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Sample records for pre-initiation complex pic

  1. Genome-wide uniformity of human ‘open’ pre-initiation complexes

    Science.gov (United States)

    Lai, William K.M.; Pugh, B. Franklin

    2017-01-01

    Transcription of protein-coding and noncoding DNA occurs pervasively throughout the mammalian genome. Their sites of initiation are generally inferred from transcript 5′ ends and are thought to be either locally dispersed or focused. How these two modes of initiation relate is unclear. Here, we apply permanganate treatment and chromatin immunoprecipitation (PIP-seq) of initiation factors to identify the precise location of melted DNA separately associated with the preinitiation complex (PIC) and the adjacent paused complex (PC). This approach revealed the two known modes of transcription initiation. However, in contrast to prevailing views, they co-occurred within the same promoter region: initiation originating from a focused PIC, and broad nucleosome-linked initiation. PIP-seq allowed transcriptional orientation of Pol II to be determined, which may be useful near promoters where sufficient sense/anti-sense transcript mapping information is lacking. PIP-seq detected divergently oriented Pol II at both coding and noncoding promoters, as well as at enhancers. Their occupancy levels were not necessarily coupled in the two orientations. DNA sequence and shape analysis of initiation complex sites suggest that both sequence and shape contribute to specificity, but in a context-restricted manner. That is, initiation sites have the locally “best” initiator (INR) sequence and/or shape. These findings reveal a common core to pervasive Pol II initiation throughout the human genome. PMID:27927716

  2. Polyion complex (PIC) particles: Preparation and biomedical applications.

    Science.gov (United States)

    Insua, Ignacio; Wilkinson, Andrew; Fernandez-Trillo, Francisco

    2016-08-01

    Oppositely charged polyions can self-assemble in solution to form colloidal polyion complex (PIC) particles. Such nanomaterials can be loaded with charged therapeutics such as DNA, drugs or probes for application as novel nanomedicines and chemical sensors to detect disease markers. A comprehensive discussion of the factors affecting PIC particle self-assembly and their response to physical and chemical stimuli in solution is described herein. Finally, a collection of key examples of polyionic nanoparticles for biomedical applications is discussed to illustrate their behaviour and demonstrate the potential of PIC nanoparticles in medicine.

  3. Herpesvirus late gene expression: a viral-specific Pre-Initiation Complex is key

    Directory of Open Access Journals (Sweden)

    Henri eGruffat

    2016-06-01

    Full Text Available During their productive cycle, herpesviruses exhibit a strictly regulated temporal cascade of gene expression that can be divided into three general stages: immediate-early (IE, early (E and late (L. This expression program is the result of a complex interplay between viral and cellular factors at both the transcriptional and post-transcriptional levels, as well as structural differences within the promoter architecture for each of the three gene classes. Since the cellular enzyme RNA polymerase II (RNAP-II is responsible for the transcription of herpesvirus genes, most viral promoters contain DNA motifs that are common with those of cellular genes, although promoter complexity decreases from immediate-early to late genes. Immediate-early and early promoters contain numerous cellular and viral cis-regulating sequences upstream of a TATA box, whereas late promoters differ significantly in that they lack cis-acting sequences upstream of the Transcription Start Site (TSS. Moreover, in the case of the β- and γ-herpesviruses, a TATT box motif is frequently found in the position where the consensus TATA box of eukaryotic promoters usually localizes. The mechanisms of transcriptional regulation of the late viral gene promoters appear to be different between α-herpesviruses and the two other herpesvirus subfamilies ( and . In this review, we will compare the mechanisms of late gene transcriptional regulation between HSV-1, for which the viral IE transcription factors - especially ICP4 - play an essential role, and the two other subfamilies of herpesviruses, with a particular emphasis on EBV, which has recently been found to code for its own specific TATT-binding protein.

  4. The Epstein-Barr Virus Immunoevasins BCRF1 and BPLF1 Are Expressed by a Mechanism Independent of the Canonical Late Pre-initiation Complex

    Science.gov (United States)

    McKenzie, Jessica; Delecluse, Henri-Jacques; El-Guindy, Ayman

    2016-01-01

    Subversion of host immune surveillance is a crucial step in viral pathogenesis. Epstein-Barr virus (EBV) encodes two immune evasion gene products, BCRF1 (viral IL-10) and BPLF1 (deubiquitinase/deneddylase); both proteins suppress antiviral immune responses during primary infection. The BCRF1 and BPLF1 genes are expressed during the late phase of the lytic cycle, an essential but poorly understood phase of viral gene expression. Several late gene regulators recently identified in beta and gamma herpesviruses form a viral pre-initiation complex for transcription. Whether each of these late gene regulators is necessary for transcription of all late genes is not known. Here, studying viral gene expression in the absence and presence of siRNAs to individual components of the viral pre-initiation complex, we identified two distinct groups of late genes. One group includes late genes encoding the two immunoevasins, BCRF1 and BPLF1, and is transcribed independently of the viral pre-initiation complex. The second group primarily encodes viral structural proteins and is dependent on the viral pre-initiation complex. The protein kinase BGLF4 is the only known late gene regulator necessary for expression of both groups of late genes. ChIP-seq analysis showed that the transcription activator Rta associates with the promoters of eight late genes including genes encoding the viral immunoevasins. Our results demonstrate that late genes encoding immunomodulatory proteins are transcribed by a mechanism distinct from late genes encoding viral structural proteins. Understanding the mechanisms that specifically regulate expression of the late immunomodulatory proteins could aid the development of antiviral drugs that impair immune evasion by the oncogenic EB virus. PMID:27855219

  5. Enzyme-responsive polyion complex (PIC) nanoparticles for the targeted delivery of antimicrobial polymers.

    Science.gov (United States)

    Insua, Ignacio; Liamas, Evangelos; Zhang, Zhenyu; Peacock, Anna F A; Krachler, Anne Marie; Fernandez-Trillo, Francisco

    2016-04-21

    Here we present new enzyme-responsive polyion complex (PIC) nanoparticles prepared from antimicrobial poly(ethylene imine) and an anionic enzyme-responsive peptide targeting Pseudomonas aeruginosa's elastase. The synthetic conditions used to prepare these nanomaterials allowed us to optimise particle size and charge, and their stability under physiological conditions. We demonstrate that these enzyme responsive PIC nanoparticles are selectively degraded in the presence of P. aeruginosa elastase without being affected by other endogenous elastases. This enzyme-responsive PIC particle can exert an elastase-specific antimicrobial effect against P. aeruginosa without affecting non-pathogenic strains of these bacteria. These targeted enzyme-responsive PIC nanoparticles constitute a novel platform for the delivery of antimicrobial peptides and polymers, and can be a powerful tool in the current race against antimicrobial resistance.

  6. Preparation and antimicrobial evaluation of polyion complex (PIC) nanoparticles loaded with polymyxin B.

    Science.gov (United States)

    Insua, Ignacio; Majok, Sieta; Peacock, Anna F A; Krachler, Anne Marie; Fernandez-Trillo, Francisco

    2017-02-01

    Here, we describe novel polyion complex (PIC) particles for the delivery of Polymyxin B (Pol-B), an antimicrobial peptide currently used in the clinic as a last resort antibiotic against multidrug-resistant gram-negative bacteria. A range of conditions for the controlled assembly of Pol-B with poly(styrene sulphonate) (PSS) has been identified which let us prepare stable colloidal PIC particles. This way, PIC particles containing different Pol-B:PSS ratios have been prepared and their stability under simulated physiological conditions (i.e. pH, osmotic pressure and temperature) characterised. Furthermore, preliminary evaluation of the antimicrobial activity of these Pol-B containing PIC particles has been performed, by monitoring their effect on the growth of Pseudomonas aeruginosa, an opportunistic gram-negative bacterium.

  7. Mutations in CDC45, Encoding an Essential Component of the Pre-initiation Complex, Cause Meier-Gorlin Syndrome and Craniosynostosis.

    Science.gov (United States)

    Fenwick, Aimee L; Kliszczak, Maciej; Cooper, Fay; Murray, Jennie; Sanchez-Pulido, Luis; Twigg, Stephen R F; Goriely, Anne; McGowan, Simon J; Miller, Kerry A; Taylor, Indira B; Logan, Clare; Bozdogan, Sevcan; Danda, Sumita; Dixon, Joanne; Elsayed, Solaf M; Elsobky, Ezzat; Gardham, Alice; Hoffer, Mariette J V; Koopmans, Marije; McDonald-McGinn, Donna M; Santen, Gijs W E; Savarirayan, Ravi; de Silva, Deepthi; Vanakker, Olivier; Wall, Steven A; Wilson, Louise C; Yuregir, Ozge Ozalp; Zackai, Elaine H; Ponting, Chris P; Jackson, Andrew P; Wilkie, Andrew O M; Niedzwiedz, Wojciech; Bicknell, Louise S

    2016-07-07

    DNA replication precisely duplicates the genome to ensure stable inheritance of genetic information. Impaired licensing of origins of replication during the G1 phase of the cell cycle has been implicated in Meier-Gorlin syndrome (MGS), a disorder defined by the triad of short stature, microtia, and a/hypoplastic patellae. Biallelic partial loss-of-function mutations in multiple components of the pre-replication complex (preRC; ORC1, ORC4, ORC6, CDT1, or CDC6) as well as de novo stabilizing mutations in the licensing inhibitor, GMNN, cause MGS. Here we report the identification of mutations in CDC45 in 15 affected individuals from 12 families with MGS and/or craniosynostosis. CDC45 encodes a component of both the pre-initiation (preIC) and CMG helicase complexes, required for initiation of DNA replication origin firing and ongoing DNA synthesis during S-phase itself, respectively, and hence is functionally distinct from previously identified MGS-associated genes. The phenotypes of affected individuals range from syndromic coronal craniosynostosis to severe growth restriction, fulfilling diagnostic criteria for Meier-Gorlin syndrome. All mutations identified were biallelic and included synonymous mutations altering splicing of physiological CDC45 transcripts, as well as amino acid substitutions expected to result in partial loss of function. Functionally, mutations reduce levels of full-length transcripts and protein in subject cells, consistent with partial loss of CDC45 function and a predicted limited rate of DNA replication and cell proliferation. Our findings therefore implicate the preIC as an additional protein complex involved in the etiology of MGS and connect the core cellular machinery of genome replication with growth, chondrogenesis, and cranial suture homeostasis.

  8. A Highly Reactive Seven-Coordinate Osmium(V) Oxo Complex: [Os(V)(O)(qpy)(pic)Cl](2+).

    Science.gov (United States)

    Liu, Yingying; Ng, Siu-Mui; Lam, William W Y; Yiu, Shek-Man; Lau, Tai-Chu

    2016-01-04

    Seven-coordinate ruthenium oxo species have been proposed as active intermediates in catalytic water oxidation by a number of highly active ruthenium catalysts, however such species have yet to be isolated. Reported herein is the first example of a seven-coordinate group 8 metal-oxo species, [Os(V)(O)(qpy)(pic)Cl](2+) (qpy = 2,2':6',2'':6'',2'''-quaterpyridine, pic = 4-picoline). The X-ray crystal structure of this complex shows that it has a distorted pentagonal bipyramidal geometry with an Os=O distance of 1.7375 Å. This oxo species undergoes facile O-atom and H-atom-transfer reactions with various organic substrates. Notably it can abstract H atoms from alkylaromatics with C-H bond dissociation energy as high as 90 kcal mol(-1). This work suggests that highly active oxidants may be designed based on group 8 seven-coordinate metal oxo species.

  9. pH-Regulated Reversible Transition Between Polyion Complexes (PIC) and Hydrogen-Bonding Complexes (HBC) with Tunable Aggregation-Induced Emission.

    Science.gov (United States)

    Tian, Sidan; Liu, Guhuan; Wang, Xiaorui; Wu, Tao; Yang, Jinxian; Ye, Xiaodong; Zhang, Guoying; Hu, Jinming; Liu, Shiyong

    2016-02-17

    The mimicking of biological supramolecular interactions and their mutual transitions to fabricate intelligent artificial systems has been of increasing interest. Herein, we report the fabrication of supramolecular micellar nanoparticles consisting of quaternized poly(ethylene oxide)-b-poly(2-dimethylaminoethyl methacrylate) (PEO-b-PQDMA) and tetrakis(4-carboxylmethoxyphenyl)ethene (TPE-4COOH), which was capable of reversible transition between polyion complexes (PIC) and hydrogen bonding complexes (HBC) with tunable aggregation-induced emission (AIE) mediated by solution pH. At pH 8, TPE-4COOH chromophores can be directly dissolved in aqueous milieu without evident fluorescence emission. However, upon mixing with PEO-b-PQDMA, polyion complexes were formed by taking advantage of electrostatic interaction between carboxylate anions and quaternary ammonium cations and the most compact PIC micelles were achieved at the isoelectric point (i.e., [QDMA(+)]/[COO(-)] = 1), as confirmed by dynamic light scattering (DLS) measurement. Simultaneously, fluorescence spectroscopy revealed an evident emission turn-on and the maximum fluorescence intensity was observed near the isoelectric point due to the restriction of intramolecular rotation of TPE moieties within the PIC cores. The kinetic study supported a micelle fusion/fission mechanism on the formation of PIC micelles at varying charge ratios, exhibiting a quick time constant (τ1) relating to the formation of quasi-equilibrium micelles and a slow time constant (τ2) corresponding to the formation of final equilibrium micelles. Upon deceasing the pH of PIC micelles from 8 to 2 at the [QDMA(+)]/[COO(-)] molar ratio of 1, TPE-4COOH chromophores became gradually protonated and hydrophobic. The size of micellar nanoparticles underwent a remarkable decrease, whereas the fluorescence intensity exhibited a further increase by approximately 7.35-fold, presumably because of the formation of HBC micelles comprising cationic PQDMA

  10. Physicochemical properties of pH-controlled polyion complex (PIC) micelles of poly(acrylic acid)-based double hydrophilic block copolymers and various polyamines.

    Science.gov (United States)

    Warnant, J; Marcotte, N; Reboul, J; Layrac, G; Aqil, A; Jerôme, C; Lerner, D A; Gérardin, C

    2012-05-01

    The physicochemical properties of polyion complex (PIC) micelles were investigated in order to characterize the cores constituted of electrostatic complexes of two oppositely charged polyelectrolytes. The pH-sensitive micelles were obtained with double hydrophilic block copolymers containing a poly(acrylic acid) block linked to a modified poly(ethylene oxide) block and various polyamines (polylysine, linear and branched polyethyleneimine, polyvinylpyridine, and polyallylamine). The pH range of micellization in which both components are ionized was determined for each polyamine. The resulting PIC micelles were characterized using dynamic light scattering and small-angle X-ray scattering experiments (SAXS). The PIC micelles presented a core-corona nanostructure with variable polymer density contrasts between the core and the corona, as revealed by the analysis of the SAXS curves. It was shown that PIC micelle cores constituted by polyacrylate chains and polyamines were more or less dense depending on the nature of the polyamine. It was also determined that the density of the cores of the PIC micelles depended strongly on the nature of the polyamine. These homogeneous cores were surrounded by a large hairy corona of hydrated polyethylene oxide block chains. Auramine O (AO) was successfully entrapped in the PIC micelles, and its fluorescence properties were used to get more insight on the core properties. Fluorescence data confirmed that the cores of such micelles are quite compact and that their microviscosity depended on the nature of the polyamine. The results obtained on these core-shell micelles allow contemplating a wide range of applications in which the AO probe would be replaced by various cationic drugs or other similarly charged species to form drug nanocarriers or new functional nanodevices.

  11. Formation of Polyion Complex (PIC) Micelles and Vesicles with Anionic pH-Responsive Unimer Micelles and Cationic Diblock Copolymers in Water.

    Science.gov (United States)

    Ohno, Sayaka; Ishihara, Kazuhiko; Yusa, Shin-Ichi

    2016-04-26

    A random copolymer (p(A/MaU)) of sodium 2-(acrylamido)-2-methylpropanesulfonate (AMPS) and sodium 11-methacrylamidoundecanate (MaU) was prepared via conventional radical polymerization, which formed a unimer micelle under acidic conditions due to intramolecular hydrophobic interactions between the pendant undecanoic acid groups. Under basic conditions, unimer micelles were opened up to an expanded chain conformation by electrostatic repulsion between the pendant sulfonate and undecanoate anions. A cationic diblock copolymer (P163M99) consisting of poly(3-(methacrylamido)propyl)trimethylammonium chloride (PMAPTAC) and hydrophilic polybetaine, 2-(methacryloyloxy)ethylphosphorylcholine (MPC), blocks was prepared via controlled radical polymerization. Mixing of p(A/MaU) and P163M99 in 0.1 M aqueous NaCl under acidic conditions resulted in the formation of spherical polyion complex (PIC) micelles and vesicles, depending on polymer concentration before mixing. Shapes of the PIC micelles and vesicles changed under basic conditions due to collapse of the charge balance between p(A/MaU) and P163M99. The PIC vesicles can incorporate nonionic hydrophilic guest molecules, and the PIC micelles and vesicles can accept hydrophobic guest molecules in the hydrophobic core formed from p(A/MaU).

  12. PIC: Protein Interactions Calculator.

    Science.gov (United States)

    Tina, K G; Bhadra, R; Srinivasan, N

    2007-07-01

    Interactions within a protein structure and interactions between proteins in an assembly are essential considerations in understanding molecular basis of stability and functions of proteins and their complexes. There are several weak and strong interactions that render stability to a protein structure or an assembly. Protein Interactions Calculator (PIC) is a server which, given the coordinate set of 3D structure of a protein or an assembly, computes various interactions such as disulphide bonds, interactions between hydrophobic residues, ionic interactions, hydrogen bonds, aromatic-aromatic interactions, aromatic-sulphur interactions and cation-pi interactions within a protein or between proteins in a complex. Interactions are calculated on the basis of standard, published criteria. The identified interactions between residues can be visualized using a RasMol and Jmol interface. The advantage with PIC server is the easy availability of inter-residue interaction calculations in a single site. It also determines the accessible surface area and residue-depth, which is the distance of a residue from the surface of the protein. User can also recognize specific kind of interactions, such as apolar-apolar residue interactions or ionic interactions, that are formed between buried or exposed residues or near the surface or deep inside.

  13. Programando microcontroladores PIC en lenguaje C

    OpenAIRE

    Henao, Carlos Alberto; Duque Cardona, Edison

    2009-01-01

    En este artículo se presenta el manejo del compilador PCW para microcontroladores PIC, el cual permite programar fácilmente los microcontroladores en lenguaje C, con lo cual se realiza más rápidamente el desarrollo de programas que serían bastante complejos de abordar en lenguaje ensamblador. In this article management PCW compiler for PIC microcontrollers, which can easily program the PIC microcontrollers in C language, which is quickly developing programs that would be quite complex ...

  14. Compare Research of PIC/S, PIC/S GMP and Chinese GMP%PIC/S、PIC/S GMP与中国GMP的比较研究

    Institute of Scientific and Technical Information of China (English)

    张卓光

    2010-01-01

    目的 介绍药品监管公约/药品监管合作计划(PIC/S)和PIC/S GMP,比较PIC/S GMP 和中国GMP(98修订)的差异. 方法 从历史变革、机构与运行机制、宗旨以及PIC/S GMP的影响来阐述PIC/S;从人员、硬件、软件等方面来比较PIC/S GMP 与中国GMP.结果 PIC/S在药品领域倡导GMP标准、检查一致以及互认,促进了GMP发展.结论 PIC/S GMP是国际上高水平的GMP.

  15. Solid state synthesis, spectroscopic and X-ray studies of metal complexes of 2-picolinic acid and vapochromic behavior of [Co(Pic)2(H2O)2]·2H2O

    Science.gov (United States)

    Tella, Adedibu C.; Oladipo, Adetola C.; Adeyemi, Olalere G.; Oluwafemi, Oluwatobi S.; Oguntoye, Stephen O.; Alimi, Lukman O.; Ajayi, Joseph T.; Degni, Sylvestre K.

    2017-06-01

    Three compounds, [Cu(Pic)2(H2O)] (1a), [M(Pic)2(H2O)2]·2H2O] (M=Co (2a), Zn (3a), Pic = 2-picolinic acid) were obtained by solvent-free synthesis through grinding of metal acetate salt with 2-picolinic acid. Favorable comparison of solvent-free with solution based method of 1b, 2b and 3b was observed. Good resemblance of identity of compounds obtained through the two methods was confirmed by elemental analysis, spectroscopic techniques (UV-Vis and FTIR), TGA and PXRD. The single crystal diffraction data for [Co(Pic)2(H2O)2]·2H2O obtained from the Cambridge structure database (CSD), its PXRD simulated patterns closely matched that of complex 2a by solvent-free synthesis. Vapochromic behavior of this complex was studied using colour change, FT-IR, TGA, PXRD and solid state UV-visible spectroscopies. This complex generated specific colour which is also evident in the shifting of the vibrational frequencies (νO-H and ν C=O bands). The resulting inclusion compounds have different colours depending on the solvent used. In addition, exposure of the resultant inclusion compounds to ambient environment or heating for a few minutes regenerate the original material without degradation even after exposure/heating cycles as evident from TGA/DTG thermograms.

  16. Synthesis and Characterization of a Ditriflate-Bridged, Diiron(II) Complex with Syn-N-Donor Ligands: [Fe(2)(μ-OTf)(2)(PIC(2)DET)(2)](BARF)(2).

    Science.gov (United States)

    Kodanko, Jeremy J; Lippard, Stephen J

    2008-03-03

    The synthesis and characterization of the diiron(II) complex [Fe(2)(μ-OTf)(2)-(PIC(2)DET)(2)](BARF)(2) (2), where PIC(2)DET is a 2,3-diethynyltriptycene-linked dipicolinic methyl ester ligand, are described. The dication in 2, contains, [Fe(2)(μ-OTf)(2)(PIC(2)DET)(2)](2+) two symmetry-equivalent iron atoms with octahedral coordination geometries. Each metal ion has a N(2)O(4) atom donor set that includes four atoms from two picolinic ester N,O chelate rings, as well as two oxygen atoms from the bridging trifluoromethanesulfonate groups. The Fe(2)(μ-OTf)(2) core of 2 is stabilized by two PIC(2)DET ligands that bind the two metal ions in a head-to-head fashion, leading to an Fe···Fe distance of 5.173(1)Å. Molar conductivity data for 2 are consistent with Fe(2)(μ-OTf)(2)(PIC(2)DET)(2)](2+) retaining its identity in acetone solutions, where it behaves as a 2:1 electrolyte. (1)H NMR spectroscopic, solution (d(6)-acetone) and solid-state magnetic susceptibility data all indicate that the iron atoms of 2 are high-spin (S = 2). A fit of the magnetic data (2 - 300K) to a spin-only isotropic exchange Hamiltonian H = -2JS(1)·S(2) are consistent with weak antiferromagnetic coupling between the two iron atoms with J ~ -0.99(2) cm(-1) and g = 2.10(1).

  17. What Makes a PIC Tick?

    Science.gov (United States)

    Montgomery, H. Wynn

    1988-01-01

    The author discusses the establishment and objectives of private industry councils (PICs). Such topics as local decision making, private sector representation, on-site evaluations, and summer jobs programs are covered. Emphasis is on the Atlanta, Georgia PIC. (CH)

  18. PIC Activation through Functional Interplay between Mediator and TFIIH.

    Science.gov (United States)

    Malik, Sohail; Molina, Henrik; Xue, Zhu

    2017-01-06

    The multiprotein Mediator coactivator complex functions in large part by controlling the formation and function of the promoter-bound preinitiation complex (PIC), which consists of RNA polymerase II and general transcription factors. However, precisely how Mediator impacts the PIC, especially post-recruitment, has remained unclear. Here, we have studied Mediator effects on basal transcription in an in vitro transcription system reconstituted from purified components. Our results reveal a close functional interplay between Mediator and TFIIH in the early stages of PIC development. We find that under conditions when TFIIH is not normally required for transcription, Mediator actually represses transcription. TFIIH, whose recruitment to the PIC is known to be facilitated by the Mediator, then acts to relieve Mediator-induced repression to generate an active form of the PIC. Gel mobility shift analyses of PICs and characterization of TFIIH preparations carrying mutant XPB translocase subunit further indicate that this relief of repression is achieved through expending energy via ATP hydrolysis, suggesting that it is coupled to TFIIH's established promoter melting activity. Our interpretation of these results is that Mediator functions as an assembly factor that facilitates PIC maturation through its various stages. Whereas the overall effect of the Mediator is to stimulate basal transcription, its initial engagement with the PIC generates a transcriptionally inert PIC intermediate, which necessitates energy expenditure to complete the process.

  19. [PIC Program Evaluation Forms.

    Science.gov (United States)

    Short, N. J.

    These 4 questionnaires are designed to elicit teacher and parent evaluations of the Prescriptive Instruction Center (PIC) program. Included are Teacher Evaluation of Program Effectiveness (14 items), M & M Evaluation of Program Implementation (methods and materials specialists; 11 items), Teacher Evaluation of Program Effectiveness--Case Study…

  20. PIC Reading Readiness Test Form.

    Science.gov (United States)

    Short, N. J.

    This rating form concerns the measurement of basic skills in connection with assessing reading readiness. Motor skills, ability to adjust to learning situations, familiarity with the alphabet, and general knowledge are assessed. See TM 001 111 for details of the Regional PIC program in which it is used. (DLG)

  1. SD card projects using the PIC microcontroller

    CERN Document Server

    Ibrahim, Dogan

    2010-01-01

    PIC Microcontrollers are a favorite in industry and with hobbyists. These microcontrollers are versatile, simple, and low cost making them perfect for many different applications. The 8-bit PIC is widely used in consumer electronic goods, office automation, and personal projects. Author, Dogan Ibrahim, author of several PIC books has now written a book using the PIC18 family of microcontrollers to create projects with SD cards. This book is ideal for those practicing engineers, advanced students, and PIC enthusiasts that want to incorporate SD Cards into their devices. SD cards are che

  2. PIC Detector for Piano Chords

    Science.gov (United States)

    Barbancho, Ana M.; Tardón, Lorenzo J.; Barbancho, Isabel

    2010-12-01

    In this paper, a piano chords detector based on parallel interference cancellation (PIC) is presented. The proposed system makes use of the novel idea of modeling a segment of music as a third generation mobile communications signal, specifically, as a CDMA (Code Division Multiple Access) signal. The proposed model considers each piano note as a CDMA user in which the spreading code is replaced by a representative note pattern. The lack of orthogonality between the note patterns will make necessary to design a specific thresholding matrix to decide whether the PIC outputs correspond to the actual notes composing the chord or not. An additional stage that performs an octave test and a fifth test has been included that improves the error rate in the detection of these intervals that are specially difficult to detect. The proposed system attains very good results in both the detection of the notes that compose a chord and the estimation of the polyphony number.

  3. [Accession to the PIC/S and pharmaceutical quality system in Japan].

    Science.gov (United States)

    Katori, Noriko

    2014-01-01

    In March, 2012, Japan made the application for membership of the Pharmaceutical Inspection convention and Pharmaceutical Inspection Co-operation scheme (PIC/S) which is an international body of a GMP inspection. The globalization of pharmaceutical manufacturing and sales has been a driving force behind the decision to become a PIC/S member. For the application for membership, Japan's GMP inspectorate needs to fulfill PIC/S requirements, for example, the inspection organization has to have a quality system as a global standard. One of the other requirements is that the GMP inspectorate can access Official Medicines Control Laboratories (OMCL) having high analytical skills and also have a quality system based on ISO 17025. I would like to describe the process to make up a quality system in the National Institute of Health Sciences and also the circumstances around the PIC/S application in Japan.

  4. JPIC & How to make a PIC code

    CERN Document Server

    Wu, Hui-Chun

    2011-01-01

    Author developed the parallel fully kinetic particle-in-cell (PIC) code JPIC based on updated and advanced algorithms (e.g. numerical-dispersion-free electromagnetic field solver) for simulating laser plasma interactions. Basic technical points and hints of PIC programming and parallel programming by message passing interface (MPI) are reviewed. Most of contents come from Author's notes when writing up JPIC and experiences when using the code to solve different problems. Enough "how-to-do-it" information should help a new beginner to effectively build up his/her own PIC code. General advices on how to use a PIC code are also given.

  5. Mediator coordinates PIC assembly with recruitment of CHD1.

    Science.gov (United States)

    Lin, Justin J; Lehmann, Lynn W; Bonora, Giancarlo; Sridharan, Rupa; Vashisht, Ajay A; Tran, Nancy; Plath, Kathrin; Wohlschlegel, James A; Carey, Michael

    2011-10-15

    Murine Chd1 (chromodomain helicase DNA-binding protein 1), a chromodomain-containing chromatin remodeling protein, is necessary for embryonic stem (ES) cell pluripotency. Chd1 binds to nucleosomes trimethylated at histone 3 Lys 4 (H3K4me3) near the beginning of active genes but not to bivalent domains also containing H3K27me3. To address the mechanism of this specificity, we reproduced H3K4me3- and CHD1-stimulated gene activation in HeLa extracts. Multidimensional protein identification technology (MuDPIT) and immunoblot analyses of purified preinitiation complexes (PICs) revealed the recruitment of CHD1 to naive chromatin but enhancement on H3K4me3 chromatin. Studies in depleted extracts showed that the Mediator coactivator complex, which controls PIC assembly, is also necessary for CHD1 recruitment. MuDPIT analyses of CHD1-associated proteins support the recruitment data and reveal numerous components of the PIC, including Mediator. In vivo, CHD1 and Mediator are recruited to an inducible gene, and genome-wide binding of the two proteins correlates well with active gene transcription in mouse ES cells. Finally, coimmunoprecipitation of CHD1 and Mediator from cell extracts can be ablated by shRNA knockdown of a specific Mediator subunit. Our data support a model in which the Mediator coordinates PIC assembly along with the recruitment of CHD1. The combined action of the PIC and H3K4me3 provides specificity in targeting CHD1 to active genes.

  6. Notes on Lycocerus kiontochananus (Pic, 1921) and description of two new species of Lycocerus Gorham from China (Coleoptera, Cantharidae).

    Science.gov (United States)

    Yang, Yuxia; Yang, Xingke

    2014-03-11

    The Lycocerus kiontochananus species complex is revised; L. perroudi (Pic, 1937) stat. rev., originally in Cantharis, is resurrected from synonymy with L. kiontochananus (Pic, 1921); L. atropygidialis (Pic, 1937) stat. nov., originally in Cantharis, is upgraded from Cantharis perroudi var. atropygidialis Pic, 1937 and resurrected from synonymy with L. kiontochananus; L. kejvali Švihla, 2004 syn. nov. is considered as a junior synonym with L. kiontochananus. The male of L. perroudi and the female of L. jendeki Švihla, 2005 are described for the first time. Two new species are described under the names of L. metalliceps sp. nov. (China: Sichuan) and L. hainanus sp. nov. (China: Hainan).

  7. Designing embedded systems with 32-bit PIC microcontrollers and MikroC

    CERN Document Server

    Ibrahim, Dogan

    2013-01-01

    The new generation of 32-bit PIC microcontrollers can be used to solve the increasingly complex embedded system design challenges faced by engineers today. This book teaches the basics of 32-bit C programming, including an introduction to the PIC 32-bit C compiler. It includes a full description of the architecture of 32-bit PICs and their applications, along with coverage of the relevant development and debugging tools. Through a series of fully realized example projects, Dogan Ibrahim demonstrates how engineers can harness the power of this new technology to optimize their embedded design

  8. PICS: probabilistic inference for ChIP-seq.

    Science.gov (United States)

    Zhang, Xuekui; Robertson, Gordon; Krzywinski, Martin; Ning, Kaida; Droit, Arnaud; Jones, Steven; Gottardo, Raphael

    2011-03-01

    ChIP-seq combines chromatin immunoprecipitation with massively parallel short-read sequencing. While it can profile genome-wide in vivo transcription factor-DNA association with higher sensitivity, specificity, and spatial resolution than ChIP-chip, it poses new challenges for statistical analysis that derive from the complexity of the biological systems characterized and from variability and biases in its sequence data. We propose a method called PICS (Probabilistic Inference for ChIP-seq) for identifying regions bound by transcription factors from aligned reads. PICS identifies binding event locations by modeling local concentrations of directional reads, and uses DNA fragment length prior information to discriminate closely adjacent binding events via a Bayesian hierarchical t-mixture model. It uses precalculated, whole-genome read mappability profiles and a truncated t-distribution to adjust binding event models for reads that are missing due to local genome repetitiveness. It estimates uncertainties in model parameters that can be used to define confidence regions on binding event locations and to filter estimates. Finally, PICS calculates a per-event enrichment score relative to a control sample, and can use a control sample to estimate a false discovery rate. Using published GABP and FOXA1 data from human cell lines, we show that PICS' predicted binding sites were more consistent with computationally predicted binding motifs than the alternative methods MACS, QuEST, CisGenome, and USeq. We then use a simulation study to confirm that PICS compares favorably to these methods and is robust to model misspecification.

  9. Partial PIC-MRC Receiver Design for Single Carrier Block Transmission System over Multipath Fading Channels

    Directory of Open Access Journals (Sweden)

    Juinn-Horng Deng

    2012-01-01

    Full Text Available Single carrier block transmission (SCBT system has become one of the most popular modulation systems due to its low peak-to-average power ratio (PAPR, and it is gradually considered to be used for uplink wireless communication systems. In this paper, a low complexity partial parallel interference cancellation (PIC with maximum ratio combining (MRC technology is proposed to use for receiver to combat the intersymbol interference (ISI problem over multipath fading channel. With the aid of MRC scheme, the proposed partial PIC technique can effectively perform the interference cancellation and acquire the benefit of time diversity gain. Finally, the proposed system can be extended to use for multiple antenna systems to provide excellent performance. Simulation results reveal that the proposed low complexity partial PIC-MRC SIMO system can provide robust performance and outperform the conventional PIC and the iterative frequency domain decision feedback equalizer (FD-DFE systems over multipath fading channel environment.

  10. PIC Simulation of plasma detachment

    Science.gov (United States)

    Ishiguro, Seiji; Pianpanit, Theerasarn; Hasegawa, Hiroki; Kanno, Ryutaro

    2014-10-01

    The detached plasma, which is caused by gas puffing, has been proposed and it is the most promising way to reduce the heat load to the divertor plate of fusion oriented devices. Dynamical and kinetic behavior of the detached plasma is unresolved. So we are developing particle-in-cell simulation model with atomic processes such as line radiation, ionization, charge-exchange collision and recombination. As a first step, we have performed PIC simulation with Monte Carlo collisions, where spatial and velocity space distributions of charged particles, self-consistent electric field, and atomic processes such as ionization and charge exchange are included. Temperature decrease and density increase in front of the target is observed and electric potential structure along the axis is created. This work is performed with the support and under the auspices of NIFS Collaboration Research programs (NIFS14KNXN279 and 8 NIFS13KNSS038) and the Research Cooperation Program on Hierarchy and Holism in Natural Sciences at the NINS.

  11. Boltzmann Transport in Hybrid PIC HET Modeling

    Science.gov (United States)

    2015-07-01

    Paper 3. DATES COVERED (From - To) July 2015-July 2015 4. TITLE AND SUBTITLE Boltzmann transport in hybrid PIC HET modeling 5a. CONTRACT NUMBER In...produced a variety of self-consistent electron swarm codes, such as the Magboltz code, focused on directly solving the steady Boltzmann trans-port...Std. 239.18 Boltzmann transport in hybrid PIC HET modeling IEPC-2015- /ISTS-2015-b- Presented at Joint Conference of 30th International

  12. Programming 16-Bit PIC Microcontrollers in C Learning to Fly the PIC 24

    CERN Document Server

    Di Jasio, Lucio

    2011-01-01

    New in the second edition: * MPLAB X support and MPLAB C for the PIC24F v3 and later libraries * I2C™ interface * 100% assembly free solutions * Improved video, PAL/NTSC * Improved audio, RIFF files decoding * PIC24F GA1, GA2, GB1 and GB2 support   Most readers will associate Microchip's name with the ubiquitous 8-bit PIC microcontrollers but it is the new 16-bit PIC24F family that is truly stealing the scene. Orders of magnitude increases of performance, memory size and the rich peripheral set make programming these devices in C a must. This new guide by Microchip insid

  13. The Mediator complex and transcription regulation

    Science.gov (United States)

    Poss, Zachary C.; Ebmeier, Christopher C.

    2013-01-01

    The Mediator complex is a multi-subunit assembly that appears to be required for regulating expression of most RNA polymerase II (pol II) transcripts, which include protein-coding and most non-coding RNA genes. Mediator and pol II function within the pre-initiation complex (PIC), which consists of Mediator, pol II, TFIIA, TFIIB, TFIID, TFIIE, TFIIF and TFIIH and is approximately 4.0 MDa in size. Mediator serves as a central scaffold within the PIC and helps regulate pol II activity in ways that remain poorly understood. Mediator is also generally targeted by sequence-specific, DNA-binding transcription factors (TFs) that work to control gene expression programs in response to developmental or environmental cues. At a basic level, Mediator functions by relaying signals from TFs directly to the pol II enzyme, thereby facilitating TF-dependent regulation of gene expression. Thus, Mediator is essential for converting biological inputs (communicated by TFs) to physiological responses (via changes in gene expression). In this review, we summarize an expansive body of research on the Mediator complex, with an emphasis on yeast and mammalian complexes. We focus on the basics that underlie Mediator function, such as its structure and subunit composition, and describe its broad regulatory influence on gene expression, ranging from chromatin architecture to transcription initiation and elongation, to mRNA processing. We also describe factors that influence Mediator structure and activity, including TFs, non-coding RNAs and the CDK8 module. PMID:24088064

  14. Phototriggered sulfoxide isomerization in [Ru(pic)2(dmso)2].

    Science.gov (United States)

    Rachford, Aaron A; Petersen, Jeffrey L; Rack, Jeffrey J

    2007-08-14

    We report the characterization and photochemistry of a simple ruthenium coordination complex containing only picolinate (pic) and dmso, which exhibits a large isomerization quantum yield (Phi(SS-->OO) = 0.50) in various solvents. The picolinate ligands of [Ru(pic)(2)(dmso)(2)] are in a cis arrangement so that the carboxylate oxygen of one pic ligand (O1) is trans to the pyridine of the second picolinate (N2). One dmso ligand (S1) is trans to a pyridine nitrogen (N1), while the second dmso (S2) is trans to a carboxylate oxygen (O3). The cyclic voltammetry, (1)H NMR, IR, and UV-vis spectroscopy data suggest that while both dmso ligands isomerize photochemically, only one dmso ligand isomerizes electrochemically. Isomerization quantum yields for each dmso ligand differ by an order of magnitude (Phi(SS-->SO) = 0.46 and Phi(SO-->OO) = 0.036). In agreement with previous results, the isomerization quantum yield for each dmso is dependent on the ligand that is trans to the dmso.

  15. Electrostatic PIC with adaptive Cartesian mesh

    CERN Document Server

    Kolobov, Vladimir I

    2016-01-01

    We describe an initial implementation of an electrostatic Particle-in-Cell (ES-PIC) module with adaptive Cartesian mesh in our Unified Flow Solver framework. Challenges of PIC method with cell-based adaptive mesh refinement (AMR) are related to a decrease of the particle-per-cell number in the refined cells with a corresponding increase of the numerical noise. The developed ES-PIC solver is validated for capacitively coupled plasma, its AMR capabilities are demonstrated for simulations of streamer development during high-pressure gas breakdown. It is shown that cell-based AMR provides a convenient particle management algorithm for exponential multiplications of electrons and ions in the ionization events.

  16. Peroxydisulfate activation by [RuII(tpy)(pic)(H2O)]+. Kinetic, mechanistic and anti-microbial activity studies.

    Science.gov (United States)

    Chatterjee, Debabrata; Banerjee, Priyabrata; Bose, Jagadeesh C K; Mukhopadhyay, Sudit

    2012-03-07

    The oxidation of [Ru(II)(tpy)(pic)H(2)O](+) (tpy = 2,2',6',2''-terpyridine; pic(-) = picolinate) by peroxidisulfate (S(2)O(8)(2-)) as precursor oxidant has been investigated kinetically by UV-VIS, IR and EPR spectroscopy. The overall oxidation of Ru(II)- to Ru(IV)-species takes place in a consecutive manner involving oxidation of [Ru(II)(tpy)(pic)H(2)O](+) to [Ru(III)(tpy)(pic)(OH)](+), and its further oxidation of to the ultimate product [Ru(IV)(tpy)(pic)(O)](+) complex. The time course of the reaction was followed as a function of [S(2)O(8)(2-)], ionic strength (I) and temperature. Kinetic data and activation parameters are interpreted in terms of an outer-sphere electron transfer mechanism. Anti-microbial activity of Ru(II)(tpy)(pic)H(2)O](+) complex by inhibiting the growth of Escherichia coli DH5α in presence of peroxydisulfate has been explored, and the results of the biological studies have been discussed in terms of the [Ru(IV)(tpy)(pic)(O)](+) mediated cleavage of chromosomal DNA of the bacteria.

  17. GaAs Photonic Integrated Circuit (PIC) development for high performance communications

    Energy Technology Data Exchange (ETDEWEB)

    Sullivan, C.T.

    1998-03-01

    Sandia has established a foundational technology in photonic integrated circuits (PICs) based on the (Al,Ga,In)As material system for optical communication, radar control and testing, and network switching applications at the important 1.3{mu}m/1.55{mu}m wavelengths. We investigated the optical, electrooptical, and microwave performance characteristics of the fundamental building-block PIC elements designed to be as simple and process-tolerant as possible, with particular emphasis placed on reducing optical insertion loss. Relatively conventional device array and circuit designs were built using these PIC elements: (1) to establish a baseline performance standard; (2) to assess the impact of epitaxial growth accuracy and uniformity, and of fabrication uniformity and yield; (3) to validate our theoretical and numerical models; and (4) to resolve the optical and microwave packaging issues associated with building fully packaged prototypes. Novel and more complex PIC designs and fabrication processes, viewed as higher payoff but higher risk, were explored in a parallel effort with the intention of meshing those advances into our baseline higher-yield capability as they mature. The application focus targeted the design and fabrication of packaged solitary modulators meeting the requirements of future wideband and high-speed analog and digital data links. Successfully prototyped devices are expected to feed into more complex PICs solving specific problems in high-performance communications, such as optical beamforming networks for phased array antennas.

  18. Ce(IV)- and light-driven water oxidation by [Ru(terpy)(pic)3]2+ analogues: catalytic and mechanistic studies.

    Science.gov (United States)

    Duan, Lele; Xu, Yunhua; Tong, Lianpeng; Sun, Licheng

    2011-02-18

    A series of mononuclear ruthenium polypyridyl complexes [Ru(Mebimpy)(pic)(3)](PF(6))(2) (2; Mebimpy = 2,6-bis(1-methylbenzimidazol-2-yl)pyridine; pic = 4-picoline), Ru(bimpy)(pic)(3) (3; H(2)bimpy = 2,6-bis(benzimidazol-2-yl)pyridine), trans-[Ru(terpy)(pic)(2)Cl](PF(6)) (4; terpy = 2,2';6',2"-terpyridine), and trans-[Ru(terpy)(pic)(2)(OH(2))](ClO(4))(2) (5) are synthesized and characterized as analogues of the known Ru complex, [Ru(terpy)(pic)(3)](PF(6))(2) (1). The effect of the ligands on electronic and catalytic properties is studied and discussed. The negatively charged ligand, bimpy(2-), has a remarkable influence on the electrochemical events due to its strong electron-donating ability. The performance in light- and Ce(IV)-driven (Ce(IV) = Ce(NH(4))(2)(NO(3))(6)) water oxidation is successfully demonstrated. We propose that ligand exchange between pic and H(2)O occurs to form the real catalyst, a Ru-aqua complex. The synthesis and testing of trans-[Ru(terpy)(pic)(2)(OH(2))](ClO(4))(2) (5) confirmed our proposal. In addition, complex 5 possesses the best catalytic activity among these five complexes.

  19. Designing Embedded Systems with PIC Microcontrollers Principles and Applications

    CERN Document Server

    Wilmshurst, Tim

    2009-01-01

    PIC microcontrollers are used worldwide in commercial and industrial devices. The 8-bit PIC which this book focuses on is a versatile work horse that completes many designs. An engineer working with applications that include a microcontroller will no doubt come across the PIC sooner rather than later. It is a must to have a working knowledge of this 8-bit technology. This book takes the novice from introduction of embedded systems through to advanced development techniques for utilizing and optimizing the PIC family of microcontrollers in your device. To truly understand the PIC, assembly and

  20. Charge preserving high order PIC schemes

    Energy Technology Data Exchange (ETDEWEB)

    Londrillo, P., E-mail: pasquale.londrillo@oabo.inaf.i [INAF Bologna Osservatorio Astronomico (Italy); INFN Sezione Bologna (Italy); Benedetti, C.; Sgattoni, A.; Turchetti, G. [INFN Sezione Bologna (Italy); Dipartimento di Fisica dell' Universita di Bologna (Italy)

    2010-08-01

    In this paper we present some new results on our investigation aimed at extending to higher order (HOPIC) the classical PIC framework. After reviewing the basic resolution properties of the Runge-Kutta time integrator, coupled to fourth (sixth) order compact schemes for space derivatives in the Maxwell equations, we focus on the problem of extending charge conservation schemes to a general HOPIC framework. This issue represents the main contribution of the present work. We consider then a few numerical examples of 1D laser-plasma interaction in the under-dense and over-dense regimes relevant for ions acceleration, to test grid convergence and to compare HOPIC results with standard PIC schemes (LOPIC).

  1. Boot Loader para Microcontroladores PIC serie 18

    Directory of Open Access Journals (Sweden)

    Francisco Javier Villalobos Piña

    2006-01-01

    Full Text Available El presente trabajo expone el diseño de un boot loader, programa que permanece residente en un microcontrolador PIC18F452. Dicho programa permite grabar cualquier aplicación en el PIC sin el uso de un programador. Esta ventaja, no solo facilita el diseño de aplicaciones de control digital mediante la familia 18 de Microchip, sino que evita que el procesador se monte y desmonte continuamente, debido a lo cual, disminuyen los daños que por mal manejo pudiera sufrir el procesador. Se reporta igualmente el programa en visual Delphi, que permite leer, grabar y ejecutar los archivos hexadecimales del procesador, y probar la integridad del dispositivo

  2. Modified PIC Method for Sea Ice Dynamics

    Institute of Scientific and Technical Information of China (English)

    WANG Rui-xue; JI Shun-ying; SHEN Hung-tao; YUE Qian-jin

    2005-01-01

    The sea ice cover displays various dynamical characteristics such as breakup, rafting, and ridging under external forces. To model the ice dynamic process accurately, the effective numerical modeling method should be established. In this paper, a modified particle-in-cell (PIC) method for sea ice dynamics is developed coupling the finite difference (FD) method and smoothed particle hydrodynamics (SPH). In this method, the ice cover is first discretized into a series of Lagrangian ice particles which have their own sizes, thicknesses, concentrations and velocities. The ice thickness and concentration at Eulerian grid positions are obtained by interpolation with the Gaussian function from their surrounding ice particles. The momentum of ice cover is solved with FD approach to obtain the Eulerian cell velocity, which is used to estimate the ice particle velocity with the Gaussian function also. The thickness and concentration of ice particles are adjusted with particle mass density and smooth length, which are adjusted with the redistribution of ice particles. With the above modified PIC method, numerical simulations for ice motion in an idealized rectangular basin and the ice dynamics in the Bohai Sea are carried out. These simulations show that this modified PIC method is applicable to sea ice dynamics simulation.

  3. China's Entering into PIC/S and Participating in GMP Mutual Recognition Agreements%加入PIC/S与推动我国参与GMP国际互认

    Institute of Scientific and Technical Information of China (English)

    李琦

    2007-01-01

    目的:为我国加入药品检查协定和药品监察检查合作计划(PIC/S)提出对策.方法:结合PIC/S工作机制,分析加入PIC/S对我国参与GMP国际互认的意义,并就我国加入PIC/S的切入点进行分析和研究.结果与结论:加入PIC/S是可行的,此举对于我国GMP与有关国家互认和我国医药行业加速进入国际市场有非常重要的意义.

  4. PIC18FFLASH开发系统板

    Institute of Scientific and Technical Information of China (English)

    伊大成(编译)

    2005-01-01

    本文介绍一种通用的PIC电路开发系统.它可以用于最先进而强走的Microchip公司的PIC18F系列微控制器的开发工作.特别是用于PIC18F452的开发。目前PIC18F452已经成为18F系列事实上的标准。对于那些熟悉常用的PIC16F84和PIC16F87微控制器的开发人员采说,升级到更先进的PIC18F452系统是必然的选择。

  5. Implementación de bootloaders en microcontroladores PIC16 y PIC18 de microchip Inc.

    OpenAIRE

    Guadrón Gutiérrez, Ricardo Salvador; Guevara Vásquez, Juan José

    2015-01-01

    En este artículo se hace una descripción de las principales características de los programas bootloaders, los cuales se utilizan para programar microcontroladores PIC con una mínima cantidad de dispositivos electrónicos

  6. Microchip发布ROM PIC微处理器PIC 16CR

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Microchip日前发布的新型ROM PIC微控制器扩充已有的PIC16产品系列。这些Microchip PIC16及PIC18系列的新ROM微控制器包括:PIC16CR73,PIC16CR74.PIC16CR76与PIC16CR77(PIC16CR7X),新器件首次提供了对Microchip广为应用的PIC16F73,

  7. PIC BASED SOLAR CHARGING CONTROLLER FOR BATTERY

    Directory of Open Access Journals (Sweden)

    Mrs Jaya N. Ingole

    2012-02-01

    Full Text Available Solar resource is unlimited the government is trying to implement the use of Solar panels as an energy source in rural and sub urban areas for lighting the street lights, but the battery used to store the power gets affected due to overcharge & discharges. This paper presents the use of PIC16F72 based solar charger controller for controlling the overcharging and discharging of a solar cell. It works by continuously optimizing the interface between the solar array and battery. First, the variable supply is fixed at 12.8V dc—the voltage of a fully charged battery— and linked to the battery point of the circuit. Cut Off of battery from load voltage is 10.8 volt. A PIC16F72 for small size and inbuilt analog inputs is used to determine voltage level of battery and solar panel..It also describes how the disadvantages of analog circuit are overcome by this controller. The flow chart is also provided.

  8. Constructing a short form of the hierarchical personality inventory for children (HiPIC): the HiPIC-30.

    Science.gov (United States)

    Vollrath, Margarete E; Hampson, Sarah E; Torgersen, Svenn

    2016-05-01

    Children's personality traits are invaluable predictors of concurrent and later mental and physical health. Several validated longer inventories for assessing the widely recognized Five-Factor Model of personality in children are available, but short forms are scarce. This study aimed at constructing a 30-item form of the 144-item Hierarchical Personality Inventory for Children (HiPIC) (Mervielde & De Fruyt, ). Participants were 1543 children aged 6-12 years (sample 1) and 3895 children aged 8 years (sample 2). Sample 1 completed the full HiPIC, from which we constructed the HiPIC-30, and the Child Behaviour Checklist (Achenbach, ). Sample 2 completed the HiPIC-30. The HiPIC-30 personality domains correlated over r = .90 with the full HiPIC domains, had good Cronbach's alphas and correlated similarly with CBCL behaviour problems and gender as the full HiPIC. The factor structures of the HiPIC-30 were convergent across samples, but the imagination factor was not clear-cut. We conclude that the HiPIC-30 is a reliable and valid questionnaire for the Five-Factor personality traits in children. Copyright © 2016 John Wiley & Sons, Ltd.

  9. Perancangan Penampil Teks Berbasis Mikrokontroler PIC16F877A

    OpenAIRE

    Kandar, Aris

    2011-01-01

    Tulisan ini membahas tentang rancangan penampil teks berjalan yang menggunakan LED yang disusun berbentuk matriks berukuran 7x72 yang dinyalakan dengan metode multiplexing. Pengendali utama pada rangakaian menggunakan mikrokontroler PIC16F877A. Mikrokontroler PIC16F877A diprogram dengan menggunakan bahasa assembly. 040402064

  10. Metal Detector By Using PIC Microcontroller Interfacing With PC

    Directory of Open Access Journals (Sweden)

    Yin Min Theint

    2015-06-01

    Full Text Available Abstract This system proposes metal detector by using PIC microcontroller interfacing with PC. The system uses PIC microcontroller as the main controller whether the detected metal is ferrous metal or non-ferrous metal. Among various types of metal sensors and various types of metal detecting technologies concentric type induction coil sensor and VLF very low frequency metal detecting technology are used in this system. This system consists of two configurations Hardware configuration and Software configuration. The hardware components include induction coil sensors which senses the frequency changes of metal a PIC microcontroller personal computer PC buzzer light emitting diode LED and webcam. The software configuration includes a program controller interface. PIC MikroCprogramming language is used to implement the control system. This control system is based on the PIC 16F887 microcontroller.This system is mainly used in mining and high security places such as airport plaza shopping mall and governmental buildings.

  11. Nonlinear PIC simulation in a Penning trap

    Science.gov (United States)

    Lapenta, G.; Delzanno, G. L.; Finn, J. M.

    2002-01-01

    We study the nonlinear dynamics of a Penning trap plasma, including the effect of the finite length and end curvature of the plasma column. A new cylindrical PIC code, called KANDINSKY, has been implemented by using a new interpolation scheme. The principal idea is to calculate the volume of each cell from a particle volume, in the same manner as it is done for the cell charge. With this new method, the density is conserved along streamlines and artificial sources of compressibility are avoided. The code has been validated with a reference Eulerian fluid code. We compare the dynamics of three different models: a model with compression effects, the standard Euler model and a geophysical fluid dynamics model. The results of our investigation prove that Penning traps can really be used to simulate geophysical fluids.

  12. Spacecraft charging analysis with the implicit particle-in-cell code iPic3D

    Energy Technology Data Exchange (ETDEWEB)

    Deca, J.; Lapenta, G. [Centre for Mathematical Plasma Astrophysics, KU Leuven, Celestijnenlaan 200B bus 2400, 3001 Leuven (Belgium); Marchand, R. [Department of Physics, University of Alberta, Edmonton, Alberta T6G 2J1 (Canada); Markidis, S. [High Performance Computing and Visualization Department, KTH Royal Institute of Technology, Stockholm (Sweden)

    2013-10-15

    We present the first results on the analysis of spacecraft charging with the implicit particle-in-cell code iPic3D, designed for running on massively parallel supercomputers. The numerical algorithm is presented, highlighting the implementation of the electrostatic solver and the immersed boundary algorithm; the latter which creates the possibility to handle complex spacecraft geometries. As a first step in the verification process, a comparison is made between the floating potential obtained with iPic3D and with Orbital Motion Limited theory for a spherical particle in a uniform stationary plasma. Second, the numerical model is verified for a CubeSat benchmark by comparing simulation results with those of PTetra for space environment conditions with increasing levels of complexity. In particular, we consider spacecraft charging from plasma particle collection, photoelectron and secondary electron emission. The influence of a background magnetic field on the floating potential profile near the spacecraft is also considered. Although the numerical approaches in iPic3D and PTetra are rather different, good agreement is found between the two models, raising the level of confidence in both codes to predict and evaluate the complex plasma environment around spacecraft.

  13. A revision of the genus Macrolygistopterus Pic, 1929 (Coleoptera, Lycidae, Calochromini).

    Science.gov (United States)

    Ferreira, Vinicius S

    2016-04-21

    A taxonomic review of the Lycid genus Macrolygistopterus Pic, 1929 with illustrations of diagnostic characters, geographic distribution maps and an identification key to the species is presented. Also, a key to the world Calochromini is given. Of the 12 species of the genus, 9 were studied: M. succinctus (Latreille, 1811), M. quadricostatus (Buquet, 1842), M. caeruleus (Gorham, 1884), M. germaini Pic, 1930, M. grandjeani Pic, 1930, M. subparallelus Pic, 1930, M. testaceirostris Pic, 1930, M. simoni Pic, 1930 and M. kirschi Pic, 1931 were redescribed and their status as valid species is confirmed. The lectotypes and paralectotypes were designated for all those examined species. M. bilineatus (Pic, 1923), M. diversicornis Pic, 1930 and M. bipartitus Pic, 1933 remain as valid species since these specimens were not available for this study. M. succinctus var. scutelaris Pic, 1930 is proposed here as new junior synonym of M. succinctus (Latreille, 1811).

  14. Abstract Interpretation of PIC programs through Logic Programming

    DEFF Research Database (Denmark)

    Henriksen, Kim Steen; Gallagher, John Patrick

    2006-01-01

    , are applied to the logic based model of the machine. A small PIC microcontroller is used as a case study. An emulator for this microcontroller is written in Prolog, and standard programming transformations and analysis techniques are used to specialise this emulator with respect to a given PIC program....... The specialised emulator can now be further analysed to gain insight into the given program for the PIC microcontroller. The method describes a general framework for applying abstractions, illustrated here by linear constraints and convex hull analysis, to logic programs. Using these techniques on the specialised...

  15. Massive parallel 3D PIC simulation of negative ion extraction

    Science.gov (United States)

    Revel, Adrien; Mochalskyy, Serhiy; Montellano, Ivar Mauricio; Wünderlich, Dirk; Fantz, Ursel; Minea, Tiberiu

    2017-09-01

    The 3D PIC-MCC code ONIX is dedicated to modeling Negative hydrogen/deuterium Ion (NI) extraction and co-extraction of electrons from radio-frequency driven, low pressure plasma sources. It provides valuable insight on the complex phenomena involved in the extraction process. In previous calculations, a mesh size larger than the Debye length was used, implying numerical electron heating. Important steps have been achieved in terms of computation performance and parallelization efficiency allowing successful massive parallel calculations (4096 cores), imperative to resolve the Debye length. In addition, the numerical algorithms have been improved in terms of grid treatment, i.e., the electric field near the complex geometry boundaries (plasma grid) is calculated more accurately. The revised model preserves the full 3D treatment, but can take advantage of a highly refined mesh. ONIX was used to investigate the role of the mesh size, the re-injection scheme for lost particles (extracted or wall absorbed), and the electron thermalization process on the calculated extracted current and plasma characteristics. It is demonstrated that all numerical schemes give the same NI current distribution for extracted ions. Concerning the electrons, the pair-injection technique is found well-adapted to simulate the sheath in front of the plasma grid.

  16. Pseudo-3D PIC modeling of drift-induced spatial inhomogeneities in planar magnetron plasmas

    Science.gov (United States)

    Revel, A.; Minea, T.; Tsikata, S.

    2016-10-01

    A pseudo-3D modeling approach, based on a particle-in-cell (PIC)-Monte Carlo collisions algorithm, has been developed for the study of large- and short-scale organization of the plasma in a planar magnetron. This extension of conventional PIC modeling permits the observation of spontaneous organization of the magnetron plasma, under the influence of crossed electric and magnetic fields, into the well-known, large-scale regions of enhanced ionization and density known as spokes. The nature of complex three-dimensional electron trajectories around such structures, and non-uniform ionization within them, is revealed. This modeling provides direct numerical evidence for the existence of high-amplitude internal spoke electric fields, proposed in earlier works. A 3D phenomenological model, consistent with numerical results, is proposed. Electron density fluctuations in the megahertz range, with characteristics similar to the electron cyclotron drift instability experimentally identified in a recent Letter, are also found.

  17. Infinite Three-Dimensional Coordination Polymers: Synthesis and Structures of [Cd (4,4'-bpy)2 (H2O)2]n (pic)2n, [Zn (4,4'-bpy)2 (H2O)2 ]n-(pic)2n (H2O)2n, and [Zn (4,4'-bpy)2 (H2O)2]n (4,4'-bpy)n (H2O)n (pic)2n

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Three Complexes of the formula [ Cd (4,4'-bpy)2 (H2O)2 ]n (pic)2n (1), [ Zn (4,4'-bpy)2 (H2O)2 ]n-(pic)2n (H2O)2n (2) and [ Zn (4,4'-bpy)2 (H2O)2 ]n (4,4'-bpy)n (pic)2n (H2O)n (3) ( 4,4'-bpy = 4,4'-bipyridine; pic = picric anion ) have been synthesized and characterized by elemental analysis and single-crystal x-ray diffraction. They all have infinite three-dimensional network structure, crystallizing in the monoclinic space group C2/c (1) and Cc (2,3).

  18. IBIS/PICsIT in-flight performances

    CERN Document Server

    Cocco, G D; Celesti, E; Foschini, L; Gianotti, F; Labanti, C; Malaguti, G; Mauri, A; Rossi, E; Schiavone, F; Spizzichino, A; Stephen, J B; Traci, A; Trifoglio, M

    2003-01-01

    PICsIT (Pixellated Imaging CaeSium Iodide Telescope) is the high energy detector of the IBIS telescope on-board the INTEGRAL satellite. PICsIT operates in the gamma-ray energy range between 175 keV and 10 MeV, with a typical energy resolution of 10% at 1 MeV, and an angular resolution of 12 arcmin within a \\~100 square degree field of view, with the possibility to locate intense point sources in the MeV region at the few arcmin level. PICsIT is based upon a modular array of 4096 independent CsI(Tl) pixels, ~0.70 cm^2 in cross-section and 3 cm thick. In this work, the PICsIT on-board data handling and science operative modes are described. This work presents the in-flight performances in terms of background count spectra, sensitivity limit, and imaging capabilities.

  19. Pseudospectral Model for Hybrid PIC Hall-effect Thruster Simulation

    Science.gov (United States)

    2015-07-01

    1149. 8Goebel, D. M. and Katz, I., Fundamentals of Electric Propulsion : Ion and Hall Thrusters, John Wiley & Sons, Inc., 2008. 9Martin, R., J.W., K...Bilyeu, D., and Tran, J., “Dynamic Particle Weight Remapping in Hybrid PIC Hall -effect Thruster Simulation,” 34th Int. Electric Propulsion Conf...Paper 3. DATES COVERED (From - To) July 2015-July 2015 4. TITLE AND SUBTITLE Pseudospectral model for hybrid PIC Hall -effect thruster simulationect

  20. Programando en assembler a los microcontroladores RISC. PIC de microchips

    OpenAIRE

    Tito Flórez C.

    2011-01-01

    Programar en assembler a los PIC se hace relativamente sencillo, cuando se minimiza el número de instrucciones a unas pocas (14 para el PICI6C84). El funcionamiento de esas instrucciones se explica mediante ejemplos sencillos, y el funcionamiento del programa en conjunto se explica con un programa ejemplo. De igual forma se explica la forma como debe de ser quemado el PIC.

  1. Programando en assembler a los microcontroladores RISC. PIC de microchips

    Directory of Open Access Journals (Sweden)

    Tito Flórez C.

    2011-05-01

    Full Text Available Programar en assembler a los PIC se hace relativamente sencillo, cuando se minimiza el número de instrucciones a unas pocas (14 para el PICI6C84. El funcionamiento de esas instrucciones se explica mediante ejemplos sencillos, y el funcionamiento del programa en conjunto se explica con un programa ejemplo. De igual forma se explica la forma como debe de ser quemado el PIC.

  2. Discussion on Participation of PIC/S and Promotion of GMP and MRAs in China%加入PIC/S与推动我国GMP MRAs问题的探讨

    Institute of Scientific and Technical Information of China (English)

    梁毅; 林园园

    2006-01-01

    目的:为我国加入PIC/S提出对策.方法:结合PIC/S工作机制,就加入PIC/S的切入点进行分析研究.结论:加入PIC/S是可行的,此举对于我国GMP与有关国家MRAs和我国医药行业加速进入国际市场有非常重要的作用.

  3. Nonlinear PIC Simulations for Nonneutral Plasmas

    Science.gov (United States)

    Lapenta, Giovanni; Luca Delzanno, Gian; Finn, John M.

    2002-11-01

    We present nonlinear simulations of the low frequency dynamics of electrons in a Malmberg-Penning trap, including compressional and thermal effects [1,2]. First, we consider a 2D model where we assume the effective plasma length constant in time. In this framework, we further neglect the thermal effect on the velocity field, and show with the PIC code KANDINSKY that Penning traps could be used to perform geophysical fluid dynamics experiments [3]. We also observe that, due to the presence of the nonlinear m=1 instability, the initially hollow density profile becomes peaked, as in the experiments. Then, we show 2D results including thermal effects. In this case, the development of the m=1 instability is slowed since the equilibrium plasma length profile is closer to the integrable profile, namely the length profile for which there are no discrete unstable modes [4]. Finally, we present simulations of the 3D fluiddynamics model of Ref. [2]. In particular, we investigate the evolution of a m=1 perturbation for different electron temperatures, when compressional and thermal effects are included. [1] J.M. Finn, D. del-Castillo-Negrete, D.C. Barnes,Phys. Plasmas, 6, 3744, 1999. [2] G.G.M. Coppa, A. D'Angola, G.L. Delzanno, G. Lapenta, Phys. Plasmas, 8, 1133, 2001. [3] G.L. Delzanno, J.M. Finn, G. Lapenta, "Nonlinear Phase of the Compressional m=1 Diocotron Instability: Saturation and Analogy with Geophysical Fluid Dynamics", submitted to Phys. Plasmas. [4] G.L. Delzanno, V.I. Pariev, J.M. Finn, G. Lapenta, "Stability Analysis of Hollow Electron Columns Including Compression and Thermal Effects: Integrability Condition and Numerical Simulations", submitted to Phys. Plasmas.

  4. Electromagnetic PIC simulation with highly enhanced energy conservation

    CERN Document Server

    Yazdanpanah, J

    2011-01-01

    We have obtained an electromagnetic PIC (EM-PIC) algorithm based on time-space-extended particle in cell model. In this model particles are shaped objects extended over time and space around Lagrangian markers. Sources carried by these particles are weighted completely into centers and faces of time-space cells of simulation-domain. Weighting is obtained by implication of conservation of charge of shaped particles. By solving Maxwell's equations over source free zones of simulation grid we reduce solution of these equations to finding field values at nods of this grid. Major source of error in this model (and albeit other PIC models) is identified to be mismatching of particle marker location and location of its assigned sources in time and space. Relation of leapfrog scheme for integration of equations of motion with this discrepancy is investigated by evaluation of violation of energy conservation. We come in conclusion that instead of leapfrog we should integrate equations of motion simultaneously. Though ...

  5. Introduccion a los microcontroladores risc. -pics de microchips-

    OpenAIRE

    Tito Flórez C.

    2011-01-01

    Los microcontroladores han prestado una gran ayuda en muchos campos, de los cuales uno de los más conocidos es el control. Iniciarse en el campo de los microcontroladores requiere normalmente dedicarle una enorme cantidad de tiempo, debido, entre otros, a la facilidad de perderse en el mar de información contenida en sus manuales. Debido a la gran similitud que poseen los PIC con respecto a su arquitectura, conjunto de instrucciones y programación, se toma el PIC 16C84 como un buen prototipo ...

  6. SPEED CONTROL OF DC MOTOR WITH PIC 16F877

    OpenAIRE

    ÇOLAK, İlhami; Ramazan BAYINDIR

    2005-01-01

    In this study, a PI controlled separately excited direct current (DC) motor speed has been controlled using PIC 16F877 controller. In the PIC 16F877 programming as a PI controller, the speed of the motor is expected to follow the reference speed. Speed of the motor is measured by a tacho generator and then, the voltage applied to the motor is adjusted by a semiconductor power switch using pulse width modulation (PWM) technique. Drive circuit was tested with 0.9 kW DC motor. Experimental resul...

  7. Kit de pràctiques basat en microcontrolador PIC

    OpenAIRE

    Verdaguer Estarlich, Meritxell

    2013-01-01

    Aquest treball consisteix en el disseny i prototipat d‟un kit de pràctiques com a suport a la docència, basat en l‟arquitectura PIC. El microcontrolador escollit per a la implementació és el PIC18F4550, el qual reuneix les característiques necessàries per a la necessitat requerida. El kit compta amb diversos dispositius, els de sortida com són díodes LED, visualitzador 7 segments, display LCD; i d‟altres d‟entrada: teclat hexadecimal, interruptors, optoacobladors i un convertidor analòg...

  8. Kit de pràctiques basat en microcontrolador PIC

    OpenAIRE

    Verdaguer Estarlich, Meritxell

    2013-01-01

    Aquest treball consisteix en el disseny i prototipat d‟un kit de pràctiques com a suport a la docència, basat en l‟arquitectura PIC. El microcontrolador escollit per a la implementació és el PIC18F4550, el qual reuneix les característiques necessàries per a la necessitat requerida. El kit compta amb diversos dispositius, els de sortida com són díodes LED, visualitzador 7 segments, display LCD; i d‟altres d‟entrada: teclat hexadecimal, interruptors, optoacobladors i un convertidor analòg...

  9. Soft-PIC multiuser detection in MC-CDMA uplink system

    Institute of Scientific and Technical Information of China (English)

    Guo Li-li; Yuan Bing-bing

    2005-01-01

    It is necessary for an MC-CDMA uplink receiver to employ MUD (multiuser detection) in a frequency selective fading channel. After analyzing the algorithm of PIC(parallel interference cancellation) MUD, a novel MUD scheme, Soft-PIC (soft parallel interference cancellation) is proposed. Based on the reliability of each detected user signal in the former stage, this Soft-PIC detection scheme substitutes a soft decision of the variable for the hard decision in PIC scheme. Compared with the PIC scheme, it can reconstruct the interference signals more accurately and eliminate MAI(multiple access interference) in a more efficient way.PIC is one of the most practical schemes in numerous multiuser detection technologies. However, Soft-PIC as an improved PIC scheme deserves further study.

  10. Suppressing the Numerical Cherenkov Instability in FDTD PIC Codes

    CERN Document Server

    Godfrey, Brendan B

    2014-01-01

    A procedure for largely suppressing the numerical Cherenkov instability in finite difference time-domain (FDTD) particle-in-cell (PIC) simulations of cold, relativistic beams is derived, and residual growth rates computed and compared with WARP code simulation results. Sample laser-plasma acceleration simulation output is provided to further validate the new procedure.

  11. The PIC [Process Individualization Curriculum] Model: Structure with Humanistic Goals.

    Science.gov (United States)

    Gow, Doris T.

    This paper describes a curriculum design model to train research and development personnel under USOE-NIE funding. This design model, called PIC (Process Individualization Curriculum), was chosen for coverting on-campus courses to extra-mural self-instructional courses. The curriculum specialists who work with professors to individualize their…

  12. The PIC Youth Primer: Improving JTPA Programs for Youth.

    Science.gov (United States)

    Snedeker, Bonnie; And Others

    This guide for Private Industry Council (PIC) officers, members, and staff is written to assist in planning and overseeing effective programs for youth at risk in the local labor market using resources allocated under the Job Training Partnership Act (JTPA). Section I takes a broad view of the problem of building effective employability…

  13. EXPERIMENTAL INVESTIGATION OF PIC FORMATION IN CFC-12 INCINERATION

    Science.gov (United States)

    The report gives results of experiments to determine the effect of flame zone temperature on gas-phase flame formation and destruction of products of incomplete combustion (PICS) during dichlorodi-fluoromethane (CFC-12) incineration. The effect of water injection into the flame ...

  14. 46 CFR 13.301 - Original application for “Tankerman-PIC (Barge)” endorsement.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Original application for âTankerman-PIC (Barge)â... OFFICERS AND SEAMEN CERTIFICATION OF TANKERMEN Requirements for âTankerman-PIC (Barge)â Endorsement § 13.301 Original application for “Tankerman-PIC (Barge)” endorsement. Each applicant for a...

  15. Food-pics: an image database for experimental research on eating and appetite

    Directory of Open Access Journals (Sweden)

    Jens eBlechert

    2014-06-01

    Full Text Available Our current environment is characterized by the omnipresence of food cues. The sight and smell of real foods, but also graphically depictions of appetizing foods, can guide our eating behavior, for example, by eliciting food craving and influencing food choice. The relevance of visual food cues on human information processing has been demonstrated by a growing body of studies employing food images across the disciplines of psychology, medicine, and neuroscience. However, currently used food image sets vary considerably across laboratories and image characteristics (contrast, brightness, etc. and food composition (calories, macronutrients, etc. are often unspecified. These factors might have contributed to some of the inconsistencies of this research. To remedy this, we developed food-pics, a picture database comprising 568 food images and 315 non-food images along with detailed meta-data. A total of N = 1988 individuals with large variance in age and weight from German speaking countries and North America provided normative ratings of valence, arousal, palatability, desire to eat, recognizability and visual complexity. Furthermore, data on macronutrients (g, energy density (kcal, and physical image characteristics (color composition, contrast, brightness, size, complexity are provided. The food-pics image data base is freely available under the creative commons license with the hope that the set will facilitate standardization and comparability across studies and advance experimental research on the determinants of eating behavior.

  16. The Serine Protease Autotransporter Pic Modulates Citrobacter rodentium Pathogenesis and Its Innate Recognition by the Host.

    Science.gov (United States)

    Bhullar, Kirandeep; Zarepour, Maryam; Yu, Hongbing; Yang, Hong; Croxen, Matthew; Stahl, Martin; Finlay, B Brett; Turvey, Stuart E; Vallance, Bruce A

    2015-07-01

    Bacterial pathogens produce a number of autotransporters that possess diverse functions. These include the family of serine protease autotransporters of Enterobacteriaceae (SPATEs) produced by enteric pathogens such as Shigella flexneri and enteroaggregative Escherichia coli. Of these SPATEs, one termed "protein involved in colonization," or Pic, has been shown to possess mucinase activity in vitro, but to date, its role in in vivo enteric pathogenesis is unknown. Testing a pic null (ΔpicC) mutant in Citrobacter rodentium, a natural mouse pathogen, found that the C. rodentium ΔpicC strain was impaired in its ability to degrade mucin in vitro compared to the wild type. Upon infection of mice, the ΔpicC mutant exhibited a hypervirulent phenotype with dramatically heavier pathogen burdens found in intestinal crypts. ΔpicC mutant-infected mice suffered greater barrier disruption and more severe colitis and weight loss, necessitating their euthanization between 10 and 14 days postinfection. Notably, the virulence of the ΔpicC mutant was normalized when the picC gene was restored; however, a PicC point mutant causing loss of mucinase activity did not replicate the ΔpicC phenotype. Exploring other aspects of PicC function, the ΔpicC mutant was found to aggregate to higher levels in vivo than wild-type C. rodentium. Moreover, unlike the wild type, the C. rodentium ΔpicC mutant had a red, dry, and rough (RDAR) morphology in vitro and showed increased activation of the innate receptor Toll-like receptor 2 (TLR2). Interestingly, the C. rodentium ΔpicC mutant caused a degree of pathology similar to that of wild-type C. rodentium when infecting TLR2-deficient mice, showing that despite its mucinase activity, PicC's major role in vivo may be to limit C. rodentium's stimulation of the host's innate immune system.

  17. The reaction of [Fe(pic)3] with hydrogen peroxide: a UV-visible and EPR spectroscopic study (Hpic = picolinic acid).

    Science.gov (United States)

    Jain, Sneh L; Bhattacharyya, Pravat

    2005-08-21

    The Gif family of catalysts, based on an iron salt and O2 or H2O2 in pyridine, allows the oxygenation of cyclic saturated hydrocarbons to ketones and alcohols under mild conditions. The reaction between [Fe(pic)3] and hydrogen peroxide in pyridine under GoAgg(III)(Fe(III)/Hpic catalyst) conditions was investigated by UV-visible spectrophotometry. Reactions were monitored at 430 and 520 nm over periods ranging from a few minutes to several hours at 20 degrees C. A number of kinetically stable intermediates were detected, and their relevance to the processes involved in the assembly of the active GoAgg(III) catalyst was determined by measuring the kinetics in the presence and absence of cyclohexane. EPR measurements at 110 K using hydrogen peroxide and t-BuOOH as oxidants were used to further probe these intermediates. Our results indicate that in wet pyridine [Fe(pic)3] undergoes reversible dissociation of one picolinate ligand, establishing an equilibrium with [Fe(pic)2(py)(OH)]. Addition of aqueous hydrogen peroxide rapidly generates the high-spin complex [Fe(pic)2(py)(eta1-OOH)] from the labilised hydroxy species. Subsequently the hydroperoxy species undergoes homolysis of the Fe-O bond, generating HOO. and [Fe(pic)2(py)2], the active oxygenation catalyst.

  18. Low dimensional gyrokinetic PIC simulation by δf method

    Science.gov (United States)

    Chen, C. M.; Nishimura, Yasutaro; Cheng, C. Z.

    2015-11-01

    A step by step development of our low dimensional gyrokinetic Particle-in-Cell (PIC) simulation is reported. One dimensional PIC simulation of Langmuir wave dynamics is benchmarked. We then take temporal plasma echo as a test problem to incorporate the δf method. Electrostatic driftwave simulation in one dimensional slab geometry is resumed in the presence of finite density gradients. By carefully diagnosing contour plots of the δf values in the phase space, we discuss the saturation mechanism of the driftwave instabilities. A v∥ formulation is employed in our new electromagnetic gyrokinetic method by solving Helmholtz equation for time derivative of the vector potential. Electron and ion momentum balance equations are employed in the time derivative of the Ampere's law. This work is supported by Ministry of Science and Technology of Taiwan, MOST 103-2112-M-006-007 and MOST 104-2112-M-006-019.

  19. Introduccion a los microcontroladores RISC. -PICs de microchips-

    Directory of Open Access Journals (Sweden)

    Tito Flórez C.

    2011-08-01

    Full Text Available Los microcontroladores han prestado una gran ayuda en muchos campos, de los cuales uno de los más conocidos es el control. Iniciarse en el campo de los microcontroladores requiere normalmente dedicarle una enorme cantidad de tiempo, debido, entre otros, a la facilidad de perderse en el mar de información contenida en sus manuales. Debido a la gran similitud que poseen los PIC con respecto a su arquitectura, conjunto de instrucciones y programación, se toma el PIC 16C84 como un buen prototipo de microcontrolador, y se da la información más importante (con sus respectivos ejemplos, para poder ubicarse correctamente en el manejo de éstos.

  20. PICS: Simulations of Strong Gravitational Lensing in Galaxy Clusters

    CERN Document Server

    Li, Nan; Rangel, Esteban M; Florian, Michael K; Bleem, Lindsey E; Heitmann, Katrin; Habib, Salman; Fasel, Patricia

    2015-01-01

    Gravitational lensing has become one of the most powerful tools available for investigating the 'dark side' of the universe. Cosmological strong gravitational lensing, in particular, probes the properties of the dense cores of dark matter halos over decades in mass and offers the opportunity to study the distant universe at flux levels and spatial resolutions otherwise unavailable. Studies of strongly-lensed variable sources offer yet further scientific opportunities. One of the challenges in realizing the potential of strong lensing is to understand the statistical context of both the individual systems that receive extensive follow-up study, as well as that of the larger samples of strong lenses that are now emerging from survey efforts. Motivated by these challenges, we have developed an image-simulation pipeline, PICS (Pipeline for Images of Cosmological Strong lensing) to generate realistic strong gravitational lensing signals from group and cluster scale lenses. PICS uses a low-noise and unbiased densit...

  1. Comparing Visual Acuity Measured by Lea Symbols and Patti Pics.

    Science.gov (United States)

    Singman, Eric L; Matta, Noelle S; Tian, Jing; Silbert, David I

    2015-01-01

    There is little data validating most illiterate eye charts. Lea Symbols®, however, have been well validated in numerous studies. In this study, we compare the assessment of visual acuity employing both the Lea Symbol hanging wall Early Treatment Diabetic Retinopathy Study (ETDRS)-style chart and a similar Patti Pics® ETDRS-style chart in order to determine whether the two charts provide clinically similar data. We tested the vision of the right eyes of fifty-two consecutive patients. Patients were cooperative children or adults between the ages of 3 and 88 years (mean 58 years). We alternated the order of the chart used first. Patients were also categorized by age and by visual acuity. The visual acuities measured by the two charts were equal for 83% of the measurements (forty-three eyes). In 8% of eyes (four eyes), the visual acuity measured with the Lea Symbols was one line better than that measured by the Patti Pics; in 9% of eyes (five eyes), the acuity from the Patti Pics chart measured one line better than the Lea Symbols. There was no difference in measurements for either adults or children or among patients with different visual acuities. We believe this study will serve to provide useful information when choosing an eye chart to assess visual acuity in a clinic setting. Patti Pics performed similarly to Lea Symbols in adults and children tested in a multi-specialty ophthalmology practice. We suspect that it would also perform similarly in the primary care and school settings. © 2015 Board of regents of the University of Wisconsin System, American Orthoptic Journal, Volume 65, 2015, ISSN 0065-955X, E-ISSN 1553-4448.

  2. Linear study of global microinstabilities using spectral and PIC methods

    Energy Technology Data Exchange (ETDEWEB)

    Brunner, S.; Fivaz, M.; Vaclavik, J.; Appert, K.; Tran, T.M. [Ecole Polytechnique Federale, Lausanne (Switzerland). Centre de Recherche en Physique des Plasma (CRPP)

    1996-09-01

    A spectral as well as a time evolution PIC code are presently being developed to solve the linearized gyrokinetic equations for studying global microinstabilities in toroidal geometry. In many ways these two methods are complementary and therefore allow for valuable cross-checking and validation of the different approximations made. This parallel approach forms a firm basis for future studies of non-linear evolution or higher dimensional systems. (author) 7 figs., 18 refs.

  3. In flight calibrations of Ibis/PICsIT

    Energy Technology Data Exchange (ETDEWEB)

    Malaguti, G.; Di Cocco, G.; Foschini, L.; Stephen, J.B. [Istituto di Astrofisica Spaziale e Fisica Cosmica - IASF/CNR, Sezione di Bologne (Italy); Bazzano, A.; Ubertini, P. [Istituto di Astrofisica Spaziale e Fisica Cosmica - IASF/CNR, Roma (Italy); Bird, A.J. [Southampton Univ., School of Physics and Astronomy (United Kingdom); Laurent, P. [CEA Saclay - Sap, 91 - Gif sur Yvette (France); Segreto, A. [Istituto di Astrofisica Spaziale e Fisica Cosmica - IASF/CNR, Sezione di Palermo (Italy)

    2003-11-01

    PICsIT (Pixellated Imaging Caesium Iodide Telescope) is the high energy detector of the IBIS telescope on-board the INTEGRAL satellite. It consists of 4096 independent detection units, {approx} 0.7 cm{sup 2} in cross-section, operating in the energy range between 175 keV and 10 MeV. The intrinsically low signal to noise ratio in the gamma-ray astronomy domain implies very long observations, lasting 10{sup 5}- 10{sup 6} s. Moreover, the image formation principle on which PICsIT works is that of coded imaging in which the entire detection plane contributes to each decoded sky pixel. For these two main reasons, the monitoring, and possible correction, of the spatial and temporal non-uniformity of pixel performances, especially in terms of gain and energy resolution, is of paramount importance. The IBIS on-board {sup 22}Na calibration source allows the calibration of each pixel at an accuracy of <0.5% by integrating the data from a few revolutions at constant temperature. The two calibration lines, at 511 and 1275 keV, allow also the measurement and monitoring of the PICsIT energy resolution which proves to be very stable at {approx} 19% and {approx} 9% (FWHM) respectively, and consistent with the values expected analytical predictions checked against pre-launch tests. (authors)

  4. Validation of RF CCP Discharge Model against Experimental Data using PIC Method

    Science.gov (United States)

    Icenhour, Casey; Kummerer, Theresa; Green, David L.; Smithe, David; Shannon, Steven

    2014-10-01

    The particle-in-cell (PIC) simulation method is a well-known standard for the simulation of laboratory plasma discharges. Using parallel computation on the Titan supercomputer at Oak Ridge National Laboratory (ORNL), this research is concerned with validation of a radio-frequency (RF) capacitively-coupled plasma (CCP) discharge PIC model against previously obtained experimental data. The plasma sources under simulation are 10--100 mTorr argon plasmas with a 13 MHz source and 27 MHz source operating at 50--200 W in both pulse and constant power conditions. Plasma parameters of interest in the validation include peak electron density, electron temperature, and RF plasma sheath voltages and thicknesses. The plasma is modeled utilizing the VSim plasma simulation tool, developed by the Tech-X Corporation. The implementation used here is a two-dimensional electromagnetic model, with corresponding external circuit model of the experimental setup. The goal of this study is to develop models for more complex RF plasma systems utilizing highly parallel computing technologies and methodology. This work is carried out with the support of Oak Ridge National Laboratory and the Tech-X Corporation.

  5. Electro pneumatic trainer embedded with programmable integrated circuit (PIC) microcontroller and graphical user interface platform for aviation industries training purposes

    Science.gov (United States)

    Burhan, I.; Azman, A. A.; Othman, R.

    2016-10-01

    An electro pneumatic trainer embedded with programmable integrated circuit (PIC) microcontroller and Visual Basic (VB) platform is fabricated as a supporting tool to existing teaching and learning process, and to achieve the objectives and learning outcomes towards enhancing the student's knowledge and hands-on skill, especially in electro pneumatic devices. The existing learning process for electro pneumatic courses conducted in the classroom does not emphasize on simulation and complex practical aspects. VB is used as the platform for graphical user interface (GUI) while PIC as the interface circuit between the GUI and hardware of electro pneumatic apparatus. Fabrication of electro pneumatic trainer interfacing between PIC and VB has been designed and improved by involving multiple types of electro pneumatic apparatus such as linear drive, air motor, semi rotary motor, double acting cylinder and single acting cylinder. Newly fabricated electro pneumatic trainer microcontroller interface can be programmed and re-programmed for numerous combination of tasks. Based on the survey to 175 student participants, 97% of the respondents agreed that the newly fabricated trainer is user friendly, safe and attractive, and 96.8% of the respondents strongly agreed that there is improvement in knowledge development and also hands-on skill in their learning process. Furthermore, the Lab Practical Evaluation record has indicated that the respondents have improved their academic performance (hands-on skills) by an average of 23.5%.

  6. Oxygen spectroscopy and polarization-dependent imaging contrast (PIC)-mapping of calcium carbonate minerals and biominerals.

    Science.gov (United States)

    DeVol, Ross T; Metzler, Rebecca A; Kabalah-Amitai, Lee; Pokroy, Boaz; Politi, Yael; Gal, Assaf; Addadi, Lia; Weiner, Steve; Fernandez-Martinez, Alejandro; Demichelis, Raffaella; Gale, Julian D; Ihli, Johannes; Meldrum, Fiona C; Blonsky, Adam Z; Killian, Christopher E; Salling, C B; Young, Anthony T; Marcus, Matthew A; Scholl, Andreas; Doran, Andrew; Jenkins, Catherine; Bechtel, Hans A; Gilbert, Pupa U P A

    2014-07-17

    X-ray absorption near-edge structure (XANES) spectroscopy and spectromicroscopy have been extensively used to characterize biominerals. Using either Ca or C spectra, unique information has been obtained regarding amorphous biominerals and nanocrystal orientations. Building on these results, we demonstrate that recording XANES spectra of calcium carbonate at the oxygen K-edge enables polarization-dependent imaging contrast (PIC) mapping with unprecedented contrast, signal-to-noise ratio, and magnification. O and Ca spectra are presented for six calcium carbonate minerals: aragonite, calcite, vaterite, monohydrocalcite, and both hydrated and anhydrous amorphous calcium carbonate. The crystalline minerals reveal excellent agreement of the extent and direction of polarization dependences in simulated and experimental XANES spectra due to X-ray linear dichroism. This effect is particularly strong for aragonite, calcite, and vaterite. In natural biominerals, oxygen PIC-mapping generated high-magnification maps of unprecedented clarity from nacre and prismatic structures and their interface in Mytilus californianus shells. These maps revealed blocky aragonite crystals at the nacre-prismatic boundary and the narrowest calcite needle-prisms. In the tunic spicules of Herdmania momus, O PIC-mapping revealed the size and arrangement of some of the largest vaterite single crystals known. O spectroscopy therefore enables the simultaneous measurement of chemical and orientational information in CaCO3 biominerals and is thus a powerful means for analyzing these and other complex materials. As described here, PIC-mapping and spectroscopy at the O K-edge are methods for gathering valuable data that can be carried out using spectromicroscopy beamlines at most synchrotrons without the expense of additional equipment.

  7. 3D Printing of Ultratough Polyion Complex Hydrogels.

    Science.gov (United States)

    Zhu, Fengbo; Cheng, Libo; Yin, Jun; Wu, Zi Liang; Qian, Jin; Fu, Jianzhong; Zheng, Qiang

    2016-11-16

    Polyion complex (PIC) hydrogels have been proposed as promising engineered soft materials due to their high toughness and good processability. In this work, we reported manufacturing of complex structures with tough PIC hydrogels based on three-dimensional (3D) printing technology. The strategy relies on the distinct strength of ionic bonding in PIC hydrogels at different stages of printing. In concentrated saline solution, PIC forms viscous solution, which can be directly extruded out of a nozzle into water, where dialyzing out of salt and counterions results in sol-gel transition to form tough physical PIC gel with intricate structures. The printability of PIC solutions was systematically investigated by adjusting the PIC material formula and printing parameters in which proper viscosity and gelation rate were found to be key factors for successful 3D printing. Uniaxial tensile tests were performed to printed single fibers and multilayer grids, both exhibiting distinct yet controllable strength and toughness. More complex 3D structures with negative Poisson's ratio, gradient grid, and material anisotropy were constructed as well, demonstrating the flexible printability of PIC hydrogels. The methodology and capability here provide a versatile platform to fabricate complex structures with tough PIC hydrogels, which should broaden the use of such materials in applications such as biomedical devices and artificial tissues.

  8. A new species of Pseudopyrochroa Pic, 1906 (Coleoptera: Pyrochroidae: Pyrochroinae) from the Mae Chaem District, Thailand.

    Science.gov (United States)

    Young, Daniel K

    2014-04-02

    A new species of the fire-colored beetle genus Pseudopyrochroa Pic, 1906, is described from the Mae Chaem District, Chiang Mai Province, Thailand. The new species, Pseudopyrochroa inthanonensis sp. nov., is superficially similar to Pseudopyrochroa basalis (Pic), Pseudopyrochroa cardoni (Fairmaire) and Pseudopyrochroa fainanensis (Pic) by virtue of body color, antennal form and prothoracic shape. It is the second species of the genus known from Thailand, the other being Pseudopyrochroa diversicornis (Blair).

  9. Study of negative hydrogen ion beam optics using the 3D3V PIC model

    Energy Technology Data Exchange (ETDEWEB)

    Miyamoto, K., E-mail: kmiyamot@naruto-u.ac.jp [Naruto University of Education, 748 Nakashima, Takashima, Naruto-cho, Naruto-shi, Tokushima, 772-8502 (Japan); Nishioka, S.; Goto, I.; Hatayama, A. [Faculty of Science and Technology, Keio University, 3-14-1, Hiyoshi, Kohoku-ku, Yokohama, 223-8522 (Japan); Hanada, M.; Kojima, A. [Japan Atomic Energy Agency, 801-1,Mukoyama, Naka, 319-0913 (Japan)

    2015-04-08

    The mechanism of negative ion extraction under real conditions with the complex magnetic field is studied by using the 3D PIC simulation code. The extraction region of the negative ion source for the negative ion based neutral beam injection system in fusion reactors is modelled. It is shown that the E x B drift of electrons is caused by the magnetic filter and the electron suppression magnetic field, and the resultant asymmetry of the plasma meniscus. Furthermore, it is indicated that that the asymmetry of the plasma meniscus results in the asymmetry of negative ion beam profile including the beam halo. It could be demonstrated theoretically that the E x B drift is not significantly weakened by the elastic collisions of the electrons with neutral particles.

  10. 2D arc-PIC code description: methods and documentation

    CERN Document Server

    Timko, Helga

    2011-01-01

    Vacuum discharges are one of the main limiting factors for future linear collider designs such as that of the Compact LInear Collider. To optimize machine efficiency, maintaining the highest feasible accelerating gradient below a certain breakdown rate is desirable; understanding breakdowns can therefore help us to achieve this goal. As a part of ongoing theoretical research on vacuum discharges at the Helsinki Institute of Physics, the build-up of plasma can be investigated through the particle-in-cell method. For this purpose, we have developed the 2D Arc-PIC code introduced here. We present an exhaustive description of the 2D Arc-PIC code in two parts. In the first part, we introduce the particle-in-cell method in general and detail the techniques used in the code. In the second part, we provide a documentation and derivation of the key equations occurring in the code. The code is original work of the author, written in 2010, and is therefore under the copyright of the author. The development of the code h...

  11. In-flight calibrations of IBIS/PICsIT

    CERN Document Server

    Malaguti, G; Bird, A J; Cocco, G D; Foschini, L; Laurent, P; Segreto, A; Stephen, J B; Ubertini, P

    2003-01-01

    PICsIT (Pixellated Imaging CaeSium Iodide Telescope) is the high energy detector of the IBIS telescope on-board the INTEGRAL satellite. It consists of 4096 independent detection units, ~0.7 cm^2 in cross-section, operating in the energy range between 175 keV and 10 MeV. The intrinsically low signal to noise ratio in the gamma-ray astronomy domain implies very long observations, lasting 10^5-10^6 s. Moreover, the image formation principle on which PICsIT works is that of coded imaging in which the entire detection plane contributes to each decoded sky pixel. For these two main reasons, the monitoring, and possible correction, of the spatial and temporal non-uniformity of pixel performances, expecially in terms of gain and energy resolution, is of paramount importance. The IBIS on-board 22Na calibration source allows the calibration of each pixel at an accuracy of <0.5% by integrating the data from a few revolutions at constant temperature. The two calibration lines, at 511 and 1275 keV, allow also the measu...

  12. PICsIT a position sensitive detector for space applications

    CERN Document Server

    Labanti, C; Ferriani, S; Ferro, G; Malaguti, G; Mauri, A; Rossi, E; Schiavone, F; Stephen, J B; Traci, A; Visparelli, D

    2002-01-01

    Pixellated Imaging CsI Telescope (PICsIT) is the high energy detector plane of Imager on Board INTEGRAL Satellite (IBIS), one of the main instruments on board the International Gamma-Ray Astrophysics Laboratory (INTEGRAL) satellite that will be launched in the year 2001. It consists of 4096 CsI(Tl) individual detector elements and operates in the energy range from 120 to 10,000 keV. PICsIT is made up of 8 identical modules, each housing 512 scintillating crystals coupled to PIN photodiodes (PD). Each crystal, 30 mm long and with a cross-section of 8.55x8.55 mm sup 2 , is wrapped with a white diffusing coating and then inserted into an aluminium crate. In order to have a compact design, two electronic boards, mounted directly below the crystal/PD assembly, host both the Analogue and Digital Front-End Electronics (FEE). The behaviour of the read-out FEE has a direct impact on the performance of the whole detector in terms of lower energy threshold, energy resolution and event time tagging. Due to the great numb...

  13. PIC Simulation of Relativistic Electromagnetic Plasma Expansion with Radiation Damping

    Science.gov (United States)

    Noguchi, Koichi; Liang, Edison; Wilks, Scott

    2004-11-01

    One of the unsolved problems in astrophysics is the acceleration of nonthermal high-energy particles. Nonthermal radiation is observed from pulsars, blazers, gamma-ray bursts and black holes. Recently, a new mechanism of relativistic nonthermal particle acceleration, called the Diamagnetic Relativistic Pulse Accelerator(DRPA), discovered using multi-dimensional Particle-in-Cell(PIC) simulations. When a plasma-loaded electromagnetic pulse expands relativistically, the self-induced drift current creates ponderomotive trap, which drags only the fast particles in the trap and leave slow ones behind. Here we study the effect of radiation on an electron-positron plasma accelerated by the DRPA, by introducing the radiation force in our 2D PIC code. In the radiation case, particles are accelerated by the EM pulse but decelerated by the radiation reaction simultaneously, whereas particles are accelerated indefinitely in the non-radiation case. We find that even with the radiation dumping the DRPA mechanism remains robust and particles are accelerated to over γ>100. After the simulation reaches the quasi-equilibrium state, kinetic energy becomes constant, and field energy is converted to radiation using particles as the transfer agent. We will also produce sample light waves of the radiation output.

  14. Evaluation of the Aleph PIC Code on Benchmark Simulations

    Science.gov (United States)

    Boerner, Jeremiah; Pacheco, Jose; Grillet, Anne

    2016-09-01

    Aleph is a massively parallel, 3D unstructured mesh, Particle-in-Cell (PIC) code, developed to model low temperature plasma applications. In order to verify and validate performance, Aleph is benchmarked against a series of canonical problems to demonstrate statistical indistinguishability in the results. Here, a series of four problems is studied: Couette flows over a range of Knudsen number, sheath formation in an undriven plasma, the two-stream instability, and a capacitive discharge. These problems respectively exercise collisional processes, particle motion in electrostatic fields, electrostatic field solves coupled to particle motion, and a fully coupled reacting plasma. Favorable comparison with accepted results establishes confidence in Aleph's capability and accuracy as a general purpose PIC code. Finally, Aleph is used to investigate the sensitivity of a triggered vacuum gap switch to the particle injection conditions associated with arc breakdown at the trigger. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

  15. Boltzmann electron PIC simulation of the E-sail effect

    CERN Document Server

    Janhunen, Pekka

    2015-01-01

    The solar wind electric sail (E-sail) is a planned in-space propulsion device that uses the natural solar wind momentum flux for spacecraft propulsion with the help of long, charged, centrifugally stretched tethers. The problem of accurately predicting the E-sail thrust is still somewhat open, however, due to a possible electron population trapped by the tether. Here we develop a new type of particle-in-cell (PIC) simulation for predicting E-sail thrust. In the new simulation, electrons are modelled as a fluid, hence resembling hydrid simulation, but in contrast to normal hybrid simulation, the Poisson equation is used as in normal PIC to calculate the self-consistent electrostatic field. For electron-repulsive parts of the potential, the Boltzmann relation is used. For electron-attractive parts of the potential we employ a power law which contains a parameter that can be used to control the number of trapped electrons. We perform a set of runs varying the parameter and select the one with the smallest number...

  16. Sign Language to Speech Translation System Using PIC Microcontroller

    Directory of Open Access Journals (Sweden)

    Gunasekaran. K

    2013-04-01

    Full Text Available The advancement in embedded system, provides a space to design and develop a sign language translator system to assist the dumb people. This paper mainly addresses to facilitate dumb person's lifestyle. Dumb people throughout the world use sign language to communicate with others, this is possible for those who has undergone special trainings. Common people also face difficult to understand the gesture language. To overcome these real time issues, this system is developed. Whenever the proposed system senses any sign language, it plays corresponding recorded voice. This reduces the communication gap between dumb and ordinary people. This proposed model consist of four modules, they are sensing unit, processing unit, voice storage unit and wireless communication unit. It is achieved by integrating flux sensor and APR9600 with PIC16F877A. The flux sensors are placed in gloves, which respond to gesture. By using suitable circuit response of the sensor is given to the microcontroller based on the response microcontroller plays the recorded voice using APR9600. A snapshot of the entire system, advantage over existing methods and simulation output of the process is discussed in this work. Thissystem offers high reliability and fast response. This method is more precise on hand movement and different languages can be installed without altering the code in PIC microcontroller.

  17. PIC microcontroller-based RF wireless ECG monitoring system.

    Science.gov (United States)

    Oweis, R J; Barhoum, A

    2007-01-01

    This paper presents a radio-telemetry system that provides the possibility of ECG signal transmission from a patient detection circuit via an RF data link. A PC then receives the signal through the National Instrument data acquisition card (NIDAQ). The PC is equipped with software allowing the received ECG signals to be saved, analysed, and sent by email to another part of the world. The proposed telemetry system consists of a patient unit and a PC unit. The amplified and filtered ECG signal is sampled 360 times per second, and the A/D conversion is performed by a PIC16f877 microcontroller. The major contribution of the final proposed system is that it detects, processes and sends patients ECG data over a wireless RF link to a maximum distance of 200 m. Transmitted ECG data with different numbers of samples were received, decoded by means of another PIC microcontroller, and displayed using MATLAB program. The designed software is presented in a graphical user interface utility.

  18. Pulsar magnetosphere: a new view from PIC simulations

    Science.gov (United States)

    Brambilla, Gabriele; Kalapotharakos, Constantions; Timokhin, Andrey; Harding, Alice; Kazanas, Demosthenes

    2017-01-01

    Pulsar emission is produced by charged particles that are accelerated as they flow in the star's magnetosphere. The magnetosphere is populated by electrons and positrons while the physical conditions are characterized by the so called force-free regime. However, the magnetospheric plasma configuration is still unknown, besides some general features, which inhibits the understanding of the emission generation. Here we show the closest to force-free solution ever obtained with a particle-in-cell (PIC) code. The importance of obtaining a force-free solution with PIC is that we can understand how the different particle species support the corresponding magnetosphere structure. Moreover, some aspects of the emission generation are captured. These are the necessary steps to go toward a self consistent modeling of the magnetosphere, connecting the microphysics of the pair plasma to its macroscopic quantities. Understanding the pulsar magnetosphere is essential for interpreting the broad neutron star phenomenology (young pulsars, magnetars, millisecond pulsars, etc.). The study of these plasma physics processes is also crucial for putting limits on the ability of these objects to accelerate particles.

  19. Spatial resolution of a μPIC-based neutron imaging detector

    Energy Technology Data Exchange (ETDEWEB)

    Parker, J.D., E-mail: jparker@cr.scphys.kyoto-u.ac.jp [Department of Physics, Graduate School of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502 (Japan); Harada, M. [Materials and Life Science Facility Division, Japan Atomic Energy Agency (JAEA), Tokai, Ibaraki 319-1195 (Japan); Hattori, K.; Iwaki, S.; Kabuki, S.; Kishimoto, Y.; Kubo, H.; Kurosawa, S.; Matsuoka, Y.; Miuchi, K.; Mizumoto, T.; Nishimura, H. [Department of Physics, Graduate School of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502 (Japan); Oku, T. [Materials and Life Science Facility Division, Japan Atomic Energy Agency (JAEA), Tokai, Ibaraki 319-1195 (Japan); Sawano, T. [Department of Physics, Graduate School of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502 (Japan); Shinohara, T.; Suzuki, J. [Materials and Life Science Facility Division, Japan Atomic Energy Agency (JAEA), Tokai, Ibaraki 319-1195 (Japan); Takada, A.; Tanimori, T.; Ueno, K. [Department of Physics, Graduate School of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502 (Japan)

    2013-10-21

    We present a detailed study of the spatial resolution of our time-resolved neutron imaging detector utilizing a new neutron position reconstruction method that improves both spatial resolution and event reconstruction efficiency. Our prototype detector system, employing a micro-pattern gaseous detector known as the micro-pixel chamber (μPIC) coupled with a field-programmable-gate-array-based data acquisition system, combines 100μm-level spatial and sub-μs time resolutions with excellent gamma rejection and high data rates, making it well suited for applications in neutron radiography at high-intensity, pulsed neutron sources. From data taken at the Materials and Life Science Experimental Facility within the Japan Proton Accelerator Research Complex (J-PARC), the spatial resolution was found to be approximately Gaussian with a sigma of 103.48±0.77μm (after correcting for beam divergence). This is a significant improvement over that achievable with our previous reconstruction method (334±13μm), and compares well with conventional neutron imaging detectors and with other high-rate detectors currently under development. Further, a detector simulation indicates that a spatial resolution of less than 60μm may be possible with optimization of the gas characteristics and μPIC structure. We also present an example of imaging combined with neutron resonance absorption spectroscopy. -- Highlights: • Neutron imaging detector with micro-pattern gaseous detector and {sup 3}He was developed. • Detector combines imaging with energy by time-of-flight and high-rate capability. • Detector features 18% efficiency, 0.6μs time resolution, and γ sensitivity <10{sup −12}. • New analysis method with template fit achieves spatial resolution of nearly 100μm. • Simulation study indicates improvement to ∼60μm after optimization.

  20. Review and Recent Advances in PIC Modeling of Relativistic Beams and Plasmas

    CERN Document Server

    Godfrey, Brendan B

    2014-01-01

    Particle-in-Cell (PIC) simulation codes have wide applicability to first-principles modeling of multidimensional nonlinear plasma phenomena, including wake-field accelerators. This review addresses both finite difference and pseudo-spectral PIC algorithms, including numerical instability suppression and generalizations of the spectral field solver.

  1. Planning, Management and Evaluation: Realizing PIC Potential. Private Industry Council Guide. Working Draft.

    Science.gov (United States)

    National Alliance of Business, Inc., Washington, DC.

    This Planning, Management, and Evaluation (PME) guide was developed by the National Alliance of Business as part of its program of management assistance for Private Industry Councils (PICs). The guide is a tool which PICs can use to improve their capability to plan, manage, and evaluate the programs which they administer, and to establish locally…

  2. Preparation of PLLA/bpV(pic) microspheres and their effect on nerve cells.

    Science.gov (United States)

    Lin, Qiang; Chen, Hai-yun; Li, Hao-shen; Cai, Yang-ting

    2014-02-01

    In this study, we prepared PLLA/bpV(pic) microspheres, a bpV(pic) controlled release system and examined their ability to protect nerve cells and promote axonal growth. PLLA microspheres were prepared by employing the o/w single emulsification-evaporation technique. Neural stem cells and dorsal root ganglia were divided into 3 groups in terms of the treatment they received: a routine medium group (cultured in DMEM), a PLLA microsphere group (DMEM containing PLLA microspheres alone) and a PLLA/bpV(pic) group [DMEM containing PLLA/bpV(pic) microspheres]. The effects of PLLA/bpV(pic) microspheres were evaluated by the live-dead test and measurement of axonal length. Our results showed that PLLA/bpV(pic) granulation rate was (88.2±5.6)%; particle size was (16.8±3.1)%, drug loading was (4.05±0.3)%; encapsulation efficiency was (48.5±1.8)%. The release time lasted for 30 days. In PLLA/bpV(pic) microsphere group, the cell survival rate was (95.2 ±4.77)%, and the length of dorsal root ganglion (DRG) was 718±95 μm, which were all significantly greater than those in ordinary routine medium group and PLLA microsphere group. This preliminary test results showed the PLLA/bpV(pic) microspheres were successfully prepared and they could promote the survival and growth of neural cells in DRG.

  3. PIC. Profile of Interaction in the Classroom. A Quick Feedback of Interaction Analysis.

    Science.gov (United States)

    Brunner, Ellen

    The Profile of Interaction in the Classroom (PIC) is a short-cut method of interaction analysis that can provide the quick feedback essential to effective supervision of instruction. And because the PIC contains a record of all the behaviors that occurred in the classroom, as well as the sequence, the data may be used to build a traditional…

  4. Micro-PIC. A Simple Form of the Profile of Interaction in the Classroom.

    Science.gov (United States)

    Forbes, Joan

    The Profile of Interaction in the Classroom (PIC) is a feedback method of interaction analysis, based on the Flanders System, created for supervisors of pre-service and in-service teacher education. The Micro-PIC is an abbreviated simplified form for analysis of shorter periods of interaction, particularly in microteaching. The Micro-PIC…

  5. Screening Preschoolers with Special Problems: Use of the Personality Inventory for Children (PIC).

    Science.gov (United States)

    Keenan, P. A.; Lachar, David

    The Personality Inventory for Children (PIC) is an objectively scored, multidimensional measure of child and adolescent behavior, affect, and cognitive ability and can be completed by parents. The overall goal of this project was to evaluate the psychometric characteristics of the PIC as a screening device for use with preschool populations. The…

  6. The serine protease Pic as a virulence factor of atypical enteropathogenic Escherichia coli.

    Science.gov (United States)

    Abreu, Afonso G; Abe, Cecilia M; Nunes, Kamila O; Moraes, Claudia T P; Chavez-Dueñas, Lucia; Navarro-Garcia, Fernando; Barbosa, Angela S; Piazza, Roxane M F; Elias, Waldir P

    2016-01-01

    Autotransporter proteins (AT) are associated with bacterial virulence attributes. Originally identified in enteroaggregative Escherichia coli (EAEC), Shigella flexneri 2a and uropathogenic E. coli, the serine protease Pic is one of these AT. We have previously detected one atypical enteropathogenic E. coli strain (BA589) carrying the pic gene. In the present study, we characterized the biological activities of Pic produced by BA589 both in vitro and in vivo. Contrarily to other Pic-producers bacteria, pic in BA589 is located on a high molecular weight plasmid. PicBA589 was able to agglutinate rabbit erythrocytes, cleave mucin and degrade complement system molecules. BA589 was able to colonize mice intestines, and an intense mucus production was observed. The BA589Δpic mutant lost the capacity to colonize as well as the above-mentioned in vitro activities. Thus, Pic represents an additional virulence factor in aEPEC strain BA589, associated with adherence, colonization and evasion from the innate immune system.

  7. Evaluation of Age, Sex, and Race Bias in the Personality Inventory for Children (PIC).

    Science.gov (United States)

    Kline, Rex B.; Lachar, David

    1992-01-01

    Whether the external validity of the Personality Inventory for Children (PIC) was moderated by age, sex, or race was studied using 1,333 children and adolescents referred for mental health services. Race and sex generally did not moderate the relation of PIC scales to symptom checklists. Some relationships were age modified. (SLD)

  8. Assessment of PIC and MMPI Scales in Adolescent Psychosis: A Caution.

    Science.gov (United States)

    Davies, Allison; And Others

    1987-01-01

    Investigated sensitivity of Personality Inventory for Children (PIC) and Minnesota Multiphasic Personality Inventory (MMPI) in assessing psychotic states in adolescents. Results from comparison of 29 psychotic and 58 nonpsychotic adolescent psychiatric inpatients suggest the need for a profile-analytic approach to PIC and MMPI interpretation in…

  9. A portable platform for accelerated PIC codes and its application to GPUs using OpenACC

    CERN Document Server

    Hariri, F; Jocksch, A; Lanti, E; Progsch, J; Messmer, P; Brunner, S; Gheller, G; Villard, L

    2016-01-01

    We present a portable platform, called PIC_ENGINE, for accelerating Particle-In-Cell (PIC) codes on heterogeneous many-core architectures such as Graphic Processing Units (GPUs). The aim of this development is efficient simulations on future exascale systems by allowing different parallelization strategies depending on the application problem and the specific architecture. To this end, this platform contains the basic steps of the PIC algorithm and has been designed as a test bed for different algorithmic options and data structures. Among the architectures that this engine can explore, particular attention is given here to systems equipped with GPUs. The study demonstrates that our portable PIC implementation based on the OpenACC programming model can achieve performance closely matching theoretical predictions. Using the Cray XC30 system, Piz Daint, at the Swiss National Supercomputing Centre (CSCS), we show that PIC_ENGINE running on an NVIDIA Kepler K20X GPU can outperform the one on an Intel Sandybridge ...

  10. PIC simulations of wave-mode conversion on the plasmapause

    Science.gov (United States)

    Horký, Miroslav; Omura, Yoshiharu; Santolík, Ondřej

    2017-04-01

    We study a conversion process from the electron Bernstein modes to electromagnetic free space modes using a 2D-3V electromagnetic PIC code with predefined particle density irregularities. We use a Gaussian profile of the particle density irregularity along the external magnetic field. Our results show the electron Bernstein modes generated by the ring-beam instability in the dense plasma region as well as their conversion into the electromagnetic waves. The resulting free space mode waves propagate out of the dense region perpendicular to magnetic field with the corresponding energy flux. Our simulation results are compared with measured data from Cluster and Van Allen Probes spacecraft. This wave mode conversion process might help us to explain generation of electromagnetic waves over the plasmapause density gradient.

  11. Non-linear PIC simulation in a penning trap

    Energy Technology Data Exchange (ETDEWEB)

    Delzanno, G. L. (Gian L.); Lapenta, G. M. (Giovanni M.); Finn, J. M. (John M.)

    2001-01-01

    We study the non-linear dynamics of a Penning trap plasma, including the effect of the finite length and end curvature of the plasma column. A new cylindrical PIC code, called KANDINSKY, has been implemented by using a new interpolation scheme. The principal idea is to calculate the volume of each cell from a particle volume, in the same manner as it is done for the cell charge. With this new method, the density is conserved along streamlines and artificial sources of compressibility are avoided. The code has been validated with a reference Eulerian fluid code. We compare the dynamics of three different models: a model with compression effects, the standard Euler model and a geophysical fluid dynamics model. The results of our investigation prove that Penning traps can really be used to simulate geophysical fluids.

  12. Modeling of Ionization Physics with the PIC Code OSIRIS

    Energy Technology Data Exchange (ETDEWEB)

    Deng, S.; Tsung, F.; Lee, S.; Lu, W.; Mori, W.B.; Katsouleas, T.; Muggli, P.; Blue, B.E.; Clayton, C.E.; O' Connell, C.; Dodd, E.; Decker, F.J.; Huang, C.; Hogan, M.J.; Hemker, R.; Iverson, R.H.; Joshi, C.; Ren, C.; Raimondi, P.; Wang, S.; Walz, D.; /Southern California U. /UCLA /SLAC

    2005-09-27

    When considering intense particle or laser beams propagating in dense plasma or gas, ionization plays an important role. Impact ionization and tunnel ionization may create new plasma electrons, altering the physics of wakefield accelerators, causing blue shifts in laser spectra, creating and modifying instabilities, etc. Here we describe the addition of an impact ionization package into the 3-D, object-oriented, fully parallel PIC code OSIRIS. We apply the simulation tool to simulate the parameters of the upcoming E164 Plasma Wakefield Accelerator experiment at the Stanford Linear Accelerator Center (SLAC). We find that impact ionization is dominated by the plasma electrons moving in the wake rather than the 30 GeV drive beam electrons. Impact ionization leads to a significant number of trapped electrons accelerated from rest in the wake.

  13. Octree particle management for DSMC and PIC simulations

    Science.gov (United States)

    Martin, Robert Scott; Cambier, Jean-Luc

    2016-12-01

    The ratio of physical to computationally modeled particles is of critical importance to the fidelity of particle-based simulation methods such as Direct Simulation Monte Carlo (DSMC) and Particle-in-Cell (PIC). Like adaptive mesh refinement for continuum/grid-based simulations, particle remapping enables dynamic control of simulation fidelity in regions of interest so that computational resources can be efficiently distributed within the problem. This is particularly important for simulations involving high dynamic range in the density for one or more species such as problems involving chain-branching reactions like combustion and ionizing breakdown. In this work, a new method of particle remapping is presented which strictly conserves mass, momentum, and energy while simultaneously remaining faithful to the original velocity distribution function through the use of octree binning in velocity space.

  14. PIC simulation of electron acceleration in an underdense plasma

    Directory of Open Access Journals (Sweden)

    S Darvish Molla

    2011-06-01

    Full Text Available One of the interesting Laser-Plasma phenomena, when the laser power is high and ultra intense, is the generation of large amplitude plasma waves (Wakefield and electron acceleration. An intense electromagnetic laser pulse can create plasma oscillations through the action of the nonlinear pondermotive force. electrons trapped in the wake can be accelerated to high energies, more than 1 TW. Of the wide variety of methods for generating a regular electric field in plasmas with strong laser radiation, the most attractive one at the present time is the scheme of the Laser Wake Field Accelerator (LWFA. In this method, a strong Langmuir wave is excited in the plasma. In such a wave, electrons are trapped and can acquire relativistic energies, accelerated to high energies. In this paper the PIC simulation of wakefield generation and electron acceleration in an underdense plasma with a short ultra intense laser pulse is discussed. 2D electromagnetic PIC code is written by FORTRAN 90, are developed, and the propagation of different electromagnetic waves in vacuum and plasma is shown. Next, the accuracy of implementation of 2D electromagnetic code is verified, making it relativistic and simulating the generating of wakefield and electron acceleration in an underdense plasma. It is shown that when a symmetric electromagnetic pulse passes through the plasma, the longitudinal field generated in plasma, at the back of the pulse, is weaker than the one due to an asymmetric electromagnetic pulse, and thus the electrons acquire less energy. About the asymmetric pulse, when front part of the pulse has smaller time rise than the back part of the pulse, a stronger wakefield generates, in plasma, at the back of the pulse, and consequently the electrons acquire more energy. In an inverse case, when the rise time of the back part of the pulse is bigger in comparison with that of the back part, a weaker wakefield generates and this leads to the fact that the electrons

  15. Parallel pic plasma simulation through particle decomposition techniques

    Energy Technology Data Exchange (ETDEWEB)

    Briguglio, S.; Vlad, G. [ENEA, Centro Ricerche Casaccia, Rome (Italy). Dipt. Energia; Di Martino, B. [Wien Univ. (Austria). Inst. for Software Tecnology and Parallel Systems]|[Naples, Univ. `Federico II` (Italy). Dipt. di Informatica e Sistemistica

    1998-02-01

    Particle-in-cell (PIC) codes are among the major candidates to yield a satisfactory description of the detail of kinetic effects, such as the resonant wave-particle interaction, relevant in determining the transport mechanism in magnetically confined plasmas. A significant improvement of the simulation performance of such codes con be expected from parallelization, e.g., by distributing the particle population among several parallel processors. Parallelization of a hybrid magnetohydrodynamic-gyrokinetic code has been accomplished within the High Performance Fortran (HPF) framework, and tested on the IBM SP2 parallel system, using a `particle decomposition` technique. The adopted technique requires a moderate effort in porting the code in parallel form and results in intrinsic load balancing and modest inter processor communication. The performance tests obtained confirm the hypothesis of high effectiveness of the strategy, if targeted towards moderately parallel architectures. Optimal use of resources is also discussed with reference to a specific physics problem. [Italiano] I codici Particle-in-cell (PIC) sono considerati tra i piu` promettenti candidati per ottenere una descrizione soddisfacente e dettagliata degli effetti cinetici, quali per esempio l`interazione risonante particella-onda, rilevanti nel determinare i meccanismi di trasporto che interessano il confinamento del plasma. Un significativo miglioramento delle prestazioni della simulazione puo` essere ottenuto distribuendo la popolazione di particelle tra diversi processori in parallelo. La parallelizzazione di un codice ibrido MHD-girocinetico e` stata effettuata, in ambiente HPF, utilizzando la tecnica di `decomposizione per particelle`, ed e` stata provata sul sistema parallelo IBM SP2. La tecnica adottata richiede uno sforzo moderato per la trasformazione del codice in versione parallela, permette un intrinseco bilanciamento tra i processori del carico di lavoro e necessita di una modesta

  16. Velocity control in three-phase induction motors using PIC; Controle de velocidade de motor de inducao trifasico usando PIC

    Energy Technology Data Exchange (ETDEWEB)

    Marcelino, M.A.; Silva, G.B.S.; Grandinetti, F.J. [Universidade Estadual Paulista (UNESP), Guaratingueta, SP (Brazil). Fac. de Engenharia; Universidade de Taubate (UNITAU), SP (Brazil)], Emails: abud@feg.unesp.br, gabonini@yahoo.com.br, grandinetti@unitau.br

    2009-07-01

    This paper presents a technique for speed control three-phase induction motor using the pulse width modulation (PWM), in open loop while maintaining the tension for constant frequency. The technique is adapted from a thesis entitled 'Control of the three-phase induction motor, using discrete PWM generation, optimized and synchronized', where studies are presented aimed at their application in home appliances, to eliminate mechanical parts, replaced by low cost electronic control, thus having a significant reduction in power consumption. Initially the experiment was done with the Intel 80C31 micro controller. In this paper, the PWM modulation is implemented using a PIC micro controller, and the speed control kept a low profile, based on tables, synchronized with transitions and reduced generation of harmonics in the network. Confirmations were made using the same process of building tables, but takes advantage of the program of a RISC device.

  17. 46 CFR 13.305 - Proof of service for “Tankerman-PIC (Barge)” endorsement.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Proof of service for âTankerman-PIC (Barge)â endorsement... AND SEAMEN CERTIFICATION OF TANKERMEN Requirements for âTankerman-PIC (Barge)â Endorsement § 13.305 Proof of service for “Tankerman-PIC (Barge)” endorsement. Service must be proved by a letter on...

  18. The Bayesian image retrieval system, PicHunter: theory, implementation, and psychophysical experiments.

    Science.gov (United States)

    Cox, I J; Miller, M L; Minka, T P; Papathomas, T V; Yianilos, P N

    2000-01-01

    This paper presents the theory, design principles, implementation and performance results of PicHunter, a prototype content-based image retrieval (CBIR) system. In addition, this document presents the rationale, design and results of psychophysical experiments that were conducted to address some key issues that arose during PicHunter's development. The PicHunter project makes four primary contributions to research on CBIR. First, PicHunter represents a simple instance of a general Bayesian framework which we describe for using relevance feedback to direct a search. With an explicit model of what users would do, given the target image they want, PicHunter uses Bayes's rule to predict the target they want, given their actions. This is done via a probability distribution over possible image targets, rather than by refining a query. Second, an entropy-minimizing display algorithm is described that attempts to maximize the information obtained from a user at each iteration of the search. Third, PicHunter makes use of hidden annotation rather than a possibly inaccurate/inconsistent annotation structure that the user must learn and make queries in. Finally, PicHunter introduces two experimental paradigms to quantitatively evaluate the performance of the system, and psychophysical experiments are presented that support the theoretical claims.

  19. 基于PIC18F4550的全速USB接口设计

    Institute of Scientific and Technical Information of China (English)

    黄超军; 李亚楠

    2012-01-01

      介绍了PIC18F4550单片机的特点和功能;给出基于PIC18F4550全速USB接口的压力计系统及电路设计;重点介绍了基于PIC4550主控方式的USB通讯接口设计、USB通讯流程、相应的USB固件程序和USB在线编程。

  20. Taxonomy of Fissocantharis Pic (Coleoptera, Cantharidae) from Guangxi, China, with descriptions of six new species.

    Science.gov (United States)

    Yang, Yuxia; Li, Limei; Guan, Kaile; Yang, Xingke

    2015-01-01

    A total of 17 species of Fissocantharis Pic is recorded from Guangxi, China. Six species are described new to science, Fissocantharissinensomima sp. n., Fissocantharissexcostata sp. n., Fissocantharisbasilaris sp. n., Fissocanthariseschara sp. n., Fissocantharislatipalpa sp. n. and Fissocantharisbiprojicientis sp. n., and two previously known species are redescribed, Fissocantharisgracilipes (Pic, 1927) and Fissocantharissinensis (Wittmer, 1988). These species are presented with habitus of males, abdominal sternites VIII of females and genitalia of both sexes. Fissocantharisflavofacialis (Pic, 1926) is synonymized with Fissocantharisangusta (Fairmaire, 1900); both were originally described in the genus Podabrus Westwood. Additionally, a key and a checklist of all the species of Fissocantharis from Guangxi are provided.

  1. Electron dynamics in collisionless magnetic reconnection with a PIC simulation

    Institute of Scientific and Technical Information of China (English)

    GUO Jun

    2009-01-01

    Two-dimensional particle-in-cell (PIC) simulation is used to investigate electron dynamics in colli-sionless magnetic reconnection, and the proton/electron mass ratio is taken to be ml/me = 256. The results show that the presence of a strong initial guide field will change the direction of the electron flow. The electron density cavities and the parallel electric field can be found in the electron inflow re-gion along the separatrix, and the electron inflow and density cavities only appear in the second and fourth quadrants. What is different from the results with a smaller mass ratio is that new structures appear in the diffusion region near the X line: (1) Narrow regions of density enhancement and density cavities can be found synchronously in this region; and (2) corresponding to the electron density changes near the X line, the strong parallel electric fields are found to occur in the first and third quadrants. These electric fields perhaps play a more important role in acceleration and heating elec-trons than those fields located in the density cavities.

  2. Onset of Reconnection in the near Magnetotail: PIC Simulations

    Science.gov (United States)

    Liu, Yi-Hsin; Birn, Joachim; Daughton, William; Hesse, Michael; Schindler, Karl

    2014-01-01

    Using 2.5-dimensional particle-in-cell (PIC) simulations of magnetotail dynamics, we investigate the onset of reconnection in two-dimensional tail configurations with finite Bz. Reconnection onset is preceded by a driven phase, during which magnetic flux is added to the tail at the high-latitude boundaries, followed by a relaxation phase, during which the configuration continues to respond to the driving. We found a clear distinction between stable and unstable cases, dependent on deformation amplitude and ion/electron mass ratio. The threshold appears consistent with electron tearing. The evolution prior to onset, as well as the evolution of stable cases, are largely independent of the mass ratio, governed by integral flux tube entropy conservation as imposed in MHD (magnetohydrodynamics). This suggests that ballooning instability in the tail should not be expected prior to the onset of tearing and reconnection. The onset time and other onset properties depend on the mass ratio, consistent with expectations for electron tearing. At onset,we found electron anisotropies T?/ T? (bottom tail divided by parallel tail) equals 1.1-1.3, raising growth rates and wavenumbers. Our simulations have provided a quantitative onset criterion that is easily evaluated in MHD simulations, provided the spatial resolution is sufficient. The evolution prior to onset and after the formation of a neutral line does not depend on the electron physics, which should permit an approximation by MHD simulations with appropriate dissipation terms.

  3. A PIC Based Code for Studying Space Charge Effects in Spiral Inflector

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>1 Modeling and code developing In this work we developed a new iterative numerical model based on the conventional PIC methods for modeling intense particle transport in inflector. Fig. 1 is the flow diagram of the iterative algorithm.

  4. Modulador-demodulador ASK con codificacion Manchester implementado en un microcontrolador PIC

    National Research Council Canada - National Science Library

    Tarifa Amaya, Ariel; Del Risco Sanchez, Arnaldo; Carlos Cruz Hurtado, Juan

    2012-01-01

    Se presenta el diseno de un Modulador-Demodulador Digital ASK con codificacion Manchester implementado en el firmware de un microcontrolador PIC 18F4455, utilizando el estandar de baja frecuencia (LF...

  5. A new species of the genus Falsoibidion Pic (Coleoptera, Cerambycidae) from Korea.

    Science.gov (United States)

    Lee, Seunghyun; Lee, Seunghwan

    2016-01-01

    A new species of the genus Falsoibidion Pic, 1922 (Coleoptera, Cerambycidae, Cerambycinae, Callidiopini) from Korea is described. Habitus and genitalia of male and female of the new species are illustrated.

  6. The PICS Climate Insights 101 Courses: A Visual Approach to Learning About Climate Science, Mitigation and Adaptation

    Science.gov (United States)

    Pedersen, T. F.; Zwiers, F. W.; Breen, C.; Murdock, T. Q.

    2014-12-01

    The Pacific Institute for Climate Solutions (PICS) has now made available online three free, peer-reviewed, unique animated short courses in a series entitled "Climate Insights 101" that respectively address basic climate science, carbon-emissions mitigation approaches and opportunities, and adaptation. The courses are suitable for students of all ages, and use professionally narrated animations designed to hold a viewer's attention. Multiple issues are covered, including complex concerns like the construction of general circulation models, carbon pricing schemes in various countries, and adaptation approaches in the face of extreme weather events. Clips will be shown in the presentation. The first course (Climate Science Basics) has now been seen by over two hundred thousand individuals in over 80 countries, despite being offered in English only. Each course takes about two hours to work through, and in recognizing that that duration might pose an attention barrier to some students, PICS selected a number of short clips from the climate-science course and posted them as independent snippets on YouTube. A companion series of YouTube videos entitled, "Clear The Air", was created to confront the major global-warming denier myths. But a major challenge remains: despite numerous efforts to promote the availability of the free courses and the shorter YouTube pieces, they have yet to become widely known. Strategies to overcome that constraint will be discussed.

  7. Photonic Integrated Circuit (PIC) Device Structures: Background, Fabrication Ecosystem, Relevance to Space Systems Applications, and Discussion of Related Radiation Effects

    Science.gov (United States)

    Alt, Shannon

    2016-01-01

    Electronic integrated circuits are considered one of the most significant technological advances of the 20th century, with demonstrated impact in their ability to incorporate successively higher numbers transistors and construct electronic devices onto a single CMOS chip. Photonic integrated circuits (PICs) exist as the optical analog to integrated circuits; however, in place of transistors, PICs consist of numerous scaled optical components, including such "building-block" structures as waveguides, MMIs, lasers, and optical ring resonators. The ability to construct electronic and photonic components on a single microsystems platform offers transformative potential for the development of technologies in fields including communications, biomedical device development, autonomous navigation, and chemical and atmospheric sensing. Developing on-chip systems that provide new avenues for integration and replacement of bulk optical and electro-optic components also reduces size, weight, power and cost (SWaP-C) limitations, which are important in the selection of instrumentation for specific flight projects. The number of applications currently emerging for complex photonics systems-particularly in data communications-warrants additional investigations when considering reliability for space systems development. This Body of Knowledge document seeks to provide an overview of existing integrated photonics architectures; the current state of design, development, and fabrication ecosystems in the United States and Europe; and potential space applications, with emphasis given to associated radiation effects and reliability.

  8. Implementación de un microcontrolador PIC con el método Grafcet

    OpenAIRE

    Arbeláez Salazar, Osiel; Mendoza Vargas, Jairo Alberto; Muriel Escobar, José Agustín

    2008-01-01

    Se describe una metodología para programar un microcontrolador PIC 16F84 a partir del Grafcet y se realiza una aplicación práctica de esta metodología a un problema en particular A methodology is described to program a microcontroler PIC 16F84, starting from the Grafcet of the solution of the problem and is carried out a practical application from this methodology to a particular problem

  9. Interfacing Of PIC 18F252 Microcontroller with Real Time Clock via I2C Protocol

    Directory of Open Access Journals (Sweden)

    Arnab G. Samanta

    2014-09-01

    Full Text Available This paper describes a microcontroller based digital clock which can be used in real time systems. The system is constructed using PIC18F252 (microcontroller, DS1307 (real time clock IC and its software program is written with C programming language. A 3v battery backup is provided to real time clock IC. Communication between PIC microcontroller and DS1307 takes place through I²C Bus protocol.

  10. Design And Construction Of Digital Multi-Meter Using PIC Microcontroller

    OpenAIRE

    Khawn Nue; Dr. KyawSoe Lwin; Hla Myo Tun

    2015-01-01

    Abstract This thesis describes the design and construction of digital multi-meter using PIC microcontroller. In this system a typical multi-meter may include features such as the ability to measure ACDC voltage DC current resistance temperature diodes frequency and connectivity. This design uses of the PIC microcontroller voltage rectifiers voltage divide potentiometer LCD and other instruments to complete the measure. When we used what we have learned of microprocessors and adjust the progra...

  11. Dynamic Particle Weight Remapping in Hybrid PIC Hall-effect Thruster Simulation

    Science.gov (United States)

    2015-05-01

    International Electric Propulsion Conference and 6th Nano-satellite Symposium Hyogo-Kobe, Japan July 410, 2015 Robert Martin∗ ERC Incorporated, Huntsville...Algorithms, . 8Koo, J. and Martin, R., Pseudospectral model for hybrid PIC Hall -eect thruster simulation, 34th Int. Electric Propul- sion Conf...Paper 3. DATES COVERED (From - To) May 2015-July 2015 4. TITLE AND SUBTITLE Dynamic Particle Weight Remapping in Hybrid PIC Hall -effect Thruster

  12. Ping-pong effects study in PIC turbo joint detection for TDD CDMA

    Institute of Scientific and Technical Information of China (English)

    Song Changjian; Zhong Zifa; Zhang Shuo

    2009-01-01

    A kind of turbo joint detection scheme based on parallel interference cancellation (PIC) is studied; then, the eigenvalues of iteration matrix is deeply analyzed for studying the ping-pong effects in PIC JD and the corresponding compensation approach is introduced. Finally, the proposed algorithm is validated through computer simulation in TDD CDMA uplink transmission. The result shows that the ping-pong effects are almost avoided completely in the presence of the compensation scheme, and system performance is greatly improved.

  13. Soubor úloh postavených na jednočipech PIC

    OpenAIRE

    BOHÁČ, Zdeněk

    2009-01-01

    This work contains collection of problems with the microcontrollers PIC. The work first shortly acquaint with used hardware, whereby is microprocessor PIC16F84A. This microcontroller is very good for education of programming for students on secondary school. This work have to help with study in programming microcontrollers on the secondary school. Next chapters contains manuals for programming in low-level language assembler and for language higher level - C language plus manuals for developm...

  14. The genus Dromanthomorphus Pic, 1921 (Coleoptera, Cleroidea: Malachiidae) in South-East Asia.

    Science.gov (United States)

    Tshernyshev, Sergei E

    2016-07-22

    South-East Asian species of the genus Dromanthomorphus Pic, 1921 and several species provisionally attributed to Hadrocnemus Kraatz, 1895 are studied, and their taxonomic position is specified. Three new species are described from the Philippines: D. subflabellatus Tshernyshev, sp. n., D. restrictus Tshernyshev, sp. n. and D. subtilis Tshernyshev, sp. n. Seven species are transferred from Hadrocnemus to Dromanthomorphus, D. apoensis (Wittmer, 1999) comb. n., D. blaisei (Pic, 1926) comb. n., D. chiangensis (Wittmer, 1999) comb. n., D. depressicornis (Pic, 1919) comb. n., D. gravieri (Pic, 1923) comb. n., D. javanus (Wittmer, 1989) comb. n. and D. tonkineus (Pic, 1919) comb. n. Three species are transferred from Dromanthomorphus to Oculapalochrus Tshernyshev, 2015, O. ranuensis Wittmer 1990 comb. n., O. saigonensis (Pic, 1951) comb. n. and O. suttoni Wittmer, 1995 comb. n., and two species from Dromanthomorphus to Mimapalochrus Tshernyshev, 2015, M. cingalensis (Champion, 1921) comb. n. and M. dolokensis Wittmer, 1999 comb. n. Illustrations of male external appearance, metathoracic appendage, urites and genitalia, and distribution maps are provided. A determination key to all species of Dromanthomorphus from South-East Asia is also proposed.

  15. PIC Simulations of mini-magnetospheres above the lunar surface and the formation of Lunar Swirls

    Science.gov (United States)

    Bamford, R. A.; Alves, E. P.; Kellett, B.; Bradford, W. J.; Silva, L.; Crawford, I. A.; Trines, R. M. G. M.; Fonseca, R. A.; Gargate, L.; Bingham, R.

    2013-09-01

    small scale regime below the ion gyro radius (which is generally ›› 100km), the plasma has to be treated by kinetic theory and a particle-in-a-cell (PIC) code is necessary to model the complex dynamics taking place between the solar wind and the crustal magnetic fields. We will describe results of PIC simulations and compare them to in-situ observations from multiple lunar missions as well as laboratory experiments.

  16. Spatial resolution of a {\\mu}PIC-based neutron imaging detector

    CERN Document Server

    Parker, Joseph D; Hattori, Kaori; Iwaki, Satoru; Kabuki, Shigeto; Kishimoto, Yuji; Kubo, Hidetoshi; Kurosawa, Shunsuke; Matsuoka, Yoshihiro; Miuchi, Kentaro; Mizumoto, Tetsuya; Nishimura, Hironobu; Oku, Takayuki; Sawano, Tatsuya; Shinohara, Takenao; Suzuki, Jun-ichi; Takada, Atsushi; Tanimori, Toru; Ueno, Kazuki

    2013-01-01

    We present a detailed study of the spatial resolution of our time-resolved neutron imaging detector utilizing a new neutron position reconstruction method that improves both spatial resolution and event reconstruction efficiency. Our prototype detector system, employing a micro-pattern gaseous detector known as the micro-pixel chamber ({\\mu}PIC) coupled with a field-programmable-gate-array-based data acquisition system, combines 100{\\mu}m-level spatial and sub-{\\mu}s time resolutions with excellent gamma rejection and high data rates, making it well suited for applications in neutron radiography at high-intensity, pulsed neutron sources. From data taken at the Materials and Life Science Experimental Facility within the Japan Proton Accelerator Research Complex (J-PARC), the spatial resolution was found to be approximately Gaussian with a sigma of 103.48 +/- 0.77 {\\mu}m (after correcting for beam divergence). This is a significant improvement over that achievable with our previous reconstruction method (334 +/...

  17. PIC Simulation of RF Plasma Sheath Formation and Initial Validation of Optical Diagnostics using HPC Resources

    Science.gov (United States)

    Icenhour, Casey; Exum, Ashe; Martin, Elijah; Green, David; Smithe, David; Shannon, Steven

    2014-10-01

    The coupling of experiment and simulation to elucidate near field physics above ICRF antennae presents challenges on both the experimental and computational side. In order to analyze this region, a new optical diagnostic utilizing active and passive spectroscopy is used to determine the structure of the electric fields within the sheath region. Parallel and perpendicular magnetic fields with respect to the sheath electric field have been presented. This work focuses on the validation of these measurements utilizing the Particle-in-Cell (PIC) simulation method in conjunction with High Performance Computing (HPC) resources on the Titan supercomputer at Oak Ridge National Laboratory (ORNL). Plasma parameters of interest include electron density, electron temperature, plasma potentials, and RF plasma sheath voltages and thicknesses. The plasma is modeled utilizing the VSim plasma simulation tool, developed by the Tech-X Corporation. The implementation used here is a two-dimensional electromagnetic model of the experimental setup. The overall goal of this study is to develop models for complex RF plasma systems and to help outline the physics of RF sheath formation and subsequent power loss on ICRF antennas in systems such as ITER. This work is carried out with the support of Oak Ridge National Laboratory and the Tech-X Corporation.

  18. Low-temperature plasma simulations with the LSP PIC code

    Science.gov (United States)

    Carlsson, Johan; Khrabrov, Alex; Kaganovich, Igor; Keating, David; Selezneva, Svetlana; Sommerer, Timothy

    2014-10-01

    The LSP (Large-Scale Plasma) PIC-MCC code has been used to simulate several low-temperature plasma configurations, including a gas switch for high-power AC/DC conversion, a glow discharge and a Hall thruster. Simulation results will be presented with an emphasis on code comparison and validation against experiment. High-voltage, direct-current (HVDC) power transmission is becoming more common as it can reduce construction costs and power losses. Solid-state power-electronics devices are presently used, but it has been proposed that gas switches could become a compact, less costly, alternative. A gas-switch conversion device would be based on a glow discharge, with a magnetically insulated cold cathode. Its operation is similar to that of a sputtering magnetron, but with much higher pressure (0.1 to 0.3 Torr) in order to achieve high current density. We have performed 1D (axial) and 2D (axial/radial) simulations of such a gas switch using LSP. The 1D results were compared with results from the EDIPIC code. To test and compare the collision models used by the LSP and EDIPIC codes in more detail, a validation exercise was performed for the cathode fall of a glow discharge. We will also present some 2D (radial/azimuthal) LSP simulations of a Hall thruster. The information, data, or work presented herein was funded in part by the Advanced Research Projects Agency-Energy (ARPA-E), U.S. Department of Energy, under Award Number DE-AR0000298.

  19. A portable approach for PIC on emerging architectures

    Science.gov (United States)

    Decyk, Viktor

    2016-03-01

    A portable approach for designing Particle-in-Cell (PIC) algorithms on emerging exascale computers, is based on the recognition that 3 distinct programming paradigms are needed. They are: low level vector (SIMD) processing, middle level shared memory parallel programing, and high level distributed memory programming. In addition, there is a memory hierarchy associated with each level. Such algorithms can be initially developed using vectorizing compilers, OpenMP, and MPI. This is the approach recommended by Intel for the Phi processor. These algorithms can then be translated and possibly specialized to other programming models and languages, as needed. For example, the vector processing and shared memory programming might be done with CUDA instead of vectorizing compilers and OpenMP, but generally the algorithm itself is not greatly changed. The UCLA PICKSC web site at http://www.idre.ucla.edu/ contains example open source skeleton codes (mini-apps) illustrating each of these three programming models, individually and in combination. Fortran2003 now supports abstract data types, and design patterns can be used to support a variety of implementations within the same code base. Fortran2003 also supports interoperability with C so that implementations in C languages are also easy to use. Finally, main codes can be translated into dynamic environments such as Python, while still taking advantage of high performing compiled languages. Parallel languages are still evolving with interesting developments in co-Array Fortran, UPC, and OpenACC, among others, and these can also be supported within the same software architecture. Work supported by NSF and DOE Grants.

  20. Response of plasma facing components in Tokamaks due to intense energy deposition using Particle-In-Cell (PIC) methods

    Science.gov (United States)

    Genco, Filippo

    complex dynamics problems involving distorted plasma hydrodynamic problems and plasma physics. The PIC method solves the hydrodynamic equations solving all field equations tracking at the same time "sample particles" or pseudo-particles (representative of the much more numerous real ones) as the move under the influence of diffusion or magnetic force. The superior behavior of the PIC techniques over the more classical Lagrangian finite difference methods stands in the fact that detailed information about the particles are available at all times as well as mass and momentum transport values are constantly provided. This allows with a relative small number of particles to well describe the behavior of plasma even in presence of highly distorted flows without losing accuracy. The radiation transport equation is solved at each time step calculating for each cell the opacity and emissivity coefficients. Photon radiation continuum and line fluxes are also calculated per the entire domain and provide useful information for the entire energetic calculation of the system which in the end provides the total values of erosion and lifetime of the target material. In this thesis, a new code named HEIGHTS-PIC code has been created and modified using a new approach of the PIC technique to solve the three physics problems involved integrating each of them as a continuum providing insight on the plasma behavior, evolution along time and physical understanding of the very complex phenomena taking place. The results produced with the models are compared with the well-known and benchmarked HEIGHTS package and also with existing experimental results especially produced in Russia at the TRINITI facility. Comparisons with LASER experiments are also discussed.

  1. Design of RKE system based on PIC16 F877 controller%基于PIC16F877A控制器的RKE系统的设计

    Institute of Scientific and Technical Information of China (English)

    王东; 刘琪; 郭兆正

    2014-01-01

    研究了一类基于PIC16F877A单片机控制器RKE控制系统问题,提出了系统的软硬件设计方法。采用了PIC16F877A、MAX1479/1471为核心器件,搭配相应的外围电路,设计一款基于ASK/OOK超外差射频的RKE控制系统。该系统具有外围电路简单、可靠性好、成本低等优点,因此它具有很好的市场推行价值。%Problems of a class of REK control system based on PIC16F877A were studied in the paper.The hardware and software design methods were proposed.The PIC16F877A, MAX1479/1471 were adopted as the core device in the system.With the corresponding peripheral circuits, the RKE control system of superheterodyne radio frequency based on ASK/baton was designed.The system has simple peripheral circuit, good reliability, low cost and good market value.

  2. Synthesis and Structural Characterization of Cu(pic)2[CO(NH2)2]2 and (picH2)2[Cu(pic)2(SCN)2

    Institute of Scientific and Technical Information of China (English)

    郭光华; 杨春; 周国伟; 郭国聪; 王明盛; 蔡丽珍; 吴阿青; 黄锦顺

    2004-01-01

    Two new compounds Cu(pic)2[CO(NH2)2]2 1 and (picH2)2[Cu(pic)2(SCN)2] 2 were prepared from the reaction of picolinic acid and copper(Ⅱ) per-chlorate by using carbamide to adjust pH=4 in the preparation of compound 1 and KSCN to adjust pH=6 in the preparation of 2. Crystal data for 1: monoclinic system, space group P21/n with a=7.441(1), b=14.291(2), c=7.790(1) A, β=95.855(2)°, V=824.0(2) A3, Dc=1.724 g/cm3, F(000)=438, C14H16N606Cu, Mr=427.87,μ(MoKα)=1.375 mm-1, Z=2 and the final R=0.0365 for 1164 observed reflections. Crystal data for 2: monoclinic system, space group P21/c with a=9.8237(3), b=10.0409(3), c=14.5867(2) A, β -= 104.190(2), V=1394.91(6) A3, Dc= 1.595 g/cm3, F(000)=686, C26H20N6O8S2Cu, Mr=672.14,μ(MoKα)=0.994 mm-1, Z=2 and the final R=0.0442 for .1651 observed reflections. The Cu(Ⅱ)atom in both 1 and 2 has a 4+2 elongated octahedral environment with the pic- ligands locating on the equatorial plane, and carbamide and SCN- occupying the axial sites, respectively. In compound 2,there also exist two protonated picolinate cations for charge balance.

  3. The PIC Cystogram: Its Place in the Treatment Algorithm of Recurrent Febrile UTIs

    Directory of Open Access Journals (Sweden)

    Jennifer A. Hagerty

    2008-01-01

    Full Text Available Purpose. A common pediatric dilemma involves management of children with recurrent febrile urinary tract infections (UTIs who have normal voiding cystourethrograms. Vesicoureteral reflux (VUR has been demonstrated in such cases by performing a cystogram which positions the instillation of contrast (PIC at the ureteral orifice. We describe the evidence supporting this diagnostic test. Materials and Methods. The literature was searched to identify and subsequently evaluate all studies investigating PIC cystography. Results. In patients with febrile UTIs and negative VCUGs, the PIC cystogram has been demonstrated to identify occult reflux (PIC-VUR. When identified and treated, these patients have a significant reduction in the incidence of febrile UTIs. Conclusions. Although the current literature on PIC cystography is limited, it appears to be a clinically useful test in a select group of patients with recurrent febrile UTIs, that are not found to have VUR on a conventional VCUG. A prospective randomized trial is underway to further define its role in the treatment algorithm of febrile UTIs.

  4. Construction of pPIC9 Recombinant Vector Containing Human Stem Cell Factor

    Directory of Open Access Journals (Sweden)

    Behrooz Farhadi

    2013-08-01

    Full Text Available Purpose: Various cytokine regulates hematopoesis; they promote number of stages in stem cells biology such as proliferation, differentiation and endurance. Biological effects of SCF, as a hematopoietic cytokine; is triggered by binding to its ligand c-kit. Potential therapeutic applications of SCF include hematopoietic stem cell mobilization, exvivo stem/progenitor cell expansion, gene therapy, and immunotherapy. In this study we tried to construct of pPIC9 recombinant vector containing human SCF. Methods: hSCF cDNA was amplified by PCR and both hSCF cDNA and pPIC9 as yeast expression vector (shuttle vector digested by EcoR I and Xho I restriction enzymes. Subsequent the digestion reaction, ligation reaction was carried out. In order to verifying of pPIC9 recombinant vector containing hSCF, PCR and sequence analysis was performed. Results: The construction of recombinant expression vector of pPIC9 containing hSCF cDNA was confirmed by sequencing method successfully. Conclusion: rhSCF/pPIC9 vector can be transformed into the Picha pastoris yeast as a eukaryotic host in order to produce human SCF at industrial scale.

  5. Appropriateness of the food-pics image database for experimental eating and appetite research with adolescents.

    Science.gov (United States)

    Jensen, Chad D; Duraccio, Kara M; Barnett, Kimberly A; Stevens, Kimberly S

    2016-12-01

    Research examining effects of visual food cues on appetite-related brain processes and eating behavior has proliferated. Recently investigators have developed food image databases for use across experimental studies examining appetite and eating behavior. The food-pics image database represents a standardized, freely available image library originally validated in a large sample primarily comprised of adults. The suitability of the images for use with adolescents has not been investigated. The aim of the present study was to evaluate the appropriateness of the food-pics image library for appetite and eating research with adolescents. Three hundred and seven adolescents (ages 12-17) provided ratings of recognizability, palatability, and desire to eat, for images from the food-pics database. Moreover, participants rated the caloric content (high vs. low) and healthiness (healthy vs. unhealthy) of each image. Adolescents rated approximately 75% of the food images as recognizable. Approximately 65% of recognizable images were correctly categorized as high vs. low calorie and 63% were correctly classified as healthy vs. unhealthy in 80% or more of image ratings. These results suggest that a smaller subset of the food-pics image database is appropriate for use with adolescents. With some modifications to included images, the food-pics image database appears to be appropriate for use in experimental appetite and eating-related research conducted with adolescents. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. A portable platform for accelerated PIC codes and its application to GPUs using OpenACC

    Science.gov (United States)

    Hariri, F.; Tran, T. M.; Jocksch, A.; Lanti, E.; Progsch, J.; Messmer, P.; Brunner, S.; Gheller, C.; Villard, L.

    2016-10-01

    We present a portable platform, called PIC_ENGINE, for accelerating Particle-In-Cell (PIC) codes on heterogeneous many-core architectures such as Graphic Processing Units (GPUs). The aim of this development is efficient simulations on future exascale systems by allowing different parallelization strategies depending on the application problem and the specific architecture. To this end, this platform contains the basic steps of the PIC algorithm and has been designed as a test bed for different algorithmic options and data structures. Among the architectures that this engine can explore, particular attention is given here to systems equipped with GPUs. The study demonstrates that our portable PIC implementation based on the OpenACC programming model can achieve performance closely matching theoretical predictions. Using the Cray XC30 system, Piz Daint, at the Swiss National Supercomputing Centre (CSCS), we show that PIC_ENGINE running on an NVIDIA Kepler K20X GPU can outperform the one on an Intel Sandy bridge 8-core CPU by a factor of 3.4.

  7. Forced Reconnection in the Near Magnetotail: Onset and Energy Conversion in PIC and MHD Simulations

    Science.gov (United States)

    Birn, J.; Hesse, Michael

    2014-01-01

    Using two-dimensional particle-in-cell (PIC) together with magnetohydrodynamic (MHD) Q1 simulations of magnetotail dynamics, we investigate the evolution toward onset of reconnection and the subsequent energy transfer and conversion. In either case, reconnection onset is preceded by a driven phase, during which magnetic flux is added to the tail at the high-latitude boundaries, followed by a relaxation phase, during which the configuration continues to respond to the driving. The boundary deformation leads to the formation of thin embedded current sheets, which are bifurcated in the near tail, converging to a single sheet farther out in the MHD simulations. The thin current sheets in the PIC simulation are carried by electrons and are associated with a strong perpendicular electrostatic field, which may provide a connection to parallel potentials and auroral arcs and an ionospheric signal even prior to the onset of reconnection. The PIC simulation very well satisfies integral entropy conservation (intrinsic to ideal MHD) during this phase, supporting ideal ballooning stability. Eventually, the current intensification leads to the onset of reconnection, the formation and ejection of a plasmoid, and a collapse of the inner tail. The earthward flow shows the characteristics of a dipolarization front: enhancement of Bz, associated with a thin vertical electron current sheet in the PIC simulation. Both MHD and PIC simulations show a dominance of energy conversion from incoming Poynting flux to outgoing enthalpy flux, resulting in heating of the inner tail. Localized Joule dissipation plays only a minor role.

  8. Percutaneous intragastric catheter (PIC) for administration of an unpalatable substance to large animals.

    Science.gov (United States)

    Oleszczuk, Agnieszka; Spannbauer, Michael M; Bluher, Matthias; Ott, Rudolf; Pietsch, Uta-Carolin; Schneider, Katja; Madaj-Sterba, Petra; Furll, Manfred; Hauss, Johann P; Schön, Michael R

    2009-01-01

    We studied an easy and reliable technique for administration of an unpalatable substance to large animals. There were three groups of pigs: group I (n = 6) received 1 g ethanol/kg body weight per day orally with water for 24 days, group II (n = 6) received 2 g ethanol/kg orally with water for 24 days and 4 g ethanol/kg via percutaneous intragastric catheter (PIC) for the next 24 days, group III (n = 6) received 6 g ethanol/kg via PIC for 72 days. The catheter was placed after insufflation of the stomach using an orogastric tube. PIC was successfully placed in each pig. No complications occurred during placement. The total amount of the administrated dose was assimilated each time. PIC is a safe, effective, well tolerated, and precise method of administering ethanol that is inexpensive and easy to perform. Ethanol administration via PIC is a convenient and effective mean of exposing animals to high levels of alcohol on a long-term basis.

  9. Pic, an autotransporter protein secreted by different pathogens in the Enterobacteriaceae family, is a potent mucus secretagogue.

    Science.gov (United States)

    Navarro-Garcia, Fernando; Gutierrez-Jimenez, Javier; Garcia-Tovar, Carlos; Castro, Luis A; Salazar-Gonzalez, Hector; Cordova, Vanessa

    2010-10-01

    A hallmark of enteroaggregative Escherichia coli (EAEC) infection is a formation of biofilm, which comprises a mucus layer with immersed bacteria in the intestines of patients. While studying the mucinolytic activity of Pic in an in vivo system, rat ileal loops, we surprisingly found that EAEC induced hypersecretion of mucus, which was accompanied by an increase in the number of mucus-containing goblet cells. Interestingly, an isogenic pic mutant (EAEC Δpic) was unable to cause this mucus hypersecretion. Furthermore, purified Pic was also able to induce intestinal mucus hypersecretion, and this effect was abolished when Pic was heat denatured. Site-directed mutagenesis of the serine protease catalytic residue of Pic showed that, unlike the mucinolytic activity, secretagogue activity did not depend on this catalytic serine protease motif. Other pathogens harboring the pic gene, such as Shigella flexneri and uropathogenic E. coli (UPEC), also showed results similar to those for EAEC, and construction of isogenic pic mutants of S. flexneri and UPEC confirmed this secretagogue activity. Thus, Pic mucinase is responsible for one of the pathophysiologic features of the diarrhea mediated by EAEC and the mucoid diarrhea induced by S. flexneri.

  10. pH/sugar dual responsive core-cross-linked PIC micelles for enhanced intracellular protein delivery.

    Science.gov (United States)

    Ren, Jie; Zhang, Yanxin; Zhang, Ju; Gao, Hongjun; Liu, Gan; Ma, Rujiang; An, Yingli; Kong, Deling; Shi, Linqi

    2013-10-14

    Herein, a series of biocompatible, robust, pH/sugar-sensitive, core-cross-linked, polyion complex (PIC) micelles based on phenylboronic acid-catechol interaction were developed for protein intracellular delivery. The rationally designed poly(ethylene glycol)-b-poly(glutamic acid-co-glutamicamidophenylboronic acid) (PEG-b-P(Glu-co-GluPBA)) and poly(ethylene glycol)-b-poly(l-lysine-co-ε-3,4-dihydroxyphenylcarboxyl-L-lysine) (PEG-b-P(Lys-co-LysCA)) copolymers were successfully synthesized and self-assembled under neutral aqueous condition to form uniform micelles. These micelles possessed a distinct core-cross-linked core-shell structure comprised of the PEG outer shell and the PGlu/PLys polyion complex core bearing boronate ester cross-linking bonds. The cross-linked micelles displayed superior physiological stabilities compared with their non-cross-linked counterparts while swelling and disassembling in the presence of excess fructose or at endosomal pH. Notably, either negatively or positively charged proteins can be encapsulated into the micelles efficiently under mild conditions. The in vitro release studies showed that the release of protein cargoes under physiological conditions was minimized, while a burst release occurred in response to excess fructose or endosomal pH. The cytotoxicity of micelles was determined by cck-8 assay in HepG2 cells. The cytochrome C loaded micelles could efficiently delivery proteins into HepG2 cells and exhibited enhanced apoptosis ability. Hence, this type of core-cross-linked PIC micelles has opened a new avenue to intracellular protein delivery.

  11. DESIGN OF SINGLE PHASE INVERTER USING dsPIC30F4013

    Directory of Open Access Journals (Sweden)

    R.Senthilkumar

    2010-11-01

    Full Text Available This paper gives the design and implementation of a single-phase inverter that produces a symmetric ac output voltage of desired magnitude and frequency. A diode bridge rectifier is used to rectify the ac line voltage. Unipolar PWM technique is employed to control the output voltage magnitude and frequency. The digital signal Peripheral Interface Controller (dsPIC dsPIC30F4013 of Microchip Technology is used for the implementation of the inverter. A DC to Ac voltage converter consists of four bidirectional switches that is used to convert the voltage. Sinusoidal unipolor Pulse Width Modulation is used for triggering the gates of IGBTs. The control circuit consists of the dsPIC controller and it is used to produce required SPWM for triggering the IGBTs.Tthe driver circuit isolates the control circuit from power circuit. The outputs for variable AC voltages are observed in the CRO.

  12. Saltwell PIC Skid Programmable Logic Controller (PLC) Software Configuration Management Plan

    Energy Technology Data Exchange (ETDEWEB)

    KOCH, M.R.

    1999-11-16

    This document provides the procedures and guidelines necessary for computer software configuration management activities during the operation and maintenance phases of the Saltwell PIC Skids as required by LMH-PRO-309, Rev. 0, Computer Software Quality Assurance, Section 2.6, Software Configuration Management. The software configuration management plan (SCMP) integrates technical and administrative controls to establish and maintain technical consistency among requirements, physical configuration, and documentation for the Saltwell PIC Skid Programmable Logic Controller (PLC) software during the Hanford application, operations and maintenance. This SCMP establishes the Saltwell PIC Skid PLC Software Baseline, status changes to that baseline, and ensures that software meets design and operational requirements and is tested in accordance with their design basis.

  13. The chloroplast permease PIC1 regulates plant growth and development by directing homeostasis and transport of iron.

    Science.gov (United States)

    Duy, Daniela; Stübe, Roland; Wanner, Gerhard; Philippar, Katrin

    2011-04-01

    The membrane-spanning protein PIC1 (for permease in chloroplasts 1) in Arabidopsis (Arabidopsis thaliana) was previously described to mediate iron transport across the inner envelope membrane of chloroplasts. The albino phenotype of pic1 knockout mutants was reminiscent of iron-deficiency symptoms and characterized by severely impaired plastid development and plant growth. In addition, plants lacking PIC1 showed a striking increase in chloroplast ferritin clusters, which function in protection from oxidative stress by sequestering highly reactive free iron in their spherical protein shell. In contrast, PIC1-overexpressing lines (PIC1ox) in this study rather resembled ferritin loss-of-function plants. PIC1ox plants suffered from oxidative stress and leaf chlorosis, most likely originating from iron overload in chloroplasts. Later during growth, plants were characterized by reduced biomass as well as severely defective flower and seed development. As a result of PIC1 protein increase in the inner envelope membrane of plastids, flower tissue showed elevated levels of iron, while the content of other transition metals (copper, zinc, manganese) remained unchanged. Seeds, however, specifically revealed iron deficiency, suggesting that PIC1 overexpression sequestered iron in flower plastids, thereby becoming unavailable for seed iron loading. In addition, expression of genes associated with metal transport and homeostasis as well as photosynthesis was deregulated in PIC1ox plants. Thus, PIC1 function in plastid iron transport is closely linked to ferritin and plastid iron homeostasis. In consequence, PIC1 is crucial for balancing plant iron metabolism in general, thereby regulating plant growth and in particular fruit development.

  14. Application Design of PIC18F4550 with Full Speed USB Interface%带全速USB接口的PIC18F4550应用设计

    Institute of Scientific and Technical Information of China (English)

    曹卫锋; 闫红岩; 文方

    2007-01-01

    介绍带全速USB接口的单片机PIC18F4550的特点,并利用它的USB接口设计了一个光栅位移检测装置.本设计提高了光栅位移检测系统的抗干扰能力和可靠性,减小了系统的体积,降低了系统的成本.

  15. 如何使PIC16Fxxx微控制器拥有8个计时器?%Use Eight Timers with PIC16Fxxx Microcontrollers

    Institute of Scientific and Technical Information of China (English)

    Luis G Uribe C

    2010-01-01

    @@ 在嵌入式编程领域,对计时的需求经常会超过微控制器中的可用硬件计时器的有限数量.例如,Microchip公司的PIC16F84A只有一个计时器,但你可以借助Timers8.inc汇编代码创造出8个计时器.

  16. Doubling-resolution analog-to-digital conversion based on PIC18F45K80

    Directory of Open Access Journals (Sweden)

    Yueyang Yuan

    2014-08-01

    Full Text Available Aiming at the analog signal being converted into the digital with a higher precision, a method to improve the analog-to-digital converter (ADC resolution is proposed and described. Based on the microcomputer PIC18F45K80 in which the internal ADC modules are embedded, a circuit is designed for doubling the resolution of ADC. According to the circuit diagram, the mathematical formula for calculating this resolution is derived. The corresponding software and print circuit board assembly is also prepared. With the experiment, a 13 bit ADC is achieved based on the 12 bit ADC module predesigned in the PIC18F45K80.

  17. GRB observed by IBIS/PICsIT in the MeV energy range

    Energy Technology Data Exchange (ETDEWEB)

    Bianchin, V.; Foschini, L.; Di Cocco, G.; Gianotti, F.; Malaguti, G.; Schiavone, F. [INAF, IASF Bologna, I-40129 Bologna, (Italy); Gotz, D.; Laurent, P. [CEA, IRFU, SAp, F-91191 Gif Sur Yvette, (France); Laurent, P. [APC, F-75205 Paris, (France)

    2009-07-01

    We present the preliminary results of a systematic search for GRB and other transients ill the publicly available data for the IBIS/PICsIT (0.2-10 MeV) detector on board INTEGRAL. Light curves in 2-8 energy bands with time resolution from 1 to 62.5 ms have been collected and an analysis of spectral and temporal characteristics has been performed. This is the nucleus of a forthcoming first catalog of GRB observed by PICsIT. (authors)

  18. Wireless Control of Vehicle Mirror System Using Head Movement and PIC Microcontroller

    Directory of Open Access Journals (Sweden)

    Nidal F. Shilbayeh

    2005-01-01

    Full Text Available A PIC controlled IR system for the control car mirror system movement is designed and implemented. The designed and built system allows the side view mirrors to be adjusted based on the driver head movement. The infrared based head tracking system maps a predetermined coordinates for head movements and results in a triangularly computable geometry which is fed to the PIC based controlling system. This will cause the vehicle mirror movement via carefully selected miniature motors. The system takes blind spots and their angles into consideration

  19. Complexity

    CERN Document Server

    Gershenson, Carlos

    2011-01-01

    The term complexity derives etymologically from the Latin plexus, which means interwoven. Intuitively, this implies that something complex is composed by elements that are difficult to separate. This difficulty arises from the relevant interactions that take place between components. This lack of separability is at odds with the classical scientific method - which has been used since the times of Galileo, Newton, Descartes, and Laplace - and has also influenced philosophy and engineering. In recent decades, the scientific study of complexity and complex systems has proposed a paradigm shift in science and philosophy, proposing novel methods that take into account relevant interactions.

  20. Inhibition of Myeloperoxidase Activity in Cystic Fibrosis Sputum by Peptide Inhibitor of Complement C1 (PIC1)

    Science.gov (United States)

    Hair, Pamela S.; Sass, Laura A.; Krishna, Neel K.

    2017-01-01

    Myeloperoxidase is the major peroxidase enzyme in neutrophil granules and implicated in contributing to inflammatory lung damage in cystic fibrosis. Free myeloperoxidase is present in cystic fibrosis lung fluid and generates hypochlorous acid. Here we report a new inhibitor of myeloperoxidase activity, Peptide Inhibitor of Complement C1 (PIC1). Using TMB as the oxidizing substrate, PIC1 inhibited myeloperoxidase activity in cystic fibrosis sputum soluble fractions by an average of a 3.4-fold decrease (P = 0.02). PIC1 also dose-dependently inhibited myeloperoxidase activity in a neutrophil lysate or purified myeloperoxidase by up to 28-fold (P < 0.001). PIC1 inhibited myeloperoxidase activity similarly, on a molar basis, as the specific myeloperoxidase inhibitor 4-Aminobenzoic acid hydrazide (ABAH) for various oxidizing substrates. PIC1 was able to protect the heme ring of myeloperoxidase from destruction by NaOCl, assayed by spectral analysis. PIC1 incubated with oxidized TMB reversed the oxidation state of TMB, as measured by absorbance at 450 nm, with a 20-fold reduction in oxidized TMB (P = 0.02). This result was consistent with an antioxidant mechanism for PIC1. In summary, PIC1 inhibits the peroxidase activity of myeloperoxidase in CF sputum likely via an antioxidant mechanism. PMID:28135312

  1. Evaluating CoLiDeS + Pic: The Role of Relevance of Pictures in User Navigation Behaviour

    Science.gov (United States)

    Karanam, Saraschandra; van Oostendorp, Herre; Indurkhya, Bipin

    2012-01-01

    CoLiDeS + Pic is a cognitive model of web-navigation that incorporates semantic information from pictures into CoLiDeS. In our earlier research, we have demonstrated that by incorporating semantic information from pictures, CoLiDeS + Pic can predict the hyperlinks on the shortest path more frequently, and also with greater information scent,…

  2. The Serine Protease Pic From Enteroaggregative Escherichia coli Mediates Immune Evasion by the Direct Cleavage of Complement Proteins.

    Science.gov (United States)

    Abreu, Afonso G; Fraga, Tatiana R; Granados Martínez, Adriana P; Kondo, Marcia Y; Juliano, Maria A; Juliano, Luiz; Navarro-Garcia, Fernando; Isaac, Lourdes; Barbosa, Angela S; Elias, Waldir P

    2015-07-01

    Enteroaggregative and uropathogenic Escherichia coli, Shigella flexneri 2a, and the hybrid enteroaggregative/Shiga toxin-producing E. coli strain (O104:H4) are important pathogens responsible for intestinal and urinary tract infections, as well as sepsis and hemolytic uremic syndrome. They have in common the production of a serine protease called Pic. Several biological roles for Pic have been described, including protection of E. coli DH5α from complement-mediated killing. Hereby we showed that Pic significantly reduces complement activation by all 3 pathways. Pic cleaves purified C3/C3b and other proteins from the classic and lectin pathways, such as C4 and C2. Cleavage fragments of C3, C4, and C2 were also observed with HB101(pPic1) culture supernatants, and C3 cleavage sites were mapped by fluorescence resonance energy transfer peptides. Experiments using human serum as a source of complement proteins confirmed Pic proteolytic activity on these proteins. Furthermore, Pic works synergistically with the human complement regulators factor I and factor H, promoting inactivation of C3b. In the presence of both regulators, further degradation of C3 α' chain was observed. Therefore, Pic may contribute to immune evasion of E. coli and S. flexneri, favoring invasiveness and increasing the severity of the disorders caused by these pathogens.

  3. Evaluation of the progression rate of atrophy lesions in punctate inner choroidopathy (PIC) based on autofluorescence analysis.

    Science.gov (United States)

    Hua, Rui; Liu, Limin; Chen, Lei

    2014-12-01

    To investigate the autofluorescence (AF) characteristics of punctate inner choroidopathy (PIC) and to evaluate the progression rate of retinal pigment epithelium (RPE) atrophy lesions in PIC using confocal scanning laser ophthalmoscopy. Twenty-two eyes of 14 PIC cases and 21 eyes of 21 non-proliferative diabetic retinopathy (NPDR) cases which received retinal coagulation as a control group were enrolled in this study. Enhanced depth imaging optical coherence tomography (EDI-OCT) and AF were recorded from all patients at 18 months follow-up. The RPE atrophy areas of PIC and laser scars in NPDR were analyzed using the Region Finder software of the Heidelberg Eye Explorer. This software allows direct export of AF images from the database and semi-automated detection of atrophic areas by shadow correction, vessel detection, and selection of seed points. At baseline, both hyperfluorescence and hypofluorescence were observed in the lesions of PIC eyes with a focal elevation of RPE and corresponding disruption of the ellipsoid region of the inner segment ellipsoid zone (EZ). In contrast, hypo-AF was detected when there was a lack of RPE. The mean progression rate of RPE atrophy in PIC and NPDR were 3.735 mm(2)/year (0.056-0.545) and 0.127 mm(2)/year (0.015-0.466), respectively. Compared with the atrophy area in the last visit, the progression rate in PIC was significantly greater than that in NPDR (Z=5.615, P<0.0001). The results of AF reflect the status of PIC and the progression rate of RPE atrophy in PIC, which can be used to predict the progress of PIC noninvasively. Copyright © 2014 Elsevier B.V. All rights reserved.

  4. Rise time of proton cut-off energy in 2D and 3D PIC simulations

    CERN Document Server

    Babaei, Javad; Londrillo, Pasquale; Mirzanejad, Saeed; Rovelli, Tiziano; Sinigardi, Stefano; Turchetti, Giorgio

    2016-01-01

    The Target Normal Sheath Acceleration (TNSA) regime for proton acceleration by laser pulses is experimentally consolidated and fairly well understood. However, uncertainties remain in the analysis of particle-in-cell (PIC) simulation results. The energy spectrum is exponential with a cut-off, but the maximum energy depends on the simulation time, following different laws in two and three dimensional (2D, 3D) PIC simulations, so that the determination of an asymptotic value has some arbitrariness. We propose two empirical laws for rise time of the cut-off energy in 2D and 3D PIC simulations, suggested by a model in which the proton acceleration is due to a surface charge distribution on the target rear side. The kinetic energy of the protons that we obtain follows two distinct laws, which appear to be nicely satisfied by PIC simulations. The laws depend on two parameters: the scaling time, at which the energy starts to rise, and the asymptotic cut-off energy. The values of the cut-off energy, obtained by fitti...

  5. Validation of the Offending-Related Attitudes Questionnaire of CRIME-PICS II Scale (Chinese)

    Science.gov (United States)

    Chui, Wing Hong; Wu, Joseph; Kwok, Yan Yuen; Liu, Liu

    2017-01-01

    This study examined the factor structure, reliability, and validity of the first part of the Chinese version of the CRIME-PICS II Scale, a self-administrated instrument assessing offending-related attitudes. Data were collected from three samples: male Hong Kong young offenders, female Mainland Chinese prisoners, and Hong Kong college students.…

  6. Tissue accumulation and urinary excretion of Cr in chromium picolinate (CrPic)-supplemented lambs.

    Science.gov (United States)

    Dallago, Bruno Stéfano Lima; Lima, Bárbara Alcântara Ferreira; Braz, Shélida Vasconcelos; Mustafa, Vanessa da Silva; McManus, Concepta; Paim, Tiago do Prado; Campeche, Aline; Gomes, Edgard Franco; Louvandini, Helder

    2016-05-01

    Chromium (Cr) concentrations in liver, kidney, spleen, heart, lymph node, skeletal muscle, bone, testis and urine of lambs were measured to trace the biodistribution and bioaccumulation of Cr after oral supplementation with chromium picolinate (CrPic). Twenty-four Santa Inês lambs were treated with four different concentrations of CrPic: placebo, 0.250, 0.375 and 0.500 mg of CrPic/animal/day for 84 days. The basal diet consisted of Panicum maximum cv Massai hay and concentrate. Cr concentrations were measured by ICP-MS measuring (52)Cr as collected mass. There was a positive linear relationship between dose administered and the accumulation of Cr in the heart, lungs and testis. Urinary excretion of Cr occurred in a time and dose-dependent manner, so the longer or more dietary Cr provided, the greater excretion of the element. As some non-carcass components (such as lungs or heart) are added to bone and visceral meal to feed animals, there is a risk of bioaccumulation and biomagnification due to Cr offered as CrPic in the diet.

  7. The LHC Tier1 at PIC: experience from first LHC run

    CERN Document Server

    Flix, J; Acción, E; Acin, V; Acosta, C; Bernabeu, G; Bria, A; Casals, J; Caubet, M; Cruz, R; Delfino, M; Espinal, X; Lanciotti, E; López, F; Martinez, F; Méndez, V; Merino, G.; Pacheco, A.; Planas, E.; Porto, M C; Rodríguez, B; Sedov, A

    2013-01-01

    This paper summarizes the operational experience of the Tier1 computer center at Port d’Informació Científica (PIC) supporting the commissioning and first run (Run1) of the Large Hadron Collider (LHC). The evolution of the experiment computing models resulting from the higher amounts of data expected after the restart of the LHC are also described.

  8. An algorithm for reducing PIC ensembles with exact conservation of distribution functions and conservation laws

    CERN Document Server

    Gonoskov, Arkady

    2016-01-01

    We propose an algorithm for reducing the number of macro-particles in PIC simulations in such a way that an arbitrary number of conservation laws can be preserved exactly and all the distribution functions are not modified in any other way than due to the statistical noise.

  9. The Whole PIC Catalog: Organization, Planning and Service Delivery Options under JTPA.

    Science.gov (United States)

    National Alliance of Business, Inc., Washington, DC.

    This handbook illustrates and discusses organizational options for the delivery of employment and training services within service delivery areas (SDAs) mandated by the Job Training Partnership Act (JTPA) of 1982. Addressed primarily to members of private industry councils (PICs), representatives of local governments, and employment and training…

  10. The Plant Information Center (PIC): A Web-Based Learning Center for Botanical Study.

    Science.gov (United States)

    Greenberg, J.; Daniel, E.; Massey, J.; White, P.

    The Plant Information Center (PIC) is a project funded under the Institute of Museum and Library Studies that aims to provide global access to both primary and secondary botanical resources via the World Wide Web. Central to the project is the development and employment of a series of applications that facilitate resource discovery, interactive…

  11. A study on the apterous genus Clytomelegena Pic, 1928 (Coleoptera, Disteniidae).

    Science.gov (United States)

    Lin, Meiying; Murzin, Sergey V

    2012-01-01

    The genus Noeconia Murzin, 1988 is synonymized with Clytomelegena Pic, 1928. Clytomelegena kabakovi (Murzin, 1988), comb. n. is newly recorded from China (Guangxi Prov.). And Laos (Attapeu Prov.) is a new locality of this genus. Both sexes are apterous. Photographs and genitalic descriptions of Clytomelegena kabakovi are presented for the first time.

  12. Synopsis of Falsocis Pic (Coleoptera, Ciidae), new species, new records and an identification key.

    Science.gov (United States)

    Lopes-Andrade, Cristiano; Lawrence, John F

    2011-01-01

    Three new species of Falsocis Pic are described: Falsocis aquiloniussp. n. from Panamá, Costa Rica and Colombia, Falsocis egregiussp. n. from a single locality in northern Brazil and Falsocis occultussp. n. from two localities in southeastern and southern Brazil. New records, comparative notes and an identification key for male and female specimens of Falsocis species are also provided.

  13. Adaptive DSP Algorithms for UMTS: Blind Adaptive MMSE and PIC Multiuser Detection

    NARCIS (Netherlands)

    Potman, Jordy

    2003-01-01

    A study of the application of blind adaptive Minimum Mean Square Error (MMSE) and Parallel Interference Cancellation (PIC) multiuser detection techniques to Wideband Code Division Multiple Access (WCDMA), the physical layer of Universal Mobile Telecommunication System (UMTS), has been performed as p

  14. PIC Profiles for Learning-Disabled and Behavior-Disordered Children.

    Science.gov (United States)

    Goh, David S.; And Others

    1984-01-01

    Compared the performance of learning-disabled and behavior-disordered children (N=60) on the Personality Inventory for Children (PIC). Results showed that learning-disabled and behavior-disordered children could be differentiated clearly on subtests that comprise the cognitive development and conduct disorder factors. However, less differentiation…

  15. EXPERIMENTAL INVESTIGATION OF PIC FORMATION DURING THE INCINERATION OF RECOVERED CFC-11

    Science.gov (United States)

    The report gives results of an investigation of the formation of products of incomplete combustion (PICS) during "recovered" trichlorofluoromethane (CFC-11) incineration. Tests involved burning the recovered CFC-11 in a propane gas flame. combustion gas samples were taken and an...

  16. PIC--A Self-Paced Practical Communications Program for Technical/Vocational Students.

    Science.gov (United States)

    Blicq, Ronald S.

    The Practical Industrial Communication (PIC) program is a form of individualized instruction that teaches communication skills to students in vocational/technical curricula at Red River Community College, Winnipeg, Manitoba. A placement test determines whether students begin with all or part of a ten-hour writing skills review or proceed directly…

  17. The LHC Tier1 at PIC: experience from first LHC run

    Directory of Open Access Journals (Sweden)

    Flix J.

    2013-11-01

    Full Text Available This paper summarizes the operational experience of the Tier1 computer center at Port d’InformacióCientífica (PIC supporting the commissioning and first run (Run1 of the Large Hadron Collider (LHC. Theevolution of the experiment computing models resulting from the higher amounts of data expected after therestart of the LHC are also described.

  18. Complex

    African Journals Online (AJOL)

    CLEMENT O BEWAJI

    Schiff bases and their complex compounds have been studied for their .... establishing coordination of the N–(2 – hydroxybenzyl) - L - α - valine Schiff base ..... (1967); “Spectrophotometric Identification of Organic Compounds”, Willey, New.

  19. Molecular architecture of the preinitiation complex in adenovirus DNA replication

    OpenAIRE

    Mysiak, Monika Elzbieta

    2004-01-01

    After infection of a host cell, adenovirus (Ad) aims for generation of progeny viruses, and thus it rapidly replicates its genomic DNA. The replication process starts with the assembly of the preinitiation complex (PIC) on the origin DNA. The PIC consists of three viral proteins, DNA polymerase (pol), precursor terminal protein (pTP), DNA binding protein (DBP) and two transcription factors of the host cell, Nuclear Factor I (NFI) and Octamer binding protein (Oct-1). Both transcription factors...

  20. Polymeric complex micelle loaded with axially substituted silicon(Ⅳ) phthalocyanine

    Institute of Scientific and Technical Information of China (English)

    Bao Quan Huang

    2009-01-01

    A novel axially substituted silicon(IV) phthalocyanine,namely di-pyridyloxy axially substituted silicon(Ⅳ) phthalocyanine 2 was synthesized and characterized by UV/vis,IR,elemental analysis,MS as well as 1H NMR spectroscopy.Hydrophobic 2 was encapsulated by amphiphilic triblock copolymer poly[Nε-(benzyloxycarbonyl-lysine]-poly(ethylene glycol)-poly [Nε-(benzyl oxycarbonyl) (PLL(Z)-b-PEG-b-PLL(Z)) to form hydrophobic 2-loaded polymeric complex miceile (PIC) (2-loaded PIC).Atom force microscopy (AFM) image showed that 2-loaded PIC formed a spherical nanocarrier with approximately 35-50 nm in diameter.The fluorescence intensity and lifetime of 2-loaded PIC was significantly enhanced by the incorporation 2 into PIC nanocarrier.

  1. Comparison of different Maxwell solvers coupled to a PIC resolution method of Maxwell-Vlasov equations; Evaluation de differents solveurs Maxwell pour la resolution de Maxwell-Vlasov par une methode PIC

    Energy Technology Data Exchange (ETDEWEB)

    Fochesato, Ch. [CEA Bruyeres-le-Chatel, Dept. de Conception et Simulation des Armes, Service Simulation des Amorces, Lab. Logiciels de Simulation, 91 (France); Bouche, D. [CEA Bruyeres-le-Chatel, Dept. de Physique Theorique et Appliquee, Lab. de Recherche Conventionne, Centre de Mathematiques et Leurs Applications, 91 (France)

    2007-07-01

    The numerical solution of Maxwell equations is a challenging task. Moreover, the range of applications is very wide: microwave devices, diffraction, to cite a few. As a result, a number of methods have been proposed since the sixties. However, among all these methods, none has proved to be free of drawbacks. The finite difference scheme proposed by Yee in 1966, is well suited for Maxwell equations. However, it only works on cubical mesh. As a result, the boundaries of complex objects are not properly handled by the scheme. When classical nodal finite elements are used, spurious modes appear, which spoil the results of simulations. Edge elements overcome this problem, at the price of rather complex implementation, and computationally intensive simulations. Finite volume methods, either generalizing Yee scheme to a wider class of meshes, or applying to Maxwell equations methods initially used in the field of hyperbolic systems of conservation laws, are also used. Lastly, 'Discontinuous Galerkin' methods, generalizing to arbitrary order of accuracy finite volume methods, have recently been applied to Maxwell equations. In this report, we more specifically focus on the coupling of a Maxwell solver to a PIC (Particle-in-cell) method. We analyze advantages and drawbacks of the most widely used methods: accuracy, robustness, sensitivity to numerical artefacts, efficiency, user judgment. (authors)

  2. Electron paramagnetic resonance spectral study of [Mn(acs){sub 2}(2–pic){sub 2}(H{sub 2}O){sub 2}] single crystals

    Energy Technology Data Exchange (ETDEWEB)

    Kocakoç, Mehpeyker, E-mail: mkocakoc@cu.edu.tr [Çukurova University (Turkey); Tapramaz, Recep, E-mail: recept@omu.edu.tr [Ondokuz Mayıs University (Turkey)

    2016-03-25

    Acesulfame potassium salt is a synthetic and non-caloric sweetener. It is also important chemically for its capability of being ligand in coordination compounds, because it can bind over Nitrogen and Oxygen atoms of carbonyl and sulfonyl groups and ring oxygen. Some acesulfame containing transition metal ion complexes with mixed ligands exhibit solvato and thermo chromic properties and these properties make them physically important. In this work single crystals of Mn{sup +2} ion complex with mixed ligand, [Mn(acs){sub 2}(2-pic){sub 2}(H{sub 2}O){sub 2}], was studied with electron paramagnetic resonance (EPR) spectroscopy. EPR parameters were determined. Zero field splitting parameters indicated that the complex was highly symmetric. Variable temperature studies showed no detectable chance in spectra.

  3. A temperature supervisory system based on PIC18F248%基于PIC18F248的温度监控系统的研究

    Institute of Scientific and Technical Information of China (English)

    王欣欣; 高勇伟

    2008-01-01

    为了监控大电流磁体电源的温度变化,采用微处理器PIC18F248进行实时监控.首先设计传感器DS18B20的调理电路,通过添加共模抑制线圈提高系统的抗干扰能力,然后利用CAN总线完成多路多点的数据采集,最后采用LabVIEW驱动CAN接口卡并设计系统接收界面.

  4. The Pic protease of enteroaggregative Escherichia coli promotes intestinal colonization and growth in the presence of mucin.

    Science.gov (United States)

    Harrington, Susan M; Sheikh, Jalaluddin; Henderson, Ian R; Ruiz-Perez, Fernando; Cohen, Paul S; Nataro, James P

    2009-06-01

    Enteroaggregative Escherichia coli (EAEC) is increasingly being recognized as a cause of diarrheal disease in diverse populations. No small animal model is currently available to study this pathogen. We report here that conventional mice orally inoculated with prototype EAEC strain 042 generally became colonized, though the abundance of organisms cultured from their stool varied substantially among individual animals. In contrast, mice whose water contained 5 g/liter streptomycin consistently became colonized at high levels (ca. 10(8) CFU/g of stool). Neither conventional nor streptomycin-treated mice developed clinical signs or histopathologic abnormalities. Using specific mutants in competition with the wild-type strain, we evaluated the contribution of several putative EAEC virulence factors to colonization of streptomycin-treated mice. Our data suggest that the dispersin surface protein and Pic, a serine protease autotransporter secreted by EAEC and Shigella flexneri, promote colonization of the mouse. In contrast, we found no role for the aggregative adherence fimbriae, the transcriptional activator AggR, or the surface factor termed Air (enteroaggregative immunoglobulin repeat protein). To study Pic further, we constructed a single nucleotide mutation in strain 042 which altered only the Pic catalytic serine (strain 042PicS258A). Fractionation of the tissue at 24 h and 3 days demonstrated an approximate 3-log(10) difference between 042 and 042PicS258A in the lumen and mucus layer and adherent to tissue. Strains 042 and 042PicS258A adhered similarly to mouse tissue ex vivo. While no growth differences were observed in a continuous-flow anaerobic intestinal simulator system, the wild-type strain exhibited a growth advantage over 042PicS258A in a culture of cecal mucus and in cecal contents in vitro; this difference was manifest only after 6 h of growth. Moreover, enhanced growth of the wild type was observed in comparison with that of the mutant in minimal

  5. Numerical modeling of the Linac4 negative ion source extraction region by 3D PIC-MCC code ONIX

    CERN Document Server

    Mochalskyy, S; Minea, T; Lifschitz, AF; Schmitzer, C; Midttun, O; Steyaert, D

    2013-01-01

    At CERN, a high performance negative ion (NI) source is required for the 160 MeV H- linear accelerator Linac4. The source is planned to produce 80 mA of H- with an emittance of 0.25 mm mradN-RMS which is technically and scientifically very challenging. The optimization of the NI source requires a deep understanding of the underling physics concerning the production and extraction of the negative ions. The extraction mechanism from the negative ion source is complex involving a magnetic filter in order to cool down electrons’ temperature. The ONIX (Orsay Negative Ion eXtraction) code is used to address this problem. The ONIX is a selfconsistent 3D electrostatic code using Particles-in-Cell Monte Carlo Collisions (PIC-MCC) approach. It was written to handle the complex boundary conditions between plasma, source walls, and beam formation at the extraction hole. Both, the positive extraction potential (25kV) and the magnetic field map are taken from the experimental set-up, in construction at CERN. This contrib...

  6. The serine protease motif of Pic mediates a dose-dependent mucolytic activity after binding to sugar constituents of the mucin substrate.

    Science.gov (United States)

    Gutiérrez-Jiménez, Javier; Arciniega, Ivonne; Navarro-García, Fernando

    2008-08-01

    The pic gene is harbored on the chromosomes of three important pathogens: enteroaggregative Escherichia coli (EAEC), uropathogenic E. coli (UPEC), and Shigella flexneri. Since Pic is secreted into the intestinal lumen during EAEC infection, we sought to identify intestinal-mucosal substrates for Pic. Pic did not damage epithelial cells, cleave fodrin, or degrade host defense proteins embedded in the mucus layer (sIgA, lactoferrin and lysozyme). However, by using a solid-phase assay to evaluate the mucinolytic activity of EAEC Pic, we documented a specific, dose-dependent mucinolytic activity. A serine protease inhibitor and an enzymatically inactive variant of Pic were used to show that the Pic serine protease motif is required for mucinolytic activity. Pic binds mucin, and this binding was blocked in competition assays using monosaccharide constituents of the oligosaccharide side chains of mucin. Moreover, Pic mucinolytic activity decreased when sialic acid was removed from mucin. Thus, Pic is a mucinase with lectin-like activity that can be related to its reported hemagglutinin activity. Our results suggest that EAEC may secrete Pic into the intestinal lumen as a strategy for penetrating the gel-like mucus layer during EAEC colonization.

  7. A maximum power point tracker for photovoltaic system using a PIC microcontroller; Controlador de potencia maxima para sistemas fotovoltaicos (SFVs) utilizando un microcontrolador PIC

    Energy Technology Data Exchange (ETDEWEB)

    Guzman, Eusebio; Mendoza, Victor X; Carrillo, Jose J . A; Galarza, Cristian [Universidad Autonoma Metropolitana, Mexico, D.F. (Mexico)

    2000-07-01

    A maximum power point tracker MPPT for photovoltaic systems is presented. The equipment can output up to 600 W and its control signals are generated by a PIC microcontroller. The principle of control is based on current and voltage sampling at the output terminals of the photovoltaic generator. From power comparison of two consecutive samples, it is possible to know how far from the optimal point the system is working. Output voltage control is used to force the system to work within the optimal area of operation. The microcontroller program sequence, the DC/DC converter structure and the most relevant results are shown. [Spanish] En este trabajo se presenta el desarrollo de un controlador de potencia maxima para su aplicacion en sistemas fotovoltaicos (SFVs). El diseno alcanza una potencia de 600 W y sus senales de control son generadas con un controlador PIC. El principio de control se basa en el muestreo de la corriente y la tension en las terminadas del generador fotovoltaico GFV. De dos muestreos consecutivos, y por comparacion de las potencias, se determina que tan alejado del punto optimo opera el sistema. La operacion del sistema dentro de la zona de funcionamiento optimo se asegura mediante un control por tension. Se muestra la secuencia de programacion del microcontrolador, la estructura del convertidor CD/CD empleado y algunos resultados relevantes.

  8. Advanced fluid modelling and PIC/MCC simulations of low-pressure ccrf discharges

    CERN Document Server

    Becker, Markus M; Sun, Anbang; Bonitz, Michael; Loffhagen, Detlef

    2016-01-01

    Comparative studies of capacitively coupled radio-frequency discharges in helium and argon at pressures between 10 and 80 Pa are presented applying two different fluid modelling approaches as well as two independently developed particle-in-cell/Monte Carlo collision (PIC/MCC) codes. The focus is on the analysis of the range of applicability of a recently proposed fluid model including an improved drift-diffusion approximation for the electron component as well as its comparison with fluid modelling results using the classical drift-diffusion approximation and benchmark results obtained by PIC/MCC simulations. Main features of this time- and space-dependent fluid model are given. It is found that the novel approach shows generally quite good agreement with the macroscopic properties derived by the kinetic simulations and is largely able to characterize qualitatively and quantitatively the discharge behaviour even at conditions when the classical fluid modelling approach fails. Furthermore, the excellent agreem...

  9. Developments of a large area VUV sensitive gas PMT with GEM/muPIC

    Energy Technology Data Exchange (ETDEWEB)

    Sekiya, H [Kamioka Observatory, Institute for Cosmic Ray Research, University of Tokyo, 456 Higashi-Mozumi, Hida, Gifu, 506-1205 (Japan); Ida, C; Kubo, H; Kurosawa, S; Tanimori, T [Department of Physics, Graduate School of Science, Kyoto University, Kitashirakawa-oiwake, Sakyo, Kyoto, 606-8502 (Japan); Yoshikawa, A; Yanagida, T; Yokota, Y [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba, Sendai, Miyagi, 980-8577 (Japan); Fukuda, K; Ishizu, S; Kawaguchi, N; Suyama, T, E-mail: sekiya@icrr.u-tokyo.ac.j [Tokuyama Corporation, 3-3-1 Shibuya, Shibuya, Tokyo, 150-8383 (Japan)

    2009-11-15

    A new large area UV photon detector with micro pattern gaseous detectors is developed and evaluated. A semitransparent CsI photocathode deposited on a MgF{sub 2} window was combined with 10cm x 10cm GEM and muPIC. Using Ar+C{sub 2}H{sub 6} (10%) gas, we achieved the gas gain of more than 10{sup 5} which is enough to detect single photoelectron. We, then, irradiated vacuum UV photons (VUV, around 172nm) from the newly developed LaF{sub 3}(Nd) scintillator to the detector and the single photoelectrons were successfully detected. We also demonstrated the imaging capability of the detector with muPIC readout systems.

  10. A revision of the genus Pseudoechthistatus Pic (Coleoptera, Cerambycidae, Lamiinae, Lamiini).

    Science.gov (United States)

    Bi, Wen-Xuan; Lin, Mei-Ying

    2016-01-01

    The genus Pseudoechthistatus Pic, 1917 is redefined and revised. Five species of the genus are described as new, Pseudoechthistatus sinicus sp. n. and Pseudoechthistatus chiangshunani sp. n. from central Yunnan, China, Pseudoechthistatus pufujiae sp. n. from western Yunnan, China, and Pseudoechthistatus holzschuhi sp. n. and Pseudoechthistatus glabripennis sp. n. from southern Yunnan and northern Vietnam. Pseudoechthistatus birmanicus Breuning, 1942 is excluded from the fauna of China. Three poorly known species, Pseudoechthistatus obliquefasciatus Pic, 1917, Pseudoechthistatus granulatus Breuning, 1942, and Pseudoechthistatus acutipennis Chiang, 1981 are redescribed, and the type localities of the former two species are discussed. Endophallic structure of seven species in inflated and everted condition are studied and compared with their relatives. Illustrations of habitus and major diagnostic features of all species are provided. Some biological notes are reported. An identification key as well as a distributional map are presented.

  11. Performance and capacity analysis of Poisson photon-counting based Iter-PIC OCDMA systems.

    Science.gov (United States)

    Li, Lingbin; Zhou, Xiaolin; Zhang, Rong; Zhang, Dingchen; Hanzo, Lajos

    2013-11-04

    In this paper, an iterative parallel interference cancellation (Iter-PIC) technique is developed for optical code-division multiple-access (OCDMA) systems relying on shot-noise limited Poisson photon-counting reception. The novel semi-analytical tool of extrinsic information transfer (EXIT) charts is used for analysing both the bit error rate (BER) performance as well as the channel capacity of these systems and the results are verified by Monte Carlo simulations. The proposed Iter-PIC OCDMA system is capable of achieving two orders of magnitude BER improvements and a 0.1 nats of capacity improvement over the conventional chip-level OCDMA systems at a coding rate of 1/10.

  12. Taxonomic note and description of new species of Fissocantharis Pic from China (Coleoptera, Cantharidae).

    Science.gov (United States)

    Yang, Yuxia; Su, Junyan; Yang, Xingke

    2014-01-01

    Two new species of Fissocantharis Pic are described, Fissocantharisbifoveatus sp. n. (CHINA: Yunnan) and Fissocantharisacuticollis sp. n. (CHINA: Zhejiang, Fujian, Guangdong, Hunan). Fissocantharispieli (Pic, 1937) is redescribed and Fissocanthariskontumensis Wittmer, 1989 is provided with a supplementary description. Fissocantharisshanensis (Wittmer, 1997) is synonymized with Fissocanthariskontumensis. For the above four species, illustrations of male genitalia are provided, for the latter three also photos of female genitalia and abdominal sternites VIII, and for the new species photos of male habitus and antennae are presented. Additionally, the specific name of Fissocanthariswittmeri (Y. Yang et X. Yang, 2009), preoccupied by Fissocanthariswittmeri (Kazantsev, 2007), is replaced by Fissocanthariswalteri Y. Yang et X. Yang, nom. n. And Fissocanthariswittmeri (Kazantsev, 2007) is found to be a junior objective synonym of Fissocantharisdenominata (Wittmer, 1997).

  13. Using the PIC16F84 Microcontroller in Intelligent Stepper Motor Control

    OpenAIRE

    Popovici Adrian; Băbăiţă Mircea; Papazian Petru

    2008-01-01

    For applications requiring critical rotorpositioning, usually stepper motors are the bestchoice. Stepper motors operate differently fromother motors; rather than voltage being appliedand the rotor spinning smoothly, stepper motorsturn on a series of electrical pulses to the motor'swindings. Each pulse rotates the rotor by an exactdegree and a series of pulses must be generated toperform a complete rotation. An intelligentcontrolling device was conceived and built basedon a PIC16F84 microcontr...

  14. Elimination of the numerical Cerenkov instability for spectral EM-PIC codes

    CERN Document Server

    Yu, Peicheng; Decyk, Viktor K; Fiuza, F; Vieira, Jorge; Tsung, Frank S; Fonseca, Ricardo A; Lu, Wei; Silva, Luis O; Mori, Warren B

    2014-01-01

    When using an electromagnetic particle-in-cell (EM-PIC) code to simulate a relativistically drifting plasma, a violent numerical instability known as the numerical Cerenkov instability (NCI) occurs. The NCI is due to the unphysical coupling of electromagnetic waves on a grid to wave-particle resonances, including aliased resonances, i.e., $\\omega + 2\\pi\\mu/\\Delta t=(k_1+ 2\\pi\

  15. Automatic Color Sorting Machine Using TCS230 Color Sensor And PIC Microcontroller

    OpenAIRE

    Kunhimohammed C K; Muhammed Saifudeen K K; Sahna S; Gokul M S; Shaeez Usman Abdulla

    2015-01-01

    Sorting of products is a very difficult industrial process. Continuous manual sorting creates consistency issues. This paper describes a working prototype designed for automatic sorting of objects based on the color. TCS230 sensor was used to detect the color of the product and the PIC16F628A microcontroller was used to control the overall process. The identification of the color is based on the frequency analysis of the output of TCS230 sensor. Two conveyor belts were used, each ...

  16. PIC simulations of the production of high-quality electron beams via laser-plasma interaction

    Energy Technology Data Exchange (ETDEWEB)

    Benedetti, C. [Department of Physics, University of Bologna and INFN/Bologna, Via Irnerio 46, 40126 Bologna (Italy)], E-mail: carlo.benedetti@bo.infn.it; Londrillo, P. [INAF, Osservatorio Astronomico di Bologna, Via Ranzani 1, 40127 Bologna (Italy); Petrillo, V.; Serafini, L. [INFN/Milano, Via Celoria 14, 10133 Milano (Italy); Sgattoni, A. [Department of Physics, University of Bologna and INFN/Bologna, Via Irnerio 46, 40126 Bologna (Italy); Tomassini, P. [INFN/Milano, Via Celoria 14, 10133 Milano (Italy); Turchetti, G. [Department of Physics, University of Bologna and INFN/Bologna, Via Irnerio 46, 40126 Bologna (Italy)

    2009-09-01

    We present some numerical studies and parameter scans performed with the electromagnetic, relativistic, fully self-consistent Particle-In-Cell (PIC) code ALaDyn (Acceleration by LAser and DYNamics of charged particles), concerning the generation of a low emittance, high charge and low momentum spread electron bunch from laser-plasma interaction in the Laser WakeField Acceleration (LWFA) regime, in view of achieving beam brightness of interest for FEL applications.

  17. Rise time of proton cut-off energy in 2D and 3D PIC simulations

    Science.gov (United States)

    Babaei, J.; Gizzi, L. A.; Londrillo, P.; Mirzanejad, S.; Rovelli, T.; Sinigardi, S.; Turchetti, G.

    2017-04-01

    The Target Normal Sheath Acceleration regime for proton acceleration by laser pulses is experimentally consolidated and fairly well understood. However, uncertainties remain in the analysis of particle-in-cell simulation results. The energy spectrum is exponential with a cut-off, but the maximum energy depends on the simulation time, following different laws in two and three dimensional (2D, 3D) PIC simulations so that the determination of an asymptotic value has some arbitrariness. We propose two empirical laws for the rise time of the cut-off energy in 2D and 3D PIC simulations, suggested by a model in which the proton acceleration is due to a surface charge distribution on the target rear side. The kinetic energy of the protons that we obtain follows two distinct laws, which appear to be nicely satisfied by PIC simulations, for a model target given by a uniform foil plus a contaminant layer that is hydrogen-rich. The laws depend on two parameters: the scaling time, at which the energy starts to rise, and the asymptotic cut-off energy. The values of the cut-off energy, obtained by fitting 2D and 3D simulations for the same target and laser pulse configuration, are comparable. This suggests that parametric scans can be performed with 2D simulations since 3D ones are computationally very expensive, delegating their role only to a correspondence check. In this paper, the simulations are carried out with the PIC code ALaDyn by changing the target thickness L and the incidence angle α, with a fixed a0 = 3. A monotonic dependence, on L for normal incidence and on α for fixed L, is found, as in the experimental results for high temporal contrast pulses.

  18. Controlling DC Motor using Microcontroller (PIC16F72) with PWM

    OpenAIRE

    Shruti Shrivastava, Jageshwar Rawat, Amit Agrawal

    2012-01-01

    Motion control plays a vital role in industrial atomization. Different types of motors AC, DC, SERVO or stepper are used depending upon the application; of these DC motors are widely used because of easier controlling. Among the different control methods for DC motor armature voltage control method using pulse width modulation (PWM) is best one. We can realize the PWM using H-bridge built with IGBT switches or transistors. To generate PWM signals we use PIC16F7...

  19. The PIC Cystogram: Its Place in the Treatment Algorithm of Recurrent Febrile UTIs

    OpenAIRE

    Jennifer A. Hagerty; Max Maizels; Cheng, Earl Y.

    2008-01-01

    Purpose. A common pediatric dilemma involves management of children with recurrent febrile urinary tract infections (UTIs) who have normal voiding cystourethrograms. Vesicoureteral reflux (VUR) has been demonstrated in such cases by performing a cystogram which positions the instillation of contrast (PIC) at the ureteral orifice. We describe the evidence supporting this diagnostic test. Materials and Methods. The literature was searched to identify and subsequently evaluate all studies invest...

  20. PIC codes for plasma accelerators on emerging computer architectures (GPUS, Multicore/Manycore CPUS)

    Science.gov (United States)

    Vincenti, Henri

    2016-03-01

    The advent of exascale computers will enable 3D simulations of a new laser-plasma interaction regimes that were previously out of reach of current Petasale computers. However, the paradigm used to write current PIC codes will have to change in order to fully exploit the potentialities of these new computing architectures. Indeed, achieving Exascale computing facilities in the next decade will be a great challenge in terms of energy consumption and will imply hardware developments directly impacting our way of implementing PIC codes. As data movement (from die to network) is by far the most energy consuming part of an algorithm future computers will tend to increase memory locality at the hardware level and reduce energy consumption related to data movement by using more and more cores on each compute nodes (''fat nodes'') that will have a reduced clock speed to allow for efficient cooling. To compensate for frequency decrease, CPU machine vendors are making use of long SIMD instruction registers that are able to process multiple data with one arithmetic operator in one clock cycle. SIMD register length is expected to double every four years. GPU's also have a reduced clock speed per core and can process Multiple Instructions on Multiple Datas (MIMD). At the software level Particle-In-Cell (PIC) codes will thus have to achieve both good memory locality and vectorization (for Multicore/Manycore CPU) to fully take advantage of these upcoming architectures. In this talk, we present the portable solutions we implemented in our high performance skeleton PIC code PICSAR to both achieve good memory locality and cache reuse as well as good vectorization on SIMD architectures. We also present the portable solutions used to parallelize the Pseudo-sepctral quasi-cylindrical code FBPIC on GPUs using the Numba python compiler.

  1. Using the PIC16F84 Microcontroller in Intelligent Stepper Motor Control

    Directory of Open Access Journals (Sweden)

    Popovici Adrian

    2008-05-01

    Full Text Available For applications requiring critical rotorpositioning, usually stepper motors are the bestchoice. Stepper motors operate differently fromother motors; rather than voltage being appliedand the rotor spinning smoothly, stepper motorsturn on a series of electrical pulses to the motor'swindings. Each pulse rotates the rotor by an exactdegree and a series of pulses must be generated toperform a complete rotation. An intelligentcontrolling device was conceived and built basedon a PIC16F84 microcontroller and UFDC-1interface.

  2. Operational Test Report (OTR) for U-102 Pumping and Instrumentation and Control (PIC) Skid

    Energy Technology Data Exchange (ETDEWEB)

    KOCH, M.R.

    2000-02-28

    Attached is the completed Operation Test Procedure (OTP-200-004, Rev. A-19 and Rev. A-20). OTP includes a print out of the Programmable Logic Controller (PLC) Ladder Diagram. Ladder Diagram was designed for installation in the PLC used to monitor and control pumping activity for Tank Farm 241-U-102. The completed OTP and OTR are referenced in the IS PIC Skid Configuration Drawing (H-2-829998).

  3. Operational Test Report (OTR) for U-103 Pumping and Instrumentation and Control (PIC) Skid

    Energy Technology Data Exchange (ETDEWEB)

    KOCH, M.R.

    2000-02-28

    Attached is the completed Operation Test Procedure (OTP-200-004, Rev. A-16). OTP includes a print out of the Programmable Logic Controller (PLC) Ladder Diagram. Ladder Diagram was designed for installation in the PLC used to monitor and control pumping activity for Tank Farm 241-U-103. The completed OTP and OTR are referenced in the 25 PIC Skid Configuration Drawing (H-2-829998).

  4. Operational Test Report (OTR) for U-105 Pumping and Instrumentation and Control (PIC) Skid

    Energy Technology Data Exchange (ETDEWEB)

    KOCH, M.R.

    2000-02-28

    Attached is the completed Operation Test Procedure (OTP-200-004, Rev. A-18). OTP includes a print out of the Programmable Logic Controller (PLC) Ladder Diagram. Ladder Diagram was designed for installation in the PLC used to monitor and control pumping activity for Tank Farm 241-U-105. The completed OTP and OTR are referenced in the IS PIC Skid Configuration Drawing (H-2-829998).

  5. Exact charge and energy conservation in implicit PIC with mapped computational meshes

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Guangye [ORNL; Barnes, D. C. [Coronado Consulting, Lamy, NM 87540

    2013-01-01

    This paper discusses a novel fully implicit formulation for a one-dimensional electrostatic particle-in-cell (PIC) plasma simulation approach. Unlike earlier implicit electrostatic PIC approaches (which are based on a linearized Vlasov Poisson formulation), ours is based on a nonlinearly converged Vlasov Amp re (VA) model. By iterating particles and fields to a tight nonlinear convergence tolerance, the approach features superior stability and accuracy properties, avoiding most of the accuracy pitfalls in earlier implicit PIC implementations. In particular, the formulation is stable against temporal (Courant Friedrichs Lewy) and spatial (aliasing) instabilities. It is charge- and energy-conserving to numerical round-off for arbitrary implicit time steps (unlike the earlier energy-conserving explicit PIC formulation, which only conserves energy in the limit of arbitrarily small time steps). While momentum is not exactly conserved, errors are kept small by an adaptive particle sub-stepping orbit integrator, which is instrumental to prevent particle tunneling (a deleterious effect for long-term accuracy). The VA model is orbit-averaged along particle orbits to enforce an energy conservation theorem with particle sub-stepping. As a result, very large time steps, constrained only by the dynamical time scale of interest, are possible without accuracy loss. Algorithmically, the approach features a Jacobian-free Newton Krylov solver. A main development in this study is the nonlinear elimination of the new-time particle variables (positions and velocities). Such nonlinear elimination, which we term particle enslavement, results in a nonlinear formulation with memory requirements comparable to those of a fluid computation, and affords us substantial freedom in regards to the particle orbit integrator. Numerical examples are presented that demonstrate the advertised properties of the scheme. In particular, long-time ion acoustic wave simulations show that numerical accuracy

  6. Taxonomic notes relating to Glenea diversenotata Schwarzer and G. quadriguttata Pic (Coleoptera, Cerambycidae, Lamiinae).

    Science.gov (United States)

    Lin, Mei-Ying; Lingafelter, Steven W

    2016-01-01

    Glenea diversenotata Schwarzer, 1925 is reinstated from a subspecies of Glenea tonkinea Aurivillius, 1925 to species level and Glenea neohumerosa Lin & Yang, 2011 is a new junior synonym. Some biological information on Glenea diversenotata is recorded for the first time, including pictures of the larva and pupa. Glenea quadriguttata Pic, 1926 is reinstated from a subspecies of Glenea lacteomaculata Schwarzer, 1925 to species level. Lectotypes for Glenea lacteomaculata and Glenea quadriguttata are designated. A modified key to the related species is presented.

  7. Control of ammonia and urea emissions from urea manufacturing facilities of Petrochemical Industries Company (PIC), Kuwait.

    Science.gov (United States)

    Khan, A R; Al-Awadi, L; Al-Rashidi, M S

    2016-06-01

    Petrochemical Industries Company (PIC) in Kuwait has mitigated the pollution problem of ammonia and urea dust by replacing the melting and prilling units of finished-product urea prills with an environmentally friendly granulation process. PIC has financed a research project conducted by the Coastal and Air Pollution Program's research staff at the Kuwait Institute for Scientific Research to assess the impact of pollution control strategies implemented to maintain a healthy productive environment in and around the manufacturing premises. The project was completed in three phases: the first phase included the pollution monitoring of the melting and prilling units in full operation, the second phase covered the complete shutdown period where production was halted completely and granulation units were installed, and the last phase encompassed the current modified status with granulation units in full operation. There was substantial decrease in ammonia emissions, about 72%, and a 52.7% decrease in urea emissions with the present upgrading of old melting and prilling units to a state-of-the-art technology "granulation process" for a final finished product. The other pollutants, sulfur dioxide (SO2), nitrogen oxides (NOx), and volatile organic compounds (VOCs), have not shown any significant change, as the present modification has not affected the sources of these pollutants. Petrochemical Industries Company (PIC) in Kuwait has ammonia urea industries, and there were complaints about ammonia and urea dust pollution. PIC has resolved this problem by replacing "melting and prilling unit" of final product urea prills by more environmentally friendly "granulation unit." Environmental Pollution and Climate Program has been assigned the duty of assessing the outcome of this change and how that influenced ammonia and urea dust emissions from the urea manufacturing plant.

  8. Fast-ignition design transport studies: realistic electron source, integrated PIC-hydrodynamics, imposed magnetic fields

    CERN Document Server

    Strozzi, D J; Larson, D J; Divol, L; Kemp, A J; Bellei, C; Marinak, M M; Key, M H

    2012-01-01

    Transport modeling of idealized, cone-guided fast ignition targets indicates the severe challenge posed by fast-electron source divergence. The hybrid particle-in-cell [PIC] code Zuma is run in tandem with the radiation-hydrodynamics code Hydra to model fast-electron propagation, fuel heating, and thermonuclear burn. The fast electron source is based on a 3D explicit-PIC laser-plasma simulation with the PSC code. This shows a quasi two-temperature energy spectrum, and a divergent angle spectrum (average velocity-space polar angle of 52 degrees). Transport simulations with the PIC-based divergence do not ignite for > 1 MJ of fast-electron energy, for a modest 70 micron standoff distance from fast-electron injection to the dense fuel. However, artificially collimating the source gives an ignition energy of 132 kJ. To mitigate the divergence, we consider imposed axial magnetic fields. Uniform fields ~50 MG are sufficient to recover the artificially collimated ignition energy. Experiments at the Omega laser facil...

  9. Design And Construction Of Digital Multi-Meter Using PIC Microcontroller

    Directory of Open Access Journals (Sweden)

    Khawn Nue

    2015-07-01

    Full Text Available Abstract This thesis describes the design and construction of digital multi-meter using PIC microcontroller. In this system a typical multi-meter may include features such as the ability to measure ACDC voltage DC current resistance temperature diodes frequency and connectivity. This design uses of the PIC microcontroller voltage rectifiers voltage divide potentiometer LCD and other instruments to complete the measure. When we used what we have learned of microprocessors and adjust the program to calculate and show the measures in the LCD keypad selected the modes. The software programming has been incorporated using MPLAB and PROTEUS. In this system the analogue input is taken directly to the analogue input pin of the microcontroller without any other processing. So the input range is from 0V to 5V the maximum source impedance is 2k5 for testing use a 1k pot. To improve the circuit adds an op-amp in front to present greater impedance to the circuit under test. The output impedance of the op-amp will be low which a requirement of the PIC analogue input is.

  10. Advanced fluid modeling and PIC/MCC simulations of low-pressure ccrf discharges

    Science.gov (United States)

    Becker, M. M.; Kählert, H.; Sun, A.; Bonitz, M.; Loffhagen, D.

    2017-04-01

    Comparative studies of capacitively coupled radio-frequency discharges in helium and argon at pressures between 10 and 80 Pa are presented applying two different fluid modeling approaches as well as two independently developed particle-in-cell/Monte Carlo collision (PIC/MCC) codes. The focus is on the analysis of the range of applicability of a recently proposed fluid model including an improved drift-diffusion approximation for the electron component as well as its comparison with fluid modeling results using the classical drift-diffusion approximation and benchmark results obtained by PIC/MCC simulations. Main features of this time- and space-dependent fluid model are given. It is found that the novel approach shows generally quite good agreement with the macroscopic properties derived by the kinetic simulations and is largely able to characterize qualitatively and quantitatively the discharge behavior even at conditions when the classical fluid modeling approach fails. Furthermore, the excellent agreement between the two PIC/MCC simulation codes using the velocity Verlet method for the integration of the equations of motion verifies their accuracy and applicability.

  11. Cosmic rays tracks in the PICsIT instrument onboard the INTEGRAL satellite

    Energy Technology Data Exchange (ETDEWEB)

    Labanti, C. [IASF - CNR/INAF Istituto di Astrofisica Spaziale e Fisica cosmica, sezione di Bologna, Via Gobetti 101, 40129 Bologna (Italy); Marisaldi, M. [IASF - CNR/INAF Istituto di Astrofisica Spaziale e Fisica cosmica, sezione di Bologna, Via Gobetti 101, 40129 Bologna (Italy); Segreto, A. [IASF - CNR/INAF Istituto di Astrofisica Spaziale e Fisica cosmica, sezione di Palermo, Via U. La Malfa 153, 90146 Palermo (Italy)

    2006-01-15

    The PICsIT (PIxelated CsI Telescope) instrument is the high energy plane of the IBIS imager onboard the INTEGRAL satellite, launched on October 2002 and currently fully operative. PICsIT consists of a 64x64 detectors array, each composed of a CsI(Tl) scintillating crystal with p-i-n photodiode readout. Since its first in-orbit activation, several count rate spikes have been detected. The tracks in the detector corresponding to those spikes clearly indicate that their origin is the interaction of cosmic rays with the detector or the satellite structure. Several extended elliptical tracks have been detected, indicating the presence of electromagnetic and hadronic showers initiated by primary cosmic rays interacting with the satellite structure. The tracks morphology and statistics is presented. There is strong evidence that tracks events are due to phosphorescence states excited in the CsI(Tl) crystals by a high energy deposit. Since events due to cosmic rays tracks account for a significant fraction of the instrument background, their rejection is important to improve the instrument sensitivity. Tracks rejection is especially important in those instruments, based on large quantities of alkali halide scintillators, designed to trigger on count rate increases, such as gamma-ray burst monitors. In the PICsIT detector operated in photon-by-photon mode, tracks events rejection can be easily accomplished thanks to the tracks peculiar geometrical and timing characteristics.

  12. Design and implementation of the standards-based personal intelligent self-management system (PICS).

    Science.gov (United States)

    von Bargen, Tobias; Gietzelt, Matthias; Britten, Matthias; Song, Bianying; Wolf, Klaus-Hendrik; Kohlmann, Martin; Marschollek, Michael; Haux, Reinhold

    2013-01-01

    Against the background of demographic change and a diminishing care workforce there is a growing need for personalized decision support. The aim of this paper is to describe the design and implementation of the standards-based personal intelligent care systems (PICS). PICS makes consistent use of internationally accepted standards such as the Health Level 7 (HL7) Arden syntax for the representation of the decision logic, HL7 Clinical Document Architecture for information representation and is based on a open-source service-oriented architecture framework and a business process management system. Its functionality is exemplified for the application scenario of a patient suffering from congestive heart failure. Several vital signs sensors provide data for the decision support system, and a number of flexible communication channels are available for interaction with patient or caregiver. PICS is a standards-based, open and flexible system enabling personalized decision support. Further development will include the implementation of components on small computers and sensor nodes.

  13. The use of polyion complex micelles to enhance the oral delivery of salmon calcitonin and transport mechanism across the intestinal epithelial barrier.

    Science.gov (United States)

    Li, Na; Li, Xin-Ru; Zhou, Yan-Xia; Li, Wen-Jing; Zhao, Yong; Ma, Shu-Jin; Li, Jin-Wen; Gao, Ya-Jie; Liu, Yan; Wang, Xing-Lin; Yin, Dong-Dong

    2012-12-01

    The objective of the present study was to demonstrate the effect of polyanionic copolymer mPEG-grafted-alginic acid (mPEG-g-AA)-based polyion complex (PIC) micelles on enhancing the oral absorption of salmon calcitonin (sCT) in vivo and in vitro and identify the transepithelial transport mechanism of PIC micelles across the intestinal barrier. mPEG-g-AA was first successfully synthesized and characterized in cytotoxicity. The PIC micelles were approximately of 72 nm in diameter with a narrow distribution. The extremely significant enhancement of hypocalcemia efficacy of sCT-loaded PIC micelles in rats was evidenced by intraduodenal administration in comparison with sCT solution. The presence of mPEG-grafted-chitosan in PIC micelles had no favorable effect on this action in the referred content. In the Caco-2 transport studies, PIC micelles could significantly increase the permeability of sCT across Caco-2 monolayers without significantly affecting transepithelial electrical resistance values during the transport study. No evident alterations in the F-actin cytoskeleton were detected by confocal microscope observation following treatment of the cell monolayers with PIC micelles, which further certified the incapacity of PIC micelles to open the intercellular tight junctions. In addition, TEM observations showed that the intact PIC micelles were transported across the everted gut sac. These suggested that the transport of PIC micelles across Caco-2 cell monolayers involve a predominant transcytosis mechanism via endocytosis rather than paracellular pathway. Furthermore, PIC micelles were localized in both the cytoplasm and the nuclei observed by CLSM. Therefore, PIC micelles might be a potentially applicable tool for enhancing the oral absorption of cationic peptide and protein drugs.

  14. Accuracy analysis of a 2D Poisson-Vlasov PIC solver and estimates of the collisional effects in space charge dynamics

    CERN Document Server

    Bazzani, A; Franchi, A; Rambaldi, S; Turchetti, G

    2005-01-01

    We analyze the accuracy of a 2D Poisson-Vlasov PIC integrator, taking the KV as a reference solution for a FODO cell. The particle evolution is symplectic and the Poisson solver is based on FFT. The numerical error, evaluated by comparing the moments of the distribution and the electric field with the exact solution, shows a linear growth. This effect can be modeled by a white noise in the envelope equations for the KV beam. In order to investigate the collisional effects we have integrated the Hamilton's equations for N charged macro-particles with a hard-core r/sub H/ reducing the computational complexity to N/sup 3/2/. In the constant focusing case we observed that a KV beam, matched or mismatched relaxes to the Maxwell-Boltzmann self consistent distribution on a time interval, which depends on r/sub H/ and has a finite limit, for r/sub H/ to 0. A fully 3D PIC code for short bunches was developed for the ADS linac design at LNL (Italy). A 3D particle-core model, based on Langevin's equations with the drift...

  15. The Post-Intensive Care Syndrome (PICS): Impact of ICU-stay on functioning and implications for rehabilitation care

    OpenAIRE

    Dettling-Ihnenfeldt, D.S.

    2017-01-01

    Advancements in critical care medicine result in a growing population of survivors of critical illness. Many intensive care unit (ICU) patients have physical, mental and cognitive sequelae after discharge from the ICU, known as post-intensive care syndrome (PICS). These problems are associated with long-lasting restrictions in daily functioning and reduced health-related quality of life (QoL), and can also negatively affect family members (PICS-F). The nature of these restrictions require int...

  16. The Post-Intensive Care Syndrome (PICS): Impact of ICU-stay on functioning and implications for rehabilitation care

    OpenAIRE

    Dettling-Ihnenfeldt, D.S.

    2017-01-01

    Advancements in critical care medicine result in a growing population of survivors of critical illness. Many intensive care unit (ICU) patients have physical, mental and cognitive sequelae after discharge from the ICU, known as post-intensive care syndrome (PICS). These problems are associated with long-lasting restrictions in daily functioning and reduced health-related quality of life (QoL), and can also negatively affect family members (PICS-F). The nature of these restrictions require int...

  17. iVPIC: A low-­dispersion, energy-­conserving relativistic PIC solver for LPI simulations

    Energy Technology Data Exchange (ETDEWEB)

    Chacon, Luis [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-06-07

    We have developed a novel low-­dispersion, exactly energy-­conserving PIC algorithm for the relativistic Vlasov-­Maxwell system. The approach features an exact energy conservation theorem while preserving the favorable performance and numerical dispersion properties of explicit PIC. The new algorithm has the potential to enable much longer laser-­plasma-­interaction (LPI) simulations than are currently possible.

  18. Near-infrared integral-field spectra of the planet/brown dwarf companion AB Pic b

    CERN Document Server

    Bonnefoy, M; Rojo, P; Allard, F; Lagrange, A -M; Homeier, D; Dumas, C; Beuzit, J -L

    2010-01-01

    Chauvin et al. 2005 imaged a co-moving companion at ~260 AU from the young star AB Pic A. Evolutionary models predictions based on J H K photometry of AB Pic b suggested a mass of ~13 - 14 MJup, placing the object at the deuterium-burning boundary. We used the adaptive-optics-fed integral field spectrograph SINFONI to obtain high quality medium-resolution spectra of AB Pic b (R = 1500-2000) over the 1.1 - 2.5 microns range. Our analysis relies on the comparison of our spectra to young standard templates and to the latest libraries of synthetic spectra developed by the Lyon's Group. AB Pic b is confirmed to be a young early-L dwarf companion. We derive a spectral type L0-L1 and find several features indicative of intermediate gravity atmosphere. A comparison to synthetic spectra yields Teff = 2000+100-300 K and log(g) = 4 +- 0.5 dex. The determination of the derived atmospheric parameters of AB Pic b is limited by a non-perfect match of current atmosphere spectra with our near-infrared observations of AB Pic b...

  19. Kinetics and molecular docking studies of cholinesterase inhibitors derived from water layer of Lycopodiella cernua (L.) Pic. Serm. (II).

    Science.gov (United States)

    Hung, Tran Manh; Lee, Joo Sang; Chuong, Nguyen Ngoc; Kim, Jeong Ah; Oh, Sang Ho; Woo, Mi Hee; Choi, Jae Sue; Min, Byung Sun

    2015-10-05

    Acetylcholinesterase (AChE) inhibitors increase the availability of acetylcholine in central cholinergic synapses and are the most promising drugs currently available for the treatment of Alzheimer's disease (AD). Our screening study indicated that the water fraction of the methanolic extract of Lycopodiella cernua (L.) Pic. Serm. significantly inhibited AChE in vitro. Bioassay-guided fractionation led to the isolation of a new lignan glycoside, lycocernuaside A (12), and fourteen known compounds (1-11 and 13-15). Compound 7 exhibited the most potent AChE inhibitory activity with an IC50 value of 0.23 μM. Compound 15 had the most potent inhibitory activity against BChE and BACE1 with IC50 values of 0.62 and 2.16 μM, respectively. Compounds 4 and 7 showed mixed- and competitive-type AChE inhibition. Compound 7 noncompetitively inhibited BChE whereas 15 showed competitive and 8, 13, and 14 showed mixed-type inhibition. The docking results for complexes with AChE or BChE revealed that inhibitors 4, 7, and 15 stably positioned themselves in several pocket/catalytic domains of the AChE and BChE residues.

  20. Development and Benchmarking of a Hybrid PIC Code For Dense Plasmas and Fast Ignition

    Energy Technology Data Exchange (ETDEWEB)

    Witherspoon, F. Douglas [HyperV Technologies Corp.; Welch, Dale R. [Voss Scientific, LLC; Thompson, John R. [FAR-TECH, Inc.; MacFarlane, Joeseph J. [Prism Computational Sciences Inc.; Phillips, Michael W. [Advanced Energy Systems, Inc.; Bruner, Nicki [Voss Scientific, LLC; Mostrom, Chris [Voss Scientific, LLC; Thoma, Carsten [Voss Scientific, LLC; Clark, R. E. [Voss Scientific, LLC; Bogatu, Nick [FAR-TECH, Inc.; Kim, Jin-Soo [FAR-TECH, Inc.; Galkin, Sergei [FAR-TECH, Inc.; Golovkin, Igor E. [Prism Computational Sciences, Inc.; Woodruff, P. R. [Prism Computational Sciences, Inc.; Wu, Linchun [HyperV Technologies Corp.; Messer, Sarah J. [HyperV Technologies Corp.

    2014-05-20

    Computational Sciences, Inc. and Advanced Energy Systems Inc. joined efforts to develop new physics and numerical models for LSP in several key areas to enhance the ability of LSP to model high energy density plasmas (HEDP). This final report details those efforts. Areas addressed in this research effort include: adding radiation transport to LSP, first in 2D and then fully 3D, extending the EMHD model to 3D, implementing more advanced radiation and electrode plasma boundary conditions, and installing more efficient implicit numerical algorithms to speed complex 2-D and 3-D computations. The new capabilities allow modeling of the dominant processes in high energy density plasmas, and further assist the development and optimization of plasma jet accelerators, with particular attention to MHD instabilities and plasma/wall interaction (based on physical models for ion drag friction and ablation/erosion of the electrodes). In the first funding cycle we implemented a solver for the radiation diffusion equation. To solve this equation in 2-D, we used finite-differencing and applied the parallelized sparse-matrix solvers in the PETSc library (Argonne National Laboratory) to the resulting system of equations. A database of the necessary coefficients for materials of interest was assembled using the PROPACEOS and ATBASE codes from Prism. The model was benchmarked against Prism's 1-D radiation hydrodynamics code HELIOS, and against experimental data obtained from HyperV's separately funded plasma jet accelerator development program. Work in the second funding cycle focused on extending the radiation diffusion model to full 3-D, continued development of the EMHD model, optimizing the direct-implicit model to speed up calculations, add in multiply ionized atoms, and improved the way boundary conditions are handled in LSP. These new LSP capabilities were then used, along with analytic calculations and Mach2 runs, to investigate plasma jet merging, plasma detachment and transport

  1. Bio pics

    DEFF Research Database (Denmark)

    Nielsen, Jakob Isak

    2011-01-01

    Martin Zandvliets Dirch (2011) har ansporet til at skitsere den biografiske film som genre og knytte nogle kommentarer til dens forskellige udtryksmuligheder. Hovedeksemplerne er Walk the Line (2005) og I’m Not There (2007) om henholdsvis Johnny Cash og Bob Dylan....

  2. Bio pics

    DEFF Research Database (Denmark)

    Nielsen, Jakob Isak

    2011-01-01

    Martin Zandvliets Dirch (2011) har ansporet til at skitsere den biografiske film som genre og knytte nogle kommentarer til dens forskellige udtryksmuligheder. Hovedeksemplerne er Walk the Line (2005) og I’m Not There (2007) om henholdsvis Johnny Cash og Bob Dylan....

  3. PIC16F877单片机在Scorpion采集站中的应用%Application of PIC16F877 single chip computer in Scorpion acquisition unit

    Institute of Scientific and Technical Information of China (English)

    周阿群; 祝彩霞; 吴秀琴

    2012-01-01

    PIC is the prefixes of series single chip products, which are made in Microchip US. These single chips have the features of single system design and command in hard ware. This paper introduces the basic functions of PIC16F877 single chip and the working principle of Scorpion acquisition unit, then analyses the processes of PIC16F877 single chip in Scorpion acquisition unit in detail.%PIC是美国微芯科技公司(Microchip)生产的单片机系列产品型号的前缀,该系列单片机具有硬件系统设计简洁、指令系统精练等特点。本文在介绍PIC16F877单片机功能特点的基础上,结合Scorpion采集站的工作原理,对PIC16F877单片机在Scorpion采集站中的具体应用进行了详细分析。

  4. Spectral and Temporal Characteristics of LS PEG and TW PIC Using XMM-NEWTON Data

    Science.gov (United States)

    Talebpour Sheshvan, Nasrin; Balman, Solen

    2016-07-01

    We report the analysis of archival XMM-Newton X-ray observations of LS Peg and TW Pic. These are Cataclysmic Variables (CVs) suggested as Intermediate Polars (IPs), but unconfirmed in the X-rays. Identification of several periodic oscillations in the optical band hint them as IPs. Unlike the previous spectral analysis on the EPIC-MOS data by fitting a hot optically thin plasma emission model with a single temperature for LS Peg, we simultaneously fitted all EPIC spectrum (pn+MOS) using a composite model of absorption for interstellar medium (tbabs) with two different partial covering absorbers (pcfabs) including a multitemperature plasma emission component (cevmkl) and a Gaussian emission line at 6.4 keV. TW Pic is best modeled in a similar manner with only one partial covering absorber and an extra Gaussian emission line at 6.7 keV. LS Peg has a maximum plasma temperature of ˜14.8 keV with an X-ray luminosity of ˜5×10^{32}ergs ^{-1} translating to an accretion rate of ˜1.27×10^{-10}M _{⊙}yr ^{-1}. TW Pic shows kT _{max} ˜38.7 keV with an X-ray luminosity around 1.6×10^{33}ergs ^{-1} at an accretion rate of ˜4×10^{-10}M _{⊙}yr ^{-1}. In addition, we discuss orbital modulations in the X-rays and power spectral analysis, and derive the EPIC pn spectra for orbital minimum and orbital maximum phases for both sources. We elaborate on the geometry of accretion and absorption in the X-ray emitting regions of both sources with articulation on the magnetic nature.

  5. Far Ultraviolet Spectroscopy of Old Novae. II. RR Pic, V533 Her, and DI Lac

    Science.gov (United States)

    Sion, Edward M.; Godon, Patrick; Jones, Liam

    2017-03-01

    The old novae V533 Her (Nova Her 1963), DI Lac (Nova Lac 1910), and RR Pic (Nova Pic 1891) are in (or near) their quiescent stage, following their nova explosions, and continue to accrete at a high rate in the aftermath of their explosions. They exhibit continua that are steeply rising into the FUV, as well as absorption lines and emission lines of uncertain origin. All three have Far Ultraviolet Spectroscopic Explorer (FUSE) spectra that offer not only higher spectral resolution but also wavelength coverage extending down to the Lyman Limit. For DI Lac, we have matched these FUSE spectra with existing archival International Ultraviolet Explorer spectral coverage to broaden the FUV wavelength coverage. We adopted the newly determined interstellar reddening corrections of Selvelli & Gilmozzi. The dereddened FUV spectra have been modeled with our grids of optically thick accretion disks and hot, NLTE white dwarf (WD) photospheres. The results of our modeling analysis indicate that the hot components in RR Pic and V533 Her are likely to be accretion disks with mass accretion rates of 10‑8 M ⊙ yr‑1 and 10‑9 M ⊙ yr‑1 respectively. However, the disk cannot produce the observed absorption lines. For the WD to be the source of the absorption lines in these two systems, it must be very hot, with a radius several times its expected size (because the WD in these systems is massive, it has a smaller radius). For DI Lac, we find the best fit to be a disk with \\dot{M}={10}-10 {M}ȯ {{yr}}-1 with a 30,000 K WD. Based on observations made with the NASA-CNES-CSA Far Ultraviolet Spectroscopic Explorer (FUSE). FUSE was operated for NASA by the Johns Hopkins University under NASA contract NAS5-32985.

  6. PIC16F84 Microcontrollers Using the phone with the device to an Application Control

    OpenAIRE

    Yakar, Rahman; Etem KÖKLÜKAYA

    2017-01-01

    Bu çalışmada ev, işyeri vb. yerlerdekicihaziarın telefon vasıtası ile kontrol edilebilmesi içinPIC16F84 Mikrodenetleyici kullanılarak dizayndilen kontrol kartı devresi ile telefon hattının uygunşartlar altında açıiabilmesi için tasarlanan elektronikdevre gösterilmiş, aynca programın işleyişi açıklanmıştır.

  7. Comando e monitorização com PIC do conversor modulador bipolar

    OpenAIRE

    Santos, Nuno Gonçalo de Jesus dos

    2012-01-01

    O presente trabalho apresenta a análise, o projecto, a implementação e os ensaios de um protótipo de comando e monitorização dum conversor de potência, um gerador modulador bipolar, através de microcontroladores PIC. Foram desenvolvidos os circuitos de comando e respectivo protótipo, o circutiro de aquisição de sinal e o sftware para comandar e monitorizar o conversor modulador bipolar.

  8. Numerical Stability Improvements for the Pseudo-Spectral EM PIC Algorithm

    CERN Document Server

    Godfrey, Brendan B; Haber, Irving

    2013-01-01

    The pseudo-spectral analytical time-domain (PSATD) particle-in-cell (PIC) algorithm solves the vacuum Maxwell's equations exactly, has no Courant time-step limit (as conventionally defined), and offers substantial flexibility in plasma and particle beam simulations. It is, however, not free of the usual numerical instabilities, including the numerical Cherenkov instability, when applied to relativistic beam simulations. This paper presents several approaches that, when combined with digital filtering, almost completely eliminate the numerical Cherenkov instability. The paper also investigates the numerical stability of the PSATD algorithm at low beam energies.

  9. Application of PIC microcontrollers in single-sensor dual gas-CO/CH4 detectors

    Science.gov (United States)

    Pietraszek, Stanislaw; Pachole, Aleksander

    2001-08-01

    The main aim of this work is to present an application of PIC16 microcontrollers in single sensor two gas - CO and CH4 detectors, using recently developed by FIS Incorporated, semiconductor sensor SB-95. Microcontroller is used not only for comparison the actual output signal from the sensor with the warning and alarm thresholds, but also provides control and self diagnostic functions. Output logic signals allow user to check the level of gas concentration and detect the improper operation of sensor and electronics circuits.

  10. Three-Dimensional PIC-MC Modeling for Relativistic Electron Beam Transport Through Dense Plasma

    Institute of Scientific and Technical Information of China (English)

    CAO Lihua; CHANG Tieqiang; PEI Wenbing; LIU Zhanjun; LI Meng; ZHENG Chunyang

    2008-01-01

    We have developed a three dimensional (3D) PIC (particle-in-cell)-MC (Monte Carlo) code in order to simulate an electron beam transported into the dense matter based on our previous two dimensional code. The relativistic motion of fast electrons is treated by the particle-in-cell method under the influence of both a self-generated transverse magnetic field and an axial electric field, as well as collisions. The electric field generated by return current is ex-pressed by Ohm's law and the magnetic field is calculated from Faraday's law. The slowing down of monoenergy electrons in DT plasma is calculated and discussed.

  11. Modulador-Demodulador ASK con codificación Manchester implementado en un microcontrolador PIC

    Directory of Open Access Journals (Sweden)

    Ariel Tarifa Amaya

    2012-12-01

    Full Text Available Se presenta el diseño de un Modulador-Demodulador Digital ASK con codificación Manchester implementado en el firmware de un microcontrolador PIC 18F4455, utilizando el estándar de baja frecuencia (LF el cual maneja valores de 125kHz. Este modulador-demodulador se utiliza en la implementación de una etiqueta RFID activa. Transmite a solicitud de un dispositivo lector el valor de temperatura de un sensor y su identificador. El dispositivo lector, controla la comunicación con la etiqueta. Según la literatura especializada no se reporta un sistema similar.

  12. Cephaloleia sp. Cerca a Vagelineata Pic*, una Plaga de la Palma Africana

    Directory of Open Access Journals (Sweden)

    Urueta Sandino Eduardo

    1972-08-01

    Full Text Available Cephalolia sp. y Cephaloleila sp, se han empleado como sinónimos del género Cepaloleia sp. (Lepesme. 1947. Se sabe que los estados de larva y adulto atacan el follaje de la palma africana (Elaeis guineensis Jacq. trayendo muchas veces como consecuencia secamientos en los folíolos o su invasión por hongos. En Colombia el Cephaloleia próximo a vagelineata Pic se presenta en la zona de Urabá y posiblemente en el Departamento de Santander.

  13. Photon-counting chip-interleaved iterative PIC detector over atmospheric turbulence channels

    Institute of Scientific and Technical Information of China (English)

    Xiaolin Zhou; Yandong Yang; Yufeng Shao; Jun Liu

    2012-01-01

    A photon-counting-based iterative parallel interference cancellation (PIC) scheme for free-space optical communications in the presence of multiple-access interference,shot noise,background radiation,and turbulence fading is designed.An efficient chip-level iterative equivalent noise estimation algorithm is also derived.Simulation results show that the proposed scheme can achieve a single-user performance,bound with the fast convergence property.More importantly,it can eliminate the bit-error rate floor of the conventional optical code-division multiple-access system with the aid of a relatively short spreading code length.

  14. Introducción a los microcontroladores RISC en Lenguaje C. PIC's de Microchips

    Directory of Open Access Journals (Sweden)

    Tito Flórez C.

    2011-02-01

    Full Text Available A medida que el programa de los microcontroladores se hace más complejo, trabajar en lenguaje "assembler" se hace más dispendioso, dificil de manejar y el control de interrupciones muchas veces son un dolor de cabeza. Una muy buena alternativa para solucionar estos problemas, es usar el lenguaje C para programarlos. De esta forma, los programas se vuelven muy sencillos; lo mismo que el de iuterrupciones se convierte ahora en algo muy sencillo. Se presentan los elementos y las instrucciones más importantes para poder llegar a desarrollar un sin número de programas para los PICs.

  15. A new species of Falsopodabrus Pic characterized with geometric morphometrics (Coleoptera, Cantharidae).

    Science.gov (United States)

    Li, Limei; Qi, Yaqing; Yang, Yuxia; Bai, Ming

    2016-01-01

    A new species of Falsopodabrus Pic, 1927 is described, Falsopodabrus tridentatus Yang, sp. n. (Yunnan, China). Geometric morphometric analyses based on the shapes of pronotum and hind wing and comparisons with two sibling species, Falsopodabrus himalaicus Wittmer, 1974 and Falsopodabrus martensi (Wittmer, 1979), support the valid status of the new species, also confirmed by the characters of tarsal claws. In addition to Falsopodabrus himalaicus and Falsopodabrus martensi, Falsopodabrus kostali Švihla, 2004 and Falsopodabrus rolciki Švihla, 2004 are recorded from China for the first time.

  16. Towards the optimization of a gyrokinetic Particle-In-Cell (PIC) code on large-scale hybrid architectures

    Science.gov (United States)

    Ohana, N.; Jocksch, A.; Lanti, E.; Tran, T. M.; Brunner, S.; Gheller, C.; Hariri, F.; Villard, L.

    2016-11-01

    With the aim of enabling state-of-the-art gyrokinetic PIC codes to benefit from the performance of recent multithreaded devices, we developed an application from a platform called the “PIC-engine” [1, 2, 3] embedding simplified basic features of the PIC method. The application solves the gyrokinetic equations in a sheared plasma slab using B-spline finite elements up to fourth order to represent the self-consistent electrostatic field. Preliminary studies of the so-called Particle-In-Fourier (PIF) approach, which uses Fourier modes as basis functions in the periodic dimensions of the system instead of the real-space grid, show that this method can be faster than PIC for simulations with a small number of Fourier modes. Similarly to the PIC-engine, multiple levels of parallelism have been implemented using MPI+OpenMP [2] and MPI+OpenACC [1], the latter exploiting the computational power of GPUs without requiring complete code rewriting. It is shown that sorting particles [3] can lead to performance improvement by increasing data locality and vectorizing grid memory access. Weak scalability tests have been successfully run on the GPU-equipped Cray XC30 Piz Daint (at CSCS) up to 4,096 nodes. The reduced time-to-solution will enable more realistic and thus more computationally intensive simulations of turbulent transport in magnetic fusion devices.

  17. 3D PIC simulations of electron beams created via reflection of intense laser light from a water target

    CERN Document Server

    Ngirmang, Gregory K; Feister, Scott; Morrison, John T; Chowdhury, Enam A; Frische, Kyle; Roquemore, W M

    2015-01-01

    We present 3D Particle-in-Cell (PIC) modeling of an ultra-intense laser experiment by the Extreme Light group at the Air Force Research Laboratory (AFRL) using the PIC code LSP. This is the first time PIC simulations have been performed in 3D for this experiment which involves an ultra-intense, short-pulse (30 fs) laser interacting with a water jet target at normal incidence. These 3D PIC simulation results are compared to results from 2D(3$v$) PIC simulations for both $5.4\\cdot10^{17}$ W cm$^{-2}$ and $3\\cdot10^{18}$ W cm$^{-2}$ intensities. Comparing the 2D(3$v$) and 3D simulation results, the laser-energy-to-ejected-electron-energy conversion efficiencies were comparable, but the angular distribution of ejected electrons show interesting differences with qualitative differences at higher intensity. An analytic plane-wave model is provided that provides some explanation for the angular distribution and energies of ejected electrons in the 2D(3$v$) simulations. We also performed a 3D simulation with circular...

  18. Salient factors in the low utilization of PICS bags (triple-bagging in Nasarawa local government area of Kano state, Nigeria

    Directory of Open Access Journals (Sweden)

    A.J. Adegbola

    2013-03-01

    Full Text Available Thepaper asserts that cowpea is a major nutritional legume in West Africa and thatthe grain experiences great losses at postharvest stages especially at storage.It posits that hermetic storage which the PICS is one of have proved to be avery successful storage option for cowpea storage without the use of agrochemicals but that there are daunting problems with its utilization. The studyrevealed among others that having outlets where the PICS can be bought(29%,making the PICS cheaper (45%, convince grain merchants that the PICS is more effective than regular storagebags(19%, and lastly forcing it on grain merchants by government would lead to more usage of the PICS (7%. Basedon the opinion of the cowpea merchants it was recommended that the sellingprice of the PICS be reviewed downwards, and that there should be a massiveenlightenment campaign for the use of the PICS; advantages of the PICS overregular bags and how to use the PICS should be demonstrated in all grainmarkets in the region by extension bodies both public and private.

  19. Orbital Constraints on the (beta) Pic Inner Planet Candidate with Keck Adaptive Optics

    Energy Technology Data Exchange (ETDEWEB)

    Fitzgerald, M P; Kalas, P G; Graham, J R

    2009-09-23

    A point source observed 8AU in projection from {beta} Pictoris in L{prime} (3.8 {micro}m) imaging in 2003 has been recently presented as a planet candidate. Here we show the results of L{prime}-band adaptive optics imaging obtained at Keck Observatory in 2008. We do not detect {beta} Pic b beyond a limiting radius of 0.29-inch, or 5.5AU in projection, from the star. If {beta} Pic b is an orbiting planet, then it has moved {ge} 0.12-inch (2.4AU in projection) closer to the star in the five years separating the two epochs of observation. We examine the range of orbital parameters consistent with the observations, including likely bounds from the locations of previously inferred planetesimal belts. We find a family of low-eccentricity orbits with semimajor axes {approx} 8-9AU that are completely allowed, as well as a broad region of orbits with e {approx}< 0.2, a {approx}> 10AU that are allowed if the apparent motion of the planet was towards the star in 2003. We compare this allowed space with predictions of the planetary orbital elements from the literature. Additionally, we show how similar observations in the next several years can further constrain the space of allowed orbits. Non-detections of the source through 2013 will exclude the interpretation of the candidate as a planet orbiting between the 6.4 and 16AU planetesimal belts.

  20. 2D ArcPIC Code Description: Description of Methods and User / Developer Manual (second edition)

    CERN Document Server

    Sjobak, Kyrre Ness

    2014-01-01

    Vacuum discharges are one of the main limiting factors for future linear collider designs such as that of the Compact LInear Collider (CLIC). To optimize machine efficiency, maintaining the highest feasible accelerating gradient below a certain breakdown rate is desirable; understanding breakdowns can therefore help us to achieve this goal. As a part of ongoing theoretical research on vacuum discharges at the Helsinki Institute of Physics, the build-up of plasma can be investigated through the particle-in-cell method. For this purpose, we have developed the 2D ArcPIC code introduced here. We present an exhaustive description of the 2D ArcPIC code in several parts. In the first chapter, we introduce the particle-in-cell method in general and detail the techniques used in the code. In the second chapter, we describe the code and provide a documentation and derivation of the key equations occurring in it. In the third chapter, we describe utilities for running the code and analyzing the results. The last chapter...

  1. Preliminary investigations on 3D PIC simulation of DPHC structure using NEPTUNE3D code

    Science.gov (United States)

    Zhao, Hailong; Dong, Ye; Zhou, Haijing; Zou, Wenkang; Wang, Qiang

    2016-10-01

    Cubic region (34cm × 34cm × 18cm) including the double post-hole convolute (DPHC) structure was chosen to perform a series of fully 3D PIC simulations using NEPTUNE3D codes, massive data ( 200GB) could be acquired and solved in less than 5 hours. Cold-chamber tests were performed during which only cathode electron emission was considered without temperature rise or ion emission, current loss efficiency was estimated by comparisons between output magnetic field profiles with or without electron emission. PIC simulation results showed three stages of current transforming process with election emission in DPHC structure, the maximum ( 20%) current loss was 437kA at 15ns, while only 0.46% 0.48% was lost when driving current reached its peak. DPHC structure proved valuable functions during energy transform process in PTS facility, and NEPTUNE3D provided tools to explore this sophisticated physics. Project supported by the National Natural Science Foundation of China, Grant No. 11571293, 11505172.

  2. Implementation of PIC16F877A Based Intelligent Smart Home System

    Directory of Open Access Journals (Sweden)

    M Shanmugasundaram

    2013-04-01

    Full Text Available In recent years Intelligent Smart Home System has become one of the main applications of Wireless Sensor Networks. In this paper a low cost, low power smart home system using ZIGBEE, GSM, sensors (smoke, IR motion sensors and RFID has been presented. ZIGBEE is a new short distance, low data rate wireless network technology. It is built on the IEEE 802.15.4 low rate wireless Personal Area Network standard. PIC16F877A controller is used in a predominant way because it is rich in peripherals and hence many devices can be interfaced at ease, it is also very cheap and can be easily assembled and programmed. The PIC controller controls the devices and sends the sensor values to the PC via ZIGBEE module. Although Bluetooth is better than ZIGBEE for transmission rate, ZIGBEE has lower power consumption. Hence, ZIGBEE is generally used for 24 hours monitoring of communication transmission systems. At the PC terminal, LABVIEW is used to control the GSM and ZIGBEE operations. The system can detect fire and theft situations and reacts accordingly by turning on the buzzer and sending alert SMS through GSM module. This system also monitors the building occupants and saves the energy by switching off certain devices like fan and lights when the room is unoccupied.

  3. Comparison of scaling laws with PIC simulations for proton acceleration with long wavelength pulses

    Energy Technology Data Exchange (ETDEWEB)

    Turchetti, G., E-mail: turchetti@bo.infn.i [Dipartimento di Fisica Universita di Bologna, INFN Sezione di Bologna (Italy); Sgattoni, A.; Benedetti, C. [Dipartimento di Fisica Universita di Bologna, INFN Sezione di Bologna (Italy); Londrillo, P. [INFN Sezione di Bologna (Italy); Di Lucchio, L. [Dipartimento di Fisica Universita di Bologna, INFN Sezione di Bologna (Italy)

    2010-08-01

    We have performed a survey of proton acceleration induced by long wavelength pulses to explore their peak energy dependence on the pulse intensity, target thickness and density. The simulations carried out with the PIC code ALADYN for a circularly polarized pulse have been compared with the scaling laws for radiation pressure acceleration (RPA) in the thick target and thin target regimes known as hole boring (HB) and relativistic mirror (RM) respectively. Since the critical density scales as {lambda}{sup -2}, longer wavelength pulses allow to work with low density targets several microns thick and with moderate laser power. Under these conditions is possible to enter the RM region, where the key parameter is the ratio {alpha} between twice laser energy and the mirror rest energy; the corresponding acceleration efficiency is given by {alpha}/(1+{alpha}). For a fixed intensity the minimum thickness of the target, and consequently the highest acceleration, is determined by the threshold of self induced transparency. In this case the number of accelerated particles scales with {lambda} whereas the total energy does not depend on it. The agreement of PIC simulations with RPA and RM scalings, including the transition regions, suggests that these scalings can safely be used as the first step in the parametric scans also for large wavelength pulses such as CO{sub 2} lasers, to explore possible alternatives to short wavelength very high power Ti:Sa lasers for proton acceleration.

  4. PIC simulations of the MagnetoRotational instability in electron-positron plasmas

    Science.gov (United States)

    Inchingolo, Giannandrea; Grismayer, Thomas; Loureiro, Nuno F.; Fonseca, Ricardo A.; Silva, Luis O.

    2016-10-01

    The magnetorotational instability (MRI) is a crucial mechanism of angular momentum transport in a variety of astrophysical scenarios, as e-e+ plasmas accretion disks nearness neutron stars and black holes. The MRI has been widely studied using MHD models and simulations, in order to understand the behavior of astrophysical fluids in a state of differential rotation. When the timescale for electron and ion collisions is longer than the inflow time in the disk, the plasma is macroscopically collisionless and MHD breaks down. This is the case of the limit of weak magnetic field, i.e., as the ratio of the ion cyclotron frequency to orbital frequency becomes small. Leveraging on the recent addition of the shearing co-rotating frames equations of motion and Maxwell's equations modules in our PIC code OSIRIS 3.0, we intend to present our recent results of the analysis of MRI in electron-positron plasma in the limit of weak magnetic field. We will recall the theoretical 1D linear model of Krolik et Zweibel that describes the behavior of MRI in the limit of weak magnetic field and use it to support our results. Moving to 2D simulations, the analysis of MRI via PIC code permits to investigate also how MRI will act in comparison with other Kinetic instabilities, like mirror instability.

  5. PIC Simulations of the Effect of Velocity Space Instabilities on Electron Viscosity and Thermal Conduction

    CERN Document Server

    Riquelme, Mario; Verscharen, Daniel

    2016-01-01

    In low-collisionality plasmas, velocity-space instabilities are a key mechanism providing an effective collisionality for the plasma. We use particle-in-cell (PIC) simulations to study the interplay between electron and ion-scale velocity-space instabilities and their effect on electron pressure anisotropy, viscous heating, and thermal conduction. The adiabatic invariance of the magnetic moment in low-collisionality plasmas leads to pressure anisotropy, $p_{\\perp,j} > p_{||,j}$, if the magnetic field $\\vec{B}$ is amplified ($p_{\\perp,j}$ and $p_{||,j}$ denote the pressure of species $j$ [electron, ion] perpendicular and parallel to $\\vec{B}$). If the resulting anisotropy is large enough, it can in turn trigger small-scale plasma instabilities. Our PIC simulations explore the nonlinear regime of the mirror, ion-cyclotron, and electron whistler instabilities, through continuous amplification of the magnetic field $|\\vec{B}|$ by an imposed shear in the plasma. In the regime $1 \\lesssim \\beta_j \\lesssim 20$ ($\\be...

  6. PIC/MCC simulation of capacitively coupled discharges: Effect of particle management and integration

    Science.gov (United States)

    Sun, Anbang; Becker, Markus M.; Loffhagen, Detlef

    2016-09-01

    A PIC/MCC simulation model for the analysis of low-temperature discharge plasmas is represented which takes the common leapfrog and the velocity Verlet algorithm for the particle integration, adaptive particle management as well as parallel computing using MPI into account. Main features of the model including the impact of super particle numbers, adaptive particle management and the time step size for the different integration methods are represented. The investigations are performed for low-pressure capacitively coupled radio frequency discharges in helium and argon. Besides a code verification by comparison with benchmark simulation results in helium it is shown that an adaptive particle management is particularly suitable for the simulation of discharges at elevated pressures where boundary effects and processes in the sheath regions are important. Furthermore, it is pointed out that the velocity Verlet integration scheme allows to speed up the PIC/MCC simulations compared to the leapfrog method because it makes the use of larger time steps at the same accuracy possible.

  7. Investigating The Role of Temporal Smoothing in Circuit Models for PIC/DSMC Simulations

    Science.gov (United States)

    Moore, Stan; Hopkins, Matthew; Moore, Christopher

    2016-09-01

    Including a circuit model in PIC/DSMC simulations is essential for reproducing realistic electrical breakdown behavior. A commonly used circuit model for 1D simulations was developed by Verboncoeur et al.. Because PIC simulations use computational superparticles to represent many physical particles, severe noise in the measured current from particles can result, especially when using small timesteps. In the extreme case of timestep approaching zero, current measured by particles impacting a surface during a timestep becomes ill-defined without smoothing. In this talk, we investigate the effect of a noisy current on Verboncoeur's circuit model and test whether temporally smoothing quantities of interest can help improve the results. We also describe an alternative method of solving the circuit equations and compare to Verboncoeur's method. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

  8. Design and Construction of Load Sharing control system using PIC microcontroller

    Directory of Open Access Journals (Sweden)

    Nan Ei Ei Naing

    2014-03-01

    Full Text Available In this system, there are four power sources: Solar, Wind, Generator and Grid Line. Among them solar and wind are mainly used. When any two sources are not available or only one source is available, the grid line will be used. When the grid line also does not active, the generator will be turned on and can support to only one load. There are three kind of loads and can be organized as load-1 (10 lamps and 3 computers, load-2 (4 computers and load-3 (an air-con for power balance. Main aim for this work is to adjust between available power and consuming power automatically. To sense the input available sources power, voltage sensing circuit is used. The measurement data from the voltage sensing circuit is sent into the PIC microcontroller in which suitable algorithm will be done connecting with relays via relay driver circuit. For software implementation, visual basic programming language is used. To demonstrate the hardware implementation, PIC 18F4550 microcontroller, voltage sensing circuit and relay setting circuit are used.

  9. Tropospheric GOM at the Pic du Midi Observatory-Correcting Bias in Denuder Based Observations.

    Science.gov (United States)

    Marusczak, Nicolas; Sonke, Jeroen E; Fu, Xuewu; Jiskra, Martin

    2017-01-17

    Gaseous elemental mercury (GEM, Hg) emissions are transformed to divalent reactive Hg (RM) forms throughout the troposphere and stratosphere. RM is often operationally quantified as the sum of particle bound Hg (PBM) and gaseous oxidized Hg (GOM). The measurement of GOM and PBM is challenging and under mounting criticism. Here we intercompare six months of automated GOM and PBM measurements using a Tekran (TK) KCl-coated denuder and quartz regenerable particulate filter method (GOMTK, PBMTK, and RMTK) with RMCEM collected on cation exchange membranes (CEMs) at the high altitude Pic du Midi Observatory. We find that RMTK is systematically lower by a factor of 1.3 than RMCEM. We observe a significant relationship between GOMTK (but not PBMTK) and Tekran flushTK blanks suggesting significant loss (36%) of labile GOMTK from the denuder or inlet. Adding the flushTK blank to RMTK results in good agreement with RMCEM (slope = 1.01, r(2) = 0.90) suggesting we can correct bias in RMTK and GOMTK. We provide a bias corrected (*) Pic du Midi data set for 2012-2014 that shows GOM* and RM* levels in dry free tropospheric air of 198 ± 57 and 229 ± 58 pg m(-3) which agree well with in-flight observed RM and with model based GOM and RM estimates.

  10. pic gene of enteroaggregative Escherichia coli and its association with diarrhea in Peruvian children.

    Science.gov (United States)

    Durand, David; Contreras, Carmen A; Mosquito, Susan; Ruíz, Joaquim; Cleary, Thomas G; Ochoa, Theresa J

    2016-08-01

    Enteroaggregative Escherichia coli (EAEC) causes acute and persistent diarrhea among children, HIV-infected patients, and travelers to developing countries. We have searched for 18 genes-encoding virulence factors associated with aggregative adherence, dispersion, biofilm, toxins, serine protease autotransporters of Enterobacteriaceae (SPATEs) and siderophores, analyzed in 172 well-characterized EAEC strains (aggR(+)) isolated from stool samples of 97 children with diarrhea and 75 healthy controls from a passive surveillance diarrhea cohort study in Peru. Eighty-one different genetic profiles were identified, 37 were found only associated with diarrhea and 25 with control samples. The most frequent genetic profile was aggC(+)aatA(+)aap(+)shf(+)fyuA(+), present in 19 strains, including diarrhea and controls. The profile set1A(+)set1B(+)pic(+) was associated with diarrhea (P pic was associated with diarrhea (P < 0.05) and with prolonged diarrhea (diarrhea ≥ 7 days) (P < 0.05). In summary, this is the first report on the prevalence of a large set of EAEC virulence genes and its association with diarrhea in Peruvian children. More studies are needed to elucidate the exact role of each virulence factor.

  11. Recent advances in high-performance modeling of plasma-based acceleration using the full PIC method

    Science.gov (United States)

    Vay, J.-L.; Lehe, R.; Vincenti, H.; Godfrey, B. B.; Haber, I.; Lee, P.

    2016-09-01

    Numerical simulations have been critical in the recent rapid developments of plasma-based acceleration concepts. Among the various available numerical techniques, the particle-in-cell (PIC) approach is the method of choice for self-consistent simulations from first principles. The fundamentals of the PIC method were established decades ago, but improvements or variations are continuously being proposed. We report on several recent advances in PIC-related algorithms that are of interest for application to plasma-based accelerators, including (a) detailed analysis of the numerical Cherenkov instability and its remediation for the modeling of plasma accelerators in laboratory and Lorentz boosted frames, (b) analytic pseudo-spectral electromagnetic solvers in Cartesian and cylindrical (with azimuthal modes decomposition) geometries, and (c) novel analysis of Maxwell's solvers' stencil variation and truncation, in application to domain decomposition strategies and implementation of perfectly matched layers in high-order and pseudo-spectral solvers.

  12. Recent advances in high-performance modeling of plasma-based acceleration using the full PIC method

    Energy Technology Data Exchange (ETDEWEB)

    Vay, J.-L., E-mail: jlvay@lbl.gov [LBNL, Berkeley, CA 94720 (United States); Lehe, R. [LBNL, Berkeley, CA 94720 (United States); Vincenti, H. [CEA, Saclay (France); Godfrey, B.B. [LBNL, Berkeley, CA 94720 (United States); U. Maryland, College Park, MD 20742 (United States); Haber, I. [U. Maryland, College Park, MD 20742 (United States); Lee, P. [LPGP, CNRS, Université Paris-Saclay, 91405 Orsay (France)

    2016-09-01

    Numerical simulations have been critical in the recent rapid developments of plasma-based acceleration concepts. Among the various available numerical techniques, the particle-in-cell (PIC) approach is the method of choice for self-consistent simulations from first principles. The fundamentals of the PIC method were established decades ago, but improvements or variations are continuously being proposed. We report on several recent advances in PIC-related algorithms that are of interest for application to plasma-based accelerators, including (a) detailed analysis of the numerical Cherenkov instability and its remediation for the modeling of plasma accelerators in laboratory and Lorentz boosted frames, (b) analytic pseudo-spectral electromagnetic solvers in Cartesian and cylindrical (with azimuthal modes decomposition) geometries, and (c) novel analysis of Maxwell's solvers' stencil variation and truncation, in application to domain decomposition strategies and implementation of perfectly matched layers in high-order and pseudo-spectral solvers.

  13. Performance of the micro-PIC gaseous area detector in small-angle X-ray scattering experiments.

    Science.gov (United States)

    Hattori, Kaori; Tsuchiya, Ken'ichi; Ito, Kazuki; Okada, Yoko; Fujii, Kotaro; Kubo, Hidetoshi; Miuchi, Kentaro; Takata, Masaki; Tanimori, Toru; Uekusa, Hidehiro

    2009-03-01

    The application of a two-dimensional photon-counting detector based on a micro-pixel gas chamber (micro-PIC) to high-resolution small-angle X-ray scattering (SAXS), and its performance, are reported. The micro-PIC is a micro-pattern gaseous detector fabricated by printed circuit board technology. This article describes the performance of the micro-PIC in SAXS experiments at SPring-8. A dynamic range of >10(5) was obtained for X-ray scattering from a polystyrene sphere solution. A maximum counting rate of up to 5 MHz was observed with good linearity and without saturation. For a diffraction pattern of collagen, weak peaks were observed in the high-angle region in one accumulation of photons.

  14. Yeast extract and prebiotic in pre-initial phase diet for broiler chickens raised under different temperatures Extrato de leveduras e prebiótico na dieta pré-inicial de frangos de corte criados em diferentes temperaturas

    Directory of Open Access Journals (Sweden)

    Vanessa Karla Silva

    2010-01-01

    Full Text Available The objective of this research was to evaluate the performance, carcass yield and intestinal morphometry of broiler chickens raised under different temperatures that received feed with or without yeast extract and prebiotic in the pre-initial phase. One thousand four hundred and forty one-day old male chicks were used, raised in different climate chambers. Feed with or without the addition of yeast extract and prebiotic was offered only in the pre-initial phase (1 to 7 days. From the eighth day on, every chick received the same feed, readjusted according to usual recommendations. A randomized complete experimental design was used in a 3 × 2 × 2 factorial arrangement, consisting of three environmental temperatures (hot, comfort and cold and two levels of yeast extract (with or without and prebiotic (with or without. The performance of the birds was evaluated considering weight gain, feed intake, food conversion and viability at 42 days of age. Carcass yield and intestinal morphometry were also evaluated. Environmental heat impaired performance and carcass yield. Prebiotic inclusion in the pre-initial feed increased weight gain and enhanced food conversion of birds raised under hot conditions. The inclusion of products in the feed of broiler chickens raised in hot and cold environments has beneficial effects on chicken intestinal villi.Objetivou-se nesta pesquisa avaliar o desempenho, o rendimento de carcaça e a morfometria intestinal de frangos de corte criados em diferentes temperaturas e que receberam na fase pré-inicial ração contendo ou não extrato de leveduras e prebiótico. Foram utilizados 1.440 pintos machos de 1 dia de idade, criados em diferentes câmaras climáticas. As rações, acrescidas ou não de extrato de leveduras e prebiótico, foram oferecidas somente na fase pré-inicial (1 a 7 dias. A partir do oitavo dia, todas as aves receberam a mesma ração, reajustada de acordo com as recomendações usuais. Adotou-se o

  15. Identification of host proteins associated with HIV-1 preintegration complexes isolated from infected CD4+ cells.

    Science.gov (United States)

    Raghavendra, Nidhanapati K; Shkriabai, Nikolozi; Graham, Robert Lj; Hess, Sonja; Kvaratskhelia, Mamuka; Wu, Li

    2010-08-11

    An integrated HIV-1 genomic DNA leads to an infected cell becoming either an active or a latent virus-producing cell. Upon appropriate activation, a latently infected cell can result in production of progeny viruses that spread the infection to uninfected cells. The host proteins influence several steps of HIV-1 infection including formation of the preintegration complex (PIC), a key nucleoprotein intermediate essential for integration of reverse transcribed viral DNA into the chromosome. Much effort has gone into the identification of host proteins contributing to the assembly of functional PICs. Experimental approaches included the use of yeast two-hybrid system, co-immunoprecipitation, affinity tagged HIV-1 viral proteins and in vitro reconstitution of salt-stripped PIC activity. Several host proteins identified using these approaches have been shown to affect HIV-1 replication in cells and influence catalytic activities of recombinant IN in vitro. However, the comprehensive identification and characterization of host proteins associated with HIV-1 PICs of infected cells have been hindered in part by the technical limitation in acquiring sufficient amount of catalytically active PICs. To efficiently identify additional host factors associated with PICs in infected cells, we have developed the following novel approach. The catalytically active PICs from HIV-1-infected CD4+ cells were isolated using biotinylated target DNA, and the proteins selectively co-purifying with PICs have been analyzed by mass spectrometry. This technology enabled us to reveal at least 19 host proteins that are associated with HIV-1 PICs, of which 18 proteins have not been described previously with respect to HIV-1 integration. Physiological functions of the identified proteins range from chromatin organization to protein transport. A detailed characterization of these host proteins could provide new insights into the mechanism of HIV-1 integration and uncover new antiviral targets to

  16. Sine wave dimming circuit based on PIC16 MCU%基于PIC16单片机的正弦调光电路

    Institute of Scientific and Technical Information of China (English)

    戚伟; 邱旭伟; 刘劲松; 庞文尧; 肖铎

    2014-01-01

    针对可控硅调光对电网产生干扰以及斩控型正弦调光电路成本较高的问题,提出了一种低成本的间接型正弦调光电路.系统由全桥整流滤波电路以及全桥逆变电路组成,由PIC 16单片机软件产生双极性SPWM波的控制信号.实际制作了电路,并在400W高压钠灯感性负载上进行了测试,实现了灯光亮度的连续调节,且输出电压保持为无畸变的正弦波形.该系统有望取代现有的可控硅调压节电系统,对节能降耗工程起到推动作用.

  17. 基于PIC16F946的CO气体检测仪%Design of CO Gas Detection Instrument Based on PIC16F946

    Institute of Scientific and Technical Information of China (English)

    史军刚; 白小平; 郭瑞玺

    2007-01-01

    介绍了一种便携式CO气体检测仪的开发,论述了仪器的硬件原理图、一氧化碳气体传感器的参数模型分析以及软件的程序流程图,该仪器可实现检测空气中CO的含量,并可自动进行声、光以及震动报警,可通过按键设定二级报警值,并且可以对仪器进行标定,仪器以美国microchip公司的微控制器PIC16F946作为核心控制单元,分辨率为lppm;误差为士3%,采用3V的锂电池可以连续工作9000h以上,可广泛用于工业生产、环保、汽车、家庭等一氧化碳泄漏和不完全燃烧的检测报警.

  18. Synthesis, Characterization, and Structural Assessment of Ni(II Complexes Derived from Bis(2-hydroxy-1-naphthaldehydesuccinoyldihydrazone

    Directory of Open Access Journals (Sweden)

    Mithun Chakrabarty

    2015-01-01

    Full Text Available The monometallic nickel(II complexes [Ni(H2nsh(A2]·nH2O (where A = water (H2O, n=0 (1; pyridine (py, n=2 (2; 2-picoline(2-pic, n=0 (3; 3-picoline(3-pic, n=2 (4; and 4-picoline(4-pic, n=0 (5 and homobimetallic nickel(II complexes [Ni2(nsh(A4]·nH2O (where A = water (H2O, n=1 (6; pyridine (py, n=4 (7; 2-picoline(2-pic, n=4 (8; 3-picoline(3-pic, n=4 (9; and 4-picoline(4-pic, n=4 (10, resp. have been synthesized in methanol from bis(2-hydroxy-1-naphthaldehydesuccinoyldihydrazone (H4nsh. The complexes have been characterized by elemental analyses, molar conductance, magnetic moment, and electronic and IR and TGA/DTA spectroscopic studies. The monometallic complexes (1 to (5 are found to have octahedral stereochemistry while complexes (6 to (10 are found to have distorted octahedral stereochemistry in which one of the Ni(II centres is present in N2O2 coordination sphere and another Ni(II centre is bonded to it through phenolate oxygen atoms via oxo-bridging.

  19. Efficient silicon PIC mode multiplexer using grating coupler array with aluminum mirror for few-mode fiber

    DEFF Research Database (Denmark)

    Ding, Yunhong; Yvind, Kresten

    2015-01-01

    We demonstrate a silicon PIC mode multiplexer using grating couplers. An aluminum mirror is introduced for coupling efficiency improvement. A highest coupling efficiency of –10.6 dB with 3.7 dB mode dependent coupling loss is achieved.......We demonstrate a silicon PIC mode multiplexer using grating couplers. An aluminum mirror is introduced for coupling efficiency improvement. A highest coupling efficiency of –10.6 dB with 3.7 dB mode dependent coupling loss is achieved....

  20. Analysis of the beam halo in negative ion sources by using 3D3V PIC code

    Energy Technology Data Exchange (ETDEWEB)

    Miyamoto, K., E-mail: kmiyamot@naruto-u.ac.jp [Naruto University of Education, 748 Nakashima, Takashima, Naruto-cho, Naruto-shi, Tokushima 772-8502 (Japan); Nishioka, S.; Goto, I.; Hatayama, A. [Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522 (Japan); Hanada, M.; Kojima, A.; Hiratsuka, J. [Japan Atomic Energy Agency, 801-1 Mukouyama, Naka 319-0913 (Japan)

    2016-02-15

    The physical mechanism of the formation of the negative ion beam halo and the heat loads of the multi-stage acceleration grids are investigated with the 3D PIC (particle in cell) simulation. The following physical mechanism of the beam halo formation is verified: The beam core and the halo consist of the negative ions extracted from the center and the periphery of the meniscus, respectively. This difference of negative ion extraction location results in a geometrical aberration. Furthermore, it is shown that the heat loads on the first acceleration grid and the second acceleration grid are quantitatively improved compared with those for the 2D PIC simulation result.

  1. Analysis of the beam halo in negative ion sources by using 3D3V PIC code.

    Science.gov (United States)

    Miyamoto, K; Nishioka, S; Goto, I; Hatayama, A; Hanada, M; Kojima, A; Hiratsuka, J

    2016-02-01

    The physical mechanism of the formation of the negative ion beam halo and the heat loads of the multi-stage acceleration grids are investigated with the 3D PIC (particle in cell) simulation. The following physical mechanism of the beam halo formation is verified: The beam core and the halo consist of the negative ions extracted from the center and the periphery of the meniscus, respectively. This difference of negative ion extraction location results in a geometrical aberration. Furthermore, it is shown that the heat loads on the first acceleration grid and the second acceleration grid are quantitatively improved compared with those for the 2D PIC simulation result.

  2. Characterization of a trinuclear ruthenium species in catalytic water oxidation by Ru(bda)(pic)2 in neutral media.

    Science.gov (United States)

    Zhang, Biaobiao; Li, Fei; Zhang, Rong; Ma, Chengbing; Chen, Lin; Sun, Licheng

    2016-06-30

    A Ru(III)-O-Ru(IV)-O-Ru(III) type trinuclear species was crystallographically characterized in water oxidation by Ru(bda)(pic)2 (H2bda = 2,2'-bipyridine-6,6'-dicarboxylic acid; pic = 4-picoline) under neutral conditions. The formation of a ruthenium trimer due to the reaction of Ru(IV)[double bond, length as m-dash]O with Ru(II)-OH2 was fully confirmed by chemical, electrochemical and photochemical methods. Since the oxidation of the trimer was proposed to lead to catalyst decomposition, the photocatalytic water oxidation activity was rationally improved by the suppression of the formation of the trimer.

  3. Design, Modeling and Implementation of Pic Based Wireless Control System to Eliminate Blind Spots in Vehicle Side Mirrors

    Directory of Open Access Journals (Sweden)

    Mahmoud Z. Iskandarani

    2008-01-01

    Full Text Available A PIC controlled IR system for the control of vehicle side mirror system movements for the purpose of revealing blind spots is designed and implemented. The designed and built system allows the side view mirrors to be adjusted based on the driver head movement. The infrared-based head tracking system maps a predetermined coordinates for head movements and results in a triangularly computable geometry, which is fed to the PIC, based controlling system. This will cause the vehicle mirror movement via carefully selected miniature motors.

  4. ASIC or PIC? Implantable stimulators based on semi-custom CMOS technology or low-power microcontroller architecture.

    Science.gov (United States)

    Salmons, S; Gunning, G T; Taylor, I; Grainger, S R; Hitchings, D J; Blackhurst, J; Jarvis, J C

    2001-01-01

    To gain a better understanding of the effects of chronic stimulation on mammalian muscles we needed to generate patterns of greater variety and complexity than simple constant-frequency or burst patterns. We describe here two approaches to the design of implantable neuromuscular stimulators that can satisfy these requirements. Devices of both types were developed and used in long-term experiments. The first device was based on a semi-custom Application Specific Integrated Circuit (ASIC). This approach has the advantage that the circuit can be completely tested at every stage of development and production, assuring a high degree of reliability. It has the drawback of inflexibility: the patterns are produced by state machines implemented in silicon, so each new set of patterns requires a fresh production run, which is costly and time-consuming. The second device was based on a commercial microcontroller (Microchip PIC16C84). The functionality of this type of circuit is specified in software rather than in silicon hardware, allowing a single device to be programmed for different functions. With the use of features designed to improve fault-tolerance we found this approach to be as reliable as that based on ASICs. The encapsulated devices can easily be accommodated subcutaneously on the flank of a rabbit and a recent version is small enough to implant into the peritoneal cavity of rats. The current devices are programmed with a predetermined set of 12 patterns before assembly; the desired pattern is selected after implantation with an electronic flash gun. The operating current drain is less than 40 microA.

  5. Grafting and Paladin Pic-21 for Nematode and Weed Management in Vegetable Production

    Science.gov (United States)

    Kokalis-Burelle, Nancy; Butler, David M.; Hong, Jason C.; Bausher, Michael G.; McCollum, Greg; Rosskopf, Erin N.

    2016-01-01

    Two years of field trials conducted in a Meloidogyne incognita-infested field evaluated grafting and Paladin Pic-21 (dimethyl disulfide:chloropicrin [DMDS:Pic] 79:21) for root-knot nematode and weed control in tomato and melon. Tomato rootstocks evaluated were; ‘TX301’, ‘Multifort’, and ‘Aloha’. ‘Florida 47’ was the scion and the nongrafted control. A double crop of melon was planted into existing beds following tomato harvest. Melon rootstocks, C. metulifer and ‘Tetsukabuto’, were evaluated with nongrafted ‘Athena’ in year 1. In year 2, watermelon followed tomato with scion variety ‘Tri-X Palomar’ as the control and also grafted onto ‘Emphasis’ and ‘Strongtosa’ rootstocks. Four soil treatments were applied in fall both years under Canslit metalized film; Paladin Pic-21, methyl bromide:chloropicrin (MeBr:C33, 67:33), Midas (iodomethane:chloropicrin 50:50), and a herbicide-treated control. M. incognita J2 in soil were highest in herbicide control plots and nongrafted tomato. All soil treatments produced similar tomato growth, which was greater than the herbicide control. All treatments reduced M. incognita J2 in roots compared to the herbicide control. ‘Multifort’ rootstock produced the largest and healthiest roots; however, the number of M. incognita isolated from roots did not differ among the tomato rootstocks tested. Galling on tomato was highest in herbicide control plots and nongrafted plants. In melon, M. incognita J2 in soil did not differ among melon rootstocks, but numbers isolated from melon rootstocks increased in ‘Tetsukabuto’ compared with C. metuliferus. ‘Tetsukabuto’ were larger root systems than nongrafted ‘Athena’. All fumigants provided protection for all melon rootstocks against galling by M. incognita compared to the herbicide control. Galling on C. metuliferus rootstock was less in all fumigant treatments compared with nongrafted ‘Athena’ and ‘Tetsukabuto’. In watermelon, M. incognita

  6. Grafting and Paladin Pic-21 for Nematode and Weed Management in Vegetable Production.

    Science.gov (United States)

    Kokalis-Burelle, Nancy; Butler, David M; Hong, Jason C; Bausher, Michael G; McCollum, Greg; Rosskopf, Erin N

    2016-12-01

    Two years of field trials conducted in a Meloidogyne incognita-infested field evaluated grafting and Paladin Pic-21 (dimethyl disulfide:chloropicrin [DMDS:Pic] 79:21) for root-knot nematode and weed control in tomato and melon. Tomato rootstocks evaluated were; 'TX301', 'Multifort', and 'Aloha'. 'Florida 47' was the scion and the nongrafted control. A double crop of melon was planted into existing beds following tomato harvest. Melon rootstocks, C. metulifer and 'Tetsukabuto', were evaluated with nongrafted 'Athena' in year 1. In year 2, watermelon followed tomato with scion variety 'Tri-X Palomar' as the control and also grafted onto 'Emphasis' and 'Strongtosa' rootstocks. Four soil treatments were applied in fall both years under Canslit metalized film; Paladin Pic-21, methyl bromide:chloropicrin (MeBr:C33, 67:33), Midas (iodomethane:chloropicrin 50:50), and a herbicide-treated control. M. incognita J2 in soil were highest in herbicide control plots and nongrafted tomato. All soil treatments produced similar tomato growth, which was greater than the herbicide control. All treatments reduced M. incognita J2 in roots compared to the herbicide control. 'Multifort' rootstock produced the largest and healthiest roots; however, the number of M. incognita isolated from roots did not differ among the tomato rootstocks tested. Galling on tomato was highest in herbicide control plots and nongrafted plants. In melon, M. incognita J2 in soil did not differ among melon rootstocks, but numbers isolated from melon rootstocks increased in 'Tetsukabuto' compared with C. metuliferus. 'Tetsukabuto' were larger root systems than nongrafted 'Athena'. All fumigants provided protection for all melon rootstocks against galling by M. incognita compared to the herbicide control. Galling on C. metuliferus rootstock was less in all fumigant treatments compared with nongrafted 'Athena' and 'Tetsukabuto'. In watermelon, M. incognita in soil and roots did not differ among soil treatments or

  7. 基于dsPIC30F3011的飞轮电池控制系统设计%Design of Control System of Flywheel Battery Based on dsPIC30F3011

    Institute of Scientific and Technical Information of China (English)

    王兴贵; 何翼; 孙晓静

    2011-01-01

    The paper proposed a design scheme of control system of flywheel battery based on dsPIC30F3011 according to charge-discharge process of flywheel battery. It gave structure and control principle of the system and introduced design of hardware and software of the system in details. The debugging result showed that the system fully makes use of high-speed calculating ability and rich chip peripheral resources of dsPIC30F3011, and makes flywheel battery not only has good steady characteristics but also higher dynamic quality in energy storage process.%根据飞轮电池充放电过程的特点,提出了一种基于dsPIC30F3011的飞轮电池控制系统的设计万案;给出了该系统的结构及控制原理,详细介绍了该系统的硬件及软件设计.调试结果表明,该系统充分利用了dsPIC30F3011的高速运算能力和丰富的片内外设资源,使得飞轮电池储能过程不仅具有良好的稳态特性,而且具有较高的动态品质.

  8. Speed Digital Control of Brushless DC Motor Using dsPIC Controller

    Directory of Open Access Journals (Sweden)

    Gheorghe Băluţă

    2014-09-01

    Full Text Available This paper presents the digital control of the Brushless DC motor (BLDCM speed. The dsPICDEM MC1 development system (with the dsPIC30F6010A microcontroller and the dsPICDEM MC1L power module, manufactured by Microchip Company, were used. The control program was developed in C programming language. The graphical user interface was realized in LabVIEW 8.6 graphical programming language. For speed control, a digital controller PI type was implemented. Due to digital controller well chosen and well tuned, the system response at speed step variation is very good. Therewith, the experimental results obtained also show a good compensation of disturbance which does not happen in open-loop control.

  9. Envelope Detector Development for BFSK signals in PIC18f4550

    Directory of Open Access Journals (Sweden)

    Karel Toledo de la Garza

    2013-11-01

    Full Text Available This paper concerns demodulator-based Envelope Detector for recovery information in BFSK (Binary Frequency Shift Keying signal applied upon applications where time symbol synchronization is unknown. Its structure is characterized by 4 filters which are considered in the present article by FIR (Finite Impulse Response, these are unconditionally stables and are always implemented by the same generic difference equation. Towards validating the demodulator, the system is implemented on a Microchip PIC18F4550 interfaced to the PC through USB port, besides in order to manage the system’s operation, it is developed a Matlab application on PC that includes modulation frequency estimation by Fast Fourier Transform method, as well as sending and receiving the modulated and demodulated signals. The convolution between the input samples and the filter coefficients is made in the microcontroller by relying on two tables stored in memory which

  10. Numerical instability due to relativistic plasma drift in EM-PIC simulations

    CERN Document Server

    Xu, Xinlu; Martins, Samual F; Tsung, Frank S; Decyk, Viktor K; Fonseca, Ricardo A; Lu, Wei; Silva, Luis O; Mori, Warren B

    2012-01-01

    The numerical instability observed in the Electromagnetic-Particle-in-cell (EM-PIC) simulations with a plasma drifting with relativistic velocities is studied using both theory and computer simulations. We derive the numerical dispersion relation for a cold plasma drifting with a relativistic velocity and find an instability attributed to the coupling between the beam modes of the drifting plasma and the electromagnetic modes in the system. The characteristic pattern of the instability in Fourier space for various simulation setups and Maxwell Equation solvers are explored by solving the corresponding numerical dispersion relations. Furthermore, based upon these characteristic patterns we derive an asymptotic expression for the instability growth rate. The results are compared against simulation results and good agreement is found. The results are used as a guide to develop possible approaches to mitigate the instability. We examine the use of a spectral solver and show that such a solver when combined with a...

  11. Parametric instabilities of large-amplitude parallel propagating Alfven waves: 2-D PIC simulation

    CERN Document Server

    Nariyuki, Yasuhiro; Hada, Tohru

    2008-01-01

    We discuss the parametric instabilities of large-amplitude parallel propagating Alfven waves using the 2-D PIC simulation code. First, we confirmed the results in the past study [Sakai et al, 2005] that the electrons are heated due to the modified two stream instability and that the ions are heated by the parallel propagating ion acoustic waves. However, although the past study argued that such parallel propagating longitudinal waves are excited by transverse modulation of parent Alfven wave, we consider these waves are more likely to be generated by the usual, parallel decay instability. Further, we performed other simulation runs with different polarization of the parent Alfven waves or the different ion thermal velocity. Numerical results suggest that the electron heating by the modified two stream instability due to the large amplitude Alfven waves is unimportant with most parameter sets.

  12. Automatic Color Sorting Machine Using TCS230 Color Sensor And PIC Microcontroller

    Directory of Open Access Journals (Sweden)

    Kunhimohammed C K

    2015-12-01

    Full Text Available Sorting of products is a very difficult industrial process. Continuous manual sorting creates consistency issues. This paper describes a working prototype designed for automatic sorting of objects based on the color. TCS230 sensor was used to detect the color of the product and the PIC16F628A microcontroller was used to control the overall process. The identification of the color is based on the frequency analysis of the output of TCS230 sensor. Two conveyor belts were used, each controlled by separate DC motors. The first belt is for placing the product to be analyzed by the color sensor, and the second belt is for moving the container, having separated compartments, in order to separate the products. The experimental results promise that the prototype will fulfill the needs for higher production and precise quality in the field of automation.

  13. Theoretical benchmarking of laser-accelerated ion fluxes by 2D-PIC simulations

    CERN Document Server

    Mackenroth, Felix; Marklund, Mattias

    2016-01-01

    There currently exists a number of different schemes for laser based ion acceleration in the literature. Some of these schemes are also partly overlapping, making a clear distinction between the schemes difficult in certain parameter regimes. Here, we provide a systematic numerical comparison between the following schemes and their analytical models: light-sail acceleration, Coulomb explosions, hole boring acceleration, and target normal sheath acceleration (TNSA). We study realistic laser parameters and various different target designs, each optimized for one of the acceleration schemes, respectively. As a means of comparing the schemes, we compute the ion current density generated at different laser powers, using two-dimensional particle-in-cell (PIC) simulations, and benchmark the particular analytical models for the corresponding schemes against the numerical results. Finally, we discuss the consequences for attaining high fluxes through the studied laser ion-acceleration schemes.

  14. Neutron imaging detector based on the muPIC micro-pixel chamber

    CERN Document Server

    Parker, J D; Fujioka, H; Harada, M; Iwaki, S; Kabuki, S; Kishimoto, Y; Kubo, H; Kurosawa, S; Miuchi, K; Nagae, T; Nishimura, H; Oku, T; Sawano, T; Shinohara, T; Suzuki, J; Takada, A; Tanimori, T; Ueno, K

    2012-01-01

    We have developed a prototype time-resolved neutron imaging detector employing the micro-pixel chamber (muPIC), a micro-pattern gaseous detector, coupled with a field programmable gate array-based data acquisition system for applications in neutron radiography at high-intensity neutron sources. The prototype system, with an active area of 10cm x 10cm and operated at a gas pressure of 2 atm, measures both the energy deposition (via time-over-threshold) and 3-dimensional track of each neutron-induced event, allowing the reconstruction of the neutron interaction point with improved accuracy. Using a simple position reconstruction algorithm, a spatial resolution of 349 +/- 36 microns was achieved, with further improvement expected. The detailed tracking allows strong rejection of background gamma-rays, resulting in an effective gamma sensitivity of 10^-12 or less, coupled with stable, robust neutron identification. The detector also features a time resolution of 0.6 microseconds.

  15. LA UNIVERSIDAD ANTE LOS NUEVOS PARADIGMAS DE LA INFORMACIÓN Y EL CONOCIMIENTO (PIC)

    OpenAIRE

    2015-01-01

    En este artículo se hace un análisis teórico del comportamiento que deberían asumir las universidades, su gerencia y sus actores principales (docentes y estudiantes) ante el surgimiento de nuevos paradigmas de la información y el conocimiento (PIC) causados por la aprehensión de las tecnologías de información y comunicación (TIC). Se tomó como base la definición de la universidad del siglo XXI bajo la dimensión tecnológica de una sociedad sustentada en el conocimiento, cuyo pilar fundament...

  16. GPU-Accelerated PIC/MCC Simulation of Laser-Plasma Interaction Using BUMBLEBEE

    Science.gov (United States)

    Jin, Xiaolin; Huang, Tao; Chen, Wenlong; Wu, Huidong; Tang, Maowen; Li, Bin

    2015-11-01

    The research of laser-plasma interaction in its wide applications relies on the use of advanced numerical simulation tools to achieve high performance operation while reducing computational time and cost. BUMBLEBEE has been developed to be a fast simulation tool used in the research of laser-plasma interactions. BUMBLEBEE uses a 1D3V electromagnetic PIC/MCC algorithm that is accelerated by using high performance Graphics Processing Unit (GPU) hardware. BUMBLEBEE includes a friendly user-interface module and four physics simulators. The user-interface provides a powerful solid-modeling front end and graphical and computational post processing functionality. The solver of BUMBLEBEE has four modules for now, which are used to simulate the field ionization, electron collisional ionization, binary coulomb collision and laser-plasma interaction processes. The ionization characteristics of laser-neutral interaction and the generation of high-energy electrons have been analyzed by using BUMBLEBEE for validation.

  17. LA UNIVERSIDAD ANTE LOS NUEVOS PARADIGMAS DE LA INFORMACIÓN Y EL CONOCIMIENTO (PIC)

    OpenAIRE

    Edgar Chirinos; Carlos Figueredo A.; Aurora Goyo; Elita Méndez; Luís Rodolfo Rojas Vera

    2009-01-01

    En este artículo se hace un análisis teórico del comportamiento que deberían asumir las universidades, su gerencia y sus actores principales (docentes y estudiantes) ante el surgimiento de nuevos paradigmas de la información y el conocimiento (PIC) causados por la aprehensión de las tecnologías de información y comunicación (TIC). Se tomó como base la definición de la universidad del siglo XXI bajo la dimensión tecnológica de una sociedad sustentada en el conocimiento, cuyo pilar fundament...

  18. Development and Test of 2.5-Dimensional Electromagnetic PIC Simulation Code

    Science.gov (United States)

    Lee, Sang-Yun; Lee, Ensang; Kim, Khan-Hyuk; Seon, Jongho; Lee, Dong-Hun; Ryu, Kwang-Sun

    2015-03-01

    We have developed a 2.5-dimensional electromagnetic particle simulation code using the particle-in-cell (PIC) method to investigate electromagnetic phenomena that occur in space plasmas. Our code is based on the leap-frog method and the centered difference method for integration and differentiation of the governing equations. We adopted the relativistic Buneman-Boris method to solve the Lorentz force equation and the Esirkepov method to calculate the current density while maintaining charge conservation. Using the developed code, we performed test simulations for electron two-stream instability and electron temperature anisotropy induced instability with the same initial parameters as used in previously reported studies. The test simulation results are almost identical with those of the previous papers.

  19. QED-PIC simulations of electromagnetic cascades at the surface of pulsar's polar cap

    Science.gov (United States)

    Grismayer, Thomas; Vranic, Marija; Fonseca, Ricardo; Silva, Luis

    2016-10-01

    The recent implementation of the QED module in the OSIRIS 3.0 framework has enabled to simulate various scenarios where pair production or gamma-rays emission can be produced with ultra-intense lasers and/or relativistic particles beams. In this study we leverage on these numerical tools to study extreme astrophysical scenarios where self-consistent produced electron-positron pair plasmas are of relevance such as in pulsar magnetospheres. The dynamics of pulsar's polar cap cascade, based on the Ruderman-Sutherland model, has been investigated for the first time numerically in one dimension by Timokhin. Including quantum synchrotron radiation additionally to curvature photon radiation for the possible processes responsible for photon emission, we present the results of one and two dimensional QED-PIC simulations of the development of electromagnetic cascades at the surface of the polar cap and the subsequent plasma discharges that are accompanied by strong electrostatic waves.

  20. PIC simulation of a thermal anisotropy-driven Weibel instability in a circular rarefaction wave

    CERN Document Server

    Dieckmann, M E; Murphy, G C; Bret, A; Romagnani, L; Kourakis, I; Borghesi, M; Ynnerman, A; Drury, L O'C; 10.1088/1367-2630/14/2/023007

    2012-01-01

    The expansion of an initially unmagnetized planar rarefaction wave has recently been shown to trigger a thermal anisotropy-driven Weibel instability (TAWI), which can generate magnetic fields from noise levels. It is examined here if the TAWI can also grow in a curved rarefaction wave. The expansion of an initially unmagnetized circular plasma cloud, which consists of protons and hot electrons, into a vacuum is modelled for this purpose with a two-dimensional particle-in-cell (PIC) simulation. It is shown that the momentum transfer from the electrons to the radially accelerating protons can indeed trigger a TAWI. Radial current channels form and the aperiodic growth of a magnetowave is observed, which has a magnetic field that is oriented orthogonal to the simulation plane. The induced electric field implies that the electron density gradient is no longer parallel to the electric field. Evidence is presented here for that this electric field modification triggers a second magnetic instability, which results i...

  1. Particle-in-cell (PIC) simulations of beam instabilities in gyrotron beam tunnels

    Energy Technology Data Exchange (ETDEWEB)

    Tran, T.M.; Jost, G.; Appert, K.; Sauter, O. [Ecole Polytechnique Federale, Lausanne (Switzerland). Centre de Recherche en Physique des Plasma (CRPP); Wuthrich, S. [CRAY Research, PATP/PSE, Ecole Polytechnique Federale, Lausanne (Switzerland)

    1995-10-01

    Experimental observations seem to indicate that the beam velocity and energy spreads are larger than those calculated from the electron trajectory codes which do not take into account the effects of beam instabilities. On the other hand, parasitic oscillations of the beam with frequencies close to the electron cyclotron frequency {omega}{sub ce} have been observed experimentally, suggesting the possibility that instabilities can be excited in the beam tunnels and are responsible for the beam degradation. 2D electrostatic and electromagnetic time-dependent PIC codes have been developed to simulate the beam transport in the beam tunnel. The results of extensive parametric runs, using these codes (which were ported on the Cray T3D massively parallel computer), together with the role of the beam instabilities around {omega}{sub ce} on the beam degradation will be reported. (author) 2 figs., 9 refs.

  2. A COMPENSATOR APPLICATION USING SYNCHRONOUS MOTOR WITH A PI CONTROLLER BASED ON PIC

    Directory of Open Access Journals (Sweden)

    Ramazan BAYINDIR

    2009-01-01

    Full Text Available In this paper, PI control of a synchronous motor has been realized by using a PIC 18F452 microcontroller and it has been worked as ohmic, inductive and capacitive with different excitation currents. Instead of solving integral operation of PI control which has difficulties with conversion to the digital system, summation of all error values of a defined time period are multiplied with the sampling period. Reference values of the PI algorithm are determined with Ziegler-Nicholas method. These parameters are calculated into the microcontroller and changed according to the algorithm. In addition, this work designed to provide visualization for the users. Current, voltage and power factor data of the synchronous motor can be observed easily on the LCD instantly.

  3. PIC Simulations of the Effect of Velocity Space Instabilities on Electron Viscosity and Thermal Conduction

    Science.gov (United States)

    Riquelme, Mario A.; Quataert, Eliot; Verscharen, Daniel

    2016-06-01

    In low-collisionality plasmas, velocity-space instabilities are a key mechanism providing an effective collisionality for the plasma. We use particle-in-cell (PIC) simulations to study the interplay between electron- and ion-scale velocity-space instabilities and their effect on electron pressure anisotropy, viscous heating, and thermal conduction. The adiabatic invariance of the magnetic moment in low-collisionality plasmas leads to pressure anisotropy, {{Δ }}{p}j\\equiv {p}\\perp ,j-{p}\\parallel ,j\\gt 0, if the magnetic field {\\boldsymbol{B}} is amplified ({p}\\perp ,j and {p}\\parallel ,j denote the pressure of species j (electron, ion) perpendicular and parallel to {\\boldsymbol{B}}). If the resulting anisotropy is large enough, it can in turn trigger small-scale plasma instabilities. Our PIC simulations explore the nonlinear regime of the mirror, IC, and electron whistler instabilities, through continuous amplification of the magnetic field | {\\boldsymbol{B}}| by an imposed shear in the plasma. In the regime 1≲ {β }j≲ 20 ({β }j\\equiv 8π {p}j/| {\\boldsymbol{B}}{| }2), the saturated electron pressure anisotropy, {{Δ }}{p}{{e}}/{p}\\parallel ,{{e}}, is determined mainly by the (electron-lengthscale) whistler marginal stability condition, with a modest factor of ˜1.5-2 decrease due to the trapping of electrons into ion-lengthscale mirrors. We explicitly calculate the mean free path of the electrons and ions along the mean magnetic field and provide a simple physical prescription for the mean free path and thermal conductivity in low-collisionality β j ≳ 1 plasmas. Our results imply that velocity-space instabilities likely decrease the thermal conductivity of plasma in the outer parts of massive, hot, galaxy clusters. We also discuss the implications of our results for electron heating and thermal conduction in low-collisionality accretion flows onto black holes, including Sgr A* in the Galactic Center.

  4. Sistema Inteligente de Supervisión de Alarmas Basado en Microcontroladores PIC, SISAP

    Directory of Open Access Journals (Sweden)

    Ioslán Sánchez Martínez

    2010-09-01

    Full Text Available Normal 0 21 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} En este artículo se describe hasta la etapa presente de desarrollo del prototipo SISAP (Sistema Inteligente de Supervisión de Alarmas basado en Microcontroladores PICs desarrollado a partir de una propuesta de la Dirección Territorial de ETECSA de Sancti Spíritus con el fin de incrementar las prestaciones de los sistemas instalados para la supervisión de alarmas tecnológicas en centros no atendidos del territorio.  El dispositivo SISAP se encuentra en la versión de desarrollo 0.5 en estado “no concluido”. Hasta este punto es capaz de manejar hasta 40 eventos, que pueden ser on/off o nivele de voltaje y transmitirlos a través de una interfaz telefónica utilizando un protocolo de tonos DTMF. Palabras Clave: Alarmas, Microcontrolador PIC, Voltajes, Eventos on/off, Tonos DTMF.

  5. Activation of AMP-Activated Protein Kinase α and Extracelluar Signal-Regulated Kinase Mediates CB-PIC-Induced Apoptosis in Hypoxic SW620 Colorectal Cancer Cells.

    Science.gov (United States)

    Cho, Sung-Yun; Lee, Hyo-Jeong; Lee, Hyo-Jung; Jung, Deok-Beom; Kim, Hyunseok; Sohn, Eun Jung; Kim, Bonglee; Jung, Ji Hoon; Kwon, Byoung-Mog; Kim, Sung-Hoon

    2013-01-01

    Here, antitumor mechanism of cinnamaldehyde derivative CB-PIC was elucidated in human SW620 colon cancer cells. CB-PIC significantly exerted cytotoxicity, increased sub-G1 accumulation, and cleaved PARP with apoptotic features, while it enhanced the phosphorylation of AMPK alpha and ACC as well as activated the ERK in hypoxic SW620 cells. Furthermore, CB-PIC suppressed the expression of HIF1 alpha, Akt, and mTOR and activated the AMPK phosphorylation in hypoxic SW620 cells. Conversely, silencing of AMPK α blocked PARP cleavage and ERK activation induced by CB-PIC, while ERK inhibitor PD 98059 attenuated the phosphorylation of AMPK α in hypoxic SW620 cells, implying cross-talk between ERK and AMPK α . Furthermore, cotreatment of CB-PIC and metformin enhanced the inhibition of HIF1 α and Akt/mTOR and the activation of AMPK α and pACC in hypoxic SW620 cells. In addition, CB-PIC suppressed the growth of SW620 cells inoculated in BALB/c athymic nude mice, and immunohistochemistry revealed that CB-PIC treatment attenuated the expression of Ki-67, CD34, and CAIX and increased the expression of pAMPK α in CB-PIC-treated group. Interestingly, CP-PIC showed better antitumor activity in SW620 colon cancer cells under hypoxia than under normoxia, since it may be applied to chemoresistance. Overall, our findings suggest that activation of AMPK α and ERK mediates CB-PIC-induced apoptosis in hypoxic SW620 colon cancer cells.

  6. The Post-Intensive Care Syndrome (PICS) : Impact of ICU-stay on functioning and implications for rehabilitation care

    NARCIS (Netherlands)

    Dettling-Ihnenfeldt, D.S.

    2017-01-01

    Advancements in critical care medicine result in a growing population of survivors of critical illness. Many intensive care unit (ICU) patients have physical, mental and cognitive sequelae after discharge from the ICU, known as post-intensive care syndrome (PICS). These problems are associated with

  7. 2D PIC modeling of the EUV induced hydrogen plasma and comparison to the observed carbon etching rate

    NARCIS (Netherlands)

    Astakhov, Dmitry; Goedheer, W.J.; Lopaev, D.; Ivanov, V.; Krivtsun, V.M.; Yakushev, O.; Koshelev, K.; Bijkerk, Frederik

    2013-01-01

    The interaction between an EUV driven hydrogen plasma and a carbon covered surface was investigated using 2D PIC modeling and results were compared with experimental observations. The plasma is formed due to ionization of a low pressure hydrogen gas by the EUV photons and the photoelectrons from the

  8. Room-temperature fluorescence lifetime of pseudoisocyanine (PIC) J excitons with various aggregate morphologies in relation to microcavity polariton formation.

    Science.gov (United States)

    Obara, Yuki; Saitoh, Keita; Oda, Masaru; Tani, Toshiro

    2012-01-01

    The results of room-temperature fluorescence lifetime measurements are reported for the excitation of J aggregates (Js) of pseudoisocyanine chloride (PIC-Cl) prepared in potassium polyvinyl sulfate (PVS) polymer thin films, their aqueous solutions, and NaCl aqueous solutions. Variations of the microscopic morphologies of the aggregates were investigated. The results show that fluorescence decay features correlated to the morphology change. The observed fluorescence lifetime and quantum efficiency of PIC J aggregates (PIC-Js) in a NaCl aqueous solution were 310 ps and 28%, respectively. The lifetime of the fibril-shaped macroaggregates prepared in PVS thin films was below the instrumental time resolution of 5 ps, and the efficiency decreased to below 3%. The results indicate that PIC-Js prepared with PVS polymers have an increased nonradiative contribution to the excitation deactivation process. In particular, macro-Js with isolated fibril-shaped structures revealed nonradiative pathway(s) that are closely associated to the specific packaging morphology of the constituent meso-Js. The possibility of a destructive effect on the formation of cavity-polaritons is also discussed.

  9. Two new species and new records of the genus Spinolyprops Pic, 1917 from the Oriental Region (Coleoptera, Tenebrionidae, Lupropini) (*).

    Science.gov (United States)

    Schawaller, Wolfgang

    2012-01-01

    Two new species of the genus Spinolyprops Pic, 1917 (Tenebrionidae, subfamily Lagriinae Latreille, 1825) are described from Thailand and China (Spinolyprops cribricollissp. n., Spinolyprops thailandicussp. n.). The species characters within the genus are discussed, photographs of all seven Oriental species are added, a species key for the Oriental species is compiled, and a map with the distributional patterns is provided.

  10. Resolution of choroidal neovascularization secondary to punctate inner choroidopathy (PIC) with intravitreal anti-VEGF agents: a case series.

    Science.gov (United States)

    Mangat, Simran S; Ramasamy, B; Prasad, Som; Walters, Gavin; Mohammed, Moin; Mckibbin, Martin

    2011-01-01

    Case series of four patients with CNVM secondary to PIC treated solely with anti VEGF in three cases and in combination with PDT in the other. This series reveals long term follow up (3 months to 28 months) which is currently not described in the literature.

  11. 1.12 Tb/s superchannel coherent PM-QPSK InP transmitter photonic integrated circuit (PIC).

    Science.gov (United States)

    Evans, P; Fisher, M; Malendevich, R; James, A; Goldfarb, G; Vallaitis, T; Kato, M; Samra, P; Corzine, S; Strzelecka, E; Studenkov, P; Salvatore, R; Sedgwick, F; Kuntz, M; Lal, V; Lambert, D; Dentai, A; Pavinski, D; Zhang, J; Cornelius, J; Tsai, T; Behnia, B; Bostak, J; Dominic, V; Nilsson, A; Taylor, B; Rahn, J; Sanders, S; Sun, H; Wu, K-T; Pleumeekers, J; Muthiah, R; Missey, M; Schneider, R; Stewart, J; Reffle, M; Butrie, T; Nagarajan, R; Ziari, M; Kish, F; Welch, D

    2011-12-12

    In this work, a 10-wavelength, polarization-multiplexed, monolithically integrated InP coherent QPSK transmitter PIC is demonstrated to operate at 112 Gb/sec per wavelength and total chip superchannel bandwidth of 1.12 Tb/s. This demonstration suggests that increasing data capacity to multi-Tb/s per chip is possible and likely in the future.

  12. Complex coacervate core micelles.

    Science.gov (United States)

    Voets, Ilja K; de Keizer, Arie; Cohen Stuart, Martien A

    2009-01-01

    In this review we present an overview of the literature on the co-assembly of neutral-ionic block, graft, and random copolymers with oppositely charged species in aqueous solution. Oppositely charged species include synthetic (co)polymers of various architectures, biopolymers - such as proteins, enzymes and DNA - multivalent ions, metallic nanoparticles, low molecular weight surfactants, polyelectrolyte block copolymer micelles, metallo-supramolecular polymers, equilibrium polymers, etcetera. The resultant structures are termed complex coacervate core/polyion complex/block ionomer complex/interpolyelectrolyte complex micelles (or vesicles); i.e., in short C3Ms (or C3Vs) and PIC, BIC or IPEC micelles (and vesicles). Formation, structure, dynamics, properties, and function will be discussed. We focus on experimental work; theory and modelling will not be discussed. Recent developments in applications and micelles with heterogeneous coronas are emphasized.

  13. Synthesis, characterization and antibacterial activity of new complexes of some lanthanide ions with 15-crown-5 and 18-crown-6

    Directory of Open Access Journals (Sweden)

    Hussein Al-Amery

    2016-05-01

    Full Text Available Complexes of some lanthanide picrates (Ln3+ = Pr3+, Nd3+ and Dy3+ with 15-crown-5 and 18-crown-6 were synthesized and characterized by elemental analysis, ICP-AES, FTIR, 1H-NMR, 13C-NMR and UV-Visible spectrophotometric methods, thermal analysis (TGA & DTG, magnetic susceptibility , molar conductance and melting points. Also an in-vitro study on pathogenic gram positive (Staphylococcus aureus and pathogenic gram negative bacteria (Escherichia coli, Salmonella and pseudomonas aeruginosa was performed and the results were compared to those of a broad spectrum antibiotic (Chloramphinicol. The complexes of 15-crown-5 have the general formula [Ln(15C52(Pic]Pic2.nH2O where (Ln3+ = Nd3+ and Dy3+, (Pic = Picrate anion and (n = 2 or 4 except for Pr3+ complex which has the formula [Pr(15C5]Pic3.H2O , the 18-crown-6 complexes have the general formula [Ln(18C6]Pic3 where (Ln3+ = Pr3+ and Nd3+ except for Dy3+ complex which has the formula [Dy(18C6(Pic]Pic2.3H2O. In 15-crown-5 complexes both Nd3+ and Dy3+ were coordinated with two 15-crown-5 ligands and one picrate anion through its phenolic oxygen and the oxygen of it’s ortho nitro group, except for Pr3+ which was coordinated with only one 15-crown-5 ligand leaving three picrate anions as counter ions. In 18-crown-6 complexes both Pr3+ and Nd3+ were coordinated with one 18-crown-6 ligand leaving all the three picrate anions as counter ions outside the coordination sphere, except for the Dy3+ complex which was coordinated with one 18-crown-6 ligand and one picrate anion.

  14. Peptide inhibitor of complement C1 (PIC1, a novel suppressor of classical pathway activation: mechanistic studies and clinical potential

    Directory of Open Access Journals (Sweden)

    Julia A Sharp

    2014-08-01

    Full Text Available The classical pathway of complement plays multiple physiological roles including modulating immunological effectors initiated by adaptive immune responses as well as an essential homeostatic role in the clearance of damaged self-antigens. However, dysregulated classical pathway activation is associated with antibody-initiated, inflammatory diseases processes like cold agglutinin disease (CAD, acute intravascular hemolytic transfusion reaction (AIHTR and acute/hyperacute transplantation rejection. To date, only one putative classical pathway inhibitor, C1 esterase inhibitor (C1-INH, is currently commercially available and its only approved indication is for replacement treatment in hereditary angioedema (HAE, which is predominantly a kinin pathway disease. Given the variety of disease conditions in which the classical pathway is implicated, development of therapeutics that specifically inhibit complement initiation represents a major unmet medical need. Our laboratory has identified a peptide that specifically inhibits the classical and lectin pathways of complement. In vitro studies have demonstrated that these Peptide Inhibitors of Complement C1 (PIC1 bind to the collagen-like region of the initiator molecule of the classical pathway, C1q. PIC1 binding to C1q blocks activation of the associated serine proteases (C1s-C1r-C1r-C1s and subsequent downstream complement activation. Rational design optimization of PIC1 has resulted in the generation of a highly potent derivative of fifteen amino acids. PIC1 inhibits classical pathway mediated complement activation in ABO incompatibility in vitro as well as inhibiting classical pathway activation in vivo in rats. This review will focus on the pre-clinical development of PIC1 and discuss its potential as a therapeutic in antibody-mediated classical pathway disease, specifically AIHTR.

  15. Restoration of Akt activity by the bisperoxovanadium compound bpV(pic) attenuates hippocampal apoptosis in experimental neonatal pneumococcal meningitis.

    Science.gov (United States)

    Sury, Matthias D; Vorlet-Fawer, Lorianne; Agarinis, Claudia; Yousefi, Shida; Grandgirard, Denis; Leib, Stephen L; Christen, Stephan

    2011-01-01

    Pneumococcal meningitis causes apoptosis of developing neurons in the dentate gyrus of the hippocampus. The death of these cells is accompanied with long-term learning and memory deficits in meningitis survivors. Here, we studied the role of the PI3K/Akt (protein kinase B) survival pathway in hippocampal apoptosis in a well-characterized infant rat model of pneumococcal meningitis. Meningitis was accompanied by a significant decrease of the PI3K product phosphatidylinositol 3,4,5-trisphosphate (PIP(3)) and of phosphorylated (i.e., activated) Akt in the hippocampus. At the cellular level, phosphorylated Akt was decreased in both the granular layer and the subgranular zone of the dentate gyrus, the region where the developing neurons undergo apoptosis. Protein levels and activity of PTEN, the major antagonist of PI3K, were unaltered by infection, suggesting that the observed decrease in PIP(3) and Akt phosphorylation is a result of decreased PI3K signaling. Treatment with the PTEN inhibitor bpV(pic) restored Akt activity and significantly attenuated hippocampal apoptosis. Co-treatment with the specific PI3K inhibitor LY294002 reversed the restoration of Akt activity and attenuation of hippocampal apoptosis, while it had no significant effect on these parameters on its own. These results indicate that the inhibitory effect of bpV(pic) on apoptosis was mediated by PI3K-dependent activation of Akt, strongly suggesting that bpV(pic) acted on PTEN. Treatment with bpV(pic) also partially inhibited the concentration of bacteria and cytokines in the CSF, but this effect was not reversed by LY294002, indicating that the effect of bpV(pic) on apoptosis was independent of its effect on CSF bacterial burden and cytokine levels. These results indicate that the PI3K/Akt pathway plays an important role in the death and survival of developing hippocampal neurons during the acute phase of pneumococcal meningitis.

  16. On an accidental degeneracy in the {sup 31}P{l_brace}{sup 1}H{r_brace} NMR chemical shifts in ruthenium diphosphine complexes; Sobre uma degenerescencia acidental nos deslocamentos quimicos de RMN {sup 31}P{l_brace}{sup 1}H{r_brace} em complexos difosfinicos de rutenio

    Energy Technology Data Exchange (ETDEWEB)

    Valle, Eliana Maira Agostini; Nascimento, Fabio Batista do; Ferreira, Antonio Gilberto; Batista, Alzir A. [Universidade Federal de Sao Carlos (UFSCar), SP (Brazil). Dept. de Quimica]. E-mail: alzir@dq.ufscar.br; Monteiro, Marcos Claudio Rodrigues; Machado, Sergio de Paula [Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ (Brazil). Inst. de Quimica. Dept. de Quimica Inorganica; Ellena, Javier; Castellano, Eduardo E.; Azevedo, Eduardo Ribeiro de [Universidade de Sao Paulo (USP), Sao Carlos, SP (Brazil). Inst. de Fisica

    2008-07-01

    The [RuCl(bipy)(dppb)(4-pic)]PF{sub 6} complex was prepared and fully characterized. The X-ray crystal structure of this complex was determined in order to make an unambiguous distinction between the two possible positions of the 4-methylpyridine ligand (4-pic) in the compound: trans to phosphorus atom or trans to nitrogen atom. The [RuCl(bipy)(dppb)(4-pic)]PF{sub 6} complex exhibits an unusual temperature-dependent accidental degeneracy of the {sup 31}P chemical shifts in its solution NMR spectrum. (author)

  17. 基于PIC18F455O的环境监测数据采集系统设计%Design of A USB Data Acquisition System for Environment Monitoring Based on PIC18F4550 MCU

    Institute of Scientific and Technical Information of China (English)

    胡刚; 刘建鑫; 郭炜

    2012-01-01

    This article introduces a USB data acquisition system based on PIC18F4550 MCU and USB-HID Class, and describes an application of it. Related Circuits, MCU firmware and PC program are also introduced in detail. This system is characterized with practicability, inexpensiveness and rapidity of developing period.%介绍了基于PIC18F4550单片机和USB-HID类的数据采集系统,并列举了该系统在环保分析仪器中的应用实例.详细介绍了相关的电路设计、单片机固件程序和上位机程序的开发流程.该方案具有实用性强,成本低廉,开发周期短等特点.

  18. Correction of Double Byte Multiplication Subroutine in PIC16 MCU%PIC16单片机中双字节乘法子程序的更正

    Institute of Scientific and Technical Information of China (English)

    江和

    2007-01-01

    美国Microchip公司的PIC16系列单片机以其功能齐全、品种多、可靠性高著称,得到国内越来越多的相关技术人员的青睐。但是,PIC16系列单片机中无乘除指令,因此必须用加减和移位的办法实现乘法与除法运算。国内许多教材引用了Microchip公司的相关子程序或自编了通用子程序,给从事PIC系列单片机开发的人员带来了便利。

  19. 基于PIC16 F876的温湿度无线控制系统设计%The design of the temperature and humidity wireless control system based on PIC16 F876

    Institute of Scientific and Technical Information of China (English)

    吴宁; 尚坡利

    2015-01-01

    提出一种基于PIC16 F876单片机的温湿度无线智能控制系统。由于相应环境变量在控制中具有非线性、大时滞等特点,因此在控制算法中引入模糊PID算法。该控制系统设计先进,通用性强,试验证明该控制系统有一定的实用价值。%This paper put forward a temperature and humidity wireless intelligent control system based on PIC16F876 single chip. Because the environment variable has some control characteristics like the nonlinear and large time-delay, that introduced the fuzzy PID control algorithm. The control system design is advanced, strong commonality. Experiment proved that this control system has certain practical value.

  20. Simulation design of SPI communication based on PIC18F452 MCU%基于PIC18F452单片机SPI通信的仿真设计

    Institute of Scientific and Technical Information of China (English)

    胡燕清

    2016-01-01

    SPI是一种高速、全双工、同步的串行通信总线,本文对PIC18F452单片机SPI的结构、工作原理与工作模式进行了详细分析,并对单片机与单片机之间的双机SPI通信,和单片机之间的多机SPI通信进行了仿真设计。%SPI is ahigh-speed,full duplex,synchronous serial communication bus.In this paper,the structure,working principle and working mode of PIC18F452 MCU’s SPI were analyzed in detail,as well as the simulation designs of the double machine SPI communication between two MCUs,and the multi machine SPI communication between MCUs were finished successfully.

  1. Contactless Smart Car Design Based on PIC18F4520 Microcontroller%基于PIC18F4520单片机的遥控智能车设计

    Institute of Scientific and Technical Information of China (English)

    栾禄祥

    2015-01-01

    In this paper, using NRF24L01 wireless transceiver chip and a dedicated motor driver chip L298N based on PIC18F4520microcontroller, through the PWM pulse width control, it designed a four-wheel drive wireless remote control smart car, using the differential principle to achieve cornering function.%本文以PIC18F4520单片机为控制核心,采用NRF24L01无线收发芯片及专用的电机驱动芯片L298N,通过PWM脉宽调速,设计了一个采用四轮驱动,利用差速原理实现转弯功能的无线遥控智能小车。

  2. Design of IC water meter based on SCM PIC16F84%基于PIC16F84单片机的IC卡智能水表设计

    Institute of Scientific and Technical Information of China (English)

    李庆瑞; 袁魏华; 葛建峰

    2006-01-01

    本文介绍了一种基于低功耗芯片PIC16F84的IC卡智能水表的设计,文中给出了系统的硬件设计和软件设计.该IC卡水表具有低成本、低功耗、可靠性高等优点,可广泛应用于各城市供水系统.

  3. Application of PIC16F84 in Multifunctional Indicating System for Front Wheel Direction%PIC16F84在汽车多功能前轮偏转指示系统上的应用

    Institute of Scientific and Technical Information of China (English)

    林刚; 林小靖

    2008-01-01

    利用PIC16F84型单片机设计出汽车多功能前轮偏转指示系统,可及时提醒驾驶员调整转向盘,提高了驾驶的安全性.同时,设计中还增加了密码防盗功能.本设计电路简单,有很高的商业价值.

  4. AX.25协议在PIC16F877单片机上的实现%Realization of AX. 25 Protocol At PIC16F877 MCU

    Institute of Scientific and Technical Information of China (English)

    崔玉玲; 班建民

    2006-01-01

    本文介绍了利用AX.25协议构成分组无线网的方案,给出了基于AX.25协议的终端结点控制器的硬件和软件实现方法,讨论了AX.25协议在PIC16F877单片机上的设计与实现.

  5. Comparison of the PIC model and the Lie algebraic metnod in the simulation of intense continuous beam transport

    Institute of Scientific and Technical Information of China (English)

    ZHAO xiao-Song; L(U) Jian-Qin

    2009-01-01

    Both the PIC(Particle-In-Cell) model and the Lie algebraic method can be used to simulate the transport of intense continuous beams.The PIC model is to calculate the space charge field,which is blended into the external field,and then simulate the trajectories of particles in the total field;the Lie algebraic method is to simulate the intense continuous beam transport with transport matrixes.Two simulation codes based on the two methods are developed respectively,and the simulated results of transport in a set of electrostatic lenses are compared.It is found that the results from the two codes are in agreement with each other.and both approaches have their own merits.

  6. 2,3-Dihydrohomofarnesal: female sex attractant pheromone component of Callosobruchus rhodesianus (Pic).

    Science.gov (United States)

    Shimomura, Kenji; Koshino, Hiroyuki; Yajima, Arata; Matsumoto, Noriko; Kagohara, Yuuma; Kamada, Koichi; Yajima, Shunsuke; Ohsawa, Kanju

    2010-08-01

    Callosobruchus rhodesianus (Pic) (Coleoptera: Chrysomelidae: Bruchinae) is a pest of stored legumes through the Afro-tropical region. In laboratory bioassays, males of C. rhodesianus were attracted to volatiles collected from virgin females. Collections were purified by various chromatographic techniques, and the biologically active component isolated using gas chromatographic-electroantennographic detection analysis. Gas chromatography-mass spectrometry and NMR analyses suggested that the active compound was 2,3-dihydrohomofarnesal, i.e., 7-ethyl-3,11-dimethyl-6,10-dodecadienal. The structure was confirmed by non-stereoselective and enantioselective total synthesis. Using chiral gas chromatography, the absolute configuration of the natural compound was confirmed as (3S,6E)-7-ethyl-3,11-dimethyl-6,10-dodecadienal. Y-tube olfactomter assays showed that only the (S)-enantiomer attracted males of C. rhodesianus. The (R)-enantiomer and racemate did not attract males, suggesting that the (R)-enantiomer inhibits the activity of the natural compound. In combination with previous reports about sex attractant pheromones of congeners, we suggest that a saltational shift of the pheromone structure arose within the genus Callosobruchus.

  7. Neutron imaging detector based on the {mu}PIC micro-pixel chamber

    Energy Technology Data Exchange (ETDEWEB)

    Parker, J.D., E-mail: jparker@cr.scphys.kyoto-u.ac.jp [Department of Physics, Graduate School of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502 (Japan); Hattori, K.; Fujioka, H. [Department of Physics, Graduate School of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502 (Japan); Harada, M. [Materials and Life Science Facility Division, Japan Atomic Energy Agency (JAEA), Tokai, Ibaraki 319-1195 (Japan); Iwaki, S.; Kabuki, S.; Kishimoto, Y.; Kubo, H.; Kurosawa, S.; Miuchi, K.; Nagae, T.; Nishimura, H. [Department of Physics, Graduate School of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502 (Japan); Oku, T. [Materials and Life Science Facility Division, Japan Atomic Energy Agency (JAEA), Tokai, Ibaraki 319-1195 (Japan); Sawano, T. [Department of Physics, Graduate School of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502 (Japan); Shinohara, T.; Suzuki, J. [Materials and Life Science Facility Division, Japan Atomic Energy Agency (JAEA), Tokai, Ibaraki 319-1195 (Japan); Takada, A.; Tanimori, T.; Ueno, K. [Department of Physics, Graduate School of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502 (Japan)

    2013-01-01

    We have developed a prototype time-resolved neutron imaging detector employing the micro-pixel chamber ({mu}PIC), a micro-pattern gaseous detector, coupled with a field programmable gate array-based data acquisition system for applications in neutron radiography at high-intensity neutron sources. The prototype system, with an active area of 10 Multiplication-Sign 10 cm{sup 2} and operated at a gas pressure of 2 atm, measures both the energy deposition (via time-over-threshold) and three-dimensional track of each neutron-induced event, allowing the reconstruction of the neutron interaction point with improved accuracy. Using a simple position reconstruction algorithm, a spatial resolution of 349{+-}36{mu}m was achieved, with further improvement expected. The detailed tracking allows strong rejection of background gamma-rays, resulting in an effective gamma sensitivity of 10{sup -12} or less, coupled with stable, robust neutron identification. The detector also features a time resolution of 0.6{mu}s.

  8. PIC/MCC simulation for magnetized capacitively coupled plasmas driven by combined dc/rf sources

    Science.gov (United States)

    Yang, Shali; Zhang, Ya; Jiang, Wei; Wang, Hongyu; Wang, Shuai

    2016-09-01

    Hybrid dc/rf capacitively coupled plasma (CCP) sources have been popular in substrate etching due to their simplicity in the device structure and better plasma property. In this work, the characteristics of magnetized capacitively coupled plasmas driven by combined dc/rf sources are described by a one-dimensional Particle-in-cell/Monte Carlo collision (PIC/MCC) model. The simulation is using a rf source of 13.56MHz in argon and at a low pressure of 50mTorr. The effects of dc voltage and magnetic field on the plasmas are examined for 200-400V and 0-200Gs. It is found that, to some extent, dc voltage will increase the plasma density, but plasma density drops with increasing dc voltage. The magnetic field will enhance the plasma density significantly, due to the magnetic field will increase the electron life time and decrease the loss to the electrodes. In the bulk plasma, electron temperature is increased with the magnetic field but decreased with the dc voltage. The electron temperature in sheath is higher than in bulk plasma, due to stochastic heating in sheath is greater than Ohmic heating in bulk plasma under low gas pressure. National Natural Science Foundation of China (11405067, 11105057, 11305032, 11275039).

  9. PIC simulations of the trapped electron filamentation instability in finite-width electron plasma waves

    Science.gov (United States)

    Winjum, B. J.; Banks, J. W.; Berger, R. L.; Cohen, B. I.; Chapman, T.; Hittinger, J. A. F.; Rozmus, W.; Strozzi, D. J.; Brunner, S.

    2012-10-01

    We present results on the kinetic filamentation of finite-width nonlinear electron plasma waves (EPW). Using 2D simulations with the PIC code BEPS, we excite a traveling EPW with a Gaussian transverse profile and a wavenumber k0λDe= 1/3. The transverse wavenumber spectrum broadens during transverse EPW localization for small width (but sufficiently large amplitude) waves, while the spectrum narrows to a dominant k as the initial EPW width increases to the plane-wave limit. For large EPW widths, filaments can grow and destroy the wave coherence before transverse localization destroys the wave; the filaments in turn evolve individually as self-focusing EPWs. Additionally, a transverse electric field develops that affects trapped electrons, and a beam-like distribution of untrapped electrons develops between filaments and on the sides of a localizing EPW. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344 and funded by the Laboratory Research and Development Program at LLNL under project tracking code 12-ERD-061. Supported also under Grants DE-FG52-09NA29552 and NSF-Phy-0904039. Simulations were performed on UCLA's Hoffman2 and NERSC's Hopper.

  10. A PIC Simulation Study of Electron Viscosity and Thermal Conduction in Collisionless Plasmas

    Science.gov (United States)

    Riquelme, Mario; Quataert, Eliot; Verscharen, Daniel

    2016-10-01

    We use particle-in-cell (PIC) simulations to study the interplay between electron- and ion-scale velocity-space instabilities and their effect on electron pressure anisotropy, viscous heating, and thermal conduction. The adiabatic invariance of the magnetic moment in low-collisionality plasmas gives rise to pressure anisotropy, with p⊥ , j -p∥ , j > 0 ( | grows (decreases), where p⊥ , j and p∥ , j denote the pressure of species j [electron or ion] perpendicular and parallel to B-> . If the resulting anisotropy is large enough, it can trigger small-scale plasma instabilities. By imposing a shear in the plasma we either amplify or decrease the magnetic field | B-> | . When | B-> | is amplified, we explored the nonlinear regime of the mirror, ion-cyclotron, and electron whistler instabilities. When | B-> | is decreased, we studied the nonlinear regime of the ion- and electron-firehose instabilities. We discuss the implications of our results for electron heating and thermal conduction in low-collisionality accretion flows onto black holes, like Sgr A*. We also discuss the possible implications for the thermal conductivity of plasma in the outer parts of massive, hot, galaxy clusters.

  11. PIC Simulations of the Temperature Anisotropy-Driven Weibel Instability: Analyzing the perpendicular mode

    CERN Document Server

    Stockem, A; Schlickeiser, R

    2010-01-01

    An instability driven by the thermal anisotropy of a single electron species is investigated in a 2D particle-in-cell (PIC) simulation. This instability is the one considered by Weibel and it differs from the beam driven filamentation instability. A comparison of the simulation results with analytic theory provides similar exponential growth rates of the magnetic field during the linear growth phase of the instability. We observe in accordance with previous works the growth of electric fields during the saturation phase of the instability. Some components of this electric field are not accounted for by the linearized theory. A single-fluid-based theory is used to determine the source of this nonlinear electric field. It is demonstrated that the magnetic stress tensor, which vanishes in a 1D geometry, is more important in this 2-dimensional model used here. The electric field grows to an amplitude, which yields a force on the electrons that is comparable to the magnetic one. The peak energy density of each mag...

  12. Probing particle acceleration in lower hybrid turbulence via synthetic diagnostics produced by PIC simulations

    Science.gov (United States)

    Cruz, F.; Fonseca, R. A.; Silva, L. O.; Rigby, A.; Gregori, G.; Bamford, R. A.; Bingham, R.; Koenig, M.

    2016-10-01

    Efficient particle acceleration in astrophysical shocks can only be achieved in the presence of initial high energy particles. A candidate mechanism to provide an initial seed of energetic particles is lower hybrid turbulence (LHT). This type of turbulence is commonly excited in regions where space and astrophysical plasmas interact with large obstacles. Due to the nature of LH waves, energy can be resonantly transferred from ions (travelling perpendicular to the magnetic field) to electrons (travelling parallel to it) and the consequent motion of the latter in turbulent shock electromagnetic fields is believed to be responsible for the observed x-ray fluxes from non-thermal electrons produced in astrophysical shocks. Here we present PIC simulations of plasma flows colliding with magnetized obstacles showing the formation of a bow shock and the consequent development of LHT. The plasma and obstacle parameters are chosen in order to reproduce the results obtained in a recent experiment conducted at the LULI laser facility at Ecole Polytechnique (France) to study accelerated electrons via LHT. The wave and particle spectra are studied and used to produce synthetic diagnostics that show good qualitative agreement with experimental results. Work supported by the European Research Council (Accelerates ERC-2010-AdG 267841).

  13. The MICHELLE 2D/3D ES PIC Code Advances and Applications

    CERN Document Server

    Petillo, John; De Ford, John F; Dionne, Norman J; Eppley, Kenneth; Held, Ben; Levush, Baruch; Nelson, Eric M; Panagos, Dimitrios; Zhai, Xiaoling

    2005-01-01

    MICHELLE is a new 2D/3D steady-state and time-domain particle-in-cell (PIC) code* that employs electrostatic and now magnetostatic finite-element field solvers. The code has been used to design and analyze a wide variety of devices that includes multistage depressed collectors, gridded guns, multibeam guns, annular-beam guns, sheet-beam guns, beam-transport sections, and ion thrusters. Latest additions to the MICHELLE/Voyager tool are as follows: 1) a prototype 3D self magnetic field solver using the curl-curl finite-element formulation for the magnetic vector potential, employing edge basis functions and accumulating current with MICHELLE's new unstructured grid particle tracker, 2) the electrostatic field solver now accommodates dielectric media, 3) periodic boundary conditions are now functional on all grids, not just structured grids, 4) the addition of a global optimization module to the user interface where both electrical parameters (such as electrode voltages)can be optimized, and 5) adaptive mesh ref...

  14. Generation of Multiband Chorus in the Earth's Magnetosphere: 1-D PIC Simulation

    Science.gov (United States)

    Gao, Xinliang; Ke, Yangguang; Lu, Quanming; Chen, Lunjin; Wang, Shui

    2017-01-01

    Multiband chorus waves, where the frequency of upper band chorus is about twice that of lower band chorus, have recently been reported based on THEMIS observations. The generation of multiband chorus waves is attributed to the mechanism of lower band cascade, where upper band chorus is excited via the nonlinear coupling process between lower band chorus and the associated density mode with the frequency equal to that of lower band chorus. In this letter, with a one-dimensional (1-D) particle-in-cell (PIC) simulation model, we have successfully reproduced multiband chorus waves. During the simulation, the significant density fluctuation is driven by the fluctuating electric field along the wave vector of the pump wave (lower band chorus), which can be directly observed in this self-consistent plasma system. Then, the second harmonic of the pump whistler-mode wave (upper band chorus) is generated. After quantitatively analyzing resonant conditions among wave numbers, we can confirm that the generation is caused due to the coupling between the pump wave and the density fluctuation along its wave vector. The third harmonic can also be excited through lower band cascade if the pump whistler-mode wave has a sufficiently large amplitude. Our simulation results not only provide a theoretical support to the mechanism of lower band cascade to generate multiband chorus but also propose a new pattern of evolution for whistler-mode waves in the Earth's magnetosphere.

  15. 3-D Parallel, Object-Oriented, Hybrid, PIC Code for Ion Ring Studies

    Science.gov (United States)

    Omelchenko, Y. A.

    1997-08-01

    The 3-D hybrid, Particle-in-Cell (PIC) code, FLAME has been developed to study low-frequency, large orbit plasmas in realistic cylindrical configurations. FLAME assumes plasma quasineutrality and solves the Maxwell equations with displacement current neglected. The electron component is modeled as a massless fluid and all ion components are represented by discrete macro-particles. The poloidal discretization is done by a finite-difference staggered grid method. FFT is applied in the azimuthal direction. A substantial reduction of CPU time is achieved by enabling separate time advances of background and beam particle species in the time-averaged fields. The FLAME structure follows the guidelines of object-oriented programming. Its C++ class hierarchy comprises the Utility, Geometry, Particle, Grid and Distributed base class packages. The latter encapsulates implementation of concurrent grid and particle algorithms. The particle and grid data interprocessor communications are unified and designed to be independent of both the underlying message-passing library and the actual poloidal domain decomposition technique (FFT's are local). Load balancing concerns are addressed by using adaptive domain partitions to account for nonuniform spatial distributions of particle objects. The results of 2-D and 3-D FLAME simulations in support of the FIREX program at Cornell are presented.

  16. Hybrid-PIC Modeling of the Transport of Atomic Boron in a Hall Thruster

    Science.gov (United States)

    Smith, Brandon D.; Boyd, Iaian D.; Kamhawi, Hani

    2015-01-01

    Computational analysis of the transport of boron eroded from the walls of a Hall thruster is performed by implementing sputter yields of hexagonal boron nitride and velocity distribution functions of boron within the hybrid-PIC model HPHall. The model is applied to simulate NASA's HiVHAc Hall thruster at a discharge voltage of 500V and discharge powers of 1-3 kW. The number densities of ground- and 4P-state boron are computed. The density of ground-state boron is shown to be a factor of about 30 less than the plasma density. The density of the excited state is shown to be about three orders of magnitude less than that of the ground state, indicating that electron impact excitation does not significantly affect the density of ground-state boron in the discharge channel or near-field plume of a Hall thruster. Comparing the rates of excitation and ionization suggests that ionization has a greater influence on the density of ground-state boron, but is still negligible. The ground-state boron density is then integrated and compared to cavity ring-down spectroscopy (CRDS) measurements for each operating point. The simulation results show good agreement with the measurements for all operating points and provide evidence in support of CRDS as a tool for measuring Hall thruster erosion in situ.

  17. Australian marsh beetles (Coleoptera: Scirtidae). 6. Genera Calvarium Pic, Papuacyphon Zwick, and Ypsiloncyphon Klausnitzer.

    Science.gov (United States)

    Zwick, Peter

    2014-07-31

    The genus Calvarium Pic, 1918 is for the first time recorded from Australia. Six new Australian species are named and described. Calvarium australiense n. sp. and C. superbum n. sp. from the Northern Territory are typical representatives of the genus. A new subgenus, Calvariellum n. subgen., is proposed for four species from NE Queensland which share general body structure with other Calvarium species but have different, less derived male genitalia: Calvarium (Calvariellum) bellendenker n. sp., C. (Calvariellum) cochlearifer n. sp., C. (Calvariellum) hamifer n. sp., and C. (Calvariellum) lancifer n. sp. Papuacyphon darwini n. sp. is described from SW Australia. The genus was previously known only from Papua New Guinea. Species Group 3 of the genus Ypsiloncyphon Klausnitzer, 2009 is first recorded from Australia. It is endemic to the Australasian region. The Australian species Y. angustus n. sp., Y. brevis n. sp., Y. katherinae n. sp., Y. longus n. sp., Y. pusillus n. sp., Y. velatus n. sp., and Y. virgulifer n. sp. are described, the New Guinean species Y. micans (Klausnitzer, 1973) (= Cyphon paramicans Klausnitzer, 1973, n. syn.), Y. mutilatus n. sp., Y. ruficollis n. sp., and Y. rugosus n. sp. are described or redescribed from types, respectively. Three Australian species known only in the female sex are described under informal designations.

  18. Dissipation in PIC simulations of moderate to low \\b{eta} plasma turbulence

    CERN Document Server

    Makwana, Kirit; Guo, Fan; Li, Xiaocan

    2016-01-01

    We simulate decaying turbulence in electron-positron pair plasmas using a fully- kinetic particle-in-cell (PIC) code. We run two simulations with moderate-to-low plasma beta. The energy decay rate is found to be similar in both the cases. The perpendicular wave-number spectrum of magnetic energy shows a slope of k^-1.3 in both the cases. The particle energy distribution function shows the formation of a non-thermal feature in the case of lower plasma beta, with a slope close to E^-1. The role of thin turbulent current sheets in this process is investigated. The heating by E_{\\parallel}.J_{\\parallel} term dominates the E_{\\perp}.J_{\\perp} term. Regions of strong E_{\\parallel}.J_{\\parallel} are spatially well-correlated with regions of intense current sheets, which also appear correlated with regions of strong E_{\\parallel} in the low beta simulation, suggesting an important role of magnetic reconnection in the dissipation of low beta plasma turbulence.

  19. Hybrid-PIC Computer Simulation of the Plasma and Erosion Processes in Hall Thrusters

    Science.gov (United States)

    Hofer, Richard R.; Katz, Ira; Mikellides, Ioannis G.; Gamero-Castano, Manuel

    2010-01-01

    HPHall software simulates and tracks the time-dependent evolution of the plasma and erosion processes in the discharge chamber and near-field plume of Hall thrusters. HPHall is an axisymmetric solver that employs a hybrid fluid/particle-in-cell (Hybrid-PIC) numerical approach. HPHall, originally developed by MIT in 1998, was upgraded to HPHall-2 by the Polytechnic University of Madrid in 2006. The Jet Propulsion Laboratory has continued the development of HPHall-2 through upgrades to the physical models employed in the code, and the addition of entirely new ones. Primary among these are the inclusion of a three-region electron mobility model that more accurately depicts the cross-field electron transport, and the development of an erosion sub-model that allows for the tracking of the erosion of the discharge chamber wall. The code is being developed to provide NASA science missions with a predictive tool of Hall thruster performance and lifetime that can be used to validate Hall thrusters for missions.

  20. Hybrid-PIC Modeling of a High-Voltage, High-Specific-Impulse Hall Thruster

    Science.gov (United States)

    Smith, Brandon D.; Boyd, Iain D.; Kamhawi, Hani; Huang, Wensheng

    2013-01-01

    The primary life-limiting mechanism of Hall thrusters is the sputter erosion of the discharge channel walls by high-energy propellant ions. Because of the difficulty involved in characterizing this erosion experimentally, many past efforts have focused on numerical modeling to predict erosion rates and thruster lifespan, but those analyses were limited to Hall thrusters operating in the 200-400V discharge voltage range. Thrusters operating at higher discharge voltages (V(sub d) >= 500 V) present an erosion environment that may differ greatly from that of the lower-voltage thrusters modeled in the past. In this work, HPHall, a well-established hybrid-PIC code, is used to simulate NASA's High-Voltage Hall Accelerator (HiVHAc) at discharge voltages of 300, 400, and 500V as a first step towards modeling the discharge channel erosion. It is found that the model accurately predicts the thruster performance at all operating conditions to within 6%. The model predicts a normalized plasma potential profile that is consistent between all three operating points, with the acceleration zone appearing in the same approximate location. The expected trend of increasing electron temperature with increasing discharge voltage is observed. An analysis of the discharge current oscillations shows that the model predicts oscillations that are much greater in amplitude than those measured experimentally at all operating points, suggesting that the differences in oscillation amplitude are not strongly associated with discharge voltage.

  1. Peptide Inhibitor of Complement C1 (PIC1 Rapidly Inhibits Complement Activation after Intravascular Injection in Rats.

    Directory of Open Access Journals (Sweden)

    Julia A Sharp

    Full Text Available The complement system has been increasingly recognized to play a pivotal role in a variety of inflammatory and autoimmune diseases. Consequently, therapeutic modulators of the classical, lectin and alternative pathways of the complement system are currently in pre-clinical and clinical development. Our laboratory has identified a peptide that specifically inhibits the classical and lectin pathways of complement and is referred to as Peptide Inhibitor of Complement C1 (PIC1. In this study, we determined that the lead PIC1 variant demonstrates a salt-dependent binding to C1q, the initiator molecule of the classical pathway. Additionally, this peptide bound to the lectin pathway initiator molecule MBL as well as the ficolins H, M and L, suggesting a common mechanism of PIC1 inhibitory activity occurs via binding to the collagen-like tails of these collectin molecules. We further analyzed the effect of arginine and glutamic acid residue substitution on the complement inhibitory activity of our lead derivative in a hemolytic assay and found that the original sequence demonstrated superior inhibitory activity. To improve upon the solubility of the lead derivative, a pegylated, water soluble variant was developed, structurally characterized and demonstrated to inhibit complement activation in mouse plasma, as well as rat, non-human primate and human serum in vitro. After intravenous injection in rats, the pegylated derivative inhibited complement activation in the blood by 90% after 30 seconds, demonstrating extremely rapid function. Additionally, no adverse toxicological effects were observed in limited testing. Together these results show that PIC1 rapidly inhibits classical complement activation in vitro and in vivo and is functional for a variety of animal species, suggesting its utility in animal models of classical complement-mediated diseases.

  2. 再谈如何实现PIC16系列单片机的查表

    Institute of Scientific and Technical Information of China (English)

    廖珍爱

    2004-01-01

    拜读了本刊第六期《PIC单片机查表指令安全性分析初探》一文,读后感觉有余意未尽之处,特补充本文,希望能对读者正确理解PIC16系列单片机的查表有所帮助。

  3. AX.25协议在PIC16F877单片机上的实现

    Institute of Scientific and Technical Information of China (English)

    崔玉玲; 班建民

    2006-01-01

    本文介绍了利用AX.25协议构成分组无线网的方案,给出了基于AX.25协议的终端结点控制器的硬件和软件实现方法.讨论了AX.25协议在PIC16F877单片机上的设计与实现。

  4. Modeling of Wireless Energy Transfer Circuit and Implementation of Wi-tricity System Control using Infrared and PIC Microcontroller

    OpenAIRE

    N. R. Mohamad; A. Salleh; N.M.Z. Hashim; M. Z. A Abd Aziz; Zakaria, Z.

    2016-01-01

    A prototypes to prove and demonstrate the concept of Wireless Energy Transfer (WET) is proposed in this paper. The prototype is a simple structure consist of a transmitter as an electromagnetic resonator and a receiver to which the device to be powered is attached. It also implements with an ON/OFF control system using the Infrared (IR) module and Programmable Integrated Circuit (PIC) microcontroller. As a whole, experimental result proved that the distance between two coils is inversely d...

  5. Large Scale Earth’s Bow Shock with Northern IMF as Simulated by PIC Code in Parallel with MHD Model

    Indian Academy of Sciences (India)

    Suleiman Baraka

    2016-06-01

    In this paper, we propose a 3D kinetic model (particle-in-cell, PIC) for the description of the large scale Earth’s bow shock. The proposed version is stable and does not require huge or extensive computer resources. Because PIC simulations work with scaled plasma and field parameters, we also propose to validate our code by comparing its results with the available MHD simulations under same scaled solar wind (SW) and (IMF) conditions. We report new results from the two models. In both codes the Earth’s bow shock position is found to be $\\approx 14.8 R_{{\\rm E}}$ along the Sun–Earth line, and $\\approx 29 R_{{\\rm E}}$ on the dusk side. Those findings are consistent with past in situ observations. Both simulations reproduce the theoretical jump conditions at the shock. However, the PIC code density and temperature distributions are inflated and slightly shifted sunward when compared to the MHD results. Kinetic electron motions and reflected ions upstream may cause this sunward shift. Species distributions in the foreshock region are depicted within the transition of the shock (measured $\\approx$2$c/\\omega_{pi}$ for $ \\Theta_{Bn}=90^{\\circ}$ and $M_{{\\rm MS}} = 4.7 $) and in the downstream. The size of the foot jump in the magnetic field at the shock is measured to be ($1.7 c/ \\omega_{pi} $). In the foreshocked region, the thermal velocity is found equal to 213 km $s^{−1}$ at $15R_{{\\rm E}}$ and is equal to $63 km s^{-1}$ at $12 R_{{\\rm E}}$ (magnetosheath region). Despite the large cell size of the current version of the PIC code, it is powerful to retain macrostructure of planets magnetospheres in very short time, thus it can be used for pedagogical test purposes. It is also likely complementary with MHD to deepen our understanding of the large scale magnetosphere.

  6. A new species of Falsocaenia Pic, 1922 from Amazonian Rainforest (Coleoptera: Lycidae) with an updated key to the species.

    Science.gov (United States)

    Ferreira, Vinicius S

    2016-04-25

    While searching for Calochromini (Coleoptera: Lycidae) specimens in entomological collections and identifying other Lycidae, a new species of Falsocaenia Pic, 1922 was found in the collection of Instituto Nacional de Pesquisas da Amazônia (INPA). This genus is one of the smallest in the tribe Calopterini with 13 known species, two of which were recently described by Bocákova et al. (2012) in their revision of the genus, and can be found in Central and South America.

  7. Glenea coomani Pic, 1926 and its related species of South China with description of a new species.

    Science.gov (United States)

    Lin, Meiying; Yang, Xingke

    2011-01-01

    Glenea coomani Pic, 1926 distributed in Vietnam, Laos and China is redescribed, and its sibling species, Glenea neohumerosasp. n. is described from China (Guangxi, Hainan and Fujian) and North Vietnam. They are separated from each otherby differences in genitalia, and apical teeth and maculae of elytra. Another four related species and one subspecies are illustrated with short notes and new localities, and the lectotype and paralectotype of Glenea tonkinea Aurivillius, 1925 are designated. A key to the related species is presented.

  8. Morfologia do vírus do mosaico do picão Morphology of the bidens mosaic virus particle

    Directory of Open Access Journals (Sweden)

    Elliot W. Kitajima

    1961-01-01

    Full Text Available Preparações feitas com exsudato de plantas de fumo, girassol, picão, erva--de-Santa-Maria, cordão-de-frade, fedegoso. Chenopodium amaranticolor e Physalis floridana, sadias e infectadas pelo vínis do mosaico do picão, foram examinadas ao microscópio electrônico. Partículas com comprimento normal aproximado de 720 mm x 12-13 mm, foram encontradas nos exsudatos das oito espécies, quando afetadas, mas não nos das plantas sadias, testemunhas. Tais partículas são consideradas como sendo o vírus causador do mosaico do picão.Electron microscopical observations were made on exudates obtained from plants of Bidrus pilosa, Chenopodium amaranticolor Leonolis nepaetifolia, Helianthus annums. Nicotiana tabucum, Cassia occidentalis, Chenopodium ambrosioides, and Physalis floridona infected with a virus that induces mosaic on the first named species. The presenes of a flexible thread with a normal length 720 mm. x 12-13 mm was recorded in the exudates from the: diseased plants, but not in those from the healthy ones, and is considered to represent the causal virus.

  9. Conductor backed and shielded multi-layer coplanar waveguide designs on LTCC for RF carrier boards for packaging PICs

    Science.gov (United States)

    Marraccini, Philip J.; Jezzini, Moises A.; Peters, Frank H.

    2016-05-01

    Designing photonic integrated circuits (PICs) with packaging in mind is important since this impacts the performance of the final product. In coherent optical communication applications there are a large number of DC and RF lines that need routed to connect the PIC to the outer packaging. These RF lines should be impedance matched to the devices, isolated from each other, low loss and protected against electromagnetic interference (EMI) over the frequency range of interest to achieve the performance required for the application. Multilevel low temperature co-fired ceramic (LTCC) boards can be used as a carrier board connecting the PIC to the packaging due to its good RF performance, machinability, compatibility with hermetic sealing, and ability to integrate drivers into the board. Flexibility with layer numbers enables additional layers for shielding against electromagnetic interference or increased space for routing electrical connections. In this paper the design, simulations, and measured results for a set of 4 phase matched transmission lines in LTCC that would be used with an IQ MZM are presented. The measured 3dB bandwidth for a set of four phase matched transmission lines for an IQ MZM was measured to be 19.8 GHz.

  10. Large Scale Earth's Bow Shock with Northern IMF as simulated by PIC code in parallel with MHD model

    CERN Document Server

    Baraka, Suleiman M

    2016-01-01

    In this paper, we propose a 3D kinetic model (Particle-in-Cell PIC ) for the description of the large scale Earth's bow shock. The proposed version is stable and does not require huge or extensive computer resources. Because PIC simulations work with scaled plasma and field parameters, we also propose to validate our code by comparing its results with the available MHD simulations under same scaled Solar wind ( SW ) and ( IMF ) conditions. We report new results from the two models. In both codes the Earth's bow shock position is found to be ~14.8 RE along the Sun-Earth line, and ~ 29 RE on the dusk side. Those findings are consistent with past in situ observations. Both simulations reproduce the theoretical jump conditions at the shock. However, the PIC code density and temperature distributions are inflated and slightly shifted sunward when compared to the MHD results. Kinetic electron motions and reflected ions upstream may cause this sunward shift. Species distributions in the foreshock region are depicted...

  11. Comparisons of time explicit hybrid kinetic-fluid code Architect for Plasma Wakefield Acceleration with a full PIC code

    Science.gov (United States)

    Massimo, F.; Atzeni, S.; Marocchino, A.

    2016-12-01

    Architect, a time explicit hybrid code designed to perform quick simulations for electron driven plasma wakefield acceleration, is described. In order to obtain beam quality acceptable for applications, control of the beam-plasma-dynamics is necessary. Particle in Cell (PIC) codes represent the state-of-the-art technique to investigate the underlying physics and possible experimental scenarios; however PIC codes demand the necessity of heavy computational resources. Architect code substantially reduces the need for computational resources by using a hybrid approach: relativistic electron bunches are treated kinetically as in a PIC code and the background plasma as a fluid. Cylindrical symmetry is assumed for the solution of the electromagnetic fields and fluid equations. In this paper both the underlying algorithms as well as a comparison with a fully three dimensional particle in cell code are reported. The comparison highlights the good agreement between the two models up to the weakly non-linear regimes. In highly non-linear regimes the two models only disagree in a localized region, where the plasma electrons expelled by the bunch close up at the end of the first plasma oscillation.

  12. Highly durable photochromic radical complexes having no steric protections of radicals.

    Science.gov (United States)

    Kobayashi, Yoichi; Mishima, Yasuhiro; Mutoh, Katsuya; Abe, Jiro

    2017-04-21

    Steric protection groups are usually necessary for stable radicals. However, here, we developed novel photochromic radical complexes which generate sterically unprotected imidazolyl and phenoxyl radicals upon UV light irradiation based on the phenoxyl-imidazolyl radical complex (PIC) framework. These photochromic compounds show excellent durability against repeated irradiation of intense nanosecond laser pulses even in polar protic solvents, such as ethanol.

  13. The Pic19 NBS-LRR gene family members are closely linked to Scmv1, but not involved in maize resistance to sugarcane mosaic virus

    DEFF Research Database (Denmark)

    Jiang, Lu; Ingvardsen, Christina Rønn; Lübberstedt, Thomas;

    2008-01-01

    Sugarcane mosaic virus (SCMV) is the causal pathogen for a severe mosaic virus disease of maize worldwide. In our previous research, the maize resistance gene analog (RGA) Pic19 and its three cognate BAC contigs were mapped to the same region as the SCMV resistance gene Scmv1. Here we report...... the isolation and characterization of the Pic19R gene family members from the inbred line FAP1360A, which shows complete resistance to SCMV. Two primer pairs were designed based on the conserved regions among the known Pic19 paralogs and used for rapid amplification of cDNA ends of FAP1360A. Six full-length c......DNAs, corresponding to the Pic19R-1 to -6 paralogs, were obtained. Three of them (Pic19R-1 to -3) had uninterrupted coding sequences and were, therefore, regarded as candidates for the Scmv1 gene. A total of 18 positive BAC clones harboring the Pic19R-2 to -5 paralogs were obtained from the FAP1360A BAC library...

  14. Ligand Efficiency Outperforms pIC50 on Both 2D MLR and 3D CoMFA Models: A Case Study on AR Antagonists.

    Science.gov (United States)

    Li, Jiazhong; Bai, Fang; Liu, Huanxiang; Gramatica, Paola

    2015-12-01

    The concept of ligand efficiency is defined as biological activity in each molecular size and is widely accepted throughout the drug design community. Among different LE indices, surface efficiency index (SEI) was reported to be the best one in support vector machine modeling, much better than the generally and traditionally used end-point pIC50. In this study, 2D multiple linear regression and 3D comparative molecular field analysis methods are employed to investigate the structure-activity relationships of a series of androgen receptor antagonists, using pIC50 and SEI as dependent variables to verify the influence of using different kinds of end-points. The obtained results suggest that SEI outperforms pIC50 on both MLR and CoMFA models with higher stability and predictive ability. After analyzing the characteristics of the two dependent variables SEI and pIC50, we deduce that the superiority of SEI maybe lie in that SEI could reflect the relationship between molecular structures and corresponding bioactivities, in nature, better than pIC50. This study indicates that SEI could be a more rational parameter to be optimized in the drug discovery process than pIC50. © 2015 John Wiley & Sons A/S.

  15. Autotransporter genes pic and tsh are associated with Escherichia coli strains that cause acute pyelonephritis and are expressed during urinary tract infection.

    Science.gov (United States)

    Heimer, Susan R; Rasko, David A; Lockatell, C Virginia; Johnson, David E; Mobley, Harry L T

    2004-01-01

    We have identified two chromosomal open reading frames in uropathogenic Escherichia coli (UPEC) strain CFT073 which are highly homologous to serine protease autotransporters Pic and Tsh. Both cloned determinants were correlated with the presence of 105- to 110-kDa proteins in the culture supernatants. Furthermore, in cellular fractionation experiments, 30-kDa polypeptides were identified in the outer membrane; we speculated that these proteins are the beta-barrel portions of the autotransporter homologues. Furthermore, Pic-containing culture supernatants have serine protease activity. In reverse transcription-PCR analyses, the expression of the pic and tsh genes in E. coli CFT073 was higher in broth cultures grown at 37 degrees C than at 25 degrees C. Moreover, pic and tsh were expressed by bacteria isolated from urine of transurethrally infected mice. The tsh determinant was identified in 63% of our clinical UPEC strain isolates (n = 87) and in 33% of fecal strains (n = 27), whereas pic was present in 31% of the pyelonephritis (n = 67) and 7% of the fecal strains. There was no significant correlation between cystitis strains (n = 20) and the pic determinant.

  16. Development of a robust pH-sensitive polyelectrolyte ionomer complex for anticancer nanocarriers

    Directory of Open Access Journals (Sweden)

    Lim CM

    2016-02-01

    Full Text Available Chaemin Lim,1,* Yu Seok Youn,2,* Kyung Soo Lee,1 Ngoc Ha Hoang,1 Taehoon Sim,1 Eun Seong Lee,3 Kyung Taek Oh1 1Department of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University, Seoul, 2Department of Pharmaceutical Sciences, School of Pharmacy, Sungkyunkwan University, Suwon, 3Division of Biotechnology, The Catholic University of Korea, Gyeonggi-do, South Korea *These authors contributed equally to this work Abstract: A polyelectrolyte ionomer complex (PIC composed of cationic and anionic polymers was developed for nanomedical applications. Here, a poly(ethylene glycol–poly(lactic acid–poly(ethylene imine triblock copolymer (PEG–PLA–PEI and a poly(aspartic acid (P[Asp] homopolymer were synthesized. These polyelectrolytes formed stable aggregates through electrostatic interactions between the cationic PEI and the anionic P(Asp blocks. In particular, the addition of a hydrophobic PLA and a hydrophilic PEG to triblock copolyelectrolytes provided colloidal aggregation stability by forming a tight hydrophobic core and steric hindrance on the surface of PIC, respectively. The PIC showed different particle sizes and zeta potentials depending on the ratio of cationic PEI and anionic P(Asp blocks (C/A ratio. The doxorubicin (dox-loaded PIC, prepared with a C/A ratio of 8, demonstrated pH-dependent behavior by the deprotonation/protonation of polyelectrolyte blocks. The drug release and the cytotoxicity of the dox-loaded PIC (C/A ratio: 8 increased under acidic conditions compared with physiological pH, due to the destabilization of the formation of the electrostatic core. In vivo animal imaging revealed that the prepared PIC accumulated at the targeted tumor site for 24 hours. Therefore, the prepared pH-sensitive PIC could have considerable potential as a nanomedicinal platform for anticancer therapy. Keywords: polyelectrolyte ionomer complex, PEG–PLA–PEI, nanomedicine, pH-sensitive, animal imaging

  17. Una lectura crítica de De la Conquista a la Independencia de Mariano Picón Salas

    Directory of Open Access Journals (Sweden)

    Carlos García Miranda

    2011-05-01

    Full Text Available Afirma Guillermo Sucre que Mariano Picón Salas (Venezuela, 1901-1965 fue «un clarificador, un interprete, un ordenador». (Sucre, 1983:XLI Acertada caracterización para un pensador de talla continental,que confesó de manera intensa en el prólogo a la edición de sus obrascompletas lo siguiente:He hecho lo que pude en una vida que a los veinte años soñé sedentariay contemplativa y que se pobló de accidentes. Tampoco la literatura –suma consolación en los días malos– fue mi exclusivo oficio. He sidoprofesor con cariño por su cátedra; funcionario un poco indisciplinado yde petulantes iniciativas que a veces incomodaban a los jefes; diplomáticoeventual y periodista. Sobre todo he tenido una profesión diversificadae inconcebible para cualquier europeo o norteamericano aislado en surobinsónico islote especialista (Picón Salas, 1983: 8.Aspectos que muy bien pueden ser generalizados a otros pensadoreslatinoamericanos, como José Carlos Mariátegui –periodista, político,ideólogo, literato–, o José Martí –poeta, político, ideólogo. Laproducción intelectual de Picón Salas revela esta situación, habiendoescrito sobre literatura, política e historia, y dominado géneros comola autobiografía, el estudio y la investigación histórica.En este marco, el presente trabajo explora los alcances delplanteamiento de Mariano Picón Salas con respecto al tema del Barrococolonial. Para ello, de su amplia producción ensayística, nos abocaremosa realizar una lectura crítica de su libro De la conquista a la independencia (Picón Salas, 1995 [1944].

  18. Valores de energia metabolizável de alimentos para pintos de corte na fase pré-inicial Metabolizable energy values of feedstuffs for young chickens from pre-initial phase

    Directory of Open Access Journals (Sweden)

    Kamilla Ribas Soares

    2005-02-01

    Full Text Available Um experimento foi realizado no Setor de Avicultura da Universidade Federal de Lavras (UFLA, com duração de 6 dias, para determinar os valores energéticos de fontes protéicas para pintos de corte na fase pré-inicial. Utilizaram-se 480 pintos machos, Cobb, com 1 dia de idade que foram submetidos à metodologia de coleta total de excretas e distribuídos em 9 tratamentos com 6 repetições. Os tratamentos foram compostos por 4 alimentos protéicos de origem vegetal (farelo de soja, soja integral tostada, soja micronizada e farelo de glúten de milho que substituíram a ração referência (RR em 30% e 4 alimentos protéicos de origem animal (farinha de carne e ossos 40% e 45% de PB, farinha de peixe e farinha de vísceras, que substituíram a RR em 20%. Simultaneamente, 6 repetições de 8 aves foram colocadas em jejum para a determinação das perdas endógenas. As variáveis estudadas foram energia metabolizável aparente (EMA, verdadeira (EMV e as EMA e EMV corrigidas para balanço de nitrogênio (EMAn, EMVn. Os alimentos de origem vegetal obtiveram valores de energia inferiores aos obtidos nas tabelas usuais de composição dos alimentos e os alimentos de origem animal, valores superiores.An experiment was conducted in the Poultry Farm Sector of the Universidade Federal de Lavras (UFLA with 6 days period duration to determine the energy values in protein sources for broiler chickens in the pre-initial phase. A total of 480 male chickens from Cobb line with one day old were submitted to the method of total excreta collection, allotted to nine treatments with six replicates each. The experimental unit consisted of eight chickens. The treatments were: 1- reference diet (RD; 2- RD with the addition of soybean meal; 3- RD with the addition of toasted soybean meal; 4- RD with the addition of micronized soybean meal; 5- RD with corn gluten meal; 6- RD with meat and bone meal 40; 7 - RD meat and bone meal 45; 8 - RD with fish meat; 9- RD with

  19. Impact of the Interplanetary Magnetic Field rotation from North to South on the Alfven Transition Layer: 3D Global PIC Simulation

    Science.gov (United States)

    Cai, DongSheng; Lembege, Bertrand; Nishikawa, Ken-ichi

    2017-04-01

    Using a global 3D PIC simulation, the solar-terrestrial magnetosphere interaction has been analyzed focusing on the 3D magnetic cusp region. Our recent global simulation results (Cai et al., JGR 2015) have reproduced the main features of the magnetic cusp under a northward IMF configuration comparing with the three-year statistical observations of Cluster satellites (Lavraud et al., JGR, 2005). One of the most important features found in our simulation is the existence of the Alfven Transition Layer (ATL) where Alfven Mach number is nearly zero almost adjacent to the upper stagnant exterior cusp (SEC). Its width measured near the SEC within the meridian plane varies from 1 to 4 Re. From the magnetosheath to SEC, the plasma flows transit from super to sub-Alfvenic regime. Striking features observed in the simulation is the unique depleted funnel shape ATL starting from the high altitude dusk to low altitude dawn above the magnetic cusp in a northward IMF. Both the ion and electron flux enter and spiral into the cups region through this depleted ATL with possibly a curvature drift. Varying IMF from north to south through dusk-dawn direction, this ATL persists although it drastically shrinks. Especially, in the southward IMF, the ion flux enters into the cusp region through the complicated ATL and bounce back to the magnetosheath. ATL can help us to investigate the complex structures of the magnetic cusp.

  20. Pembangkit Ragam Gelombang Terprogram Menggunakan DDS AD9851 Berbasis Mikrokontroler PIC 18F4550

    Directory of Open Access Journals (Sweden)

    Hidayat Nur Isnianto

    2015-05-01

    Full Text Available Abstrak—Direct  Digital  Synthesizer  (DDS  merupakan  metode  pembangkit gelombang  analog  secara  digital  dengan  cara    membangkitkan sinyal  digital  yang  berubah-ubah  terhadap  waktu kemudian diubah  kedalam  bentuk analog  menggunakan digital  to  analog  converter  (DAC.  IC AD9851 merupakan  pembangkit  gelombang  analog  yang  menerapkan  metode  DDS, dimana frekuensi yang dibangkitkannya dapat diubah sesuai kebutuhan penggunanya. Untuk menghasilkan sinyal digital menggunakan mikrokontroler PIC 18F4550 karena mikrokontroler ini telah memiliki fitur USB full-speed  2.0  untuk  antarmuka dengan komputer  melalui  USB  tanpa memerlukan driver khusus untuk melakukan komunikasinya. Pengaturan frekuensi dapat dilakukan melalui tombol keypad ataupun diprogram melalui komputer. Hasil  pengujian pembangkit ragam gelombang ini  adalah  rentang frekuensi yang dihasilkan dari  1000  Hz  hingga  30 MHz  berupa gelombang  sinus dengan amplitudo 430 mV dan  gelombang  kotak dengan amplitudo 4,125 V. Kata  Kunci:  DDS,  AD9851,  PIC  18F4550,  USB,  Pembangkit Gelombang Abstract— Direct  Digital  Synthesizer  (DDS  is  a  method  to  generate  an  analog waveform in a digital manner, which is formed by generating a digital signal that varies with time and converted into analog form using a digital to analog device (DAC. IC AD9851 is an analog waveform generator to implements the DDS method, , which generates a frequency that can be changed according to the needs of its users.  To generate a digital signal using a PIC 18F4550 microcontroller microcontroller because it has a feature full-speed USB 2.0 to interface with the computer via USB without the need for special drivers to do the communication . Setting the output frequency can be done via the keypad or buttons programmed via computer . The test results are generating a wide range of frequency waves produced from 1000

  1. Numerical instability due to relativistic plasma drift in EM-PIC simulations

    Science.gov (United States)

    Xu, Xinlu; Yu, Peicheng; Martins, Samual F.; Tsung, Frank S.; Decyk, Viktor K.; Vieira, Jorge; Fonseca, Ricardo A.; Lu, Wei; Silva, Luis O.; Mori, Warren B.

    2013-11-01

    The numerical instability observed in electromagnetic particle-in-cell (EM-PIC) simulations with a plasma drifting with relativistic velocities is studied using both theory and computer simulations. We derive the numerical dispersion relation for a cold plasma drifting with a relativistic velocity, and find an instability attributed to the intersection between beam resonances and the electromagnetic modes in the drifting plasma. The intersection can occur in the fundamental Brillouin zones when EM waves with phase velocities less than the speed of light exist, and from aliasing beam resonances and aliasing EM modes. The unstable modes are neither purely transverse nor longitudinal. The characteristic patterns of the instability in Fourier space for various simulation setups and Maxwell equation solvers are explored by solving the corresponding numerical dispersion relations. Furthermore, based upon these characteristic patterns, we derive an asymptotic expression for the instability growth rate. The asymptotic expression greatly speeds up the calculation of the instability growth rate and makes the parameter scans for minimal growth rate feasible even for full three dimensions. The results are compared against simulation results, and good agreements are found. These results can be used as a guide to develop possible approaches to mitigate the instability. We examine the use of a spectral solver and show that such a solver when combined with a low pass filter with a cutoff value of |k→| essentially eliminates the instability while not modifying modes of physical interest. The use of a spectral solver also provides minimal errors to electromagnetic modes in the lowest Brillouin zones.

  2. Real time monitoring of ECG signal using PIC and web server

    Directory of Open Access Journals (Sweden)

    Saurabh Prakash

    2013-04-01

    Full Text Available This paper demonstrated the design of a wireless sensor network to monitor patients suffering from chronic diseases in their homes without regularly going to health center. Presently, most of themonitoring systems use personal computers (PC to send patient’s health data (ECG in this case to the hospital from patient’s home. Here, the idea is to eliminate the need of a PC thereby having a major cost reduction and still have a sustainable and effective system in place. The remote monitoring system consists of a WSN (wireless sensor network in which nodes are placed in a patient’s home. These nodes are connected to a central node which is installed at the hospital through an internet connection. The nodes of the WSN consists of ECG sensors, PIC microcontroller, CC2500 low power wireless radio. At first ECG signals are sampled by a portable device which is connected to patient to be monitored. The sampled signals are then transmitted wirelessly to an access point located in the patient’s home through a CC2500 which works at a frequency of 2.4GHz. The access point is then connected to the internet through digital subscriber line router. Later, the data collected are sent to the hospital via internet for storage and further analysis. This remote monitoring can be advantageous in several ways. It can significantly reduce the cost of the entire setup by eliminating the need of a PC. There is a reduction in time to send the data as the need of turning the PC on every time has been diminished.

  3. Double-cusp simulation during northward IMF using 3D PIC global code

    Science.gov (United States)

    Esmaeili, Amin; Kalaee, Mohammad Javad

    2017-07-01

    The cusp has important effects on the transportation of particles and their energy from the solar wind to the magnetosphere, and ionosphere, and high-altitude atmosphere. The cusp can be considered to be a part of the magnetospheric boundary layer with weaker magnetic fields. It has been studied since 1971 by different satellite observations. Despite many years of investigation, some problems, such as the boundaries, shapes, and method of construction, remain to be solved. The double cusp was first reported by Wing using the observation of the DMSP satellite. He also compared the results of observations with the results of a 2D MHD simulation. In this study, by performing simulations and analyzing the results, we report the observation of a V-shaped double-cusp structure under the northward Interplanetary Magnetic Field (IMF). In our simulation, the double cusp was seen only for electrons, although a weak double cusp was observed for ions as well. We showed that this double cusp occurred because of electron precipitation from different sources of solar wind and magnetosphere with different magnetic field strengths. In previous studies of the double cusp, there were debates on its spatial structure or on its temporal behavior due to the cusp movement caused by the sharp solar wind effects on the magnetosphere shape. Here we report the spatial detection of the double cusp similar to the one observed by the DMSP satellite, but for the northward IMF case. Also, we investigate the asymmetry along the dawn-dusk side of the magnetosphere using our 3D PIC simulation code.

  4. Global fully kinetic models of planetary magnetospheres with iPic3D

    Science.gov (United States)

    Gonzalez, D.; Sanna, L.; Amaya, J.; Zitz, A.; Lembege, B.; Markidis, S.; Schriver, D.; Walker, R. J.; Berchem, J.; Peng, I. B.; Travnicek, P. M.; Lapenta, G.

    2016-12-01

    We report on the latest developments of our approach to model planetary magnetospheres, mini magnetospheres and the Earth's magnetosphere with the fully kinetic, electromagnetic particle in cell code iPic3D. The code treats electrons and multiple species of ions as full kinetic particles. We review: 1) Why a fully kinetic model and in particular why kinetic electrons are needed for capturing some of the most important aspects of the physics processes of planetary magnetospheres. 2) Why the energy conserving implicit method (ECIM) in its newest implementation [1] is the right approach to reach this goal. We consider the different electron scales and study how the new IECIM can be tuned to resolve only the electron scales of interest while averaging over the unresolved scales preserving their contribution to the evolution. 3) How with modern computing planetary magnetospheres, mini magnetosphere and eventually Earth's magnetosphere can be modeled with fully kinetic electrons. The path from petascale to exascale for iPiC3D is outlined based on the DEEP-ER project [2], using dynamic allocation of different processor architectures (Xeon and Xeon Phi) and innovative I/O technologies.Specifically results from models of Mercury are presented and compared with MESSENGER observations and with previous hybrid (fluid electrons and kinetic ions) simulations. The plasma convection around the planets includes the development of hydrodynamic instabilities at the flanks, the presence of the collisionless shocks, the magnetosheath, the magnetopause, reconnection zones, the formation of the plasma sheet and the magnetotail, and the variation of ion/electron plasma flows when crossing these frontiers. Given the full kinetic nature of our approach we focus on detailed particle dynamics and distribution at locations that can be used for comparison with satellite data. [1] Lapenta, G. (2016). Exactly Energy Conserving Implicit Moment Particle in Cell Formulation. arXiv preprint ar

  5. 用AD7416+PIC16F84+PC机构建的测温系统%Temperature Measuring System Built up with AD7416+PIC16F84+PC

    Institute of Scientific and Technical Information of China (English)

    李学海; 董丹; 李建良

    2004-01-01

    全面系统地介绍带I2C总线接口的10位数字温度传感器AD7416和RISC型8位单片机PIC16F84,以及与PC机通信的硬件接线方法和软件算法设计,并且提供完整的PC端C程序和单片机端汇编语言程序.

  6. Study on the After Cavity Interaction in a 140 GHz Gyrotron Using 3D CFDTD PIC Simulations

    Science.gov (United States)

    Lin, M. C.; Illy, S.; Avramidis, K.; Thumm, M.; Jelonnek, J.

    2016-10-01

    A computational study on after cavity interaction (ACI) in a 140 GHz gryotron for fusion research has been performed using a 3-D conformal finite-difference time-domain (CFDTD) particle-in-cell (PIC) method. The ACI, i.e. beam wave interaction in the non-linear uptaper after the cavity has attracted a lot of attention and been widely investigated in recent years. In a dynamic ACI, a TE mode is excited by the electron beam at the same frequency as in the cavity, and the same mode is also interacting with the spent electron beam at a different frequency in the non-linear uptaper after the cavity while in a static ACI, a mode interacts with the beam both at the cavity and at the uptaper, but at the same frequency. A previous study on the dynamic ACI on a 140 GHz gyrotron has concluded that more advanced numerical simulations such as particle-in-cell (PIC) modeling should be employed to study or confirm the dynamic ACI in addition to using trajectory codes. In this work, we use a 3-D full wave time domain simulation based on the CFDTD PIC method to include the rippled-wall launcher of the quasi-optical output coupler into the simulations which breaks the axial symmetry of the original model employing a symmetric one. A preliminary simulation result has confirmed the dynamic ACI effect in this 140 GHz gyrotron in good agreement with the former study. A realistic launcher will be included in the model for studying the dynamic ACI and compared with the homogenous one.

  7. Elimination of the numerical Cerenkov instability for spectral EM-PIC codes

    Science.gov (United States)

    Yu, Peicheng; Xu, Xinlu; Decyk, Viktor K.; Fiuza, Frederico; Vieira, Jorge; Tsung, Frank S.; Fonseca, Ricardo A.; Lu, Wei; Silva, Luis O.; Mori, Warren B.

    2015-07-01

    When using an electromagnetic particle-in-cell (EM-PIC) code to simulate a relativistically drifting plasma, a violent numerical instability known as the numerical Cerenkov instability (NCI) occurs. The NCI is due to the unphysical coupling of electromagnetic waves on a grid to wave-particle resonances, including aliased resonances, i.e., ω + 2 πμ / Δt =(k1 + 2 πν1 / Δx1) v0, where μ and ν1 refer to the time and space aliases and the plasma is drifting relativistically at velocity v0 in the 1 ˆ -direction. We extend our previous work Xu et al. (2013) by recasting the numerical dispersion relation of a relativistically drifting plasma into a form which shows explicitly how the instability results from the coupling modes which are purely transverse electromagnetic (EM) modes and purely longitudinal modes in the rest frame of the plasma for each time and space aliasing. The dispersion relation for each μ and ν1 is the product of the dispersion relation of these two modes set equal to a coupling term that vanishes in the continuous limit. The new form of the numerical dispersion relation provides an accurate method of systematically calculating the growth rate and location of the mode in the fundamental Brillouin zone for any Maxwell solver for each μ and ν1. We then focus on the spectral Maxwell solver and systematically discuss its NCI modes. We show that the second fastest growing NCI mode for the spectral solver corresponds to μ =ν1 = 0, that it has a growth rate approximately one order of magnitude smaller than the fastest growing μ = 0 and ν1 = 1 mode, and that its location in the k space fundamental Brillouin zone is sensitive to the grid size and time step. Based on these studies, strategies to systematically eliminate the NCI modes for a spectral solver are developed. We apply these strategies to both relativistic collisionless shock and LWFA simulations, and demonstrate that high-fidelity multi-dimensional simulations of drifting plasmas can

  8. PIC16F84/627/628实验板电路的使用方法

    Institute of Scientific and Technical Information of China (English)

    丁锦滔

    2004-01-01

    电子制作杂志社和北京单片机协会,联合举办的PIC单片机函授学习班,其中配套的PIC实验编程器Ⅱ型中的PIC16F84/627/628实验板。因其可实验的功能较多,初学PIC单片机时。难于掌握其使用方法,这里加以较详细的介绍。

  9. 基于PIC16F84单片机的IC卡智能水表设计

    Institute of Scientific and Technical Information of China (English)

    李庆瑞; 袁魏华; 葛建峰

    2006-01-01

    本文介绍了一种基于低功耗芯片PIC16F84的IC卡智能水表的设计,文中给出了系统的硬件设计和软件设计。该IC卡水表具有低成本、低功耗、可靠性高等优点。可广泛应用于各城市供水系统。

  10. Resolution of the Vlasov-Maxwell system by PIC discontinuous Galerkin method on GPU with OpenCL

    Directory of Open Access Journals (Sweden)

    Crestetto Anaïs

    2013-01-01

    Full Text Available We present an implementation of a Vlasov-Maxwell solver for multicore processors. The Vlasov equation describes the evolution of charged particles in an electromagnetic field, solution of the Maxwell equations. The Vlasov equation is solved by a Particle-In-Cell method (PIC, while the Maxwell system is computed by a Discontinuous Galerkin method. We use the OpenCL framework, which allows our code to run on multicore processors or recent Graphic Processing Units (GPU. We present several numerical applications to two-dimensional test cases.

  11. Los Microcontroladores PIC16F877 y su aplicación en prácticas de laboratorio

    OpenAIRE

    Orozco Gallego, Hoover; Cortés Bermúdez, Carlos Alberto; Gallego Becerra, Hugo Armando

    2007-01-01

    En este artículo se quiere presentar un nuevo dispositivo para las prácticas de movimiento rectilíneo uniforme y movimiento uniformemente acelerado, prácticas que se realizan en los laboratorios de Física I y que generalmente se llevan a cabo con un carril de Fletcher, con un ticómetro o recurriendo a un carril de aire. Es de notar que para lograr los objetivos de este proyecto se hizo uso de un microcontrolador PIC16F877, quien se encarga de hacer el control de velocidades y aceler...

  12. Electromagnetic particle-in-cell (PIC) method for modeling the formation of metal surface structures induced by femtosecond laser radiation

    Energy Technology Data Exchange (ETDEWEB)

    Djouder, M. [Laboratoire de Physique et Chimie Quantique, Université Mouloud Mammeri de Tizi-ouzou, BP 17 RP, 15000 Tizi-Ouzou (Algeria); Lamrous, O., E-mail: omarlamrous@mail.ummto.dz [Laboratoire de Physique et Chimie Quantique, Université Mouloud Mammeri de Tizi-ouzou, BP 17 RP, 15000 Tizi-Ouzou (Algeria); Mitiche, M.D. [Laboratoire de Physique et Chimie Quantique, Université Mouloud Mammeri de Tizi-ouzou, BP 17 RP, 15000 Tizi-Ouzou (Algeria); Itina, T.E. [Laboratoire Hubert Curien, UMR CNRS 5516/Université Jean Monnet, 18 rue de Professeur Benoît Lauras, 42000 Saint-Etienne (France); Zemirli, M. [Laboratoire de Physique et Chimie Quantique, Université Mouloud Mammeri de Tizi-ouzou, BP 17 RP, 15000 Tizi-Ouzou (Algeria)

    2013-09-01

    The particle in cell (PIC) method coupled to the finite-difference time-domain (FDTD) method is used to model the formation of laser induced periodic surface structures (LIPSS) at the early stage of femtosecond laser irradiation of smooth metal surface. The theoretical results were analyzed and compared with experimental data taken from the literature. It was shown that the optical properties of the target are not homogeneous and the ejection of electrons is such that ripples in the electron density were obtained. The Coulomb explosion mechanism was proposed to explain the ripples formation under the considered conditions.

  13. Electromagnetic particle-in-cell (PIC) method for modeling the formation of metal surface structures induced by femtosecond laser radiation

    Science.gov (United States)

    Djouder, M.; Lamrous, O.; Mitiche, M. D.; Itina, T. E.; Zemirli, M.

    2013-09-01

    The particle in cell (PIC) method coupled to the finite-difference time-domain (FDTD) method is used to model the formation of laser induced periodic surface structures (LIPSS) at the early stage of femtosecond laser irradiation of smooth metal surface. The theoretical results were analyzed and compared with experimental data taken from the literature. It was shown that the optical properties of the target are not homogeneous and the ejection of electrons is such that ripples in the electron density were obtained. The Coulomb explosion mechanism was proposed to explain the ripples formation under the considered conditions.

  14. Controle de um pré-regulador com alto fator de potência utilizando microcontrolador PIC /

    OpenAIRE

    Grosse, Alexandre de Souza

    1999-01-01

    Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Estudo de controle digital em eletrônica de potência utilizando um microcontrolador especial PIC17C756 em um pré-regulador para correção ativa do fator de potência. O enfoque principal é dado no controle da malha de corrente do conversor elevador utilizado. Parte-se da caracterização do microcontrolador e seus periféricos e prossegue-se através do projeto do conversor BOOST. São apresentadas as técnicas de...

  15. Administration of a PTEN inhibitor BPV(pic) attenuates early brain injury via modulating AMPA receptor subunits after subarachnoid hemorrhage in rats.

    Science.gov (United States)

    Chen, Yujie; Luo, Chunxia; Zhao, Mingyue; Li, Qiang; Hu, Rong; Zhang, John H; Liu, Zhi; Feng, Hua

    2015-02-19

    The aim of this study was to investigate whether the phosphatase and tensin homolog deleted on chromosome ten (PTEN) inhibitor dipotassium bisperoxo(pyridine-2-carboxyl) oxovanadate (BPV(pic)) attenuates early brain injury by modulating α-amino-3-hydroxy-5-methyl-4-isoxa-zolep-propionate (AMPA) receptor subunits after subarachnoid hemorrhage (SAH). A standard intravascular perforation model was used to produce the experimental SAH in Sprague-Dawley rats. BPV(pic) treatment (0.2mg/kg) was evaluated for effects on neurological score, brain water content, Evans blue extravasation, hippocampal neuronal death and AMPA receptor subunits alterations after SAH. We found that BPV(pic) is effective in attenuating BBB disruption, lowering edema, reducing hippocampal neural death and improving neurological outcomes. In addition, the AMPA receptor subunit GluR1 protein expression at cytomembrane was downregulated, whereas the expression of GluR2 and GluR3 was upregulated after BPV(pic) treatment. Our results suggest that PTEN inhibited by BPV(pic) plays a neuroprotective role in SAH pathophysiology, possibly by alterations in glutamate AMPA receptor subunits.

  16. The design of EtherCAT slave interface based on PIC18F4520%运用PIC18F4520的EtherCAT从站接口电路的设计

    Institute of Scientific and Technical Information of China (English)

    康存锋; 李琛玫; 庞艳; 马春敏; 黄旭东

    2012-01-01

    Based on introducing the operational principles and communication protocols of EtherCAT real-time industrial Eethernet technology, designed and developed a slave interface circuit using the PIC18F4520 single chip as a processor, operating ET1100 chip. In order to be extended and facilitate the selection of the transmission medium, the circuit uses standard Ethernet physical layer interface (Mil interface) and SPI communication, completing the data link layer connection, to achieve the basic communication of EtherCAT. It verifies the interface circuit meets the EtherCAT communication protocol requirements by Wireshark software.%在介绍EtherCAT实时工业以太网技术的工作原理和通信协议的基础上,设计开发了一个使用PIC18F4520单片机作为处理器操作ET1100芯片的从站接口电路.为了可扩展和方便选用传输介质,电路采用标准的以太网物理接口(MII接口)和SPI通信方式,完成数据链路层的连接,实现了EtherCAT基本通信.通过Wireshark软件验证了此接口电路符合EtherCAT通信协议要求.

  17. 基于PIC18F的医疗超声诊断仪备用逆变电源研制%Research and Development of Reserve Inverter of Medical Ultrasonic Diagnostic Equipment Based on PIC18F

    Institute of Scientific and Technical Information of China (English)

    徐健; 杨亚琴

    2012-01-01

    Reserve inverter which used the PIC18F1330 processor as the core controller adopts the inversion mode of AC - DC - AC and produces SPWM running signals for the inversion currency. In the meanwhile the in- verter runs such protective functions its voltage stabilization, over - voltage, and under - voltage and temperature protection. The designed reserve inve:rter is characterized as stable voltage and few aberratiorLs and has been proved to be very practical since it has confirmed the medical ultrasonic diagnostic equipment emergency generator require- ments.%逆变电源采用AC-DC-AC可控整流加单相逆变的变换模式,以PIC18F1330处理器作为核心控制器件,产生逆变电路所需的SPWM驱动信号,同时完成稳压、过压保护、欠压保护、过载保护及温度保护等功能。所设计的备用逆变电源具有电压稳定、畸变小等特点,经实际使用符合医疗超声诊断仪等医疗设备应急供电的要求,具有很高的实用价值。

  18. 基于PIC32的居室智能化平台的设计与实现%Information System for Smart Home Based on PIC32

    Institute of Scientific and Technical Information of China (English)

    张庆磊; 王珍珍; 王传刚; 杨亮

    2015-01-01

    系统以PIC32单片机作为核心控制器,植入TCP/IP通信协议和文件系统,通过WiFi模块和无线网络可实时访问存储在SD卡设备文件中的系统参数和传感数据,并能进行参数的配置和数据的管理,进而实现智能家居系统的远程监控、管理和控制。系统可通过个人电脑或手机进行访问,具有较好的人机交互功能,方便易用,功能可扩展性强,且设计运行成本低。%The designed system uses PIC32 MCU as the core controller with embedded TCP/IP communication protocols and file system.WiFi module can be used to access system parameters and sensors'data stored in the SD card through a wireless network.The device parameters can be configured with data management for monitoring or control of the status of intelligent household system.The system can be conveniently accessed through personal com-puters or mobile phones.The system also has advantages of good scalability and low design and running cost.

  19. 基于PIC16F685的低功耗倾角测量仪的设计%Design of low-power angle measurement instrument based on PIC16F685

    Institute of Scientific and Technical Information of China (English)

    刘建航; 秦思思; 赵峰印

    2014-01-01

    This paper designs a new kind of angle measuring device,for the measurement of the angle measuring instrument is not accurate and large power consumption and so on. It is based on PIC16F685 MCU as the main control chip, using ADXL345 digital sensor triaxial acceleration speed meter to measure angle, and using the LCD to display the measured data. Through high-quality algorithm, the measuring accuracy of angle measuring instrument is greatly increased and the accuracy is within ± 0.5° and power consumption is lower. It will have a better actual application effect.%针对目前倾角测量仪测量精度差、功耗较大等缺点,设计了一种新型的倾角测量装置。该低功耗倾角测量仪以 PIC16F685单片机为主控芯片,利用 ADXL345数字式传感器三轴加速度测速计测量倾角,采用 LCD液晶显示所测数据。通过优质算法使倾角测量仪的测量精度大大提高,使精度误差在±0.5°之内,并且功耗较低,在实际应用中效果较好。

  20. To build an environmental quality building. Evaluation: the HQE secondary school of Pic Saint Loup realized by the region; Construire un batiment respectueux de l'environnement. Retour d'experience: le Lycee HQE du Pic Saint Loup realise par la Region

    Energy Technology Data Exchange (ETDEWEB)

    Denicourt, Ch.

    2004-07-01

    This document presents the action realized in Pic Saint Loup secondary school, concerning the program management of an environmental quality building (HQE). The 8 chapters details the realization of the HQE building, the project planing of a HQE building, the Pic Saint Loup project, the operation beginning, the planing implementing, the project feasibility evaluation, the program redaction and the time and cost evaluation. (A.L.B.)

  1. Specificity-Determining DNA Triplet Code for Positioning of Human Preinitiation Complex.

    Science.gov (United States)

    Goldshtein, Matan; Lukatsky, David B

    2017-05-23

    The notion that transcription factors bind DNA only through specific, consensus binding sites has been recently questioned. No specific consensus motif for the positioning of the human preinitiation complex (PIC) has been identified. Here, we reveal that nonconsensus, statistical, DNA triplet code provides specificity for the positioning of the human PIC. In particular, we reveal a highly nonrandom, statistical pattern of repetitive nucleotide triplets that correlates with the genomewide binding preferences of PIC measured by Chip-exo. We analyze the triplet enrichment and depletion near the transcription start site and identify triplets that have the strongest effect on PIC-DNA nonconsensus binding. Using statistical mechanics, a random-binder model without fitting parameters, with genomic DNA sequence being the only input, we further validate that the nonconsensus nucleotide triplet code constitutes a key signature providing PIC binding specificity in the human genome. Our results constitute a proof-of-concept for, to our knowledge, a new design principle for protein-DNA recognition in the human genome, which can lead to a better mechanistic understanding of transcriptional regulation. Copyright © 2017 Biophysical Society. Published by Elsevier Inc. All rights reserved.

  2. Constitutive turnover of histone H2A.Z at yeast promoters requires the preinitiation complex.

    Science.gov (United States)

    Tramantano, Michael; Sun, Lu; Au, Christy; Labuz, Daniel; Liu, Zhimin; Chou, Mindy; Shen, Chen; Luk, Ed

    2016-07-20

    The assembly of the preinitiation complex (PIC) occurs upstream of the +1 nucleosome which, in yeast, obstructs the transcription start site and is frequently assembled with the histone variant H2A.Z. To understand the contribution of the transcription machinery in the disassembly of the +1 H2A.Z nucleosome, conditional mutants were used to block PIC assembly. A quantitative ChIP-seq approach, which allows detection of global occupancy change, was employed to measure H2A.Z occupancy. Blocking PIC assembly resulted in promoter-specific H2A.Z accumulation, indicating that the PIC is required to evict H2A.Z. By contrast, H2A.Z eviction was unaffected upon depletion of INO80, a remodeler previously reported to displace nucleosomal H2A.Z. Robust PIC-dependent H2A.Z eviction was observed at active and infrequently transcribed genes, indicating that constitutive H2A.Z turnover is a general phenomenon. Finally, sites with strong H2A.Z turnover precisely mark transcript starts, providing a new metric for identifying cryptic and alternative sites of initiation.

  3. Reaching sub-milimag photometric precision on Beta Pictoris with a nanosat: the PicSat mission

    CERN Document Server

    Nowak, M; Lapeyrère, V; David, L; Crouzier, A; Dufoing, C; Faiz, H; Lemoult, T; Trebuchet, P

    2016-01-01

    PicSat is a nanosatellite currently being developed to observe the transit of the giant planet \\b{eta} Pictoris, expected some time between July 2017 and June 2018. The mission is based on a Cubesat architecture, with a small but ambitious 2 kg opto-mechanical payload specifically designed for high precision photometry. The satellite will be launched in early 2017, probably on a 600 km Sun synchronous orbit. The main objective of the mission is the constant monitoring of the brightness of Pic at an unprecedented combination of reliability and precision (200 ppm per hour, with interruptions of at most 30 minutes) to finely characterize the transiting exoplanet and detect exocomets in the Pictoris system. To achieve this difficult objective, the payload is designed with a 3.5 cm effective aperture telescope which injects the light in a single-mode optical fiber linked to an avalanche photodioode. A two-axis piezoelectric actuation system, driven by a tailor-made feedback loop control algorithm, is used to lock ...

  4. PIC microcontroller timing circuit applied research%PIC单片机定时电路的应用研究

    Institute of Scientific and Technical Information of China (English)

    李小琴

    2012-01-01

    Based on the PIC16F74 microcontroller and the DS1302 clock chip research,design a timer circuit,the circuit has a real-time display,the school,there are five timer setting function,the application in a rice cooker unattended,it can automatically startup and shutdown,to people's lives is a big convenience.%通过对单片机PIC16F74和时钟芯片DS1302的研究,设计了定时器电路。结果表明,该定时器电路具有实时显示、校时以及5个定时设置功能。该定明器应用在电饭煲等电器上时,可自动启动和关闭,给人们的生活带来了很大的便利。

  5. Reaching sub-milimag photometric precision on Beta Pictoris with a nanosat: the PicSat mission

    Science.gov (United States)

    Nowak, M.; Lacour, S.; Lapeyrère, V.; David, L.; Crouzier, A.; Dufoing, C.; Faiz, H.; Lemoult, T.; Trébuchet, P.

    2016-07-01

    PicSat is a nanosatellite currently being developed to observe the transit of the giant planet β Pictoris, expected some time between July 2017 and June 2018. The mission is based on a Cubesat architecture, with a small but ambitious 2 kg opto-mechanical payload specifically designed for high precision photometry. The satellite will be launched in early 2017, probably on a 600 km Sun synchronous orbit. The main objective of the mission is the constant monitoring of the brightness of Pic at an unprecedented combination of reliability and precision (200 ppm per hour, with interruptions of at most 30 minutes) to finely characterize the transiting exoplanet and detect exocomets in the Pictoris system. To achieve this difficult objective, the payload is designed with a 3.5 cm effective aperture telescope which injects the light in a single-mode optical fiber linked to an avalanche photodioode. A two-axis piezoelectric actuation system, driven by a tailor-made feedback loop control algorithm, is used to lock the fiber on the center of the star in the focal plane. These actuators complement the attitude determination and control system of the satellite to maintain the sub-arcsecond pointing accuracy required to reach the excellent level of photometric precision. Overall, the mission raises multiple very difficult challenges: high temperature stability of the avalanche detector (achieved with a thermoelectric colling device), high pointing accuracy and stability, and short timeframe for the development.

  6. Univerzální vývojová deska pro mikrokontrolery řady Pic18F

    OpenAIRE

    2009-01-01

    Tato práce popisuje návrh univerzální vývojové desky pro různé typy mikrokontrolérů a jednotného rozhraní pro modul mikrokontroléru k desce. Věnuje se jak popisu rozhraní a návrhu, tak také přehledu mikrokontrolérů Microchip PIC, použitelných s vývojovou deskou a vlastnostem typu PIC 18F4550. Práce dále zmiňuje podobné typy ostatních výrobců. Práce uvádí návrh vývojové desky a jejích komponent od blokového schéma přes schéma zapojení až k návrhu desek plošných spojů a vytvoření 3D modelů dese...

  7. SMILEI: A collaborative, open-source, multi-purpose PIC code for the next generation of super-computers

    Science.gov (United States)

    Grech, Mickael; Derouillat, J.; Beck, A.; Chiaramello, M.; Grassi, A.; Niel, F.; Perez, F.; Vinci, T.; Fle, M.; Aunai, N.; Dargent, J.; Plotnikov, I.; Bouchard, G.; Savoini, P.; Riconda, C.

    2016-10-01

    Over the last decades, Particle-In-Cell (PIC) codes have been central tools for plasma simulations. Today, new trends in High-Performance Computing (HPC) are emerging, dramatically changing HPC-relevant software design and putting some - if not most - legacy codes far beyond the level of performance expected on the new and future massively-parallel super computers. SMILEI is a new open-source PIC code co-developed by both plasma physicists and HPC specialists, and applied to a wide range of physics-related studies: from laser-plasma interaction to astrophysical plasmas. It benefits from an innovative parallelization strategy that relies on a super-domain-decomposition allowing for enhanced cache-use and efficient dynamic load balancing. Beyond these HPC-related developments, SMILEI also benefits from additional physics modules allowing to deal with binary collisions, field and collisional ionization and radiation back-reaction. This poster presents the SMILEI project, its HPC capabilities and illustrates some of the physics problems tackled with SMILEI.

  8. Univerzální vývojová deska pro mikrokontrolery řady Pic18F

    OpenAIRE

    Jež, David

    2009-01-01

    Tato práce popisuje návrh univerzální vývojové desky pro různé typy mikrokontrolérů a jednotného rozhraní pro modul mikrokontroléru k desce. Věnuje se jak popisu rozhraní a návrhu, tak také přehledu mikrokontrolérů Microchip PIC, použitelných s vývojovou deskou a vlastnostem typu PIC 18F4550. Práce dále zmiňuje podobné typy ostatních výrobců. Práce uvádí návrh vývojové desky a jejích komponent od blokového schéma přes schéma zapojení až k návrhu desek plošných spojů a vytvoření 3D modelů dese...

  9. Inertial electrostatic confinement and DD fusion at interelectrode media of nanosecond vacuum discharge. PIC simulations and experiment

    Science.gov (United States)

    Kurilenkov, Yu K.; Tarakanov, V. P.; Skowronek, M.; Guskov, S. Yu; Dufty, J.

    2009-05-01

    The generation of energetic ions and DD neutrons from microfusion at the interelectrode space of a low-energy nanosecond vacuum discharge has been demonstrated recently [1, 2]. However, the physics of fusion processes and some results regarding the neutron yield from the database accumulated were poorly understood. The present work presents a detailed particle-in-cell (PIC) simulation of the discharge experimental conditions using a fully electrodynamic code. The dynamics of all charge particles was reconstructed in time and anode-cathode (AC) space. The principal role of a virtual cathode (VC) and the corresponding single and double potential wells formed in the interelectrode space are recognized. The calculated depth of the quasistationary potential well (PW) of the VC is about 50-60 keV, and the D+ ions being trapped by this well accelerate up to energy values needed to provide collisional DD nuclear synthesis. The correlation between the calculated potential well structures (and dynamics) and the neutron yield observed is discussed. In particular, ions in the potential well undergo high-frequency (~80 MHz) harmonic oscillations accompanied by a corresponding regime of oscillatory neutron yield. Both experiment and PIC simulations illustrate favorable scaling of the fusion power density for the chosen IECF scheme based on nanosecond vacuum discharge.

  10. Stealth fast photoswitching of negative photochromic naphthalene-bridged phenoxyl-imidazolyl radical complexes.

    Science.gov (United States)

    Mutoh, Katsuya; Kobayashi, Yoichi; Hirao, Yasukazu; Kubo, Takashi; Abe, Jiro

    2016-05-21

    Naphthalene-bridged phenoxyl-imidazolyl radical complex (Np-PIC) is a novel fast switchable negative photochromic compound, which shows the thermal back reaction in the millisecond time scale. Upon UV light irradiation, Np-PIC shows the hypochromic effect in the UVA region due to there being less conjugation in the transient isomer. By replacing the phenoxyl unit with a naphthoxyl unit, the molecular structure has an asymmetric carbon, leading to fast chiroptical switching. This simple molecular design will be a good candidate for the future development of negative photochromic compounds.

  11. THERMOSENSITIVE POLYION COMPLEX MICELLES PREPARED BY SELF-ASSEMBLY OF TWO OPPOSITELY CHARGED DIBLOCK COPOLYMERS

    Institute of Scientific and Technical Information of China (English)

    Pan He; Chang-wen Zhao; Chun-sheng Xiao; Zhao-hui Tang; Xue-si Chen

    2013-01-01

    Polyion complex (PIC) micelles were spontaneously formed in aqueous solutions through electrostatic interaction between two oppositely charged block copolymers,poly(N-isopropylacrylamide)-b-poly(L-glutamic acid) and poly(N-isopropylacrylamide)-b-poly(L-lysine).Their controlled synthesis was achieved via the ring opening polymerization of N-carboxyanhydrides (NCA),ε-benzyloxycarbonyl-L-lysine (Lys(Z)-NCA) or γ-benzyl-L-glutamate (BLG-NCA) with amino-terminated poly(N-isopropylacrylamide) macroinitiator and the subsequent deprotection reaction.The formation of PIC micelles was confirmed by dynamic light scattering and transmission electron microscopy.Turbidimetric characterization suggested that the formed PIC micelles had a concentration-dependent thermosensitivity and their phase transition behaviors could be easily adjusted either by the block length of coplymers or the concentration of micelles.

  12. Numerical Studies of Optimization and Aberration Correction Methods for the Preliminary Demonstration of the Parametric Ionization Cooling (PIC) Principle in the Twin Helix Muon Cooling Channel

    CERN Document Server

    Maloney, J A; Derbenev, Ya S; Afanasev, A; Johnson, R P; Ankenbrandt, C A; Yoshikawa, C; Yonehara, K; Neuffer, D; Erdelyi, B

    2014-01-01

    Muon colliders have been proposed for the next generation of particle accelerators that study high-energy physics at the energy and intensity frontiers. In this paper we study a possible implementation of muon ionization cooling, Parametric-resonance Ionization Cooling (PIC), in the twin helix channel. The resonant cooling method of PIC offers the potential to reduce emittance beyond that achievable with ionization cooling with ordinary magnetic focusing. We examine optimization of a variety of parameters, study the nonlinear dynamics in the twin helix channel and consider possible methods of aberration correction.

  13. Diseño y desarrollo de un simulador de adquisición de entradas digitales y actuadores basado en microcontrolador PIC

    OpenAIRE

    Páez Espinosa, Alejandro Daniel

    2013-01-01

    El proyecto final de carrera consistirá en el diseño y desarrollo de un simulador de adquisición de entradas digitales gestionada mediante de comunicación puerto serie y Ethernet mediante protocolo UDP. El servicio UDP estará basado en microcontrolador PIC18F mediante el modulo ENC28J60. En este proyecto asimismo se realiza el diseño de un controlador (API) que emulará los drivers de la tarjeta basada en PIC18F y que abstraerá la lógica de bajo nivel, siendo posible su ut...

  14. Design of TV Tracking System Based on PIC16F84%基于PIC16F84的电视机智能跟踪系统设计

    Institute of Scientific and Technical Information of China (English)

    林刚; 田二虎

    2010-01-01

    介绍了一种基于PIC16F84的电视机智能跟踪系统的设计.该系统主要功能是自动记录电视机使用情况的有关数据(如电视通电时间、工作时同、使用次数等),为生产厂家提供电视产品的改进和升级换代需要的数据资料.该系统具有成本低、功耗低、可靠性强等优点.

  15. Design of High Power BLDC Motor Controller Based on dsPIC30F6010A%基于dsPIC30F6010A的大功率BLDC电机控制系统设计

    Institute of Scientific and Technical Information of China (English)

    郭本振; 杨晶晶; 郝尚富; 刘钰

    2013-01-01

    设计了一款以dsPIC30F6010A为核心的1.5kW大功率BLDC(无刷直流)电机控制系统.采用霍尔传感器确定转子位置并用来测速,利用IPM(智能功率模块)实现电机驱动.控制器具有CAN总线通讯接口,可以接收上层控制器发来的速度指令,采用积分分离的PID控制算法实现电机速度闭环控制.测试表明,系统运行稳定、可靠.

  16. 基于PIC18F4550的USB-CAN总线通信模块设计%Design of USB-CAN communication module based on PIC18F4550

    Institute of Scientific and Technical Information of China (English)

    吴从中; 彭维; 陈玮

    2010-01-01

    文章针对CAN总线和PC之间的通信"瓶颈"问题,提出了一种USB-CAN的转换通信模块,采用单片机PIC18F4550以及CAN总线控制器MCP2515和高速CAN收发器MCP2551来实现;介绍了各个模块之间的硬件接口电路,同时对固件编程以及USB驱动程序的设计进行了详细分析,目前该模块已成功应用于电脑横机控制系统中.

  17. Study on application of designing CAN bus using PIC18F248 chip%PIC18F248芯片在CAN总线设计中的应用

    Institute of Scientific and Technical Information of China (English)

    孙双花; 曲兴华; 杨学友; 叶声华

    2004-01-01

    CAN总线因为其突出的可靠性、实时性和灵活性等特点被广泛应用于分布式网络系统中.在基于CAN总线的分布式分层网络控制系统中,利用带有CAN接口的高性能的PIC18F248单片机设计了CAN总线接口,给出了CAN接口的硬件电路及软件流程.该电路具有硬件设计简单、可靠性高、实时性强等特点.

  18. 基于PIC18F248的SPWM波生成的一种方法%A Method of Producing SPWM Waveform Based on PIC18F248

    Institute of Scientific and Technical Information of China (English)

    代玉伟; 李敬东; 唐跃进; 石晶

    2007-01-01

    随着超导技术和电力电子技术的发展,三相电流源型变流器(CSC)在超导储能领域依然占有主导地位.文中详细地介绍了电流型变流器(CSC)的正弦脉宽调制方法.该方法利用MCU PIC18F248产生SPWM波,采用查表和在线计算相结合,既能满足一定控制精度,又能满足实时控制要求,同时给出了整个程序流程图.实验结果验证了该方法的正确性和可行性.

  19. 基于 PIC16 F883的高温注汽井温度压力测试仪的研制%High temperature gas injection temperature and pressure tester based on PIC16 F883

    Institute of Scientific and Technical Information of China (English)

    赵超

    2014-01-01

    In order to more accurately test of high temperature gas injector formation temperature and pressure data , a high temperature double parameter tester is developed .The instrument was composed of downhole instruments and ground processing: the downhole instrument completed the borehole tempera-ture, pressure, CCL of the collection and storage with PIC16F883 MCU as the core; Ground processing achieved downhole data playback and processing .This article introduces the structure of the instrument and the main technical indicators , the system hardware and software design .Application shows that the instrument can meet the testing requirements of the high temperature gas injector .%为了更准确地测试高温注汽井的地层温度、压力数据,研制了一种高温注汽井温度压力测试仪。该仪器由井下仪器与地面处理两个部分组成:井下仪器以PIC16 F883单片机为核心,完成井内温度、压力、磁定位的采集和存储;地面处理实现井下数据的回放与处理。介绍了该仪器的结构和主要技术指标、系统的硬件及软件设计。应用情况表明,该仪器能够满足高温注汽井的测试要求。

  20. Design of automobile electric power steering system based on PIC18F458%基于 PIC18 F458的汽车电动助力转向控制系统设计

    Institute of Scientific and Technical Information of China (English)

    苏庆列; 王麟珠

    2015-01-01

    针对国内汽车电动助力转向系统( EPS)的发展现状和性能要求,基于PIC18F458系列单片机对EPS系统电控单元软硬件进行设计,着重阐述了方向盘扭矩传感器信号采集和带有CAN总线的信息采集模块,以及通过全控桥电机驱动电路实现的PWM脉宽调制永磁无刷直流电机控制模块的工作原理及其实现方法。试验结果表明该电控单元工作正常、性能可靠,满足汽车助力转向的舒适性和安全性要求。%According to the domestic development status and performance requirements of electric power steering system ( EPS) , the software and hardware of electronic control unit of EPS is designed based on PIC18F458 Series MCU.Focuses on the principle and realization method of the information acquisition module that contains steering wheel torque sensor signals and the information of CAN Bus, and the control module of permanent magnet brushless DC motor which drives by fully controlled bridge circuit.The experimental results show that the electronic control unit works normally and reliably, comfort and safety meets the requirements of automotive power steering.

  1. 基于PIC18F65K90的低功耗数字压力表设计%The design of low power digital pressure gauge based on PIC18F65K90

    Institute of Scientific and Technical Information of China (English)

    钱鹏; 秦会斌

    2015-01-01

    To improve accuracy of the Digital pressure gauge while ensuring its stability and reducing further power consumption. In addition to the normal operating mode, it uses Low-power mode of PIC18F65K90 single chip processor with its sleep mode when designing digital pressure gauge. It is not available in general. Mainly from two aspects of hardware circuit testing and debugging software language, it introduces merits of the selected hardware devices in detail and functions of digital pressure gauge by describing the software algorithm. It is proved that these methods can achieve the expected accuracy and power through comparing with the standard gauge experiments.%基于保证数字压力表工作状态稳定性的同时要提高精度的目的,另外基于进一步降低功耗的目的,在设计压力表时,除了有常规的工作模式,还采用了PIC18F65K90单片机的休眠模式增加一种低功耗模式方法,这是大部分数字压力表不具备的。主要是从硬件电路检测和软件语言调试两个方面进行,详细介绍了各个选取到的硬件器件的优点,并且通过对软件算法的描述介绍了数字压力表各个功能的实现。通过与标准压力表对比获取数据的实验,测试最终的精度以及功耗,最终结果能够达到设计目标。

  2. Research on Protection Device for Inrush Current Control Based on PIC16F716%基于PIC16F716的涌流控制保护装置的研究

    Institute of Scientific and Technical Information of China (English)

    文化宾; 宋永端; 张自民; 潘永成

    2011-01-01

    When the circuit breaker is switched on, one large on-off inrush current would be generated. If the peak value of this inrush current is larger than the setting value of the over-current protection or value of the instantaneous trip protection, it would cause unwanted operation of the protection device and also lead to the failure of the closing operation. This paper designed one kind of protection device based on the PIC16F716 to realize the inrush current control function. When the inrush current occurs, the designed device would disable the protection, while when over-current or short-circuit faults happens, the device's protection would.be enabled, and then the circuit breaker would trip. This operating principle would reduce the times of the unwanted operations, and improve the power distribution reliability.%断路器合闸瞬间,会产生较大的涌流.如果涌流值超过了过流或者速断保护的整定值,就可能会导致保护误动,造成合闸失败.设计了一种基于PIC16F716单片机的涌流控制保护装置,当涌流发生时,将保护闭锁,当发生过流、短路等故障时,执行保护功能,断路器跳闸.从而减少保护误动,提高供电可靠性.

  3. 基于PIC16F84单片机的IC卡智能水表设计

    Institute of Scientific and Technical Information of China (English)

    王帅

    2013-01-01

    目前市面上采用的水表多需要人工抄表,然后由管理员上门收取水费或由管理部门通知用户到指定地点缴费,这种传统水表的工作模式存在耗时、耗力、低效率等不可避免的问题.而以PIC 16F84单片机为核心设计实现的智能水表,替代了大量人力,实现了用水管理的现代化,该设计成本低,可靠性好,易于在社会上推广,具有很好的市场潜力.

  4. A hybrid VOF and PIC multi-material interface treatment method and its application in the penetration

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    A hybrid VOF and PIC multi-material interface treatment method for Eulerian method is presented in this study in order to solve the problem that the Eulerian method is not robust enough to treat the dynamic fracture of material. This treatment method is used in the important computational region such as the material interface,large deformation region and fracture region where more particles are added for calculation,while the continuous transport method is used in the other regions. Through this method,a series of penetration problems such as blunt projectile penetration into the steel target and steel projectile penetration into concert target are numerically simulated. The comparison of the numerical result and experimental result shows that the hybrid algorithm can effectively track the deformation in the process of penetration and also insure precision and efficiency.

  5. Development of a Time-resolved Neutron Imaging Detector Based on the {\\mu}PIC Micro-Pixel Chamber

    CERN Document Server

    Parker, Joseph D; Hattori, Kaori; Iwaki, Satoru; Kabuki, Shigeto; Kishimoto, Yuji; Kubo, Hidetoshi; Kurosawa, Shunsuke; Matsuoka, Yoshihiro; Miuchi, Kentaro; Mizumoto, Tetsuya; Nishimura, Hironobu; Oku, Takayuki; Sawano, Tatsuya; Shinohara, Takenao; Suzuki, Jun-ichi; Takada, Atsushi; Tanimori, Toru; Ueno, Kazuki; Ikeno, Masahiro; Tanaka, Manobu; Uchida, Tomohisa

    2013-01-01

    We have developed a prototype time-resolved neutron imaging detector employing a micro-pattern gaseous detector known as the micro-pixel chamber ({\\mu}PIC) coupled with a field-programmable-gate-array-based data acquisition system. Our detector system combines 100{\\mu}m-level spatial and sub-{\\mu}s time resolutions with a low gamma sensitivity of less than 10^-12 and high data rates, making it well suited for applications in neutron radiography at high-intensity, pulsed neutron sources. In the present paper, we introduce the detector system and present several test measurements performed at NOBORU (BL10), J-PARC to demonstrate the capabilities of our prototype. We also discuss future improvements to the spatial resolution and rate performance.

  6. The Value of PIC Cystography in Detecting De Novo and Residual Vesicoureteral Reflux after Dextranomer/Hyaluronic Acid Copolymer Injection

    Directory of Open Access Journals (Sweden)

    B. W. Palmer

    2011-01-01

    Full Text Available The endoscopic injection of Dx/HA in the management of vesicoureteral reflux (VUR has become an accepted alternative to open surgery. In the current study we evaluated the value of cystography to detect de novo contralateral VUR in unilateral cases of VUR at the time of Dx/HA injection and correlated the findings of immediate post-Dx/HA injection cystography during the same anesthesia to 2-month postoperative VCUG to evaluate its ability to predict successful surgical outcomes. The current study aimed to evaluate whether an intraoperatively performed cystogram could replace postoperative studies. But a negative intraoperative cystogram correlates with the postoperative study in only 80%. Considering the 75–80% success rate of Dx/HA implantation, the addition of intraoperative cystograms cannot replace postoperative studies. In patients treated with unilateral VUR, PIC cystography can detect occult VUR and prevent postoperative contralateral new onset of VUR.

  7. The Value of PIC Cystography in Detecting De Novo and Residual Vesicoureteral Reflux after Dextranomer/Hyaluronic Acid Copolymer Injection.

    Science.gov (United States)

    Palmer, B W; Hemphill, M; Wettengel, K; Kropp, B P; Frimberger, D

    2011-01-01

    The endoscopic injection of Dx/HA in the management of vesicoureteral reflux (VUR) has become an accepted alternative to open surgery. In the current study we evaluated the value of cystography to detect de novo contralateral VUR in unilateral cases of VUR at the time of Dx/HA injection and correlated the findings of immediate post-Dx/HA injection cystography during the same anesthesia to 2-month postoperative VCUG to evaluate its ability to predict successful surgical outcomes. The current study aimed to evaluate whether an intraoperatively performed cystogram could replace postoperative studies. But a negative intraoperative cystogram correlates with the postoperative study in only 80%. Considering the 75-80% success rate of Dx/HA implantation, the addition of intraoperative cystograms cannot replace postoperative studies. In patients treated with unilateral VUR, PIC cystography can detect occult VUR and prevent postoperative contralateral new onset of VUR.

  8. El Cura Juan Fernández de Sotomayor y Picón y los catecismos de la Independencia

    OpenAIRE

    Ocampo López, Javier

    2010-01-01

    Este libro presenta el entorno revolucionario de finales del siglo XVIII y primera mitad del siglo XIX, a través del pensamiento y la acción del cura cartagenero Juan Fernández de Sotomayor y Picón, Cura de Mompós y rector del colegio Mayor de Nuestra Señora del Rosario, quien vivió en los años que dieron nacimiento a la República de Colombia. Se desempeñó como cura revolucionario, como político de Mompós, de Cartagena de Indias, ante el Congreso de las Provincias Unidas del Congreso Nacional...

  9. On the energy conservation electrostatic PIC/MC simulating: benchmark and application to the radio frequency discharges

    CERN Document Server

    Hong-Yu, Wang; Peng, Sun; Ling-Bao, Kong

    2014-01-01

    We benchmark and analyze the error of energy conservation (EC) scheme for particle in cell/Monte-Carlo Couple (PIC/MCC) algorithms by a radio frequency discharging simulation. The plasma heating behaviors and electron distributing functions obtained by 1D simulation are analyzed. Both explicit and implicit algorithms are checked. The results showed that the EC scheme can eliminated the self-heating with wide grid spacing in both cases with a small reduction of the accuracies. In typical parameters, the EC implicit scheme has higher precision than EC explicit scheme. Some "numerical cooling" behaviors are observed and analyzed. Some other error are analyzed also. The analysis showed EC implicit scheme can be used to qualitative estimation of some discharge problems with much less computational resource costs without much loss of accuracies.

  10. Analysis of the excited argon atoms in the GEC RF reference cell by means of one-dimensional PIC simulations

    Energy Technology Data Exchange (ETDEWEB)

    Lauro-Taroni, L [The Open University, Oxford Research Unit, Oxford, OX1 5HR (United Kingdom); Turner, M M [Plasma Research Laboratory, School of Physical Sciences and National Centre for Plasma Science and Technology, Dublin City University, Dublin (Ireland); Braithwaite, N StJ [Open University, Oxford Research Unit, Oxford, OX1 5HR (United Kingdom)

    2004-08-21

    We examine the question of whether the excited states in argon contribute significantly to ionization in a capacitively coupled plasma through metastable pooling and step-ionization processes. We look at this issue by means of a one-dimensional particle-in-cell (PIC) code, with collisions treated by a Monte Carlo collision package. In the range explored, 50-1000 mTorr, the main source of ionization, in the absence of secondary emission, is direct ionization from the ground state with a contribution from excited states that is negligible at lower pressures, but increases in importance at higher pressures. When secondary electrons are included, their interaction with ground state neutrals dominates the ionization. At higher pressures the metastable profiles can reveal useful information on the non-uniform mean electron energy across the discharge, even though these states do not necessarily play a significant role in ionization.

  11. PIC Simulations of Continuously Driven Mirror and Ion Cyclotron Instabilities in High Beta Astrophysical and Heliospheric Plasmas

    CERN Document Server

    Riquelme, Mario; Verscharen, Daniel

    2014-01-01

    We use particle-in-cell (PIC) simulations to study the nonlinear evolution of ion velocity space instabilities in an idealized problem in which a background velocity shear continuously amplifies the magnetic field. We simulate the astrophysically relevant regime where the shear timescale is long compared to the ion cyclotron period, and the plasma beta is ~ 1-100. The background field amplification in our calculation is meant to mimic processes such as turbulent fluctuations or MHD-scale instabilities. The field amplification continuously drives a pressure anisotropy with the perpendicular pressure larger than the parallel pressure, and the plasma becomes unstable to the mirror and ion cyclotron instabilities. In all cases, the nonlinear state is dominated by the mirror instability, not the ion cyclotron instability, and the plasma pressure anisotropy saturates near the threshold for the linear mirror instability. The magnetic field fluctuations initially undergo exponential growth but saturate in a secular p...

  12. PIC simulation study of the interaction between a relativistically moving leptonic micro-cloud and ambient electrons

    CERN Document Server

    Dieckmann, M E; Markoff, S; Borghesi, M; Zepf, M

    2015-01-01

    The jets of compact accreting objects are composed of electrons and a mixture of positrons and ions. These outflows impinge on the interstellar or intergalactic medium and both plasmas interact via collisionless processes. Filamentation (beam-Weibel) instabilities give rise to the growth of strong electromagnetic fields. These fields thermalize the interpenetrating plasmas. Hitherto, the effects imposed by a spatial non-uniformity on filamentation instabilities have remained unexplored. We examine the interaction between spatially uniform background electrons and a minuscule cloud of electrons and positrons. A square micro-cloud of equally dense electrons and positrons impinges in our particle-in-cell (PIC) simulation on a spatially uniform plasma at rest. The mean speed of the micro-cloud corresponds to a relativistic factor of 15, which is relevant for laboratory experiments and for relativistic astrophysical outflows. The spatial distributions of the leptons and of the electromagnetic fields are examined a...

  13. Study on the Before Cavity Interaction in a Second Harmonic Gyrotron Using 3D CFDTD PIC Simulations

    Science.gov (United States)

    Lin, M. C.; Illy, S.; Thumm, M.; Jelonnek, J.

    2016-10-01

    A computational study on before cavity interaction (BCI) in a 28 GHz second harmonic (SH) gryotron for industrial applications has been performed using a 3-D conformal finite-difference time-domain (CFDTD) particle-in-cell (PIC) method. On the contrary to the after cavity interaction (ACI), i.e. beam wave interaction in the non-linear uptaper after the cavity, which has been widely investigated, the BCI, i.e. beam wave interaction in the non-linear downtaper before the cavity connected to the beam tunnel with an entrance, is less noticed and discussed. Usually the BCI might be considered easy to be eliminated. However, this is not always the case. As the SH gyrotron had been designed for SH TE12 mode operation, the first harmonic (FH) plays the main competition. In the 3-D CFDTD PIC simulations, a port boundary has been employed for the gyro-beam entrance of the gyrotron cavity instead of a metallic short one which is not reflecting a realistic situation as an FH backward wave oscillation (BWO) is competing with the desired SH generation. A numerical instability has been found and identified as a failure of the entrance port boundary caused by an evanescent wave or mode conversion. This indicates the entrance and downtaper are not fully cut-off for some oscillations. A further study shows that the undesired oscillation is the FH TE11 BWO mode concentrated around the beam tunnel entrance and downtaper. A mitigation strategy has been found to suppress this undesired BCI and avoid possible damage to the gun region.

  14. VizieR Online Data Catalog: A dust model for bet Pic from 0.58 to 870um (Ballering+, 2016)

    Science.gov (United States)

    Ballering, N. P.; Su, K. Y. L.; Rieke, G. H.; Gaspar, A.

    2016-08-01

    β Pic was imaged with the HST/STIS CCD in coronagraphic (50CORON) mode under program GO-12551 (PI: Apai), and the results of these observations were published in Apai et al. (2015ApJ...800..136A). The instrument bandpass is set by the response of the CCD and centered at 0.58um. We searched the HST archive and found previously unpublished observations of β Pic with the WFC3 instrument in the IR channel (filter F110W at ~1.16um) from program GO-11150 (PI: Graham). The Spitzer/MIPS observations of β Pic were taken under the Spitzer Guaranteed Time Observing Program 90 (PI: M. Werner). The data at all three bands (24, 70, and 160um) are published here for the first time. Two sets of 24um observations were obtained. The first set was obtained on 2004 March 20, the second set of data was obtained on 2004 April 11. Two sets of 70um observations were obtained. The first set was obtained on 2004 April 12. The second set was obtained on 2005 April 4. Herschel/PACS 70um scan map observations of β Pic (PI G. Olofsson, observation IDs 1342186612 and 1342186613) were published by Vandenbussche et al. (2010A&A...518L.133V). We used the ALMA 870um continuum image previously published by Dent et al. (2014Sci...343.1490D). (1 data file).

  15. Measurement and processing of gammas accompanying muon pairs in the reaction pi(-)C yields mu(+)mu(-) + gamma + X at 38 GeV

    Science.gov (United States)

    Bannikov, A. V.; Chelkov, G. A.; Krumshtejn, Z. V.; Petrukhin, V. I.; Vertogradov, L. S.; Bohm, J.; Piska, K.; Javrishvili, A. K.; Lomtadze, T. A.; Tskhadadze, E. G.

    A set of carbon targets and lead glass converters were placed in the sensitive volume of a streamer chamber of the magnetic spectrometer RISK in the experiment SERP-151 on the study of exclusive processes of production of muon pairs and J/Psi-particles in (pi)C interactions at 38 GeV.

  16. Microchip推出体积最小、成本最低的全新PIC32单片机

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Microchip美国微芯科技公司)宣布.推出全新低引脚数的32位PIC32单片机(MCU)系列,以小至5mm×5mm的封装为空间受限和成本敏感的设计提供了61DMIPS的性能。PIC32“MX1”和“MX2”MCU是体积最小、成本最低的PIC32单片机,也是第一款具有专用音频和电容式传感外设的PIC32单片机。这些新型MCU还包括众多其他有用功能,适合消费类、工业、医疗和汽车市场的各类应用。

  17. Microchip扩展低成本、小封装32位PIC32单片机系列

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Microehip Technology Ine.(美国微芯科技公司)推出全新低引脚数32位PIC32单片机(MCU)系列,以小至5mm×5mm的封装提供61 DMIPS性能,适合空间受限和成本敏感的设计。PIC32“MX1”和“MX2”MCU是体积最小且成本最低的PIC32单片机,也是第一款具有专用音频和电容式传感外设的PIC32 MCU。最新器件还配备了USB On-the-Go(OTG)功能,使其成为开发消费类、工业、医疗和汽车市场音频配件及其他应用的理想选择。

  18. Microcontroladores PIC F18: estudio y aplicación a la gestión de un aparcamiento de turismos

    OpenAIRE

    Verdejo Garrido, David

    2015-01-01

    En este trabajo de fin de grado se lleva a cabo un estudio de la familia de microcontroladores PIC F18 de Microchip. Departamento de Tecnología Electrónica Grado en Ingeniería en Electrónica Industrial y Automática

  19. New PIC/Postsecondary Partnerships: How Postsecondary Institutions and Private Industry Councils Are Working Together to Boost Economic Development and Put People Back to Work.

    Science.gov (United States)

    Fox, Shirley

    A project sought ways in which colleges and universities can work more closely with the federally funded Job Training Partnership Act to help the unemployed find work and to encourage business startups and expansion. Partnerships between postsecondary educational institutions and Private Industry Councils (PICs) at six sites were encouraged during…

  20. New PIC/Postsecondary Alliances. How Postsecondary Institutions and Private Industry Councils Are Working Together to Boost Economic Development and Put People Back to Work. Six Case Studies.

    Science.gov (United States)

    National Inst. for Work and Learning, Washington, DC.

    Case studies are provided of the six sites involved in a demonstration project to encourage partnerships between postsecondary educational institutions and Private Industry Councils (PICs). These programs represent instances of collaborations between colleges/universities and the Job Training Partnership Act to help the unemployed find work and…

  1. Functional genomic analysis of the response of Atlantic cod (Gadus morhua) spleen to the viral mimic polyriboinosinic polyribocytidylic acid (pIC).

    Science.gov (United States)

    Rise, Matthew L; Hall, Jennifer; Rise, Marlies; Hori, Tiago; Gamperl, A Kurt; Kimball, Jennifer; Hubert, Sophie; Bowman, Sharen; Johnson, Stewart C

    2008-01-01

    In order to improve our understanding of how Atlantic cod (Gadus morhua) respond to viruses, we characterized immune-related gene expression in spleen tissues following stimulation with a synthetic double-stranded RNA polyriboinosinic polyribocytidylic acid (pIC). We used reciprocal suppression subtractive hybridization (SSH) cDNA libraries and quantitative RTPCR (QPCR) to identify and quantify pIC-responsive transcripts. A total of 3874 expressed sequence tags (ESTs) were generated from SSH libraries enriched for genes responsive to pIC. Thirteen immune-relevant genes from the libraries were subjected to QPCR. Genes confirmed as up-regulated by pIC included interferon stimulated gene 15, a small inducible cytokine, interferon regulatory factors (1, 7, and 10), MHC class I, viperin, and ATP-dependent helicase LGP2. Alpha-1-microglobulin (bikunin) was down-regulated, suggesting that pIC may suppress the acute phase response. Since the SSH libraries built for this study identified genes involved in the antiviral response, they are important resources for studying the responses of Atlantic cod to viruses. Evidence is provided for the existence of a RIG-I-like RNA helicase viral recognition pathway in Atlantic cod. Taken together, our data show that Atlantic cod can recognize double-stranded RNA and mount a rapid and potent interferon pathway response that is similar to that observed in other fish species and higher vertebrates.

  2. Single-Crystal to Single-Crystal Reversible Transformations Induced by Thermal Dehydration in Keggin-Type Polyoxometalates Decorated with Copper(II-Picolinate Complexes: The Structure Directing Role of Guanidinium

    Directory of Open Access Journals (Sweden)

    Aroa Pache

    2015-05-01

    Full Text Available Three new hybrid inorganic-metalorganic compounds containing Keggin-type polyoxometalates, neutral copper(II-picolinate complexes and guanidinium cations have been synthesized in bench conditions and characterized by elemental analysis, infrared spectroscopy and single-crystal X-ray diffraction: the isostructural [C(NH23]4[{XW12O40}{Cu2(pic4}]·[Cu2(pic4(H2O]2·6H2O [X = Si (1, Ge (3] and [C(NH23]8[{SiW12O40}2{Cu(pic2}3{Cu2(pic4(H2O}2]·8H2O (2. The three compounds show a pronounced two-dimensional character owing to the structure-directing role of guanidinium. In 1 and 3, layers of [{XW12O40}{Cu2(pic4}]n4n− hybrid POM chains and layers of [Cu2(pic4(H2O] complexes and [C(NH23]+ cations pack alternately along the z axis. The hydrogen-bonding network established by guanidinium leads to a trihexagonal tiling arrangement of all copper(II-picolinate species. In contrast, layers of [C(NH23]+-linked [{SiW12O40}2{Cu(pic2}3]n8n− double chains where each Keggin cluster displays a {Cu2(pic4(H2O} moiety pointing at the intralamellar space are observed in 2. The thermal stability of 1–3 has been studied by thermogravimetric analyses and variable temperature powder X-ray diffraction. Compounds 1 and 3 undergo single-crystal to single-crystal transformations promoted by reversible dehydration processes and the structures of the corresponding anhydrous phases 1a and 3a have been established. Despite the fact that the [Cu2(pic4(H2O] dimeric complexes split into [Cu(pic2] monomers upon dehydration, the packing remains almost unaltered thanks to the preservation of the hydrogen-bonding network established by guanidinium and its associated Kagome-type lattice. Splitting of the dimeric complexes has been correlated with the electron paramagnetic resonance spectra.

  3. Re-Making the Incarceration-Nation: Naming the Participation of Schools in Our Prison Industrial Complex

    Science.gov (United States)

    Meiners, Erica R.; Reyes, Karen Benita

    2008-01-01

    In this article, the authors seek to contribute to the growing engagement with the school-prison nexus by considering two, perhaps less obvious, factors that implicate schools in the business of the prison industrial complex (PIC)--the examples of gentrification and sex offender registries. By unpacking some of the rhetoric that surrounds…

  4. Time-resolved spectroscopic analysis of the light-energy harvesting mechanism in carbazole-dendrimers with a blue-phosphorescent Ir-complex core.

    Science.gov (United States)

    Cho, Yang-Jin; Kim, So-Yoen; Son, Mi Rang; Son, Ho-Jin; Cho, Dae Won; Kang, Sang Ook

    2017-08-02

    In order to investigate the light-energy harvesting mechanism, a series of dendrimers with a heteroleptic iridium(iii) complex core, [Ir(dmb)2(pic-Czn)] (Gn: n = 1, 2, and 3), with 2,6-difluoro-3-(4-methylpyridin-2-yl)benzonitrile (dmb) as the cyclometallating ligand and 3-hydroxypicolinate (pic) as the ancillary ligand, connected to carbazole-based dendrons (Czn: n = 2, 4, and 8) was synthesized. The Ir centred complex [Ir(dmb)2(pic-OCH3), G0] shows a blue emission at SVD). The determination of the absorption spectra of the individual species participating in the energy transfer process by SVD analysis can distinguish between different mechanistic models. The analysed rate constants were consistent with the results determined by the emission decays.

  5. Implementación de un balastro electrónico con microcontrolador PIC para lámparas de sodio de alta presión; Implementation of electronic ballast with PIC microcontroller for high pressure sodiumlamps

    Directory of Open Access Journals (Sweden)

    Armando M. - Gutiérrez Menéndez

    2013-10-01

    Full Text Available En el presente trabajo se muestra un prototipo de balasto electrónico, que garantiza la operación exitosa en alta frecuencia de una lámpara de sodio de alta presión de 70 W, pues opera libre de resonancia acústica (RA. Se efectúa un análisis del fenómeno de la resonancia acústica, profundizando en su origen y predicción teórica. Es descrita la técnica de modulación en frecuencia utilizada para evitar este fenómeno, implementada en el microcontrolador de 8 bit PIC16F877 de la Microchip, la cual es activada en dependencia de la variación de los parámetros eléctricos de la lámpara, como son tensión y corriente. Son mostradas las etapas que dan conformación a dicho prototipo, además de presentarse las simulaciones realizadas a los principales elementos que componen el balasto. Los resultados prácticos alcanzados por el prototipo son expuestos, los cuales se dividen por etapas para analizar el correcto funcionamiento de cada una ellas.In the present work is offered a prototype of electronic ballast that guarantees the correctly operation in high frequency of a high pressure sodium lamp of 70 W, because it operates free of acoustic resonance (RA. An analysis of the phenomenon of the acoustic resonance is made, deepening in its origin and theoretical prediction. The modulation technique is described in frequency used to avoid this phenomenon, implemented in the microcontrolador of 8 bit PIC16F877 of Microchip, which is activated in dependence of the variation of the electric parameters of the lamp, like they are tension and current. They are shown the stages that give conformation to this prototype, besides the simulations carried out to the main elements that compose the ballast being presented. The practical results reached by the prototype are exposed, which are divided by stages to analyze the correct operation of each a them.

  6. Implementación de un balastro electrónico con microcontrolador PIC para lámparas de sodio de alta presión Implementation of electronic ballast with PIC microcontroller for high pressure sodiumlamps

    Directory of Open Access Journals (Sweden)

    Armando Manuel Gutiérrez Menéndez

    2013-09-01

    Full Text Available En el presente trabajo se muestra un prototipo de balasto electrónico, que garantiza la operación exitosa en alta frecuencia de una lámpara de sodio de alta presión de 70 W, pues opera libre de resonancia acústica (RA. Se efectúa un análisis del fenómeno de la resonancia acústica, profundizando en su origen y predicción teórica. Es descrita la técnica de modulación en frecuencia utilizada para evitar este fenómeno, implementada en el microcontrolador de 8 bit PIC16F877 de la Microchip, la cual es activada en dependencia de la variación de los parámetros eléctricos de la lámpara, como son tensión y corriente. Son mostradas las etapas que dan conformación a dicho prototipo, además de presentarse las simulaciones realizadas a los principales elementos que componen el balasto. Los resultados prácticos alcanzados por el prototipo son expuestos, los cuales se dividen por etapas para analizar el correcto funcionamiento de cada una ellas.Palabra clave: In the present work is offered a prototype of electronic ballast that guarantees the correctly operation in high frequency of a high pressure sodium lamp of 70 W, because it operates free of acoustic resonance (RA. An analysis of the phenomenon of the acoustic resonance is made, deepening in its origin and theoretical prediction. The modulation technique is described in frequency used to avoid this phenomenon, implemented in the microcontrolador of 8 bit PIC16F877 of Microchip, which is activated in dependence of the variation of the electric parameters of the lamp, like they are tension and current. They are shown the stages that give conformation to this prototype, besides the simulations carried out to the main elements that compose the ballast being presented. The practical results reached by the prototype are exposed, which are divided by stages to analyze the correct operation of each a them.Key words:

  7. Preparation and Single-Crystal X-Ray Structures of Four Related Mixed-Ligand 4-Methylpyridine Indium Halide Complexes

    Science.gov (United States)

    Hepp, Aloysius F.; Clark, Eric B.; Schupp, John D.; Williams, Jennifer N.; Duraj, Stan A.; Fanwick, Philip E.

    2013-01-01

    We describe the structures of four related indium complexes obtained during synthesis of solid-state materials precursors. Indium adducts of halides and 4-methylpyridine, InX3(pic)3 (X = Cl, Br; pic = 4-methylpyridine) consist of octahedral molecules with meridional (mer) geometry. Crystals of mer-InCl3(pic)3 (1) are triclinic, space group P1(bar) (No. 2), with a = 9.3240(3), b = 13.9580(6), c = 16.7268 (7) A, alpha = 84.323(2), beta = 80.938(2), gamma = 78.274(3)Z = 4, R = 0.035 for 8820 unique reflections. Crystals of mer-InBr3(pic)3 (2) are monoclinic, space group P21/n (No. 14), with a = 15.010(2), b = 19.938(2), c = 16.593(3), beta = 116.44(1)Z = 8, R = 0.053 for 4174 unique reflections. The synthesis and structures of related compounds with phenylsulfide (chloride) (3) and a dimeric complex with bridging hydroxide (bromide) (4) coordination is also described. Crystals of trans-In(SC6H5)Cl2(pic)3 (3) are monoclinic, space group P21/n (No. 14), with a = 9.5265(2), b = 17.8729(6), c = 13.8296(4), beta = 99.7640(15)Z = 4, R = 0.048 for 5511 unique reflections. Crystals of [In(mu-OH)Br2(pic)22 (4) are tetragonal, space group = I41cd (No. 110) with a = 19.8560(4), b = 19.8560(4), c = 25.9528(6), Z = 8, R = 0.039 for 5982 unique reflections.

  8. Using PIC 16C 54 chip microcomputer to realize the design of the stepping motor controllers for DF4 locomotives%用PIC16C54单片机设计DF4型机车步进电机驱动器

    Institute of Scientific and Technical Information of China (English)

    许连忠

    2003-01-01

    介绍使用PIC16C54单片机设计DF4型机车步进电机驱动器的方法,给出了硬件电路和应用软件.用PIC16C54单片机设计的东风4型机车步进电机驱动器的硬件电路比现在使用的普通步进电机驱动器的硬件电器结构大为简化,易于故障查找和维护.

  9. Peptide sequences identified by phage display are immunodominant functional motifs of Pet and Pic serine proteases secreted by Escherichia coli and Shigella flexneri.

    Science.gov (United States)

    Ulises, Hernández-Chiñas; Tatiana, Gazarian; Karlen, Gazarian; Guillermo, Mendoza-Hernández; Juan, Xicohtencatl-Cortes; Carlos, Eslava

    2009-12-01

    Plasmid-encoded toxin (Pet) and protein involved in colonization (Pic), are serine protease autotransporters of Enterobacteriaceae (SPATEs) secreted by enteroaggregative Escherichia coli (EAEC), which display the GDSGSG sequence or the serine motif. Our research was directed to localize functional sites in both proteins using the phage display method. From a 12mer linear and a 7mer cysteine-constrained (C7C) libraries displayed on the M13 phage pIII protein we selected different mimotopes using IgG purified from sera of children naturally infected with EAEC producing Pet and Pic proteins, and anti-Pet and anti-Pic IgG purified from rabbits immunized with each one of these proteins. Children IgG selected a homologous group of sequences forming the consensus sequence, motif, PQPxK, and the motifs PGxI/LN and CxPDDSSxC were selected by the rabbit anti-Pet and anti-Pic IgGs, respectively. Analysis of the amino terminal region of a panel of SPATEs showed the presence in all of them of sequences matching the PGxI/LN or CxPDDSSxC motifs, and in a three-dimensional model (Modeller 9v2) designed for Pet, both these motifs were found in the globular portion of the protein, close to the protease active site GDSGSG. Antibodies induced in mice by mimotopes carrying the three aforementioned motifs were reactive with Pet, Pic, and with synthetic peptides carrying the immunogenic mimotope sequences TYPGYINHSKA and LLPQPPKLLLP, thus confirming that the peptide moiety of the selected phages induced the antibodies specific for the toxins. The antibodies induced in mice to the PGxI/LN and CxPDDSSxC mimotopes inhibited fodrin proteolysis and macrophage chemotaxis biological activities of Pet. Our results showed that we were able to generate, by a phage display procedure, mimotopes with sequence motifs PGxI/LN and CxPDDSSxC, and to identify them as functional motifs of the Pet, Pic and other SPATEs involved in their biological activities.

  10. 基于PIC18F45J10的TEC半导体工业空调控制系统%TEC Peltier Industry Air Conditioner Control System based on PIC18F45J10

    Institute of Scientific and Technical Information of China (English)

    李睿; 芮贤义

    2011-01-01

    This paper introduces the structure and advantage of TEC peltier industry air conditioner system at first, and its design by bilolar control based on PICI8F45510, describes its functions and features. Then research its working principle design its input main circuit, output load circuit etc. The experiment results indicate that TEC peltier industry air conditioner control system with low cost, high efficiency is feasible.%本文首先介绍了TEC半导体工业空调控制系统的结构和优点,设计了基于PIC18F45J10的双极性控制器构成的TEC半导体工业空调,阐述了其功能和特点.接着研究TEC半导体工业空调控制系统的工作原理,设计输入主电路,输出负载控制电路等.实验结果表明低成本,高效率的TEC半导体工业空调控制系统的可行性.

  11. 基于PIC16F84的电磁阀式IC卡水表设计研究%Design of IC Card Water Meter Based on PIC16F84 Microcontroller Chips

    Institute of Scientific and Technical Information of China (English)

    冯静

    2008-01-01

    利用现代化智能技术对自来水供应实行自动监控,不仅是适应国家用水制度的改革的需要,而且是解决供水部门抄表收费过程中所存在系列问题的内在要求.研究开发的电磁阀式IC卡水表能够满足上述功能要求.其硬件电路的核心部件是PIC16F84可编程单片机芯片,并配置有阀门、流量传感器、IC卡读/写器等外部元件.软件设计上实现了控制、显示及报警等功能,芯片具有数据可擦写次数多、数据保持时间长等优点.应用该产品可以把即时用水即时付费变成现实,改变了先用水后收费的不合理现状,有利于公用事业的发展.

  12. Design of Bulk Data Transmission Module Based on PIC18F4550%基于PIC18F4550的批量数传模块的设计

    Institute of Scientific and Technical Information of China (English)

    安国娇; 王代华; 张志杰

    2010-01-01

    USB总线是一种新型的计算机总线接口标准,而USB2.0的高速特点又是其他总线标准所无法替代的.文中针对外设与PC机的批量数据传输需求,设计了一个基于PIC18F4550的批量数据传输模块.详细阐述了软硬件设计方案,包括硬件电路设计、固件程序、驱动程序以及应用程序编写.实验证明,该模块的通信速率高达8Mb/s,满足全速USB2.0的要求.该设计具有电路简单、便于集成等特点,已成功应用于某存储测试系统中.

  13. Programming Method of an Avoidance Overflowing Based on PIC16 Series Single Chip%一种基于PIC16系列单片机的防程序飞溢编程方法

    Institute of Scientific and Technical Information of China (English)

    张光; 李学仁

    2005-01-01

    PIC16系列单片机如何安全使用查表指令避免出现程序飞溢现象是编程的难点之一.本文针对此现象进行了研究,分析了产生程序飞溢的几种原因;归纳了应用中经常遇到的几种表现;结合实例给出了一种安全实用的解决方案,并采用流程图和编程相结合的方式与PCLATH的0~3位预置判别法进行了比较.本方法指令语句简单、可靠性高、易于操作,对初学者和其他技术人员有很大的帮助.经在CDJ-01充电站环境自动监控系统应用,证明具有一定的实用价值.

  14. Interactions between Bioactive Diperoxovanadate Complexes and Imidazole:Insights into Their Solution Structures by NMR and ESI-MS

    Institute of Scientific and Technical Information of China (English)

    于贤勇; 蔡淑惠; 陈忠

    2004-01-01

    The interactions between four high bioactive diperoxovanadate complexesKn[OV(O2)2L]·mH2O (n = 1 ~3, m = 1~5, L = oxalate (abbr. oxa), picolinate (abbr. pic), bipyridine (abbr. bipy) and 1,10-phenanthroline (abbr. phen); their corresponding complexes abbreviated as bpV(oxa), bpV(pic), bpV(bipy) and bpV(phen), respectively) and imidazole (abbr. imi) in solution were studied by several NMR techniques: multinuclear (1H, 13C and 51V) and variable temperature 51V NMR. Competitive coordination interactions were observed and the order of the interaction strength of the four complexes with imidazole is as follows: bpV(oxa) > bpV(pic) > bpV(bipy) >bpV(phen), which is deeply affected by the identity of the ligands and has the same order as their inhibition effect toward bovine heart phosphotyrosyl protein phosphatase. The species [OV(O2)2(imi)]- was formedin all cases. Both of the NMR data and equilibrium constants of the interaction systems were reported. The experimental results indicate that the species of bpV(oxa)and [OV(O2)2(imi)]- are six-coordinated, while bpV(pic), bpV(bipy) and bpV(phen) are sevencoordinated in solution. ESI-MS results support the conclusions obtained by NMR.

  15. Mariano Picón Salas y la búsqueda de los ideales: la reivindicación de lo humano

    Directory of Open Access Journals (Sweden)

    Jhoerson Yagmour

    2013-07-01

    Full Text Available The present paper studies the vindication of what is human in the thought of Mariano Picón Salas (1901-1965, particularly regarding the author’s ideas in the texts Regreso de tres mundos, Literatura y sociedad, Cultura y soseigo and Vicisitudes en el arte de historiar. In these texts, the search for Picón Salas’ ideals works as a transversal reading which reveals two central ideas according to which the author favours: 1 an aesthetics of the work of art, based on the picture of human condition that only be offered by literature, and 2 the construction of an ethics of reading, a form of interpretation that allows us to see the humane dimension in man’s greatest searches.

  16. An interface board for developing control loops in power electronics based on microcontrollers and DSPs Cores -Arduino /ChipKit /dsPIC /DSP /TI Piccolo

    DEFF Research Database (Denmark)

    Pittini, Riccardo; Zhang, Zhe; Andersen, Michael A. E.

    2013-01-01

    and development environment. Moreover, the interface board can operate with open hardware Arduino-like boards such as the ChipKit Uno32. The paper also describes how to enhance the performance of a ChipKit Uno32 with a dsPIC obtaining a more suitable solution for power electronics. The basic blocks and interfaces...... of the boards are presented in detail as well as the board main specifications. The board operation has been tested with three core platforms: TI Piccolo controlSTICK, a Microchip dsPIC and a ChipKit Uno32 (Arduino-like platform). The board was used for generating test signals for characterizing 1200 V Si...

  17. 学生机长训练中的驾驶舱资源管理%Cockpit Resource Management in the Training of PIC

    Institute of Scientific and Technical Information of China (English)

    耿栓柱

    2012-01-01

    本文研究了学生机长训练阶段中如何配置人力资源、营运信息、设备资源和易耗资源,对提高学生机长的驾驶舱资源管理水平提出建议,以最优化资源效用,大幅提升训练安全和质量。%The management of human resources,operation resources,equipment resources and consumable resources in the training of PIC were analyzed.The article makes suggestions on how to improve cockpit resource management of PIC,in order to optimize the resource utility,and enhance the training safety and quality.

  18. 基于PIC单片机的直流无刷电机驱动控制器%Brushless DC Motor Controller Based on PIC MCU

    Institute of Scientific and Technical Information of China (English)

    吕仲军; 刘泽潮

    2014-01-01

    介绍了一种基于PIC18Fxx单片机的直流无刷电机的控制器;实现了电机的过流保护、欠压保护、PWM调速和速度闭环控制;设计了主要的硬件电路;并给出了部分软件流程图。通过实验与仿真验证了系统的可靠性与稳定性。%This paper introduces a brushless DC motor controller based on the PIC 18Fxx MCU.The Motor Hall signal acquisition , overcurrent protection , undervoltage protection , PWM speed control and speed closed-loop control are realized .The main hardware circuit and the flowchart of software are designed .The reliability and stability of the system is verified by experiment and simulation .

  19. Redescriptions of Scirtidae (Coleoptera: Scirtoidea) described by Carl Henrik Boheman (1796-1868) with notes on Scirtes adustus iversenotatus Pic, 1930.

    Science.gov (United States)

    Ruta, Rafał; Libonatti, María Laura

    2016-01-29

    Boheman described four species of Scirtidae: one from Sweden (Cyphon pallidulus Boheman, 1850), two from South Africa (Elodes caffer Boheman, 1851 & Elodes marginipennis Boheman, 1851), and one from Argentina (Scirtes adustus Boheman, 1858). Cyphon pallidulus Boheman is a junior synonym of Contacyphon ochraceus (Stephens, 1830). Types of the remaining species were never re-examined, and none of them were redescribed. In the present paper, three species are redescribed on the basis of type specimens deposited in the Swedish Natural History Museum in Stockholm. Genitalia are illustrated for the first time and a new combination is proposed: Brachycyphon marginipennis (Boheman, 1851). The type specimen of a variety described by Pic, S. adustus var. diversenotatus, was examined and revealed to represent a distinct species, which is redescribed under the name of Scirtes diversenotatus Pic, 1930 stat. nov. in the present paper.

  20. The influence of DHEA pretreatment on prepulse inhibition and the HPA-axis stress response in rat offspring exposed prenatally to polyriboinosinic-polyribocytidylic-acid (PIC).

    Science.gov (United States)

    Maayan, Rachel; Ram, Edward; Biton, Doron; Cohen, Hagit; Baharav, Ehud; Strous, Rael D; Weizman, Abraham

    2012-07-11

    Prenatal exposure to maternal infection may be associated with the development of neurodevelopmental disorders as well as increased susceptibility to the development of schizophrenia. Prenatal administration of polyriboinosinic-polyribocytidilic-acid, mimicking RNA virus exposure, has been shown to induce schizophrenia-like behavioral, neurochemical and neuorophysiological abnormalities in rodent offspring. In the present study PIC prenatal administration at gestation day 15 was associated with alterations in the acoustic-startle-response/prepulse-inhibition [ASR/PPI] and the HPA-axis stress response in rat offspring on day 90. We show that pretreatment with dehydroepiandrosterone (DHEA) reverses PIC-related ASR/PPI disruption in female rats and normalizes HPA-axis stress response in a united group of male and female rats. Further research in both animal and human studies is recommended in order to confirm these preliminary findings and their application to the understanding and management of schizophrenia and related conditions.

  1. 3D PIC-MCC simulations of discharge inception around a sharp anode in nitrogen/oxygen mixtures

    Science.gov (United States)

    Teunissen, Jannis; Ebert, Ute

    2016-08-01

    We investigate how photoionization, electron avalanches and space charge affect the inception of nanosecond pulsed discharges. Simulations are performed with a 3D PIC-MCC (particle-in-cell, Monte Carlo collision) model with adaptive mesh refinement for the field solver. This model, whose source code is available online, is described in the first part of the paper. Then we present simulation results in a needle-to-plane geometry, using different nitrogen/oxygen mixtures at atmospheric pressure. In these mixtures non-local photoionization is important for the discharge growth. The typical length scale for this process depends on the oxygen concentration. With 0.2% oxygen the discharges grow quite irregularly, due to the limited supply of free electrons around them. With 2% or more oxygen the development is much smoother. An almost spherical ionized region can form around the electrode tip, which increases in size with the electrode voltage. Eventually this inception cloud destabilizes into streamer channels. In our simulations, discharge velocities are almost independent of the oxygen concentration. We discuss the physical mechanisms behind these phenomena and compare our simulations with experimental observations.

  2. L’anàlisi de conglomerats bietàpic o en dues fases amb SPSS

    Directory of Open Access Journals (Sweden)

    Maria-José Rubio-Hurtado

    2017-01-01

    Full Text Available El procediment d'anàlisi de conglomerats en dues fases, també anomenat bietàpic, és una eina d'exploració dissenyada per descobrir les agrupacions naturals d'un conjunt de dades. Permet la generació de criteris d'informació, freqüències dels conglomerats i estadístics descriptius per conglomerat, així com gràfics de barres, sectors i gràfics d'importància de les variables. El mètode d'anàlisi de conglomerats en dues fases té unes funcions úniques respecte a altres mètodes de conglomeració tradicionals, com són: un procediment automàtic del nombre òptim de conglomerats, la possibilitat de crear models de conglomerats amb variables tant categòriques com contínues, o la possibilitat de treballar amb arxius de dades de grans dimensions.

  3. Control device for automatic orientation of a solar panel based on a microcontroller (PIC16f628a)

    Science.gov (United States)

    Rezoug, M. R.; Krama, A.

    2016-07-01

    This work proposes a control device for autonomous solar tracker based on one axis, It consists of two main parts; the control part which is based on "the PIC16f628a"; it has the role of controlling, measuring and plotting responses. The second part is a mechanical device, which has the role of making the solar panel follows the day-night change of the sun throughout the year. Both parties are established to improve energy generation of the photovoltaic panels. In this paper, we will explain the main operating principles of our system. Also, we will provide experimental results which demonstrate the good performance and the efficiency of this system. This innovation is different from what has been proposed in previous studies. The important points of this system are maximum output energy and minimum energy consumption of solar tracker, its cost is relatively low with simplicity in implementation. The average power increase produced by using the tracking system for a particular day, is over 30 % compared with the static panel.

  4. Modeling of Laser wakefield acceleration in Lorentz boosted frame using EM-PIC code with spectral solver

    CERN Document Server

    Yu, Peicheng; Decyk, Viktor K; An, Weiming; Vieira, Jorge; Tsung, Frank S; Fonseca, Ricardo A; Lu, Wei; Silva, Luis O; Mori, Warren B

    2013-01-01

    Simulating laser wakefield acceleration (LWFA) in a Lorentz boosted frame in which the plasma drifts towards the laser with $v_b$ can speedup the simulation by factors of $\\gamma^2_b=(1-v^2_b/c^2)^{-1}$. In these simulations the relativistic drifting plasma inevitably induces a high frequency numerical instability that contaminates the interested physics. Various approaches have been proposed to mitigate this instability. One approach is to solve Maxwell equations in Fourier space (a spectral solver) as this has been shown to suppress the fastest growing modes of this instability in simple test problems using a simple low pass, ring (in two dimensions), or shell (in three dimensions) filter in Fourier space. We describe the development of a fully parallelized, multi-dimensional, particle-in-cell code that uses a spectral solver to solve Maxwell's equations and that includes the ability to launch a laser using a moving antenna. This new EM-PIC code is called UPIC-EMMA and it is based on the components of the U...

  5. Creating a transducer electronic datasheet using I2C serial EEPROM memory and PIC32-based microcontroller development board

    Science.gov (United States)

    Croitoru, Bogdan; Tulbure, Adrian; Abrudean, Mihail; Secara, Mihai

    2015-02-01

    The present paper describes a software method for creating / managing one type of Transducer Electronic Datasheet (TEDS) according to IEEE 1451.4 standard in order to develop a prototype of smart multi-sensor platform (with up to ten different analog sensors simultaneously connected) with Plug and Play capabilities over ETHERNET and Wi-Fi. In the experiments were used: one analog temperature sensor, one analog light sensor, one PIC32-based microcontroller development board with analog and digital I/O ports and other computing resources, one 24LC256 I2C (Inter Integrated Circuit standard) serial Electrically Erasable Programmable Read Only Memory (EEPROM) memory with 32KB available space and 3 bytes internal buffer for page writes (1 byte for data and 2 bytes for address). It was developed a prototype algorithm for writing and reading TEDS information to / from I2C EEPROM memories using the standard C language (up to ten different TEDS blocks coexisting in the same EEPROM device at once). The algorithm is able to write and read one type of TEDS: transducer information with standard TEDS content. A second software application, written in VB.NET platform, was developed in order to access the EEPROM sensor information from a computer through a serial interface (USB).

  6. Isotopic Composition of Gaseous Elemental Mercury in the Free Troposphere of the Pic du Midi Observatory, France.

    Science.gov (United States)

    Fu, Xuewu; Marusczak, Nicolas; Wang, Xun; Gheusi, François; Sonke, Jeroen E

    2016-06-07

    Understanding the sources and transformations of mercury (Hg) in the free troposphere is a critical aspect of global Hg research. Here we present one year of observations of atmospheric Hg speciation and gaseous elemental Hg (GEM) isotopic composition at the high-altitude Pic du Midi Observatory (2860 m above sea level) in France. Biweekly integrated GEM from February 2012 to January 2013 revealed significant variations in δ(202)HgGEM (-0.04‰ to 0.52‰) but not in Δ(199)HgGEM (-0.17‰ to -0.27‰) or Δ(200)HgGEM (-0.10‰ to 0.05‰). δ(202)HgGEM was negatively correlated with CO and reflected air mass origins from Europe (high CO, low δ(202)HgGEM) and from the Atlantic Ocean (low CO, high δ(202)HgGEM). We suggest that the δ(202)HgGEM variations represent mixing of recent low δ(202)HgGEM European anthropogenic emissions with high δ(202)HgGEM northern hemispheric background GEM. In addition, Atlantic Ocean free troposphere air masses showed a positive correlation between δ(202)HgGEM and gaseous oxidized Hg (GOM) concentrations, indicative of mass-dependent Hg isotope fractionation during GEM oxidation. On the basis of atmospheric δ(202)HgGEM and speciated Hg observations, we suggest that the oceanic free troposphere is a reservoir within which GEM is readily oxidized to GOM.

  7. Kinetic Simulations - Oshun (Vlasov-Fokker-Planck) and PIC (Osiris) - Physics and Open Source Software In The UCLA PICKSE Initiative

    Science.gov (United States)

    Tableman, Adam; Tzoufras, Michail; Fonseca, Ricardo; Mori, W. B.

    2016-10-01

    We present physics results and general updates for two plasma kinetic simulation codes developed under the UCLA PICKSE initiative. We also discuss the issues around making these codes open source such that they can be used (and contributed too) by a large audience. The first code discussed is Oshun - a Vlasov-Fokker-Planck (VFP) code. Recent simulations with the VFP code OSHUN will be presented for all of the aforementioned problems. The algorithmic improvements that have facilitated these studies will be also be discussed. The second code discussed is the PIC code Osiris. Osiris is a widely respected code used in hundreds of papers. Osiris was first developed for laser-plasma interactions but has grown into a robust framework covering most areas of plasma research. One defining feature of Osiris is that it is highly optimized for a variety of hardware configurations and scales linearly over 1 million + CPU nodes. We will discuss the recently released version 4.0 written in modern, fully-object oriented FORTRAN. Funding provided by Grants NSF ACI 1339893 and DOE DE NA 0001833.

  8. Microchip推出首批具备增强型中档8位内核的PIC(R)单片机系列

    Institute of Scientific and Technical Information of China (English)

    Microchip公司

    2009-01-01

    @@ 全球领先的单片机和模拟半导体供应商Microchip Technology Inc.(美国微芯科技公司)近日宣布,面向中国市场推出采用Microchip增强型中档8位内核的首批6款PIC16F193X系列单片机(MCU).

  9. Microchip推出6引脚单片机PIC10F期以小兵立大功

    Institute of Scientific and Technical Information of China (English)

    黄秀玲

    2004-01-01

    继先前宣布在全球8位单片机销量夺冠后,Microchip公司日前又展开新动作。新款6引脚8位单片机产品PIC10F的问世,使得Microchip公司能突破现有应用范畴、拓展单片机的应用领域。

  10. Immunological responses of turbot (Psetta maxima) to nodavirus infection or polyriboinosinic polyribocytidylic acid (pIC) stimulation, using expressed sequence tags (ESTs) analysis and cDNA microarrays.

    Science.gov (United States)

    Park, Kyoung C; Osborne, Jane A; Montes, Ariana; Dios, Sonia; Nerland, Audun H; Novoa, Beatriz; Figueras, Antonio; Brown, Laura L; Johnson, Stewart C

    2009-01-01

    To investigate the immunological responses of turbot to nodavirus infection or pIC stimulation, we constructed cDNA libraries from liver, kidney and gill tissues of nodavirus-infected fish and examined the differential gene expression within turbot kidney in response to nodavirus infection or pIC stimulation using a turbot cDNA microarray. Turbot were experimentally infected with nodavirus and samples of each tissue were collected at selected time points post-infection. Using equal amount of total RNA at each sampling time, we made three tissue-specific cDNA libraries. After sequencing 3230 clones we obtained 3173 (98.2%) high quality sequences from our liver, kidney and gill libraries. Of these 2568 (80.9%) were identified as known genes and 605 (19.1%) as unknown genes. A total of 768 unique genes were identified. The two largest groups resulting from the classification of ESTs according to function were the cell/organism defense genes (71 uni-genes) and apoptosis-related process (23 uni-genes). Using these clones, a 1920 element cDNA microarray was constructed and used to investigate the differential gene expression within turbot in response to experimental nodavirus infection or pIC stimulation. Kidney tissue was collected at selected times post-infection (HPI) or stimulation (HPS), and total RNA was isolated for microarray analysis. Of the 1920 genes studied on the microarray, we identified a total of 121 differentially expressed genes in the kidney: 94 genes from nodavirus-infected animals and 79 genes from those stimulated with pIC. Within the nodavirus-infected fish we observed the highest number of differentially expressed genes at 24 HPI. Our results indicate that certain genes in turbot have important roles in immune responses to nodavirus infection and dsRNA stimulation.

  11. CAN Bus Extension Technique Based on PIC Single Chip Computer%基于PIC单片机的CAN总线扩展技术

    Institute of Scientific and Technical Information of China (English)

    刘广敏; 欧阳红晋; 成巍

    2009-01-01

    目前现场CAN总线驱动节点数量有限,通信速率随着通信距离的增加快速下降,在通信节点数量大、通信距离远的大空间场所不能应用.针对这个问题,设计了基于PIC16位单片机dsPIC30F6011的CAN网关,给出了CAN网关的硬件设计原理和软件设计框图;详细描述了CAN总线扩展原理及CAN总线扩展后的网络拓扑结构.dsPIC30F6011片上集成了双CAN总线数据链路层,外围电路简单,消息通过中断来处理,实时迅速.通过该CAN网关,两个CAN网络之间的消息实时、快速转发.扩展后的CAN网络驱动能力强、通信速率高、通信距离远,完全可以应用于通信节点数量大、通信距离远的场所.

  12. Induction of cell self-organization on weakly positively charged surfaces prepared by the deposition of polyion complex nanoparticles of thermoresponsive, zwitterionic copolymers.

    Science.gov (United States)

    Iwai, Ryosuke; Haruki, Ryota; Nemoto, Yasushi; Nakayama, Yasuhide

    2017-07-01

    We have developed inducible cell self-organization through weakly positively charged culture surfaces. In this study, a thermoresponsive and zwitterionic copolymer comprised of N,N-dimethylaminoethyl methacrylate (DMAEMA) and methacrylic acid (MA) (PDMAEMA-co-PMA; Mn: ∼9.7 × 10(4) g/mol; PDMAEMA/PMA ratio: 10) was designed for inducing cell self-organization. The copolymer formed single polymer-derived polyion complex (sPIC) nanoparticles following dissolution in an aqueous solution. The sPIC nanoparticles had a positive charge (ca. 25 mV). Self-organization occurred in adipose-derived vascular stromal cell monolayers cultivated on sPIC-deposited surfaces. There were dramatic morphological changes of these cells with the formation of capillary-like networks and single-cell aggregates with little cytotoxicity. This was a significant improvement compared with cells grown on previously developed surfaces deposited with PIC, a mixture of PDMAEMA and plasmid DNA. Thus, sPICs of PDMAEMA-co-PMA may allow for the accurate evaluation of a variety of cell behaviors with less cytotoxicity, and may facilitate additional potential medical applications such as cell-based therapy and drug discovery. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1009-1015, 2017. © 2016 Wiley Periodicals, Inc.

  13. Cinnamaldehyde Derivative (CB-PIC Sensitizes Chemo-Resistant Cancer Cells to Drug-Induced Apoptosis via Suppression of MDR1 and its Upstream STAT3 and AKT Signalling

    Directory of Open Access Journals (Sweden)

    Jianzhong Xi

    2015-03-01

    Full Text Available Background/Aims: Our group reported that cinnamaldehyde derivative, (E-4-((2-(3-oxopop-1-enylphenoxymethylpyridinium malonic acid (CB-PIC induced apoptosis in hypoxic SW620 colorectal cancer cells via activation of AMP-activated protein kinase (AMPK and extracellular signal regulated kinase (ERK. Herein, sensitizing effect of CB-PIC was investigated in resistant cancer cells such as paclitaxel (PT resistant lung cancer cells (H460/PT, and Adriamycin (Adr resistant breast cancer (MCF7/Adr and colon cancer (HCT15/cos cells. Methods: Various drug resistant cell lines were treated with CB-PIC, and the signalling pathway and functional assay were explored by Western blot, Rhodamine assay, FACS, RT-PCR and MTT assay. Results: We found that CB-PIC effectively exerted cytotoxicity, increased sub G1 population and the cleaved form of poly (ADP-ribose polymerase (PARP and caspase 9 in drug resistant cancer cells. Furthermore, CB-PIC sensitized resistant cancer cells to adriamycin via downregulation of survival proteins such as survivin, Bcl-xL and Bcl-2, along with MDR1 suppression leading to accumulation of drug in the intracellular region. Of note, CB-PIC transcriptionally decreased MDR1 expression via suppression of STAT3 and AKT signalling in three resistant cancer cells with highly expressed P-glycoprotein. Nonetheless, CB-PIC did not affect transport activity of P-glycoprotein in a short time efflux assay, while epigallocatechin gallate (EGCG accumulated Rhodamine 123 into intracellular region of cell by direct inhibition of MDR1 transport activity. Conclusions: These data demonstrate that CB-PIC suppresses the P-glycoprotein expression through inhibition of STAT3 and AKT signalling to overcome drug resistance in chemo-resistant cancer cells as a potent chemotherapeutic sensitizer.

  14. Mechanism of Arc Discharge in Vacuum Interrupter Based on PIC-MCC Method

    Institute of Scientific and Technical Information of China (English)

    CAO Yun-dong; LI Jing; LIU Xiao-ming; HOU Chun-guang; WANG Er-zhi

    2011-01-01

    With the raise of voltage level in electric power grid, the phenomena of high voltage gas insulation has re- ceived extensive attention from all over the world. The research on the breakdown mechanism of vacuum which is the main insulation gas in high voltage level is one of the most important issues. It is also important to the study of vacu- um arc in vacuum switch. But for the limitations of available method used in analyzing the breakdown mechanism of vacuum, the main research on vacuum breakdown is macroscopic experiment. The experiments are greatly influenced by environmental factors and high vacuum degree is difficult to be ensured. So the data from the experiments are dis- persive and the complex physical change in vacuum breakdown can not be revealed. The purpose of this work is to an- alyze the mechanism of vacuum breakdown quantitatively by microscopic numerical simulation. The particle in cell and Monte Carlo methods are used here to solve microscopic dynamic equation of gas. Based on the field emission theory in vacuum, electrons produced by the cathode and ions produced by the collision between electron and metal vapor molecule are the objects of this study. The motions of microscopic particles which are at the functions of the applied and self-consistent electric filed are traced in time and two space dimensions. Mont Carlo method is used here to cope with the collisions between electrons and metal vapor molecules. The cross sections of the collision which is related with the energy are all from the experiments. The secondary electron emission, exciting, elastic and ionizing collisions between electrons and metal vapor molecules have been considered in this paper. By the simulation, the number densi- ties of electron and ion are acquired and the microscopic dynamic electric field produced by space charge is also calcu- lated. The effect of vacuum degree on discharge voltage is also discussed here. According to the simulation data, we draw the

  15. Target-stimulated metallic HgS nanostructures on a DNA-based polyion complex membrane for highly efficient impedimetric detection of dissolved hydrogen sulfide.

    Science.gov (United States)

    Zhuang, Junyang; Fu, Libing; Lai, Wenqiang; Tang, Dianping; Chen, Guonan

    2013-12-11

    Target-stimulated metallic HgS nanostructures formed on the DNA-based polyion complex (PIC) membrane were for the first time utilized as an efficient scheme for impedimetric detection of hydrogen sulfide (H2S) by coupling insoluble precipitation with sensitivity enhancement.

  16. The effects of different solvents and excitation wavelength on the photophysical properties of two novel Ir(III) complexes based on phenylcinnoline ligand.

    Science.gov (United States)

    Xu, Jing; Yang, Chaolong; Tong, Bihai; Zhang, Yunfei; Liang, Liyan; Lu, Mangeng

    2013-09-01

    Two novel cyclometalated iridium(III) complexes, Ir(pcl)2(pic) and Ir(pcl)2(fpic) (pcl: 3-phenylcinnoline, pic: picolinic acid, fpic: 5-fluoro-2-picolinic acid) were synthesized and characterized by FTIR, (1)H NMR spectroscopy, UV-vis, PL, and MALDI-TOF. These two Ir-complexes geometry were predicted using the Sparkle/PM6 model and suggested to a chemical environment of very low symmetry around the Ir ions (C 1). The PL spectrum of Ir(pcl)2(pic) and Ir(pcl)2(fpic) indicated that these complex belonged to red light emission, and maximum emission wavelength located at 647 and 641 nm, respectively. Most importantly, the effects of different solvents on their photoluminescent properties were detailed investigated. The results indicated that the polarity of solvent played an important role for their emission spectra. With introducing fluoro group to the pyridyl ring, the maximum emission wavelength of Ir(pcl)2(fpic) was blue shifted about 6 nm, and the quantum yield was slightly higher than that of Ir(pcl)2(pic). In addition, the thermal properties of these two Ir-complexes were measured by TGA, and results indicated that they had relative good thermal properties.

  17. Development and Benchmarking of a Hybrid PIC Code For Dense Plasmas and Fast Ignition

    Energy Technology Data Exchange (ETDEWEB)

    Witherspoon, F. Douglas [HyperV Technologies Corp.; Welch, Dale R. [Voss Scientific, LLC; Thompson, John R. [FAR-TECH, Inc.; MacFarlane, Joeseph J. [Prism Computational Sciences Inc.; Phillips, Michael W. [Advanced Energy Systems, Inc.; Bruner, Nicki [Voss Scientific, LLC; Mostrom, Chris [Voss Scientific, LLC; Thoma, Carsten [Voss Scientific, LLC; Clark, R. E. [Voss Scientific, LLC; Bogatu, Nick [FAR-TECH, Inc.; Kim, Jin-Soo [FAR-TECH, Inc.; Galkin, Sergei [FAR-TECH, Inc.; Golovkin, Igor E. [Prism Computational Sciences, Inc.; Woodruff, P. R. [Prism Computational Sciences, Inc.; Wu, Linchun [HyperV Technologies Corp.; Messer, Sarah J. [HyperV Technologies Corp.

    2014-05-20

    Computational Sciences, Inc. and Advanced Energy Systems Inc. joined efforts to develop new physics and numerical models for LSP in several key areas to enhance the ability of LSP to model high energy density plasmas (HEDP). This final report details those efforts. Areas addressed in this research effort include: adding radiation transport to LSP, first in 2D and then fully 3D, extending the EMHD model to 3D, implementing more advanced radiation and electrode plasma boundary conditions, and installing more efficient implicit numerical algorithms to speed complex 2-D and 3-D computations. The new capabilities allow modeling of the dominant processes in high energy density plasmas, and further assist the development and optimization of plasma jet accelerators, with particular attention to MHD instabilities and plasma/wall interaction (based on physical models for ion drag friction and ablation/erosion of the electrodes). In the first funding cycle we implemented a solver for the radiation diffusion equation. To solve this equation in 2-D, we used finite-differencing and applied the parallelized sparse-matrix solvers in the PETSc library (Argonne National Laboratory) to the resulting system of equations. A database of the necessary coefficients for materials of interest was assembled using the PROPACEOS and ATBASE codes from Prism. The model was benchmarked against Prism's 1-D radiation hydrodynamics code HELIOS, and against experimental data obtained from HyperV's separately funded plasma jet accelerator development program. Work in the second funding cycle focused on extending the radiation diffusion model to full 3-D, continued development of the EMHD model, optimizing the direct-implicit model to speed up calculations, add in multiply ionized atoms, and improved the way boundary conditions are handled in LSP. These new LSP capabilities were then used, along with analytic calculations and Mach2 runs, to investigate plasma jet merging, plasma detachment and transport

  18. Rapid dynamics of general transcription factor TFIIB binding during preinitiation complex assembly revealed by single-molecule analysis

    Science.gov (United States)

    Zhang, Zhengjian; English, Brian P.; Grimm, Jonathan B.; Kazane, Stephanie A.; Hu, Wenxin; Tsai, Albert; Inouye, Carla; You, Changjiang; Piehler, Jacob; Schultz, Peter G.; Lavis, Luke D.; Revyakin, Andrey; Tjian, Robert

    2016-01-01

    Transcription of protein-encoding genes in eukaryotic cells requires the coordinated action of multiple general transcription factors (GTFs) and RNA polymerase II (Pol II). A “step-wise” preinitiation complex (PIC) assembly model has been suggested based on conventional ensemble biochemical measurements, in which protein factors bind stably to the promoter DNA sequentially to build a functional PIC. However, recent dynamic measurements in live cells suggest that transcription factors mostly interact with chromatin DNA rather transiently. To gain a clearer dynamic picture of PIC assembly, we established an integrated in vitro single-molecule transcription platform reconstituted from highly purified human transcription factors and complemented it by live-cell imaging. Here we performed real-time measurements of the hierarchal promoter-specific binding of TFIID, TFIIA, and TFIIB. Surprisingly, we found that while promoter binding of TFIID and TFIIA is stable, promoter binding by TFIIB is highly transient and dynamic (with an average residence time of 1.5 sec). Stable TFIIB–promoter association and progression beyond this apparent PIC assembly checkpoint control occurs only in the presence of Pol II–TFIIF. This transient-to-stable transition of TFIIB-binding dynamics has gone undetected previously and underscores the advantages of single-molecule assays for revealing the dynamic nature of complex biological reactions. PMID:27798851

  19. Evaluación de Varios Insecticidas para el Control del Cephaloleiaspcerca avagelineataPic, Plaga de la Palma Africana

    Directory of Open Access Journals (Sweden)

    Urueta Sandino Eduardo

    1974-04-01

    Full Text Available Resumen. Se efectuaron varios ensayos para determinar el efecto de carbofuran 1.0, 1.5 y 2. 0 kg I. A./ha; carbaril 1.5 y 2. 0 kg I. A. /ha; lindano 1.0 y 1.5 kg I. A. /ha; diazinon 0.5 lt I. A./ha; dicrotofos 0. 5 lt I. A. /ha; fosfamidon 0.6 lt. I. A/ha; y fention 0.5 lt I. A./ha, sobre adultos y larvas de Cephaloleiasp. cerca avagelineataPic., una plaga de la palma africana en Colombia. Todos los insecticidas fueron efectivos para controlar larvas de Cephaloleiasp. en cogollos, hasta por periodos de más de 30 días. El carbofuran 2.0 kg I. A./ha carbaril 2.0 kg l . A./ha y lindano 1. 5 kg I.A. /hafueron los productos más eficientes para controlar adultos de Cephaloleia. sp. protegiendo por 15 días las hojas más jóvenes. Dicrotofos 0.5 lt I. A./ha; diazinon0.5 lt l. A./ha; fention 0.5 itI. A./ha y fosfamidon 0.6 lt I. A/ha, aparentemente no fueron efectivos para controlar las formas adultas de Cephaloleiasp. Ninguno de los insecticidas fue fitotóxico para la palma africana. /Abstract. Several tests were carried out to determine the effectiveness of carbofuran 1. 0, 1.5 and 2.0 kg A.I./ha; carbaryl 1.5, 2.0 kg. A.I./ha; lindane 1.0, 1.5 kg. A.I./ha; phosphamidon 0.6 lt. A.I./ha; fenthion 0.5 lt. A.I./ha; dicrotophos 0.5 lt. A.I /ha; diazinon 0.5 lt. A.I./ha on larvae and adults of Cephaloleia. sp. near vagelineata Pic a Chrysomelidae that affects young oil palm (Elaeisguineensis leaves in Colombia. All of these insecticides controlled well Cepbaloleia sp. larvae for periods over a month. carbofuran 2 kg. A.I./ha; carbaryl 2kg. A.I./ha and lindane 1.5 kg. A. I./ha gave the best control of Cephaloleia. sp. adults, protecting young oil palm leaves up to 15 days. Dicrotophos 0.5 lts. A.I./ha; fenthion 0.5 lt. A. I./ha; phosphamidon 0.6 lt. A.I./ha; diazinon 0.5 lt. A.I./ha; apparently were not effective to control adults of Cephaloleia sp. None of the insecticides tested showed to be phytotoxic to the oil palm.

  20. Linear growth and nonlinear saturation of proton ring-driven instabilities in the inner magnetosphere: Linear theory and PIC simulations

    Science.gov (United States)

    Min, K.; Liu, K.; Gary, S. P.

    2015-12-01

    In the inner magnetosphere, the energy-dependent convection of ring current ions can lead to the ring-type proton velocity distributions with ∂fp(vperp)/∂vperp > 0 and ring speeds around the Alfvén speed. This ring-type velocity distribution is known to drive fast magnetosonic waves at propagation quasi-perpendicular to the background magnetic field B0 and, with sufficient temperature anisotropy, electromagnetic ion cyclotron (EMIC) waves at propagation parallel to B0. While there is an abundant literature on linear theory and computer simulations of EMIC waves driven by bi-Maxwellian ion distributions, the literature on the instabilities associated with ring-type proton velocity distributions in the inner magnetosphere is less substantial. Even less studied is the interplay of the two instabilities which lead to the growth of EMIC and fast magnetosonic waves, respectively. The goal of this paper is to provide a comprehensive picture of the instabilities responsible for the two types of waves and their interplay in the conditions of the inner magnetosphere, using linear dispersion theory and self-consistent particle-in-cell (PIC) simulations. For systematic analyses, two-component proton distributions fp = fr + fb are used, where fr represents a tenuous energetic proton velocity distribution with ∂fr(vperp)/∂vperp > 0 providing free energy and fb represents a dense Maxwellian background with sufficiently small beta corresponding to the inner magnetospheric condition. Both an ideal velocity ring and a partial shell with sinn-type pitch angle dependence will be considered for the fr component.

  1. Cleavage specificity analysis of six type II transmembrane serine proteases (TTSPs using PICS with proteome-derived peptide libraries.

    Directory of Open Access Journals (Sweden)

    Olivier Barré

    Full Text Available BACKGROUND: Type II transmembrane serine proteases (TTSPs are a family of cell membrane tethered serine proteases with unclear roles as their cleavage site specificities and substrate degradomes have not been fully elucidated. Indeed just 52 cleavage sites are annotated in MEROPS, the database of proteases, their substrates and inhibitors. METHODOLOGY/PRINCIPAL FINDING: To profile the active site specificities of the TTSPs, we applied Proteomic Identification of protease Cleavage Sites (PICS. Human proteome-derived database searchable peptide libraries were assayed with six human TTSPs (matriptase, matriptase-2, matriptase-3, HAT, DESC and hepsin to simultaneously determine sequence preferences on the N-terminal non-prime (P and C-terminal prime (P' sides of the scissile bond. Prime-side cleavage products were isolated following biotinylation and identified by tandem mass spectrometry. The corresponding non-prime side sequences were derived from human proteome databases using bioinformatics. Sequencing of 2,405 individual cleaved peptides allowed for the development of the family consensus protease cleavage site specificity revealing a strong specificity for arginine in the P1 position and surprisingly a lysine in P1' position. TTSP cleavage between R↓K was confirmed using synthetic peptides. By parsing through known substrates and known structures of TTSP catalytic domains, and by modeling the remainder, structural explanations for this strong specificity were derived. CONCLUSIONS: Degradomics analysis of 2,405 cleavage sites revealed a similar and characteristic TTSP family specificity at the P1 and P1' positions for arginine and lysine in unfolded peptides. The prime side is important for cleavage specificity, thus making these proteases unusual within the tryptic-enzyme class that generally has overriding non-prime side specificity.

  2. V-shaped ligand 1,3-bis(1-ethylbenzimidazol-2-yl)-2-thiapropane and manganese(II), cobalt(II) and copper(II) complexes: Synthesis, crystal structure, DNA-binding properties and antioxidant activities.

    Science.gov (United States)

    Wu, Huilu; Yang, Zaihui; Wang, Fei; Peng, Hongping; Zhang, Han; Wang, Cuiping; Wang, Kaitong

    2015-07-01

    A V-shaped ligand 1,3-bis(1-ethylbenzimidazol-2-yl)-2-thiapropane (bebt) and its transition metal complexes, [Mn(bebt)(pic)2]·CH3OH (pic=picrate) 1, [Co(bebt)2](pic)22 and [Cu(bebt)2](pic)2·2DMF 3, have been synthesized and characterized. The coordinate forms of complexes 1 and 2 are basically alike, which can be described as six-coordinated distorted octahedron. The geometric structure around Cu(II) atom can be described as distorted tetrahedral in complex 3. The DNA-binding properties of the ligand bebt and complexes have been investigated by electronic absorption, fluorescence, and viscosity measurements. The results suggest that bebt and complexes bind to DNA via an intercalative binding mode and the order of the binding affinity is 1<2<3complex 3 possess significant antioxidant activity against superoxide and hydroxyl radicals, and the scavenging effects of it are stronger than standard mannitol and vitamin C.

  3. Potencial alelopático de Tropaeolum majus L. na germinação e crescimento inicial de plântulas de picão-preto Allelophaty potential of Tropaeolum majus L on picão-preto seeds germination and initial seedling growth

    Directory of Open Access Journals (Sweden)

    Anelise Samara Nazari Formagio

    2012-01-01

    Full Text Available Objetivou-se com este estudo avaliar o potencial alelopático de extratos metanólicos de folhas, flores e raízes de capuchinha (Tropaeolum majus L. sobre a germinação de sementes e o crescimento inicial de plântulas de picão-preto. O extrato metanólico com melhor potencial de inibição foi submetido a particionamento, resultando nas frações hexânica, clorofórmica, acetato de etila e hidrometanólica e posterior caracterização pelo espectro de absorção na região do infravermelho (IV. O efeito alelopático foi avaliado sobre as sementes de picão-preto, as quais foram distribuídas sobre papel germitest umedecido com 2mL dos extratos e mantidas em germinador do tipo B.O.D. regulado a temperatura de 25°C e luz branca constante, sendo que as sementes imersas diretamente em água constituíram o tratamento controle. A avaliação da qualidade da semente foi realizada pelos testes de germinação e vigor (primeira contagem e comprimento de raiz primária e de hipocótilo das plântulas, em delineamento inteiramente ao acaso. O potencial alelopático das folhas de capuchinha foi maior em relação às demais partes da planta sobre a germinação das sementes, comprimento de hipocótilo e de raiz das plântulas de picão-preto. Estes efeitos podem estar associados à presença de grupos químicos polares, pois à medida que se aumentou a polaridade dos solventes detectou-se maior efeito inibitório sobre a germinação e o crescimento inicial de plântulas de picão-preto.This research aimed to evaluate the metanolic extracts allelopathic potential from leaves, flowers and roots of capuchinha (Tropaeolum majus L. on picão-preto seeds germination and initial seedling growth. The best inhibitor metanolic extract was fractioned, in hexanic, cloroformic, etil acetate and hidrometanolic fractions and it was characterized through absorption spectrum using mid-infrared. To evaluate the allelopathic effect of metanolic extracts and the

  4. PIC16F84 MİKRODENETLEYİCİSİ KULLANILARAK CİHAZLARIN TELEFON İLE KONTROLÜNE BİR UYGULAMA

    OpenAIRE

    Yakar, Rahman; Etem KÖKLÜKAYA

    2001-01-01

    Bu çalışmada ev, işyeri vb. yerlerdekicihaziarın telefon vasıtası ile kontrol edilebilmesi içinPIC16F84 Mikrodenetleyici kullanılarak dizaynedilen kontrol kartı devresi ile telefon hattının uygunşartlar altında açıiabilmesi için tasarlanan elektronikdevre gösterilmiş, aynca programın işleyişiaçıklanmıştır.

  5. 基于PIC18F4550的USB数据采集系统的设计及应用

    Institute of Scientific and Technical Information of China (English)

    郭夏夏; 俞水锋; 田社平

    2013-01-01

    本文介绍了一种基于USB接口的数据采集系统,该系统采用具备USB通信接口的PIC18F4550单片机作为微控制器,16位串行ADS8509作为模数转换器.详细介绍了系统硬件和软件开发过程,并用实例验证了该设计的有效性.

  6. PIC16F84 MİKRODENETLEYİCİSİ KULLANILARAK CİHAZLARIN TELEFON İLE KONTROLÜNE BİR UYGULAMA

    Directory of Open Access Journals (Sweden)

    Rahman Yakar

    2001-12-01

    Full Text Available Bu çalışmada ev, işyeri vb. yerlerdekicihaziarın telefon vasıtası ile kontrol edilebilmesi içinPIC16F84 Mikrodenetleyici kullanılarak dizaynedilen kontrol kartı devresi ile telefon hattının uygunşartlar altında açıiabilmesi için tasarlanan elektronikdevre gösterilmiş, aynca programın işleyişiaçıklanmıştır.

  7. 基于PIC单片机控制的智能巡线小车%Small Intelligent Patrol Line Vehicle Based on PIC Single Chip Processor Control

    Institute of Scientific and Technical Information of China (English)

    肖立; 佟仕忠; 丁启敏; 毕雅宁

    2005-01-01

    介绍了一种智能巡线小车的制作方法,给出了控制系统的硬件电路和软件设计.控制系统的硬件电路部分主要包括控制器、传感器和电机驱动芯片.控制器和传感器分别采用8位PIC系列单片机PIC16F84A和光电判读器TLP909.巡线小车的驱动采用直流电机.

  8. Connect into the CAN Net Via RS232 Interface Based on PIC18F4580%基于RS232接口接入CAN的实现

    Institute of Scientific and Technical Information of China (English)

    丁亮

    2008-01-01

    CAN是现在汽车电子、工业控制领域中应用非常广泛的一种网络.论文介绍了利用Microchip公司的PIC18F4580微控制器,使用PC机中的RS232接口和Windows系统中自带的超级终端软件将PC机接入CAN,从而提供了一种对CAN中各节点的测试与评估的低成本方法.

  9. G2DEM: a parallel two-dimensional electromagnetic PIC code for the study of electron-cyclotron instabilities of relativistic electron beams in cylindrical cavities

    Energy Technology Data Exchange (ETDEWEB)

    Jost, G.; Tran, T.M.; Appert, K. [Ecole Polytechnique Federale, Lausanne (Switzerland). Centre de Recherche en Physique des Plasma (CRPP); Wuethrich, S. [CRAY Research, PATP/PSE, EPFL, Lausanne (Switzerland)

    1996-12-01

    A two-dimensional PIC code aimed at the investigation of electron-cyclotron beam instabilities in gyrotrons and their effects on the beam quality is presented. The code is based on recently developed techniques for handling charge conservation and open boundaries and uses an electromagnetic field which is decomposed in its transverse magnetic (TM) and electric (TE) components. The code has been implemented on the massively parallel computer CRAY T3D, and on the CRAY Y-MP. (author) figs., tabs., refs.

  10. Effects of bpV(pic) and bpV(phen) on H9c2 cardiomyoblasts during both hypoxia/reoxygenation and H2O2-induced injuries.

    Science.gov (United States)

    Tian, Youqing; Daoud, Abdelkader; Shang, Jing

    2012-03-01

    Reactive oxygen species (ROS) are involved in myocardial injury. ROS are known to inactivate lipid phosphatase and tension homolog on chromosome 10 (PTEN), an enzyme that increases apoptosis in neonatal cardiomyocytes. BpV(pic) and bpV(phen), two bisperoxovanadium molecules and PTEN inhibitors, may be involved in limiting myocardial infarction. To compare the protective effects of bpV(pic) and bpV(phen) on ROS-induced cardiomyocyte injury and their possible mechanisms, we selected two popular models of hypoxia/reoxygenation (H/R) and H2O2-induced injury in H9c2 cardiomyoblasts to investigate their effects against injury. We found that pre-treatment with bpV(pic) and bpV(phen) increased the viability and protected the morphology of H9c2 cells under the conditions of H/R and H2O2 by inhibiting LDH release, apoptosis and caspases 3/8/9 activities. However, their respective inhibitory abilities in the two models were different, suggesting that the quantity of ROS from the two models might be different. However, the conflict between ROS and PTEN may affect the action of bpV(pic) and bpV(phen). Taken together, the results demonstrate that bpV(pic) and bpV(phen) have inhibitory effects on oxidative stress-induced cardiomyocyte injury that may be partially modulated by the action of ROS on PTEN.

  11. Design Study on a G-Band Folded Waveguide Traveling Wave Tube Amplifier Using 3D CFDTD PIC Method for Future Advanced Imaging Applications

    Science.gov (United States)

    Lin, M. C.; Song, Heather; Shin, Jinwoo; So, Joonho

    2016-10-01

    Design study on a G-band (220 GHz) folded waveguide traveling wave tube (FWTWT) is presented. Due to ease of fabrication, wide bandwidth, and versatility in operation, a FWTWT structure was chosen for future advanced broadband amplifier for imaging applications. The cold test simulations were carried out employing finite element method (FEM) to determine dispersion relation, circuit dimensions, and operating beam parameters of the device. Beam optics study was performed to eliminate interception to the circuit wall and minimize beam scalloping. While precise control of beam location and size is very important to device performance, hot test simulations based on a 3D conformal finite-difference time-domain (CFDTD) particle-in-cell (PIC) method have been extensively used to predict performance of the beam transport and stability characteristics in order to optimize the electrical operating parameters. The 3D CFDTD PIC simulations of the full model have demonstrated a greater than 26 dB large signal gain at 220 GHz and beam voltage of approximately 18 kV. The effects of beam filling ratio, magnetic field, and beam interception on the gain have been studied in considerable detail and will be presented.

  12. 基于PIC单片机的咖啡机控制系统的研制%Design of Coffee machine control system based on PIC microcontroller

    Institute of Scientific and Technical Information of China (English)

    李小琴; 陈光绒

    2012-01-01

      本文设计并制作了一种具有多种功能选择模式的咖啡机控制电路,以单片机PIC16C74为主控芯片,通过水位压力开关对进水管进行水位检测,进水完成后开始加热水,通过温度传感器检测水温的度数。根据口味不同,可设置6种泡咖啡的模式,享受不同味道的咖啡。%  This paper design and product a coffee machine control circuit with a variety of function selection mode,to the microcontrol er PIC16C74 chip,through the water level pressure switch detect the water level on the inlet pipe,water heating after completion of water.through the temperature sensor test the water temperature in degrees.Depending on your tastes can accommodate six coffee mode,enjoy the different flavors of coffee.

  13. Hybrid Particle-In-Cell (PIC) simulation of heat transfer and ionization balance in overdense plasmas irradiated by subpicosecond pulse lasers

    Energy Technology Data Exchange (ETDEWEB)

    Zhidkov, A.; Sasaki, Akira [Japan Atomic Energy Research Inst., Neyagawa, Osaka (Japan). Kansai Research Establishment

    1998-11-01

    A 1D hybrid electromagnetic particle-in-cell code with new methods to include particle collisions and atomic kinetics is developed and applied to ultra-short-pulse laser plasma interaction. Using the Langevin equation to calculate the Coulomb collision term, the present code is shown to be fast and stable in calculating the particle motion in the PIC simulation. Furthermore, by noting that the scale length of the change of atomic kinetics is much longer than the Debye radius, we calculate ionization and X-ray emission on kinetics cells, which are determined by averaging plasma parameters such as the electron density and energy over number of PIC cells. The absorption of short-pulse laser by overdense plasmas is calculated in self-consistent manner, including the effect of rapid change of density and temperature caused by instantaneous heating and successive fast ionization of the target material. The calculated results agree well with those obtained from the Fokker-Planck simulation as well as experiments, for non-local heat transport in plasmas with steep temperature gradient, and for the absorption of a short laser pulse by solid density targets. These results demonstrate usefulness of the code and the computational method therein for understanding of physics of short pulse laser plasma interaction experiments, and for application to the gain calculation of short-pulse laser excited X-ray laser as well. (author)

  14. Controlling the Numerical Cerenkov Instability in PIC simulations using a customized finite difference Maxwell solver and a local FFT based current correction

    CERN Document Server

    Li, Fei; Xu, Xinlu; Fiuza, Frederico; Decyk, Viktor K; Dalichaouch, Thamine; Davidson, Asher; Tableman, Adam; An, Weiming; Tsung, Frank S; Fonseca, Ricardo A; Lu, Wei; Mori, Warren B

    2016-01-01

    In this paper we present a customized finite-difference-time-domain (FDTD) Maxwell solver for the particle-in-cell (PIC) algorithm. The solver is customized to effectively eliminate the numerical Cerenkov instability (NCI) which arises when a plasma (neutral or non-neutral) relativistically drifts on a grid when using the PIC algorithm. We control the EM dispersion curve in the direction of the plasma drift of a FDTD Maxwell solver by using a customized higher order finite difference operator for the spatial derivative along the direction of the drift ($\\hat 1$ direction). We show that this eliminates the main NCI modes with moderate $\\vert k_1 \\vert$, while keeps additional main NCI modes well outside the range of physical interest with higher $\\vert k_1 \\vert$. These main NCI modes can be easily filtered out along with first spatial aliasing NCI modes which are also at the edge of the fundamental Brillouin zone. The customized solver has the possible advantage of improved parallel scalability because it can...

  15. Power-line Communication System Using PIC%基于PIC单片机的电力线载波系统的探讨

    Institute of Scientific and Technical Information of China (English)

    许国强; 冯秀玲

    2013-01-01

    随着电力线载波技术的不断发展,该技术已经得到广泛应用。尤其是国家电网的不断升级、改造,为电力线载波通信提供了重要的契机。提出一种基于PIC单片机的简单的电力线载波系统,通过PIC单片机实现数据的生成和接口电路。该系统适用于本地的数据传输。如本地自动抄表系统、消防安全报警系统等。%With the development of Power-line Communication (PLC), the technology has been widely used. The transformation of the national grid provides an important opportunity for Power-line Communication. In this paper we present a simple hardware implementation for a PLC system using a Peripheral Interface Controller (PIC) microcontroller which provides data generation and interfacing. The system is suitable for data communications within a local power network area, such as remote automatic meter reading, fire and security alarm control, etc.

  16. Synthesis and Structure of a Ternary Copper(II) Complex with Mixed Ligands of Diethylenetriamine and Picrate: DNA/Protein-Binding Property and In Vitro Anticancer Activity Studies.

    Science.gov (United States)

    Shi, Ya-Ning; Zheng, Kang; Zhu, Ling; Li, Yan-Tuan; Wu, Zhi-Yong; Yan, Cui-Wei

    2015-05-01

    Based on the importance of the design and synthesis of transition metal complexes with noncovalent DNA/protein-binding abilities in the field of metallo pharmaceuticals, a new mononuclear ternary copper(II) complex with mixed ligands of diethylenetriamine (dien) and picrate anion (pic), identified as [Cu(dien)(pic)](pic), was synthesized and characterized by elemental analysis, molar conductivity measurement, infrared spectrum, electronic spectral studies, and single-crystal X-ray diffractometry. The structure analysis reveals that the copper(II) complex crystallizes in the monoclinic space group P21 /c, and the copper(II) ion has a distorted square pyramidal coordination geometry. A two-dimensional supramolecular structure is formed through hydrogen bonds. The DNA/bovine serum albumin (BSA)-binding properties of the complex are explored, indicating that the complex can interact with herring sperm DNA via intercalation mode and bind to BSA responsible for quenching of tryptophan fluorescence by static quenching mechanism. The in vitro anticancer activity shows that the copper(II) complex is active against the selected tumor cell lines.

  17. The 3D Pelvic Inclination Correction System (PICS): A universally applicable coordinate system for isovolumetric imaging measurements, tested in women with pelvic organ prolapse (POP).

    Science.gov (United States)

    Reiner, Caecilia S; Williamson, Tom; Winklehner, Thomas; Lisse, Sean; Fink, Daniel; DeLancey, John O L; Betschart, Cornelia

    2017-07-01

    In pelvic organ prolapse (POP), the organs are pushed downward along the lines of gravity, so measurements along this longitudinal body axis are desirable. We propose a universally applicable 3D coordinate system that corrects for changes in pelvic inclination and that allows the localization of any point in the pelvis at rest or under dynamic conditions on magnetic resonance images (MRI) of pelvic floor disorders in a scanner- and software independent manner. The proposed 3D coordinate system called 3D Pelvic Inclination Correction System (PICS) is constructed utilizing four bony landmark points, with the origin set at the inferior pubic point, and three additional points at the sacrum (sacrococcygeal joint) and both ischial spines, which are clearly visible on MRI images. The feasibility and applicability of the moving frame was evaluated using MRI datasets from five women with pelvic organ prolapse, three undergoing static MRI and two undergoing dynamic MRI of the pelvic floor in a supine position. The construction of the coordinate system was performed utilizing the selected landmarks, with an initial implementation completed in MATLAB. In all cases the selected landmarks were clearly visible, with the construction of the 3D PICS and measurement of pelvic organ positions performed without difficulty. The resulting distance from the organ position to the horizontal PICS plane was compared to a traditional measure based on standard measurements in 2D slices. The two approaches demonstrated good agreement in each of the cases. The developed approach makes quantitative assessment of pelvic organ position in a physiologically relevant 3D coordinate system possible independent of pelvic movement relative to the scanner. It allows the accurate study of the physiologic range of organ location along the body axis ("up or down") as well as defects of the pelvic sidewall or birth-related pelvic floor injuries outside the midsagittal plane, not possible before in a 2D

  18. Периферия 16-разрядных микроконтроллеров Microchip. Сравнение микроконтроллеров PIC18F, PIC24F и PIC24H

    OpenAIRE

    Лобачев, Дмитрий; Сафронов, Алексей

    2007-01-01

    Высокопроизводительные 16-разрядные семейства PIC24F и PIC24H были разработаны компанией Microchip для расширения существующей линейки микроконтроллеров. Предоставляя пользователю хорошие вычислительные возможности и значительно переработанные периферийные модули, семейства PIC24 позволяют увеличить функциональность разрабатываемых устройств. С другой стороны, микроконтроллеры PIC24 разработаны таким образом, чтобы сделать переход пользователя с существующих семейств на новые более легким....

  19. Interface between 40S exit channel protein uS7/Rps5 and eIF2α modulates start codon recognition in vivo

    Science.gov (United States)

    Visweswaraiah, Jyothsna; Hinnebusch, Alan G

    2017-01-01

    The eukaryotic pre-initiation complex (PIC) bearing the eIF2·GTP·Met-tRNAiMet ternary complex (TC) scans the mRNA for an AUG codon in favorable context. AUG recognition evokes rearrangement of the PIC from an open, scanning to a closed, arrested conformation. Cryo-EM reconstructions of yeast PICs suggest remodeling of the interface between 40S protein Rps5/uS7 and eIF2α between open and closed states; however, its importance was unknown. uS7 substitutions disrupting eIF2α contacts favored in the open complex increase initiation at suboptimal sites, and uS7-S223D stabilizes TC binding to PICs reconstituted with a UUG start codon, indicating inappropriate rearrangement to the closed state. Conversely, uS7-D215 substitutions, perturbing uS7-eIF2α interaction in the closed state, confer the opposite phenotypes of hyperaccuracy and (for D215L) accelerated TC dissociation from reconstituted PICs. Thus, remodeling of the uS7/eIF2α interface appears to stabilize first the open, and then the closed state of the PIC to promote accurate AUG selection in vivo. DOI: http://dx.doi.org/10.7554/eLife.22572.001 PMID:28169832

  20. A Performance-Prediction Model for PIC Applications on Clusters of Symmetric MultiProcessors: Validation with Hierarchical HPF+OpenMP Implementation

    Directory of Open Access Journals (Sweden)

    Sergio Briguglio

    2003-01-01

    Full Text Available A performance-prediction model is presented, which describes different hierarchical workload decomposition strategies for particle in cell (PIC codes on Clusters of Symmetric MultiProcessors. The devised workload decomposition is hierarchically structured: a higher-level decomposition among the computational nodes, and a lower-level one among the processors of each computational node. Several decomposition strategies are evaluated by means of the prediction model, with respect to the memory occupancy, the parallelization efficiency and the required programming effort. Such strategies have been implemented by integrating the high-level languages High Performance Fortran (at the inter-node stage and OpenMP (at the intra-node one. The details of these implementations are presented, and the experimental values of parallelization efficiency are compared with the predicted results.

  1. 基于PIC18F4550和DirectDraw技术的廉价高速虚拟示波器

    Institute of Scientific and Technical Information of China (English)

    邢文生; 张宏

    2010-01-01

    因价格原因,廉价虚拟示波器存在数据采集速度慢、数据传输到计算机的速度慢、波形显示反应慢等瓶颈等问题.文章使用A/D转换芯片MAX1002实现模拟量的高速采集,使用USB单片机PIC18F4550实现数据的高速传输,使用DirectDraw技术解决显示速度慢问题.文章详细论述了系统的硬件与软件设计.

  2. Plasma density enhancement in atmospheric-pressure dielectric-barrier discharges by high-voltage nanosecond pulse in the pulse-on period: a PIC simulation

    Science.gov (United States)

    Sang, Chaofeng; Sun, Jizhong; Wang, Dezhen

    2010-02-01

    A particle-in-cell (PIC) plus Monte Carlo collision simulation is employed to investigate how a sustainable atmospheric pressure single dielectric-barrier discharge responds to a high-voltage nanosecond pulse (HVNP) further applied to the metal electrode. The results show that the HVNP can significantly increase the plasma density in the pulse-on period. The ion-induced secondary electrons can give rise to avalanche ionization in the positive sheath, which widens the discharge region and enhances the plasma density drastically. However, the plasma density stops increasing as the applied pulse lasts over certain time; therefore, lengthening the pulse duration alone cannot improve the discharge efficiency further. Physical reasons for these phenomena are then discussed.

  3. 基于PIC16F73单片机和ADS8341的SPI通信软硬件实现

    Institute of Scientific and Technical Information of China (English)

    党瑞荣; 苗强; 汤小松

    2008-01-01

    本文介绍了PIC16F73单片机通过两种方式和模数转换器件ADS8341实现SPI通信,它们分别是软件实现和硬件实现。软件实现方法能很好的解决片内无SPI接口的PIC单片机与带有SPI接口的从机实现数据交换,而硬件方法能很方便快速地实现带有SPI口的PIC单片机和带有SPI口的从机进行数据通信。

  4. The Design of Measuring Speed Based on SCM PIC%基于PIC单片机的测速系统设计

    Institute of Scientific and Technical Information of China (English)

    谭逢富; 侯再红; 季永华; 张守川

    2008-01-01

    本文介绍了一种基于低功耗芯片PIC16F84A的自动测速系统的设计,文中给出了系统的硬件设计和软件设计.包括键盘、计数、数据处理、代码转换、显示这几个部分.此系统采用了溢出计数和动态显示的方法.该测速系统具有低成本、高精度、高可靠性等优点.

  5. Carney Complex

    Science.gov (United States)

    ... Types of Cancer > Carney Complex Request Permissions Carney Complex Approved by the Cancer.Net Editorial Board , 11/2015 What is Carney complex? Carney complex is a hereditary condition associated with: ...

  6. Shell and core cross-linked poly(L-lysine)/poly(acrylic acid) complex micelles.

    Science.gov (United States)

    Hsieh, Yi-Hsuan; Hsiao, Yung-Tse; Jan, Jeng-Shiung

    2014-12-21

    We report the versatility of polyion complex (PIC) micelles for the preparation of shell and core cross-linked (SCL and CCL) micelles with their surface properties determined by the constituent polymer composition and cross-linking agent. The negatively and positively charged PIC micelles with their molecular structure and properties depending on the mixing weight percentage and polymer molecular weight were first prepared by mixing the negatively and positively charged polyions, poly(acrylic acid) (PAA) and poly(L-lysine) (PLL). The feasibility of preparing SCL micelles was demonstrated by cross-linking the shell of the negatively and positively charged micelles using cystamine and genipin, respectively. The core of the micelles can be cross-linked by silica deposition to stabilize the assemblies. The shell and/or core cross-linked micelles exhibited excellent colloid stability upon changing solution pH. The drug release from the drug-loaded SCL micelles revealed that the controllable permeability of the SCL micelles can be achieved by tuning the cross-linking degree and the SCL micelles exhibited noticeable pH-responsive behavior with accelerated release under acidic conditions. With the versatility of cross-linking strategies, it is possible to prepare a variety of SCL and CCL micelles from PIC micelles.

  7. Molecular basis of transcription initiation in Archaea.

    Science.gov (United States)

    De Carlo, Sacha; Lin, Shih-Chieh; Taatjes, Dylan J; Hoenger, Andreas

    2010-01-01

    Compared with eukaryotes, the archaeal transcription initiation machinery-commonly known as the Pre-Initiation Complex-is relatively simple. The archaeal PIC consists of the TFIIB ortholog TFB, TBP, and an 11-subunit RNA polymerase (RNAP). The relatively small size of the entire archaeal PIC makes it amenable to structural analysis. Using purified RNAP, TFB, and TBP from the thermophile Pyrococcus furiosus, we assembled the biochemically active PIC at 65ºC. The intact archaeal PIC was isolated by implementing a cross-linking technique followed by size-exclusion chromatography, and the structure of this 440 kDa assembly was determined using electron microscopy and single-particle reconstruction techniques. Combining difference maps with crystal structure docking of various sub-domains, TBP and TFB were localized within the macromolecular PIC. TBP/TFB assemble near the large RpoB subunit and the RpoD/L "foot" domain behind the RNAP central cleft. This location mimics that of yeast TBP and TFIIB in complex with yeast RNAP II. Collectively, these results define the structural organization of the archaeal transcription machinery and suggest a conserved core PIC architecture.

  8. Research on Discharge Channel Simulation of Nano Electrical Discharge Machining and its Mechanism based on PIC-MCC Method%基于PIC-MCC的纳米放电加工放电通道模拟及其机理研究

    Institute of Scientific and Technical Information of China (English)

    陈寅; 赵万生

    2012-01-01

    This paper simulates the particle movement and field change in plasma channel during a nano-scale discharging process using PIC-MCC method and secondary emission model of electrons. Comparison between nano-scale and micro-scale discharging process was made in order to analyze the phenomenon and mechanism of nano-scale electrical discharge machining. The existence of best breakdown pressure during a gas discharging process was also verified using the simulation model.%以纳米尺度放电加工为对象,采用粒子模拟法和蒙特卡罗碰撞模型(PIC-MCC),结合二次电子发射模型,对纳米级等离子体放电通道击穿过程的粒子运动、电磁场变化等情况进行模拟仿真,对比纳米尺度与传统微细尺度放电通道击穿过程的异同,讨论纳米尺度下放电加工的新特性,并对气体电离最佳击穿气压的存在性进行了验证.

  9. Design of short-range wireless transmission system based on PIC16F726 and nRF24L01%基于PIC16F726和nRF24L01的短距离无线传输系统设计

    Institute of Scientific and Technical Information of China (English)

    张肖汉; 陈以; 李明伟

    2012-01-01

    In order to meet the market demand of short-range wireless communication, using the PIC16F726 and nRF24L01 chip to design short-range wireless transmission system, and this paper also presents the hardware design and software design processes. The test results show that the system has achieved a two-way communication and has got reliable performance , which is strong practical as well as cost-effective.%为了满足当前短距离无线通信的市场需求,采用PIC16F726和nRF24L01芯片设计短距离无线传输系统,给出了硬件设计方案和软件设计流程。测试结果表明,系统实现了双向通信,性能稳定可靠,实用性强,性价比高。

  10. RNA polymerase II components and Rrn7 form a preinitiation complex on the HomolD box to promote ribosomal protein gene expression in Schizosaccharomyces pombe.

    Science.gov (United States)

    Montes, Matías; Moreira-Ramos, Sandra; Rojas, Diego A; Urbina, Fabiola; Käufer, Norbert F; Maldonado, Edio

    2017-02-01

    In Schizosaccharomyces pombe, ribosomal protein gene (RPG) promoters contain a TATA box analog, the HomolD box, which is bound by the Rrn7 protein. Despite the importance of ribosome biogenesis for cell survival, the mechanisms underlying RPG transcription remain unknown. In this study, we found that components of the RNA polymerase II (RNAPII) system, consisting of the initiation or general transcription factors (GTFs) TFIIA, IIB, IIE, TATA-binding protein (TBP) and the RNAPII holoenzyme, interacted directly with Rrn7 in vitro, and were able to form a preinitiation complex (PIC) on the HomolD box. PIC complex formation follows an ordered pathway on these promoters. The GTFs and RNAPII can also be cross-linked to HomolD-containing promoters in vivo. In an in vitro reconstituted transcription system, RNAPII components and Rrn7 were necessary for HomolD-directed transcription. The Mediator complex was required for basal transcription from those promoters in whole cell extract (WCE). The Med17 subunit of Mediator also can be cross-linked to the promoter region of HomolD-containing promoters in vivo, suggesting the presence of the Mediator complex on HomolD box-containing promoters. Together, these data show that components of the RNAPII machinery and Rrn7 participate in the PIC assembly on the HomolD box, thereby directing RPG transcription. © 2017 Federation of European Biochemical Societies.

  11. Complex Beauty

    OpenAIRE

    Franceschet, Massimo

    2014-01-01

    Complex systems and their underlying convoluted networks are ubiquitous, all we need is an eye for them. They pose problems of organized complexity which cannot be approached with a reductionist method. Complexity science and its emergent sister network science both come to grips with the inherent complexity of complex systems with an holistic strategy. The relevance of complexity, however, transcends the sciences. Complex systems and networks are the focal point of a philosophical, cultural ...

  12. Systemic delivery of siRNA by actively targeted polyion complex micelles for silencing the E6 and E7 human papillomavirus oncogenes.

    Science.gov (United States)

    Nishida, Haruka; Matsumoto, Yoko; Kawana, Kei; Christie, R James; Naito, Mitsuru; Kim, Beob Soo; Toh, Kazuko; Min, Hyun Su; Yi, Yu; Matsumoto, Yu; Kim, Hyun Jin; Miyata, Kanjiro; Taguchi, Ayumi; Tomio, Kensuke; Yamashita, Aki; Inoue, Tomoko; Nakamura, Hiroe; Fujimoto, Asaha; Sato, Masakazu; Yoshida, Mitsuyo; Adachi, Katsuyuki; Arimoto, Takahide; Wada-Hiraike, Osamu; Oda, Katsutoshi; Nagamatsu, Takeshi; Nishiyama, Nobuhiro; Kataoka, Kazunori; Osuga, Yutaka; Fujii, Tomoyuki

    2016-06-10

    Human papillomavirus (HPV) E6 and E7 oncogenes are essential for the immortalization and maintenance of HPV-associated cancer and are ubiquitously expressed in cervical cancer lesions. Small interfering RNA (siRNA) coding for E6 and E7 oncogenes is a promising approach for precise treatment of cervical cancer, yet a delivery system is required for systemic delivery to solid tumors. Here, an actively targeted polyion complex (PIC) micelle was applied to deliver siRNAs coding for HPV E6/E7 to HPV cervical cancer cell tumors in immune-incompetent tumor-bearing mice. A cell viability assay revealed that both HPV type 16 and 18 E6/E7 siRNAs (si16E6/E7 and si18E6/E7, respectively) interfered with proliferation of cervical cancer cell lines in an HPV type-specific manner. A fluorescence imaging biodistribution analysis further revealed that fluorescence dye-labeled siRNA-loaded PIC micelles efficiently accumulated within the tumor mass after systemic administration. Ultimately, intravenous injection of si16E6/E7 and si18E6/E7-loaded PIC micelles was found to significantly suppress the growth of subcutaneous SiHa and HeLa tumors, respectively. The specific activity of siRNA treatment was confirmed by the observation that p53 protein expression was restored in the tumors excised from the mice treated with si16E6/E7- and si18E6/E7-loaded PIC micelles for SiHa and HeLa tumors, respectively. Therefore, the actively targeted PIC micelle incorporating HPV E6/E7-coding siRNAs demonstrated its therapeutic potential against HPV-associated cancer. Copyright © 2016 Elsevier B.V. All rights reserved.

  13. A seven-coordinated manganese(II) complex with V-shaped ligand bis(N-benzylbenzimidazol-2-ylmethyl)benzylamine: synthesis, structure, DNA-binding properties and antioxidant activities.

    Science.gov (United States)

    Wu, Huilu; Yuan, Jingkun; Bai, Ying; Wang, Hua; Pan, Guolong; Kong, Jin

    2012-11-05

    A manganese(II) complex of the type, [MnL(pic)(2)]·H(2)O, was obtained by the reaction of the V-shaped ligand bis(N-benzylbenzimidazol-2-ylmethyl)benzylamine (L) with Mn(pic)(2) (pic=picrate). The ligand L and Mn(II) complex were confirmed on the basis of elemental analysis, molarconductivities, (1)H NMR, IR, UV-vis spectra and X-ray crystallography. Single-crystal X-ray revealed that central Mn(II) atom is seven-coordinate with a MnN(3)O(4) environment, in which ligand L acts as a tridentate N-donor. The remaining coordination sites were occupied by four O atoms afforded by two picrate anion. Interaction of the free ligand L and Mn(II) complex with DNA were investigated by spectrophotometric methods and viscosity measurements. The results suggested that both ligand L and Mn(II) complex bind to DNA in an intercalative binding mode, and DNA-binding affinity of the Mn(II) complex is stronger than that of ligand L. Moreover, antioxidant assay in vitro shows the Mn(II) complex possesses significant antioxidant activities.

  14. PIC-1/SUMO-1-Modified PML-Retinoic Acid Receptor α Mediates Arsenic Trioxide-Induced Apoptosis in Acute Promyelocytic Leukemia

    Science.gov (United States)

    Sternsdorf, Thomas; Puccetti, Elena; Jensen, Kirsten; Hoelzer, Dieter; Will, Hans; Ottmann, Oliver Gerhard; Ruthardt, Martin

    1999-01-01

    Fusion proteins involving the retinoic acid receptor α (RARα) and PML or PLZF nuclear protein are the genetic markers of acute promyelocytic leukemia (APL). APLs with PML-RARα or PLZF-RARα fusion protein differ only in their response to retinoic acid (RA) treatment: the t(15;17) (PML-RARα-positive) APL blasts are sensitive to RA in vitro, and patients enter disease remission after RA treatment, while those with t(11;17) (PLZF-RARα-positive) APLs do not. Recently it has been shown that complete remission can be achieved upon treatment with arsenic trioxide (As2O3) in PML-RARα-positive APL, even when the patient has relapsed and the disease is RA resistant. This appears to be due to apoptosis induced by As2O3 in the APL blasts by poorly defined mechanisms. Here we report that (i) As2O3 induces apoptosis only in cells expressing the PML-RARα, not the PLZF-RARα, fusion protein; (ii) PML-RARα is partially modified by covalent linkage with a PIC-1/SUMO-1-like protein prior to As2O3 treatment, whereas PLZF-RARα is not; (iii) As2O3 treatment induces a change in the modification pattern of PML-RARα toward highly modified forms; (iv) redistribution of PML nuclear bodies (PML-NBs) upon As2O3 treatment is accompanied by recruitment of PIC-1/SUMO-1 into PML-NBs, probably due to hypermodification of both PML and PML-RARα; (v) As2O3-induced apoptosis is independent of the DNA binding activity located in the RARα portion of the PML-RARα fusion protein; and (vi) the apoptotic process is bcl-2 and caspase 3 independent and is blocked only partially by a global caspase inhibitor. Taken together, these data provide novel insights into the mechanisms involved in As2O3-induced apoptosis in APL and predict that treatment of t(11;17) (PLZF-RARα-positive) APLs with As2O3 will not be successful. PMID:10373566

  15. Complexity explained

    CERN Document Server

    Erdi, Peter

    2008-01-01

    This book explains why complex systems research is important in understanding the structure, function and dynamics of complex natural and social phenomena. Readers will learn the basic concepts and methods of complex system research.

  16. Finite-Element 2D and 3D PIC Modeling of RF Devices with Applications to Multipacting

    CERN Document Server

    De Ford, John F; Petillo, John

    2005-01-01

    Multipacting currently limits the performance of many high power radio-frequency (RF) devices, particularly couplers and windows. Models have helped researchers understand and mitigate this problem in 2D structures, but useful multipacting models for complicated 3D structures are still a challenge. A combination of three recent technologies that have been developed in the Analyst and MICHELLE codes begin to address this challenge: high-order adaptive finite-element RF field calculations, advanced particle tracking on unstructured grids, and comprehensive secondary emission models. Analyst employs high-order adaptive finite-element methods to accurately compute driven RF fields and eigenmodes in complex geometries, particularly near edges, corners, and curved surfaces. To perform a multipacting analysis, we use the mesh and fields from Analyst in a modified version of the self-consistent, finite-element gun code MICHELLE. MICHELLE has both a fast, accurate, and reliable particle tracker for unstructured grids ...

  17. PIC单片机控制下的无线模块自主选频数据传输%Independent Frequency Selection Data Transmission Based on Wireless Module Controlled by PIC MCU

    Institute of Scientific and Technical Information of China (English)

    蒲林蒸; 林东

    2013-01-01

    提出一种采用PIC16系列单片机和CC2500无线射频芯片的自主选频无线数据传输系统的设计方法,包括系统硬件电路设计和软件实现.系统具有自主选频功能,解决CC2500在ISM频段内由于同频干扰而产生的频率冲突问题.%A PIC16 MCU and CC2500 radio frequency (RF) chip self-selected frequency wireless data transmission system design method is presented in this paper, including system hardware circuit design and software implementation. As the system has independent frequency selection function, the frequency conflict is solved due to co-channel interference in the ISM band frequency.

  18. Design of Electric Bike Control System Based on PIC%基于PIC单片机的电动自行车控制系统设计

    Institute of Scientific and Technical Information of China (English)

    李胤昌; 郑日荣

    2009-01-01

    介绍以单片机PIC16F72为核心的电动自行车用无刷直流电动机控制系统的设计.该系统采用电流与速度双闭环控制的结构,其中电流调节器用传统的PI调节器,速度调节器为改进的PI调节器.实验验证了此设计方案的可行性和优越性,即控制电路简洁,器件少,成本低,保护措施可靠,提高了系统的控制精度.该设计对无刷直流电机在其他领域的应用有一定的帮助和借鉴,具有广泛的现实意义.该系统速度环采用改进型的PI调节器控制,且通过软件运用算法测速,实现转速反馈,既简化电路又节省成本.

  19. NUMERICAL STUDY ON THE MIXING OF UNSORTED SEDIMENT PARTICLES DISCHARGED INTO A CROSS-FLOW BY MULTIPHASE PARTICLE-IN-CELL (MP-PIC) METHOD

    Institute of Scientific and Technical Information of China (English)

    Jie GU; Chiwai LI; Hong YANG; Yong ZHAN

    2007-01-01

    The mixing characteristics of dredged sediments of variable size discharged into cross-flow are studied by an Eulerian-Lagrangian method. A three-dimensional (3D) numerical model has been developed by using the modified k-ε parameterization for the turbulence in fluid phase/water and a Lagrangian method for the solid phase/sediments. In the model the wake turbulence induced by sediments has been included as additional source and sink terms in the k-ε model; and the trajectories of the sediments are tracked by the Lagrangian method in which the sediment drift velocities in cross-flow are computed by a multiphase particle-in-cell (MP-PIC) method and the diffusion process is approximated by a random walk model. The hydrodynamic behavior of dumped sediment cloud is governed by the total buoyancy on the cloud, the drag force on each particle and velocity of cross-flow. The cross-flow destroys more or less the double vortices occurred in stagnant ambience and dominates the longitudinal movement of sediment cloud. The computed results suggest satisfactory agreement by comparison with the experimental results of laboratory.

  20. 3D PIC Simulation of the Magnetosphere during IMF Rotation from North to South: Signatures of Substorm Triggering in the Magnetotail

    Science.gov (United States)

    Nishikawa, Ken-Ichi; Cao. D/ S/; Lembege, B.

    2008-01-01

    Three dimensional PIC simulations are performed in order to analyse the dynamics of the magnetotail as the interplanetary magnetic field (IMF) rotates from northward to southward direction. This dynamics reveals to be quite different within meridian/equatorial planes over two successive phases of this rotation. First, as IMF rotates from North to Dawn-Dusk direction, the X-Point (magnetic reconnection) evidenced in the magnetotail (meridian plane) is moving earthward (from x=-35 Re to x=-17.5 ) distance at which it stabilizes. This motion is coupled with the formation of "Crosstail-S" patterns (within the plane perpendicular to the Sun-Earth mine) through the neutral sheet in the nearby magnetotail. Second, as IMF rotates from dawn-dusk to South, the minimum B field region is expanding within the equatorial plane and forms a ring. This two-steps dynamics is analyzed in strong association with the cross field magnetotail current Jy, in order to recover the signatures of substorms triggering.

  1. Fluid-rock interactions related to metamorphic reducing fluid flow in meta-sediments: example of the Pic-de-Port-Vieux thrust (Pyrenees, Spain)

    Science.gov (United States)

    Trincal, Vincent; Buatier, Martine; Charpentier, Delphine; Lacroix, Brice; Lanari, Pierre; Labaume, Pierre; Lahfid, Abdeltif; Vennemann, Torsten

    2017-09-01

    In orogens, shortening is mainly accommodated by thrusts, which constitute preferential zones for fluid-rock interactions. Fluid flow, mass transfer, and mineralogical reactions taking place along thrusts have been intensely investigated, especially in sedimentary basins for petroleum and uranium research. This study combines petrological investigations, mineralogical quantifications, and geochemical characterizations with a wide range of analytical tools with the aim of defining the fluid properties (nature, origin, temperature, and redox) and fluid-host rock interactions (mass transfers, recrystallization mechanisms, and newly formed synkinematic mineralization) in the Pic-de-Port-Vieux thrust fault zone (Pyrenees, Spain). We demonstrate that two geochemically contrasted rocks have been transformed by fluid flow under low-grade metamorphism conditions during thrusting. The hanging-wall Triassic red pelite was locally bleached, while the footwall Cretaceous dolomitic limestone was mylonitized. The results suggest that thrusting was accompanied by a dynamic calcite recrystallization in the dolomitic limestone as well as by leaching of iron via destabilization of iron oxides and phyllosilicate crystallization in the pelite. Geochemical and physical changes highlighted in this study have strong implications on the understanding of the thrust behavior (tectonic and hydraulic), and improve our knowledge of fluid-rock interactions in open fluid systems in the crust.

  2. Anti-amnesic effect of alkaloid fraction from Lycopodiella cernua (L.) Pic. Serm. on scopolamine-induced memory impairment in mice.

    Science.gov (United States)

    Chuong, Nguyen Ngoc; Trung, Bui Huu; Luan, Tran Cong; Hung, Tran Manh; Dang, Nguyen Hai; Dat, Nguyen Tien

    2014-07-11

    Lycopodiella cernua (L.) Pic. Serm. (Licopodiaceae) has been used in Vietnamese folk medicine for treating central nervous system conditions. In this study, the alkaloid fraction from the methanol extract of this plant (VLC) was evaluated for in vitro acetylcholinesterase (AChE) inhibitory activity in cognition-relevant brain areas of mice. In in vivo study, the cognitive-enhancing effect of VLC on amnesic mice induced by scopolamine was investigated by assessing a passive avoidance and a Morris water maze test. VLC inhibited AChE activity in mouse frontal cortex, hippocampus and striatum with IC50 values of 26.7, 32.2 and 25.7μg/mL, respectively. Administration of VLC (10, 20, 50 and 100mg/kg, p.o.) significantly reversed cognitive impairments in mice by passive avoidance test. Treating with VLC (50mg/kg) reduced escape latencies in training trials and prolonged swimming times in the target quadrant during the probe trial in the water maze task (P<0.05). These results indicated that L. cernua originated from Vietnam has anti-cholinesterase activity and might be useful for the treatment of cognitive impairment.

  3. The New World Gibbobruchus Pic (Coleoptera, Chrysomelidae, Bruchinae): description of a new species and phylogenetic insights into the evolution of host associations and biogeography.

    Science.gov (United States)

    Manfio, Daiara; Jorge, Isaac R; Morse, Geoffrey E; Ribeiro-Costa, Cibele S

    2016-04-18

    The seed beetle Gibbobruchus tridentatus Manfio, Jorge & Ribeiro-Costa sp. nov. is described from the Amazon basin in Brazil (Acre) and Ecuador (Napo), and is included in an updated key to the species of Gibbobruchus Pic. This new species and the recently described G. bergamini Manfio & Ribeiro-Costa are incorporated into a phylogenetic reanalysis of the genus and into a comparative analysis of host plant use and biogeography. Species groups previously proposed were supported and the evolutionary history in host plant-use shows Gibbobruchus conserved at tribe level, Cercideae (Caesalpinioideae), with coordination between biogeographic expansion and host genus shifts. Both species, Gibbobruchus tridentatus Manfio, Jorge & Ribeiro-Costa sp. nov. and G. bergamini, were placed within the group scurra (G. tridentatus (G. scurra (G. cavillator+G. bolivianus+G. bergamini))) and supported by one synapomorphy. Additionally, we update geographic distributions and host plant records. Two hosts, Bauhinia argentinensis Burkart and B. tarapotensis Benth. are recorded for the first time as hosts for the genus and for the subfamily.

  4. 3D PIC Simulation of the Magnetosphere during IMF Rotation from North to South: Signatures of Substorm Triggering in the Magnetotail

    Science.gov (United States)

    Nishikawa, Ken-Ichi; Cao. D/ S/; Lembege, B.

    2008-01-01

    Three dimensional PIC simulations are performed in order to analyse the dynamics of the magnetotail as the interplanetary magnetic field (IMF) rotates from northward to southward direction. This dynamics reveals to be quite different within meridian/equatorial planes over two successive phases of this rotation. First, as IMF rotates from North to Dawn-Dusk direction, the X-Point (magnetic reconnection) evidenced in the magnetotail (meridian plane) is moving earthward (from x=-35 Re to x=-17.5 ) distance at which it stabilizes. This motion is coupled with the formation of "Crosstail-S" patterns (within the plane perpendicular to the Sun-Earth mine) through the neutral sheet in the nearby magnetotail. Second, as IMF rotates from dawn-dusk to South, the minimum B field region is expanding within the equatorial plane and forms a ring. This two-steps dynamics is analyzed in strong association with the cross field magnetotail current Jy, in order to recover the signatures of substorms triggering.

  5. Measurements and Monte Carlo simulations of the spectral variations of the cosmic-ray-induced neutrons at the Pic du Midi over a 2-y period.

    Science.gov (United States)

    Cheminet, A; Hubert, G; Lacoste, V; Boscher, D

    2014-10-01

    In this paper, a Bonner Sphere Spectrometer extended to high energies (HERMEIS) was employed to measure continuously the cosmic-ray-induced neutron spectra over a long-term period (2 y) at mountain altitude and medium geomagnetic latitude (Pic du Midi de Bigorre in the French Pyrenees, +2885 m, 5.6 GV). The results showed 1-y sinusoidal oscillations in the integrated fluence rates. The amplitude of these oscillations depends on the neutron energetic domain. The fluence rate of thermal neutrons was 53 % higher in August than that in February. Those of epithermal neutrons with energies between 0.4 eV and 0.1 MeV and evaporation neutrons (from 0.1 to 20 MeV) were ∼25 % higher in the summer than those in the winter. Finally, the cascade neutron fluence rate (>20 MeV) remained quite the same (<10 % variation). To understand the effects of local and seasonal changes in the measurement environment, GEANT4 simulations were performed. The nature of rock and thickness of the snow cover during the winter period (given by meteorological data) were investigated. A reasonable agreement between experiments and calculations was found.

  6. The hardware and software realization methods of SPI communication based on PIC16F73 and ADS8341%基于PIC16F73单片机和ADS8341的SPI通信软硬件实现方法

    Institute of Scientific and Technical Information of China (English)

    党瑞荣; 苗强

    2008-01-01

    文章介绍了PIC16F73单片机通过两种方式和模数转换器件ADS8341实现SPI通信,它们分别是软件实现和硬件实现.软件实现方法能很好的解决片内无SPI接口的PIE单片机与带有SPI接口的从机实现数据交换,而硬件方法能很方便地快速地实现带有SPI口的PIC单片机和带有SPI口的从机进行数据通信.

  7. 基于PIC18F248的RS232/CAN互连适配器的设计及实现%The Design and Realization of Interconnected Adapter Between RS232 and CAN Bus Based on PIC18F248 Microcomputer

    Institute of Scientific and Technical Information of China (English)

    陈彪; 毛六平; 戴瑜兴

    2004-01-01

    为了将变电站综合自动化系统中具有RS232接口的继电保护器接入到CAN通信网络中,设计了一种基于PIC18F248的RS232/CAN互连适配器,对其硬件接口电路、硬件抗干扰电路和CAN报文帧以及单片机软件流程的设计与实现进行了叙述.该互连适配器已成功应用于以RS232作为通信接口的继电保护器上,位速率高,通信稳定可靠,具有较强的抗干扰能力.

  8. 电子回旋共振放电的电离特性PIC/MCC模拟(Ⅰ)——物理模型与理论方法%The PIC/MCC simulation of the ionization processes in electron cyclotron resonance discharge ( Ⅰ )——Physical model and theoretical methods

    Institute of Scientific and Technical Information of China (English)

    金晓林; 杨中海

    2006-01-01

    采用粒子模拟与蒙特卡罗相结合(PIC/MCC)的方法对电子回旋共振(ECR)放电中的电离过程进行了模拟,其中带电粒子与微波的相互作用由PIC方法的电磁模型描述,粒子间的碰撞过程由MCC方法描述.考虑的碰撞类型有电子与中性粒子的弹性、激发、电离碰撞,离子与中性粒子的弹性、电荷交换碰撞,碰撞截面均依赖于能量而变化.阐述了理论分析的过程,为数值模拟ECR放电奠定了基础.

  9. Research and Manufacture of Intellectual Water Meters with IC Card Based on PIG16F84 Single-slice Computer%基于PIC16F84单片机的IC卡智能水表的研制

    Institute of Scientific and Technical Information of China (English)

    周鲜成

    2003-01-01

    本文提出了一种基于单片机PIC16F84的IC卡智能水表的设计方案.设计出系统硬件结构的主要组成部分电路;简述其基本工作原理;给出软件设计思想和主控程序软件框图.

  10. A three-dimensional particle-in-cell/Monte Carlo computer simulation based on negative hydrogen ion source%基于负氢离子源的全三维PIC/MCC模拟算法研究

    Institute of Scientific and Technical Information of China (English)

    杨超; 刘大刚; 王小敏; 刘腊群; 王学琼; 刘盛纲

    2012-01-01

    在分析负氢离子源中等离子体物理机理基础下,研究并优化粒子模拟算法,设计高效的粒子存储方法.研究并运用粒子碰撞蒙特卡罗方法,考虑等离子体势以及带电粒子间库仑碰撞,研制了全三维粒子模拟/蒙特卡罗算法(PIC/MCC).采用磁荷模型,运用时域有限差分方法计算多峰磁场,并结合国外负氢离子源JT-60U,考虑负氢离子源中主要反应,对全三维PIC/MCC模拟算法模拟验证.%Based on the analysis of the plasma physics mechanism in negative hydrogen ion source,the particle-in-cell algorithm is studied and optimized and a high efficient storage method of particles is designed.Using the Monte Carlo collision model,considering the plasma potential and coulomb collisions between charged particles,the full three-dimensional particle-in-cell/ Monte Carlo algorithm (PIC/MCC) is developed.With the magnetic charge model,using the FDTD method,the line cusp magnetic field is calculated.With the negative hydrogen ion source JT-60U and considering the main reactions in the negative hydrogen ion source,the full three-dimensional PIC/MCC simulation algorithm is verified by simulation.

  11. Bucolic Complexes

    CERN Document Server

    Brešar, Bostjan; Chepoi, Victor; Gologranc, Tanja; Osajda, Damian

    2012-01-01

    In this article, we introduce and investigate bucolic complexes, a common generalization of systolic complexes and of CAT(0) cubical complexes. This class of complexes is closed under Cartesian products and amalgamations over some convex subcomplexes. We study various approaches to bucolic complexes: from graph-theoretic and topological viewpoints, as well as from the point of view of geometric group theory. Bucolic complexes can be defined as locally-finite simply connected prism complexes satisfying some local combinatorial conditions. We show that bucolic complexes are contractible, and satisfy some nonpositive-curvature-like properties. In particular, we prove a version of the Cartan-Hadamard theorem, the fixed point theorem for finite group actions, and establish some results on groups acting geometrically on such complexes. We also characterize the 1-skeletons (which we call bucolic graphs) and the 2-skeletons of bucolic complexes. In particular, we prove that bucolic graphs are precisely retracts of Ca...

  12. Hybrid-PIC modeling of laser-plasma interactions and hot electron generation in gold hohlraum walls

    Science.gov (United States)

    Thoma, C.; Welch, D. R.; Clark, R. E.; Rose, D. V.; Golovkin, I. E.

    2017-06-01

    hohlraums should be stable to both two plasmon decay and stimulated Raman scattering instabilities for intensities ≤ 10 15 W/cm2. In gas-filled hohlraums, shocks may be induced in the blowoff gold plasma, which leads to more complex density and temperatures profiles. The resulting effect on LPI stability depends strongly on the details of the profile, and it is possible for the gas-filled hohlraum to become unstable to two plasmon decay at 1015 W/cm2 if the quarter-critical surface reaches temperatures exceeding 1 keV.

  13. Polyion complex micelles from plasmid DNA and poly(ethylene glycol)-poly(L-lysine) block copolymer as serum-tolerable polyplex system: physicochemical properties of micelles relevant to gene transfection efficiency.

    Science.gov (United States)

    Itaka, Keiji; Yamauchi, Kyosuke; Harada, Atsushi; Nakamura, Kozo; Kawaguchi, Hiroshi; Kataoka, Kazunori

    2003-11-01

    Polyion complex (PIC) micelles composed of the poly(ethylene glycol)-poly(L-lysine) (PEG-PLL) block copolymer and plasmid DNA (pDNA) were investigated in this study from a physicochemical viewpoint to get insight into the structural feature of the PIC micellar vector system to show practical gene transfection efficacy particularly under serum-containing medium. The residual ratio (r) of the lysine units in PEG-PLL to the phosphate units of pDNA in the system significantly affects the size of the PIC micelles evaluated from dynamic light scattering, being decreased from approximately 120 to 80 nm with an increase in the r value for the region with r > or = 1.0. The zeta potential of the complexes slightly increased with r in the same region, yet maintained a very small absolute value and leveled off to a few mV at r approximately 2.0. These results suggest that the micelles are most likely to take the core-shell structure with dense PEG palisades surrounding the PIC core to compartmentalize the condensed pDNA. Furthermore, an increasing r value in the region of r > or = 1 induces a rearrangement of the stoichiometric complex formed at r=1.0 to the non-stoichiometric complex composed of the excess block copolymer. The association number of pDNA and the block copolymer in the micelle was estimated from the apparent micellar molecular weight determined by static light scattering measurements, indicating that a single pDNA molecule was incorporated in each of the micelles prepared from the PEG (Mw=12,000 g/mol)-PLL (polymerization degree of PLL segment: 48) (12-48) block copolymer at r=2.0. These 12-48/pDNA micelles showed a gene expression comparable to the lipofection toward cultured 293 cells, though 100 microM chloroquine was required in the transfection medium. Notably, even in the presence of serum, the PIC micelles achieved appreciable cellular association to attain a high gene expression, which is in sharp contrast with the drastic decrease in the gene

  14. 基于PIC单片机的种子源设计%Design of seed source based on PIC microcontroller unit

    Institute of Scientific and Technical Information of China (English)

    张帆; 闫自让; 何鹏军; 荆晓鹏; 金兆鑫

    2012-01-01

    A capacitor-discharge seed source based on PIC has been designed. In order to charge quickly and effectively, the source takes advantage of the single-chip pulse width modulation(PWM) to produce a linear voltage which can control the DC-DC converter. And as a result, the charging process is constant current charging. Theoretical and experimental results show that, the seed soured charges fast, and reduces the loss during charging. Its energy storage is 250 J, and its volume is smaller than 3 000 cm5. The seed source, which can produce more than 2 kA initial current on 100 μH load in calculation, meets the test requirements.%对种子源结构进行了优化设计,为了缩短充电时间,在现有的电容和DC变换器基础之上,选用单片机作为控制芯片,利用其脉冲宽度调制(PWM)输出功能产生用于控制DC变换器的线性电压.对单片机PWM输出转化为线性控制电压的性能以及控制DC变换器恒流充电的可行性开展了实验研究.实验结果表明,基于PIC单片机的种子源储能可以达到250J,充电时间缩短到6 min以内,满足实验要求.

  15. Pt/PIC催化还原芳香硝基化合物制备芳胺%Pt/PIC catalyzed hydrogenation of aromatic nitro compounds to arylamine

    Institute of Scientific and Technical Information of China (English)

    张渊; 张瑞; 黄军; 朱福和

    2012-01-01

    制备了一种多孔离子型高聚物(简称离聚物PIC),利用扫描电镜、透射电镜等一系列手段对离聚物PIC的形貌、结构进行表征,并制备负载型纳米铂催化剂(Pt/PIC)用于温和条件下芳胺(如对苯二胺、邻苯二胺、2-溴苯胺等)的合成实验中。实验表明:在1 atm H2条件下,该Pt/PIC催化剂对于芳香硝基化合物还原氢化反应具有高的催化活性和选择性,尤其是还原性基团如醛基、酮基、氰基,在氢化还原相应硝基芳基化合物过程中未受影响,且高产率得到相应芳胺。%A porous ionic copolymer(PIC) was prepared and characterized by SEM,BET,and TEM.The morphology and structure was investigated.And a supported Pt nano-catalyst(Pt/PIC) was prepared and used for the synthesis of anilines(such as p-phenylenediamine,o-diaminobenzene,2-Bromoaniline,et al.) under mild conditions.The study results showed that Pt/PIC catalyst was highly active and selective for the hydrogenation of nitro aromatic compounds under 1 atm H2.Reducible groups such as aldehyde,ketone and nitrile were not attacked during the hydrogenation of the corresponding nitro compounds,and the corresponding anilines were obtained with high yield.

  16. Implementación del núcleo de un microcontrolador compatible con los PIC de la gama media en FPGA de Altera

    Directory of Open Access Journals (Sweden)

    Victor Escartín

    2010-09-01

    Full Text Available Normal 0 21 false false false ES-TRAD X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} En este trabajo se describe, el diseño del núcleo de un procesador compatible con el juego de instrucciones de microcontroladores PIC de la gama media. La estructura utilizada posee un pipeline de dos etapas. Se utiliza el lenguaje de descripción de hardware VHDL con dispositivos programables de las familias Cyclone de Altera. La metodología de diseño empleada es un proceso recurrente que se inicia con la definición de la arquitectura a nivel de bloques funcionales del sistema a diseñar, se realiza la modelación estructural y la implementación de cada bloque. Finalizando con la simulación funcional y temporal. Todo este proceso tiene como objetivo lograr un dispositivo con la mayor velocidad posible en su funcionamiento y sintetizarlo con el  menor número de celdas.

  17. Design of pH Measure Instrument Based on PIC Single-chip Microcomputer%基于PIC单片机的pH测试仪

    Institute of Scientific and Technical Information of China (English)

    曹顺; 李金凤; 魏立峰

    2012-01-01

    An acidity measure instrument was designed. The design principles,hardware circuit and software designs were introduced. The high-precision differential amplifier, INA116,amplified the weak voltage signal from the composite electrodes. The effects of field interference and high inner resistance of the composite electrodes were suppressed. In order to meet the measure accuracy, the temperature signal was compensated,and the electrode deviation was calibrated by software. The PIC single-chip)microcomputer processed the date real-timely. The instrument has the functions of two - point calibration, auto temperature compensation and historical data storage. The test results show that the instrument can measure the pH value of the solutions accurately ,Il meets the design requirements. The instrument has the advantages of high precision, good stability and convenient operation, and possesses broad application prospects.%设计了一种酸碱浓度(pH)测试仪,介绍了测量仪的设计原理、硬件电路及软件设计.选用高精度差动放大器INA116放大复合电极输出的微弱电压信号、抑制现场干扰及复合电极的高内阻影响.为满足测量精度,对温度信号进行了有效补偿并通过软件校正电极偏差.PIC单片机进行实时处理.测试仪具有两点标定、自动温度补偿等功能.测试结果表明:测试仪能准确地测量溶液的pH值,满足设计要求.具有精度高、稳定性好、操作便捷等优点,应用前景广阔.

  18. Influence of Triply-Charged Ions and Ionization Cross-Sections in a Hybrid-PIC Model of a Hall Thruster Discharge

    Science.gov (United States)

    Smith, Brandon D.; Boyd, Iain D.; Kamhawi, Hani

    2014-01-01

    The sensitivity of xenon ionization rates to collision cross-sections is studied within the framework of a hybrid-PIC model of a Hall thruster discharge. A revised curve fit based on the Drawin form is proposed and is shown to better reproduce the measured crosssections at high electron energies, with differences in the integrated rate coefficients being on the order of 10% for electron temperatures between 20 eV and 30 eV. The revised fit is implemented into HPHall and the updated model is used to simulate NASA's HiVHAc EDU2 Hall thruster at discharge voltages of 300, 400, and 500 V. For all three operating points, the revised cross-sections result in an increase in the predicted thrust and anode efficiency, reducing the error relative to experimental performance measurements. Electron temperature and ionization reaction rates are shown to follow the trends expected based on the integrated rate coefficients. The effects of triply-charged xenon are also assessed. The predicted thruster performance is found to have little or no dependence on the presence of triply-charged ions. The fraction of ion current carried by triply-charged ions is found to be on the order of 1% and increases slightly with increasing discharge voltage. The reaction rates for the 0?III, I?III, and II?III ionization reactions are found to be of similar order of magnitude and are about one order of magnitude smaller than the rate of 0?II ionization in the discharge channel.

  19. Communication complexity and information complexity

    Science.gov (United States)

    Pankratov, Denis

    Information complexity enables the use of information-theoretic tools in communication complexity theory. Prior to the results presented in this thesis, information complexity was mainly used for proving lower bounds and direct-sum theorems in the setting of communication complexity. We present three results that demonstrate new connections between information complexity and communication complexity. In the first contribution we thoroughly study the information complexity of the smallest nontrivial two-party function: the AND function. While computing the communication complexity of AND is trivial, computing its exact information complexity presents a major technical challenge. In overcoming this challenge, we reveal that information complexity gives rise to rich geometrical structures. Our analysis of information complexity relies on new analytic techniques and new characterizations of communication protocols. We also uncover a connection of information complexity to the theory of elliptic partial differential equations. Once we compute the exact information complexity of AND, we can compute exact communication complexity of several related functions on n-bit inputs with some additional technical work. Previous combinatorial and algebraic techniques could only prove bounds of the form theta( n). Interestingly, this level of precision is typical in the area of information theory, so our result demonstrates that this meta-property of precise bounds carries over to information complexity and in certain cases even to communication complexity. Our result does not only strengthen the lower bound on communication complexity of disjointness by making it more exact, but it also shows that information complexity provides the exact upper bound on communication complexity. In fact, this result is more general and applies to a whole class of communication problems. In the second contribution, we use self-reduction methods to prove strong lower bounds on the information

  20. Spectrophotometric study of the charge-transfer and ion-pair complexation of methamphetamine with some acceptors

    Science.gov (United States)

    Shahdousti, Parvin; Aghamohammadi, Mohammad; Alizadeh, Naader

    2008-04-01

    The charge-transfer (CT) complexes of methamphetamine (MPA) as a n-donor with several acceptors including bromocresolgreen (BCG), bromocresolpurple (BCP), chlorophenolred (CPR), picric acid (PIC), and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) have been studied spectrophotometrically in chloroform solutions in order to obtain some information about their stoichiometry and stability of complexation. The oscillator strengths, transition dipole moments and resonance energy of the complex in the ground state for all complexes have been calculated. Vertical ionization potential of MPA and electron affinity of acceptors were determined by ab initio calculation. The acceptors were also used to utilize a simple and sensitive extraction-spectrophotometric method for the determination of MPA. The method is based on the formation of 1:1 ion-pair association complexes of MPA with BCG, BCP and PIC in chloroform medium. Beer's plots were obeyed in a general concentration range of 0.24-22 μg ml -1 for the investigated drug with different acceptors. The proposed methods were applied successfully for the determination of MAP in pure and abuse drug with good accuracy and precision.