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Sample records for pre-outburst fu ori

  1. The Hot Inner Disk of FU Ori

    CERN Document Server

    Zhu, Zhaohuan; Calvet, Nuria; Hernandez, Jesus; Muzerolle, James; Tannirkulam, Ajay-Kumar

    2007-01-01

    We have constructed a detailed radiative transfer disk model which reproduces the main features of the spectrum of the outbursting young stellar object FU Orionis from ~ 4000 angstrom, to ~ 8 micron. Using an estimated visual extinction Av~1.5, a steady disk model with a central star mass ~0.3 Msun and a mass accretion rate ~ 2e-4 Msun/yr, we can reproduce the spectral energy distribution of FU Ori quite well. With the mid-infrared spectrum obtained by the Infrared Spectrograph (IRS) on board the Spitzer Space Telescope, we estimate that the outer radius of the hot, rapidly accreting inner disk is ~ 1 AU using disk models truncated at this outer radius. Inclusion of radiation from a cooler irradiated outer disk might reduce the outer limit of the hot inner disk to ~ 0.5 AU. In either case, the radius is inconsistent with a pure thermal instability model for the outburst. Our radiative transfer model implies that the central disk temperature Tc > 1000 K out to ~ 0.5 - 1 AU, suggesting that the magnetorotationa...

  2. FU Ori-type outburst of 2MASS J06593158-0405277

    Science.gov (United States)

    Maehara, Hiroyuki; Kojima, Tadashi; Fujii, Mitsugu

    2014-11-01

    We report the discovery of an FU Ori-type outburst of 2MASS J06593158-0405277. The outburst was discovered by T. Kojima from the survey image obtained with a 85mm f/2.8 lens and Canon EOS 60D DSLR camera on 2014-11-03.821 UT at mag 11.0.

  3. X-ray emission from an FU Ori star in early outburst: HBC 722

    CERN Document Server

    Liebhart, Armin; Skinner, Stephen; Green, Joel

    2014-01-01

    Aims: We conducted the first X-ray observations of the newly erupting FU~Ori-type outburst in HBC~722 (V2493 Cyg) with the aim to characterize its X-ray behavior and near-stellar environment during early outburst. Methods: We used data from the \\XMM\\ and \\CXO\\ X-ray observatories to measure X-ray source temperatures and luminosities as well as the gas column densities along the line of sight toward the source. Results: We report a \\CXO\\ X-ray detection of HBC~722 with an X-ray luminosity of $L_{\\rm X}\\approx 4\\times 10^{30}~\\mathrm{ergs~s}^{-1}$. The gas column density exceeds values expected from optical extinction and standard gas-to-dust ratios. We conclude that dust-free gas masses are present around the star, such as strong winds launched from the inner disk, or massive accretion columns. A tentative detection obtained by \\XMM\\ two years earlier after an initial optical peak revealed a fainter X-ray source with only weak absorption.

  4. The past photometric history of the FU Ori-type young eruptive star 2MASS J06593158-0405277 = V960 Mon

    CERN Document Server

    Jurdana-Sepic, R

    2015-01-01

    The known FU Ori-type young eruptive stars are exceedingly rare (a dozen or so confirmed objects) and 2MASS J06593158-0405277, with its 2014 outburst, is likely the latest addition to the family. All members have displayed just one such eruption in their recorded history, an event lasting for decades. To test the FU Ori nature of 2MASS J06593158-0405277, we have reconstructed its photometric history by measuring its brightness on Harvard photographic plates spanning the time interval 1899-1989. No previous large amplitude eruption similar to that initiated in 2014 has been found, as in bona fide FU Ori-type objects. The median value of the brightness in quiescence of 2MASS J06593158-0405277 is B=15.5, with the time interval 1935-1950 characterized by a large variability (~1 mag amplitude) that contrasts with the remarkable photometric stability displayed at later epochs. The variability during 1935-1950 can either be ascribed to some T Tau like activity of 2MASS J06593158-0405277 itself or to the also young a...

  5. The large amplitude outburst of the young star HBC 722 in NGC 7000/IC 5070, a new FU Orionis candidate

    Science.gov (United States)

    Semkov, E. H.; Peneva, S. P.; Munari, U.; Milani, A.; Valisa, P.

    2010-11-01

    Context. The investigations of the photometric and spectral variability of PMS stars are essential to a better understanding of the early phases of stellar evolution. We are carrying out a photometric monitoring program of some fields of active star formation. One of our targets is the dark cloud region between the bright nebulae NGC 7000 and IC 5070. Aims: We report the discovery of a large amplitude outburst from the young star HBC 722 (LkHα 188 G4) located in the region of NGC 7000/IC 5070. On the basis of photometric and spectroscopic observations, we argue that this outburst is of the FU Orionis type. Methods: We gathered photometric and spectroscopic observations of the object both in the pre-outburst state and during a phase of increase in its brightness. The photometric BVRI data (Johnson-Cousins system) that we present were collected from April 2009 to September 2010. To facilitate transformation from instrumental measurements to the standard system, fifteen comparison stars in the field of HBC 722 were calibrated in the BVRI bands. Optical spectra of HBC 722 were obtained with the 1.3-m telescope of Skinakas Observatory (Crete, Greece) and the 0.6-m telescope of Schiaparelli Observatory in Varese (Italy). Results: The pre-outburst photometric and spectroscopic observations of HBC 722 show both low amplitude photometric variations and an emission-line spectrum typical of T Tau stars. The observed outburst started before May 2010 and reached its maximum brightness in September 2010, with a recorded ΔV ~ 4.7m amplitude. Simultaneously with the increase in brightness the color indices changed significantly and the star became appreciably bluer. The light curve of HBC 722 during the period of rise in brightness is similar to the light curves of the classical FUors - FU Ori and V1057 Cyg. The spectral observations during the time of increase in brightness showed significant changes in both the profiles and intensity of the spectral lines. Only Hα remained in

  6. Radio continuum from FU Orionis stars

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez, L.F.; Hartmann, L.W.; Chavira, E. (Universidad Nacional Autonoma de Mexico, Coyoacan (Mexico) Harvard-Smithsonian Center for Astrophysics, Cambridge, MA (USA) Instituto Nacional de Astrofisica, Optica y Electronica, Puebla (Mexico))

    1990-12-01

    Using the very large array a sensitive search is conducted for 3.6-cm continuum emission toward four FU Orionis objects: FU Ori, V1515 Cyg, V1057 Cyg, and Elias 1-12. V1057 Cyg and Elias 1-12 at the level of about 0.1 mJy is detected. The association of radio continuum emission with these FU Ori objects strengthens a possible relation between FU Ori stars and objects like L 1551 IRS 5 and Z CMa that are also sources of radio continuum emission and have been proposed as post-FU Ori objects. Whether the radio continuum emission is caused by free-free emission from ionized ejecta or if it is optically thin emission from a dusty disk is discussed. It was determined that, in the archives of the Tonantzintla Observatory, a plate taken in 1957 does not show Elias 1-12. This result significantly narrows the time range for the epoch of the outburst of this source to between 1957 and 1965. 38 refs.

  7. Accretion disc flows around FU Orionis stars

    Science.gov (United States)

    Clarke, C. J.; Lin, D. N. C.; Papaloizou, J. C. B.

    1989-01-01

    The accretion disk model of FU Orionis systems in outburst is investigated by examining the time-dependent behavior of a disk around a low-mass protostar that accretes at 0.00001-0.0001 solar masses/yr. It is found that the disk may be stabilized against the thermal ionization instability by the effect of advective heat transport and that it may therefore exist in the quasi-steady-state observed in post-outburst FU Orionis systems. The disk models are used to discuss the cosmochemical consequences of possible FU Ori events during the evolution of the primordial solar nebula.

  8. CONSTRAINING MASS RATIO AND EXTINCTION IN THE FU ORIONIS BINARY SYSTEM WITH INFRARED INTEGRAL FIELD SPECTROSCOPY

    Energy Technology Data Exchange (ETDEWEB)

    Pueyo, Laurent [Johns Hopkins University, Department of Physics and Astronomy, 366 Bloomberg Center 3400 N. Charles Street, Baltimore, MD 21218 (United States); Hillenbrand, Lynne; Hinkley, Sasha; Dekany, Richard; Roberts, Jenny [Department of Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125 (United States); Vasisht, Gautam; Roberts, Lewis C. Jr.; Shao, Mike; Burruss, Rick; Cady, Eric [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, CA 91109 (United States); Oppenheimer, Ben R.; Brenner, Douglas; Zimmerman, Neil [American Museum of Natural History, Central Park West at 79th Street, New York, NY 10024 (United States); Monnier, John D. [Department of Astronomy, University of Michigan, 941 Dennison Building, 500 Church Street, Ann Arbor, MI 48109-1090 (United States); Crepp, Justin [Department of Physics, 225 Nieuwland Science Hall, University of Notre Dame, Notre Dame, IN 46556 (United States); Parry, Ian [University of Cambridge, Institute of Astronomy, Madingley Road, Cambridge, CB3, OHA (United Kingdom); Beichman, Charles [NASA Exoplanet Science Institute, 770 South Wilson Avenue, Pasadena, CA 91225 (United States); Soummer, Remi [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States)

    2012-09-20

    We report low-resolution near-infrared spectroscopic observations of the eruptive star FU Orionis using the Integral Field Spectrograph (IFS) Project 1640 installed at the Palomar Hale telescope. This work focuses on elucidating the nature of the faint source, located 0.''5 south of FU Ori, and identified in 2003 as FU Ori S. We first use our observations in conjunction with published data to demonstrate that the two stars are indeed physically associated and form a true binary pair. We then proceed to extract J- and H-band spectro-photometry using the damped LOCI algorithm, a reduction method tailored for high contrast science with IFS. This is the first communication reporting the high accuracy of this technique, pioneered by the Project 1640 team, on a faint astronomical source. We use our low-resolution near-infrared spectrum in conjunction with 10.2 {mu}m interferometric data to constrain the infrared excess of FU Ori S. We then focus on estimating the bulk physical properties of FU Ori S. Our models lead to estimates of an object heavily reddened, A{sub V} = 8-12, with an effective temperature of {approx}4000-6500 K. Finally, we put these results in the context of the FU Ori N-S system and argue that our analysis provides evidence that FU Ori S might be the more massive component of this binary system.

  9. Fu Ori outbursts and the planet-disc mass exchange

    CERN Document Server

    Nayakshin, Sergei

    2011-01-01

    It has been recently proposed that giant protoplanets migrating inward through the disc more rapidly than they contract could be tidally disrupted when they fill their Roche lobes ~ 0.1 AU away from their parent protostars. Here we consider the process of mass and angular momentum exchange between the tidally disrupted planet and the surrounding disc in detail. We find that the planet's adiabatic mass-radius relation and its ability to open a deep gap in the disc determine whether the disruption proceeds as a sudden runaway or a balanced quasi-static process. In the latter case the planet feeds the inner disc through its Lagrangian L1 point like a secondary star in a stellar binary system. As the planet loses mass it gains specific angular momentum and normally migrates in the outward direction until the gap closes. Numerical experiments show that planet disruption outbursts are preceded by long "quiescent" periods during which the disc inward of the planet is empty. The hole in the disc is created when the p...

  10. Multi-Wavelength Study of the 2008-2009 Outburst of V1647 Ori

    CERN Document Server

    Garcia-Alvarez, D; Drake, J J; Abraham, P; Anandarao, B G; Kashyap, V; Kospal, A; Kun, M; Marengo, M; Moor, A; Peneva, S; Semkov, E; Venkat, V; Sanz-Forcada, J

    2011-01-01

    V1647 Ori is a young eruptive variable star, illuminating a reflection nebula (McNeil's Nebula). It underwent an outburst in 2003 before fading back to its pre-outburst brightness in 2006. In 2008, V1647 Ori underwent a new outburst. The observed properties of the 2003-2006 event are different in several respects from both the EXor and FUor type outbursts, and suggest that this star might represent a new class of eruptive young stars, younger and more deeply embedded than EXors, and exhibiting variations on shorter time scales than FUors. In outburst, the star lights up the otherwise invisible McNeil's nebular - a conical cloud likely accumulated from previous outbursts. We present follow-up photometric as well as optical and near-IR spectroscopy of the nebula obtainted during the 2008-2009 outburst. We will also present results from contemporaneous X-ray observations. These multi-wavelength observations of V1647 Ori, obtained at this key early stage of the outburst, provide a snapshot of the "lighting up" of...

  11. KuaFu Mission

    Institute of Scientific and Technical Information of China (English)

    XIA Lidong; TU Chuanyi; Schwenn Rainer; Donovan Eric; Marsch Eckart; WANG Jingsong; ZHANG Yongwei; XIAO Zuo

    2006-01-01

    The KuaFu mission-Space Storms, Aurora and Space Weather Explorer-is an "L1+Polar" triple satellite project composed of three spacecraft: KuaFu-A will be located at L1 and have instruments to observe solar EUV and FUV emissions, and white-light Coronal Mass Ejections (CMEs), and to measure radio waves, the local plasma and magnetic field,and high-energy particles. KuaFuB1 and KuaFu- B2 will bein polar orbits chosen to facilitate continuous 24 hours a day observation of the north polar Aurora Oval. The KuaFu mission is designed to observe the complete chain of disturbances from the solar atmosphere to geospace, including solar flares, CMEs, interplanetary clouds, shock waves, and their geo-effects, such as magnetospheric sub-storms and magnetic storms, and auroral activities. The mission may start at the next solar maximum (launch in about 2012), and with an initial mission lifetime of two to three years. KuaFu data will be used for the scientific study of space weather phenomena, and will be used for space weather monitoring and forecast purposes. The overall mission design, instrument complement, and incorporation of recent technologies will target new fundamental science, advance our understanding of the physical processes underlying space weather, and raise the standard of end-to-end monitoring of the Sun-Earth system.

  12. The large amplitude outburst of the young star HBC 722 in NGC 7000/IC 5070, a new FU Orionis candidate

    CERN Document Server

    Semkov, E; Munari, U; Milani, A; Valisa, P

    2010-01-01

    We report the discovery of a large amplitude outburst from the young star HBC 722 (LkHA 188 G4) located in the region of NGC 7000/IC 5070. On the basis of photometric and spectroscopic observations, we argue that this outburst is of the FU Orionis type. We gathered photometric and spectroscopic observations of the object both in the pre-outburst state and during a phase of increase in its brightness. The photometric BVRI data (Johnson-Cousins system) that we present were collected from April 2009 to September 2010. To facilitate transformation from instrumental measurements to the standard system, fifteen comparison stars in the field of HBC 722 were calibrated in the BVRI bands. Optical spectra of HBC 722 were obtained with the 1.3-m telescope of Skinakas Observatory (Crete, Greece) and the 0.6-m telescope of Schiaparelli Observatory in Varese (Italy). The pre-outburst photometric and spectroscopic observations of HBC 722 show both low amplitude photometric variations and an emission-line spectrum typical of...

  13. Effects of 5-FU.

    Science.gov (United States)

    Wigmore, Peter M; Mustafa, Sarah; El-Beltagy, Maha; Lyons, Laura; Umka, Jariya; Bennett, Geoff

    2010-01-01

    5-fluorouracil (5-FU) is a chemotherapeutical agent used to treat cancers including breast and colorectal. Working as an antimetabolite to prevent cell proliferation, it primarily inhibits the enzyme thymidylate synthase blocking the thymidine formation required for DNA synthesis. Although having a relatively short half-life (fog" These accounts have come primarily from patients undergoing treatment for breast cancer who report symptoms including confusion and memory impairment, which can last for months to years. Psychometric studies of patients have suffered from confounding variables, which has led to the use of rodent models to assess the cognitive effects of this drug. Researchers have used behavioral and physiological tests including the Morris water maze, novel object location/recognition tests, shock motivated T-maze, sensory gating and conditioning, to investigate the effect of this drug on cognition. The variety of cognitive tests and the difference in dosing and administration of 5-FU has led to varied results, possibly due to the different brain regions associated with each test and the subtlety of the drug's effect, but overall these studies indicates that 5-FU has a negative effect on memory, executive function and sensory gating. 5-FU has also been demonstrated to have biochemical and structural changes on specific regions of the brain. Evidence shows it can induce apoptosis and depress cell proliferation in the neurogenic regions of the adult brain including the sub granular zone (SGZ) within the hippocampus and in oligodendrocyte precursor populations within white matter tracts. Furthermore, investigations indicate levels ofdoublecortin, a marker for newly formed neurons and brain derived neurotrophic factor, a cell survival modulator, are also reduced by 5-FU in the SGZ. Thus, 5-FU appears to have a lasting negative impact on cognition and to affect cellular and biochemical markers in various brain regions. Further work is needed to understand the

  14. ORiON: Editorial Policies

    African Journals Online (AJOL)

    Papers in the following categories are typically published in ORiON: Development of New Theory, which may be useful to operations research practitioners, ... OR in Banking, applied OR modelling, applied statistical modelling, multivariate ...

  15. FuNNy

    DEFF Research Database (Denmark)

    Madsen, Per Printz

    2005-01-01

    The purpose of this paper is to describe a tool that is easy to use for implementing self learning fuzzy systems. This tool which is called FuNNy generates fuzzy systems. The tool consists of a compiler and a C learning library. The compiler translates a fuzzy system (written in a dedicated...... language, called FuNNy language) to C. The C learning library contains the learning algorithm. The generated C code is simple standard C and therefore it can be applied to all computers with a C-compiler. The learning algorithm is either a gradient descend method based on a numerical calculation...... of the gradient or a random search method. The input fuzzyfication can be described by four different kinds of membership functions. The output fuzzyfication is based on singletons. The rule base can be written in a natural language. The result of the learning is a new version of the fuzzy system described...

  16. He Manu Hou: The Transition of Māori Students into Māori Studies

    OpenAIRE

    Meegan Hall; Arama Rata; Peter Adds

    2013-01-01

    There are many known factors that can help or hinder Indigenous students undertaking tertiary study, but little is known about how Māori students experience Māori studies courses specifically. Against the backdrop of low Māori student retention in universities and the short history of Māori studies as a field of study, this article shares findings from a thematic analysis of interviews with Māori students in Māori studies. It proposes a framework, Te Ara Mātauranga, which organises new findin...

  17. Yan Fu's Thoughts of Translation

    Institute of Scientific and Technical Information of China (English)

    韩赵东

    2009-01-01

    Yan Fu was famous translator in Chinese history, and proposed three standards of translation. The theory made great contribution to Chinese translation history. However, with the development of society at present, Yah Fu's theory had been out of date. More and more translators and scholars pay more attention on linguistics to translate appropriately nowadays. It is the aim to analysis this problem in the article and introduces more detailed knowledge to make flourish translation, so that it becomes true that Chinese translation develop step by step.

  18. Enhancing Māori food security using traditional kai.

    Science.gov (United States)

    McKerchar, Christina; Bowers, Sharron; Heta, Craig; Signal, Louise; Matoe, Leonie

    2015-09-01

    Lack of food security is one of the major nutrition issues facing Māori today. Loss of traditional kai (food) gathering places and practices following colonisation and urbanisation has impacted negatively on food security for Māori. This paper explores the role of Māori in enhancing Māori food security through revitalising traditional kai. A narrative literature review of peer reviewed and grey literature on revitalising traditional kai for Māori was conducted. The focus was on two areas: increasing the availability of traditional kai to Māori households (such as through replenishing fish stocks, and gardening projects) and increasing the financial means available to Māori households to purchase food (by economic development of traditional kai industries and employment creation). A range of activities to improve food security for Māori by revitalising traditional kai was identified in the literature. Māori are now significant players in New Zealand's fishing industry, and are developing their horticultural resources. Gardening initiatives have also grown considerably in Māori communities. Enabling factors included: the return of traditional kai resources by the Crown, and successful pursuit by Māori of the legal rights to develop them; development of Māori models of governance; government policy around Māori economic development and healthy eating; and Māori leadership on the issue. Barriers to revitalising traditional kai that remain to be addressed include: tensions between Government and Māori goals and models of resource management; economic pressures resulting in severely depleted fishing stocks; and pollution of marine and freshwater fish. Revitalising traditional kai has considerable potential to improve food security for Māori, both directly in terms of food supply and by providing income, and warrants policy and practical support. These findings have implications for other indigenous cultures who are struggling to be food secure. © The

  19. Long-term orbital period behaviour of contact binaries V343 Ori and FZ Ori

    Science.gov (United States)

    Yıldırım, Muhammed Faruk; Soydugan, Faruk

    2017-02-01

    In this study, we investigated orbital period variations of two contact binaries V343 Ori and FZ Ori based on published minima times. Using the O-C analysis, it was found that both systems indicate orbital period increase. Mass transfer from less massive component to more massive component was used to explain increases in the orbital periods. On the other hand, the secular changes in their periods can be a sign of the thermal relaxation oscillation. In the O-C diagram of FZ Ori, periodic variations also exist. Cyclic periodic changes can be explained as being the result of a light-travel time effect via a tertiary body around the eclipsing pair. The minimum mass of probable tertiary component around FZ Ori was found to be 0.63 M⊙. In addition, the cyclic variation may be evidence of magnetic activity of the components, which are late-type stars.

  20. Elemental abundances of low-mass stars in the young clusters 25 Ori and lambda Ori

    CERN Document Server

    Biazzo, K; Palla, F; Briceno, C

    2011-01-01

    Aims. We aim to derive the chemical pattern of the young clusters 25 Orionis and lambda Orionis through homogeneous and accurate measurements of elemental abundances. Methods. We present FLAMES/UVES observations of a sample of 14 K-type targets in the 25 Ori and lambda Ori clusters; we measure their radial velocities, in order to confirm cluster membership. We derive stellar parameters and abundances of Fe, Na, Al, Si, Ca, Ti, and Ni using the code MOOG. Results. All the 25 Ori stars are confirmed cluster members without evidence of binarity; in lambda Ori we identify one non-member and one candidate single-lined binary star. We find an average metallicity [Fe/H]=-0.05+/-0.05 for 25 Ori, where the error is the 1sigma standard deviation from the average. lambda Ori members have a mean iron abundance value of 0.01+/-0.01. The other elements show close-to-solar ratios and no star-to-star dispersion. Conclusions. Our results, along with previous metallicity determinations in the Orion complex, evidence a small bu...

  1. Career decisions: factors that influence the Māori doctor.

    Science.gov (United States)

    Lucas, C; Edmonds, L; Leroy, J; Reith, D

    2014-06-01

    ori have known health disparities that may be addressed through increasing the cultural competency of New Zealand's medical workforce. There is a paucity of Māori health professionals choosing paediatrics or adult medicine as a career and the factors influencing their career decision are yet to be explored. First, to differentiate factors influencing the medical career choice of non-Māori paediatricians and physicians, Māori paediatricians and physicians and other Māori doctors. Second, to identify ways in which Māori doctors may be encouraged to choose paediatricians or adult medicine. A questionnaire was distributed by email to New Zealand physicians and paediatricians and to Māori doctors. Questions included demographic information, a matrix rating table and open-ended questions. Altogether 199 people accessed the questionnaire. Response rates were 9% (n = 118) for non-Māori paediatricians and physicians, 70% (n = 19) for Māori paediatricians and physicians, and 31% (n = 62) for other Māori doctors. Māori paediatricians and physicians highlighted mentoring as having significant impact on career choice. Non-Māori paediatricians and physicians regarded interest as having the most influence on career choice (P doctors (P < 0.001). All three groups regarded poor lifestyle as having the largest negative influence. No group regarded potential income as important. Mentoring provides an opportunity to attract Māori into paediatric and adult physician training. The use of existing mentoring programmes could facilitate in expanding Māori RACP workforce development. This extended Māori workforce would have benefits for the health of New Zealand as a whole. © 2014 The Authors; Internal Medicine Journal © 2014 Royal Australasian College of Physicians.

  2. The relaxing ori-ter balance of Mycoplasma genomes

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Mycoplasma are wall-less bacteria with small genomes, which are thought to have resulted from massive genome reductive processes, during which the ori-ter balance may be disrupted. For technical difficulties, ori and ter have been located only in a few Mycoplasma strains. Using the Z curve method, we were able to locate turning points on the Mycoplasma genomes, with the minimum and maximum points co-locating with ori or ter in the reference genomes. Assuming Z curve correctly located ori and ter, we calculated the distances from ori to ter in both directions on the circular genome and calculated the ori-ter balance status. The Mycoplasma genomes were not balanced, possibly as a result of close association of Mycoplasma with hosts, where there would be no other microbes for Mycoplasma to compete with for nutrients, so fastest possible growth related to balanced genomes might not be needed by Mycoplasma, leading to a relaxing ori-ter balance.

  3. Congenital Unilateral Hypoplasia of Depressor Anguli Oris

    Directory of Open Access Journals (Sweden)

    Seckin O. Ulualp

    2012-01-01

    Full Text Available Objectives. Asymmetric facial appearance may originate from abnormalities of facial musculature or facial innervation. We describe clinical features of congenital hypoplasia of depressor anguli oris muscle in a child. Material and Methods. Chart of a 10-month-old female referred to a tertiary care pediatric hospital for assessment of facial paralysis was reviewed. Data included relevant history and physical examination, diagnostic work up, and management. Results. The child presented with asymmetric movement of lower lip since birth. Asymmetry of lower lip was more pronounced when she smiled and cried. Rest of the face movement was symmetric. On examination, the face appeared symmetric at rest. The child had inward deviation of right lower lip when she smiled. Facial nerve function, as determined by frowning/forehead, wrinkling, eye closure, nasolabial fold depth, and tearing, was symmetric. Magnetic resonance imaging of the temporal bones and internal auditory canals were within normal limits. Echocardiogram did not show cardiac abnormality. Auditory brainstem response showed no abnormality. Conclusions. Congenital hypoplasia of depressor anguli oris is a rare anomaly that causes asymmetric crying face. Pediatricians and otolaryngologists need to be cognizant of cardiac, head and neck, and central nervous system anomalies associated with congenital unilateral hypoplasia of depressor anguli oris.

  4. 5-FU Metabolism in Cancer and Orally-Administrable 5-FU Drugs

    Directory of Open Access Journals (Sweden)

    Iwao Sasaki

    2010-09-01

    Full Text Available 5-Fluorouracil (5-FU is a key anticancer drug that for its broad antitumor activity, as well as for its synergism with other anticancer drugs, has been used to treat various types of malignancies. In chemotherapeutic regimens, 5-FU has been combined with oxaliplatin, irinotecan and other drugs as a continuous intravenous infusion. Recent clinical chemotherapy studies have shown that several of the regimens with oral 5-FU drugs are not inferior compared to those involving continuous 5-FU infusion chemotherapy, and it is probable that in some regimens continuous 5-FU infusion can be replaced by oral 5-FU drugs. Historically, both the pharmaceutical industry and academia in Japan have been involved in the development of oral 5-FU drugs, and this review will focus on the current knowledge of 5-FU anabolism and catabolism, and the available information about the various orally-administrable 5-FU drugs, including UFT, S-1 and capecitabine. Clinical studies comparing the efficacy and adverse events of S-1 and capecitabine have been reported, and the accumulated results should be utilized to optimize the treatment of cancer patients. On the other hand, it is essential to elucidate the pharmacokinetic mechanism of each of the newly-developed drugs, to correctly select the drugs for each patient in the clinical setting, and to further develop optimized drug derivatives.

  5. AN ANALYSIS OF THE ENVIRONMENTS OF FU ORIONIS OBJECTS WITH HERSCHEL

    Energy Technology Data Exchange (ETDEWEB)

    Green, Joel D.; Evans, Neal J. II; Merello, Manuel [Department of Astronomy, The University of Texas at Austin, 2515 Speedway, Stop C1400, Austin, TX 78712-1205 (United States); Kospal, Agnes [European Space Agency (ESA/ESTEC), Keplerlaan 1, 2200-AG Noordwijk (Netherlands); Herczeg, Gregory [Kavli Institute for Astronomy and Astrophysics, Peking University, Beijing 100871 (China); Quanz, Sascha P. [Institute for Astronomy, ETH Zurich, Wolfgang-Pauli-Strasse 27, CH-8093 Zurich (Switzerland); Henning, Thomas; Bouwman, Jeroen [Max Planck Institute for Astronomy, Koenigstuhl 17, D-69117 Heidelberg (Germany); Van Kempen, Tim A. [Leiden Observatory, Leiden University, P.O. Box 9513, 2300-RA Leiden (Netherlands); Lee, Jeong-Eun [Department of Astronomy and Space Science, Kyung Hee University, Gyeonggi 446-701 (Korea, Republic of); Dunham, Michael M. [Department of Astronomy, Yale University, New Haven, CT (United States); Meeus, Gwendolyn [Departamento de Fisica Teorica, Universidad Autonoma de Madrid, Campus Cantoblanco (Spain); Chen, Jo-hsin [Jet Propulsion Laboratory, Pasadena, CA (United States); Guedel, Manuel; Liebhart, Armin [Department of Astrophysics, University of Vienna (Austria); Skinner, Stephen L., E-mail: joel@astro.as.utexas.edu [Center for Astrophysics and Space Astronomy (CASA), University of Colorado, Boulder, CO 80309-0389 (United States)

    2013-08-01

    We present Herschel-HIFI, SPIRE, and PACS 50-670 {mu}m imaging and spectroscopy of six FU Orionis-type objects and candidates (FU Orionis, V1735 Cyg, V1515 Cyg, V1057 Cyg, V1331 Cyg, and HBC 722), ranging in outburst date from 1936 to 2010, from the 'FOOSH' (FU Orionis Objects Surveyed with Herschel) program, as well as ancillary results from Spitzer Infrared Spectrograph and the Caltech Submillimeter Observatory. In their system properties (L{sub bol}, T{sub bol}, and line emission), we find that FUors are in a variety of evolutionary states. Additionally, some FUors have features of both Class I and II sources: warm continuum consistent with Class II sources, but rotational line emission typical of Class I, far higher than Class II sources of similar mass/luminosity. Combining several classification techniques, we find an evolutionary sequence consistent with previous mid-IR indicators. We detect [O I] in every source at luminosities consistent with Class 0/I protostars, much greater than in Class II disks. We detect transitions of {sup 13}CO (J{sub up} of 5-8) around two sources (V1735 Cyg and HBC 722) but attribute them to nearby protostars. Of the remaining sources, three (FU Ori, V1515 Cyg, and V1331 Cyg) exhibit only low-lying CO, but one (V1057 Cyg) shows CO up to J = 23 {yields} 22 and evidence for H{sub 2}O and OH emission, at strengths typical of protostars rather than T Tauri stars. Rotational temperatures for 'cool' CO components range from 20 to 81 K, for {approx} 10{sup 50} total CO molecules. We detect [C I] and [N II] primarily as diffuse emission.

  6. Cancrum oris and noma: some etymological and historical remarks.

    Science.gov (United States)

    Marck, K W

    2003-09-01

    Necrotising ulcerative stomatitis is used in the International Statistical Classification of the WHO for orofacial gangrene in children, that is known in medical literature as cancrum oris or noma. The many historical synonyms for this disease together with other historical data indicate that orofacial gangrene in children was a common affection in Europe in previous centuries. The etymological and historical backgrounds of the names "noma" and "cancrum oris" indicate that "cancrum oris" is based on the incorrect use of the Latin term "cancer oris" and maybe on tradition, for which reasons the use of "noma" as medical term for necrotising ulcerative stomatitis should be preferred.

  7. Ori-Finder: A web-based system for finding oriCs in unannotated bacterial genomes

    Directory of Open Access Journals (Sweden)

    Zhang Chun-Ting

    2008-02-01

    Full Text Available Abstract Background Chromosomal replication is the central event in the bacterial cell cycle. Identification of replication origins (oriCs is necessary for almost all newly sequenced bacterial genomes. Given the increasing pace of genome sequencing, the current available software for predicting oriCs, however, still leaves much to be desired. Therefore, the increasing availability of genome sequences calls for improved software to identify oriCs in newly sequenced and unannotated bacterial genomes. Results We have developed Ori-Finder, an online system for finding oriCs in bacterial genomes based on an integrated method comprising the analysis of base composition asymmetry using the Z-curve method, distribution of DnaA boxes, and the occurrence of genes frequently close to oriCs. The program can also deal with unannotated genome sequences by integrating the gene-finding program ZCURVE 1.02. Output of the predicted results is exported to an HTML report, which offers convenient views on the results in both graphical and tabular formats. Conclusion A web-based system to predict replication origins of bacterial genomes has been presented here. Based on this system, oriC regions have been predicted for the bacterial genomes available in GenBank currently. It is hoped that Ori-Finder will become a useful tool for the identification and analysis of oriCs in both bacterial and archaeal genomes.

  8. Characterization ofgari andfu-fu preparation procedures in Nigeria.

    Science.gov (United States)

    Westby, A; Twiddy, D R

    1992-03-01

    Processes for the production ofgari, East Nigerianfu-fu and West Nigerianfu-fu are described. Changes in pH value, moisture content, microflora and sugar content of cassava duringgari andfu-fu preparation are reported. Mannitol accumulated during thegari fermentation but not in either of thefu-fu fermentations. During each stage ofgari andfu-fu production, lactic acid bacteria predominated. Homofermentative organisms occurred most frequently in the early stages of each process and heterofermenters in the latter ones. Of the 179 microorganisms that were isolated and characterized fromgari andfu-fu, 52% were able to hydrolyse linamarin and 14% starch.

  9. Oxygen Reserve Index (ORI): Validation of a new variable

    NARCIS (Netherlands)

    Scheeren, T.W.L.; Spanjersberg, R.; Struys, M.M.R.F.

    2016-01-01

    Conclusion: In the flat part of the haemoglobin-oxygen binding curve, where oxygen saturation is >97%, a decrease in ORI indicates a falling PaO2 prior to oxygen desaturation. As such, the non-invasive and continuously available ORI may offer additional information at maximum SpO2 values and help gu

  10. Synthesis and characterization of HPMA copolymer-5-FU conjugates

    Institute of Scientific and Technical Information of China (English)

    Fang Yuan; Fu Chen; Qing Yu Xiang; Xuan Qin; Zhi Rong Zhang; Yuan Huang

    2008-01-01

    N-(2-Hydroxypropyl)methacrylamide copolymer-5-fluorouracil (PHPMA-FU)conjugates were synthesized by a novel and simplified synthetic mute,and characterized by UV,FTIR and HPLC analyses.The conjugated content of 5-fluorouracil (5-FU)was 3.41 ± 0.07 wt%.The stabilities of PHPMA-FU conjugates under different conditions were studied.The results showed that HPMA copolymer was a potential carrier for tumor-targeting delivery of 5-FU.

  11. DS/EN 1520 FU:2015

    DEFF Research Database (Denmark)

    Goltermann, Per; Cornelius, Thomas

    DS/EN 1520 FU er en sammenskrivning af de væsentligste afsnit af standarden med tilhørende dansk anneks, hvor de danske værdier er angivet. Sammenskrivningen gør det lettere for den projekterende at beregne de fleste konstruktioner efter DS/EN 1520-systemet. En konstruktion, der opfylder kravene i...... DS/EN 1520 FU, vil også tilfredsstille de tilsvarende krav i DS/EN 1520. DS/INF 168, Supplerende vejledning ved brug af EN 1520, Præfabrikerede armerede elementer af letbeton med lette tilslag og åben struktur er også en del af sammenskrivningen. Denne udgave er også opdateret med seneste nationale...

  12. KuaFu Mission: The scientific payload of KuaFu-B

    Science.gov (United States)

    Wang, J.-S.; Tu, C.-Y.; Schwenn, R.; Donovan, E.; Xia, L.-D.; Zhang, Y.-W.; Kuafu Team

    The KuaFu mission would consist an L1 satellite KuaFu-A and a polar satellite pair KuaFu B1 B2 The mission is designed to explore the whole cause-and-result chain in solar-terrestrial space The two KuaFu-Bs will have the same payload sets and fly on the same polar orbit plane but with a phase difference of half period The preferred perigee is 1 8 Re and the apogee is 7 Re This orbit design will support a 24 times 7 full-covered observation on the northern auroral oval by the onboard aurora cameras The suggested payloads consist of a Far Ultraviolet Auroral Monitoring Camera UVAMC a FUV Imaging Spectrometer FUVSI a Wide Field Auroral Imager WFAI a Fluxgate Magnetometer FGM a High Energy Charged Particle Experiment HECPE an Imaging energetic electron and proton instrument IEPS a Neutral Atom Imager on KuaFu NAIK a Fast Plasma Pitch Angle Instrument FPI an Ion Mass Spectrometer IMS FPI and IMS were suggested to merge and a Tri-Band Beacon TBB

  13. Possible Reasons for the Slow Rotation of BF Ori

    Science.gov (United States)

    Shulman, S. G.

    2016-03-01

    Possible reasons for the very low projected rotation velocity of BF Ori compared to other UX Ori stars are discussed. The hypothesis of a close companion that slows down the star's rotation by a tidal interaction is examined. Based on a theory of synchronization and modern models of evolution, the interaction is calculated numerically for different masses of the companion and values of the semi-major axis. It is shown that in order to obtain the projected velocity observed for BF Ori, the companion must have a mass greater than 0.5M⊙ . Such a large companion should have been discovered observationally. It is suggested that the low rotation velocity of BF Ori is more likely to be related to the distribution of the angular momentum of a protostellar cloud between the angular momentum of the star and the orbital angular momentum of a low-mass companion.

  14. ANALOGIES ENTRE LA THÉORIE STOCHASTIQUE ET LA THÉORIE QUANTIQUE

    Directory of Open Access Journals (Sweden)

    I BENDAHMANE

    2011-12-01

    Full Text Available Des analogies ont été faites entre la théorie quantique et la théorie stochastique qui décrivent des modèles d’évolution complètement différents dans des statuts mathématiques semblables ; Les processus stochastiques markoviens permettent une description acceptable des problèmes de la physique quantique. L’équation quantique de Schrödinger et l’équation stochastique de Chapman-Kolmogorov ont la même forme différentielle et peuvent par conséquent partager les mêmes solutions. Un lien profond existe entre l’intégrale de chemin de Feynman et l’intégrale de chemin stochastique de Wiener. Néanmoins, l’expression du propagateur de Wiener est mieux définie ; la constante de proportionnalité imposée par Feynman en raison de la normalisation a été naturellement déduite dans l’intégrale de chemin de Wiener. Ce résultat constitue la contribution originale de ce travail.

  15. The FU gene and its possible protein isoforms

    Directory of Open Access Journals (Sweden)

    Nöthen Markus M

    2004-07-01

    Full Text Available Abstract Background FU is the human homologue of the Drosophila gene fused whose product fused is a positive regulator of the transcription factor Cubitus interruptus (Ci. Thus, FU may act as a regulator of the human counterparts of Ci, the GLI transcription factors. Since Ci and GLI are targets of Hedgehog signaling in development and morphogenesis, it is expected that FU plays an important role in Sonic, Desert and/or Indian Hedgehog induced cellular signaling. Results The FU gene was identified on chromosome 2q35 at 217.56 Mb and its exon-intron organization determined. The human developmental disorder Syndactyly type 1 (SD1 maps to this region on chromosome 2 and the FU coding region was sequenced using genomic DNA from an affected individual in a linked family. While no FU mutations were found, three single nucleotide polymorphisms were identified. The expression pattern of FU was thoroughly investigated and all examined tissues express FU. It is also clear that different tissues express transcripts of different sizes and some tissues express more than one transcript. By means of nested PCR of specific regions in RT/PCR generated cDNA, it was possible to verify two alternative splicing events. This also suggests the existence of at least two additional protein isoforms besides the FU protein that has previously been described. This long FU and a much shorter isoform were compared for the ability to regulate GLI1 and GLI2. None of the FU isoforms showed any effects on GLI1 induced transcription but the long form can enhance GLI2 activity. Apparently FU did not have any effect on SUFU induced inhibition of GLI. Conclusions The FU gene and its genomic structure was identified. FU is a candidate gene for SD1, but we have not identified a pathogenic mutation in the FU coding region in a family with SD1. The sequence information and expression analyses show that transcripts of different sizes are expressed and subjected to alternative splicing

  16. White light-mediated Cu (II)-5FU interaction augments the chemotherapeutic potential of 5-FU: an in vitro study.

    Science.gov (United States)

    Chibber, Sandesh; Farhan, Mohd; Hassan, Iftekhar; Naseem, Imrana

    2011-10-01

    5-Fluorouracil (5-FU) is a potent photosensitizer used in colon and rectal cancers. 5-FU on galvanostatic electrolysis or radiation-induced oxidation of aqueous solution yields N(1)-C(5)-linked dimmer hydrate of 5-FU. Copper is presently associated with chromatin; in cancer cells the concentration of copper is very high. It has been shown to be capable of mediating the action of several anticancer drugs through the production of reactive oxygen species (ROS). The objective of the present study is to determine the Cu (II)-mediated anticancer mechanism of 5-FU under photo-illumination as well as 5-FU alone. We have shown that a pro-oxidant action was enhanced when Cu (II) was used with 5-FU as compared to 5-FU alone. This may be due to the inhibition of dimerization of 5-FU when present in combination with Cu (II) under photo-illumination. It was also shown that 5-FU alone as well as in combination with Cu (II) was able to generate oxidative stress in lymphocyte which is inhibited by scavengers of ROS. Moreover, the results of Fourier-transformed infrared spectra lead to the conclusion that the dimerization of 5-FU was inhibited when used in combination with Cu (II). It was due to the interaction of 5-FU with Cu (II). Hence, we propose that during chemoradiotherapy with 5-FU, the endogenous copper is mobilized by 5-FU, leading to the generation of ROS which cause oxidative stress and possibly cancer cell death by apoptosis.

  17. X-ray in Zeta-Ori

    Science.gov (United States)

    López-García, M. A.; López-Santiago, J. L.; Albacete-Colombo, J. F.; De Castro, E.

    2013-05-01

    Nearby star-forming regions are ideal laboratories to study high-energy emission processes but they usually present high absorption what makes difficult to detect the stellar population inside the molecular complex. As young late-type stars show high X-ray emission and X-ray photons are little absorbed by interstellar material, X-ray dedicated surveys are an excellent tool to detect the low-mass stellar population in optically absorbed regions. In this work, we present a study of the star-forming region Zeta-Ori and its surroundings. We combine optical, infrared and X-ray data. Properties of the X-ray emiting plasma and infrared features of the young stellar objects detected in the XMM-Newton observation are determined. The southern part of the Orion B giant molecular cloud complex harbor other star forming regions, as NGC 2023 and NGC 2024, we use this regions to compare. We study the spectral energy distribution of X-ray sources. Combining these results with infrared, the X-ray sources are classified as class I, class II and class III objects. The X-ray spectrum and ligth curve of detected X-ray sources is analyzed to found flares. We use a extincion-independent index to select the stars with circumstellar disk, and study the relationship between the present of disk and the flare energy. The results are similar to others studies and we conclude that the coronal properties of class II and class III objects in this region do not differ significantly from each other and from stars of similar infrared class in the ONC.

  18. GW Ori: Inner disk readjustments in a triple system

    CERN Document Server

    Fang, M; Roccatagliata, V; Fedele, D; Henning, Th; Eiroa, C; Müller, A

    2014-01-01

    (abridged) We study the young stellar system GW Ori, concentrating on its accretion/wind activity by using our high-resolution optical spectra and $U$-band photometry. We also characterize the disk properties of GW Ori by modeling its spectral energy distribution (SED). By comparing our data to the synthetical spectra, we classify GW Ori as a G8 star. Based on the RVs derived from the spectra, we confirm the previous result as a close companion in GW Ori with a period of ~242 days and an orbital semi-major axis of ~1 AU. The RV residuals after the subtraction of the orbital solution with the equivalent widths of accretion-related emission lines vary with periods of 5-6.7 days during short time intervals, which are caused by the rotational modulation. The H$\\alpha$ and H$\\beta$ line profiles of GW Ori can be decomposed in two central-peaked emission components and one blue-shifted absorption component. The absorption components are due to a disk wind modulated by the orbital motion of the close companion. Ther...

  19. ORIS: the Oak Ridge Imaging System operation's manual

    Energy Technology Data Exchange (ETDEWEB)

    Bell, P. R.; Dillon, R. S.

    1977-12-01

    The Oak Ridge Imaging System (ORIS) programs are briefly described. This volume is intended as an operators manual, but it includes program abstracts and instructions for assembling the modules and adding new ones. The instructions are specifically for the RK8E version, but they apply with minor changes to versions for other OS/8 devices. The system provides for access, storage, processing, and display of nuclear medicine images and for any other type of data displayable in image form. The system is not limited to square image arrays or to any specific size of data arrays below 16K elements. The complete code package for ORIS is available as MED-8/ORIS from the Biomedical Computing Technology Information Center (BCTIC), Oak Ridge National Laboratory.

  20. Some Thoughts on the English Version of "Fu Wa"

    Institute of Scientific and Technical Information of China (English)

    易高燕

    2009-01-01

    There have been many disputes about the translation of the Beijing 2008 Olympiad Mascots since it was first announced in 2005.And it was at last translated directly as the Chinese phonetic alphabet " Fu Wa".So this essay is going to explore some ideas of the English translation of "Fu Wa",and meanwhile discuss some translation approaches of culture-loaded words.

  1. A Simple Calculation in Service of Constraining the Rate of FU Orionis Outburst Events from Photometric Monitoring Surveys

    CERN Document Server

    Hillenbrand, Lynne A

    2015-01-01

    An enigmatic and rare type of young stellar object is the FU Orionis class. The members are interpreted as "outbursting," that is, currently in a state of enhanced accretion by several orders of magnitude relative to the more modest disk-to-star accretion rates measured in typical T Tauri stars. They are key to our understanding of the history of stellar mass assembly and pre-main sequence evolution, as well as critical to consider in the chemical and physical evolution of the circumstellar environment -- where planets form. A common supposition is that *all* T Tauri stars undergo repeated such outbursts, more frequently in their earlier evolutionary stages when the disks are more massive, so as to build up the requisite amount of stellar mass on the required time scale. However, the actual data supporting this traditional picture of episodically enhanced disk accretion are limited, and the observational properties of the known sample of FU Ori objects quite diverse. To improve our understanding of these rare...

  2. Possibility of the BF Ori rotation slowdown due to the orbital synchronization

    Science.gov (United States)

    Shulman, S. G.

    2016-11-01

    BF Ori is an UX Ori type star with a very slow projected rotational velocity. We analyzed a possibility of the slowdown due to the synchronization in close binary systems. We hypothesized that BF Ori has a companion and estimated its properties as it might be massive and close enough to make this slowdown possible. The conclusion that the rotational velocity of BF Ori is apparently not a result of the tidal interaction with a low mass companion is made.

  3. L'électron magnétique (théorie de Dirac)

    CERN Document Server

    Broglie, Louis de

    1934-01-01

    Succès et échecs des théories quantiques et de la mécanique ondulatoire primitive ; la théorie de l'électron magnétique et tournant de Dirac, principes généraux ; applications de la théorie de Dirac, critiques et compléments divers.

  4. The Herbig Be Star V1818 Ori and Its Environment

    Science.gov (United States)

    Chiang, Hsin-Fang; Reipurth, Bo; Hillenbrand, Lynne

    2015-03-01

    The little-studied Herbig Be star V1818 Ori is located in the direction of the southern L1641 cloud and the Mon R2 star-forming complex, and is most likely associated with the latter at a distance of ˜900 pc. A high-resolution spectrum is consistent with a spectral type around B7 V, with lines of Hα, the red Ca ii triplet, and several forbidden lines in emission. An All Sky Automated Survey V-band light curve spanning 9 yr reveals major variability with deep absorption episodes reminiscent of the UX Orionis stars. We have searched for additional young stars clustering around V1818 Ori using grism images and the 2MASS and Wide-field Infrared Survey Explorer catalogs, and have found almost two dozen fainter stars with evidence of youth. Direct images show that the bright star IRAS 05510-1025, only about 3 arcmin from V1818 Ori, is surrounded by a reflection nebula, indicating its association with a molecular cloud. A spectrum of the star shows no emission-lines, and it is found to be a close binary with late B and early G type components. Its radial velocity indicates that it is an interloper, accidentally passing through the cloud and not physically associated with V1818 Ori.

  5. Main-Seqence Fitting Distance to the sigma Ori Cluster

    CERN Document Server

    Sherry, W H; Wolk, S J; Adams, N R

    2008-01-01

    The sigma Ori cluster is an unbound aggregate of a few hundred young, low-mass stars centered on the multiple system sigma Ori. This cluster is of great interest because it is at an age when roughly half of the stars have lost their protoplanetary disks, and the cluster has a very large population of brown dwarfs. One of the largest sources of uncertainty in the properties of the cluster is that the distance is not well known. The directly measured Hipparcos distance to sigma Ori AB is 350 (+120,-90) pc. On the other hand, the distance to the Orion OB1b subgroup (of which sigma Ori is thought to be a member), 473+/-40 pc, is far better determined, but it is an indirect estimate of the cluster's distance. Also, Orion OB1b may have a depth of 40 pc along our line of sight. We use main sequence fitting to 9 main sequence cluster members to estimate a best fit distance of 420+/-30 pc, assuming a metallicity of -0.16+/-0.11 or 444 pc assuming solar metallicity. A distance as close as 350 pc is inconsistent with th...

  6. Masses of the astrometric SB2 \\zeta Ori A

    CERN Document Server

    Rivinius, Th; Stahl, O

    2010-01-01

    We report the first dynamic mass for an O-type supergiant, the interferometrically resolved SB2 system \\zeta Ori A (O9.5Ib+B0/1). The separation of the system excludes any previous mass-transfer, ensuring that the derived masses can be compared to single star evolutionary tracks.

  7. S Ori 70: Just a Foreground Field Brown Dwarf?

    CERN Document Server

    Burgasser, A J; McGovern, M R; McLean, I S; Prato, L; Reid, I N; Burgasser, Adam J.; Govern, Mark R. Mc; Lean, Ian S. Mc

    2004-01-01

    We examine recent claims that the T-type brown dwarf S Ori 053810.1-203626 (S Ori 70) is a spectroscopically verified low mass (3$^{+5}_{-1}$ M$_{Jup}$) member of the 1--8 Myr $\\sigma$ Orionis cluster. Comparative arguments by Mart{\\'{i}}n & Zapatero Osorio asserting that S Ori 70 exhibits low surface gravity spectral features indicative of youth and low mass are invalidated by the fact that their comparison object was not the field T dwarf 2MASS 0559$-$1404 but rather a nearby background star. Instead, we find that the 1--2.5 $\\micron$ spectra of S Ori 70 are well-matched to older (age $\\sim$ few Gyr) field T6--T7 dwarfs. Moreover, we find that spectral model fits to late-type field T dwarf spectra tend to yield low surface gravities ($\\log{g}$ = 3.0--3.5), and thus young ages ($\\lesssim$ 5 Myr) and low masses ($\\lesssim$ 3 M$_{Jup}$), inconsistent with expected and/or empirical values. Finally, we show that the identification of one T dwarf in the field imaged by Zapatero Osorio et al. is statistically ...

  8. THE HERBIG BE STAR V1818 ORI AND ITS ENVIRONMENT

    Energy Technology Data Exchange (ETDEWEB)

    Chiang, Hsin-Fang; Reipurth, Bo [Institute for Astronomy and NASA Astrobiology Institute, University of Hawaii at Manoa, 640 North Aohoku Place, Hilo, HI 96720 (United States); Hillenbrand, Lynne, E-mail: hchiang@ifa.hawaii.edu, E-mail: reipurth@ifa.hawaii.edu [Department of Astronomy, California Institute of Technology, Pasadena, CA 91125 (United States)

    2015-03-15

    The little-studied Herbig Be star V1818 Ori is located in the direction of the southern L1641 cloud and the Mon R2 star-forming complex, and is most likely associated with the latter at a distance of ∼900 pc. A high-resolution spectrum is consistent with a spectral type around B7 V, with lines of Hα, the red Ca ii triplet, and several forbidden lines in emission. An All Sky Automated Survey V-band light curve spanning 9 yr reveals major variability with deep absorption episodes reminiscent of the UX Orionis stars. We have searched for additional young stars clustering around V1818 Ori using grism images and the 2MASS and Wide-field Infrared Survey Explorer catalogs, and have found almost two dozen fainter stars with evidence of youth. Direct images show that the bright star IRAS 05510–1025, only about 3 arcmin from V1818 Ori, is surrounded by a reflection nebula, indicating its association with a molecular cloud. A spectrum of the star shows no emission-lines, and it is found to be a close binary with late B and early G type components. Its radial velocity indicates that it is an interloper, accidentally passing through the cloud and not physically associated with V1818 Ori.

  9. Varicella-zoster virus (VZV) origin of DNA replication oriS influences origin-dependent DNA replication and flanking gene transcription.

    Science.gov (United States)

    Khalil, Mohamed I; Sommer, Marvin H; Hay, John; Ruyechan, William T; Arvin, Ann M

    2015-07-01

    The VZV genome has two origins of DNA replication (oriS), each of which consists of an AT-rich sequence and three origin binding protein (OBP) sites called Box A, C and B. In these experiments, the mutation in the core sequence CGC of the Box A and C not only inhibited DNA replication but also inhibited both ORF62 and ORF63 expression in reporter gene assays. In contrast the Box B mutation did not influence DNA replication or flanking gene transcription. These results suggest that efficient DNA replication enhances ORF62 and ORF63 transcription. Recombinant viruses carrying these mutations in both sites and one with a deletion of the whole oriS were constructed. Surprisingly, the recombinant virus lacking both copies of oriS retained the capacity to replicate in melanoma and HELF cells suggesting that VZV has another origin of DNA replication.

  10. Antiques in the Alley: Guan Fu Classical Art Museum

    Institute of Scientific and Technical Information of China (English)

    ZhangJing

    2003-01-01

    Nestled in an alley off South Chaoyangmen Nei Street in Beijing is Guan Fu Classical Art Museum, China's first privately owned and operated antique museum run by one of the country's most ardent collectors,

  11. Antiques in the Alley:Guan fu Classical Art Museum

    Institute of Scientific and Technical Information of China (English)

    Zhangjing

    2003-01-01

    Nestled in an alley off South chaoyang men nei street in beijing is guan fu classical art museum,china's first privately owned and operated antique museum run by one of the country's most ardent collectors.

  12. Navigation: process of building relationships with kaumātua (Māori leaders).

    Science.gov (United States)

    Dyall, Lorna; Skipper, Te Kaanga; Kēpa, Mere; Hayman, Karen; Kerse, Ngaire

    2013-01-25

    In the article the authors depict relations in sociocultural navigation by Māori researchers conducting research embedded in mutual trust; rather than instrumental navigation in linear time. A longitudinal study of Māori and non Māori men and women ageing successfully was planned; this feasibility stage tested whether engaging with kōroua/older Māori men and kuia/older Māori women was possible. We document the process undertaken with Ngā Pae o te Maramatanga New Zealand's Indigenous Centre of Research Excellence (hosted by the University of Auckland) to involve Māori people in the research, engaging with kōroua and kuia aged 75 to 79 years old, developing focus groups to discuss questions specific to te reo Māori me ngā tikanga/Maori language and culture, and building research capacity in Māori tribal and primary health organisations in the Bay of Plenty. In addition, engaging with Te Taura Whiri i te Reo Māori/ Māori Language Commission to translate the questions; recruiting the RopuKaitiaki o Ngā Tikanga Māori/Protectors of Principles of Conduct in Māori Research, and naming the study will be discussed. The involvement of the kaumātua/older Māori people has been fundamental in laying the foundation of the Life and Living in Advanced Age: A Cohort Study in New Zealand (LiLACS NZ), Te Puāwaitanga o Ngā Tapuwae Kia Ora Tonu to study a group of Māori aged 80 to 90 years old.

  13. Health benefits of Kung Fu: a systematic review.

    Science.gov (United States)

    Tsang, Tracey Wai Man; Kohn, Michael; Chow, Chin Moi; Singh, Maria Fiatarone

    2008-10-01

    The Chinese martial arts (Kung Fu) have existed for centuries and are generally accepted as being beneficial for health without much empirical data. The aim of this systematic review was to assess the health effects of "hard" Kung Fu styles by performing electronic and manual searches of the literature. The aspects of health and the Kung Fu style examined varied between most studies; in some cases, the martial art group consisted of practitioners of other martial art styles also. Of 2103 references identified, only nine papers were eligible and reviewed. All were observational studies, observing a range of health aspects possibly related to Kung Fu training or performance. Our findings suggest that there is no evidence that Kung Fu practice is associated with the prevention or treatment of any health condition. However, as a moderate- to high-intensity form of aerobic exercise, it may confer benefits similar to those attributed to other aerobic training modalities. However, this hypothesis remains to be tested in clinical trials. Physiological benefits (e.g., aerobic capacity and bone density) may be associated with long-term Kung Fu practice. Future research in this area should adopt experimental designs, clearly identifying eligibility criteria, testing and training protocols, and include health-related outcomes and documentation of adverse events, to advance knowledge in this field.

  14. 5-FU-induced peripheral neuropathy: a rare complication of a well-known drug.

    NARCIS (Netherlands)

    Laarhoven, H.W.M. van; Verstappen, C.C.P.; Beex, L.V.A.M.; Kappelle, A.C.; Punt, C.J.A.

    2003-01-01

    Peripheral neuropathy is a rare complication of the commonly used cytotoxic drug 5-fluorouracil (5-FU). We report a case of 5-FU-induced peripheral neuropathy in a patient with metastatic colorectal carcinoma. Discontinuation of 5-FU therapy is recommended in case of 5-FU-related neurotoxicity.

  15. Oak Ridge Graph Analytics for Medical Innovation (ORiGAMI)

    Energy Technology Data Exchange (ETDEWEB)

    2016-01-01

    In this era of data-driven decisions and discovery where Big Data is producing Bigger Data, data scientists at the Oak Ridge National Laboratory are leveraging unique leadership infrastructure (e.g., Urika XA and Urika GD appliances) to develop scalable algorithms for semantic, logical and statistical reasoning with Big Data (i.e., data stored in databases as well as unstructured data in documents). ORiGAMI is a next-generation knowledge-discovery framework that is: (a) knowledge nurturing (i.e., evolves seamlessly with newer knowledge and data), (b) smart and curious (i.e. using information-foraging and reasoning algorithms to digest content) and (c) synergistic (i.e., interfaces computers with what they do best to help subject-matter-experts do their best. ORiGAMI has been demonstrated using the National Library of Medicine's SEMANTIC MEDLINE (archive of medical knowledge since 1994).

  16. Report of an infant with noma (cancrum oris).

    Science.gov (United States)

    Yuca, Köksal; Yuca, Sevil Ari; Cankaya, Hakan; Caksen, Hüseyin; Calka, Omer; Kiriş, Muzaffer

    2004-06-01

    Noma (cancrum oris) is an infectious disease that destroys the oro-facial tissues and other neighboring structures in its fulminating course. The starting point of the disease is acute ulcero-necrotic gingivitis, which results in an extensive gangrenous plaque destroying all of the soft tissues of the face. It predominantly affects children aged 2-16 years and is primarily seen in areas where the socioeconomic standards are low and there is poor hygiene, as in developing countries. We discuss possible predisposing factors in cancrum oris such as malnutrition, infectious diseases, HIV infection, and immune compromise conditions. Poverty is the most important risk factor. We report the case of a 6-month-old child with noma and review the characteristic features of this disease.

  17. Prestellar and protostellar cores in Ori B9

    CERN Document Server

    Miettinen, O; Haikala, L K; Kainulainen, J; Johansson, L E B

    2009-01-01

    The aims of this study are to determine the properties and spatial distribution of dense cores in Ori B9, and to estimate their ages and dynamical timescales. The cloud was mapped in the 870 micron continuum with APEX/LABOCA, and selected positions were observed in the lines of N2H+ and N2D+ using IRAM-30m. These were used together with our previous H2D+ observations. Moreover, archival FIR Spitzer/MIPS maps were combined with the LABOCA map to distinguish between pre- and protostellar cores, and to estimate the evolutionary stages of protostars. Twelve dense cores were detected at 870 micron in the Ori B9 cloud. The submm cores constitute ~4% of the total mass of the Ori B9 region. There is an equal number of pre- and protostellar cores. Two of the submm sources, which we call SMM 3 and SMM 4, are previously unknown Class 0 candidates. We found a moderate degree of deuteration in N2H+ (0.03-0.04). There is, furthermore, evidence for N2H+ depletion in the core SMM 4. We derive a relatively high degree of ioni...

  18. La théorie quantique en images

    CERN Document Server

    McEvoy, J P

    2014-01-01

    La théorie quantique nous confronte avec les paradoxes bizarres qui contredisent les fondements de la physique classique. Au niveau subatomique, une particule semble savoir ce que font les autres, mais selon « le principe d'incertitude » de Heisenberg, il y a une limite sur la précision des observations. Pourtant, la théorie quantique est étonnamment précise et largement appliquée en chimie et en physique. Cet ouvrage nous emmène dans un voyage où vous rencontrerez Planck, Einstein, Bohr, Heisenberg et Schrödinger, chacun d'entre eux ayant contribué aux concepts de cette théorie révolutionnaire. La dualité onde-particule, l'interprétation de Copenhague, le chat de Schrödinger, le paradoxe EPR etc... sont autant d'expériences et de concepts qui sont décrits dans cet ouvrage.

  19. Cellular response to 5-fluorouracil (5-FU in 5-FU-resistant colon cancer cell lines during treatment and recovery

    Directory of Open Access Journals (Sweden)

    Kravik Katherine L

    2006-05-01

    Full Text Available Abstract Background Treatment of cells with the anti-cancer drug 5-fluorouracil (5-FU causes DNA damage, which in turn affects cell proliferation and survival. Two stable wild-type TP53 5-FU-resistant cell lines, ContinB and ContinD, generated from the HCT116 colon cancer cell line, demonstrate moderate and strong resistance to 5-FU, respectively, markedly-reduced levels of 5-FU-induced apoptosis, and alterations in expression levels of a number of key cell cycle- and apoptosis-regulatory genes as a result of resistance development. The aim of the present study was to determine potential differential responses to 8 and 24-hour 5-FU treatment in these resistant cell lines. We assessed levels of 5-FU uptake into DNA, cell cycle effects and apoptosis induction throughout treatment and recovery periods for each cell line, and alterations in expression levels of DNA damage response-, cell cycle- and apoptosis-regulatory genes in response to short-term drug exposure. Results 5-FU treatment for 24 hours resulted in S phase arrests, p53 accumulation, up-regulation of p53-target genes on DNA damage response (ATF3, GADD34, GADD45A, PCNA, cell cycle-regulatory (CDKN1A, and apoptosis-regulatory pathways (FAS, and apoptosis induction in the parental and resistant cell lines. Levels of 5-FU incorporation into DNA were similar for the cell lines. The pattern of cell cycle progression during recovery demonstrated consistently that the 5-FU-resistant cell lines had the smallest S phase fractions and the largest G2(/M fractions. The strongly 5-FU-resistant ContinD cell line had the smallest S phase arrests, the lowest CDKN1A levels, and the lowest levels of 5-FU-induced apoptosis throughout the treatment and recovery periods, and the fastest recovery of exponential growth (10 days compared to the other two cell lines. The moderately 5-FU-resistant ContinB cell line had comparatively lower apoptotic levels than the parental cells during treatment and recovery

  20. Eléments de théorie des graphes

    CERN Document Server

    Bretto, Alain; Hennecart, François

    2012-01-01

    Ce livre est une introduction d velopp e la th orie des graphes. Autour de cette th orie se d veloppe aujourd'hui l'un des domaines les plus f conds et les plus dynamiques des mah matiques et de l'informatique. La th orie des graphes permet de r pr senter un ensemble complexe d'objets en exprimant les relations entre les l ments: r seaux de communication, circuits lectriques, etc. Le livre pr sente le langage et les notions l mentaires de cette th orie, les diff rents types de graphes (bipartis, arbres, arborescences, graphes eul riens et hamiltoniens, etc.); il tudie les relations entre les g

  1. Rossiter-mclaughlin effect in emission from UX Ori stars

    Science.gov (United States)

    Grinin, V. P.; Potravnov, I. S.

    2013-03-01

    The possibility of detecting changes in the radial velocities of UX Ori stars during eclipses by circumstellar dust clouds is examined. Calculations show that, despite the large sizes of the clouds, this effect may actually be observable and, perhaps, has already been observed during spectral studies of stars of this kind. Monitoring of events of this kind can provide important information about the motion of matter in close proximity to young stars, as well as about the structure of gas-dust clouds shielding a star.

  2. Orbicularis oris musculomucosal flap for anterior palatal fistula

    Directory of Open Access Journals (Sweden)

    Tiwari V

    2006-01-01

    Full Text Available Anterior palatal fistulae or residual anterior clefts are a frequent problem following palatoplasty. Various techniques have been used to repair such fistulae, each having its own advantages and disadvantages. We have successfully used orbicularis oris musculomucosal flap to close anterior fistula and residual clefts in 25 patients. This study shows the superiority of this flap over other techniques because of its reliable blood supply, easy elevation and transfer to fistula site and finally because it is a single-stage procedure.

  3. Understanding the photometric variability of {\\zeta} Ori Aa

    CERN Document Server

    Buysschaert, B; Ramiaramanantsoa, T; Richardson, N D; David-Uraz, A; Moffat, A F J

    2016-01-01

    We studied the variability of the magnetic O-type supergiant $\\zeta$ Ori Aa using multi-colour BRITE photometry. We confirmed the known rotation frequency $f_{\\rm rot} = 0.15 \\pm 0.02$ c/d, and detected some of its higher harmonics, of which $4f_{\\rm rot}$ is compatible with the known DAC recurrence timescale. Thanks to simultaneous high-resolution CHIRON spectroscopy, we could identify another frequency $f_{\\rm env} = 0.10 \\pm 0.02$ c/d, caused by the circumstellar environment. Variations in the circumstellar environment are believed to cause the observed difference between the BRITE lightcurves.

  4. MFL-P Chemotherapy for Pretreated Metastatic Breast Cancer Patients: A Regimen with Triple Biochemical Modulation by MTX-5FU, LV-5FU and 5FU-CDDP.

    Science.gov (United States)

    Kan; Honda

    1999-07-25

    BACKGROUND: Chemotherapeutic regimens, such as cyclophosphamide + doxorubicin + 5FU (CAF) or cyclophosphamide + methotrexate + 5FU (CMF), are sometimes used in combination with endocrine or radiotherapy as a standard first line of treatment for recurrent or metastatic breast cancer. However, many cases are, or become, refractory to these treatments. METHODS: Twenty-one women with recurrent or metastatic breast cancer who previously underwent treatment were administered our original regimen of combinationchemotherapy, MFL-P: Day 1, bolus methotrexate (MTX) 50 mg/body (median dose, 33 mg/m(2); range, 29-35 mg/m(2)) and 4 hours later 5-fluorouracil (5FU) 750 mg/body/h (median dose, 497 mg/m(2)/h; range, 441-528 mg/m(2) /h); Days 2-3, bolus leucovorin(LV) 15 mg/body every 8 h x 3; Days 2-5, 72 hours continuous 5FU 750 mg/body/24h; Day 6, cisplatin (CDDP) 50 mg/body/h (median dose, 33 mg/m(2)/h; range, 29-35 mg/m(2) /h) with sufficient hydration. The subjects ranged in age from 26 to 63 years (mean age, 51.3 years). RESULTS: One complete and 9 partial responses were achieved among the 20 patients (response rate, 50%). In 1 patient, diffuse liver metastasis was not measurable. Among various metastatic sites, a higher response rate was observed especially for soft tissue lesions (skin, chest wall and lymph nodes; 9 responders among 11 lesions). On the other hand, in visceral or skeletal metastases, the response rate was poor. The adverse effects were tolerable in all patients, except for common low-grade stomatitis or anorexia. CONCLUSION: MFL-P is useful as a second or third line of therapy for patients with refractory, recurrent or metastatic breast cancer with soft tissues lesions.

  5. Extreme Asymmetry in the Disk of V1247 Ori

    CERN Document Server

    Ohta, Yurina; Sitko, Michael L; Muto, Takayuki; Kraus, Stefan; Grady, Carol A; Wisniewski, John P; Swearingen, Jeremy R; Shibai, Hiroshi; Sumi, Takahiro; Hashimoto, Jun; Kudo, Tomoyuki; Kusakabe, Nobuhiko; Momose, Munetake; Okamoto, Yoshiko; Kotani, Takayuki; Takami, Michihiro; Currie, Thayne; Thalmann, Christian; Janson, Markus; Akiyama, Eiji; Follette, Katherine B; Mayama, Satoshi; Abe, Lyu; Brandner, Wolfgang; Brandt, Timothy D; Carson, Joseph C; Egner, Sebastian E; Feldt, Markus; Goto, Miwa; Guyon, Olivier; Hayano, Yutaka; Hayashi, Masahiko; Hayashi, Saeko S; Henning, Thomas; Hodapp, Klaus W; Ishii, Miki; Iye, Masanori; Kandori, Ryo; Knapp, Gillian R; Kuzuhara, Masayuki; Kwon, Jungmi; Matsuo, Taro; McElwain, Michael W; Miyama, Shoken; Morino, Jun-Ichi; Moro-Martin, Amaya; Nishimura, Tetsuo; Pyo, Tae-Soo; Serabyn, Eugene; Suenaga, Takuya; Suto, Hiroshi; Suzuki, Ryuji; Takahashi, Yasuhiro H; Takami, Hideki; Takato, Naruhisa; Terada, Hiroshi; Tomono, Daigo; Turner, Edwin L; Usuda, Tomonori; Watanabe, Makoto; Yamada, Toru; Tamura, Motohide

    2016-01-01

    We present the first near-infrared scattered-light detection of the transitional disk around V1247 Ori, which was obtained using high-resolution polarimetric differential imaging observations with Subaru/HiCIAO. Our imaging in the H band reveals the disk morphology at separations of ~0.14"-0.86" (54-330 au) from the central star. The polarized intensity (PI) image shows a remarkable arc-like structure toward the southeast of the star, whereas the fainter northwest region does not exhibit any notable features. The shape of the arm is consistent with an arc of 0.28" $\\pm$ 0.09" in radius (108 au from the star), although the possibility of a spiral arm with a small pitch angle cannot be excluded. V1247 Ori features an exceptionally large azimuthal contrast in scattered, polarized light; the radial peak of the southeastern arc is about three times brighter than the northwestern disk measured at the same distance from the star. Combined with the previous indication of an inhomogeneous density distribution in the g...

  6. Eric Cantona: Fußball-Ikone der modernen Medienwelt

    Directory of Open Access Journals (Sweden)

    Martin Wassermair

    2010-03-01

    Full Text Available In Unterhaltungsindustrie und Massenmedien nimmt der Sport eine im wahrsten Sinne des Wortes bewegende Rolle ein. Er ist zugleich Wettkampf-Arena und Wunschmaschine, Werbefläche und Starproduktion. Dass die Erscheinungsformen des Sports in der modernen Medienwelt einer rasanten Dynamik und Wechselbeziehung unterliegen, ist am Beispiel des Massenphänomens Fußballs vielleicht am deutlichsten abzulesen.

  7. 论扬雄赋%On YANG XIONG-FU

    Institute of Scientific and Technical Information of China (English)

    蓝旭

    2001-01-01

    As a renowned writer of Fu (赋), Yangxiong attached importance to satire, develop-ing new satirical techniques. He mingled light satire with the main body of Dafu (大赋)totouch on the work's themea. He utilized many literary quotations within his Dafu and em-ployed narration interspersed with commentary to give voice to many of his personal medita-tions on history and antiquity. The achievement of his Dafu is that he changed the traditionalstyle in which description and satire come together. He attained a transition from Dafu toYanzhi -Fu (言志赋), which gave expression to his aspirations in his later life. His Dafu alsoinspired the Jixing-fu (纪行赋) writers. Yangxiong'Yanzhi-fu embodies a mixture of Con-fucianism, Daoism, and Sso (aliterary style of the Pre-qin times). His works demonstratea pursuit for individual independence, freedom, and the preservation of moral value. Bridgingthe transition from Dafu to Yanzhi-fu, his works contain great significance to HanFu'history: he isthe linkbetween early and late Han Fu.%扬雄大赋重视讽谏,并开辟了新的讽谏手法,即正文中杂以微讽,以点醒题旨;大量用典,夹叙夹议,以及结合行踪咏史怀古的体格。其意义在于试图摆脱描写与讽谏游离的格套,从而自然过渡到他本人后期的言志赋,也启发了以后的纪行赋作家。扬雄的言志赋则体现出儒、道、骚融合的倾向,既追求个体的独立和自由,又并不废弃道德操守的价值。他的创作从大赋到言志赋的发展,在汉赋史上具有承上启下的意义。

  8. Translation Style of Fu Lei's—The Conquest of Happiness

    Institute of Scientific and Technical Information of China (English)

    李敏

    2016-01-01

    Mr. Fu Lei was a famous French literature translator. Most of the works are translated from Balzac, Roman Rolland, Voltaire, Merimee ect. This article through the analysis of The Conquest of Happiness to further study on Fu lei's translation style.

  9. Preliminary observations indicate variable patterns of plasma 5-fluorouracil (5-FU) levels during dose optimization of infusional 5-FU in colorectal cancer patients.

    Science.gov (United States)

    Kline, Christina Leah; Sheikh, Hassan S; Scicchitano, Angelique; Gingrich, Rebecca; Beachler, Cheryl; Finnberg, Niklas K; Liao, Jason; Sivik, Jeffrey; El-Deiry, Wafik S

    2011-10-01

    Efforts to improve efficacy and minimize toxicity have led to pharmacokinetic monitoring of plasma 5-Fluorouracil (5-FU) levels in colorectal cancer patients undergoing chemotherapy. We observed variation in basal 5-FU levels in 21 patients and significant variation during subsequent dose optimization. Tumor KRAS, BRAF mutations and TS mRNA levels were determined. Regimens included FOLFOX6 + Avastin (N = 8), FOLFOX6 (N = 11), FOLFIRI (N = 1) and FOLFOX4 (N = 1). Mutations identified in tumors included G12V KRAS (N = 2), G12A KRAS (N = 1), and V600E BRAF (N = 3). Six-of-eleven patients with normalized tumor TS mRNA levels 5-FU AUC of 20 mg.h/L or greater, and 80% of patients (4 of 5) with TS levels > 4.0 had a plasma 5-FU AUC of less than or equal to 20 mg.h/L. Approximately 2/3 of patients achieved therapeutic 5-FU AUC levels with 0-2 dose adjustments while a sub-group of ~1/3 of patients slowly achieved therapeutic levels (> 3-4 dose increases leading to supra-therapeutic 5-FU and subsequent reductions to lesser than original doses). Liver metastases and tumor TS levels did not fully account for variable 5-FU AUC optimization patterns. The 5-FU level during continuous infusion was half-therapeutic in one patient who received FOLFOX4. The observed heterogeneous patterns at baseline and during dose optimization of 5-FU levels suggest variations in 5-FU metabolism among treated patients. Physiological and/or genetic differences underlying heterogeneity in 5-FU levels during dose optimization require further study of patient demographics, single nucleotide polymorphisms in Dihydropyrimidine Dehydrogenase (DPD), TS, or other genes that impact 5-FU metabolism and gene expression changes in liver after 5-FU therapy.

  10. Multicenter randomized phase III trial comparing protracted venous infusion (PVI) fluorouracil (5-FU) with PVI 5-FU plus mitomycin in inoperable pancreatic cancer.

    Science.gov (United States)

    Maisey, Nick; Chau, Ian; Cunningham, David; Norman, Andrew; Seymour, Matt; Hickish, Tamas; Iveson, Tim; O'Brien, Mary; Tebbutt, Niall; Harrington, Angela; Hill, Mark

    2002-07-15

    To compare protracted venous infusion (PVI) fluorouracil (5-FU) with PVI 5-FU plus mitomycin (MMC) in patients with advanced pancreatic cancer in a multicenter, prospectively randomized study. Two hundred eight patients were randomized to PVI 5-FU (300 mg/m(2)/d for a maximum of 24 weeks) or PVI 5-FU plus MMC (7 mg/m(2) every 6 weeks for four courses). The major end points were tumor response, survival, toxicity, and quality of life (QOL). The two treatment groups were balanced for baseline demographic factors, and 62% had metastatic disease. The overall response rate was 8.4% (95% confidence interval [CI]) 3.2% to 13.7% for patients treated with PVI 5-FU alone compared with 17.6%; 95% CI 10.3% to 25.1% for PVI 5-FU plus MMC (P =.04). Median failure-free survival was 2.8 months for PVI 5-FU and 3.8 months for PVI 5-FU plus MMC (P =.14). Median survival was 5.1 months for PVI 5-FU and 6.5 months for PVI 5-FU plus MMC (P =.34). Toxicities in both arms were mild. There was an increased incidence of neutropenia in the 5-FU plus MMC arm (P PVI 5-FU plus MMC resulted in a superior response rate in comparison with PVI 5-FU alone in advanced pancreatic cancer, but this did not translate into a survival advantage. These results emphasize the importance of chemotherapy in this setting and the continuing value of the fluoropyrimidines in pancreatic cancer.

  11. Selective protection by uridine of growth inhibition by 5-fluorouracil (5FU) mediated by 5FU incorporation into RNA, but not the thymidylate synthase mediated growth inhibition by 5FU-leucovorin.

    Science.gov (United States)

    Codacci-Pisanelli, G; Noordhuis, P; van der Wilt, C L; Peters, G J

    2008-06-01

    Fluorouracil (5FU) acts by RNA-incorporation and inhibition of thymidylate synthase; the first action is counteracted by uridine, and the second is enhanced by leucovorin (LV). Growth inhibition of C26-10 colon cancer cells by 5FU was enhanced by LV and rescued by uridine, but 5FU-LV was only partially rescued by uridine. In WiDr cells, 5FU sensitivity was not enhanced by LV, while both 5FU and 5FU-LV were rescued by uridine. Intermediate trends were found in SW948 and HT29 cells. Uridine rescue in mice allowed 1.5-fold increase in 5FU dose, leading to 2-fold increase in the antitumor effect and thymidylate synthase inhibition in resistant Colon-26 tumors. In the sensitive Colon-26-10 tumor, uridine rescue decreased 5FU-RNA incorporation > 10-fold, without affecting the antitumor activity. The use of LV and uridine can differentiate between two mechanisms of action of 5FU.

  12. Rifampicin resistant initiation of chromosome replication from oriC in ihf mutants

    DEFF Research Database (Denmark)

    von Freiesleben, Ulrik; Rasmussen, Knud V.; Atlung, Tove

    2000-01-01

    IHF (integration host factor) mutants exhibit asynchronous initiation of chromosome replication from oriC as determined from flow cytometric analysis of cultures where RNA synthesis was inhibited with rifampicin. However, the run-out kinetics of chromosome replication in ihf mutants shows...... that they continue to produce oriCs for some time in the absence of RNA synthesis resulting in a twofold increase in the oriC per mass ratio. An ihf dnaA double mutant did not exhibit this continued increase of the oriC per mass ratio. This indicates that ihf mutants can initiate replication from ori......C in a rifampicin-resistant initiation mode but requires fully functional DnaA protein. The origin per mass ratio, determined by a quantitative Southern blotting technique, showed that the ihf mutants had an origin per mass ratio that was 60% of the wild type although it had a normal DnaA protein concentration...

  13. Postulat de la monnaie et théorie de la valeur chez Marx

    OpenAIRE

    Piluso, Nicolas

    2014-01-01

    L’article tente de réévaluer la portée de la critique de Carlo Benetti au sujet de la théorie de la monnaie marxienne. Si effectivement il n’est pas possible de déduire logiquement la théorie de la monnaie de la théorie de la marchandise chez Marx, nous proposons de postuler la monnaie à l’intérieur même de la théorie de la valeur. Ce type de postulat serait fondamentalement différent du postulat keynésien de la monnaie qui conduit à rejeter la théorie de la valeur et de la répartition. Cette...

  14. In vivo mutagenesis reveals that OriL is essential for mitochondrial DNA replication

    Science.gov (United States)

    Wanrooij, Sjoerd; Miralles Fusté, Javier; Stewart, James B; Wanrooij, Paulina H; Samuelsson, Tore; Larsson, Nils-Göran; Gustafsson, Claes M; Falkenberg, Maria

    2012-01-01

    The mechanisms of mitochondrial DNA replication have been hotly debated for a decade. The strand-displacement model states that lagging-strand DNA synthesis is initiated from the origin of light-strand DNA replication (OriL), whereas the strand-coupled model implies that OriL is dispensable. Mammalian mitochondria cannot be transfected and the requirements of OriL in vivo have therefore not been addressed. We here use in vivo saturation mutagenesis to demonstrate that OriL is essential for mtDNA maintenance in the mouse. Biochemical and bioinformatic analyses show that OriL is functionally conserved in vertebrates. Our findings strongly support the strand-displacement model for mtDNA replication. PMID:23090476

  15. Study on synthesis and distribution in vivo of 5-Fu-cholic acid conjugate

    Institute of Scientific and Technical Information of China (English)

    Jie Li; Li Hai; Wei Jia Liu; Xiao Chun Wu; Yong Wu

    2009-01-01

    A series of hepatic targeting drugs,5-Fu-cholic acid conjugate T1-T5,were synthesized.5-Fu and cholic acid was selected as starting material,after N-hydroxymethylation,condensation,hydrogenolysis to obtain carboxylated 5-Fu 5a--e.Carboxylated 5-Fu 5a--e were eondensated with intermediate 3-hydroxyethyl cholic acid benzyl ester 6 to get 7a-e,7a-e were deproteeted to get T1-T5.

  16. Ori-Finder 2, an integrated tool to predict replication origins in the archaeal genomes

    Directory of Open Access Journals (Sweden)

    Hao eLuo

    2014-09-01

    Full Text Available DNA replication is one of the most basic processes in all three domains of cellular life. With the advent of the post-genomic era, the increasing number of complete archaeal genomes has created an opportunity for exploration of the molecular mechanisms for initiating cellular DNA replication by in vivo experiments as well as in silico analysis. However, the location of replication origins (oriCs in many sequenced archaeal genomes remains unknown. We present a web-based tool Ori-Finder 2 to predict oriCs in the archaeal genomes automatically, based on the integrated method comprising the analysis of base composition asymmetry using the Z-curve method, the distribution of Origin Recognition Boxes (ORBs identified by FIMO tool, and the occurrence of genes frequently close to oriCs. The web server is also able to analyze the unannotated genome sequences by integrating with gene prediction pipelines and BLAST software for gene identification and function annotation. The result of the predicted oriCs is displayed as an HTML table, which offers an intuitive way to browse the result in graphical and tabular form. The software presented here is accurate for the genomes with single oriC, but it does not necessarily find all the origins of replication for the genomes with multiple oriCs. Ori-Finder 2 aims to become a useful platform for the identification and analysis of oriCs in the archaeal genomes, which would provide insight into the replication mechanisms in archaea. The web server is freely available at http://tubic.tju.edu.cn/Ori-Finder2/.

  17. o-star _1 ori c: confronting observations

    Directory of Open Access Journals (Sweden)

    Yaël Nazé

    2008-01-01

    Full Text Available En a~nos recientes, las estrellas de la categor a Of?p han revelado una multitud de fen omenos peculiares: per les de l neas variables, cambios fotom etricos y exceso de luminosidad en rayos X son solamente algunas de sus caracter sticas. Aqu repasamos sus propiedades f sicas, para facilitar comparaciones entre los miembros gal acticos de esta clase. Dado que uno de ellos se ha propuesto como semejante al rotador magn etico oblicuo 1 Ori C, aunque con un per odo m as largo, este ultimo objeto est a tambi en incluido en nuestro estudio, para ilustrar sus similitudes y diferencias con la categor a Of?p.

  18. Dario Battistella, Théories des relations internationales

    OpenAIRE

    Blanchard, Jean-François

    2016-01-01

    Les soubresauts de l’Histoire contemporaine tempèrent régulièrement l’ambition scientifique des internationalistes. Certains d’eux ont vécu le 11 septembre 2001 comme «  la surprise conceptuelle absolue  » (p. 561). De toute évidence, la construction d’une théorie des relations internationales (R.I.) dédiée à la compréhension et à l’explication de la structure anarchique (p. 26) du milieu international n’apparait pas évidente. Depuis que la discipline existe sous sa forme moderne (1918), l’oc...

  19. Noma (cancrum oris) in the South African context.

    Science.gov (United States)

    Feller, L; Altini, M; Chandran, R; Khammissa, R A G; Masipa, J N; Mohamed, A; Lemmer, J

    2014-01-01

    Noma (cancrum oris) is a destructive necrotising disease affecting orofacial tissues predominantly of malnourished young children. It is characterised by a rapid acute onset which usually starts in the mouth, spreads intra-orally destroying soft tissue and bone and progresses to perforate the facial skin, causing disfigurement. Polybacterial anaerobic infection is critical too, but is not alone sufficient for the initiation of noma. Cofactors, first and foremost malnutrition, but also systemic viral and bacterial infections are crucial to the development of noma. A patient with necrotising stomatitis or noma must be admitted to hospital for antibiotic treatment, fluid and electrolytes as well as nutritional supplementation and general supportive treatment. The epidemiology of noma in the South African population is unknown, and the clinicopathological features are poorly characterised. Although worldwide there is no evidence that HIV infection is a strong risk factor for noma, HIV infection may play a substantial role in the pathogenesis of noma in South Africa.

  20. A profile of prognostic and molecular factors in European and Māori breast cancer patients

    Directory of Open Access Journals (Sweden)

    Cheale Michelle

    2010-10-01

    Full Text Available Abstract Background New Zealand Māori have a poorer outcome from breast cancer than non-Māori, yet prognostic data are sparse. The objective of this study was to quantify levels of prognostic factors in a cohort of self-declared Māori and European breast cancer patients from Christchurch, New Zealand. Methods and Results Clinicopathological and survival data from 337 consecutive breast cancer patients (27 Māori, 310 European were evaluated. Fewer tumours were high grade in Māori women than European women (p = 0.027. No significant ethnic differences were detected for node status, tumour type, tumour size, human epidermal growth factor receptor, oestrogen and progesterone receptor (ER/PR status, or survival. In addition, tumour and serum samples from a sub-cohort of 14 Māori matched to 14 NZ European patients were analyzed by immunohistochemistry and enzyme linked immunosorbent assay for molecular prognostic factors. Significant correlations were detected between increased grade and increased levels of hypoxia inducible factor-1 (HIF-1α, glucose transporter-1 (GLUT-1, microvessel density (MVD and cytokeratins CK5/6 (p Conclusions In this Christchurch cohort of breast cancer patients, Māori women were no more likely than European women to have pathological or molecular factors predictive of poor prognosis. These data contrast with data from the North Island NZ, and suggest potential regional differences.

  1. [Modeling 5-FU clearance during a chronomodulated infusion].

    Science.gov (United States)

    Kwiatkowski, F; Chevalier, V; Chevrier, R; Richard, D; Cure, H; Chollet, P

    2003-06-01

    Drugs pharmacokinetic control is a usual practice in case of flat continuous infusions. It enables among others, to modulate delivered doses when drug concentrations in blood appear too high. With chronotherapy, this possibility becomes more difficult because of sinusoidal outflows of infusion. We propose here a method that enables this follow-up, established through the study of 21 metastatic colorectal cancer patients, treated with a chronomodulated infusion of high dose 5-fluoro-uracil (5-FU) and folinic acid. This pharmacokinetic follow-up permitted the modelisation of 5-FU clearance and the calculation of an index, which was, in our study, correlated to the treatment response and also to main encountered toxicities.

  2. Visuospatial attention and motor skills in kung fu athletes.

    Science.gov (United States)

    Muiños, Mónica; Ballesteros, Soledad

    2013-01-01

    The present study compared the performance of a group of sixteen kung fu athletes with that of a control group of fourteen nonathletes on a speeded visuospatial task and a hand-tapping motor task. In the visuospatial task the results showed that athletes were faster than the control participants when stimuli were presented at the periphery of the visual field at a middle and high presentation speed with short interstimulus intervals. Athletes were also significantly faster than nonathlete participants when performing motor actions such as hand-tapping with their dominant hand but groups did not differ with the nondominant hand. These results support the view that athletes perform some speeded visuospatial and motor tasks faster than nonathletes under certain conditions. The findings suggest that, after several years of practice, kung fu athletes develop certain skills that allow them to perform motor speed maneuvers under time pressure conditions.

  3. The Mid-infrared Evolution of the FU Orionis Disk

    Science.gov (United States)

    Green, Joel D.; Jones, Olivia C.; Keller, Luke D.; Poteet, Charles A.; Yang, Yao-Lun; Fischer, William J.; Evans, Neal J., II; Sargent, Benjamin A.; Rebull, Luisa M.

    2016-11-01

    We present new SOFIA-FORCAST observations obtained in 2016 February of the archetypal outbursting low-mass young stellar object FU Orionis, and we compare the continuum, solid-state, and gas properties with mid-infrared data obtained at the same wavelengths in 2004 with Spitzer-IRS. In this study, we conduct the first mid-infrared spectroscopic comparison of an FUor over a long time period. Over a 12-year period, UBVR monitoring indicates that FU Orionis has continued its steady decrease in overall brightness by ˜14%. We find that this decrease in luminosity occurs only at wavelengths ≲20 μm. In particular, the continuum shortward of the silicate emission complex at 10 μm exhibits a ˜12% (˜3σ) drop in flux density but no apparent change in slope; both the Spitzer and SOFIA spectra are consistent with a 7200 K blackbody. Additionally, the detection of water absorption is consistent with the Spitzer spectrum. The silicate emission feature at 10 μm continues to be consistent with unprocessed grains, unchanged over 12 years. We conclude that either the accretion rate in FU Orionis has decreased by ˜12-14% over this time baseline or the inner disk has cooled, but the accretion disk remains in a superheated state outside the innermost region.

  4. The Impact of FU Orionis Outbursts and the Solar Nebula

    Science.gov (United States)

    Bell, Robbins; Young, Richard E. (Technical Monitor)

    1998-01-01

    Protostellar systems are variable on many timescales. One of the most dramatic forms of variability known to occur in low mass stellar systems is the FU Orionis outburst (Herbig 1977). Throughout a typical outburst lasting several decades, system luminosities may be a hundred times what is typical of the quiesent state. FU Orionis outburst events are thought to have significant impact on the thermal structure of the protosolar nebula; their existence has been used to explain features in the meteoritic record from thermally induced homogenization to the formation of chondrules. Until recently, the magnitude of the likely effect from such outbursts has been largely speculative due to the lack of a detailed understanding of the outburst mechanism. Recent numerical models (Bell\\& Lin 1994) have demonstrated the viability of the observational hypothesis (Hartmann\\& Kenyon 1985) that the radiation observed during outburst is emitted by a luminous circumstellar disk transporting mass at a thousand times the quiesent rate. Light curves and color and line width evolution observed in FU Orionis systems are naturally explained by time dependent outbursting model disks (Bell et al. 1995). The radial temperature structure and shape of the disk during outburst derived from these models may be used to calculate the outburst's expected impact on primitive material at various radii throughout the disk. In this review, we will begin by discussing what is known about the FU Orionis outburst phenomenon from recent observations and theory including statistically deduced outburst timescales and observed peak temperatures. Unless covered by another author, we will discuss the evidence which suggests that outburst radiation is emitted by a circumstellar disk rather than by the star and will briefly review the thermal instability as a mechanism for outburst. We will then report on recent work which investigates the likely heating of solar nebula material due to FU Orionis outbursts

  5. UX Ori Variables in the Cluster IC 348

    Science.gov (United States)

    Barsunova, O. Yu.; Grinin, V. P.; Sergeev, S. G.; Semenov, A. O.; Shugarov, S. Yu.

    2015-06-01

    Results are presented from many years of photometric (VRCIC) observations of three variable T Tauri type stars in the cluster IC 348: V712 Per, V719 Per, and V909 Per. All three stars have photometric activity characteristic of UX Ori stars. The activity of V719 Per has increased significantly over the last 10 years: the amplitude of its Algol-like minima has increased by roughly a factor of 4 and has reached three stellar magnitudes in the I band. Periodograms of the light curves do not confirm the periods found previously by other authors on the basis of shorter series of observations. The slope of the color tracks on "color-magnitude" diagrams is used to determine the reddening law for these stars owing to selective absorption by circumstellar dust. Modelling of these parameters by the Mie theory shows that the maximum size amax of the dust particles in the protoplanetary disks of these stars is 1.5-2 times greater than in the interstellar medium. In V712 Per and V909 Per, the bulk of the mass of the dust particles is concentrated near amax, while in V719 Per the average mass of the dust particles is determined by the minimum size of the particles. It should be emphasized that these conclusions rely on an analysis of the optical variability of these stars.

  6. Intertextualité et théorie

    Directory of Open Access Journals (Sweden)

    Frank Wagner

    2006-09-01

    Full Text Available La relation d’interlocution de texte à texte(s que l’on nomme intertextualité est également toujours, à quelque degré, relation de commentaire – à valeur historique, idéolo­gique, esthétique et théorique. Ce lien indéfectible peut en grande partie s’expliquer par la proximité des concepts d’intertexte et de métatexte. Prenant appui sur ce postulat, je m’efforce de démontrer dans cet article que l’intertexte piran­dellien à l’œuvre dans Le Vol d’Icare, roman de Raymond Queneau, induit deux conceptions de « l’effet-personnage », et partant de la littérature, radicalement opposées. Plus généra­lement, je souhaiterais prouver qu’intertextualité et théorie sont consubstantielles, en raison de la dialectique de l’appar­tenance et de l’écart inhérente aux pratiques allusives et citationnelles.

  7. Te Reo Māori: indigenous language acquisition in the context of New Zealand English.

    Science.gov (United States)

    Reese, Elaine; Keegan, Peter; McNaughton, Stuart; Kingi, Te Kani; Carr, Polly Atatoa; Schmidt, Johanna; Mohal, Jatender; Grant, Cameron; Morton, Susan

    2017-07-06

    This study assessed the status of te reo Māori, the indigenous language of New Zealand, in the context of New Zealand English. From a broadly representative sample of 6327 two-year-olds (Growing Up in New Zealand), 6090 mothers (96%) reported their children understood English, and 763 mothers (12%) reported their children understood Māori. Parents completed the new MacArthur-Bates Communicative Development Inventory short forms for te reo Māori (NZM: CDI sf) and New Zealand English (NZE: CDI sf). Mothers with higher education levels had children with larger vocabularies in both te reo Māori and NZ English. For English speakers, vocabulary advantages also existed for girls, first-borns, monolinguals, those living in areas of lower deprivation, and those whose mothers had no concerns about their speech and language. Because more than 99% of Māori speakers were bilingual, te reo Māori acquisition appears to be occurring in the context of the acquisition of New Zealand English.

  8. Wavelet to predict bacterial ori and ter: a tendency towards a physical balance

    Directory of Open Access Journals (Sweden)

    Ware Antony

    2003-05-01

    Full Text Available Abstract Background Chromosomal DNA replication in bacteria starts at the origin (ori and the two replicores propagate in opposite directions up to the terminus (ter region. We hypothesize that the two replicores need to reach ter at the same time to maintain a physical balance; DNA insertion would disrupt such a balance, requiring chromosomal rearrangements to restore the balance. To test this hypothesis, we needed to demonstrate that ori and ter are in a physical balance in bacterial chromosomes. Using wavelet analysis, we documented GC skew, AT skew, purine excess and keto excess on the published bacterial genomic sequences to locate the turning (minimum and maximum points on the curves. Previously, the minimum point had been supposed to correlate with ori and the maximum to correlate with ter. Results We observed a strong tendency of the bacterial chromosomes towards a physical balance, with the minima and maxima corresponding to the known or putative ori and ter and being about half chromosome separated in most of the bacteria studied. A nonparametric method based on wavelet transformation was employed to perform significance tests for the predicted loci. Conclusions The wavelet approach can reliably predict the ori and ter regions and the bacterial chromosomes have a strong tendency towards a physical balance between ori and ter.

  9. Development of an oriC vector for use in Mycoplasma synoviae.

    Science.gov (United States)

    Shahid, Muhammad A; Marenda, Marc S; Markham, Philip F; Noormohammadi, Amir H

    2014-08-01

    Mycoplasma synoviae, an important poultry pathogen, belonging to the class Mollicutes, causes airsacculitis, synovitis, decreased egg production and produces significant economic losses. Efforts to determine M. synoviae virulence factors and their role in pathogenicity require suitable tools for genetic manipulation of this pathogen. This study describes, for the first time, the identification and cloning of the origin of replication (oriC) of M. synoviae to develop a replicable oriC vector for this mycoplasma. Shuttle vectors containing different putative oriC regions along with tetracycline resistance gene tetM were constructed to transform M. synoviae. An oriC vector, pMAS-LoriC, harbouring the complete dnaA gene along with upstream and downstream DnaA boxes, successfully transformed M. synoviae at an average transformation frequency of 1.07×10(-8) transformants per colony-forming unit (CFU), and remained freely replicating as well as integrated at the chromosomal oriC. Plasmid copy number for pMAS-LoriC was estimated to be 62±29 (average±SD) per cell. This study also provided evidence of the occurrence of homologous recombination and the functionality of the heterologous tetM determinant in M. synoviae. The transformation technique and the oriC vector developed in this study have the potential to be used in targeted gene disruption, gene complementation and expression studies in this organism. Copyright © 2014 Elsevier B.V. All rights reserved.

  10. Wavelet transform analysis of electromyography kung fu strikes data.

    Science.gov (United States)

    Neto, Osmar Pinto; Marzullo, Ana Carolina de Miranda

    2009-11-01

    In martial arts and contact sports strikes are performed at near maximum speeds. For that reason, electromyography (EMG) analysis of such movements is non-trivial. This paper has three main goals: firstly, to investigate the differences in the EMG activity of muscles during strikes performed with and without impacts; secondly, to assess the advantages of using Sum of Significant Power (SSP) values instead of root mean square (rms) values when analyzing EMG data; and lastly to introduce a new method of calculating median frequency values using wavelet transforms (WMDF). EMG data of the deltoid anterior (DA), triceps brachii (TB) and brachioradialis (BR) muscles were collected from eight Kung Fu practitioners during strikes performed with and without impacts. SSP results indicated significant higher muscle activity (p = 0.023) for the strikes with impact. WMDF results, on the other hand, indicated significant lower values (p = 0. 007) for the strikes with impact. SSP results presented higher sensitivity than rms to quantify important signal differences and, at the same time, presented lower inter-subject coefficient of variations. The result of increase in SSP values and decrease in WMDF may suggest better synchronization of motor units for the strikes with impact performed by the experienced Kung Fu practitioners. Key PointsThe results show higher muscle activity and lower electromyography median frequencies for strikes with impact compared to strikes without.SSP results presented higher sensitivity and lower inter-subject coefficient of variations than rms results.Kung Fu palm strikes with impact may present better motor units' synchronization than strikes without.

  11. Immediate effect of Fu's subcutaneous needling for low back pain

    Institute of Scientific and Technical Information of China (English)

    FU Zhong-hua; CHEN Xin-yuan; LU Li-juan; LIN Jian; XU Jian-guo

    2006-01-01

    @@ The traditional Chinese acupuncture has been reported to alleviate pain and is widely accepted as a complement therapy for pain relief in the world.1In 1996, a novel acupuncture strategy, Fu's subcutaneous needling (FSN), was developed from the traditional Chinese acupuncture, but quite different from it.2 In FSN, needles are penetrated and swayed in the subcutaneous layer, but not the muscular layer. The choosing of its insertion points doesn't obey the principles of traditional Chinese medicine. To date, FSN has been widely used by clinicians in China for its good job in pain management though the systemic and rigorous studies are still lack.

  12. 一款音色迷人de功放(Fu-5乙类)

    Institute of Scientific and Technical Information of China (English)

    师敬之; 汪卸言

    2009-01-01

    采用Fu-7作推挽激励。Fu-5推挽输出,老牌的Fu-5(原称805)是功放三极管,常规的屏压都设为1250V-1550V之间,栅负压取0~16V。广泛用于无线电短波通信发射机的功放。

  13. FuGEFlow: data model and markup language for flow cytometry.

    Science.gov (United States)

    Qian, Yu; Tchuvatkina, Olga; Spidlen, Josef; Wilkinson, Peter; Gasparetto, Maura; Jones, Andrew R; Manion, Frank J; Scheuermann, Richard H; Sekaly, Rafick-Pierre; Brinkman, Ryan R

    2009-06-16

    Flow cytometry technology is widely used in both health care and research. The rapid expansion of flow cytometry applications has outpaced the development of data storage and analysis tools. Collaborative efforts being taken to eliminate this gap include building common vocabularies and ontologies, designing generic data models, and defining data exchange formats. The Minimum Information about a Flow Cytometry Experiment (MIFlowCyt) standard was recently adopted by the International Society for Advancement of Cytometry. This standard guides researchers on the information that should be included in peer reviewed publications, but it is insufficient for data exchange and integration between computational systems. The Functional Genomics Experiment (FuGE) formalizes common aspects of comprehensive and high throughput experiments across different biological technologies. We have extended FuGE object model to accommodate flow cytometry data and metadata. We used the MagicDraw modelling tool to design a UML model (Flow-OM) according to the FuGE extension guidelines and the AndroMDA toolkit to transform the model to a markup language (Flow-ML). We mapped each MIFlowCyt term to either an existing FuGE class or to a new FuGEFlow class. The development environment was validated by comparing the official FuGE XSD to the schema we generated from the FuGE object model using our configuration. After the Flow-OM model was completed, the final version of the Flow-ML was generated and validated against an example MIFlowCyt compliant experiment description. The extension of FuGE for flow cytometry has resulted in a generic FuGE-compliant data model (FuGEFlow), which accommodates and links together all information required by MIFlowCyt. The FuGEFlow model can be used to build software and databases using FuGE software toolkits to facilitate automated exchange and manipulation of potentially large flow cytometry experimental data sets. Additional project documentation, including

  14. Andrographolide reversed 5-FU resistance in human colorectal cancer by elevating BAX expression.

    Science.gov (United States)

    Wang, Weicheng; Guo, Wenjie; Li, Lele; Fu, Zan; Liu, Wen; Gao, Jian; Shu, Yongqian; Xu, Qiang; Sun, Yang; Gu, Yanhong

    2016-12-01

    5-FU is the first line therapy for colorectal cancer, however, treatment effect is often hampered by the development of drug resistance or toxicity at high doses. Andrographolide is a natural diterpenoid from Andrographis paniculata which has anti-bacterial, anti-antiviral and anti-inflammation activities. In the current study, we test the hypothesis that Andrographolide reverses 5-FU resistance in colorectal cancer and examine the underlying mechanism. In vitro and vivo studies indicated that Andrographolide treatment significantly re-sensitizes HCT116/5-FUR cells (HCT116 cells which are 5-FU resistant) to cytotoxicity of 5-FU. Mechanism analysis showed that Andrographolide/5-FU co-treatment elevated apoptosis level of HCT116/5-FUR cells with highly increased level of BAX. By using biotin-Andrographolide pull down and cellular thermal shift assay, we found out that Andrographolide can directly target to BAX. Andrographolide-BAX interaction prevented BAX degradation, enhancing mitochondria-mediated apoptosis thus reversed 5-FU resistance while BAX silence diminished this effect. Further, by analyzing patient samples who received 5-FU involved chemotherapy, we found that expression level of BAX is correlated with PFS. Our results here provide a novel combination treatment strategy, especially for patients with 5-FU-resistant tumors expressing low level of BAX. Meanwhile, we also proposed that BAX expression may be a predicted and prognosis marker of 5-FU involved chemotherapy. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. FuGEFlow: data model and markup language for flow cytometry

    Directory of Open Access Journals (Sweden)

    Manion Frank J

    2009-06-01

    Full Text Available Abstract Background Flow cytometry technology is widely used in both health care and research. The rapid expansion of flow cytometry applications has outpaced the development of data storage and analysis tools. Collaborative efforts being taken to eliminate this gap include building common vocabularies and ontologies, designing generic data models, and defining data exchange formats. The Minimum Information about a Flow Cytometry Experiment (MIFlowCyt standard was recently adopted by the International Society for Advancement of Cytometry. This standard guides researchers on the information that should be included in peer reviewed publications, but it is insufficient for data exchange and integration between computational systems. The Functional Genomics Experiment (FuGE formalizes common aspects of comprehensive and high throughput experiments across different biological technologies. We have extended FuGE object model to accommodate flow cytometry data and metadata. Methods We used the MagicDraw modelling tool to design a UML model (Flow-OM according to the FuGE extension guidelines and the AndroMDA toolkit to transform the model to a markup language (Flow-ML. We mapped each MIFlowCyt term to either an existing FuGE class or to a new FuGEFlow class. The development environment was validated by comparing the official FuGE XSD to the schema we generated from the FuGE object model using our configuration. After the Flow-OM model was completed, the final version of the Flow-ML was generated and validated against an example MIFlowCyt compliant experiment description. Results The extension of FuGE for flow cytometry has resulted in a generic FuGE-compliant data model (FuGEFlow, which accommodates and links together all information required by MIFlowCyt. The FuGEFlow model can be used to build software and databases using FuGE software toolkits to facilitate automated exchange and manipulation of potentially large flow cytometry experimental data sets

  16. WAVELET TRANSFORM ANALYSIS OF ELECTROMYOGRAPHY KUNG FU STRIKES DATA

    Directory of Open Access Journals (Sweden)

    Ana Carolina de Miranda Marzullo

    2009-11-01

    Full Text Available In martial arts and contact sports strikes are performed at near maximum speeds. For that reason, electromyography (EMG analysis of such movements is non-trivial. This paper has three main goals: firstly, to investigate the differences in the EMG activity of muscles during strikes performed with and without impacts; secondly, to assess the advantages of using Sum of Significant Power (SSP values instead of root mean square (rms values when analyzing EMG data; and lastly to introduce a new method of calculating median frequency values using wavelet transforms (WMDF. EMG data of the deltoid anterior (DA, triceps brachii (TB and brachioradialis (BR muscles were collected from eight Kung Fu practitioners during strikes performed with and without impacts. SSP results indicated significant higher muscle activity (p = 0.023 for the strikes with impact. WMDF results, on the other hand, indicated significant lower values (p = 0. 007 for the strikes with impact. SSP results presented higher sensitivity than rms to quantify important signal differences and, at the same time, presented lower inter-subject coefficient of variations. The result of increase in SSP values and decrease in WMDF may suggest better synchronization of motor units for the strikes with impact performed by the experienced Kung Fu practitioners

  17. Force, reaction time, and precision of Kung Fu strikes.

    Science.gov (United States)

    Neto, Osmar Pinto; Bolander, Richard; Pacheco, Marcos Tadeu Tavares; Bir, Cynthia

    2009-08-01

    The goal was to compare values of force, precision, and reaction time of several martial arts punches and palm strikes performed by advanced and intermediate Kung Fu practitioners, both men and women. 13 Kung Fu practitioners, 10 men and three women, participated. Only the men, three advanced and seven intermediate, were considered for comparisons between levels. Reaction time values were obtained using two high speed cameras that recorded each strike at 2500 Hz. Force of impact was measured by a load cell. For comparisons of groups, force data were normalized by participant's body mass and height. Precision of the strikes was determined by a high speed pressure sensor. The results show that palm strikes were stronger than punches. Women in the study presented, on average, lower values of reaction time and force but higher values of precision than men. Advanced participants presented higher forces than intermediate participants. Significant negative correlations between the values of force and precision and the values of force and reaction time were also found.

  18. The Mid-Infrared Evolution of the FU Orionis Disk

    CERN Document Server

    Green, Joel D; Keller, Luke D; Poteet, Charles A; Yang, Yao-Lun; Fischer, William J; Evans, Neal J; Sargent, Benjamin A; Rebull, Luisa M

    2016-01-01

    We present new SOFIA-FORCAST observations obtained in Feburary 2016 of the archetypal outbursting low mass young stellar object FU Orionis, and compare the continuum, solid state, and gas properties with mid-IR data obtained at the same wavelengths in 2004 with Spitzer-IRS. In this study, we conduct the first mid-IR spectroscopic comparison of an FUor over a long time period. Over a 12 year period, UBVR monitoring indicates that FU Orionis has continued its steady decrease in overall brightness by ~ 14%. We find that this decrease in luminosity occurs only at wavelengths < 20 microns. In particular, the continuum short ward of the silicate emission complex at 10 microns exhibits a ~ 12% (~ 3 sigma) drop in flux density, but no apparent change in slope; both the Spitzer and SOFIA spectra are consistent with a 7200 K blackbody. Additionally, the detection of water absorption is consistent with the Spitzer spectrum. The silicate emission feature at 10 microns continues to be consistent with unprocessed grains...

  19. ORBITAL AND PHYSICAL PROPERTIES OF THE σ Ori Aa, Ab, B TRIPLE SYSTEM

    Energy Technology Data Exchange (ETDEWEB)

    Simón-Díaz, S. [Instituto de Astrofísica de Canarias, E-38200 La Laguna, Tenerife (Spain); Caballero, J. A.; Apellániz, J. Maíz [Centro de Astrobiología (CSIC-INTA), ESAC Campus, P.O. Box 78, E-28691 Villanueva de la Cañada, Madrid (Spain); Lorenzo, J.; Negueruela, I.; Dorda, R.; Marco, A. [Departamento de Física, Ingeniería de Sistemas y Teoría de la Señal, Escuela Politécnica Superior, University of Alicante, Apdo. 99, E-03080 Alicante (Spain); Schneider, F. R. N. [Argelander-Institut für Astronomie der Universität Bonn, Auf dem Hügel 71, D-53121 Bonn (Germany); Barbá, R. H. [Departamento de Física, Universidad de La Serena, Benavente 980, La Serena (Chile); Montes, D. [Departamento Astrofísica, Facultad de Ciencias Físicas, Universidad Complutense de Madrid, E-28040 Madrid (Spain); Pellerin, A. [Department of Physics and Astronomy, State University of New York at Geneseo, 1 College Circle, Geneseo, NY 14454 (United States); Sanchez-Bermudez, J.; Sota, A. [Instituto de Astrofísica de Andalucía (CSIC), Glorieta de la Astronomía s/n, E-18008 Granada (Spain); Sódor, Á., E-mail: ssimon@iac.es [Konkoly Observatory, Research Centre for Astronomy and Earth Sciences, Hungarian Academy of Sciences, H-01121 Budapest (Hungary)

    2015-02-01

    We provide a complete characterization of the astrophysical properties of the σ Ori Aa, Ab, B hierarchical triple system and an improved set of orbital parameters for the highly eccentric σ Ori Aa, Ab spectroscopic binary. We compiled a spectroscopic data set comprising 90 high-resolution spectra covering a total time span of 1963 days. We applied the Lehman-Filhés method for a detailed orbital analysis of the radial velocity curves and performed a combined quantitative spectroscopic analysis of the σ Ori Aa, Ab, B system by means of the stellar atmosphere code FASTWIND. We used our own plus other available information on photometry and distance to the system for measuring the radii, luminosities, and spectroscopic masses of the three components. We also inferred evolutionary masses and stellar ages using the Bayesian code BONNSAI. The orbital analysis of the new radial velocity curves led to a very accurate orbital solution of the σ Ori Aa, Ab pair. We provided indirect arguments indicating that σ Ori B is a fast-rotating early B dwarf. The FASTWIND+BONNSAI analysis showed that the Aa, Ab pair contains the hottest and most massive components of the triple system while σ Ori B is a bit cooler and less massive. The derived stellar ages of the inner pair are intriguingly younger than the one widely accepted for the σ Orionis cluster, at 3 ± 1 Ma. The outcome of this study will be of key importance for a precise determination of the distance to the σ Orionis cluster, the interpretation of the strong X-ray emission detected for σ Ori Aa, Ab, B, and the investigation of the formation and evolution of multiple massive stellar systems and substellar objects.

  20. Prevalence and predictors of disability for Māori 24 months after injury.

    Science.gov (United States)

    Wyeth, Emma H; Samaranayaka, Ari; Davie, Gabrielle; Derrett, Sarah

    2017-06-01

    To investigate post-injury disability prevalence and identify pre-injury and injury-related predictors 24 months post-injury among Māori Prospective Outcomes of Injury Study participants. Participants were recruited from New Zealand's no-fault injury insurer. Pre-injury and injury-related characteristic information was obtained from participants at three and 24 months post-injury. The World Health Organization Disability Assessment Schedule was used to measure disability. Multivariable models were developed to estimate relative risks of post-injury disability. Of 2,856 participants, 566 were Māori. Analyses were restricted to 374 Māori with pre-injury and 24-month post-injury disability data available. Pre-injury, 9% reported disability compared to 19% 24 months post-injury. Strong predictors of increased risk of disability 24 months post-injury were having ≥2 chronic conditions pre-injury and having trouble accessing healthcare services after injury. Hospitalisation for injury and having inadequate pre-injury household income were other predictors. Māori experience considerable disability 24 months post-injury. Pre-injury socio-demographic, health and psychosocial, and injury-related characteristics independently predict post-injury disability and provide focus for future research and interventions to improve Māori post-injury outcomes. Implications for public health: Despite having had access to services, injured Māori experienced considerable long-term disability. Pre-injury and injury-related factors predict long-term disability and should be the focus to reduce the post-injury disability burden for Māori. © 2017 The Authors.

  1. AKARI/FIS Mapping of the ISM-Wind Bow Shock around Alpha Ori

    CERN Document Server

    Ueta, Toshiya; Yamamura, Issei; Nakada, Yoshikazu; Matsuura, Mikako; Ita, Yoshifusa; Tanabe, Toshihiko; Fukushi, Hinako; Matsunaga, Noriyuki; Mito, Hiroyuki

    2008-01-01

    We present 10' x 50' scan maps around an M supergiant Alpha Ori at 65, 90, 140 and 160 microns obtained with the AKARI Infrared Astronomy Satellite. Higher spatial resolution data with the exact analytic solution permit us to fit the de-projected shape of the stellar wind bow shock around Alpha Ori to have the stand-off distance of 4.8', position angle of 55 degrees and inclination angle of 56 degrees. The shape of the bow shock suggests that the peculiar velocity of Alpha Ori with respect to the local medium is v_* = 40 (n_H)^(-1/2), where n_H is the hydrogen nucleus density at Alpha Ori. We find that the local medium is of n_H = 1.5 to 1.9 cm^(-3) and the velocity of the local flow is at 11 km s^(-1) by using the most recent astrometric solutions for Alpha Ori under the assumption that the local medium is moving away from the Orion OB 1 association. AKARI images may also reveal a vortex ring due to instabilities on the surface of the bow shock as demonstrated by numerical models. This research exemplifies t...

  2. A long-lasting quiescence phase of the eruptive variable V1118 Ori

    CERN Document Server

    Lorenzetti, D; Giannini, T; Harutyunyan, A; Arkharov, A A; Larionov, V M; Cusano, F; Di Paola, A; Causi, G Li; Nisini, B; Speziali, R; Vitali, F

    2015-01-01

    V1118 Ori is an eruptive variable belonging to the EXor class of Pre-Main Sequence stars whose episodic outbursts are attributed to disk accretion events. Since 2006, V1118 Ori is in the longest quiescence stage ever observed between two subsequent outbursts of its recent history. We present near-infrared photometry of V1118 Ori carried out during the last eight years, along with a complete spectroscopic coverage from 0.35 to 2.5 um. A longterm sampling of V1118 Ori in quiescence has never been done, hence we can benefit from the current circumstance to determine the lowest values (i.e. the zeroes) of the parameters to be used as a reference for evaluating the physical changes typical of more active phases. A quiescence mass accretion rate between 1--3 $\\times$ 10$^{-9}$ M$_{\\sun}$ yr$^{-1}$ can be derived and the difference with previous determinations is discussed. From line emission and IR colors analysis a visual extinction of 1-2 mag is consistently derived, confirming that V1118 Ori (at least in quiesce...

  3. A STAR-FORMING RING AROUND κ Ori 250 pc FROM THE SUN

    Energy Technology Data Exchange (ETDEWEB)

    Pillitteri, I.; Wolk, S. J. [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States); Megeath, S. T., E-mail: ipillitt@cfa.harvard.edu [Ritter Astrophysical Research Center, Department of Physics and Astronomy, University of Toledo, Toledo, OH (United States)

    2016-04-01

    X-rays are a powerful probe of activity in early stages of star formation. They allow us to identify young stars even after they have lost the IR signatures of circumstellar disks and provide constraints on their distance. Here, we report on XMM-Newton observations that detect 121 young stellar objects (YSOs) in two fields between L1641 S and κ Ori. These observations extend the Survey of Orion A with XMM and Spitzer (SOXS). The YSOs are contained in a ring of gas and dust apparent at millimeter wavelengths, and in far-IR and near-IR surveys. The X-ray luminosity function of the YSOs detected in the two fields indicates a distance of 250–280 pc, much closer than the Orion A cloud and similar to distance estimates of κ Ori. We propose that the ring is a 5–8 pc diameter shell that has been swept up by κ Ori. This ring contains several groups of stars detected by Spitzer and WISE including one surrounding the Herbig Ae/Be stars V1818 Ori. In this interpretation, the κ Ori ring is one of several shells swept up by massive stars within the Orion Eridanus Superbubble and is unrelated to the southern portion of Orion A/L1641 S.

  4. Chromosomal imbalance maps of human 5FU-resistant colorectal cancer cell lines: implications in the analysis of 5FU-acquired resistance mechanisms.

    Science.gov (United States)

    Plasencia, C; Rooney, P H; Taron, M; Martinez-Balibrea, E; McLeod, H L; Abad, A

    2003-05-01

    Thymidylate synthase (TS), a critical enzyme in the de novo synthesis of thymidylate, is an important target for fluoropyrimidines and folate-based TS inhibitors. Overexpression of TS has been correlated to 5-fluorouracil (5FU)-resistance. Because 5FU still remains a basic component of the treatment of colorectal cancer, circumvention of resistance is of vital importance. A panel of sensitive (HT29 and LoVo) and 5FU-resistant colorectal cancer cell lines (HT29-5FUR and LoVo-5FUR) were subjected to comparative genomic hybridization (CGH) analysis to identify possible amplified/deleted regions associated with 5FU-resistance in colon tumours. We have identified chromosomal gains at 5p, 6, 7p, 7q and 8q and one loss at 3q in 5FU-resistant cells as compared to corresponding sensitive cell lines. Neither chromosomal gains at 18p nor gene amplification of TS were observed in our resistant cell lines although an overexpression of TS gene exists (at mRNA level) in these cell lines as compared with corresponding parental cells. Most of the chromosomal gains identified in this study occur frequently in sporadic colorectal tumours and has been associated to a poor prognosis and a greater progression of the tumour and could be related to a worse chemotherapy response. The chromosomal imbalance profile detected in 5FU-resistant cell lines should provide a basis for interpreting mechanisms of 5FU-resistance in colorectal cancer and also possibly in other tumours treated with this agent. This study also identified new genes potentially implicated in 5FU-resistance and suggests new targets that could be useful for the chemotherapy treatment of colorectal cancer.

  5. Adenovirus KH901 promotes 5-FU antitumor efficacy and S phase in LoVo cells.

    Science.gov (United States)

    Peng, Wei; Li, Jin; Yin, X G; Xu, J F; Cheng, L Z

    2012-06-01

    A combination of oncolytic and chemotherapeutic agents has been used to kill cancer cells. However, the effect of oncolytic adenoviruses on the cell cycle remains to be determined. Cytotoxicity assays were performed to determine cell death in cells treated with 5-fluorouracil (5-FU) alone or in combination with the oncolytic adenovirus KH901. Dynamic changes in the cell cycle, cell proliferation, and apoptosis-related proteins including p-AKT, Bcl-2, Bax, and caspase 3 were investigated after treatment with 5-FU with or without KH901. A higher proportion of S-phase cells were observed after treatment with KH901 and 5-FU than with 5-FU alone. p-AKT, Bcl-2, and Bax expression was increased upon treatment with KH901, whereas the expression of caspase-3 was not induced upon treatment with KH901 with or without 5-FU. KH901 exhibited significant potential as an oncolytic adenovirus and increased cell death in combination with 5-FU in LoVo cells, as compared to 5-FU alone. In conclusion, KH901 stimulates LoVo cells to enter the S-phase by activation of p-AKT, which could partly explain its synergistic effect with 5-FU on LoVo cell cytotoxicity.

  6. 5FU and oxaliplatin-containing chemotherapy in two dihydropyrimidine dehydrogenase-deficient patients

    NARCIS (Netherlands)

    Reerink, O; Mulder, NH; Szabo, BG; Hospers, GAP

    2004-01-01

    Patients with a germline mutation leading to a deficiency of the dihydropyrimidine dehydrogenase (DPD) enzyme are at risk from developing severe toxicity on the administration of 5FU-containing chemotherapy. We report on the implications of this inborn genetic error in two patients who received 5FU

  7. Web-based alcohol screening and brief intervention for Māori and non-Māori: the New Zealand e-SBINZ trials

    Directory of Open Access Journals (Sweden)

    De Graaf Brandon

    2010-12-01

    Full Text Available Abstract Background Hazardous alcohol consumption is a leading modifiable cause of mortality and morbidity among young people. Screening and brief intervention (SBI is a key strategy to reduce alcohol-related harm in the community, and web-based approaches (e-SBI have advantages over practitioner-delivered approaches, being cheaper, more acceptable, administrable remotely and infinitely scalable. An efficacy trial in a university population showed a 10-minute intervention could reduce drinking by 11% for 6 months or more among 17-24 year-old undergraduate hazardous drinkers. The e-SBINZ study is designed to examine the effectiveness of e-SBI across a range of universities and among Māori and non-Māori students in New Zealand. Methods/Design The e-SBINZ study comprises two parallel, double blind, multi-site, individually randomised controlled trials. This paper outlines the background and design of the trial, which is recruiting 17-24 year-old students from seven of New Zealand's eight universities. Māori and non-Māori students are being sampled separately and are invited by e-mail to complete a web questionnaire including the AUDIT-C. Those who score >4 will be randomly allocated to no further contact until follow-up (control or to assessment and personalised feedback (intervention via computer. Follow-up assessment will occur 5 months later in second semester. Recruitment, consent, randomisation, intervention and follow-up are all online. Primary outcomes are (i total alcohol consumption, (ii frequency of drinking, (iii amount consumed per typical drinking occasion, (iv the proportions exceeding medical guidelines for acute and chronic harm, and (v scores on an academic problems scale. Discussion The trial will provide information on the effectiveness of e-SBI in reducing hazardous alcohol consumption across diverse university student populations with separate effect estimates for Māori and non-Māori students. Trial registration

  8. Photometric activity of UX Ori stars and related objects in the near infrared and visual. BF Ori, CQ Tau, WW Vul, and SV Cep

    Science.gov (United States)

    Shenavrin, V. I.; Grinin, V. P.; Rostopchina-Shakhovskaja, A. N.; Demidova, T. V.; Shakhovskoi, D. N.

    2012-05-01

    We have analyzed the activity of four UX Ori stars in the near-IR ( JHKL) and visual ( V) using the results of long-term photometric observations. For comparison, we also obtained IR ( JHKLM) photometric observations of two visually quiet young stars of close spectral types (AB Aur and HD 190073). For the photometrically most active UX Ori stars BF Ori, CQ Tau, and WW Vul, the Algol-like declines of brightness in the visual, which are due to sporadic enhancements of the circumstellar extinction, are also observed (with decreasing amplitude) in the IR bands. A strict correlation between the V and J brightness variations is observed for all the stars except for SV Cep. For some of the UX Ori stars, a strong correlation between the visual and IR activity is observed up to L, where the main contribution to the emission is made by circumstellar dust. In the case of SV Cep, the visual variability is not correlated with the variability of the IR fluxes. On one occasion, a clear anti-correlation was even observed: a shallow, but prolonged decrease of the visual brightness was accompanied by an increase in the IR fluxes. This indicates that circumstellar clouds themselves can become powerful sources of IR emission. Our results provide evidence that the photometric activity of UX Ori stars is a consequence of instability of the deepest layers of their gas-dust accretion disks. In some cases (SV Cep), fluctuations of the density in this region are global, in the sense that they occur along a significant part of the circle marking the inner boundary of the dust disk. It is interesting that AB Aur, which is the quietest in the visual, appeared to be the most active in the IR. In contrast to UX Ori stars, the amplitude of its brightness variations increases from the J to the M band. It follows from analysis of the IR colors of this star that their variability cannot be described by models in which the variable IR emission has a temperature close to the sublimation temperature of

  9. Mitomycin-C and 5- FU in ophthalmology: review article

    Directory of Open Access Journals (Sweden)

    M Jabbarvand Behrouz

    2009-03-01

    Full Text Available "nThe response of living tissues to the surgical trauma is associated with varying degrees of tissue repair and involves two distinct processes including replacement and regeneration. Replacement results in scar tissue formation instead of restoration of the normal architecture. However, regeneration leads to restoration of the original architecture leaving no sign of injury. Anti-proliferative agents are used to inhibit tissue responses to surgical trauma. Among them mitomycin- C and 5- FU had gained increasing applications in ophthalmic surgeries, including filtering glaucoma surgeries, laser vision correction with excimer laser by ablative surface refractive surgery, reconstructive surgeries for ocular surface disorders and removal of neoplastic tissues and secondary operations on nasolacrimal ducts. In this review article, the various aspects of applications of these agents including their mechanism of action, function, mode of application and complications in different ophthalmology fields are discussed.

  10. An upper limit to the mass of a close companion candidate to {\\sigma} Ori E

    CERN Document Server

    Caballero, José A; Lillo-Box, Jorge

    2016-01-01

    The famous, very young, helium rich, magnetically-active, radio and X-ray emitter, short-period rotationally variable, spectroscopically peculiar star {\\sigma} Ori E may have a close late-type stellar companion, which could explain flaring activity observed in some {\\sigma} Ori E X-ray light curves. In 2009, Bouy et al. announced the detection of a faint companion candidate in the Ks band at 0.330 arcsec (130 AU) to the B2 Vp primary. Here, we carry out z'-band lucky imaging with AstraLux at the 2.2 m Calar Alto telescope in an attempt to constrain the properties of the companion candidate to {\\sigma} Ori E. We impose a maximum mass of 2.0+0.2-0.1 Msol and an earliest spectral type of K2+/-1, which leaves the door open to a new, inexpensive, near-infrared, adaptive-optics study.

  11. Factors affecting the educational achievement of mature Māori information technology students: A case study

    Directory of Open Access Journals (Sweden)

    Blain Harre Rakena

    Full Text Available This paper reports on the results of an investigation into the experiences of academically successful adult Māori students undertaking the Bachelor of Information Technology (BIT programme at the Waikato Institute of Technology (Wintec. This research looked at the participants\\' motivation for attending Wintec, the barriers (such as financial, social and family hardships they encountered as they made the transition back to full time study, and their experiences at Wintec. The paper considers the reasons why the participants have achieved well, identifies the support systems they called on, and explores the challenges that they experienced while studying in a tertiary learning environment. Its significance lies in the focus on factors that affect Māori academic success, specifically in information technology, so that teaching approaches and support systems, particularly in the institute of technology and polytechnic (ITP sector, can enhance the success of Māori in the field of IT.

  12. Effect of Expiratory Resistive Loading in Expiratory Muscle Strength Training on Orbicularis Oris Muscle Activity

    OpenAIRE

    2014-01-01

    [Purpose] The purpose of this study was to elucidate the effect of expiratory resistive loading on orbicularis oris muscle activity. [Subjects] Subjects were 23 healthy individuals (11 males, mean age 25.5±4.3 years; 12 females, mean age 25.0±3.0 years). [Methods] Surface electromyography was performed to measure the activity of the orbicularis oris muscle during maximum lip closure and resistive loading at different expiratory pressures. Measurement was performed at 10%, 30%, 50%, and 100% o...

  13. De la place de la théorie de la valeur et de la monnaie dans la théorie de la régulation : critique et synthèse

    OpenAIRE

    Montalban, Matthieu

    2012-01-01

    Marxistes et régulationnistes s’opposent sur l’utilité de la théorie de la valeur, notamment la théorie de la valeur-travail. Nous montrons comment les régulationnistes, après avoir été pour certains des défenseurs de la théorie de la valeur-travail, l’ont abandonnée pour y substituer une théorie de la monnaie. Nous montrons que les problèmes centraux pour le marxisme sont celui de la socialisation des travaux privés par le marché et le fait que la théorie de la valeur-travail n’est plus util...

  14. Looking Māori predicts decreased rates of home ownership: institutional racism in housing based on perceived appearance.

    Science.gov (United States)

    Houkamau, Carla A; Sibley, Chris G

    2015-01-01

    This study examined differences in rates of home ownership among Māori (the indigenous peoples of New Zealand). We identified systematic factors that predicted why some Māori were more likely to own their own home (partially or fully) relative to other Māori. Data were drawn from a large national postal sample of 561 self-identified Māori collected as part of the New Zealand Attitudes and Values Study. As predicted, our analyses indicated that self-reported appearance as Māori, or the extent to which people thought they personally displayed features which visibly identified them as Māori to others, significantly predicted decreased rates of home ownership. This association held when adjusting for numerous demographic covariates, such as education, level of deprivation of the immediate area, household income, age, relationship status, region of residence, and so forth. Our analyses suggest there is, or at least has been in the recent past, institutional racism against Māori in New Zealand's home lending industry based on merely appearing more Māori.

  15. Neoliberalism and indigenous knowledge: Māori health research and the cultural politics of New Zealand's "National Science Challenges".

    Science.gov (United States)

    Prussing, Erica; Newbury, Elizabeth

    2016-02-01

    In 2012-13 the Ministry of Business, Innovation and Employment (MBIE) in New Zealand rapidly implemented a major restructuring of national scientific research funding. The "National Science Challenges" (NSC) initiative aims to promote greater commercial applications of scientific knowledge, reflecting ongoing neoliberal reforms in New Zealand. Using the example of health research, we examine the NSC as a key moment in ongoing indigenous Māori advocacy against neoliberalization. NSC rhetoric and practice through 2013 moved to marginalize participation by Māori researchers, in part through constructing "Māori" and "science" as essentially separate arenas-yet at the same time appeared to recognize and value culturally distinctive forms of Māori knowledge. To contest this "neoliberal multiculturalism," Māori health researchers reasserted the validity of culturally distinctive knowledge, strategically appropriated NSC rhetoric, and marshalled political resources to protect Māori research infrastructure. By foregrounding scientific knowledge production as an arena of contestation over neoliberal values and priorities, and attending closely to how neoliberalizing tactics can include moves to acknowledge cultural diversity, this analysis poses new questions for social scientific study of global trends toward reconfiguring the production of knowledge about health. Study findings are drawn from textual analysis of MBIE documents about the NSC from 2012 to 2014, materials circulated by Māori researchers in the blogosphere in 2014, and ethnographic interviews conducted in 2013 with 17 Māori health researchers working at 7 sites that included university-based research centers, government agencies, and independent consultancies.

  16. rctB mutations that increase copy number of Vibrio cholerae oriCII in Escherichia coli

    DEFF Research Database (Denmark)

    Koch, Birgit; Ma, Xiaofang; Løbner-Olesen, Anders

    2012-01-01

    RctB serves as the initiator protein for replication from oriCII, the origin of replication of Vibrio cholerae chromosome II. RctB is conserved between members of Vibrionaceae but shows no homology to known replication initiator proteins and has no recognizable sequence motifs. We used an ori...

  17. ori experiences of aphasia therapy: "But I'm from Hauiti and we've got shags".

    Science.gov (United States)

    McLellan, Karen M; McCann, Clare M; Worrall, Linda E; Harwood, Matire L N

    2014-10-01

    This study explored Māori experiences of aphasia therapy, with a view to ascertaining what makes a service culturally safe as well as "accessible to and culturally appropriate for" Māori with aphasia and their whānau (extended family). Māori are the indigenous peoples of New Zealand. This study incorporated interpretive description (a qualitative methodology) within kaupapa Māori research (a Māori approach to research). In-depth semi-structured interviews were undertaken with 11 Māori with aphasia and 23 of their nominated whānau members. They reported a wide variety of experiences of aphasia therapy, in six themes: We're happy to do the work, but we can't do it alone; Relationship; Our worldview; The speech-language therapy setting; Aphasia resources; and Is this as good as it gets? While some Māori with aphasia reportedly received an accessible and culturally appropriate service, others did not. It is concluded that, for Māori with aphasia, a strong therapeutic relationship is central. The success of this relationship is shaped by the SLP's appreciation of the worldview of the person with aphasia and whānau, the setting of the therapy, and the resources used. Successful therapy will involve collaboration between clinician and whānau, and therapy resources that affirm the identity of the person with aphasia.

  18. Application of MLST and pilus gene sequence comparisons to investigate the population structures of Actinomyces naeslundii and Actinomyces oris

    NARCIS (Netherlands)

    Henssge, U.; Do, T.; Gilbert, S.C.; Cox, S.; Clark, D.; Wickström, C.; Ligtenberg, A.J.M.; Radford, D.R.; Beighton, D.

    2011-01-01

    Actinomyces naeslundii and Actinomyces oris are members of the oral biofilm. Their identification using 16S rRNA sequencing is problematic and better achieved by comparison of metG partial sequences. A. oris is more abundant and more frequently isolated than A. naeslundii. We used a multi-locus

  19. Photometric activity of UX orionis stars and related objects in the near infrared and optical: CO Ori, RR Tau, UX Ori, and VV Ser

    Science.gov (United States)

    Shenavrin, V. I.; Rostopchina-Shakhovskaya, A. N.; Grinin, V. P.; Demidova, T. V.; Shakhovskoi, D. N.; Belan, S. P.

    2016-08-01

    This paper continues a study of the photometric activity of UX Ori stars in the optical and near-infrared ( JHKLM bands) initiated in 2000. For comparison, the list of program stars contains two Herbig Ae stars that are photometrically quiet in the optical: MWC480 andHD179218. Fadings ofUXOri stars in the optical ( V band) due to sporadic increases of the circumstellar extinction are also observed in the infrared (IR), but with decreasing amplitude. Two stars, RR Tau and UX Ori, displayed photometric events when V -band fadings were accompanied by an increase in IR fluxes. Among the two Herbig Ae stars that are photometrically quiet in the optical, MWC 480 proved to be fairly active in the IR. Unlike the UX Ori stars, the variation amplitude of MWC 480 increases from the J band to the M band. In the course of the observations, no deep fadings in the IR bands were detected. This indicates that eclipses of the program stars have a local nature, and are due to extinction variations in the innermost regions of the circumstellar disks. The results presented testify to an important role of the alignment of the circumstellar disks relative to the direction towards the observer in determining the observed IR variability of young stars.

  20. 5-FU-hydrogel inhibits colorectal peritoneal carcinomatosis and tumor growth in mice

    Directory of Open Access Journals (Sweden)

    Shi Huashan

    2010-08-01

    Full Text Available Abstract Background Colorectal peritoneal carcinomatosis (CRPC is a common form of systemic metastasis of intra-abdominal cancers. Intraperitoneal chemotherapy is a preferable option for colorectal cancer. Here we reported that a new system, 5-FU-loaded hydrogel system, can improve the therapeutic effects of intraperitoneal chemotherapy. Methods A biodegradable PEG-PCL-PEG (PECE triblock copolymer was successfully synthesized. The biodegradable and temperature sensitive hydrogel was developed to load 5-FU. Methylene blue-loaded hydrogel were also developed for visible observation of the drug release. The effects and toxicity of the 5-FU-hydrogel system were evaluated in a murine CRPC model. Results The hydrogel system is an injectable flowing solution at ambient temperature and forms a non-flowing gel depot at physiological temperature. 5-FU-hydrogel was subsequently injected into abdominal cavity in mice with CT26 cancer cells peritoneal dissemination. The results showed that the hydrogel delivery system prolonged the release of methylene blue; the 5-FU-hydrogel significantly inhibited the peritoneal dissemination and growth of CT26 cells. Furthermore, intraperitoneal administration of the 5-FU-hydrogel was well tolerated and showed less hematologic toxicity. Conclusions Our data indicate that the 5-FU-hydrogel system can be considered as a new strategy for peritoneal carcinomatosis, and the hydrogel may provide a potential delivery system to load different chemotherapeutic drugs for peritoneal carcinomatosis of cancers.

  1. Inhibitory effect of silibinin combined with 5-FU treatment on malignant biological behaviors of gastric cancer cell lines MGC803

    Institute of Scientific and Technical Information of China (English)

    Yang Wang; Chang-Lin Li

    2016-01-01

    Objective:To study the inhibitory effect of silibinin combined with 5-FU treatment on malignant biological behaviors of gastric cancer cell lines MGC803.Methods:Gastric cancer cell lines MGC803 were cultured, divided into NC group, 5-Fu group and SB+5-Fu group and treated with different conditions, and then the number of apoptotic cells, the number of invasive cells as well as the expression of proliferation and invasion-related genes were detected.Results:At 6 h, 12 h, 18 h and 24 h after treatment, the number of apoptotic cells of 5-Fu group and SB+5-Fu group was significantly more than that of NC group, the number of invasive cells was significantly less than that of NC group, the number of apoptotic cells of SB+5-Fu group was significantly more than that of 5-Fu group, and the number of invasive cells was significantly less than that of 5-Fu group; mRNA contents of Vav3, PTP1B, GOLPH3, RUNX3, Sipa1, UbcH10, NEDD9, Mig-7, CD157, AEP and Galectin-1 of 5-Fu group and SB+5-Fu group were lower than those of NC group; mRNA contents of Vav3, PTP1B, GOLPH3, UbcH10, NEDD9, Mig-7, CD157, AEP and Galectin-1 of SB+5-Fu group were lower than those of 5-Fu group, and mRNA contents of RUNX3 and Sipa1 were not different from those of 5-Fu group. Conclusion:Compared with single 5-FU treatment, silibinin combined with 5-FU treatment can more effectively promote gastric cancer cell apoptosis, inhibit gastric cancer cell invasion and regulate the expression of proliferation and invasion-related genes.

  2. A star forming ring around Kappa Ori 250 pc from the Sun

    CERN Document Server

    Pillitteri, I; Megeath, S T

    2016-01-01

    X-rays are a powerful probe of activity in early stages of star formation. They allow us to identify young stars even after they have lost the IR signatures of circumstellar disks and provide constraints on their distance. Here we report on XMM-Newton observations which detect 121 young stellar objects (YSOs) in two fields between L1641S and $\\kappa$ Ori. These observations extend the Survey of Orion A with XMM and Spitzer (SOXS). The YSOs are contained in a ring of gas and dust apparent at millimeter wavelengths, and in far-IR and near-IR surveys. The X-ray luminosity function of the young stellar objects detected in the two fields indicates a distance of 250-280 pc, much closer than the Orion A cloud and similar to distance estimates of $\\kappa$ Ori. We propose that the ring is a 5-8 pc diameter shell that has been swept up by $\\kappa$ Ori. This ring contains several groups of stars detected by Spitzer and WISE including one surrounding the Herbig Ae/Be stars V1818 Ori. In this interpretation, the $\\kappa$ ...

  3. Indigenous Māori perspectives on urban transport patterns linked to health and wellbeing.

    Science.gov (United States)

    Raerino Ngāti Awa Te Arawa, K; Macmillan, Alex K; Jones Ngāti Kahungunu, Rhys G

    2013-09-01

    There is a growing body of research linking urban transport systems to inequities in health. However, there is a lack of research providing evidence of the effect of transport systems on indigenous family wellbeing. We examined the connections between urban transport and the health and wellbeing of Māori, the indigenous people of New Zealand. We provide an indigenous exploration of current urban transport systems, with a particular focus on the impacts of car dependence and the need for culturally relevant travel. We interviewed nineteen Māori participants utilising qualitative research techniques underpinned by an indigenous research methodology (Kaupapa Māori). The data highlighted the importance of accessing cultural activities and sites relevant to 'being Māori', and issues with affordability and safety of public transport. Understanding the relationship between indigenous wellbeing and transport systems that goes further than limited discourses of inequity is essential to improving transport for indigenous wellbeing. Providing an indigenous voice in transport decision-making will make it more likely that indigenous health and wellbeing is prioritised in transport planning.

  4. 42 CFR 93.217 - Office of Research Integrity or ORI.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Office of Research Integrity or ORI. 93.217 Section 93.217 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH...

  5. Orbital and physical properties of the $\\sigma$ Ori Aa,Ab,B triple system

    CERN Document Server

    Simón-Díaz,; Lorenzo, J; Apellániz, J Maíz; Schneider, F R N; Negueruela, I; Barbá, R H; Dorda, R; Marco, A; Montes, D; Pellerin, A; Sanchez-Bermudez, J; Sódor, Á; Sota, A

    2014-01-01

    We provide a complete characterization of the astrophysical properties of the $\\sigma$ Ori Aa,Ab,B hierarchical triple system, and an improved set of orbital parameters for the highly eccentric $\\sigma$ Ori Aa,Ab spectroscopic binary. We compiled a spectroscopic dataset comprising 90 high-resolution spectra covering a total time span of 1963 days. We applied the Lehman-Filh\\'es method for a detailed orbital analysis of the radial velocity curves and performed a combined quantitative spectroscopic analysis of the {$\\sigma$ Ori Aa,Ab,B} system by means of the stellar atmosphere code FASTWIND. We used our own plus other available information on photometry and distance to the system for measuring the radii, luminosities, and spectroscopic masses of the three components. We also inferred evolutionary masses and stellar ages using the Bayesian code BONNSAI. The orbital analysis of the new radial velocity curves led to a very accurate orbital solution of the $\\sigma$ Ori Aa,Ab pair. We provided indirect arguments in...

  6. Dynamisch-optische Oberflächenvermessung des plantaren Fußes

    OpenAIRE

    Schmeltzpfenning, Timo

    2011-01-01

    Dynamisch-optische Oberflächenvermessung des plantaren Fußes Inhalt und Vorgehensweise Die Entwicklung eines zeitauflösenden dreidimensionalen Fußscanners unter Verwendung einer dynamisch-optischen Oberflächenvermessung stellt die primäre Zielsetzung dar. Dieses System wurde anschließend genutzt, um erste Erkenntnisse zur dynamischen Fußformveränderung über den Abrollvorgang zu gewinnen. Die Relevanz der Formveränderung, z.B. für die industrielle Schuhfertigung, wird in der Arbeit...

  7. Identification of ALV-J associated acutely transforming virus Fu-J carrying complete v-fps oncogene.

    Science.gov (United States)

    Wang, Yixin; Li, Jianliang; Li, Yang; Fang, Lichun; Sun, Xiaolong; Chang, Shuang; Zhao, Peng; Cui, Zhizhong

    2016-06-01

    Transduction of oncogenes by ALVs and generation of acute transforming viruses is common in natural viral infections. In order to understand the molecular basis for the rapid oncogenicity of Fu-J, an acutely transforming avian leukosis virus isolated from fibrosarcomas in crossbreed broilers infected with subgroup J avian leukosis virus (ALV-J) in China, complete genomic structure of Fu-J virus was determined by PCR amplification and compared with those of Fu-J1, Fu-J2, Fu-J3, Fu-J4, and Fu-J5 reported previously. The results showed that the genome of Fu-J was defective, with parts of gag gene replaced by the complete v-fps oncogene and encoded a 137 kDa Gag-fps fusion protein. Sequence analysis revealed that Fu-J and Fu-J1 to Fu-J5 were related quasi-species variants carrying different lengths of v-fps oncogenes generated from recombination between helper virus and c-fps gene. Comparison of virus carrying v-fps oncogene also gave us a glimpse of the molecular characterization and evolution process of the acutely transforming ALV.

  8. Antioxidants decrease the apoptotic effect of 5-Fu in colon cancer by regulating Src-dependent caspase-7 phosphorylation

    Science.gov (United States)

    Fu, Y; Yang, G; Zhu, F; Peng, C; Li, W; Li, H; Kim, H-G; Bode, A M; Dong, Z; Dong, Z

    2014-01-01

    Although the rate of development of drug resistance remains very high, 5-fluorouracil (5-Fu) is still the most common chemotherapeutic drug used for the treatment of colon cancer. A better understanding of the mechanism of why cancers develop resistance to 5-Fu could improve its therapeutic effect. Sometimes, antioxidants are used simultaneously with 5-Fu treatment. However, a recent clinical trial showed no advantage or even a harmful effect of combining antioxidants with 5-Fu compared with administration of 5-Fu alone. The mechanism explaining this phenomenon is still poorly understood. In this study, we show that 5-Fu can induce reactive oxygen species-dependent Src activation in colon cancer cells. Mouse embryonic fibroblasts that are deficient in Src showed a clear resistance to 5-Fu, and knocking down Src protein expression in colon cancer cells also decreased 5-Fu-induced apoptosis. We found that Src could interact with and phosphorylate caspase-7 at multiple tyrosine sites. Functionally, the tyrosine phosphorylation of caspase-7 increases its activity, thereby enhancing cellular apoptosis. When using 5-Fu and antioxidants together, Src activation was blocked, resulting in decreased 5-Fu-induced apoptosis. Our results provide a novel explanation as to why 5-Fu is not effective in combination with some antioxidants in colon cancer patients, which is important for clinical chemotherapy. PMID:24407236

  9. The effectiveness of television advertising campaigns on generating calls to a national Quitline by Māori.

    Science.gov (United States)

    Wilson, N; Grigg, M; Graham, L; Cameron, G

    2005-08-01

    To examine the effectiveness of four mass media campaigns on calls to a national Quitline by Māori (the indigenous people of New Zealand). Monthly Quitline call data and calls within one hour of a television commercial (TVC) being shown were analysed for the 2002-2003 period. Data on target audience rating points (TARPs) and expenditure on TVCs were also used (n = 2319 TVC placements). Māori were found to register with the Quitline at higher rates during the most intense six campaign months (15% more registrations compared to less intense months). The most effective campaign generated 115 calls per 100 TARPs by Māori callers within one hour of TVC airing (the "Every cigarette" campaign). A more Māori orientated campaign with both health and cultural themes generated 91 calls per 100 TARPs from Māori callers. For these two campaigns combined, the advertising cost per new registration with the Quitline by a Māori caller was NZD 30-48. Two second hand smoke campaigns that did not show the Quitline number were much less effective at 25 and 45 calls per 100 TARPs. These television advertising campaigns were effective and cost effective in generating calls to a national Quitline by Māori. Health authorities should continue to explore the use of both "threat appeal" style media campaigns and culturally appropriate campaigns to support Quitline use by indigenous peoples.

  10. NE TIGER Premieres New Hua Fu At Bird’s Nest

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    On the evening of September 25, China’s leading luxury fashion brand NE TIGER presented its premiere fashion show of Hua Fu(Chinese national dress) at a concert of superstars from China, Japan and South Korea,

  11. [Professor Xu Fu-song's traditional Chinese medicine protocols for male diseases: A descriptive analysis].

    Science.gov (United States)

    Liu, Cheng-yong; Xu, Fu-song

    2015-04-01

    To analyze the efficacy and medication principles of Professor Xu Fu-songs traditional Chinese medicine (TCM) protocols for male diseases. We reviewed and descriptively analyzed the unpublished complete medical records of 100 male cases treated by Professor Xu Fu-song with his TCM protocols from 1978 to 1992. The 100 cases involved 32 male diseases, most of which were difficult and complicated cases. The drug compliance was 95%. Each prescription was made up of 14 traditional Chinese drugs on average. The cure rate was 32% , and the effective rate was 85%. Professor Xu Fu-song advanced and proved some new theories and therapeutic methods. Professor Xu Fu-song's TCM protocols can be applied to a wide range of male diseases, mostly complicated, and are characterized by accurate differentiation of symptoms and signs, high drug compliance, and excellent therapeutic efficacy.

  12. Asynchronous Sensor fuSion for Improved Safety of air Traffic (ASSIST) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — SSCI proposes to develop, implement and test a collision detection system for unmanned aerial vehicles (UAV), referred to as the Asynchronous Sensor fuSion for...

  13. 5FU and oxaliplatin-containing chemotherapy in two dihydropyrimidine dehydrogenase-deficient patients.

    Science.gov (United States)

    Reerink, O; Mulder, N H; Szabo, B G; Hospers, G A P

    2004-01-01

    Patients with a germline mutation leading to a deficiency of the dihydropyrimidine dehydrogenase (DPD) enzyme are at risk from developing severe toxicity on the administration of 5FU-containing chemotherapy. We report on the implications of this inborn genetic error in two patients who received 5FU and oxaliplatin. A possible co-medication effect of oxaliplatin is considered, as are the consequences of screening for DPD deficiency.

  14. [Coma following chemotherapy: is 5FU implicated? Discussion about on case-report].

    Science.gov (United States)

    Heluwaert, Frédéric; Santre, Charles; Martin, Claude; Hilleret, Marie-Noëlle; Martin, Denis

    2006-02-01

    5FU is one of the most frequently used antioncogenic and cytostatic drug in digestive oncology. It may cause severe adverse events, such as encephalopathy, possibly based on hyperammoniemia, and may lead to coma. We report here the case of a coma with a favorable outcome following 5FU chemotherapy. As any other etiologic findings came to light, hyperammoniemia was discussed as a credible cause.

  15. Zur Kulturbedeutung von Hooligandiskurs und Alltagsrassismus im Fußballsport

    OpenAIRE

    2007-01-01

    'Dieser Essay diskutiert die Frage nach dem Sinnzusammenhang zwischen rechter Gewalt und Alltagsrassismus in der Fußballwelt. Es wird argumentiert, dass die Betonung des (marginalen) Phänomens des rechten Extremismus und seine Verknüpfung mit Rassismus und Hooliganismus den (weitverbreiteten) Rassismus in den niedrigen Amateurklassen verdeckt. Indem sie ihre moralische Abscheu vor dem Hooliganismus zum Ausdruck bringen, sind Angehörige der Fußballwelt dazu in der Lage, sich symbolisch vom All...

  16. Resistance of colorectal cancer cells to radiation and 5-FU is associated with MELK expression

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Seungho [Laboratory of Cell Biology, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799 (Korea, Republic of); Ku, Ja-Lok, E-mail: kujalok@snu.ac.kr [Laboratory of Cell Biology, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799 (Korea, Republic of)

    2011-08-26

    Highlights: {yields} MELK expression significantly increased when the cells are exposed to radiation or 5-FU. {yields} Suppression of MELK caused cell cycle changes and decrease in proliferation. {yields} Radiation or 5-FU treatment after MELK suppression by siRNA induced growth inhibition. -- Abstract: It was reported that the local recurrence would be caused by cancer stem cells acquiring chemo- and radio-resistance. Recently, one of the potential therapeutic targets for colorectal and other cancers has been identified, which is maternal embryonic leucine zipper kinase (MELK). MELK is known as an embryonic and neural stem cell marker, and associated with the cell survival, cell proliferation, and apoptosis. In this study, SNU-503, which is a rectal cancer cell line, was treated with radiation or 5-fluorouracil (5-FU), and elevation of the MELK expression level was observed. Furthermore, the cell line was pre-treated with small interfering RNA (siRNA) against MELK mRNA before treatment of radiation or 5-FU and its effects on cell cycle and proliferation were observed. We demonstrated that knockdown of MELK reduced the proliferation of cells with radiation or 5-FU treatment. In addition, MELK suppression caused changes in cell cycle. In conclusion, MELK could be associated with increased resistance of colorectal cancer cells against radiation and 5-FU.

  17. Tegafur Substitution for 5-Fu in Combination with Actinomycin D to Treat Gestational Trophoblastic Neoplasm.

    Directory of Open Access Journals (Sweden)

    Mei Peng

    Full Text Available Although 5-fluorouracil (5-Fu combination chemotherapy provides a satisfactory therapeutic response in patients with gestational trophoblastic neoplasms (GTNs, it has severe side effects. The current study analyzed the therapeutic effects and side effects of tegafur plus actinomycin D (Act-D vs. 5-Fu plus Act-D for the treatment of GTNs based on controlled historical records. A total of 427 GTN cases that received tegafur and Act-D combination chemotherapy at the Second Xiangya Hospital of XiangYa Medical School between August 2003 and July 2013 were analyzed based on historical data. A total of 393 GTN cases that received 5-Fu plus Act-D between August 1993 and July 2003 at the same hospital were also analyzed, which constituted the control group. The therapeutic effects, toxicity and side effects after chemotherapy were compared between the groups. The overall response rate was 90.63% in the tegafur+Act-D group (tegafur group and 92.37% in the 5-Fu+Act-D group (5-Fu group; these rates were not significantly different (P > 0.05. However, the incidence rates of myelosuppression (white blood cell decline, gastrointestinal reactions (nausea, vomiting, dental ulcer, and diarrhea, skin lesions and phlebitis were lower in the tegafur group than in the 5-Fu group (P < 0.05. The results of this study may provide useful data for the clinical application of tegafur in GTN treatment.

  18. Enhanced DNA-directed effects of FdUMP[10] compared to 5FU.

    Science.gov (United States)

    Gmeiner, William H; Trump, Eric; Wei, Cui

    2004-01-01

    FdUMP[N] molecules and conjugates are much more effective at inhibiting the proliferation of human tumor cells than is the widely used anticancer drug 5-fluorouracil (5FU). We have evaluated the inhibition of thymidylate synthase (TS), the extent of DNA damage, cell cycle arrest, and the induction of apoptosis by FdUMP[10] and 5FU in the human colorectal cancer cell line HT29. The magnitude and duration of TS inhibition following exposure of HT29 cells to FdUMP[10] at 1 x 10(-8) M was greater than that which occurred following exposure of these cells to 5FU at 1 x 10(-6) M. FdUMP[10] exposure also resulted in much more extensive DNA damage to HT29 cells than occurred following exposure to 100-fold higher concentrations of 5FU. Although exposure of HT29 cells to both drugs resulted in S-phase arrest, more complete accumulation of cells in S-phase was achieved following FdUMP[10] exposure at much lower drug concentrations. FdUMP[10] was also much more effective at inducing apoptosis in HT29 cells than was 5FU. The results are consistent with FdUMP[10] being much more efficient that 5FU at inducing DNA damage that results in apoptotic cell death in colon cancer cells.

  19. Up-regulation of insulin-like growth factor-binding protein 3 by 5-fluorouracil (5-FU) leads to the potent anti-proliferative effect of androgen deprivation therapy combined with 5-FU in human prostate cancer cell lines.

    Science.gov (United States)

    Kawabata, Rumi; Oie, Shinji; Takahashi, Masayuki; Kanayama, Hiroomi; Oka, Toshinori; Itoh, Kohji

    2011-06-01

    In this study, we investigated the synergistic mechanism of anti-androgen and 5-fluorouracil (5-FU) combination therapy against castration-resistant prostate cancer (CRPC). Four prostate cancer cell lines, LNCaP, 22Rv1, DU145 and PC3, were examined for their growth dependency on androgens and the insulin-like growth factor 1 (IGF1). We assessed the expression changes of certain growth factor receptors and regulating proteins when treated with 5-FU, and found that 5-FU increased the expression of the IGF-binding protein 3 (IGFBP3). Furthermore, 5-FU inhibited the phosphorylation of Akt and p70 S6K, while the knockdown of IGFBP3 reduced the levels of poly (ADP-ribose) polymerase cleaved by 5-FU in PC3 cells. Therefore, the up-regulation of IGFBP3 by 5-FU not only inhibits cell growth by reducing the IGF1 signal but also induces apoptosis in PC3 cells. The synergistic effect of bicalutamide and 5-FU on 22Rv1 cells was reduced by IGFBP3 gene silencing using small-interfering RNA. These results suggest that the up-regulation of IGFBP3 induced by 5-FU plays an important role in the potent anti-tumor effect of 5-FU combined with anti-androgens on CRPC. Androgen-deprivation therapy combined with 5-FU could therefore be an appropriate therapy for CRPC patients.

  20. Provider, father, and bro--Sedentary Māori men and their thoughts on physical activity.

    Science.gov (United States)

    Warbrick, Isaac; Wilson, Denise; Boulton, Amohia

    2016-02-04

    ori (indigenous peoples of New Zealand) men have a disproportionate prevalence of lifestyle-related illnesses and are targeted for national physical activity initiatives. While physical activity impacts on physical and mental health and overall wellbeing, current approaches to health promotion often lack cultural relevance. Having better understanding and incorporating relevant cultural values and motivators into program designs could improve the success of health initiatives for indigenous and minority men. Nevertheless, little is known about Māori men's preferences, attitudes, or perspectives about physical activity, which are often interpreted through a colonized or dominant Western lens. Understanding perspectives of those groups whose values do not align with dominant cultural approaches will better equip health promoters and trainers to develop relevant community initiatives and private programs for indigenous and minority men. An indigenous research approach informed a qualitative study with 18 sedentary, 'overweight' Māori men aged 28 to 72 years. From 2014 to 2015 these men participated in three focus group discussions aimed at understanding their views about physical activity and exercise. Data were thematically analysed and interpeted using a Māori worldview. Four key themes were identified - Cameraderie and 'Bro-ship'; Adulthood Distractions and Priorities; Problems with Contemporary Gym Culture; and Provider Orientation. Key motivators for physical activity included a sense of 'brotherhood' in sport and physical activity and accountability to others. Participants reported the need to highlight the value of people and relationships, and having an orientation to the collective to enhance physical activity experiences for Māori men in general. Modern lifestyle distractions (such as being time deficient, and family responsibilities) along with other priorities contributed to difficulties incorporating physical activity into their daily lives. In

  1. In vivo biodistribution for tumor targeting of 5-fluorouracil (5-FU) loaded N-succinyl-chitosan (Suc-Chi) nanoparticles.

    Science.gov (United States)

    Yan, Chengyun; Gu, Jiwei; Guo, Yuzhi; Chen, Dawei

    2010-06-01

    5-Fluorouracil-loaded N-succinyl-chitosan nanoparticles (5-FU-Suc-Chi/NP) were prepared by emulsification solvent diffusion. Biodistribution and tumor targeting were evaluated after i.v. administration of 5-Fu-Suc-Chi/NPs in Sarcoma 180-bearing mice. Also, pharmacokinetic profiles were evaluated after intravenous injection of 5-Fu-Suc-Chi/NP via the tail vein to rats. Our experimental results showed the 5-FU-Suc-Chi/NPs could be sustained at a high level in the blood for a very long time, implying its long systemic retention in the circulation. 5-FU-Suc-Chi/NPs were distributed mainly in tumors and liver, with small quantities being found in kidney and spleen. 5-FU-Suc-Chi/NPs accumulated only slightly in the heart and lung, and lowered the toxic effect of 5-FU in the heart and lung. Pharmacokinetic analysis in plasma showed the area under plasma concentration-time curve (AUC), elimination half-life (t(1/2)), and residence time (MRT) were increased 2.5-fold, 10.98-fold, and 10.8-fold for 5-FU-Suc-Chi/NP compared with that of free 5-FU, respectively. These results indicate that a long half-life in the circulation and tumor targeting of 5-FU-Suc-Chi/NPs are possible.

  2. 5-fluorouracil (5FU) treatment does not influence invasion and metastasis in microsatellite unstable (MSI-H) colorectal cancer.

    Science.gov (United States)

    Warusavitarne, Janindra; Ramanathan, Palaniappan; Kaufman, Anthony; Robinson, Bruce G; Schnitzler, Margaret

    2006-10-01

    Microsatellite instability is a recognised pathway of colorectal carcinogenesis responsible for about 15% of all sporadic colorectal cancers. Recent evidence has suggested that these tumours may not have the same response as microsatellite stable colon cancers to 5-fluorouracil (5FU)-based chemotherapy. The response to 5FU in four microsatellite unstable (MSI-H) cell lines was examined by cell viability assays and invasion assays. Flow cytometry was used to assess the effect of 5FU on MSI-H cell lines. In vivo response to 5FU was assessed by intraperitoneal injection of 5FU or control to 80 nude mice that had received intrasplenic injections of an MSI-H cell line KM12C prior to commencing treatment. There was inhibition of cell growth in MSI-H cell lines when treated with 5FU. There was no difference in invasiveness in the MSI-H cell lines when treated with 5FU. Primary tumours formed in 27 of the untreated and 25 of the 5FU treated mice (p=NS). There was a 36% reduction in splenic weight in those mice treated with 5FU (p5FU treatment of MSI-H tumours results in a reduction in growth but does not result in a reduction in invasion or metastasis.

  3. Wild type p53 increased chemosensitivity of drug-resistant human hepatocellular carcinoma Be17402 / 5-FU cells

    Institute of Scientific and Technical Information of China (English)

    Yu-xiuLI; Zhi-binLIN; Huan-ranTAN

    2004-01-01

    AIM: To study the effect of wild type (wt) p53 gene transfection on drug resistant human hepatocellular carcinoma(HCC) cells induced by 5-Fluorouracil (5-FU). METHODS: The cytotoxicity of anticancer drugs on Be17402 and Be17402/5-FU cells was assessed using SRB assay, p53 expression was detected at its mRNA level by RT-PCR assay and at its protein level Western blot or immunocytochemistry assay in Be17402/5-FU cells transfected with either control vector or wt p53. AnnexinV-FITC/PI double labeled assay was performed to detect apoptosis. The chemosensitivity of Be17402/5-FU cells transfected with wt p53 was assessed using SRB assay. RESULTS: Be17402/5-FU cells exhibited cross-resistance to vincristine, doxorubicin, paclitaxel, and so on. wt p53 gene transfection upregulated the expression of p53 in Be17402/5-FU cells, wt p53 was able to greatly inhibit cell proliferation and significantly induce apoptosis in Be17402/5-FU cells. Moreover, wt p53 gene transfection increased the chemosensitivity of Be17402/5-FU cells to some anticancer drugs. CONCLUSION: These results indicated that the wt p53 gene transfection not only induced suppression of cell growth, but also increased the sensitivity of Be17402/5-FU cells to 5-FU, vincristine, and doxorubicin.

  4. Phase III study of 5FU, etoposide and leucovorin (FELV) compared to epirubicin, cisplatin and 5FU (ECF) in previously untreated patients with advanced biliary cancer.

    Science.gov (United States)

    Rao, S; Cunningham, D; Hawkins, R E; Hill, M E; Smith, D; Daniel, F; Ross, P J; Oates, J; Norman, A R

    2005-05-09

    The purpose of this study was to determine whether epirubicin, cisplatin and infused 5FU (ECF) improves overall survival (OS) compared to 5FU, etoposide and leucovorin (FELV) in patients with previously untreated advanced biliary cancer in a prospective randomised study. Patients were randomly assigned to receive epirubicin, cisplatin and infused 5FU ECF or bolus 5FU etoposide and leucovorin (FELV). The primary end point was OS with secondary end points of objective response rate (ORR), failure-free survival (FFS), quality of life (QOL) and toxicity. In all, 54 patients were recruited with 27 randomly assigned to each arm. The median OS for ECF was 9.02 months (95% confidence interval (CI): 6.46-11.51) and FELV 12.03 months (95% CI: 9.3-14.7), P=0.2059. Objective response rates were similar for both arms: ECF 19.2% (95% CI: 6.55-39.3); FELV 15% (95% CI: 3.2-37.9), P=0.72. There was significantly increased grade 3/4 neutropenia with FELV vs ECF (53.8 vs 29.5%, respectively, P=0.020). Symptom resolution was impressive for both regimens. This is the largest reported randomised study to date in this setting. ECF did not improve OS compared to FELV, but was associated with less acute toxicity. These data suggest that chemotherapy can prolong OS and achieve good symptomatic relief in advanced biliary cancer.

  5. MOST Observations of sigma Ori E: Challenging the Centrifugal Breakout Narrative

    CERN Document Server

    Townsend, R H D; Rowe, J F; Moffat, A F J; Matthews, J M; Bohlender, D; Neiner, C; Telting, J H; Guenther, D B; Kallinger, T; Kuschnig, R; Rucinski, S M; Sasselov, D; Weiss, W W

    2013-01-01

    We present results from three weeks' photometric monitoring of the magnetic helium-strong star sigma Ori E using the MOST microsatellite. The star's light curve is dominated by twice-per-rotation eclipse-like dimmings arising when magnetospheric clouds transit across and occult the stellar disk. However, no evidence is found for any abrupt centrifugal breakout of plasma from the magnetosphere, either in the residual flux or in the depths of the light minima. Motivated by this finding we compare the observationally inferred magnetospheric mass against that predicted by a breakout analysis. The large discrepancy between the values leads us to argue that centrifugal breakout does not play a significant role in establishing the magnetospheric mass budget of sigma Ori E.

  6. La consécration par la théorie

    Directory of Open Access Journals (Sweden)

    François Provenzano

    2010-06-01

    Full Text Available Il ne sera pas question ici de proposer une théorie de la consécration, mais bien de questionner les effets de consécration que produit la théorie littéraire elle-même, en tant que formation discursive qui participerait au travail de négociation et de transaction de valeurs qui définit le jeu littéraire et structure les unités qui le composent. Notre propos ne sera donc pas tant d’objectiver ou de modéliser un processus de consécration, mais bien de mettre en évidence le pouvoir de consécrati...

  7. L’évolution de la théorie du droit (1970-2010)

    OpenAIRE

    TROPER, Michel

    2016-01-01

    Le titre qui m’a été suggéré pour cet exposé n’est précis qu’en apparence. Si le début et la fin de la période à étudier sont clairement définis, il subsiste une double ambiguïté. En premier lieu, il pourrait s’agir de l’histoire de la théorie du droit en France seulement, ou plus largement dans le monde. D’autre part, la théorie du droit a été et est encore tantôt une discipline qui entend se distinguer radicalement de la philosophie du droit, tantôt une autre dénomination de la philosophie ...

  8. Narratives and traits in personality development among New Zealand Māori, Chinese, and European adolescents.

    Science.gov (United States)

    Reese, Elaine; Chen, Yan; McAnally, Helena M; Myftari, Ella; Neha, Tia; Wang, Qi; Jack, Fiona

    2014-07-01

    Narrative and trait levels of personality were assessed in a sample of 268 adolescents from age 12 to 21 from New Zealand Māori, Chinese, and European cultures. Adolescents narrated three critical events and completed a Big Five personality inventory. Each narrative was coded for causal and thematic coherence. NZ Chinese adolescents reported lower levels of extraversion, agreeableness, conscientiousness, and openness, and higher levels of neuroticism, than NZ Māori or European adolescents. Cultural differences were also evident in narrative coherence. Adolescents in all three groups demonstrated age-related increases in thematic coherence, but only NZ European adolescents demonstrated the expected age-related increases in causal coherence. Narrative identity and traits were distinct aspects of personality for younger adolescents, but were linked for middle and older adolescents. These findings support the importance of both narrative identity and traits in understanding personality development in adolescents across cultures.

  9. Revisiting the Rigidly Rotating Magnetosphere model for sigma Ori E. I. Observations and Data Analysis

    CERN Document Server

    Oksala, M E; Townsend, R H D; Owocki, S P; Kochukhov, O; Neiner, C; Alecian, E; Grunhut, J

    2011-01-01

    We have obtained 18 new high-resolution spectropolarimetric observations of the B2Vp star sigma Ori E with both the Narval and ESPaDOnS spectropolarimeters. The aim of these observations is to test, with modern data, the assumptions of the Rigidly Rotating Magnetosphere (RRM) model of Townsend & Owocki (2005), applied to the specific case of sigma Ori E by Townsend et al. (2005). This model includes a substantially offset dipole magnetic field configuration, and approximately reproduces previous observational variations in longitudinal field strength, photometric brightness, and Halpha emission. We analyze new spectroscopy, including H I, He I, C II, Si III and Fe III lines, confirming the diversity of variability in photospheric lines, as well as the double S-wave variation of circumstellar hydrogen. Using the multiline analysis method of Least-Squares Deconvolution (LSD), new, more precise longitudinal magnetic field measurements reveal a substantial variance between the shapes of the observed and RRM m...

  10. Une introduction aux liens entre Mécanique Statistique et Théorie des champs.

    OpenAIRE

    Bauer, Michel

    2006-01-01

    Avant propos.1 - Transitions de phases et limite continue. -A. Introduction -B. Notion de limite continue : marche aléatoire sur le réseau -C. Le modéle d'Ising en dimension 2 -D. Perspectives 2 - Phénomènes critique et théories des champs sur le résau -A. Retour au modéle d'Ising -B. Champ moyen et corrections -C. Régles de Feynman -D. Interprétation physique dans le cas homogéne -E. Le modélesigma non linéaire -F. Passage à la limite continue 3 - Théorie des champs continue -A. Régles de Fe...

  11. L'effet Casimir : théorie et expériences

    Science.gov (United States)

    Lambrecht, A.; Genet, C.; Intravaia, F.; Reynaud, S.

    2004-11-01

    L'existence de fluctuations irréductibles de champ dans le vide est une prédiction importante de la théorie quantique. Ces fluctuations ont de nombreuses conséquences observables comme l'effet Casimir, qui est maintenant mesuré avec une bonne précision et un bon accord avec la théorie, pourvu que celle-ci tienne compte des différences entre les expériences rélles et la situation idéale considérée par H.G.B. Casimir. Nous présenterons quelqu'unes des expériences récentes et discuterons les principales corrections à la force de Casimir liées à la situation expérimentale.

  12. MOST OBSERVATIONS OF {sigma} Ori E: CHALLENGING THE CENTRIFUGAL BREAKOUT NARRATIVE

    Energy Technology Data Exchange (ETDEWEB)

    Townsend, R. H. D. [Department of Astronomy, University of Wisconsin-Madison, 2535 Sterling Hall, 475 N. Charter Street, Madison, WI 53706 (United States); Rivinius, Th. [ESO-European Organisation for Astronomical Research in the Southern Hemisphere, Casilla 19001, Santiago 19 (Chile); Rowe, J. F. [NASA Ames Research Center, Moffett Field, CA 94035 (United States); Moffat, A. F. J. [Department de physique, Universite de Montreal C.P. 6128, Succursale Centre-Ville, Montreal, QC H3C 3J7 (Canada); Matthews, J. M.; Kallinger, T.; Kuschnig, R. [Department of Physics and Astronomy, University of British Columbia, 6224 Agricultural Road, Vancouver, BC V6T 1Z1 (Canada); Bohlender, D. [National Research Council of Canada, Herzberg Institue of Astrophysics, 5071 West Saanich Road, Victoria, BC V9E 2E7 (Canada); Neiner, C. [LESIA, UMR 8109 du CNRS, Observatoire de Paris, UPMC, Universite Paris Diderot, 5 place Jules Janssen, 92195 Meudon Cedex (France); Telting, J. H. [Nordic Optical Telescope, Apartado 474, 38700 Santa Cruze de La Palma (Spain); Guenther, D. B. [Department of Astronomy and Physics, St. Marys University, Halifax, NS B3H 3C3 (Canada); Rucinski, S. M. [Department of Astronomy and Astrophysics, University of Toronto, 50 St George Street, Toronto, ON M5S 3H4 (Canada); Sasselov, D. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Weiss, W. W., E-mail: townsend@astro.wisc.edu [Institute for Astronomy, University of Vienna, Tuerkenschanzstrasse 17, A-1180 Vienna (Austria)

    2013-05-20

    We present results from three weeks' photometric monitoring of the magnetic helium-strong star {sigma} Ori E using the Microvariability and Oscillations of Stars microsatellite. The star's light curve is dominated by twice-per-rotation eclipse-like dimmings arising when magnetospheric clouds transit across and occult the stellar disk. However, no evidence is found for any abrupt centrifugal breakout of plasma from the magnetosphere, either in the residual flux or in the depths of the light minima. Motivated by this finding we compare the observationally inferred magnetospheric mass against that predicted by a breakout analysis. The large discrepancy between the values leads us to argue that centrifugal breakout does not play a significant role in establishing the magnetospheric mass budget of {sigma} Ori E.

  13. Climate change and the right to health for Māori in Aotearoa/New Zealand.

    Science.gov (United States)

    Jones, Rhys; Bennett, Hayley; Keating, Gay; Blaiklock, Alison

    2014-06-14

    Climate change is widely regarded as one of the most serious global health threats of the 21st century. Its impacts will be disproportionately borne by the most disadvantaged populations, including indigenous peoples. For Māori in Aotearoa/New Zealand, as with other indigenous peoples worldwide, colonization has led to dispossession of land, destabilization of cultural foundations, and social, economic, and political marginalization. Climate change threatens to exacerbate these processes, adding future insult to historical and contemporary injury. Yet the challenges posed by climate change are accompanied by considerable opportunities to advance indigenous rights and reduce health disparities. In this paper, we examine issues related to climate change and Māori health using a right to health analytical framework, which identifies obligations for the New Zealand government.

  14. Language Image in National Minority Language Television Idents. TG4 (Teilifís na Gaeilge, Ireland and Whakaata Māori (Māori Television, New Zealand

    Directory of Open Access Journals (Sweden)

    Ruth Lysaght

    2009-03-01

    Full Text Available Born of community and political action, Teilifis na Gaeilge (TG4 began in 1996, and Whakaata Māori/ Māori Television Service (MTS in 2004. Despite obvious differences between the two broadcasting environments, both stations attempt to reclaim a national (but minority language (Ó Ruairc 1996; Moring 2007 and compete with other broadcasters (Horrocks and Perry 2004 to attract an audience (Smith and Abel 2008 by an appeal to identity (Cormack 2000; 2007; Delap 2007. This paper investigates idents from TG4 and MTS. What image or brand have the language and culture in these mini-advertisements? Thornley’s (2004 discussion of “transculturation” is useful in examining the often inventive approach taken to elements of the dominant culture. Indeed, the motto ‘Súil eile’ [another perspective] is the criterion for many TG4 projects, and there is a clear awareness of multiple audiences in the MTS logline, ‘mā mātou, mā rātou, mā koutou, mā tātou’ [just for us, for them, for all of you, for all of us]. In the symbiotic relationship between a minority station and other larger stations in terms of the depiction/creation of local and national identity, language is used as another marketing tool. TG4 and MTS idents respond to and celebrate current sociolinguistic changes (Romaine 2006; Ó Tuathaigh 2008, making them visible.

  15. Associations between orbicularis oris thickness and skeletal and dental variables in mixed dentition

    Directory of Open Access Journals (Sweden)

    Taís de Souza Barbosa

    Full Text Available AIM: To evaluate the association between orbicularis oris thickness and skeletal and dental variables in children with mixed dentition. MATERIAL AND METHOD: A convenience sample of 22 children, aged 7 to 12 years, with skeletal Class I and Class II malocclusion and subdivisions were selected. The upper and lower fascicles of the orbicularis oris thicknesses were measured using ultrasound (US by one calibrated examiner, at rest and in the contracted state. Cephalometric radiograph measurements of the hard and soft tissues were calculated by one trained examiner. The results were analyzed by the Pearson and Spearman coefficients. RESULT: The upper and lower fascicles of the orbicularis oris in the contracted state showed a negative correlation with the distance between Ricketts' E-line and the labrale superius (E ┴ Ls. There were positive correlations between the lower face height and the distance between the AB plane and the labrale superius (AB-Ls and between the ANB angle and the distance between E ┴ Ls and Ricketts' E-line and the labrale inferius (E ┴ Li. The lower-incisor distance from the N-Pg plane correlated positively with the distance between AB-Ls and the distance between the E ┴ Ls and E ┴ Li. Overbite and interincisal angle were negatively correlated with the distance between the pogonion and the soft tissue pogonion and the distance between E ┴ Li, respectively. CONCLUSION: Skeletal and dental variables were associated with upper and lower lip position and pogonion thickness, while the upper and lower fascicles of the orbicularis oris thicknesses in the contracted state were associated only with upper lip retrusion.

  16. Activité créatrice « transformationnelle » - Théorie et pratique.

    OpenAIRE

    Bel, Bernard; Bel, Andréine

    1990-01-01

    A theory of artistic creation by Kashmiri philosophers, and improvisatory composition techniques in North Indian classical (art) music shed light from a different angle on the role of memory and cognitive processes in artistic creation, thereby calling for a relativization of some statements regarding composition theory. This study addresses the debate about a discrepancy between "creativity" and "innovation".; Une théorie de l'oeuvre selon les philosophes cachemiriens, et les techniques d'im...

  17. Introduction à la théorie quantique concepts, pratiques et applications

    CERN Document Server

    Desouter, Michèle; Chapuisat, Xavier

    2017-01-01

    Introduction à la théorie quantique avec exercices corrigés pour les niveaux licence et master en physique, physico-chimie et chimie, permet d'atteindre une base solide en Mécanique Quantique et le niveau indispensable pour aborder les sujets multidisciplinaires de la recherche actuelle. En complément optionnel sur un site compagnon, des applications interactives.

  18. Schatgraven in 'de mijnen van het Oosten'. Europa's eerste tijdschrift voor oriëntaalse studies

    Directory of Open Access Journals (Sweden)

    Peter Rietbergen

    1999-06-01

    Full Text Available Tussen 1809 en 1818 verscheen Fundgruben des Orients. Dit eerste Europese tijdschrift voor oriëntaalse studies was een spreekbuis voor liefhebbers van de cultuur van het Oosten. De redactie wilde de nadruk leggen op het Nabije Oosten. De groeiende koloniale invloed van Engeland in Azië, met name in India, weerspiegelde zich echter ook in de kolommen van het tijdschrift. Een politiek gevoelig artikel maakte waarschijnlijk een einde aan het blad.

  19. La théorie de la diplomatie dans le Saint Empire Romain

    OpenAIRE

    Weber, Wolfgang E. J.

    2016-01-01

    Principes Dans ce que l’on nomme officiellement, depuis 1500 environ jusqu’à sa fin en 1806, le Saint Empire romain de la nation allemande (Heiliges Römisches Reich Deutscher Nation), le développement de la théorie de la diplomatie, autrement dit de conceptions relatives aux diplomates et à la diplomatie, est le fait d’élites soucieuses de mieux comprendre des problèmes posé...

  20. Implementation framework for chronic disease intervention effectiveness in Māori and other indigenous communities.

    Science.gov (United States)

    Oetzel, John; Scott, Nina; Hudson, Maui; Masters-Awatere, Bridgette; Rarere, Moana; Foote, Jeff; Beaton, Angela; Ehau, Terry

    2017-09-05

    About 40% of all health burden in New Zealand is due to cancer, cardiovascular disease, and type 2 diabetes/obesity. Outcomes for Māori (indigenous people) are significantly worse than non-Maori; these inequities mirror those found in indigenous communities elsewhere. Evidence-based interventions with established efficacy may not be effective in indigenous communities without addressing specific implementation challenges. We present an implementation framework for interventions to prevent and treat chronic conditions for Māori and other indigenous communities. The He Pikinga Waiora Implementation Framework has indigenous self-determination at its core and consists of four elements: cultural-centeredness, community engagement, systems thinking, and integrated knowledge translation. All elements have conceptual fit with Kaupapa Māori aspirations (i.e., indigenous knowledge creation, theorizing, and methodology) and all have demonstrated evidence of positive implementation outcomes. A coding scheme derived from the Framework was applied to 13 studies of diabetes prevention in indigenous communities in Australia, Canada, New Zealand, and the United States from a systematic review. Cross-tabulations demonstrated that culture-centeredness (p = .008) and community engagement (p = .009) explained differences in diabetes outcomes and community engagement (p = .098) explained difference in blood pressure outcomes. The He Pikinga Waiora Implementation Framework appears to be well suited to advance implementation science for indigenous communities in general and Māori in particular. The framework has promise as a policy and planning tool to evaluate and design effective interventions for chronic disease prevention in indigenous communities.

  1. Fabrication, characterization, and heuristic trade space exploration of magnetically actuated Miura-Ori origami structures

    Science.gov (United States)

    Cowan, Brett; von Lockette, Paris R.

    2017-04-01

    The authors develop magnetically actuated Miura-Ori structures through observation, experiment, and computation using an initially heuristic strategy followed by trade space visualization and optimization. The work is novel, especially within origami engineering, in that beyond final target shape approximation, Miura-Ori structures in this work are additionally evaluated for the shape approximation while folding and for their efficient use of their embedded actuators. The structures consisted of neodymium magnets placed on the panels of silicone elastomer substrates cast in the Miura-Ori folding pattern. Initially four configurations, arrangements of magnets on the panels, were selected based on heuristic arguments that (1) maximized the amount of magnetic torque applied to the creases and (2) reduced the number of magnets needed to affect all creases in the pattern. The results of experimental and computational performance metrics were used in a weighted sum model to predict the optimum configuration, which was then fabricated and experimentally characterized for comparison to the initial prototypes. As expected, optimization of magnet placement and orientation was effective at increasing the degree of theoretical useful work. Somewhat unexpectedly, however, trade space results showed that even after optimization, the configuration with the most number of magnets was least effective, per magnet, at directing its actuation to the structure’s creases. Overall, though the winning configuration experimentally outperformed its initial, non-optimal counterparts, results showed that the choice of optimum configuration was heavily dependent on the weighting factors. These results highlight both the ability of the Miura-Ori to be actuated with external magnetic stimuli, the effectiveness of a heuristic design approach that focuses on the actuation mechanism, and the need to address path-dependent metrics in assessing performance in origami folding structures.

  2. VizieR Online Data Catalog: sigma Ori low-mass stars (Kenyon+, 2005)

    Science.gov (United States)

    Kenyon, M. J.; Jeffries, R. D.; Naylor, T.; Oliveira, J. M.; Maxted, P. F. L.

    2005-04-01

    We observed the field around sigma Ori with the Wide Field Camera (WFC) on the 2.5-m Isaac Newton Telescope using Harris R and Sloan i filters on the nights of 1999 September 2730. Spectra were obtained with the Wide Field Fiber Optic Spectrograph (WYFFOS) mounted at the Nasmyth focus of the 4.2-m William Herschel Telescope during the nights of 1999 December 11 and 12. (5 data files).

  3. ORI findings of scientific misconduct in clinical trials and publicly funded research, 1992-2002.

    Science.gov (United States)

    Reynolds, Sandra M

    2004-01-01

    Since 1992 the Office of Research Integrity (ORI) had reviewed investigations of scientific misconduct in research funded by the US Public Health Service (PHS). ORI defined scientific misconduct as "fabrication, falsification, plagiarism, or other practices that seriously deviate from those that are commonly accepted within the scientific community for proposing, conducting, or reporting research". The purpose of this study was to summarize the findings and administrative actions reported in ORI notices of scientific misconduct in clinical trials occurring between May 1992 and 2002. Findings of misconduct were gathered from publicly available sources: the ORI annual reports and the NIH Guide to Grants and Contracts. Clinical trials accounted for 17 (13%) of the 136 investigations that resulted in findings of scientific misconduct, and they were noted in 12 (11%) of the 113 brief reports of investigations closed with findings of no scientific misconduct. In clinical trials, the most severe sanction, debarment from US Government funding, was applied in six (35%) of the cases of misconduct compared to 79 (66%) of 119 cases from all other types of research combined. Of individuals cited for misconduct in clinical trials, three (18%) held doctorates in contrast to 81 (68%) in other types of research. In clinical trials, junior employees may bear the burden of sanction for scientific misconduct. The most frequently applied sanction was the requirement that a plan of supervision of the sanctioned employees accompany any future application for funding which would include them. This imposition of sanction on an individual employee does not address possible causes of misconduct which may be inherent in the overall pattern of leadership, training and supervision in the trial. Furthermore, the definition of misconduct, as interpreted by the Departmental Appeals Board, excludes carelessness and other poor research practices that may lead to dissemination of more incorrect data

  4. Reducing smoking in pregnancy among Māori women: "aunties" perceptions and willingness to help.

    Science.gov (United States)

    van Esdonk, Tineke; Glover, Marewa; Kira, Anette; Wagemakers, Annemarie

    2014-12-01

    ori (the indigenous people of New Zealand) women have high rates of smoking during pregnancy and 42 % register with a lead maternity carer (LMC) after their first trimester, delaying receipt of cessation support. We used a participatory approach with Māori community health workers ("Aunties") to determine their willingness and perceived ability to find pregnant Māori smokers early in pregnancy and to provide cessation support. Three meetings were held in three different regions in New Zealand. The aunties believed they could find pregnant women in first trimester who were still smoking by using their networks, the 'kumara-vine' (sweet potato vine), tohu (signs/omens), their instinct and by looking for women in the age range most likely to get pregnant. The aunties were willing to provide cessation and other support but they said they would do it in a "Māori way" which depended on formed relationships and recognised roles within families. The aunties' believed that their own past experiences with pregnancy and/or smoking would be advantageous when providing support. Aunties' knowledge about existing proven cessation methods and services and knowledge about how to register with a LMC ranged from knowing very little to having years of experience working in the field. They were all supportive of receiving up-to-date information on how best to support pregnant women to stop smoking. Aunties in communities believe that they could find pregnant women who smoke and they are willing to help deliver cessation support. Our ongoing research will test the effectiveness of such an approach.

  5. Are capecitabine and the active metabolite 5-Fu CNS penetrable to treat breast cancer brain metastasis?

    Science.gov (United States)

    Zhang, Jinqiang; Zhang, Lingli; Yan, Yumei; Li, Shaorong; Xie, Liang; Zhong, Wei; Lv, Jing; Zhang, Xiuhua; Bai, Yu; Cheng, Ziqiang

    2015-03-01

    Brain metastasis (BM) is increasingly diagnosed in Her2 positive breast cancer (BC) patients. Lack of effective treatment to breast cancer brain metastases (BCBMs) is probably due to inability of the current therapeutic agents to cross the blood-brain barrier. The central nervous system (CNS) response rate in BCBM patients was reported to improve from 2.6%-6% (lapatinib) to 20%-65% (lapatinib in combination with capecitabine). Lapatinib is a poor brain penetrant. In this study, we evaluated the CNS penetration of capecitabine and hoped to interpret the mechanism of the improved CNS response from the pharmacokinetic (PK) perspective. Capecitabine does not have antiproliferative activity and 5-fluorouracil (5-FU) is the active metabolite. Capecitabine was orally administered to mouse returning an unbound brain-to-blood ratio (Kp,uu,brain) at 0.13 and cerebrospinal fluid (CSF)-to-unbound blood ratio (Kp,uu,CSF) at 0.29 for 5-FU. Neither free brain nor CSF concentration of 5-FU can achieve antiproliferative concentration for 50% of maximal inhibition of cell proliferation of 4.57 µM. BCBM mice were treated with capecitabine monotherapy or in combination with lapatinib. The Kp,uu,brain value of 5-FU increased to 0.17 in the brain tumor in the presence of lapatinib, which is still far below unity. The calculated free concentration of 5-FU and lapatinib in the brain tumor did not reach the antiproliferative potency and neither treatment showed antitumor activity in the BCBM mice. The CNS penetration of 5-FU in human was predicted based on the penetration in preclinical brain tumor, CSF, and human PK and the predicted free CNS concentration was below the antiproliferative potency. These results suggest that CNS penetration of 5-FU and lapatinib are not desirable and development of a true CNS penetrable therapeutic agent will further improve the response rate for BCBM.

  6. In vitro and in vivo antitumor effect of 5-FU combined with piplartine and piperine.

    Science.gov (United States)

    Bezerra, Daniel P; de Castro, Fernanda O; Alves, Ana Paula N N; Pessoa, Cláudia; de Moraes, Manoel Odorico; Silveira, Edilberto R; Lima, Mary Anne S; Elmiro, Francisca Juliana M; de Alencar, Nylane M N; Mesquita, Rodney O; Lima, Michael W; Costa-Lotufo, Letícia V

    2008-03-01

    It has been reported that piplartine and piperine, alkaloid/amide compounds from Piper species, show antitumor activities. In the present paper, the effects of the combination of 5-fluorouracil (5-FU) with piplartine or piperine was determined using in vitro and in vivo experimental models. Hematological and biochemical analyses, as well as histopathological and morphological analyses of the tumor and the organs, including liver, spleen and kidney, were performed in order to evaluate the toxicological aspects associated with different treatments. The incubation of tumor cell lines with 5-FU in the presence of piplartine or piperine produced an increase in growth inhibition, as observed by lower IC50 values for 5-FU. These effects were also observed in vivo, where the combination with piplartine but not piperine with 5-FU led to a higher tumor growth inhibition. The results indicated that either piplartine- or 5-FU-treated animals showed a low inhibition rate when they were used individually at low doses of 28.67% and 47.71%, respectively, but when they were combined at the same dose, the inhibition rate increased significantly to 68.04%. The histopathological analysis showed that the livers and the kidneys of treated animals were only slightly and reversibly affected. Neither the enzymatic activity of transaminases nor the urea levels were significantly modified when compared with the control group. Hematological analysis showed leukopenia after 5-FU treatment, which was reversed by the combined use of piplartine and piperine. These findings indicate that piplartine may enhance the therapeutic effectiveness of chemotherapeutic drugs, and moreover, this combination could improve immunocompetence hampered by 5-FU.

  7. Randomised phase III study of biweekly 24-h infusion of high-dose 5FU with folinic acid and oxaliplatin versus monthly plus 5-FU/folinic acid in first-line treatment of advanced colorectal cancer

    NARCIS (Netherlands)

    Hospers, GAP; Schaapveld, M; Nortier, JWR; Wils, J; van Bochove, A; de Jong, RS; Creemers, GJ; Erjavec, Z; de Gooyer, DJ; Slee, PHTJ; Gerrits, CJH; Smit, J.M.; Mulder, NH

    2006-01-01

    Background: A phase III study was started to compare oxaliplatin/5FU/LV in the first-line with bolus FU/LV in metastatic colorectal cancer. Patients and methods: 302 patients were randomised and received bolus 5-FU 425 mg/m(2) day 1-5, FA 20 mg/m(2) day 1-5, q 4 wk or oxaliplatin 85 mg/m(2), 2 h-inf

  8. Effect of Expiratory Resistive Loading in Expiratory Muscle Strength Training on Orbicularis Oris Muscle Activity

    Science.gov (United States)

    Yanagisawa, Yukio; Matsuo, Yoshimi; Shuntoh, Hisato; Horiuchi, Noriaki

    2014-01-01

    [Purpose] The purpose of this study was to elucidate the effect of expiratory resistive loading on orbicularis oris muscle activity. [Subjects] Subjects were 23 healthy individuals (11 males, mean age 25.5±4.3 years; 12 females, mean age 25.0±3.0 years). [Methods] Surface electromyography was performed to measure the activity of the orbicularis oris muscle during maximum lip closure and resistive loading at different expiratory pressures. Measurement was performed at 10%, 30%, 50%, and 100% of maximum expiratory pressure (MEP) for all subjects. The t-test was used to compare muscle activity between maximum lip closure and 100% MEP, and analysis of variance followed by multiple comparisons was used to compare the muscle activities observed at different expiratory pressures. [Results] No significant difference in muscle activity was observed between maximum lip closure and 100% MEP. Analysis of variance with multiple comparisons revealed significant differences among the different expiratory pressures. [Conclusion] Orbicularis oris muscle activity increased with increasing expiratory resistive loading. PMID:24648644

  9. X-ray Variability in the Young Massive Triple theta2 Ori A

    CERN Document Server

    Schulz, N S; Huenemoerder, D P; Ishibashi, K; Canizares, C R; Schulz, Norbert S.; Testa, Paola; Huenemoerder, David P.; Ishibashi, Kazunori; Canizares, Claude R.

    2006-01-01

    Massive stars rarely show intrinsic X-ray variability. The only O-stars credited to be intrinsically variable are theta1 Ori C due to effects from magnetic confinement of its wind, and theta2 Ori A suspected of similar activity. Early Chandra observations have shown that the most massive star system in the Orion Trapezium Cluster, theta2 Ori A, shows rapid variability on time scales of hours. We determine X-ray fluxes and find that the star shows very strong variability over the last 5 years. We observed a second large X-ray outburst in November 2004 with the high resolution transmission grating spectrometer on-board Chandra. In the low state X-ray emissivities indicate temperatures well above 25 MK. In the high state we find an extended emissivity distribution with high emissivities in the range from 3 MK to over 100 MK. The outburst event in stellar terms is one of the most powerful ever observed and the most energetic one in the ONC with a lower total energy limit of 1.5x10^37 ergs. The line diagnostics sh...

  10. The inner circumstellar disk of the UX Ori star V1026 Sco

    CERN Document Server

    Vural, J; Kishimoto, M; Weigelt, G; Hofmann, K -H; Kraus, S; Schertl, D; Dugué, M; Duvert, G; Lagarde, S; Massi, F

    2014-01-01

    The UX Ori type variables (named after the prototype of their class) are intermediate-mass pre-main sequence objects. One of the most likely causes of their variability is the obscuration of the central star by orbiting dust clouds. We investigate the structure of the circumstellar environment of the UX~Ori star V1026 Sco (HD 142666) and test whether the disk inclination is large enough to explain the UX Ori variability. We observed the object in the low-resolution mode of the near-infrared interferometric VLTI/AMBER instrument and derived H- and K-band visibilities and closure phases. We modeled our AMBER observations, published Keck Interferometer observations, archival MIDI/VLTI visibilities, and the spectral energy distribution using geometric and temperature-gradient models. Employing a geometric inclined-ring disk model, we find a ring radius of 0.15 +- 0.06 AU in the H band and 0.18 +- 0.06 AU in the K band. The best-fit temperature-gradient model consists of a star and two concentric, ring-shaped disk...

  11. Identification of oriT and a recombination hot spot in the IncA/C plasmid backbone.

    Science.gov (United States)

    Hegyi, Anna; Szabó, Mónika; Olasz, Ferenc; Kiss, János

    2017-09-06

    Dissemination of multiresistance has been accelerating among pathogenic bacteria in recent decades. The broad host-range conjugative plasmids of the IncA/C family are effective vehicles of resistance determinants in Gram-negative bacteria. Although more than 150 family members have been sequenced to date, their conjugation system and other functions encoded by the conserved plasmid backbone have been poorly characterized. The key cis-acting locus, the origin of transfer (oriT), has not yet been unambiguously identified. We present evidence that IncA/C plasmids have a single oriT locus immediately upstream of the mobI gene encoding an indispensable transfer factor. The fully active oriT spans ca. 150-bp AT-rich region overlapping the promoters of mobI and contains multiple inverted and direct repeats. Within this region, the core domain of oriT with reduced but detectable transfer activity was confined to a 70-bp segment containing two inverted repeats and one copy of a 14-bp direct repeat. In addition to oriT, a second locus consisting of a 14-bp imperfect inverted repeat was also identified, which mimicked the function of oriT but which was found to be a recombination site. Recombination between two identical copies of these sites is RecA-independent, requires a plasmid-encoded recombinase and resembles the functioning of dimer-resolution systems.

  12. Effect of resveratrol and in combination with 5-FU on murine liver cancer

    Institute of Scientific and Technical Information of China (English)

    Sheng-Li Wu; Zhong-Jie Sun; Liang Yu; Ke-Wei Meng; Xing-Lei Qin; Cheng-En Pan

    2004-01-01

    AIM: To study the anti-tumor effect of resveratrol and in combination with 5-FU on murine liver cancer.METHODS: Transplantable murine hepatoma22 model was used to evaluate the anti-tumor activity of resveratrol (RES)alone or in combination with 5-FU in vivo. H22 cell cycles were analyzed with flow cytometry.RESULTS: Resveratrol could inhibit the growth of murine hepatoma22, after the mice bearing H22 tumor were treated with 10 mg/kg or 15 mg/kg resveratrol for ten days, and the inhibition rates were 36.3% (n = 10) and 49.3% (n = 9),respectively, which increased obviously compared with that in control group (85±22 vs 68±17, P<0.01). RES could induce the S phase arrest of H22 cells, and increase the persentage of cells in S phase from 59.1% (n = 9) to 73.5% (n = 9) in a dose-dependent manner (P<0.05). The enhanced inhibition of tumor growth by 5-FU was also observed in hepatoma22 bearing mice when 5-FU was administered in combination with 10 mg/kg resveratrol. The inhibition rates for 20 mg/kg or 10 mg/kg 5-FU in combination with 10 mg/kg resveratrol were 77.4% and 72.4%, respectively, compared with the group of 20 mg/kg or 10 mg/kg 5-FU alone, in which the inhibition rates were 53.4% and 43.8%, respectively (n = 8). There was a statistical significance between the combination group and 5-FU group.CONCLUSION: RES could induce the S phase arrest of H22cells and enhance the anti-tumor effect of 5-FU on murine hepatoma22 and antagonize its toxicity markedly. These results suggest that resveratrol, as a biochemical modulator to enhance the therapeutic effects of 5-FU, may be potentially useful in cancer chemotherapy.

  13. A molecular outflow driven by the brown dwarf binary FU Tau

    CERN Document Server

    Monin, J -L; Lefloch, B; Dougados, C; de Oliveira, C Alves

    2013-01-01

    We report the detection of a molecular outflow driven by the brown dwarf binary FU Tau. Using the IRAM 30 m telescope we observed the $^{12}$CO(2-1) (CO) emission in the vicinity of FU Tau and detected a bipolar outflow by examining the wings of the CO(2-1) line as we moved away from the source position. An integrated map of the wing emission between 3 kms$^{-1}$ and 5 kms$^{-1}$ reveals a blue-shifted lobe at a position of $\\sim$ 20 \\arcsec\\ from the FU Tau system and at a position angle of $\\sim$ 20$^{\\circ}$. The beam size of the observations is $11\\arcsec$\\ hence it is not possible to distinguish between the two components of the FU Tau binary. However as optical forbidden emission, a strong tracer of the shocks caused by outflow activity, has been detected in the spectrum of FU Tau A we assume this component to be the driving source of the molecular outflow. We estimate the mass and mass outflow rate of the outflow at 4 $\\times$ 10$^{-6}$ \\Msun\\ and 6 $\\times$ 10$^{-10}$ \\Msun/yr respectively. These resu...

  14. Targeting distribution of PEG-5-FU-MAMS in colorectal carcinoma tissue of nude mice%PEG-5-FU-MAMS靶向治疗裸鼠大肠癌的实验研究

    Institute of Scientific and Technical Information of China (English)

    房玉海; 张春林; 洪志飞

    2014-01-01

    目的 研究聚乙二醇(polyethylene glycol,PEG)修饰的5-氟尿嘧啶磁性白蛋白微球(PEG-modified 5-FU magnetic albumin microsphere,PEG-5-FU-MAMS)和5-氟尿嘧啶磁性白蛋白微球(5-FU-MAMS)对大肠癌组织的被动靶向性,为实现大肠癌的主动靶向治疗,减少化疗药物的不良反应寻找新的途径.方法 30只人大肠癌裸鼠随机分为3组:(1)游离5-FU组;(2) 5-FU-MAMS组;(3) PEG-5-FU-MAMS组.每组10只,分别将3种不同的制剂(按5-FU 8mg/kg)经尾静脉给药,30分钟后,经眼眶采血,处死裸鼠,用HPLC法测定血清、肿瘤、肾脏、肝脏组织5-FU的浓度.结果 (1)PEG-5-FU-MAMS组、5-FU-MAMS组和游离5-FU组肿瘤组织中的药物浓度分别为(51.2±2.1) mg/L、(33.1 ±8.2)mg/L和(20.3±1.9) mg/L,PEG-5-FU-MAMS组肿瘤组织中药物浓度明显高于5-FU-MAMS和游离5-FU组(P<0.01);而在血清中药物浓度相反,PEG-5-FU-MAMS组[(1.7±0.5)mg/L]明显低于5-FU-MAMS[(6.8±0.2)mg/L]和游离5-FU组[(7.1±0.8)mg/L] (P <0.01);PEG-5-FU-MAMS组肝、肾脏中药物浓度[(22.7±2.4) mg/L和(21.1±2.3)mg/L]明显低于5-FU-MAMS[(44.3±6.7)mg/L和(38.2±4.9) mg/L]和游离5-FU组[(45.9 ±7.8)mg/L和(39.7±3.2)mg/L] (P <0.05).(2)PEG-5-FU-MAMS对裸鼠大肠癌的抑瘤率明显高于游离5-FU和5-FU-MAMS(45.3% vs 15.0%、30.1%,P<O.05).结论 PEG-5-FU-MAMS对大肠癌组织的靶向作用明显强于5-FU-MAMS和游离5-FU,但肝、肾脏的被动靶向作用明显减弱,有效地减轻药物对肝、肾脏的不良反应.PEG-5-FU-MAMS的抗结直肠癌作用明显强于游离5-FU和5-FU-MAMS.PEG-5-FU-MAMS有望成为肿瘤主动靶向治疗的有效药物.

  15. Overview of the Fusion Z-Pinch Experiment FuZE

    Science.gov (United States)

    Weber, T. R.; Shumlak, U.; Nelson, B. A.; Golingo, R. P.; Claveau, E. L.; McLean, H. S.; Tummel, K. K.; Higginson, D. P.; Schmidt, A. E.; UW/LLNL Team

    2016-10-01

    Previously, the ZaP device, at the University of Washington, demonstrated sheared flow stabilized (SFS) Z-pinch plasmas. Instabilities that have historically plagued Z-pinch plasma confinement were mitigated using sheared flows generated from a coaxial plasma gun of the Marshall type. Based on these results, a new SFS Z-pinch experiment, the Fusion Z-pinch Experiment (FuZE), has been constructed. FuZE is designed to investigate the scaling of SFS Z-pinch plasmas towards fusion conditions. The experiment will be supported by high fidelity physics modeling using kinetic and fluid simulations. Initial plans are in place for a pulsed fusion reactor following the results of FuZE. Notably, the design relies on proven commercial technologies, including a modest discharge current (1.5 MA) and voltage (40 kV), and liquid metal electrodes. Supported by DoE FES, NNSA, and ARPA-E ALPHA.

  16. Preparation and evaluation of chitosan based thermoreversible gels for intraperitoneal delivery of 5-fluorouracil (5-FU).

    Science.gov (United States)

    Depani, Bhavesh P; Naik, Anuja A; Nair, Hema A

    2013-12-01

    Sterile thermoreversibly gelling systems based on chitosan- glycerol phosphate were developed for intraperitoneal delivery of the antineoplastic agent 5-FU. The formulation was evaluated for gelling characteristics and in vitro drug release. Drug free gels were evaluated for in vitro cytotoxicity in L-929 mouse fibroblast cells. Drug loaded gels were subjected to acute toxicity studies in Swiss albino mice via intraperitoneal route and efficacy studies via intratumoral injections in subcutaneous colon carcinoma bearing BALB/c mice. The formulations gelled reversibly in 8 min at 37 °C and provided prolonged release of the drug. Drug free systems showed dose dependent cytotoxicity in fibroblast cells, while in vivo studies revealed a 2.8-fold increase in LD50 of 5-FU administered intraperitoneally as the developed system. Tumor volume measurements showed comparable efficacy of 5-FU administered as gel and commercial injection with a greatly improved safety profile of the former as adjudged from mortality and body weight measurements.

  17. Prospective randomized trial comparing mitomycin, cisplatin, and protracted venous-infusion fluorouracil (PVI 5-FU) With epirubicin, cisplatin, and PVI 5-FU in advanced esophagogastric cancer.

    Science.gov (United States)

    Ross, P; Nicolson, M; Cunningham, D; Valle, J; Seymour, M; Harper, P; Price, T; Anderson, H; Iveson, T; Hickish, T; Lofts, F; Norman, A

    2002-04-15

    We report the results of a prospectively randomized study that compared the combination of epirubicin, cisplatin, and protracted venous-infusion fluorouracil (PVI 5-FU) (ECF) with the combination of mitomycin, cisplatin, and PVI 5-FU (MCF) in previously untreated patients with advanced esophagogastric cancer. Five hundred eighty patients with adenocarcinoma, squamous carcinoma, or undifferentiated carcinoma were randomized to receive either ECF (epirubicin 50 mg/m(2) every 3 weeks, cisplatin 60 mg/m(2) every 3 weeks and PVI 5-FU 200 mg/m(2)/d) or MCF (mitomycin 7 mg/m(2) every 6 weeks, cisplatin 60 mg/m(2) every 3 weeks, and PVI 5-FU 300 mg/m(2)/d) and analyzed for survival, response, toxicity, and quality of life (QOL). The overall response rate was 42.4% (95% confidence interval [CI], 37% to 48%) with ECF and 44.1% (95% CI, 38% to 50%) with MCF (P =.692). Toxicity was tolerable, and there were only two toxic deaths. ECF resulted in more grade 3/4 neutropenia and grade 2 alopecia, but MCF caused more thrombocytopenia and plantar-palmar erythema. Median survival was 9.4 months with ECF and 8.7 months with MCF (P =.315); at 1 year, 40.2% (95% CI, 34% to 46%) of ECF and 32.7% (95% CI, 27% to 38%) of MCF patients were alive. Median failure-free survival was 7 months with both regimens. Global QOL scores were better with ECF at 3 and 6 months. This study confirms response, survival, and QOL benefits of ECF observed in a previous randomized study. The equivalent efficacy of MCF was demonstrated, but QOL was superior with ECF. ECF remains one of the reference treatments for advanced esophagogastric cancer.

  18. Reply to communications by Fu et al. international journal of biometeorology

    Science.gov (United States)

    Wang, Huanjiong; Rutishauser, This; Tao, Zexing; Zhong, Shuying; Ge, Quansheng; Dai, Junhu

    2016-12-01

    Temperature sensitivity of plant phenology (ST) is a determining factor of as to what degree climate change impacts on plant species. Fu et al . (Int J Biometeorol 60:1611-1613, 2016) claimed that long long-term linear trends mask phenological shifts. However, the decreased and increased ST was both found in warming scenarios. The conceptual scheme telling the nonlinear relationship between spring temperature and leaf unfolding date proposed by Fu et al . (Int J Biometeorol 60:1611-1613, 2016) cannot be supported by observation data across Europe. Therefore, linking declined ST to climate warming is misleading, and future ST changes are more uncertain than they suggested.

  19. Phenytoin toxicity due to fluoropyrimidines (5FU/capecitabine): three case reports.

    Science.gov (United States)

    Brickell, K; Porter, D; Thompson, P

    2003-08-18

    Interactions between phenytoin and the fluoropyrimidine derivatives, 5 fluorouracil (5FU) and capecitabine, are not commonly documented or widely recognised. As more people with significant medical comorbidities are now being considered for chemotherapy, it is increasingly likely that people receiving phenytoin will be prescribed treatment with fluoropyrimidines. We present two cases of clinical phenytoin toxicity occurring after starting treatment with 5-fluorouracil/folinic acid (5FU/FA) and a third who developed clinical phenytoin toxicity after starting capecitabine (an orally administered prodrug of fluorouracil).

  20. "Long term results of intraoperative 5-FU in Glaucoma filtering procedures "

    Directory of Open Access Journals (Sweden)

    "Hashemian MN

    2000-11-01

    Full Text Available This prospective study evaluated the long-term results of intraoperative 5-FU in glaucoma patients undergoing trabeculectomy. 14 patients categorized as high risk or medium risk underwent trabeculectomy with 5-FU and were followed for a mean period of 32 months. Patients were evaluated for visual acuity, cup-disc ratio and intraocular pressure (IOP; the number of medications was also taken into consideration. 78% (11 of patients achieved controlled IOP (< 21 mmHg with or without medication. There was statistically significant reduction of IOP and number of medications after the operation. There were no significant complications observed during the follow-up period.

  1. ShoFu Vintage比色板的数码摄影研究%The digital color-matching study of ShoFu Vintage shade

    Institute of Scientific and Technical Information of China (English)

    叶荣荣; 包向军; 王德芳

    2007-01-01

    目的 用数码摄影方法研究ShoFu Vintage(松风)比色板各比色片中1/3区域的亮度(L)值及R、G、B值的分布规律,以期提高临床修复体的比色准确率.方法 在5000K光源下用数码相机对ShoFu Vintage比色板的各比色片进行摄影,将拍摄结果输入计算机,运行Photoshop7.0软件,记录各比色片中1/3区域的亮度(L)和R、G、B值.结果 比色片的亮度(L)值及R、G、B值的分布与其A、B、C、D系列的分类有关.同系列比色片中随标号序数的增加,亮度(L)值及G、B值反而降低.R值分布表现为各系列中间序号的比色片较高.结论 数码摄影能够比较真实地再现ShoFu Vintage(松风)比色板的颜色,可作为临床修复体比色方法的补充.

  2. Théories de la connaissance en économie : théories rationnelles appliquées à l’économie et théorie intuitive selon Edgar Salin

    Directory of Open Access Journals (Sweden)

    Bertram Schefold

    2007-05-01

    Full Text Available Il n’est pas toujours évident de rappeler aujourd’hui que l’économie politique contemporaine est née d’une fusion, et non seulement d’évictions successives, entre le formalisme moderne, des conceptions non formalisées – et peut-être dûment impossibles à formaliser – mais rationnelles, et des intuitions dont le statut philosophique a été – et demeure – l’une des grandes questions traitées en théorie de la connaissance, telle que l’a en particulier illustrée la tradition allemande depuis Kant jusqu’à nous. Une des tentatives majeures pour donner un statut à l’Anschauung dans la théorie économique a été conduite en Allemagne, puis en Suisse, par Edgar Salin (1892-1974 dont l’œuvre, fut inspirée par l’atmosphère régnant dans le cercle réuni autour du poète Stefan George dans l’Entre-deux guerres. Elle se présenta comme une conception alternative à celles de Popper et de Weber, tant quant à l’usage possible de l’intuition en regard du cadre de la rationalité scientifique qu’eu égard à l’architectonique et aux visées de l’économie politique. La présente étude restitue, d’une part, une brève généalogie du concept philosophique d’intuition et, d’autre part, constitue un des rares exposés en français de la doctrine développée par Salin, une pensée que le travail mené par les auteurs les a conduits à revaloriser dans l’optique d’épistémologie comparative qu’ils ont ici adoptée.

  3. Revealing the inclined circumstellar disk in the UX Ori system KK Ophiuchi

    Science.gov (United States)

    Kreplin, A.; Weigelt, G.; Kraus, S.; Grinin, V.; Hofmann, K.-H.; Kishimoto, M.; Schertl, D.; Tambovtseva, L.; Clausse, J.-M.; Massi, F.; Perraut, K.; Stee, Ph.

    2013-07-01

    We study the inner sub-AU region of the circumstellar environment of the UX Ori type star KK Oph with near-infrared VLTI/AMBER interferometry. We are particularly interested in the inclination of the star-disk system, and we will use this information to test the current standard picture for UX Ori stars. We recorded spectrally dispersed (R˜35) interferograms in the near-infrared H and K bands with the VLTI/AMBER instrument. The derived visibilities, closure phases and the SED of KK Oph were compared with two-dimensional geometric and radiative transfer models (RADMC). We obtained visibilities at four different position angles. Using two-dimensional geometric models, we derive an axis ratio ˜3.0 corresponding to an inclination of ˜70 degree. A fitted inclined ring model leads to a ring radius of 2.8 ± 0.2 mas, corresponding to 0.44 ± 0.03 AU at a distance of 160 pc, which is larger than the dust sublimation radius of ˜0.1 AU predicted for a dust sublimation temperature of 1500 K. Our derived two-dimensional RADMC model consists of a circumstellar disk with an inclination angle of ˜70 degree and an additional dust envelope. The finding of an ˜70 degree inclined disk around KK Oph is consistent with the prediction that UX Ori objects are seen under large inclination angles, and orbiting clouds in the line of sight cause the observed variability. Furthermore, our results suggest that the orbit of the companion KK Oph B and the disk plane are coplanar.

  4. Une théorie pour penser les industries culturelles et informationnelles ?

    Directory of Open Access Journals (Sweden)

    Pierre Mœglin

    2012-09-01

    Full Text Available Cet article traite de la naissance et du développement de la théorie des industries culturelles et informationnelles. Il procède des deux questions suivantes : pourquoi une théorie unifiée, plutôt que la juxtaposition de toutes les théorisations ayant accompagné les étapes successives de l’histoire de ces industries et le développement de chacun de leurs secteurs ? Pourquoi une théorie originale, au lieu des approches industrielles proposées, par exemple, par l’économie ou la sociologie ? À ces questions la réponse est, d’une part, que la diversité des appréciations sur les enjeux des industries culturelles et informationnelles et leurs contradictions, d’un auteur à l’auteur, illustre la dimension dialectique du développement des industries culturelles et informationnelles elles-mêmes. D’autre part, la singularité de ces industries justifie le recours à un modèle d’analyse différent du modèle industriel standard.This paper deals with the birth and development of the cultural and informational industries theory. It arises from two questions. First, why one unified theory, rather than juxtaposing the different attempts to understand these industries step by step and sector by sector ? Second, why a specific theory, instead of borrowing from economy or sociology, for instance ? The answer is on the one hand that the contradictions among researchers about the issues of the cultural and informational industries demonstrate in themselves the dialectical nature of their development ; on the other hand, that the specificity of these industries requires an analysis model quite different from the standard model.

  5. Herschel Observations of a Newly Discovered UX Ori Star in the Large Magellanic Cloud

    Science.gov (United States)

    Clayton, Geoffrey

    2010-10-01

    The LMC star, SSTISAGE1C J050756.44--703453.9, was first noticed during a survey of EROS-2 lightcurves for stars with large irregular brightness variations typical of the R Coronae Borealis (RCB) class. However, the visible spectrum showing emission lines including the Balmer and Paschen series as well as many Fe II lines is emphatically not that of an RCB star. This star has all of the characteristics of a typical UX Ori star. It has a spectral type of approximately A2 and has excited an H II region in its vicinity. However, if it is an LMC member, then it is very luminous for a Herbig Ae/Be star. It shows irregular drops in brightness of up to 2 mag, and displays the reddening and ``blueing'' typical of this class of stars. Its spectrum, showing a combination of emission and absorption lines, is typical of a UX Ori star that is in a decline caused by obscuration from the circumstellar dust. SSTISAGE1C J050756.44--703453.9 has a strong IR excess and significant emission is present out to 500 . Monte Carlo radiative transfer modeling of the SED requires that SSTISAGE1C J050756.44--703453.9 has both a dusty disk as well as a large extended diffuse envelope to fit both the mid- and far-IR dust emission. This star is a new member of the UX Ori subclass of the Herbig Ae/Be stars and only the second such star to be discovered in the LMC.

  6. Isolation of potential probiotic Lactobacillus oris HMI68 from mother's milk with cholesterol-reducing property.

    Science.gov (United States)

    Anandharaj, Marimuthu; Sivasankari, Balayogan

    2014-08-01

    The objective of this study was to evaluate the probiotic properties of Lactobacillus strains isolated from mother's milk and their effects on cholesterol assimilation. In this study 120 isolates from mother's milk were phenotypically and genotypically characterized. Among these, only 6 predominant strains were identified as Lactobacillus spp. The following parameters were selected as important test variables in model stomach passage survival trials: acid and bile tolerance, antimicrobial activity, antibiotic susceptibility and cholesterol reduction. Results showed that the considerable variation existed among six strains. Moreover, the strain HMI68 is the most acid-tolerant and the HMI28 and HMI74 is the most acid-sensitive of all strains tested. HMI118 did not grow at 0.5% and 1% bile concentration after 5 h but the HMI68 and HMI43 showed some tolerance to such bile concentration. The differences found in the growth rate were not significant (P > 0.05). HMI68 showed resistance to most of the antibiotics as well as antagonistic activity against the tested pathogens. The amount of cholesterol reduction is increased when the media supplemented with bile salts. HMI68 assimilate 61.05 ± 0.05 μg/ml cholesterol with the presence of 0.3% bile salt this could be significantly decreased by 25.41 ± 1.09 μg/ml without bile salt. HMI68 was identified to be Lactobacillus oris HMI68 and 16S rRNA sequence was deposited in the National Center for Biotechnological Information (GenBank). For the first time the cholesterol-reducing property of L. oris isolated from mother's milk were investigated in this study. Therefore the effective L. oris HMI68 strain was regarded as a candidate probiotic.

  7. Ancient DNA recovers the origins of Māori feather cloaks.

    Science.gov (United States)

    Hartnup, K; Huynen, L; Te Kanawa, R; Shepherd, L D; Millar, C D; Lambert, D M

    2011-10-01

    Feather cloaks ("kakahu"), particularly those adorned with kiwi feathers, are treasured items or "taonga" to the Māori people of "Aotearoa"/New Zealand. They are considered iconic expression of Māori culture. Despite their status, much of our knowledge of the materials used to construct cloaks, the provenance of cloaks, and the origins of cloak making itself, has been lost. We used ancient DNA methods to recover mitochondrial DNA sequences from 849 feather samples taken from 109 cloaks. We show that almost all (>99%) of the cloaks were constructed using feathers from North Island brown kiwi. Molecular sexing of nuclear DNA recovered from 92 feather cloak samples also revealed that the sex ratio of birds deviated from a ratio of 1:1 observed in reference populations. Additionally, we constructed a database of 185 mitochondrial control region DNA sequences of kiwi feathers comprising samples collected from 26 North Island locations together with data available from the literature. Genetic subdivision (G(ST)), nucleotide subdivision (N(ST)) and Spatial Analysis of Molecular Variants (SAMOVA) analyses revealed high levels of genetic structuring in North Island brown kiwi. Together with sequence data from previously studied ancient and modern kiwi samples, we were able to determine the geographic provenance of 847 cloak feathers from 108 cloaks. A surprising proportion (15%) of cloaks were found to contain feathers from different geographic locations, providing evidence of kiwi trading among Māori tribes or organized hunting trips into other tribal areas. Our data also suggest that the east of the North Island of New Zealand was the most prolific of all kiwi cloak making areas, with over 50% of all cloaks analyzed originating from this region. Similar molecular approaches have the potential to discover a wealth of lost information from artifacts of endemic cultures worldwide.

  8. Relationship between pharmacokinetics of 5-FU in plasma and in saliva, and toxicity of 5-fluorouracil/folinic acid

    NARCIS (Netherlands)

    Jansman, FGA; Coenen, JLLM; De Graaf, JC; Tobi, H; Sleijfer, DT; Brouwers, JRBJ

    2002-01-01

    Background: Dose adaptation based on pharmacokinetic parameters has been shown to decrease toxicity of some 5-fluorouracil(5-FU)-based continuous infusion regimens. Patients and Methods: In the present study the relationship between 5-FU pharmacokinetics in plasma and in saliva, and toxicity was inv

  9. Evaluation of 5-FU pharmacokinetics in cancer patients with DPD deficiency using a Bayesian limited sampling strategy

    NARCIS (Netherlands)

    Van Kuilenburg, A.; Hausler, P.; Schalhorn, A.; Tanck, M.; Proost, J.H.; Terborg, C.; Behnke, D.; Schwabe, W.; Jabschinsky, K.; Maring, J.G.

    2011-01-01

    Aims: Dihydropyrimidine dehydrogenase (DPD) is the initial enzyme in the catabolism of 5-fluorouracil (5FU) and DPD deficiency is an important pharmacogenetic syndrome. The main purpose of this study was to develop a limited sampling strategy to evaluate the pharmacokinetics of 5FU and to detect dec

  10. Attenuated Cardiac Mitochondrial-Dependent Apoptotic Effects by Li-Fu Formula in Hamsters Fed with a Hypercholesterol Diet

    Directory of Open Access Journals (Sweden)

    Wei-Wen Kuo

    2011-01-01

    Full Text Available Apoptosis involves in the pathogenesis of various cardiac abnormalities. This study intends to evaluate the effects of Li-Fu formula on cardiac apoptosis induced by hyper-cholesterol diet. Twenty-four male Golden Syrian hamsters were randomly divided into Control, Cholesterol and Li-Fu formula groups. Histopathological analysis, western blotting and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL assays were performed to measure the effects of Li-Fu formula on left ventricle. Significantly reduced TUNEL-positive cells and mitochondria- dependent apoptosis were observed in the left ventricle of hamsters from Li-Fu formula group compared to the Cholesterol group. Additionally, induced cardiac insulin like growth factor I receptor (IGFIR-dependent survival pathway was detected in the Li-Fu formula group compared to the Cholesterol group. Besides, minor fibrosis, increased collagen deposition, and myofibril disarray was detected in the Cholesterol group, whereas the reductions of collagen deposition and myofibril disarray were observed in the Li-Fu formula group. This study demonstrated that Li-Fu formula not only reduced the mitochondria-dependent apoptosis and fibrosis, but also enhanced the IGF-I survival pathway in the left ventricle from high cholesterol-fed hamsters. We suggest the protective effects of Li-Fu formula on cardiac apoptosis and therapeutic potentials against cardiovascular disease.

  11. La théorie des industries culturelles (et informationnelles, composante des SIC

    Directory of Open Access Journals (Sweden)

    Bernard Miège

    2012-09-01

    Full Text Available Inaugurer le Cahier central de la Revue des SIC est certes une forme de reconnaissance, mais cela comporte des obligations, au premier rang desquelles la nécessité d’intéresser des lecteurs a priori pas immédiatement concernés par la thématique.Si la théorie des industries culturelles est devenue progressivement une approche marquante des SIC, en France, en Europe et plus largement encore (avec des dénominations variables et des modalités spécifiques, ce n’est en effet ni en le proclamant ha...

  12. The mysterious Of?p class and the magnetic O-star Theta Ori C

    CERN Document Server

    Naze, Yael; Martins, Fabrice

    2008-01-01

    In recent years, the stars of the Of?p category have revealed a wealth of peculiar phenomena: varying line profiles, photometric changes, and X-ray overluminosity are only a few of their characteristics. Here we review their physical properties, to facilitate comparisons among the Galactic members of this class. As one of them has been proposed to resemble the magnetic oblique rotator Theta Ori C, though with a longer period, this latter object is also included in our study to illuminate its similarities and differences with the Of?p category.

  13. La médiation. Théorie et terrains

    OpenAIRE

    2016-01-01

    Cette publication collective sur la notion de médiation est issue du constat suivant : dans le champ théorique comme dans le champ des pratiques, la médiation s’est aujourd’hui imposée, soit comme outil d’analyse des processus de communication, soit comme outil apte à soigner/traiter/améliorer les relations entre pairs, ou entre individus et institutions. Or la médiation reste un concept « instable », aussi bien dans la théorie, où elle est investie de toutes parts, que dans les pratiques, où...

  14. L'étranger de la théorie chez P. Fédida: la théorie de la supervision et le Centre d'Estudes du Vivant

    Directory of Open Access Journals (Sweden)

    François Villa

    2007-09-01

    Full Text Available L'auteur montre qu 'il y a, chez P. Fédida, une continuité de démarche entre sa théorie de la psychanalyse de supervision et la théorie sur laquelle repose le projet du Centre d'Etudes du Vivant. Tant dans la supervision que dans la controverse entre la psychanalyse et d'autres disciplines, ce qui est en jeu c'est l'étranger de la théorie. Celui-ci défait l'illusion des supposées bases communes de la psychanalyse. C'est à partir de cet interlocuteur " interne" à chaque discipline que peut s'organiser une controverse sur les objets qui sont à la frontière des diverses sciences du vivant.

  15. The prevalence of symptoms of depression and anxiety, and the level of life stress and worry in New Zealand Māori and non-Māori women in late pregnancy.

    Science.gov (United States)

    Signal, T Leigh; Paine, Sarah-Jane; Sweeney, Bronwyn; Muller, Diane; Priston, Monique; Lee, Kathryn; Gander, Philippa; Huthwaite, Mark

    2017-02-01

    To describe the prevalence of symptoms of depression and anxiety, and the level of life stress and worry in late pregnancy for Māori and non-Māori women. In late pregnancy, women completed a questionnaire recording their prior history of mood disorders; self-reported current depressive symptoms (⩾13 on the Edinburgh Postnatal Depression Scale), current anxiety symptoms (⩾6 on the anxiety items from the Edinburgh Postnatal Depression Scale), significant life stress (⩾2 items on life stress scale) and dysfunctional worry (>12 on the Brief Measure of Worry Scale). Data were obtained from 406 Māori women (mean age = 27.6 years, standard deviation=6.3 years) and 738 non-Māori women (mean age = 31.6 years, standard deviation=5.3 years). Depressive symptoms (22% vs 15%), anxiety symptoms (25% vs 20%), significant life stress (55% vs 30%) and a period of poor mood during the current pregnancy (18% vs 14%) were more prevalent for Māori than non-Maori women. Less than 50% of women who had experienced ⩾2 weeks of poor mood during the current pregnancy had sought help. Being young was an independent risk factor for depressive symptoms, significant life stress and dysfunctional worry. A prior history of depression was also consistently associated with a greater risk of negative affect in pregnancy. Antenatal mental health requires at least as much attention and resourcing as mental health in the postpartum period. Services need to specifically target Māori women, young women and women with a prior history of depression.

  16. Civic Work, Civic Lessons: Intergenerational Reflections--An Interview with Thomas Ehrlich and Ernestine Fu

    Science.gov (United States)

    McTighe Musil, Caryn

    2014-01-01

    In a September 2013 interview, Thomas Ehrlich and Ernestine Fu--whose passion for public service is manifested in differing ways and from two dramatically different generational standpoints--discussed insights from their co-authored book, "Civic Work, Civic Lessons: Two Generations Reflect on Public Service (2013)." Septuagenarian Tom…

  17. 中国浮针疗法%CHINESE FU'S SUBCUTANEOUS NEEDLING

    Institute of Scientific and Technical Information of China (English)

    谭源生

    2007-01-01

    @@ Fu's Subcutaneous Needling is a kind of spreading needling in the subcutaneous shallow fascia around the limitative pain region[1,2]. Such therapy was invented in 1996. It is a kind of modern development on the basis of the traditional acupuncture, characterized as simple operation, safety, rapid therapeutic effect and broad indications.

  18. Unfälle mit Fußgängern

    Science.gov (United States)

    Burg, Heinz

    Auf einer gut ausgebauten Straße im innerörtlichen Bereich wurde eine Fußgängerin von einem Pkw erfasst. Die Fußgängerin kam für den Pkw von links. Nach Aussage einer Zeugin lief sie hinter einem Brückenpfeiler hervor auf die Fahrbahn, vermutlich um einen Bus zu erreichen. Die Kollisionsstelle war am Pkw vorne rechts, in der Frontscheibe rechts unten war eine Beschädigung, die wegen Haaranhaftung einem Kopfaufprall zugeordnet werden konnte. Vom Pkw waren Bremsspuren entstanden. Die Endlage der Fußgängerin und die Endlagen von Gegenständen konnten markiert und vermessen werden. Von der Polizei war ein Sachverständiger an die Unfallstelle gerufen worden. Er fand den Pkw in Endstellung und die auf der Fahrbahn liegenden Teile vor. Die Fußgängerin war bereits abtransportiert worden, der Pkw-Fahrer ebenfalls (Schock). Der Pkw-Fahrer hatte seinen Wagen abgesperrt.

  19. FuGeF: A Resource Bound Secure Forwarding Protocol for Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Idris Abubakar Umar

    2016-06-01

    Full Text Available Resource bound security solutions have facilitated the mitigation of spatio-temporal attacks by altering protocol semantics to provide minimal security while maintaining an acceptable level of performance. The Dynamic Window Secured Implicit Geographic Forwarding (DWSIGF routing protocol for Wireless Sensor Network (WSN has been proposed to achieve a minimal selection of malicious nodes by introducing a dynamic collection window period to the protocol’s semantics. However, its selection scheme suffers substantial packet losses due to the utilization of a single distance based parameter for node selection. In this paper, we propose a Fuzzy-based Geographic Forwarding protocol (FuGeF to minimize packet loss, while maintaining performance. The FuGeF utilizes a new form of dynamism and introduces three selection parameters: remaining energy, connectivity cost, and progressive distance, as well as a Fuzzy Logic System (FLS for node selection. These introduced mechanisms ensure the appropriate selection of a non-malicious node. Extensive simulation experiments have been conducted to evaluate the performance of the proposed FuGeF protocol as compared to DWSIGF variants. The simulation results show that the proposed FuGeF outperforms the two DWSIGF variants (DWSIGF-P and DWSIGF-R in terms of packet delivery.

  20. The voyage to McDonalds--short and long-term factors in the etiology of obesity in Mäori children in Aotearoa.

    Science.gov (United States)

    Gray, George

    2003-09-01

    In Aotearoa, it has been revealed that 14.7% of European adults are obese, compared with 27.5% for Mäori adults. It has been difficult to elucidate the recent trends in children and adolescents without large-scale population analysis, but a recent study of obesity in Auckland schoolchildren revealed a prevalence rate of 15.8% for Mäori children, compared with 8.6% for European children. This essay will review factors affecting the etiology of obesity in Mäori children. The classification of obesity will be examined before a discussion of short-term and long-term factors leading to obesity in this ethnic group. Measuring Obesity in Children It has been recommended that the BMI range for overweight in Mäori be increased to 27-32, and obesity a BMI greater than 32. Unfortunately though, there is no consensus among researchers and some studies may use the conventional obesity range of a BMI greater than 30 for both Mäori and non-Mäori children. Mäori disproportionately occupy low socioeconomic strata in Aotearoa. The significant discrepancy between obesity prevalence rates for Mäori and European children indicates that other factors are involved. Dietary fat intake, and by extension obesity, tend to be more prevalent for people in low socioeconomic groups, as numerous studies have shown. Therefore, the Mäori-European obesity discrepancy can be further explained by the discrepancy in socioeconomic status between these two groups, as national census data reveal that Mäori are disproportionately represented in all negative socioeconomic indices. However, for completeness, it is necessary to understand exactly why Mäori dominate these indices.

  1. Photometric Identification of the low-Mass Population of Orion OB1b I: The sigma Ori Cluster

    CERN Document Server

    Sherry, W H; Wolk, S J

    2004-01-01

    We report an optical photometric survey of 0.89 sq. degrees of the Orion OB1b association centered on sigma Ori. This region includes most of the sigma Ori cluster, the highest density region within Orion OB1b. We have developed a statistical procedure to identify the young, low-mass pre-main sequence population of the association. We estimate that the cluster has ~160 members in the mass range (0.2Ori appear to be a well matched pair of clusters, except for the ~2 Myr difference in their ages.

  2. Couples Work in Cultural Context: Te Ao Māori and Poststucturalist Practices Informing Counselor Training in Aotearoa New Zealand.

    Science.gov (United States)

    Connor, Helene; Gremillion, Helen; Meima, Yolanda

    2016-06-01

    This article outlines key themes that appear in the teaching of poststructuralist ideas and practices for couples counseling within the Postgraduate Diploma in Counseling Program at Unitec Institute of Technology in Auckland, New Zealand, and it explores the congruence of this pedagogical approach with Māori (indigenous) understandings of relationality, collaboration, and partnership. The diploma program's curriculum includes narrative therapy and relational language-making. Themes explored in this article include: understanding (heterosexual) couple relationships as contextualized entities, deconstructing dominant discourses of coupledom, and the positioning of counselors/teachers as nonexpert. Taking each theme in turn, the authors, one of them Māori and two Pākehā (European), articulate points of alignment with Māori cultural concepts and practices. © 2016 Family Process Institute.

  3. Redesigning the architecture of policy-making: Engaging with Māori on nanotechnology in New Zealand.

    Science.gov (United States)

    Munshi, Debashish; Kurian, Priya A; Morrison, Talei; Morrison, Sandra L

    2016-04-01

    Although there is an extensive literature on public engagement on the use of new and emerging technologies such as nanotechnology, there is little evidence of the participation of marginalised indigenous communities in processes of such engagement. How do particular cultural values and worldviews shape the perceptions of new technologies among such indigenous peoples? This article addresses this question through an analysis of the deliberations of an indigenous Māori citizens' panel on nanotechnology in Aotearoa New Zealand. An active process of public engagement with the nation's Māori stakeholders, and their conversations with nanotechnology experts, sustainability activists and Māori researchers, helps map an alternative, culture-based architecture of public engagement on policies around new technologies. The analysis is grounded in a concept of active citizenship that we term 'sustainable citizenship'.

  4. Benefitting from differences in knowledge, practice and belief: Māori oral traditions and natural hazards science

    Directory of Open Access Journals (Sweden)

    D. N. King

    2010-09-01

    Full Text Available This paper builds upon earlier work that argued the information and experience contained within the knowledge-practice-belief complex of Mātauranga Māori [Māori knowledge] is a valuable and neglected area of information and understanding about past catastrophic events in Aotearoa/New Zealand (A/NZ. Here we map Māori oral traditions (pūrākau that relate experience with extreme environmental disturbance (in particular, tsunamis around the A/NZ coast, compare the findings with geo-archaeological evidence, and discuss the scientific benefits to be gained by considering pūrākau as legitimate perspectives on history. Not surprisingly, there are both differences and complementarities between traditional Māori narratives and the available geo-archaeological evidence on extreme coastal disturbances. The findings presented here raise new and important questions about accepted geographies of tsunami risk, the causes and sources of their generation, as well as reasons for the relative paucity and abundance of information in some regions. Ways in which Mātauranga Taiao [Māori environmental knowledge] and contemporary science can be combined to produce new narratives about extreme environmental disturbance along the A/NZ coastline will require not only acceptance of other ways of knowing but also open engagement with Māori that respects their rights to tell their own histories. These efforts are encouraged to revitalise and ground-truth the interpretation of traditional stories, corroborate and/or question previous scientific deductions, and improve our collective understanding of the recurring impact of tectonic, geologic and meteorological-based events across A/NZ.

  5. La conception des environnements d’apprentissage : de la théorie à la pratique / de la pratique à la théorie La conception des environnements d’apprentissage : de la théorie à la pratique / de la pratique à la théorie

    Directory of Open Access Journals (Sweden)

    Jean-Jacques Quintin

    2000-06-01

    Full Text Available Cet article présente une approche en matière de conception d’environnements d’apprentissage multimédia qualifiée d’incrémentielle et d’itérative en ce sens qu’elle repose sur un affinage progressif du produit dans le cadre d’un partenariat étroit entre concepteur et client. L’approche proposée implique notamment la mise au point de prototypes qui feront l’objet de validations systématiques afin d’assurer l’adéquation avec les exigences et les contraintes du milieu d’accueil. S’appuyant sur une double posture de chercheur et de concepteur, l’approche se nourrit de la théorie en s’appuyant sur des modèles mais elle nourrit également la théorie à travers l’effort de modélisation qui l’accompagne.This paper describes a method of developing multimedia learning environments based on a close collaboration between the client and the team of developers. This approach uses different tools ans techniques (prototype, storyboard, concept maps... to progressively elaborate a product adequate to the client requirements and to ensure sufficient quality. Taking advantage of our specific situation of researchers and designers, the method is based on a coming and going between the pedagogical model and the development of a practical learning environment.

  6. The Radio Jet Associated with the Multiple V380 Ori System

    CERN Document Server

    Rodriguez, L F; Carrasco-Gonzalez, C; Anglada, G; Trejo, A

    2016-01-01

    The giant Herbig-Haro object 222 extends over $\\sim$6$'$ in the plane of the sky, with a bow shock morphology. The identification of its exciting source has remained uncertain over the years. A non-thermal radio source located at the core of the shock structure was proposed to be the exciting source. However, Very Large Array studies showed that the radio source has a clear morphology of radio galaxy and a lack of flux variations or proper motions, favoring an extragalactic origin. Recently, an optical-IR study proposed that this giant HH object is driven by the multiple stellar system V380 Ori, located about 23$'$ to the SE of HH 222. The exciting sources of HH systems are usually detected as weak free-free emitters at centimeter wavelengths. Here we report the detection of an elongated radio source associated with the Herbig Be star or with its close infrared companion in the multiple V380 Ori system. This radio source has the characteristics of a thermal radio jet and is aligned with the direction of the g...

  7. Optique de Fourier Théorie métaxiale et fractionnaire

    CERN Document Server

    Pellat-Finet, Pierre

    2009-01-01

    Fondée sur la théorie métaxiale de G. Bonnet et sur l’emploi de la transformation de Fourier fractionnaire, la présentation de l'optique de Fourier adoptée dans cet ouvrage est originale et renouvelle en grande partie le sujet. Outre les thèmes traités habituellement dans ce domaine – diffraction scalaire, formation des images, transfert de la cohérence, holographie, filtrage et corrélation optiques –, le livre inclut une théorie fractionnaire des résonateurs optiques et des faisceaux gaussiens, ou développe encore l’analogie entre diffraction et dispersion de groupe dans les fibres optiques, élargissant de la sorte le champ de la discipline. Issu de l’enseignement dispensé par l’auteur à l’Université et en écoles d’ingénieurs, étayé par ses propres recherches, le livre s’adresse autant à des étudiants en mastère de physique ou des élèves-ingénieurs qu’à des chercheurs ou ingénieurs souhaitant s’initier à l’optique de Fourier fractionnaire. Pierre Pellat-Fi...

  8. Oncoprotein expression of E6 and E7 does not prevent 5-fluorouracil (5FU) mediated G1/S arrest and apoptosis in 5FU resistant carcinoma cell lines.

    Science.gov (United States)

    Didelot, C; Mirjolet, J-F; Barberi-Heyob, M; Ramacci, C; Teiten, M-H; Merlin, J L

    2003-07-01

    5-Fluorouracil (5FU) exposure can lead to both G1/S arrest and apoptosis induction which are dependent of P53 induction. The human papilloma virus oncoproteins (HPV), E6 and E7, inactivate respectively P53 and Rb. P53 degradation by E6 protein, leads to lack of G1/S arrest after genotoxic stress. Overexpression of E7 protein prevents P53-induced G1/S arrest following DNA damage. However, few studies have described 5FU effect and efficacy on cancer cell lines presenting HPV 18 positive status. KB cell line and KB3 subline presented wild-type P53 status and difference in 5FU sensitivity. During 5FU exposure, P53 gene and protein expression was increased in both cell lines. E6 and E7 mRNA and protein expression was decreased in KB and KB3. P53 and E6 protein expressions were inversely correlated. 5FU exposure, induced a G1/S arrest which can be maintained or intensified by P53 via P21 induction expression. 5FU exposure has led to apoptosis induction related to P53 induction. In the present study, 5FU exposure was shown to induce G1/S arrest and apoptosis by P53-dependent molecular pathway, in HPV 18 positive cells.

  9. Otariodibacter oris and Bisgaardia genomospecies 1 isolated from infections in pinnipeds

    DEFF Research Database (Denmark)

    Hansen, Mie Johanne; Bertelsen, Mads Frost; Delaney, Martha Ann;

    2013-01-01

    in pure culture from four abscesses, an affected lymph node, and a bone lesion consistent with osteomyelitis. Otariodibacter oris was also cultured with Arcanobacterium phocae and β-hemolytic streptococci. A pure culture of Bisgaardia genomospecies 1 was obtained from an abscess in a harbor seal....... This is the first time, to our knowledge, that O. oris has been associated with infection. Isolation of these bacteria in pure culture from abscesses and osteomyelitis strongly indicates a pathogenic potential of this organism. Likewise, the isolation of Bisgaardia genomospecies 1 in pure culture from an abscess...

  10. An indigenous approach to explore health-related experiences among Māori parents: the Pukapuka Hauora asthma study

    Science.gov (United States)

    2013-01-01

    Background The prevalence of asthma for Indigenous New Zealand Māori is amongst the highest in the world. Recent evidence shows ethnic differences in asthma symptom prevalence in New Zealand have widened, with asthma symptoms and hospitalisation rates consistently higher for Māori across all age-groups, especially children and adolescents. This paper: outlines our qualitative, longitudinal research exploring the practical issues Māori children and their families face trying to achieve optimum asthma outcomes; details the research methods used within this study; and discusses the process evaluation findings of the features that made this approach successful in engaging and retaining participants in the study. Methods Thirty-two Māori families were recruited using a Kaupapa Māori (Māori way) Research approach. Each participated in a series of four in-depth interviews that were carried out at seasonal intervals over the course of one year. Families also took part in an interviewer-administered questionnaire and participated in a Photovoice exercise. All interviews were digitally recorded, transcribed verbatim and independently coded by two researchers. The research team then conducted the analysis and theme development. The questionnaires were analysed separately, with explanations for findings explored within the qualitative data. Results The methodology produced a 100 percent retention rate of the participating families over the course of the follow-up. This was attributed to the research collaboration, the respectful research relationships established with families, and the families’ judgement that the methods used enabled them to tell their stories. The acceptability of the methodology will add to the validity and trustworthiness of the findings. Conclusion Given the extent and persistence of ethnic disparities in childhood asthma management, it is imperative that an indigenous approach be taken to understanding the core issues facing Māori families. By

  11. Study on distribution of terminal branches of the facial nerve in mimetic muscles (orbicularis oculi muscle and orbicularis oris muscle).

    Science.gov (United States)

    Mitsukawa, Nobuyuki; Moriyama, Hiroshi; Shiozawa, Kei; Satoh, Kaneshige

    2014-01-01

    There have been many anatomical reports to date regarding the course of the facial nerve to the mimetic muscles. However, reports are relatively scarce on the detailed distribution of the terminal branches of the facial nerve to the mimetic muscles. In this study, we performed detailed examination of the terminal facial nerve branches to the mimetic muscles, particularly the branches terminating in the orbicularis oculi muscle and orbicularis oris muscle. Examination was performed on 25 Japanese adult autopsy cases, involving 25 hemifaces. The mean age was 87.4 years (range, 60-102 years). There were 12 men and 13 women (12 left hemifaces and 13 right hemifaces). In each case, the facial nerve was exposed through a preauricular skin incision. The main trunk of the facial nerve was dissected from the stylomastoid foramen. A microscope was used to dissect the terminal branches to the periphery and observe them. The course and distribution were examined for all terminal branches of the facial nerve. However, focus was placed on the course and distribution of the zygomatic branch, buccal branch, and mandibular branch to the orbicularis oculi muscle and orbicularis oris muscle. The temporal branch was distributed to the orbicularis oculi muscle in all cases and the marginal mandibular branch was distributed to the orbicularis oris muscle in all cases. The zygomatic branch was distributed to the orbicularis oculi muscle in all cases, but it was also distributed to the orbicularis oris muscle in 10 of 25 cases. The buccal branch was not distributed to the orbicularis oris muscle in 3 of 25 cases, and it was distributed to the orbicularis oculi muscle in 8 cases. There was no significant difference in the variations. The orbicularis oculi muscle and orbicularis oris muscle perform particularly important movements among the facial mimetic muscles. According to textbooks, the temporal branch and zygomatic branch innervate the orbicularis oculi muscle, and the buccal branch

  12. 西汉梁国辞赋论略%Analysis on Ci Fu of Liang State in the Xi Han Dynasty

    Institute of Scientific and Technical Information of China (English)

    陈功文

    2015-01-01

    受梁孝王喜爱辞赋的影响,西汉梁园文人集团皆善辞赋,西汉梁国辞赋创作逐渐走向繁荣。贾谊的《旱云赋》、枚乘的《梁王菟园赋》及忘忧馆七赋是骚体赋向汉大赋过渡性质的作品。而枚乘与司马相如的大赋创作,不仅将梁园辞赋创作逐步推向了高峰,同时也将汉赋定型并推向了成熟,从而使汉赋成为一代之文学。%Influenced by the King of Liang's love for Ci Fu, Literati in the Xi Han Dynasty were all good at writing Ci Fu, which brought literary creation of Ci Fu to prosperity.Jia Yi's Han Yun Fu, Mei Cheng's Liang Wang Tu Yuan Fu and Lotus Hall Seven Fu were transitional works from Sao Ti Fu to Han Da Fu.Mei Cheng and Sima Xiangru's Fu creation, not only brought Ci Fu creation gradually to the peak, also promoted Han Fu to be mature. The result was that the Han Fu has become a generation of literature.

  13. A multicentre, randomised phase III trial comparing protracted venous infusion (PVI) 5-fluorouracil (5-FU) with PVI 5-FU plus mitomycin C in patients with inoperable oesophago-gastric cancer.

    Science.gov (United States)

    Tebbutt, N C; Norman, A; Cunningham, D; Iveson, T; Seymour, M; Hickish, T; Harper, P; Maisey, N; Mochlinski, K; Prior, Y; Hill, M

    2002-10-01

    This randomised study compared protracted venous infusion (PVI) fluorouracil (5-FU) with PVI 5-FU plus mitomycin C (MMC) in patients with advanced oesophago-gastric cancer. Two hundred and fifty-four patients with adenocarcinoma, squamous cell carcinoma or undifferentiated carcinoma involving the oesophagus, oesophago-gastric junction or the stomach were randomised. The major end points were tumour response, survival, toxicity and quality of life. The median age of patients treated was 72 years and the two arms were well-balanced for baseline demographic factors. The overall response rate was 16.1% [95% confidence interval (CI) 9.5% to 22.7%] in patients treated with PVI 5-FU alone compared with 19.1% (95% CI 12.0% to 26.0%) for those treated with PVI 5-FU plus MMC (P = 0.555). Median time to treatment failure was 3.9 months for PVI 5-FU and 3.8 months for PVI 5-FU plus MMC (P = 0.195). Median survival was 6.3 months for PVI 5-FU and 5.3 months for PVI 5-FU plus MMC (P = 1.0). Toxicity was mild for both treatments. Symptomatic benefit measured by improvement in pain control, weight loss, dysphagia and oesophageal reflux was observed in over 64% of patients in each arm. Quality of life scores were comparable in each arm. PVI 5-FU is a safe, effective form of palliation for patients with advanced oesophago-gastric cancer although the addition of MMC adds little extra benefit.

  14. Socialisation et dépendance. Théories de l’impérialisme chez Luciano Ferrari Bravo et Giovanni Arrighi

    OpenAIRE

    Melegari, Diego

    2016-01-01

    L’article compare les positions de Luciano Ferrari Bravo et Giovanni Arrighi à la fin des années 1970, notamment en ce qui concerne la théorie de l’impérialisme et la relation théorie-politique.

  15. Multiple origin usage for DNA replication in sdrA(rnh) mutants of Escherichia coli K-12. Initiation in the absence of oriC.

    Science.gov (United States)

    de Massy, B; Fayet, O; Kogoma, T

    1984-09-15

    In stable DNA replication (sdrA/rnh) mutants of Escherichia coli, initiation of rounds of DNA replication occurs in the absence of the normal origin of replication, oriC. To determine whether or not the initiation occurs at a fixed site(s) on the chromosome in sdrA mutants, the DNA from exponentially growing sdrA mutant cells with or without the oriC site (delta oriC) was analyzed for the relative copy numbers of various genes along the chromosome. The results suggest that there are at least four fixed sites or regions of the sdrA delta oriC chromosome from which DNA replication can be initiated in the absence of the oriC sequence.

  16. [Establishment of a human laryngeal carcinoma Hep-2/5-Fu cell line and the screening of differentially expressed genes].

    Science.gov (United States)

    Chen, Jie; Wang, Jiadong

    2012-12-01

    To establish a Hep-2/5-Fu of human drug-resistant laryngeal carcinoma cell line, and to screen the possible drug resistance-associated genes. Hep-2/5-Fu of a human drug resistant laryngeal carcinoma cell line was induced by continuously exposing human laryngeal carcinoma cells to gradually increasing concentrations of 5-Fu. The growth law was observed and the growth curve was protracted. The drug resistance of Hep-2/5-Fu was measured by MTT assay and the drug resistant index RI was calculated. Genes expressed differentially between Hep-2/5-Fu and its parent cell line Hep-2 were screened using a gene chip, and several selected drug resistance associated genes were confirmed by reverse transcription-polymerase chain reaction (RT-PCR). Compared with its parental cells, the drug resistance cell line had slower growth rate and larger size. The Hep-2/5-Fu cell line showed cross drug resistance to 5-Fu, cisplatin and vincristine. There were 1210 differentially expressed genes possibly associated with drug resistance by the gene chip screening method. The possible drug resistance-related genes included Cyclin D, IGF-BP3, CASP9, and CDK4/6. The expression of Cyclin D in the Hep-2/5-Fu cell line was 6.5997 times of that in the parent cell line. RT-PCR results were consistent with the gene chip results. The altered biological properties of Hep-2/5-Fu may be related to its drug resistance phenotype. Several genes, such as Cyclin D, are possibly involved in the mechanism of drug resistance in this cell line.

  17. Pre-outburst $Chandra$ Observations of the Recurrent Nova T Pyxidis

    CERN Document Server

    Balman, Solen

    2014-01-01

    I present a total of 98.8 ksec ($\\sim$ 3$\\times$30 ksec) observation of T Pyx with the ACIS-S3 detector on-board the $Chandra$ Observatory obtained during the quiescent phase, about 2-3 months before its outburst in April 2011. The total $Chandra$ spectrum of the source T Pyx gives a maximum temperature kT$_{max}$$>$ 37.0 keV with (0.9-1.5)$\\times 10^{-13}$ erg s$^{-1}$ cm$^{-2}$ and (1.3-2.2)$\\times$10$^{32}$ erg s$^{-1}$ (at 3.5 kpc) in the 0.1-50 keV range using a multi-temperature plasma emission model (i.e., CEVMKL in XSPEC). I find a ratio of (L$_{x}$/L$_{disk}$)$\\simeq$(2-7)$\\times$10$^{-4}$ indicating considerable inefficiency of emission in the boundary layer. There is no blackbody emission with 2$\\sigma$ upper limits kT$_{BB}$$<$ 25 eV and L$_{soft}$$<$ 2.0$\\times$10$^{33}$ erg s$^{-1}$ in the 0.1-10.0 keV band. All fits yield only interstellar N${\\rm _H}$ during quiescence. I suggest that T Pyx has an optically thin boundary layer (BL) merged with an ADAF-like flow (Advection-Dominated Flow) ...

  18. Quality of life in patients with advanced gastric cancer: a randomized trial comparing docetaxel, cisplatin, 5-FU (TCF with epirubicin, cisplatin, 5-FU (ECF

    Directory of Open Access Journals (Sweden)

    Montazeri Ali

    2006-12-01

    Full Text Available Abstract Background Health related quality of life (HRQOL is an important outcome after treatment for upper gastrointestinal carcinoma. This study aimed to compare HRQOL in patients with advanced gastric cancer (GC receiving either a standard or an experimental treatment. Methods Seventy-one patients have been treated in Cancer Institute (Tehran, Iran with docetaxel, cisplatin, 5 FU (TCF or epirubicin, cisplatin, 5-FU (ECF and were followed from Jan 2002 to Jan 2005. End points were response rate, HRQOL and survival. HRQOL was assessed using the EORCT QLQ-C30 at baseline and after the third cycle of chemotherapy. Results The baseline HRQOL scores were comparable between two groups. After treatment improvement was seen in a number of items and domains except for cognitive functioning, and diarrhoea. Pain decreased and physical functioning improved in both groups. However, only the TCF group showed statistically and clinically meaningful improvement in global QOL (P = 0.001. Surgical and pathologic response was better with TCF but there was no difference in survival rate between two groups. Conclusion Docetaxel based treatment (TCF showed better palliation and improvement of global QOL as compared with epirubicin based treatment (ECF. However, it seems that regardless of treatment offered, effective chemotherapy was the most important factor affecting QOL in these patients.

  19. Draft genome sequence of Chelonobacter oris strain 1662T, associated with respiratory disease in Hermann’s tortoises

    DEFF Research Database (Denmark)

    Kudirkiene, Egle; Hansen, Mie Johanne; Bojesen, Anders Miki

    2014-01-01

    Chelonobacter oris 1662T is a type strain of the recently described species of the Pasteurellaceae family. The strain was isolated from the choanae of a captive tortoise with signs of respiratory tract infection. The genome reported here is approximately 2.6 Mb in size and has a G+C content of 47.1%....

  20. Whānau Ora; He Whakaaro Ā Whānau: Māori Family Views of Family Wellbeing

    Directory of Open Access Journals (Sweden)

    Amohia F. Boulton

    2014-04-01

    Full Text Available This article presents the findings from two studies that investigated the concept of whānau ora (family wellbeing: One examined the nature of resilience for Māori whānau and how resilience relates to whānau ora; while the second investigated the impact of the Working for Families policy on Māori families’ perceptions of whānau ora. In each study, Māori were asked to define whānau ora for their family. The responses to the “whānau ora” definition question in each of the studies were separated out to derive a unique dataset of 46 whānau definitions of whānau ora. A secondary analysis of responses was undertaken specifically for this article and these were compared to the whānau ora outcome definition outlined in the Report of the Taskforce on Whānau-Centred Initiatives (Taskforce on Whānau-Centred Initiatives, 2010. The degree of concordance between the definitions of whānau ora expressed by Māori families and those espoused by the government’s Taskforce is outlined. The article discusses the variability in understandings around whānau ora and the implications of our analysis for social service delivery and social policy development.

  1. Rien ne va plus en physique ! l'échec de la théorie des cordes

    CERN Document Server

    Smolin, Lee

    2007-01-01

    Depuis quelques décennies, une théorie merveilleuse enthousiasme les physiciens : la théorie des cordes, qui stipule (en bref) que les particules élémentaires - électrons, quarks, etc. - ne seraient pas ponctuelles mais semblables à de minuscules cordes vibrantes : chaque vibration correspondrait à une particule, comme chaque fréquence sonore définit une note de musique. Aussi poétique soit cette vision de la matière, elle présente un inconvénient majeur, celui de se prêter très mal à l'expérimentation. Elle reste donc une théorie virtuelle dont l'impact est surtout d'ordre sociologique : le gratin de la physique mondiale abonde en "cordistes", au détriment des spécialistes d'autres domaines, et la physique a vu ses crédits focalisés dans une direction trop théorique. Lee Smolin, physicien réputé, explique à la fois les promesses de la théorie et les excès auxquels elle a mené, sans omettre de formuler quelques recettes pour que la science ne retombe plus dans une telle ornière.

  2. Complete Genome Sequence of Lactobacillus oris J-1, a Potential Probiotic Isolated from the Human Oral Microbiome

    Science.gov (United States)

    2016-01-01

    Lactobacilli can exert health-promoting effects in the human oral microbiome through many mechanisms, including pathogen inhibition, maintenance of microbial balance, immunomodulation, and enhancement of the epithelial barrier function. Here, we present the complete genome sequence of a potential probiotic, Lactobacillus oris J-1, that was isolated from the oral cavity of a health child. PMID:27634996

  3. Discovery of Multi-target Anticancer Agents Based on HDAC Inhibitor MS-275 and 5-FU.

    Science.gov (United States)

    Jiang, Yuqi; Li, Xiaoguang; Li, Xiaoyang; Hou, Jinning; Ding, Yongzheng; Zhang, Jian; Xu, Wenfang; Zhang, Yingjie

    2016-01-01

    Histone deacetylases (HDACs) inhibitors have multiple effects targeting the cancer cells and have become one of the promising cancer therapeutics with possibly broad applicability. Combination of HDAC inhibitors with the cytotoxic fluorouracil (5-FU) showed additive and synergistic effects both in vitro and in vivo. To explore the possibility in cancer therapy of a bivalent agent that combines two bioactive groups within a single molecular architecture, we designed and synthesized new dual-acting compounds by combining the bioactive fragment of MS-275, a clinical HDACs inhibitor, with cytotoxic agent 5-FU. The target compounds 9a and 9b showed comparable HDACs inhibition with MS-275 and moderate antiproliferative acitivities against six cancer cells lines.

  4. Evaluation of preoperative radiation therapy in combination with low dose carboplatin and 5FU

    Energy Technology Data Exchange (ETDEWEB)

    Yokomizo, Michinori; Tada, Hiroyuki; Ishikawa, Kazuo; Togawa, Kiyoshi [Akita Univ. (Japan). School of Medicine; Okamoto, Yoshitaka; Matsuzaki, Zensei

    1997-10-01

    A comparative study was performed to evaluate difference in the histological effects and side effects between a group of tongue cancer and hypopharyngeal cancer patients treated with 5FU (250 mg x 3 days/week) and 60 Gy radiation, and those treated with CBDCA (50-80 mg x 1 day/week) followed by 5FU (250 mg x 2 days/week) and 40 Gy radiation. In the tongue cancer patients, there was no significant change in histological effects according to Shimosato`s classification system. A decrease in leukocytes was found in the CBDCA group, which was not statistically significant. In cases with hypopharyngeal cancer, the number of leukocytes was significantly decreased in the CBDCA group. However the number of platelets and degree of stomatitis was not significantly altered. (author)

  5. COMBINATION OF 5-FU AND EPIRUBICIN IN THE TREATMENT OF ADVANCED GASTRIC CANCER

    Directory of Open Access Journals (Sweden)

    Ardeshir Ghavamzadeh

    1993-06-01

    Full Text Available This study was undertaken to assess the effectiveness of 5-FU plus epirubicin in the treatment of the advanced gastric cancer. For this purpose, 22 patients with no previous treatment were studied. All of the patients were unoperable or metastatic. Follow up checking continued for 24 months. Our selected therapeutic regimen consisted of a combination of 500 mg/m2 5-FU dialy for five days, and 75 mg/m2 epirubicin for one day. The response rate in this study was 47.4% and the mean survival rate was 9.7 months. By far, the most common complication was gastrointestinal disturbances and no carditoxicity was seen. Having presented the results of this study and comparing it with the other therapeutic regimens like FAM combination, this selected two drug combination seems to be a useful therapeutic protocol.

  6. Last gasp of V1647 Ori: a brief post-outburst warm, molecular wind

    Science.gov (United States)

    Brittain, Sean D.; Simon, Theodore; Rettig, Terrence W.; Gibb, Erika L.; Balsara, Dinshaw; Tilley, David; Hinkle, Kenneth H.

    2007-05-01

    Followup infrared spectroscopy is reported for V1647 Ori, a young star whose recent eruption illuminated McNeil's Nebula. Lines of HI, H2, and CO are compared to previous observations. We find that the accretion rate fell two orders of magnitude and the CO bandheads disappeared at the end of the outburst. We also report a striking metamorphosis of the fundamental CO spectrum from centrally peaked profiles to emission lines with superimposed blue-shifted absorption lines and back again one year later. This remarkable change in spectral appearance indicates that the system did not return to equilibrium immediately following the outburst. In this paper we propose a mechanism to explain the emergence of a transient post-outburst outflow.

  7. Ricœur et la théorie de l’action

    Directory of Open Access Journals (Sweden)

    Jean-Luc Petit

    2014-07-01

    Full Text Available  AbstractRicoeur’s Philosophy of the Will is reexamined here both as a source of motivation for his project of dialoguing with the analytic theory of action and as an explanation for the lack of response on the part of his Anglo-American interlocutors.Keywords: Actions, Language, Body, Idealism. RésuméLa Philosophie de la volonté de Ricœur est revisitée ici comme source de motivation de son entreprise de dialogue avec la théorie analytique de l’action et comme explication du défaut de réponse de ses interlocuteurs anglo-américains.Mots-clés: Actions, Langage, Corps, Idéalisme.

  8. Deux théories de l'analyse psychique: Wundt et Brentano

    OpenAIRE

    Dewalque, Arnaud

    2014-01-01

    L’objectif de ce chapitre est de réévaluer succinctement les relations entre la phénoménologie et la psychologie expérimentale naissantes à partir des positions de Franz Brentano et de Wilhelm Wundt. Contrairement à une idée reçue, je suggère, d’une part, que les programmes analytiques de Brentano et de Wundt reposent tous deux sur un procédé expérimental consistant à faire varier les parties des phénomènes psychiques étudiés. Mais je suggère aussi, d’autre part, que les théories de l’analyse...

  9. Bases Mathématiques de la théorie des jeux

    OpenAIRE

    Laraki, Rida; Renault, Jérôme; Sorin, Sylvain

    2013-01-01

    International audience; Cet ouvrage est destiné aux étudiants en master ainsi qu'aux étudiants des écoles d'ingénieurs. Les connaissances mathématiques requises sont celles d'une licence scientifique. Ce cours est consacré à une présentation des principaux concepts et outils mathématiques de la théorie des jeux stratégiques. L'accent est mis sur l'exposé et les preuves des résultats fondamentaux (minmax et opérateur valeur, équilibre de Nash et corrélé). Par ailleurs certains développements r...

  10. Special article: airway management in reconstructive surgery for noma (cancrum oris).

    Science.gov (United States)

    Coupe, Michael Howard; Johnson, Doug; Seigne, Patrick; Hamlin, Bill

    2013-07-01

    Noma (cancrum oris) is a disease of poverty and malnutrition, which predominantly affects children younger than 10 years in developing countries. Although the majority of sufferers die of sepsis at the time of the initial infection, or of subsequent starvation due to severe trismus and an inability to eat, a small minority of patients survive and require reconstructive surgery for severe facial scarring and deformity. These patients present significant problems to the anesthesiologist with regard to airway management. We present a series of 26 patients undergoing primary and subsequent reconstructive surgery, with particular focus on airway management. We show that airway management, while challenging, can be performed safely and successfully by using individualized airway plans but may require advanced techniques and equipment. Traditional tests focusing on the anterior/superior airway are helpful in assessing patients with facial deformity due to noma.

  11. The AKARI FU-HYU galaxy evolution program: first results from the GOODS-N field

    Science.gov (United States)

    Pearson, C. P.; Serjeant, S.; Negrello, M.; Takagi, T.; Jeong, W.-S.; Matsuhara, H.; Wada, T.; Oyabu, S.; Lee, H. M.; Im, M. S.

    2010-05-01

    The AKARI FU-HYU mission program carried out mid-infrared imaging of several well studied Spitzer fields preferentially selecting fields already rich in multi-wavelength data from radio to X-ray wavelengths filling in the wavelength desert between the Spitzer IRAC and MIPS bands. We present the initial results for the FU-HYU survey in the GOODS-N field. We utilize the supreme multiwavelength coverage in the GOODS-N field to produce a multiwavelength catalogue from infrared to ultraviolet wavelengths, containing more than 4393 sources, including photometric redshifts. Using the FU-HYU catalogue we present colour-colour diagrams that map the passage of PAH features through our observation bands. We find that the longer mid-infrared bands from AKARI (IRC-L18W 18 micron band) and Spitzer (MIPS24 24 micron band) provide an accurate measure of the total MIR emission of the sources and therefore their probable total mid-infrared luminosity. We also find that colours incorporating the AKARI IRC-S11 11 micron band produce a bimodal distribution where an excess at 11 microns preferentially selects moderate redshift star-forming galaxies. These powerful colour-colour diagnostics are further used as tools to extract anomalous colour populations, in particular a population of Silicate Break galaxies from the GOODS-N field showing that dusty starbursts can be selected of specific redshift ranges (z = 1.2-1.6) by mid-infrared drop-out techniques. The FU-HYU catalogue will be made publically available to the astronomical community.

  12. Posmodernisme Dalam Novel Generation X: Tales For Accelerated Culture Dan Bilangan Fu

    OpenAIRE

    Azmi, Nurul Nayla; Zein, Thirhaya

    2015-01-01

    This research is entitled Postmodernism in Novel Generation X: Tale of Accelerated Culture and Bilangan Fu which analyze postmodernism as the concept in both novel. This research is analyzed the postmodernism by theory of postmodernism by Baudrillard which divide it into two concept, they are simulacra and hyper reality. The method which is used in this research is descriptive qualitative. The data from this research is word, phrase,clause, nor sentence that found in the both object novel ...

  13. [A case of recurrent biliary cystadenocarcinoma successfully treated with 5FU/CDDP systemic chemotherapy].

    Science.gov (United States)

    Iyama, Satoshi; Takahashi, Yasuo; Shintani, Naoaki; Fujikawa, Koshi; Ohkubo, Syunichi; Sato, Yasushi; Sato, Tsutomu; Sato, Yasuhiro; Ohnuma, Keisuke; Niitsu, Yoshiro

    2006-10-01

    We report a case of biliary cystadenocarcinoma which recurred 41 months postoperatively. A 60-year-old woman was admitted for further examination of multiple metastatic tumors and a large amount of ascites. Systemic administration of 5FU and CDDP caused her CEA level to decrease gradually and abdominal computed tomography revealed considerable reduction of the metastatic tumors and ascites. Since her general condition had improved, chemotherapy was continued in the outpatient clinic.

  14. Effect of 5-FU on modulation of disarrangement of immuneassociated cytokines in experimental acute pancreatitis

    Institute of Scientific and Technical Information of China (English)

    Xiao-Li Chen; Sang-Zhu Ciren; Hui Zhang; Li-Geng Duan; Alexander J Wesley

    2009-01-01

    AIM: To investigate the effects of 5-Fluorouracil (5-FU)on modulation of pro-inflammatory and anti-inflammatory cytokines in acute pancreatitis and the mechanism of it in the treatment of acute pancreatitis.METHODS: Male Sprague Dawley rats were assigned to 3 Groups: Group A, sham operated rats as controls ( n = 7); Group B, acute pancreatitis induced by ductal injection with 5% sodium cholate at a volume of 1.0 mL/kg without any other treatment; Group C, after the pancreatitis was induced as in Group B, the rats were injected intravenously with 5-FU 40 mg/kg. The animals in Groups B and C were killed at 2, 6 and 24 h after operation ( n = 7), and blood samples were taken for measurement of tumor necrosis factor-α (TNF-α),interleukin-1 (IL-1), interleukin-6 (IL-6) (by bioassay),and interleukin-10 (IL-10), transforming growth factor-β (TGF-β) (by ELISA). The wet weight of pancreatic tissue, serum amylase levels and white blood cells were also measured.RESULTS: Four rats in Group B and one in Group C died after pancreatitis was induced. Both pro-inflammatory cytokines (TNF-α, IL-1, IL-6) at the 2 and 6 h period and the anti-inflammatory cytokines (IL-10,TGF-β) at 24 h increased significantly ( P < 0.05) in rats of Group B. After treatment with 5-FU, TNF-α, IL-1, and IL-6 in serum of rats of Group C were inhibited at 2 and 6 h after operation ( P < 0.05), and IL-10, TGF-β were inhibited at 24 h compared to Group B ( P < 0.05). Obvious improvements in the severity of the acute pancreatitis,including the amylase levels, wet weight of pancreatic tissue and neutrophil counts, were also observed after treatment with 5-FU.

  15. Le big bang n'est pas une théorie comme les autres

    CERN Document Server

    Bonnet-Bidaud, Jean-Marc; Leglu, Dominique; Reinisch, Gilbert

    2009-01-01

    Le big bang n'est pas une théorie comme les autres. Ce n'est d'ailleurs pas une théorie physique au sens propre du terme, mais un scénario cosmologique issu des équations de la relativité générale. Il est le modèle qui s'ajuste le mieux aux observations actuelles, mais à quel prix ? Il nous livre un Univers composé à 96 % de matière et d'énergie noires inconnues. C'est donc un euphémisme que de dire que le big bang semble poser autant - sinon plus - de questions qu'il n'en résout. En ce sens, le big bang apparaît davantage comme une paramétrisation de notre ignorance plutôt que comme une modélisation d'un phénomène. Pourtant, le succès du big bang et l'adhésion qu'il suscite, tant dans la sphère scientifique que dans la sphère médiatique, ne se démentent pas. Surmédiatisé, son statut dépasse celui de modèle théorique, et la simple évocation de son nom suffit pour justifier des opérations de marketing scientifique ou rejeter des cosmologies alternatives. Pour éclaircir les pr...

  16. Ethnic density and area deprivation: neighbourhood effects on Māori health and racial discrimination in Aotearoa/New Zealand.

    Science.gov (United States)

    Bécares, Laia; Cormack, Donna; Harris, Ricci

    2013-07-01

    Some studies suggest that ethnic minority people are healthier when they live in areas with a higher concentration of people from their own ethnic group, a so-called ethnic density effect. To date, no studies have examined the ethnic density effect among indigenous peoples, for whom connections to land, patterns of settlement, and drivers of residential location may differ from ethnic minority populations. The present study analysed the Māori sample from the 2006/07 New Zealand Health Survey to examine the association between increased Māori ethnic density, area deprivation, health, and experiences of racial discrimination. Results of multilevel regressions showed that an increase in Māori ethnic density was associated with decreased odds of reporting poor self-rated health, doctor-diagnosed common mental disorders, and experienced racial discrimination. These associations were strengthened after adjusting for area deprivation, which was consistently associated with increased odds of reporting poor health and reports of racial discrimination. Our findings show that whereas ethnic density is protective of the health and exposure to racial discrimination of Māori, this effect is concealed by the detrimental effect of area deprivation, signalling that the benefits of ethnic density must be interpreted within the current socio-political context. This includes the institutional structures and racist practices that have created existing health and socioeconomic inequities in the first place, and maintain the unequal distribution of concentrated poverty in areas of high Māori density. Addressing poverty and the inequitable distribution of socioeconomic resources by ethnicity and place in New Zealand is vital to improving health and reducing inequalities. Given the racialised nature of access to goods, services, and opportunities within New Zealand society, this also requires a strong commitment to eliminating racism. Such commitment and action will allow the benefits

  17. Ethnic density and area deprivation: Neighbourhood effects on Māori health and racial discrimination in Aotearoa/New Zealand

    Science.gov (United States)

    Bécares, Laia; Cormack, Donna; Harris, Ricci

    2013-01-01

    Some studies suggest that ethnic minority people are healthier when they live in areas with a higher concentration of people from their own ethnic group, a so-called ethnic density effect. To date, no studies have examined the ethnic density effect among indigenous peoples, for whom connections to land, patterns of settlement, and drivers of residential location may differ from ethnic minority populations. The present study analysed the Māori sample from the 2006/07 New Zealand Health Survey to examine the association between increased Māori ethnic density, area deprivation, health, and experiences of racial discrimination. Results of multilevel regressions showed that an increase in Māori ethnic density was associated with decreased odds of reporting poor self-rated health, doctor-diagnosed common mental disorders, and experienced racial discrimination. These associations were strengthened after adjusting for area deprivation, which was consistently associated with increased odds of reporting poor health and reports of racial discrimination. Our findings show that whereas ethnic density is protective of the health and exposure to racial discrimination of Māori, this effect is concealed by the detrimental effect of area deprivation, signalling that the benefits of ethnic density must be interpreted within the current socio-political context. This includes the institutional structures and racist practices that have created existing health and socioeconomic inequities in the first place, and maintain the unequal distribution of concentrated poverty in areas of high Māori density. Addressing poverty and the inequitable distribution of socioeconomic resources by ethnicity and place in New Zealand is vital to improving health and reducing inequalities. Given the racialised nature of access to goods, services, and opportunities within New Zealand society, this also requires a strong commitment to eliminating racism. Such commitment and action will allow the benefits

  18. The AKARI FU-HYU galaxy evolution program: First results from the GOODS-N field

    CERN Document Server

    Pearson, C P; Negrello, M; Takagi, T; Jeong, W -S; Matsuhara, H; Wada, T; Oyabu, S; Lee, H M; Im, M S

    2010-01-01

    The AKARI FU-HYU mission program carried out mid-infrared imaging of several well studied Spitzer fields preferentially selecting fields already rich in multi-wavelength data from radio to X-ray wavelengths filling in the wavelength desert between the Spitzer IRAC and MIPS bands.We present the initial results for the FU-HYU survey in the GOODS-N field.We utilize the supreme multiwavelength coverage in the GOODS-N field to produce a multiwavelength catalogue from infrared to ultraviolet wavelengths, containing more than 4393 sources, including photometric redshifts. Using the FU-HYU catalogue we present colour-colour diagrams that map the passage of PAH features through our observation bands. We find that the longer mid-infrared bands from AKARI (IRC-L18W 18 micron band) and Spitzer (MIPS24 24 micron band) provide an accurate measure of the total MIR emission of the sources and therefore their probable total mid-infrared luminosity. We also find that colours incorporating the AKARI IRC-S11 11 micron band produ...

  19. The Near-Contact Binary FU Ara: New Observations, a Photometric Study and Preliminary Elements

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A new CCD (V) light curve is presented for'the semi-detached binary system FU Ara. The light curve, obtained in 2007, is the first one since the last 50 years. With our data we were able to determine six new times of minimum light and refined the period of the system to 0.8645049 days. A Wilson-Devinney analysis leads to a solution of a semi-detached configuration, composed of a main-sequence primary component of spectral type F5, fractionally smaller than its Roche lobe, and an evolved secondary component of spectral type K I which fills its Roche lobe, and which is overluminous and oversized as compared with the main-sequence. The two components of FU Ara differ considerably in effective temperature. It is classified as an FO Virginis type of near-contact binary system. Assuming a reasonable value for the mass of the primary component, an estimate of the absolute elements of FU Ara has been made, on the assumption that the primary has a mass corresponding to its spectral type according to Svechnikov & Taidakova.

  20. Development and characterization of 5-FU bearing ferritin appended solid lipid nanoparticles for tumour targeting.

    Science.gov (United States)

    Jain, Sanjay K; Chaurasiya, Akash; Gupta, Yashwant; Jain, Anekant; Dagur, Pradeep; Joshi, Beenu; Katoch, Vishwa M

    2008-08-01

    Ferritin coupled solid lipid nanoparticles were investigated for tumour targeting. Solid lipid nanoparticles were prepared using HSPC, cholesterol, DSPE and triolien. The SLNs without ferritin which has similar lipid composition were used for comparison. SLNs preparations were characterized for shape, size and percentage entrapment. The average size of SLNs was found to be in the range 110-152 nm and maximum drug entrapment was found to be 34.6-39.1%. In vitro drug release from the formulations is obeying fickian release kinetics. Cellular uptake and IC50 values of the formulation were determined in vitro in MDA-MB-468 breast cancer cells. In vitro cell binding of Fr-SLN exhibits 7.7-folds higher binding to MDA-MB-468 breast cancer cells in comparison to plain SLNs. Ex-vivo cytotoxicity assay on targeted nanoparticles gave IC50 of 1.28 microM and non-targeted nanoparticles gave IC50 of 3.56 microM. In therapeutic experiments, 5-FU, SLNs and Fr-SLNs were administered at the dose of 10 mg 5-FU/kg body weight to MDA-MB-468 tumour bearing Balb/c mice. Administration of Fr-SLNs formulation results in effective reduction in tumour growth as compared with free 5-FU and plain SLNs. The result demonstrates that this delivery system possessed an enhanced anti-tumour activity. The results warrant further evaluation of this delivery system.

  1. The Recovery Process of Murine Tracheal Epithelium Injured by 5-FU and Its Microarray Analysis

    Directory of Open Access Journals (Sweden)

    Jingru ZHANG

    2009-02-01

    Full Text Available Background and objective Although there are increasing reports on localization of tracheal stem cells, the mechanism of proliferation and differentiation of tracheal stem cells remains unclear. Methods In this study, we developed an ex vivo model of murine tracheal epithelial injury and regeneration induced by 5-FU. The regenerationprocess of murine tracheal epithelium was observed and analyzed by morphological, immunofluorescence and microarray methods. Results After treatment with 5-FU, the differentiated mature cells were dead and desquamated. Only a few cells remained in G0 phase and located on the basement membrane. After being put back in normal culture media, the cells became flat, cubic and restored as pseudostratified epithelium at last. These G0 phase cells were ABCG2 positive. We detected the differences of stem cell genes between normal tracheal epithelial cells and regenerated epithelial cells at 24 h and 48 h after injured by 5-FU using stem cell differentiation gene microarray. At 24 h, 8 genes were up-regulated and 31 genes were down-regulated. At 48 h, 5 genes were up-regulated and 42 genes were down-regulated. Conclusion The differently expressed genes were mainly associated with cell cycle regulation, intercellular junction, FGF, BMP, Notch and Wnt signaling pathways, which suggested these alterations might be closely associated with the proliferation and differentiation of tracheal stem cells.

  2. Fu-Chan Wei—Surgeon, Innovator, and Leader of the Legendary Chang Gung Microsurgery Center

    Science.gov (United States)

    AL Deek, Nidal Farhan

    2016-01-01

    Fu-Chan Wei is a world-renowned plastic and reconstructive surgeon. He is clearly one of the most influential and innovative surgeons in the history of plastic surgery. The Taiwanese legend is the innovator of the osteoseptocutaneous fibula flap, which revolutionized the reconstruction of composite bone and soft tissue defects in the jaw and extremities. He has pioneered several perforator flaps, including the free style variety. He has taken toe-to-hand microsurgical transplantation to a whole new level. He is not only recognized for his surgical skills and clinical innovations, but also for his vision, leadership, and teaching. The establishment and development of the famous Microsurgery Center at Chang Gung Memorial Hospital is unparalleled anywhere. The international fellowship program in microsurgery there remains the envy of all microsurgical trainees. Dr. Wei and his colleagues have trained and influenced more than 1,500 surgeons from all over the world. The aim of this video article is to share what we learned by interviewing Fu-Chan Wei at Chang Gung. The story of Fu Chan Wei, his colleagues, and the development of the Microsurgery Center in Taiwan is worth knowing. PMID:27757352

  3. Patterns of endemism along an elevation gradient in Sierra Nevada (Spain and Lefka Ori (Crete, Greece

    Directory of Open Access Journals (Sweden)

    Fernández-Calzado, R.

    2013-12-01

    Full Text Available Aim: High mountains in the Mediterranean region of Europe are particularly rich in endemic vascular plants. We aimed to compare the altitudinal patterns of vascular plant species richness and the proportion of endemic species in two Mediterranean region: Lefka Ori on the island of Crete (Greece and Sierra Nevada on the Iberian peninsula. Location: Sierra Nevada, Granada (Spain; Lefka Ori, Crete (Greece. Methods: Data from standardised permanent plots settings on summit sites (comprising eight plot sectors, covering the upeermost 10 altitudinal metres of different elevations were used (GLORIA Multi-Summit approach; www.gloria.ac.at. Species numbers, rates of endemic species, and soils temperature were compared by means of ANCOVA and linear regression. Results: The two regions, though climatically similar, showed strikingly different patterns: In Sierra Nevada, the proportion of endemic vascular plants (species restricted to Sierra Nevada showed a stepwise increase from the lowest to the highest summit. In contrast, the proportion of endemic species restricted to Crete was not significantly different between the four summits in Lefka Ori. In both regions the observed trends were largely consistent with the altitudinal distribution of the endemic species obtained from standard floras. Main conclusions: The geographic positions of the two regions, i.e. island versus mainland and the higher elevation of Sierra Nevada are suggested to be the primary causes of the observed differences. The high degree of endemism in the cold environments of Mediterranean mountains’ upper bioclimatic zones indicates a pronounced vulnerability to the impacts of climate change. A continued and intensified species monitoring in the mountains around the Mediterranean basin, therefore, should be considered as a priority research task.Objetivo: Las zonas de alta montaña en la región mediterránea europea son particularmente ricas en plantas vasculares end

  4. A randomised phase III trial of adjuvant radio-chemotherapy comparing Irinotecan, 5FU and Leucovorin to 5FU and Leucovorin in patients with rectal cancer: a Hellenic Cooperative Oncology Group Study.

    Science.gov (United States)

    Kalofonos, H P; Bamias, A; Koutras, A; Papakostas, P; Basdanis, G; Samantas, E; Karina, M; Misailidou, D; Pisanidis, N; Pentheroudakis, G; Economopoulos, T; Papadimitriou, C; Skarlos, D V; Pectasides, D; Stavropoulos, M; Bafaloukos, D; Kardamakis, D; Karanikiotis, C; Vourli, G; Fountzilas, G

    2008-08-01

    The primary objective was to compare the 3-year survival of rectal cancer patients randomised postoperatively to irinotecan (IRI), Leucovorin (LV) and bolus 5-fluorouracil (5FU) or LV-bolus 5FU with radiotherapy. Secondary objectives included disease-free survival, local relapse and toxicity. The study included 321 eligible patients. The treatment consisted of weekly administration of IRI 80 mg/m(2) intravenously (IV), LV 200 mg/m(2) and 5FU 450 mg/m(2) bolus (arm A) versus LV 200 mg/m(2) and 5FU 450 mg/m(2) IV bolus (arm B). One cycle included four infusions and treatment was continued for a total of six cycles. The first cycle was followed by pelvic irradiation plus 5FU. There were no differences between the arms in 3-year overall, disease-free and local relapse-free survival. Grades 3 and 4 toxicity was similar in both the arms with the exception of leucopaenia, neutropaenia and alopecia, which were higher in the IRI arm. IRI added to adjuvant radiochemotherapy with LV and bolus 5FU was not shown to improve survival, whereas the incidence of severe leucopaenia was significantly higher in the IRI arm.

  5. 奥运风云人物——伏明霞%Glorious People in Olympics History-Fu Mingxia

    Institute of Scientific and Technical Information of China (English)

    姜全红

    2006-01-01

    @@ Fu Mingxia completed a remarkable diving career that earned her the title Queen of Diving. Over a period of three Olympic Games (1992, 1996, 2000) she earned four gold and one silver medals, more than any other diver in history.

  6. RPR-115135, a farnesyltransferase inhibitor, increases 5-FU- cytotoxicity in ten human colon cancer cell lines: role of p53.

    Science.gov (United States)

    Russo, Patrizia; Malacarne, Davide; Falugi, Carla; Trombino, Sonya; O'Connor, Patrick M

    2002-07-20

    A new non peptidic farnesyltransferase inhibitor, RPR-115135, in combination with 5-FU was studied in 10 human colon cancer cell lines (HCT-116, RKO, DLD-1, Colo-320, LoVo, SW-620, HT-29, HCT-15, Colo-205 and KM-12) carrying several mutations but well characterized for p53 and Ras status. We found that there was a slight tendency (not statistically significant) for the p53 inactivated cells to be less sensitive to 5-FU after 6 days continuous treatment. Simultaneous administration of RPR-115135 and 5-FU, at subtoxic concentrations, resulted in a synergistic enhancement of 5-FU cytotoxicity in the p53 wildtype cells (HCT-116, RKO, DLD-1, Colo-320, LoVo). In the p53 mutated cells (SW-620, HT-29, HCT-15, Colo-205, KM-12) the effect was very complicated. In HCT-15 the combination resulted in antagonism, in KM-12 in antagonism or in synergy (at different concentrations) and in SW-620, HT-29 and Colo-205 cells in synergy but only when 5-FU was administered at high concentrations. Growth inhibition could be accounted for on the basis of a specific cell cycle arrest phenotype (G2-M arrest), as assayed by flow cytometry, only in the p53 functioning cell lines. The combination RPR-115135 + 5-FU increases apoptotic events only in these cell lines. In the mutated cell lines no major alterations on cell cycle arrest phenotype and no induction of apoptosis was observed. Although RPR-115135 can potentiate the effect of 5-FU in cells in which p53 function is disrupted, these data suggest strongly that RPR-115135 significantly enhances the efficacy of 5-FU only when p53 is functioning.

  7. Effects of Streptococcus thermophilus TH-4 on intestinal mucositis induced by the chemotherapeutic agent, 5-Fluorouracil (5-FU).

    Science.gov (United States)

    Whitford, Eleanor J; Cummins, Adrian G; Butler, Ross N; Prisciandaro, Luca D; Fauser, Jane K; Yazbeck, Roger; Lawrence, Andrew; Cheah, Ker Y; Wright, Tessa H; Lymn, Kerry A; Howarth, Gordon S

    2009-03-15

    Beneficial bacteria (probiotics) and probiotic-derived factors have the potential to ameliorate disorders of the intestine. The aim of this study was to compare live Streptococcus thermophilus TH-4 (TH-4), dead TH-4 and TH-4 supernatant in rats treated with 5-Fluorouracil. Rats were randomly allocated to five treatment groups (n=8-10): Saline+Water; 5-FU+Skim Milk; 5-FU+Live TH-4; 5-FU+Supernatant TH-4; and 5-FU+Dead TH-4. 5-FU (150mg.kg(-1)) was administered by a single intraperitoneal injection on day 0; animals were killed on day 4. Treatments were administered daily from days -2 to 3 via oro-gastric gavage. Metabolic parameters were measured daily. Blood was obtained by cardiac puncture, and intestinal tissues removed for quantitative and qualitative histological assessment, including: villous height and area; crypt depth and area, mitotic count and crypt fission; biochemical determination of sucrase and myeloperoxidase (MPO) activity; and disease severity scoring. One-way ANOVA statistical analyses were conducted for the majority of outcome measures. Live TH-4 significantly reduced disease severity score by 13% (p5-FU+Skim milk controls. Live and supernatant TH-4 reduced crypt fission by 69% and 48% (p5-FU+Skim Milk controls. No significant differences (p> 0.05) in the occurrence of bacteraemia were evident across all groups. Live TH-4 partially normalised mitotic count and histological severity score in 5-FU treated rats. The inhibitory effect of live TH-4 and TH-4 supernatant on crypt fission suggests therapeutic utility in the prevention of disorders characterised by increased crypt fission, such as colorectal carcinoma.

  8. Drucken Images und mediale Diskurse über afrikanischen Fußball: Paternalismus, Rassismus und neoliberale Bewunderung

    Directory of Open Access Journals (Sweden)

    Kurt Wachter

    2010-03-01

    Full Text Available Die Wahrnehmung des afrikanischen Fußballs und seiner Spieler war und ist sowohl in den Stadien wie in den medialen Darstellungen von rassistischen Images aus der Zeit Kolonialismus geprägt. Der speziell in Europa konstatierbare Aufstieg des afrikanischen Fußballs im Zuge der Ökonomisierung und Globalisierung des Spiels brachte zwar neue Superstars hervor, alte Stereotype leben aber vor Ort wie im medialen Diskurs in transformierter Weise fort.

  9. Drucken Images und mediale Diskurse über afrikanischen Fußball: Paternalismus, Rassismus und neoliberale Bewunderung

    OpenAIRE

    Kurt Wachter

    2010-01-01

    Die Wahrnehmung des afrikanischen Fußballs und seiner Spieler war und ist sowohl in den Stadien wie in den medialen Darstellungen von rassistischen Images aus der Zeit Kolonialismus geprägt. Der speziell in Europa konstatierbare Aufstieg des afrikanischen Fußballs im Zuge der Ökonomisierung und Globalisierung des Spiels brachte zwar neue Superstars hervor, alte Stereotype leben aber vor Ort wie im medialen Diskurs in transformierter Weise fort.

  10. Fu Works of Sadness in Literary Selection%《文选》“哀伤”赋略论

    Institute of Scientific and Technical Information of China (English)

    冯莉

    2012-01-01

    The Fu in Literary Selection is divided into 15 categories according to their topics, in which the number of Fu works under the term of Fu of sadness is the most. The topic of sadness can be traced back to The Book of Songs. With full features in both contents and artistic expression, Fu of sadness is representative. Sadness Fu writings in different historical stages have different characters, not only displaying the development of Fu of sad- hess, but also highlighting the rationality and important value of Literary Selection in selecting articles.%《文选》将赋按照题材分为十五类目,其中"哀伤"一目选赋篇数最多;"哀伤"题材最早可上溯至先秦的《诗经》;"哀伤"赋选文无论在内容题材上还是艺术表现上都极富特色,具有代表性;不同历史阶段哀伤赋创作的不同特征,既呈现了哀伤赋的发展流变,也凸显了《文选》"哀伤"赋选文的合理性和重要价值。

  11. The two Cis-acting sites, parS1 and oriC1, contribute to the longitudinal organisation of Vibrio cholerae chromosome I.

    Directory of Open Access Journals (Sweden)

    Ariane David

    2014-07-01

    Full Text Available The segregation of bacterial chromosomes follows a precise choreography of spatial organisation. It is initiated by the bipolar migration of the sister copies of the replication origin (ori. Most bacterial chromosomes contain a partition system (Par with parS sites in close proximity to ori that contribute to the active mobilisation of the ori region towards the old pole. This is thought to result in a longitudinal chromosomal arrangement within the cell. In this study, we followed the duplication frequency and the cellular position of 19 Vibrio cholerae genome loci as a function of cell length. The genome of V. cholerae is divided between two chromosomes, chromosome I and II, which both contain a Par system. The ori region of chromosome I (oriI is tethered to the old pole, whereas the ori region of chromosome II is found at midcell. Nevertheless, we found that both chromosomes adopted a longitudinal organisation. Chromosome I extended over the entire cell while chromosome II extended over the younger cell half. We further demonstrate that displacing parS sites away from the oriI region rotates the bulk of chromosome I. The only exception was the region where replication terminates, which still localised to the septum. However, the longitudinal arrangement of chromosome I persisted in Par mutants and, as was reported earlier, the ori region still localised towards the old pole. Finally, we show that the Par-independent longitudinal organisation and oriI polarity were perturbed by the introduction of a second origin. Taken together, these results suggest that the Par system is the major contributor to the longitudinal organisation of chromosome I but that the replication program also influences the arrangement of bacterial chromosomes.

  12. The two Cis-acting sites, parS1 and oriC1, contribute to the longitudinal organisation of Vibrio cholerae chromosome I.

    Science.gov (United States)

    David, Ariane; Demarre, Gaëlle; Muresan, Leila; Paly, Evelyne; Barre, François-Xavier; Possoz, Christophe

    2014-07-01

    The segregation of bacterial chromosomes follows a precise choreography of spatial organisation. It is initiated by the bipolar migration of the sister copies of the replication origin (ori). Most bacterial chromosomes contain a partition system (Par) with parS sites in close proximity to ori that contribute to the active mobilisation of the ori region towards the old pole. This is thought to result in a longitudinal chromosomal arrangement within the cell. In this study, we followed the duplication frequency and the cellular position of 19 Vibrio cholerae genome loci as a function of cell length. The genome of V. cholerae is divided between two chromosomes, chromosome I and II, which both contain a Par system. The ori region of chromosome I (oriI) is tethered to the old pole, whereas the ori region of chromosome II is found at midcell. Nevertheless, we found that both chromosomes adopted a longitudinal organisation. Chromosome I extended over the entire cell while chromosome II extended over the younger cell half. We further demonstrate that displacing parS sites away from the oriI region rotates the bulk of chromosome I. The only exception was the region where replication terminates, which still localised to the septum. However, the longitudinal arrangement of chromosome I persisted in Par mutants and, as was reported earlier, the ori region still localised towards the old pole. Finally, we show that the Par-independent longitudinal organisation and oriI polarity were perturbed by the introduction of a second origin. Taken together, these results suggest that the Par system is the major contributor to the longitudinal organisation of chromosome I but that the replication program also influences the arrangement of bacterial chromosomes.

  13. On Comical Literary Technique of Song Fu%论宋赋的滑稽艺术

    Institute of Scientific and Technical Information of China (English)

    刘培

    2015-01-01

    It is rather obvious that there is some inner impulse to entertain the author himself and other people in Cifu creation.Song Fu also attached much importance to comical description.The culture of the Song Dynasty paid close attention to deep cultivation, rational interest and noble moral.These three constitute the basic elements of the comical creation of Song Fu.Most scholar-bureaucrats in the Song Dynasty were both scholars and literati,and therefore their works always revealed their academic skills.It is highly desirable when we study Song Fu’s comical creation from the perspective of intertex-tuality.Scholar-bureaucrats in the Song Dynasty also adopted positive attitude rather than repulsion to mundane trait.Wandering between elegance and vulgarity,Song Fu made humorous feature of comical literary technique prominent with enormous contrasts between solemnity and frivolity,elegant and mediocrity.Song Fu could observe objects through feelings,interpret feelings through reason,merge feelings and reason together and balance them well,thus transcending the comicality of objects,arou-sing imagination and striking a chord in the hearts of the readers after a relaxation from reading Song Fu.Scholar-bureaucrats in Song Dynasty had critical spirits of real politik and conscientious moralities to the manners and morals of the times.Song Fu inherited the emotion of saving society from comical literary technique,and carried it forward.%辞赋创作自娱娱人的内在冲动相当明显,宋赋对滑稽描写相当重视。宋代文化重视学殖深淳、理趣盎然和道德情怀,这三者构成了宋赋滑稽艺术的基本要素。宋代文人大多兼具学者与作家身份,其诗文创作相当重视彰显学术,因而从互文性的角度来观照宋赋的滑稽艺术,是非常有必要、有意义的。对于滑稽的世俗特色,宋人在辞赋创作中以提升的态度来面对,而非拒斥。游走于雅与俗之间的宋赋,在庄严与轻

  14. ORIS: the Oak Ridge Imaging System program listings. [Nuclear medicine imaging with rectilinear scanner and gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Bell, P. R.; Dougherty, J. M.

    1978-04-01

    The Oak Ridge Imaging System (ORIS) is a general purpose access, storage, processing and display system for nuclear medicine imaging with rectilinear scanner and gamma camera. This volume contains listings of the PDP-8/E version of ORIS Version 2. The system is designed to run under the Digital Equipment Corporation's OS/8 monitor in 16K or more words of core. System and image file mass storage is on RK8E disk; longer-time image file storage is provided on DECtape. Another version of this program exists for use with the RF08 disk, and a more limited version is for DECtape only. This latter version is intended for non-medical imaging.

  15. Revisiting the Rigidly Rotating Magnetosphere model for $\\sigma$ Ori E - II. Magnetic Doppler imaging, arbitrary field RRM, and light variability

    CERN Document Server

    Oksala, M E; Krticka, J; Townsend, R H D; Wade, G A; Prvak, M; Mikulasek, Z; Silvester, J; Owocki, S P

    2015-01-01

    The initial success of the Rigidly Rotating Magnetosphere (RRM) model application to the B2Vp star sigma OriE by Townsend, Owocki & Groote (2005) triggered a renewed era of observational monitoring of this archetypal object. We utilize high-resolution spectropolarimetry and the magnetic Doppler imaging (MDI) technique to simultaneously determine the magnetic configuration, which is predominately dipolar, with a polar strength Bd = 7.3-7.8 kG and a smaller non-axisymmetric quadrupolar contribution, as well as the surface distribution of abundance of He, Fe, C, and Si. We describe a revised RRM model that now accepts an arbitrary surface magnetic field configuration, with the field topology from the MDI models used as input. The resulting synthetic Ha emission and broadband photometric observations generally agree with observations, however, several features are poorly fit. To explore the possibility of a photospheric contribution to the observed photometric variability, the MDI abundance maps were used to ...

  16. Créativité mathématique Fondements de la théorie axiomatique des jeux dynamiques

    OpenAIRE

    Tomski, Grigori

    2004-01-01

    Le développement de la théorie des jeux différentiels, d’abord dans les systèmes décrits par les équations différentielles ordinaires puis dans les autres systèmes, a conduit au développement de l’approche axiomatique. G. Tomski a commencé ses recherches dans ce domaine à partir de 1972 et il est devenu vers 1980 le plus grand spécialiste de la théorie axiomatique des jeux dynamiques en URSS et, à notre avis, à l’échelle mondiale. Tomski a proposé plusieurs concepts et méthodes, originales et...

  17. Quelle théorie pour la gouvernance?De la gouvernance actionnariale à la gouvernance cognitive...

    OpenAIRE

    Gérard Charreaux

    2001-01-01

    Cet article a pour objectif de faire une synthèse des différentes théories de la gouvernance des entreprises. Les différents modèles de création et de répartition de la valeur qui sous-tendent les théories, sont présentés en première partie. La seconde partie permet de préciser les conséquences induites en matière de définition et d'explication des systèmes de gouvernance ainsi que d'éclairer un certain nombre de questions normatives du domaine telles que l'éventuelle supériorité de certains ...

  18. IS6110 in oriC affects the morphology and growth of Mycobacterium tuberculosis and attenuates virulence in mice.

    Science.gov (United States)

    Casart, Yveth; Turcios, Lilia; Florez, Ingrid; Jaspe, Rossana; Guerrero, Elba; de Waard, Jacobus; Aguilar, Diana; Hérnandez-Pando, Rogelio; Salazar, Leiria

    2008-11-01

    The IS6110 element is widely used in studies of molecular epidemiology of tuberculosis and it is considered the gold standard for genotyping Mycobacterium tuberculosis strains. Because of its high frequency of transposition, IS6110 is probably a major contributor to the evolution of M. tuberculosis. Nevertheless, very few studies of the effect of IS6110 insertions on the virulence of M. tuberculosis have been reported. We analysed two isogenic groups of M. tuberculosis strains isolated from the sputa of two patients. Strains belonging to the same isogenic group differed from one another by one IS6110-oriC hybridising band, but they showed identical spoligo and MIRU-VNTR profiles. Isogenic strains containing the IS6110 element in oriC exhibited a diminished growth rate and average dimensions of the bacilli were modified; moreover, they were less virulent in a mouse model.

  19. ori science education in Aotearoa New Zealand. He pūtea whakarawe: aspirations and realities

    Science.gov (United States)

    Wood, Anaru; Lewthwaite, Brian

    2008-09-01

    This article reports on the first two phases of a multiphase science education development project in predominantly Māori kura (school communities) in the central region of the North Island of Aotearoa New Zealand. The development project in its entirety employs an action research methodology and by so doing endeavors to support the improvement of science education delivery in accordance with school community aspirations. The full project (a) establishes the current situation in Year 1-8 science education in the communities; (b) identifies developmental aspirations for stakeholders within the communities and identifies potential contributors and constraints to these aspirations; (c) implements mechanisms for achieving identified aspirations; and finally; (d) evaluates the effectiveness of such mechanisms. In its focus on the first two phases, this article incorporates the analytical lenses of Kaupapa Māori Theory and Bronfenbrenner's bio-ecological model. It concludes by outlining some priorities to consider for science education development based on the outcomes of our preliminary discussions.

  20. 5 Fu/CF联合 HCFU治疗晚期大肠癌%5-Fluorouracil,Leucovorin and Carmofur Combination in Treatment for Advanced Large intestinal Cancer

    Institute of Scientific and Technical Information of China (English)

    司海运; 岳晓婷

    2001-01-01

    [目的 ]观察 5 Fu/CF联合口服卡莫氟 (HCFU)与单用 5 Fu/CF治疗晚期大肠癌的近期疗效 . [方法 ]对 1998年 10月~ 2001年 4月收治的 36例大肠癌随机分为两组 , 治疗组 : 5 Fu/CF联合口服 HCFU; 对照组为 5 Fu/CF. [结果 ]治疗组总有效率 55.5% , 对照组总有效率 27.7% . [结论 ]5 Fu/CF联合口服 HCFU治疗晚期大肠癌较单用 5 Fu/CF方案化疗为好 .

  1. ori patients' experiences and perspectives of chronic kidney disease: a New Zealand qualitative interview study

    Science.gov (United States)

    Walker, Rachael C; Walker, Shayne; Morton, Rachael L; Tong, Allison; Howard, Kirsten; Palmer, Suetonia C

    2017-01-01

    Objectives To explore and describe Māori (the indigenous people of New Zealand) patients' experiences and perspectives of chronic kidney disease (CKD), as these are largely unknown for indigenous groups with CKD. Design Face-to-face, semistructured interviews with purposive sampling and thematic analysis. Setting 3 dialysis centres in New Zealand (NZ), all of which offered all forms of dialysis modalities. Participants 13 Māori patients with CKD and who were either nearing the need for dialysis or had started dialysis within the previous 12 months. Results The Māori concepts of whakamā (disempowerment and embarrassment) and whakamana (sense of self-esteem and self-determination) provided an overarching framework for interpreting the themes identified: disempowered by delayed CKD diagnosis (resentment of late diagnosis; missed opportunities for preventive care; regret and self-blame); confronting the stigma of kidney disease (multigenerational trepidation; shame and embarrassment; fear and denial); developing and sustaining relationships to support treatment decision-making (importance of family/whānau; valuing peer support; building clinician–patient trust); and maintaining cultural identity (spiritual connection to land; and upholding inner strength/mana). Conclusions Māori patients with CKD experienced marginalisation within the NZ healthcare system due to delayed diagnosis, a focus on individuals rather than family, multigenerational fear of dialysis, and an awareness that clinicians are not aware of cultural considerations and values during decision-making. Prompt diagnosis to facilitate self-management and foster trust between patients and clinicians, involvement of family and peers in dialysis care, and acknowledging patient values could strengthen patient engagement and align decision-making with patient priorities. PMID:28104711

  2. ori patients' experiences and perspectives of chronic kidney disease: a New Zealand qualitative interview study.

    Science.gov (United States)

    Walker, Rachael C; Walker, Shayne; Morton, Rachael L; Tong, Allison; Howard, Kirsten; Palmer, Suetonia C

    2017-01-19

    To explore and describe Māori (the indigenous people of New Zealand) patients' experiences and perspectives of chronic kidney disease (CKD), as these are largely unknown for indigenous groups with CKD. Face-to-face, semistructured interviews with purposive sampling and thematic analysis. 3 dialysis centres in New Zealand (NZ), all of which offered all forms of dialysis modalities. 13 Māori patients with CKD and who were either nearing the need for dialysis or had started dialysis within the previous 12 months. The Māori concepts of whakamā (disempowerment and embarrassment) and whakamana (sense of self-esteem and self-determination) provided an overarching framework for interpreting the themes identified: disempowered by delayed CKD diagnosis (resentment of late diagnosis; missed opportunities for preventive care; regret and self-blame); confronting the stigma of kidney disease (multigenerational trepidation; shame and embarrassment; fear and denial); developing and sustaining relationships to support treatment decision-making (importance of family/whānau; valuing peer support; building clinician-patient trust); and maintaining cultural identity (spiritual connection to land; and upholding inner strength/mana). Māori patients with CKD experienced marginalisation within the NZ healthcare system due to delayed diagnosis, a focus on individuals rather than family, multigenerational fear of dialysis, and an awareness that clinicians are not aware of cultural considerations and values during decision-making. Prompt diagnosis to facilitate self-management and foster trust between patients and clinicians, involvement of family and peers in dialysis care, and acknowledging patient values could strengthen patient engagement and align decision-making with patient priorities. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  3. Two New Eclipsing Binaries: V1626 Ori (Brh V38) and GSC 0486-4828 (Brh V64)

    Science.gov (United States)

    Lloyd, C.; Frank, P.; Bernhard, K.; Moschner, W.; Quester, W.

    2002-11-01

    V1626 Ori is an EA with a period of 1.137793 days containing a mid F-type main-sequence primary and an oversized early K-type secondary, which may or may not fill its Roche lobe. GSC 0486-4828 has a period of 9.27850 days and contains two apparently unevolved main-sequence stars of spectral types late B and early A.

  4. Kung-Fu: synthesis of wheelchair sport and self-protection.

    Science.gov (United States)

    Madorsky, J G; Scanlon, J R; Smith, B

    1989-06-01

    As persons with disabilities enter the mainstream of society, and as the incidence of violent crime in society rises, disabled persons become victims of violent crime more frequently. It is vital for citizens with significant physical limitations to take precautionary steps for their own safety. Martial arts offer time-honored methods of self-protection for members of society who are physically disadvantaged. The case history of a young man with paraplegia is used to illustrate the potential of Kung-Fu as a sport and as a method of training for self-protection and survival.

  5. [Label-free monitoring 5-FU induced SW 620 cells apoptosis using FTIR microspectroscopy].

    Science.gov (United States)

    Liu, Dong; Sun, Xue-Jun; Zhang, Chao; He, Sai; Du, Jun-Kai; Huo, Xiong-Wei; Zheng, Jian-Bao; Zhang, Shi-Yun; Zhang, Yuan-Fuz; Xu, Yi-Zhuang; Wu, Jin-Guang

    2013-12-01

    The aim of the present study was to evaluate Fourier transform infrared spectroscopy (FTIR) monitoring of biochemical changes in apoptosis cells. Different concentrations of 5-fluorouracil (5-FU) treated colon cancer cell lines SW620 were used to determine the optimum concentration of 5-FU IC50 by means of MTT assay. Cell starvation and 5-Fu synergistic cell cycle arrest was in G1 and S phase. FTIR combined with flow cytometry was applied to analysis of SW 620 cells and SW620 cells treated with 5-FU for 12h, 24h (early apoptosis) and 48 h (late apoptosis) respectively. The peak position and the intensity of all bands were measured and comparison was made between the SW620 and apoptotic SW620 cells. Apoptosis cells have following characteristics compared with SW620 cells (1) The band at 1 740 cm-1 is an C=O stretching vibration. Changes in these bands can reflect lipid changes, and relative peak intensity ratio 11740/11460 significantly increased (p<0. 05), indicating that the relative contents of lipid in apoptosis cells increased. (2) The band at the 1 410 cm-1 peak represents that C-H stretching related was increased to amino acid residues and shifted to higher wave numbers compared to other groups. I1410o/I 460 at early and late death phase was significantly increased, which suggests that the relative contents of amino acid residues in apoptosis cells increased (p <0. 05). New vibrational bands at 1 120 cm-1 appeared at 24 h and increased at 48 h compared with other groups. The 1 120 cm-1 absorption band is mainly due to ser, serine and threonine C-O(H) stretching vibration, and I1120/I 1460 significantly increased (p<0. 05), indicating that the relative quantity of amino acid residues in apoptosis cells increased due to that DNA unwinds the double helix. (3) 1 240 cm-1 is mainly due to the asymmetric stretching modes of phosphodiester groups shifting to higher wave number, illustrating that nucleic acid conformation was changed in apoptosis cells. (4) The band

  6. Clinical outcomes of amniotic membrane loaded with5-FU PLGA nanoparticles in experimental trabeculectomy

    Institute of Scientific and Technical Information of China (English)

    Fang; Hu; Xiang-Yun; Zeng; Zhao-Lian; Xie; Lin-Lin; Liu; Liang; Huang

    2015-01-01

    AIM: To evaluate the effect of amniotic membrane loaded with 5-fluorouracil poly(lactic-co-glycolic acid)(PLGA) nanoparticles(5-FU-NPs) in the surgical outcomes of experimental trabeculectomy in rabbits.METHODS: Thirty-two New Zealand white rabbits were randomly categorized into four groups with 8 rabbits in each group. Group 1, the control group, performed traditional trabeculectomy without adjuvant treatment.While the experimental groups performed compound trabeculectomy with different implantations including amniotic membrane(group 2), 5-FU-NPs(group 3) and amniotic membrane loaded with 5-FU-NPs(group 4).Clinical evaluations including IOP measurement and filtration bleb analysis were performed in all groups postoperatively.RESULTS: There is no significant difference of mean IOP in all groups at first 7d after surgery. While at P14,mean IOPs of experimental group 2(9.8 ±2.1 mm Hg),groups 3(8.9 ±2.8 mm Hg) and group 4(7.6 ±2.3 mm Hg)were significantly reduced compared to control group(12.4 ±2.6 mm Hg; n =8, P <0.05). At P21, mean IOPs of groups 3(11.7±3.2 mm Hg) and group 4(9.9±1.6 mm Hg)were significantly decreased compare to control group(17.9±1.6 mm Hg) and group 2(16.6 ±2.8 mm Hg; n =8,P <0.05). At P28, mean IOPs of groups 3(13.8±3.3 mm Hg)and group 4(10.6 ±2.0 mm Hg) were also significantly reduced compare to control group(19.4±2.3 mm Hg) and group 2(18.5 ±2.4 mm Hg; n =8, P <0.05). Meanwhile mean IOP of group 4 is significantly decreased compared to group 3 at P28(n =8, P <0.05). Survival analysis of functional filtration blub in all groups revealed the longest survival time in group 4(24.9±5.1d) compared to that in group 3(20.6 ±4.3d), group 2(15.0 ±5.2d) and control group(10.1±5.7d).CONCLUSION: Amniotic membrane loaded with 5-FuNPs may function as an effective anti-scarring implant and provides improved long-term surgical outcomes for experimental trabeculectomy in rabbits.

  7. In vivo dynamics of EBNA1-oriP interaction during latent and lytic replication of Epstein-Barr virus.

    Science.gov (United States)

    Daikoku, Tohru; Kudoh, Ayumi; Fujita, Masatoshi; Sugaya, Yutaka; Isomura, Hiroki; Tsurumi, Tatsuya

    2004-12-24

    The Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is required for maintenance of the viral genome DNA during the latent phase of EBV replication but continues to be synthesized after the induction of viral productive replication. An EBV genome-wide chromatin immunoprecipitation assay revealed that EBNA1 constantly binds to oriP of the EBV genome during not only latent but also lytic infection. Although the total levels of EBNA1 proved constant throughout the latter, the levels of the oriP-bound form were increased as lytic infection proceeded. EBV productive DNA replication occurs at discrete sites in nuclei, called replication compartments, where viral replication proteins are clustered. Confocal laser microscopic analyses revealed that whereas EBNA1 was distributed broadly in nuclei as fine punctate dots during the latent phase of infection, the protein became redistributed to the viral replication compartments and localized as distinct spots within and/or nearby the compartments after the induction of lytic replication. Taking these findings into consideration, oriP regions of the EBV genome might be organized by EBNA1 into replication domains that may set up scaffolding for lytic replication and transcription.

  8. The ALMA Early Science view of FUor/EXor objects. I. Through the looking-glass of V2775 Ori

    CERN Document Server

    Zurlo, Alice; Williams, Jonathan P; Canovas, Hector; Perez, Sebastian; Hales, Antonio; Mužić, Koraljka; Principe, David A; Ruíz-Rodríguez, Dary; Tobin, John; Zhang, Yichen; Zhu, Zhaohuan; Casassus, Simon; Prieto, Jose L

    2016-01-01

    As part of an ALMA survey to study the origin of episodic accretion in young eruptive variables, we have observed the circumstellar environment of the star V2775 Ori. This object is a very young, pre-main sequence object which displays a large amplitude outburst characteristic of the FUor class. We present Cycle-2 band 6 observations of V2775 Ori with a continuum and CO (2-1) isotopologue resolution of 0.25\\as (103 au). We report the detection of a marginally resolved circumstellar disc in the ALMA continuum with an integrated flux of $106 \\pm 2$ mJy, characteristic radius of $\\sim$ 30 au, inclination of $14.0^{+7.8}_{-14.5}$ deg, and is oriented nearly face-on with respect to the plane of the sky. The \\co~emission is separated into distinct blue and red-shifted regions that appear to be rings or shells of expanding material from quasi-episodic outbursts. The system is oriented in such a way that the disc is seen through the outflow remnant of V2775 Ori, which has an axis along our line-of-sight. The $^{13}$C...

  9. How efficient are New Zealand's District Health Boards at producing life expectancy gains for Māori and Europeans?

    Science.gov (United States)

    Sandiford, Peter; Consuelo, David Juan José Vivas; Rouse, Paul

    2017-04-01

    Use data envelopment analysis (DEA) to measure the efficiency of New Zealand's District Health Boards (DHBs) at achieving gains in Māori and European life expectancy (LE). Using life tables for 2006 and 2013, a two-output DEA model established the production possibility frontier for Māori and European LE gain. Confidence limits were generated from a 10,000 replicate Monte Carlo simulation. Results support the use of LE change as an indicator of DHB efficiency. DHB mean income and education were related to initial LE but not to its rate of change. LE gains were unrelated to either the initial level of life expectancy or to the proportion of Māori in the population. DHB efficiency ranged from 79% to 100%. Efficiency was significantly correlated with DHB financial performance. Changes in LE did not depend on the social characteristics of the DHB. The statistically significant association between efficiency and financial performance supports its use as an indicator of managerial effectiveness. Implications for public health: Efficient health systems achieve better population health outcomes. DEA can be used to measure the relative efficiency of sub-national health authorities at achieving health gain and equity outcomes. © 2016 The Authors.

  10. New constraints on the membership of the T dwarf S Ori 70 in the sigma Orionis cluster

    CERN Document Server

    Osorio, M R Zapatero; Bihain, G; Martín, E L; Rebolo, R; Villo-Perez, I; Díaz-Sánchez, A; Pérez-Garrido, A; Caballero, J A; Henning, T; Mundt, R; Navascues, D Barrado y; Bailer-Jones, C A L

    2007-01-01

    (Abridged) The nature of S Ori 70, a faint mid-T type object found towards the direction of the young sigma Orionis cluster, is still under debate. We intend to disentangle whether it is a field brown dwarf or a 3-Myr old planetary-mass member of the cluster. We report on near-infrared JHK_s and mid-infrared [3.6] and [4.5] IRAC/Spitzer photometry recently obtained for S Ori 70. The new near-infrared images (taken 3.82 yr after the discovery data) have allowed us to derive a very small proper motion (11.0 +/- 5.9 mas/yr) for this object, which is consistent with the proper motion of the cluster within 1.5 sigma the astrometric uncertainty. The colors (H-K_s), (J-K_s) and K_s-[3.6] appear discrepant when compared to T4-T7 dwarfs in the field. This behavior could be ascribed to a low-gravity atmosphere or alternatively to an atmosphere with a metallicity significantly different than solar. Taking into account the small proper motion of S Ori 70 and its new near- and mid-infrared colors, a low-gravity atmosphere...

  11. Agrobacterium-mediated transformation of Australian rice varieties and promoter analysis of major pollen allergen gene, Ory s 1.

    Science.gov (United States)

    Azria, Diah; Bhalla, Prem L

    2011-09-01

    A simple protocol for Agrobacterium-mediated transformation of Australian rice using mature embryos is described. Transgenic plants of two commercial genotypes of Australian rice, Amaroo and Millin, were produced. Transgenic plants were obtained by applying selection pressure to callus and to the regenerated shoots. Exclusion of the selective agent (hygromycin) during plant regeneration was found to be critical for recovery of transgenic plants from these commercial varieties. Transgenic plants were produced after 3 months. The developed system was also used to study spatial and temporal expression of a rice pollen-specific gene, Ory s 1. Expression of pOry s 1::uidA in transgenic rice demonstrated GUS expression in mature pollen, hence indicating potential use of this promoter to direct pollen-specific gene expression. Further Ory s 1 5' deletion study indicated that the pollen-specificity element may reside within -405 bp to the start of the transcription, while the region upstream of -405 contained a cis-acting regulatory element(s) responsible for quantitative expression of this gene.

  12. On the 2015 outburst of the EXor variable star V1118 Ori

    CERN Document Server

    Giannini, T; Antoniucci, S; Arkharov, A A; Larionov, V M; Di Paola, A; Bisogni, S; Marchetti, A

    2016-01-01

    After a long-lasting period of quiescence of about a decade, the source V1118 Ori, one of the most representative members of the EXor variables, is now outbursting. Since the initial increase of the near-infrared flux of about 1 mag (JHK bands) registered on 2015 September 22, the source brightness has remained fairly stable. We estimate DeltaV about 3 mag with respect to the quiescence phase. An optical/near-IR low-resolution spectrum has been obtained with the Large Binocular Telescope instruments MODS and LUCI2, and compared with a spectrum of similar spectral resolution and sensitivity level taken during quiescence. Together with the enhancement of the continuum, the outburst spectrum presents a definitely higher number of emission lines, in particular HI recombination lines of the Balmer, Paschen, and Brackett series, along with bright permitted lines of several species, forbidden atomic lines, and CO ro-vibrational lines. Both mass accretion and mass loss rates have significantly increased (by to about ...

  13. DM Ori: A Young Star Occulted by a Disturbance in Its Protoplanetary Disk

    Science.gov (United States)

    Rodriguez, Joseph E.; Stassun, Keivan G.; Cargile, Phillip; Shappee, Benjamin J.; Siverd, Robert J.; Pepper, Joshua; Lund, Michael B.; Kochanek, Christopher S.; James, David; Kuhn, Rudolf B.; Beatty, Thomas G.; Gaudi, B. Scott; Weintraub, David A.; Stanek, Krzysztof Z.; Holoien, Thomas W.-S.; Prieto, Jose L.; Feldman, Daniel M.; Espaillat, Catherine C.

    2016-11-01

    In some planet formation theories, protoplanets grow gravitationally within a young star’s protoplanetary disk, a signature of which may be a localized disturbance in the disk’s radial and/or vertical structure. Using time-series photometric observations by the Kilodegree Extremely Little Telescope South project and the All-Sky Automated Survey for SuperNovae, combined with archival observations, we present the discovery of two extended dimming events of the young star, DM Ori. This young system faded by ∼1.5 mag from 2000 March to 2002 August and then again in 2013 January until 2014 September (depth ∼1.7 mag). We constrain the duration of the 2000–2002 dimming to be 6 au from the host star, moving at ∼14.6 km s‑1 and is ∼4.9 au in width. This localized structure may indicate a disturbance such as that which may be caused by a protoplanet early in its formation.

  14. La miraculeuse efficacité de la théorie quantique

    CERN Document Server

    Miné, Philippe

    2014-01-01

    Avec les théories de la relativité, la physique quantique est une de ces révolutions conceptuelles qui ont, au cours du XXe siècle, tout changé à notre compréhension de la nature. Si fascinantes que soient ses applications – laser, cryptographie, GPS, ordinateur, imagerie médicale –, la physique quantique fait cependant intervenir des paradoxes déroutants pour notre logique ordinaire. Pénétrer les arcanes du monde quantique, c’est donc aussi accepter d’utiliser le langage des équations, dont les auteurs donnent ici une approche accessible et graduée, n’excédant pas le niveau du premier cycle universitaire et n’oubliant jamais les vertus de l’approche historique. Se révèle ainsi l’univers fabuleux des particules élémentaires, des forces fondamentales de la nature, de la cosmologie et des énigmes de l’espace-temps, thèmes sur lesquels doit s’édifier toute réflexion moderne sur la nature et ses lois. Mais acquérir une certaine familiarité avec le monde quantique ne sig...

  15. HST/STIS Ultraviolet Spectroscopy of the Components of the Massive Triple Star delta Ori A

    CERN Document Server

    Richardson, Noel D; Gull, Theodore R; Lindler, Don J; Gies, Douglas R; Corcoran, Michael F; Chené, André-Nicolas

    2015-01-01

    The multiple star system of delta Orionis is one of the closest examples of a system containing a luminous O-type, bright giant star (component Aa1). It is often used as a spectral-type standard and has the highest observed X-ray flux of any hot-star binary. The main component Aa1 is orbited by two lower mass stars, faint Aa2 in a 5.7 day eclipsing binary, and Ab, an astrometric companion with an estimated period of 346 years. Generally the flux from all three stars is recorded in ground-based spectroscopy, and the spectral decomposition of the components has proved difficult. Here we present HST/STIS ultraviolet spectroscopy of delta Ori A that provides us with spatially separated spectra of Aa and Ab for the first time. We measured radial velocities for Aa1 and Ab in two observations made near the velocity extrema of Aa1. We show tentative evidence for the detection of the Aa2 component in cross-correlation functions of the observed and model spectra. We discuss the appearance of the UV spectra of Aa1 and A...

  16. The 'warrior gene' and the Mãori people: the responsibility of the geneticists.

    Science.gov (United States)

    Perbal, Laurence

    2013-09-01

    The 'gene of' is a teleosemantic expression that conveys a simplistic and linear relationship between a gene and a phenotype. Throughout the 20th century, geneticists studied these genes of traits. The studies were often polemical when they concerned human traits: the 'crime gene', 'poverty gene', 'IQ gene', 'gay gene' or 'gene of alcoholism'. Quite recently, a controversy occurred in 2006 in New Zealand that started with the claim that a 'warrior gene' exists in the Mãori community. This claim came from a geneticist working on the MAOA gene. This article is interested in the responsibility of that researcher regarding the origin of the controversy. Several errors were made: overestimation of results, abusive use of the 'gene of' kind of expression, poor communication with the media and a lack of scientific culture. The issues of the debate were not taken into account sufficiently, either from the political, social, ethical or even the genetic points of view. After more than 100 years of debates around 'genes of' all kinds (here, the 'warrior gene'), geneticists may not hide themselves behind the media when a controversy occurs. Responsibilities have to be assumed.

  17. HST/STIS ULTRAVIOLET SPECTROSCOPY OF THE COMPONENTS OF THE MASSIVE TRIPLE STAR δ ORI A

    Energy Technology Data Exchange (ETDEWEB)

    Richardson, Noel D.; Moffat, Anthony F. J. [Département de physique and Centre de Recherche en Astrophysique du Québec (CRAQ), Université de Montréal, C.P. 6128, Succ. Centre-Ville, Montréal, Québec, H3C 3J7 (Canada); Gull, Theodore R.; Lindler, Don J. [Astrophysics Science Division, NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Gies, Douglas R. [Center for High Angular Resolution Astronomy and Department of Physics and Astronomy, Georgia State University, P.O. Box 5060, Atlanta, GA 30302-5060 (United States); Corcoran, Michael F. [CRESST and X-ray Astrophysics Laboratory NASA/GSFC, Greenbelt, MD 20771 (United States); Chené, André-Nicolas, E-mail: richardson@astro.umontreal.ca, E-mail: moffat@astro.umontreal.ca, E-mail: theodore.r.gull@nasa.gov, E-mail: don.j.lindler@nasa.gov, E-mail: gies@chara.gsu.edu, E-mail: michael.f.corcoran@nasa.gov, E-mail: achene@gemini.edu [Gemini Observatory, Northern Operations Center, 670 North A’ohoku Place, Hilo, HI 96720 (United States)

    2015-07-20

    The multiple star system of δ Orionis is one of the closest examples of a system containing a luminous O-type, bright giant star (component Aa1). It is often used as a spectral-type standard and has the highest observed X-ray flux of any hot-star binary. The main component Aa1 is orbited by two lower mass stars, faint Aa2 in a 5.7 day eclipsing binary, and Ab, an astrometric companion with an estimated period of 346 years. Generally the flux from all three stars is recorded in ground-based spectroscopy, and the spectral decomposition of the components has proved difficult. Here we present Hubble Space Telescope/Space Telescope Imaging Spectrograph ultraviolet spectroscopy of δ Ori A that provides us with spatially separated spectra of Aa and Ab for the first time. We measured radial velocities for Aa1 and Ab in two observations made near the velocity extrema of Aa1. We show tentative evidence for the detection of the Aa2 component in cross-correlation functions of the observed and model spectra. We discuss the appearance of the UV spectra of Aa1 and Ab with reference to model spectra. Both stars have similar effective temperatures, but Ab is fainter and is a rapid rotator. The results will help in the interpretation of ground-based spectroscopy and in understanding the physical and evolutionary parameters of these massive stars.

  18. Settling Indigenous Claims to Protected Areas: Weighing Māori Aspirations Against Australian Experiences

    Directory of Open Access Journals (Sweden)

    Phil O′B. Lyver

    2014-01-01

    Full Text Available Efforts to resolve indigenous peoples′ grievances about the negative impacts of protected areas established on their customary estates by governments are driving the development of shared governance and management. The Tϋhoe people have sought that the settlement of their grievances against the New Zealand government include unencumbered rights to manage Te Urewera, guided by scientific and traditional knowledge and practices, for conservation and social benefits for the Tϋhoe people and the broader public. We led a study tour to allow Tϋhoe and other Mβori representatives to gain first-hand experience of long-standing jointly managed protected areas in Australia that the New Zealand government had drawn on in proposing mechanisms to resolve the Tϋhoe claim. We found that these areas were a poor fit to the study tour participants′ aspirations that indigenous world views would underpin governance and that indigenous people would be empowered. Our findings highlight that settlement must be transformational in terms of attitudes and relationships. Collaborative problem-solving processes that build trust can contribute. In areas like Te Urewera, where tenure boundaries fragment a landscape that is a coherent whole in indigenous world views, settlement processes can offer the prospect of landscape-scale outcomes for social justice and conservation.

  19. X-ray, UV and optical analysis of supergiants: $\\epsilon$ Ori

    CERN Document Server

    Puebla, Raul E; Zsargó, Janos; Cohen, David H; Leutenegger, Maurice A

    2015-01-01

    We present a multi-wavelength (X-ray to optical) analysis, based on non-local thermodynamic equilibrium photospheric+wind models, of the B0 Ia-supergiant: $\\epsilon$~Ori. The aim is to test the consistency of physical parameters, such as the mass-loss rate and CNO abundances, derived from different spectral bands. The derived mass-loss rate is $\\dot{M}/\\sqrt{f_\\infty}\\sim$1.6$\\times$10$^{-6}$ M$_\\odot$ yr$^{-1}$ where $f_\\infty$ is the volume filling factor. However, the S IV $\\lambda\\lambda$1062,1073 profiles are too strong in the models; to fit the observed profiles it is necessary to use $f_\\infty<$0.01. This value is a factor of 5 to 10 lower than inferred from other diagnostics, and implies $\\dot{M} \\lesssim1 \\times 10^{-7}$ M$_\\odot$ yr$^{-1}$. The discrepancy could be related to porosity-vorosity effects or a problem with the ionization of sulfur in the wind. To fit the UV profiles of N V and O VI it was necessary to include emission from an interclump medium with a density contrast ($\\rho_{cl}/\\rho...

  20. X-ray Emission and Corona of the Young Intermediate Mass Binary $\\theta^1$ Ori E

    CERN Document Server

    Huenemoerder, David P; Testa, Paola; Kesich, Anthony; Canizares, Claude R

    2009-01-01

    Theta 1 Ori E is a young, moderate mass binary system, a rarely observed case of spectral-type G-giants of about 3 Solar masses, which are still collapsing towards the main sequence. We have obtained high resolution X-ray spectra with Chandra and find that the system is very active and similar to coronal sources, having emission typical of magnetically confined plasma: a broad temperature distribution with a hot component and significant high energy continuum; narrow emission lines from H- and He-like ions, as well as a range of Fe ions, and relative luminosity, L_x/L_bol = 0.001. Density, while poorly constrained, is consistent with the low density limits as determined from Mg XI and Ne IX emission lines. Coronal elemental abundances are sub-Solar, with Ne being the highest at about 0.4 times Solar. We find a possible trend in Trapezium hot plasmas towards low relative abundances of Fe, O, and Ne, which is hard to explain in terms of the dust depletion scenarios of low-mass young stars. Variability was unusu...

  1. Magnetism and binarity of the Herbig Ae star V380 Ori

    CERN Document Server

    Alecian, E; Catala, C; Bagnulo, S; Böhm, T; Bouret, J -C; Donati, J -F; Folsom, C P; Grunhut, J; Landstreet, J D

    2009-01-01

    In this paper we report the results of high-resolution circular spectropolarimetric monitoring of the Herbig Ae star V380 Ori, in which we discovered a magnetic field in 2005. A careful study of the intensity spectrum reveals the presence of a cool spectroscopic companion. By modelling the binary spectrum we infer the effective temperature of both stars: $10500\\pm 500$ K for the primary, and $5500\\pm500$ K for the secondary, and we argue that the high metallicity ($[M/H] = 0.5$), required to fit the lines may imply that the primary is a chemically peculiar star. We observe that the radial velocity of the secondary's lines varies with time, while that of the the primary does not. By fitting these variations we derive the orbital parameters of the system. We find an orbital period of $104\\pm5$ d, and a mass ratio ($M_{\\rm P}/M_{\\rm S}$) larger than 2.9. The intensity spectrum is heavily contaminated with strong, broad and variable emission. A simple analysis of these lines reveals that a disk might surround the...

  2. DM Ori: A Young Star Occulted by a Disturbance in its Protoplanetary Disk

    CERN Document Server

    Rodriguez, Joseph E; Cargile, Phillip; Shappee, Benjamin J; Siverd, Robert J; Pepper, Joshua; Lund, Michael B; Kochanek, Christopher S; James, David; Kuhn, Rudolf B; Beatty, Thomas G; Gaudi, B Scott; Weintraub, David A; Stanek, Krzysztof Z; Holoien, Thomas W S; Prieto, Jose L; Feldman, Daniel M; Espaillat, Catherine C

    2016-01-01

    In some planet formation theories, protoplanets grow gravitationally within a young star's protoplanetary disk, a signature of which may be a localized disturbance in the disk's radial and/or vertical structure. Using time-series photometric observations by the Kilodegree Extremely Little Telescope South (KELT-South) project and the All-Sky Automated Survey for SuperNovae (ASAS-SN), combined with archival observations, we present the discovery of two extended dimming events of the young star, DM Ori. This young system faded by $\\sim$1.5 mag from 2000 March to 2002 August and then again in 2013 January until 2014 September (depth $\\sim$1.7 mag). We constrain the duration of the 2000-2002 dimming to be $$6 AU from the host star, moving at $\\sim$14.6 km/s, and is $\\sim$4.9 AU in width. This localized structure may indicate a disturbance such as may be caused by a protoplanet early in its formation.

  3. A Herschel view of protoplanetary disks in the $\\sigma$ Ori cluster

    CERN Document Server

    Maucó, Karina; Calvet, Nuria; Ballesteros-Paredes, Javier; Briceño, César; McClure, Melissa; D'Alessio, Paola; Anderson, Kassandra; Ali, Babar

    2016-01-01

    We present new Herschel PACS observations of 32 T Tauri stars in the young ($\\sim$3 Myr) $\\sigma$ Ori cluster. Most of our objects are K & M stars with large excesses at 24 $\\mu$m. We used irradiated accretion disk models of D'Alessio et al. (2006) to compare their spectral energy distributions with our observational data. We arrive at the following six conclusions. (i) The observed disks are consistent with irradiated accretion disks systems. (ii) Most of our objects (60%) can be explained by significant dust depletion from the upper disk layers. (iii) Similarly, 61% of our objects can be modeled with large disk sizes ($\\rm R_{\\rm d} \\geq$ 100 AU). (iv) The masses of our disks range between 0.03 to 39 $\\rm M_{Jup}$, where 35% of our objects have disk masses lower than 1 Jupiter. Although these are lower limits, high mass ($>$ 0.05 M$_{\\odot}$) disks, which are present e.g, in Taurus, are missing. (v) By assuming a uniform distribution of objects around the brightest stars at the center of the cluster, we...

  4. Long-term infrared variability of the UX Ori-type star SV Cep

    CERN Document Server

    Juhasz, A; Abraham, P; Dullemond, C P; Juhasz, Attila; Prusti, Timo; Abraham, Peter; Dullemond, Cornelis P.

    2006-01-01

    We investigate the long-term optical-infrared variability of SV Cep, and explain it in the context of an existing UX Ori (UXOR) model. A 25-month monitoring programme was completed with the Infrared Space Observatory in the 3.3-100 um wavelength range. Following a careful data reduction, the infrared light curves were correlated with the variations of SV Cep in the V-band. A remarkable correlation was found between the optical and the far-infrared light curves. In the mid-infrared regime the amplitude of variations is lower, with a hint for a weak anti-correlation with the optical changes. In order to interpret the observations, we modelled the spectral energy distribution of SV Cep assuming a self-shadowed disc with a puffed-up inner rim, using a 2-dimensional radiative transfer code. We found that modifying the height of the inner rim, the wavelength-dependence of the long-term optical-infrared variations is well reproduced, except the mid-infrared domain. The origin of variation of the rim height might be ...

  5. The pilin protein FimP from Actinomyces oris: crystal structure and sequence analyses.

    Directory of Open Access Journals (Sweden)

    Karina Persson

    Full Text Available The Actinomyces oris type-1 pili are important for the initial formation of dental plaque by binding to salivary proteins that adhere to the tooth surface. Here we present the X-ray structure of FimP, the protein that is polymerized into the type-1 pilus stalk, assisted by a pili-specific sortase. FimP consists of three tandem IgG-like domains. The middle and C-terminal domains contain one autocatalyzed intramolecular isopeptide bond each, a feature used by Gram-positive bacteria for stabilization of surface proteins. While the N-terminal domain harbours all the residues necessary for forming an isopeptide bond, no such bond is observed in the crystal structure of this unpolymerized form of FimP. The monomer is further stabilized by one disulfide bond each in the N- and C-terminal domains as well as by a metal-coordinated loop protruding from the C-terminal domain. A lysine, predicted to be crucial for FimP polymerization by covalent attachment to a threonine from another subunit, is located at the rim of a groove lined with conserved residues. The groove may function as a docking site for the sortase-FimP complex. We also present sequence analyses performed on the genes encoding FimP as well as the related FimA, obtained from clinical isolates.

  6. A Coordinated X-ray and Optical Campaign on the Nearest Massive Eclipsing Binary, Delta Ori Aa: I. Overview of the X-ray Spectrum

    CERN Document Server

    Corcoran, M F; Pablo, H; Shenar, T; Pollock, A M T; Waldron, W L; Moffat, A F J; Richardson, N D; Russell, C M P; Hamaguchi, K; Huenemoerder, D P; Oskinova, L; Hamann, W -R; Naze, Y; Ignace, R; Evans, N R; Lomax, J R; Hoffman, J L; Gayley, K; Owocki, S P; Leutenegger, M; Gull, T R; Hole, K T; Lauer, J; Iping, R C

    2015-01-01

    We present an overview of four phase-constrained Chandra HETGS X-ray observations of Delta Ori A. Delta Ori A is actually a triple system which includes the nearest massive eclipsing spectroscopic binary, Delta Ori Aa, the only such object which can be observed with little phase-smearing with the Chandra gratings. Since the fainter star, Delta Ori Aa2, has a much lower X-ray luminosity than the brighter primary, Delta Ori A provides a unique system with which to test the spatial distribution of the X-ray emitting gas around Delta Ori Aa1 via occultation by the photosphere of and wind cavity around the X-ray dark secondary. Here we discuss the X-ray spectrum and X-ray line profiles for the combined observation, having an exposure time of nearly 500 ksec and covering nearly the entire binary orbit. Companion papers discuss the X-ray variability seen in the Chandra spectra, present new space-based photometry and ground-based radial velocities simultaneous with the X-ray data to better constrain the system parame...

  7. Cancer in Māori: lessons from prostate, colorectal and gastric cancer and progress in hereditary stomach cancer in New Zealand.

    Science.gov (United States)

    Blair, Vanessa; Kahokehr, Arman; Sammour, Tarik

    2013-01-01

    Persisting ethnic disparities in cancer incidence and outcomes exist between Māori and non-Māori in Aotearoa/New Zealand. It is difficult to disentangle the complex interplay of environmental and genetic factors that contribute to the variation in cancer statistics between these two groups. In Māori, the sites of highest cancer incidence are the prostate in men, breast in women and lung in both - the next most common cancers in Māori are colorectal and stomach cancer. This paper discusses colorectal, prostate and stomach cancer in Māori to illustrate selected issues that impact on cancer care. Colorectal cancer is discussed to illustrate the importance of accurate cancer statistics to focus management strategies. Prostate cancer in Māori is reviewed - an area where cultural factors impact on care delivery. Sporadic stomach cancer in New Zealand is used to show how sub-classification of different types of cancer can be important and illustrate the breadth of putative causal factors. Then follows an overview of developments in hereditary gastric cancer in New Zealand in the last 15 years, showing how successful clinical and research partnerships can improve patient outcomes. One example is the Kimi Hauora Clinic, which provides support to cancer patients, mutation carriers and their families, helping them navigate the interface with the many health-care professionals involved in the multidisciplinary care of cancer patients in the 21st century.

  8. Moderate intensity static magnetic fields affect mitotic spindles and increase the antitumor efficacy of 5-FU and Taxol.

    Science.gov (United States)

    Luo, Yan; Ji, Xinmiao; Liu, Juanjuan; Li, Zhiyuan; Wang, Wenchao; Chen, Wei; Wang, Junfeng; Liu, Qingsong; Zhang, Xin

    2016-06-01

    Microtubules are the fundamental components in mitotic spindle, which plays essential roles in cell division. It was well known that purified microtubules could be affected by static magnetic fields (SMFs) in vitro because of the diamagnetic anisotropy of tubulin. However, whether these effects lead to cell division defects was unknown. Here we find that 1T SMFs induce abnormal mitotic spindles and increase mitotic index. Synchronization experiments show that SMFs delay cell exit from mitosis and cause mitotic arrest. These mimic the cellular effects of a microtubule-targeting drug Paclitaxel (Taxol), which is frequently used in combination with 5-Fluorouracil (5-FU) and Cisplatin in cancer treatment. Using four different human cancer cell lines, HeLa, HCT116, CNE-2Z and MCF7, we find that SMFs increase the antitumor efficacy of 5-FU or 5-FU/Taxol, but not Cisplatin, which indicates that the SMF-induced combinational effects with chemodrugs are drug-specific. Our study not only reveals the effect of SMFs on microtubules to cause abnormal mitotic spindles and delay cells exit from mitosis, but also implies the potential applications of SMFs in combination with chemotherapy drugs 5-FU or 5-FU/Taxol, but not with Cisplatin in cancer treatment.

  9. Impairment of energy metabolism in cardiomyocytes caused by 5-FU catabolites can be compensated by administration of amino acids.

    Science.gov (United States)

    Lischke, Julia; Lang, Christine; Sawodny, Oliver; Feuer, Ronny

    2015-01-01

    Identification of patients with increased risk of 5-fluorouracil (5-FU)-related toxicity is an important challenge for cancer treatment. Research often focus on dihydropyrimidine dehydrogenase (DPYD) deficiency in this context. However, patients with normal DPYD activity may also develop life-threatening 5-FU adverse effects. DPYD initiates the catabolic route of 5-FU generating metabolites such as fluoroacetate (FAC). The catabolite FAC is known to inhibit the TCA cycle enzyme aconitase, which is supposed to impair mitochondrial energy metabolism. Therefore, we aim for a systems understanding of the association of 5-FU-related cardiac side effects with aconitase inhibition caused by FAC. Using a mitochondrial model of cardiomyocytes we found strong depletion of ATP production and citrate accumulation as main effects of aconitase inhibition. Shadow price analysis revealed that the uptakes of valine, arginine, proline and glutamate are most effective in compensating the impairment of energy metabolism. Our findings suggest that 5-FU catabolism contributes to the occurrence of cardiac adverse effects and are the basis for further biomarker identifications and development of side effect treatment.

  10. Supra-additive antitumor activity of 5FU with tumor necrosis factor-related apoptosis-inducing ligand on gastric and colon cancers in vitro.

    Science.gov (United States)

    Shimoyama, Shouji; Mochizuki, Yoshino; Kusada, Osamu; Kaminishi, Michio

    2002-09-01

    We investigated supra-additive cytotoxic effects of 5-fluorouracil (5FU) on gastric and colon cancer cells with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in vitro. p53 wild- and mutant-type gastric and colon cancer cell lines were treated by 5FU alone, TRAIL alone, and a combination of 5FU and TRAIL, and cell viability after each treatment was determined by MTT assay. The p53 wild-type cells were more sensitive to 5FU alone or to TRAIL alone than p53 mutant-type cells. The cell growth inhibitory effects of the combined treatment were supra-additive and more significant in proportion to the increasing concentrations of TRAIL as compared with 5FU alone both in p53 wild- and mutant-type cells. Furthermore, TRAIL could cause a decrease in 5FU IC(50) to within the range of clinically relevant doses, particularly in p53 wild-type cells. This is the first demonstration of the supra-additive antitumor activity of 5FU with TRAIL on gastric cancer cells, giving evidence that TRAIL can reduce the requirement for 5FU that ultimately results in minimizing risks for systemic side effects while increasing the antitumor activity of 5FU, suggesting the clinical applicability of this combination for gastric and colon cancers.

  11. "La reproduction des eaux par les arrosages", historique et actualité d'une théorie

    Directory of Open Access Journals (Sweden)

    Jeanne Riaux

    2007-11-01

    Full Text Available Au milieu du XIXe siècle, la "théorie de reproduction des eaux par les arrosages" découverte par M. Félips a déchaîné des passions, des Pyrénées catalanes jusqu'à la Société Royale et Centrale d'agriculture de Paris. Cette théorie, fondée sur de sérieux et répétés calculs de débit jusqu'en 1841, prouve que les arrosages effectués en amont permettent d'augmenter la quantité d'eau disponible en aval. Les arguments présentés furent d'abord tenus pour saugrenus : est-il imaginable que les arrosages produisent de l'eau plutôt que de la consommer ? Plusieurs commissions d'ingénieurs ont été chargées de vérifier cette étonnante théorie en 1846. Le résultat fut sans appel : il y avait bien plus d'eau à l'aval qu'à l'amont de la vallée considérée. La théorie de Monsieur Félips a été primée en 1849, puis est tombée dans l'oubli. Au-delà de son aspect anecdotique, ce qui nous semble devoir être souligné, c'est l'étrange résonance que cette théorie présente avec les arguments aujourd'hui présentés par les défenseurs de l'irrigation gravitaire "traditionnelle", telle qu'elle est pratiquée dans les Pyrénées-Orientales. Entre 2001 et 2003, des études ont été effectuées, visant à démontrer que ce mode d'irrigation, souvent considéré comme "gaspillant" de l'eau est en fait bénéfique : l'irrigation gravitaire permet de recharger les nappes d'eau souterraines. N'y a-t-il pas, à l'heure d'une double remise en cause de l'irrigation gravitaire (gaspillage et anachronisme, une certaine ironie à redécouvrir cette théorie… pas si désuète en somme ?

  12. Processes of economic restructuring and functional transformations of an industrial city based on the city of Żory, Poland

    Directory of Open Access Journals (Sweden)

    Magda-Żabińska Krystyna

    2014-03-01

    Full Text Available For decades the Silesian voivodeship has played a key role in the development of the economy of Poland. Its central area is occupied by an old industrial region which has been developed since the 19th century on the basis of coal mining and the processing of iron, zinc and lead ores. As a result of the political transformation of the country, after 1989, the region was faced with a difficult economic situation – a significant reduction in production was recorded and numerous unprofitable obsolete mines and steelworks were decommissioned. Since then, the economy of the Silesian region has been subject to restructuring and revitalization. This article presents this process as illustrated by a representative city – Żory. This is one of the oldest cities in the region which was established in the Middle Ages (1272. For centuries, its inhabitants were engaged in agriculture, fish breeding and trade. Its industrial development started with the construction of the ironworks at the beginning of the 19th century, but the investments after the Second World War were of greatest importance to the city. At that time the “Fadom” factory, two hard coal mines – “Żory” and “Krupiński” – and a plant known as Zakład Tworzyw Sztucznych ERG (Synthetic Fibres Works “ERG” were constructed. After the political and economic changes of 1989 the economy of the city required urgent restructuring. The change of the function of the city of Żory proceeded gradually, but the creation of economic areas and zones, especially the establishment of the Jastrzębie Zdrój and Żory Subzone of the Katowice Special Economic Zone (1996 and Żory Industrial Park (2004, were of crucial importance to the development of the city. Over the past 20 years the city of Żory has changed from a city dependent on the extractive industries, without signs of a developed urban infrastructure, to a centre of a varied structure of production. Employment in industry and

  13. [Clinical effects of Fu Fang Ya Tong Ding on gingivitis and pericoronitis].

    Science.gov (United States)

    Wan, Hu-Chun; Zhang, Shuang; Wu, Ni-Ya; Kang, Dong; Hu, Li-Jie; Wang, Li-Zhi; Zhang, Ji-Ying; Xie, Ping

    2008-04-01

    To evaluate the clinical effects of Fu Fang Ya Tong Ding on treatment of gingivitis and pericoronitis. 120 clinical patients with gingivitis or pericoronitis were randomly divided into 3 groups (40 patients in each group). After routine rinse treatment for all patients, patients in the test group were treated with Fu Fang Ya Tong Ding, patients in the positive group were treated with iodine glycerol, while that time patients in the negative group received no treatment anymore. Ten minutes after treatment, visual analogue scale (VAS) was used to record the severity of pain for each patient. 3 days and 7 days later, pain and inflammation degree were also recorded by pain three-degree scoring method and index of gingivitis. The total treatment effects were evaluated under a comprehensive clinical treatment standard. 10 minutes after treatment, 40.0% of patients in the test group had almost no pain, while no obvious reduction of pain was found in the control group. 3 days, 7 days after the treatment, 92.5%, 95.0% of patients in the test group had no pain, and 55.0%, 90.0% of patients in the positive group had no pain. In the negative group, there were 47.5% of patients which pain was still remained in 7 days. 7 days after treatment, gingival index in the test group reduced by 25.0% and 42.8% compared with the positive and negative groups (Ppericoronitis through significantly reducing inflammation and pain.

  14. Evidence for an FU Orionis Outburst from a Classical T Tauri Star

    CERN Document Server

    Miller, Adam A; Covey, Kevin R; Poznanski, Dovi; Silverman, Jeffrey M; Kleiser, Io K W; Rojas-Ayala, Barbara; Muirhead, Philip S; Cenko, S Bradley; Bloom, Joshua S; Kasliwal, Mansi M; Filippenko, Alexei V; Law, Nicholas M; Ofek, Eran O; Dekany, Richard G; Rahmer, Gustavo; Hale, David; Smith, Roger; Quimby, Robert M; Nugent, Peter; Jacobsen, Janet; Zolkower, Jeff; Velur, Viswa; Walters, Richard; Henning, John; Bui, Khanh; McKenna, Dan; Kulkarni, Shrinivas R; Klein, Christopher R

    2010-01-01

    We present pre- and post-outburst observations of the new FU Orionis-like young stellar object Lk Halpha 188-G4 (also known as HBC 722 and PTF 10qpf). Prior to this outburst, Lk Halpha 188-G4 would have been classified as a classical T Tauri star on the basis of its optical emission-line spectrum superposed on a K8-type photosphere, and photometric variability. The mid-infrared spectral index of Lk Halpha 188-G4 indicates a Class II type object. Lk Halpha 188-G4 exhibited a steady rise by ~1 mag over ~11 months starting in Aug. 2009, before a subsequent more abrupt rise of >3 mag on a time scale of ~2 months. Observations taken during and after eruption exhibit all of the defining characteristics of FU Orionis variables: (i) Lk Halpha 188-G4 increased in brightness by >4 mag, (ii) a bright optical/near-infrared reflection nebula has now appeared (iii) optical spectra in the outburst phase are consistent with a G supergiant and dominated by absorption lines, the only exception being Halpha which is characteriz...

  15. SN 2011fu: A type IIb Supernova with a luminous double-peaked light curve

    CERN Document Server

    Morales-Garoffolo, A; Bersten, M; Jerkstrand, A; Taubenberger, S; Benetti, S; Cappellaro, E; Kotak, R; Pastorello, A; Bufano, F; Domínguez, R M; Ergon, M; Fraser, M; Gao, X; García, E; Howell, D A; Isern, J; Smartt, S J; Tomasella, L; Valenti, S

    2015-01-01

    We present optical and near infrared observations of the type IIb supernova (SN) 2011fu from a few days to $\\sim300$ d after explosion. The SN presents a double-peaked light curve (LC) similar to that of SN 1993J, although more luminous and with a longer cooling phase after the primary peak. The spectral evolution is also similar to SN 1993J's, with hydrogen dominating the spectra to $\\sim40$ d, then helium gaining strength, and nebular emission lines appearing from $\\sim60$ d post-explosion. The velocities derived from the P-Cygni absorptions are overall similar to those of other type IIb SNe. We have found a strong similarity between the oxygen and magnesium line profiles at late times, which suggests that these lines are forming at the same location within the ejecta. The hydrodynamical modelling of the pseudo-bolometric LC and the observed photospheric velocities suggest that SN 2011fu was the explosion of an extended star ($\\rm R\\sim450$ R$_\\odot$), in which 1.3 $\\times 10^{51}$ erg of kinetic energy wer...

  16. Laser sclerectomy and 5-FU controlled-drug-release biodegradable implant for glaucoma therapy

    Science.gov (United States)

    Villain, Franck L.; Parel, Jean-Marie A.; Kiss, Katalin; Parrish, Richard K.; Kuhne, Francois; Takesue, Yoshiko; Hostyn, Patrick

    1993-06-01

    Laser sclerectomy, a simple filtering procedure performed to alleviate high intraocular pressure in glaucoma patients, was taught to offer longer lasting effect and therefore improve the patient's outcome when compared with the standard trabeculectomy procedure. Recent clinical trials have shown that this was not the case and pharmacologic wound healing modulation is also required with this new procedure. Five-Fluorouracil (5-FU) is useful as an adjunct treatment for glaucoma filtering surgery. However, efficacy depends upon maintaining sustained drug levels, currently achieved by repeated daily injection of the drug for several weeks. To overcome this limitation, we designed a biodegradable implant for the sustained release of 5-FU. After laser sclerectomy, the implant is inserted through the same 1 mm wide conjunctival snip incision and positioned below the open channel. Implantation takes less than a minute. The implant releases the drug for over 15 days and totally biodegrades in less than 100 days. The combined laser surgery and implantation procedure show great potentials for the treatment of glaucoma.

  17. Concurrent chemoradiotherapy with daily low dose CDDP/5FU for locally unresectable head and neck cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kohno, Naoyuki; Kitahara, Satoshi; Tamura, Etsuyo; Tanabe, Tetsuya [Kyorin Univ., Mitaka, Tokyo (Japan). School of Medicine; Murata, Yasuhiro [National Defence Medical Coll., Tokorozawa, Saitama (Japan)

    2002-07-01

    To improve the local control rate and the prognosis of locally unresectable head and neck cancer patients, we studied the concurrent chemoradiotherapy. Between September 1996 and September 2000, thirty-eight patients with locally unresectable head and neck cancer were administered concurrent chemoradiotherapy consisting of low-dose and long-term treatment with cisplatin (CDDP) plus 5-fluorouracil (5FU), or (L-CF); the L-CF regimen consisted of CDDP, 3 mg/m{sup 2} on 5 days of the week and 5FU, 150 mg/m{sup 2} as a 24-hour infusion on 5 days of the week. Concurrently, conventional radiotherapy was given up to total dose of around 60 Gy. In the 36 patients evaluable for response, 19 complete and 10 partial responses were noted, with an overall response rate of 81%. Oral mucositis and myelosuppression were the major side effects and dose limiting toxicity. This study demonstrates increase in survival among the responders (complete+partial) in the concurrent chemoradiotherapy setting. We concluded that this treatment strategy was beneficial. Further studies for patients with locally unresectable head and neck cancer are warranted. (author)

  18. Dosimetric study of photobiomodulation therapy in 5-FU-induced oral mucositis in hamsters

    Science.gov (United States)

    Cotomacio, Claudia Carrara; Campos, Luana; Nesadal de Souza, Douglas; Arana-Chavez, Victor Elias; Simões, Alyne

    2017-01-01

    Oral mucositis (OM) is a debilitating consequence of cancer treatment that could be treated with photobiomodulation therapy (PBMT); however, there is no consensus about its dosimetric parameters for OM healing. The aim of this study was to compare different PBMT protocols on OM treatment, through clinical and histological analysis. Thirty hamsters were used, in an induced model of OM by 5-fluorouracil (5-FU) and superficial scratching, in seven days of follow-up. The animals were divided into five groups: control (C), which received only anesthesia and chemotherapeutic vehicle; chemotherapy (Ch), which received anesthesia, 5-FU, and scratches; laser 1 (L1), the same as Ch group, PBMT 6 J/cm2 and 0.24 J (one point); laser 2 (L2), the same as Ch group, PBMT 25 J/cm2 and 1 J (one point); and laser 3 (L3), the same as Ch group, PBMT 4 points of 0.24 J and 6 J/cm2 each. The laser used has λ=660 nm, 0.04 cm2 of spot area, and 40 mW. The best PBMT protocol to maintain lowest OM levels compared to Ch group was L1, followed by L2 and L3. Our results suggest that the application mode of PBMT and the energy delivered per area could interfere with the OM healing.

  19. MTHFR polymorphisms and 5-FU-based adjuvant chemotherapy in colorectal cancer

    DEFF Research Database (Denmark)

    Afzal, Shoaib; Jensen, S; Vainer, B

    2009-01-01

    >T and 1298A>C polymorphisms were not associated with survival or relapse-free survival (P > 0.2). The 677 CC genotype was associated to toxicity (odds ratio = 1.83, P = 0.01). Conclusions: The MTHFR 677C>T and 1298A>C polymorphisms probably do not predict efficacy of adjuvant 5-FU treatment in colorectal......Methylenetetrahydrofolate reductase is a pivotal enzyme in folate metabolism and 5-fluorouracil (5-FU) cytotoxicity. Two common single-nucleotide polymorphisms (SNPs), MTHFR 677C>T (rs1801133) and 1298A>C (rs1801131), reduce enzyme activity. Initially, these SNPs were claimed to predict clinical....../leucovorin chemotherapy after intended curative resection between 1997 and 2003. Clinical data, including relapse rates, overall survival, and tumor stage, were collected. DNA was extracted from formalin-fixed tumor tissue and analyzed for the MTHFR 677C>T and 1298A>C SNPs with real-time PCR. Results: The MTHFR 677C...

  20. Inoperable esophageal carcinoma managed by combined chemotherapy (CBDCA, 5FU and VDS) and radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Morishima, Yuichi; Tashiro, Tsuguhiko; Yamamori, Hideo [Chiba Univ. (Japan). School of Medicine] [and others

    1997-06-01

    Eleven inoperable patients with advanced esophageal carcinoma were treated with chemotherapy (carboplatin, 5-FU, vindesine) and concomitant radiotherapy. Two patients (T2) received this treatment due to their poor general condition and refusal of operation, and 9 patients for infiltration of tumor into the adjacent organs (T4). Administration of carboplatin (30 mg/body) and 5-FU (250 mg/body) together with radiotherapy (1.8 Gy/d) for 5 days a week was performed. This chemoradiation therapy was carried out for 5 consecutive weeks. In addition, vindesine (1-3 mg/body) was administered in the 1st and 4th week. After evaluation, endoscopic balloon dilatation was performed in 6 patients with stenosis of the esophagus. The general response rate was 80%. CR was noted in 2 patients of T2 but 1 patient of T4 developed severe leucopenia and immunosuppression, and died of septic MOF. All but the MOF case could take enough food orally following the endoscopic dilatation. The 1-year survival rate in the T4 group (45%) was significantly better than the non-treatment group (0%). In conclusion, this treatment is beneficial for patients with inoperable esophageal carcinoma to obtain a satisfactory QOL and survival rate. (author)

  1. CDDP-5Fu-PYM化疗方案用于舌鳞癌的综合治疗

    Institute of Scientific and Technical Information of China (English)

    王贺伟; 任玉英; 苏平; 杜申钊; 许云

    2000-01-01

    目的:对于34例舌部鳞癌病人使用CDDP-5Fu-PYM化疗方案作为手术或放疗前的诱导化疗.方法:CDDP 80mg/m2,5Fu 3.0g,PYM 40mg在5天内按顺序给予.结果:7例原发灶消失,21例原发灶缩小50%以上,总有效率82.4%.结论:CD-DP-5Fu-PYM联合使用可以产生更加积极的抗肿瘤作用,取得满意的临床效果,为进一步治疗提供了良好的基础,有明显的优点和实用性.

  2. Whakawhanaungatanga: the importance of culturally meaningful connections to improve uptake of pulmonary rehabilitation by Māori with COPD – a qualitative study

    Directory of Open Access Journals (Sweden)

    Levack WMM

    2016-03-01

    Full Text Available William MM Levack, Bernadette Jones, Rebecca Grainger, Pauline Boland, Melanie Brown, Tristram R Ingham Department of Medicine, University of Otago, Wellington, New Zealand Background: Pulmonary rehabilitation is known to improve function and quality of life for people with chronic obstructive pulmonary disease (COPD. However, little research has been conducted on the influence of culture on experiences of pulmonary rehabilitation. This study examined factors influencing uptake of pulmonary rehabilitation by Māori with COPD in New Zealand. Method: Grounded theory nested within kaupapa Māori methodology. Transcripts were analyzed from interviews and focus groups with 15 Māori and ten New Zealand non-Māori invited to attend pulmonary rehabilitation for COPD. Māori participants had either attended a mainstream hospital-based program, a community-based program designed “by Māori, for Māori”, or had experienced both. Results: Several factors influencing uptake of pulmonary rehabilitation were common to all participants regardless of ethnicity: 1 participants’ past experiences (eg, of exercise; of health care systems, 2 attitudes and expectations, 3 access issues (eg, time, transport, and conflicting responsibilities, and 4 initial program experiences. These factors were moderated by the involvement of family and peers, interactions with health professionals, the way information on programs was presented, and by new illness events. For Māori, however, several additional factors were also identified relating to cultural experiences of pulmonary rehabilitation. In particular, Māori participants placed high value on whakawhanaungatanga: the making of culturally meaningful connections with others. Culturally appropriate communication and relationship building was deemed so important by some Māori participants that when it was absent, they felt strongly discouraged to attend pulmonary rehabilitation. Only the more holistic services

  3. Overcoming acquired drug resistance in colorectal cancer cells by targeted delivery of 5-FU with EGF grafted hollow mesoporous silica nanoparticles

    Science.gov (United States)

    Chen, Lijue; She, Xiaodong; Wang, Tao; He, Li; Shigdar, Sarah; Duan, Wei; Kong, Lingxue

    2015-08-01

    Acquired drug resistance (ADR) can be developed in colorectal cancer cells after 5-fluorouracil (5-FU) treatment and diminish the effectiveness of chemotherapy. In this work, acquired 5-FU resistance in the colorectal cancer cell line SW480 was obtained with the up-regulation of dihydropyrimidine dehydrogenase (DPYD) gene expression which can convert 5-FU to its inactive metabolite. To overcome ADR in colorectal cancer, hollow mesoporous silica nanoparticles (HMSNs) grafted with epidermal growth factor (EGF) were used as nanocarriers to deliver 5-FU to colorectal cancer cells with acquired drug resistance. The effect and mechanism of 5-FU loaded EGF grafted HMSNs (EGF-HMSNs-5-FU) in overcoming acquired drug resistance in SW480/ADR cells were studied. The EGF-HMSNs were demonstrated to be specifically internalized in EGFR overexpressed SW480/ADR cells via a receptor-mediated endocytosis and can escape from endo-lysosomes. The EGF-HMSNs-5-FU exhibited much higher cytotoxicity on SW480/ADR cells than HMSNs-5-FU and free 5-FU while the plain HMSNs did not show significant cytotoxicity. The mechanism of EGF-HMSNs-5-FU in overcoming drug resistance in SW480/ADR cells could be attributed to the specific internalization of EGF-HMSNs-5-FU in EGFR overexpressed cells which can lead to high intracellular drug accumulation and cause cell death through S phase arrest.Acquired drug resistance (ADR) can be developed in colorectal cancer cells after 5-fluorouracil (5-FU) treatment and diminish the effectiveness of chemotherapy. In this work, acquired 5-FU resistance in the colorectal cancer cell line SW480 was obtained with the up-regulation of dihydropyrimidine dehydrogenase (DPYD) gene expression which can convert 5-FU to its inactive metabolite. To overcome ADR in colorectal cancer, hollow mesoporous silica nanoparticles (HMSNs) grafted with epidermal growth factor (EGF) were used as nanocarriers to deliver 5-FU to colorectal cancer cells with acquired drug resistance. The

  4. Potentially functional SNPs (pfSNPs as novel genomic predictors of 5-FU response in metastatic colorectal cancer patients.

    Directory of Open Access Journals (Sweden)

    Jingbo Wang

    Full Text Available 5-Fluorouracil (5-FU and its pro-drug Capecitabine have been widely used in treating colorectal cancer. However, not all patients will respond to the drug, hence there is a need to develop reliable early predictive biomarkers for 5-FU response. Here, we report a novel potentially functional Single Nucleotide Polymorphism (pfSNP approach to identify SNPs that may serve as predictive biomarkers of response to 5-FU in Chinese metastatic colorectal cancer (CRC patients. 1547 pfSNPs and one variable number tandem repeat (VNTR in 139 genes in 5-FU drug (both PK and PD pathway and colorectal cancer disease pathways were examined in 2 groups of CRC patients. Shrinkage of liver metastasis measured by RECIST criteria was used as the clinical end point. Four non-responder-specific pfSNPs were found to account for 37.5% of all non-responders (P<0.0003. Five additional pfSNPs were identified from a multivariate model (AUC under ROC = 0.875 that was applied for all other pfSNPs, excluding the non-responder-specific pfSNPs. These pfSNPs, which can differentiate the other non-responders from responders, mainly reside in tumor suppressor genes or genes implicated in colorectal cancer risk. Hence, a total of 9 novel SNPs with potential functional significance may be able to distinguish non-responders from responders to 5-FU. These pfSNPs may be useful biomarkers for predicting response to 5-FU.

  5. High response rates following paclitaxel/5-FU and simultaneous radiotherapy in advanced head and neck carcinoma; Hohe Remissionsraten unter simultaner Radio- und Chemotherapie mit Paclitaxel/5-FU in der Behandlung fortgeschrittener Kopf-Hals-Tumoren

    Energy Technology Data Exchange (ETDEWEB)

    Schroeder, M.; Westerhausen, M. [St.-Johannes-Hospital, Duisburg (Germany). Medizinische Klinik II; Makoski, H.B. [Staedtische Kliniken, Duisburg (Germany). Radioonkologie; Sesterhenn, K. [St. Anna-Krankenhaus, Duisburg (Germany). HNO-Klinik; Schroeder, R. [Bristol Myers Squibb, Muenchen (Germany). Dept. of Oncology

    1997-11-01

    The main stay of treatment for head and neck cancer patients with advanced disease has been chemotherapy with Cisplatin/5-FU and simultaneous applied radiotherapy. With this multimodality treatment including radical surgery after two cycles of neoadjuvant chemotherapy and 40 Gy radiotherapy we reported 60% complete remission after 5 years for patients with stage III/IV of head and neck cancer. Paclitaxel, a new plant product, has demonstrated significant antineoplastic activity in head and neck tumors (ECOG-Study: 40% RR). Therefore we performed a trial with Taxol/5-FU and simultaneous radiation in a neoadjuvant and postoperative adjuvant setting of stage III/IV squamous cell carcinoma of the head and neck with pre-existent contraindication against Cisplatin. Patients and Methods: 30 patients with a primarily inoperable stage III/IV of SCC of the head and neck were enrolled to receive day 1 and 29 Taxol 175 mg/m{sup 2} as a 3-hour-infusion, followed by 120-hour-cvi of 1000 mg/m{sup 2}/d 5-FU. Locally irradiation was given ad 40 Gy (2 Gy/d/day 1-26). Radical surgery followed about day 56. Postoperatively patients received again 2 cycles of Taxol/5-FU and simultaneous irradiation with 30 Gy. Results: So far 30 patients were treated and all patients reached a CR after complete treatment, ongoing for 23/30 patients for 6 till 34 months: 4 patients developed a second neoplasia, and 3 patients gloved a local relapse. The principal toxicity was moderate (neutropenia, peripheral neuropathy, arthralgia/myalgia) and sensible with supportive care (e.g. PEG). Conclusions: The results suggest that the treatment of SCC of the head and neck with Taxol/5-FU and simultaneous radiation and radical surgery is a highly effective schedule and comparable with the treatment with Cisplatin/5-FU. (orig.) [Deutsch] Der Standard in der Behandlung weit forgeschrittener, primaer inoperabler Kopf-Hals-Tumoren stellte die Cisplatinhaltige Chemotherapiekombination mit 5-FU dar mit simultan

  6. Comparison of force, power, and striking efficiency for a Kung Fu strike performed by novice and experienced practitioners: preliminary analysis.

    Science.gov (United States)

    Neto, Osmar Pinto; Magini, Marcio; Saba, Marcelo M F; Pacheco, Marcos Tadeu Tavares

    2008-02-01

    This paper presents a comparison of force, power, and efficiency values calculated from Kung Fu Yau-Man palm strikes, when performed by 7 experienced and 6 novice men. They performed 5 palm strikes to a freestanding basketball, recorded by high-speed camera at 1000 Hz. Nonparametric comparisons and correlations showed experienced practitioners presented larger values of mean muscle force, mean impact force, mean muscle power, mean impact power, and mean striking efficiency, as is noted in evidence obtained for other martial arts. Also, an interesting result was that for experienced Kung Fu practitioners, muscle power was linearly correlated with impact power (p = .98) but not for the novice practitioners (p = .46).

  7. Clinical research on disciplinarian and character of treatment of zang-fu in syndrome differentiation on insomnia

    Institute of Scientific and Technical Information of China (English)

    凌丽; 薛金伟; 东贵荣

    2005-01-01

    Objective To investigate the therapeutic effect of insomnia with zang-fu in syndrome differentiation. Methods Seventy patients with insomnia according to the diagnostic sequence were randomly divided into two groups, the treatment group and the control group. Two groups received the therapeutic methods of acupuncture in syndrome differentiation and general acupuncture separately. After two courses of treatment and one month's follow-up, therapeutic effect was evaluated through statistical analysis. Resulds The therapeutic effects of the treatment group and the control group have significant differences which have statistical significance. Conclusion Zang-fu in syndrome differentiation may enhance the clinical therapeutic effect of insomnia.

  8. Hobbes, la coopération et la théorie des jeux

    Directory of Open Access Journals (Sweden)

    Marc Parmentier

    2010-04-01

    Full Text Available L'objectif de cet article est d'établir dans quelle mesure la théorie des jeux permet de formaliser et d'éclairer trois problématiques-clés de la philosophie politique de Hobbes : la guerre de tous contre tous dans l'état de nature ; le pacte instaurant un souverain absolu ; le mode d'action de ce dernier pour faire respecter les contrats au sein de l'état civil. L'analyse révèle qu'à certains égards le « problème de confiance » formulé par Amartya Sen apparaît plus pertinent que le célèbre « dilemme du prisonnier » évoqué par de nombreux commentateurs. Elle révèle également les ambiguïtés d'une œuvre susceptible de plusieurs modélisations et de plusieurs jugements possibles quant à la place de son auteur dans l'histoire du libéralisme.This article aims to establish whether the theory of games can formalise and explain three basic issues raised by Hobbes: the war of all against all in the state of nature; the social contract that establish absolute sovereignty; legitimate means at the sovereign’s disposal to impose people’s consent to abide by the rules of the social contract. It will be argued that the « assurance problem » formulated by Amartya Sen appears more relevant than the well-known « prisoner's dilemma » in some respects. Our analysis also reveals some ambiguities in Hobbes' political philosophy that may lead to diverse interpretations and judgments about his role in the history of liberalism.

  9. Concomitant radiochemotherapy with 5-FU and cisplatin for invasive bladder cancer. Acute toxicity and first results

    Energy Technology Data Exchange (ETDEWEB)

    Birkenhake, S.; Leykamm, S.; Sauer, R. [Friedrich-Alexander Univ., Erlangen-Nuernberg (Germany). Dept. of Radiooncology; Martus, P. [Friedrich-Alexander Univ., Erlangen-Nuernberg (Germany). Dept. of Medical Statistics

    1999-03-01

    Purpose: To evaluate acute toxicity and efficacy of simultaneous radiochemotherapy for invasive urothelial cancer of the bladder. Patients and Methods: From September 1993 to July 1997, 61 patients with invasive bladder cancer were treated with a transurethral resection (TURB) followed by radiochemotherapy (RCT). Twenty-five received a combination of 5-FU and cisplatin. The prescribed doses were 600 mg/m{sup 2} 5-FU daily as continuous infusion over 5 days each in the 1st and 5th treatment week and 20 mg/m{sup 2} cisplatin daily at the same days as a short infusion. The pelvis was irradiated with 54 Gy, the bladder with 59.4 Gy and the paraortic nodes in 7 cases with 45 Gy, respectively. Six to 8 weeks after RCT a second TURB was performed for reasons of restaging. Results: Twenty out of 25 patients received at least 80% of the prescribed chemotherapy, in 13 cases the full dose could be given. Gastrointestinal toxicity of Grade I and II occurred in 10 cases, 1 patient developed severe diarrhea (Grade VI). After the 1st course of chemotherapy 7 patients had leuco- or thrombopenia of Grade III. One patient had a leucopenia of Grade IV. After the 2nd course 4 patients developed Grade III leuko- and thrombopenia, 1 of Grade IV. Two Grade II anemia were found. All more severe toxicities and necessary dose reductions were related to radiation of the paraaortic nodes. No life threatening infections, bleedings or cardiotoxicity was found. Restaging TURBs resulted in 22 complete remissions, 1 patient had a de-novo-carcinoma (Tis) at this time, 2 were non-responders (8%). After a median follow-up of 38 months 20 patients are alive (80%). Conclusions: 1. If irradiation of paraaortic nodes is necessary, 5-FU should not be applied, because the gastrointestinal toxicity is too extensive. In all other cases side effects are tolerable and can be managed by supportive care. 2. The first results are promising and should be evaluated in a prospective study. (orig.) [Deutsch

  10. Synthesis of liver-targeting dual-ligand modified GCGA/5-FU nanoparticles and their characteristics in vitro and in vivo.

    Science.gov (United States)

    Cheng, Mingrong; Gao, Xiaoyan; Wang, Yong; Chen, Houxiang; He, Bing; Li, Yingchun; Han, Jiang; Zhang, Zhiping

    2013-01-01

    Nanoparticle drug delivery systems using polymers hold promise for clinical applications. We synthesized dual-ligand modified chitosan (GCGA) nanoparticles using lactic acid, glycyrrhetinic acid, and chitosan to target the liver in our previous studies. We then synthesized the GCGA/5-FU nanoparticles by conjugating 5-fluorouracil (5-FU) onto the GCGA nanomaterial, which had a mean particle size of 239.9 nm, a polydispersity index of 0.040, a zeta potential of +21.2 mV, and a drug loading of 3.90%. GCGA/5-FU nanoparticles had good slow release properties, and the release process could be divided into five phases: small burst release, gentle release, second burst release, steady release, and slow release. Inhibitory effects of GCGA/5-FU on tumor cells targeted the liver, and were time and dose dependent. GCGA nanoparticles significantly prolonged the efficacy of 5-FU on tumor cells, and alleviated the resistance of tumor cells to 5-FU. GCGA/5-FU nanoparticles were mostly concentrated in the liver, indicating that the GCGA nanoparticles were liver targeting. GCGA/5-FU nanoparticles significantly suppressed tumor growth in orthotopic liver transplantation mouse model, and improved mouse survival.

  11. THE EFFECT OF LIVER MACROPHAGES ON INVITRO CYTOLYTIC ACTIVITY OF 5FU AND FUDR ON COLON-CARCINOMA CELLS - EVIDENCE OF MACROPHAGE ACTIVATION

    NARCIS (Netherlands)

    DAEMEN, T; REGTS, J; MORSELT, H; SCHERPHOF, GL

    1992-01-01

    While investigating the effects of 5-fluorouracil (5FU) and 5-fluoro-2'-deoxyuridine (FUdR) on the tumoricidal state of rat liver macrophages activated in vitro by means of liposome-encapsulated muramyl dipeptide (MDP), we observed that 5FU in combination with macrophages produced substantially high

  12. The soluble EP2 receptor FuEP2/Ex2 suppresses endometrial cancer cell growth in an orthotopic xenograft model in nude mice.

    Science.gov (United States)

    Takahashi, Tetsuyuki; Ogawa, Hirohisa; Izumi, Keisuke; Uehara, Hisanori

    2011-07-01

    Endometrial cancer is one of the most common gynecologic malignancies and many factors influence in its growth and development. As in many other types of cancer, prostaglandin E(2) (PGE(2)) is thought to be an accelerator of cell proliferation and endometrial cancer progression. In this study, we examined the effect of FuEP2/Ex2, a soluble decoy receptor for PGE(2) on growth of endometrial cancer cells. A stable transfectant expressing FuEP2/Ex2 was established from human endometrial cancer Ishikawa cells (Ish-FuEP2/Ex2). Ish-FuEP2/Ex2 cells expressed FuEP2/Ex2 mRNA and protein. Expression levels of E-prostanoid receptor 1 (EP1), EP2, EP3, EP4, and F-prostanoid receptor (FP) were almost the same in Ish-FuEP2/Ex2 and vector control cells. Growth rates of Ish-FuEP2/Ex2 under normal culture conditions were also similar to vector control cells, although PGE(2)-induced growth stimulation was completely inhibited in Ish-FuEP2/Ex2 or by Ish-FuEP2/Ex2 culture medium. Moreover, phosphorylation of extracellular signal-regulated kinase (ERK) and induction of cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF), cyclin D1, and c-fos mRNA by PGE(2) were not observed in Ish-FuEP2/Ex2 and Ish-FuEP2/Ex2 culture medium-treated vector control cells, although they were found when treated with prostaglandin F(2α). An orthotopic xenograft model in athymic nude mice revealed that Ish-FuEP2/Ex2-injected mice had significantly decreased mean tumor area. The proportion of Ki-67-positive cells in the tumor lesion was also significantly lower in Ish-FuEP2/Ex2-injected mice. These findings suggest that an EP-targeting strategy using FuEP2/Ex2 may be of use in the treatment of endometrial cancer.

  13. FU Orionis outbursts, preferential recondensation of water ice, and the formation of giant planets

    CERN Document Server

    Hubbard, Alexander

    2016-01-01

    Ices, including water ice, prefer to recondense onto pre-existing nuclei rather than spontaneously forming grains from a cloud of vapor. Interestingly, different potential recondensation nuclei have very different propensities to actually nucleate water ice at the temperatures associated with freeze-out in protoplanetary discs. Therefore, if a region in a disc is warmed and then recooled, water vapor should not be expected to refreeze evenly onto all available grains. Instead it will preferentially recondense onto the most favorable grains. When the recooling is slow enough, only the most favorable grains will nucleate ice, allowing them to recondense thick ice mantles. We quantify the conditions for preferential recondensation to rapidly create pebble-sized grains in protoplanetary discs and show that FU Orionis type outbursts have the appropriate cooling rates to drive pebble creation in a band about 5 astronomical units wide outside of the quiescent frost line from approximately Jupiter's orbit to Saturn's...

  14. 宋玉《讽赋》之讽%Critics on Feng Fu by Songyu

    Institute of Scientific and Technical Information of China (English)

    刘刚

    2012-01-01

    Feng Fu written by Songyu is a piece of critics on the statement of "Chu Xiangwang is lecherous". It generalizes the rules of female' s showing of love and basic principles of male' s self-control, which provides references for monarchs to identify woman' s charm. The nature of it is to prevent obscene.%宋玉的《讽赋》是针对“楚襄王好女色”的专题讽谏文章,全文借自我辩白,概括了女性示爱的典型规律和男性自律的基本规范,为君王认知女色和应对女色提供了经验性借鉴,其讽谏的实质是止欲与戒淫。

  15. From specific training to global shift of manual preference in Kung Fu experts.

    Science.gov (United States)

    Maeda, Rodrigo S; Souza, Rosana M; Teixeira, Luis A

    2014-02-01

    Manual preference and intermanual performance asymmetry have been approached from a multidimensional and dynamic perspective. A point of interest from that approach is the role of lateralized motor experiences on handedness. In this study, intermanual performance asymmetry in sport-specific movements and manual preference in daily living tasks were compared between Kung Fu athletes and novices. Analysis of movement time in the performance of interlaterally symmetric and asymmetric movement patterns showed smaller intermanual performance asymmetry in experts. Analysis of manual preference using the Edinburgh Handedness Inventory indicated that experts presented predominantly weak or moderate strength of right hand preference. Novices, conversely, were found to have predominantly strong right hand preference. These results suggest that extensive bimanual training by experts leads to a global shift of manual preference, affecting hand selection in distinct tasks.

  16. Translasi Pencak Silat Kedalam Film Animasi (Studi Kasus Film Kung Fu Panda

    Directory of Open Access Journals (Sweden)

    Riyo Ramadhan

    2017-09-01

    Full Text Available Abstrak. Sebagai tradisi yang telah membudaya dari sejak zaman dahulu kala, pencak silat lahir sebagai benteng kekuatan pertahanan diri sekaligus menjadi seni yang memperkaya khazanah kebudayaan bangsa Indonesia. Namun, kuatnya terpaan kebudayaan seni bela diri impor yang masuk (karate, kung fu, tae kwon do, muay thai, capoeira, dll, yang selalu didukung dengan berbagai kemasan media entertainment modern, membuat silat menjadi kalah populer bahkan di mata dan persepsi masyarakat Indonesia sendiri. Hal ini mengakibatkan para generasi muda memandang seni bela diri impor menjadi lebih superior ketimbang pencak silat. Jika hal ini terus berlangsung tanpa ada usaha untuk mengembangkan pencak silat melalui media modern, maka akan sangat sulit untuk mempertahankan dan mengembangkan tradisi ini di masa depan. Tujuan dari makalah ini ialah untuk membuktikan dan menggali potensi animasi sebagai media alternatif yang efektif untuk memvisualisasikan adegan dan cerita bertemakan pencak silat. Adapun studi kasus yang menjadi acuan dalam penelitian ialah film animasi “Kung Fu Panda”. Penelitian ini mengkaji studi kasus dengan menggunakan metode kualitatif deskriptif, lalu dianalisis dengan pendekatan analisis deskriptif untuk mengkaji dan mengidentifikasi pemasalahan dan solusi. Pembahasan dari makalah lebih ditekankan pada kekuatan penyampaikan cerita melalui gambar (visual storytelling yang efektif terkait dengan pencak silat. Hasil dari penelitian ialah cara penyampaian pesan yang efektif mengenai elemen dan esensi pencak silat sebagai bentuk translasinya kedalam film animasi. Pesan tersebut dapat disampaikan dengan menggunakan aspek narasi, gesture, dan simbol yang diakomodasi dengan aspek visual storytelling. Abstract. A tradition that has been part of Indonesian culture since ancient times, pencak silat was born as a form of self-defense and at the same time has grown into an art form that belongs to the cultural treasures of the Indonesian nation

  17. The Protective Effects of Shen-Fu Injection on Experimental Acute Pancreatitis in a Rat Model

    Directory of Open Access Journals (Sweden)

    Lei Huang

    2014-01-01

    Full Text Available Objectives. In the present study, we investigated the protective effects of Shen-Fu injection (SFI on a caerulein-induced rat pancreatitis (AP model. Methods. SFI was given to rats in the SFI treated group through intraperitoneal injection. Blood and pancreas samples were collected for serological and histopathological studies. Results. Our results showed that AP caused significant decrease in tissue glutathione (GSH and serum IL-4 and IL-10, while pancreatic malondialdehyde (MDA and myeloperoxidase (MPO were increased. Furthermore, TNF-α, IL-1β, amylase, and lipase levels were also significantly increased. On the other hand, SFI treatment reserved all these biochemical indices as well as histopathologic alterations that were induced by caerulein. Conclusion. Our findings suggest that the SFI protects against caerulein-induced AP in rats via modulation of cytokines, oxidative stress, and Nuclear Factor-kappa B (NF-κB activity.

  18. Development and Characterization of Novel Site Specific Hollow Floating Microspheres Bearing 5-Fu for Stomach Targeting

    Directory of Open Access Journals (Sweden)

    Peeyush Bhardwaj

    2014-01-01

    Full Text Available Multiple-unit-type oral floating hollow microspheres of 5-fluorouracil (5-Fu were developed using modified solvent evaporation technique to prolong gastric residence time, to target stomach cancer, and to increase drug bioavailability. The prepared microspheres were characterized for micromeritic properties, floating behavior, entrapment efficiency, and scanning electron microscopy (SEM. The in vitro drug release and floating behavior were studied in simulated gastric fluid (SGF at pH 1.2. The yield of microspheres was obtained up to 84.46±6.47%. Microspheres showed passable flow properties. Based on optical microscopy, particle size was found to be ranging from 158.65±12.02 to 198.67±17.45 μm. SEM confirmed spherical size, perforated smooth surface, and a hollow cavity inside the microspheres. Different kinetic models for drug release were also applied on selected batches.

  19. The Proximity of Ribosomal Protein Genes to oriC Enhances Vibrio cholerae Fitness in the Absence of Multifork Replication

    Science.gov (United States)

    Soler-Bistué, Alfonso; Timmermans, Michaël

    2017-01-01

    ABSTRACT Recent works suggest that bacterial gene order links chromosome structure to cell homeostasis. Comparative genomics showed that, in fast-growing bacteria, ribosomal protein genes (RP) locate near the replication origin (oriC). We recently showed that Vibrio cholerae employs this positional bias as a growth optimization strategy: under fast-growth conditions, multifork replication increases RP dosage and expression. However, RP location may provide advantages in a dosage-independent manner: for example, the physical proximity of the many ribosomal components, in the context of a crowded cytoplasm, may favor ribosome biogenesis. To uncover putative dosage-independent effects, we studied isogenic V. cholerae derivatives in which the major RP locus, S10-spc-α (S10), was relocated to alternative genomic positions. When bacteria grew fast, bacterial fitness was reduced according to the S10 relative distance to oriC. The growth of wild-type V. cholerae could not be improved by additional copies of the locus, suggesting a physiologically optimized genomic location. Slow growth is expected to uncouple RP position from dosage, since multifork replication does not occur. Under these conditions, we detected a fitness impairment when S10 was far from oriC. Deep sequencing followed by marker frequency analysis in the absence of multifork replication revealed an up to 30% S10 dosage reduction associated with its relocation that closely correlated with fitness alterations. Hence, the impact of S10 location goes beyond a growth optimization strategy during feast periods. RP location may be important during the whole life cycle of this pathogen. PMID:28246358

  20. The ALMA early science view of FUor/EXor objects - I. Through the looking-glass of V2775 Ori

    Science.gov (United States)

    Zurlo, Alice; Cieza, Lucas A.; Williams, Jonathan P.; Canovas, Hector; Perez, Sebastian; Hales, Antonio; Mužić, Koraljka; Principe, David A.; Ruíz-Rodríguez, Dary; Tobin, John; Zhang, Yichen; Zhu, Zhaohuan; Casassus, Simon; Prieto, Jose L.

    2017-02-01

    As part of an Atacama Large Millimeter/submillimiter Array (ALMA) survey to study the origin of episodic accretion in young eruptive variables, we have observed the circum-stellar environment of the star V2775 Ori. This object is a very young, pre-main sequence object which displays a large amplitude outburst characteristic of the FUor class. We present Cycle-2 band 6 observations of V2775 Ori with a continuum and CO (2-1) isotopologue resolution of 0.25 arcsec (103 au). We report the detection of a marginally resolved circum-stellar disc in the ALMA continuum with an integrated flux of 106 ± 2 mJy, characteristic radius of ˜30 au, inclination of 14.0^{+7.8}_{-14.5} deg and is oriented nearly face-on with respect to the plane of the sky. The 12CO emission is separated into distinct blue and redshifted regions that appear to be rings or shells of expanding material from quasi-episodic outbursts. The system is oriented in such a way that the disc is seen through the outflow remnant of V2775 Ori, which has an axis along our line of sight. The 13CO emission displays similar structure to that of the 12CO, while the C18O line emission is very weak. We calculated the expansion velocities of the low- and medium-density material with respect to the disc to be of -2.85 (blue), 4.4 (red) and -1.35 and 1.15 km s-1 (for blue and red) and we derived the mass, momentum and kinetic energy of the expanding gas. The outflow has an hourglass shape where the cavities are not seen. We interpret the shapes that the gas traces as cavities excavated by an ancient outflow. We report a detection of line emission from the circumstellar disc and derive a lower limit of the gas mass of 3 MJup.

  1. The role of effective mass and hand speed in the performance of kung fu athletes compared with nonpractitioners.

    Science.gov (United States)

    Neto, Osmar Pinto; Magini, Marcio; Saba, Marcelo M F

    2007-05-01

    The main goal of this article is to quantify the contribution of effective mass (me) and handspeed (shi) on the palm strike performance of kung fu athletes (kung fu group) compared with nonpractitioners (control group). All subjects were asked to strike a basketball. Hand and ball speed (sbf) were determined by high-speed video analysis. The value for me was determined by an equation that does not depend upon postimpact measurement of the hand speed. The results show that kung fu athletes had greater shi (6.67 [SD 1.42] m/s), p = 0.042), higher me (2.62 [SD 0.33] kg, p = 0.004), and greater sbf (9.00 [SD 1.89] m/s), p = 0.004) than the nonpractitioners (5.04 [SD 0.57] m/s, 1.33 [SD 0.19] kg, and 5.72 [SD 0.44] m/s, respectively). Comparing the average values obtained for me and hand and forearm mass (m), it was found that for the control group me is statistically equal to m (p = 0.917), whereas for the kung fu group me is significant greater than m (p = 0.003). It is suggested that for impacts against heavier objects, the effective mass would be the main factor to distinguish a martial arts-trained from an untrained subject.

  2. Effects of 5-FU combined compound Ginseng and Astragalus on biological behavior of human gastric cancer MGC-803 cells

    Institute of Scientific and Technical Information of China (English)

    韦尉元

    2013-01-01

    Objective To observe the in vitro effects of 5-fluorouracil(5-FU) combined Compound Ginseng and Astragalus(CGA) on the biological behaviors such as the proliferation,the cloning,apoptosis and migration of human gastric cancer MGC-803 cells. Methods The cell proliferation inhibition rate was detected by MTT assay,

  3. Cell Line Derived 5-FU and Irinotecan Drug-Sensitivity Profiles Evaluated in Adjuvant Colon Cancer Trial Data

    DEFF Research Database (Denmark)

    Buhl, Ida Kappel; Gerster, Sarah; Delorenzi, Mauro

    2016-01-01

    patients who benefitted from the addition of irinotecan to 5-FU, we used gene expression profiles based on cell lines and clinical tumor material. These profiles were applied to expression data obtained from pretreatment formalin fixed paraffin embedded (FFPE) tumor tissue from 636 stage III colon cancer...

  4. Deeply embedded objects and shocked molecular hydrogen : The environment of the FU Orionis stars RNO 1B/1C

    NARCIS (Netherlands)

    Quanz, S. P.; Henning, Th.; Bouwman, J.; Linz, H.; Lahuis, F.

    2007-01-01

    We present Spitzer IRAC and IRS observations of the dark cloud L1287. The mid-infrared ( MIR) IRAC images show deeply embedded infrared sources in the vicinity of the FU Orionis objects RNO 1B and RNO 1C, suggesting their association with a small young stellar cluster. We resolve for the first time

  5. 江淹赋的用典%The use of allusions in JIANG Yan's Fu

    Institute of Scientific and Technical Information of China (English)

    辛玲; 王卫振

    2011-01-01

    "Jiang lang cai jin" is the story of JIANG Yan,who is a famous writer of Fu.The Hen Fu and Bie Fu are the most famous masterpieces of him.In this paper,the allusions in JIANG Yan's fifteen Fu are summed up,analyzed and classified,on the basis,its features are concluded in order to provide more materials for Chinese allusion research.%"江郎才尽"典故中的主人公江淹是魏晋南北朝时期的著名赋作家,其《恨赋》与《别赋》最为著名,其中典故的运用也值得研究一番。本文主要对江淹的十五篇赋作中出现的典故进行总结,然后分类分析研究,最后得出其运用时所表现的特点,为汉语典故的研究提供更多的材料。

  6. Effect of cholesterol on behavior of 5-fluorouracil (5-FU) in a DMPC lipid bilayer, a molecular dynamics study.

    Science.gov (United States)

    Khajeh, Aboozar; Modarress, Hamid

    2014-01-01

    In this work, molecular dynamics (MD) simulations were performed to investigate the effects of cholesterol on the interaction between the hydrophilic anticancer drug, 5-FU, and fully hydrated 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) bilayer. Several structural and dynamical parameters of DMPC bilayers with varying amounts of cholesterol (0, 25, and 50mol%) in the presence and absence of drug molecules were calculated. Moreover, the free energy barriers for translocation of one 5-FU molecule from water to the lipid bilayer were determined by using the potential of mean force (PMF). PMF studies indicated that the location of the maximum free energy barrier was in the hydrophobic middle region of bilayer, while the minimums of the barrier were located at the hydrophilic part of bilayer at the interface with water. The minimum and maximum of the free energy profiles were independent of cholesterol concentration and suggested that the drug molecules 5-FU were accumulated in the vicinity of the polar head group of lipid bilayers. Moreover, the results showed that with increasing cholesterol concentration in the bilayer, the free energy barrier for translocation of 5-FU across the bilayer also increases which can be attributed to the condensing effect of the cholesterol on the bilayer.

  7. Assessment of surface concentrations in resorbable ocular implants: controlled drug delivery devices for 5-fluorouracil (5-FU)

    Science.gov (United States)

    Milne, Peter J.; Gautier, Sandrine; Parel, Jean-Marie A.; Jallet, Valerie

    1997-05-01

    The antineoplastic drug 5-fluorouracil (5-fluoro- 2,4,(1H,3H)-pyrimidinedione; 5-FU) has been used to control proliferation of penetrating fibroblasts and to prevent channel closure following glaucoma filtration surgery (trabeculectomy) or laser sclerectomy. Because of the toxicity of the drug, administration of low dosages slowly over time, at the site of the desired treatment, is indicated for optimum efficacy. Repeated injections of low dosages of the drug represent an undesirable intervention and may also result in unwanted toxicity to the corneal epithelium. A suitable biocompatible and resorbable polymer matrix composed of a poly (D,L-lactic-co-glycolic acid: PLGA) has been admixed with varying amounts of 5-FU and cast as shapes suitable for intracorneal implantation. Slow biodegradation of this polymer over a one to two week period has been shown to result in an acceptably slow drug release mechanism. An issue arising during the clinical evaluation of the efficacy of this drug delivery system was how best to quantify the concentration of 5-FU and its distribution spatially in the solid implant. FT-IR and FT-Raman spectroscopies distinguishes between the drug and the polymer matrix and were used to differentiate and quantitate the 5-FU concentration of the implants.

  8. TS Gene Polymorphisms Are Not Good Markers of Response to 5-FU Therapy in Stage III Colon Cancer Patients

    Directory of Open Access Journals (Sweden)

    A. Fariña-Sarasqueta

    2010-01-01

    Full Text Available Aim: Although the predictive and prognostic value of thymidylate synthase (TS expression and gene polymorphism in colon cancer has been widely studied, the results are inconclusive probably because of methodological differences. With this study, we aimed to elucidate the role of TS gene polymorphisms genotyping in therapy response in stage III colon carcinoma patients treated with 5-FU adjuvant chemotherapy.

  9. Toxicity during l-LV/5FU adjuvant chemotherapy as a modified RPMI regimen for patients with colorectal cancer.

    Science.gov (United States)

    Hotta, Tsukasa; Takifuji, Katsunari; Arii, Kazuo; Yokoyama, Shozo; Matsuda, Kenji; Higashiguchi, Takashi; Tominaga, Toshiji; Oku, Yoshimasa; Yamaue, Hiroki

    2005-08-01

    l-leucovorin (LV)/5-fluorouracil (5FU) may play an important role, as an adjuvant chemotherapy, in improving the survival of patients with stage III colorectal cancer. However, severe toxicity of the chemotherapeutic agent could be fatal. Adverse effects, including bone marrow suppression, liver damage, renal damage, and glucose tolerance, were evaluated daily during 3 courses of l-LV/5FU-modified RPMI regimen adjuvant chemotherapy for 22 patients with stage III colorectal cancer. Decrease in the serum levels of neutrophils and platelets occurred in the 1st course, which became more obvious after three or four administrations of l-LV/5FU in the 1st course. Furthermore, serum levels of leukocytes, neutrophils, and platelets on the re-start day of this chemotherapy after 2-week intervals were lower than those on the start day of this chemotherapy. In the evaluation of liver damage, renal damage, and glucose tolerance; serum alanine aminotransferase level in the 2nd course, serum total bilirubin (T.Bil) level in the 1st course, and serum creatinine level in the 1st course deteriorated during the course. T.Bil levels on the re-start day of this chemotherapy after 2-week intervals were especially high compared to that on the start day. The more courses of this chemotherapy we perform, the more attention we must pay to bone marrow suppression and hyperbilirubinemia. Thus, we clarified the attentive point of side effect of l-LV/5FU adjuvant chemotherapy for colorectal cancer.

  10. Adjuvant 5FU plus levamisole in colonic or rectal cancer: improved survival in stage II and III.

    Science.gov (United States)

    Taal, B G; Van Tinteren, H; Zoetmulder, F A

    2001-11-16

    Based on the first favourable results of adjuvant therapy of 5FU plus levamisole in Dukes C colonic cancer in 1990, we conducted a prospective trial. 1029 patients were randomised to receive one year 5FU plus levamisole or no further treatment following curative surgery for stage II or III colon (n = 730) or rectal cancer (n = 299). 45% were in stage II and 55% in stage III. With a median follow-up of 4 years and 9 months a significant reduction in odds of death (25%, SD 9%, P = 0.007) was observed for those with adjuvant treatment (65% at 5 year) compared to the observation group (55%). Improved relative survival was present in stage III (56% vs 44%), and in stage II patients (78% vs 70%). In rectal cancer a non-significant difference in disease-free or overall survival was observed. Distant metastases developed in 76%, while local recurrence alone occurred in 14%. An early start of adjuvant treatment (5FU plus levamisole was 69%. Severe toxicity did not occur. In conclusion, one year 5FU plus levamisole was of benefit in stage II and III colonic cancer; in rectal cancer a significant positive effect could not be demonstrated.

  11. Synthesis and characterization of insulin-5-Fu conjugate,enabling insulin as multi-drug carder via dendritic approach

    Institute of Scientific and Technical Information of China (English)

    Juan Huang; Jian Wei Wang; Tao Gong; Zhi Rong Zhang

    2007-01-01

    To enable insulin as multi-drug carrier, we designed and synthesized dendritic linker molecule bearing three 5-fluorouracil residues at the branch ends. The new conjugate showed excellent water solubility. The stabilities under different conditions were investigated. The results showed that the conjugate was a potential prodrug to release free 5-Fu.

  12. Théorie du risque en santé publique: Application aux infections en milieu hospitalier

    OpenAIRE

    Emily, Mathieu

    2009-01-01

    International audience; Nous introduisons une nouvelle approche pour traiter le problème des infections contractées lors d'un séjour hospitalier. En nous inspirant de la théorie du risque en actuariat, nous avons défini un coefficient d'ajustement permettant de quantifier le risque de développer une infection dans un service hospitalier. Ce coefficient caractérise une distribution exponentielle de la fonction de survie et est estimé comme solution d'une équation de Lundberg. La robustesse des...

  13. Quelle théorie pour la gouvernance?De la gouvernance actionnariale à la gouvernance cognitive et comportementale

    OpenAIRE

    Gérard Charreaux

    2011-01-01

    Le champ du gouvernement ou de la gouvernance des entreprises est constitué par l’analyse des règles du jeu managérial, lesquelles, en encadrant la latitude décisionnelle des dirigeants, conditionnent la création de valeur organisationnelle et, plus globalement, la performance économique. Cet article a deux principaux objectifs. Premièrement, il vise à présenter les principales théories de la gouvernance en explicitant les modèles de création et de répartition de la valeur qui les sous-tenden...

  14. Absorption and distribution characteristics of 5-fluorouracil (5-FU) after an application to the liver surface in rats in order to reduce systemic side effects.

    Science.gov (United States)

    Kodama, Yukinobu; Fumoto, Shintaro; Nishi, Junya; Nakashima, Mikiro; Sasaki, Hitoshi; Nakamura, Junzo; Nishida, Koyo

    2008-05-01

    The present study was undertaken to elucidate the absorption and distribution characteristics of 5-fluorouracil (5-FU) after its application to the liver surface in rats to examine the possibility of reducing the systemic side effects of this agent. 5-FU was applied to the surface of the liver by employing a cylindrical diffusion cell. Approximately 69% of the dose was absorbed in 360 min. The time course of the change in the amount of 5-FU remaining in the diffusion cell obeyed first-order kinetics. Also, a linear relationship was observed between the apparent permeability coefficient, P app, and the reciprocal of the square root of the molecular weight of several compounds including 5-FU. The estimated P app value of 5-FU was in good agreement with the experimental value. The plasma concentration of 5-FU was low (5-FU was rapidly eliminated from the plasma and could not be detected at 120 min. In the analysis of tissue distribution, the liver was divided into three sites; the region under the diffusion cell attachment site (site 1), the treated lobe excluding site 1 (site 2), and untreated lobes (site 3). After being administered i.v., 5-FU mainly distributed in the kidney, and the concentration in the liver was significantly lower than that in kidney, spleen, or heart. After its application to the liver surface, however, 5-FU preferentially distributed at site 1, and was not detected at the other sites or in other tissues. Thus, these results suggested the possibility of a reduction in the systemic side effect of 5-FU on its application to the liver surface.

  15. The effect on the small bowel of 5-FU and oxaliplatin in combination with radiation using a microcolony survival assay

    Directory of Open Access Journals (Sweden)

    Kjellén Elisabeth

    2009-12-01

    Full Text Available Abstract Background In locally advanced rectal cancer, 5-Fluorouracil (5-FU-based chemoradiation is the standard treatment. The main acute toxicity of this treatment is enteritis. Due to its potential radiosensitizing properties, oxaliplatin has recently been incorporated in many clinical chemoradiation protocols. The aim of this study was to investigate to what extent 5-FU and oxaliplatin influence the radiation (RT induced small bowel mucosal damage when given in conjunction with single or split dose RT. Methods Immune competent balb-c mice were treated with varying doses of 5-FU, oxaliplatin (given intraperitoneally and total body RT, alone or in different combinations in a series of experiments. The small bowel damage was studied by a microcolony survival assay. The treatment effect was evaluated using the inverse of the slope (D0 of the exponential part of the dose-response curve. Results In two separate experiments the dose-response relations were determined for single doses of RT alone, yielding D0 values of 2.79 Gy (95% CI: 2.65 - 2.95 and 2.98 Gy (2.66 - 3.39, for doses in the intervals of 5-17 Gy and 5-10 Gy, respectively. Equitoxic low doses (IC5 of the two drugs in combination with RT caused a decrease in jejunal crypt count with significantly lower D0: 2.30 Gy (2.10 - 2.56 for RT+5-FU and 2.27 Gy (2.08 - 2.49 for RT+oxaliplatin. Adding both drugs to RT did not further decrease D0: 2.28 Gy (1.97 - 2.71 for RT+5-FU+oxaliplatin. A clearly higher crypt survival was noted for split course radiation (3 × 2.5 Gy compared to a single fraction of 7.5 Gy. The same difference was seen when 5-FU and/or oxaliplatin were added. Conclusion Combining 5-FU or oxaliplatin with RT lead to an increase in mucosal damage as compared to RT alone in our experimental setting. No additional reduction of jejunal crypt counts was noted when both drugs were combined with single dose RT. The higher crypt survival with split dose radiation indicates a

  16. 汉代赋颂关系析论%The Relation of Han Fu and Ode

    Institute of Scientific and Technical Information of China (English)

    丁玲

    2014-01-01

    In Han dynasty , ode and Fu ( descriptive prose interspersed with verse ) were close in form,which may be the result of the latter on the former or due to the fact that the style of ode was not mature enough then and dependent on Han Fu .Ode was addressed as Fu in Han considering that Fu was more inclusive;when Fu was called ode to highlight the subject of “de-scriptive” and “beauty priority” in fu;another reason was that the two words shared some meanings.In Han,they were called “Fusong”.There are possibly three reasons:(1) the both genres are in the “six poems”;(2) they were both court literature;(3) ode was more depend-ent on Fu then .%汉代颂与赋体貌接近,这一方面和汉赋文体对颂体的影响有关,另一方面则是由于颂的文体规范尚未形成,颂论多依附赋论。汉代存在赋、颂混称和连称的现象。汉人称颂为赋,是由于汉代赋在广义上包含颂;称赋为颂,一是为强调赋中“述形容”且“美盛德”的内容,二是由于“赋”“颂”字义有相通点。汉代“赋颂”连称,原因有三:一是赋与颂并在“六诗”之中,“六诗”之名,后来多两两相合;二是由于赋、颂在汉代皆属宫廷文学,宫廷作家多赋、颂兼擅;三是汉代颂论对赋论的依附。

  17. Théorie de la justice et idéologie : Hume et Rawls

    Directory of Open Access Journals (Sweden)

    Eléonore Le Jallé

    2008-04-01

    Full Text Available Les points d’accord entre Rawls et Hume vont au-delà du seul repérage des « circonstances de la justice ». Même si Hume se trouve attaché à la théorie utilitariste de l’impartialité que Rawls rejette, Hume n’est pas, selon Rawls, « à proprement parler » utilitariste : il a su reconnaître l’idée selon laquelle les institutions doivent fonctionner dans l’intérêt de chacun. L’idée d’une coopération sociale en vue de l’avantage mutuel est donc commune à ces deux auteurs. Ils partagent, en outre, une attitude similaire face au « problème de la confiance » en lien avec la stabilité de la justice : l’un et l’autre ajoutent ainsi à la solution extérieure qu’est l’institution étatique, un facteur intrinsèque de stabilité, à savoir, le sens de la justice. L’idée de « justice procédurale » et le rejet, corrélatif, d’un critère indépendant du juste, les relie également ; d’où, enfin, une certaine analogie des critiques respectivement adressées à ces deux auteurs.The specification of the “circumstances of justice” is not the only point on which Rawls agrees with Hume. If Rawls rejects the utilitarian theory of impartiality which is “reminiscent of Hume”, he does not consider him as “strictly speaking utilitarian”. Indeed, Rawls thinks that Hume has well understood that institutions have to be to the advantage of everyone. Besides, Hume and Rawls agree in thinking that the stability of justice involves a public sense of justice. Finally, the idea of “pure procedural justice” is shared by these authors: both have rejected any independent criterion for the right result, so that the ways they were criticized are rather similar.

  18. The Cloning of Plasmid Replicon ori165 from Bacillus thuringiensis subsp, thenebrionis%苏云金芽胞杆菌拟步行甲亚种质粒复制子ori165的克隆

    Institute of Scientific and Technical Information of China (English)

    魏芳; 孙明; 喻子牛

    2002-01-01

    以苏云金芽胞杆菌拟步行甲亚种菌株( Bacillus thuringiensis subsp, tenebrionis ) YBT- 1765作为出发菌株,克隆了一个包含复制子的EcoRI酶切片段,大小约为11kb,称为oril65.这是国内外从此亚种中克隆到的第一个复制子.缩小到8kb左右后仍然能够复制.杂交结果显示,此复制子来源于菌株YBT-1765可以检测到的分子量最大的质粒.以此复制子构建的穿梭载体pBMB6071在不同受体菌中的稳定性差异很大,其中在以色列亚种无晶体突变株4Q7中,传40后代,稳定性100%.质粒pBMB6071与含ori1030和ori2062在库斯塔克亚种无晶体突变株BMB1 71中是相容的.

  19. Low Impact Development Intensive Rural Construction Planning in Xu Fu Village Ningbo, China: Planning Review through Rural Resilience Perspective

    Directory of Open Access Journals (Sweden)

    Roosmayri Lovina Hermaputi

    2017-08-01

    Full Text Available Xu Fu Village Ningbo LID Intensive Rural Construction Planning is a cooperation project between Zhejiang University and Ningbo Institute of Technology which named "12th Five-Year National Science and Technology support program-the comprehensive demonstration of the key technology of the beautiful rural construction in the rapid urbanization area of the Yangtze River Delta". This plan focuses on intensive rural construction as part of rural development and construction project that applies the principles of low impact development. Xu Fu Village located in the Yangtze River Delta Region. Currently, the rural growth brings the high impact of development, as a result of rapid urbanization growth arising several issues, such as low land use efficiency, dispersed rural residence, homestead occupies more, rural roads covering over, etc. Meanwhile, Xu Fu village wishes to develop its tourism potential. Thus, the intensive rural construction should be done to avoid the severe effect. The project result hopefully can improve the quality and level of rural residential planning, design, and construction; improve their living environment; save construction land and water use; and improve energy efficiency. The aim of this study is to review the Low Impact Development (LID Intensive Rural Construction in Xu Fu Village, Ningbo City through the rural resilience perspective. This paper will describe the project plan first, then review it through rural resilience perspective. This paper will elaborate the rural resilience theory and then review the rural resiliency through two parts; the first part is identifying rural resilience in rural infrastructure development based on the criteria created by Ayyob S. and Yoshiki Y. (2014, about urban resiliency criteria, and then the second part is reviewing Xu Fu Village resilience through Arup Resilience Qualities (2012, considering three rural resilience domain (economy, ecology, and cultural.

  20. Gelam honey and ginger potentiate the anti cancer effect of 5-FU against HCT 116 colorectal cancer cells.

    Science.gov (United States)

    Hakim, Luqman; Alias, Ekram; Makpol, Suzana; Ngah, Wan Zurinah Wan; Morad, Nor Azian; Yusof, Yasmin Anum Mohd

    2014-01-01

    The development of chemopreventive approaches using a concoction of phytochemicals is potentially viable for combating many types of cancer including colon carcinogenesis. This study evaluated the anti-proliferative effects of ginger and Gelam honey and its efficacy in enhancing the anti-cancer effects of 5-FU (5-fluorouracil) against a colorectal cancer cell line, HCT 116. Cell viability was measured via MTS (3-(4,5-dimethylthiazol-2- yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulphenyl)-2H-tetrazolium) assay showing ginger inhibiting the growth of HCT 116 cells more potently (IC50 of 3mg/mL) in comparison to Gelam honey (IC50 of 75 mg/mL). Combined treatment of the two compounds (3mg/mL ginger+75 mg/mL Gelam honey) synergistically lowered the IC50 of Gelam honey to 22 mg/mL. Combination with 35 mg/mL Gelam honey markedly enhanced 5-FU inhibiting effects on the growth of HCT 116 cells. Subsequent analysis on the induction of cellular apoptosis suggested that individual treatment of ginger and Gelam honey produced higher apoptosis than 5-FU alone. In addition, treatment with the combination of two natural compounds increased the apoptotic rate of HCT 116 cells dose- dependently while treatment of either ginger or Gelam honey combined with 5-FU only showed modest changes. Combination index analysis showed the combination effect of both natural compounds to be synergistic in their inhibitory action against HCT 116 colon cancer cells (CI 0.96 5-FU against colorectal cancer.

  1. Neo-adjuvant chemotherapy with cisplatin and short infusional 5-FU in advanced head and neck malignancies

    Directory of Open Access Journals (Sweden)

    Aich Ranen Kanti

    2005-01-01

    Full Text Available Background: Combination of radical surgery and radiotherapy is the standard management of head and neck malignancies. But due to considerable morbidity of surgery and associated cosmetic and functional deficiencies, often aggravated by adjuvant radiotherapy, many patients prefer only radiotherapy with its′ decreased chance of survival. Proper surgical facilities are also not accessible to most of our patients. Neo-adjuvant chemotherapy and loco-regional management by surgery and / or radiotherapy have emerged as a viable alternative. Aims: The purpose of this study is to find out the survival outcome as well as toxicity profile of Neo-adjuvant chemotherapy with cisplatin and short infusional (3 hours 5-FU followed by radiotherapy in advanced head and neck malignancies. Materials and Methods: From June 2002 to December 2003, seventy four patients with advanced head and neck malignancies were planned to be treated with Cisplatin (50 mg / sq. meter on Days 1 and 2 and 5 - FU (600 mg / sq. meter on Days 1, 2 and 3 by 3 hour infusion on Day care basis. On completion of four cycles of chemotherapy at 21 days interval, all patients were destined to receive 6000 cGy of radiotherapy to the loco - regional site. Results: At one year follow up on completion of therapy, 57% patients were alive and 31% patients were disease free. These 31% patients enjoyed a good quality of life in terms of cosmetic and functional deficits. Toxicities were moderate and easily manageable. Conclusion: The study indicated that neo-adjuvant chemotherapy with Cisplatin and short infusional 5 - FU may be delivered on day care basis and results are comparable with Cisplatin and 96 hours continuous infusional 5 - FU. Thus avoiding the continuous infusional 5 - FU, 7 to 10 days in-patient hospitalization during each cycle may be avoided which is a constrain in developing countries like us.

  2. Dénomination, sens et référence dans une théorie des stéréotypes nominaux

    OpenAIRE

    Anscombre, Jean-Claude

    2009-01-01

    Ce texte pose le problème de la relation entre la référence et la signification, à la lumière du célèbre article de Putnam The Meaning of ‘Meaning’. Cet article s’inspire de l’examen des thèses discutées par Putnam et des solutions envisagées pour proposer une nouvelle théorie sémantique, la théorie des stéréotypes. Après avoir tracé les grandes lignes de cette théorie, l’article examine son application à divers problèmes : connecteurs, polysémie, morpho-sémantique. This article deals with...

  3. Elément coque multicouches basé sur la théorie ZPST pour l'analyse dynamique

    OpenAIRE

    Chettah, Ameur; Chazot, Jean-Daniel

    2010-01-01

    National audience; La théorie de déformation en cisaillement d'ordre p combinée avec la théorie de zig-zag (zig-zag p-order shear deformation theory - ZPST) a été utilisée pour l'analyse modale de structures multicouches. Dans la théorie traditionnelle de Reissner-Mindlin, le champ de déplacement inclus un déplacement linéaire dans le plan qui se traduit par une déformation en cisaillement transverse constante dans l'épaisseur nécessitant ainsi l'introduction d'un facteur de correction de cis...

  4. LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells

    Directory of Open Access Journals (Sweden)

    Shin Jung-Young

    2010-08-01

    Full Text Available Abstract Background As EBV-associated gastric cancer has unique features that are different from EBV (- gastric cancer, EBV is considered to have a key role in gastric carcinogenesis. It has been reported that viral latent membrane protein 2A (LMP2A in EBV-transformed tumor cells activates the phosphatidylinositol 3-kinase (PI3K/AKT pathway, which provides a survival signal and chemo-resistance to cytotoxic anti-cancer drugs. This study was to evaluate anti-proliferative effect and cell cycle change when 5-FU and LY294002 (LY, a selective inhibitor of PI3K, were treated separately or combined with different schedules in EBV positive gastric cancer cell line, SNU-719. Methods After single treatment and sequential combination of 5-FU and LY, cytotoxic activity was measured by MTS assay. When 5-FU and LY were treated in single and sequential combinations, the expression of p-AKT, p-NFkB, p-p53 and bcl-2 was observed on different concentrations by Western blot analysis. We also investigated the effect on apoptosis and cell cycle distribution using flow cytometry. The LMP2A siRNA inhibition was done to confirm the reversal of decreased 5-FU activity and p-AKT. Results When 5-FU was sequentially combined with LY, the combination index (CI value indicated synergistic anti-proliferative effect. The expression of p-AKT and p-NFκB was upregulated by 5-FU alone but sequential treatment of 5-FU and LY decreased the expression of both p-AKT and p-NFκB. When 5-FU was combined with LY, G0/G1 and sub G1 cell population (% increased. When 5-FU was added to the cells transfected with LMP2A siRNA, its anti-proliferative effect increased and the expression of p-AKT decreased. In sequential combination of 5-FU and LY, the expression of p-p53 was increased and bcl-2 expression was diminished compared to 5-FU alone. Conclusion These data suggest that sequential combination of 5-FU and LY induce synergistic cytotoxicity and overcome intrinsic and acquired resistance

  5. LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells.

    Science.gov (United States)

    Shin, Jung-Young; Kim, Jeong-Oh; Lee, Suk Kyeong; Chae, Hiun-Suk; Kang, Jin-Hyoung

    2010-08-13

    As EBV-associated gastric cancer has unique features that are different from EBV (-) gastric cancer, EBV is considered to have a key role in gastric carcinogenesis. It has been reported that viral latent membrane protein 2A (LMP2A) in EBV-transformed tumor cells activates the phosphatidylinositol 3-kinase (PI3K)/AKT pathway, which provides a survival signal and chemo-resistance to cytotoxic anti-cancer drugs. This study was to evaluate anti-proliferative effect and cell cycle change when 5-FU and LY294002 (LY), a selective inhibitor of PI3K, were treated separately or combined with different schedules in EBV positive gastric cancer cell line, SNU-719. After single treatment and sequential combination of 5-FU and LY, cytotoxic activity was measured by MTS assay. When 5-FU and LY were treated in single and sequential combinations, the expression of p-AKT, p-NFkB, p-p53 and bcl-2 was observed on different concentrations by Western blot analysis. We also investigated the effect on apoptosis and cell cycle distribution using flow cytometry. The LMP2A siRNA inhibition was done to confirm the reversal of decreased 5-FU activity and p-AKT. When 5-FU was sequentially combined with LY, the combination index (CI) value indicated synergistic anti-proliferative effect. The expression of p-AKT and p-NF kappaB was upregulated by 5-FU alone but sequential treatment of 5-FU and LY decreased the expression of both p-AKT and p-NF kappaB. When 5-FU was combined with LY, G0/G1 and sub G1 cell population (%) increased. When 5-FU was added to the cells transfected with LMP2A siRNA, its anti-proliferative effect increased and the expression of p-AKT decreased. In sequential combination of 5-FU and LY, the expression of p-p53 was increased and bcl-2 expression was diminished compared to 5-FU alone. These data suggest that sequential combination of 5-FU and LY induce synergistic cytotoxicity and overcome intrinsic and acquired resistance of 5-FU via downregulation of activated p-AKT and

  6. The Ionization Structure of Sharpless 2-264: Multiwavelength Observations of the {\\lambda} Ori H II Region

    CERN Document Server

    Sahan, M

    2016-01-01

    We present velocity-resolved maps taken with the Wisconsin H-Alpha Mapper (WHAM) in H{\\alpha}, [S II] {\\lambda}6716, and [N II] {\\lambda}6583 around the well-known O8 III star {\\lambda} Ori A (HD 36861) (l = 185{\\deg} to 205{\\deg}, b = -24{\\deg} to -1{\\deg}). The integrated intensity (v(LSR) = -80 to +80 km/s), I(H{\\alpha}), within WHAM's one-degree beams varies from ~ 190 R near the center to ~ 10 R on the periphery of the nebula where it becomes comparable to foreground and/or background emission in this complex region. Intensity ratios for [N II]/H{\\alpha} and [S II]/H{\\alpha} average 0.28 and 0.35, respectively. In both ratios, higher values are found preferentially at larger radii from {\\lambda} Ori, although the behavior of [N II]/H{\\alpha} is complicated near the edges of the nebula. The [S II]/[N II] intensity ratio ranges from ~ 0.5 to ~ 1.0, with the value increasing toward larger radii (and lower H{\\alpha} intensities). Variations of [S II]/H{\\alpha}, [N II]/H{\\alpha}, and [S II]/[N II] line ratios...

  7. Mécanique quantique relativiste théories de jauge : cours et exercices corrigés

    CERN Document Server

    Klasen, Michael

    2009-01-01

    Avec la mise en service du plus grand accélérateur du monde, le LHC au CERN, cet ouvrage propose de manière pertinente une introduction pédagogique aux théories décrivant les particules élémentaires à haute énergie. Des rappels de relativité restreinte et du formalisme de Lagrange et Hamilton permettent d'établir une base commune et une notation covariante. Sont ensuite présentées la mécanique quantique relativiste avec les équations de Klein-Gordon et de Dirac, les fonctions de Green et les propagateurs, les théories de jauge abéliennes, comme l'électrodynamique quantique (QED), et non-abéliennes, comme la chromodynamique quantique (QCD), et le mécanisme de Higgs. Les règles de Feynman, qui en sont déduites, offrent une description intuitive sur les interactions entre les constituants fondamentaux et un outil de calcul efficace pour les processus physiques. Chaque chapitre se termine par une série d'exercices corrigés. Le cours reste accessible aux étudiants de master qui ne souhait...

  8. De la théorie des opérateurs aux fondements de la mécanique quantique

    CERN Document Server

    Rinkel, Jean-Marc

    2016-01-01

    Ce livre est destiné aux étudiants en sciences, mathématiques ou physiques, au niveau master. La formalisation de l’infiniment petit de la mécanique quantique est un miracle d’abstraction, d’étonnement et d’émerveillement. Autant le développement de la physique classique (mécaniques newtonienne, lagrangienne, hamiltonienne et relativités) est lié à celui de la géométrie et du calcul tensoriel, autant l’émergence et le développement de la mécanique quantique sont liés à la théorie des espaces de Hilbert et à la théorie de la mesure. Dès lors qu’une observable (ce qui est accessible à une mesure expérimentale) est représentée par un opérateur sur un espace de Hilbert, les mathématiques se chargent de construire des mesures de probabilité sur le spectre de cet opérateur et ces mesures de probabilités deviennent une réalité physique dans les lois de transition de Born. Cet ouvrage décrit de façon précise le passage des mathématiques que l’on vient d’évoquer, �...

  9. Sugar, dental caries and the incidence of acute rheumatic fever: a cohort study of Māori and Pacific children.

    Science.gov (United States)

    Thornley, Simon; Marshall, Roger J; Bach, Katie; Koopu, Pauline; Reynolds, Gary; Sundborn, Gerhard; Ei, Win Le Shwe Sin

    2017-04-01

    To determine whether dental caries, as an indicator of cumulative exposure to sugar, is associated with the incidence of acute rheumatic fever and chronic rheumatic heart disease, in Māori and Pacific children aged 5 and 6 years at their first dental visit. A cohort study was undertaken which linked school dental service records of caries with national hospital discharge and mortality records. Cox models were used to investigate the strength of the association between dental caries and rheumatic fever incidence. A total of 20 333 children who were free of rheumatic heart disease at enrolment were available for analysis. During a mean follow-up time of 5 years, 96 children developed acute rheumatic fever or chronic rheumatic heart disease. After adjustment for potential confounders, children with five or more primary teeth affected by caries were 57% (95% CI: 20% to 106%) more likely to develop disease during follow-up, compared to children whose primary teeth were caries free. The population attributable to the risk for caries in this cohort was 22%. Dental caries is positively associated with the incidence of acute rheumatic fever and chronic rheumatic heart disease in Māori and Pacific children. Sugar intake, an important risk factor for dental caries, is also likely to influence the aetiology of rheumatic fever. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  10. The origin of replication, oriC, and the dnaA protein are dispensable in stable DNA replication (sdrA) mutants of Escherichia coli K-12.

    Science.gov (United States)

    Kogoma, T; von Meyenburg, K

    1983-01-01

    The sdrA224 mutants of Escherichia coli K-12, capable of continued DNA replication in the absence of protein synthesis (stable DNA replication), tolerate inactivation of the dnaA gene by insertion of transposon Tn10. Furthermore, oriC, the origin of E. coli chromosome replication, can be deleted from the chromosome of sdrA mutants without loss of viability. The results suggest the presence of a second, normally repressed, initiation system for chromosome replication alternative to the 'normal' dnaA+ oriC+-dependent initiation mechanism.

  11. Intensité concurrentielle entre lignes de produits rivales:un éclairage par la théorie de la concurrence multimarchés

    OpenAIRE

    Abdelmajid Amine; Faouzi Bensebaa

    2005-01-01

    (VF)Cet article propose une lecture nouvelle et globale des stratégies de marketing produit des entreprises en mobilisant la théorie de la concurrence multimarchés. Il tend à montrer la pertinence de transposer cette théorie au niveau de la rivalité entre lignes de produits et à analyser le lien entre la domination d’une firme dans une ligne de produits et la modification du niveau de concurrence du secteur. À travers une analyse de cas, l’article montre que l’intensité des contacts multimarc...

  12. Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms.

    Science.gov (United States)

    Gaballah, Hanaa H; Gaber, Rasha A; Mohamed, Darin A

    2017-02-01

    Although 5- Fluorouracil (5-FU) has exhibited effectiveness against cancer, novel therapeutic strategies are needed to enhance its antitumor efficiency and modulate its cytotoxity. Apigenin, a flavonoid present in fruits and vegetables, is a potent dietary phytochemical effective in cancer chemoprevention. This study was undertaken to investigate the potential synergistic antitumor activity of apigenin and 5-FU on Solid Ehrlich carcinoma (SEC). Eighty Swiss albino male mice were divided into four equal groups: vehicle treated control SEC, SEC+5-FU, SEC+apigenin, SEC+ 5-FU+apigenin. Beclin-1 and caspases 3, 9 and JNK activities were estimated by ELISA; mRNA expression levels of the antiapoptotic gene Mcl-1 were estimated using quantitative real-time RT-PCR, while tissue malondialdehyde (MDA), glutathione peroxidase and total antioxidant capacity were evaluated spectrophotometrically. A part of the tumor was examined for histopathological and Ki-67 immunohistochemistry analysis. 5-FU and/or apigenin caused significant increase in tissue levels of Beclin-1, caspases 3, 9 and JNK activities, MDA with significant decrease in tumor volume, Mcl-1expression, tissue glutathione peroxidase and total antioxidant capacity and alleviated the histopathological changes with significant decrease of Ki-67 proliferation index compared to vehicle treated SEC control group. The combination of 5-FU and apigenin had a greater effect than each of 5-FU or apigenin alone against solid Ehrlich carcinoma in mice. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. Effect of viscous additives on the absorption and hepatic disposition of 5-fluorouracil (5-FU) after application to liver surface in rats.

    Science.gov (United States)

    Kodama, Yukinobu; Horishita, Miyuki; Fumoto, Shintaro; Mine, Toyoharu; Miyamoto, Hirotaka; Yoshikawa, Naoki; Hirata, Haruna; Sasaki, Hitoshi; Nakamura, Junzo; Nishida, Koyo

    2012-10-01

    Objectives  The aim was to study the effect of viscous additives on the absorption and hepatic disposition of 5-fluorouracil (5-FU) after application to the liver surface in rats. Methods  5-FU solution with or without viscous additives was applied to the rat liver surface with a cylindrical diffusion cell. Then, blood and the remaining solution in the diffusion cell were collected at selected times, followed by excision of the liver. The excised liver was divided into three sites and assayed for 5-FU content. Key findings  The absorption rate of 5-FU from the liver surface was decreased in the presence of carboxymethylcellulose sodium (CMC-Na) and polyvinyl alcohol (PVA) as compared with the control. The k(a) values of PVA 15% and CMC-Na 1% were reduced to about 80 and 67% of the control. The maximum plasma concentration of 5-FU was decreased by incorporation of viscous additives. The 5-FU concentration at the diffusion cell attachment site of the liver (site 1) plateaued at 180 min in the absence of viscous additives. On the other hand, the concentration of 5-FU at site 1 increased in a time-dependent manner until 360 min in the presence of viscous additives. Conclusion  Viscous additives might be useful for retaining drugs at their application site and controlling the rate of absorption from the liver surface.

  14. Preparation and in vitro evaluation of 5-flourouracil loaded magnetite-zeolite nanocomposite (5-FU-MZNC) for cancer drug delivery applications.

    Science.gov (United States)

    Sağir, Tuğba; Huysal, Merve; Durmus, Zehra; Kurt, Belma Zengin; Senel, Mehmet; Isık, Sevim

    2016-02-01

    In this work, super paramagnetic magnetite nanoparticles were synthesized onto/into zeolite, then loaded with anti-cancer drug 5-fluorouracil (5-FU). The physical properties of the prepared nanocomposite and drug loaded nanocomposite were characterized using different techniques. The drug loading and releasing behavior of the magnetic nanocarrier was investigated and the drug-loaded nanoparticles exhibited a sustained release of drug without any burst release phenomenon. Furthermore, 5-FU loaded MZNC were evaluated for its biological characteristics. The functional 5-FU-MZNC has been triggered intra-cellular release of the cancer therapeutic agent 5-fluorouracil (5-FU). Cytotoxic effects of 5-FU loaded MZNC on human gastric carcinoma (AGS) cells were determined by real time cell analysis and colorimetric WST-1 cell viability assay. Apoptosis of cells was further investigated by Annexin-V staining which indicates the loss of cell membrane integrity. According to our results, 5-FU-MZNC showed a concentration-dependent cell proliferation inhibitory function against AGS cells. Morphologic and apoptotic images were consistent with the cytotoxicity results. In conclusion, 5-FU loaded MZNC efficiently inhibit the proliferation of AGS cells in vitro through apoptotic mechanisms, and may be a beneficial agent against cancer, however further animal study is still required.

  15. Rezension von: Ulf Gebken, Söhnke Vosgerau (Hg.: Fußball ohne Abseits. Ergebnisse und Perspektiven des Projekts ‚Soziale Integration von Mädchen durch Fußball‘. Wiesbaden: Springer VS 2014.

    Directory of Open Access Journals (Sweden)

    Robert Claus

    2014-12-01

    Full Text Available Seit 2006 wurden im Rahmen des vom Deutschen Fußball-Bund durchgeführten Modellprojektes „Soziale Integration von Mädchen durch Fußball“ an über 200 Standorten Schul-AGs in sogenannten Brennpunktbezirken aufgebaut. Im vorliegenden Sammelband beleuchten die Autor/-innen ausführlich die Funktion von Sport für die pädagogische Kompetenzvermittlung. Zudem erbringen sie einen umfassenden Projektbericht und leisten ein Plädoyer für die Modernisierung des Verhältnisses zwischen Schule und Vereinen, Lehrplan und Ehrenamt. Somit stellt das Buch, wie auch das Projekt, einen enorm wichtigen Beitrag zur Geschlechtergerechtigkeit im Sport dar. Gleichzeitig jedoch liest sich eine Reihe an Texten etwas zu sperrig für den Bericht einer Praxisforschung, und Begriffe im Feld der ‚Integration’ bleiben schwammig.

  16. Extracellular Disposal of Tumor-Suppressor miRs-145 and -34a via Microvesicles and 5-FU Resistance of Human Colon Cancer Cells

    Directory of Open Access Journals (Sweden)

    Yukihiro Akao

    2014-01-01

    Full Text Available The dysregulation of microRNA (miRNA expression causes various kinds of diseases. Especially, alterations in miRNA expression levels are frequently observed in human tumor cells and are associated with cancer pathogenesis. Earlier we established Fluorouracil (5-FU-resistant human colon cancer DLD-1 cells (DLD-1/5FU from parental 5-FU- sensitive DLD-1 cells. In the present study, we examined the expression of miRNA in each cell line and in its extracellular microvesicles (MVs before and after treatment with 5-FU. The nascent RNAs of anti-oncogenic miR-34a and -145 labeled with EU in both cells were proved to be transferred into MVs in both cell lines. The levels of miR-34a and -145 in the cells and in their MVs were not largely different in the two cell lines, and a substantial amount of both miRNAs was secreted by both cell lines even in the steady-state condition. The exposure of both cell lines to 5-FU significantly increased the intracellular levels of miR-145 and miR-34a in the 5-FU-sensitive DLD-1 cells, whereas the level of neither miR was elevated in the DLD-1/5FU cells. Interestingly, the amount of miR-145 detected in the small MVs shed into the medium of the parental cells was reduced after the treatment with 5-FU. On the other hand, the intracellular expression of miR-34a in the DLD-1/5FU cells was down-regulated compared with that in the parental DLD-1 cells even in the steady-state condition. As to the miR-34a secreted into MVs, the increase in the level in DLD-1/5FU cells was greater than that in the parental DLD-1 cells after the treatment with 5-FU. Thus, the intra- and extracellular miR-145 and -34a were closely associated with 5-FU resistance, and the resistance was in part due to the enhanced secretion of miR-145 and -34a via MVs, resulting in low intracellular levels of both miRNAs.

  17. Study on Shi Bing: This Chapter wasn't Plagiarized from Fu-niao Fu%《鹖冠子·世兵》篇非抄袭贾谊《服鸟鸟赋》辨

    Institute of Scientific and Technical Information of China (English)

    杨兆贵

    2009-01-01

    Liu Zongyuan considered that the Shi Bing Chapter of Ho-Kuan-Tzu was plagiarized from Jia Yi's Fu-niao Fu because there were some same sentences between these two essays. However, this article would reveal that these two essays have used the same quotations from some classics in pre-Qin and Han dynasty, regarding three aspects: writing skills, literature style, authors' and works' thoughts and their historical settings. Therefore, the conclusion should be that they have the same theoretical resources, and were created in a close period. Moreover, Jia Yi wrote the Fu-niao Fu after reading the Shi Bing Chapter. The Shi Bing chapter was probably finished during early Han dynasty according to the study of Cao Mo's tale.%篇有些句子和贾谊相同,柳宗元就认为是抄袭,并而断定是伪书.本文从文体研究、编纂者的思想背景、撰写手法三方面来论证篇与都引用先秦秦汉的典籍,不能证明篇抄袭.相反,两者所反映的思想却有共同的时代背景,且思想重点不同.另外,篇前部分记载曹沫一事,与后部分内容无涉.本文考证曹沫一事,推论本篇写成于战国末期与汉初之间.

  18. Comparative study of microleakage about GC FU ji IX glass ionomer and silver glass ionomer%GC FU ji IX玻璃离子和银粉玻璃离子微渗漏的对比研究

    Institute of Scientific and Technical Information of China (English)

    刘军

    2012-01-01

    目的 比较GC FU ji IX玻璃离子和银粉玻璃离子充填材料的边缘封闭性.方法 染料法检测两种材料充填离体双尖牙10 d、20 d和30 d后的染料渗透情况,进行统计学分析.结果 10 d和20 d两组比较无统计学差异(P>0.05);30 d比较有统计学差异(P<0.05),GC FU ji IX玻璃离子的边缘封闭性好于银粉玻璃离子.结论 对于乳牙龋齿及不直接承受抗压部位的恒牙龋齿来说,GC FU ji IX玻璃离子是一种理想的充填材料,值得临床推广使用.

  19. Quercetin induces apoptosis and enhances 5-FU therapeutic efficacy in hepatocellular carcinoma.

    Science.gov (United States)

    Dai, Wei; Gao, Quangen; Qiu, Jianping; Yuan, Jianmao; Wu, Guoliang; Shen, Genhai

    2016-05-01

    Quercetin (Q), a flavonoid compound, which is obtained in variety of fruits, seeds, and vegetables, has been reported to possess many pharmacological properties including cancer-preventive and anticancer effects. However, studies on the anticancer effects and underlying mechanisms of Q in human hepatocellular carcinoma (HCC) are still limited. The present study is conducted to investigate the anticancer efficacy and adjuvant chemotherapy action of Q in HCC. HCC cell lines HepG2 and SMCC-7721 were treated with different concentrations of Q. The antiproliferative effects of Q were measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), and the apoptosis and cell cycle dynamics were assessed by flow cytometry; the expression of apoptosis-associated proteins were evaluated by Western blot and immunohistochemistry staining; the tumor growth in vivo was evaluated in a xenograft mouse model. Our results showed that Q effectively inhibited human HCC cell proliferation and induced apoptosis by upregulating the expression of Bad and Bax and downregulating the expression of Bcl-2 and Survivin in vitro. Furthermore, Q obviously inhibited the tumor growth and enhanced the 5-fluorouracil (5-FU) therapeutic efficacy in vitro and in vivo. Taken together, our findings highlight that Q effectively inhibited the growth of tumor and enhanced the sensitivity to thermotherapy, indicating Q is a potential treatment option for HCC.

  20. V346 Normae: first post-outburst observations of an FU Orionis star

    Science.gov (United States)

    Kraus, S.; Caratti o Garatti, A.; Garcia-Lopez, R.; Kreplin, A.; Aarnio, A.; Monnier, J. D.; Naylor, T.; Weigelt, G.

    2016-10-01

    During their formation phase, stars gain most of their mass in violent episodic accretion events, such as observed in FU Orionis (FUor) and EXor stars. V346 Normae is a well-studied FUor that underwent a strong outburst beginning around 1980. Here, we report on photometric and spectroscopic observations, which show that the visual/near-infrared brightness has decreased dramatically between the 1990s and 2010 (ΔR ≈ 10.9 mag, ΔJ ≈ 7.8 mag and ΔK ≈ 5.8 mag). The spectral properties of this fading event cannot be explained by variable extinction alone, but indicate a drop in accretion rate by two to three orders of magnitude. This is the first time that a member of the FUor class has been observed to switch to a very low accretion phase. Remarkably, in the last few years (2011-2015) V346 Nor has brightened again at all near-infrared wavelengths, indicating the onset of a new outburst event. The observed behaviour might be consistent with the clustered luminosity bursts that have been predicted by recent gravitational instability and fragmentation models for the early stages of protostellar evolution. Given V346 Nor's unique characteristics (concerning outburst duration, repetition frequency and spectroscopic diagnostics), our results also highlight the need to revisit the FUor/EXor classification scheme.

  1. Kung fu training improves physical fitness measures in overweight/obese adolescents: the "martial fitness" study.

    Science.gov (United States)

    Tsang, Tracey W; Kohn, Michael R; Chow, Chin Moi; Fiatarone Singh, Maria Antoinette

    2010-01-01

    Aim. To examine the efficacy of a six-month Kung Fu (KF) program on physical fitness in overweight/obese adolescents. Methods. Subjects were randomly assigned to the KF or sham exercise (Tai Chi, TC) control group. Physical measurements in cardiovascular fitness and muscle fitness occurred at baseline and after 6 months of training thrice weekly. Results. Twenty subjects were recruited. One subject was lost to follow-up, although overall compliance to the training sessions was 46.7 +/- 27.8%. At follow-up, the cohort improved in absolute upper (P = .002) and lower (P = .04) body strength, and upper body muscle endurance (P = .02), without group differences. KF training resulted in significantly greater improvements in submaximal cardiovascular fitness (P = .03), lower body muscle endurance (P = .28; significant 95% CI: 0.37-2.49), and upper body muscle velocity (P = .03) relative to TC training. Conclusions. This short-term KF program improved submaximal cardiovascular fitness, lower body muscle endurance, and muscle velocity, in overweight/obese adolescents with very low baseline fitness.

  2. Electromiographic and kinematic characteristics of Kung Fu Yau-Man palm strike.

    Science.gov (United States)

    Neto, O P; Magini, Marcio

    2008-12-01

    A kinematic and electromyographic analysis of Kung Fu (KF) Yau-Man palm strikes without impact is presented. An empirical model applied to data obtained by a high-speed camera describes the kinematic characteristics of the movement. The electromyographic patterns of the biceps brachii, brachioradialis and triceps brachii muscles were studied during the strike in the time (root mean square) and frequency (wavelet transform) domains. Eight KF practitioners participated in the investigation. A wooden board was placed in front of the subjects, and they were asked to perform the strike imagining a target above the board. The results show that the Yau-Man KF palm strike has very similar kinematic characteristics to a simple moderate speed elbow extension movement. All practitioners positioned themselves in relation to the wooden board in a way to achieve their highest hand speeds in the instant their hands crossed the board. The analyses of the electromyography data shows a well developed muscle coordination of the practitioners in agreement with kinematic results. The results of this paper are important not only for improving the performance of practitioners but also to demonstrate the applicability of KF in the process of motor control development.

  3. Layered inorganic nanocomposites: a promising carrier for 5-fluorouracil (5-FU).

    Science.gov (United States)

    Kevadiya, Bhavesh D; Patel, Tapan A; Jhala, Devendrasinh D; Thumbar, Rahul P; Brahmbhatt, Harshad; Pandya, Maharshi P; Rajkumar, Shalini; Jena, Prasant K; Joshi, Ghanshyam V; Gadhia, Pankaj K; Tripathi, C B; Bajaj, Hari C

    2012-05-01

    We report here the intercalation of 5-fluorouracil (5-FU), an anticancer drug in interlayer gallery of Na(+) clay (Montmorillonite, MMT), with the assistance of biopolymer (chitosan, CS). The X-ray diffraction patterns, thermal and spectroscopic analyses indicated the drug intercalation into the clay interlayer space in support of CS and stabilized in the longitudinal monolayer by electrostatic interaction. In vitro drug release showed controlled release pattern. The genotoxic effect of drug was in vitro evaluated in human lymphocyte cell culture by comet assay, and results indicated significant reduction in DNA damage when drug was intercalated with clay and formulated in composites. The results of in vitro cell viability assay in cancer cells pointed at decreased toxicity of drug when encapsulated in Na(+)-clay plates than the pristine drug. In vivo pharmacokinetics, biodistribution, hepatotoxicity markers, e.g., SGPT and SGOT, and liver/testicular histology in rats showed plasma/tissue drug levels were within therapeutic window as compared to pristine drug. Therefore, drug-clay hybrid and composites can be of considerable value in chemotherapy of cancer with reduced side effects.

  4. Concomitant chemoradiotherapy with CDDP and 5FU for nasopharyngeal carcinoma. The initial evaluation and side effects

    Energy Technology Data Exchange (ETDEWEB)

    Takeuchi, Yousuke; Suzuki, Haruhiko; Shigehara, Takeo; Omura, Ken; Shimada, Fumiyuki; Hatano, Kazuo; Sekiya, Yuichi; Togawa, Takashi [Chiba Cancer Center Hospital (Japan)

    1998-03-01

    Concomitant chemoradiotherapy with CDDP and 5FU was given to 18 patients with nasopharyngeal carcinoma during January 1994-October 1996. One and 17 were in Stages III-IV respectively. None had distant metastasis. The median duration of follow-up of all patients was 23.5 months (6-45). Objective response (CR+PR) of the primary lesion and the regional nodes was 18/18 (100%), whereas CR was 2/18 (11%). CR+PR and CR at the primary lesion were 18/18 (100%) and 5/18 (28%) respectively. Two patients died of disease at T site. One patient was alive with disease. The remaining 15 (83%) patients were relapse free alive. There were 2 relapses, 1 at T+M, and 1 at T+N sites. Side effects, especially myelosuppression and mucositis, were severe. Leukopenia and mucositis in grade 3-4 were 78% and 89% respectively. In conclusion, this regimen has been effective in short term follow-up. However, because of severe side effects, further modifications are required. Long term follow-up are required to define final effectiveness of this regimen. (author)

  5. EL MORFEMA -FU DEL MAPUDUNGUN: LA CODIFICACIÓN GRAMATICAL DEL ANTIPERFECTO

    Directory of Open Access Journals (Sweden)

    Guillermo Soto

    2015-07-01

    Full Text Available El perfecto es un aspecto de perspectiva retrospectiva que codifica la vigencia en el momento de habla de una eventualidad anterior. El presente trabajo propone la existencia de una categoría semántica y gramatical de antiperfecto que, en contraste con el perfecto, codifica la no vigencia en el momento de habla de una eventualidad pasada. Debido a que, al igual que el perfecto, el antiperfecto es sensible a la vigencia de una eventualidad anterior en el momento de habla, proponemos que se trata de un segundo tipo de aspecto de perspectiva retrospectiva. Tras revisar las nociones de perfecto en Comrie (1976, Dik (1997 y Nishiyama y Koenig (2010 y la noción de pasado discontinuo en Plungian y Van der Auwera (2006, se observa el modo en que la categoría propuesta se realiza, codificada gramaticalmente, en la lengua mapuche, mediante el morfema -fu, con especial énfasis en su caracterización semántico-pragmática, su relación con la aktionsart y el papel del contexto en su interpretación.

  6. TraditionalChinesemedicineKangXian Fu FangⅠis effective for prophylaxis and treatmentofalcoholicliverdiseaseinrats

    Institute of Scientific and Technical Information of China (English)

    Xiao-Hui Lv; Li-Ping Zhou; Dong-Ping Liu; Ying Wang; Bing-Yuan Wang; Bao-Yu Fu; Min Song; Chun-Rong Liu

    2007-01-01

    BACKGROUND:Reversal of liver ifbrosis is one of the key steps in the prevention and treatment of alcoholic liver disease (ALD), but the mechanism is unknown. This study was to investigate the effects of the Chinese medicine Kang Xian Fu Fang Ⅰ (KXⅠ) on prophylaxis and treatment of ALD in rats and its possible mechanism of action. METHODS: Eighty male Wistar rats were randomly divided into four groups: normal control; ALD model;treatment of ALD with KXⅠ; and prophylaxis of ALD by KXⅠ. At the end of 4, 8, 12 and 16 weeks, ifve rats from each group were anesthetized and their livers were removed for pathological studies using hematoxylin-eosin and Masson stain, immunohistochemical studies, and lfow cytometry for matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9). Blood samples were taken for hyaluronic acid (HA) assay. RESULTS: Serum HA level and liver collagen content were lower in the groups given KXⅠfor prophylaxis and treatment than in ALD model group (P CONCLUSIONS:KXⅠcan effectively inhibit or reverse the course of ALD. This may be attributable to its capacity to inhibit the expression of MMP-2 and MMP-9.

  7. Optimization of LDL targeted nanostructured lipid carriers of 5-FU by a full factorial design

    Directory of Open Access Journals (Sweden)

    Sare Andalib

    2012-01-01

    Full Text Available Background: Nanostructured lipid carriers (NLC are a mixture of solid and liquid lipids or oils as colloidal carrier systems that lead to an imperfect matrix structure with high ability for loading water soluble drugs. The aim of this study was to find the best proportion of liquid and solid lipids of different types for optimization of the production of LDL targeted NLCs used in carrying 5-Fu by the emulsification-solvent evaporation method. Materials and Methods: The influence of the lipid type, cholesterol or cholesteryl stearate for targeting LDL receptors, oil type (oleic acid or octanol, lipid and oil% on particle size, surface charge, drug loading efficiency, and drug released percent from the NLCs were studied by a full factorial design. Results: The NLCs prepared by 54.5% cholesterol and 25% of oleic acid, showed optimum results with particle size of 105.8 nm, relatively high zeta potential of −25 mV, drug loading efficiency of 38% and release efficiency of about 40%. Scanning electron microscopy of nanoparticles confirmed the results of dynamic light scattering method used in measuring the particle size of NLCs. Conclusions: The optimization method by a full factorial statistical design is a useful optimization method for production of nanostructured lipid carriers.

  8. Multi-Model Grand Ensemble Hydrologic Forecasting in the Fu River Basin Using Bayesian Model Averaging

    Directory of Open Access Journals (Sweden)

    Bo Qu

    2017-01-01

    Full Text Available Statistical post-processing for multi-model grand ensemble (GE hydrologic predictions is necessary, in order to achieve more accurate and reliable probabilistic forecasts. This paper presents a case study which applies Bayesian model averaging (BMA to statistically post-process raw GE runoff forecasts in the Fu River basin in China, at lead times ranging from 6 to 120 h. The raw forecasts were generated by running the Xinanjiang hydrologic model with ensemble forecasts (164 forecast members, using seven different “THORPEX Interactive Grand Global Ensemble” (TIGGE weather centres as forcing inputs. Some measures, such as data transformation and high-dimensional optimization, were included in the experiment after considering the practical water regime and data conditions. The results indicate that the BMA post-processing method is capable of improving the performance of raw GE runoff forecasts, yielding more calibrated and sharp predictive probability density functions (PDFs, over a range of lead times from 24 to 120 h. The analysis of percentile forecasts in two different flood events illustrates the great potential and prospects of BMA GE probabilistic river discharge forecasts, for taking precautions against severe flooding events.

  9. Chondroprotective Effects and Multitarget Mechanisms of Fu Yuan Capsule in a Rat Osteoarthritis Model

    Science.gov (United States)

    Zeng, Li; Xiao, Cai Zhi; Deng, Zi Ting

    2017-01-01

    Fu Yuan Capsule (FYC) has been clinically used for osteoarthritis (OA) and its related diseases for many years in China. However, its pharmacological mechanism remains unclear. This study aimed to investigate the potential chondroprotective effects of FYC on articular cartilage. Rat OA model was induced by anterior cruciate ligament transection. A group of rats was treated with FYC for 12 weeks. Joint structure, types I and II collagen, and proteoglycan were evaluated by histological examination. The expression of C-terminal crosslinking telopeptide of type II collagen, hydroxyproline, a disintegrin and metalloproteinase with thrombospondin motifs, matrix metalloproteinase, interleukin-1 beta, nitric oxide, prostaglandin E2, heat-shock protein 70, transforming growth factor-beta, osteoprotegerin, and receptor activator of nuclear factor κB ligand were detected. Treatment with FYC could protect against articular cartilage injury. FYC treatment significantly decreased the extracellular matrix degradation factors and inflammatory mediators. Moreover, articular cartilage protective factors were increased in the FYC group. The current finding suggests that FYC protects articular cartilage in a rat OA model through various ways. Thus, it may be an effective agent for OA treatment. PMID:28167976

  10. SED analysis of class I and class II FU Orionis stars

    CERN Document Server

    Gramajo, Luciana V; Gómez, Mercedes

    2014-01-01

    FU Orionis stars (FUORS) are eruptive pre-main sequence objects thought to represent quasi-periodic or recurring stages of enhanced accretion during the low-mass star-forming process. We characterize the sample of known and candidate FUORS in an homogeneous and consistent way, deriving stellar and circumstellar parameters for each object. We emphasize the analysis in those parameters that are supposed to vary during the FUORS stage. We modeled the SEDs of 24 of the 26 currently known FUORS, using the radiative transfer code of Whitney et al (2003b). We compare our models with those obtained by Robitaille et al. (2007) for Taurus class II and I sources in quiescence periods, by calculating the cumulative distribution of the different parameters. FUORS have more massive disks: we find that $\\sim80\\%$ of the disks in FUORS are more massive than any Taurus class II and I sources in the sample. Median values for the disk mass accretion rates are ~ 1.e-7 Msun/yr vs ~ 1.e-5 Msun/yr for standard YSOs (young stellar o...

  11. V346 Normae: First post-outburst observations of an FU Orionis star

    CERN Document Server

    Kraus, Stefan; Garcia-Lopez, Rebeca; Kreplin, Alexander; Aarnio, Alicia; Monnier, John D; Naylor, Tim; Weigelt, Gerd

    2016-01-01

    During their formation phase stars gain most of their mass in violent episodic accretion events, such as observed in FU Orionis (FUor) and EXor stars. V346 Normae is a well-studied FUor that underwent a strong outburst beginning in $\\sim1980$. Here, we report photometric and spectroscopic observations which show that the visual/near-infrared brightness has decreased dramatically between the 1990s and 2010 (${\\Delta}R\\approx10.9^{\\rm m}$, ${\\Delta}J\\approx7.8^{\\rm m}$, ${\\Delta}K\\approx5.8^{\\rm m}$). The spectral properties of this fading event cannot be explained with variable extinction alone, but indicate a drop in accretion rate by 2-3 orders of magnitude, marking the first time that a member of the FUor class has been observed to switch to a very low accretion phase. Remarkably, in the last few years (2011-2015) V346 Nor has brightened again at all near-infrared wavelengths, indicating the onset of a new outburst event. The observed behaviour might be consistent with the clustered luminosity bursts that h...

  12. Jin Fu Kang Oral Liquid Inhibits Lymphatic Endothelial Cells Formation and Migration

    Directory of Open Access Journals (Sweden)

    Hai-Lang He

    2016-01-01

    Full Text Available Lung cancer is the leading cause of cancer-related deaths worldwide. Jin Fu Kang (JFK, an oral liquid prescription of Chinese herbal drugs, has been clinically available for the treatment of non-small cell lung cancer (NSCLC. Lymphangiogenesis is a primary event in the process of cancer development and metastasis, and the formation and migration of lymphatic endothelial cells (LECs play a key role in the lymphangiogenesis. To assess the activity of stromal cell-derived factor-1 (SDF-1 and the coeffect of SDF-1 and vascular endothelial growth factor-C (VEGF-C on the formation and migration of LECs and clarify the inhibitory effects of JFK on the LECs, the LECs were differentiated from CD34+/VEGFR-3+ endothelial progenitor cells (EPCs, and JFK-containing serums were prepared from rats. SDF-1 and VEGF-C both induced the differentiation of CD34+/VEGFR-3+ EPCs towards LECs and enhanced the LECs migration. Couse of SDF-1 and VEGF-C displayed an additive effect on the LECs formation but not on their migration. JFK inhibited the formation and migration of LECs, and the inhibitory effects were most probably via regulation of the SDF-1/CXCR4 and VEGF-C/VEGFR-3 axes. The current finding suggested that JFK might inhibit NSCLC through antilymphangiogenesis and also provided a potential to discover antilymphangiogenesis agents from natural resources.

  13. FU Orionis outbursts, preferential recondensation of water ice, and the formation of giant planets

    Science.gov (United States)

    Hubbard, Alexander

    2017-02-01

    Ices, including water ice, prefer to recondense on to preexisting nuclei rather than spontaneously forming grains from a cloud of vapour. Interestingly, different potential recondensation nuclei have very different propensities to actually nucleate water ice at the temperatures associated with freeze-out in protoplanetary discs. Therefore, if a region in a disc is warmed and then recooled, water vapour should not be expected to refreeze evenly on to all available grains. Instead, it will preferentially recondense on to the most favorable grains. When the recooling is slow enough, only the most favorable grains will nucleate ice, allowing them to recondense thick ice mantles. We quantify the conditions for preferential recondensation to rapidly create pebble-sized grains in protoplanetary discs and show that FU Orionis type outbursts have the appropriate cooling rates to drive pebble creation in a band about 5 au wide outside of the quiescent frost line from approximately Jupiter's orbit to Saturn's (about -10 au). Those pebbles could be of the appropriate size to proceed to planetesimal formation via the Streaming Instability, or to contribute to the growth of planetesimals through pebble accretion. We suggest that this phenomenon contributed to the formation of the gas giants in our own Solar system.

  14. General description and first results with the ORIS-LMRI 4 {pi} {gamma} metering chamber; Descripcion general y primeros resultados con la camara 4 {pi} {gamma} metrologica ORIS-LMRI

    Energy Technology Data Exchange (ETDEWEB)

    Tejera R, A.; Becerril V, A.; Cortes P, A

    1990-04-15

    A problem that present the ionization chambers is that the response for the radiation is global, that is to say that it cannot discriminate against selectively the relating responses at different energies, if these impact simultaneously in the active volume. This is a reason to calibrate the chambers, if is possible, with gamma monoenergetic emitting and by average calculations to complete the response curve with gamma emitting of well-known yields. To obtain the calibration coefficients and may used them, it is necessary that so much the standardized radioisotopes as the solutions by calibrating, are contained in vessels with the same geometry and the same quantity. In the exposed case, pattern solutions of 5 ml were used contained in glass cruets of 10 ml. The problem solutions are contained in same cruets to those of the patterns. The first results obtained with the ORIS-LMRI 4 {pi} {gamma} metering chamber are presented. (Author)

  15. Investigation on biochemical compositional changes during the microbial fermentation process of Fu brick tea by LC-MS based metabolomics.

    Science.gov (United States)

    Xu, Jie; Hu, Feng-Lin; Wang, Wei; Wan, Xiao-Chun; Bao, Guan-Hu

    2015-11-01

    Fu brick tea (FBT) is a unique post-fermented tea product which is fermented with fungi during the manufacturing process. In this study, we investigated the biochemical compositional changes occurring during the microbial fermentation process (MFP) of FBT based on non-targeted LC-MS, which was a comprehensive and unbiased methodology. Our data analysis took a two-phase approach: (1) comparison of FBT with other tea products using PCA analysis to exhibit the characteristic effect of MFP on the formation of Fu brick tea and (2) comparison of tea samples throughout the MFP of FBT to elucidate the possible key metabolic pathways produced by the fungi. Non-targeted LC-MS analysis clearly distinguished FBT with other tea samples and highlighted some interesting metabolic pathways during the MFP including B ring fission catechin. Our study demonstrated that those fungi had a significant influence on the biochemical profiles in the FBT and consequently contributed to its unique quality.

  16. Enteric coated HPMC capsules plugged with 5-FU loaded microsponges: a potential approach for treatment of colon cancer

    Directory of Open Access Journals (Sweden)

    Ankita Gupta

    2015-09-01

    Full Text Available The work was aimed at developing novel enteric coated HPMC capsules (ECHC plugged with 5 Florouracil (5-FU loaded Microsponges in combination with calcium pectinate beads. Modified quasi-emulsion solvent diffusion method was used to formulate microsponges based on 32 factorial design and the effects of independent variables (volume of organic solvent and Eudragit RS100 content on the dependent variables (Particle size, %EE & % CDR were determined. The optimized microsponges (F4 were characterized by SEM, PXRD, TGA and were plugged along with calcium pectinate beads in HPMC capsules and the HPMC capsules were further coated with enteric polymer Eudragit L 100 (Ed-L100 and/ or Eudrgit S 100 (Ed-S 100 in different proportions. In vitro release study of ECHC was performed in various release media sequentially SGF for 2 h, followed by SIF for the next 6 h and then in SCF (in the presence and absence of pectinase enzyme for further 16 h. Drug release was retarded on coating with EdS-100 in comparison to blend of EdS-100: EdL-100 coating. The percentage of 5-FU released at the end of 24 h from ECHC 3 was 97.83 ± 0.12% in the presence of pectinase whereas in control study it was 40.08 ± 0.02% drug. The optimized formulation was subjected to in vivo Roentgenographic studies in New Zealand white rabbits to analyze the in vivo behavior of the developed colon targeted capsules. Pharmacokinetic studies in New Zealand white rabbits were conducted to determine the extent of systemic exposure provided by the developed formulation in comparison to 5-FU aqueous solutions. Thus, enteric coated HPMC capsules plugged with 5-FU loaded microsponges and calcium pectinate beads proved to be promising dosage form for colon targeted drug delivery to treat colorectal cancer.

  17. Oriënterende meting van ammoniakemissie Holcim Sleufvloer type B = Explorative ammonia emission measurements on the Holcim grooved floor type B

    NARCIS (Netherlands)

    Dooren, van H.J.C.; Blanken, K.; Gunnink, H.; Huis in 't Veld, J.W.H.

    2010-01-01

    Dit rapport beschrijft de flux kamer metingen die uitgevoerd zijn aan de Holcim Sleufvloer Type B vergeleken met de sleufvloer type A en een standaard betonnen roostervloer als referentie. De ammoniakemissie bedroeg 39% van de emissie die op de roostervloer gemeten is. Het betreft hier oriënterende

  18. U–Pb zircon and biostratigraphic data of high‐pressure/ low‐temperature metamorphic rocks of the Talea Ori : tracking the Paleotethys suture in central Crete, Greece

    NARCIS (Netherlands)

    Zulauf, G.; Dörr, W.; Krahl, J.; Lahaye, Y.; Chatzaras, V.; Xypolias, P.

    2016-01-01

    Inherited deformation microfabrics of detrital quartz grains and U–Pb (Laser ablation (LA)-ICPMS and ID TIMS) ages of detrital zircons separated from the Phyllite–Quartzite Unit s.l. of the Talea Ori, central Crete, suggest strikingly different source rocks. Albite gneiss of the lower Rogdia Beds in

  19. Combined MTX{center_dot}5-FU{center_dot}CDGP for the treatment of head and neck cancer

    Energy Technology Data Exchange (ETDEWEB)

    Sakoda, Takema; Kitano, Hiroya [Tottori Univ., Yonago (Japan). Faculty of Medicine; Saitoh, Yuko; Ikeda, Hiroki; Dake, Yoshihiro; Enomoto, Tadao [Japanese Red Cross Society Wakayama Medical Center (Japan); Seno, Satoshi [Shiga Univ. of Medical Science, Otsu (Japan); Kawano, Atsushi [Tokyo Medical Coll. (Japan)

    2003-05-01

    Combination chemotherapy including 5-fluorouracil (5-FU) and nedaplatin (CDGP) with methotrexate (MTX) and leucovorin (LV) was administered for modulation in patients with head and neck cancer. We treated 19 patients with MTX{center_dot}5-FU{center_dot}CDGP consisting of 150 mg/body of MTX on day 1 followed by a 3-day continuous infusion of 5-FU at 3,500 mg/m{sup 2} and 17 injections of LV at 15 mg and infusion of CDGP at 100 mg/m{sup 2}. Six patients had recurrent head and neck cancer, and 13 had newly diagnosed disease. Eleven of the new patients were concurrently treated with radiation therapy. Treatment-associated toxicity was significant, including mucositis and myelosuppression, but acceptable. Sixteen patients were eligible for evaluation of response. The overall complete response rate was 75.0% (12/16). Patients treated with radiotherapy had a 90.0% (9/10) overall complete response rate. (author)

  20. Proliferation rate but not mismatch repair affects the long-term response of colon carcinoma cells to 5FU treatment.

    Science.gov (United States)

    Choudhary, B; Hanski, M L; Zeitz, M; Hanski, C

    2012-07-01

    The role of mismatch repair (MMR) in the response of colon carcinoma cells to 5-fluorouracil (5FU) is not well understood. In most of the in vitro studies only short-term response was investigated. We focussed here on the influence of MMR status on the mechanism of the short- and long-term response to clinically relevant 5FU concentrations by using isogenic or semiisogenic cell line pairs expressing/nonexpressing the hMLH1 protein, an important component of the MMR system. We show that the lower survival of MMR-proficient than of MMR-deficient cells in the clonogenic survival assay is due to a more frequent early cell arrest and to subsequent senescence. By contrast, the long-term cell growth after treatment, which is also affected by long-term arrest and senescence, is independent from the MMR status. The overall effect on the long-term cell growth is a cumulative result of cell proliferation rate-dependent growth inhibition, apoptosis and necrotic cell death. The main long-term cytotoxic effect of 5FU is the inhibition of growth while apoptosis and the necrotic cell death are minor contributions.

  1. Adverse immunoregulatory effects of 5FU and CPT11 chemotherapy on myeloid-derived suppressor cells and colorectal cancer outcomes.

    Science.gov (United States)

    Kanterman, Julia; Sade-Feldman, Moshe; Biton, Moshe; Ish-Shalom, Eliran; Lasry, Audrey; Goldshtein, Aviya; Hubert, Ayala; Baniyash, Michal

    2014-11-01

    Colorectal cancer is associated with chronic inflammation and immunosuppression mediated by myeloid-derived suppressor cells (MDSC). Although chemotherapy reduces tumor burden at early stages, it tends to have limited effect on a progressive disease, possibly due to adverse effects on the immune system in dictating disease outcome. Here, we show that patients with advanced colorectal cancer display enhanced MDSC levels and reduced CD247 expression and that some conventional colorectal cancer chemotherapy supports the immunosuppressive tumor microenvironment. A FOLFOX combined therapy reduced immunosuppression, whereas a FOLFIRI combined therapy enhanced immunosuppression. Mechanistic studies in a colorectal cancer mouse model revealed that FOLFIRI-like therapy including the drugs CPT11 and 5-fluorouracil (5FU) damaged host immunocompetence in a manner that limits treatment outcomes. CPT11 blocked MDSC apoptosis and myeloid cell differentiation, increasing MDSC immunosuppressive features and mouse mortality. In contrast, 5FU promoted immune recovery and tumor regression. Thus, CPT11 exhibited detrimental immunoregulatory effects that offset 5FU benefits when administered in combination. Our results highlight the importance of developing therapeutic regimens that can target both the immune system and tumor towards improved personalized treatments for colorectal cancer.

  2. Experimental Study on the Mechanism of Protective Effect of Free Fu on Gut-derived Endotoxin-Mediated Lung Damage

    Institute of Scientific and Technical Information of China (English)

    李道本; 杨胜兰; 陈瑞

    2004-01-01

    The effect of tumor necrosis factor-α (TNF-α) on endotoxin (ET)-mediated lung damage caused by incomplete ligation of large intestine and the influence of free Fu on the expression of TNF-α mRNA were explored. Forty SD rats were randomly divided into 4 groups: normal control group, model group, ligation group and treatment group (n=10 in each group). The models were made by the method of partly ligating the rectum outside the body. The plasma level of lipopolysaccaride was measured by dynamic nephelo metric method and the serum level of TNF-α was detected by the method of radioactive immunity. The expression of TNF-α mRNA in lung tissue was detected by RT-PCR method. The results were compared among the 4 groups. The results showed the plasma levels of ET and serum TNF-α in the model group and the expression of TNF-α mRNA in the lung tissues were remarkably higher than those in the normal control group (P<0.01). After the treatment of free Fu, all of the above indexes in the treatment group were all decreased as compared with model group (all P<0.01), and the damage to lung was alleviated. It was concluded that TNF-α might play a very important role in the ET-mediated lung damage caused by incomplete ligation of large intestine, free Fu could protect the lung from damage.

  3. Utilisation de la théorie de possibilités pour calculer un indicateur agri-environnemental

    OpenAIRE

    Assaghir, Zainab; Girardin, Philippe; Napoli, Amedeo

    2008-01-01

    National audience; Les indicateurs développés et utilisés en agronomie sont généralement calculés a partir de données de nature imparfaite. Les sources fournissent de l'information a propos d'une quantité mal connue. Dans cet article, nous étudions une méthode de fusion fondée sur la théorie des possibilités et la notion de sous-ensembles maximaux cohérents pour calculer un indicateur agri-environnemental estimant le risque des pratiques phytosanitaires sur les eaux souterraines. Il s'agit de...

  4. A biomechanical modeling study of the effects of the orbicularis oris muscle and jaw posture on lip shape

    CERN Document Server

    Stavness, Ian; Perrier, Pascal; Demolin, Didier; Payan, Yohan

    2013-01-01

    Purpose: The authors' general aim is to use biomechanical models of speech articulators to explore how possible variations in anatomical structure contribute to differences in articulatory strategies and phone systems across human populations. Specifically, they investigated 2 issues: (a) the link between lip muscle anatomy and variability in lip gestures and (b) the constraints of coupled lip/jaw biomechanics on jaw posture in labial sounds. Method: The authors used a model coupling the jaw, tongue, and face. First, the influence of the orbicularis oris (OO) anatomical implementation was analyzed by assessing how changes in depth (from epidermis to the skull) and peripheralness (proximity to the lip horn center) affected lip shaping. Second, the capability of the lip/jaw system to generate protrusion and rounding, or labial closure, was evaluated for different jaw heights. Results: Results showed that a peripheral and moderately deep OO implementation is most appropriate for protrusion and rounding; a superf...

  5. Théorie de l’évolution et démographie : une histoire malheureuse

    OpenAIRE

    Harpending, Henry

    2014-01-01

    Introduction Très peu de gens doutent que les êtres humains soient issus du processus d’évolution darwinienne qui a engendré la diversité de la vie terrestre. L’évolution est le point d’ancrage de toute théorie en biologie, c’est un domaine de recherche actif et beaucoup est à présent connu sur les lois et les mécanismes de l’évolution. On comprend la stratégie reproductive des saumons, la taille de la portée chez les lézards, le dimorphisme sexuel des poissons et des orangs-outans, mais les ...

  6. Planetary influence in the gap of a protoplanetary disk: structure formation and an application to V1247 Ori

    Science.gov (United States)

    Alvarez-Meraz, R.; Nagel, E.; Rendon, F.; Barragan, O.

    2017-10-01

    We present a set of hydrodynamical models of a planetary system embedded in a protoplanetary disk in order to extract the number of dust structures formed in the disk, their masses and sizes, within optical depth ranges τ≤0.5, 0.5an increase in the number of planets implies an increase in the creation rate of massive structures; (2) a lower planetary mass accretion corresponds to slower time effects for optically thin structures; (3) an increase in the number of planets allows a faster evolution of the structures in the Hill radius for the different optical depth ranges of the inner planets. An ad-hoc simulation was run using the available information of the stellar system V1247 Ori, leading to a model of a planetary system which explains the SED and is consistent with interferometric observations of structures.

  7. Honneth Axel, La réification. Petit traité de Théorie critique

    Directory of Open Access Journals (Sweden)

    Nicolas Marquis

    2011-03-01

    Full Text Available Le dernier ouvrage d’Honneth est ambitieux et annonce, comme son titre l’indique, un traité de théorie critique, aussi petit soit-il. On le sait, la volonté d’Honneth est de procéder à une réactualisation de l’héritage laissé par les générations successives qui ont fait et font encore l’École de Francfort. Prenant acte d’un décalage de contexte entre les époques de Lukacs, d’Adorno, d’Horkheimer et de Marcuse, pour ne citer qu’eux, et la nôtre, Honneth redouble d’efforts ces derniers temps po...

  8. Françoise Lavocat (a cura di La théorie littéraire des mondes possibles

    Directory of Open Access Journals (Sweden)

    Guido Furci

    2012-04-01

    Full Text Available I testi raccolti ed introdotti da Françoise Lavocat nel suo La théorie littéraire des mondes possibile (2010 ambiscono tutti a colmare una lacuna. Quella causata dal cosiddetto tournant cognitiviste, caratterizzato dal consolidarsi di un dialogo fra scienze umane e scienze esatte – nell’intento, certo, di ridurre lo scarto fra ambiti disciplinari distinti, seppur accomunati da uno stesso interesse per il lascito post-strutturalista –, ma anche promotore di una politica editoriale senza precedenti, destinata ad escludere dal canone contemporaneo buona parte di quei contributi, il cui punto di forza non potesse consistere nell’ulteriore avanzamento della rivoluzione epistemologica in corso.

  9. Les ethnothéories de l'éducation, quel accord entre parents migrants et enseignantes?

    OpenAIRE

    Conus, Xavier; Ogay, Tania

    2015-01-01

    International audience; En prologue à une recherche portant sur la construction de la relation familles-école au moment de l'entrée à l'école, nous présentons ici les résultats d'une recherche préliminaire, descriptive et quantitative, dont l'objectif est de comparer parents migrants et enseignants du point de vue de leurs conceptions (ou " ethnothéories " selon le modèle de la niche développementale) de l'éducation et du développement de l'enfant. L'enquête a été réalisée au moyen d'un quest...

  10. Period studies of classical Algol-type binaries II: UX Leo, RW Mon, EQ Ori, XZ UMa and AX Vul

    Science.gov (United States)

    Soydugan, F.; Erdem, A.; Doğru, S. S.; Aliçavuş, F.; Soydugan, E.; Çiçek, C.; Demircan, O.

    2011-07-01

    This study presents an investigation of the orbital period variations of five Algol type binaries, UX Leo, RW Mon, EQ Ori, XZ UMa and AX Vul based on all available minima times. The O- C diagrams of all systems exhibit a periodic variation superimposed on a downward parabolic segment. The mass loss due to magnetic braking effect in the cooler components is assumed to account for the parabolic variation with a downward shape, while it is suggested that the light-time effect (LITE) due to an unseen component around the eclipsing binaries explains the tilted sinusoidal changes in their O- C diagrams. The orbital period decrease rates for the systems are estimated as approximately between about 0.7 and 2.5 s per century. It is clearly seen that mass loss effect is more dominant than the expected mass transfer for classical Algols in this study. The minimum mass of the probable third bodies around the eclipsing pairs was calculated to be ⩽0.5 M ⊙ except for UX Leo, in which it was estimated to be approximately 0.9 M ⊙. In order to search for third lights in the light curves of five systems, the V-light curves of the systems were analyzed and their physical and photometric parameters were determined. For UX Leo, a significant third light contribution was determined. We found a very small third light that can be tested using multi-color light curves, for RW Mon, EQ Ori and XZ UMa, while a third light for AX Vul could not be exposed.

  11. The fluid and electrolyte balance of New Zealand European and Māori/Pacific Island athletes: An observational study.

    Science.gov (United States)

    McLean, Andrew; Brown, Rachel Clare; Black, Katherine Elizabeth

    2016-01-01

    Observational research on professional athletes from the USA suggests differences may exist in sweat sodium loss based on ethnic differences. The New Zealand (NZ) sporting population is mainly of European or Māori/Pacific Island origin. Therefore, this study aimed to describe the fluid-electrolyte balance of athletes by ethnicity. A total of 20 Māori/Pacific Islanders (MP; body mass 100.97 ± 13.05 kg) and 29 NZ European (NZE; body mass 89.11 ± 11.56 kg) elite male athletes were recruited. Sweat rates were determined by body mass change during a 1-h spin cycle exercise session, during which fluid intakes and heart rate were recorded. Sweat samples were analysed for sodium concentration. Mean ± SD sweat sodium concentrations were 73.4 ± 27.2 mmol·L(-1) and 55.5 ± 26.8 mmol·L(-1) for the MP and NZE groups, respectively (p = 0.070). Sweat rate was 0.93 ± 0.26 L·h(-1) for the MP group and 0.89 ± 0.33 L·h(-1) for the NZE group (p = 0.357). Fluid intake was 1.05 ± 0.48 L and 0.93 ± 0.49 L for MP and NZE, respectively (p = 0.395). Half of the MP group gained weight during the exercise session compared to 37% of the NZE group. Pre-exercise urine specific gravity was significantly lower amongst the NZE group (1.016 ± 0.009 g mL(-1)) than the MP group (1.024 ± 0.008 g mL(-1)) p = 0.001. There was no significant difference in heart rate between the groups, p = 0.082. Hydration practices of athletes in NZ may differ by ethnicity, and this may highlight the need for more targeted education by ethnicity.

  12. Pharmacoeconomic analysis of adjuvant oral capecitabine vs intravenous 5-FU/LV in Dukes' C colon cancer: the X-ACT trial

    Science.gov (United States)

    Cassidy, J; Douillard, J-Y; Twelves, C; McKendrick, J J; Scheithauer, W; Bustová, I; Johnston, P G; Lesniewski-Kmak, K; Jelic, S; Fountzilas, G; Coxon, F; Díaz-Rubio, E; Maughan, T S; Malzyner, A; Bertetto, O; Beham, A; Figer, A; Dufour, P; Patel, K K; Cowell, W; Garrison, L P

    2006-01-01

    Oral capecitabine (Xeloda®) is an effective drug with favourable safety in adjuvant and metastatic colorectal cancer. Oxaliplatin-based therapy is becoming standard for Dukes' C colon cancer in patients suitable for combination therapy, but is not yet approved by the UK National Institute for Health and Clinical Excellence (NICE) in the adjuvant setting. Adjuvant capecitabine is at least as effective as 5-fluorouracil/leucovorin (5-FU/LV), with significant superiority in relapse-free survival and a trend towards improved disease-free and overall survival. We assessed the cost-effectiveness of adjuvant capecitabine from payer (UK National Health Service (NHS)) and societal perspectives. We used clinical trial data and published sources to estimate incremental direct and societal costs and gains in quality-adjusted life months (QALMs). Acquisition costs were higher for capecitabine than 5-FU/LV, but higher 5-FU/LV administration costs resulted in 57% lower chemotherapy costs for capecitabine. Capecitabine vs 5-FU/LV-associated adverse events required fewer medications and hospitalisations (cost savings £3653). Societal costs, including patient travel/time costs, were reduced by >75% with capecitabine vs 5-FU/LV (cost savings £1318), with lifetime gain in QALMs of 9 months. Medical resource utilisation is significantly decreased with capecitabine vs 5-FU/LV, with cost savings to the NHS and society. Capecitabine is also projected to increase life expectancy vs 5-FU/LV. Cost savings and better outcomes make capecitabine a preferred adjuvant therapy for Dukes' C colon cancer. This pharmacoeconomic analysis strongly supports replacing 5-FU/LV with capecitabine in the adjuvant treatment of colon cancer in the UK. PMID:16622438

  13. Synthesis of liver-targeting dual-ligand modified GCGA/5-FU nanoparticles and their characteristics in vitro and in vivo

    Directory of Open Access Journals (Sweden)

    Chen M

    2013-11-01

    Full Text Available Mingrong Cheng,1,2,* Xiaoyan Gao,3,* Yong Wang,4,* Houxiang Chen,5 Bing He,6 Yingchun Li,2 Jiang Han,1 Zhiping Zhang11Department of General Surgery, Pudong New Area District Zhoupu Hospital, Shanghai, People’s Republic of China; 2Department of Endoscopy, 3Department of Plastic Surgery, Pudong New Area District Zhoupu Hospital, Shanghai, People's Republic of China; 4School of Materials Science and Engineering, Wuhan University of Technology, Wuhan, People’s Republic of China; 5Zhejiang Huafon Fiber Research Institute, Zhejiang Huafon Spandex Co, Ltd, Wenzhou, People’s Republic of China; 6Department of General Surgery, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, People's Republic of China *These authors equally contributed to this research Abstract: Nanoparticle drug delivery systems using polymers hold promise for clinical applications. We synthesized dual-ligand modified chitosan (GCGA nanoparticles using lactic acid, glycyrrhetinic acid, and chitosan to target the liver in our previous studies. We then synthesized the GCGA/5-FU nanoparticles by conjugating 5-fluorouracil (5-FU onto the GCGA nanomaterial, which had a mean particle size of 239.9 nm, a polydispersity index of 0.040, a zeta potential of +21.2 mV, and a drug loading of 3.90%. GCGA/5-FU nanoparticles had good slow release properties, and the release process could be divided into five phases: small burst release, gentle release, second burst release, steady release, and slow release. Inhibitory effects of GCGA/5-FU on tumor cells targeted the liver, and were time and dose dependent. GCGA nanoparticles significantly prolonged the efficacy of 5-FU on tumor cells, and alleviated the resistance of tumor cells to 5-FU. GCGA/5-FU nanoparticles were mostly concentrated in the liver, indicating that the GCGA nanoparticles were liver targeting. GCGA/5-FU nanoparticles significantly suppressed tumor growth in orthotopic liver transplantation mouse model, and improved

  14. Research Progress on 5-FU Derivatives%5-氟尿嘧啶及其衍生物的研究进展

    Institute of Scientific and Technical Information of China (English)

    袁吉; 倪孟祥

    2012-01-01

    5-FU is an antimetabolite, which possesses activity against a wide range of solid tumors. The main mechanism of 5-FU is interfering with DNA synthesis and mRNA translation. However,because of the nonspecific cytotoxicity of 5-FU,the patients display several side effects. Numerous modifications of the 5-FU structure have been performed in order to overcome these disadvantages. In this paper,the mechanism and pharmacokinetics of 5-FU are briefly introduced, then several 5-FU derivatives including oral 5-FU prodrugs are presented ,finally the new innovative methods of increasing bioavailability of 5-FU and derivatives are described. All these will provide the theoretical basis for rational administration.%尿嘧啶的氟化类似物5-FU是一种抗代谢物,它对很多实体肿瘤有较好活性.5-FU抗肿瘤活性是通过干扰DNA合成和mRNA翻译来实现的.然而,由于5-FU具有非特异性细胞毒性,故采用5-FU治疗的患者表现出多种副作用.为了改善这些缺点,研究者们对5-FU的结构展开了大量的修饰工作.文章综述了5-FU的作用机理以及药代动力学情况,介绍了5-FU的几种新型修饰衍生物.最后,对提高5-FU衍生物生物利用度的研究进展进行了综述,为5-FU衍生药物的合理使用提供了理论依据.

  15. Inhibitory effect of sil ibinin combined with 5-FU treatment on mal ignant biological behaviors of gastric cancer cell l ines MGC803%水飞蓟宾联合5-FU 对胃癌细胞株 MGC803恶性生物学行为的抑制作用研究

    Institute of Scientific and Technical Information of China (English)

    王阳; 李昌林

    2016-01-01

    目的::研究水飞蓟宾联合5-FU 处理对胃癌细胞株 MGC803恶性生物学行为的抑制作用.方法:培养胃癌细胞株 MGC803,分为 NC 组、5-Fu 组、SB+5-Fu 组并用不同条件进行处理,检测凋亡细胞数目、侵袭细胞数目以及增殖、侵袭相关基因的表达量.结果:处理后6h、12h、18h、24h 时,5-Fu 组、SB+5-Fu 组凋亡细胞的数目显著多于 NC 组、侵袭数目显著少于 NC 组,SB+5-Fu 组凋亡细胞的数目显著多于5-Fu 组、侵袭数目显著少于5-Fu 组(P <0.05);5-Fu 组、SB+5-Fu 组细胞中 Vav3、PTP1B、GOLPH3、RUNX3、Sipa1、UbcH10、NEDD9、Mig-7、CD157、AEP、Galectin-1的 mRNA 含量低于 NC组(P <0.05);SB+5-Fu 组细胞中 Vav3、PTP1B、GOLPH3、UbcH10、NEDD9、Mig-7、CD157、AEP、Galectin-1的 mRNA 含量低于5-Fu 组(P <0.05),RUNX3、Sipa1的 mRNA 含量与5-Fu 组差异无统计学意义(P >0.05).结论:与5-FU 单药处理相比,水飞蓟宾联合5-FU 处理能够更为有效的促进胃癌细胞凋亡、抑制胃癌细胞侵袭、调节增殖和侵袭相关基因的表达.%Objective:To study the inhibitory effect of silibinin combined with 5-FU treatment on malignant biological behaviors of gastric cancer cell lines MGC803.Methods:Gastric cancer cell lines MGC803 were cultured,divided into NC group,5-Fu group and SB+5-Fu group and treated with different conditions,and then the number of apoptotic cells,the num-ber of invasive cells as well as the expression of proliferation and invasion-related genes were detected.Results:6 h,12 h,18 h and 24 h after treatment,the number of apoptotic cells of 5-Fu group and SB+5-Fu group was significantly more than that of NC group,the number of invasive cells was significantly less than that of NC group,the number of apoptotic cells of SB+5-Fu group was significantly more than that of 5-Fu group,and the number of invasive cells was significantly less than that of 5-Fu group;mRNA contents of Vav3

  16. A tertiary approach to improving equity in health: quantitative analysis of the Māori and Pacific Admission Scheme (MAPAS) process, 2008-2012.

    Science.gov (United States)

    Curtis, Elana; Wikaire, Erena; Jiang, Yannan; McMillan, Louise; Loto, Rob; Airini; Reid, Papaarangi

    2015-01-20

    Achieving health equity for indigenous and ethnic minority populations requires the development of an ethnically diverse health workforce. This study explores a tertiary admission programme targeting Māori and Pacific applicants to nursing, pharmacy and health sciences (a precursor to medicine) at the University of Auckland (UoA), Aotearoa New Zealand (NZ). Application of cognitive and non-cognitive selection tools, including a Multiple Mini Interview (MMI), are examined. Indigenous Kaupapa Māori methodology guided analysis of the Māori and Pacific Admission Scheme (MAPAS) for the years 2008-2012. Multiple logistic regression models were used to identify the predicted effect of admission variables on the final MAPAS recommendation of best starting point for success in health professional study i.e. 'CertHSc' (Certificate in Health Sciences, bridging/foundation), 'Bachelor' (degree-level) or 'Not FMHS' (Faculty of Medical and Health Sciences). Regression analyses controlled for interview year, gender and ancestry. Of the 918 MAPAS interviewees: 35% (319) were Māori, 58% (530) Pacific, 7% (68) Māori/Pacific; 71% (653) school leavers; 72% (662) females. The average rank score was 167/320, 40-80 credits below guaranteed FMHS degree offers. Just under half of all interviewees were recommended 'CertHSc' 47% (428), 13% (117) 'Bachelor' and 38% (332) 'Not FMHS' as the best starting point. Strong associations were identified between Bachelor recommendation and exposure to Any 2 Sciences (OR:7.897, CI:3.855-16.175; p MAPAS mathematics test (OR:1.043, CI:1.028-1.059; p MAPAS admissions process may provide an exemplar for other tertiary institutions looking to widen participation via equity-targeted admission processes.

  17. A predicted protein, KIAA0247, is a cell cycle modulator in colorectal cancer cells under 5-FU treatment

    Directory of Open Access Journals (Sweden)

    Chen Yan-Chu

    2011-05-01

    Full Text Available Abstract Background Colorectal cancer (CRC is the predominant gastrointestinal malignancy and the leading cause of cancer death. The identification of genes related to CRC is important for the development of successful therapies and earlier diagnosis. Methods Molecular analysis of feces was evaluated as a potential method for CRC detection. Expression of a predicted protein with unknown function, KIAA0247, was found in feces evaluated using specific quantitative real-time polymerase chain reaction. Its cellular function was then analyzed using immunofluorescent staining and the changes in the cell cycle in response to 5-fluorouracil (5-FU were assessed. Results Gastrointestinal tissues and peripheral blood lymphocytes ubiquitously expressed KIAA0247. 56 CRC patients fell into two group categories according to fecal KIAA0247 mRNA expression levels. The group with higher fecal KIAA0247 (n = 22; ≥ 0.4897 had a significantly greater five-year overall survival rate than the group with lower fecal KIAA0247 (n = 30; p = 0.035, log-rank test. Fecal expression of KIAA0247 inversely related to CRC tumor size (Kendall's tau-b = -0.202; p = 0.047. Immunofluorescent staining revealed that the cytoplasm of CRC cells evenly expresses KIAA0247 without 5-FU treatment, and KIAA0247 accumulates in the nucleus after 40 μM 5-FU treatment. In HCT116 p53-/- cells, which lack p53 cell cycle control, the proportion of cells in the G2/M phase was larger (13% in KIAA0247-silent cells than in the respective shLuc control (10% and KIAA0247-overexpressing cells (7% after the addition of low dose (40 μM 5-FU. Expression of three cyclin genes (cyclin A2, cyclin B1, and cyclin B2 also downregulated in the cells overexpressing KIAA0247. Conclusions This is the first description of a linkage between KIAA0247 and CRC. The study's data demonstrate overexpression of KIAA0247 associates with 5-FU therapeutic benefits, and also identify the clinical significance of fecal KIAA0247

  18. rpL3 promotes the apoptosis of p53 mutated lung cancer cells by down-regulating CBS and NFκB upon 5-FU treatment.

    Science.gov (United States)

    Russo, Annapina; Saide, Assunta; Cagliani, Roberta; Cantile, Monica; Botti, Gerardo; Russo, Giulia

    2016-12-07

    5-FU is a chemotherapy drug commonly used for the treatment of human cancers; however drug resistance represents a major challenge for its clinical application. In the present study, we reporte that rpL3 induced by 5-FU treatment in Calu-6 cells represses CBS transcription and reduces CBS protein stability leading to a decrease of CBS protein levels. rpL3 also regulates negatively the activation of NFκB by preventing NFκB nuclear translocation through IκB-α up-regulation. Furthermore, we demonstrate that rpL3 significantly enhances the apoptosis of 5-FU treated Calu-6 cells promoting the overexpression of the pro-apoptotic proteins Bax and the inhibition of the anti-apoptotic protein Bcl-2. We finally demonstrate that rpL3 potentiates 5-FU efficacy inhibiting cell migration and invasion. Our results suggest that combination of rpL3 and 5-FU is a promising strategy for chemotherapy of lung cancers lacking functional p53 that are resistant to 5-FU.

  19. Wheat germ agglutinin-functionalised crosslinked polyelectrolyte microparticles for local colon delivery of 5-FU: in vitro efficacy and in vivo gastrointestinal distribution.

    Science.gov (United States)

    Glavas-Dodov, Marija; Steffansen, Bente; Crcarevska, Maja S; Geskovski, Nikola; Dimchevska, Simona; Kuzmanovska, Sonja; Goracinova, Katerina

    2013-01-01

    We have previously reported the development and characterisation of wheat germ agglutinin (WGA)-functionalised chitosan-Ca-alginate (CTS-Ca-ALG) microparticles (MPs) loaded with acid-resistant particles of 5-fluorouracil (5-FU). In the present work, our goal was to evaluate the potential of these carriers for efficient treatment of colon cancer by studying in vitro permeability and cell association of 5-FU and [methyl-³H]thymidine uptake in Caco-2 cells, as well as in vivo gastrointestinal distribution. The amount of 5-FU permeated through Caco-2 cells was 15.1, 7.7 and 6.5% for 5-FU solution, CTS-Ca-ALG MPs and WGA conjugates. The concentration of 5-FU associated with Caco-2 cells was significantly greater when delivered from MPs. By incorporation of 5-FU into MPs and further decoration with WGA, an increased [methyl-³H]thymidine uptake was observed few hours after continuous drug treatment followed by significantly reduced uptake after 6 h. Gastrointestinal distribution was in favour of increased localisation and concentration of the particles in colon region.

  20. Wheat germ allutinin functionalized crosslinked polyelectrolyte microparticles for local colon delivery of 5-FU: In vitro efficacy and in vivo gastrointestinal distribution

    DEFF Research Database (Denmark)

    Glavas-Dodov, Marija; Steffansen, Bente; Crcarevska, Maja

    2013-01-01

    We have previously reported the development and characterisation of wheat germ agglutinin (WGA)-functionalised chitosan-Ca-alginate (CTS-Ca-ALG) microparticles (MPs) loaded with acid-resistant particles of 5-fluorouracil (5-FU). In the present work, our goal was to evaluate the potential...... of these carriers for efficient treatment of colon cancer by studying in vitro permeability and cell association of 5-FU and [methyl-³H]thymidine uptake in Caco-2 cells, as well as in vivo gastrointestinal distribution. The amount of 5-FU permeated through Caco-2 cells was 15.1, 7.7 and 6.5% for 5-FU solution, CTS......-Ca-ALG MPs and WGA conjugates. The concentration of 5-FU associated with Caco-2 cells was significantly greater when delivered from MPs. By incorporation of 5-FU into MPs and further decoration with WGA, an increased [methyl-³H]thymidine uptake was observed few hours after continuous drug treatment followed...

  1. Spectral energy distribution analysis of class I and class II FU Orionis stars

    Energy Technology Data Exchange (ETDEWEB)

    Gramajo, Luciana V.; Gómez, Mercedes [Observatorio Astronómico, Universidad Nacional de Córdoba, Argentina, Laprida 854, 5000 Córdoba (Argentina); Rodón, Javier A., E-mail: luciana@oac.uncor.edu, E-mail: mercedes@oac.uncor.edu, E-mail: jrodon@eso.org [European Southern Observatory, Alonso de Córdova 3107, Vitacura, Casilla 19001, Santiago 19 (Chile)

    2014-06-01

    FU Orionis stars (FUors) are eruptive pre-main sequence objects thought to represent quasi-periodic or recurring stages of enhanced accretion during the low-mass star-forming process. We characterize the sample of known and candidate FUors in a homogeneous and consistent way, deriving stellar and circumstellar parameters for each object. We emphasize the analysis in those parameters that are supposed to vary during the FUor stage. We modeled the spectral energy distributions of 24 of the 26 currently known FUors, using the radiative transfer code of Whitney et al. We compare our models with those obtained by Robitaille et al. for Taurus class II and I sources in quiescence periods by calculating the cumulative distribution of the different parameters. FUors have more massive disks: we find that ∼80% of the disks in FUors are more massive than any Taurus class II and I sources in the sample. Median values for the disk mass accretion rates are ∼10{sup –7} M {sub ☉} yr{sup –1} versus ∼10{sup –5} M {sub ☉} yr{sup –1} for standard young stellar objects (YSOs) and FUors, respectively. While the distributions of envelope mass accretion rates for class I FUors and standard class I objects are similar, FUors, on average, have higher envelope mass accretion rates than standard class II and class I sources. Most FUors (∼70%) have envelope mass accretion rates above 10{sup –7} M {sub ☉} yr{sup –1}. In contrast, 60% of the classical YSO sample has an accretion rate below this value. Our results support the current scenario in which changes experimented by the circumstellar disk explain the observed properties of these stars. However, the increase in the disk mass accretion rate is smaller than theoretically predicted, although in good agreement with previous determinations.

  2. 藤黄酸合用氟尿嘧啶抗肿瘤活性的研究%Anti-tumor Activity of Gambogic Acid Combined with 5-Fu

    Institute of Scientific and Technical Information of China (English)

    骞秀芳; 郭喆; 史小四; 刘丹

    2013-01-01

    目的:探讨藤黄酸(GA)与氟尿嘧啶(5-Fu)联合应用的抗肿瘤活性.方法:MTT法观察GA合用5-Fu对刀豆蛋白A诱导的小鼠脾细胞增殖的影响;小鼠接种S180肉瘤,分为模型组、GA组(20 mg·kg-1)、5-Fu组(20 mg·kg-1)、GA合用5-Fu组(GA 20 mg · kg-1 + 5-Fu 20 mg·kg-1),每组10只,腹腔注射给药10 d后,各组称体质量,取瘤体、脾脏和胸腺称质量,计算抑瘤率、脾指数、胸腺指数.结果:GA合用5-Fu对淋巴细胞增殖表现出较强的抑制活性(P<0.01),抑制作用随药物浓度的增加而提高.GA合用5-Fu组的瘤质量与模型组、GA组、5-Fu组相比明显降低(P<0.01),抑瘤率达62.4%,明显大于单用GA或5-Fu.与5-Fu组相比,GA合用5-Fu可明显提高脾指数和胸腺指数(P<0.05).结论:GA合用5-Fu具备良好的体内外抗肿瘤活性,有协同作用.%Objective:To investigate the anti-tumor activity of gambogic acid (GA) combined with 5-fluorouracil (5-Fu).Method:The effect of GA plus 5-Fu on the mouse spleen lymphocyte proliferation in vitro was determined by an MTT assay.The mice were transplanted tumor S180,then divided into 4 groups randomly:GA group (20 mg · kg-1),5-Fu group (20 mg · kg-1),GA plus 5-Fu group (20 mg· kg-1 +20 mg · kg-1) and the model group(n =10).All mice were with intraperitoneal injection for ten days.After body-weighting,the effect of GA plus 5-Fu on tumor growth,spleen index and thymus index was determined.Result:GA plus 5-Fu significantly inhibited the proliferation of lymphocytes induced by ConA in a dose-dependent manner(P <0.01).The tumor growth in GA plus 5-Fu group was notablyinhibited compared with that in the model group (P < 0.01).The S180 inhibition rate in GA plus 5-Fu group reached 62.4%,which was higher than that in GA and 5-Fu group.In addition,GA plus 5-Fu had a protective effect on immune suppression caused by 5-Fu.Conclusion:GA plus 5-Fu can inhibit tumor growth effectively with a synergism.

  3. Théories à processus duaux et théories de l’éducation : le cas de l’enseignement de la pensée critique et de la logique

    Directory of Open Access Journals (Sweden)

    Guillaume Beaulac

    2011-05-01

    Full Text Available Plusieurs théories de l’enseignement de la logique et de la pensée critique prennent pour acquis que l’apprentissage théorique, celui des règles formelles par exemple, et son application pratique sont suffisants pour maîtriser les outils enseignés et pour prendre l’habitude de les mettre en usage. Toutefois, tout indique que cet enseignement n’est pas efficace, une conclusion supportée par plusieurs travaux en sciences cognitives. Approcher l’étude de la cognition évolutionnairement avec les théories à processus duaux permet une explication de ces insuffisances, tout en offrant des pistes pour aborder l’enseignement de la pensée critique et de la logique de manière plus efficace. Dans cet article, nous souhaitons présenter cette approche et explorer ces pistes de solution afin de faire quelques recommandations pédagogiques et mettre en place un cadre théorique. Nous présenterons un exemple d’application de ce programme de recherche avec la philosophie pour enfants.Many theories about the teaching of logic and critical thinking take for granted that theoretical learning, the learning of formal rules for example, and its practical application are sufficient to master the tools taught and to take the habit of using them. However, this way of teaching is not efficient, a conclusion supported by much work in cognitive science. Approaching cognition evolutionarily with dual-process theories allows for an explanation of these insufficiencies and offers clues on how we could teach critical thinking and logic more efficiently. In this article, we want to present this approach and explore these leads in order to make some pedagogical recommendations and lay the foundations of a framework. We will put forward an example of the application of this research program with philosophy for children

  4. Retrofitting BACs with G418 resistance, luciferase, and oriP and EBNA-1 – new vectors for in vitro and in vivo delivery

    Directory of Open Access Journals (Sweden)

    Wagner Ernst

    2003-02-01

    Full Text Available Abstract Background Bacterial artificial chromosomes (BACs have been used extensively for sequencing the human and mouse genomes and are thus readily available for most genes. The large size of BACs means that they can generally carry intact genes with all the long range controlling elements that drive full levels of tissue-specific expression. For gene expression studies and gene therapy applications it is useful to be able to retrofit the BACs with selectable genes such as G418 resistance, reporter genes such as luciferase, and oriP/EBNA-1 from Epstein Barr virus which allows long term episomal maintenance in mammalian cells. Results We describe a series of retrofitting plasmids and a protocol for in vivo loxP/Cre recombination. The vector pRetroNeo carries a G418 resistance cassette, pRetroNeoLuc carries G418 resistance and a luciferase expression cassette, pRetroNeoLucOE carries G418 resistance, luciferase and an oriP/EBNA-1 cassette and pRetroNeoOE carries G418 resistance and oriP/EBNA-1. These vectors can be efficiently retrofitted onto BACs without rearrangement of the BAC clone. The luciferase cassette is expressed efficiently from the retrofitting plasmids and from retrofitted BACs after transient transfection of B16F10 cells in tissue culture and after electroporation into muscles of BALB/c mice in vivo. We also show that a BAC carrying GFP, oriP and EBNA-1 can be transfected into B16F10 cells with Lipofectamine 2000 and can be rescued intact after 5 weeks. Conclusion The pRetro vectors allow efficient retrofitting of BACs with G418 resistance, luciferase and/or oriP/EBNA-1 using in vivo expression of Cre. The luciferase reporter gene is expressed after transient transfection of retrofitted BACs into cells in tissue culture and after electroporation into mouse muscle in vivo. OriP/EBNA-1 allows stable maintenance of a 150-kb BAC without rearrangement for at least 5 weeks.

  5. A randomized phase III multicenter trial comparing irinotecan in combination with the Nordic bolus 5-FU and folinic acid schedule or the bolus/infused de Gramont schedule (Lv5FU2) in patients with metastatic colorectal cancer

    DEFF Research Database (Denmark)

    Glimelius, B; Sørbye, H; Balteskard, L

    2008-01-01

    not differ (4% versus 6%, P = 0.3). Grade 3/4 neutropenia (11% versus 5%, P = 0.01) and grade 2 alopecia (18% versus 9%, P = 0.002) were more common in the FLIRI group. The 60-day mortality was 2.4% versus 2.1%. CONCLUSIONS: Irinotecan with the bolus Nordic schedule (FLIRI) is a convenient treatment with PFS...... and OS comparable to irinotecan with the Lv5FU2 schedule. Neutropenia and alopecia are more prevalent, but both regimens are equally well tolerated....

  6. 唐末辞赋创作的转向与赋学思想论%Fu Writing in Late Tang Dynasty:Change and Ideology

    Institute of Scientific and Technical Information of China (English)

    孙福轩

    2013-01-01

    The late Tang dynasty is an important period in the history of Fu study when changes appear in Fu writing of each type .Content of comments and reasoning was merged into Sao style Fu besides the emotions . Rhythmical prose style Fu was also added with comment and reasoning , divorcing from the beauty and paralleling style in the early Tang dynasty .Symmetrical style Fu was not the content for imperial examination and used to chant the past and express the emotions , thus creating the verse Fu .In Fu ideology , ideas of valuing feelings and empha-sizing the past appear , while schools of euphuism and satire exist together .The view to Qu Yuan , Song Yu and Yang Xiong had changed to some extent .%唐末是中国赋学发展史上的一个较为重要的历史时期,各体辞赋创作纷纷出现转向,骚体赋在言情之外,融入议论说理的成分;骈体赋脱离了唐初以来的俪美和骈对习气,亦以议论、说理入赋;律体赋脱离科举,转向咏古和对情志的抒发,文体赋开始出现。在赋学思想上,表现出辞采派和讽谏派的交互,同时也有重情和重古的观点出现,对屈原、宋玉和扬雄的看法也有不同程度的转变。

  7. MiR-122 increases sensitivity of drug-resistant BEL-7402/5-FU cells to 5-fluorouracil via down-regulation of bcl-2 family proteins.

    Science.gov (United States)

    Yin, Jie; Tang, Hui Fang; Xiang, Qiong; Yu, Jia; Yang, Xiao Yang; Hu, Nan; Lei, Xiao Yong

    2011-12-01

    To investigate the changes in drug sensitivity of miR-122 transfected BEL-7402/5-FU cells. MiR-122 and negative miRNA expression vectors were constructed and stably transfected into BEL-7402/5-FU cells. Real-time RT-PCR was used to detect the level of miR-122, Bcl-XL, Bcl-2 and P53 mRNA. Western Blotting was used to detect Bcl-2, Bcl-XL and P53 protein expression. Drug sensitivity of the cells to 5-fluorouracil (5-FU) was analyzed with MTT and flow cytometry. Compared with negative miRNA transfectants or untreated cells, mRNA and protein expression level of Bcl-2, Bcl-XL in stable miR-122 transfectants were decreased. Accordingly, P53 protein expression showed a significant up-regulation; MTT results showed that after incubation with 5-FU, miR-122 transfectants had higher cell inhibitory rates than negative miRNA or untreated cells; flow cytometry results demonstrated that apoptosis rate increased in miR-122 transfected cells, compared with negative miRNA or untreated cells. After addition of 5-FU (10 and 100 micromol/I), miR-122 transfected cells showed higher apoptosis rate than negative miRNA or untreated cells. MiR-122 can specifically down-regulate the expression of Bcl-2 and Bcl-XL, and increase P53 activity in BEL-7402/5-FU cells, which increased cells spontaneous apoptosis and sensitize cells to 5-FU. Therefore, MiR-122 can be used as a potential therapy agent against human hepatoblastoma.

  8. Resveratrol synergistically augments anti-tumor effect of 5-FU in vitro and in vivo by increasing S-phase arrest and tumor apoptosis.

    Science.gov (United States)

    Dun, Jiening; Chen, Xueyan; Gao, Haixia; Zhang, Yan; Zhang, Huajun; Zhang, Yongjian

    2015-12-01

    Many studies have shown that natural dietary agents, in combination with chemical agents, can improve the therapeutic response of cancers to chemotherapy and reduce the associated side-effects. In the present study, we investigated the therapeutic potential and mechanisms of anticancer effects for the combination of 5-fluorouracil (5-FU) and resveratrol (Res). In these studies, we employed the cancer cell lines TE-1 and A431 and an animal model of skin cancer. The presented results provide the first evidence that Res can enhance the anti-tumor potency of 5-FU by inducing S-phase arrest. The combination of Res and 5-FU demonstrates synergistic efficacy, causing tumor regression in a two-stage model of mouse skin carcinogenesis induced by DMBA and TPA. There was clear evidence of Res augmenting the growth inhibitory effect of 5-FU on the TE-1 and A431 cancer cells in vitro. In the in vivo studies, the tumor regression rate in the combination group increased significantly after four weeks of treatment (P 5-FU and Res significantly increased the percentage of apoptotic cells and the level of activated caspase-3, cleaved PARP and p53 proteins as well as increased the Bax/Bcl-2 ratio. In conclusion, the 5-FU/Res combination enabled a more effective inhibition of cell growth and the induction of apoptosis in cancer cells than 5-FU alone. The results of this study suggest that chemotherapy using natural dietary agents with chemical agents represents a superior cancer treatment option.

  9. Comparison of MACT and 5Fu+ACT-D chemotherapy regimens in the treatment of low-risk gestational trophoblastic neoplasia.

    Science.gov (United States)

    Wang, Yu; Miao, Jin-Wei; Wang, Tong; Wang, Yan; Wu, Yu-Mei; Kong, Wei-Min; Su, Li; Duan, Wei

    2016-04-01

    The study aimed to compare the efficacy of methotrexate (MTX) cervical injections + actinomycin-D (ACT-D)(MACT) and 5-fluorouracil (5-Fu) + actinomycin-D (5-Fu plus ACT-D) chemotherapy regimens for low-risk gestational trophoblastic neoplasia (LR-GTN). Clinical data from 66 LR-GTN patients, admitted to the Beijing Obstetrics and Gynecology Hospital from January 2010 to April 2012, were analysed retrospectively. In total, 32 patients were treated with a MACT therapeutic regimen and the remaining 34 with a 5Fu + ACT-D therapeutic regimen. Complete remission rates (CR), duration of treatment, hospital stay and toxicity effects were compared. There was no statistical difference in CR for the MACT (90.63%) or the 5-Fu plus ACT-D (100%) therapeutic regimens (p = 0.0676) or in the duration of treatment [MACT (3.50) or 5-Fu plus ACT-D (3.71; p = 0.2021)]. Moreover, the hospital stay in the 5-Fu plus ACT-D group (32.88 days) was significantly longer than for the MACT group (22.09 days; p < 0.001). Furthermore, the degree of myelosuppression, nausea and vomiting, diarrhoea, stomatitis and alopecia was more severe in the 5Fu + ACT-D group (p < 0.01). However, there was no statistical difference in the severity of liver function damage between the two groups. A shorter hospital stay, lower hospitalization cost and slightly more toxic effects were observed in LR-GTN patients treated with the MACT therapeutic regimen. We suggest that the MACT regimen should be used as first-line chemotherapy for LR-GTN.

  10. 浅析班固赋学观的矛盾%ANALYSIS ON THE CONTRADITIONS OF BAN GU'S VIEW ON HAN FU STUDY

    Institute of Scientific and Technical Information of China (English)

    余江; 刘雪妮

    2012-01-01

    As a literature genre of the Han Dynasty, Han Fu was born in contradictive and awkward situations. The Han Fu-writers are further plagued with contradictions and suffering. Ban Gu is one of the greatest Four Han Fu-writers in the Hart Dynasty. His view on Hart Fu study is distinctive and unique. The connotation and reasons implied in his Hart Fu verse are profound. His contradictive Confucius-poetic-based view on Han Fu, the divergence between his self-contradictive art criticism and theory and his literature production are the specific embodiment of his understanding of Fu--a special literature genre. Ban Gu's contradiction is mainly caused by the complexity of his social status identity and Scholars' special living condition and state of mind.%汉赋作为有汉一代之文学,从产生之初就伴随和背负上了重重矛盾和尴尬,赋家本身更是充满了矛盾和煎熬。斑回作为“汉赋四大家”之一.其围绕赋表现出的矛盾有其深刻的内涵和原因.他的赋学观鲜明而独特。他基于儒家诗学观的矛盾赋学观、自相矛盾的赋体艺术批评以及理论与创作的自我割裂与背叛是他对赋这种特殊文体的认识矛盾重重的具体表现。班固的矛盾主要缘于其身份的复杂性和当时士人特殊的生存状态与心态。

  11. 白花蛇舌草注射液逆转人肝癌细胞BEL-7402/5-FU 的多药耐药作用%Effect of Hedyotic diffusa injection in reversing multi-drug resistance of human hepatoma BEL-7402/5-FU cells

    Institute of Scientific and Technical Information of China (English)

    廖作庄; 韦丽美; 徐灵源; 梁钢

    2015-01-01

    Objective To study the effect and mechanism of Hedyotic diffusa injection in reversing multi-drug resistance of BEL-7402/5-FU cells.Methods The IC50 of BEL-7402/5-FU cells was examined by MTT,apoptosis was detected by flow cytometry,and the content of tyrosine kinase in total protein of tumor cells was detected by enzyme-linked immunosorbent assay (ELISA).Results The IC50 of Hedyotic diffusa injection (6 μL/mL ) combined with 5-FU (636.5 μmol/L)decreased significantly compared with that of 5-FU applied alone (1 071.6 6μmol/L). The reversal on BEL-7402/5-FU was 1.68-fold.After injection of 5-FU plus Hedyotic diffusa ,the apoptosis rate of BEL-7402/5-FU cells was increased significantly and the tyrosine kinases of BEL-7402/5-FU cells decreased significantly.Conclusion Hedyotic diffusa injection plays a certain role in reversing multi-drug resistance of BEL-7402/5-FU cells,which may be related to decreasing their tyrosine kinases.%目的:研究白花蛇舌草注射液对 BEL-7402/5-FU 细胞多药耐药的逆转作用,并探讨其作用机制。方法四甲基偶氮唑蓝(MTT)法检测药物对 BEL7402/5-FU 细胞的半数抑制浓度(IC50);流式细胞仪检测细胞凋亡;ELISA 双抗体一步夹心法测定酪氨酸激酶含量。结果无毒剂量的白花蛇舌草注射液(6μL/mL)联合5-FU 对 BEL-7402/5-FU细胞的 IC50为636.5μmol/L,比单独应用5-FU 的 IC50(1071.6μmol/L)明显下降,逆转倍数为1.68;加白花蛇舌草注射液后,5-FU 对 BEL-7402/5-FU 细胞的凋亡比例明显增加,且显著下调 BEL-7402/5-FU 细胞的酪氨酸激酶含量。结论白花蛇舌草注射液对 BEL-7402/5-FU 细胞的多药耐药性具有一定的逆转作用,其机制可能与下调酪氨酸激酶有关。

  12. The coronary dilation effect of shen fu injection was mediated through NO.

    Directory of Open Access Journals (Sweden)

    Yu Hong Li

    Full Text Available OBJECTIVES: Shen Fu Injection (SF, which consisted of Red ginseng extraction injection (RG and prepared aconite extraction injection (RA, is a traditional Chinese medicine mainly used for various cardiac diseases. This study is to analyse SF's effects on cardiac performance and coronary circulation. And the coronary dilating effect and mechanism of the above three injections were also explored. METHODS: Mature male guinea pigs were used as our animal model. We employed two types of perfusion methods (constant pressure and constant flow in vitro, using Langendorff heart preparations to observe the cardiac function and coronary response to SF (1/200. The coronary dilation effects of the above three injections (1/800, 1/400 and 1/200 were recorded at basal coronary resting tone and when coronary vessels were pre-contracted with a thromboxane A2 analogue (U46619, in the presence or the absence of the inhibitor of nitric oxide synthesis (L-NAME, 10-4 M, the blocker of Ca2+-activated potassium channel(TEA, 10-3 M, or the blocker of adenosine triphosphate (ATP-sensitive potassium channel (glybenclamide (10-5 M. RESULTS: When perfused with constant pressure, SF significantly increased coronary flow, left ventricular developed pressure (LVDP and the rate-pressure product (RPP. When perfused with constant flow, SF produced a significant reduction in the coronary perfusion pressure (CPP, LVDP and RPP. The coronary vasodilatation response of the above three injections can be reduced by L-NAME but was unaffected by TEA or glybenclamide when coronary vessels were pre-contracted with U46619 but not at resting tone. SF, RG and RA can all up-regulate eNOS expression in the human umbilical vein cells (EA.hy926. CONCLUSION: We demonstrated that SF does not contribute to the inotropic change of myocardium whose improvement is due to alternation of coronary flow. The coronary dilation effect of SF was mediated through RG and RA, via promoting NO release.

  13. Maps of Relocation and Poems of Tang Dynasty Poets: Li Bai, Du Fu, and Han Yu

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    羅鳳珠、白璧玲、廖泫銘、范毅軍 、鄭錦全 Feng-Ju Lo,Pi-Ling Pai,Hsiung-Ming Liao,I-Chun Fan,Chin-Chuan Cheng

    2014-04-01

    Full Text Available Geographic environments affect literary contents and genre and thus, since ancient times, geographical area has been used to classify Chinese literature. In 1936 Liang Qichao was keenly aware of the relationship between literature and geography and brought up the idea of “literarygeography”. In 1979 Professor Chen Zhengxiang produced maps of birthplaces of Tang and Song poets to show the shift of Chinese cultural center from north to south. Furthermore, in the pastdecade, the attention to research in literary geography and geographical distribution of writersgradually increased. However, most studies focused on geographical distribution of birthplaces of writers and very few focused on the relationship between poets’ journey and the contents of their writings and their geographic environment. Meanwhile, geographic information system and aerialphotography have developed quickly and have become useful tools for the study of literary geography.Since then, the academic circles in Taiwan have built a solid foundation in this area. While Li Baiand Du Fu were called poetic immortal and poetic sage of the middle and end periods of the heydayof Tang Dynasty, respectively, Han Yu advocated the classical Chinese movement and becameone of the eight great authors of Tang and Song dynasties. Han Yu was also the best representative of Middle Tang poets. While the styles of these three poets differed from each other, they held key positions in the development and evolution of Tang poetry. Their footprints spread all over the countryand greatly affected later developments and contemporary of poetry. This project makes use of the digital Tang Dynasty maps by Tan Qixiang, Tang Dynasty transportation route maps by Yan Gengwang,aerial maps, the All Tang Poems, and chronicles of the poets to build the three poets’ relocation maps and study their poetic literature, language, geography, and interactions with others, in hopesof opening a new research direction

  14. Electromyographic Study of a Sequence of Yau-Man Kung Fu Palm Strikes with and without Impact.

    Science.gov (United States)

    Neto, Osmar Pinto; Magini, Marcio; Pacheco, Marcos T T

    2007-01-01

    IN MARTIAL ARTS AND CONTACT SPORTS, STRIKES ARE OFTEN TRAINED IN TWO DIFFERENT WAYS: with and without impacts. This study aims to compare the electromyographical activity (EMG) of the triceps brachii (TB), biceps brachii (BB) and brachioradialis (BR) muscles during strikes with and without impacts. Eight Yau-Man Kung Fu practitioners participated in the experiment. Each participant performed 5 sequences of 5 consecutive KF Yau-Man palm strikes with no impact intercalated with 5 sequences of 5 repetitions targeting a KF training shield. Surface EMG signals were obtained from the TB, BB, and RB for 3.0 seconds using an eight-channel module with a total amplifier gain of 2000 and sampled at 3500 Hz. The EMG analyses were done in the time (rms) and frequency (wavelet) domains. For the frequency domain, Morlet wavelet power spectra were obtained and an original method was used to quantify statistically significant regions on the power spectra. The results both in the time and frequency domains indicate a higher TB and BR muscle activity for the strikes with impacts. No significant difference was found for the BB in the two different scenarios. In addition, the results show that the wavelet power spectra pattern for the three analysed muscles obtained from the strikes with and without impacts were similar. Key pointsEMG analysis of a sequence of Kung Fu strikes demonstrates higher Triceps Brachii and Brachioradialis muscle activity for strikes with impact than strikes without impact.An original reliable method for quantifying EMG wavelet transform results is presented.EMG wavelet power spectra describe muscle roles during a Kung Fu sequence of strikes.

  15. On the Origination about the Theme of Wild Goose Fu%论雁赋主题渊源

    Institute of Scientific and Technical Information of China (English)

    赵金平

    2016-01-01

    雁在上古典籍中就被赋予丰富的文化意蕴,人们将雁的特征与习性和世俗的事物联系起来,或寓意祥瑞与纯贞,或象征礼仪与秩序,或譬喻懿德与壮志,或寄寓感慨,抒发生命体悟,雁赋主题渊源于此,后世传承上古典籍中的雁文化,既有因循又有变革。在分析雁赋文本的基础上,对雁赋主题进行类分,进而对其主题渊源进行分析。雁赋传承并丰富了民族文化,是中华民族智慧和情感的体现。%Wild geese were endowed with abundant cultural connotations in ancient texts.People related characteristics and habits of wild geese to world things,presenting auspicious sign and pure state,or symboli-zing etiquette and order,or analogizing with virtue and ambition,or reflecting their feelings and expressing the awareness of life,and so on.The theme of the wild goose originated from these good things,not only inherited the culture of wild goose in ancient classics,but also changed and reformed.Based on the analysis of wild goose culture,the paper classifies the themes of wild goose Fu and then discusses the origination about themes of wild goose Fu.Wild goose Fu inherited and enriched our ethnic culture,and presented the wisdoms and feelings of Chinese nationality.

  16. Quantitative analysis of a Māori and Pacific admission process on first-year health study.

    Science.gov (United States)

    Curtis, Elana; Wikaire, Erena; Jiang, Yannan; McMillan, Louise; Loto, Robert; Airini; Reid, Papaarangi

    2015-11-03

    Universities should provide flexible and inclusive selection and admission policies to increase equity in access and outcomes for indigenous and ethnic minority students. This study investigates an equity-targeted admissions process, involving a Multiple Mini Interview and objective testing, advising Māori and Pacific students on their best starting point for academic success towards a career in medicine, nursing, health sciences and pharmacy. All Māori and Pacific Admission Scheme (MAPAS) interviewees enrolled in bridging/foundation or degree-level programmes at the University of Auckland were identified (2009 to 2012). Generalised linear regression models estimated the predicted effects of admission variables (e.g. MAPAS Maths Test; National Certificate in Educational Achievement (NCEA) Rank Score; Any 2 Sciences; Followed MAPAS Advice) on first year academic outcomes (i.e. Grade Point Average (GPA) and Passes All Courses) adjusting for MAPAS interview year, gender, ancestry and school decile. 368 First Year Tertiary (bridging/foundation or degree-level) and 242 First Year Bachelor (degree-level only) students were investigated. NCEA Rank Score (estimate 0.26, CI: 0.18-0.34, pMAPAS Advice Followed (1.26, CI: 0.18-1.34, p = 0.0002); Exposure to Any 2 Sciences (0.651, CI: 0.15-1.15, p = 0.012); and MAPAS Mathematics Test (0.14, CI: 0.02-0.26, p = 0.0186) variables were strongly associated with an increase in First Year Tertiary GPA. The odds of passing all courses in First Year Tertiary study was 5.4 times higher for students who Followed MAPAS Advice (CI: 2.35-12.39; pMAPAS Advice had an average GPA that was 1.1 points higher for all eight (CI: 0.45-1.73; p = 0.0009) and Core 4 courses (CI: 0.60-2.04; p = 0.0004). The MAPAS admissions process was strongly associated with positive academic outcomes in the first year of tertiary study. Universities should invest in a comprehensive admissions process that includes alternative entry pathways for

  17. La théorie sémiotique littéraire de Michael Riffaterre : matrice, intertexte et interprétant

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    John Hopkins

    2005-04-01

    Full Text Available Cette communication présentée lors d’un séminaire du CNA, présente une vision de la théorie littéraire de Michael Riffaterre et propose d’en compléter la portée par un apport théorique nouveau. La dernière partie examine les rapports de la théorie riffaterrienne avec le roman. Sémiotique, poésie, matrice, structure bimatricielle, Riffaterre, Baudelaire. Puisque je parle aux confins du Centre de Narratologie Appliquée, où l’on s’intéresse principalement aux questions de la structure et de...

  18. A novel comprehensive set of fungal Real time PCR assays (fuPCR) for the detection of fungi in immunocompromised haematological patients-A pilot study.

    Science.gov (United States)

    Rahn, Sebastian; Schuck, Anna; Kondakci, Mustafa; Haas, Rainer; Neuhausen, Nicole; Pfeffer, Klaus; Henrich, Birgit

    2016-12-01

    Fungal infections are recognized in an increasing number of patients with immunological deficits and are associated with high rates of mortality (Brown et al., 2012a). In this pilot-study, a rapid Real time PCR (fuPCR) was designed for the detection and differentiation of fungal pathogens in clinical specimens of haematological patients. The fuPCR, targeting the internal transcribed spacer region 2 (ITS2) of rDNA region, is comprised of seven multiplex reactions, which were shown to be specific and sensitive for a comprehensive spectrum of clinically relevant fungal species. This was validated by testing respective fungal DNAs in each fuPCR reaction and 28 respiratory samples of fungal pneumonia-proven patients. Clinical sample sets of throat swab, EDTA-blood and blood sera from 50 patients with severe haematological malignancies, including haematopoietic stem cell transfer (HSCT), and samples from 30 healthy individuals were then analysed. In a first step, 198 samples of immunosuppressed patients were solely examined by fuPCR; and 50.8% (33/65) respiratory swabs, 4.8% (3/63) EDTA blood samples and 1.4% (1/70) blood serum samples were tested positive. In a second step, 56 respiratory samples of immunosuppressed patients and 30 of healthy individuals were simultaneously analysed by fuPCR and standard cultivation techniques. By both methods 30.4% (17/56) swabs of the immunocompromised patients were tested positive, 37.5% (21/56) were tested negative and 32.1% (18/56) were tested fuPCR positive and culture negative. In analysing the blood samples of the immunocompromised patients 5.4% (3/56) EDTA blood samples and 16.1% (9/56) sera samples were tested fuPCR-positive, whereas all samples of 30 healthy individuals with no signs of immunological deficits were tested negative by fuPCR. 38.9% (14/36) of the fungi detected in respiratory samples of the immunosuppressed patients, belonged to Candida spp., 47.2% (17/36) to Saccharomyces spp., 5.6% (2/36) to Cladosporium spp

  19. HSP27在调控人胃癌细胞系5-FU 耐药中的作用机制%The Mechanism of HSP27 Regulation of 5-FU Resistant in Human Gastric Cancer Cell Lines

    Institute of Scientific and Technical Information of China (English)

    宋荣峰; 张慧卿; 熊彦; 王艳华; 万以叶

    2015-01-01

    目的:探讨热休克蛋白27(HSP27)在调控人胃癌细胞系5-FU耐药中的作用机制。方法培养人胃癌细胞株HGC27、BGC823、SGC7901、MKN28,采用CCK法筛选5-FU敏感株和耐药株,采用流式细胞仪和western blot 检测4株胃癌细胞株中HSP27表达水平,转染HSP27-siRNA,观察siRNA干扰后5-FU敏感株和耐药株中HSP27蛋白表达,并将两细胞株分别与不同浓度5-Fu共培养,采用CCK法检测细胞的半数抑制浓度( IC50)。结果 CCK法显示SGC7901细胞系是4株胃癌细胞中5-Fu相对耐药株,而HCG27是5-Fu相对敏感株。流式细胞仪显示SGC7901细胞株中HSP27表达水平最高为(72.10±1.89)%,而在HGC27细胞株中的表达水平最低为(22.12±1.33)%,各株表达水平比较差异有统计学意义( P<0.05)。转染HSP27-siRNA 后,各两株细胞HSP27蛋白表达水平均下降明显。与5-Fu共培养后, SGC7901细胞株转染组细胞半数抑制浓度降低,药物敏感性增强,与未转染组比较差异有统计学意义( P<0.05)。结论HSP27参与了SGC79015-FU耐药株中的细胞耐药,是诱导细胞多药耐药的重要分子机制,可以作为临床治疗靶点来提高胃癌患者对化疗的敏感性。%Objective To investigate the mechanism of HSP 27 of 5-FU resistant in human gastric cancer cell lines . Methods Human gastric cancer cell lines(HGC27,BGC823,SGC7901,MKN28)were cultured,and the cells which were resist-ant to 5-FU were selected by CCK assay and flow cytometry .The expression of HSP27 in these cells were detected by Western Blotting.And 2 cell lines were co-cultured with different concentration of 5-Fu,then the half inhibition concentration was detected by CCK assay.Results CCK assay showed that SGC7901 cell line was relatively resistant to 5-Fu,and the HCG27 cell line was relatively sensitive to 5-Fu.The flow cytometry results suggested that the expression of HSP 27 in the SGC7901 cells was

  20. [Preliminary clinical evaluation of low-dose cisplatin and continuous infusion of 5-FU (LFP) chemotherapy after weekly high-dose 5-FU therapy for the treatment of liver metastases from colorectal cancer].

    Science.gov (United States)

    Itoh, Satoshi; Morita, Sojiro; Ohnishi, Takenao; Tsuji, Akihito; Takamatsu, Masahiro; Horimi, Tadashi

    2002-07-01

    In this study, we evaluate the efficacy of low-dose cisplatin and continuous 5-FU infusion systemic chemotherapy (LFP therapy) for the treatment of unresectable and recurrent liver metastases from colorectal cancer after weekly high-dose 5-FU therapy via the hepatic artery (WHF therapy). At the start of chemotherapy, 12 patients with multiple extrahepatic lesions were treated with the LFP therapy (LFP group), and 18 patients with none or a few extrahepatic lesions were treated with the WHF therapy followed by the LFP therapy (LFP after WHF group). In the LFP group, the response rate was 50.0% (PR 6) and the one-year survival rate was 50.0%. On the contrary, in the LFP after WHF group, the response rate was 38.9% (CR 1, PR 6) and the one-year survival rate after LFP started was 46.0%. We conclude that the LFP therapy may be effective for the treatment of liver metastases from colorectal cancer even after the WHF therapy.

  1. Cyto-Fluid Dynamic Theory of Atomization Processes Une théorie cyto-fluide des processus d'atomisation

    Directory of Open Access Journals (Sweden)

    Naitoh K.

    2006-12-01

    Full Text Available A universal theory of spray atomization processes is proposed. Based on the proposed theory, previously reported empirical models and analogy models such as the TAB model and the OPT (oval-parabola trajectory model can be derived along with their arbitrary constants. Moreover, this theory provides a detailed formulation for breakup phenomena after two droplets collide. Finally, it is shown on the basis of this theory that the atomization processes of fuel coming from ancient living systems are similar to cell proliferation mathematically. The integrated research including liquid atomizations and actual biological cell divisions will bring us ways out of impasses for each field, since the target of both research fields is faster breakup of hydrocarbon droplets. Cet article propose une théorie générale de l'atomisation des sprays. À partir de cette théorie, des modèles déjà décrits, empiriques ou basés sur des analogies peuvent être obtenus et leurs constantes arbitraires déterminées. De plus, cette théorie fournit une formulation détaillée du phénomène de rupture succédant à des collisions de gouttes. Enfin, il est montré sur la base de cette théorie que le phénomène d'atomisation du carburant est équivalent mathématiquement à une prolifération cellulaire. La recherche intégrée dans les domaines de l'atomisation des liquides et la division cellulaire nous apportera des solutions aux impasses de chacun de ces deux domaines, puisque le but commun de ces deux champs de recherche est une atornisation plus rapide de gouttes d'hydrocarbure.

  2. Oriënterende meting van ammoniakemissie Holcim Sleufvloer type B = Explorative ammonia emission measurements on the Holcim grooved floor type B

    OpenAIRE

    Dooren, van, H.J.C.; Blanken, K.; Gunnink, H.; Huis in 'T Veld, J.W.H.

    2010-01-01

    Dit rapport beschrijft de flux kamer metingen die uitgevoerd zijn aan de Holcim Sleufvloer Type B vergeleken met de sleufvloer type A en een standaard betonnen roostervloer als referentie. De ammoniakemissie bedroeg 39% van de emissie die op de roostervloer gemeten is. Het betreft hier oriënterende metingen die gevalideerd moeten worden door metingen op grotere schaal (hele stal).This report describes open flux chamber measurements on the Holcim grooved floor type B for dairy cattle compared ...

  3. Comptabilité, Finance et Politique De la pratique à la théorie : l'art de la conceptualisation

    OpenAIRE

    Alain Burlaud

    2014-01-01

    L'ouvrage traite de la comptabilité financière dans ses dimensions politiques et sociales. Il est organisé en six grandes parties : - la théorie comptable - la normalisation comptable - l'utilisation de l'information comptable - la profession comptable - la comptabilité et les systèmes d'information - la pédagogie de la comptabilité et de la gestion

  4. 论南宋诗人使用杜诗典故的特点%Characteristics of Poets" Using Allusions from Du Fu's Poems In Southern Song Dynasty

    Institute of Scientific and Technical Information of China (English)

    左汉林

    2012-01-01

    Under the background of modeling and learning from Du Fu in the Song Dynasty, poets like to cite allusions from Du Fu's poems in the South Song Dynasty. Poets in the early Southern Song Period widely use Du's allusions and Lu You is the poet who cites allusions most from Du's poems in the two Song Dynasties. Poets in the late Southern Song Period cite fewer allusions from Du Fu's poems. Poets" using allusions from Du Fu's poems reflect the atmosphere of modeling and learning from Du Fu in the poetic world of Song Dynasties.%在宋代崇杜、学杜的背景下,南宋诗人作诗喜用杜诗典故。南宋前期诗人普遍使用杜诗典故较多,陆游是两宋使用杜诗典故最多的诗人。南宋末年诗人使用杜诗典故较少。南宋对杜诗典故的使用,反映出宋代诗坛的崇杜、学杜风气。

  5. HSP90 inhibition downregulates thymidylate synthase and sensitizes colorectal cancer cell lines to the effect of 5FU-based chemotherapy.

    Science.gov (United States)

    Nagaraju, Ganji Purnachandra; Alese, Olatunji B; Landry, Jerome; Diaz, Roberto; El-Rayes, Bassel F

    2014-10-30

    Cell cycle progression and DNA synthesis are essential steps in cancer cell growth. Thymidylate synthase (TS) is a therapeutic target for 5FU. We tested the hypothesis that HSP90 transcriptional and functional inhibition can inhibit cell cycle progression, downregulate TS levels and sensitize colorectal cancer (CRC) cell lines to the effects of 5FU. Treatment with ganetespib (50 nM) for 24 hours inhibited cyclin D1 and pRb at the transcriptional and translational levels and induced p21, leading to G0/G1 cell cycle arrest in both CRC cell lines (HCT-116 and HT-29). This was associated with downregulation of E2F1 and its target gene TS. In addition, ganetespib inhibited PI3K/Akt and ERK signalling pathways. Similar effects were observed with HSP90 knockdown in both cell lines. Ganetespib sensitized CRC cell lines to the effects of oxaliplatin and 5FU. Similar effects were also observed in tumors from animals treated with ganetespib, oxaliplatin and 5FU. In this study, we present in vitro and animal data supporting that the targeting of HSP90 decreases CRC cell survival and proliferation. Ganetespib sensitizes CRC cell lines to the effects of 5FU-based chemotherapy. Combining HSP90 inhibitors with chemotherapy is a rational approach for future drug development in CRC.

  6. Effects of traditional Chinese medicine Fu Zheng decoction on the immunological function and clinical prognosis of the elderly patients with pneumonia.

    Science.gov (United States)

    Li, Hongqiang; Xu, Shumin; Cheng, Tingting; Tang, Lunxian; Bai, Jianwen; Lin, Minjia

    2015-01-01

    Pneumonia is one of the most serious infectious diseases for elderly people who have impaired organ functions and are more susceptible to infection. Elderly patients having pneumonia often need long-term hospitalization, leading to declined quality of life, and increase of financial burden to the society and their family. Therefore, studies on novel therapeutic strategies and the clinical prognosis of the pneumonia patients are imperative. In the present study, we found that the Chinese herbal medicine Fu Zheng decoction had great immunomodulatory effects during the recovery period of elderly pneumonia patients. Patients treated with combined treatment of Fu Zheng decoction and antibiotic had a faster decline of temperature and a more significant decrease of C reactive protein and inflammatory factors level, and it is easier for them to cough off phlegm, compared with the antibiotic only treatment. Furthermore, the inflammation absorption and the reduction of NK-cell proportion as well as the inflammatory factors were more remarkable in the patients taken Fu Zheng decoction. Especially, the Fu Zheng decoction treatment could decrease the duration of antibiotic treatment, which may help reduce the side effects of antibiotics. Our study also found that MyD88 might play a role in the immunomodulatory effect of Fu Zheng decoction. Our study provides novel insight for the further development of intravenous injection of Chinese materia medica preparation on the regulation of immune function.

  7. Whakawhiti Kōrero, a Method for the Development of a Cultural Assessment Tool, Te Waka Kuaka, in Māori Traumatic Brain Injury

    Directory of Open Access Journals (Sweden)

    Hinemoa Elder

    2015-01-01

    Full Text Available The importance of tools for the measurement of outcomes and needs in traumatic brain injury is well recognised. The development of tools for these injuries in indigenous communities has been limited despite the well-documented disparity of brain injury. The wairua theory of traumatic brain injury (TBI in Māori proposes that a culturally defined injury occurs in tandem with the physical injury. A cultural response is therefore indicated. This research investigates a Māori method used in the development of cultural needs assessment tool designed to further examine needs associated with the culturally determined injury and in preparation for formal validation. Whakawhiti kōrero is a method used to develop better statements in the development of the assessment tool. Four wānanga (traditional fora were held including one with whānau (extended family with experience of traumatic brain injury. The approach was well received. A final version, Te Waka Kuaka, is now ready for validation. Whakawhiti kōrero is an indigenous method used in the development of cultural needs assessment tool in Māori traumatic brain injury. This method is likely to have wider applicability, such as Mental Health and Addictions Services, to ensure robust process of outcome measure and needs assessment development.

  8. XMM-Newton observation of the long-period polar V1309 Ori: The case for pure blobby accretion

    CERN Document Server

    Schwarz, R; Beuermann, K; Burwitz, V

    2005-01-01

    Using XMM-Newton we have obtained the first X-ray observation covering a complete orbit of the longest period polar, V1309 Ori. The X-ray light curve is dominated by a short, bright phase interval with EPIC pn count rates reaching up to 15 cts/sec per 30 sec resolution bin. The bright phase emission is well described by a single blackbody component with kT_bb = (45 +- 3) eV. The absence of a bremsstrahlung component at photon energies above 1 keV yields a flux ratio F_bb/F_br > 6700. This represents the most extreme case of a soft X-ray excess yet observed in an AM Herculis star. The bright, soft X-ray emission is subdivided into a series of individual flare events supporting the hypothesis that the soft X-ray excess in V1309 is caused by accretion of dense blobs. In addition to the bright phase emission, a faint, hard X-ray component is visible throughout the binary orbit with an almost constant count rate of 0.01 cts/sec. Spectral modelling indicates that this emission originates from a complex multi-temper...

  9. A contracting circumbinary molecular ring with an inner cavity of about 140 AU around Ori 139-409

    CERN Document Server

    Zapata, Luis A; Ho, Paul

    2009-01-01

    Sensitive and subarcsecond resolution ($\\sim$ 0.7\\arcsec) CH$_3$OH(7$_{-2,6}$ $\\to$ 6$_{-2,5}$) line and 890 $\\mu$m continuum observations made with the Submillimeter Array (SMA) towards the hot molecular circumbinary ring associated with the young multiple star Ori 139-409 are presented. The CH$_3$OH(7$_{-2,6}$ - 6$_{-2,5}$) emission from the ring is well resolved at this angular resolution revealing an inner cavity with a size of about 140 AU. A LTE model of a Keplerian disk with an inner cavity of the same size confirms the presence of this cavity. Additionally, this model suggests that the circumbinary ring is contracting with a velocity of V$_{inf}$ $\\sim$ 1.5 km s$^{-1}$ toward the binary central compact circumstellar disks reported at a wavelength of 7 mm. {\\bf The inner central cavity seems to be formed by the tidal effects of the young stars in the middle of the ring.} The ring appears to be not a stationary object. Furthermore, the infall velocity we determine is about a factor of 3 slower than the ...

  10. Exploring occupation roles of hospice family caregivers from Māori, Chinese and Tongan ethnic backgrounds living in New Zealand.

    Science.gov (United States)

    Angelo, Jennifer; Wilson, Linda

    2014-06-01

    A major challenge to occupational therapists working in palliative care is determining the best ways to help family caregivers who are caring for family members. The purpose of this study was to explore palliative caregiver occupations among Māori, Chinese and Tongan ethnicities. Six informants participated, one woman and one man from each ethnic group. In each of their homes, informants were asked to discuss what it was like caring for their dying family member. The occupational themes resulting from these interviews were food preparation, spirituality and family gathering. Therapists need to be aware of the differences in how people care for family members within their ethnicity. Implications are that occupational therapists can help families identify activities important to them within the main occupational themes: different types of foods and their preparations, various ways to express spirituality and how families gather together members of their extended family. Further, clinicians need to take on the role of a "not-knowing" but curious health-care provider in order to meet the needs of caregivers. The limitation was the small number of participants who all lived in one geographic area. Future studies should include a wider group of ethnicities.

  11. Relational Resilience in Māori, Pacific, and European Sole Parent Families: From Theory and Research to Social Policy.

    Science.gov (United States)

    Waldegrave, Charles; King, Peter; Maniapoto, Maria; Tamasese, Taimalieutu Kiwi; Parsons, Tafaoimalo Loudeen; Sullivan, Ginny

    2016-12-01

    This study reports findings and policy recommendations from a research project that applied a relational resilience framework to a study of 60 sole parent families in New Zealand, with approximately equal numbers of Māori, Pacific, and European (White) participants. The sole parent families involved were already known to be resilient and the study focused on identifying the relationships and strategies underlying the achievement and maintenance of their resilience. The study was carried out to provide an evidence base for the development and implementation of policies and interventions to both support sole parent families who have achieved resilience and assist those who struggle to do so. The three populations shared many similarities in their pathways to becoming sole parents and the challenges they faced as sole parents. The coping strategies underlying their demonstrated resilience were also broadly similar, but the ways in which they were carried out did vary in a manner that particularly reflected cultural practices in terms of their reliance upon extended family-based support or support from outside the family. The commonalities support the appropriateness of the common conceptual framework used, whereas the differences underline the importance of developing nuanced policy responses that take into account cultural differences between the various populations to which policy initiatives are directed. © 2016 Family Process Institute.

  12. The Chandra Delta Ori Large Project: Occultation Measurements of the Shocked Gas tn the Nearest Eclipsing O-Star Binary

    Science.gov (United States)

    Corcoran, Michael F.; Nichols, Joy; Naze, Yael; Rauw, Gregor; Pollock, Andrew; Moffat, Anthony; Richardson, Noel; Evans, Nancy; Hamaguchi, Kenji; Oskinova, Lida; Hamann, W. -R.; Gull, Ted; Ignace, Rico; Hole, Tabetha; Iping, Rosina; Walborn, Nolan; Hoffman, Jennifer; Lomax, Jamie; Waldron, Wayne; Owocki, Stan; Maiz-Apellaniz, Jesus; Leutenegger, Maurice; Hole, Tabetha; Gayley, Ken; Russell, Chris

    2013-01-01

    Delta Ori is the nearest massive, single-lined eclipsing binary (O9.5 II + B0.5III). As such it serves as a fundamental calibrator of the mass-radius-luminosity relation in the upper HR diagram. It is also the only eclipsing O-type binary system which is bright enough to be observable with the CHANDRA gratings in a reasonable exposure. Studies of resolved X-ray line complexes provide tracers of wind mass loss rate and clumpiness; occultation by the X-ray dark companion of the line emitting region can provide direct spatial information on the location of the X-ray emitting gas produced by shocks embedded in the wind of the primary star. We obtained phase-resolved spectra with Chandra in order to determine the level of phase-dependent vs. secular variability in the shocked wind. Along with the Chandra observations we obtained simultaneous photometry from space with the Canadian MOST satellite to help understand the relation between X-ray and photospheric variability.

  13. Noma (cancrum oris): a report of a case in a young AIDS patient with a review of the pathogenesis.

    Science.gov (United States)

    Masipa, J N; Baloyi, A M; Khammissa, R A G; Altini, M; Lemmer, J; Feller, L

    2013-06-01

    Noma (cancrum oris) is a mutilating necrotising disease of the orofacial tissues. It affects predominantly debilitated malnourished children, in whom the necrotic process may cause severe damage to mid-facial structures. Its aetiopathogenesis is uncertain, but its course is fulminating, and without timely intervention the disease may be fatal. Antibiotic treatment during any stage of necrotising stomatitis and of its sequel noma can stop progression of the disease; therefore detection and treatment of early intraoral necrotising lesions whether necrotising gingivitis, necrotising periodontitis or necrotising stomatitis are critical in preventing noma. We present an extreme case of noma in a malnourished HIV-seropositive child. There was an acute necrotic process affecting both the maxilla and the mandible with denudation of bone, spontaneous exfoliation of teeth, necrotising fasciitis and myonecrosis which destroyed the lips and cheeks and extended to the infra-orbital margins. There was severe disfigurement and severe impairment of function. Noma is primarily an anaerobic bacterial infection with secondary ischaemia leading to osteonecrosis and mid-facial destruction.

  14. Sartre et sa théorie des émotions : une confrontation avec Erving Goffman

    Directory of Open Access Journals (Sweden)

    Claude Javeau

    2010-06-01

    Full Text Available L’auteur confronte les positions de Jean-Paul Sartre et Erving Goffman. Dans son ouvrage de 1938, Esquisse d’une théorie des émotions, Jean-Paul Sartre propose une approche phénoménologique prenant doublement ses distances avec la psychanalyse et le béhaviourisme, posant l’émotion comme dégradation spontanée et vécue de la conscience en face du monde, le corps n’étant étrangement dans ce contexte rien d’autre que la croyance vécue de la conscience. L’auteur compare cette position avec la définition goffmanienne de la « situation sociale », qui identifie l’émotion comme une perturbation dans l’ordre normal du déroulement des interactions circonscrites dans la situation. L’interactionnisme symbolique est confronté à l’existentialisme sartrien et à sa position d’une structure magique sous-jacente du monde, en faisant de l’une le miroir de l’autre. Bien que s’inscrivant tous deux dans le courant phénoménologique, Jean-Paul Sartre et Erving Goffman sont ici saisis dans leur stratégie d’évitement des théories psychologiques. En conclusion est posée la question du statut heuristique à conférer au concept de « magique » invoqué par Jean-Paul Sartre.Sartre and his theory of emotions: a confrontation with GoffmanThe author confronts the positions of Jean-Paul Sartre and Erving Goffman. In his Esquisse d’une théorie des émotions (1938, Jean-Paul Sartre proposes a phenomenological approach. Taking his distances both with psychoanalysis and behaviourism, he places emotion as a spontaneous and experienced degradation of the conscience confronted with the world; the body thus becoming strangely nothing other than the experienced belief of consciousness. The author compares this position with Goffman’s definition of the “social situation”. Here, emotion is identified as a disturbance intervening in the normal order of the sequence of events delimited by the situation. Symbolic

  15. 杜诗数词的多重意义%Multiple meanings of the numerals in DU Fu's poems

    Institute of Scientific and Technical Information of China (English)

    魏耕原

    2015-01-01

    There are multiple meanings in the numerals of DU Fu's poems:firstly, the total number of poem groups shows the universality and particularity of number;secondly , special attention was paid to the digital reign title which is full of his poems;thirdly , he used lots of numerals in his poetry to record An-Shi Rebellion and the truth of history afterwards .These figures are full of feelings and desires as well as the aspirations for the future .The reality and the poetization of these figures constitute the special landscape of Du Fu's poems and reflect his broad and deep style .%杜诗里的数词具有多重意义:组诗的篇数呈现了数字的广泛性与特殊性;对表示数字式的年号特别重视,大量出现在诗中;他的诗史用了大量的数字,记录了安史之乱及其以后历史的真实。这些数字充满了感情与愿望,也充满了对未来的渴望;这些数字的真实与诗化,构成了杜诗一道又一道特殊的景观,也体现杜诗广博深沉的风格。

  16. TJ-41 Induces Apoptosis and Potentiates the Apoptotic Effects of 5-FU in Breast Cancer Cell Lines

    Directory of Open Access Journals (Sweden)

    Suresh Volate

    2009-01-01

    Full Text Available Recent studies suggest that TJ-41, a herbal drug, possesses chemotherapeutic effects. Accordingly, this study was undertaken to investigate the anticarcinogenic effects of TJ-41 on human breast cancer cells lines. TJ-41 inhibited the proliferation of human breast cancer cell lines dose dependently. Flow cytometric analysis showed that this decrease in DNA synthesis is to be associated with induction of apoptosis. In both cell lines, apoptosis was abolished by caspase-9 inhibitor Z-LEHD-fmk but was weakly inhibited by caspase-8 inhibitor Z-IETD-fmk, indicating that caspase-9 activation was involved in TJ-41 induced apoptosis. Additionally, TJ-41 stimulated phosphorylation of c-Jun NH2-terminal kinase (JNK and pretreatment of breast cancer cells with JNK inhibitor SP600125 completely abolished TJ-41 induced apoptosis. Our data also demonstrate that combined treatment of TJ-41 and 5-FU significantly potentiates the apoptotic effects of 5-FU in both breast cancer cell lines. Taken together, these data suggest that TJ-41 might provide a novel chemotherapeutic treatment for breast cancer.

  17. AT101 exerts a synergetic efficacy in gastric cancer patients with 5-FU based treatment through promoting apoptosis and autophagy.

    Science.gov (United States)

    Wei, Xi; Duan, Wei; Li, Ying; Zhang, Sheng; Xin, Xiaojie; Sun, Lei; Gao, Ming; Li, Qing; Wang, Dong

    2016-06-01

    Gastric cancer remains a disease with a high mortality rate despite of multiple therapeutic strategies. So far, it is very important to develop new treatment approaches to improve current therapeutic efficacy in gastric cancer. Apurinic/apyrimidinic endonuclease (APE1) involves in DNA base excision repair (BER) during DNA damage pathway. APE1 was found to be associated with poor overall survival with gastric cancer patients. In the in vitro experiment, we tested APE1 inhibitor-AT101 could potently inhibit gastric cancer cell growth and further induce cancer cell apoptosis and autophagy through p53-dependent pathway. Downregulation of APE1 by AT101 has ability to suppress gastric cancer cell migration and renewal through inhibition of CD133, Nanog and LC3expression. Based on findings that Her-2 positive expression cases has poor prognosis from our dataset and TCGA database, we investigated the role of AT101 in synergetic efficacy with 5-FU treatment in Her-2 overexpression gastric cancer in vivo, indicating that AT101 is able to enhance 5-FU in the shrinkage of xenograft mice tumor and induction of cell apoptosis. In summary, the data obtained from our study showed APE1 is guided as a potential therapeutic target for gastric cancer. AT101 could be regarded as a potent inhibitor to promote chemotherapeutic sensitivity in patients with gastric cancer.

  18. AT101 exerts a synergetic efficacy in gastric cancer patients with 5-FU based treatment through promoting apoptosis and autophagy

    Science.gov (United States)

    Wei, Xi; Duan, Wei; Li, Ying; Zhang, Sheng; Xin, Xiaojie; Sun, Lei; Gao, Ming; Li, Qing; Wang, Dong

    2016-01-01

    Gastric cancer remains a disease with a high mortality rate despite of multiple therapeutic strategies. So far, it is very important to develop new treatment approaches to improve current therapeutic efficacy in gastric cancer. Apurinic/apyrimidinic endonuclease (APE1) involves in DNA base excision repair (BER) during DNA damage pathway. APE1 was found to be associated with poor overall survival with gastric cancer patients. In the in vitro experiment, we tested APE1 inhibitor-AT101 could potently inhibit gastric cancer cell growth and further induce cancer cell apoptosis and autophagy through p53-dependent pathway. Downregulation of APE1 by AT101 has ability to suppress gastric cancer cell migration and renewal through inhibition of CD133, Nanog and LC3expression. Based on findings that Her-2 positive expression cases has poor prognosis from our dataset and TCGA database, we investigated the role of AT101 in synergetic efficacy with 5-FU treatment in Her-2 overexpression gastric cancer in vivo, indicating that AT101 is able to enhance 5-FU in the shrinkage of xenograft mice tumor and induction of cell apoptosis. In summary, the data obtained from our study showed APE1 is guided as a potential therapeutic target for gastric cancer. AT101 could be regarded as a potent inhibitor to promote chemotherapeutic sensitivity in patients with gastric cancer. PMID:27144437

  19. The Combination of the PARP Inhibitor Rucaparib and 5FU Is an Effective Strategy for Treating Acute Leukemias.

    Science.gov (United States)

    Falzacappa, Maria Vittoria Verga; Ronchini, Chiara; Faretta, Mario; Iacobucci, Ilaria; Di Rorà, Andrea Ghelli Luserna; Martinelli, Giovanni; Meyer, Lüder Hinrich; Debatin, Klaus-Michael; Orecchioni, Stefania; Bertolini, Francesco; Pelicci, Pier Giuseppe

    2015-04-01

    The existing treatments to cure acute leukemias seem to be nonspecific and suboptimal for most patients, drawing attention to the need of new therapeutic strategies. In the last decade the anticancer potential of poly ADP-ribose polymerase (PARP) inhibitors became apparent and now several PARP inhibitors are being developed to treat various malignancies. So far, the usage of PARP inhibitors has been mainly focused on the treatment of solid tumors and not too much about their efficacy on leukemias is known. In this study we test, for the first time on leukemic cells, a combined therapy that associates the conventional chemotherapeutic agent fluorouracil (5FU), used as a source of DNA damage, and a PARP inhibitor, rucaparib. We demonstrate the efficacy and the specificity of this combined therapy in killing both acute myeloid leukemia and acute lymphoid leukemia cells in vitro and in vivo. We clearly show that the inhibition of DNA repair induced by rucaparib is synthetic lethal with the DNA damage caused by 5FU in leukemic cells. Therefore, we propose a new therapeutic strategy able to enhance the cytotoxic effect of DNA-damaging agents in leukemia cells via inhibiting the repair of damaged DNA. ©2015 American Association for Cancer Research.

  20. Diversity of lactic acid bacteria in suan-tsai and fu-tsai, traditional fermented mustard products of Taiwan.

    Science.gov (United States)

    Chao, Shiou-Huei; Wu, Ruei-Jie; Watanabe, Koichi; Tsai, Ying-Chieh

    2009-11-15

    Fu-tsai and suan-tsai are spontaneously fermented mustard products traditionally prepared by the Hakka tribe of Taiwan. We chose 5 different processing stages of these products for analysis of the microbial community of lactic acid bacteria (LAB) by 16S rRNA gene sequencing. From 500 LAB isolates we identified 119 representative strains belonging to 5 genera and 18 species, including Enterococcus (1 species), Lactobacillus (11 species), Leuconostoc (3 species), Pediococcus (1 species), and Weissella (2 species). The LAB composition of mustard fermented for 3 days, known as the Mu sample, was the most diverse, with 11 different LAB species being isolated. We used sequence analysis of the 16S rRNA gene to identify the LAB strains and analysis of the dnaA, pheS, and rpoA genes to identify 13 LAB strains for which identification by 16S rRNA gene sequences was not possible. These 13 strains were found to belong to 5 validated known species: Lactobacillus farciminis, Leuconostoc mesenteroides, Leuconostoc pseudomesenteroides, Weissella cibaria, and Weissella paramesenteroides, and 5 possibly novel Lactobacillus species. These results revealed that there is a high level of diversity in LAB at the different stages of fermentation in the production of suan-tsai and fu-tsai.

  1. MicroRNA-302b Enhances the Sensitivity of Hepatocellular Carcinoma Cell Lines to 5-FU via Targeting Mcl-1 and DPYD.

    Science.gov (United States)

    Cai, Donghui; He, Kang; Chang, Su'e; Tong, Dongdong; Huang, Chen

    2015-10-06

    MiR-302b is a member of miR-302-367 cluster. The miR-302-367 cluster played important roles in maintaining pluripotency in human embryonic stem cells (hESCs) and has been proved to be capable of suppressing cell growth in several types of cancer cell lines including Hepatocellular Carcinoma (HCC) Cell lines. However, the role that miR-302b plays in the 5-Fluorouracil (5-FU) sensitivity of HCC has not been known. This study showed that miR-302b could enhance the sensitivity to 5-FU in HCC cell lines and verified its two putative targeted genes responsible for its 5-FU sensitivity.

  2. MicroRNA-302b Enhances the Sensitivity of Hepatocellular Carcinoma Cell Lines to 5-FU via Targeting Mcl-1 and DPYD

    Directory of Open Access Journals (Sweden)

    Donghui Cai

    2015-10-01

    Full Text Available MiR-302b is a member of miR-302-367 cluster. The miR-302-367 cluster played important roles in maintaining pluripotency in human embryonic stem cells (hESCs and has been proved to be capable of suppressing cell growth in several types of cancer cell lines including Hepatocellular Carcinoma (HCC Cell lines. However, the role that miR-302b plays in the 5-Fluorouracil (5-FU sensitivity of HCC has not been known. This study showed that miR-302b could enhance the sensitivity to 5-FU in HCC cell lines and verified its two putative targeted genes responsible for its 5-FU sensitivity.

  3. Slug-dependent upregulation of L1CAM is responsible for the increased invasion potential of pancreatic cancer cells following long-term 5-FU treatment.

    Directory of Open Access Journals (Sweden)

    Kaja Lund

    Full Text Available Pancreatic adenocarcinoma is a lethal disease with 5-year survival of less than 5%. 5-fluorouracil (5-FU is a principal first-line therapy, but treatment only extends survival modestly and is seldom curative. Drug resistance and disease recurrence is typical and there is a pressing need to overcome this. To investigate acquired 5-FU resistance in pancreatic adenocarcinoma, we established chemoresistant monoclonal cell lines from the Panc 03.27 cell line by long-term exposure to increasing doses of 5-FU.5-FU-resistant cell lines exhibited increased expression of markers associated with multidrug resistance explaining their reduced sensitivity to 5-FU. In addition, 5-FU-resistant cell lines showed alterations typical for an epithelial-to-mesenchymal transition (EMT, including upregulation of mesenchymal markers and increased invasiveness. Microarray analysis revealed the L1CAM pathway as one of the most upregulated pathways in the chemoresistant clones, and a significant upregulation of L1CAM was seen on the RNA and protein level. In pancreatic cancer, expression of L1CAM is associated with a chemoresistant and migratory phenotype. Using esiRNA targeting L1CAM, or by blocking the extracellular part of L1CAM with antibodies, we show that the increased invasiveness observed in the chemoresistant cells functionally depends on L1CAM. Using esiRNA targeting β-catenin and/or Slug, we demonstrate that in the chemoresistant cell lines, L1CAM expression depends on Slug rather than β-catenin.Our findings establish Slug-induced L1CAM expression as a mediator of a chemoresistant and migratory phenotype in pancreatic adenocarcinoma cells.

  4. La théorie du droit coutumier dans la recherche : ethnologie, théorie du droit et histoire du droit The theory of customary law in research: ethnology, legal theory and legal history

    Directory of Open Access Journals (Sweden)

    Ilia ch. Axionov

    2009-05-01

    Full Text Available Les auteurs cherchent à mettre de l’ordre dans la terminologie utilisée dans la science juridique, notamment à préciser les termes « coutume » et « droit coutumier ». En s’appuyant sur le droit romain classique et sur la théorie du droit ils passent en revue l’évolution des approches théoriques dans ce domaine en Russie ancienne et contemporaine. La ligne dominante chez les chercheurs russes était à souligner que ces coutumes n’acquièrent un caractère juridique que si elles reçoivent une protection de la part de l’Etat. L’article analyse aussi les travaux qui concernent la solution pratique de tels ou tels cas à l’aide des normes du droit coutumier tout en soulignant la nature sociale du droit coutumier.The authors try to bring coherence to terminology used in jurisprudence, especially through precise definitions for the terms « custom » and « customary law ». Relying on classical roman law and legal theory, they describe the evolution of theoretical approaches existing in this field in ancient and contemporary Russia. Russian scholars have generally agreed that these customs acquire a legal character only if they receive protection from the State. The article analyzes as well research proposing practical solutions of various cases which adopt the norms of customary law and while underlining the social nature of customary law.

  5. Vergleich der Imitation und Perzeption von Gesten der Finger, der Hand und des Fußes bei Patienten mit links- oder rechtszerebralen Läsionen

    OpenAIRE

    Strauß, Stefan

    2005-01-01

    Ziel der Arbeit ist es, ein bestehendes Modell zur Imitation von bedeutungslosen Gesten zu überprüfen und einen Test für die Imitation und Perzeption von Fußstellungen zu entwickeln, und in dieses Modell zu integrieren. Untersucht wurde prospektiv eine Stichprobe von 50 Patienten mit linkszerebralen (LZL) oder rechtszerebralen Läsionen (RZL) und 20 Kontrollpersonen. Patienten mit LZL haben bei der Imitation der Handstellungen mehr Schwierigkeiten als solche mit RZL, bei der Imitation der Fußs...

  6. Comparison of Targeting Distribution of PEG-5-Fu-MAMS and 5-Fu-MAMS in Pancreas under Magnetic Field%两种5-Fu磁性白蛋白微球对胰腺磁靶向性的比较

    Institute of Scientific and Technical Information of China (English)

    刘建刚; 刘志超; 孙诚谊; 钱志勇; 喻超; 王玉芝

    2007-01-01

    目的 比较磁导向下PEG修饰的5-氟尿嘧啶磁性白蛋白微球(PEG-5-Fu-MAMS)和5-氟尿嘧啶磁性白蛋白微球(5-Fu-MAMS)对胰腺的磁靶向性,以寻求一种对胰腺癌的磁导向化疗更有效的新途径.方法 取Wistar大鼠18只,每组6只,分为5-Fu组、5-Fu-MAMS组和PEG-5-Fu-MAMS组;分别将三种不同的制剂(按5-Fu 8mg/kg)经胃左动脉注入胃十二指肠动脉,进入循环.并在胰腺表面加一表面强度为4250GS的磁场,30min后,处死大鼠取胰腺.用HPLC法检测其药物浓度.结果 PEG-5-Fu-MAMS组胰腺中的药物浓度为76.18±4.09μg/ml;5-Fu-MAMS组为57.95±6.39μg/ml;5-Fu组为16.58±3.19μg/ml.PEG-5-Fu-MAMS组的药物浓度明显高于5-Fu-MAMS组和5-Fu组,差异具有显著统计学意义(P<0.01);5-Fu-MAMS组的药物浓度明显高于5-Fu组,差异具有显著统计学意义(P<0.01).结论 PEG修饰的磁性白蛋白微球具有更好的磁靶向性和亲水性,为实现胰腺癌的主动靶向治疗提供了一种新途径.

  7. Comparison of Targeting Distribution of PEG-5-Fu-MAMS and 5-Fu-MAMS in liver%两种5-氟尿嘧啶磁性白蛋白微球对肝脏靶向性的研究

    Institute of Scientific and Technical Information of China (English)

    刘志超; 刘建刚; 孔霞

    2010-01-01

    目的:研究聚乙二醇(PEG)修饰的5-氟尿嘧啶磁性白蛋白微球(PEG-5-5-Fu-MAMS)和5-氟尿嘧啶磁性白蛋白微球(5-Fu-MAMS)对肝脏的被动靶向性,为实现肿瘤的主动靶向治疗,减少化疗药物对肝脏的毒副作用寻找新的途径.方法:取Wistar大鼠侣只,每组6只,分为游离5-Fu组、5-Fu-MAMS组和PEG-5-Fu-MAMS组;分别将3种不同的制剂(按5-Fu 8 mg/kg)经尾静脉给药,30 min后,经眼眶采血,处死大鼠,取其肝脏.用高效液相色谱法(HPLC)法分别检测血液和肝脏中的药物浓度.结果:PEG-5-Fu-MAMS组、5-Fu-MAMS组和游离5-Fu组肝脏中的药物浓度分别为(25.21±2.98)μg/mL、(48.03±10.28)μg/mL和(15.31±2.81)μg/mL.PEG-5-Fu-MAMS组和5-Fu-MAMS组肝脏中药物浓度明显高于游离5-Fu组(P0.05).结论:PEG-5-Fu-MAMS对肝脏的被动靶向作用明显减弱,有效地减轻了药物对肝脏的毒副作用,为实现肿瘤的主动靶向治疗提供了一条新途径.

  8. Antimyosin antibody scintigraphy in patients treated with 5-fluorouracil (5-FU) and cis-platinum (CDDP); Scintigraphie aus anticorps antimyosine chez les patients traites par 5-fluorouracil (5-FU) et cis-platine (CDDP)

    Energy Technology Data Exchange (ETDEWEB)

    Muratet, J.P; Gameli, E.; Maillard, P.; Lortholary, A.; Delva, R.; Larra, P. [Centre Paul Papin, 2, rue Moll, 49033 Angers cedex 01 (France)

    1997-12-31

    The 5-FU in continuous perfusion over 96 h associated to CDDP can induce cardiac secondary effects for which a toxic myocardial origin is discussed. To locate anomalies related to myocarditis and consequently to adjust the dosing, a scintigraphy with antimyosin antibodies labelled with {sup 111}In (ScAM) was performed 7 days before the chemotherapy initiation and at the second day of it (with films at 4 d) in 14 patients, which besides benefited by clinical surveillance, ECG and FEVG (angio-scintigraphy before and at 48 h from the beginning of treatment). No clinical or ECG alteration and no significant variation of FEVG were found. The cardio-pulmonary fixation ratio (CPR) measured together with ScAM was not modified: 1.57 {+-} 0.21 [1.28 - 1.97] before treatment vs 1.54 {+-} 0.16 [1.30 - 1.90], during the treatment. The average intra-individual variation of CPR was as absolute value 8.12% {+-} 9.89% [0.60 - 29.71], only 2 patients presenting a variation larger than 20%. In absence, of clinical alteration, ECG or FEVG, the ScAM under 5-FU + CDDP does not show anomalies related to a asymptomatic myocardial affliction. Consequently, the exploration by ScAM appears to be reserved to symptomatic patients and/or to cases of asymptomatic break down by FEVG. Due to an inter-individual relatively limited dispersion of the values (m {+-} 2 ds 1.56 {+-} 0.37, in our series), establishing previously a reference individual CPR might be not indispensable

  9. Phase III trial of postoperative cisplatin, interferon alpha-2b, and 5-FU combined with external radiation treatment versus 5-FU alone for patients with resected pancreatic adenocarcinoma – CapRI: study protocol [ISRCTN62866759

    Directory of Open Access Journals (Sweden)

    Schmitz-Winnenthal H

    2005-04-01

    Full Text Available Abstract After surgical intervention with curative intention in specialised centres the five-year survival of patients with carcinoma of the exocrine pancreas is only 15%. The ESPAC-1 trial showed an increased five-year survival of 21% achieved with adjuvant chemotherapy. Investigators from the Virginia Mason Clinic have reported a 5-year survival rate of 55% in a phase II trial evaluating adjuvant chemotherapy, immunotherapy and external-beam radiation. Design The CapRI study is an open, controlled, prospective, randomised multi-centre phase III trial. Patients in study arm A will be treated as outpatients with 5-Fluorouracil; Cisplatin and 3 million units Interferon alpha-2b for 5 1/2 weeks combined with external beam radiation. After chemo-radiation the patients receive continuous 5-FU infusions for two more cycles. Patients in study arm B will be treated as outpatients with intravenous bolus injections of folinic acid, followed by intravenous bolus injections of 5-FU given on 5 consecutive days every 28 days for 6 cycles. A total of 110 patients with specimen-proven R0 or R1 resected pancreatic adenocarcinoma will be enrolled. An interim analysis for patient safety reasons will be done one year after start of recruitment. Evaluation of the primary endpoint will be performed two years after the last patients' enrolment. Discussion The aim of this study is to evaluate the overall survival period attained by chemo-radiotherapy including interferon alpha 2b administration with adjuvant chemotherapy. The influence of interferon alpha on the effectiveness of the patients' chemoradiation regimen, the toxicity, the disease-free interval and the quality of life are analysed. Different factors are tested in terms of their potential role as predictive markers.

  10. Regulated expression of a transgene introduced on an oriP/EBNA-1 PAC shuttle vector into human cells

    Directory of Open Access Journals (Sweden)

    Thorsen Jim

    2009-10-01

    Full Text Available Abstract Background Sequencing of the human genome has led to most genes being available in BAC or PAC vectors. However, limited functional information has been assigned to most of these genes. Techniques for the manipulation and transfer of complete functional units on large DNA fragments into human cells are crucial for the analysis of complete genes in their natural genomic context. One limitation of the functional studies using these vectors is the low transfection frequency. Results We have constructed a shuttle vector, pPAC7, which contains both the EBNA-1 gene and oriP from the Epstein-Barr virus allowing stable maintenance of PAC clones in the nucleus of human cells. The pPAC7 vector also contains the EGFP reporter gene, which allows direct monitoring of the presence of PAC constructs in transfected cells, and the Bsr-cassette that allows highly efficient and rapid selection in mammalian cells by use of blasticidin. Positive selection for recombinant PAC clones is obtained in pPAC7 because the cloning sites are located within the SacBII gene. We show regulated expression of the CDH3 gene carried as a 132 kb genomic insert cloned into pPAC7, demonstrating that the pPAC7 vector can be used for functional studies of genes in their natural genomic context. Furthermore, the results from the transfection of a range of pPAC7 based constructs into two human cell lines suggest that the transfection efficiencies are not only dependent on construct size. Conclusion The shuttle vector pPAC7 can be used to transfer large genomic constructs into human cells. The genes transferred could potentially contain all long-range regulatory elements, including their endogenous regulatory promoters. Introduction of complete genes in PACs into human cells would potentially allow complementation assays to identify or verify the function of genes affecting cellular phenotypes.

  11. Target Identification in Ory S1 Pollen Protein Allergen from Oryza sativa in the Course of Construction of Hypoallergenic Vaccines

    Directory of Open Access Journals (Sweden)

    Ruchi Sharma

    2009-01-01

    Full Text Available Problem statement: Recombinant-based approaches are mostly focused on genetic modification of allergens to produce molecules with reduced allergenic activity and conserved antigenicity, such as hypoallergens. Recombinant allergens represent promising tools for diagnosis and therapy of type I allergy. This approach was probably feasible with every allergen with known amino acid sequence. Approach: The primary aim of this study was to determine the consensus epitope from twenty homologous protein sequences of Ory S1 allergenic protein sequence from Oryza sativa (indica group pollen. Molecular modeling calculations had been used to investigate the allergenic protein models for the epitope. Results: Oryza sativa (japonica, Phleum pratense, Poa pratensis, Holcus lanatus, Lolium perenne, Triticum aestivum, Dactylis glomerata and Zea mays were found more closely related (alignment score 1145-812 among all the homologs and investigated further. The major binding pocket comprised an area of 604.5 Å2 and 970 Å3 volume and another key binding pocket had 425.6 Ų area and 658.8 ų volume. The residues found in the key site included ile2, lys13, cys14, ser15, lys16, pro17, ala25, leu26, ile27, tyr40, his41, phe42, asp43, leu44, ser45, gly46, leu47, ala48, met49, ala50, asp55, leu58, arg59, ala61, gly62, ile63, ile64, asp65, gln67, phe68; corresponding to the allergen binding site and the IgE binding epitope given in the title. Conclusion: These are the functional sites on the allergenic proteins that can be mutated to develop hypoallergenic vaccine. These sites can be rationalized on the basis of simple arguments that lead to vaccine development, by predicting the structure of the allergenic epitopes and comparative analysis.

  12. Accounting for Heritage, Cultural and Community Assets – Alternative Metrics from a New Zealand Māori Educational Institution

    Directory of Open Access Journals (Sweden)

    Susan Wild

    2013-03-01

    Full Text Available In the 1980s, with the rise to dominance of governments with neoliberal economic and social agendas, the public sector in major western countries underwent a process of fundamental reforms. A key aspect of the change imposed was the implementation of a market-oriented, cost-efficiency focus towards the management of public sector organisations, described collectively as the New Public Management (NPM model (Kelsey, 1995; Boston et al, 1996; Easton 1996; Barton, 2002, 2005a, 2005b; Carnegie & West, 2005; Ball & Grubnic, 2008; Davis, 2010. This reform process included the imposition of regulatory measures requiring public sector organisations to provide annual financial reports prepared on an accounting basis comparable to those for the private sector, and incorporated an obligation to disclose (at economic values all assets held. For public benefit entities holding heritage, cultural and community assets (HCA, this reporting requirement has been particularly problematic, entailing substantive changes to public accounting policy.This paper critiques the political ideologies and practices of the NPM model, and challenges its assumptions that private sector financial reporting requirements, based on international accounting standards and Generally Accepted Accounting Practice (GAAP, are appropriate for universal application to public benefit and other not-for-profit entities holding HCA. In particular, the paper argues against the NPM assumption that reporting all HCA in economic terms improves accountability in public benefit entities. Instead, the paper proposes an alternative reporting model based on a set of cultural rather than economic values for reporting HCA. It suggests as an exemplar the ‘Wellbeing of Communities’ reporting and accountability framework devised for application by an indigenous New Zealand Māori educational institution, Te Wānanga-o-Raukawa.

  13. Randomised trial comparing three different schedules of infusional 5FU and raltitrexed alone as first-line therapy in metastatic colorectal cancer. Final results of the Fédération Francophone de Cancérologie Digestive (FFCD) 9601 trial.

    Science.gov (United States)

    Ducreux, M; Bouche, O; Pignon, J P; Mousseau, M; Raoul, J L; Cassan, P; Leduc, B; Berger, C; Dunant, A; Fournet, J; Bedenne, L

    2006-01-01

    LV5FU2 with high-dose leucovorin (LV), weekly infusional 5-fluorouracil (5FU) (AIO schedule) and raltitrexed have been demonstrated to be active agents in first-line treatment of colorectal cancer. We performed a 4-arm randomised trial to compare (1) a low-dose intravenous bolus of LV (20 mg/m2), followed by an intravenous bolus of 5FU (400 mg/m2), followed by a 22-hour continuous infusion of 5FU (600 mg/m2) on day 1 and day 2/2 weeks (ldLV5FU2 arm), (2) a weekly continuous infusion of high-dose 5FU (2.6 g/m2/week) for 6 weeks followed by a rest week (HD-FU arm) and (3) raltitrexed (Tomudex arm; 3 mg/m2/3 weeks) to standard LV5FU2. From 1997 to 2001, 294 patients were included. The 4 arms were well balanced for sex ratio, age, WHO performance status, the primary tumour site and prior adjuvant chemotherapy. Treatment was stopped due to low accrual. Two toxicity-related deaths were observed in the Tomudex arm. The treatments gave rise to different rates of grade 3-4 neutropenia (3, 4, 11 and 14% of the patients in the LV5FU2, ldLV5FU2, HD-FU and Tomudex arms, respectively, p = 0.028), leucopenia and vomiting. At least one episode of grade 3-4 toxicity was observed in 27, 25, 38 and 47% of the patients in the LV5FU2, ldLV5FU2, HD-FU and Tomudex arms, respectively (p = 0.016). An objective response was observed in 28, 21, 22 and 10% of the patients in the LV5FU2, ldLV5FU2, HD-FU and Tomudex arms, respectively (p = 0.04). Progression-free survival (PFS) of the patients in the Tomudex arm was statistically lower compared to that of patients treated with LV5FU2 or ldLV5FU2 (combined group; p = 0.013, log rank test). In conclusion, Tomudex is more toxic and yields shorter PFS than infusional 5FU. Despite the early closure of the study and the lack of power of the comparison, it seems that ldLV5FU2 could be considered as an active, easier and less expensive option for the treatment of metastatic colorectal cancer compared to classic LV5FU2 or weekly HD-FU.

  14. A New Arthropod, Guangweicaris Luo, Fu et Hu gen. nov.from the Early Cambrian Guanshan Fauna, Kunming, China

    Institute of Scientific and Technical Information of China (English)

    LUO Huilin; FU Xiaoping; HU Shixue; LI Yong; HOU Shuguang; YOU Ting; PANG Jiyuan; LIU Qi

    2007-01-01

    The Guanshan Fauna is a soft-bodied fauna dominated by arthropods (including trilobites,trilobitoides, Tuzoia, Isoxys, and bradorids) in association with priapulids, brachiopods,anomalocaridids, vetulicoliids, sponges, chancellorids, and echinoderms. This paper reports and describes a new arthropod from the yellowish green mudstone at the lower part of the Wulongqing Formation, Canglangpuan Stage, Lower Cambrian in Kunming, Yunnan, China. The stratigraphic and geographic distribution, classification, fossil preservation, life style of this new arthropod and comparisons with other fossil arthropods are also discussed in details. The discovery and research of the non-mineralized arthropod, Guangweicaris Luo, Fu et Hu gen. nov. from the Guanshan Fauna adds new members to the taxonomic list and provides new information to the evolution of early arthropods.Furthermore, this study would shed new light into the "Cambrian Explosion" and the evolution of early life.

  15. The Sentimental Feelings in Cao Pi's Fu%论曹丕赋中的感伤情怀

    Institute of Scientific and Technical Information of China (English)

    张靖

    2012-01-01

    曹丕的赋具有很强的抒情性,由于特殊的政治地位和人生遭遇,使得曹丕在其赋中流露出凄凉哀婉的心境,以及孤立无援的精神状态,展现了曹丕精神世界中敏感脆弱的一面。%Cao Pi' s Fu has strong lyricism due to the special political status and life experience. Cao Pi in his ode re- veals the desolate pathos mood, as well as the isolated and helpless mental state, which shows Cao Pi' s spiritual world of fragile and sensitive side.

  16. 试论沈光文《台湾赋》%A Trial Discussion on Taiwan Fu by Shen Guangwen

    Institute of Scientific and Technical Information of China (English)

    袁韵

    2016-01-01

    沈光文的《台湾赋》是台湾赋体文学的开山之作,因其对台湾历史、地理、物产、民俗等的全方位反映,而有“第一部台湾简史”之誉,具有珍贵的史料价值。《台湾赋》对荷兰殖民者入侵历史的痛斥,对郑成功金陵之役、驱荷复台之役的客观评价,都反映了作者进步的历史观;其对郑经的批评,则反映了作为鲁王侍臣的沈光文对封建礼法正统性的维护。%Shen Guangwen’ s Taiwan Fu is the groundbreaking work of the Taiwan ode literature,which is honored as“The first brief history of Taiwan” with great documentary value based on its comprehensive re⁃flection on Taiwan history,geography,property and folk customs. Taiwan Fu reflects the author’s progressive historical viewpoint and political attitude in terms of not only the denunciation of the invasion history of the Dutch colonialists,but also the evaluation of Jinling battle and recapture battle led by Zheng Chenggong.The criticism of Zheng Jing reflects the maintenance of the legitimacy of feudal etiquette based on Shen Guangwen’s identity as the courtier of Lu Wang.

  17. Calculating clear-sky radiative heating rates using the Fu-Liou RTM with inputs from observed and reanalyzed profiles

    Science.gov (United States)

    Dolinar, E. K.; Dong, X.; Xi, B.

    2015-12-01

    One-dimensional radiative transfer models (RTM) are a common tool used for calculating atmospheric heating rates and radiative fluxes. In the forward sense, RTMs use known (or observed) quantities of the atmospheric state and surface characteristics to determine the appropriate surface and top-of-atmosphere (TOA) radiative fluxes. The NASA CERES science team uses the modified Fu-Liou RTM to calculate atmospheric heating rates and surface and TOA fluxes using the CERES observed TOA shortwave (SW) and longwave (LW) fluxes as constraints to derive global surface and TOA radiation budgets using a reanalyzed atmospheric state (e.g. temperature and various greenhouse gases) from the newly developed MERRA-2. However, closure studies have shown that using the reanalyzed state as input to the RTM introduces some disparity between the RTM calculated fluxes and surface observed ones. The purpose of this study is to generate a database of observed atmospheric state profiles, from satellite and ground-based sources, at several permanent Atmospheric Radiation Measurement (ARM) Program sites, including the Southern Great Plains (SGP), Northern Slope of Alaska (NSA) and Tropical Western Pacific Nauru (TWP-C2), and Eastern North Atlantic (ENA) permanent facilities. Since clouds are a major modulator of radiative transfer within the Earth's atmosphere, we will focus on the clear-sky conditions in this study, which will set up the baseline for our cloudy studies in the future. Clear-sky flux profiles are calculated using the Edition 4 NASA LaRC modified Fu-Liou RTM. The aforementioned atmospheric profiles generated in-house are used as input into the RTM, as well as from reanalyses. The calculated surface and TOA fluxes are compared with ARM surface measured and CERES satellite observed SW and LW fluxes, respectively. Clear-sky cases are identified by the ARM radar-lidar observations, as well as satellite observations, at the select ARM sites.

  18. Ultrasound-activated agents comprised of 5FU-bearing nanoparticles bonded to microbubbles inhibit solid tumor growth and improve survival.

    Science.gov (United States)

    Burke, Caitlin W; Alexander, Eben; Timbie, Kelsie; Kilbanov, Alexander L; Price, Richard J

    2014-02-01

    Nanoparticle (NP) drug delivery vehicles may eventually offer improved tumor treatments; however, NP delivery from the bloodstream to tumors can be hindered by poor convective and/or diffusive transport. We tested whether poly(lactic-co-glycolic acid) NP delivery can be improved by covalently linking them to ultrasound (US)-activated microbubbles in a "composite-agent" formulation and whether drug 5-fluorouracil (5FU)-loaded NPs delivered in this fashion inhibit the growth of tumors that are typically not responsive to intravenously administered 5FU. After intravenous composite-agent injection, C6 gliomas implanted on Rag-1(-/-) mice were exposed to pulsed 1 MHz US, resulting in the delivery of 16% of the initial NP dose per gram tissue. This represented a five- to 57-fold increase in NP delivery when compared to multiple control groups. 5FU-bearing NP delivery from the composite-agent formulation resulted in a 67% reduction in tumor volume at 7 days after treatment, and animal survival increased significantly when compared to intravenous soluble 5FU administration. We conclude that NP delivery from US-activated composite agents may improve tumor treatment by offering a combination of better targeting, enhanced payload delivery, and controlled local drug release.

  19. Modulation of thymidilate synthase and p53 expression by HDAC inhibitor vorinostat resulted in synergistic antitumor effect in combination with 5FU or raltitrexed.

    Science.gov (United States)

    Di Gennaro, Elena; Bruzzese, Francesca; Pepe, Stefano; Leone, Alessandra; Delrio, Paolo; Subbarayan, Pochi R; Avallone, Antonio; Budillon, Alfredo

    2009-05-01

    Despite the introduction of several novel anticancer agents almost 50% of colorectal cancer (CRC) patients die for cancer suggesting the necessity of new therapeutical approaches. In this study we demonstrated that the HDAC inhibitor vorinostat exerted potent antiproliferative effect in a panel of mut- and wt-p53 human CRC cell lines. Moreover, in combination with 5-fluorouracil modulated by folinic acid (5FU-FA) or with Raltitrexed (RTX), both commonly used in the treatment of this disease, it showed a clear schedule-dependent synergistic antiproliferative interaction as demonstrated by calculating combination indexes. Only simultaneous, or 24 h pretreatment with vorinostat followed by either agent, produced synergistic effect paralleled by evident cell cycle perturbations with major S-phase arrest. Moreover, we provided for the first time evidences that vorinostat can overcome resistance to both 5FU and RTX. Downmodulation of Thymidilate synthase (TS) protein induced by vorinostat within 24 h, represented a key factor in enhancing the effects of both drugs in sensitive as well as resistant tumor cells. Furthermore, p53, whose wild-type expression is critical for sensitivity to 5FU and RTX, was upregulated by vorinostat in wt- and downregulated in mut-p53 cells, suggesting an additional mechanism of the antiproliferative synergistic interactions observed. Overall these data add new insights in the mechanism of vorinostat antitumor effect and suggested that the association of vorinostat plus 5FU-FA and/or RTX should be clinically explored.

  20. 傅山医事和医学著述略考%Research on Medical Events and Medical Writings of Fu Shan

    Institute of Scientific and Technical Information of China (English)

    郑梅玲

    2016-01-01

    Fu Shan, a famous thinker, painter, poet and doctor in the Ming and Qing dynasties, is an expert in medicine and medical theories, and invented effective formulae for disease treatment. He had great achievements in gynecology, andrology, pediatrics, obstetrics, etc. This article combed the existing medical writings of Fu Shan by organizing recordings of medical events of FU Shan in historical literature, and expounded the important achievements of Fu Shan made to TCM.%傅山是明清之际著名的思想家、书画家、诗人和医生。他精通医学医理,治验有奇方,在女科、男科、儿科、产科等都有建树。本文通过整理历史文献中对傅山医事的记载,梳理其流传在世的医学著述,阐述傅山对中医学的重要贡献。

  1. 制度视野下的辞赋创作——以清代乾嘉时期为中心%Fu Writing in Perspective of Institution: a Case Study of Qianlong and Jiaqing Periods in Qing Dynasty

    Institute of Scientific and Technical Information of China (English)

    孙福轩

    2012-01-01

    清代是古代赋学的集大成期,无论是辞赋创作还是赋论都有十分重要的历史地位。赋学的繁荣除了统治者的辞赋创作与提倡外,科举试赋也是一个十分重要的因素,特别是乾嘉时期,针对律赋创作的疲苶倾向,赋论家提出"以古文为时文"的创作要求,既是辞赋文体自身的救赎,也是应合科举试赋的统治阶级意向的表现,对后期辞赋创作及古代赋学理论产生了积极的影响,而赋论强调"丽则"的观念也可以说是统治政策在文体风格方面的必然反映。%The Qing Dynasty plays an important role in Fu writing and study in ancient China.Besides ruler' s Fu writing and promotion,Fu test in imperial examinations is main factor to prosper Fu study.In Qianlong and Jiaqing periods,the writing of rhymed Fu was sluggish and Fu researchers proposed a requirement by taking ancient Chinese literary style as style of that time.This is not only the salvation of the style of Fu,but also a demonstration to respond the will of the ruling class of examining Fu in imperial examinations.This trend plays a positive role in later Fu writing and ancient Fu theory.The idea of stressing the principle for beauty can be regarded as a necessary reflection of rule policy in literary style.

  2. Théorie visco-élastique non-extensive IV. Premiers tests expérimentaux de la théorie simplifiée à modes translationnels

    Science.gov (United States)

    Volino, F.

    This paper describes the first tests of the non-extensive visco-elastic theory with translational modes developed in (III), using viscosity, self-diffusion, shear elasticity, thermal conductivity and surface tension literature data of several liquids, namely water, organic solvents and a nematics, for which numerous data exist in the literature. As in the rotational case (I, II), a remarkable qualitative and quantitative agreement is obtained. The influence of translational-rotational coupling on the flow is examined for the nematics and for water. The obtained results, of equivalent importance as those obtained previouly in (II), are more spectacular in the sense that they concern more common substances. If the proposed description is accepted, important changes in the meaning of some physical concepts are necessarily implied. Cet article décrit les premiers tests de la théorie visco-élastique non-extensive à modes translationnels développée dans l'article (III), à l'aide de données de viscosité, de coefficients d'auto-diffusion, d'élasticité de cisaillement, de conductivité thermique et de tension superficielle, d'un certain nombre de liquides, à savoir l'eau, des solvants organiques usuels et un nématique, pour lesquels de très nombreuses données expérimentales existent dans la littérature. Comme dans le cas rotationnel avec les nématiques (I, II), un accord qualitatif et surtout quantitatif remarquable est obtenu. L'influence du couplage translation-orientation sur les propriétés d'écoulement est examiné dans le cas du nématique, et dans une certaine mesure, de l'eau. Ces résultats, de même importance absolue que ceux obtenus dans (II) avec les aspects rotationnels, sont relativement plus spectaculaires dans la mesure où ils sont relatifs à des substances beaucoup plus communes. Si ce type de description est accepté, ils impliquent inévitablement des changements importants sur la signification de certains concepts physiques.

  3. Requirement of the N-terminal residues of human cytomegalovirus UL112-113 proteins for viral growth and oriLyt-dependent DNA replication.

    Science.gov (United States)

    Kim, Young-Eui; Park, Mi Young; Kang, Kyeong Jin; Han, Tae Hee; Lee, Chan Hee; Ahn, Jin-Hyun

    2015-08-01

    The UL112-113 region of the human cytomegalovirus (HCMV) genome encodes four phosphoproteins of 34, 43, 50, and 84 kDa that promote viral DNA replication. Co-transfection assays have demonstrated that self-interaction of these proteins via the shared N-termini is necessary for their intranuclear distribution as foci and for the efficient relocation of a viral DNA polymerase processivity factor (UL44) to the viral replication sites. However, the requirement of UL112-113 N-terminal residues for viral growth and DNA replication has not been fully elucidated. Here, we investigated the effect of deletion of the N-terminal regions of UL112-113 proteins on viral growth and oriLyt-dependent DNA replication. A deletion of the entire UL112 region or the region encoding the 25 N-terminal amino-acid residues from the HCMV (Towne strain) bacmid impaired viral growth in bacmid-transfected human fibroblast cells, indicating their requirement for viral growth. In co-immunoprecipitation assays using the genomic gene expressing the four UL112-113 proteins together, the 25 N-terminal amino-acid residues were found to be necessary for stable expression of UL112-113 proteins and their self-interaction. These residues were also required for efficient binding to and relocation of UL44, but not for interaction with IE2, an origin-binding transcription factor. In co-transfection/replication assays, replication of the oriLyt-containing plasmid was promoted by expression of intact UL112-113 proteins, but not by the expression of 25-amino-acid residue-deleted proteins. Our results demonstrate that the 25 N-terminal amino-acid residues of UL112-113 proteins that mediate self-interaction contribute to viral growth by promoting their binding to UL44 and the initiation of oriLyt-dependent DNA replication.

  4. Combined 5-FU and ChoKα inhibitors as a new alternative therapy of colorectal cancer: evidence in human tumor-derived cell lines and mouse xenografts.

    Directory of Open Access Journals (Sweden)

    Ana de la Cueva

    Full Text Available BACKGROUND: Colorectal cancer (CRC is the third major cause of cancer related deaths in the world. 5-fluorouracil (5-FU is widely used for the treatment of colorectal cancer but as a single-agent renders low response rates. Choline kinase alpha (ChoKα, an enzyme that plays a role in cell proliferation and transformation, has been reported overexpressed in many different tumors, including colorectal tumors. ChoKα inhibitors have recently entered clinical trials as a novel antitumor strategy. METHODOLOGY/PRINCIPAL FINDINGS: ChoKα specific inhibitors, MN58b and TCD-717, have demonstrated a potent antitumoral activity both in vitro and in vivo against several tumor-derived cell line xenografts including CRC-derived cell lines. The effect of ChoKα inhibitors in combination with 5-FU as a new alternative for the treatment of colon tumors has been investigated both in vitro in CRC-tumour derived cell lines, and in vivo in mouse xenografts models. The effects on thymidilate synthase (TS and thymidine kinase (TK1 levels, two enzymes known to play an essential role in the mechanism of action of 5-FU, were analyzed by western blotting and quantitative PCR analysis. The combination of 5-FU with ChoKα inhibitors resulted in a synergistic effect in vitro in three different human colon cancer cell lines, and in vivo against human colon xenografts in nude mice. ChoKα inhibitors modulate the expression levels of TS and TK1 through inhibition of E2F production, providing a rational for its mechanism of action. CONCLUSION/SIGNIFICANCE: Our data suggest that both drugs in combination display a synergistic antitumoral effect due to ChoKα inhibitors-driven modulation of the metabolization of 5-FU. The clinical relevance of these findings is strongly supported since TCD-717 has recently entered Phase I clinical trials against solid tumors.

  5. E2F1/TS Immunophenotype and Survival of Patients with Colorectal Cancer Treated with 5FU-Based Adjuvant Therapy.

    Science.gov (United States)

    Sulzyc-Bielicka, Violetta; Domagala, Pawel; Bielicki, Dariusz; Safranow, Krzysztof; Rogowski, Wojciech; Domagala, Wenancjusz

    2016-07-01

    The predictive value of thymidylate synthase (TS) expression alone for 5FU-based treatment of colorectal cancer (CRC) has not been clinically confirmed. Little is known on the association of expression of E2F1, which controls the transcription of genes encoding proteins engaged in DNA synthesis including TS, and survival of patients with CRC. The purpose of this study is to assess the correlation between expression of both E2F1 and TS in CRCs and survival of patients administered adjuvant 5FU-based chemotherapy, in order to find a better predictor of treatment outcome than expression of TS or E2F1 alone. Nuclear TS and E2F1 were detected by immunohistochemistry in tissue microarrays from 190 CRCs (Astler-Coller stage B2 or C). Multivariate analysis identified significant association of the combined E2F1+TS+ immunophenotype with worse OS (HR = 3,78, P = 0,009) and DFS (HR = 2,30, P = 0,03) of patients with colon cancer. There were significant differences between E2F1+TS+ and E2F1-TS- Kaplan-Meier survival curves in relation to DFS (P = 0.008) and OS (P = 0.01). About 37 and 31 % difference in 3-year DFS and OS respectively were seen between patients with E2F1+TS+ vs. E2F1-TS- colon cancer immunophenotype. The E2F1+TS+ immunophenotype may be a marker of poor prognosis (the worst DFS and OS) of patients with colon cancer treated with 5FU-based adjuvant therapy. A subgroup of patients with this immunophenotype may require different and perhaps more aggressive treatment than 5FU-based chemotherapy. Thus, the combined E2F1/TS immunophenotype could be a potential indicator of colon cancer sensitivity to 5FU.

  6. [Effects of intravenous alimentation on adjuvant chemotherapy--an experimental study on the distribution of 5-FU after injection of tegafur (2)].

    Science.gov (United States)

    Kimoto, M; Nagano, H; Sano, K

    1987-10-01

    The stomach, small and large intestines, heart, lungs, bone and kidneys were removed from 48 Sato lung cancer-bearing rats used in the previous experiments and given 90 mg/kg of tegafur (FT-207) by single intravenous administration and tissue 5-FU and FT-207 concentrations were measured. FT-207 concentration in the alimentary canal was somewhat lower than the blood concentration, but both were lowered in parallel. 5-FU concentration in the stomach and large intestines showed virtually identical changes in both IVH and PO groups, but IVH group tended to have higher concentration. IVH group showed higher values than PO group anytime, particularly in the large intestines. A reduction of the side effects on the digestive system via intravenous alimentation was thought due to the elimination of mechanical stimulation via a cessation of oral feeding. 5-FU concentration in the bone was highest in PO group at six hours after administration and blood concentration changes were parallel, but there was virtually no change in IVH group. Maximum values were found one hour after administration and slowly declined thereafter; at 24 hrs the values were 0.059 +/- 0.013 microgram/g, relatively high compared to the PO group at 0.041 +/- 0.022 microgram/g. In the present study under intravenous alimentation, the concentration changes were slight in spite of 5-FU maximum concentration being lower than that by oral feeding and the long-term high concentration which was maintained; this is thought to be a disadvantageous action with regard to the bone marrow. FT-207 concentration in the kidney, heart and lungs was the same as that for the blood, with a gradual reduction in IVH group. 5-FU concentration was the same for the kidneys and IVH group quickly reached to the high levels compared to PO group with only slight changes thereafter. Effects of continuous water load might be involved but not clear.

  7. 赋之比喻审美发展演变论%A Study of Parable Aesthetic Developments in Fu(赋)

    Institute of Scientific and Technical Information of China (English)

    冯广艺; 何婷婷

    2016-01-01

    赋是我国古代特色鲜明的一种文体,兴盛于汉代,衰落于近代。从比喻审美的角度看,汉赋中的比喻能够再现自然美,籦丽铺排,讲求修饰,辞藻华丽,气势恢宏,具有宏丽美。魏晋南北朝时期,赋中比喻突出自然美,彰显内容美,具有形象美。唐宋时期,赋中比喻凸显通俗美、情感美和形式美。金元明清时期,赋中比喻巧妙选择喻体,突出形象美;寓情于景,抒发情怀,具有情意美;比喻与其他辞格合用,结构精巧,富有形式美。%Fu(赋)is a kind of style of Chinese ancient times,which flourished in the Han Dynasties and declined in modern times.The parables in the Han Fu(赋)reproduced natural beauty,emphasized the modi-fications and rhetoric.They were magnificent,and they were provided with gorgeous beauty.During the period of the Wei,Jin and Southern and Northern Dynasties,the parables in Fu(赋)had natural beauty,content beauty and image beauty.The Tang and Song Dynasties,the parables in Fu displayed popular beauty,emo-tional beauty and formal beauty.The Jin,Yuan,Ming and Qing Dynasties,the parables in Fu showed image beauty,cordial beauty and formal beauty.

  8. Reconnaissance d’expressions faciales chez des personnes atteintes du syndrome de Moebius Mise à l’épreuve des théories motrices de la perception

    OpenAIRE

    Louppe, Elisabeth

    2017-01-01

    Les expressions faciales constituent une source d'informations importante pour connaître l'état émotionnel des autres et anticiper leurs intentions à notre égard. Dans ce contexte, il est donc essentiel de comprendre quels sont les mécanismes à la base de cette capacité de reconnaissance. Selon certaines théories de la simulation sensori-motrice, les neurones activés lors de la production des expressions faciales sont indispensables dans la reconnaissance de ces mêmes expressions. Suivant cet...

  9. Trente années qui ébranlèrent la physique histoire de la théorie quantique

    CERN Document Server

    Gamow, George

    1968-01-01

    G. Gamow, dans cet ouvrage, déploie une fois encore ses qualités d'historien, de vulgarisateur et d'homme d'esprit. L'"histoire de la théorie quantique" raconte la naissance de la physique moderne au cours des trente premières années du siècle, en nous guidant ainsi à travers cette galerie de portraits où les grands noms de la physique sont présentés, par les textes, les photographies et les croquis, sous leur aspect le moins académique.

  10. Hypnose, sommeil, placebo ? : Les réponses de la Théorie neuronale de la Cognition – Tome 2

    OpenAIRE

    Touzet, Claude

    2014-01-01

    International audience; Initialement uniquement dédié aux quelques « faits » comme :l'hypnose, le plaisir, le sommeil et les rêves, la responsabilité, l'effet placebo et la schizophréniequi n'avaient pas reçu d'explications de la part de la Théorie neuronale de la Cognition (tome 1 – Conscience, intelligence, libre-arbitre), ce second opus a rapidement dévié de sa mission originale pour intégrer des aspects encore plus controversés, comme :- le paranormal,- l'influence de l'intention sur la r...

  11. Stable replication of the EBNA1/OriP-mediated baculovirus vector and its application to anti-HCV gene therapy

    Directory of Open Access Journals (Sweden)

    Chang Myint OO

    2009-10-01

    Full Text Available Abstract Background Hepatitis C virus (HCV is one of the main causes of liver-related morbidity and mortality. Although combined interferon-α-ribavirin therapy is effective for about 50% of the patients with HCV, better therapies are needed and preventative vaccines have yet to be developed. Short-hairpin RNAs (shRNAs inhibit gene expression by RNA interference. The application of transient shRNA expression is limited, however, due to the inability of the shRNA to replicate in mammalian cells and its inefficient transduction. The duration of transgene (shRNA expression in mammalian cells can be significantly extended using baculovirus-based shRNA-expressing vectors that contain the latent viral protein Epstein-Barr nuclear antigen 1 (EBNA1 and the origin of latent viral DNA replication (OriP sequences. These recombinant vectors contain compatible promoters and are highly effective for infecting primary hepatocyte and hepatoma cell lines, making them very useful tools for studies of hepatitis B and hepatitis C viruses. Here, we report the use of these baculovirus-based vector-derived shRNAs to inhibit core-protein expression in full-length hepatitis C virus (HCV replicon cells. Results We constructed a long-term transgene shRNA expression vector that contains the EBV EBNA1 and OriP sequences. We also designed baculovirus vector-mediated shRNAs against the highly conserved core-protein region of HCV. HCV core protein expression was inhibited by the EBNA1/OriP baculovirus vector for at least 14 days, which was considerably longer than the 3 days of inhibition produced by the wild-type baculovirus vector. Conclusion These findings indicate that we successfully constructed a long-term transgene (shRNA expression vector (Ac-EP-shRNA452 using the EBNA1/OriP system, which was propagated in Escherichia coli and converted into mammalian cells. The potential anti-HCV activity of the long-term transgene (shRNA expression vector was evaluated with the view

  12. Nietzsche : les Lumières et la cruauté. De l’interprétation de Nietzsche par la Théorie critique

    Directory of Open Access Journals (Sweden)

    Agnès Gayraud

    2010-09-01

    Full Text Available En 1983, dans Le Discours philosophique de la modernité, la critique habermassienne de l’irrationalisme et du poststructuralisme fait basculer sans équivoque l’auteur de La Volonté de puissance dans le camp des ennemis de la Théorie critique. Toutefois, à la faveur peut-être d’une lecture qui se voulait celle de happy few, les fondateurs de la Théorie critique, Max Horkheimer et Theodor W. Adorno, n’avaient jusque-là pas fait de Friedrich Nietzsche une figure aussi menaçante. Lors d’un entretien radiophonique consacré au philosophe, enregistré à Francfort-sur-le-Main le 31 juillet 1950 en célébration du cinquantième anniversaire de sa mort, ils dénoncèrent l’« horrible mécompréhension » dont Nietzsche avait surtout fait l’objet. Par leur attention à l’ironie de Nietzsche, à la négativité de son discours, ils avaient toujours décelé dans sa pensée de la cruauté le nerf d’une pensée des Lumières telle qu’elle devait être encore affirmée au xxe siècle. Aurait-il existé une alliance paradoxale de la Théorie critique avec le théoricien du Surhomme et de l’Éternel retour, avant qu’avec Habermas la guerre ne lui soit déclarée, ainsi qu’à ses héritiers ? L’article tente de faire apparaître comment, avant cette guerre – et n’en déplaise également aux ennemis nietzschéens de la dialectique –, existait entre Nietzsche et la Théorie critique plus et mieux qu’un statu quo.

  13. Noma (cancrum oris).

    Science.gov (United States)

    Enwonwu, Cyril O; Falkler, William A; Phillips, Reshma S

    2006-07-01

    Noma is an opportunistic infection promoted by extreme poverty. It evolves rapidly from a gingival inflammation to grotesque orofacial gangrene. It occurs worldwide, but is most common in sub-Saharan Africa. The peak incidence of acute noma is at ages 1-4 years, coinciding with the period of linear growth retardation in deprived children. Noma is a scourge in communities with poor environmental sanitation. It results from complex interactions between malnutrition, infections, and compromised immunity. Diseases that commonly precede noma include measles, malaria, severe diarrhoea, and necrotising ulcerative gingivitis. The acute stage responds readily to antibiotic treatment. The sequelae after healing include variable functional and aesthetic impairments, which require reconstructive surgery. Noma can be prevented through promotion of national awareness of the disease, poverty reduction, improved nutrition, promotion of exclusive breastfeeding in the first 3-6 months of life, optimum prenatal care, and timely immunisations against the common childhood diseases.

  14. Effects of Artemis on DNA damage of human hepatic carcinoma cell line BEL-7402/5FU%Artemis对人肝癌细胞系BEL-7402/5FU DNA损伤的影响

    Institute of Scientific and Technical Information of China (English)

    张雪; 李大玉; 祝小波; 范芳; 刘云; 李长福

    2016-01-01

    目的 探讨转染shArtemis干扰质粒对人肝癌细胞BEL-7402/5FU DNA损伤的影响.方法 将人肝癌细胞分为正常对照组、脂质体对照组、空质粒对照组和转染shArtemis干扰质粒实验组(shArtemis实验组);建立DNA损伤模型,分别用0.625、1.25、2.5、5.0和10.0 μg/mL的丝裂霉素C作用BEL-7402/5FU细胞24和48 h,MTT法检测细胞活性,Western blot观察磷酸化组蛋白H2AX(γ-H2AX)的表达;转染Artemis干扰质粒,检测Artemis、γ-H2AX表达;彗星实验检测DNA的损伤.结果 0.625、1.25、2.5、5.0和10.0 μg/mL的丝裂霉素C作用48h后肝癌细胞活力明显下降(P<0.05);丝裂霉素C刺激细胞48 h后,γ-H2AX的表达量随着药物浓度的增加而增加;转染shArtemis干扰质粒后,γ-H2AX的表达量较正常对照组增加(P<0.05);shArtemis实验组较正常对照组拖尾DNA量增加(P<0.05).结论 丝裂霉素C能够诱导肝癌细胞损伤;转染shArtemis干扰质粒促进丝裂霉素C诱导的人肝癌细胞BEL-7402/5FU DNA损伤.

  15. Conference overview of "Academic seminar for commemorating the 1 300th birthday of DU Fu and the 6th annual conference of Chinese seminar of DU Fu"%“纪念杜甫诞生1300周年学术研讨会暨中国杜甫研究会第六届年会”会议综述

    Institute of Scientific and Technical Information of China (English)

    姜一慧; 张倩

    2012-01-01

    为纪念诗圣杜甫诞生1300周年,各地专家学者在古都西安隆重集会。会议议题涉及杜甫的生平和思想与创作、杜诗学、杜诗研究与当下诗词创作、域外杜诗研究、杜甫与长安、杜诗与长安文化等。会议的学术研讨集中体现了以下几大特色:时代气息,文化研究;最新成果,集中展示;命题集中,亮点突出;回归学术,精神传承。%DU Fu was a great poet in the history of China and even the world. In order to commemorate the 1 300th birthday of the spoet-sage, scholars from various places held a conference in the ancient cap- ital Xi'an. The topics of the conference involved the lifetime, thoughts and works of DU Fu, studies on DU Fu's poems, current poetry creation, foreign studies on DU Fu's poems, DU Fu and Chang'an, and DU Fu's poems and Chang'an culture, etc. The following characteristics were reflected by the conference, including the spirit of the times and the cultural studies; intensive display of the latest achievement; the centralized topics with highlights and academic return with spirit inheritance.

  16. A DPYD variant (Y186C) specific to individuals of African descent in a patient with life-threatening 5-FU toxic effects: potential for an individualized medicine approach.

    Science.gov (United States)

    Saif, Muhammad Wasif; Lee, Adam M; Offer, Steven M; McConnell, Kathleen; Relias, Valerie; Diasio, Robert B

    2014-01-01

    5-Fluorouracil (5-FU) is commonly administered as a therapeutic agent for the treatment of various aggressive cancers. Severe toxic reactions to 5-FU have been associated with decreased levels of dihydropyrimidine dehydrogenase (DPD) enzyme activity. Manifestations of 5-FU toxicity typically include cytopenia, diarrhea, stomatitis, mucositis, neurotoxicity, and, in extreme cases, death. A variety of genetic variations in DPYD, the gene encoding DPD, are known to result in decreased DPD enzyme activity and to contribute to 5-FU toxic effects. Recently, it was reported that healthy African American individuals carrying the Y186C DPYD variant (rs115232898) had significantly reduced DPD enzyme activity compared with noncarriers of Y186C. Herein, we describe for the first time, to our knowledge, an African American patient with cancer with the Y186C variant who had severe toxic effects after administration of the standard dose of 5-FU chemotherapy. The patient lacked any additional toxic effect-associated variations in the DPYD gene or the thymidylate synthase (TYMS) promoter. This case suggests that Y186C may have contributed to 5-FU toxicity in this patient and supports the use of Y186C as a predictive marker for 5-FU toxic effects in individuals of African ancestry.

  17. 茯砖茶茶汤稳定性研究%Study on Stability of Fu-brick Tea Infusion

    Institute of Scientific and Technical Information of China (English)

    黄亚亚; 梁艳; 邓永亮; 陈桂梅; 纪晓明; 周兴长; 胡歆

    2012-01-01

    为探讨茯砖茶茶汤的稳定性,采用茯砖茶原料制作茶汤,分别在贮藏后0、7、14、21、35、42 d对茶汤中的水浸出物、多酚类、咖啡碱、氨基酸、可溶性糖、儿茶素组分含量及茶汤pH值、色泽等进行检测分析.结果表明,贮藏后0~35 d,水浸出物、多酚类、咖啡碱、氨基酸、可溶性糖、儿茶素组分含量基本稳定,上下波动幅度不明显,茶汤pH值及色泽也较稳定;贮藏后35~42 d,水浸出物、多酚类、咖啡碱、氨基酸、儿茶素组分含量急剧下降,可溶性糖含量较稳定,茶汤pH值减小,酸度增加,且色泽逐渐加深.由此可见,茯砖茶茶汤在贮藏35 d后,水浸出物、多酚类、咖啡碱、氨基酸、儿茶素组分含量减少较多,茶汤褐变严重,且产生较多沉淀.%To discuss the stability of Fu-brick tea infusion,the experiment analyzed main chemical components of Fu-brick tea beverage respectively on 0,7,14,21,35,42 days of storage, such as water extract,tea polyphenols,amino acids,caffeine,water-soluble sugar,catechin component,pH and color. The result showed that during 0 — 35 days of storage the contents of water extract,tea polyphenols,amino acids,caffeine,water-soluble sugar and catechin component were basically stable without apparent fluctuations,which fell sharply during 35 — 42 days of storage except the stable water-soluble sugar. The pH and colour remained steady during the first 35 days of storage, while tea infusion pH decreased and tea infusion color deepened gradually with more acids during 35 — 42 days. It demonstrated that after the first 35 days of storage the compositions of Fu-brick tea beverage such as water extract,tea polyphenols,amino acids,caffeine,catechin component reduced obviously,and there appeared more precipitations and a severe browning in tea color.

  18. Electromyographic analysis of the upper and lower fascicles of the orbicular oris muscle, in edentulous patients, before and after complete denture implantation.

    Science.gov (United States)

    Santos, C Moreto; Vitti, M; de Mattos, M da Glória Chiarelo; Semprini, M; Paranhos, H de Freitas Oliveira; Regalo, S Cecilio Hallak

    2003-01-01

    The orbicular oris muscle, including its upper and lower fascicles, the alveolar processes and dental arches, constitute a complex morpho-functional system, located in the lower third of the face, which is very important for the clinical determination of the occlusal vertical dimension. Any alteration of this system, as in the case of edentulous patients, might produce esthetic problems and alterations in the muscular tonicity. This study was aimed to evaluate the electromyographic behaviour of that musculature in patients while pronouncing the syllables PAH, BAH, MAH, SAH, FAH, VAH, MEE, and the word MISSISSIPPI. Edentulous patients were submitted to electromyographic tests under two clinical conditions: before and after the implantation of complete dentures. A K6-I EMG Light Channel Surface Electromyograph was utilized (Myo-tronics Co. Seattle, WA, USA). The Analysis of Variance, with 3 sources of variation (Syllables, Muscles and Clinical Conditions) and 12 repetitions, indicated statistically significant differences in the pronunciation of the different syllables. For the Muscles factor, the analysis revealed higher electromyographic readings in the lower fascicle of the orbicular oris muscle, as compared with those of the upper fascicle. The comparison among the Clinical Conditions indicated higher electromyographic values for the edentulous condition (i.e., before complete denture implantation), as compared to those recorded after denture implantation.

  19. Phase II study of neoadjuvant 5-FU + leucovorin + CPT-11 in patients with resectable liver metastases from colorectal adenocarcinoma

    Directory of Open Access Journals (Sweden)

    Bigam David

    2004-07-01

    Full Text Available Abstract Background Following resection of liver metastases from colorectal cancer, 5-year survivals are reportedly 30 – 39%. It can be assumed that this clinical situation represents systemic disease. Therefore, it is postulated that systemic chemotherapy would improve outcomes, particularly in those whose disease is sensitive to the agents administered. One potential advantage of neoadjuvant chemotherapy is that it provides in vivo chemosensitivity data. Response to neoadjuvant chemotherapy could therefore guide adjuvant chemotherapy following resection of liver metastases from colorectal cancer. Methods and design This is a prospective Phase II evaluation of outcomes in patients with potentially resectable liver metastases. Patients will receive neoadjuvant chemotherapy and will undergo resection. Postoperative chemotherapy will be directed by the degree of response to preoperative chemotherapy. All patients with Stage IV colorectal adenocarcinoma isolated to the liver that have disease that is amenable to complete ablation by resection, radiofrequency ablation, and/or cryoablation will be candidates for the trial. Patients will receive CPT-11 180 mg/m2 IV (over 90 minutes on day 1 with 5-FU 400 mg/m2 bolus and 600 mg/m2 by 22 hour infusion and calcium folinate 200 mg/m2 on days 1 and 2, every 2 weeks. Altogether, six cycles of chemotherapy will be administered. Patients will then undergo resection and/or radiofrequency ablation. Patients who had stable disease or a clinical response with preoperative chemotherapy will receive an additional 12 cycles of CPT-11 180 mg/m2 IV (over 90 minutes on day 1 with 5-FU 400 mg/m2 bolus and 600 mg/m2 by 22 hour infusion and calcium folinate 200 mg/m2 on days 1 and 2 (given every 2 weeks. Patients with resectable disease who had progressive disease during neoadjuvant chemotherapy will receive best supportive care or an alternative agent, at the discretion of the treating physician. Those patients who are

  20. 王士祯的杜甫研究%Wang Shizhen's Study of Du Fu

    Institute of Scientific and Technical Information of China (English)

    刘文刚

    2012-01-01

    Wang Shizhen's study of Du Fu was characterized most prominently by his special research thought and methods under the guideline of combining Confucian thought and his romantic charm theory. He viewed Du's poems as "Du Fu's devout eloquence" and believed that "with sincere loyalty and patriotism, they are faithful to the current events and highly regarded as historical poems", "what they are far better than others is its faithfulness to the reality", and that their artistic greatness lay in the "grand narrative recording current events faithfully with new poetic meters", "which is fu's advantage, with the function of analogy? and punning". Additionally, Wang did an extensive research on Du Fu. For example, he conducted field studies to Du's living thought and poem content, did text research on certain names and descriptions in Du's poems, on their different versions, and studied Du's influence on the great poets of the later period from the perspective of communications.%王士祯研究杜甫的最大特点,就是将儒家思想与自己的神韵理论结合起来作为研究的指导思想,形成独到的思路与方法。他对杜诗的总体评价是"杜甫圣语"。他认为杜诗"纯以忠君爱国为气骨。故形之篇章,感时纪事,则人尊诗史之称","其大过人处在诚实耳"。论杜诗的艺术的伟大是"以雄辞直写时事,以创格而纾鸿文","此正一主于赋,而兼比兴之旨者也"。王士祯对杜甫的研究非常广泛。他游宦到杜甫漂泊和生活的地方,实地考察研究杜甫的生活思想和杜诗的内容。他考释杜诗的一些名物,研究杜诗的一些版本文字,还从传播学的角度研究杜甫对后世重要诗人的影响。

  1. On the Phenomenon of Poetizing by Self-Comment in Du Fu' s Poems%论杜诗中自陈作诗的现象

    Institute of Scientific and Technical Information of China (English)

    查正贤

    2012-01-01

    In some of his poems, Du Fu liked to talk about poetizing by self-comment. This way of writing stemmed from some works in The Book of Songs, at the beginning or the end of which the authors indicated why they sang the song. This specific tradition and the learning of this way of writing gradually formed a sort of poetic art to express emotions and describe scenes, which promoted the emergence of Du Fu' s poetic creation. Du Fu' s poetic creation was a result of his devotion to exploring poetic art when he stayed alone, which made a significant influence on the history of poetry. Du Fu' s activities of poetizing by self-comment were also based on his poetic creation. Du Fu had his poems created when he was experiencing the inner-self and the outside world. As a result, Du Fu formed a unique view about poets and poems, and he definitely differed himself from other poets in the Tang Dynasty in relation to the poetic form and logical argument.%杜甫有一些在诗歌中自述“作诗”的作品,这源于对《诗经》中一些作品在首尾点出赋诗本意之法的学习,而发展成为一种特定的缘情体物的诗艺,并推动了杜诗中以诗歌创作活动为题材的现象的出现。这是杜甫在穷途独处的人生中探索诗艺的结果,不但有重要的诗歌史意义,而且也是他以诗论诗的活动产生的背景。这些论诗之作孕育于其赋诗遣怀的创作过程之中,首先也还是他的体物缘情的产物。这一性质决定了杜甫对诗歌与诗人的评论在形式和立论方式上都与唐人常见的方式有着较大的不同。

  2. 羟基喜树碱联合5Fu/CF治疗晚期大肠癌临床研究%Clinical study on HCPT combined with 5Fu/CF chemotherapy in treating patients with advanced colorectal cancer

    Institute of Scientific and Technical Information of China (English)

    段家华; 王继红; 霍丹

    2005-01-01

    目的观察应用羟基喜树碱联合5Fu/CF化疗治疗晚期大肠癌的近期疗效及不良反应.方法将24例晚期大肠癌随机分为两组.治疗组:羟基喜树碱(HCPT)8mg/m2 iv.d1~5,甲酰四氢叶酸钙200mg iv d1~5,5-氟尿嘧啶500mg/m2 iv d1~5,对照组:5F+CF用法用量同治疗组.以上方案每四周重复.结果治疗组有效率41.6%,对照组有效率33.3%,主要不良反应为消化系统,血液系统,多为Ⅰ、Ⅱ度,患者耐受好.结论HCPT联合方案治疗晚期大肠癌安全有效,值得临床进一步观察研究.

  3. On the Association of Song Yu's Fu with Fu of Han Dynasty on Their Spatial Narration——With the Analysis on the Types and Characteristics of Spatial Narration in Fu of Han Dynasty%宋玉辞赋与汉代散体大赋空间叙事的关联——兼论汉赋空间叙事的类型及其特征

    Institute of Scientific and Technical Information of China (English)

    彭安湘

    2016-01-01

    Song Yu played an important role in the transformation process of Chuci to Fu. Song Yu's works are closely related with Fu in Han dynasty on the following aspects: the extreme and growingly detailed numeration, the special idea and the three-dimensional space system embodied in the narration of Fu. The Fu writers in Han dynasty pushed the space narration to its maturity by combining the spatial ideas in ancient works and using the writing techniques of previous works. The space narration can be mainly classified into three types: position narration, class narration, and shift narration. The characteristics of space narration are as follows: the interdependence of space narration and time narration, the combination of realistic writing and fiction, the collaboration of surface structure and spatial idea.%宋玉在由楚辞到汉赋的文体转换过程中起到了重要的作用,尤其是其辞赋作品建构的立体空间坐标系,以及逐次相加的极度铺排、渲染所体现出的空间观念、"空间图式"成为与汉代散体大赋关联的新角度.汉赋作家综合古代空间意识及前代作品的创作经验进一步将空间叙事推向成熟.汉赋空间叙事主要有空间方位叙事、空间"连类"叙事和空间移位叙事三种主要类型,并具有空间叙事与时间叙事互为依存、征实与虚构互为补充以及表层结构与空间意义互为支撑等鲜明特征.

  4. YiQiFuMai Powder Injection Ameliorates Cerebral Ischemia by Inhibiting Endoplasmic Reticulum Stress-Mediated Neuronal Apoptosis

    Directory of Open Access Journals (Sweden)

    Guosheng Cao

    2016-01-01

    Full Text Available YiQiFuMai (YQFM powder injection as a modern preparation derived from Sheng Mai San, a traditional Chinese medicine, has been widely used in the treatment of cardiovascular and cerebrovascular diseases. However, its neuroprotective effect and underlying mechanism in cerebral ischemia remain to be explored. The present study was designed to investigate the neuroprotective effect of YQFM on endoplasmic reticulum (ER stress-mediated neuronal apoptosis in the permanent middle cerebral artery occlusion- (MCAO- injured mice and the oxygen-glucose deprivation- (OGD- induced pheochromocytoma (PC12 cells. The results showed that single administration of YQFM (1.342 g/kg, i.p. could reduce the brain infarction and improve the neurological deficits and the cerebral blood flow (CBF after MCAO for 24 h in mice. Moreover, incubation with YQFM (100, 200, and 400 μg/mL could increase the cell viability, decrease the caspase-3 activity, and inhibit the cell apoptosis in OGD-induced PC12 cells for 12 h. In addition, YQFM treatment could significantly modulate cleaved caspase-3 and Bcl-2 expressions and inhibit the expressions of ER stress-related marker proteins and signaling pathways in vivo and in vitro. In conclusion, our findings provide the first evidence that YQFM ameliorates cerebral ischemic injury linked with modulating ER stress-related signaling pathways, which provided some new insights for its prevention and treatment of cerebral ischemia diseases.

  5. A randomized controlled trial of Kung Fu training for metabolic health in overweight/obese adolescents: the "martial fitness" study.

    Science.gov (United States)

    Tsang, Tracey W; Kohn, Michael; Chow, Chin Moi; Singh, Maria Fiatarone

    2009-07-01

    Twenty overweight/obese adolescents underwent six months of Kung Fu or placebo (Tai Chi) training, 3x.wk(-1). Outcomes included fasting insulin and insulin resistance, lipids, glucose and HbA(1c), and C-reactive protein (CRP). CRP decreased significantly (p = 0.03) in both groups over time at six months. Although insulin sensitivity did not change, HbA(1c) tended to decrease over time (p = 0.09), again with no group difference (p = 0.60). Reduced CRP was related to increased upper body strength (p = 0.01). Increased lean body mass was related to reductions in HbA(1c), insulin resistance, triglycerides, and total cholesterol. Improvements in lean body mass appear to have a potential role in favorable metabolic outcomes, independent of changes in fat mass. Further research in this area is warranted before definite conclusions can be drawn about the efficacy of martial arts training for metabolic outcomes in this cohort.

  6. Kung Fu Training Improves Physical Fitness Measures in Overweight/Obese Adolescents: The “Martial Fitness” Study

    Science.gov (United States)

    Tsang, Tracey W.; Kohn, Michael R.; Chow, Chin Moi; Fiatarone Singh, Maria Antoinette

    2010-01-01

    Aim. To examine the efficacy of a six-month Kung Fu (KF) program on physical fitness in overweight/obese adolescents. Methods. Subjects were randomly assigned to the KF or sham exercise (Tai Chi, TC) control group. Physical measurements in cardiovascular fitness and muscle fitness occurred at baseline and after 6 months of training thrice weekly. Results. Twenty subjects were recruited. One subject was lost to follow-up, although overall compliance to the training sessions was 46.7 ± 27.8%. At follow-up, the cohort improved in absolute upper (P = .002) and lower (P = .04) body strength, and upper body muscle endurance (P = .02), without group differences. KF training resulted in significantly greater improvements in submaximal cardiovascular fitness (P = .03), lower body muscle endurance (P = .28; significant 95% CI: 0.37–2.49), and upper body muscle velocity (P = .03) relative to TC training. Conclusions. This short-term KF program improved submaximal cardiovascular fitness, lower body muscle endurance, and muscle velocity, in overweight/obese adolescents with very low baseline fitness. PMID:20798764

  7. Kung Fu Training Improves Physical Fitness Measures in Overweight/Obese Adolescents: The “Martial Fitness” Study

    Directory of Open Access Journals (Sweden)

    Tracey W. Tsang

    2010-01-01

    Full Text Available Aim. To examine the efficacy of a six-month Kung Fu (KF program on physical fitness in overweight/obese adolescents. Methods. Subjects were randomly assigned to the KF or sham exercise (Tai Chi, TC control group. Physical measurements in cardiovascular fitness and muscle fitness occurred at baseline and after 6 months of training thrice weekly. Results. Twenty subjects were recruited. One subject was lost to follow-up, although overall compliance to the training sessions was 46.7±27.8%. At follow-up, the cohort improved in absolute upper (P=.002 and lower (P=.04 body strength, and upper body muscle endurance (P=.02, without group differences. KF training resulted in significantly greater improvements in submaximal cardiovascular fitness (P=.03, lower body muscle endurance (P=.28; significant 95% CI: 0.37–2.49, and upper body muscle velocity (P=.03 relative to TC training. Conclusions. This short-term KF program improved submaximal cardiovascular fitness, lower body muscle endurance, and muscle velocity, in overweight/obese adolescents with very low baseline fitness.

  8. ELECTROMYOGRAPHIC STUDY OF A SEQUENCE OF YAU-MAN KUNG FU PALM STRIKES WITH AND WITHOUT IMPACT

    Directory of Open Access Journals (Sweden)

    Osmar Pinto Neto

    2007-10-01

    Full Text Available In martial arts and contact sports, strikes are often trained in two different ways: with and without impacts. This study aims to compare the electromyographical activity (EMG of the triceps brachii (TB, biceps brachii (BB and brachioradialis (BR muscles during strikes with and without impacts. Eight Yau-Man Kung Fu practitioners participated in the experiment. Each participant performed 5 sequences of 5 consecutive KF Yau-Man palm strikes with no impact intercalated with 5 sequences of 5 repetitions targeting a KF training shield. Surface EMG signals were obtained from the TB, BB, and RB for 3.0 seconds using an eight-channel module with a total amplifier gain of 2000 and sampled at 3500 Hz. The EMG analyses were done in the time (rms and frequency (wavelet domains. For the frequency domain, Morlet wavelet power spectra were obtained and an original method was used to quantify statistically significant regions on the power spectra. The results both in the time and frequency domains indicate a higher TB and BR muscle activity for the strikes with impacts. No significant difference was found for the BB in the two different scenarios. In addition, the results show that the wavelet power spectra pattern for the three analysed muscles obtained from the strikes with and without impacts were similar

  9. 富厚堂藏书目录浅析%Analysis of Bibliography of Fu Hou Tang

    Institute of Scientific and Technical Information of China (English)

    刘金元

    2012-01-01

    富厚堂藏书目录有很多特点,书楼第一代主人曾国藩著录的《京师书目》与《利见斋书目》信息详细;《求缺斋书目》与《公记书目》反映出其馆藏特色;《归朴斋书目》与《艺芳馆书目》则突出其藏为实用的特点。这些书目虽没有完全反映出富厚堂的馆藏,但为后人了解富厚堂馆藏及其藏书背景提供了重要参考。%Bibliography of Fu Hou Tang has many characteristics . The first master of building Tseng Kuofan recorded " Bibliography of Capital" and "Bibliography of Jian Lizhai", which are detail in information; "Bibliography of Qiu Quezhai" and " Public Bibliography" reflect abundant collections of the building; "Bibliography of Gni Puzhai" and "Bibliography of Yifang Museum" stress the characteristic of science and technology. These title catalogues become significant reference basis for the future generation to understand the background of masters collecting books and collections.

  10. Atmospheric Phase Correction using CARMA-PACS: High Angular Resolution Observations of the FU-Orionis star PP 13S*

    CERN Document Server

    Pérez, Laura M; Woody, David P; Carpenter, John M; Zauderer, B Ashley; Isella, Andrea; Bock, Douglas C; Bolatto, Alberto D; Carlstrom, John; Culverhouse, Thomas L; Joy, Marshall; Kwon, Woojin; Leitch, Erik M; Marrone, Daniel P; Muchovej, Stephen J; Plambeck, Richard L; Scott, Stephen L; Teuben, Peter J; Wright, Melvyn C H

    2010-01-01

    We present 0.15" resolution observations of the 227 GHz continuum emission from the circumstellar disk around the FU-Orionis star PP 13S*. The data were obtained with the Combined Array for Research in Millimeter-wave Astronomy (CARMA) Paired Antenna Calibration System (C-PACS), which measures and corrects the atmospheric delay fluctuations on the longest baselines of the array in order to improve the sensitivity and angular resolution of the observations. A description of the C-PACS technique and the data reduction procedures are presented. C-PACS was applied to CARMA observations of PP 13S*, which led to a factor of 1.6 increase in the observed peak flux of the source, a 36% reduction in the noise of the image, and a 52% decrease in the measured size of the source major axis. The calibrated complex visibilities were fitted with a theoretical disk model to constrain the disk surface density. The total disk mass from the best fit model corresponds to 0.06 \\msun, which is larger than the median mass of a disk ...

  11. Gauge-theoretic invariants for topological insulators: A bridge between Berry, Wess-Zumino, and Fu-Kane-Mele

    CERN Document Server

    Monaco, Domenico

    2016-01-01

    We establish a connection between two recently-proposed approaches to the understanding of the geometric origin of the Fu-Kane-Mele invariant $\\mathrm{FKM} \\in \\mathbb{Z}_2$, arising in the context of 2-dimensional time-reversal symmetric topological insulators. On the one hand, the $\\mathbb{Z}_2$ invariant can be formulated in terms of the Berry connection and the Berry curvature of the Bloch bundle of occupied states over the Brillouin torus. On the other, using techniques from the theory of bundle gerbes it is possible to provide an expression for $\\mathrm{FKM}$ containing the square root of the Wess-Zumino amplitude for a certain $U(N)$-valued field over the Brillouin torus. We link the two formulas by showing directly the equality between the above mentioned Wess-Zumino amplitude and the Berry phase, as well as between their square roots. An essential tool of independent interest is an equivariant version of the adjoint Polyakov-Wiegmann formula for fields $\\mathbb{T}^2 \\to U(N)$, of which we provide a p...

  12. Sensitivity Analysis on Fu-Liou-Gu Radiative Transfer Model for different lidar aerosol and cloud profiles

    Science.gov (United States)

    Lolli, Simone; Madonna, Fabio; Rosoldi, Marco; Pappalardo, Gelsomina; Welton, Ellsworth J.

    2016-04-01

    The aerosol and cloud impact on climate change is evaluated in terms of enhancement or reduction of the radiative energy, or heat, available in the atmosphere and at the Earth's surface, from the surface (SFC) to the Top Of the Atmosphere (TOA) covering a spectral range from the UV (extraterrestrial shortwave solar radiation) to the far-IR (outgoing terrestrial longwave radiation). Systematic Lidar network measurements from permanent observational sites across the globe are available from the beginning of this current millennium. From the retrieved lidar atmospheric extinction profiles, inputted in the Fu-Liou-Gu (FLG) Radiative Transfer code, it is possible to evaluate the net radiative effect and heating rate of the different aerosol species and clouds. Nevertheless, the lidar instruments may use different techniques (elastic lidar, Raman lidar, multi-wavelength lidar, etc) that translate into uncertainty of the lidar extinction retrieval. The goal of this study is to assess, applying a MonteCarlo technique and the FLG Radiative Transfer model, the sensitivity in calculating the net radiative effect and heating rate of aerosols and clouds for the different lidar techniques, using both synthetic and real lidar data. This sensitivity study is the first step to implement an automatic algorithm to retrieve the net radiative forcing effect of aerosols and clouds from the long records of aerosol measurements available in the frame of EARLINET and MPLNET lidar networks.

  13. I Am the Invincible Sword Goddess: Mediatization of Chinese Gender Ideology through Female Kung-Fu Practitioners in Films

    Directory of Open Access Journals (Sweden)

    Mie Hiramoto

    2014-09-01

    Full Text Available The media are avid portrayers of gender binarism and the belief in male-female distinctions, which are mainly attributed to perceived differences of a physical nature. In this paper, we investigate representations of female kung-fu practitioners (nuxia in films to discuss how processes of mediation and mediatization depict their femininity, so as to mitigate their appropriation of Chinese martial arts masculinity. Often, nuxias are portrayed as empowered women who are equipped to take control of their own lives and to courageously take on challenges from a variety of opponents. However, multimodal deconstruction of the various characteristics of nuxias must be placed in an Asian-specific context in order to understand the femininity specific to these characters and to move beyond Western gender ideologies displayed by the media. Perpetuating Confucian patriarchal ideals, nuxia roles constantly and consistently associate conformation to Confucian values with virtuousness and non-conformation with wickedness. We therefore can use the ideals of Confucianism as a more accurate foundation in deconstructing the identities of nuxias, which allows us to better understand the mediation and mediatization processes of ideologies associated with Chinese femininity and masculinity in martial arts films.

  14. «A Ca’ Giustinian fu tutto diverso». La mostra di Paolo Veronese a Venezia (1939

    Directory of Open Access Journals (Sweden)

    Matilde Cartolari

    2016-12-01

    Full Text Available La mostra di Paolo Veronese si svolse a Venezia nel 1939 sotto la direzione di Rodolfo Pallucchini. Promuovendo una ricognizione materiale e critica dell’opera del maestro, la mostra fu l’occasione per effettuare una massiccia campagna di restauri ad opera del bergamasco Mauro Pellicioli e della sua squadra di collaboratori. Agendo sul duplice fronte della museografia e del restauro, Pallucchini si pose in dialogo con le parallele definizioni elaborate in sede istituzionale da Guglielmo Pacchioni e Giulio Carlo Argan. Il presente saggio intende offrire, attraverso materiale archivistico inedito, un’analisi del ruolo della mostra di Veronese nel contesto nazionale e internazionale, ricostruendo con un approccio interdisciplinare le dinamiche teoriche e operative che ne animarono lo svolgimento. Veronese exhibition took place in Venice in 1939 under the direction of Rodolfo Pallucchini. While promoting both material and critical examination of Veronese’s work, the exhibition was an opportunity to undertake a massive restoration, performed by Mauro Pellicioli and his team of collaborators. Pallucchini’s museographical and conservative program was in close relation with the theories promoted by Guglielmo Pacchioni and Giulio Carlo Argan in public administration. This paper intends to offer, through unpublished archival evidence, a detailed analysis of Veronese exhibition in relation to national and international context, in order to understand with an interdisciplinary approach both its theoretical and practical aspects.

  15. VARIABILITY AT THE EDGE: OPTICAL NEAR/IR RAPID-CADENCE MONITORING OF NEWLY OUTBURSTING FU ORIONIS OBJECT HBC 722

    Energy Technology Data Exchange (ETDEWEB)

    Green, Joel D.; Robertson, Paul; Pak, Soojong; Meschiari, Stefano [Department of Astronomy, 2515 Speedway, University of Texas at Austin, Austin, TX (United States); Baek, Giseon; Lee, Jeong-Eun [School of Space Research, Kyung Hee University, Gyeonggi-Do 446-741 (Korea, Republic of); Pooley, David [Department of Physics, Sam Houston State University, Huntsville, TX (United States); Im, Myungshin; Jeon, Yiseul; Choi, Changsu [CEOU/Department of Physics and Astronomy, Seoul National University, Seoul 151-742 (Korea, Republic of)

    2013-02-10

    We present the detection of day-timescale periodic variability in the r-band lightcurve of newly outbursting FU Orionis-type object HBC 722, taken from >42 nights of observation with the CQUEAN instrument on the McDonald Observatory 2.1 m telescope. The optical/near-IR lightcurve of HBC 722 shows a complex array of periodic variability, clustering around 5.8-day (0.044 mag amplitude) and 1.28-day (0.016 mag amplitude) periods, after removal of overall baseline variation. We attribute the unusual number of comparable strength signals to a phenomenon related to the temporary increase in accretion rate associated with FUors. We consider semi-random 'flickering', magnetic braking/field compression and rotational asymmetries in the disk instability region as potential sources of variability. Assuming that the 5.8-day period is due to stellar rotation and the 1.28-day period is indicative of Keplerian rotation at the inner radius of the accretion disk (at 2 R {sub *}), we derive a B-field strength of 2.2-2.7 kG, slightly larger than typical T Tauri stars. If instead the 5.8-day signal is from a disk asymmetry, the instability region has an outer radius of 5.4 R {sub *}, consistent with models of FUor disks. Further exploration of the time domain in this complicated source and related objects will be key to understanding accretion processes.

  16. Variability at the Edge: Optical Near/IR Rapid Cadence Monitoring of Newly Outbursting FU Orionis Object HBC 722

    CERN Document Server

    Green, Joel D; Baek, Giseon; Pooley, David; Pak, Soojong; Im, Myungshin; Lee, Jeong-Eun; Jeon, Yiseul; Choi, Changsu; Meschiari, Stefano

    2012-01-01

    We present the detection of day-timescale periodic variability in the r-band lightcurve of newly outbursting FU Orionis-type object HBC 722, taken from > 42 nights of observation with the CQUEAN instrument on the McDonald Observatory 2.1m telescope. The optical/near-IR lightcurve of HBC 722 shows a complex array of periodic variability, clustering around 5.8 day (0.044 mag amplitude) and 1.28 day (0.016 mag amplitude) periods, after removal of overall baseline variation. We attribute the unusual number of comparable strength signals to a phenomenon related to the temporary increase in accretion rate associated with FUors. We consider semi-random "flickering", magnetic braking/field compression and rotational asymmetries in the disk instability region as potential sources of variability. Assuming the 5.8 day period is due to stellar rotation and the 1.28 day period is indicative of Keplerian rotation at the inner radius of the accretion disk (at 2 R(star)), we derive a B-field strength of 2.2-2.7 kG, slightly ...

  17. Technical note: Fu-Liou-Gu and Corti-Peter model performance evaluation for radiative retrievals from cirrus clouds

    Science.gov (United States)

    Lolli, Simone; Campbell, James R.; Lewis, Jasper R.; Gu, Yu; Welton, Ellsworth J.

    2017-06-01

    We compare, for the first time, the performance of a simplified atmospheric radiative transfer algorithm package, the Corti-Peter (CP) model, versus the more complex Fu-Liou-Gu (FLG) model, for resolving top-of-the-atmosphere radiative forcing characteristics from single-layer cirrus clouds obtained from the NASA Micro-Pulse Lidar Network database in 2010 and 2011 at Singapore and in Greenbelt, Maryland, USA, in 2012. Specifically, CP simplifies calculation of both clear-sky longwave and shortwave radiation through regression analysis applied to radiative calculations, which contributes significantly to differences between the two. The results of the intercomparison show that differences in annual net top-of-the-atmosphere (TOA) cloud radiative forcing can reach 65 %. This is particularly true when land surface temperatures are warmer than 288 K, where the CP regression analysis becomes less accurate. CP proves useful for first-order estimates of TOA cirrus cloud forcing, but may not be suitable for quantitative accuracy, including the absolute sign of cirrus cloud daytime TOA forcing that can readily oscillate around zero globally.

  18. Protective effect of the extract of Yi-Qi-Fu-Mai preparation on hypoxia-induced heart injury in mice

    Institute of Scientific and Technical Information of China (English)

    FENG Ya-Qian; JU Ai-Chun; LIU Chun-Hua; WANG Ting; YU Bo-Yang; QI Jin

    2016-01-01

    Yi-Qi-Fu-Mai (YQFM) is extensively used clinically to treat cardiovascular diseases in China.To explore the anti-hypoxia effect of the extract of YQFM preparation (EYQFM),the EYQFM (1.4,2.8,and 5.5 g·kg-1·d-1) was assessed for its heart-protective effect in a chronic intermittent hypoxia (CIH) animal model (oxygen pressure 7%-8%,20 min per day) for 28 days of treatment.Betaloc (0.151 6 g·kg-1·d-1) was used as a positive control.The histopathological analyses of heart in CIH mice were conducted.Several cardiac state parameters,such as left ventricular ejection fractions (EF),stroke volume (SV),expression of creatine kinase (CK),lactate dehydrogenase (LDH),superoxide dismutase (SOD),and malondialdehyde (MDA) were measured.The results showed that treatment with EYQFM markedly reversed swelling of the endothelial cells and vacuolization in the heart when compared with the model group.Further study demonstrated that EYQFM significantly improved ventricular myocardial contractility by increasing EF and SV.In addition,EYQFM inhibited the activity of CK,LDH,decreased the level of MDA and improved SOD activity.The results demonstrated that EYQFM significantly improved the tolerability of myocardium to hypoxia and ameliorated the cardiac damage in the CIH model.

  19. Introduction to Baoz hao’ s Emotions in His Fu%浅谈鲍照赋的思想情感

    Institute of Scientific and Technical Information of China (English)

    陈刚

    2014-01-01

    Because of Bao Zhao’s special life experience and his inheritance of Fu in Wei and Jin Dynasties ,the theme of his Fu’s is basical-ly around releasing the pathos ,which contains both the bleak and anxious emotions with ambitious but unachievable aims ,as well as the subli-mated ,gorgeous and affecting writing style ,showing a high degree of combination of rhetoric and emotion then demonstrating a unique look in the transition of Fu’s creation from Wei and Jin Dynasties to the Southern Dynasties .%由于鲍照特殊的身世经历和他对魏晋赋的继承接受,鲍照赋的思想情感基本围绕宣泄悲情而展开,既包含苍壮急怨、清拔阔大的情感特质,又显得奇崛伟丽、藻艳精工、倾炫心魄,表现出辞、情的高度统一,在辞赋创作由魏晋向南朝的过渡中呈现了一种独特的面貌。

  20. Gauge-theoretic invariants for topological insulators: a bridge between Berry, Wess-Zumino, and Fu-Kane-Mele

    Science.gov (United States)

    Monaco, Domenico; Tauber, Clément

    2017-02-01

    We establish a connection between two recently proposed approaches to the understanding of the geometric origin of the Fu-Kane-Mele invariant FKMin Z_2 , arising in the context of two-dimensional time-reversal symmetric topological insulators. On the one hand, the Z_2 invariant can be formulated in terms of the Berry connection and the Berry curvature of the Bloch bundle of occupied states over the Brillouin torus. On the other, using techniques from the theory of bundle gerbes, it is possible to provide an expression for FKM containing the square root of the Wess-Zumino amplitude for a certain U(N)-valued field over the Brillouin torus. We link the two formulas by showing directly the equality between the above-mentioned Wess-Zumino amplitude and the Berry phase, as well as between their square roots. An essential tool of independent interest is an equivariant version of the adjoint Polyakov-Wiegmann formula for fields T^2 → U(N) , of which we provide a proof employing only basic homotopy theory and circumventing the language of bundle gerbes.