zebu crossbred cows distributed into two simultaneous Latin squares (5 × 5 as a 2 × 2 factorial arrangement formed by chopped sugarcane or elephant grass silage, both with high or low protein degradability supplements and a corn silage as a control treatment, were compared using orthogonal contrasts. The studied variables were the performance, plasma concentrations of urea-N, glucose, and creatinine, urine-N and milk urea-N, and the nychthemeral variation in NH3-N in the rumen fluid of dairy cows. Nutrient intake, milk production, and milk composition were affected by the treatments. The total mixed ration containing elephant grass silage combined with rumen undegradable protein (RUP provided balanced amounts of carbon and nitrogen in the rumen. This effect may explain the 18% increase in milk yield compared with the other treatments. The diurnal pattern of ruminal NH3-N was interpreted with a sinusoid model. In general, cows fed elephant grass silage exhibited higher concentrations of blood plasma and milk urea-N than animals fed sugarcane. The cows that consumed elephant grass silage with rumen degradable protein concentrate showed a higher milk urea-N compared with animals that consumed elephant grass silage with the RUP concentrate. The use of diets based on corn silage leads to a better use of nitrogen compounds because these diets resulted in lower levels of urea-N in the plasma, urine, and milk at the same level of milk production compared with diets containing elephant grass silage or chopped sugarcane as roughages. In sugarcane-based diets, even greater nitrogen losses in the urine are observed, despite the presence of readily fermentable carbohydrates in the diet.

  18. Sonic spray ionization technology: performance study and application to a LC/MS analysis on a monolithic silica column for heroin impurity profiling.

    Science.gov (United States)

    Dams, Riet; Benijts, Tom; Günther, Wolfgang; Lambert, Willy; De Leenheer, André

    2002-07-01

    Sonic spray (SS) ionization is a relatively novel atmospheric pressure ionization technique for LC/MS, based on the principle of "spray ionization", which only recently became commercially available. In this paper, we evaluate the performance of this ion source as an interface for LC/MS in comparison with the more traditional and better studied pneumatically assisted electrospray or ion spray (IS). The effect of organic modifiers, volatile acids, and buffer systems in the LC eluent on the ionization efficiency of both interfaces is described and some possible explanations for the observed phenomena are highlighted. We could conclude that the presence of organic solvents gradually increased the ionization efficiency for IS and SS, while volatile acids or buffers gave a significant signal suppression. Furthermore, we present the application of the sonic spray interface to a fast LC/MS analysis, for the simultaneous determination of the seven prime opium alkaloids in heroin impurity profiling. Chromatographic separation is performed in 5 min on a monolithic silica column (Chromolith Performance) with a gradient elution system and an optimized flow of 5 mL/min. By means of a postcolumn split of approximately 1/20, a coupling between the fast LC system and the mass spectrometer is made. The method is validated and successfully applied to the analysis of real-time seized heroin street samples.

  19. Metabolic profile of Japanese Black breeding cattle herds: usefulness in selection for nutrient supplementation to enhance reproductive performance and regional differences.

    Science.gov (United States)

    Watanabe, Urara; Takagi, Mitsuhiro; Yamato, Osamu; Otoi, Takeshige; Tshering, Chenga; Okamoto, Koji

    2013-05-01

    The study aims were (1) to confirm the effects of nutritional improvement in prepartal and postpartal periods, monitored using the serum metabolic profile test (MPT) and reproductive performance, and (2) to clarify regional characteristics of the MPT results within our jurisdiction by using our MPT database. Experiment 1: Among 42 breeding cattle herds in our jurisdiction mainly fed home-pasture roughage, 3 experimental herds showing subnormal blood urea nitrogen (BUN) levels were selected and compared with 1 representative excellent herd. Dietary remedial measures were implemented from feed analysis in each herd. BUN concentration in all 3 herds increased significantly, and open days postpartum in 2 of the herds were significantly reduced, compared with values before dietary supplementation. Experiment 2: Thirty-seven herds within our jurisdiction were grouped into 3 categories (Area 1, 2 and 3) by location and soil condition of the herd pastureland. The MPT and reproductive performance in cows whose blood samples were collected at both prepartum (60-20 days before calving) and postpartum (30-90 days after calving) were compared among the 3 areas. Significant regional differences were found in prepartal albumin, total cholesterol, BUN, and glucose and postpartal BUN, glucose and open days (P<0.05). Overall, the MPT (especially BUN) might be useful for determining the metabolic nutritional status of breeding cattle herds, particularly those fed home-pasture roughage. Additionally, poor/unsatisfactory reproductive performance of beef breeding cattle herds probably reflects inadequate nutritional content of the diet, possibly arising from regional pastureland differences.

  20. Performance and metabolic profile of dairy cows during a lactational and deliberately induced negative energy balance with subsequent realimentation.

    Science.gov (United States)

    Gross, J; van Dorland, H A; Bruckmaier, R M; Schwarz, F J

    2011-04-01

    Homeorhetic and homeostatic controls in dairy cows are essential for adapting to alterations in physiological and environmental conditions. To study the different mechanisms during adaptation processes, effects of a deliberately induced negative energy balance (NEB) by feed restriction near 100 d in milk (DIM) on performance and metabolic measures were compared with lactation energy deficiency after parturition. Fifty multiparous cows were studied in 3 periods (1=early lactation up to 12 wk postpartum; 2=feed restriction for 3 wk beginning at 98±7 DIM with a feed-restricted and control group; and 3=a subsequent realimentation period for the feed-restricted group for 8 wk). In period 1, despite NEB in early lactation [-42 MJ of net energy for lactation (NE(L))/d, wk 1 to 3] up to wk 9, milk yield increased from 27.5±0.7 kg to a maximum of 39.5±0.8 kg (wk 6). For period 2, the NEB was induced by individual limitation of feed quantity and reduction of dietary energy density. Feed-restricted cows experienced a greater NEB (-63 MJ of NEL/d) than did cows in early lactation. Feed-restricted cows in period 2 showed only a small decline in milk yield of -3.1±1.1 kg and milk protein content of -0.2±0.1% compared with control cows (30.5±1.1 kg and 3.8±0.1%, respectively). In feed-restricted cows (period 2), plasma glucose was lower (-0.2±0.0 mmol/L) and nonesterified fatty acids higher (+0.1±0.1 mmol/L) compared with control cows. Compared with the NEB in period 1, the decreases in body weight due to the deliberately induced NEB (period 2) were greater (56±4 vs. 23±3 kg), but decreases in body condition score (0.16±0.03 vs. 0.34±0.04) and muscle diameter (2.0±0.4 vs. 3.5±0.4 mm) were lesser. The changes in metabolic measures in period 2 were marginal compared with the adjustments directly after parturition in period 1. Despite the greater induced energy deficiency at 100 DIM than the early lactation NEB, the metabolic load experienced by the dairy cows was not

  1. Periodic usage of low-protein methionine-fortified diets in broiler chickens under high ambient temperature conditions: effects on performance, slaughter traits, leukocyte profiles and antibody response.

    Science.gov (United States)

    Ghasemi, Hossein Ali; Ghasemi, Rohollah; Torki, Mehran

    2014-09-01

    This study was performed to evaluate the effects of adding methionine supplements to low-protein diets and subsequent re-feeding with a normal diet on the productive performance, slaughter parameters, leukocyte profiles and antibody response in broiler chickens reared under heat stress conditions.During the whole experimental period (6-49 days), the birds were raised in battery cages located in high ambient temperature in an open-sided housing system. A total of 360 6-day-old male chickens were divided into six treatments in six replicates with ten chicks each. Six isoenergetic diets, with similar total sulfur amino acids levels, were formulated to provide 100 and 100 (control), 85 and 100 (85S), 70 and 100 (70S), 85 and 85 (85SG), 70 and 85 (70S85G), and 70 and 70% (70SG) of National Research Council recommended levels for crude protein during the starter (6-21 day) and grower (22-42 day) periods, respectively. Subsequently, all groups received a diet containing the same nutrients during the finisher period (43-49 day). The results showed that, under heat stress conditions, average daily gain and feed conversion ratio and performance index from day 6 to 49, breast and thigh yields and antibody titer against Newcastle disease in the birds fed diets 85S, 70S and 85SG were similar to those of birds fed control diet, whereas feeding diets 70S85G and 70SG significantly decreased the values of above-mentioned parameters. Additionally, diets 85S, 70S and 85SG significantly decreased mortality rate and heterophil:lymphocyte ratio compared with the control diet. In conclusion, the results indicate that supplementation of methionine to diets 85S, 70S and 85SG, and then re-feeding with a conventional diet is an effective tool to maintain productive performance and to improve health indices and heat resistance in broilers under high ambient temperature conditions.

  2. Periodic usage of low-protein methionine-fortified diets in broiler chickens under high ambient temperature conditions: effects on performance, slaughter traits, leukocyte profiles and antibody response

    Science.gov (United States)

    Ghasemi, Hossein Ali; Ghasemi, Rohollah; Torki, Mehran

    2014-09-01

    This study was performed to evaluate the effects of adding methionine supplements to low-protein diets and subsequent re-feeding with a normal diet on the productive performance, slaughter parameters, leukocyte profiles and antibody response in broiler chickens reared under heat stress conditions. During the whole experimental period (6-49 days), the birds were raised in battery cages located in high ambient temperature in an open-sided housing system. A total of 360 6-day-old male chickens were divided into six treatments in six replicates with ten chicks each. Six isoenergetic diets, with similar total sulfur amino acids levels, were formulated to provide 100 and 100 (control), 85 and 100 (85S), 70 and 100 (70S), 85 and 85 (85SG), 70 and 85 (70S85G), and 70 and 70 % (70SG) of National Research Council recommended levels for crude protein during the starter (6-21 day) and grower (22-42 day) periods, respectively. Subsequently, all groups received a diet containing the same nutrients during the finisher period (43-49 day). The results showed that, under heat stress conditions, average daily gain and feed conversion ratio and performance index from day 6 to 49, breast and thigh yields and antibody titer against Newcastle disease in the birds fed diets 85S, 70S and 85SG were similar to those of birds fed control diet, whereas feeding diets 70S85G and 70SG significantly decreased the values of above-mentioned parameters. Additionally, diets 85S, 70S and 85SG significantly decreased mortality rate and heterophil:lymphocyte ratio compared with the control diet. In conclusion, the results indicate that supplementation of methionine to diets 85S, 70S and 85SG, and then re-feeding with a conventional diet is an effective tool to maintain productive performance and to improve health indices and heat resistance in broilers under high ambient temperature conditions.

  3. Effects of different space allowances on growth performance, blood profile and pork quality in a grow-to-finish production system.

    Science.gov (United States)

    Jang, J C; Jin, X H; Hong, J S; Kim, Y Y

    2017-06-26

    This experiment was conducted to evaluate the optimal space allowance on growth performance, blood profile and pork quality of growing-finishing pigs. A total of ninety crossbred pigs ([Yorkshire x Landrace] x Duroc, 30.25 ± 1.13 kg) were allocated into three treatments (0.96: four pigs / pen, 0.96 m2/pig; 0.80: five pigs / pen, 0.80 m2/pig; 0.69: six pigs / pen, 0.69 m2/pig) in a randomized complete block (RCB) design. Pigs were housed in balanced sex and had free access to feed in all phases for 14 weeks (growing phase I, growing phase II, finishing phase I and finishing phase II). There was no statistical difference in growing phase, but a linear decrease was observed on average daily gain (ADG, pfinishing phase. On the other hand, a quadratic effect was observed on gain to feed ratio in early finishing phase (pfinish production system is more than 0.80 m2/pig for maximizing growth performance and production efficiency.

  4. Effect of particle pinch on the fusion performance and profile features of an international thermonuclear experimental reactor-like fusion reactor

    Science.gov (United States)

    Wang, Shijia; Wang, Shaojie

    2015-04-01

    The evolution of the plasma temperature and density in an international thermonuclear experimental reactor (ITER)-like fusion device has been studied by numerically solving the energy transport equation coupled with the particle transport equation. The effect of particle pinch, which depends on the magnetic curvature and the safety factor, has been taken into account. The plasma is primarily heated by the alpha particles which are produced by the deuterium-tritium fusion reactions. A semi-empirical method, which adopts the ITERH-98P(y,2) scaling law, has been used to evaluate the transport coefficients. The fusion performances (the fusion energy gain factor, Q) similar to the ITER inductive scenario and non-inductive scenario (with reversed magnetic shear) are obtained. It is shown that the particle pinch has significant effects on the fusion performance and profiles of a fusion reactor. When the volume-averaged density is fixed, particle pinch can lower the pedestal density by ˜30 % , with the Q value and the central pressure almost unchanged. When the particle source or the pedestal density is fixed, the particle pinch can significantly enhance the Q value by 60 % , with the central pressure also significantly raised.

  5. Replacement of grass and maize silages with lucerne silage: effects on performance, milk fatty acid profile and digestibility in Holstein-Friesian dairy cows.

    Science.gov (United States)

    Sinclair, L A; Edwards, R; Errington, K A; Holdcroft, A M; Wright, M

    2015-12-01

    In total, 20 multiparous Holstein-Friesian dairy cows received one of four diets in each of four periods of 28-day duration in a Latin square design to test the hypothesis that the inclusion of lucerne in the ration of high-yielding dairy cows would improve animal performance and milk fatty acid (FA) composition. All dietary treatments contained 0.55 : 0.45 forage to concentrates (dry matter (DM) basis), and within the forage component the proportion of lucerne (Medicago sativa), grass (Lolium perenne) and maize silage (Zea mays) was varied (DM basis): control (C)=0.4 : 0.6 grass : maize silage; L20=0.2 : 0.2 : 0.6 lucerne : grass : maize silage; L40=0.4 : 0.6 lucerne : maize silage; and L60=0.6 : 0.4 lucerne : maize silage. Diets were formulated to contain a similar CP and metabolisable protein content, with the reduction of soya bean meal and feed grade urea with increasing content of lucerne. Intake averaged 24.3 kg DM/day and was lowest in cows when fed L60 (P0.05) by dietary treatment. Digestibility of DM, organic matter, CP and fibre decreased (Psilage can be replaced with first cut lucerne silage without any detrimental effect on performance and an improvement in the milk FA profile, although intake and digestibility was lowest and plasma urea concentrations highest in cows when fed the highest level of inclusion of lucerne.

  6. Development of a high-throughput ultra performance liquid chromatography-mass spectrometry assay to profile 18 eicosanoids as exploratory biomarkers for atherosclerotic diseases.

    Science.gov (United States)

    Rago, Brian; Fu, Cexiong

    2013-10-01

    Abundant evidence suggests a prominent role for eicosanoids and metabolites in the pathogenesis and prognosis of inflammatory diseases. A sensitive and high-throughput SPE UPLC-MS/MS method was developed to quantitatively interrogate the levels of 18 eicosanoids in human and monkey plasma samples. A limit of quantitation of 0.25ng/mL was achieved for all 18 investigated compounds with linear ranges spanning four orders of magnitude. Bioanalytical performance of this assay was fully characterized including SPE extraction efficiency, matrix effect, autosampler stability, benchtop stability and freeze-thaw cycle variability. Endogenous levels of the eicosanoids and analogs within a set of monkey plasma samples challenged with lipopolysaccharide and human plasma samples were quantified by this ultra performance liquid chromatography-mass spectrometry (UPLC-MS/MS) assay. Quantitative eicosanoid profiles of the human samples were further analyzed by a non-supervised cluster analysis, which revealed a set of potential positive and negative lipid biomarkers to distinguish the following three groups: healthy individuals, hypertensive patients and severe atherosclerosis patients. The components of the negative biomarker cluster (8-HETE, LTB4, 9-HODE and 13-HODE) are putative ligands of peroxisome proliferator-activated receptors (PPARs), a family of master genes controlling the resolution of inflammatory signaling.

  7. Effects of dietary resistant starch content on metabolic status, milk composition, and microbial profiling in lactating sows and on offspring performance.

    Science.gov (United States)

    Yan, H; Lu, H; Almeida, V V; Ward, M G; Adeola, O; Nakatsu, C H; Ajuwon, K M

    2017-02-01

    In the present study, the effects of dietary resistant starch (RS) content on serum metabolite and hormone concentrations, milk composition, and faecal microbial profiling in lactating sows, as well as on offspring performance was investigated. Sixteen sows were randomly allotted at breeding to two treatments containing low- and high-RS contents from normal and high-amylose corn varieties, respectively, and each treatment had eight replicates (sows). Individual piglet body weight (BW) and litter size were recorded at birth and weaning. Milk samples were obtained on day 10 after farrowing for composition analysis. On day 2 before weaning, blood and faecal samples were collected to determine serum metabolite and hormone concentrations and faecal microbial populations, respectively. Litter size at birth and weaning were not influenced (p > 0.05) by the sow dietary treatments. Although feeding the RS-rich diet to sows reduced (p = 0.004) offspring birth BW, there was no difference in piglet BW at weaning (p > 0.05). High-RS diet increased (p sows. Feeding the RS-rich diet to sows increased (p sows, as well as a greater nutrient density in maternal milk, without affecting offspring performance at weaning. Journal of Animal Physiology and Animal Nutrition © 2016 Blackwell Verlag GmbH.

  8. Milk fatty acid profile and dairy sheep performance in response to diet supplementation with sunflower oil plus incremental levels of marine algae.

    Science.gov (United States)

    Toral, P G; Hervás, G; Gómez-Cortés, P; Frutos, P; Juárez, M; de la Fuente, M A

    2010-04-01

    In an attempt to develop strategies for enhancing the nutritional value of sheep milk fat, dairy ewe diet was supplemented with 3 incremental levels of marine algae (MA), in combination with sunflower oil, to evaluate the effects of these marine lipids on milk fatty acid (FA) profile and animal performance. Fifty Assaf ewes in mid lactation were distributed in 10 lots of 5 animals each and allocated to 5 treatments (2 lots per treatment): no lipid supplementation (control) or supplementation with 25 g of sunflower oil/kg of DM plus 0 (SO), 8 (SOMA(1)), 16 (SOMA(2)), or 24 (SOMA(3)) g of MA (56.7% ether extract)/kg of DM. Milk production and composition, including FA profile, were analyzed on d 0, 3, 7, 14, 21, and 28 of treatment. Neither intake nor milk yield were significantly affected by lipid addition, but all MA supplements decreased milk fat content from d 14 onward, reaching a 30% reduction after 28 d on SOMA(3). This milk fat depression might be related not only to the joint action of some putative fat synthesis inhibitors, such as trans-9,cis-11 C18:2 and probably trans-10 C18:1, but also to the limited ability of the mammary gland to maintain a desirable milk fat fluidity, that would have been caused by the noticeable increase in trans-C18:1 together with the lowered availability of stearic acid for oleic acid synthesis through Delta(9)-desaturase. Furthermore, all lipid supplements, and mainly MA, reduced the secretion of de novo FA (C6:0-C14:0) without increasing the yield of preformed FA (>C16). Supplementation with sunflower oil plus MA resulted in larger increases in cis-9,trans-11 C18:2 than those observed with sunflower oil alone, achieving a mean content as high as 3.22% of total FA and representing a more than 7-fold increase compared with the control. Vaccenic acid (trans-11 C18:1) was also significantly enhanced (on average +794% in SOMA treatments), as was C22:6 n-3 (DHA) content, although the transfer efficiency of the latter, from the diets

  9. Quantitative Metabolite Profiling of an Amino Group Containing Pharmaceutical in Human Plasma via Precolumn Derivatization and High-Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry.

    Science.gov (United States)

    Li, Sanwang; Klencsár, Balázs; Balcaen, Lieve; Cuyckens, Filip; Lynen, Frederic; Vanhaecke, Frank

    2017-02-07

    Quantitative determination of the candidate drug molecule and its metabolites in biofluids and tissues is an inevitable step in the development of new pharmaceuticals. Because of the time-consuming and expensive nature of the current standard technique for quantitative metabolite profiling, i.e., radiolabeling followed by high-performance liquid chromatography (HPLC) with radiodetection, the development of alternative methodologies is of great interest. In this work, a simple, fast, sensitive, and accurate method for the quantitative metabolite profiling of an amino group containing drug (levothyroxine) and its metabolites in human plasma, based on precolumn derivatization followed by HPLC-inductively coupled plasma mass spectrometry (ICPMS), was developed and validated. To introduce a suitable "heteroelement" (defined here as an element that is detectable with ICPMS), an inexpensive and commercially available reagent, tetrabromophthalic anhydride (TBPA) was used for the derivatization of free NH2-groups. The presence of a known number of I atoms in both the drug molecule and its metabolites enabled a cross-validation of the newly developed derivatization procedure and quantification based on monitoring of the introduced Br. The formation of the derivatives was quantitative, providing a 4:1 stoichiometric Br/NH2 ratio. The derivatives were separated via reversed-phase HPLC with gradient elution. Bromine was determined via ICPMS at a mass-to-charge ratio of 79 using H2 as a reaction gas to ensure interference-free detection, and iodine was determined at a mass-to-charge ratio of 127 for cross-validation purposes. The method developed shows a fit-for-purpose accuracy (recovery between 85% and 115%) and precision (repeatability <15% RSD). The limit of quantification (LoQ) for Br was approximately 100 μg/L.

  10. Effects of High Performance Inulin Supplementation on Glycemic Status and Lipid Profile in Women with Type 2 Diabetes: A Randomized, Placebo-Controlled Clinical Trial

    Directory of Open Access Journals (Sweden)

    Parvin Dehghan

    2013-06-01

    Full Text Available Background: Type 2 diabetes mellitus, as a noncommunicable disease, is the main public health challenge in the 21st century. The prevalence of di¬abetes mellitus adjusted for the world population in Iran was 8% until the year 2010. Lipid levels are considered as important parameters to be eva¬luated, as high serum lipid levels are often reported as a complication in patients with diabetes mellitus. It is claimed that functional foods may im¬prove complications of diabetes mellitus, so this study was designed to evaluate the effects of high performance inulin on glycemic status and lipid profile of women with type 2 diabetes.Methods: The study was a randomized controlled clinical trial. Forty-nine type 2 diabetic females (fiber intake <30g/d, 25profile indices were measured pre and post intervention. Data were analyzed using SPSS software (verision11.5. Paired, unpaired t-test and ANCOVA were used to compare quantitative variables.Results: Supplementation with inulin caused a significant reduction in FBS (8.50%, HbA1c (10.40%, total cholesterol (12.90%, triglyceride (23.60 %, LDL-c (35.30 %, LDL-c/HDL-c ratio (16.25% and TC/HDL-c ratio (25.20% and increased HDL-c (19.90%. The changes for the control group parameters were not significant at the end of study. Conclusion: Inulin may help to control diabetes and its complications via improving glycemic and lipid parameters.

  11. Effect of yellow lupine (L. luteus) on the egg yolk fatty acid profile, the physicochemical and sensory properties of eggs, and laying hen performance.

    Science.gov (United States)

    Krawczyk, Magdalena; Przywitowski, Marcin; Mikulski, Dariusz

    2015-06-01

    The aim of this study was to evaluate the effects of different dietary inclusion of raw yellow lupine seed meal (YLM) on laying hen performance, the fatty acid (FA) profile, physicochemical, and sensory properties of eggs. A total of 224 Lohmann Brown laying hens at 32 wk age were fed isonitrogenous and isocaloric diets for 16 wk. The control diet contained soybean meal (SBM), and in study diets SBM was replaced with YLM at 100, 200, or 300 g/kg. In comparison with soybean, lupine seeds had a higher content of nonstarch polysaccharides (NSP) and raffinose family oligosaccharides (RFO) (29.5 vs. 14.0 and 8.56 vs. 5.91% DM). The dietary 300 g/kg lupine seeds increased the content of NSP and RFO in the ration, from 9.34 to 13.39 and 1.36 to 2.54%, respectively. The YLM inclusion level had no adverse effect on laying performance, including feed intake, FCR, egg production, and egg weight. The final BW of hens fed lupine-based diets were significantly higher compared with the control (P=0.039). Throughout the study, dietary treatments had no effect on eggshell and albumen quality. An increase in the inclusion rate of YLM was followed by a linear increase (Plupine seeds in experimental diets caused a linear increase in n-6 polyunsaturated FA (PUFA) content and the n-6/n-3 ratio (all P<0.001), but it had no influence on the atherogenic and the thrombogenic indices of egg yolk lipids. The results of this study indicate that YLM can be included at 300 g/kg in layer diets as a partial substitute for soybean meal without compromising laying performance, the physicochemical, and sensory properties of eggs. © 2015 Poultry Science Association Inc.

  12. Effect of dietary supplementation of grape seed extract on the growth performance, lipid profile, antioxidant status and immune response of broiler chickens.

    Science.gov (United States)

    Farahat, M H; Abdallah, F M; Ali, H A; Hernandez-Santana, A

    2017-05-01

    Grape seed extracts (GSE) contain several beneficial bioactive constituents; therefore, can be utilized as a potential feed additive in broiler chickens. An experiment was conducted to investigate the effect of supplementation of broiler chicken diets with GSE as a natural antioxidant at levels of 125, 250, 500, 1000 and 2000 ppm on the growth performance, serum lipid profile, liver glutathione-reduced, thigh muscle malondialdehyde and humoral immune response against Newcastle disease virus vaccines. This experiment was performed during the life-span of chickens from 0 to 42 days of age. The results of broilers fed on diet supplemented by GSE were compared with those fed on the basal diet (control) or the basal diet supplemented by butylated hydroxytoluene as a synthetic antioxidant (BHT, 125 ppm). No significant differences were observed in the growth performance, percent livability, total lipid, high and very low-density lipoprotein cholesterols when the use of GSE or BHT were compared with the control. Total cholesterol and low-density lipoprotein cholesterol were significantly decreased after intake of GSE compared with BHT in the feed diet. The glutathione-reduced level in liver tissues was significantly increased by inclusion of GSE, but not by BHT. Inclusion of GSE or BHT decreased significantly the malondialdehyde level found in meat tissue. The antibody titer against Newcastle disease virus vaccines was significantly elevated in 28 and 35-day-old broiler chickens fed with a diet supplemented with GSE or BHT, the former providing a higher response. It can be concluded that GSE can be used as an effective natural antioxidant and immunostimulant agent in broiler chicken diets, and that 125 to 250 ppm can be considered as the optimum dosage.

  13. Lipid Profile

    Science.gov (United States)

    ... AACC products and services. Advertising & Sponsorship: Policy | Opportunities Lipid Profile Share this page: Was this page helpful? Also ... as: Lipid Panel; Coronary Risk Panel Formal name: Lipid Profile Related tests: Cholesterol ; HDL Cholesterol ; LDL Cholesterol ; Triglycerides ; ...

  14. Metabolic Profiling of the Uncaria Hook Alkaloid Geissoschizine Methyl Ether in Rat and Human Liver Microsomes Using High-Performance Liquid Chromatography with Tandem Mass Spectrometry

    Directory of Open Access Journals (Sweden)

    Hirotaka Kushida

    2015-01-01

    Full Text Available Geissoschizine methyl ether (GM is an indole alkaloid found in Uncaria hook, which is a galenical constituent of yokukansan, a traditional Japanese medicine. GM has been identified as the active component responsible for anti-aggressive effects. In this study, the metabolic profiling of GM in rat and human liver microsomes was investigated. Thirteen metabolites of GM were elucidated and identified using a high-performance liquid chromatography with tandem mass spectrometry method, and their molecular structures were proposed on the basis of the characteristics of their precursor ions, product ions, and chromatographic retention times. There were no differences in the metabolites between the rat and human liver microsomes. Among the 13 identified metabolites, there were two demethylation metabolites, one dehydrogenation metabolite, three methylation metabolites, three oxidation metabolites, two water-adduct metabolites, one di-demethylation metabolite, and one water-adduct metabolite followed by oxidation. The metabolic pathways of GM were proposed on the basis of this study. This study will be helpful in understanding the metabolic routes of GM and related Uncaria hook alkaloids, and provide useful information on the pharmacokinetics and pharmacodynamics. This is the first report that describes the separation and identification of GM metabolites in rat and human liver microsomes.

  15. Combined multivariate data analysis of high-performance thin-layer chromatography fingerprints and direct analysis in real time mass spectra for profiling of natural products like propolis.

    Science.gov (United States)

    Morlock, Gertrud E; Ristivojevic, Petar; Chernetsova, Elena S

    2014-02-07

    Sophisticated statistical tools are required to extract the full analytical power from high-performance thin-layer chromatography (HPTLC). Especially, the combination of HPTLC fingerprints (image) with chemometrics is rarely used so far. Also, the newly developed, instantaneous direct analysis in real time mass spectrometry (DART-MS) method is perspective for sample characterization and differentiation by multivariate data analysis. This is a first novel study on the differentiation of natural products using a combination of fast fingerprint techniques, like HPTLC and DART-MS, for multivariate data analysis. The results obtained by the chemometric evaluation of HPTLC and DART-MS data provided complementary information. The complexity, expense, and analysis time were significantly reduced due to the use of statistical tools for evaluation of fingerprints. The approach allowed categorizing 91 propolis samples from Germany and other locations based on their phenolic compound profile. A high level of confidence was obtained when combining orthogonal approaches (HPTLC and DART-MS) for ultrafast sample characterization. HPTLC with selective post-chromatographic derivatization provided information on polarity, functional groups and spectral properties of marker compounds, while information on possible elemental formulae of principal components (phenolic markers) was obtained by DART-MS. Copyright © 2013 Elsevier B.V. All rights reserved.

  16. Effect of supplementing different oils: linseed, sunflower and soybean, on animal performance, carcass characteristics, meat quality and fatty acid profile of veal from "Rubia Gallega" calves.

    Science.gov (United States)

    González, Laura; Moreno, Teresa; Bispo, Esperanza; Dugan, Michael E R; Franco, Daniel

    2014-02-01

    The fatty acid (FA) composition of longisimus dorsi (LD) and subcutaneous fat (SCF) from Rubia Gallega (RG) calves was compared for three dietary oil sources (linseed, LO; sunflower, SFO or soybean, SYO). Oils were added (4.5%) to a commercial concentrate and no differences on animal performance, carcass characteristics or meat quality among diets were noted. Total n-3 polyunsaturated FA (PUFA) increased in LD and SCF when feeding LO diet (P<0.001). The trans(t) FA profiles were dominated by t11-18:1, except when feeding SFO diet, where ∑t6- to t10-18:1 exceeded t11-18:1 leading the highest (∑t6-to t10-18:1)/t11-18:11 ratio in LD (P<0.05). The overall changes in n-3 PUFA and t18:1 when feeding LO and SYO could be viewed as positive for human health, but quantitatively it was apparent that most dietary PUFA were completely biohydrogenated. Inhibiting PUFA biohydrogenation will be an important next step to improve the FA composition of RG cattle.

  17. Profiling and multivariate statistical analysis of Panax ginseng based on ultra-high-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry.

    Science.gov (United States)

    Wu, Wei; Sun, Le; Zhang, Zhe; Guo, Yingying; Liu, Shuying

    2015-03-25

    An ultra-high-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) method was developed for the detection and structural analysis of ginsenosides in white ginseng and related processed products (red ginseng). Original neutral, malonyl, and chemically transformed ginsenosides were identified in white and red ginseng samples. The aglycone types of ginsenosides were determined by MS/MS as PPD (m/z 459), PPT (m/z 475), C-24, -25 hydrated-PPD or PPT (m/z 477 or m/z 493), and Δ20(21)-or Δ20(22)-dehydrated-PPD or PPT (m/z 441 or m/z 457). Following the structural determination, the UHPLC-Q-TOF-MS-based chemical profiling coupled with multivariate statistical analysis method was applied for global analysis of white and processed ginseng samples. The chemical markers present between the processed products red ginseng and white ginseng could be assigned. Process-mediated chemical changes were recognized as the hydrolysis of ginsenosides with large molecular weight, chemical transformations of ginsenosides, changes in malonyl-ginsenosides, and generation of 20-(R)-ginsenoside enantiomers. The relative contents of compounds classified as PPD, PPT, malonyl, and transformed ginsenosides were calculated based on peak areas in ginseng before and after processing. This study provides possibility to monitor multiple components for the quality control and global evaluation of ginseng products during processing. Copyright © 2014 Elsevier B.V. All rights reserved.

  18. Metabolic profile of salidroside in rats using high-performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry.

    Science.gov (United States)

    Han, Fei; Li, Yan-ting; Mao, Xin-juan; Zhang, Xiao-shu; Guan, Jiao; Song, Ai-hua; Yin, Ran

    2016-03-01

    A high-performance liquid chromatography coupled to Fourier transform ion cyclotron resonance mass spectrometry (HPLC-FT-ICR MS) method was developed to study the in vivo metabolism of salidroside for the first time. Plasma, urine, bile, and feces samples were collected from male rats after a single intragastric gavage of salidroside at a dose of 50 mg/kg. Besides the parent drug, a total of seven metabolites (three phase I and four phase II metabolites) were detected and tentatively identified by comparing their mass spectrometry profiles with those of salidroside. Results indicated that metabolic pathways of salidroside in male rats included hydroxylation, dehydrogenation, glucuronidation, and sulfate conjugation. Among them, glucuronidation and sulfate conjugation were the major metabolic reactions. And most important, the detection of the sulfation metabolite of p-tyrosol provides a clue for whether the deglycosylation of salidroside occurs in vivo after intragastric gavage. In summary, results obtained in this study may contribute to the better understanding of the safety and mechanism of action of salidroside.

  19. Data Profiling

    OpenAIRE

    Hladíková, Radka

    2010-01-01

    Title: Data Profiling Author: Radka Hladíková Department: Department of Software Engineering Supervisor: Ing. Vladimír Kyjonka Supervisor's e-mail address: Abstract: This thesis puts mind on problems with data quality and data profiling. This Work analyses and summarizes problems of data quality, data defects, process of data quality, data quality assessment and data profiling. The main topic is data profiling as a process of researching data available in existing...

  20. Effect of dietary energy levels and phase feeding by protein levels on growth performance, blood profiles and carcass characteristics in growing-finishing pigs.

    Science.gov (United States)

    Hong, J S; Lee, G I; Jin, X H; Kim, Y Y

    2016-01-01

    Providing of insufficient nutrients limits the potential growth of pig, while feeding of excessive nutrients increases the economic loss and causes environment pollution. For these reasons, phase feeding had been introduced in swine farm for improving animal production. This experiment was conducted to evaluate the effects of dietary energy levels and phase feeding by protein levels on growth performance, blood profiles and carcass characteristics in growing-finishing pigs. A total of 128 growing pigs ([Yorkshire × Landrace] × Duroc), averaging 26.62 ± 3.07 kg body weight, were assigned in a 2 × 4 factorial arrangement with 4 pigs per pen. The first factor was two dietary energy level (3,265 kcal of ME/kg or 3,365 kcal of ME/kg), and the second factor was four different levels of dietary protein by phase feeding (1growing(G)-2finishing(F) phases, 2G-2F phases, 2G-3F phases and 2G-3F phases with low CP requirement). In feeding trial, there was no significant difference in growth performance. The BUN concentration was decreased as dietary protein level decreased in 6 week and blood creatinine was increased in 13 week when pigs were fed diets with different dietary energy level. The digestibility of crude fat was improved as dietary energy levels increased and excretion of urinary nitrogen was reduced when low protein diet was provided. Chemical compositions of longissimus muscle were not affected by dietary treatments. In backfat thickness (P2) at 13 week, pigs fed high energy diet had thicker backfat thickness (P = 0.06) and pigs fed low protein diet showed the trend of backfat thinness reduction (P = 0.09). In addition, water holding capacity was decreased (P = 0.01) and cooking loss was increased (P = 0.07) as dietary protein level reduced. When pigs were fed high energy diet with low subdivision of phase feeding, days to 120 kg market weight was reached earlier compared to other treatments. Feeding the low energy diet

  1. Chemical profiling and quantification of Gua-Lou-Gui-Zhi decoction by high performance liquid chromatography/quadrupole-time-of-flight mass spectrometry and ultra-performance liquid chromatography/triple quadrupole mass spectrometry.

    Science.gov (United States)

    Xu, Wen; Huang, Mingqing; Li, Huang; Chen, Xianwen; Zhang, Yuqin; Liu, Jie; Xu, Wei; Chu, Kedan; Chen, Lidian

    2015-04-01

    Gua-Lou-Gui-Zhi decoction (GLGZD) is a classical formula of traditional Chinese medicine, which has been commonly used to treat dysfunction after stroke, epilepsy and spinal cord injury. In this study, a systematic method was established for chemical profiling and quantification analysis of the major constituents in GLGZD. For qualitative analysis, a method of high performance liquid chromatography/quadrupole time-of-flight mass spectrometry (Q-TOF MS) was developed. 106 compounds, including monoterpene glycosides, galloyl glucoses, phenolic acids, flavonoids, gingerols and triterpene saponins were identified or tentatively presumed by comparison with reference standards or literature data. According to the qualitative results, a new quantitative analysis method of ultra-performance liquid chromatography/triple quadrupole mass spectrometry (QqQ-MS) was established. 24 representative compounds were simultaneously detected in 10 batches of GLGZD samples in 7.5 min. The calibration curves for all analytes showed good linearity (r>0.9959) within the test ranges. The LODs and the LOQs were less than 30.6 and 70.9 ng/mL, respectively. The RSDs of intra- and inter-day precision, repeatability and stability were below 3.64%, 4.85%, 4.84% and 3.87%, respectively. The overall recoveries ranged from 94.94% to 103.66%, with the RSDs within 5.12%. This study established a high sensitive and efficient method for the integrating quality control, including identification and quantification of Chinese medicinal preparation.

  2. Effect of alcohol fermented feed on lactating performance, blood metabolites, milk Fatty Acid profile and cholesterol content in holstein lactating cows.

    Science.gov (United States)

    Li, X Z; Park, B K; Yan, C G; Choi, J G; Ahn, J S; Shin, J S

    2012-11-01

    A feeding experiment with 40 lactating Holstein cows and 4 dietary treatments was conducted to investigate supplementation with different levels of alcohol fermented feed to the TMR on lactating performance, blood metabolites, milk fatty acid profile and cholesterol concentration of blood and milk. Forty Holstein lactating cows (106±24 d post-partum; mean±SD) were distributed into four groups and randomly assigned to one of four treatments with each containing 10 cows per treatment. The treatment supplemented with TMR (DM basis) as the control (CON), and CON mixed with alcohol-fermented feeds (AFF) at a level of 5%, 10% and 15% of the TMR as T1, T2 and T3, respectively. Dry matter intake and milk yield were not affected by supplementation of AFF. An increased 4% FCM in the milk occurred in cows fed T3 diet compared with CON, while T1 and T2 diets decreased 4% FCM in a dose dependent manner. Supplementation of AFF increased the concentration of albumin, total protein (TP), ammonia, and high density lipoprotein-cholesterol in serum compared with CON. In contrast, supplementation with AFF clearly decreased concentration of blood urea nitrogen (BUN) and total cholesterol (TC) compare with CON. AFF supplementation increased the proportion of C18:1n9 and C18:2n6 compared to CON. A decrease in the concentration of saturated fatty acid (SFA) for T1, T2 and T3 resulted in an increased unsaturated fatty acid (USFA) to SFA ratio compared to CON. Concentration of cholesterol in milk fat was reduced in proportion to the supplemental level of AFF. Feeding a diet supplemented with a moderate level AFF to lactating cows could be a way to alter the feed efficiency and fatty acid profile of milk by increasing potentially human consumer healthy fatty acid without detrimental effects on feed intake and milk production. A substantially decreased cholesterol proportion in milk induced by supplementation AFF suggests that alcohol fermented feed may improve milk cholesterol levels

  3. Metabolic profile of Fructus Gardeniae in human plasma and urine using ultra high-performance liquid chromatography coupled with high-resolution LTQ-orbitrap mass spectrometry.

    Science.gov (United States)

    Wang, Gao-Wa; Bao, Burenbatu; Han, Zhi-Qiang; Han, Qing-Yu; Yang, Xiu-Lan

    2016-10-01

    1. In China, Fructus Gardeniae was used as a traditional Chinese medicine (TCM) with a wide array of biological activities. The bioactive components identified in Fructus Gardeniae mainly included iridoids, flavonids, pigments, and so on. Among them, iridoids were regarded as important compounds in Fructus Gardeniae. Though analyses of the constituents in biological samples after oral administration of Fructus Gardeniae effective fraction or its active compounds have been reported, few efforts have been made to investigate the metabolic profile of Fructus Gardeniae in humans. In this study, the constituents and metabolites of Fructus Gardeniae in human blood and urine after oral administration of Fructus Gardeniae were investigated using ultra high-performance liquid chromatography (UHPLC) coupled with high-resolution LTQ-Orbitrap mass spectrometery. 2. Totally, 14 constituents (two parent compounds and 12 metabolites) of Fructus Gardeniae were identified in human plasma and urine either by comparing the retention time and mass spectrometry data with that of reference compounds or by the accurate high-resolution MS/MS data of the chemicals. The compounds identified were mainly iridoid glycosides such as geniposide and the derivatives of genipin-O-glucuronide. Among them, 11 metabolites were detected in human plasma and urine while the other three metabolites including geniposidic acid (M1), demethylation derivative of genipin-O-glucuronide (M2), and dehydration product of mono-hydroxylated genipin-O-glucuronide (M9) were only discovered in human urine. Further, the possible metabolic pathways of Fructus Gardeniae in vivo were proposed and the peak area-time curve of the most abundant metabolite genipin-O-glucuronide (M13) in human plasma after oral administration of Fructus Gardeniae was depicted. The results suggested that a metabolic difference existed between rats and humans. 3. The results obtained in the present research would provide basic information to

  4. Effect of Alcohol Fermented Feed on Lactating Performance, Blood Metabolites, Milk Fatty Acid Profile and Cholesterol Content in Holstein Lactating Cows

    Directory of Open Access Journals (Sweden)

    X. Z. Li

    2012-11-01

    Full Text Available A feeding experiment with 40 lactating Holstein cows and 4 dietary treatments was conducted to investigate supplementation with different levels of alcohol fermented feed to the TMR on lactating performance, blood metabolites, milk fatty acid profile and cholesterol concentration of blood and milk. Forty Holstein lactating cows (106±24 d post-partum; mean±SD were distributed into four groups and randomly assigned to one of four treatments with each containing 10 cows per treatment. The treatment supplemented with TMR (DM basis as the control (CON, and CON mixed with alcohol-fermented feeds (AFF at a level of 5%, 10% and 15% of the TMR as T1, T2 and T3, respectively. Dry matter intake and milk yield were not affected by supplementation of AFF. An increased 4% FCM in the milk occurred in cows fed T3 diet compared with CON, while T1 and T2 diets decreased 4% FCM in a dose dependent manner. Supplementation of AFF increased the concentration of albumin, total protein (TP, ammonia, and high density lipoprotein-cholesterol in serum compared with CON. In contrast, supplementation with AFF clearly decreased concentration of blood urea nitrogen (BUN and total cholesterol (TC compare with CON. AFF supplementation increased the proportion of C18:1n9 and C18:2n6 compared to CON. A decrease in the concentration of saturated fatty acid (SFA for T1, T2 and T3 resulted in an increased unsaturated fatty acid (USFA to SFA ratio compared to CON. Concentration of cholesterol in milk fat was reduced in proportion to the supplemental level of AFF. Feeding a diet supplemented with a moderate level AFF to lactating cows could be a way to alter the feed efficiency and fatty acid profile of milk by increasing potentially human consumer healthy fatty acid without detrimental effects on feed intake and milk production. A substantially decreased cholesterol proportion in milk induced by supplementation AFF suggests that alcohol fermented feed may improve milk cholesterol

  5. Effect of Dietary Omega-3 to Omega-6 Ratio on Growth Performance, Immune Response, Carcass Traits and Meat Fatty Acids Profile of Broiler Chickens

    Directory of Open Access Journals (Sweden)

    El-Katcha MI

    2014-12-01

    Full Text Available This experiment was conducted to study the effect of dietary n-3 to n-6 ratio on performance, immune response, blood parameters and fatty acids profile of broiler chickens. A total number of 192 one day old broiler chicks were randomly alloctted into 6 groups. Chicks of groups 1, 2, 3, 4, 5 and 6 were fed balanced corn-soybean diets containing n-3 to n-6 ratios of 1:1, 1:3, 1:5, 1:7, 1:9 and 1:11, respectively. Different n-3 to n-6 ratioes had no significant effect on growth performance parameters. The best dressing percentage was recorded in group 3 while no significant difference was noticed in the weight of organs except for a significant increase in the weight of gizzard in group 4. There was a variable effect of the n-3 to n-6 ratio on parameters of innate immunity. The highest lymphocyte percentage was detected in group 5. Antibody titers against Newcastle disease (ND and Avian Influenza (AI increased in wider ratio groups. The lowest glucose level was detected in group 4. Though serum albumin and total protein were decreased in group 3, serum globulin increased in groups 2 and 3. The lowest cholesterol content of breast meat was detected in group 3 and the highest content was detected in group 6. The cholesterol content of the thigh recorded opposite results. Narrow dietary n-3 to n-6 groups tended to record higher n-3 PUFAs content especially DHA in breast meat. While wider n-3 to n-6 ratio groups tended to deposit more SFAS, MUFAs and n-6 PUFAs than the narrower ratio groups. The best n-3 to n-6 ratio of breast meat was recorded in group 2 receiving dietary n-3 to n-6 ratio of 1:3. From the results of this study, it could be concluded that the dietary n-3 to n-6 ratio had no significant effect on growth performance of broiler chickens. The best dressing percentage was detected in group with the ratio of 1:5. The ratio of 1:3 recorded the best health state parameters.

  6. Floating patella: combined quadriceps tendon, retinacula, and patellar tendon ruptures in a high-performance elite athlete.

    Science.gov (United States)

    Langer, Phillip R; Selesnick, F Harlan

    2010-09-01

    Simultaneous quadriceps and patellar tendon rupture is rare. To our knowledge, we present the first known case of simultaneous quadriceps tendon, patella tendon, and retinacula rupture in the ipsilateral knee of a high-performance elite athlete. This disabling injury in the active person results in an inability to actively obtain and maintain full knee extension. When the tendons do not heal properly, at the correct length and tension, knee range of motion and strength can become significantly altered, leading to early fatigue, patellofemoral pain, and possibly instability, preventing return to preinjury status. Immediate surgical repair is recommended for optimal return of knee function and power.

  7. Karolinske psychodynamic profile (KAPP)

    DEFF Research Database (Denmark)

    Mathiesen, Birgit Bork; Søgaard, Ulf

    2006-01-01

    psykologiske testmetoder, assesment, Karolinska psychodynamic profile (KAPP), psykodynamisk profil......psykologiske testmetoder, assesment, Karolinska psychodynamic profile (KAPP), psykodynamisk profil...

  8. [WISC-IV performances of young male subjects with AD(H)D, the benefits of applying cognitive profile analysis to diagnostics].

    Science.gov (United States)

    Walg, Marco; Bowi, Ulrike; El-Wahsch, Daniel

    2016-01-01

    Studies suggest that children and adolescents suffering from AD(H)D show a specific WISC-IV profile in comparison to subjects of the same age group without any mental disorder. The present study compares the cognitive profiles of male subjects with AD(H)D to those of a clinical control group. The benefits of applying an ADHD specific cognitive profile analysis to differential diagnostics are analyzed. The WISC-IV profiles of 50 male subjects with AD(H)D (8 to 15 years) were compared with the profiles of 54 male children and adolescents(7 to 16 years) with other mental disorders. In addition, subgroup differences within the AD(H)D group were investigated. Subjects with AD(H)D showed a significant lower processing speed than the control group. Within the AD(H)D group, patients with ADD showed the lowest speed index. There were no group differences in total IQ and other WISC-IV indexes. A WISC-IV profile analysis is not a suitable instrument to certainly confirm or exclude an AD(H)D diagnosis. Nevertheless, the results of the present study speak for considering the WISC-IV profile in the diagnosis of AD(H)D as it increases the sensitivity of the clinical diagnostic process and provides useful indicators for differential diagnosis.

  9. PERFORMANCE

    Directory of Open Access Journals (Sweden)

    M Cilli

    2014-10-01

    Full Text Available This study aimed to investigate the kinematic and kinetic changes when resistance is applied in horizontal and vertical directions, produced by using different percentages of body weight, caused by jumping movements during a dynamic warm-up. The group of subjects consisted of 35 voluntary male athletes (19 basketball and 16 volleyball players; age: 23.4 ± 1.4 years, training experience: 9.6 ± 2.7 years; height: 177.2 ± 5.7 cm, body weight: 69.9 ± 6.9 kg studying Physical Education, who had a jump training background and who were training for 2 hours, on 4 days in a week. A dynamic warm-up protocol containing seven specific resistance movements with specific resistance corresponding to different percentages of body weight (2%, 4%, 6%, 8%, 10% was applied randomly on non consecutive days. Effects of different warm-up protocols were assessed by pre-/post- exercise changes in jump height in the countermovement jump (CMJ and the squat jump (SJ measured using a force platform and changes in hip and knee joint angles at the end of the eccentric phase measured using a video camera. A significant increase in jump height was observed in the dynamic resistance warm-up conducted with different percentages of body weight (p 0.05. In jump movements before and after the warm-up, while no significant difference between the vertical ground reaction forces applied by athletes was observed (p>0.05, in some cases of resistance, a significant reduction was observed in hip and knee joint angles (p<0.05. The dynamic resistance warm-up method was found to cause changes in the kinematics of jumping movements, as well as an increase in jump height values. As a result, dynamic warm-up exercises could be applicable in cases of resistance corresponding to 6-10% of body weight applied in horizontal and vertical directions in order to increase the jump performance acutely.

  10. Return to Sport and Performance After Anterior Cruciate Ligament Reconstruction in National Football League Linemen.

    Science.gov (United States)

    Cinque, Mark E; Hannon, Charles P; Bohl, Daniel D; Erickson, Brandon J; Verma, Nikhil N; Cole, Brian J; Bach, Bernard R

    2017-06-01

    Tears of the anterior cruciate ligament (ACL) are common in the National Football League (NFL). The impact of these injuries on the careers of NFL linemen is unknown. To define the percentage of NFL linemen who return to sport (RTS) after ACL reconstruction, the mean time to RTS, and the impact on performance compared with matched controls. Cohort study; Level of evidence, 3. Data on NFL offensive and defensive linemen who sustained an ACL tear and underwent ACL reconstruction between 1980 and 2015 were analyzed. Players were identified through NFL team websites, publicly available injury reports, player profiles, and press releases. Demographics and mean in-game performance data preinjury and post-ACL reconstruction were recorded. A player was deemed to have returned to sport if he played in at least 1 NFL game after his ACL reconstruction. A healthy control group was selected to compare in-game performance data and was matched with the study group on several parameters. Overall, 73 NFL linemen met the inclusion criteria; 47 (64.3%) returned to play after ACL reconstruction (62.5% of offensive linemen, 65.9% of defensive linemen). All offensive linemen successfully returned to play the season after injury. No difference existed in number of seasons, total number of games played, mean number of games played, or mean number of games started per season when offensive linemen who RTS after ACL reconstruction were compared with matched controls (all P > .05). Among defensive linemen who RTS, most returned the season after injury (88.9%). There was no difference between defensive linemen who RTS after ACL reconstruction and matched controls in any performance metrics as an average over the remainder of their career (all P > .05). However, NFL defensive linemen who tore their ACL played fewer total seasons than matched controls (P = .020). Overall, 64.3% of NFL offensive and defensive linemen who undergo ACL reconstruction returned to play. Linemen who RTS do so at a

  11. Performance of the Patient-Reported Outcomes Measurement Information System 29-Item Profile in Rheumatoid Arthritis, Osteoarthritis, Fibromyalgia, and Systemic Lupus Erythematosus.

    Science.gov (United States)

    Katz, Patricia; Pedro, Sofia; Michaud, Kaleb

    2017-09-01

    The Patient-Reported Outcomes Measurement Information System (PROMIS) was developed to improve measurement of patient-reported outcomes. We examined performance of the 29-item PROMIS Profile (PROMIS-29) in persons with rheumatoid arthritis (RA), osteoarthritis (OA), fibromyalgia (FM), and systemic lupus erythematosus (SLE). Participants in the National Data Bank for Rheumatic Diseases completed the PROMIS-29, which includes 4-item forms for 7 PROMIS domains. Scales were scored and converted to T scores. Distributions of scale scores were examined, convergent and known-groups validity was tested, and differences in scores from online versus paper questionnaires were examined. Sample sizes were 4,346 for RA, 727 for OA, 241 for FM, and 240 for SLE. Participants were predominantly female, with a mean disease duration ≥20 years, and were ages ∼60 years. Large ceiling effects occurred for some PROMIS-29 scales. Correlations of PROMIS-29 scores with scales measuring similar constructs ranged from high to moderate for RA, OA, and SLE; correlations for FM were markedly lower for some scales. Consistent patterns of worsening PROMIS-29 scores with increasing disease severity or declining health status were observed. Differences in scores obtained by online versus paper questionnaires ranged from 0.3 to 2.2 points. Results provide guarded support for using the PROMIS-29 in these conditions. The PROMIS-29 4-item static forms appear to identify differences among levels of health and to measure constructs similar to those measured by legacy questionnaires. However, large ceiling effects suggest that measurement may be more precise at the "bad" ends of the scales, which may limit responsiveness, and differences by mode of administration appear to exist. © 2016, American College of Rheumatology.

  12. Establishing a protein expression profile database for the normal human pituitary gland using two-dimensional high-performance liquid chromatography combined with LTQ-Orbitrap mass spectrometry

    Institute of Scientific and Technical Information of China (English)

    Rong Xie; Wei Xu; Weimin Bao; Hang Liu; Luping Chen; Yiwen Shen; Jianhong Zhu

    2012-01-01

    In this study, we selected adult normal pituitary gland tissues from six patients during operations for pituitary microadenomas via the transsphenoidal approach for extended normal pituitary tissue resection around the tumor, and analyzed the protein expression of human normal pituitary using two-dimensional high-performance liquid chromatography combined with LTQ-Orbitrap mass spectrometry proteomics technology. The ten most highly expressed proteins in normal human pituitary were: alpha 3 type VI collagen isoform 5 precursor (abundance among tall pituitary proteins, 1.30%), fibrinogen beta chain preproprotein (0.99%), vimentin (0.73%), prolactin (0.69%), ATP synthase, H+ transporting and mitochondrial F1 complex beta subunit precursor (0.52%), keratin I (0.49%), growth hormone (0.45%), carbonic anhydrase I (0.40%), heat shock protein 90 kDa I (0.31%), and annexin V (0.30%). Based on the biological function classifications of these proteins, the top three categories by content were neuroendocrine proteins (abundance among all pituitary proteins, 40.1%), catalytic and metabolic proteins (28.3%), and cell signal transduction proteins (9.8%). Based on cell positioning classification, the top three categories were cell organelle (24.5%), membrane (20.8%), and cytoplasm (13.0%). Based on biological process classification, the top three categories of proteins are involved in physiological processes (42.9%), cellular processes (40.4%), and regulation of biological processes (9.1%). Our experimental findings indicate that a protein expression profile database of normal human pituitary can be precisely and efficiently established by proteomics technology.

  13. Physiological performance and differential expression profiling of genes associated with drought tolerance in root tissue of four contrasting varieties of two Gossypium species.

    Science.gov (United States)

    Singh, Ruchi; Pandey, Neha; Kumar, Anil; Shirke, Pramod A

    2016-01-01

    Root growth in drying soil is generally limited by a combination of mechanical impedance and water stress. As the major function of root tissue is water and nutrient uptake, so it imparts an important role in plant growth and stress management. Previously, we have studied physiological performance and expression profiling of gene associated with drought tolerance in leaf tissue of four cotton varieties. Here, we have further continued our studies with the root tissue of these varieties. The Gossypium hirsutum species JKC-770 is drought-tolerant and KC-2 is drought-sensitive, while Gossypium herbaceum species JKC-717 is drought-tolerant and RAHS-187 is drought-sensitive. JKC-770 and JKC-717 the drought-tolerant varieties showed a comparatively high glutathione-S-transferase, superoxide dismutase, proline along with their gene expression, and low malondialdehyde content indicating low membrane damage and better antioxidative defense under drought condition. The expression levels of cellulose synthase, xyloglucan:xyloglucosyl transferase, and glycosyl hydrolases suggest modulation in cell wall structure and partitioning of sugars towards osmoprotectants instead of cell wall biosynthesis in tolerant varieties. Heat shock proteins and serine/threonine protein phosphotases show upregulation under drought condition, which are responsible for temperature tolerance and protein phosphorylation, respectively. These effects many metabolic processes and may be playing a key role in drought tolerance and adaptability of JKC-770 towards drought tolerance. The long-term water use efficiency (WUE) estimated in terms of carbon isotope discrimination (∆(13)C) in the root tissues showed maximum depletion in the ∆(13)C values in JKC-770 variety, while minimum in RAHS-187 under drought stress with reference to their respective control, suggesting a high WUE in JKC-770 variety.

  14. Effects of dietary onion ( extract supplementation on performance, apparent total tract retention of nutrients, blood profile and meat quality of broiler chicks

    Directory of Open Access Journals (Sweden)

    Siska Aditya

    2017-02-01

    Full Text Available Objective This study was conducted to investigate the effect of dietary onion (Allium cepa extract (OE supplementation on growth performance, apparent total tract retention (ATTR, blood profile, carcass characteristics and meat quality in broilers. Methods Four hundred male broiler chicks (Ross 308, 3-d old were randomly allocated to four dietary treatments for 28 d feeding trial. Each treatment has five replications with 20 birds each. Four dietary treatments were designated according to the OE supplementation levels (0 as control, 5, 7.5, and 10 g of OE per kg of basal diet respectively. On d 28, a total of 20 birds from each treatment were subjected for ATTR, serum biochemical assay, carcass characteristic and organ weight measurement. Results Overall weight gain of OE 7.5 g/kg group was higher (p = 0.04 than control group. The ATTRs of dietary energy (p<0.01 and ether extract (p = 0.04 linearly increased with increasing levels of dietary OE. However, no difference in ATTR of dry matter and crude protein was evident. Furthermore, serum IgG concentration increased linearly (p<0.01 and quadratically (p = 0.03 with increasing OE supplementation. No differences in carcass dressing weight and amount of abdominal fat by treatments were observed. Also, the weight of organ including immune organ was not different among the treatments. The TBARS values of 10 d stored breast meat decreased linearly (p<0.01 and quadratically (p<0.01 with increasing dietary OE levels. The meat color was also affected, with lower (p<0.01 redness score in meats from OE supplemented groups. This study showed that dietary OE improved broiler weight gain presumably by increasing feed intake and ATTR of both energy and ether extract. The dietary OE increased serum IgG level and meat anti-oxidation capacity. Conclusion This study implies that the recommended level of dietary OE supplementation could be beneficial for improving broiler performance and meat quality.

  15. Effects of dietary onion (Allium cepa) extract supplementation on performance, apparent total tract retention of nutrients, blood profile and meat quality of broiler chicks

    Science.gov (United States)

    Aditya, Siska; Ahammed, Musabbir; Jang, Seong Hun; Ohh, Sang Jip

    2017-01-01

    Objective This study was conducted to investigate the effect of dietary onion (Allium cepa) extract (OE) supplementation on growth performance, apparent total tract retention (ATTR), blood profile, carcass characteristics and meat quality in broilers. Methods Four hundred male broiler chicks (Ross 308, 3-d old) were randomly allocated to four dietary treatments for 28 d feeding trial. Each treatment has five replications with 20 birds each. Four dietary treatments were designated according to the OE supplementation levels (0 as control, 5, 7.5, and 10 g of OE per kg of basal diet respectively). On d 28, a total of 20 birds from each treatment were subjected for ATTR, serum biochemical assay, carcass characteristic and organ weight measurement. Results Overall weight gain of OE 7.5 g/kg group was higher (p = 0.04) than control group. The ATTRs of dietary energy (p<0.01) and ether extract (p = 0.04) linearly increased with increasing levels of dietary OE. However, no difference in ATTR of dry matter and crude protein was evident. Furthermore, serum IgG concentration increased linearly (p<0.01) and quadratically (p = 0.03) with increasing OE supplementation. No differences in carcass dressing weight and amount of abdominal fat by treatments were observed. Also, the weight of organ including immune organ was not different among the treatments. The TBARS values of 10 d stored breast meat decreased linearly (p<0.01) and quadratically (p<0.01) with increasing dietary OE levels. The meat color was also affected, with lower (p<0.01) redness score in meats from OE supplemented groups. This study showed that dietary OE improved broiler weight gain presumably by increasing feed intake and ATTR of both energy and ether extract. The dietary OE increased serum IgG level and meat anti-oxidation capacity. Conclusion This study implies that the recommended level of dietary OE supplementation could be beneficial for improving broiler performance and meat quality. PMID:27809460

  16. Alleviation of chronic heat stress in broilers by dietary supplementation of betaine and turmeric rhizome powder: dynamics of performance, leukocyte profile, humoral immunity, and antioxidant status.

    Science.gov (United States)

    Akhavan-Salamat, Hossein; Ghasemi, Hossein Ali

    2016-01-01

    Heat stress (HS), one of the most serious climate problems of tropical and subtropical countries, negatively affects the production performance of broilers. Keeping this in view, the current study was aimed at elucidating the effects of supplementing betaine (Bet) and dried turmeric rhizome powder (TRP), either singly or in combination, on growth performance, leukocyte profile, humoral immunity, and antioxidant status in broilers kept under chronic HS. A total of 625 one-day-old Ross male chicks were randomly assigned to five treatment groups (5 replicates of 25 birds per replicate pen). From day 1, the birds were either kept at the thermoneutral zone (TN) or exposed to HS (33 ± 1°C) to the conclusion of study, day 42. THeat stress (HS), one of the most serious climate problems of tropical and subtropical countries, negatively affects the production performance of broilers. Keeping this in view, the current study was aimed at elucidating the effects of supplementing betaine (Bet) and dried turmeric rhizome powder (TRP), either singly or in combination, on growth performance, leukocyte profile, humoral immunity, and antioxidant status in broilers kept under chronic HS. A total of 625 one-day-old Ross male chicks were randomly assigned to five treatment groups (5 replicates of 25 birds per replicate pen). From day 1, the birds were either kept at the thermoneutral zone (TN) or exposed to HS (33 ± 1°C) to the conclusion of study, day 42. The treatment groups were as follows: thermoneutral control (TN-CON), HS-CON, HS-Bet, HS-TRP, and HS-BT (fed Bet and TRP). The results showed that decreases in body weight gain, feed intake, and increases in feed-to-gain ratio and mortality induced by HS were partially restored by dietary supplementation of Bet and TRP. The heterophil/lymphocyte ratio, total, and IgG antibody titers against sheep red blood cell for secondary responses in the HS-TRP and HS-BT groups were also similar to those of the broilers in the TN

  17. Changing the omega-6 to omega-3 fatty acid ratio in sow diets alters serum, colostrum, and milk fatty acid profiles, but has minimal impact on reproductive performance.

    Science.gov (United States)

    Eastwood, L; Leterme, P; Beaulieu, A D

    2014-12-01

    This experiment tested the hypothesis that reducing the omega-6 (n-6) to omega-3 (n-3) fatty acid (FA) ratio in sow diets will improve performance, characterized by increased litter size, decreased preweaning mortality, and improved growth performance. Second, we determined if the FA profile in sow and piglet blood, colostrum, and milk are altered when sows are fed diets with varied n-6:n-3 ratios and if the dietary FA ratio impacts circulating concentrations of IgG, IgA, eicosapentaenoic (EPA), or docosahexaenoic (DHA) acid. Sows (n=150) were assigned to 1 of 5 treatments (each divided into gestation and lactation diets) on d 80 of gestation. Period 1 (P1) is defined as d 80 of gestation to weaning and Period 2 (P2) refers to the subsequent breeding to weaning. Diets were wheat and barley based (5% crude fat) and treatments consisted of a control (tallow), 3 diets with plant oil-based n-6:n-3 ratios (9:1P, 5:1P, and 1:1P), and a 5:1 fish oil diet (5:1F). Litter size was unaffected by treatment during P1 and P2 (P>0.10). In P1, birth weight was unaffected by diet (P>0.10); however, weaning weight (P=0.019) and ADG from birth to weaning (P=0.011) were greatest for piglets born to 9:1P and 5:1P sows. During P2, 5:1F sows consumed 10% less feed during lactation (P=0.036), tended to have reduced piglet birth weights (P=0.052), and piglet weaning weight was reduced by 0.8 kg (P=0.040) relative to the other diets. Colostrum and piglet serum IgA and IgG concentrations were unaffected by diet (P>0.10). Serum n-3 FA were greatest in sows (Pdiets and in their offspring (P=0.014). Serum α-linolenic acid (ALA) was greatest in 1:1P sows and EPA and DHA were greatest in 5:1F sows (P0.10). Relative to piglets of sows consuming the control diet, EPA was 2.5-fold greater in the 1:1P group and 4-fold greater in 5:1F group (Pdiets with plant-based n-6:n-3 ratios of 5:1 or 1:1 did not impact performance relative to a control group but improved the conversion of ALA into EPA and

  18. Preinjury Psychological Status, Injury Severity and Postdeployment Posttraumatic Stress Disorder

    Science.gov (United States)

    2011-05-01

    from the United States Navy– Marine Corps Combat Trauma Registry. J Neurosurg. 2008;108(5):950-957. 29. Blanchard EB, Jones- Alexander J, Buckley TC...retro- spective study. Am J Psychiatry. 2006;163(4):733-734. 63. Reger MA, Gahm GA, Swanson RD, Duma SJ. Association between number of deployments to Iraq

  19. Effect of CLA supplementation to low-protein diets on the growth performance, carcass characteristics, plasma urea nitrogen concentration, and fatty acid profile in the meat of pigs

    Directory of Open Access Journals (Sweden)

    Manuel Martínez-Aispuro

    2014-10-01

    Full Text Available To analyze the effect of conjugated linoleic acid (CLA on the meat of pigs (0,1% and three crude protein (CP levels (nursery: 20.5, 16.0, 14.5%; growing: 16, 14.5, 11.5%; and finishing: 14.0, 12.5, 11% CP, studies were conducted with 36 hybrid (Yorkshire×Landrace×Duroc barrows (17.3-83.5 kg, which were individually penned and allotted in a completely randomized design in a factorial (2×3 arrangement for 84 d. The analysis by phases indicated that CP level affected some variables. Average daily gain, average daily feed intake, fat free lean gain, backfat thickness, longissimus muscle area and final body weight were reduced (P≤0.05 feeding the lowest CP diet in nursery and growing pigs. Plasma urea nitrogen concentration was also lower (P≤0.05 in the growing and finishing phases when fed the lowest CP level. The global analysis showed that all the analyzed variables (except feed gain ratio, lean meat percentage and plasma urea nitrogen concentration were reduced (P≤0.05 in the pigs fed low-protein diets; plasma urea nitrogen concentration tended to be lower (P=0.07 when CP was reduced. The fatty acid profile of the meat (semimembranosus and longissimus muscles indicated that CLA addition increased CLA isomers and total saturated fatty acids, and reduced the total monounsaturated fatty acids (P≤0.05. α-Linolenic acid was lowered in longissimus muscle of pigs fed LPD (P=0.08. These results indicated that reducing the crude protein concentration in the diet of fattening pigs from 20.5 to 16.0% in nursery phase; from 16.0 to 14.5% in growing stage; and from 14.0 to 12.5% in finishing pigs, did not negatively affect the growth performance, nor carcass characteristics. The results also showed that the addition of CLA did not improve pig response and the concentration of unsaturated fatty acids and total lipids altered the feeding LPD.

  20. Biotransformation and metabolic profile of buddleoside with human intestinal microflora by ultrahigh-performance liquid chromatography coupled to hybrid linear ion trap/orbitrap mass spectrometer.

    Science.gov (United States)

    Tao, Jin-Hua; Duan, Jin-Ao; Jiang, Shu; Qian, Yi-Yun; Qian, Da-Wei

    2016-07-01

    Buddleoside (also known as linarin) as the major flavonoid in Chrysanthemum morifolium Ramat., has been reported to possess a wide range of pharmacological activities. The human intestinal microbiota might have an important impact on drug metabolism and ultimately on the drug oral bioavailability. However, the interaction of the buddleoside with human intestinal bacteria remains unknown. In this study, the conversion of buddleoside by different bacteria from human feces was firstly investigated. A reliable, sensitive and rapid analytical method, ultra performance liquid chromatography was established and successfully applied to investigate the metabolites and metabolic profile of buddleoside by human intestinal bacteria. Among the isolated bacteria, four strains including Escherichia sp. 4, Escherichia sp. 34, Enterococcus sp. 45 and Bacillus sp. 46 showed more powerful conversion capability. Based on the accurate mass data and the characteristic MS(n) product ions, the parent and six metabolites were detected and tentatively identified compared with blank samples. The metabolites were produced by four main metabolic pathways including deglycosylation, acetylation, methylation and hydroxylation. Buddleoside could be firstly converted to its aglycon acacetin (M2) by the majority of the isolated intestinal bacteria. Subsequently, M2 was further metabolize to its methylated (M3), acetylated (M4), hydroxylated (M5) and hydrogenated product (M6). However, acacetin-7-glucosid (M1) was obtained only from the minor bacterial samples like Bacillus sp. 46. To further explain the metabolism of buddleoside, the β-d-glucosidase and α-l-rhamnosidase activities of four strains were analyzed. Bacillus sp. 46 could only produce α-l-rhamnosidase, while the other three strains showed two kinds of enzyme activities. Furthermore, the activities of α-l-rhamnosidase and β-d-glucosidase reached the highest level at 12-18h and 10-12h, respectively. The metabolic routes and metabolites

  1. Effects of dietary supplementation of modified zinc oxide on growth performance, nutrient digestibility, blood profiles, fecal microbial shedding and fecal score in weanling pigs.

    Science.gov (United States)

    Cho, Jin Ho; Upadhaya, Santi Devi; Kim, In Ho

    2015-06-01

    One hundred and forty piglets ((Landrace × Yorkshire) × Duroc, 21 day of age) with an initial weight of 6.50 ± 0.71 kg, were randomly allotted into four treatments to determine the effects of a modified form of zinc oxide (ZnO) on growth performance, nutrient digestibility, blood profiles, fecal microbial shedding and fecal score in weanling pigs. Dietary treatments were: (i) NC, negative control, basal diet containing zinc (Zn) from the premix; (ii) PC, positive control, basal diet containing Zn-free premix + 3000 ppm ZnO; (iii) H1, basal diet containing Zn-free premix + 3000 ppm ZnO (phase 1, days 1 to 14)/200 ppm modified ZnO (phase 2, days 15 to 42); (iv) H2, basal diet containing Zn-free premix + 300 ppm modified ZnO (phase 1)/200 ppm modified ZnO (phase 2). During days 1 to 14, average daily gains (ADG) were higher (P = 0.04) in PC, H1 and H2 groups than that in NC group. Overall, H1 treatment increased the ADG compared with NC (P = 0.05). On day 14, the alkaline phosphatase and plasma Zn concentration were increased (P = 0.01 and 0.04, respectively) in PC, H1 and H2 treatments compared with NC treatment. On days 14 and 42, the fecal Lactobacillus counts in NC group were lowest (P = 0.01, P = 0.04 respectively) among treatments. All supplemented groups showed lower (P = 0.03) fecal score than NC treatment on days 21 and 28. In conclusion, dietary supplementation with modified ZnO increased growth rates and reduced fecal scores in weanling pig. Modified ZnO could be used as a substitute to ZnO as a growth promoter and reduce Zn excretion to the environment because of the lower dosage. [Correction added on 3 February 2015, after first online publication: the initial weight of '6.50 ± 1.11 kg' has been replaced with '6.50 ± 0.71 kg' in the abstract.].

  2. Changes in milk fatty acid profile and animal performance in response to fish oil supplementation, alone or in combination with sunflower oil, in dairy ewes.

    Science.gov (United States)

    Toral, P G; Frutos, P; Hervás, G; Gómez-Cortés, P; Juárez, M; de la Fuente, M A

    2010-04-01

    Ruminant diet supplementation with sunflower oil (SO) and fish oil (FO) has been reported as a good strategy for enhancing some milk fat compounds such as conjugated linoleic acid (CLA) and n-3 polyunsaturated fatty acids in dairy cows, but no information is available regarding dairy sheep. In this work, ewe diet was supplemented with FO, alone or in combination with SO, with the aim of improving milk nutritional value and evaluating its effect on animal performance. Sixty-four Assaf ewes in mid lactation, fed a high-concentrate diet, were distributed in 8 lots of 8 animals each and assigned to 4 treatments (2 lots/treatment): no lipid supplementation (control) or supplementation with 20 g of SO/kg (SO), 10 g of FO/kg (FO), or 20 g of SO plus 10 g of FO/kg (SOFO). Milk production and composition, including a complete fatty acid profile, were analyzed on d 0, 3, 7, 14, 21, and 28 of treatments. Supplementation with FO tended to reduce dry matter intake compared with the control treatment (-15%), and its use in combination with SO (SOFO) resulted in a significant decrease in milk yield as well (-13%). All lipid supplements reduced milk protein content, and FO also reduced milk fat content by up to 21% alone (FO) and 27% in combination with SO (SOFO). Although the mechanisms involved in FO-induced milk fat depression are not yet well established, the observed increase in some milk trans-FA that are putative inhibitors of milk fat synthesis, such as trans-9,cis-11 CLA, and the 63% decrease in C18:0 (consistent with the theory of reduced milk fat fluidity) may be involved. When compared with the control, lipid supplementation remarkably improved the milk content of rumenic acid (cis-9,trans-11 CLA; up to 4-fold increases with SO and SOFO diets), whereas FO-containing diets also increased milk n-3 polyunsaturated fatty acids, mainly docosahexaenoic acid (with mean contents of 0.29 and 0.38% of total fatty acids for SOFO and FO, respectively), and reduced the n-6:n-3 FA

  3. Leadership Profiles.

    Science.gov (United States)

    Morgan, Robert M.; And Others

    1992-01-01

    Presents profiles of three leaders in the field of educational media and technology: Robert Mills Gagne, Florida State University; Robert Heinich, Indiana University; and Charles Francis Schuller, University of Georgia. (SLW)

  4. Profiling cancer

    DEFF Research Database (Denmark)

    Ciro, Marco; Bracken, Adrian P; Helin, Kristian

    2003-01-01

    In the past couple of years, several very exciting studies have demonstrated the enormous power of gene-expression profiling for cancer classification and prediction of patient survival. In addition to promising a more accurate classification of cancer and therefore better treatment of patients......, gene-expression profiling can result in the identification of novel potential targets for cancer therapy and a better understanding of the molecular mechanisms leading to cancer....

  5. Profiling cancer

    DEFF Research Database (Denmark)

    Ciro, Marco; Bracken, Adrian P; Helin, Kristian

    2003-01-01

    In the past couple of years, several very exciting studies have demonstrated the enormous power of gene-expression profiling for cancer classification and prediction of patient survival. In addition to promising a more accurate classification of cancer and therefore better treatment of patients......, gene-expression profiling can result in the identification of novel potential targets for cancer therapy and a better understanding of the molecular mechanisms leading to cancer....

  6. Dietary structured triacylglycerols containing docosahexaenoic acid given from birth affect visual and auditory performance and tissue fatty acid profiles of rats

    DEFF Research Database (Denmark)

    Christensen, M. M.; Lund, S. P.; Simonsen, L.;

    1998-01-01

    To examine whether it is possible to enhance the level of 22:6(n-3) in the central nervous system, newborn rats were fed dietary supplements containing oils with either specific or random triacylglycerol structure, but similar concentrations of polyunsaturated fatty acids. In the specific...... in metabolism of fatty acids resulting from their position in the dietary triacylglycerol molecule. The higher levers of 22:6(n-3) were accompanied by significantly lower levels of the long-chain (n-6) polyunsaturated fatty acids compared with the reference group. The fatty acid profiles, including the level...... of 22:6(n-3), in the retina phospholipids were not affected by the three different diets apart from a lower level of 20:4(n-6) in rats fed the experimental diets, indicating a strong tendency to maintain a high level of 22:6(n-3) in the retina. The changes in the fatty acid profiles did not result...

  7. Tropical-Forest Profiles and Biomass from TanDEM-X, Single-Baseline Interferometric SAR: InSAR Performance at Higher Frequencies and Bandwidths

    Science.gov (United States)

    Treuhaft, R. N.; Goncalves, F. G.; Neumann, M.; Keller, M. M.; Santos, J. R.

    2015-12-01

    The principal method for remotely sensing forest biomass, particularly high-biomass tropical forests, is to measure vertical structural properties of the forest and relate them to biomass. Interferometric SAR (InSAR) and lidar are the two principal technologies applied to this task. InSAR profile information is constrained in the traditional, look-averaged analysis, because it measures the vertical Fourier transform of the radar power at one and only one vertical frequency specified by the baseline. Lidar produces a full profile, including all Fourier frequencies—all vertical scales of fluctuation. In TanDEM-X data over tropical forests at the Tapajos National Forest, Brazil, we show the results of potentially improving InSAR's Fourier coverage. This is done by estimating many Fourier frequencies with a single baseline, based on the assumption that sampling of the phase height of small (~1.5 m x 2.5 m) looks of TanDEM-X is equivalent to sampling the vertical structure of the forest; a spatial ergodicity. We show a similarity between the distribution of InSAR look-phase-heights (LPH) and lidar and field profiles over 0.25-ha areas. Using Fourier transforms of the histogram of LPH over 0.25 ha areas, biomass estimation improved by about 17% over using InSAR coherence and mean forest height, making it competitive with some lidar results. The RMS of biomasses estimated about field biomass was 48 Mg/ha, with biomasses as high as 430 Mg/ha, and an average of 174 Mg/ha. Perhaps LPH distributions bear a similarity to lidar and field profiles because shorter wavelengths (~3 cm) can penetrate holes in the canopy to scatter off a sample of the vegetation with each look. This "hole mechanism" favors higher frequencies, which are able to penetrate smaller holes. Because they increase the number of look samples, higher bandwidths are also preferred.

  8. Nephron Toxicity Profiling via Untargeted Metabolome Analysis Employing a High Performance Liquid Chromatography-Mass Spectrometry-based Experimental and Computational Pipeline*

    Science.gov (United States)

    Ranninger, Christina; Rurik, Marc; Limonciel, Alice; Ruzek, Silke; Reischl, Roland; Wilmes, Anja; Jennings, Paul; Hewitt, Philip; Dekant, Wolfgang; Kohlbacher, Oliver; Huber, Christian G.

    2015-01-01

    Untargeted metabolomics has the potential to improve the predictivity of in vitro toxicity models and therefore may aid the replacement of expensive and laborious animal models. Here we describe a long term repeat dose nephrotoxicity study conducted on the human renal proximal tubular epithelial cell line, RPTEC/TERT1, treated with 10 and 35 μmol·liter−1 of chloroacetaldehyde, a metabolite of the anti-cancer drug ifosfamide. Our study outlines the establishment of an automated and easy to use untargeted metabolomics workflow for HPLC-high resolution mass spectrometry data. Automated data analysis workflows based on open source software (OpenMS, KNIME) enabled a comprehensive and reproducible analysis of the complex and voluminous metabolomics data produced by the profiling approach. Time- and concentration-dependent responses were clearly evident in the metabolomic profiles. To obtain a more comprehensive picture of the mode of action, transcriptomics and proteomics data were also integrated. For toxicity profiling of chloroacetaldehyde, 428 and 317 metabolite features were detectable in positive and negative modes, respectively, after stringent removal of chemical noise and unstable signals. Changes upon treatment were explored using principal component analysis, and statistically significant differences were identified using linear models for microarray assays. The analysis revealed toxic effects only for the treatment with 35 μmol·liter−1 for 3 and 14 days. The most regulated metabolites were glutathione and metabolites related to the oxidative stress response of the cells. These findings are corroborated by proteomics and transcriptomics data, which show, among other things, an activation of the Nrf2 and ATF4 pathways. PMID:26055719

  9. Metabolic profiling of five flavonoids from Dragon's Blood in human liver microsomes using high-performance liquid chromatography coupled with high resolution mass spectrometry.

    Science.gov (United States)

    Li, Yujuan; Zhang, Yushi; Wang, Rui; Wei, Lizhong; Deng, Yulin; Ren, Wei

    2017-05-01

    Although much is known about the pharmacological activities of Dragon's Blood (DB, a traditional Chinese herb), its metabolism in human liver microsomes (HLMs) and the cytochrome P450 (CYP) enzymes has not been studied. This study aims to identify the metabolic profile of five flavonoids (loureirin A, loureirin B, loureirin C, 7,4'-dihydroxyflavone and 5,7,4'-trihydroxyflavanone) from DB in HLMs as well as the CYP enzymes that are involved in the metabolism of them. High-resolution mass spectrometry was used to characterize the structures of their metabolites and 10 cDNA-expressed CYP enzymes (CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4 and CYP3A5) were used to verify which isozymes mediate in the metabolism of the metabolites. Totally, 29 metabolites including 10 metabolites of loureirin A, 10 metabolites of loureirin B, 4 metabolites of loureirin C, 2 metabolites of 7,4'-dihydroxyflavone and 3 metabolites of 5,7,4'-trihydroxyflavanone were elucidated and identified on the basis of the high-resolution MS(n) data. The metabolic profile of the five flavonoids in HLMs involved hydroxylation, oxidation and demethylation. Among them, hydroxylation was the predominant biotransformation of the five flavonoids in HLMs, occurring in combination with other metabolic reactions. Assay with recombinant P450s revealed that CYP2C9 and CYP2C19 played an important role in the hydroxylation of flavonoids in HLMs. To the best of our knowledge, this is the first in vitro evaluation of the metabolic profile of loureirin A, loureirin B, loureirin C, 7,4'-dihydroxyflavone and 5,7,4'-trihydroxyflavanone in HLMs. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. Profile summary.

    Science.gov (United States)

    2003-01-01

    All drugs appearing in the Adis Profile Summary table have been selected based on information contained in R&D Insight trade mark, a proprietary product of Adis International. The information in the profiles is gathered from the world's medical and scientific literature, at international conferences and symposia, and directly from the developing companies themselves. The emphasis of Drugs in R&D is on the clinical potential of new drugs, and selection of agents for inclusion is based on products in late-phase clinical development that have recently had a significant change in status.

  11. Enhanced performance of dye-sensitized solar cells based on TiO2 nanotube membranes using an optimized annealing profile.

    Science.gov (United States)

    Mohammadpour, F; Moradi, M; Lee, K; Cha, G; So, S; Kahnt, A; Guldi, D M; Altomare, M; Schmuki, P

    2015-01-31

    We use free-standing TiO2 nanotube membranes that are transferred onto FTO slides in front-side illuminated dye-sensitized solar cells (DSSCs). We investigate the key parameters for solar cell arrangement of self-ordered anodic TiO2 nanotube layers on the FTO substrate, namely the influence of the annealing procedure on the DSSC light conversion efficiency. The results show that using an optimal temperature annealing profile can significantly enhance the DSSC efficiency (in our case η = 9.8%), as it leads to a markedly lower density of trapping states in the tube oxide, and thus to strongly improved electron transport properties.

  12. Accelerated Profile HMM Searches.

    Directory of Open Access Journals (Sweden)

    Sean R Eddy

    2011-10-01

    Full Text Available Profile hidden Markov models (profile HMMs and probabilistic inference methods have made important contributions to the theory of sequence database homology search. However, practical use of profile HMM methods has been hindered by the computational expense of existing software implementations. Here I describe an acceleration heuristic for profile HMMs, the "multiple segment Viterbi" (MSV algorithm. The MSV algorithm computes an optimal sum of multiple ungapped local alignment segments using a striped vector-parallel approach previously described for fast Smith/Waterman alignment. MSV scores follow the same statistical distribution as gapped optimal local alignment scores, allowing rapid evaluation of significance of an MSV score and thus facilitating its use as a heuristic filter. I also describe a 20-fold acceleration of the standard profile HMM Forward/Backward algorithms using a method I call "sparse rescaling". These methods are assembled in a pipeline in which high-scoring MSV hits are passed on for reanalysis with the full HMM Forward/Backward algorithm. This accelerated pipeline is implemented in the freely available HMMER3 software package. Performance benchmarks show that the use of the heuristic MSV filter sacrifices negligible sensitivity compared to unaccelerated profile HMM searches. HMMER3 is substantially more sensitive and 100- to 1000-fold faster than HMMER2. HMMER3 is now about as fast as BLAST for protein searches.

  13. Quantitative profiling of PrP(Sc) peptides by high-performance liquid chromatography mass spectrometry to investigate the diversity of prions.

    Science.gov (United States)

    Gielbert, Adriana; Davis, Linda A; Sayers, A Robin; Tang, Yue; Hope, James; Sauer, Maurice J

    2013-05-01

    Prions are proteins that can exist in two (or more) folding states, a normal or cellular form and a series of infectious or prion forms, which are prone to aggregate. The prion form can induce conversion of the cellular form and so transmit phenotypic effects of this structural rearrangement within and between cells and organisms. The conversion of PrP(C), the mammalian prion glycoprotein, to its prion form, PrP(Sc), in the brain is a precursor to progressive neurological degeneration, and the various folded forms of PrP(Sc) (defined by the size and glycosylation of protease-resistant core peptides of the PrP aggregates, PrP(res)) are characteristic of a particular neurodegenerative phenotype or prion disease. Here, quantitative multiplex mass spectrometry was used for N-terminal amino acid profiling (N-TAAP) of PrP(res) from sheep affected by scrapie, the prion disease of small ruminants, to rapidly assess the diversity of prions within particular flocks. In 29 cases, PrP(res) concentrations varied from below the limit of detection (350 fmol/g) to 15 pmol/g wet brain. Although most had a single N-TAAP profile, two novel variants were identified: one common to the ARH/ARQ animals in this study and one in an animal of the wild-type sheep PrP genotype (ARQ/ARQ).

  14. Practical Differential Profiling

    Energy Technology Data Exchange (ETDEWEB)

    Schulz, M; De Supinski, B R

    2007-02-04

    Comparing performance profiles from two runs is an essential performance analysis step that users routinely perform. In this work we present eGprof, a tool that facilitates these comparisons through differential profiling inside gprof. We chose this approach, rather than designing a new tool, since gprof is one of the few performance analysis tools accepted and used by a large community of users. eGprof allows users to 'subtract' two performance profiles directly. It also includes callgraph visualization to highlight the differences in graphical form. Along with the design of this tool, we present several case studies that show how eGprof can be used to find and to study the differences of two application executions quickly and hence can aid the user in this most common step in performance analysis. We do this without requiring major changes on the side of the user, the most important factor in guaranteeing the adoption of our tool by code teams.

  15. Dose-response of supplementing marine algae (Schizochytrium spp.) on production performance, fatty acid profiles, and wool parameters of growing lambs.

    Science.gov (United States)

    Meale, S J; Chaves, A V; He, M L; McAllister, T A

    2014-05-01

    Microalgae are the original source of docosahexaenoic acid (DHA; 22:6n-3) in the marine food chain, and its inclusion in animal feeds has been considered as a means of increasing the DHA level in foods of animal origin. As such, this study aimed to investigate the effects of supplementing an algal meal, high in DHA derived from Schizochytrium spp. (DHA-G), in the diet of Canadian Arcott lambs, on growth, carcass characteristics, wool production, and fatty acid (FA) profiles of subcutaneous adipose tissues (SAT), perirenal adipose tissues (PAT), and skirt muscle (SM). Forty-four lambs were randomly assigned to dietary treatments. Diets consisted of a pelleted, barley-based finishing diet with DHA-G supplemented at 0, 1, 2, or 3% DM as a replacement for flax oil and barley grain. Feed deliveries and orts were recorded daily. Lambs were weighed weekly and slaughtered once they reached ≥ 45 kg live weight. Carcass characteristics, ruminal pH, and liver weights were determined at slaughter. Wool yield was determined on mid-side patches of 100 cm(2) shorn at d 0 and on the day before slaughter (d 105 or 140). Dye bands were used to determine wool growth, fiber diameter, and staple length. Adipose tissues and SM samples were taken at slaughter and analyzed for FA profiles. Data were analyzed using mixed procedure in SAS with orthogonal contrasts testing for linear, quadratic, or cubic responses to increasing levels of DHA-G. Daily DMI, ADG, and G:F were similar as were wool quality and yield (P > 0.05). Carcass characteristics were generally unaffected (P > 0.05), except for body wall thickness (mm), which showed a quadratic response (P = 0.01) with increasing DHA-G. The concentration of eicosapentaenoic acid (EPA; 20:5n-6; mg/100 g fresh tissue) linearly increased (P PAT (P = 0.01) as DHA-G increased. These results indicate that DHA-G can be successfully included in the diets of growing lambs, up to 3% DM, with the potential to improve carcass characteristics and the

  16. Success Profiling: A Methodological Perspective on the Interactive Nature of Success Predictors on Student Performance at an Open and Distance Learning Institution

    Science.gov (United States)

    Muller, Helene; Swanepoel, Elana; De Beer, Andreas

    2010-01-01

    The drive to improve the academic performance of students at an open and distance learning (ODL) institution has resulted in the incorporation of a blended learning component, namely satellite classes, in the learning strategy to enhance the academic performance of first year diploma students in Business Management and Management. Monitoring this…

  17. Global electricity company profiles

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-31

    Global Electricity Company Profiles examines the operations and strategies of 60 of the leading electricity companies in the world. Through its analysis of the key players, the report provides a comprehensive review of the current state of the global electricity industry. Using electricity sales as its criteria, the most successful companies are compared in terms of their national, regional and global importance. Global Electricity Company Profiles provides an outline of each company, its structure and operations, as well as key financial data. The detailed performance benchmarking and review of expectations for future development for each individual company provide a wealth of invaluable strategic information not available elsewhere. (author)

  18. Profiling of triacylglycerols in plant oils by high-performance liquid chromatography-atmosphere pressure chemical ionization mass spectrometry using a novel mixed-mode column.

    Science.gov (United States)

    Hu, Na; Wei, Fang; Lv, Xin; Wu, Lin; Dong, Xu-Yan; Chen, Hong

    2014-12-01

    In this investigation, a rapid and high-throughput method for profiling of TAGs in plant oils by liquid chromatography using a single column coupled with atmospheric pressure chemical ionization (APCI) mass spectrometry was reported. A novel mixed-mode phenyl-hexyl chromatographic column was employed in this separation system. The phenyl-hexyl column could provide hydrophobic interactions as well as π-π interactions. Compared with two traditionally columns used in TAG separation - the C18 column and silver-ion column, this column exhibited much higher selectivity for the separation of TAGs with great efficiency and rapid speed. By comparison with a novel mix-mode column (Ag-HiSep OTS column), which can also provide both hydrophobic interactions as well as π-π interactions for the separation of TAGs, phenyl-hexyl column exhibited excellent stability. LC method using phenyl-hexyl column coupled with APCI-MS was successfully applied for the profiling of TAGs in soybean oils, peanut oils, corn oils, and sesame oils. 29 TAGs in peanut oils, 22 TAGs in soybean oils, 19 TAGs in corn oils, and 19 TAGs in sesame oils were determined and quantified. The LC-MS data was analyzed by barcodes and principal component analysis (PCA). The resulting barcodes constitute a simple tool to display differences between different plant oils. Results of PCA also enabled a clear identification of different plant oils. This method provided an efficient and convenient chromatographic technology for the fast characterization and quantification of complex TAGs in plant oils at high selectivity. It has great potential as a routine analytical method for analysis of edible oil quality and authenticity control.

  19. Targeting high-performance liquid chromatography-high-resolution mass spectrometry-solid-phase extraction-nuclear magnetic resonance analysis with high-resolution radical scavenging profiles - bioactive secondary metabolites from the endophytic fungus Penicillium namyslowskii

    DEFF Research Database (Denmark)

    Wubshet, Sileshi Gizachew; Nyberg, Nils; Tejesvi, Mysore V.

    2013-01-01

    -HRMS-SPE-NMR, for identification of anti-oxidative secondary metabolites. This revealed the two chromatographic peaks with the highest relative response in the radical scavenging profile to be griseophenone C and peniprequinolone. The HPLC-HRMS-SPE-NMR analysis was performed in the tube-transfer mode using a cryogenically cooled.......e., dechlorogriseofulvin, dechlorodehydrogriseofulvin, griseofulvin, dehydrogriseofulvin, mevastatin acid, and mevastatin. The high mass sensitivity of the 1.7-mm cryogenically cooled NMR probe allowed for the first time acquisition of direct detected 13C NMR spectra of fungal metabolites, i.e., dechlorogriseofulvin...

  20. Analysis of Serum Metabolic Profile by Ultra-performance Liquid Chromatography-mass Spectrometry for Biomarkers Discovery: Application in a Pilot Study to Discriminate Patients with Tuberculosis

    Directory of Open Access Journals (Sweden)

    Shuang Feng

    2015-01-01

    Full Text Available Background: Tuberculosis (TB is a chronic wasting inflammatory disease characterized by multisystem involvement, which can cause metabolic derangements in afflicted patients. Metabolic signatures have been exploited in the study of several diseases. However, the serum that is successfully used in TB diagnosis on the basis of metabolic profiling is not by much. Methods: Orthogonal partial least-squares discriminant analysis was capable of distinguishing TB patients from both healthy subjects and patients with conditions other than TB. Therefore, TB-specific metabolic profiling was established. Clusters of potential biomarkers for differentiating TB active from non-TB diseases were identified using Mann-Whitney U-test. Multiple logistic regression analysis of metabolites was calculated to determine the suitable biomarker group that allows the efficient differentiation of patients with TB active from the control subjects. Results: From among 271 participants, 12 metabolites were found to contribute to the distinction between the TB active group and the control groups. These metabolites were mainly involved in the metabolic pathways of the following three biomolecules: Fatty acids, amino acids, and lipids. The receiver operating characteristic curves of 3D, 7D, and 11D-phytanic acid, behenic acid, and threoninyl-γ-glutamate exhibited excellent efficiency with area under the curve (AUC values of 0.904 (95% confidence interval [CI]: 0863-0.944, 0.93 (95% CI: 0.893-0.966, and 0.964 (95% CI: 00.941-0.988, respectively. The largest and smallest resulting AUCs were 0.964 and 0.720, indicating that these biomarkers may be involved in the disease mechanisms. The combination of lysophosphatidylcholine (18:0, behenic acid, threoninyl-γ-glutamate, and presqualene diphosphate was used to represent the most suitable biomarker group for the differentiation of patients with TB active from the control subjects, with an AUC value of 0.991. Conclusion: The

  1. Kinetic performance and energy profile in a roller coaster electron transfer chain: a study of modified tetraheme-reaction center constructs.

    Science.gov (United States)

    Alric, Jean; Lavergne, Jérôme; Rappaport, Fabrice; Verméglio, André; Matsuura, Katsumi; Shimada, Keizo; Nagashima, Kenji V P

    2006-03-29

    In many electron-transfer proteins, the arrangement of cofactors implies a succession of uphill and downhill steps. The kinetic implications of such arrangements are examined in the present work, based on a study of chimeric photosynthetic reaction centers obtained by expressing the tetraheme subunit from Blastochloris viridis in another purple bacterium, Rubrivivax gelatinosus. Site-directed mutations of the environment of heme c559, which is the immediate electron donor to the primary donor P, induced modifications of this heme's midpoint potential over a range of 400 mV. This resulted in shifts of the apparent midpoint potentials of the neighboring carriers, yielding estimates of the interactions between redox centers. At both extremities of the explored range, the energy profile of the electron-transfer chain presented an additional uphill step, either downstream or upstream from c559. These modifications caused conspicuous changes of the electron-transfer rate across the tetraheme subunit, which became approximately 100-fold slower in the mutants where the midpoint potential of c559 was lowest. A theoretical analysis of the kinetics is presented, predicting a displacement of the rate-limiting step when lowering the potential of c559. A reasonable agreement with the data was obtained when combining this treatment with the rates predicted by electron transfer theory for the individual rate constants.

  2. Establishing Normative Profiles of High-level Football Players’ Match Performance%高水平足球运动员比赛表现标准化档案的创建

    Institute of Scientific and Technical Information of China (English)

    刘鸿优; 易清; 康辉

    2015-01-01

    In the field of sport performance,normative profile could be defined as a chart or file that could be used to evaluate or/and compare all ( or some ) match performance indicators of different players and teams. Employing the standard-score transferring and radar-chart plotting method,the current study intended to use the match performance statistics of 13 technical and tactical indicators of 10 players from Real Madrid during the season 2011 2012 to estab-lish normative profiles of individual players,different players from distant or similar positions,and discussed the impli-cates and significances of these profiles. Setting up this kind of profile for the own team can provide prompt feedback to players and coaches and could be used as guidance to improve players’ performances and to assess players’ status;setting up profiles of upcoming opponents can help coaches and players know the strengths and weaknesses of the op-positions,thus they can carry out proper training programs and make appropriate match strategies.%体育比赛表现分析中的标准化档案( Normative Profiles)是指一套可以直接用来评定和比较球员或球队在比赛中的各项(或某几项)体能指标(如心率、跑动距离等)、技战术指标(如传球、射门等)特征的图表或文档。本研究以皇家马德里足球俱乐部的10名运动员在20112012赛季西班牙足球甲级联赛中的13项比赛技战术表现指标为研究对象,采取标准化分数转换的数理统计方法,将标准化之后的每个运动员的各项指标的均值、小四分位数和大四分位数投到同一雷达图内,建立了同一球员、不同位置球员和同一(或类似)位置不同球员的比赛技战术行为标准化档案,并阐述了各类档案的意义与实践价值。对自身球队进行标准化档案创建,可以为运动员、教练员对自身的表现提供直观而及时的反馈;而对将来的对手球队进行档案创建,则可以运

  3. Analytical Method for Sugar Profile in Pet Food and Animal Feeds by High-Performance Anion-Exchange Chromatography with Pulsed Amperometric Detection.

    Science.gov (United States)

    Ellingson, David J; Anderson, Phillip; Berg, Daniel P

    2016-01-01

    There is a need for a standardized, accurate, rugged, and consistent method to measure for sugars in pet foods and animal feeds. Many traditional standard sugar methods exist for other matrixes, but when applied in collaborative studies there was poor agreement and sources of error identified with those standard methods. The advancement in technology over the years has given us the ability to improve on these standard methods of analysis. A method is described here that addresses these common issues and was subjected to a single-laboratory validation to assess performance on a wide variety of pet foods and animal feeds. Of key importance to the method performance is the sample preparation before extraction, type of extraction solvent, postextraction cleanup, and, finally, optimized chromatography using high-performance anion exchange chromatography with pulsed amperometric detection. The results obtained from the validation demonstrate how typical issues seen with these matrixes can influence performance of sugar analysis. The results also demonstrate that this method is fit-for-purpose and can meet the challenges of sugar analysis in pet food and animal feeds to lay the foundation for a standardized method of analysis.

  4. An Inter-Correlational Study of the Reading Components in Profiling and Generating a Cognitive Equation for the Reading Performance of Students with Autism

    Science.gov (United States)

    Elangovan, Saranya; Chia, Noel Kok Hwee

    2013-01-01

    Reading is a multifaceted process consisting of many interacting components. A plethora of research is available on reading. Yet, there is inadequate exploration, which ascertains the effects of the interaction of different reading components and how they affect the reading performance of students with autism. This inter-correlational research…

  5. Tropospheric ozone profiles by DIAL at Maïdo Observatory (Reunion Island): system description, instrumental performance and result comparison with ozone external data set

    Science.gov (United States)

    Duflot, Valentin; Baray, Jean-Luc; Payen, Guillaume; Marquestaut, Nicolas; Posny, Francoise; Metzger, Jean-Marc; Langerock, Bavo; Vigouroux, Corinne; Hadji-Lazaro, Juliette; Portafaix, Thierry; De Mazière, Martine; Coheur, Pierre-Francois; Clerbaux, Cathy; Cammas, Jean-Pierre

    2017-09-01

    In order to recognize the importance of ozone (O3) in the troposphere and lower stratosphere in the tropics, a DIAL (differential absorption lidar) tropospheric O3 lidar system (LIO3TUR) was developed and installed at the Université de la Réunion campus site (close to the sea) on Reunion Island (southern tropics) in 1998. From 1998 to 2010, it acquired 427 O3 profiles from the low to the upper troposphere and has been central to several studies. In 2012, the system was moved up to the new Maïdo Observatory facility (2160 m a.m.s.l. - metres above mean sea level) where it started operation in February 2013. The current system (LIO3T) configuration generates a 266 nm beam obtained with the fourth harmonic of a Nd:YAG laser sent into a Raman cell filled up with deuterium (using helium as buffer gas), generating the 289 and 316 nm beams to enable the use of the DIAL method for O3 profile measurements. The optimal range for the actual system is 6-19 km a.m.s.l., depending on the instrumental and atmospheric conditions. For a 1 h integration time, vertical resolution varies from 0.7 km at 6 km a.m.s.l. to 1.3 km at 19 km a.m.s.l., and mean uncertainty within the 6-19 km range is between 6 and 13 %. Comparisons with eight electrochemical concentration cell (ECC) sondes simultaneously launched from the Maïdo Observatory show good agreement between data sets with a 6.8 % mean absolute relative difference (D) between 6 and 17 km a.m.s.l. (LIO3T lower than ECC). Comparisons with 37 ECC sondes launched from the nearby Gillot site during the daytime in a ±24 h window around lidar shooting result in a 9.4 % D between 6 and 19 km a.m.s.l. (LIO3T lower than ECC). Comparisons with 11 ground-based Network for Detection of Atmospheric Composition Change (NDACC) Fourier transform infrared (FTIR) spectrometer measurements acquired during the daytime in a ±24 h window around lidar shooting show good agreement between data sets with a D of 11.8 % for the 8.5-16 km partial column

  6. Tropospheric ozone profiles by DIAL at Maïdo Observatory (Reunion Island: system description, instrumental performance and result comparison with ozone external data set

    Directory of Open Access Journals (Sweden)

    V. Duflot

    2017-09-01

    Full Text Available In order to recognize the importance of ozone (O3 in the troposphere and lower stratosphere in the tropics, a DIAL (differential absorption lidar tropospheric O3 lidar system (LIO3TUR was developed and installed at the Université de la Réunion campus site (close to the sea on Reunion Island (southern tropics in 1998. From 1998 to 2010, it acquired 427 O3 profiles from the low to the upper troposphere and has been central to several studies. In 2012, the system was moved up to the new Maïdo Observatory facility (2160 m a.m.s.l. – metres above mean sea level where it started operation in February 2013. The current system (LIO3T configuration generates a 266 nm beam obtained with the fourth harmonic of a Nd:YAG laser sent into a Raman cell filled up with deuterium (using helium as buffer gas, generating the 289 and 316 nm beams to enable the use of the DIAL method for O3 profile measurements. The optimal range for the actual system is 6–19 km a.m.s.l., depending on the instrumental and atmospheric conditions. For a 1 h integration time, vertical resolution varies from 0.7 km at 6 km a.m.s.l. to 1.3 km at 19 km a.m.s.l., and mean uncertainty within the 6–19 km range is between 6 and 13 %. Comparisons with eight electrochemical concentration cell (ECC sondes simultaneously launched from the Maïdo Observatory show good agreement between data sets with a 6.8 % mean absolute relative difference (D between 6 and 17 km a.m.s.l. (LIO3T lower than ECC. Comparisons with 37 ECC sondes launched from the nearby Gillot site during the daytime in a ±24 h window around lidar shooting result in a 9.4 % D between 6 and 19 km a.m.s.l. (LIO3T lower than ECC. Comparisons with 11 ground-based Network for Detection of Atmospheric Composition Change (NDACC Fourier transform infrared (FTIR spectrometer measurements acquired during the daytime in a ±24 h window around lidar shooting show good agreement between data

  7. Quantum profiles

    CERN Document Server

    Bernstein, Jeremy

    1991-01-01

    For the prominent science writer Jeremy Bernstein, the profile is the most congenial way of communicating science. Here, in what he labels a "series of conversations carried on in the reader's behalf and my own," he evokes the tremendous intellectual excitement of the world of modern physics, especially the quantum revolution. Drawing on his well-known talent for explaining the most complex scientific ideas for the layperson, Bernstein gives us a lively sense of what the issues of quantum mechanics are and of various ways in which individual physicists approached them.The author begins this se

  8. Inclusion of sunflower seed and wheat dried distillers' grains with solubles in a red clover silage-based diet enhances steers performance, meat quality and fatty acid profiles.

    Science.gov (United States)

    Mapiye, C; Aalhus, J L; Turner, T D; Vahmani, P; Baron, V S; McAllister, T A; Block, H C; Uttaro, B; Dugan, M E R

    2014-12-01

    The current study compared beef production, quality and fatty acid (FA) profiles of yearling steers fed a control diet containing 70 : 30 red clover silage (RCS) : barley-based concentrate, a diet containing 11% sunflower seed (SS) substituted for barley, and diets containing SS with 15% or 30% wheat dried distillers' grain with solubles (DDGS). Additions of DDGS were balanced by reductions in RCS and SS to maintain crude fat levels in diets. A total of two pens of eight animals were fed per diet for an average period of 208 days. Relative to the control diet, feeding the SS diet increased (P<0.05) average daily gain, final live weight and proportions of total n-6 FA, non-conjugated 18:2 biohydrogenation products (i.e. atypical dienes) with the first double bond at carbon 8 or 9 from the carboxyl end, conjugated linoleic acid isomers with the first double bond from carbon 7 to 10 from the carboxyl end, t-18:1 isomers, and reduced (P<0.05) the proportions of total n-3 FA, conjugated linolenic acids, branched-chain FA, odd-chain FA and 16:0. Feeding DDGS-15 and DDGS-30 diets v. the SS diet further increased (P<0.05) average daily gains, final live weight, carcass weight, hot dressing percentage, fat thickness, rib-eye muscle area, and improved instrumental and sensory panel meat tenderness. However, in general feeding DGGS-15 or DDGS-30 diets did not change FA proportions relative to feeding the SS diet. Overall, adding SS to a RCS-based diet enhanced muscle proportions of 18:2n-6 biohydrogenation products, and further substitutions of DDGS in the diet improved beef production, and quality while maintaining proportions of potentially functional bioactive FA including vaccenic and rumenic acids.

  9. Development of a High-Performance, Low-Profile Translation Table with Wire Feedthrough for a Deep Space CubeSat

    Science.gov (United States)

    Few, Alex

    2016-01-01

    NEAScout, a 6U cubesat and secondary payload on NASA's EM-1, will use an 85 sq m solar sail to travel to a near-earth asteroid at about 1 Astronomical Unit (about 1.5 x 10(exp 8) km) for observation and reconnaissance1. A combination of reaction wheels, reaction control system, and a slow rotisserie roll about the solar sail's normal axis were expected to handle attitude control and adjust for imperfections in the deployed sail during the 2.5-year mission. As the design for NEAScout matured, one of the critical design parameters, the offset in the center of mass and center of pressure (CP/CM offset), proved to be sub-optimal. After significant mission and control analysis, the CP/CM offset was accommodated by the addition of a new subsystem to NEAScout. This system, called the Active Mass Translator (AMT), would reside near the geometric center of NEAScout and adjust the CM by moving one portion of the flight system relative to the other. The AMT was given limited design space - 17 mm of the vehicle's assembly height-and was required to generate +/-8 cm by +/-2 cm translation to sub-millimeter accuracy. Furthermore, the design must accommodate a large wire bundle of small gage, single strand wire and coax cables fed through the center of the mechanism. The bend radius, bend resistance, and the exposure to deep space environment complicates the AMT design and operation and necessitated a unique design to mitigate risks of wire bundle damage, binding, and cold-welding during operation. This paper will outline the design constraints for the AMT, discuss the methods and reasoning for design, and identify the lessons learned through the designing, breadboarding and testing for the low-profile translation stages with wire feedthrough capability.

  10. Influence of in ovo injection and subsequent provision of silver nanoparticles on growth performance, microbial profile, and immune status of broiler chickens

    DEFF Research Database (Denmark)

    Pineda, Lane; Sawosz, Ewa; Lauridsen, Charlotte

    2012-01-01

    as an alternative antimicrobial growth-promoting supplement for broiler chickens was investigated. Methods: On day 1 of incubation, two groups of fertile eggs were injected with colloidal silver nanoparticles 10 mg/kg or 20 mg/kg. A third group was not injected and designated as a control group. At day 7 post...... bacteria, and immunoglobulin levels in broiler chickens. Silver nanoparticles are a potent antimicrobial agent for use in these birds. However, their activity and impact on growth performance should be explored further in a commercial poultry production setting....

  11. Radiomic Profiling of Glioblastoma: Identifying an Imaging Predictor of Patient Survival with Improved Performance over Established Clinical and Radiologic Risk Models.

    Science.gov (United States)

    Kickingereder, Philipp; Burth, Sina; Wick, Antje; Götz, Michael; Eidel, Oliver; Schlemmer, Heinz-Peter; Maier-Hein, Klaus H; Wick, Wolfgang; Bendszus, Martin; Radbruch, Alexander; Bonekamp, David

    2016-09-01

    Purpose To evaluate whether radiomic feature-based magnetic resonance (MR) imaging signatures allow prediction of survival and stratification of patients with newly diagnosed glioblastoma with improved accuracy compared with that of established clinical and radiologic risk models. Materials and Methods Retrospective evaluation of data was approved by the local ethics committee and informed consent was waived. A total of 119 patients (allocated in a 2:1 ratio to a discovery [n = 79] or validation [n = 40] set) with newly diagnosed glioblastoma were subjected to radiomic feature extraction (12 190 features extracted, including first-order, volume, shape, and texture features) from the multiparametric (contrast material-enhanced T1-weighted and fluid-attenuated inversion-recovery imaging sequences) and multiregional (contrast-enhanced and unenhanced) tumor volumes. Radiomic features of patients in the discovery set were subjected to a supervised principal component (SPC) analysis to predict progression-free survival (PFS) and overall survival (OS) and were validated in the validation set. The performance of a Cox proportional hazards model with the SPC analysis predictor was assessed with C index and integrated Brier scores (IBS, lower scores indicating higher accuracy) and compared with Cox models based on clinical (age and Karnofsky performance score) and radiologic (Gaussian normalized relative cerebral blood volume and apparent diffusion coefficient) parameters. Results SPC analysis allowed stratification based on 11 features of patients in the discovery set into a low- or high-risk group for PFS (hazard ratio [HR], 2.43; P = .002) and OS (HR, 4.33; P radiologic (OS: IBS, 0.175; C index, 0.603; PFS: IBS, 0.149; C index, 0.554) and clinical risk models (OS: IBS, 0.161, C index, 0.640; PFS: IBS, 0.139; C index, 0.599). The performance of the SPC analysis model was further improved when combined with clinical data (OS: IBS, 0.142; C index, 0.696; PFS: IBS, 0.132; C

  12. Effect of oleic and conjugated linoleic acid in the diet of broiler chickens on the live growth performances, carcass traits and meat fatty acid profile

    Directory of Open Access Journals (Sweden)

    Stefano Rapaccini

    2010-01-01

    Full Text Available Olive oil and CLA enriched olive oil were compared with each other in a growth trial with broiler chickens, as energy supplements to the diet. A commercial CLA blend was used at the level of 1 kg per 100 kg mixed integrated feed. Two hundred and forty commercial hybrid broilers (Ross 308 were randomly subdivided and allotted to 8 pens of 30 birds each. Four pens of birds were fed the olive oil diet and considered the control group; the other 4 pens were fed the olive oil supplemented with CLA and considered the treated group. The experiment lasted 47 days. The live performance of the treated birds resulted different from the performance of the control ones: the final body weight was slightly lighter (2.544 kg vs 2.639 kg; P≤0.05 with a lower feed intake (4.886 kg feed vs 4.998 kg, P≤0.05 and, of course, an almost perfectly overlapping feed/gain ratio (1.90 vs 1.91. The fatty acid composition of the breast fat of the CLA treated birds resulted enriched by the two major CLA isomers, trans 10 cis 12 and cis 9 trans 11, whereas oleic acid and the linoleic, linolenic and arachidonic polyunsaturated acids showed a decrease (P≤0.05. CLA appears a recommendable ingredient in the diets of broilers as it improves the beneficial characteristics of poultry meat.

  13. On-line high-performance liquid chromatography-fluorescence detection-electrospray ionization-mass spectrometry profiling of human milk oligosaccharides derivatized with 2-aminoacridone.

    Science.gov (United States)

    Galeotti, Fabio; Coppa, Giovanni V; Zampini, Lucia; Maccari, Francesca; Galeazzi, Tiziana; Padella, Lucia; Santoro, Lucia; Gabrielli, Orazio; Volpi, Nicola

    2012-11-01

    A high-resolution normal-phase high-performance liquid chromatography-fluorescence detection-electrospray ionization-mass spectrometry separation and structural characterization of the main oligosaccharides along with lactose from human milk samples is described. A total of 22 commercially available oligosaccharides were fluorotagged with 2-aminoacridone and separated on an amide column and identified on the basis of their retention times and mass spectra. Derivatized species having mass lower than approximately 800 to 900 exhibited mainly [M-H](-1) anions, oligomers with mass up to approximately 1000 to 1100 were represented by both [M-H](-1) and [M-2H](-2) anions, and oligomers greater than approximately 1200 to 1300 were characterized by a charge state of -3. Furthermore, the retention times were directly related to the glycans' molecular mass. Human milk samples from the four groups of donors (Se±/Le±) were analyzed for their composition and amount of free oligosaccharides after rapid and simple prepurification and derivatization steps also in the presence of lactose in high content. This analytical approach enabled us to perform the determination of species not detected by traditional techniques, such as sialic acid, as well as of species present in low content easily mistaken with other peaks. Finally, labeled human milk oligosaccharides were analyzed without any interference from excess fluorophore or interference from proteins, peptides, salts, and other impurities normally present in this complex biological fluid.

  14. Role of aeration intensity on performance and microbial community profiles in a sequencing batch reaction kettle (SBRK) for wastewater nutrients rapid removal.

    Science.gov (United States)

    Xin, Xiaodong; He, Junguo; Wang, Yuefei; Feng, Jinghan; Qiu, Wei

    2016-02-01

    A lab-scale SBRK was operated to investigate the effects of aeration intensity on the system performance and microbial community dynamics within it. Results showed that the sewage nutrients was removed rapidly (just about 3-6h) with the aeration intensity increasing from 0 to 0.6MPa. Average effluent parameters were: COD below 50mg/L, NH4(+)-N less than 1mg/L, 1.5-4.5mg/L for nitrate and TP below 0.5mg/L. The highest community similarity and diversity emerged simultaneously with the aeration pressure rising from 0.2 to 0.4MPa, which was regarded as the optimal aeration intensity range. Microbial community shifted obviously and the function species of Comamonadaceae, Dechloromonas, Flavobacterium and Nitrospira dominated in the corresponding communities. RDA indicated that aeration intensity was the main factor for regulating system communities to optimize the system performance. It inferred that high aeration pressure played a key role on sewage nutrients rapid removal.

  15. Profiling and identification of the absorbed constituents and metabolites of schisandra lignans by ultra-performance liquid chromatography coupled to mass spectrometry.

    Science.gov (United States)

    Sun, Hui; Wu, Fangfang; Zhang, Aihua; Wei, Wenfeng; Han, Ying; Wang, Xijun

    2013-11-01

    Schisandra chinensis Baill grows wild in Russia, China, Korea and Japan, and its fruit has been found to be effective in amnesia and insomnia. It is enriched in schisandra lignans (SL) that are major components responsible for therapeutic action. However, there are no reports on the biotransformation analysis of SL. An ultra-performance liquid chromatography/electrospray-ionization high-definition mass spectrometry (UPLC-Q-TOF-HDMS) method was developed to investigate the metabolism of SL in vivo. MS was performed on a Waters Micromass high-definition system with an electrospray ionization source in positive ion mode and automated MetaboLynx software analysis with excellent MS accuracy and enhanced MS data acquisition. An improved mass defect filter (MDF) method employing both drug and core structure filter templates was applied to the processing of UPLC-Q-TOF-HDMS data for the detection and structural characterization of metabolites. In this study, 30 metabolites were detected and identified in vivo, and demethylation and hydroxylation were confirmed as the primacy metabolic pathway for SL in rat plasma. In conclusion, the presently developed methodology was suitable for biotransformation research of SL and will find wide use in metabolic studies for other herbal medicines.

  16. Performance outcomes of anterior cruciate ligament reconstruction in the National Basketball Association.

    Science.gov (United States)

    Busfield, Benjamin T; Kharrazi, F Daniel; Starkey, Chad; Lombardo, Stephen J; Seegmiller, Jeffrey

    2009-08-01

    The purpose of this study was to determine the rate of return to play and to quantify the effect on the basketball player's performance after surgical reconstruction of the anterior cruciate ligament (ACL). Surgical injuries involving the ACL were queried for a 10-year period (1993-1994 season through 2004-2005 season) from the database maintained by the National Basketball Association (NBA). Standard statistical categories and player efficiency rating (PER), a measure that accounts for positive and negative playing statistics, were calculated to determine the impact of the injury on player performance relative to a matched comparison group. Over the study period, 31 NBA players had 32 ACL reconstructions. Two patients were excluded because of multiple ACL injuries, one was excluded because he never participated in league play, and another was the result of nonathletic activity. Of the 27 players in the study group, 6 (22%) did not return to NBA competition. Of the 21 players (78%) who did return to play, 4 (15%) had an increase in the preinjury PER, 5 (19%) remained within 1 point of the preinjury PER, and the PER decreased by more than 1 point after return to play in 12 (44%). Although decreases occurred in most of the statistical categories for players returning from ACL surgery, the number of games played, field goal percentage, and number of turnovers per game were the only categories with a statistically significant decrease. Players in the comparison group had a statistically significant increase in the PER over their careers, whereas the study group had a marked, though not statistically significant, increase in the PER in the season after reconstruction. After ACL reconstruction in 27 basketball players, 22% did not return to a sanctioned NBA game. For those returning to play, performance decreased by more than 1 PER point in 44% of the patients, although the changes were not statistically significant relative to the comparison group. Level IV, therapeutic

  17. Distribution patterns of flavonoids from three Momordica species by ultra-high performance liquid chromatography quadrupole time of flight mass spectrometry: a metabolomic profiling approach

    CSIR Research Space (South Africa)

    Madala, NE

    2016-08-01

    Full Text Available M U F P C H I C s e c t ( t g a u p g e u 0 cRevista Brasileira de Farmacognosia 26 (2016) 507–513 ww w.elsev ier .com/ locate /b jp riginal Article istribution patterns of flavonoids from three Momordica species by ltra-high performance... i m s t 2 M P t B f o c w C t i ( ( r t s o m u Q e A q g M f f i ( a A g l t c E s a08 N.E. Madala et al. / Revista Brasileir he former two species but absent in the later. As such, the aim f the current study was to investigate the flavonoid...

  18. SUBPOPULATION PROFILES OF T HELPER CELLS EXPRESSING CD45RA AND CD31 MARKERS IN CHILDREN AFTER THYMECTOMY PERFORMED UPON SURGICAL TREATMENT OF CONGENITAL HEART DISEASE

    Directory of Open Access Journals (Sweden)

    Yu. I. Rovda

    2016-01-01

    Full Text Available Thymectomy is a stage of surgery when treating some congenital heart defects. Thymus gland is the central organ of immune system. This organ is the primary site of T-cell lymphopoiesis and central tolerance to autoantigens during fetal and early postnatal life. If performed neonatally or in infancy, the thymectomy may cause restriction of these immune functions. Suppression of T-cell lymphopoiesis in children with thymectomy can be estimated as a subpopulation of thymic naive T helper cells (CD3+CD4+CD45RA+CD31+. To perform this task, we evaluated subpopulations of thymic naive T helper lymphocytes with CD3+CD4+CD45RA+CD31+ phenotype in the children (n = 40 who underwent thymectomy during surgical treatment of congenital heart diseases in neonates, or in early postnatal life. Their data were compared with children who underwent surgical treatment of congenital heart disease without thymectomy at the same age periods (n = 12, and healthy children (n = 23. We have revealed that thymectomy in frames of surgery of congenital heart disease leads to reduced thymic naive T helper lymphocytes with CD3+CD4+CD45RA+CD31+ phenotype in peripheral blood. Early execution of thymectomy is associated with deficiency of the thymic naive T helper lymphocytes in the peripheral blood, as well as a decrease in T helper cells (CD3+CD4+. The number thymic naive T helper lymphocytes in peripheral blood negatively corrrelated with terms elapsed after the surgery of congenital heart defects in children.

  19. Plasma profiling of intact isoflavone metabolites by high-performance liquid chromatography and mass spectrometric identification of flavone glycosides daidzin and genistin in human plasma after administration of kinako.

    Science.gov (United States)

    Hosoda, Kaori; Furuta, Takashi; Yokokawa, Akitomo; Ogura, Kenichiro; Hiratsuka, Akira; Ishii, Kazuo

    2008-08-01

    The roles of isoflavones in the prevention of several hormone-dependent cancers and osteoporosis are of great interest. Despite many pharmacokinetics studies of the isoflavones, the actual types of conjugates circulating in the body and the position(s) of conjugation sites on the flavone skeleton are still uncertain because, in general, conjugated compounds in biological fluids have been evaluated by measuring the free aglycones obtained after selective enzymatic hydrolysis. Using an high-performance (HPLC)-UV-diode-array detector (DAD) method combined with solid-phase extraction, we have obtained HPLC profiles of isoflavone glycosides [daidzin (Din) and genistin (Gin)] and of intact isoflavone metabolites in human plasma: daidzein, genistein, daizein-7-glucuronide, daidzein-4'-glucuronide, genistein-7-glucuronide, genistein-4'-glucuronide, daidzein-7-sulfate, daidzein-4'-sulfate, genistein-7-sulfate, and genistein-4'-sulfate. We investigated the plasma profile of intact isoflavone metabolites in plasma obtained 1 to-7 h after orally administration of 50 g of kinako (baked soybean powder) to two healthy volunteers. The results of DAD analysis indicated that the main isoflavone metabolite peaks were identified on the HPLC chromatogram. Furthermore, the intact glycosides Din and Gin were detected in 1-h plasma samples by their positive electrospray ionization mass spectra, demonstrating that the glycosides Din and Gin can be absorbed from the gut.

  20. Validation of the concentration profiles obtained from the near infrared/multivariate curve resolution monitoring of reactions of epoxy resins using high performance liquid chromatography as a reference method.

    Science.gov (United States)

    Garrido, M; Larrechi, M S; Rius, F X

    2007-03-07

    This paper reports the validation of the results obtained by combining near infrared spectroscopy and multivariate curve resolution-alternating least squares (MCR-ALS) and using high performance liquid chromatography as a reference method, for the model reaction of phenylglycidylether (PGE) and aniline. The results are obtained as concentration profiles over the reaction time. The trueness of the proposed method has been evaluated in terms of lack of bias. The joint test for the intercept and the slope showed that there were no significant differences between the profiles calculated spectroscopically and the ones obtained experimentally by means of the chromatographic reference method at an overall level of confidence of 5%. The uncertainty of the results was estimated by using information derived from the process of assessment of trueness. Such operational aspects as the cost and availability of instrumentation and the length and cost of the analysis were evaluated. The method proposed is a good way of monitoring the reactions of epoxy resins, and it adequately shows how the species concentration varies over time.

  1. Comparative study on intestinal metabolism and absorption in vivo of ginsenosides in sulphur-fumigated and non-fumigated ginseng by ultra performance liquid chromatography quadruple time-of-flight mass spectrometry based chemical profiling approach.

    Science.gov (United States)

    Zhu, He; Shen, Hong; Xu, Jun; Xu, Jin-Di; Zhu, Ling-Ying; Wu, Jie; Chen, Hu-Biao; Li, Song-Lin

    2015-04-01

    Our previous study indicated that sulphur-fumigation of ginseng in post-harvest handling processes could induce chemical transformation of ginsenosides to generate multiple ginsenoside sulphur derivatives. In this study, the influence of sulphur-fumigation on intestinal metabolism and absorption in vivo of ginsenosides in ginseng was sequentially studied. The intestinal metabolic and absorbed profiles of ginsenosides in rats after intra-gastric (i.g.) administration of sulphur-fumigated ginseng (SFG) and non-fumigated ginseng (NFG) were comparatively characterized by a newly established ultra performance liquid chromatography quadruple time-of-flight mass spectrometry (UPLC-QTOF-MS/MS) with electrospray ionization negative (ESI-) mode. A novel strategy based on the characteristic product ions and fragmentation pathways of different types of aglycones (saponin skeletons) and glycosyl moieties was proposed and successfully applied to rapid structural identification of ginsenoside sulphur derivatives and relevant metabolites. In total, 18 ginsenoside sulphur derivatives and 26 ginsenoside sulphur derivative metabolites in the faeces together with six ginsenoside sulphur derivatives in the plasma were identified in the SFG-administrated group but not in the NFG-administrated group. The results clearly demonstrated that the intestinal metabolic and absorbed profiles of ginsenosides in sulphur-fumigated and non-fumigated ginseng were quite different, which inspired that sulphur-fumigation of ginseng should not be recommended before the bioactivity and toxicity of the ginsenoside sulphur derivatives were systematically evaluated. Copyright © 2014 John Wiley & Sons, Ltd.

  2. Expression profile of six stress-related genes and productive performances of fast and slow growing broiler strains reared under heat stress conditions

    Science.gov (United States)

    Rimoldi, Simona; Lasagna, Emiliano; Sarti, Francesca Maria; Marelli, Stefano Paolo; Cozzi, Maria Cristina; Bernardini, Giovanni; Terova, Genciana

    2015-01-01

    High temperature is one of the prominent environmental factors causing economic losses to the poultry industry as it negatively affects growth and production performance in broiler chickens. We used One Step TaqMan real time RT-PCR (reverse transcription polymerase chain reaction) technology to study the effects of chronic heat stress on the expression of genes codifying for the antioxidative enzymes superoxide dismutase (SOD), and catalase (CAT), as well as for heat shock protein (HSP) 70, HSP90, glucocorticoid receptor (NR3C1), and caspase 6 (CASP6) in the liver of two different broiler genetic strains: Red JA Cou Nu Hubbard (CN) and Ross 508 Aviagen (RO). CN is a naked neck slow growing broiler intended for the free range and/or organic markets, whereas RO is selected for fast growing. We also analysed the effect of chronic heat stress on productive performances, and plasma corticosterone levels as well as the association between transcriptomic response and specific SNPs (single nucleotide polymorphisms) in each genetic strain of broiler chickens. RO and CN broilers, 4 weeks of age, were maintained for 4 weeks at either 34 °C or 22 °C. The results demonstrated that there was a genotype and a temperature main effect on the broilers' growth from the 4th to the 8th week of age, but the interaction effect between genotype and temperature resulted not statistically significant. By considering the genotype effect, fast growing broilers (RO) grew more than the slow growing ones (CN), whereas by considering the temperature effect, broilers in unheated conditions grew more than the heat stressed ones. Corticosterone levels increased significantly in the blood of heat stressed broilers, due to the activation of the HPA (hypothalamic–pituitary–adrenocortical axis). Carcass yield at slaughter was of similar values in the 4 cohorts (genotype/temperature combinations or treatment groups), ranging from 86.5 to 88.6%, whereas carcass weight was negatively influenced

  3. Improving working memory performance in brain-injured patients using hypnotic suggestion

    DEFF Research Database (Denmark)

    Lindeløv, Jonas Kristoffer; Overgaard, Rikke; Overgaard, Morten

    2017-01-01

    be effectively restored by suggesting to hypnotized patients that they have regained their pre-injury level of working memory functioning. Following four 1-h sessions, 27 patients had a medium-sized improvement relative to 22 active controls (Bayes factors of 342 and 37.5 on the two aggregate outcome measures...... group was crossed over to the working memory suggestion and showed superior improvement. By the end of the study, both groups reached a performance level at or above the healthy population mean with standardized mean differences between 1.55 and 2.03 relative to the passive control group. We conclude...... that, if framed correctly, hypnotic suggestion can effectively improve working memory following acquired brain injury. The speed and consistency with which this improvement occurred, indicate that there may be a residual capacity for normal information processing in the injured brain....

  4. Plasma eicosanoid profiles determined by high-performance liquid chromatography coupled with tandem mass spectrometry in stimulated peripheral blood from healthy individuals and sickle cell anemia patients in treatment.

    Science.gov (United States)

    Galvão, Alyne Fávero; Petta, Tânia; Flamand, Nicolas; Bollela, Valdes Roberto; Silva, Célio Lopes; Jarduli, Luciana Ribeiro; Malmegrim, Kelen Cristina Ribeiro; Simões, Belinda Pinto; de Moraes, Luiz Alberto Beraldo; Faccioli, Lúcia Helena

    2016-05-01

    Eicosanoids play an important role in homeostasis and in the pathogenesis of various human diseases. Pharmacological agents such as Ca(2+) ionophores and Ca(2+)-ATPase inhibitors, as well as natural agonists such as formylmethionine-leucyl-phenylalanine (fMLP), can stimulate eicosanoid biosynthesis. The aims of this work were to develop a method to determine the eicosanoid profile of human plasma samples after whole blood stimulation and to assess differences between healthy and sick individuals. For this purpose, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was partially validated for the quantification of 22 eicosanoids using human plasma from healthy volunteers. In addition, we optimized a method for the stimulation of eicosanoids in human whole blood. LC-MS/MS analyses were performed by negative electrospray ionization and multiple reaction monitoring. An assumption of linearity resulted in a regression coefficient ≥0.98 for all eicosanoids tested. The mean intra-assay and inter-assay accuracy and precision values had relative standard deviations and relative errors of ≤15%, except for the lower limit of quantification, where these values were ≤20%. For whole blood stimulation, four stimuli (fMLP, ionomycin, A23187, and thapsigargin) were tested. Results of the statistical analysis showed that A23187 and thapsigargin were potent stimuli for the production or liberation of eicosanoids. We next compared the eicosanoid profiles of stimulated whole blood samples of healthy volunteers to those of patients with sickle cell anemia (SCA) under treatment with hydroxyurea (HU) or after chronic red blood cell (RBC) transfusion. The results indicate that the method was sufficient to find a difference between lipid mediators released in whole blood of SCA patients and those of healthy subjects, mainly for 5-HETE, 12-HETE, LTB4, LTE4, TXB2, and PGE2. In conclusion, our analytical method can detect significant changes in eicosanoid profiles in

  5. Comprehensive profiling of mercapturic acid metabolites from dietary acrylamide as short-term exposure biomarkers for evaluation of toxicokinetics in rats and daily internal exposure in humans using isotope dilution ultra-high performance liquid chromatography tandem mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yu [Department of Food Science and Nutrition, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, Zhejiang (China); Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang R & D Center for Food Technology and Equipment, Fuli Institute of Food Science, Zhejiang University, Hangzhou 310058, Zhejiang (China); Wang, Qiao; Cheng, Jun [Department of Food Science and Nutrition, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, Zhejiang (China); Zhang, Jingshun; Xu, Jiaojiao [Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, Zhejiang (China); Ren, Yiping, E-mail: renyiping@263.net [Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, Zhejiang (China)

    2015-09-24

    Mercapturic acid metabolites from dietary acrylamide are important short-term exposure biomarkers for evaluating the in vivo toxicity of acrylamide. Most of studies have focused on the measurement of two metabolites, N-acetyl-S-(2-carbamoylethyl)-L-cysteine (AAMA) and N-acetyl-S-(2-carbamoyl-2-hydroxyethyl)-L-cysteine (GAMA). Thus, the comprehensive profile of acrylamide urinary metabolites cannot be fully understood. We developed an isotope dilution ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method for the simultaneous determination of all four mercapturic acid adducts of acrylamide and its primary metabolite glycidamide under the electroscopy ionization negative (ESI-) mode in the present study. The limit of detection (LOD) and limit of quantification (LOQ) of the analytes ranged 0.1–0.3 ng/mL and 0.4–1.0 ng/mL, respectively. The recovery rates with low, intermediate and high spiking levels were calculated as 95.5%–105.4%, 98.2%–114.0% and 92.2%–108.9%, respectively. Acceptable within-laboratory reproducibility (RSD < 7.0%) substantially supported the use of current method for robust analysis. Rapid pretreatment procedures and short run time (8 min per sample) ensured good efficiency of metabolism profiling, indicating a wide application for investigating short-term internal exposure of dietary acrylamide. Our proposed UHPLC-MS/MS method was successfully applied to the toxicokinetic study of acrylamide in rats. Meanwhile, results of human urine analysis indicated that the levels of N-acetyl-S-(2-carbamoylethyl)-L-cysteine-sulfoxide (AAMA-sul), which did not appear in the mercapturic acid metabolites in rodents, were more than the sum of GAMA and N-acetyl-S-(1-carbamoyl-2-hydroxyethyl)-L-cysteine (iso-GAMA). Thus, AAMA-sul may alternatively become a specific biomarker for investigating the acrylamide exposure in humans. Current proposed method provides a substantial methodology support for comprehensive

  6. Metabolic profiles of physalin A in rats using ultra-high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry.

    Science.gov (United States)

    Feng, Xinchi; Liu, Hongxia; Chai, Liwei; Ding, Liqin; Pan, Guixiang; Qiu, Feng

    2017-03-01

    Physalin A, one of the major active components isolated from the calyces of Physalis alkekengi var. franchetii is considered to be a promising natural product due to its anti-inflammatory and excellent antitumor activities. Until now, only one paper is available from our group concerning identification of two sulfonate metabolites from rat feces after physalin A treatment. All the other researches related to physalin A were focused on its extraction, separation and biological activities. In this research, a rapid and reliable ultra-high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF-MS/MS) method was developed and employed for the comprehensive study of the metabolism of physalin A in vivo for the first time. A total of 24 proposed metabolites were identified in plasma, bile, urine and feces of rats after oral administration of physalin A. The results indicated that sulfonation, reduction and hydroxylation were the major metabolic pathways of physalin A in vivo. Furthermore, this research provides scientific and reliable support for full understanding of the metabolism of physalin A and the results could help to elucidate the safety and efficacy of physalin A, as well as other physalins.

  7. Ultra-performance liquid chromatography-tandem mass spectrometry determination and depletion profile of flunixin residues in tissues after single oral administration in rabbits.

    Science.gov (United States)

    Zhu, Ai-Ling; Peng, Tao; Liu, Liang; Xia, Xi; Hu, Ting; Tao, Xiao-Qi; Wen, Kai; Cheng, Lin-Li; Li, Jian-Cheng; Ding, Shuang-Yang; Cao, Xing-Yuan; Jiang, Hai-Yang

    2013-09-01

    An ultra-performance liquid chromatography with tandem mass spectrometric detection (UPLC-MS/MS) method was developed for the detection of flunixin residues in rabbit tissues. The samples were extracted with acidic acetonitrile, defatted with n-hexane, and then purified by HLB solid-phase extraction cartridge. Analysis was carried out on UPLC-ESI-MS/MS working with multiple reaction monitoring (MRM) mode. The limits of detection (LODs) of the method were 0.3-0.8μgkg(-1) and limits of quantification (LOQs) were 1.0-3.0μgkg(-1) in rabbit tissues, respectively. In all fortified samples at a concentration range of 1.0-300.0μgkg(-1), mean recoveries were 61.7-115.7% with relative standard deviations (RSDs) below 16%. Residue depletion of flunixin in rabbit was conducted after oral administration at a dose of 5mgkg(-1) of body weight. The average concentrations for flunixin measured 2h post-administration in kidney and intestine were significantly higher than in liver, heart and muscle. The concentrations for flunixin in all rabbit tissues were below the LOD or not detected in all tissues after 96h administration of drug. A minimum withdrawal time of 21h was indicated for residue levels in heart, liver, kidney, intestine and muscle below the maximum residue limits (MRLs).

  8. Biotransformation and metabolic profile of catalpol with human intestinal microflora by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.

    Science.gov (United States)

    Tao, Jin-hua; Zhao, Min; Wang, Dong-geng; Yang, Chi; Du, Le-Yue; Qiu, Wen-qian; Jiang, Shu

    2016-01-15

    Traditional Chinese medicine (TCM) has been used in clinical practice for thousands of years. Catalpol, an iridoid glucoside, abundantly found in the root of the common used herb medicine Rehmannia glutinosa Libosch, has been reported to show various biological effects and pharmacological activities. After oral administration, the active ingredient might have interactions with the intestinal bacteria, which could help unravel how the medicine was processed in vivo. In this work, different pure bacteria from healthy human feces were isolated and used to bioconvert catalpol. Ultra performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF/MS) technique combined with Metabolynx(™) software was applied to analyze catalpol metabolites. Compared with blank samples, parent compound (M0) and four metabolites (M1-M4) were detected and tentatively identified based on the characteristics of their protonated ions. The metabolites were likely to be: catalpol aglycone (M1), acetylated catalpol (M2), dimethylated and hydroxylated catalpol aglycone (M3), nitrogen-containing catalpol aglycone (M4). M1 and M4 were generated in the majority of the samples like Bacteroides sp. 45. M3 was obtained in several bacterial samples like Enterococcus sp. 8-2 and M2 was detected only in the sample of Enterococcus sp. 43-1. To our knowledge, the metabolic routes and metabolites of catalpol produced by human intestinal bacteria were all firstly reported.

  9. Distribution patterns of flavonoids from three Momordica species by ultra-high performance liquid chromatography quadrupole time of flight mass spectrometry: a metabolomic profiling approach

    Directory of Open Access Journals (Sweden)

    Ntakadzeni Edwin Madala

    Full Text Available ABSTRACT Plants from the Momordica genus, Curcubitaceae, are used for several purposes, especially for their nutritional and medicinal properties. Commonly known as bitter gourds, melon and cucumber, these plants are characterized by a bitter taste owing to the large content of cucurbitacin compounds. However, several reports have shown an undisputed correlation between the therapeutic activities and polyphenolic flavonoid content. Using ultra-high performance liquid chromatography quadrupole time of flight mass spectrometry in combination with multivariate data models such as principal component analysis and hierarchical cluster analysis, three Momordica species (M. foetida Schumach., M. charantia L. and M. balsamina L. were chemo-taxonomically grouped based on their flavonoid content. Using a conventional mass spectrometric-based approach, thirteen flavonoids were tentatively identified and the three species were found to contain different isomers of the quercetin-, kaempferol- and isorhamnetin-O-glycosides. Our results indicate that Momordica species are overall very rich sources of flavonoids but do contain different forms thereof. Furthermore, to the best of our knowledge, this is a first report on the flavonoid content of M. balsamina L.

  10. Ultra performance liquid chromatography-tandem quadrupole mass spectrometry profiling of anthocyanins and flavonols in cowpea (Vigna unguiculata) of varying genotypes.

    Science.gov (United States)

    Ojwang, Leonnard O; Dykes, Linda; Awika, Joseph M

    2012-04-11

    The structure of flavonoids in food plants affects bioactivity and important nutritional attributes, like micronutrient bioavailability. This study investigated flavonol and anthocyanin compositions of cowpea (Vigna unguiculata) of varying genotypes. Black, red, green, white, light brown, and golden brown cowpea phenotypes were analyzed for anthocyanins and flavonols using ultra performance liquid chromatography-tandem quadrupole mass spectrometry. Eight anthocyanins and 23 flavonols (15 newly identified in cowpea) were characterized. Mono-, di-, and tri(acyl)glycosides of quercetin were predominant in most phenotypes; myricetin and kaempferol glycosides were present only in specific phenotypes. The red phenotypes had the highest flavonol content (880-1060 μg/g), whereas green and white phenotypes had the lowest (270-350 μg/g). Only black (1676-2094 μg/g) and green (875 μg/g) phenotypes had anthocyanins, predominantly delphinidin and cyanidin 3-O-glucosides. Cowpea phenotype influenced the type and amount of flavonoids accumulated in the seed; this may have implications in selecting varieties for nutrition and health applications.

  11. Metabolite Profile of Salidroside in Rats by Ultraperformance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry and High-Performance Liquid Chromatography Coupled with Quadrupole-Linear Ion Trap Mass Spectrometry.

    Science.gov (United States)

    Hu, Zhiwei; Wang, Ziming; Liu, Yong; Wu, Yan; Han, Xuejiao; Zheng, Jian; Yan, Xiufeng; Wang, Yang

    2015-10-21

    In the present work, the salidroside metabolite profile in rat urine was investigated, and subsequently the metabolic pathways of salidroside were proposed. After administrations of salidroside at an oral dose of 100 or 500 mg/kg, rat urine samples were collected and pretreated with methanol to precipitate the proteins. The pretreated samples were analyzed by an Acquity ultraperformance liquid chromatography (UPLC) coupled with an HSS T3 column and detected by quadrupole time-of-flight mass spectrometry (Q-TOF-MS) or high-performance liquid chromatography coupled with hybrid triple-quadrupole linear ion trap mass spectrometry (HPLC/Q-trap-MS). A total of eight metabolites were detected and identified on the basis of the characteristics of their protonated ions in the urine samples. The results elucidated that salidroside was metabolized via glucuronidation, sulfation, deglycosylation, hydroxylation, methylation, and dehydroxylation pathways in vivo.

  12. Identity-based High-performance thin Layer Chromatography Fingerprinting Profile and Tumor Inhibitory Potential of Anisochilus carnosus (L.f.) wall Against Ehrlich Ascites Carcinoma

    Science.gov (United States)

    Gupta, Nilesh; Lobo, Richard; Kumar, Nimmy; Bhagat, Jay Kumar; Mathew, Jessy Elizabeth

    2015-01-01

    Context: Anisochilus carnosus (L.f.) wall belonging to the family Lamiaceae is a plant that is widely used in folk medicine for treating eczema, cold, cough, and fever. Objective: In the present study, we explored the anticancer potential of A. carnosus leaves against Ehrlich ascites carcinoma (EAC) and estimated the quantity of luteolin present in various extracts and fractions of A. carnosus by high-performance thin layer chromatography (HPTLC) fingerprinting. Materials and Methods: Various factors such as tumor volume, tumor cell viability, tumor weight, prolongation of lifespan, and hematological parameters were assessed. Result: We observed a significant lowering in tumor volume, tumor weight, and cell viability in EAC-induced mice following intervention with A. carnosus extracts. Also, there was a considerable prolongation of host lifespan and restoration of hematological parameters to almost normal levels with A. carnosus treatment. HPTLC fingerprinting of various extracts and fractions of A. carnosus along with luteolin as the reference standard revealed the occurrence of luteolin in all tested extracts and fractions of A. carnosus with the highest concentration being reported in the ethanol fraction. Conclusion: A. carnosus exhibits potent anti-tumor potential which can most likely be attributed to the occurrence of different phytochemicals such as phytosterols, terpenoids, and flavonoids in the plant. Further studies to isolate compounds from A. carnosus and understand the mechanism of anti-tumor activity would be worthwhile. SUMMARY EAC induced mice that received A. carnosus treatment exhibited significant reduction in tumor volume, tumor weight and tumor cell viability. Their life span was considerably prolonged. We detected luteolin in A. carnosus aqueous and ethanol extract using HPTLC. Hence, anticancer activity of A. carnosus can be partly attributed to the presence of luteolin. PMID:26929584

  13. Integrated comparison of drug-related and drug-induced ultra performance liquid chromatography/mass spectrometry metabonomic profiles using human hepatocyte cultures.

    Science.gov (United States)

    Croixmarie, Vincent; Umbdenstock, Thierry; Cloarec, Olivier; Moreau, Amélie; Pascussi, Jean-Marc; Boursier-Neyret, Claire; Walther, Bernard

    2009-08-01

    The biochemical variations induced in human primary hepatocyte cultures by reference activators of xenoreceptor CAR (NR1I3) and PXR (NR1I2), i.e., rifampicin, phenobarbital, and 6-(4-chlorophenyl)imidazo[2,1-b] [1,3]thiazole-5-carbaldehyde O-3,4-dichlorobenzyl) oxime (CITCO), were investigated using a global metabonomics approach. Cultured human hepatocytes were treated with the three drugs before analysis of intracellular and extracellular media by ultra performance liquid chromatography/time-of-flight-mass spectrometry (UPLC/TOF-MS) technique, in order to list endogenous compounds potentially related to a PXR or CAR induction mechanism and to identify drug metabolites related to each treatment. The emphasis was put on the quality of the analytical data (dilution/filtration strategy before data processing) and on the appropriate pattern recognition techniques. In cellular media, the most significant variations seen in the data are not related to the treatments but to the source of hepatocytes, illustrating the importance of the genetic and/or environmental background in human liver experiments. However when applying classical multivariate statistical approaches (principal component analysis (PCA) and orthogonal partial least squares (O-PLS)), the statistical weight due to drug metabolites, present only in the treated groups, hinders the interpretation because of their predominance compared to most of the changes seen in endogenous metabolites. A new statistical approach, called shared and unique structure (SUS) plot, enabling the comparison of different treatments having the same control has been applied, allowing separation of clearly exogenous variables (drug metabolites) from endogenous biomarkers. Endogenous variables (either up- or down-regulated) have been attributed specifically to the impact of rifampicin (PXR ligand), CITCO (CAR ligand), and phenobarbital (CAR and PXR activator) on the biological regulation pathways of the hepatocytes. This global

  14. Effects of dietary Lactobacillus plantarum B1 on growth performance, intestinal microbiota, and short chain fatty acid profiles in broiler chickens.

    Science.gov (United States)

    Peng, Q; Zeng, X F; Zhu, J L; Wang, S; Liu, X T; Hou, C L; Thacker, P A; Qiao, S Y

    2016-04-01

    Two experiments were conducted to determine the effects of Lactobacillus plantarum B1 on broiler performance, cecal bacteria, and ileal and cecal short chain fatty acids (SCFA). The study also determined whether it was necessary to feed Lactobacillus throughout the entire growth period or if the beneficial effects could be obtained by supplementation during the starter or finisher period only. Experiment 1 was conducted with 72 broilers assigned to 2 treatments (N=6). One treatment was the basal diet (Con), and the other was the basal diet supplemented with 2×10(9) cfu/kg L. plantarum B1 (Wh). In experiment 2, 144 one-day-old broilers were assigned to 4 treatments (N=6) including a basal diet (Con), the basal diet supplemented with 2×10(9) cfu/kgL. plantarum B1 during d one to 21 only (St), the basal diet supplemented with L. plantarum B1 during d 22 to 42 only (Fn), and, finally, the basal diet supplemented with L. plantarum B1 from d one to 42 (Wh). Experiment 1 showed that L. plantarum B1 enhanced broiler average daily gain (ADG) and feed conversion ratio (FCR). In experiment 2, during the starter period, broilers in the Wh and St treatments had higher ADG (Pplantarum B1 also increased (Pplantarum B1 had no effect on intestinal morphology. In conclusion,L. plantarum B1 plays a positive role in broilers. Supplementation during the finisher period or the entire growth period is superior to supplementation during the starter period only.

  15. Comprehensive Benchmark Suite for Simulation of Particle Laden Flows Using the Discrete Element Method with Performance Profiles from the Multiphase Flow with Interface eXchanges (MFiX) Code

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Peiyuan [Univ. of Colorado, Boulder, CO (United States); Brown, Timothy [Univ. of Colorado, Boulder, CO (United States); Fullmer, William D. [Univ. of Colorado, Boulder, CO (United States); Hauser, Thomas [Univ. of Colorado, Boulder, CO (United States); Hrenya, Christine [Univ. of Colorado, Boulder, CO (United States); Grout, Ray [National Renewable Energy Lab. (NREL), Golden, CO (United States); Sitaraman, Hariswaran [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-01-29

    Five benchmark problems are developed and simulated with the computational fluid dynamics and discrete element model code MFiX. The benchmark problems span dilute and dense regimes, consider statistically homogeneous and inhomogeneous (both clusters and bubbles) particle concentrations and a range of particle and fluid dynamic computational loads. Several variations of the benchmark problems are also discussed to extend the computational phase space to cover granular (particles only), bidisperse and heat transfer cases. A weak scaling analysis is performed for each benchmark problem and, in most cases, the scalability of the code appears reasonable up to approx. 103 cores. Profiling of the benchmark problems indicate that the most substantial computational time is being spent on particle-particle force calculations, drag force calculations and interpolating between discrete particle and continuum fields. Hardware performance analysis was also carried out showing significant Level 2 cache miss ratios and a rather low degree of vectorization. These results are intended to serve as a baseline for future developments to the code as well as a preliminary indicator of where to best focus performance optimizations.

  16. Oral administration of amino acidic supplements improves protein and energy profiles in skeletal muscle of aged rats: elongation of functional performance and acceleration of mitochondrial recovery in adenosine triphosphate after exhaustive exertion.

    Science.gov (United States)

    Chen Scarabelli, Carol; McCauley, Roy B; Yuan, Zhaokan; Di Rezze, Justin; Patel, David; Putt, Jeff; Raddino, Riccardo; Allebban, Zuhair; Abboud, John; Scarabelli, Gabriele M; Chilukuri, Karuna; Gardin, Julius; Saravolatz, Louis; Faggian, Giuseppe; Mazzucco, Alessandro; Scarabelli, Tiziano M

    2008-06-02

    Sarcopenia is an inevitable age-related degenerative process chiefly characterized by decreased synthesis of muscle proteins and impaired mitochondrial function, leading to progressive loss of muscle mass. Here, we sought to probe whether long-term administration of oral amino acids (AAs) can increase protein and adenosine triphosphate (ATP) content in the gastrocnemius muscle of aged rats, enhancing functional performance. To this end, 6- and 24-month-old male Fisher 344 rats were divided into 3 groups: group A (6-month-old rats) and group B (24-month-old rats) were used as adult and senescent control group, respectively, while group C (24-month-old rats) was used as senescent treated group and underwent 1-month oral treatment with a mixture of mainly essential AAs. Untreated senescent animals exhibited a 30% reduction in total and fractional protein content, as well as a 50% reduction in ATP content and production, compared with adult control rats (p supplementation with mixed AAs significantly improved protein and high-energy phosphate content, as well as the rate of mitochondrial ATP production, conforming their values to those of adult control animals (p energy substrates in the gastrocnemius muscle of treated aged rats paralleled a significant enhancement in functional performance assessed by swim test, with dramatic elongation of maximal exertion times compared with untreated senescent rats (p supplementation with oral AAs improved protein and energy profiles in the gastrocnemius of treated rats, enhancing functional performance and accelerating high-energy phosphate recovery after exhaustive exertion.

  17. Effects of feeding extruded full-fat cottonseed pellets in place of tallow as a fat source for finishing heifers on feedlot performance, carcass characteristics, sensory traits, display color, and fatty acid profiles.

    Science.gov (United States)

    Stelzleni, A M; Froetschel, M A; Pringle, T D

    2013-09-01

    The objective of this study was to examine the effects of supplemental feeding of full-fat extruded cottonseed pellets (FFECS) compared with tallow on carcass characteristics, sensory traits, retail display color, and fatty acid profiles, especially CLA isomers in finishing heifers. Twenty-one Angus heifers (450 ± 5 kg) were assigned randomly to 1 of 3 experimental diets: 1) 100% supplemental fat from tallow at 4.1% of ration DM (TAL), 2) a 50:50 ratio of supplemental fat from a combination of tallow at 2.1% and FFECS at 12.8% of ration DM (TAL/ECS), and 3) 100% supplemental fat from FFECS at 25.6% ration DM (ECS). All rations were formulated to contain 7.5% fat on a DM basis. Heifers were individually fed, ad libitum, for 82 d, and BW, G:F, DMI, ADG, and body composition via ultrasound were collected at 3 to 4 wk intervals. After 82 d on feed heifers were slaughtered under federal inspection, and carcass characteristics were measured (at 24 h). The LM was removed for retail display color (1, 3, 6, 10 d), Warner-Bratzler shear force (1, 3, 7, 14, 21 d postmortem aging), sensory analysis (1, 7, 14, 21 d postmortem aging), and fatty acid profile analysis. Subcutaneous fat, including all layers, was removed from the LM for fatty acid profile analysis, and ground beef patties (80:20) were produced with lean from the brisket and fat from the plate for retail color analysis (1, 2, 4, 7 d). Supplemental fat source did not influence feedlot performance for any of the traits measured (P > 0.12) or any carcass traits related to yield, quality, or LM color at the 12th- to 13th-rib interface (P > 0.15). Supplemental fat source did not affect Warner-Bratzler shear force or any sensory traits (P > 0.20), but LM steaks became more tender as postmortem aging time increased up to 14 d (P tallow increased linoleic acid (C18:2(n-6)) in both intramuscular and subcutaneous fat (P 0.90). Full-fat extruded cottonseed pellets are interchangeable with tallow in heifer finishing diets

  18. Advanced Multiple Aperture Seeing Profiler

    Science.gov (United States)

    Ren, Deqing; Zhao, Gang

    2016-10-01

    Measurements of the seeing profile of the atmospheric turbulence as a function of altitude are crucial for solar astronomical site characterization, as well as the optimized design and performance estimation of solar Multi-Conjugate Adaptive Optics (MCAO). Knowledge of the seeing distribution, up to 30 km, with a potential new solar observation site, is required for future solar MCAO developments. Current optical seeing profile measurement techniques are limited by the need to use a large facility solar telescope for such seeing profile measurements, which is a serious limitation on characterizing a site's seeing conditions in terms of the seeing profile. Based on our previous work, we propose a compact solar seeing profiler called the Advanced Multiple Aperture Seeing Profile (A-MASP). A-MASP consists of two small telescopes, each with a 100 mm aperture. The two small telescopes can be installed on a commercial computerized tripod to track solar granule structures for seeing profile measurement. A-MASP is extreme simple and portable, which makes it an ideal system to bring to a potential new site for seeing profile measurements.

  19. Plasma Metabolic Profile Determination in Young ST-segment Elevation Myocardial Infarction Patients with Ischemia and Reperfusion: Ultra-performance Liquid Chromatography and Mass Spectrometry for Pathway Analysis

    Institute of Scientific and Technical Information of China (English)

    Lei Huang; Tong Li; Ying-Wu Liu; Lei Zhang; Zhi-Huan Dong; Shu-Ye Liu; Ying-Tang Gao

    2016-01-01

    Background:This study was to establish a disease differentiation model for ST-segment elevation myocardial infarction (STEMI) youth patients experiencing ischemia and reperfusion via ultra-performance liquid chromatography and mass spectrometry (UPLC/MS) platform,which searches for closely related characteristic metabolites and metabolic pathways to evaluate their predictive value in the prognosis after discharge.Methods:Forty-seven consecutive STEMI patients (23 patients under 45 years of age,referred to here as "youth," and 24 "elderly" patients) and 48 healthy control group members (24 youth,24 elderly) were registered prospectively.The youth patients were required to provide a second blood draw during a follow-up visit one year after morbidity (n =22,one lost).Characteristic metabolites and relative metabolic pathways were screened via UPLC/MS platform base on the Kyoto encyclopedia of genes and genomes (KEGG) and Human Metabolome Database.Receiver operating characteristic (ROC) curves were drawn to evaluate the predictive value of characteristic metabolites in the prognosis after discharge.Results:We successfully established an orthogonal partial least squares discriminated analysis model (R2X =71.2%,R2Y =79.6%,and Q2 =55.9%) and screened out 24 ions; the sphingolipid metabolism pathway showed the most drastic change.The ROC curve analysis showed that ceramide [Cer(d18:0/16:0),Cer(t18:0/12:0)] and sphinganine in the sphingolipid pathway have high sensitivity and specificity on the prognosis related to major adverse cardiovascular events after youth patients were discharged.The area under curve (AUC) was 0.671,0.750,and 0.711,respectively.A follow-up validation one year after morbidity showed corresponding AUC of 0.778,0.833,and 0.806.Conclusions:By analyzing the plasma metabolism of myocardial infarction patients,we successfully established a model that can distinguish two different factors simultaneously:pathological conditions and age

  20. Peptide profiling of Internet-obtained Cerebrolysin using high performance liquid chromatography - electrospray ionization ion trap and ultra high performance liquid chromatography - ion mobility - quadrupole time of flight mass spectrometry.

    Science.gov (United States)

    Gevaert, Bert; D'Hondt, Matthias; Bracke, Nathalie; Yao, Han; Wynendaele, Evelien; Vissers, Johannes Petrus Cornelis; De Cecco, Martin; Claereboudt, Jan; De Spiegeleer, Bart

    2015-09-01

    Cerebrolysin, a parenteral peptide preparation produced by controlled digestion of porcine brain proteins, is an approved nootropic medicine in some countries. However, it is also easily and globally available on the Internet. Nevertheless, until now, its exact chemical composition was unknown. Using high performance liquid chromatography (HPLC) coupled to ion trap and ultra high performance liquid chromatography (UHPLC) coupled to quadrupole-ion mobility-time-of-flight mass spectrometry (Q-IM-TOF MS), combined with UniProt pig protein database search and PEAKS de novo sequencing, we identified 638 unique peptides in an Internet-obtained Cerebrolysin sample. The main components in this sample originate from tubulin alpha- and beta-chain, actin, and myelin basic protein. No fragments of known neurotrophic factors like glial cell-derived neurotrophic factor (GDNF), neurotrophin nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and ciliary neurotrophic factor (CNTF) were found, suggesting that the activities reported in the literature are likely the result of new, hitherto unknown cryptic peptides with nootropic properties.

  1. Effects of Saccharomyces cerevisiae cell wall extract and poplar propolis ethanol extract supplementation on growth performance, digestibility, blood profile, fecal microbiota and fecal noxious gas emissions in growing pigs.

    Science.gov (United States)

    Li, Jian; Kim, In H

    2014-06-01

    A total of 105 growing pigs (24.91 ± 1.06 kg) were used in a 6-week trial to investigate the effects of including Saccharomyces cerevisiae cell wall extract and poplar propolis ethanol extract (SPE) in the diet on growth performance, digestibility, blood profiles, fecal microbiota and fecal noxious gas emissions. Pigs were randomly allocated to one of three dietary treatments (seven pens/treatment, five pigs/pen) according to initial body weight and sex (two gilts and three barrows). Treatments consisted of a corn soybean meal basal diet supplemented with 0, 0.05 or 0.10% SPE. There was a significant linear improvement (P red blood cells and white blood cells concentration were not significantly (P > 0.05) affected by SPE supplementation in the diets. In conclusion, results indicate that dietary SPE supplementation can improve growth performance, digestibility and fecal microbiota, and decrease fecal gas emissions in growing pigs. © 2014 Japanese Society of Animal Science.

  2. Effects of replacing palm oil with maize oil and Curcuma longa supplementation on the performance, carcass characteristics, meat quality and fatty acid profile of the perirenal fat and muscle of growing rabbits.

    Science.gov (United States)

    Peiretti, P G; Masoero, G; Meineri, G

    2011-04-01

    An experiment has been conducted to study the effects of the inclusion of plant oil in rabbit diets. This study was aimed at evaluating the beneficial effects of the inclusion of maize oil (MO), rich in unsaturated fatty acids (UFAs), compared to palm oil (PO) containing saturated fatty acids (SFAs), on the meat fatty acid (FA) profile. As UFAs are susceptible to rancidity, Curcuma longa (CL), which is known for its antioxidant properties, was also added (3 g/kg) to the diet with two plant oils. CL contains curcuminoids, volatile oils, sugars, proteins, resins and polyunsaturated fatty acids (PUFAs). We also evaluated the influence of CL inclusion in the diet on the FA profile of the meat. Furthermore, the possibility of using these oil-enriched diets and the ability to assimilate CL in rabbits was evaluated by analysing the performance, carcass characteristics and meat quality. At the end of the experiment, there were no significant differences between the groups concerning the live weight, live weight gain, feed consumption, feed efficiency, carcass yield or the percentages of edible organs. The hind legs, forelegs, loins and abdominal wall, breast and ribs, skin and limbs and head were not affected by the oil type or by the inclusion of CL. The chemical composition, pH and oxidative status of the Longissimus dorsi muscle of the rabbits fed the experimental diets were not affected by the oil source or by the CL supplementation. Conversely, it has been shown that it is possible to modify the FA profile of rabbit meat and fat by dietary means. The SFA/PUFA ratio significantly decreased from -18% to -16% in the meat and from -25% to -23% in the perirenal fat of the rabbits fed diets containing MO without or with CL supplementation, respectively, compared to same tissues of the rabbits fed diets containing PO without or with CL supplementation, respectively. Similar trends were found for the atherogenic index, which decreased from -20% to -17% in the meat and from

  3. Reversed-phase ultra-high-performance liquid chromatography coupled to electrospray ionization-quadrupole-time-of-flight mass spectrometry as a powerful tool for metabolic profiling of vegetables: Lactuca sativa as an example of its application.

    Science.gov (United States)

    Abu-Reidah, I M; Contreras, M M; Arráez-Román, D; Segura-Carretero, A; Fernández-Gutiérrez, A

    2013-10-25

    Lettuce (Lactuca sativa), a leafy vegetal widely consumed worldwide, fresh cut or minimally processed, constitutes a major dietary source of natural antioxidants and bioactive compounds. In this study, reversed-phase ultra-high-performance liquid chromatography (RP-UHPLC) coupled to electrospray ionization-quadrupole-time-of-flight mass spectrometry (ESI-QTOF-MS) was applied for the comprehensive profiling of polar and semi-polar metabolites from three lettuce cultivars (baby, romaine, and iceberg). The UHPLC systems allowed the use of a small-particle-size C18 column (1.8 μm), with very fine resolution for the separation of up to seven isomers, and the QTOF mass analyzer enabled sensitive detection with high mass resolution and accuracy in full scan. Thus, a total of 171 compounds were tentatively identified by matching their accurate mass signals and suggested molecular formula with those previously reported in family Asteraceae. Afterwards, their structures were also corroborated by the MS/MS data provided by the QTOF analyzer. Well-known amino acids, organic acids, sesquiterpene lactones, phenolic acids and flavonoids were characterized, e.g. lactucin, lactucopicrin, caftaric acid, chlorogenic acid, caffeoylmalic acid, chicoric acid, isochlorogenic acid A, luteolin, and quercetin glycosides. For this plant species, this is the first available report of several isomeric forms of the latter polyphenols and other types of components such as nucleosides, peptides, and tryptophan-derived alkaloids. Remarkably, 10 novel structures formed by the conjugation of known amino acids and sesquiterpene lactones were also proposed. Thus, the methodology applied is a useful option to develop an exhaustive metabolic profiling of plants that helps to explain their potential biological activities and folk uses.

  4. Comprehensive profiling of mercapturic acid metabolites from dietary acrylamide as short-term exposure biomarkers for evaluation of toxicokinetics in rats and daily internal exposure in humans using isotope dilution ultra-high performance liquid chromatography tandem mass spectrometry.

    Science.gov (United States)

    Zhang, Yu; Wang, Qiao; Cheng, Jun; Zhang, Jingshun; Xu, Jiaojiao; Ren, Yiping

    2015-09-24

    Mercapturic acid metabolites from dietary acrylamide are important short-term exposure biomarkers for evaluating the in vivo toxicity of acrylamide. Most of studies have focused on the measurement of two metabolites, N-acetyl-S-(2-carbamoylethyl)-L-cysteine (AAMA) and N-acetyl-S-(2-carbamoyl-2-hydroxyethyl)-L-cysteine (GAMA). Thus, the comprehensive profile of acrylamide urinary metabolites cannot be fully understood. We developed an isotope dilution ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method for the simultaneous determination of all four mercapturic acid adducts of acrylamide and its primary metabolite glycidamide under the electroscopy ionization negative (ESI-) mode in the present study. The limit of detection (LOD) and limit of quantification (LOQ) of the analytes ranged 0.1-0.3 ng/mL and 0.4-1.0 ng/mL, respectively. The recovery rates with low, intermediate and high spiking levels were calculated as 95.5%-105.4%, 98.2%-114.0% and 92.2%-108.9%, respectively. Acceptable within-laboratory reproducibility (RSDrats. Meanwhile, results of human urine analysis indicated that the levels of N-acetyl-S-(2-carbamoylethyl)-L-cysteine-sulfoxide (AAMA-sul), which did not appear in the mercapturic acid metabolites in rodents, were more than the sum of GAMA and N-acetyl-S-(1-carbamoyl-2-hydroxyethyl)-L-cysteine (iso-GAMA). Thus, AAMA-sul may alternatively become a specific biomarker for investigating the acrylamide exposure in humans. Current proposed method provides a substantial methodology support for comprehensive profiling of toxicokinetics and daily internal exposure evaluations of acrylamide in vivo.

  5. Performance profiles of major energy producers 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-01-01

    This publication examines developments in the operations of the major US e energy-producing companies on a corporate level, by major line of business, by major function within each line of business, and by geographic area. In 1996, 24 companies filed Form EIA-28. The analysis and data presented in this report represents the operations of the Financial Reporting System companies in the context of their worldwide operations and in the context of the major energy markets which they serve. Both energy and nonenergy developments of these companies are analyzed. Although the focus is on developments in 1996, important trends prior to that time are also featured. Sections address energy markets in 1996; key financial developments; oil and gas exploration, development, and production; downstream petroleum in 1996; coal and alternative energy; and foreign direct investment in US energy. 30 figs., 104 tabs.

  6. Porphyrins profile by high performance liquid chromatography ...

    African Journals Online (AJOL)

    E. Fateen

    2008-09-07

    Sep 7, 2008 ... b Biochemistry Department, Faculty of Pharmacy, Cairo University, Egypt c Pediatric ... thesis. The rate is limited by iron availability and is not inhib- ited by haem [3] ... cal genetics department's clinic, National Research Centre.

  7. Profiling Exiting Postgraduate Students' Performance and Experiences

    Science.gov (United States)

    Albertyn, R. M.; Kapp, C. A.; Bitzer, E. M.

    2008-01-01

    Transitions in an era of globalisation and universal change impact on postgraduate training of students at higher education institutions. This study aimed to determine completion rates for postgraduate programmes in Education at one higher education institution, to identify the students' needs and to investigate their experiences of postgraduate…

  8. COMPENDEX Profiling Guide.

    Science.gov (United States)

    Standera, Oldrich

    This manual provides instructions for completing the COMPENDEX (Computerized Engineering Index) Profile Submission Form used to prepare Current Information Selection (CIS) profiles. An annotated bibliography lists nine items useful in searching for proper profile words. (AB)

  9. DEVELOPMENT OF BODY COMPOSITION, HORMONE PROFILE, PHYSICAL FITNESS, GENERAL PERCEPTUAL MOTOR SKILLS, SOCCER SKILLS AND ON-THE-BALL PERFORMANCE IN SOCCER-SPECIFIC LABORATORY TEST AMONG ADOLESCENT SOCCER PLAYERS

    Directory of Open Access Journals (Sweden)

    Tomi Vänttinen

    2010-12-01

    Full Text Available The aim of the present study was to examine the development of on-the-ball skills in soccer-specific laboratory test and to examine how traditional measures of body composition, hormone profile, physical fitness, general perceptual motor skills and soccer skills were related to performance measured in open skill environment among 10, 12, and 14-year-old regional male soccer players (n = 12/group. The measured variables were height, weight, fat, muscle mass, testosterone, 10m sprint, agility, counter movement jump, peripheral awareness, Eye- Hand-Foot coordination, passing skill, dribbling skill and on-the-ball skills (performance time and passing accuracy in soccer-specific laboratory test. A significant main effect by age was found in all measured variables except in fat, in peripheral awareness and in passing accuracy. In discriminant analysis 63.9% (λ = 0.603, F = 4.600, p < 0.01 of the players were classified correctly based on physical fitness and general perceptual motor skills into three ability groups originally classified with performance time in soccer-specific laboratory test. Correlation co- efficient analysis with-in age groups revealed that variables associated with performance time in soccer-specific laboratory test were peripheral awareness (r = 0.72, p < 0.01 in 10-year-olds; testosterone (r = -0.70, p < 0.05, dribbling skill (r = 0.73, p < 0.01 and passing skill (r = 0.73, p < 0.01 in 12-year-olds; agility (r = 0.79, p < 0.01, counter movement jump (r = - 0.62, p < 0.01, dribbling skill (r = 0.80, p < 0.01 and passing skill (r = 0.58, p < 0. 05 in 14-year olds. Corresponding relationships with passing accuracy were weight (r = 0.59, p < 0.05, fat (r = 0.66, p < 0.05, 10m sprint (r = 0.71, p < 0.01 and countermovement jump (r = -0.64, p < 0.05 in 10-year-olds; Eye-Hand-Foot coordination (r = 0.63, p < 0.05 in 14-year- olds. The relationship between soccer-specific anticipation time and performance time in soccer- specific

  10. Perfil bioquímico del músculo Gluteus medius enequinos con distinto historial en carreras de resistencia Biochemical profile of the Gluteus medius muscle in horses with different performance records

    Directory of Open Access Journals (Sweden)

    J.L.L. RIVERO

    1998-01-01

    activities changedsignificantly with the increase of sampling depth within the muscle. Citratesynthase and 3-OH-acyl-CoA-dehydrogenase activities increased by 60% and75%, respectively, and that of lactate dehydrogenase decreased by 23% fromsurface to deep sampling depths. When lactate dehydrogenase/citrate synthaseand lactate dehydrogenase/ 3-OH-acyl-CoA-dehydrogenase enzyme activityratios were regressed on sampling depth in order to describe the generalmetabolic profile of the muscle, a strong linear relationship was foundin both performance groups (P<0.001. The highest intercepts of theseregression lines, found in moderate performers when compared to excellentperformers (P<0.001 and P<0.01 for both ratios, clearly show thatthe best performing endurance horses have a greater aerobic capacity anda relatively lower anaerobic capacity in the Gluteus medius musclethan those horses that have been moderately endurance raced. These resultsshow that fibre metabolic profile of this muscle is directly related tothe athletic ability of the horse for endurance events

  11. 大规模面向对象有限元程序的并行性能监测%Parallel performance profile of large-scale object-oriented finite element software

    Institute of Scientific and Technical Information of China (English)

    王海兵

    2011-01-01

    通过重载MPI消息传递函数,在重载的MPI函数中调用MPE库中各日志记录函数,实现了大规模面向对象有限元程序自定义并行性能监测.对一个典型冲击动力学问题进行了16 CPU的并行有限元模拟,通过并行性能监测对其有限元并行算法进行了分析.%MPI functions in the large-scale object-oriented finite element software were overloaded to cany out user defined parallel performance profiling. Log functions in Multi-Processing Environment (MPE) library were inserted to MPI functions when the MPI functions were overloaded. A typical impact simulation has been carried out using 16 CPUs, and the simulation process was monitored. Parallel finite element algorithm which was used in the simulation has been evaluated by analyzing the monitor results.

  12. Perfil funcional de comunicação e desempenho sócio-cognitivo de adolescentes autistas institucionalizados Functional communicative profile and social-cognitive performance of institutionalized autistic adolescents

    Directory of Open Access Journals (Sweden)

    Danielle Azarias Defense

    2011-12-01

    Full Text Available OBJETIVO: o objetivo dessa pesquisa foi descrever as características funcionais da comunicação de adolescentes autistas institucionalizados, ao longo de um período de aproximadamente seis meses, nos aspectos de: número de atos comunicativos por minuto, proporção de interpessoalidade da comunicação e proporção de utilização dos meios comunicativos gestual, vocal e verbal assim como descrever as características do desempenho sócio-cognitivo dos sujeitos ao longo desse período. MÉTODOS: foram sujeitos dessa pesquisa oito adolescentes autistas institucionalizados que foram avaliados durante seis meses quanto ao perfil funcional de comunicação e ao desempenho sócio-cognitivo. Os dados obtidos foram submetidos à análise estatística não paramétrica. RESULTADOS: foi observada evolução quanto ao número de atos comunicativos por minuto e à proporção de funções comunicativas interpessoais, mas não foi observada evolução significativa quanto aos aspectos sócio-cognitivos. CONCLUSÃO: foi possível observar evolução na linguagem em adolescentes autistas institucionalizados num período de tempo de seis meses, mas não foi possível identificar correlações com o desempenho sócio-cognitivo.PURPOSE: this study aims at describing the functional communication characteristics of institutionalized autistic adolescents for a period of six months approximately as for: number of communicative acts per minute, interpersonal proportion and means of proportion communication use (gestural, vocal, verbal as well as to describe the subjects' characteristics as for social cognitive performance in this period. METHODS: the subjects were eight institutionalized adolescents with autism. Their functional communicative profile and social-cognitive performance were assessed during a six-month period and resulting data were analyzed with non-parametric statistic methods. RESULTS: it was possible to observe that there was an improvement in

  13. Generic methodology for calibrating profiling nacelle lidars

    DEFF Research Database (Denmark)

    Borraccino, Antoine; Courtney, Michael; Wagner, Rozenn

    is calibrated rather than a reconstructed parameter. This contribution presents a generic methodology to calibrate profiling nacelle-mounted lidars. The application of profiling lidars to wind turbine power performance and corresponding need for calibration procedures is introduced in relation to metrological...... standards. Further, two different calibration procedure concepts are described along with their strengths and weaknesses. The main steps of the generic methodology are then explained and illustrated by calibration results from two types of profiling lidars. Finally, measurement uncertainty assessment...

  14. Effect of adding crushed Pimpinella anisum, Nigella sativa seeds and Thymus vulgaris mixture to antibiotics-free rations of vaccinated and non-vaccinated male broilers on growth performance, antibody titer and haematological profile

    Directory of Open Access Journals (Sweden)

    Mamoun Z. Athamneh

    2010-04-01

    Full Text Available This research explores an experimental study conducted to investigate the effect of crushed Pimpinella anisum (PA, Nigella sativa (NS seeds and Thymus vulgaris (TV mixture as a feed additive on growth performance and mortality rate (MR, selected antibodies titer (Ab’s and blood hematological profile of vaccinated and non-vaccinated Lohman male broiler chicks fed free-antibiotics ration. A total of 400 one-day old chicks were distributed into 16 groups (4 treatment x 4 replicates x 25chicks. The experiment lasted from one to 42 days of age. The statistical findings of this experiment prove that the use of medicinal plants mixture improves live body weight, body weight gain, feed conversion ratio and MR of vaccinated male broilers at 21 and 42 days of age. antibodies titer against infectious bronchitis and infectious bursal disease of non-vaccinated and vaccinated male broilers were significantly improved at 21 and 42 days as a result of the addition of medicinal plant mixture to the basal ration. Concerning Newcastle disease, the use of PA, NS and TV mixture did not reflect in any additional improvement of Ab's than vaccines did. The addition of medicinal plants mixture increases WBC's, RBC's, thrombocytes count and Hb concentration of vaccinated and non-vaccinated male broilers at 21 days of age. Meanwhile, heterophils, lymphocytes and monocytes of vaccinated male broilers (VMB were significantly improved by adding medicinal plant mixture to their basal diet. Moreover, at 42 days of age the use of PA, NS seeds and TV mixture indicate significant increase in total WBC’s, lymphocytes and monocytes and monocytes count of VMB and non-vaccinated male broiler (NVMB. No significant differences were noticed in RBC’s and Hct as a result of feeding crushed medicinal plants mixture.

  15. Criminal psychological profiling: validities and abilities.

    Science.gov (United States)

    Kocsis, Richard N

    2003-04-01

    Criminal psychological profiling has attained unprecedented recognition despite little empirical evidence to support its validity and the absence of any thorough exposition of the skills involved with the technique. This article reports on the empirically derived conclusions of studies that sought to examine the accuracy and skill of various groups performing a profiling task. The conclusions provide some support for the contention that professional profilers can produce a more accurate prediction of an unknown offender in comparison to other studied groups. The results also give an indication of the type of skills required for proficient profiling.

  16. The effect of chromium as chromium propionate on growth performance, carcass traits, meat quality, and the fatty acid profile of fat from pigs fed no supplemented dietary fat, choice white grease, or tallow.

    Science.gov (United States)

    Jackson, A R; Powell, S; Johnston, S L; Matthews, J O; Bidner, T D; Valdez, F R; Southern, L L

    2009-12-01

    The purpose of this research was to investigate the effect of Cr as chromium propionate (CrProp) on growth performance, carcass traits, meat quality, and the fatty acid profile of fat from pigs fed no supplemented dietary fat, choice white grease (CWG), or tallow. An experiment was conducted with 108 crossbred Yorkshire gilts assigned in a randomized complete block design based on BW (average initial and final BW were 29 +/- 3 and 109 +/- 7 kg, respectively) and allotted within block to a 2 x 3 factorial arrangement of treatments. The treatment arrangement consisted of 2 levels of Cr supplementation (0 and 200 microg/kg in the form of CrProp) and 3 dietary fat sources (no added fat, CWG, or tallow). Each treatment was replicated 6 times with 3 pigs per replicate pen. The experiment was conducted over time with 3 replicates in each of 2 trials. A 4-phase grower-finisher feeding program was used. Dietary treatments were 1) a corn-soybean meal (C-SBM) diet with no added fat; 2) a C-SBM diet with 4% added tallow; 3) a C-SBM diet with 4% added CWG; 4) diet 1 + 200 microg/kg of Cr as CrProp; and 5) diet 2 + 200 microg/kg of Cr; 6) diet 3 + 200 microg/kg of Cr. Addition of Cr did not affect (P > 0.10) growth performance, but did decrease (P = 0.05) 10th-rib backfat and increase (P = 0.03) percentage of muscle. Gain:feed was increased (P = 0.003) and ADFI was decreased (P = 0.03) by fat addition. Fat addition increased HCW (P = 0.05) and dressing percent (P = 0.03). Average backfat, 9th-rib LM cook loss, and 10th-rib LM drip loss and total loss were decreased (P = 0.02 to 0.04) by tallow. Belly bending on both the teatline and scribe side were increased (P = 0.01 to 0.03) by CWG. Iodine values on belly fat samples were decreased (P = 0.02) by Cr supplementation. In addition, iodine values on belly and loin fat samples were increased (P = 0.001) by CWG. Overall, Cr supplementation decreased backfat and the iodine value of belly fat and increased the percentage of muscle.

  17. Study on Rail Profile Optimization Based on the Nonlinear Relationship between Profile and Wear Rate

    Directory of Open Access Journals (Sweden)

    Jianxi Wang

    2017-01-01

    Full Text Available This paper proposes a rail profile optimization method that takes account of wear rate within design cycle so as to minimize rail wear at the curve in heavy haul railway and extend the service life of rail. Taking rail wear rate as the object function, the vertical coordinate of rail profile at range optimization as independent variable, and the geometric characteristics and grinding depth of rail profile as constraint conditions, the support vector machine regression theory was used to fit the nonlinear relationship between rail profile and its wear rate. Then, the profile optimization model was built. Based on the optimization principle of genetic algorithm, the profile optimization model was solved to achieve the optimal rail profile. A multibody dynamics model was used to check the dynamic performance of carriage running on optimal rail profile. The result showed that the average relative error of support vector machine regression model remained less than 10% after a number of training processes. The dynamic performance of carriage running on optimized rail profile met the requirements on safety index and stability. The wear rate of optimized profile was lower than that of standard profile by 5.8%; the allowable carrying gross weight increased by 12.7%.

  18. Metabolite profiles of common Stemphylium species

    DEFF Research Database (Denmark)

    Andersen, Birgitte; Solfrizzo, Michelle; Visconti, Angelo

    1995-01-01

    Thirty-three isolates of Stemphylium spp. have been analysed for their metabolite profiles. Five metabolites, stemphylin, stemphyloxin II, stemphyperylenol, stemphol and a stemphol related compound, have been detected by high-performance liquid chromatography and thin-layer chromatography...

  19. DNA profiles from fingermarks.

    Science.gov (United States)

    Templeton, Jennifer E L; Linacre, Adrian

    2014-11-01

    Criminal investigations would be considerably improved if DNA profiles could be routinely generated from single fingermarks. Here we report a direct DNA profiling method that was able to generate interpretable profiles from 71% of 170 fingermarks. The data are based on fingermarks from all 5 digits of 34 individuals. DNA was obtained from the fingermarks using a swab moistened with Triton-X, and the fibers were added directly to one of two commercial DNA profiling kits. All profiles were obtained without increasing the number of amplification cycles; therefore, our method is ideally suited for adoption by the forensic science community. We indicate the use of the technique in a criminal case in which a DNA profile was generated from a fingermark on tape that was wrapped around a drug seizure. Our direct DNA profiling approach is rapid and able to generate profiles from touched items when current forensic practices have little chance of success.

  20. GHGRP Industrial Profiles

    Science.gov (United States)

    EPA's Greenhouse Gas Reporting Program periodically produces detailed profiles of the various industries that report under the program. These profiles contain detailed analyses. This page hosts data highlights for all sectors.

  1. Microwave Radiometer Profiler

    Data.gov (United States)

    Oak Ridge National Laboratory — The microwave radiometer profiler (MWRP) provides vertical profiles of temperature, humidity, and cloud liquid water content as a function of height or pressure at...

  2. Generic methodology for calibrating profiling nacelle lidars

    OpenAIRE

    Borraccino, Antoine; Courtney, Michael; Wagner, Rozenn

    2015-01-01

    Improving power performance assessment by measuring at different heights has been demonstrated using ground-based profiling LIDARs. More recently, nacelle-mounted lidars studies have shown promising capabilities to assess power performance. Using nacelle lidars avoids the erection of expensive meteorology masts, especially offshore. A new generation of commercially developed profiling nacelle lidars has sophisticated measurement capabilities.As for any other measuring system, lidars measureme...

  3. Effects of long-term supplementation of dairy cow diets with rumen-protected conjugated linoleic acids (CLA) on performance, metabolic parameters and fatty acid profile in milk fat.

    Science.gov (United States)

    Pappritz, Julia; Meyer, Ulrich; Kramer, Ronny; Weber, Eva-Maria; Jahreis, Gerhard; Rehage, Jürgen; Flachowsky, Gerhard; Dänicke, Sven

    2011-04-01

    The supplementation of conjugated linoleic acids (CLA) to the rations of dairy cows represents an opportunity to reduce the content of milk fat. Therefore, CLA have the potential beneficial effect of reducing energy requirements of the early lactating cow. The present study aimed at the examination of long-term and posttreatment effects of dietary CLA intake on performance, variables of energy metabolism-like plasma levels of non esterified fatty acids (NEFA) and beta-hydroxybutyrate (BHB), and fatty acid profile in milk fat. Forty-six pregnant German Holstein cows were assigned to one of three dietary treatments: (1) 100 g/ d of control fat supplement (CON), (2) 50 g/d of control fat supplement and 50 g/ d of CLA supplement (CLA-1) and (3) 100 g/d of CLA supplement (CLA-2). The lipid-encapsulated CLA supplement consisted of approximately 10% of trans-10, cis-12 CLA and cis-9, trans-11 CLA each. The experiment started 1 d after calving and continued for about 38 weeks, divided into a supplementation (26 weeks) and a depletion period (12 weeks). Over the first 7 weeks of treatment, 11 and 16% reductions in dry matter intake compared to control were observed for the cows fed CLA-1 and CLA-2 supplements respectively. Consequently, the calculated energy balance for these two CLA groups was lower compared to the control. Plasma levels of NEFA and BHB remained unaffected. Later in lactation the highest CLA supplementation resulted in a reduction of milk fat content of 0.7%. However, no reduction in milk fat yield, and accordingly no milk fat depression (MFD), could be shown. The trans-10, cis-12 CLA in milk fat increased with increasing dietary CLA supplementation in a dose-dependent manner. The proportion of C16 in milk fat was decreased by the highest CLA supplementation. With the exception of an increase in plasma glucose level in the CLA-2 group, no post-treatment effects were observed. Overall, under the conditions of the present study no improvement in the

  4. Contributions of the maternal uterine environment and piglet genotype on weaning survivability potential: II. Piglet growth, lactation performance, milk composition, and piglet blood profiles during lactation following reciprocal embryo transfers between Meishan and White crossbred gilts.

    Science.gov (United States)

    Miles, J R; Vallet, J L; Ford, J J; Freking, B A; Oliver, W T; Rempel, L A

    2015-04-01

    Crossbreeding studies between Meishan (MS) and Large White (LW) pigs have illustrated that increased piglet growth before weaning is attributed to the maternal genotype of LW dams. The objective of this study was to determine the contributions of the maternal uterine environment (MUE), piglet genotype (PigG), piglet age (PA), and their interactions on piglet growth, lactation performance, milk composition, and piglet blood profiles during lactation following reciprocal embryo transfers between MS and White crossbred (WC) gilts. Twenty-five successful pregnancies were generated by embryo transfer in 2 farrowing years representing all MUE × PigG combinations: MS × MS (n = 4 litters), MS × WC (n = 7 litters), WC × MS (n = 7 litters), and WC × WC (n = 7 litters). At d 1 and 10 and at weaning, piglets (n = 147, n = 96, and n = 94, respectively) were weighed and blood samples were collected and measured for hematocrit, hemoglobin, glucose, nitrogen, NEFA, albumin, lactate, and cortisol. In addition, sows were manually milked from a medial mammary gland to determine milk composition. All data were analyzed by ANOVA using MIXED model procedures with the fixed effects of MUE, PigG, PA, and their interactions. Piglet weight was greater (P piglets from WC dams compared to MS dams at d 10 and weaning but not at d 1. In addition, ADG were greater (P piglets from WC dams compared to MS dams throughout lactation. However, milk composition was greater (P piglets, irrespective of MUE, at d 1 of lactation and in MS piglets from MS dams at d 10 of lactation. Blood glucose was greater (P = 0.01) at d 1 in piglets from WC dams regardless of PigG but, at weaning, glucose was greater (P = 0.01) in WC piglets regardless of MUE. Serum NEFA levels were greater (P = 0.02) in piglets from MS dams throughout the lactation period. This study demonstrated that WC dams were superior to MS dams for piglet growth during lactation, in agreement with previous crossbreeding studies. However

  5. Influence of diets enriched with different vegetable oils on the performance and fatty acid profile of Nile tilapia (Oreochromis niloticus fingerlings = Influência das dietas contendo diferentes óleos vegetais na performance e perfil em ácidos graxos de alevinos de tilápia do Nilo (Oreochromis niloticus

    Directory of Open Access Journals (Sweden)

    Nilson Evelázio de Souza

    2006-07-01

    Full Text Available The fatty acid profile of the carcass of Nile tilapia (Oreochromis niloticus fingerlings fed diets enriched with different soybean, canola, sunflower, flaxseed, rice, and corn oils was examined. The results showed that palmitic (16:0, stearic (18:0, oleic (18:1n-9, linoleic (18:2 n-6, and linolenic (18:3 n-3 acids were the predominant fatty acids in all vegetable oil, diet, and fish carcass samples analyzed. Flaxseed oil presented the highest amount of linolenic acid (45.63%, while the other vegetable oils had percentages lower than 5.0%. Neither of the vegetable oils used affected the performance of tilapia fingerlings and they can be utilized in Nile tilapia fingerling diets. However, in relation to the carcass fatty acid profile, the use of flaxseed oil in Nile tilapia fingerling diet is recommended. Foram examinados o perfil de ácidos graxos nas carcaças de alevinos de tilápia do Nilo (Oreochromis niloticus alimentados com dietas enriquecidas com diferentes óleos vegetais (soja, canola, girassol, linhaça, arroz e milho. Os resultados indicaram que o ácido palmítico (16:0, esteárico (18:0, oléico (18:1n-9, linoleico (18;2n-6 e linolênico (18:3n-3 foram os ácidos predominantes em todas as frações analisadas (no óleo vegetal, dietas e carcaças dos peixes. O óleo de linhaça apresentou o maior valor de ácido linolênico (45,63%, quanto aos outros óleos vegetais tiveram uma percentagem menor que 5,0%. Todos os óleos vegetais não afetaram a performance dos alevinos e podem ser utilizados nas dietas, entretanto, em relação a qualidade nutricional o uso do óleo de linhaça é recomendado em dietas de alevinos de tilápia.

  6. Conselhos Municipais de Alimentação Escolar em Santa Catarina: caracterização e perfil de atuação Municipal School Nutrition Councils in Santa Catarina, Brazil: characterization and performance profile

    Directory of Open Access Journals (Sweden)

    Gilberto Veras Caldeiras

    2013-04-01

    Full Text Available O objetivo deste estudo é avaliar os Conselhos Municipais de Alimentação Escolar (CAE no Estado de Santa Catarina. Investigação transversal em amostra de municípios catarinenses (n = 152; 52%. Entrevistaram-se preferencialmente os presidentes dos CAE, pesquisando-se o perfil dos conselheiros, as atribuições realizadas e a relação do CAE com outras instâncias de controle social. Utilizou-se Regressão de Poisson para obter razões de prevalências bruta e ajustada. No modelo ajustado seguiu-se uma abordagem hierárquica. A maioria dos conselhos analisava a prestação de contas, fiscalizava os recursos, zelava pela qualidade do PNAE em todos os níveis, orientava o armazenamento dos alimentos, participava da elaboração do cardápio, acompanhava a compra de gêneros e tinha regimento interno. Entretanto, apenas 22,4% realizavam todas as atribuições com frequência maior ou igual à anual. Verificou-se associação positiva entre uma boa atuação do CAE e existência de relação com outros conselhos locais. A sensibilização dos CAE e o estímulo à atua­ção articulada com outros conselhos e atores envolvidos com a segurança alimentar e nutricional, são essenciais para a garantia do direito à alimentação saudável e adequada nas escolas.The aim of this study is to assess Municipal School Nutrition Councils (CAEs of the Brazilian School Nutrition Program (PNAE in the state of Santa Catarina, Brazil. A cross-sectional study was conducted with a sample of municipalities in the state (n = 152; 52%. CAE presidents were interviewed and asked about the counselor profile, attributions performed and the relation of CAEs with other local councils. Poisson regression analysis was conducted to obtain unadjusted and adjusted prevalence ratios and the adjusted model adopted a hierarchic approach. The majority of councils analyzed their accounting reports, monitored resources and strived for quality of the CAEs at all levels. They

  7. Sensing the wind profile

    Energy Technology Data Exchange (ETDEWEB)

    Pena, A.

    2009-03-15

    This thesis consists of two parts. The first is a synopsis of the theoretical progress of the study that is based on a number of journal papers. The papers, which constitute the second part of the report, aim to analyze, measure, and model the wind prole in and beyond the surface layer by combining observations from cup anemometers with lidars. The lidar is necessary to extend the measurements on masts at the Horns Rev offshore wind farm and over at land at Hoevsoere, Denmark. Both sensing techniques show a high degree of agreement for wind speed measurements performed at either sites. The wind speed measurements are averaged for several stability conditions and compare well with the surface-layer wind profile. At Hoevsoere, it is sufficient to scale the wind speed with the surface friction velocity, whereas at Horns Rev a new scaling is added, due to the variant roughness length. This new scaling is coupled to wind prole models derived for flow over the sea and tested against the wind proles up to 160 m at Horns Rev. The models, which account for the boundary-layer height in stable conditions, show better agreement with the measurements than compared to the traditional theory. Mixing-length parameterizations for the neutral wind prole compare well with length-scale measurements up to 300 m at Hoevsoere and 950 m at Leipzig. The mixing-length-derived wind proles strongly deviate from the logarithmic wind prole, but agree better with the wind speed measurements. The length-scale measurements are compared to the length scale derived from a spectral analysis performed up to 160 m at Hoevsoere showing high agreement. Mixing-length parameterizations are corrected to account for stability and used to derive wind prole models. These compared better to wind speed measurements up to 300 m at Hoevsoere than the surface-layer wind prole. The boundary-layer height is derived in nearneutral and stable conditions based on turbulent momentum uxes only and in unstable conditions

  8. Extremal periodic wave profiles

    Directory of Open Access Journals (Sweden)

    E. van Groesen

    2007-01-01

    Full Text Available As a contribution to deterministic investigations into extreme fluid surface waves, in this paper wave profiles of prescribed period that have maximal crest height will be investigated. As constraints the values of the momentum and energy integrals are used in a simplified description with the KdV model. The result is that at the boundary of the feasible region in the momentum-energy plane, the only possible profiles are the well known cnoidal wave profiles. Inside the feasible region the extremal profiles of maximal crest height are "cornered" cnoidal profiles: cnoidal profiles of larger period, cut-off and periodically continued with the prescribed period so that at the maximal crest height a corner results.

  9. RATIONAL STEEL CORRUGATED PROFILE DESIGN

    Directory of Open Access Journals (Sweden)

    V. V. Kachurenko

    2015-08-01

    Full Text Available Purpose. The work sets forth the search results of new, more efficient design solutions for metal silos, namely, the analysis of existing types of profiles cross-section in a steel wall of such silo and development of less material-intensive section of corrugated profile.Methodology. To achieve the set goal there were researched the existing types of capacitive structure profiles and their strain-stress state under the load. The analysis was performed on the results of computational experiments. The prototype object was mathematical computer models. The calculations were made using the finite-element method. For computational experiment there was used the design-computing system Structure CAD for Windows. Findings. In this work there were obtained the data allowing to assess work of the profiles and to find more effective type of cross-section in terms of its material consumption. In the process of joint study of the authors a new type of profile for capacitive structures was developed; it has higher utilization efficiency and the attachment point of individual steel sheets with this type of profile. Both solutions are easy to install, reliable in operation and can be manufactured in the conditions of modern industrial production using standard equipment, materials and components. Originality. A new type of corrugated profile cross-section for steel silo walls was proposed; it has higher load carrying capacity and rigidity and allows reducing the metal thickness without changing the structure carrying capacity that results in material consumption reduction of the whole structure.For this and similar types of profiles there was designed and proposed the attachment point of individual corrugated sheets screwed with extending flange, which enables the unit connection in case of small size corrugations, where the distance is not sufficient to accommodate the bolt cap between the individual corrugations. Practical value.Application of the proposed

  10. YOUNG ATHLETES' MOTIVATIONAL PROFILES

    Directory of Open Access Journals (Sweden)

    Juan Antonio Moreno Murcia

    2007-06-01

    Full Text Available The aim of this study was to examine the relationship between motivational characteristics and dispositional flow. In order to accomplish this goal, motivational profiles emerging from key constructs within Achievement Goal Theory and Self-Determination Theory were related to the dispositional flow measures. A sample of 413 young athletes (Age range 12 to 16 years completed the PMCSQ-2, POSQ, SMS and DFS measures. Cluster analysis results revealed three profiles: a "self-determined profile" characterised by higher scores on the task-involving climate perception and on the task orientation; a "non-self-determined profile", characterised by higher scores on ego-involving climate perception and ego orientation; and a "low self-determined and low non-self-determined profile" which had the lowest dispositional flow. No meaningful differences were found between the "self-determined profile" and the "non-self-determined profile" in dispositional flow. The "self-determined profile" was more commonly associated with females, athletes practising individual sports and those training more than three days a week. The "non-self-determined profile" was more customary of males and athletes practising team sports as well as those training just two or three days a week

  11. Pharmacology profiling of chemicals and proteins

    DEFF Research Database (Denmark)

    Kringelum, Jens Vindahl

    of pharmaceuticals, a process referred to as pharmacology profiling. Pharmacology profiling of chemical and protein based pharmaceuticals has been proven valuable in a number studies [2], however missing values in the drug-protein interaction matrix limits the profile for novel or less studied compounds....... This limitation complicates adverse effect assessment in the early drug-development phase, thus contributing to drugattrition. Prediction models offer the possibility to close these gaps and provide more complete pharmacology profiles, however improvements in performances are required for these tools to serve...... as an alternative to experimentally obtained measurements. Here I present several different tools that aid pharmacology profiling of the two main classes of pharmaceuticals; chemicals (small molecules) and proteins (biopharmaceuticals). Biopharmaceuticals have the inherent risks of eliciting an immune response due...

  12. Ceramide profile in hypohidrotic ectodermal dysplasia

    DEFF Research Database (Denmark)

    Jungersted, J. M.; Høgh, Julie Kaae; Hellgren, Lars

    2012-01-01

    Background. Hypohidrotic ectodermal dysplasia (HED) is a rare genetic disease. The clinical presentation includes lack of sweating ability, and an often widely spread dermatitis resembling atopic dermatitis (AD). In AD, the skin‐barrier defect is partly ascribed to the altered lipid profile...... in the stratum corneum and partly to mutations of the filaggrin genes. To our knowledge, no data are available about the epidermal lipid profile of HED. Aim. To compare the ceramide profile for patients with HED and AD. Methods. The ceramide profile and ceramide/cholesterol ratio were compared between patients...... with HED (n = 7) and patients with AD (n = 21), using cyanoacrylate to take biopsy samples from the stratum corneum. Lipids were extracted from the biopsies and analysed using high‐performance thin‐layer chromatography. Results. The lipid profiles of HED and AD were similar in distribution, apart from...

  13. The first decade of MALDI protein profiling

    DEFF Research Database (Denmark)

    Albrethsen, Jakob

    2011-01-01

    MALDI protein profiling has identified several important challenges in omics-based biomarker research. First, research into the analytical performance of a novel omics-platform of potential diagnostic impact must be carried out in a critical manner and according to common guidelines. Evaluation...... studies should be performed at an early time and preferably before massive advancement into explorative biomarker research. In particular, MALDI profiling underscores the need for an adequate understanding of the causal relationship between molecular abundance and the quantitative measure in multivariate...... biomarker research. Secondly, MALDI profiling has raised awareness of the significant risk of false-discovery in biomarker research due to several confounding factors, including sample processing and unspecific host-response to disease. Here, the experience from MALDI profiling supports that a central...

  14. The alkaloid profiles of Lupinus sulphureus.

    Science.gov (United States)

    Cook, Daniel; Lee, Stephen T; Gardner, Dale R; Pfister, James A; Welch, Kevin D; Green, Benedict T; Davis, T Zane; Panter, Kip E

    2009-02-25

    Lupines are common plants on the rangelands in the western United States. Lupines contain alkaloids that can be toxic and teratogenic causing congenital birth defects (crooked calf disease). One such lupine, Lupinus sulphureus, occurs in parts of Oregon, Washington, and British Columbia. Specimens of L. sulphureus from field collections and herbaria were evaluated taxonomically and by chemical means. A total of seven distinct alkaloid profiles and the individual alkaloids associated with each profile were identified. Each alkaloid profile was unique in its geographical distribution and its potential risk to livestock. In conclusion, taxonomic classification is not sufficient to determine risk, as chemical characterization of the alkaloids must also be performed.

  15. Spiking the expectancy profiles

    DEFF Research Database (Denmark)

    Hansen, Niels Chr.; Loui, Psyche; Vuust, Peter

    Melodic expectations have long been quantified using expectedness ratings. Motivated by statistical learning and sharper key profiles in musicians, we model musical learning as a process of reducing the relative entropy between listeners' prior expectancy profiles and probability distributions...... learning over varying timescales enables listeners to generate expectations with reduced entropy....

  16. Household electricity demand profiles

    DEFF Research Database (Denmark)

    Marszal, Anna Joanna; Heiselberg, Per Kvols; Larsen, Olena Kalyanova

    2016-01-01

    Highlights •A 1-min resolution household electricity load model is presented. •Model adapts a bottom-up approach with single appliance as the main building block. •Load profiles are used to analyse the flexibility potential of household appliances. •Load profiles can be applied in other domains, e...

  17. Chemical profiling of explosives

    NARCIS (Netherlands)

    Brust, G.M.H.

    2014-01-01

    The primary goal of this thesis is to develop analytical methods for the chemical profiling of explosives. Current methodologies for the forensic analysis of explosives focus on identification of the explosive material. However, chemical profiling of explosives becomes increasingly important, as

  18. Reinforced aerodynamic profile

    DEFF Research Database (Denmark)

    2010-01-01

    The present invention relates to the prevention of deformations in an aerodynamic profile caused by lack of resistance to the bending moment forces that are created when such a profile is loaded in operation. More specifically, the invention relates to a reinforcing element inside an aerodynamic...

  19. A step toward universal competency profiler

    OpenAIRE

    Avsec, Stanislav; Kaučič, Branko; Ramšak, Maja

    2015-01-01

    Last decade, the competences, competency and competency profiling have been recognized as the core information and process to provide basics for implementation of efficient interchangeable widely recognized education and worldwide employment. Competences are components of a job which are reflected in behaviour that are observable in a workplace. A list of the knowledge, skills, and abilities necessary to perform a job well is determined as competency profile. Types of skills li...

  20. Profiling the Mobile Customer

    DEFF Research Database (Denmark)

    Jessen, Pernille Wegener; King, Nancy J.

    2010-01-01

    of significant concerns about privacy and data protection. This second article in a two part series on "Profiling the Mobile Customer" explores how to best protect consumers' privacy and personal data through available mechanisms that include industry self-regulation, privacy-enhancing technologies......Mobile customers are increasingly being tracked and profiled by behavioural advertisers to enhance delivery of personalized advertising. This type of profiling relies on automated processes that mine databases containing personally-identifying or anonymous consumer data, and it raises a host...... discusses the current limitations of using technology to protect consumers from privacy abuses related to profiling. Concluding that industry self-regulation and available privacy-enhancing technologies will not be adequate to close important privacy gaps related to consumer profiling without legislative...

  1. Estimating Cognitive Profiles Using Profile Analysis via Multidimensional Scaling (PAMS)

    Science.gov (United States)

    Kim, Se-Kang; Frisby, Craig L.; Davison, Mark L.

    2004-01-01

    Two of the most popular methods of profile analysis, cluster analysis and modal profile analysis, have limitations. First, neither technique is adequate when the sample size is large. Second, neither method will necessarily provide profile information in terms of both level and pattern. A new method of profile analysis, called Profile Analysis via…

  2. A ranking index for quality assessment of forensic DNA profiles forensic DNA profiles

    Science.gov (United States)

    2010-01-01

    Background Assessment of DNA profile quality is vital in forensic DNA analysis, both in order to determine the evidentiary value of DNA results and to compare the performance of different DNA analysis protocols. Generally the quality assessment is performed through manual examination of the DNA profiles based on empirical knowledge, or by comparing the intensities (allelic peak heights) of the capillary electrophoresis electropherograms. Results We recently developed a ranking index for unbiased and quantitative quality assessment of forensic DNA profiles, the forensic DNA profile index (FI) (Hedman et al. Improved forensic DNA analysis through the use of alternative DNA polymerases and statistical modeling of DNA profiles, Biotechniques 47 (2009) 951-958). FI uses electropherogram data to combine the intensities of the allelic peaks with the balances within and between loci, using Principal Components Analysis. Here we present the construction of FI. We explain the mathematical and statistical methodologies used and present details about the applied data reduction method. Thereby we show how to adapt the ranking index for any Short Tandem Repeat-based forensic DNA typing system through validation against a manual grading scale and calibration against a specific set of DNA profiles. Conclusions The developed tool provides unbiased quality assessment of forensic DNA profiles. It can be applied for any DNA profiling system based on Short Tandem Repeat markers. Apart from crime related DNA analysis, FI can therefore be used as a quality tool in paternal or familial testing as well as in disaster victim identification. PMID:21062433

  3. Phytohormone Profiling across the Bryophytes.

    Directory of Open Access Journals (Sweden)

    Lenka Záveská Drábková

    Full Text Available Bryophytes represent a very diverse group of non-vascular plants such as mosses, liverworts and hornworts and the oldest extant lineage of land plants. Determination of endogenous phytohormone profiles in bryophytes can provide substantial information about early land plant evolution. In this study, we screened thirty bryophyte species including six liverworts and twenty-four mosses for their phytohormone profiles in order to relate the hormonome with phylogeny in the plant kingdom.Samples belonging to nine orders (Pelliales, Jungermanniales, Porellales, Sphagnales, Tetraphidales, Polytrichales, Dicranales, Bryales, Hypnales were collected in Central and Northern Bohemia. The phytohormone content was analysed with a high performance liquid chromatography electrospray tandem-mass spectrometry (HPLC-ESI-MS/MS.As revealed for growth hormones, some common traits such as weak conjugation of both cytokinins and auxins, intensive production of cisZ-type cytokinins and strong oxidative degradation of auxins with abundance of a major primary catabolite 2-oxindole-3-acetic acid were pronounced in all bryophytes. Whereas apparent dissimilarities in growth hormones profiles between liverworts and mosses were evident, no obvious trends in stress hormone levels (abscisic acid, jasmonic acid, salicylic acid were found with respect to the phylogeny.The apparent differences in conjugation and/or degradation strategies of growth hormones between liverworts and mosses might potentially show a hidden link between vascular plants and liverworts. On the other hand, the complement of stress hormones in bryophytes probably correlate rather with prevailing environmental conditions and plant survival strategy than with plant evolution.

  4. Developing the CUAHSI Metadata Profile

    Science.gov (United States)

    Piasecki, M.; Bermudez, L.; Islam, S.; Beran, B.

    2004-12-01

    The Hydrologic Information System (HIS), of the Consortium of Universities for the Advancement of Hydrologic Science Inc., (CUAHSI), has as one of its goals to improve access to large volume, high quality, and heterogeneous hydrologic data sets. This will be attained in part by adopting a community metadata profile to achieve consistent descriptions that will facilitate data discovery. However, common standards are quite general in nature and typically lack domain specific vocabularies, complicating the adoption of standards for specific communities. We will show and demonstrate the problems encountered in the process of adopting ISO standards to create a CUAHSI metadata profile. The final schema is expressed in a simple metadata format, Metadata Template File (MTF), to leverage metadata annotations/viewer tools already developed by the San Diego Super Computer Center. The steps performed to create an MTF starting from ISO 19115:2003 are the following: 1) creation of ontologies using the Web Ontology Language (OWL) for ISO:19115 2003 and related ISO/TC 211 documents; 2) conceptualization in OWL of related hydrologic vocabularies such as NASA's Global Change Master Directory and units from the Hydrologic Handbook; 3) definition of CUAHSI profile by importing and extending the previous ontologies; 4) explicit creation of CUAHSI core set 5) export of the core set to MTF); 6) definition of metadata blocks for arbitrary digital objects (e.g. time series vs static-spatial data) using ISO's methodology for feature cataloguing; and 7) export of metadata blocks to MTF.

  5. Qualitative Value Profiling

    DEFF Research Database (Denmark)

    Duus, Henrik Johannsen; Bjerre, Mogens

    2015-01-01

    Qualitative value profiling (QVP) is a relatively unknown method of strategic analysis for companies in international business-to-business settings. The purpose of QVP is to reduce the information complexity that is faced by international companies in dealing with business partners. The QVP method...... allows the development of 1) profiles of the target country in which operations are to take place, 2) profiles of the buying center (i.e. the group of decision makers) in the partner company, and 3) profiles of the product/service offering. It also allows the development of a semantic scaling method...... for deeper analysis of all involved factors. This paper presents the method and compares and contrasts it with other similar methods like the PESTELE method known from corporate strategy, the STEEPAL method known from scenario analysis, and the Politics-Institutions-Economy (PIE) framework known from...

  6. Profile of Older Americans

    Science.gov (United States)

    ... covers 15 topical areas, including population, income and poverty, living arrangements, education, health, and caregiving. A Profile ... Elder Justice Innovation Grants Late Life Domestic Violence World Elder Abuse Awareness Day State Grants to Enhance ...

  7. Prescription Drug Profiles PUF

    Data.gov (United States)

    U.S. Department of Health & Human Services — This release contains the Prescription Drug Profiles Public Use Files (PUFs) drawn from Medicare prescription drug claims for the year of the date on which the...

  8. Beach Profile Locations

    Data.gov (United States)

    California Department of Resources — Beaches are commonly characterized by cross-shore surveys. The resulting profiles represent the elevation of the beach surface and nearshore seabed from the back of...

  9. Fishing Community Profiles

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — To enable fisheries managers to comply with National Standard 8 (NS8), NMFS social scientists around the nation are preparing fishing community profiles that present...

  10. Wind Profiling Radar

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Clutter present in radar return signals as used for wind profiling is substantially removed by carrying out a Daubechies wavelet transformation on a time series of...

  11. Profiles in Cancer Research

    Science.gov (United States)

    These articles put a face to some of the thousands of individuals who contribute to NCI’s cancer research efforts. The profiles highlight the work of scientists and clinicians and describe the circumstances and motivation behind their work.

  12. Profiling the Mobile Customer

    DEFF Research Database (Denmark)

    Jessen, Pernille Wegener; King, Nancy J.

    2010-01-01

    Mobile customers are increasingly being tracked and profiled by behavioural advertisers to enhance delivery of personalized advertising. This type of profiling relies on automated processes that mine databases containing personally-identifying or anonymous consumer data, and it raises a host...... of significant concerns about privacy and data protection. This second article in a two part series on "Profiling the Mobile Customer" explores how to best protect consumers' privacy and personal data through available mechanisms that include industry self-regulation, privacy-enhancing technologies...... and legislative reform. 1 It discusses how well privacy and personal data concerns related to consumer profiling are addressed by two leading industry self-regulatory codes from the UK and the U.S. that aim to establish fair information practices for behavioural advertising by their member companies. It also...

  13. Fire Management Species Profiles

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The objective of the Fire Management Species Profile project is to identify habitat management objectives that are specific, measurable, achievable, clearly...

  14. Beach Profile Locations

    Data.gov (United States)

    California Department of Resources — Beaches are commonly characterized by cross-shore surveys. The resulting profiles represent the elevation of the beach surface and nearshore seabed from the back of...

  15. The Microwave Temperature Profiler (PERF)

    Science.gov (United States)

    Lim, Boon; Mahoney, Michael; Haggerty, Julie; Denning, Richard

    2013-01-01

    The JPL developed Microwave Temperature Profiler (MTP) has recently participated in GloPac, HIPPO (I to V) and TORERO, and the ongoing ATTREX campaigns. The MTP is now capable of supporting the NASA Global Hawk and a new canister version supports the NCAR G-V. The primary product from the MTP is remote measurements of the atmospheric temperature at, above and below the flight path, providing for the vertical state of the atmosphere. The NCAR-MTP has demonstrated unprecedented instrument performance and calibration with plus or minus 0.2 degrees Kelvin flight level temperature error. Derived products include curtain plots, isentropes, lapse rate, cold point height and tropopause height.

  16. Developing of robot flexible processing system for shipbuilding profile steel

    Institute of Scientific and Technical Information of China (English)

    姚舜; 邱涛; 楼松年; 王宏杰

    2003-01-01

    A robot flexible processing system of shipbuilding profile steel was developed. The system consists of computer integrated control and robot. An off-line programming robot was used for marking and cutting of shipbuilding profile steel. In the system the deformation and position error of profile steel can be detected by precise sensors, and figure position coordinate error resulted from profile steel deformation can be compensated by modifying traveling track of robotic arm online. The practical operation results show that the system performance can meet the needs of profile steel processing.

  17. Cherenkov light-based beam profiling for ultrarelativistic electron beams

    Energy Technology Data Exchange (ETDEWEB)

    Adli, E., E-mail: Erik.Adli@fys.uio.no [Department of Physics, University of Oslo, N-0316 Oslo (Norway); SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States); Gessner, S.J.; Corde, S.; Hogan, M.J. [SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States); Bjerke, H.H. [SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States); Department of Physics, Norwegian University of Science and Technology, N-7491 Trondheim (Norway)

    2015-05-21

    We describe a beam profile monitor design based on Cherenkov light emitted from a charged particle beam in an air gap. The main components of the profile monitor are silicon wafers used to reflect Cherenkov light onto a camera lens system. The design allows for measuring large beam sizes, with large photon yield per beam charge and excellent signal linearity with beam charge. The profile monitor signal is independent of the particle energy for ultrarelativistic particles. Different design and parameter considerations are discussed. A Cherenkov light-based profile monitor has been installed at the FACET User Facility at SLAC. We report on the measured performance of this profile monitor.

  18. Perfiles estudiantiles de metas de logro, instrucciones de meta y retroalimentación externa: su efecto en el desempeño de tareas matemáticas y afectividad. Student profiles of achievement goals, goal instructions and external feedback: Their effect on mathematical task performance and affect

    Directory of Open Access Journals (Sweden)

    Fotini Dina

    2009-10-01

    Full Text Available

    Este estudio investiga cómo los perfiles estudiantiles de metas de logro y otras características personales, junto con factores situacionales como las instrucciones de orientación a la meta y la retroalimentación externa influyen en el rendimiento y en las experiencias y emociones metacognitivas de los estudiantes mientras resuelven problemas matemáticos. En el estudio participaron 870 alumnos de 7º y 9º curso de ambos género. Los estudiantes completaron una serie de cuestionarios de auto-informe que evaluaban la actitud hacia las matemáticas, la ansiedad ante los exámenes, el autoconcepto matemático y las orientaciones de meta. También se midió la habilidad para las matemáticas y el rendimiento en tareas matemáticas junto con las experiencias y emociones metacognitivas, y el gusto por las tareas. Un análisis jerárquico de conglomerados arrojó 8 perfiles estudiantiles diferentes, y sólo algunos de ellos implicaban metas de orientación al logro. Una serie de MANOVAs puso de manifiesto los efectos significativos de perfil y tratamiento sobre rendimiento en la tarea, experiencias y emociones metacognitivas, además de una interacción significativa entre perfil y tratamiento en el caso de las valoraciones del esfuerzo.

    Palabras clave: Metas de orientación al logro, perfiles estudiantiles, retroalimentación, experiencias metacognitivas, intereses.

    The present study investigated how student profiles of achievement goals and other person characteristics along with situational factors, such as goal-orientation instructions and external feedback, influence performance, metacognitive experiences and emotions during mathematical problem solving. The study involved 870 students of seventh and ninth grade of both genders. Students completed a series of self-report questionnaires tapping attitude toward mathematics, test anxiety, mathematics self-concept, and achievement goal orientations. Ability in

  19. BWR AXIAL PROFILE

    Energy Technology Data Exchange (ETDEWEB)

    J. Huffer

    2004-09-28

    The purpose of this calculation is to develop axial profiles for estimating the axial variation in burnup of a boiling water reactor (BWR) assembly spent nuclear fuel (SNF) given the average burnup of an assembly. A discharged fuel assembly typically exhibits higher burnup in the center and lower burnup at the ends of the assembly. Criticality safety analyses taking credit for SNF burnup must account for axially varying burnup relative to calculations based on uniformly distributed assembly average burnup due to the under-burned tips. Thus, accounting for axially varying burnup in criticality analyses is also referred to as accounting for the ''end effect'' reactivity. The magnitude of the reactivity change due to ''end effect'' is dependent on the initial assembly enrichment, the assembly average burnup, and the particular axial profile characterizing the burnup distribution. The set of bounding axial profiles should incorporate multiple BWR core designs and provide statistical confidence (95 percent confidence that 95 percent of the population is bound by the profile) that end nodes are conservatively represented. The profiles should also conserve the overall burnup of the fuel assembly. More background on BWR axial profiles is provided in Attachment I.

  20. Local flow management/profile descent algorithm. Fuel-efficient, time-controlled profiles for the NASA TSRV airplane

    Science.gov (United States)

    Groce, J. L.; Izumi, K. H.; Markham, C. H.; Schwab, R. W.; Thompson, J. L.

    1986-01-01

    The Local Flow Management/Profile Descent (LFM/PD) algorithm designed for the NASA Transport System Research Vehicle program is described. The algorithm provides fuel-efficient altitude and airspeed profiles consistent with ATC restrictions in a time-based metering environment over a fixed ground track. The model design constraints include accommodation of both published profile descent procedures and unpublished profile descents, incorporation of fuel efficiency as a flight profile criterion, operation within the performance capabilities of the Boeing 737-100 airplane with JT8D-7 engines, and conformity to standard air traffic navigation and control procedures. Holding and path stretching capabilities are included for long delay situations.

  1. Impact of Minnesota's "Profile of Learning"

    Directory of Open Access Journals (Sweden)

    Patricia G. Avery

    2003-02-01

    Full Text Available In 1990, the Minnesota State Board of Education declared its intention to develop a "results-oriented graduation requirement" based on student achievement as opposed to the usual credit/course completion requirement. In addition to a traditional test of basic skills, the state began developing the Profile of Learning, a set of performance-based standards grounded in a constructivist educational philosophy, an approach that differs from the content-based standards found in many states. The Profile was controversial from its inception. Conservatives characterized the Profile as too process- oriented and as lacking subject-matter content; teachers reported that the Profile required a significant amount of additional teacher preparation time; and parents, who were not adequately informed about the Profile, questioned the purpose of the Profile. Teachers were frustrated with the confusing and sometimes contradictory directions they received from the Minnesota Department of Children, Families, and Learning charged with implementing the Profile. In 2000-2001, we surveyed and interviewed selected secondary English and social studies teachers in the state about their perceptions of the Profile’s impact on teaching and learning. Among the positive perceptions was an increase in students’ higher order thinking, students’ understanding of criteria for quality work, and teachers conversations with one another about instructional issues. Increased teacher preparation time and decreased enjoyment of teaching were among the negative perceptions. Teachers also experienced difficulty adopting performance assessment techniques. When teachers believed they received effective preparation and adequate resources for working with the Profile, they were much more likely to report beneficial effects in terms of teaching and learning. The majority of teachers, however, rated their preparation and resources as "fair" or "poor." Results are discussed in terms of

  2. Epidemiology of isolated meniscal injury and its effect on performance in athletes from the National Basketball Association.

    Science.gov (United States)

    Yeh, Peter C; Starkey, Chad; Lombardo, Stephen; Vitti, Gary; Kharrazi, F Daniel

    2012-03-01

    The current incidence and outcomes of meniscal injury have not been quantified in professional athletes. To describe the incidence, risk, amount of time lost, and effect on performance for isolated meniscal injury in athletes from the National Basketball Association (NBA). Demographic factors predicting the risk of meniscal tears and the effect of injury in return to play were also investigated. Descriptive epidemiology study. A centralized database was queried to identify meniscal injuries occurring in the NBA over 21 seasons. The frequency of injury, time lost, game exposures, and incidence, rate, and risk were calculated. The preinjury and postinjury player efficiency rating (PER) was used to identify changes in player performance. We identified 129 isolated meniscal tears in NBA athletes during a 21-season span. From this number, 77 (59.7%) involved the lateral meniscus and 52 (40.3%) the medial meniscus. Injuries occurred more frequently in games. The lateral meniscus had a statistically significant higher injury rate. Both left and right knees were equally affected. The number of days missed for lateral meniscal tears and medial meniscal tears was 43.8 ± 35.7 days and 40.9 ± 29.7 days, respectively, and was not statistically different. There was a significant inverse relationship between age and rate of lateral meniscal tears, with lateral meniscal tears more likely to occur up to age 30 years; beyond that medial meniscal tears were more common. Players with a body mass index (BMI) greater than 25 had a significantly increased risk of meniscal tears compared with players with a BMI less than 25, specifically with an increased risk of lateral meniscal tears. Twenty-five players (19.4%) did not return to play. For those who did, upon returning to competition, there was no statistical change in PER from their preinjury status, and the mean number of seasons completed was 4.1 ± 3.7 seasons. The lateral meniscus is more frequently torn than the medial meniscus

  3. Country profile: Hungary

    Energy Technology Data Exchange (ETDEWEB)

    1991-09-01

    Country Profile: Hungary has been prepared as a background document for use by US Government agencies and US businesses interested in becoming involved with the new democracies of Eastern Europe as they pursue sustainable economic development. The focus of the Profile is on energy and highlights information on Hungary's energy supply, demand, and utilization. It identifies patterns of energy usage in the important economic sectors, especially industry, and provides a preliminary assessment for opportunities to improve efficiencies in energy production, distribution and use by introducing more efficient technologies. The use of more efficient technologies would have the added benefit of reducing the environmental impact which, although is not the focus of the report, is an issue that effects energy choices. The Profile also presents considerable economic information, primarily in the context of how economic restructuring may affect energy supply, demand, and the introduction of more efficient technologies.

  4. Country profile: Hungary

    Energy Technology Data Exchange (ETDEWEB)

    1991-09-01

    Country Profile: Hungary has been prepared as a background document for use by US Government agencies and US businesses interested in becoming involved with the new democracies of Eastern Europe as they pursue sustainable economic development. The focus of the Profile is on energy and highlights information on Hungary`s energy supply, demand, and utilization. It identifies patterns of energy usage in the important economic sectors, especially industry, and provides a preliminary assessment for opportunities to improve efficiencies in energy production, distribution and use by introducing more efficient technologies. The use of more efficient technologies would have the added benefit of reducing the environmental impact which, although is not the focus of the report, is an issue that effects energy choices. The Profile also presents considerable economic information, primarily in the context of how economic restructuring may affect energy supply, demand, and the introduction of more efficient technologies.

  5. Detonation Wave Profile

    Energy Technology Data Exchange (ETDEWEB)

    Menikoff, Ralph [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-12-14

    The Zel’dovich-von Neumann-Doering (ZND) profile of a detonation wave is derived. Two basic assumptions are required: i. An equation of state (EOS) for a partly burned explosive; P(V, e, λ). ii. A burn rate for the reaction progress variable; d/dt λ = R(V, e, λ). For a steady planar detonation wave the reactive flow PDEs can be reduced to ODEs. The detonation wave profile can be determined from an ODE plus algebraic equations for points on the partly burned detonation loci with a specified wave speed. Furthermore, for the CJ detonation speed the end of the reaction zone is sonic. A solution to the reactive flow equations can be constructed with a rarefaction wave following the detonation wave profile. This corresponds to an underdriven detonation wave, and the rarefaction is know as a Taylor wave.

  6. Constructing Data Curation Profiles

    Directory of Open Access Journals (Sweden)

    Michael Witt

    2009-12-01

    Full Text Available This paper presents a brief literature review and then introduces the methods, design, and construction of the Data Curation Profile, an instrument that can be used to provide detailed information on particular data forms that might be curated by an academic library. These data forms are presented in the context of the related sub-disciplinary research area, and they provide the flow of the research process from which these data are generated. The profiles also represent the needs for data curation from the perspective of the data producers, using their own language. As such, they support the exploration of data curation across different research domains in real and practical terms. With the sponsorship of the Institute of Museum and Library Services, investigators from Purdue University and the University of Illinois interviewed 19 faculty subjects to identify needs for discovery, access, preservation, and reuse of their research data. For each subject, a profile was constructed that includes information about his or her general research, data forms and stages, value of data, data ingest, intellectual property, organization and description of data, tools, interoperability, impact and prestige, data management, and preservation. Each profile also presents a specific dataset supplied by the subject to serve as a concrete example. The Data Curation Profiles are being published to a public wiki for questions and discussion, and a blank template will be disseminated with guidelines for others to create and share their own profiles. This study was conducted primarily from the viewpoint of librarians interacting with faculty researchers; however, it is expected that these findings will complement a wide variety of data curation research and practice outside of librarianship and the university environment.

  7. First ultraperformance liquid chromatography based strategy for profiling intact proteins in complex matrices: application to the evaluation of the performance of olive ( Olea europaea L.) stone proteins for cultivar fingerprinting.

    Science.gov (United States)

    Esteve, Clara; Del Río, Carmen; Marina, María Luisa; García, María Concepción

    2010-07-28

    There is a clear need for accelerating protein separations by HPLC. Different proposals have been developed including the use of perfusion and monolithic stationary phases. Nevertheless, these stationary phases, in some occasions, do not provide enough efficiency to resolve these large molecules when they are present in complex matrices. Although ultraperformance liquid chromatography (UPLC) columns have been successfully used for the efficient and rapid separation of small molecules, this is the first time these columns were proposed for the separation of intact proteins in a real complex matrix: the olive stone. Two different strategies were employed for the extraction of olive proteins: enzymatic assisted extraction and buffered extraction. Five different columns traditionally employed for the separation of proteins were used, and results were compared with those obtained when using different sub-2 microm particle columns. Separations obtained with sub-2 mum particle columns significantly improved the separations obtained with the other columns. This paper also demonstrates the applicability of protein profiles obtained from the olive stone for the discrimination among olive varieties.

  8. Enterprise Surveys : Nicaragua Country Profile 2010

    OpenAIRE

    World Bank; International Finance Corporation

    2011-01-01

    The enterprise surveys focus on the many factors that shape the business environment. The qualitative and quantitative data collected through the surveys connect a country s business environment characteristics with firm productivity and performance. The country profile for Nicaragua is based on data from the enterprise surveys conducted by the World Bank. The benchmarks include the averag...

  9. Impacts of rudder profiles on ship manoeuvrability

    NARCIS (Netherlands)

    Liu, J.; Quadvlieg, F.; Hekkenberg, R.G.

    2015-01-01

    The performance of a ship’s rudder largely determines its manoeuvrability, which includes turning ability, initial turning ability, yaw-checking ability and course-keeping ability. However, existing empirical formulas for rudder forces do not concern the rudder profile. This paper discusses the

  10. Impacts of rudder profiles on ship manoeuvrability

    NARCIS (Netherlands)

    Liu, J.; Quadvlieg, F.; Hekkenberg, R.G.

    2015-01-01

    The performance of a ship’s rudder largely determines its manoeuvrability, which includes turning ability, initial turning ability, yaw-checking ability and course-keeping ability. However, existing empirical formulas for rudder forces do not concern the rudder profile. This paper discusses the impa

  11. The significance of the integumentary profile.

    Science.gov (United States)

    Satravaha, S; Schlegel, K D

    1987-11-01

    Profile analysis was performed on 180 Thai female subjects with ages ranging from 16 to 21 years. Seventy were of Chinese origin. The determination of the profile analysis mean values was based on the methods of Schwarz, Subtelny, Ricketts, Burstone, and Schwartz. The results were compared to Caucasian standards and to the findings of our previous study on a Javanese population. For the profile forms, our investigated groups showed mainly prognathic faces (75% to 84%). A "shift backward" profile flow dominated. We found a "prognathic face" combined with a "shift backward" in 50% to 60% of the Asian subjects analyzed. Our soft-tissue profile results (approximately 165 +/- 6 degrees) showed less convexity than that of the Caucasians and there was no significant difference in overall profile between the 2 Thai groups (approximately 134 +/- 5 degrees); this is in the range given by Subtelny (141 degrees to 131 degrees) except for that of the Javanese subjects. For the lip analysis, we listed a posterior position or a lip position upon the esthetic line between 60% to 70% of both Thai groups with respect to the upper lip and only 28% to 33% for the lower lip. The Javanese group, however, showed 90% anterior position of the upper lip and 93% of the lower lip to this line. It is significant that proper blending of the integumentary profile produces an esthetically pleasing face and this varies in different ethnic groups. A good combination could even make a "prognathic face shift backward" very acceptable as illustrated by a profile analysis of Miss Thailand, 1984.(ABSTRACT TRUNCATED AT 250 WORDS)

  12. Country Profiles, Pakistan.

    Science.gov (United States)

    Hardee, J. Gilbert; Satterthwaite, Adaline P.

    A profile of Pakistan is sketched in this paper. Emphasis is placed on the nature, scope, and accomplishments of population activities in the country. Topics and sub-topics include: location and description of the country; population (size, growth patterns, age structure, urban/rural distribution, ethnic and religious composition, migration,…

  13. Sensing the wind profile

    DEFF Research Database (Denmark)

    Pena Diaz, Alfredo

    prole. The boundary-layer height is derived in nearneutral and stable conditions based on turbulent momentum uxes only and in unstable conditions based on profiles of aerosol backscatter from ceilometer measurements. The lidar measuring technique is used to estimate momentum flux, showing high agreement...

  14. A temperature profiler

    Digital Repository Service at National Institute of Oceanography (India)

    Peshwe, V.B.; Desa, E.

    An instrument developed for measuring temperature profiles at sea in depth or time scales is described. PC-based programming offers flexibility in setting up the instrument for the mode of operation prior to each cast. A real time clock built...

  15. A Danish Profiling System

    DEFF Research Database (Denmark)

    Rosholm, Michael; Staghøj, Jonas; Svarer, Michael;

    2006-01-01

    This paper describes the statistical model used for profiling new unemployed workers in Denmark. When a worker – during his or her first six months in unemployment – enters the employment office for the first time, this model predicts whether or not he or she will be unemployed for more than six ...

  16. Country Education Profiles: Algeria.

    Science.gov (United States)

    International Bureau of Education, Geneva (Switzerland).

    One of a series of profiles prepared by the Cooperative Educational Abstracting Service, this brief outline provides basic background information on educational principles, system of administration, structure and organization, curricula, and teacher training in Algeria. Statistics provided by the Unesco Office of Statistics show enrollment at all…

  17. Country Profiles, Malaysia.

    Science.gov (United States)

    Marzuki, Ariffin Bin; Peng, J. Y.

    A profile of Malaysia is sketched in this paper. Emphasis is placed on the nature, scope, and accomplishments of population activities in the country. Topics and sub-topics include: location and description of the country; population (size, growth patterns, age structure, urban/rural distribution, ethnic and religious composition, migration,…

  18. English Teaching Profile: Mexico.

    Science.gov (United States)

    British Council, London (England). English Language and Literature Div.

    This profile of the English language teaching situation in Mexico examines the role of English in society and in the educational system. It is noted that the extent to which English is used in Mexico is affected by the country's proximity to the United States. The educational system is described, with emphasis on English instruction which begins…

  19. Geographic profiling survey

    NARCIS (Netherlands)

    Emeno, Karla; Bennell, Craig; Snook, Brent; Taylor, Paul Jonathon

    Geographic profiling (GP) is an investigative technique that involves predicting a serial offender?s home location (or some other anchor point) based on where he or she committed a crime. Although the use of GP in police investigations appears to be on the rise, little is known about the procedure

  20. COMPENDEX Profile Adjustment Manual.

    Science.gov (United States)

    Standera, Oldrich

    If an information system is to survive, the users must be satisfied that it meets their needs promptly and consistently. It is essential to react quickly to any undesired result such as an extemely high or low output, too low a relevance or recall, or both. The search editor should feel responsbile not only for the profile setup but also for its…

  1. Performing Performance Design Anglonationally

    DEFF Research Database (Denmark)

    2016-01-01

    Video recording of pecha kucha style bricolage aural enactment of an international version of performance design......Video recording of pecha kucha style bricolage aural enactment of an international version of performance design...

  2. Performing Performance Design Anglonationally

    DEFF Research Database (Denmark)

    2016-01-01

    Video recording of pecha kucha style bricolage aural enactment of an international version of performance design......Video recording of pecha kucha style bricolage aural enactment of an international version of performance design...

  3. High-resolution PTP1B inhibition profiling combined with high-performance liquid chromatography-high-resolution mass spectrometry-solid-phase extraction-nuclear magnetic resonance spectroscopy: Proof-of-concept and antidiabetic constituents in crude extract of Eremophila lucida.

    Science.gov (United States)

    Tahtah, Yousof; Wubshet, Sileshi G; Kongstad, Kenneth T; Heskes, Allison Maree; Pateraki, Irini; Møller, Birger Lindberg; Jäger, Anna K; Staerk, Dan

    2016-04-01

    Type 2 diabetes (T2D) constituted 90% of the global 387 million diabetes cases in 2014. The enzyme protein-tyrosine phosphatase 1B (PTP1B) has been recognized as a therapeutic target for treatment of T2D and its adverse complications. With the aim of accelerating the investigation of complex natural sources, such as crude plant extracts, for potential PTP1B inhibitors, we have developed a bio-analytical platform combining high-resolution PTP1B inhibition profiling and high-performance liquid chromatography-high-resolution mass spectrometry-solid-phase extraction-nuclear magnetic resonance spectroscopy, i.e., HR-bioassay/HPLC-HRMS-SPE-NMR. Human recombinant PTP1B enzyme was used for the microplate-based PTP1B inhibition assay, which was optimized for pH and substrate concentration to be compatible with rate measurements within the 10 min incubation time. Subsequently, analytical-scale HPLC-based microfractionation followed by colorimetric microplate-based PTP1B bioassaying enabled construction of a high-resolution inhibition profile corresponding to the HPLC profile. The high-resolution PTP1B inhibition profiling was validated using an artificial mixture of known PTP1B inhibitors and non-inhibiting compounds as negative controls. Finally, a proof-of-concept study with a real sample was performed using crude ethyl acetate extract of the phytochemically hitherto unexplored plant Eremophila lucida. This led to the identification of the first viscidane type diterpene, i.e., 5-hydroxyviscida-3,14-dien-20-oic acid (9) as PTP1B inhibitor with an IC50 value of 42.0 ± 5.9 μM. In addition, a series of flavonoids, i.e., luteolin (1), dinatin (3a), tricin (3b), 3,6-dimethoxyapigenin (4), jaceidin (5), and cirsimaritin (6) as well as a cembrene diterpene, (3Z, 7E, 11Z)-15-hydroxycembra-3,7,11-trien-19-oic acid (8), were also identified for the first time from E. lucida.

  4. Numerical Simulation on Flow Performance and Blade Profile Optimal Design of Light Load Type Axial Flow Pump%轻载型轴流泵的流场分析和叶型优化

    Institute of Scientific and Technical Information of China (English)

    张宇; 管仁伟; 安伟; 徐峰

    2013-01-01

    在不同工况下,采用商业软件Numeca的Fine/Turbo模块,对包含叶轮、导叶、弯管、喇叭管的轻载型轴流泵进行了全流道的三维湍流数值模拟计算,并在与已有试验数据进行了较好吻合的基础上,对其内部流场进行了详细地数值分析,通过分析轴流泵内部的流动特点,找出了造成原模型流动损失的可能原因,发现由于局部结构设计不合理,流道内产生了漩涡区.针对这一问题提出了改进措施,采用商业软件Numeca的Design3D模块对叶轮叶型压力面和吸力面进行多参数化优化.结果表明,控制压力面、吸力面型线可以有效控制叶片出口处的漩涡,改进后的流道内存在的涡团和流动损失减少,叶轮的水力效和扬程等性能参数相对提高.%Using a commercial software Numeca Fine/Turbo, a numerical algorithm is presented to simulate three-dimensional turbulent flow for a light load type axial flow pump impeller, including the impeller, the guide vane and the bend pipe under different conditions. Through analyzing the axial flow pump internal flow characteristics, we find out the flow loss of the original model, such as vast vortexes areas and wall flow separations. Furthermore, we use the Numeca/Design3D software to optimize the parameters and to redesign the blade profile. The results show that changing the pressure and suctione lines can effectively control the blade of the swirl, resulting in the vortex and flow loss reduction and increasing the efficiency of the impeller hydraulic lift.

  5. Pulsar polarisation below 200 MHz: Average profiles and propagation effects

    NARCIS (Netherlands)

    Noutsos, A.; Sobey, C.; Kondratiev, V.I.; Weltevrede, P.; Verbiest, J.P.W.; Karastergiou, A.; Kramer, M.; Kuniyoshi, M.; Alexov, A.; Breton, R.P.; Bilous, A.V.; Cooper, S.; Falcke, H.; Grießmeier, J.M.; Hassall, T.E.; Hessels, J.W.T.; Keane, E.F.; Osłowski, S.; Pilia, M.; Serylak, M.; Stappers, B.W.; ter Veen, S.; van Leeuwen, J.; Zagkouris, K.; Anderson, K.; Bähren, L.; Bell, M.; Broderick, J.; Carbone, D.; Cendes, Y.; Coenen, T.; Corbel, S.; Eislöffel, J.; Fender, R.; Garsden, H.; Jonker, P.; Law, C.; Markoff, S.; Masters, J.; Miller-Jones, J.; Molenaar, G.; Osten, R.; Pietka, M.; Rol, E.; Rowlinson, A.; Scheers, B.; Spreeuw, H.; Staley, T.; Stewart, A.; Swinbank, J.; Wijers, R.; Wijnands, R.; Wise, M.; Zarka, P.; van der Horst, A.

    2015-01-01

    Aims. We present the highest-quality polarisation profiles to date of 16 non-recycled pulsars and four millisecond pulsars, observed below 200 MHz with the LOFAR high-band antennas. Based on the observed profiles, we perform an initial investigation of expected observational effects resulting from t

  6. Pulsar polarisation below 200 MHz: Average profiles and propagation effects

    NARCIS (Netherlands)

    Noutsos, A.; Sobey, C.; Kondratiev, V.I.; Weltevrede, P.; Verbiest, J.P.W.; Karastergiou, A.; Kramer, M.; Kuniyoshi, M.; Alexov, A.; Breton, R.P.; Bilous, A.V.; Cooper, S.; Falcke, H.; Griessmeier, J.-M.; Hassall, T.E.; Hessels, J.W.T.; Keane, E.F.; Oslowski, S.; Pilia, M.; Serylak, M.; Stappers, B.W.; Veen, S. ter; Leeuwen, J. van; Zagkouris, K.; Anderson, K.; Baehren, L.; Bell, M.E.; Broderick, J.; Carbone, D.; Cendes, Y.; Coenen, T.; Corbel, S.; Eisloeffel, J.; Fender, R.P.; Garsden, H.; Jonker, P.; Law, C.J.; Markoff, S.; Masters, J.; Miller-Jones, J.C.A.; Molenaar, G.; Osten, R.; Pietka, M.; Rol, E.; Rowlinson, A.; Scheers, L.H.A.; Spreeuw, H.; Staley, T.; Stewart, A.; Swinbank, J.; Wijers, R.A.M.J.; Wijnands, R.; Wise, M.W.; Zarka, P.; Horst, A. van der

    2015-01-01

    Aims: We present the highest-quality polarisation profiles to date of 16 non-recycled pulsars and four millisecond pulsars, observed below 200 MHz with the LOFAR high-band antennas. Based on the observed profiles, we perform an initial investigation of expected observational effects resulting from t

  7. Accelerating the Original Profile Kernel.

    Directory of Open Access Journals (Sweden)

    Tobias Hamp

    Full Text Available One of the most accurate multi-class protein classification systems continues to be the profile-based SVM kernel introduced by the Leslie group. Unfortunately, its CPU requirements render it too slow for practical applications of large-scale classification tasks. Here, we introduce several software improvements that enable significant acceleration. Using various non-redundant data sets, we demonstrate that our new implementation reaches a maximal speed-up as high as 14-fold for calculating the same kernel matrix. Some predictions are over 200 times faster and render the kernel as possibly the top contender in a low ratio of speed/performance. Additionally, we explain how to parallelize various computations and provide an integrative program that reduces creating a production-quality classifier to a single program call. The new implementation is available as a Debian package under a free academic license and does not depend on commercial software. For non-Debian based distributions, the source package ships with a traditional Makefile-based installer. Download and installation instructions can be found at https://rostlab.org/owiki/index.php/Fast_Profile_Kernel. Bugs and other issues may be reported at https://rostlab.org/bugzilla3/enter_bug.cgi?product=fastprofkernel.

  8. Fetal Biophysical Profile Scoring

    Directory of Open Access Journals (Sweden)

    H.R. HaghighatKhah

    2009-01-01

    Full Text Available   "nFetal biophysical profile scoring is a sonographic-based method of fetal assessment first described by Manning and Platt in 1980. "nThe biophysical profile score was developed as a method to integrate real-time observations of the fetus and his/her intrauterine environment in order to more comprehensively assess the fetal condition. These findings must be evaluated in the context of maternal/fetal history (i.e., chronic hypertension, post-dates, intrauterine growth restriction, etc, fetal structural integrity (presence or absence of congenital anomalies, and the functionality of fetal support structures (placental and umbilical cord. For example, acute asphyxia due to placental abruption may result in an absence of the acute variables of the biophysical profile score (fetal breathing movements, fetal movement, fetal tone, and fetal heart rate reactivity with a normal amniotic fluid volume. With post maturity the asphyxial event may be intermittent and chronic resulting in a decrease in amniotic fluid volume, but with the acute variables remaining normal. "nWhile the 5 components of the biophysical profile score have remained unchanged since 1980 (Manning, 1980, the definitions of a normal and abnormal parameter have evolved with increasing experience. "nIn 1984 the definition of oligohydramnios was increased from < 1cm pocket of fluid to < 2.0 x 1.0 cm pocket. Oligohydramnios is now defined as a pocket of amniotic fluid < 2.0 x 2.0 cm (Manning, 1995a "nIf the four ultrasound variables are normal, the accuracy of the biophysical profile score was not found to be significantly improved by adding the non-stress test. As a result, in 1987 the profile score was modified to incorporate the non-stress test only when one of the ultrasound variables was abnormal (Manning 1987. Table 1 outlines the current definitions for quantifying a variable as present or absent. "nEach of the 5 components of the biophysical profile score does not have equal

  9. Return-to-Sport and Performance After Anterior Cruciate Ligament Reconstruction in National Basketball Association Players.

    Science.gov (United States)

    Harris, Joshua D; Erickson, Brandon J; Bach, Bernard R; Abrams, Geoffrey D; Cvetanovich, Gregory L; Forsythe, Brian; McCormick, Frank M; Gupta, Anil K; Cole, Brian J

    2013-11-01

    Anterior cruciate ligament (ACL) rupture is a significant injury in National Basketball Association (NBA) players. NBA players undergoing ACL reconstruction (ACLR) have high rates of return to sport (RTS), with RTS the season following surgery, no difference in performance between pre- and postsurgery, and no difference in RTS rate or performance between cases (ACLR) and controls (no ACL tear). Case-control. NBA players undergoing ACLR were evaluated. Matched controls for age, body mass index (BMI), position, and NBA experience were selected during the same years as those undergoing ACLR. RTS and performance were compared between cases and controls. Paired-sample Student t tests, chi-square, and linear regression analyses were performed for comparison of within- and between-group variables. Fifty-eight NBA players underwent ACLR while in the NBA. Mean player age was 25.7 ± 3.5 years. Forty percent of ACL tears occurred in the fourth quarter. Fifty players (86%) RTS in the NBA, and 7 players (12%) RTS in the International Basketball Federation (FIBA) or D-league. Ninety-eight percent of players RTS in the NBA the season following ACLR (11.6 ± 4.1 months from injury). Two players (3.1%) required revision ACLR. Career length following ACLR was 4.3 ± 3.4 years. Performance upon RTS following surgery declined significantly (P NBA following ACLR. Nearly all players RTS the season following surgery. Performance significantly declined from preinjury level; however, this was not significantly different from controls. ACL re-tear rate was low. There is a high RTS rate in the NBA after ACLR, with no difference in performance upon RTS compared with controls.

  10. ALENT SELECTION IN SPORTS AND ASSESSMENT OF THE PHYSICAL CHARACTERISTICS AND SOME PERFORMANCE PROFILES OF FEMALE CHILDREN BETWEEN 8-10 YEARS-OLD IN GUIDANCE TO SPORTS (ANKARA SAMPLE

    Directory of Open Access Journals (Sweden)

    Vedat AYAN

    2010-12-01

    Full Text Available ABSRACTIn this study it is aimed to examine some performance charecteristics, somatotype and anthropometric characteristics of female children- between 8 &10 years old - for sports training and talent identification.In this study 1777 volunteer secondary school female students, 9±1 years old, from 23 schools in Ankara, participated in the subject group. In our study 11 anthropometric measurements such as, skinfold ticknesses, circumference and width measurements were taken. Heath-Carter method was used to determine the somatotype characteristics. Of performance characteristics, standing long jump test, vertical jump test, sitting ball throwing test, 20 m. speed run test and shuttle run test were applied. The statistical analyses of the measurements were calculated by using SPSS 11.0. The mean somatotype values of the female students that participated were found as endomorphy 3,96±0.86 mesomorphy 3,65±1,14 ectomorphy 2,96±1,43 and the performance test mean values were as follows; vertical jump 17,27±4,09 cm standing long jump 94,72±16,83 cm, 20 m speed run test 4,76±0,47 sec, sitting ball throwing 78,16±23,39 cm, shuttle run test 19,19±7,37 shuttle.The results that we have reached through this study will contribute to the knowledge –available at present- about talent identification and talent selection in sports and to establishing the normative values and to benefiting the investments on sports and sportspeople at maximum level and to the studies done in this field in our country.

  11. Profiling and Preparation of Metabolites from Pyragrel in Human Urine by Online Solid-Phase Extraction Coupled with High Performance Liquid Chromatography Tandem Mass Spectrometry Followed by a Macroporous Resin-Based Purification Approach.

    Science.gov (United States)

    Zhao, Xin; Jiang, Jingjing; Yang, Guang; Huang, Jie; Yang, Guoping; He, Guangwei; Chu, Zhaoxing; Hang, Taijun; Fan, Guorong

    2017-03-21

    Pyragrel, a new anticoagulant drug, is derived from the molecular combination of ligustrazine and ferulic acid. Pyragrel showed significant inhibitory activity against platelet aggregation induced by adenosine diphosphate (ADP), and had been approved for a phase I clinical trial by CFDA. To characterize the metabolites of Pyragrel in human urine after intravenous administration, a reliable online solid-phase extraction couple with high performance liquid chromatography tandem mass spectrometry (online SPE-HPLC-MS(n)) method was conceived and applied. Five metabolites were detected and tentatively identified, which suggested that the major metabolic pathways of Pyragrel in human were double-bond reduction, double-bond oxidation, and then followed by glucuronide conjugation. Two main metabolites were then prepared using β-glucuronide hydrolysis and macroporous resin purification approach followed by preparative high-performance liquid chromatography (PHPLC) method, with their structures confirmed on the basis of nuclear magnetic resonance (NMR) data. This study provided information for the further study of the metabolism and excretion of Pyragrel.

  12. Effects of thermo-resistant non-starch polysaccharide degrading multi-enzyme on growth performance, meat quality, relative weights of body organs and blood profile in broiler chickens.

    Science.gov (United States)

    Mohammadi Gheisar, M; Hosseindoust, A; Kim, I H

    2016-06-01

    This research was conducted to study the performance and carcass parameters of broiler chickens fed diets supplemented with heat-treated non-starch polysaccharide degrading enzyme. A total of 432 one-day old Ross 308 broiler chickens were allocated to five treatments: (i) CON (basal diet), (ii) E1: CON + 0.05% multi-enzyme, (iii) E2: CON + 0.1% multi-enzyme, (iv) E3: CON + 0.05% thermo-resistant multi-enzyme and (v) E4: CON + 0.1% thermo-resistant multi-enzyme, each treatment consisted of six replications and 12 chickens in each replication. The chickens were housed in three floor battery cages during 28-day experimental period. On days 1-7, gain in body weight (BWG) improved by feeding the diets supplemented with thermo-resistant multi-enzyme. On days 7-21 and 1-28, chickens fed the diets containing thermo-resistant multi-enzyme showed improved (p thermo-resistant multi-enzyme affected the percentage of drip loss on d 1 (p thermo-resistant multi-enzyme did not affect the relative weights of organs but compared to CON group, relative weight of breast muscle increased and abdominal fat decreased (p thermo-resistant multi-enzyme showed higher (p thermo-resistant multi-enzyme improved performance of broiler chickens.

  13. Fatty acid profile of meat, diurnal changes in volatile fatty acids, rumen fluid parameters, and growth performance in Korean native (Hanwoo steers fed high- and low-forage diets supplemented with chromium-methionine

    Directory of Open Access Journals (Sweden)

    Bae-Hun Lee

    Full Text Available ABSTRACT The objective of this study was to determine the effects of forage level in diets supplemented with chromium-methionine (Cr-Met on rumen fluid parameters, meat fatty acid composition, and performance of Korean beef (Hanwoo steers. Twenty-three Hanwoo steers were used in this experiment. A completely randomized design and repeated measurements were used to analyze the data set. Beef steers were fed diets containing high (10 head; average body weight (BW = 525.1±27.5; forage:concentrate (F:C = 60:40 (60F and low (13 head; average BW = 531.8±32.4; F:C = 40:60 ratio (40F forage diets supplemented with Cr-Met for 60 d. Dry matter intake, BW, and feed efficiency were not different between the two treatment groups. Fatty acid composition of meat including myristate, stearate, and gamma linoleate was not different between the two groups; however, palmitate, palimtoleate, and linoleate were higher in 60F group than 40F group. Ammonia-N showed a higher trend in 40F group, whereas pH demonstrated higher values in 60F group. Ruminal acetate was higher in 60F group than 40F group and maintained a high trend throughout the sampling time, whereas no differences were found in ruminal propionate, butyrate, and valerate between two groups. A high-forage diet (60% improves meat quality and has no adverse effects on performance of Hanwoo steers.

  14. Corrosion issues of powder coated AA6060 aluminium profiles

    DEFF Research Database (Denmark)

    Din, Rameez Ud; Valgarðsson, Smári; Jellesen, Morten Stendahl

    2015-01-01

    In this study detailed microstructural investigation of the reason for unexpected corrosion of powder coated aluminium alloy AA6060 windows profiles has been performed. The results from this study reveals that the failure of the window profiles was originated from the surface defects present...... on the extruded AA6060 aluminium profile after metallurgical process prior to powder coating. Surface defects are produced due to intermetallic particles in the alloy, which disturb the flow during the extrusion process. The corrosion mechanism leading to the failure of the powder coated AA6060 aluminium profiles...

  15. Profile of success

    DEFF Research Database (Denmark)

    Dahlgaard, Jens Jørn; Nørgaard, Anders; Jakobsen, Søren

    1998-01-01

    What management skills must Europe's business leaders improve to achieve business excellence? Which country's leaders are best placed for success? Does the next generation have what it takes to compete? In the second half of their study of the leadership styles that drive business excellence, Jens...... Dahlgaard, Anders Nørgaard and Søren Jakobsen describe an excellent leadership profile that provides the answers....

  16. Qualitative Value Profiling

    DEFF Research Database (Denmark)

    Duus, Henrik Johannsen; Bjerre, Mogens

    2015-01-01

    Qualitative value profiling (QVP) is a relatively unknown method of strategic analysis for companies in international business-to-business settings. The purpose of QVP is to reduce the information complexity that is faced by international companies in dealing with business partners. The QVP method...... and consequently, for the advancement of international development. Further use of QVP is recommended and suggestions for future research are provided....

  17. High throughput drug profiling

    OpenAIRE

    Entzeroth, Michael; Chapelain, Béatrice; Guilbert, Jacques; Hamon, Valérie

    2000-01-01

    High throughput screening has significantly contributed to advances in drug discovery. The great increase in the number of samples screened has been accompanied by increases in costs and in the data required for the investigated compounds. High throughput profiling addresses the issues of compound selectivity and specificity. It combines conventional screening with data mining technologies to give a full set of data, enabling development candidates to be more fully compared.

  18. Wide HI profile galaxies

    CERN Document Server

    Brosch, Noah; Zitrin, Adi

    2011-01-01

    We investigate the nature of objects in a complete sample of 28 galaxies selected from the first sky area fully covered by ALFALFA, being well-detected and having HI profiles wider than 550 km/s. The selection does not use brightness, morphology, or any other property derived from optical or other spectral bands. We investigate the degree of isolation, the morphology, and other properties gathered or derived from open data bases and show that some objects have wide HI profiles probably because they are disturbed or are interacting, or might be confused in the ALFALFA beam. We identify a sub-sample of 14 galaxies lacking immediate interacting neighbours and showing regular, symmetric, two-horned HI profiles that we propose as candidate high-mass disk systems (CHMDs). We measure the net-Halpha emission from the CHMDs and combine this with public multispectral data to model the global star formation (SF) properties of each galaxy. The Halpha observations show SFRs not higher than a few solar masses per year. Sim...

  19. Response of laying hens to feeding low-protein amino acid-supplemented diets under high ambient temperature: performance, egg quality, leukocyte profile, blood lipids, and excreta pH

    Science.gov (United States)

    Torki, Mehran; Mohebbifar, Ahmad; Ghasemi, Hossein Ali; Zardast, Afshin

    2015-05-01

    An experiment was conducted to determine whether, by using a low-protein amino acid-supplemented diet, the health status, stress response, and excreta quality could be improved without affecting the productive performance of heat-stressed laying hens. The requirements for egg production, egg mass, and feed conversion ratio were also estimated using second-order equations and broken-line regression. A total of 150 Lohmann Selected Leghorn (LSL-Lite) hens were divided randomly into five groups of 30 with five replicates of six hens. The hens were raised for an 8-week period (52 to 60 weeks) in wire cages situated in high ambient temperature in an open-sided housing system. The five experimental diets (ME; 2,720 kcal/kg) varied according to five crude protein (CP) levels: normal-CP diet (control, 16.5 % CP) and low-CP diets containing 15.0, 13.5, 12.0, or 10.5 % CP. All experimental diets were supplemented with crystalline amino acids at the levels sufficient to meet their requirements. The results showed that under high temperature conditions, all productive performance and egg quality parameters in the birds fed with 15.0, 13.5, and 12.0 % CP diets were similar to those of birds fed with control diet (16.5 % CP), whereas feeding 10.5 % CP diet significantly decreased egg production and egg mass. Estimations of requirements were of 13.93 and 12.77 % CP for egg production, 14.62 and 13.22 % CP for egg mass, and 12.93 and 12.26 % CP for feed conversion ratio using quadratic and broken-line models, respectively. Egg yolk color index, blood triglyceride level, and excreta acidity were also significantly higher in birds fed with 12.0 and 10.5 % CP diets compared with those of control birds. The heterophil to lymphocyte ratio, as a stress indicator, was significantly decreased by 15.0, 13.5, and 12 % CP diets. On the basis of our findings, reducing dietary CP from 16.5 to 12.0 % and supplementing the diets with the essential amino acids showed merit for improving the

  20. Response of laying hens to feeding low-protein amino acid-supplemented diets under high ambient temperature: performance, egg quality, leukocyte profile, blood lipids, and excreta pH.

    Science.gov (United States)

    Torki, Mehran; Mohebbifar, Ahmad; Ghasemi, Hossein Ali; Zardast, Afshin

    2015-05-01

    An experiment was conducted to determine whether, by using a low-protein amino acid-supplemented diet, the health status, stress response, and excreta quality could be improved without affecting the productive performance of heat-stressed laying hens. The requirements for egg production, egg mass, and feed conversion ratio were also estimated using second-order equations and broken-line regression. A total of 150 Lohmann Selected Leghorn (LSL-Lite) hens were divided randomly into five groups of 30 with five replicates of six hens. The hens were raised for an 8-week period (52 to 60 weeks) in wire cages situated in high ambient temperature in an open-sided housing system. The five experimental diets (ME; 2,720 kcal/kg) varied according to five crude protein (CP) levels: normal-CP diet (control, 16.5 % CP) and low-CP diets containing 15.0, 13.5, 12.0, or 10.5 % CP. All experimental diets were supplemented with crystalline amino acids at the levels sufficient to meet their requirements. The results showed that under high temperature conditions, all productive performance and egg quality parameters in the birds fed with 15.0, 13.5, and 12.0 % CP diets were similar to those of birds fed with control diet (16.5 % CP), whereas feeding 10.5 % CP diet significantly decreased egg production and egg mass. Estimations of requirements were of 13.93 and 12.77 % CP for egg production, 14.62 and 13.22 % CP for egg mass, and 12.93 and 12.26 % CP for feed conversion ratio using quadratic and broken-line models, respectively. Egg yolk color index, blood triglyceride level, and excreta acidity were also significantly higher in birds fed with 12.0 and 10.5 % CP diets compared with those of control birds. The heterophil to lymphocyte ratio, as a stress indicator, was significantly decreased by 15.0, 13.5, and 12 % CP diets. On the basis of our findings, reducing dietary CP from 16.5 to 12.0 % and supplementing the diets with the essential amino acids showed merit for improving the

  1. Metabolic profiling of nuciferine in rat urine, plasma, bile and feces after oral administration using ultra-high performance liquid chromatography-diode array detection-quadrupole time-of-flight mass spectrometry.

    Science.gov (United States)

    Wu, Xiao-Lei; Wu, Ming-Jiang; Chen, Xin-Ze; Ma, Hao-Ling; Ding, Li-Qin; Qiu, Feng; Pan, Qin; Zhang, De-Qin

    2017-03-18

    Nuciferine, a major alkaloid found in Nelumbinis Folium, exhibits a broad spectrum of bioactivities, such as antiobesity, anti-diabetes and anti-inflammatory. However, many research regarding nuciferine focused on the extraction, isolation and biological activity, the metabolism is not comprehensively explained in vivo. Thence, the present of this paper is to establish a simple method for speculating metabolites of nuciferine. A total of 15 metabolites were detected and tentatively identified through ultra high performance liquid chromatography-diode array detection-quadrupole time-of-flight mass spectrometry (UHPLC-DAD-QTOF-MS), including 7 new metabolites. Among them, we also discovered a previously unmentioned metabolically active site at the C1-OCH3 position. These metabolites suggested that demethylation, oxidation, glucuronidation and sulfation were major metabolic pathways. This study provided significant experiment basis for its safety estimate and valuable information about the metabolism of nuciferine, which will be advantageous for new drug development.

  2. Rapid profiling and identification of triterpenoid saponins in crude extracts from Albizia julibrissin Durazz. by ultra high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry.

    Science.gov (United States)

    Han, Lifeng; Pan, Guixiang; Wang, Yuefei; Song, Xinbo; Gao, Xiumei; Ma, Baiping; Kang, Liping

    2011-07-15

    Ultra high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry (UHPLC/ESI-Q-TOF-MS/MS) was applied to separate and identify triterpenoid saponins in crude extract from the stem bark of Albizia julibrissin Durazz. The molecular weights were determined by comparing quasi-molecular ions [M+NH(4)](+) in positive mode and [M-H](-) and [M-2H](2-) ions in negative mode. The MS/MS spectra of the [M-H](-) ions for saponins provided a wealth of structural information related to aglycone skeletons, sugar types and linked sequence. On the basis of the fragmentation behavior of known saponins isolated before, saponins from this plant were identified, even though references were not available. As a result, a total of twenty-eight saponins in the crude extract were identified, which all had a common basic skeleton of the triterpene oleanolic acid and eight of them were new compounds.

  3. Profiling genome-wide DNA methylation.

    Science.gov (United States)

    Yong, Wai-Shin; Hsu, Fei-Man; Chen, Pao-Yang

    2016-01-01

    DNA methylation is an epigenetic modification that plays an important role in regulating gene expression and therefore a broad range of biological processes and diseases. DNA methylation is tissue-specific, dynamic, sequence-context-dependent and trans-generationally heritable, and these complex patterns of methylation highlight the significance of profiling DNA methylation to answer biological questions. In this review, we surveyed major methylation assays, along with comparisons and biological examples, to provide an overview of DNA methylation profiling techniques. The advances in microarray and sequencing technologies make genome-wide profiling possible at a single-nucleotide or even a single-cell resolution. These profiling approaches vary in many aspects, such as DNA input, resolution, genomic region coverage, and bioinformatics analysis, and selecting a feasible method requires knowledge of these methods. We first introduce the biological background of DNA methylation and its pattern in plants, animals and fungi. We present an overview of major experimental approaches to profiling genome-wide DNA methylation and hydroxymethylation and then extend to the single-cell methylome. To evaluate these methods, we outline their strengths and weaknesses and perform comparisons across the different platforms. Due to the increasing need to compute high-throughput epigenomic data, we interrogate the computational pipeline for bisulfite sequencing data and also discuss the concept of identifying differentially methylated regions (DMRs). This review summarizes the experimental and computational concepts for profiling genome-wide DNA methylation, followed by biological examples. Overall, this review provides researchers useful guidance for the selection of a profiling method suited to specific research questions.

  4. Distributed user profiling via spectral methods

    Directory of Open Access Journals (Sweden)

    Dan-Cristian Tomozei

    2014-09-01

    Full Text Available User profiling is a useful primitive for constructing personalised services, such as content recommendation. In the present paper we investigate the feasibility of user profiling in a distributed setting, with no central authority and only local information exchanges between users. We compute a profile vector for each user (i.e., a low-dimensional vector that characterises her taste via spectral transformation of observed user-produced ratings for items. Our two main contributions follow: (i We consider a low-rank probabilistic model of user taste. More specifically, we consider that users and items are partitioned in a constant number of classes, such that users and items within the same class are statistically identical. We prove that without prior knowledge of the compositions of the classes, based solely on few random observed ratings (namely O(N log N such ratings for N users, we can predict user preference with high probability for unrated items by running a local vote among users with similar profile vectors. In addition, we provide empirical evaluations characterising the way in which spectral profiling performance depends on the dimension of the profile space. Such evaluations are performed on a data set of real user ratings provided by Netflix. (ii We develop distributed algorithms which provably achieve an embedding of users into a low-dimensional space, based on spectral transformation. These involve simple message passing among users, and provably converge to the desired embedding. Our method essentially relies on a novel combination of gossiping and the algorithm proposed by Oja and Karhunen.

  5. Professional Athletes' Return to Play and Performance After Operative Repair of an Achilles Tendon Rupture.

    Science.gov (United States)

    Trofa, David P; Miller, J Chance; Jang, Eugene S; Woode, Denzel R; Greisberg, Justin K; Vosseller, J Turner

    2017-06-01

    Most Achilles tendon ruptures are sports related. However, few studies have examined and compared the effect of surgical repair for complete ruptures on return to play (RTP), play time, and performance across multiple sports. To examine RTP and performance among professional athletes after Achilles tendon repair and compare pre- versus postoperative functional outcomes of professional athletes from different major leagues in the United States. Cohort study; Level of evidence, 3. National Basketball Association (NBA), National Football League (NFL), Major League Baseball (MLB), and National Hockey League (NHL) athletes who sustained a primary complete Achilles tendon rupture treated surgically between 1989 and 2013 were identified via public injury reports and press releases. Demographic information and performance-related statistics were recorded for 2 seasons before and after surgery and compared with matched controls. Statistical analyses were used to assess differences in recorded metrics. Of 86 athletes screened, 62 met inclusion criteria including 25 NBA, 32 NFL, and 5 MLB players. Nineteen (30.6%) professional athletes with an isolated Achilles tendon rupture treated surgically were unable to return to play. Among athletes who successfully returned to play, game participation averaged 75.4% ( P .05). When individual sports were compared, NBA players were most significantly affected, experiencing significant decreases in games played, play time, and performance. An Achilles tendon rupture is a devastating injury that prevents RTP for 30.6% of professional players. Athletes who do return play in fewer games, have less play time, and perform at a lower level than their preinjury status. However, these functional deficits are seen only at 1 year after surgery compared with matched controls, such that players who return to play can expect to perform at a level commensurate with uninjured controls 2 years postoperatively.

  6. Leflunomide : a manageable safety profile

    NARCIS (Netherlands)

    Riel, P.L.C.M. van; Smolen, J.S.; Emery, P.; Kalden, J.R.; Dougados, M.; Strand, C.V.; Breedveld, F.C.

    2004-01-01

    The safety profile of leflunomide in the treatment of rheumatoid arthritis has been well documented in clinical trials, postmarketing surveillance, and epidemiological studies. Both postmarketing surveillance and epidemiological study results are consistent with the safety profile of leflunomide rep

  7. Cognitive processes in criminal profile construction: a preliminary study.

    Science.gov (United States)<