Robert Lepiksoni maailm / Eha Komissarov

Index Scriptorium Estoniae

Komissarov, Eha, 1947-

2000-01-01

Näitus "Minu maailm. Robert Lepikson fotograafina ja kollektsionäärina" galeriis "Vaal". Väljas on loodusfotod, fotod autodest, kunstikogust Eduard Steinbergi (1937) ja Vladimir Nemuhhini (1925) maalid, paar Salvador Dali värvilist litograafiat

Remembering Robert Seydel

Directory of Open Access Journals (Sweden)

Lauren van Haaften­-Schick

2011-06-01

Full Text Available This January, while preparing a new course, Robert Seydel was struck and killed by an unexpected heart attack. He was a critically under-appreciated artist and one of the most beloved and admired professors at Hampshire College.At the time of his passing, Seydel was on the brink of a major artistic and career milestone. His Book of Ruth was being prepared for publication by Siglio Press. His publisher describes the book as: “an alchemical assemblage that composes the life of his alter ego, Ruth Greisman— spinster, Sunday painter, and friend to Joseph Cornell and Marcel Duchamp. Through collages, drawings, and journal entries from Ruth’s imagined life, Seydel invokes her interior world in novelistic rhythms.”This convergence of his professional triumph with the tragedy of his death makes now a particularly appropriate time to think about Robert Seydel and his work. This feature contains a selection of excerpts from Book of Ruth (courtesy of Siglio Press alongside a pair of texts remembering him and giving critical and biographical insights into his art and his person. These texts, from a former student and a colleague respectively, were originally prepared for Seydel's memorial at Hampshire College and have since been revised for publication in continent.

Roberts 22: a bipolar nebula with OH emission

International Nuclear Information System (INIS)

Allen, D.A.; Hyland, A.R.; Caswell, J.L.

1980-01-01

Roberts 22 is a bipolar reflection nebula illuminated by a hidden A2 Ie star. Most of its energy is radiated at infrared wavelengths. It also shows strong OH maser emission (OH 284.18 - 0.79) on the 1612 and 1665 MHz transitions, generally similar to the masers associated with M stars having infrared excesses. But the system contains no late-type star. This remarkable assemblage of attributes makes Roberts 22 unique; however, it is probably a key member of the newly-recognized population of bipolar nebulae. From an analysis of the properties of Roberts 22 some published interpretations of other bipolar nebulae are questioned, in particular the derivation of spectral types for their underlying stars by the assumption of photo-ionization of the gas, and their evolutionary description as proto-planetary nebulae. (author)

Ross, Robert. – A Concise History of South Africa. Cambridge, Cambridge University Press, 1999, 219 p., index, bibl. (« Cambridge Concise Histories »).

OpenAIRE

Creusat, Laurence

2003-01-01

Robert Ross, maître de conférence à l'université de Leiden, écrit et publie depuis vingt ans des ouvrages sur l'histoire de l'Afrique du Sud. Son dernier livre qui prend comme point de départ l'introduction de l'agriculture dans ce pays, il y a de cela 1 500 ans, et le conclut avec l'arrivée à la présidence de N. Mandela, est un bel exemple d'étude synthétique réussie sur l'histoire de ce pays. Le mérite de ce livre est de montrer clairement comment le passé explique le présent, commen...

Magnetohydrodynamics and the earth's core selected works by Paul Roberts

CERN Document Server

Soward, Andrew M

2003-01-01

Paul Roberts'' research contributions are remarkable in their diversity, depth and international appeal. Papers from the Paul Roberts'' Anniversary meeting at the University of Exeter are presented in this volume. Topics include geomagnetism and dynamos, fluid mechanics and MHD, superfluidity, mixed phase regions, mean field electrodynamics and the Earth''s inner core. An incisive commentary of the papers puts the work of Paul Roberts into historical context. Magnetohydrodynamics and the Earth''s Core provides a valuable source of reference for graduates and researchers working in this area of geoscience.

[Roberts-SC phocomelia syndrome].

Science.gov (United States)

Musfeld, D A; Bühler, E M; Heinzl, S

2001-01-01

The Roberts-SC phocomelia syndrome is a rare autosomal recessive inherited disorder clinically manifested by tetraphocomelia, pre- and postnatal growth retardation, and craniofacial abnormalities (skull, eyes, lip, and palate), accompanied at times by centromer puffing and splitting, renal abnormalities, heart defect, clitoral or penile enlargement, and bilateral corneal opacities. Mental retardation is common in surviving patients.

Perspectivas historiográficas de las prácticas de lectura

Directory of Open Access Journals (Sweden)

Luis Ernesto Pardo Rodríguez

2011-08-01

Full Text Available Con el propósito de identificar elementos teóricos que orienten una descripción conceptual e histórica de las prácticas de lectura, el artículo recoge las voces de autores que, a su vez lectores, narran y describen sus propias historias de lectura: Alberto Manguel, Roger Chartier, Michel de Certeau, Ana Teberosky y Guglielmo Cavallo (prácticas de lectura y la lectura; Robert Darnton, Peter Burke y Renán Silva (fundamentos históricos e historiográficos; Giovanni Papini, Carl Sagan y Marcel Proust (los espacios e historias sobre prácticas de lectura. Con base en ello se adoptan tres perspectivas: la primera habla de un acercamiento a la lectura silenciosa como un hito en la transformación del aprendizaje y de los procesos cognitivos y de la intimidad en la práctica de lectura; la segunda, el impacto de la imprenta en las prácticas de lectura, una invención mecánica que generaliza el uso del papel en la impresión de textos y revoluciona las condiciones sociales, políticas y religiosas de la época, el acceso a la información, la transformación de los formatos de impresión y la producción y divulgación del conocimiento; y finalmente, un acercamiento conceptual a las prácticas de lectura, los abordajes investigativos desde el concepto de práctica y una aproximación histórica a las prácticas de lectura.

Skarp og præcis bog om præstationsløn

DEFF Research Database (Denmark)

Bukh, Per Nikolaj

2010-01-01

Anmeldelse af Rewarding Performance: Guiding principles, custom strategies, Robert J. Greene, Routledge......Anmeldelse af Rewarding Performance: Guiding principles, custom strategies, Robert J. Greene, Routledge...

Max Weber and Robert Michels.

Science.gov (United States)

Scaff, Lawrence A.

1981-01-01

This paper investigates the unique intellectual partnership of Max Weber and Robert Michels, with particular emphasis on Weber's influence on Michel's inquiry into the sociology of parties and organization. Concludes with an evaluation of the import of Weber's critique of Michels' work. (DB)

Steven Hawking with Robert Aymar

CERN Multimedia

Maximilien Brice

2006-01-01

Steven Hawking is seen meeting with CERN's Director-General, Robert Aymar. Hawking visited CERN between 24 September and 1 October 2006. During his stay he gave two lectures and toured the LHC, which may provide insights into Hawking's most famous area of study, black holes.

Anthony ROBERTS 5 March 1948 – 16 January 2008

CERN Multimedia

TS Department

2008-01-01

We deeply regret to announce the death of Mr Anthony ROBERTS on 16 January 2008. Mr ROBERTS, born on 05.03.1948, worked in the HR Department and had been employed at CERN since 01.06.1973. The Director-General has sent his family a message of condolence on behalf of the CERN staff. Social Affairs Service Human Resources Department

The inauguration of Robert-Bourassa Park at James Bay

International Nuclear Information System (INIS)

Valiquette, M.

1997-01-01

Robert Bourassa's contributions to the hydroelectric development at James Bay were acknowledged with the inauguration of a park in the ex-prime minister's name. Phase 1 of the James Bay hydroelectric project constituted the world's biggest construction site, employing more than 180,000 people from beginning to project completion. The James Bay project allowed Hydro-Quebec to gain one of the world's largest electric power utilities and to gain significant competitive edge over its competitors. The Robert Bourassa Park contains a picnic area and a visitor interpretation centre which describes the history of the project. A sequence of 5 signposts summarize the contributions that Robert Bourassa made to the megaproject which cost over $20.6 billion. The complex consists of 65 turbines which produce 15,235 megawatts of electricity. 1 fig

Conferencias a la Memoria de la Dra. Lydia J. Roberts 1967, 1969-1973 (Conferences in Memory of Dr. Lydia J. Roberts 1967, 1969-1973).

Science.gov (United States)

Puerto Rico Univ., Rio Piedras.

This publication includes eleven lectures presented as part of a conference given honoring Dr. Lydia J. Roberts. Seven of the papers are written in the English language and four in Spanish. Most of the papers relate to the topic of nutrition, but a few pay tribute to Dr. Roberts in recognition of her distinguished leadership and teacher of human…

Robert Wilson's Invitation to Insanity.

Science.gov (United States)

Stephens, Judith L.

The plays of stage director Robert Wilson are devices presenting alternative modes of perception to theatre audiences accustomed to verbal/aural structures of experience. Uniting his interests in the arts and therapy, his plays create a theatrical event promoting empathy with the perceptions of the mentally or physically handicapped and…

Double trisomy (48,XXX,+18) with features of Roberts syndrome

Energy Technology Data Exchange (ETDEWEB)

Descartes, M.; Longshore, J.W.; Crawford, E. [Univ. of Alabama, Birmingham, AL (United States)] [and others

1994-09-01

We report an infant with double trisomy 48,XXX,+18, who also displayed features of Roberts syndrome. All previously published cases with similar double trisomy have presented with features of trisomy 18 syndrome. The chromosome analysis done at birth revealed the double trisomy; parental chromosomes were normal. The proband presented with microbrachycephaly, unilateral cleft lip and palate, choanal atresia, midfacial capillary hemanioma, thin nares, shallow orbits, malformed ears, sparse hair, hypomelia of the upper limbs, rocker-bottom feet, auricular septal defect and agenesis of the corpus callosum. Characteristic features of Roberts syndrome included hypomelia, midfacial defects, and severe growth deficiency. Among the many different features reported in the literature for patients with trisomy 18 syndrome, the most consistent were growth deficiency, clenched fingers and congenital heart defects (e.g. VSD, ASD, PDA). Although some of our patient`s features such as cleft lip and cleft palate, low-set malformed ears, ASD, defects of the corpus callosum, choanal atresia, radial aplasia could also be seen in trisomy 18 syndrome (in 10-50% of the cases), her phenotype was more typical of Roberts syndrome because of symmetrical hypomelia and midfacial defects. Our patient`s chromosomes did not show premature separation of centromeric heterochromatin, a feature reported to occur in approximately one-half of individuals with Roberts syndrome. Sporadic aneuploidy involving different chromosomes has been found in lymphocyte cultures from some Roberts syndrome patients and is considered by some authors as a mitotic mutant. This aneuploidy is most likely to be chromosome gain. The simultaneous occurrence of trisomy X and 18 is extremely rare with only 11 cases having been reported in the literature. Our patient is unique since she has the double trisomy in addition to the characteristic features of Roberts syndrome.

Robert Nemiroff: Communicating Astronomy 365 Days a Year

Science.gov (United States)

Pullen, L.; Russo, P.

2010-06-01

Few astronomy communication projects are as well known or as widely disseminated as the Astronomy Picture of the Day (or APOD for short). Since its creation in 1995, it has popularised thousands of images and helped to explain the cosmos through informative captions. Impressively, the site shows no signs of slowing down and has amassed many loyal supporters. This success can be attributed to the two astronomers behind the project: Robert Nemiroff and Jerry Bonnell. CAPjournal has interviewed Robert to discover his view of APOD, and the lesser known issues that surround it.

The Timeless Legacy of Robert Koch

Indian Academy of Sciences (India)

Robert Koch was a German physician and scientist who made wide-ranging .... methods of bacterial staining so that bacteria could be visualized more easily and .... of whom became outstanding scientists in their own right, such as Friedrich.

Leaving Libertarianism: : Social Ties in Robert Nozick's New Philosophy

OpenAIRE

Herbjørnsrud, Dag

2002-01-01

SUMMARY This thesis Leaving Libertarianism: Social Ties in Robert Nozick s New Philosophy challenges the general and most widespread portrayals of the American philosopher Robert Nozick (1938-2002) by studying the notion of social ties in his later philosophy. The point of departure is the present descriptions of Nozick s philosophy. Mostly these depictions are based upon three postulates: That Nozick is an extreme individualist, that the libertarian Anarchy, State, and Utopia (1...

Roberts syndrome: clinical and cytogenetic aspects

OpenAIRE

Mann, N P; Fitzsimmons, J; Fitzsimmons, E; Cooke, P

1982-01-01

Roberts syndrome is reported in two sibs of consanguineous parents. Both infants had severe tetraphocomelia, facial clefting, and other serious malformations. In addition they were found to have an unusual cytogenetic abnormality with distortion of the normal sister chromatid relationship in many chromosomes.

The Timeless Legacy of Robert Koch

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 11; Issue 9. The Timeless Legacy of Robert Koch - Founder of Medical Microbiology. Jaya S Tyagi. General Article Volume 11 Issue 9 September 2006 pp 20-28. Fulltext. Click here to view fulltext PDF. Permanent link:

Intrapartum diagnostic of Roberts syndrome - case presentation.

Science.gov (United States)

Socolov, Răzvan Vladimir; Andreescu, Nicoleta Ioana; Haliciu, Ana Maria; Gorduza, Eusebiu Vlad; Dumitrache, Florentin; Balan, Raluca Anca; Puiu, Maria; Dobrescu, Mihaela Amelia; Socolov, Demetra Gabriela

2015-01-01

Roberts syndrome is a rare disease, with multiple limb and skeletal abnormalities (called "pseudothalidomide disease"). There are only around 150 cases described in literature. We present a case of Roberts syndrome, diagnosed in moment of delivery, after a pregnancy without prenatal follow-up. The stillborn baby was naturally delivered by a 17-year-old primiparous woman at 38 weeks of amenorrhea. The pregnancy was not followed due to socioeconomic and family situation, and no prenatal ultrasound was performed. The male baby has 2650 g and presented several morphological abnormalities and tight double umbilical abdominal loop. The macroscopic evaluation showed: dolichocephaly, hypoplastic inferior maxilla with micrognathia, antimongoloid palpebral slant, pterygium colli, abnormal and lower implanted ears, superior limbs phocomelia, syndactyly at lower left limb and tetradactyly in all limbs, bilateral cryptorchidism, pancreatic aplasia. Roberts syndrome is a rare genetic disease with recessive autosomal transmission generated by mutations in ESCO2 gene, located on chromosome 8. The disease should be easy to diagnose by antenatal ultrasound examination, but in our case, the lack of prenatal follow-up determined the diagnostic at term. We believe consider this case is an argument towards introducing ultrasound-screening compulsory to all pregnancies. To identify a possible genetic mutation, further investigations of the parents are in progress, but classically the disease has a recessive autosomal transmission.

Robert Frost: Teacher "Earner, Learner, Yearner."

Science.gov (United States)

Vogel, Nancy Sue

An account of Robert Frost's teaching, along with an assessment of it, are presented. Material consulted includes Frost's published letters, prose, and poetry; Lawrance Thompson's authorized biography; Lesley Frost's "New Hampshire's Child: The Derry Journals of Lesley Frost;" and additional sources such as films and periodicals,…

The meanings of J. Robert Oppenheimer

CERN Document Server

Banco, Lindsey Michael

2016-01-01

He called the first atomic bomb “technically sweet,” yet as he watched its brilliant light explode over the New Mexico desert in 1945 in advance of the black horrors of Hiroshima and Nagasaki, he also thought of the line from the Hindu epic The Bhagavad Gita: “I am become Death, the destroyer of worlds.” Physicist J. Robert Oppenheimer, the scientific director of the Manhattan Project, the single most recognizable face of the atomic bomb, and a man whose name has become almost synonymous with Cold War American nuclear science, was and still is a conflicted, controversial figure who has come to represent an equally ambivalent technology. The Meanings of J. Robert Oppenheimer examines how he has been represented over the past seven decades in biographies, histories, fiction, comics, photographs, film, television, documentaries, theater, and museums. Lindsey Michael Banco gathers an unprecedented group of cultural texts and seeks to understand the multiple meanings Oppenheimer has held in American popul...

Kirjavahetus Kaarel Robert Pustaga / Karl Ast Rumor

Index Scriptorium Estoniae

Rumor, Karl, pseud., 1886-1971

2009-01-01

Kirjavahetus Rio de Janeiros elava Karl Ast Rumori ja New Yorgis elava Kaarel Robert Pusta vahel Eesti kongressi kokkukutsumise vajalikkuse, väliseesti ühingute ja nõukogude, ajakirjanduse ning üldise poliitilise olukorra teemadel

Lieutenant General Robert L. Bullard: Understanding Small and Large Conflicts

Science.gov (United States)

2012-12-06

Publishing, 1925). 11 Robert L. Bullard, American Soldiers Also Fought ( Garden City, NY: Longmens and Green, 1936). 12 Ibid., V. 13 Ibid., VI...2005, 41-45. 53 Robert L. Bullard, “Among the Savage Moros,” Metropolitan Magazine, vol. XXIV:III (June 1906), 264. 19 increased during his...59 Bullard, “Among the Savage Moros,” 264. 22 intuitively knew that if he was to assist a partner, help the deprived, or fight an adversary, he

Robert Putnam : miks peaksime naabritega rohkem rääkima? / Robert Putnam ; interv. Külli-Riin Tigasson

Index Scriptorium Estoniae

Putnam, Robert

2006-01-01

26. mail Tallinnas toimuva Avatud Ühiskonna Foorumi peaesineja, Harvardi Ülikooli professor väidab, et mida paremini tuntakse oma naabreid, mida aktiivsemalt osaletakse kohalikus elus ning mida rohkem inimesed omavahel suhtlevad, seda paremaks ja turvalisemaks muutub nende elukeskkond. Lisad: Robert Putnam (sünd 1941); Kuidas kasvatada sotsiaalset kapitali?

“Trickster” and “Republican”: Robert Harley’s Political Career in the 1690s

Directory of Open Access Journals (Sweden)

Kiselev Aleksandr

2014-12-01

Full Text Available Despite the fact that Robert Harley is known as Tory politician, he began his career as a Whig politician. His grandfather and father were Presbyterians, and Robert Harley himself was a Presbyterian during his entire life. Harley’s family supported the Glorious Revolution of 1688. In 1689 Robert Harley was first elected to the House of Commons as a representative of the Whig party. Thanks to his wife’s Foley family, Robert Harley was elected as a commissioner of public accounts in the House of Commons. In 1689 Britain entered the “war of King William” which was a burden for many gentry (Whigs or Tories. Robert Harley became famous in the parliament as a critic of the war and corruption in the army. In 1693 the Whig leaders headed the ministry and continued the war. Their policy divided the Whigs party in two factions: “Court Whigs” and “Country Whigs”. Robert Harley and his supporters became “Country Whigs”, and they criticized the “Court Whigs”. By 1700 Robert Harley joined the Tory party. The article also describes the evolution of historiography of Harley‘s policy. Victorian historians have called the Prime Minister a “stupid person”. The same opinion was repeated by Russian historians of the 19th century. But in the 20th century the assessment of Robert Harley’s activity was changed by the works of K. Feiling, G. Holmes, B.W. Hill and other historians. Soviet historians (for example M.A. Barg also called R.Harley a “mediocre politician”, but modern Russian historians (L.I. Ivonina, T.L. Labutina and others consider him a “clever statesman” and a “master of political intrigues and parliamentary diplomacy”.

Cytogenetic diagnosis of Roberts SC phocomelia syndrome: First ...

African Journals Online (AJOL)

Tahir M. Malla

2015-07-14

/licenses/by-nc-nd/4.0/). 1. Introduction. Roberts SC phocomelia syndrome is an autosomal recessive developmental disorder characterized by pre and postnatal growth retardation, microcephaly, craniofacial anomalies,.

Roberts-SC phocomelia syndrome.

Science.gov (United States)

Maheshwari, A; Kumar, P; Dutta, S; Narang, A

2001-06-01

A severely growth retarded baby was born at 38 weeks gestation. He had multiple craniofacial anomalies, microbrachycephaly, phocomelia in the upper limbs and renal cysts visible on ultrasound. He died of recurrent apneas. The autopsy showed left sided multicystic dysplastic kidney and absence of one testis. Cytogenetic studies did not reveal any abnormality. The phenotypic features match those described in the Roberts-SC phocomelia syndrome. A literature review revealed that 50% of these patients have chromosomal defects and antenatal detection is possible on ultrasound and by chromosome analysis of the amniocytes.

Embracing the Humanistic Vision: Recurrent Themes in Peter Roberts' Recent Writings

Science.gov (United States)

Reveley, James

2018-01-01

Running like a leitmotif through Peter Roberts' recently published philosophico-educational writings there is a humanistic thread, which this article picks out. In order to ascertain the quality of this humanism, Roberts is positioned in relation to a pair of extant humanisms: radical and integral. Points of comparability and contrast are…

Two autographs: Cecile Dewitt and Robert Hawking (for Steven Hawking)

Science.gov (United States)

Gaina, Alex

2007-12-01

Two autographs given to author by professor Cecile Dewitt and Robert Hawking (the son of Steven Hawking for his father) in 1987 during the Quantum Gravity Seminar in Moscow are presented. The first was given during a visit to Physical Institute of the Academy of sciences of the USSR, where a seminar held in the Theoretical department. the second was given during a lunch with Steven Hawking, Andrei Linde and Robert Hawking at the 2-nd floor of the Conference floor.

Robert Knox, transcendentální anatomie a imaginace rasové války / Robert Knox, transcendental anatomy and imagination of racial war

Directory of Open Access Journals (Sweden)

Ivo Budil

2016-12-01

Full Text Available The main aim of the study is to emphasize the role and contribution of the Scottish physician and surgeon Robert Knox to the emergence and expansion of modern racial thinking and the concept of a racial war which became later influential as a result of the works of representatives of Social Darwinism. The main ideas outlined in the book The Races of Men: A Philosophical Enquiry into the Influence of Race over the Destinies of Nations, published by Robert Knox in 1850, will be analyzed in the historical and intellectual context of transcendental anatomy and Eurasian revolution.

Cytogenetic diagnosis of Roberts SC phocomelia syndrome: First report from Kashmir

Directory of Open Access Journals (Sweden)

Tahir M. Malla

2016-01-01

Full Text Available There are several syndromes in which specific mitotic chromosomal abnormalities can be seen, like premature centromere separation, premature (sister chromatid separation, and somatic aneuploidies. Identifications of such specific cytogenetic findings can be the key factor that leads towards the diagnosis of syndromes like Roberts SC phocomelia. The case presented here as Roberts SC phocomelia syndrome was identified as a child with multiple congenital anomalies and dysmorphic features. Conventional cytogenetic analysis of the case revealed premature sister chromatid separation. The premature centromeric separation was also confirmed by C banding analysis of the child. It is the first and the only case of Roberts SC phocomelia diagnosed from this part of the world. The present case report emphasizes the importance of conventional cytogenetics in the diagnosis of such syndromes.

THANK GOD FOR BOBBY: ROBERT KENNEDY AND THE CUBAN MISSILE CRISIS

Science.gov (United States)

2017-06-01

nomination and later confirmation of Robert Kennedy as United States Attorney General. The second was the failure of the Bay of Pigs operation in...Cuba. In nominating his brother, the President defied popular opinion and made a decision that would prove integral to his presidency. Although...and in place prior to the discovery of Soviet missiles in Cuba. Together, these two events gave Robert Kennedy a position from which to advise

Cytogenetic diagnosis of Roberts SC phocomelia syndrome: First report from Kashmir

OpenAIRE

Tahir M. Malla; Arshad A. Pandith; Fayaz A. Dar; Mahrukh H. Zargar

2016-01-01

There are several syndromes in which specific mitotic chromosomal abnormalities can be seen, like premature centromere separation, premature (sister) chromatid separation, and somatic aneuploidies. Identifications of such specific cytogenetic findings can be the key factor that leads towards the diagnosis of syndromes like Roberts SC phocomelia. The case presented here as Roberts SC phocomelia syndrome was identified as a child with multiple congenital anomalies and dysmorphic features. Conve...

Roberts-SC syndrome, a rare syndrome and cleft palate repair

Directory of Open Access Journals (Sweden)

Murthy Jyotsna

2008-01-01

Full Text Available Roberts SC syndrome is a rare syndrome with only 17 previously recognized patients reported in medical literature. The syndrome is characterized by multiple malformations, particularly, symmetrical limb reduction, craniofacial anomalies such as bilateral cleft lip and palate, micrognathia, and severe growth and mental retardation. Our patient, a young child of five years having Roberts-SC, was successfully operated for cleft palate under general anesthesia. The main features of the syndrome and the technical problems of anesthesia and surgery are discussed in this report.

American Prometheus. The Triumph and Tragedy of J. Robert Oppenheimer. Biography; J. Robert Oppenheimer. Die Biographie

Energy Technology Data Exchange (ETDEWEB)

Bird, Kai; Sherwin, Martin J.

2009-07-01

A definitive portrait of legendary scientist J. Robert Oppenheimer, the ''father'' of the atomic bomb, discusses his seminal role in the twentieth-century scientific world, as well as his lesser-known roles as family man, supposed communist, and head of Princeton's Institute for Advanced Studies. ''American Prometheus'' is a rich evocation of America in mid-century and a compelling portrait of scientist J. Robert Oppenheimer, a man shaped by its major events--the Depression, World War II, and the Cold War. (orig.) [German] J. Robert Oppenheimer (1904-1967), der ''Vater der Atombombe'', zaehlt zu den schillerndsten Figuren der juengeren Zeitgeschichte. Fuer ihre glaenzende Biographie des ''amerikanischen Prometheus'' erhielten der Journalist Kai Bird und der Historiker Martin J. Sherwin den Pulitzer-Preis. Exemplarisch lassen sie das Drama eines Forschers lebendig werden, der sich zwischen Erkenntnisdrang und ethischer Verantwortung entscheiden muss. Oppenheimer leitete das streng geheime Manhattan-Projekt in der Wueste von New Mexico, wo am 16. Juli 1945 die erste Atombombe gezuendet wurde. Kurz darauf starben in Hiroshima und Nagasaki mehr als 200 000 Menschen durch die neue ''Wunderwaffe'' - die Menschheit war ins Atomzeitalter eingetreten. Erschuettert von der Zerstoerungskraft seiner Schoepfung, engagierte sich Oppenheimer fortan gegen den Einsatz nuklearer Waffen. Das machte ihn im Amerika der McCarthy-Aera verdaechtig. Er geriet ins Visier des FBI, wurde als Spion der Sowjetunion verleumdet und musste den Staatsdienst quittieren. Sein Privatleben wurde an die Oeffentlichkeit gezerrt, seine Wohnung verwanzt, sein Telefon abgehoert. Erst 1963 rehabilitierte ihn Praesident Kennedy. Ueber dreissig Jahre hinweg haben die Autoren Interviews mit Oppenheimers Angehoerigen, Freunden und Kollegen gefuehrt, FBI-Akten gesichtet, Tonbaender von Reden und Verhoeren

Robert Aymar, Director-General of CERN

CERN Document Server

Patrice Loïez

2003-01-01

Robert Aymar, photographed in 2003 before taking his position as Director-General at CERN, succeeding Luciano Maiani in 2004. At this time, Aymar was director of the International Thermonuclear Experimental Reactor (ITER) although he had already been involved with developments at CERN, chairing the External Review Committee, set up in 2001 in response to the increased cost of the LHC.

Abstract – IT Robert Lepage: anatomia di un regista

Directory of Open Access Journals (Sweden)

Giulio Boato

2012-01-01

Full Text Available Abstract – ITRobert Lepage è uno dei registi più rilevanti del panorama teatrale internazionale contemporaneo. L’articolo cerca di fornire una sintetica analisi della poetica del regista soffermandosi in particolar modo sulle nozioni di “montaggio” e di “immagine” al fine di definire il rapporto tra tecnologia e linguaggio in teatro. L’analisi di due spettacoli di Lepage presentati in occasione del Napoli Teatro Festival Italia(edizioni 2010 e 2011 alimenta la riflessione teorica che si snoda seguendo una metafora anatomica:analizzare separatamente (sezionando come il chirurgo le varie componenti narrative e formali del modus operandi lepagiano permette di comprendere più agevolmente l’architettura organica dell’insieme Abstract – FR Robert Lepage est un des metteurs en scène les plus remarqués de la scène théâtrale internationale contemporaine. L’article cherche à fournir une analyse synthétique de l’art poétique du metteur en scèneen se concentrant en particulier sur les notions de « montage » et « image » afin d’en définir le rapportentre technologie et langage au théâtre. L’analyse de deux spectacles de Lepage présentés pendant leNapoli Teatro Festival Italia (éditions 2010 et 2011 alimente la réflexion théorique qui se développeselon une métaphore anatomique : à la manière d'un chirurgien disséquant un corps, on analyseraséparément les différentes composantes narratives et formelles utilisées par Lepage afin de comprendreplus facilement l’architecture organique de l’ensemble. Abstract – EN Robert Lepage is one of the most significant directors on the international and contemporary theatrescene. The article tries to provide a synthetic analysis of the director’s work: focusing on the notions of “editing” and “image”, it defines the relation between technology and language in theatre. The analysis oftwo pieces of theatre presented at the Napoli Teatro Festival Italia

PR-PR: cross-platform laboratory automation system.

Science.gov (United States)

Linshiz, Gregory; Stawski, Nina; Goyal, Garima; Bi, Changhao; Poust, Sean; Sharma, Monica; Mutalik, Vivek; Keasling, Jay D; Hillson, Nathan J

2014-08-15

To enable protocol standardization, sharing, and efficient implementation across laboratory automation platforms, we have further developed the PR-PR open-source high-level biology-friendly robot programming language as a cross-platform laboratory automation system. Beyond liquid-handling robotics, PR-PR now supports microfluidic and microscopy platforms, as well as protocol translation into human languages, such as English. While the same set of basic PR-PR commands and features are available for each supported platform, the underlying optimization and translation modules vary from platform to platform. Here, we describe these further developments to PR-PR, and demonstrate the experimental implementation and validation of PR-PR protocols for combinatorial modified Golden Gate DNA assembly across liquid-handling robotic, microfluidic, and manual platforms. To further test PR-PR cross-platform performance, we then implement and assess PR-PR protocols for Kunkel DNA mutagenesis and hierarchical Gibson DNA assembly for microfluidic and manual platforms.

Beck x Roberts: Comparativos do Diagrama do Metrô de Londres

Directory of Open Access Journals (Sweden)

Joaquim Redig

2015-06-01

Full Text Available Este artigo foi originalmente dirigido à disciplina Design e Visualização da Informação, ministrada pelo Prof. André Monat no curso de Doutorado em Design da ESDI-UERJ, Escola Superior de Desenho Industrial da Universidade do Estado do Rio de Janeiro, em 2013, a partir da proposta do professor de se examinar a pertinência da estrutura radial proposta por Maxwell J. Roberts para o design de mapas de redes de transporte. No artigo, procuro demonstrar que, por ser uma forma padrão pré-convencionada e abstrata, não valorizando a relação visual analógica com o objeto representado – a rede geo-espacial do sistema de transporte, variável para cada cidade – a estrutura radial não facilita a compreensão e o uso da rede, relativamente ao sistema ortogonal/diagonal projetado por Harry Beck para o assim chamado Diagrama do metrô londrino, que, partindo do código mais universal e ancestral de orientação que é a Rosa dos Ventos, se baseia nos eixos dos percursos. Por isso, este sistema se tornou um paradigma mundial no campo do Design de Informação, ainda não superado.

Numerical Methods in Atmospheric and Oceanic Modelling: The Andre J. Robert Memorial Volume

Science.gov (United States)

Rosmond, Tom

Most people, even including some in the scientific community, do not realize how much the weather forecasts they use to guide the activities of their daily lives depend on very complex mathematics and numerical methods that are the basis of modern numerical weather prediction (NWP). André Robert (1929-1993), to whom Numerical Methods in Atmospheric and Oceanic Modelling is dedicated, had a career that contributed greatly to the growth of NWP and the role that the atmospheric computer models of NWP play in our society. There are probably no NWP models running anywhere in the world today that do not use numerical methods introduced by Robert, and those of us who work with and use these models everyday are indebted to him.The first two chapters of the volume are chronicles of Robert's life and career. The first is a 1987 interview by Harold Ritchie, one of Robert's many proteges and colleagues at the Canadian Atmospheric Environment Service. The interview traces Robert's life from his birth in New York to French Canadian parents, to his emigration to Quebec at an early age, his education and early employment, and his rise in stature as one of the preeminent research meteorologists of our time. An amusing anecdote he relates is his impression of weather forecasts while he was considering his first job as a meteorologist in the early 1950s. A newspaper of the time placed the weather forecast and daily horoscope side by side, and Robert regarded each to have a similar scientific basis. Thankfully he soon realized there was a difference between the two, and his subsequent career certainly confirmed the distinction.

Robert Klopstock and Franz Kafka--the friends from Tatranské Matliare (the High Tatras).

Science.gov (United States)

Mydlík, M; Derzsiová, K

2007-01-01

The paper summarises the accessible literature on the life and work of well-known American lung surgeon, Professor Dr. Med. Robert Klopstock, who was in the years 1920-1924 a friend Franz Kafka. Professor Klopstock was of Hungarian origin and he got acquainted with Franz Kafka at the end of the year 1920 in Tatranské Matliare (The High Tatras). They were both patients treated for lung tuberculosis. They became close friends and their mutual correspondence shows their real friendship. Robert Klopstock was present at Franz Kafka's death-bed on June 3, 1924 in Kierling, near Klosterneuburg, not far from Vienna. Robert Klopstock studied at Medical Faculties of the Universities in Budapest, Prague, Kiel and Berlin. After his graduation in 1933 in Berlin, he worked as a lung surgeon at various surgical clinics and departments in Budapest and Berlin. In 1936 Robert Klopstock together with his wife visited the High Tatras and Tatranské Matliare. In 1937 Robert Klopstock with his wife Gizela, a writer and a translator, who translated the first chapters of Franz Kafka's novel "Trial" into Hungarian language, went to United States of America. During his stay in U.S.A. Dr. Med. Robert Klopstock was very active as a lung surgeon and a scientist. He published 64 specialized scientific papers, mostly in American medical journals. He became Professor of Lung Surgery at Downstate Medical Centre in New York-Brooklyn. He died on June 15, 1972 in New York.

Robert Aymar receives one of the highest Finnish distinctions

CERN Multimedia

2008-01-01

On 9 December 2008 Robert Aymar, CERN Director-General, was awarded the decoration of Commander, first class, of the Order of the Lion of Finland by the President of the Republic of Finland. This decoration, one of the highest of Finland, was presented in a ceremony by the Ambassador Hannu Himanen, Permanent Representative of Finland to the UN and other international organisations in Geneva. Robert Aymar was honoured for his service to CERN, the LHC, his role in the cooperation between Finland and CERN, as well as his contribution to science in general. In his speech the ambassador underlined CERN’s efforts in the field of education, mentioning the High school teachers programme.

Robert Eisenstein joins the ATLAS collaboration at CERN

CERN Multimedia

Maximilien Brice

2002-01-01

Robert Eisenstein, former assistant director for mathematical and physical sciences (MPS) at the US National Science Foundation (NSF), has stepped down from the job to spend a year at CERN as a member of the ATLAS collaboration.

Intervjuu American Wind Symphony Orchestra dirigendi Robert Austin Boudreau'ga = Interview with Mr. Robert Austin Boudreau, director of the American Wind Symphony Orchestra / Robert Austin Boudreau ; interv. Heli Ojamaa

Index Scriptorium Estoniae

Boudreau, Robert Austin

2007-01-01

11. IV 2007. a. tehtud telefoniintervjuu Robert A. Boudreau'ga, kellele arhitekt Louis I. Kahn disainis kontserdilaevad Point Counterpoint I (valmis 1961) ja Point Counterppoint II (kavandamist alustati 1966, valmis 1975). Louis I. Kahnist, koostööst arhitektiga ja laevadest. Selgitav kaaskiri arhitekt Heli Ojamaalt. Ill.: I laeva makett, II laeva joonised ja 4 värv. fotot

Robert Henry Thurston: Professionalism and Engineering Education

Science.gov (United States)

Nienkamp, Paul

2016-01-01

Robert Henry Thurston is presented in this article. He provides one the most significant examples of professionalizing engineering through innovative education and promoting scientific education practices in the late nineteenth century. The son of a draftsmen and steam engine mechanic, Thurston spent his early years in Providence, Rhode Island.…

La Corte Roberts e la questione della “preghiera municipale”

Directory of Open Access Journals (Sweden)

Adelaide Madera

2017-02-01

 The Roberts Court and the “municipal prayer” Abstract: In the USA, few topics are more divisive than the government’s use of religious expressions and symbols. The Supreme Court has tried to find a balance between the Establishment Clause of the U.S. Constitution and the inclusion of religious expressions in government activities. In Town of Greece v. Galloway, the Roberts Court upheld a town’s practice of opening board meetings with prayers from invited speakers. The essay critically examines the various opinions in the case, and looks at where this decision suggests the Establishment Clause doctrine is moving award.

American Prometheus. The Triumph and Tragedy of J. Robert Oppenheimer. Biography

International Nuclear Information System (INIS)

Bird, Kai; Sherwin, Martin J.

2009-01-01

A definitive portrait of legendary scientist J. Robert Oppenheimer, the ''father'' of the atomic bomb, discusses his seminal role in the twentieth-century scientific world, as well as his lesser-known roles as family man, supposed communist, and head of Princeton's Institute for Advanced Studies. ''American Prometheus'' is a rich evocation of America in mid-century and a compelling portrait of scientist J. Robert Oppenheimer, a man shaped by its major events--the Depression, World War II, and the Cold War. (orig.) [de

Robert Lawson (?1846-1896).

Science.gov (United States)

Larner, A J; Gardner-Thorpe, C

2012-04-01

Various descriptions of what would now be called Korsakoff Syndrome may be found in the medical literature predating the eponymous reports of Sergei Korsakoff (1854-1900) that date from 1887 onwards. Of these, it has been stated that the "most promising account" (Draaisma in Disturbances of the mind 163-164, 2009) may be that of Dr. Robert Lawson, published in 1878 in the journal Brain in its inaugural year of publication (Lawson in Brain 1:182-194, 1878). As Lawson is likely to be an unfamiliar name to most neurologists, and does not appear in the Oxford Dictionary of National Biography, we offer this brief account of his life and work.

75 FR 32740 - Action Affecting Export Privileges; Aaron Robert Henderson and Valhalla Tactical Supply

Science.gov (United States)

2010-06-09

... Robert Henderson and Valhalla Tactical Supply In the Matter of: Aaron Robert Henderson, 740 Jessie St., North Liberty, IA 52317. Respondent and Valhalla Tactical Supply, 740 Jessie Street, North Liberty, IA... is the owner, operator and president of Valhalla Tactical Supply (``Valhalla''), Valhalla is related...

Robert Rodrigueze verejugadega õudusfilm tuleb Igavuse planeedilt / Mihkel Raud

Index Scriptorium Estoniae

Raud, Mihkel, 1969-

2007-01-01

Filmiprojekt "Grindhouse" koosneb Robert Rodrigueze retroõudukast "Grindhouse : Õuduste planeet" ("Planet Terror") ja Quentin Tarantino 70-ndatest inspireeritud õudusfilmist "Surmakindel" ("Death Proof") : Ameerika Ühendriigid 2007. R. Rodrigueze filmist

Astronaut Robert L. Crippen prepares for underwater training session

Science.gov (United States)

1983-01-01

Astronaut Robert L. Crippen, STS-7 crew commander, adjusts his extravehicular mobility unit's (EMU) gloves prior to donning his helmet for a training session in the weightless environment test facility (WETF).

Das Fortbildungsangebot der Bibliothek des Robert Koch-Instituts: Dienstleistung im Publikationsprozess

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Senst, Henriette

2013-12-01

Full Text Available [english] Robert Koch-Institute’s scientists are supported during the publishing process in different ways. Relating to frequently asked questions the library offers trainings, which are integrated in the training program of the institute.How does a good literature research work? How do I manage my literature and how do I cite correctly? What do I have to consider during the publishing process? These and other questions are answered in trainings on literature research, managing bibliographies with EndNote and “Scientific Publishing in the Robert Koch-Institute” which take place regularly.

Expanding the mutation and clinical spectrum of Roberts syndrome.

Science.gov (United States)

Afifi, Hanan H; Abdel-Salam, Ghada M H; Eid, Maha M; Tosson, Angie M S; Shousha, Wafaa Gh; Abdel Azeem, Amira A; Farag, Mona K; Mehrez, Mennat I; Gaber, Khaled R

2016-07-01

Roberts syndrome and SC phocomelia syndrome are rare autosomal recessive genetic disorders representing the extremes of the spectrum of severity of the same condition, caused by mutations in ESCO2 gene. We report three new patients with Roberts syndrome from three unrelated consanguineous Egyptian families. All patients presented with growth retardation, mesomelic shortening of the limbs more in the upper than in the lower limbs and microcephaly. Patients were subjected to clinical, cytogenetic and radiologic examinations. Cytogenetic analysis showed the characteristic premature separation of centromeres and puffing of heterochromatic regions. Further, sequencing of the ESCO2 gene identified a novel mutation c.244_245dupCT (p.T83Pfs*20) in one family besides two previously reported mutations c.760_761insA (p.T254Nfs*27) and c.764_765delTT (p.F255Cfs*25). All mutations were in homozygous state, in exon 3. The severity of the mesomelic shortening of the limbs and craniofacial anomalies showed variability among patients. Interestingly, patient 1 had abnormal skin hypopigmentation. Serial fetal ultrasound examinations and measurements of long bones diagnosed two affected fetuses in two of the studied families. A literature review and case comparison was performed. In conclusion, we report a novel ESCO2 mutation and expand the clinical spectrum of Roberts syndrome. © 2015 Japanese Teratology Society.

Aitab hädaldamisest / Robert Antropov

Index Scriptorium Estoniae

Antropov, Robert, 1965-

2006-01-01

Endine politseijuht on seisukohal, et politseinike ja päästjate nappuses ei saa süüdistada ainult väikseid palku, küsimus on valikutes: kuidas ja millesse ressursse paigutada. Kalle Laanet ja Raivo Aeg vastavad küsimusele, mis on nende haldusalas konkreetselt kavas, et politsei saaks täita oma tegevusprioriteeti 100% ja tagada sisejulgeoleku. Vt. ka Robert Antropovi kommentaari 7. aug. Eesti Päevaleht lk. 2

Discovering Moral Engagement: An Interview with Robert Coles.

Science.gov (United States)

Scott, Bradwell D.

1995-01-01

Educator Robert Coles argues that there is a need for a basis on which to teach and cultivate moral awareness in parents and children. Active parenting requires both inner-directed and outer-directed focuses to take advantage of the everyday events through which morality is developed. (SLD)

Transitioning Natures: Robert Schuller’s Garden Grove Experiment

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Antonio Petrov

2016-09-01

Full Text Available Through the lens of Evangelist Reverend Robert H. Schuller’s Garden Grove drive-in walk-in church, this paper aims to exemplify how his architecture has transcended existing geographies that have long been anchored by the epistemology of what can be referred to as traditional “religious” architecture. This paper examines how Schuller instrumentalized broader imbrications of political contexts to change or manipulate the traditional religious subject. It also presents how Robert Schuller’s Garden Grove experiment reconceptualized “territory” as an evolving ideological dimension; not as a trajectory, or as transitory space, but as inhabitable third nature. My analysis challenges established readings of religious architecture as being interiorized manifestations. To do so, it poses the following questions: how does this meta-geographical dimension shed new light on questions of (traditional architectural aesthetics in Protestant architecture? What spaces and politics does it produce? Does the third nature have a history of its own?

Robert Sternberg's mental self-government theory and its ...

African Journals Online (AJOL)

Robert Sternberg's mental self-government theory and its contribution to our understanding of first-year distance learners' multiple thinking style preferences. ... This intelligence (the perception we have of information systems and the way we manage them) will influence the way we think and learn. This also applies to ...

Sir Robert Sidney’s Poems Revisited: the alternative sequence

OpenAIRE

Relvas, Maria de Jesus C.

1997-01-01

The essay approaches the lyric sequence written by Sir Robert Sidney (1563-1626) in the Elizabethan age, by mainly exploring its unique formal structure, which encloses an alternative sequence formed by a re-numbering of several poems.

Ravel and Robert-Houdin, Magicians

DEFF Research Database (Denmark)

Fillerup, Jessie

2013-01-01

,” which resonates with accounts of Ravel's Baudelairean artifice in life and work. For magicians, “illusion” was interchangeable with “effect.” The word “effect” recurs in both Ravel's writings and “The Philosophy of Composition,” a theoretical-didactic essay by Edgar Allan Poe, whom Ravel cited as one...... of his most important artistic influences. Ravel's appreciation of Poe has a much richer grain than has been imagined, extending beyond compositional artisanship to include literary and theatrical stratagems. Robert-Houdin, who started his career as a clockmaker, featured automata at his Soiréé...

Quality of life research: interview with Professor Robert Cummins

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Robert Cummins

2013-09-01

Full Text Available Health-related quality of life (HRQOL is a fundamental concept in the field of clinical medicine and has been studied during the last years by psychologists, sociologists, economists and managers. The concept of HRQOL includes those aspects of overall QOL that can be indicated to have an impact on patients’ health, either physical or psychological. Concerning the individuals, this incorporates physical and mental health cognitions, including sociodemographic factors, sexual functioning, fatigue, sleep disorders and functional status. One of the most eminent experts in the world in the field of QOL is Prof. Robert Cummins [Professor of Psychology at Deakin University in Australia (School of Psychology, Deakin University, 221 Burwood Highway, Victoria 3125 Melbourne, Australia. E-mail: robert.cummins@deakin.edu.au] who kindly accepted to answer our questions in the con- text of this special edition.

Robert Schuman, principal architect of the European Union

NARCIS (Netherlands)

Margriet Krijtenburg

2015-01-01

A tangible proof of the meaning and scope of human flourishing that can change not only organizations but also entire societies, is given by Robert Schuman, the French Minister of Foreign Affairs who launched the Schuman Declaration (1950) that gave birth to the EU. His leitmotiv was to be a

Research Ship Robert Gordon Sproul Underway Meteorological Data, Quality Controlled

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Research Ship Robert Gordon Sproul Underway Meteorological Data (delayed ~10 days for quality control) are from the Shipboard Automated Meteorological and...

Zombilood / Robert Kirkman ; intervjueerinud Margit Tõnson, Peeter Helme

Index Scriptorium Estoniae

Kirkman, Robert

2010-01-01

Režissöör George A. Romero kultusfilmid zombidest "Elavate surnute öö", "Surnute koidik", "Surnute päev" jpt. on inspiratsiooniks koomiksikirjutaja Robert Kirklandile. Režissöör Frank Darabont on teinud tema tuntuimast koomiksiseeriast "The Walking Dead" teleseriaali "Kõndivad surnud". Zombiteema kasvavast populaarsusest ning intervjuu koomiksikirjutajaga

Education and Utopia: Robert Owen and Charles Fourier

Science.gov (United States)

Leopold, David

2011-01-01

The aims of education, and the appropriate means of realising them, are a recurring preoccupation of utopian authors. The utopian socialists Robert Owen (1771-1858) and Charles Fourier (1772-1837) both place human nature at the core of their educational views, and both see education as central to their wider objective of social and political…

Unusually Gothic : Robert Sigl's Laurin (1987)

OpenAIRE

Stiglegger, Marcus

2010-01-01

Marcus Stiglegger revives a lost Gothic treasure in this brief discussion of Robert Sigl's Laurin—a rare case of German genre film-making and the heir to FW Murnau's legacy. Phantastic genre cinema is very rare in contemporary Germany—especially in the 1980s, the time when Italian horror reached another peak with Dario Argento's Opera (1985). The cliché of the German "easy comedy" ruled mainstream film production at the time, and so it appeared a kind of miracle when 27-year-old writer/direct...

Architecture of (impossibilities: Robert Smithson's expositive spaces

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Bráulio Romeiro

2012-06-01

Full Text Available This work investigates the North American artist Robert Smithson’s considerations on traditional expositive spaces: the museum and art gallery, as well as unusual and unexplored spaces by art up to that time. Looking through his texts we notice some enhanced perspectives and reset others, increasing limitation set on White Cube’s abstract and neutral quality and the substantiation on ideologies behind of these spaces manifestation.

Robert Hooke, 1635-1703.

Science.gov (United States)

Rowbury, Robin

2012-01-01

Robert Hooke was a polymath whose expertise during the 17th century spanned many different scientific areas. As a schoolboy on the Isle of Wight he was obsessed with the possibility of human flight and later became equally absorbed in cosmology and planetary motion. His skills as an artist were put to good use both as an architect following the Great Fire of London and before that in Micrographia. Although that book is best known for demonstrating the power of Hooke's microscope, Micrographia describes distant planetary bodies, the wave theory of light, the organic origin of fossils, and various other philosophical and scientific interests of its author The following thumbnail sketches of Hooke reveal him to be a man of enormous energy and imagination whose ideas were often pirated or under-rated.

Stylistic Analysis of Robert Browning's Poem "Patriot into Traitor

Science.gov (United States)

Ahmed, Mumtaz; Irshad, Ayesha

2015-01-01

The stylistic analysis of Robert Browning's poem "Patriot into Traitor" is done by using graphological, phonological, morphological and lexico-syntactic patterns. This analysis is helpful in decoding the underlying meanings of the poem. It clearly brings to surface what the poet really wants to impart.

The auriferous placer at Mount Robert, Pietersburg Greenstone belt

International Nuclear Information System (INIS)

Saager, R.; Muff, R.

1986-01-01

The Mount Robert gold placer near Potgietersrus occurs in coarse, matrix-supported conglomerates of the Uitkyk Formation within the Pietersburg greenstone belt. Sedimentological and mineralogical investigations indicate that the conglomerates and the ore minerals were derived from a greenstone provenance, and that they were deposited in a braided river environment within a rapidly subsiding trough. Lack of sedimentological concentration of the heavy minerals is considered to be the main reason for the low and erratic gold grades encountered (usually below 1 g/t) and, thus, the failure of all past mining ventures. The mineralogical composition of the Mount Robert ore closely resembles that of the Witwatersrand deposits. However, uraninite is absent, probably as a result of its complete removal by weathering processes. Remaining small uranium concentrations can still be detected within the conglomerates where they occur associated with grains of carbonaceous matter, leucoxene aggregates, and secondary iron-hydroxides. U3O8 values found in the conglomerates are given

TBT recommends : Vera Bila. The No Smoking Orchestra. Robert Plant

Index Scriptorium Estoniae

2005-01-01

Mustlasansambli Kale ja Vera Bila kontserdist 8. apr Tallinnas. Bosnia filmirežissööri Emir Kusturica ja tema ansambli No Smoking Orchestra kontserdist 12. apr. Riias. Inglise rocklaulja Robert Planti kontserdist 10. apr. Vilniuses

Kventin Tarantino + Robert Rodriges = Grainhaus, ili Kinonostalgija po-amerikanski / Andrei Sozinov

Index Scriptorium Estoniae

Sozinov, Andrei

2007-01-01

Filmiprojekt "Grindhouse" koosneb Robert Rodrigueze retroõudukast "Grindhouse : Õuduste planeet" ("Planet Terror") ja Quentin Tarantino 70-ndatest inspireeritud õudusfilmist "Surmakindel" ("Death Proof") : Ameerika Ühendriigid 2007

De 'wraak van de geografie' volgens Robert D. Kaplan

NARCIS (Netherlands)

Mamadouh, V.

2013-01-01

De Amerikaanse publicist Robert D. Kaplan heeft een nieuwe bestseller, De wraak van de geografie, waarin hij het belang van geografie voor de internationale politiek uit de doeken doet. Zijn roep om meer aandacht voor geografie is echter erg eenzijdig en een miskenning van alles waar ons vak voor

Antes de los Estudios Culturales. Robert Warshow y la experiencia

Directory of Open Access Journals (Sweden)

Antonio Lastra

2008-01-01

Full Text Available Este artículo estudia la influencia del concepto de experiencia que desarrolla Robert Warshow. Warshow ha supuesto el contrapunto americano a las teorías desarrolladas por Walter Benjamien en Europa. Si bien ambos insistieron en la pobreza de la experiencia, como resultado de la tecnificación de la sociedad, Warshow supo introducir matizaciones que influyeron en todo el círculo de intelectuales concentrados en Nueva York durante la etapa de consolidación de los Estudios Culturales. This paper studies the influence of the experience concept by Robert Warshow. Warshow is the American counterpoint to theories developed by Walter Benjamin in Europe. Although both insisted in the poverty of experience, as a result of technique, Warshow knew how to introduce nuances that influenced intellectuals in New York as Cultural Studies emerged.

Improvement on The Ellis and Roberts Viability Model

Directory of Open Access Journals (Sweden)

Guoyan Zhou

2016-05-01

Full Text Available With data sets of germination percent and storage time of seed lot of wheat and sorghum stored at three different storage temperature(t, °C with three different water content (m, % of seeds, together with data set of buckwheat and lettuce reported in literatures, the possibility that seed survival curve were transformed into line by survival proportion and the relationship that logarithm of average viability period (logp50 and standard deviation of seed death distribution in time (δwith t, m and interaction between t and m were analysed. Result indicated that survival proportion transformed seed survival curve to line were much easier than the probability adopted by Ellis and Roberts, and the most important factor affecting logp50 and δ of seed lot was interaction between t and m. Thus, Ellis and Roberts viability model were suggested to be improved as Ki=Vi-p/10K-CWT (t×m to predict longevity of seed lot with initial germination percent unknown, a new model of Gi/G0=A-P/10K-CWT(t×m was constructed to predict longevity of seed lot with initial germination percent already known.

Percy Julian, Robert Robinson, and the Identity of Eserethole

Science.gov (United States)

Ault, Addison

2008-01-01

The Nova production "Percy Julian--Forgotten Genius" included the very public disagreement between Percy Julian, an unknown American chemist, and Robert Robinson, possibly the best known organic chemist of the day, as to the identity of "eserethole", the key intermediate for the synthesis of the alkaloid physostigmine. The Nova production,…

John Bingham Roberts and the first American monograph on human brain surgery.

Science.gov (United States)

Stone, J L

2001-10-01

JOHN BINGHAM ROBERTS (1852-1924) of Philadelphia was an active general surgeon in the latter 19th and early 20th centuries. He made pioneering contributions to a number of areas of surgery. From 1880 until the end of his career, he was one of the few American surgeons to advocate an aggressive exploratory approach to cranial fractures in an effort to avoid consequences such as infection, delayed seizures, and insanity. In his 1885 article in the Transactions of the American Surgical Association titled "The Field and Limitation of the Operative Surgery of the Human Brain," he predicted that with antiseptic precautions and the growing knowledge of cerebral localization, operations on the brain would become commonplace. This work predated that of Horsley, Keen, and many others. Roberts had a continuing interest in head injuries, cranial fractures, and the development of trephines and burrs for reconstructive cranial work, but his active enthusiasm for brain surgery diminished in the 1890s. Nevertheless, Roberts was a very prolific teacher and leader in American surgery who is perhaps best remembered for his monographs and textbooks on general, orthopedic, plastic, and reconstructive surgery.

PRENATAL DIAGNOSIS OF ROBERT/SC SYNDROME IN A DIABETIC MOTHER WITH A HISTORY OF MEBENDAZOLE AND GLIBENCLAMIDE INTAKE

Directory of Open Access Journals (Sweden)

M. Pourissa

2003-07-01

Full Text Available The Robert/SC (pseudothalidomide syndrome is a rare autosomal recessive disorder, associated with phocomelia and craniofacial abnormalities. An anomalous fetus with lower limb phocomelia and micromelia, lumbar myeloschisis, upper limb and ribs defects and craniofacial abnormalities is reported whose diabetic mother took mebendazole and glibenclamide in early pregnancy. Ultrasonographic findings of syndromes with phocomelia are discussed as well as Robert/SC syndrome which is the most probable diagnosis. Robert/SC phocomelia syndrome is a rare autosomal recessive condition characterized by severe pre and postnatal growth deficiency, symmetric limb reductions of variable severity and craniofacial anomalies including hypertelorism, hypoplastic nasal alae, cleft lip and palate. About half of the reported cases presented chromosomal abnormalities. We think that findings in our case are consistent with Robert/SC syndrome with additional abnormalities.

78 FR 12357 - Brockway Mould, Inc., a Division of Ross International Ltd. Including Robert Lerch From BJR...

Science.gov (United States)

2013-02-22

... Division of Ross International Ltd. Including Robert Lerch From BJR Trucking, Brockport, PA; Amended..., applicable to workers and former workers of Brockway Mould, Inc., a division of Ross International Ltd... Brockway Mould, Inc., a division of Ross International Ltd., including Robert Lerch from BJR Trucking...

Robert Aymar seals the last interconnect in the LHC

CERN Multimedia

Maximilien Brice

2007-01-01

The LHC completes the circle. On 7 November, in a brief ceremony in the LHC tunnel, CERN Director General Robert Aymar (Photo 1) sealed the last interconnect between the main magnets of the Large Hadron Collider (LHC). Jean-Philippe Tock, leader of the Interconnections team, tightens the last bolt (Photos 4-8).

Robert Nozick's entitlement theory of justice: a critique | Nnajiofor ...

African Journals Online (AJOL)

The burden of this paper is to critique Robert Nozick's entitlement theory of justice which was drafted as an argument against traditional distribution theories. Nozick's theory of justice claims that whether a distribution is just or not depend entirely on how it came about. By contrast, justice according to equality, need, desert or ...

The strange trial of Robert Oppenheimer; L'etrange proces de Robert Oppenheimer

Energy Technology Data Exchange (ETDEWEB)

Kevles, D.J. [Yale Univ., New Haven, CT (United States); Institut de Technologie de Californie (United States)

2004-04-01

Robert Oppenheimer has become the symbol of the scientist tormented and anguished by the consequences of his discoveries. R.Oppenheimer took a major part in the Manhattan project for the designing of the first atomic bomb. During this period he considered the thermonuclear bomb as the next step to reach but after Japan's surrender he reconsidered his position and favoured a more moderate atomic policy. R.Oppenheimer began to militate in favour of an international control of nuclear energy and wanted that Usa relinquish to design the hydrogen bomb. In 1953 in full Mac-Carthysm era, he was accused of being a communist and of spying for Ussr and as a consequence he was deprived of his office in AEC (atomic energy committee) but in 1963 president Lyndon Johnson rehabilitated him and R.Oppenheimer was awarded the highest reward of AEC: the Enrico Fermi prize. (A.C.)

Robert Spitzer and psychiatric classification: technical challenges and ethical dilemmas.

Science.gov (United States)

Jacob, K S

2016-01-01

Dr Robert Leopold Spitzer (May 22, 1932-December 25, 2015), the architect of modern psychiatric diagnostic criteria and classification, died recently at the age of 83 in Seattle. Under his leadership, the American Psychiatric Association's (APA) Diagnostic and Statistical Manuals (DSM) became the international standard.

Wikinews interviews World Wide Web co-inventor Robert Cailliau

CERN Multimedia

2007-01-01

"The name Robert Caillau may not ring a bell to the general pbulic, but his invention is the reason why you are reading this: Dr. Cailliau together with his colleague Sir Tim Berners-Lee invented the World Wide Web, making the internet accessible so it could grow from an academic tool to a mass communication medium." (9 pages)

Conceptualising Childhood: Robert Louis Stevenson's "A Child's Garden of Verses."

Science.gov (United States)

Webb, Jean

2002-01-01

Discusses the construct of childhood in Robert Louis Stevenson's collection of poems, "A Child's Garden of Verses," by employing notions of child development drawn from Jean Piaget and Lev Vygotsky. Finds, from a literary perspective, Stevenson's collection located on the boundaries of romanticism and modernism. (BT)

75 FR 53861 - Airworthiness Directives; Robert E. Rust, Jr. Model DeHavilland DH.C1 Chipmunk 21, DH.C1 Chipmunk...

Science.gov (United States)

2010-09-02

... Airworthiness Directives; Robert E. Rust, Jr. Model DeHavilland DH.C1 Chipmunk 21, DH.C1 Chipmunk 22, and DH.C1...). ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for all Robert E. Rust... CFR part 39) to include an AD that would apply to all Robert E. Rust, Jr. Models DeHavilland DH.C1...

Robert Lacoste's the darker side practical applications for electronic design concepts from circuit cellar

CERN Document Server

Lacoste, Robert

2009-01-01

Robert Lacoste's The Darker Side column has quickly become a must read among Circuit Cellar devotees. His column provides readers with succinct theoretical concepts and practical applications on topics as far reaching as digital modulation to antenna basics. Difficult concepts are demystified as Robert shines a light on complex topics within electronic design.This book collects sixteen Darker Side articles that have been enriched with new, exclusive content from the author. An intro into The Darker Side will give examples of material that can enhance and optimize the way you design. A

Sprawl: A Compact History (Author: Robert Bruegmann)

OpenAIRE

Hayter, Jason Alexander

2006-01-01

Search a well-stocked library or bookstore for works on urban form and you might reach the same conclusion drawn by Robert Bruegmann: "Most of what has been written about sprawl to date has been written about com­ plaints" (p. 3). But what separates Bruegmann, a professor of art history, architecture, and urban planning at the University of Illinois at Chicago, from most people is what he does next. "[S]o many 'right-minded' people were so vociferous on the subject that I began to suspect tha...

Invited commentary on 'Robert G Edwards and the Roman Catholic Church'.

Science.gov (United States)

Head, Ivan Francis

2011-06-01

In this issue of Reproductive BioMedicine Online, Benagiano, Carrara and Filippi have produced a clearly written and comprehensive account of why the Roman Catholic Church has not welcomed the award of the 2010 Nobel Prize in Physiology and Medicine to Dr Robert G Edwards for the development of human IVF. I commend the article for its clarity and lucidity but attempt to point out some areas where disagreement even with its nuanced opposition to IVF may be legitimate. I try to make some simple comments that explain why this is so and I suggest some areas to which contemporary theology and philosophy can commit itself. But it is good to see even a nuanced response to the work of Robert G Edwards rather than a blanket condemnation. Copyright © 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

Robert J. Aumann - matemaatikust Nobeli preemia laureaat / Peeter Puusemp

Index Scriptorium Estoniae

Puusemp, Peeter, 1947-

2006-01-01

2005. a. Nobeli preemia majanduse alal silmapaistva panuse eest mänguteooria ülesannete lahendamisse saanud Robert J. Aumannist ja D. Saari loetelu matemaatikutest - Nobeli preemia laureaatidest: John Nash'ist, Herbert Hauptman'ist, John Pople'ist, Bertrand Arthur William Russell'ist, Kenneth Joseph Arrow'ist, Gerard Debreu'ist, Leonid Vitaljevitš Kantorovitš'ist, Reinhard Selten'ist, Jan Tinbergen'ist

Kablilt Casablancasse : Eesti suurim seikleja John Robert Ignace Lepp 100 / Vello Salo

Index Scriptorium Estoniae

Salo, Vello, 1925-

2009-01-01

Eesti päritolu seikleja John Robert Lepp, Prantsusmaal tuntud kui katoliku kiriku preester Ignace Lepp, avaldas prantsuse ja saksa keeles hulgaliselt raamatuid psühholoogia, filosoofia ja religiooni valdkonnast

PrP Knockout Cells Expressing Transmembrane PrP Resist Prion Infection.

Science.gov (United States)

Marshall, Karen E; Hughson, Andrew; Vascellari, Sarah; Priola, Suzette A; Sakudo, Akikazu; Onodera, Takashi; Baron, Gerald S

2017-01-15

Glycosylphosphatidylinositol (GPI) anchoring of the prion protein (PrP C ) influences PrP C misfolding into the disease-associated isoform, PrP res , as well as prion propagation and infectivity. GPI proteins are found in cholesterol- and sphingolipid-rich membrane regions called rafts. Exchanging the GPI anchor for a nonraft transmembrane sequence redirects PrP C away from rafts. Previous studies showed that nonraft transmembrane PrP C variants resist conversion to PrP res when transfected into scrapie-infected N2a neuroblastoma cells, likely due to segregation of transmembrane PrP C and GPI-anchored PrP res in distinct membrane environments. Thus, it remained unclear whether transmembrane PrP C might convert to PrP res if seeded by an exogenous source of PrP res not associated with host cell rafts and without the potential influence of endogenous expression of GPI-anchored PrP C To further explore these questions, constructs containing either a C-terminal wild-type GPI anchor signal sequence or a nonraft transmembrane sequence containing a flexible linker were expressed in a cell line derived from PrP knockout hippocampal neurons, NpL2. NpL2 cells have physiological similarities to primary neurons, representing a novel and advantageous model for studying transmissible spongiform encephalopathy (TSE) infection. Cells were infected with inocula from multiple prion strains and in different biochemical states (i.e., membrane bound as in brain microsomes from wild-type mice or purified GPI-anchorless amyloid fibrils). Only GPI-anchored PrP C supported persistent PrP res propagation. Our data provide strong evidence that in cell culture GPI anchor-directed membrane association of PrP C is required for persistent PrP res propagation, implicating raft microdomains as a location for conversion. Mechanisms of prion propagation, and what makes them transmissible, are poorly understood. Glycosylphosphatidylinositol (GPI) membrane anchoring of the prion protein (PrP C

Underwater EVA training in the WETF with astronaut Robert L. Stewart

Science.gov (United States)

1983-01-01

Underwater extravehicular activity (EVA) training in the weightless environment training facility (WETF) with astronaut Robert L. Stewart. Stewart is simulating a planned EVA using the mobile foot restraint device and a one-G version of the Canadian-built remote manipulator system.

A Pedagogy of Sight: Microscopic Vision in Robert Hooke's "Micrographia"

Science.gov (United States)

Jack, Jordynn

2009-01-01

Robert Hooke's "Micrographia" (1665) holds an important place in the history of scientific visual rhetoric. Hooke's accomplishment lies not only in a stunning array of engravings, but also in a "pedagogy of sight"--a rhetorical framework that instructs readers how to view images in accordance with an ideological or epistemic program. Hooke not…

76 FR 71369 - Robert G. Crummie, M.D.; Decision and Order

Science.gov (United States)

2011-11-17

... agencies to perform meaningless tasks. See Layfe Robert Anthony, M.D., 67 FR 35582 (DEA 2002); Michael G.... Kirk v. Mullen, 749 F.2d 297 (6th Cir. 1984); Puerto Rico Aqueduct and Sewer Auth. v. EPA, 35 F.3d 600...

[Robert Koch was right. Towards a new interpretation of tuberculin therapy].

Science.gov (United States)

Cardona, Pere J

2006-01-01

At the centenary of Robert Koch's Nobel Prize award, tuberculosis treatment with tuberculin, which was announced in Berlin in 1890, is still considered a failure. Nevertheless, there is now sufficient information supporting the idea that tuberculin therapy was widely used until the second half of the twentieth century; thus, the impact of this treatment should be studied and related to the decrease in tuberculosis-related mortality recorded in that period. Moreover, tuberculin therapy has inspired at least two new immunotherapies; these, however, were directed toward precisely the opposite effect: suppression of the Koch phenomenon. Thus, inoculation of Mycobacterium vaccae polarizes the immune response towards the Th1 type; and inoculation of RUTI avoids local immunodepression after short-term chemotherapy without inducing toxicity. For this reason, Robert Koch's work on antituberculosis therapy should be reread and proper recognition given to his contribution in this field.

Doctor Julius Robert Mayer and Energy Processes in Living Systems

Science.gov (United States)

Erlichson, Herman

2007-01-01

The overwhelming majority of important papers in physics are written by physicists. But the physician Julius Robert Mayer (1814-1878, see photo) did a valid theoretical calculation of the mechanical equivalent of heat just before Joule reported on his results from his well-known paddle-wheel experiments. Joule is well-known to physics people and…

ROBERT autonomous navigation robot with artificial vision

International Nuclear Information System (INIS)

Cipollini, A.; Meo, G.B.; Nanni, V.; Rossi, L.; Taraglio, S.; Ferjancic, C.

1993-01-01

This work, a joint research between ENEA (the Italian National Agency for Energy, New Technologies and the Environment) and DIGlTAL, presents the layout of the ROBERT project, ROBot with Environmental Recognizing Tools, under development in ENEA laboratories. This project aims at the development of an autonomous mobile vehicle able to navigate in a known indoor environment through the use of artificial vision. The general architecture of the robot is shown together with the data and control flow among the various subsystems. Also the inner structure of the latter complete with the functionalities are given in detail

Remediating Language Deficient/Dyslexic College Students: An Interview with Robert Nash.

Science.gov (United States)

Lundquist, Arlene J.; Nash, Robert

1988-01-01

Robert Nash responds to questions concerning his personal and professional background, the Simultaneous Multisensory Instructional Procedure for Teaching the Complete Sound Structure of the Language, problems associated with dyslexia, the social/emotional impact of learning disabilities, and the University of Wisconsin's Project Success for…

Kollaaž ja kontekst. Robert Rumase liiklusmärgid Tallinnas / Hanno Soans

Index Scriptorium Estoniae

Soans, Hanno, 1974-

2004-01-01

Sekkuv kunst. Poola kunstniku Robert Rumase (1966) rahvusvahelisest kunstiprojektist "Linnamanöövrid", Kai Kaljo videost "One way to see America", Krzysztof Wodicko "Kodutute projektsioonist" ja New York City Unioni väljaku ümberkorraldamisest

Must, valge + hall : Sam Wagstaffi ja Robert Mapplethorpe'i portree / Madis Palm

Index Scriptorium Estoniae

Palm, Madis

2008-01-01

Dokumentaalfilm "Black, White & Gray: Sam Wagstaff and Robert Mapplethorpe" : autor ja režissöör James Crump : Ameerika Ühendriigid 2007. Filmi näidati filminädala "Art in America" raames Tallinnas

On PR group classes and PR algebra membership

International Nuclear Information System (INIS)

Lebedenko, V.M.

1978-01-01

The necessary and sufficient conditions are found for the membership of Lee algebras to PR algebra class, to algebras with commutation relations of [Hsub(i), Hsub(j)]=rsub(ij)Hsub(i) (i< j) type. Due to this, a criterion is obtained for the membership of the Lee froups to PR group classes, connected and simply connected Lee groups, which Lee algebras are PR algebras

Drawings of fossils by Robert Hooke and Richard Waller

Science.gov (United States)

Kusukawa, Sachiko

2013-01-01

The drawings of fossils by Robert Hooke and Richard Waller that were the basis of the engravings in Hooke's Posthumous works (1705) are published here for the first time. The drawings show that both Hooke and Waller were proficient draftsmen with a keen eye for the details of petrified objects. These drawings provided Hooke with a polemic edge in making the case for the organic origins of ‘figured stones’.

Lydia J. Roberts's Nutrition Research and the Rhetoric of "Democratic" Science

Science.gov (United States)

Jack, Jordynn

2009-01-01

This article examines nutritionist Lydia J. Roberts's use of the "democratic approach" as a rhetorical strategy both to build solidarity among scientists and to enact participatory research in a rural Puerto Rican community. This example suggests that participatory scientific methodologies are not necessarily democratic but may function…

Neutron Scattering from fcc Pr and Pr3Tl

DEFF Research Database (Denmark)

Birgeneau, R. J.; Als-Nielsen, Jens Aage; Bucher, E.

1972-01-01

Elastic-neutron-scattering measurements on the singlet-ground-state ferromagnets fcc Pr and Pr3 Tl are reported. Both exhibit magnetic phase transitions, possibly to a simple ferromagnetic state at 20 and 11.6 °K, respectively. The transitions appear to be of second order although that in fcc Pr...

Gay theatre, AIDS, and taboo: reconsidering Robert Chesley.

Science.gov (United States)

Gavrila, Rebecca

2013-01-01

Theatre was among the first popular culture forms to address HIV/AIDS and did so memorably in such works as The Normal Heart, As Is, Love! Valor! Compassion!, and March of the Falsettos. As a response to criticisms of stage dramas focusing on HIV/AIDS in the main as undifferentiated and melodramatic, the author suggests critical consideration of two works by playwright Robert Chesley. In her analysis of Night Sweats and Jerker, the author argues Chesley offers an alternative perspective that is both liberatory and sex-positive.

Robert Hooke (1635-1703), in his own words.

Science.gov (United States)

Breathnach, C S

2003-11-01

The diaries and other writings of Robert Hooke (1635-1703), as well as those of his contemporaries, are drawn upon to sketch his social and scientific life. An account is presented of his involvement with the Royal Society from its earliest days, and of his relations with notable scientists. In exploring the similarity between combustion and respiration, he established that air is composed of different gases, and that it is not motion of the lungs but a supply of fresh air that is necessary for life.

The importance of chromosome studies in Roberts syndrome/SC phocomelia and other cohesinopathies.

Science.gov (United States)

Gerkes, Erica H; van der Kevie-Kersemaekers, Anne-Marie F; Yakin, Mariam; Smeets, Dominique F C M; van Ravenswaaij-Arts, Conny M A

2010-01-01

Roberts syndrome/SC phocomelia is a rare, autosomal recessive syndrome characterised by pre- and postnatal growth retardation, microcephaly, craniofacial anomalies, mental retardation, and tetraphocomelia in varying degrees of severity. The clinical diagnosis can be challenging in phenotypically mild cases. In the extremely mild case presented here, specific mitotic abnormalities were detected and proved to be very helpful, since Roberts syndrome/SC phocomelia could be diagnosed after finding premature centromere separation and somatic aneuploidy at routine karyotyping. We discuss these and other mitotic cytogenetic abnormalities that can be of significant diagnostic importance, but which will be missed if only array studies are performed. We also discuss the difference between premature centromere separation and premature (sister) chromatid separation. Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.

[Robert Schweitzer. Finnland, das Zarenreich und die Deutschen] / Karsten Bgüggemann

Index Scriptorium Estoniae

Brüggemann, Karsten, 1965-

2011-01-01

Arvustus: Robert Schweitzer. Finnland, das Zarenreich und die Deutschen : gesammelte Studien zum europäischen Nordosten. Festgabe zum 60. Geburtstag des Verfassers. Hrsg. von Uta-Maria Liertz. (Veröffentlichungen der Aue-Stiftung. Bd. 20) Verlag Schmidt-Römhild

A biography of Robert de Kersauson, French volunteer with the ...

African Journals Online (AJOL)

One of the most colourful foreign volunteers in the Boer army in 1900-1902 was Robert de Kersauson de Pennendreff; young, handsome, gallant and devoted to the Boer cause until the bitter end of the war. His love for South Africa brought him after an absence of almost 40 years back to this country to find a quiet place to ...

Marian Roberts, Developing the Craft of Mediation: Reflections on Theory and Practice

Directory of Open Access Journals (Sweden)

Ghislaine M. Lanteigne

2008-10-01

Full Text Available In Developing the Craft of Mediation, Marian Roberts proposes that mediation is akin to a craft with its focus on learning from experience and from others working in the field to develop and master knowledge and skills.

Tüli Robert Smithsoni "Spiraalse muuli" taastamise ümber / Rael Artel

Index Scriptorium Estoniae

Artel, Rael, 1980-

2004-01-01

Ameerika maakunstniku Robert Smithsoni (1938-1973) töö "Spiral Jetty" / "Spiraalne muul", mis on ligi 30 aastat seisnud nähtamatult Utah' osariigis Suure Soolajärve põhjas, on praegu kogu ulatuses näha. Teose omanik Dia kunstikeskus on dilemma ees, kas muul restaureerida või mitte

Estudo de dois mapas do geógrafo Robert de Vaugondy relativos ao Reino de Portugal do Século XVIII (1751

Directory of Open Access Journals (Sweden)

Marco Pais Neves dos Santos

2013-07-01

Full Text Available Analisamos dois mapas alusivos ao reino de Portugal, datados de 1751, publicados em Paris e assinados pelo geógrafo Robert de Vaugondy, a saber: Partie Septentrionale du Royaume de Portugal, par le Sr. Robert, Geographe ordinaire du Roy. Avec Privilege. 1751. e Partie Meridionale du Royaume de Portugal, par le Sr. Robert, Geographe ordinaire du Roy. Avec Privilege. 1751., com o objetivo de propor uma explicação para as divisões administrativas cartografadas. Como suporte ao objeto do trabalho, caracterizamos de forma concisa a evolução dos limites administrativos do reino de Portugal, desde a sua formação até a atualidade, e abordamos a vida e obra de Robert de Vaugondy. Concluímos ser o mais consentâneo com a lógica representarem divisões eclesiásticas.

Problem in Two Unknowns: Robert Hooke and a Worm in Newton's Apple.

Science.gov (United States)

Weinstock, Robert

1992-01-01

Discusses the place that Robert Hooke has in science history versus the scientific contributions he made. Examines the relationship between Hooke and his contemporary, Isaac Newton, and Hooke's claims that Newton built on his ideas without receiving Newton's recognition. (26 references) (MDH)

Isothermal sections of the state diagram for the Pr-Ni-Ge system at 870 (0-0,5Pr) and 670 K (0,5-1Pr)

International Nuclear Information System (INIS)

Fedyna, M.F.; Pecharskij, V.K.; Bodak, O.I.

1987-01-01

Method of X-ray phase and microstructural analyses were used to study Pr-Ni-Ge ternary system at 870K (0-0.50 at.fractions of Pr) and 670K (0.50-1.00 at.fractions of Pr). 11 ternary compounds exist in the system: Pr 1-x (NiGe) 13 (x=0.24), PrNi 2 Ge 2 , Pr 2 Ni 3 Ge 5 , PrNiGe 3 , Pr 2 NiGe 6 , Pr 3 Ni 4 Ge 4 , PrNi (1-x) Ge 2 (x=0.33), PrNiGe, Pr(NiGe) 2-x (x=0.14), Pr 3 NiGe 2 , ∼Pr 5 NiGe 4 . Crystal structure was determined for seven ternary compounds

Photoemission of heavy fermion superconductor PrOs4Sb12 and other Pr compounds

International Nuclear Information System (INIS)

Imada, S.; Yamasaki, A.; Sekiyama, A.; Settai, R.; Onuki, Y.; Suga, S.; Sugawara, H.; Sato, H.; Ochiai, A.

2004-01-01

Full text: Strongly correlated electronic states due to Pr 4f electrons found in several Pr compounds have recently been attracting much attention. The Pr 4f electrons are much more localized than in Ce due to the lanthanoid contraction. Therefore, the number of the Pr systems that show strong electron correlation is much smaller than Ce systems. We will present a comparative study of Pr 4f electronic states in such systems as the heavy fermion superconductor PrOs 4 Sb 12 , the Kondo system PrSn 3 and the localized 4f systems Pr 4 X 3 (X = Sb and Bi). The Pr 4f electronic state was probed by means of the Pr 3d → 4f resonant photoemission (RPES). Because the kinetic energy (E K ) of the photoelectrons is as high as ∼ 900 eV, this method is much more bulk sensitive than the 4d → 4f RPES with E K ∼ 100 eV. The energy resolution could be set to about 100 meV by utilizing the soft X-rays from BL25SU in SPring-8 and the SCIENTA SES-200 analyzer. The Pr 4f excitation spectrum of PrSn 3 was found to show a very strong intensity at the Fermi level (E F ). This can be interpreted as the Kondo resonance which has been observed in the Kondo Ce and Yb compounds. In the Pr 4f spectrum of the heavy fermion superconductor PrOs 4 Sb 12 , the intensity at E F was smaller than in PrSn 3 . This clearly shows that the Kondo temperature (T K ) is much lower in PrOs 4 Sb 12 than in PrSn 3 . We have further found a strong excitation energy dependence in the RPES line shape. In the case of Pr 4 X 3 (X = Sb and Bi), the intensity at E B was much smaller than PrSn 3 and PrOs 4 Sb 12 , which is consistent with the localized character of Pr 4f electrons in Pr 4 X 3 . The Pr 4f spectra of these localized systems are qualitatively well reproduced by a cluster model calculation that takes into account the hybridization between the Pr 4f orbital and the conduction and valence bands made up by the X p and Pr 5d states

Suured prügifirmad valmistuvad prügipuuduseks / Mirko Ojakivi

Index Scriptorium Estoniae

Ojakivi, Mirko

2010-01-01

Ragn-Sells ja Adelan Prügiveod soovivad luba jäätmete pikaajaliseks vaheladestamiseks Tallinna piiril. Ragn-Sells saaks jäätmekütusetehase planeerimise ja ehitamise ajal endale koguda ligi 35 000 t segaolmejäätmeid aastas, Adelan Prügiveod sooviks ladestada ligi 50 000 t prügi aastas

The importance of chromosome studies in Roberts syndrome/SC phocomelia and other cohesinopathies.

NARCIS (Netherlands)

Gerkes, E.H.; Kevie-Kersemaekers, A.M. van der; Yakin, M.; Smeets, D.F.C.M.; Ravenswaaij-Arts, C.M.A. van

2010-01-01

Roberts syndrome/SC phocomelia is a rare, autosomal recessive syndrome characterised by pre- and postnatal growth retardation, microcephaly, craniofacial anomalies, mental retardation, and tetraphocomelia in varying degrees of severity. The clinical diagnosis can be challenging in phenotypically

The importance of chromosome studies in Roberts syndrome/SC phocomelia and other cohesinopathies

NARCIS (Netherlands)

Gerkes, Erica H.; van der Kevie-Kersemaekers, Anne-Marie F.; Yakin, Mariam; Smeets, Dominique F. C. M.; van Ravenswaaij-Arts, Conny M. A.

2010-01-01

Roberts syndrome/SC phocomelia is a rare, autosomal recessive syndrome characterised by pre- and postnatal growth retardation, microcephaly, craniofacial anomalies, mental retardation, and tetraphocomelia in varying degrees of severity. The clinical diagnosis can be challenging in phenotypically

Le genre, le récit et le corps : « Aucun de nous ne reviendra » de Charlotte Delbo et « L’espèce humaine » de Robert Antelme

Directory of Open Access Journals (Sweden)

Silke Segler-Meßner

2015-06-01

Full Text Available L'article présente une relecture du premier volume de la Trilogie d’Auschwitz, Aucun de nous ne reviendra, de Charlotte Delbo dans une perspective du genre (dans le sens double de « genre littéraire » et de « gender » visant à analyser l’influence de la conscience d´être femme sur la mise en scène de la voix narrative ainsi que sur la présentation du monde concentrationnaire. Loin des généralisations stéréotypées, telles que la supposition d’une plus grande force morale dans le groupe des détenues féminines ou d’une plus grande solidarité entre les femmes l’article focalise les procédés narratifs et les images évoquées par le texte de Delbo qui sera comparé ensuite au récit L’espèce humaine de Robert Antelme. Dans la mesure où Charlotte Delbo et Robert Antelme s’obstinent à faire une histoire de leur expérience, il devient impossible d’associer leurs textes à un genre et, par conséquent, la lecture est contaminée par les effets d’une voix qui ne peut plus être située dans un cadre fixe ou un lieu concret. Ce « Je » qui parle appartient à un corps féminin ou masculin qui garde la mémoire traumatique et qui, en se transformant en un « nous », fonctionne comme un écran pour la souffrance et la mort des autres. Il reste alors à analyser les liens (secrets entre voix narrative, corps et genre, non pour rétablir le contexte biographique mais pour faire voir la naissance d’un sujet qui parle et qui, dans sa vulnérabilité, s’expose au regard des autres.

Robert Aymar awarded the Légion d’honneur

CERN Multimedia

CERN Bulletin

2011-01-01

  On 24 May, Robert Aymar, CERN Director-General from 2004 to 2008, was awarded the Légion d’honneur by the French authorities in recognition of his outstanding scientific career. A renowned French physicist, he was Director of the superconducting tokamak Tore Supra from 1977 to 1988, Director of Material Sciences at the CEA in 1990 and Director of the ITER project in 1994. His term of office as CERN Director-General was marked in particular by the commissioning and start-up of the LHC machine, which he inaugurated on 21 October 2008.        

Crystal Field Levels of Pr3+ in PrFeO3 and PrGaO3 Determined by Inelastic Neutron Scattering

DEFF Research Database (Denmark)

Feldmann, K.; Henning, K.; Kaun, L.

1975-01-01

The crystal field splitting of the 3H4 ground state of the Pr ion in PrFeO3 and PrGaO3 has been investigated by inelastic scattering of thermal neutrons. At several temperatures the transitions have been measured by TAS and TOF methods for polycrystalline PrFeO3 and by the TOF method...... for polycrystalline PrGaO3. Energy level schemes which are different for these materials are given....

Robert Hooke, inventor of the vacuum pump and the first altitude chamber (1671).

Science.gov (United States)

Harsch, Viktor

2006-08-01

Robert Hooke (1635-1703), an assistant researcher to Robert Boyle (1627-1691), invented the first functional British air pump. Applying it to scientific research, Hooke operated the world's first hypobaric chamber in 1671, using it for self-experimentation. He recorded the first physiological observations in an artificial altitude-equivalent environment up to 2400 m. Though Hooke's experiment showed some methodological insufficiencies, his imaginative experimental techniques were remarkable for their time and were indicative of the lively intellectual atmosphere of the Royal Society and the significant contributions of Hooke, who was a member. Two centuries passed before the French physiologist Paul Bert (1830-1886) conducted his famous laboratory-supported investigations of high altitude physiology. Bert played a decisive role in the discovery of the causes of decompression sickness; a contribution Hooke could not make due to the technical deficiencies of the 17th century.

PrP N-terminal domain triggers PrPSc-like aggregation of Dpl

International Nuclear Information System (INIS)

Erlich, Paul; Cesbron, Jean-Yves; Lemaire-Vieille, Catherine; Curt, Aurelie; Andrieu, Jean-Pierre; Schoehn, Guy; Jamin, Marc; Gagnon, Jean

2008-01-01

Transmissible spongiform encephalopathies are fatal neurodegenerative disorders thought to be transmitted by self-perpetuating conformational conversion of a neuronal membrane glycoprotein (PrP C , for 'cellular prion protein') into an abnormal state (PrP Sc , for 'scrapie prion protein'). Doppel (Dpl) is a protein that shares significant biochemical and structural homology with PrP C . In contrast to its homologue PrP C , Dpl is unable to participate in prion disease progression or to achieve an abnormal PrP Sc -like state. We have constructed a chimeric mouse protein, composed of the N-terminal domain of PrP C (residues 23-125) and the C-terminal part of Dpl (residues 58-157). This chimeric protein displays PrP-like biochemical and structural features; when incubated in presence of NaCl, the α-helical monomer forms soluble β-sheet-rich oligomers which acquire partial resistance to pepsin proteolysis in vitro, as do PrP oligomers. Moreover, the presence of aggregates akin to protofibrils is observed in soluble oligomeric species by electron microscopy

Bi3+–Pr3+ energy transfer processes and luminescent properties of LuAG:Bi,Pr and YAG:Bi,Pr single crystalline films

International Nuclear Information System (INIS)

Zorenko, Y.; Gorbenko, V.; Savchyn, V.; Zorenko, T.; Nikl, M.; Mares, J.A.; Beitlerova, A.; Jary, V.

2013-01-01

Absorption, cathodoluminescence, excitation spectra of photoluminescence (PL) and PL decay kinetics were studied at 300 K for the double doped with Bi 3+ –Pr 3+ and separately doped with Bi 3+ and Pr 3+ Lu 3 Al 5 O 12 (LuAG) and Y 3 Al 5 O 12 (YAG) single crystalline film (SCF) phosphors grown by the liquid phase epitaxy method. The emission bands in the UV range arising from the intrinsic radiative transitions of Bi 3+ based centers, and emission bands in the visible range, related to the luminescence of excitons localized around Bi 3+ based centers, were identified both in Bi–Pr and Bi-doped LuAG and YAG SCFs. The energy transfer processes from the host lattice simultaneously to Bi 3+ and Pr 3+ ions and from Bi 3+ to Pr 3+ ions were investigated. Competition between Pr 3+ and Bi 3+ ions in the energy transfer processes from the LuAG and YAG hosts was evidenced. The strong decrease of the intensity of Pr 3+ luminescence both in LuAG:Pr and YAG:Pr SCFs phosphors, grown from Bi 2 O 3 flux, is observed due to the quenching influence of Bi 3+ flux related impurity. Due to overlap of the UV emission band of Bi 3+ centers with the f–d absorption bands of Pr 3+ ions in the UV range and the luminescence of excitons localized around Bi ions with the f–f absorption bands of Pr 3+ ions in the visible range, an effective energy transfer from Bi 3+ ions to Pr 3+ ions takes place in LuAG:Bi,Pr and YAG:Bi,Pr SCFs, resulting in the appearance of slower component in the decay kinetics of the Pr 3+ d–f luminescence. -- Highlights: • Bi and Pr doped film phosphor grown by liquid phase epitaxy method. • Energy transfer from Bi 3+ to Pr 3+ ions. • Strong quenching of the Pr 3+ luminescence by Bi 3+ co-dopant

Hodorkovski advokaat : Venemaa ei ole õigusriik / Robert R. Amsterdam ; interv. Aleksei Günter

Index Scriptorium Estoniae

Amsterdam, Robert R.

2006-01-01

Ilmunud ka: Postimees : na russkom jazõke 24. juuli lk. 10. Naftamagnaadi Mihhail Hodorkovski advokaat vastab küsimustele, mis puudutavad ärimehe olukorda ja elamistingimusi vanglas ning tema võimalust ennetähtaegselt vabaneda. Lisa: Robert R. Amsterdam

An Environment for Treating Youthful Offenders: The Robert F. Kennedy Youth Center

Science.gov (United States)

Johnson, V. Scott

1977-01-01

Describes goals of the Robert F. Kennedy Youth Center (KYC) and the philosophical stance and the implementation of that philosophy within the center. Issues discussed range from administrative structure through descriptions of inmate classification and treatment. Educational and vocational programs as well as the token economy systems are…

Saksa filmilootusega tänavaelust ja hullusest / Robert Stadlober ; interv. Janno Zõbin

Index Scriptorium Estoniae

Stadlober, Robert

2002-01-01

Pimedate Ööde Filmifestivalil näidatud saksa mängufilmis "Engel & Joe" (režissöör Vanessa Jopp) ühes peaosas esines festivali külastanud saksa näitleja Robert Stadlober (1982). Näitleja Engeli rollist ja oma elukogemusest, mis aitas seda rolli kehastada

American Community Colleges in Crisis--A Conversation with Robert H. McCabe.

Science.gov (United States)

Dubocq, Tom

1981-01-01

Educational reform by Miami-Dade Community College is discussed by its president, Robert H. McCabe. In an action that is considered unusual for two-year schools, it has tightened controls on its curriculum, faculty, and students. A commitment to achieving higher levels of literacy is advocated. (MLW)

Looking Forward: Texas and Its Elderly. Highlights of the Robert Lee Sutherland Seminar (4th, Austin, Texas, May 12, 1984).

Science.gov (United States)

Coleman, Marion Tolbert, Ed.; And Others

This document presents the program agenda and highlights from the one-day Robert Lee Sutherland Seminar held to examine the current status and the future of the elderly population of Texas. Included is the speech, "The Longevity Revolution" by Robert N. Butler, in which is discussed the gain in life expectancy, the feminization of aging,…

Feminism and Faith: Exploring Christian Spaces in the Writing of Sara Maitland and Michèle Roberts

Directory of Open Access Journals (Sweden)

Arina LUNGU-CIRSTEA

2011-03-01

érentes – la dimension fondatrice de l’identité occidentale contemporaine.Quel que soit le choix personnel de ces auteures, la spiritualité chrétienne se révèle être un facteur clé pour déterminer le lieu précis qu’elles - ou leurs héroïnes - occupent dans le monde social. Prenant comme point de départ l’idée que “les identités du lieu sont toujours variables, attaquées et multiples” (Doreen Massey, cet article se concentre sur les efforts que déploient ces écrivaines pour affirmer l’identité spirituelle des femmes contre les frontières rigides de l’espace social.In 1983, British feminists Sara Maitland and Jo Garcia edited Walking on the Water (London: Virago, a collection of “essays, stories, poems and pictures by women about spirituality”. Contributors had been invited in particular to explore the relationship between their feminist identity and their religious beliefs. The tone of these contributions was extremely diverse, ranging from the passionate urge to reconcile the goals of feminism with Christianity to a complete rejection of the Church as the paramount patriarchal institution.This essay engages with these diametrically opposed narratives on Christianity and feminism as pictured in the writing of two of the contributors, Sara Maitland (1950- and Michèle Roberts (1949-. Both writers have been actively involved in the feminist movements of the 1970s, and have struggled to come to terms with their Christian heritage. Nonetheless while Maitland focused on revising Christianity by making it incorporate essential points on the feminist agenda, Roberts felt the imperious need to discard her religious identity in order to become “her own woman”; moreover, in her 2007 autobiography Paper Houses she describes her Catholic upbringing as “authoritarian and misogynistic” (16.My essay addresses questions regarding the challenge of articulating one’s spiritual identity as a concatenation of feminism and faith; with this end in

78 FR 51802 - Culturally Significant Objects Imported for Exhibition Determinations: “Robert Motherwell: The...

Science.gov (United States)

2013-08-21

... ``Robert Motherwell: The Early Collages,'' imported from abroad for temporary exhibition within the United... the Solomon R. Guggenheim Museum, New York, New York, from on or about September 27, 2013, until on or...

Robert Priddle talking straight

International Nuclear Information System (INIS)

Anon

2000-01-01

A keynote speaker at Outlook 2001 conference, Robert Priddle, Executive Director of the International Energy Agency, provided a realistic assessment of the opportunities for a change in the energy supply mix in the light of the growing international debate about the design of a sustainable energy future. World energy supply today is based firmly on fossil fuels. Furthermore, projections of future supply, such as that made in the reference case of the recent World Energy Outlook by the IEA, indicate little change. Yet government's remain deeply engaged in efforts to reshape energy markets including (despite the failure of COP-6 in The Hague last November) efforts to curb national emissions of greenhouse gases, in particular from the energy sector. Australia has made considerable progress in developing and applying life cycle analysis to the energy sector. This effort demonstrates opportunities to combine, for example, coal seam methane capture, coal and biomass co-combustion, coal power generation and steel production and thus to reduce emissions by up to 15%. The prospect is that even with effective carbon constraints reflected in fuel prices, coal can remain a competitive fuel choice for longer than many analysts imagine. The outcome does not rely on exotic technology development, rather it requires the necessary market signals to create new business partnerships

Robert Owen: A Historiographic Study of a Pioneer of Human Resource Development

Science.gov (United States)

Hatcher, Tim

2013-01-01

Purpose: The purpose of this paper is to investigate the ideals and activities of the nineteenth century Welsh industrialist and reformer Robert Owen (1771-1858), and how they informed modern human resource development (HRD) concepts and practices and provided evidence of Owen as a HRD pioneer. Design/methodology/approach: Historiography provided…

Research, Learning Theory, and the Ideas of Robert G. Sidnell. Special Issue.

Science.gov (United States)

Alexander, David, Ed.; And Others

1987-01-01

Intended as a memorial to Robert G. Sidnell, this special issue contains articles about areas of music education which he promoted. In "The Dimensions of Research in Music Education," Sidnell concluded that music education research encompasses all humanistic disciplines as well as the behavioral and social sciences. James Carlsen, in…

The molecular mechanism underlying Roberts syndrome involves loss of ESCO2 acetyltransferase activity

NARCIS (Netherlands)

Gordillo, Miriam; Vega, Hugo; Trainer, Alison H.; Hou, Fajian; Sakai, Norio; Luque, Ricardo; Kayserili, Hülya; Basaran, Seher; Skovby, Flemming; Hennekam, Raoul C. M.; Uzielli, Maria L. Giovannucci; Schnur, Rhonda E.; Manouvrier, Sylvie; Chang, Susan; Blair, Edward; Hurst, Jane A.; Forzano, Francesca; Meins, Moritz; Simola, Kalle O. J.; Raas-Rothschild, Annick; Schultz, Roger A.; McDaniel, Lisa D.; Ozono, Keiichi; Inui, Koji; Zou, Hui; Jabs, Ethylin Wang

2008-01-01

Roberts syndrome/SC phocomelia (RBS) is an autosomal recessive disorder with growth retardation, craniofacial abnormalities and limb reduction. Cellular alterations in RBS include lack of cohesion at the heterochromatic regions around centromeres and the long arm of the Y chromosome, reduced growth

Using Performance as an Interpretive Strategy in Teaching Robert Browning's "My Last Duchess."

Science.gov (United States)

Schevera, Nicholas

1997-01-01

Uses role-playing, dramatic monologues, and "tableaux vivant" to interpret Robert Browning's poem "My Last Duchess" in an introductory literature class at Westchester Community College. Notes that performative strategies illustrate connections in the poem that often remain unnoticed on a first reading. (PA)

The strange trial of Robert Oppenheimer

International Nuclear Information System (INIS)

Kevles, D.J.

2004-01-01

Robert Oppenheimer has become the symbol of the scientist tormented and anguished by the consequences of his discoveries. R.Oppenheimer took a major part in the Manhattan project for the designing of the first atomic bomb. During this period he considered the thermonuclear bomb as the next step to reach but after Japan's surrender he reconsidered his position and favoured a more moderate atomic policy. R.Oppenheimer began to militate in favour of an international control of nuclear energy and wanted that Usa relinquish to design the hydrogen bomb. In 1953 in full Mac-Carthysm era, he was accused of being a communist and of spying for Ussr and as a consequence he was deprived of his office in AEC (atomic energy committee) but in 1963 president Lyndon Johnson rehabilitated him and R.Oppenheimer was awarded the highest reward of AEC: the Enrico Fermi prize. (A.C.)

Summary Robert Noyce and the invention of Silicon Valley

CERN Document Server

2014-01-01

This work offers a summary of the book "THE MAN BEHIND THE MICROCHIP: Robert Noyce and the Invention of Silicon Valley""by Leslie Berlin.The Man behind the Microchip is Leslie Berlin's first book. This author is project historian for the Silicon Valley Archives, a division of the Stanford University Department of Special Collections. This book tells the story of a giant of the high-tech industry: the multimillionaire Bob Noyce. This co-founder of Fairchild Semiconductor and Intel co-invented the integrated circuit which became the electronic heart of every modern computer, automobile, advance

Robert Wiltrout Says Goodbye to NCI in 2015 | Poster

Science.gov (United States)

After 34 years at NCI, Robert Wiltrout, Ph.D., said he is looking forward to trading his I-270 commute for another type of commute: exploring the waterways of Maryland, Alaska, and Wyoming to fulfill his love of fishing. Wiltrout officially retired as director of the NCI Center for Cancer Research (CCR) on July 2 of last year. Throughout his college academic career, Wiltrout had an interest in science, but it was not until he was working on a research project for his master’s degree that he considered a career in scientific research.

Welcoming the Sunlight: A Conversation with Mary Kay Zabel and Robert Zabel

Science.gov (United States)

Teagarden, James; Kaff, Marilyn

2018-01-01

Professors Emeriti Mary Kay and Robert Zabel share their reflections on their long and productive careers working with students and teachers. Their respective careers share much of the same history and complement each other. The Zabels share their advice with those entering the field and the challenges they see for the education of students with…

The scientific careers of Robert Sinclair and Nestor Zaluzec - A brief sketch

Energy Technology Data Exchange (ETDEWEB)

Fraser, Hamish L. [The Ohio State University (United States); Smith, David J., E-mail: david.smith@asu.edu [Arizona State University (United States); Wittig, James E. [Vanderbilt University (United States)

2017-05-15

Robert (Bob) Sinclair and Nestor Zaluzec have been working for many years at the leading edge of developments in electron microscopy techniques and applications. Their distinguished careers and some of their notable scientific achievements are briefly highlighted. - Highlights: • Biographical sketch of Bob Sinclair • Biographical Sketch of Nestor Zaluzec • Scientific career highlights.

The scientific careers of Robert Sinclair and Nestor Zaluzec - A brief sketch

International Nuclear Information System (INIS)

Fraser, Hamish L.; Smith, David J.; Wittig, James E.

2017-01-01

Robert (Bob) Sinclair and Nestor Zaluzec have been working for many years at the leading edge of developments in electron microscopy techniques and applications. Their distinguished careers and some of their notable scientific achievements are briefly highlighted. - Highlights: • Biographical sketch of Bob Sinclair • Biographical Sketch of Nestor Zaluzec • Scientific career highlights

Interaction between Shadoo and PrP Affects the PrP-Folding Pathway.

Science.gov (United States)

Ciric, Danica; Richard, Charles-Adrien; Moudjou, Mohammed; Chapuis, Jérôme; Sibille, Pierre; Daude, Nathalie; Westaway, David; Adrover, Miguel; Béringue, Vincent; Martin, Davy; Rezaei, Human

2015-06-01

Prion diseases are characterized by conformational changes of a cellular prion protein (PrP(C)) into a β-sheet-enriched and aggregated conformer (PrP(Sc)). Shadoo (Sho), a member of the prion protein family, is expressed in the central nervous system (CNS) and is highly conserved among vertebrates. On the basis of histoanatomical colocalization and sequence similarities, it is suspected that Sho and PrP may be functionally related. The downregulation of Sho expression during prion pathology and the direct interaction between Sho and PrP, as revealed by two-hybrid analysis, suggest a relationship between Sho and prion replication. Using biochemical and biophysical approaches, we demonstrate that Sho forms a 1:1 complex with full-length PrP with a dissociation constant in the micromolar range, and this interaction consequently modifies the PrP-folding pathway. Using a truncated PrP that mimics the C-terminal C1 fragment, an allosteric binding behavior with a Hill number of 4 was observed, suggesting that at least a tetramerization state occurs. A cell-based prion titration assay performed with different concentrations of Sho revealed an increase in the PrP(Sc) conversion rate in the presence of Sho. Collectively, our observations suggest that Sho can affect the prion replication process by (i) acting as a holdase and (ii) interfering with the dominant-negative inhibitor effect of the C1 fragment. Since the inception of the prion theory, the search for a cofactor involved in the conversion process has been an active field of research. Although the PrP interactome presents a broad landscape, candidates corresponding to specific criteria for cofactors are currently missing. Here, we describe for the first time that Sho can affect PrP structural dynamics and therefore increase the prion conversion rate. A biochemical characterization of Sho-PrP indicates that Sho acts as an ATP-independent holdase. Copyright © 2015, American Society for Microbiology. All Rights

Recombinant PrPSc shares structural features with brain-derived PrPSc: Insights from limited proteolysis.

Science.gov (United States)

Sevillano, Alejandro M; Fernández-Borges, Natalia; Younas, Neelam; Wang, Fei; R Elezgarai, Saioa; Bravo, Susana; Vázquez-Fernández, Ester; Rosa, Isaac; Eraña, Hasier; Gil, David; Veiga, Sonia; Vidal, Enric; Erickson-Beltran, Melissa L; Guitián, Esteban; Silva, Christopher J; Nonno, Romolo; Ma, Jiyan; Castilla, Joaquín; R Requena, Jesús

2018-01-01

Very solid evidence suggests that the core of full length PrPSc is a 4-rung β-solenoid, and that individual PrPSc subunits stack to form amyloid fibers. We recently used limited proteolysis to map the β-strands and connecting loops that make up the PrPSc solenoid. Using high resolution SDS-PAGE followed by epitope analysis, and mass spectrometry, we identified positions ~116/118, 133-134, 141, 152-153, 162, 169 and 179 (murine numbering) as Proteinase K (PK) cleavage sites in PrPSc. Such sites likely define loops and/or borders of β-strands, helping us to predict the threading of the β-solenoid. We have now extended this approach to recombinant PrPSc (recPrPSc). The term recPrPSc refers to bona fide recombinant prions prepared by PMCA, exhibiting infectivity with attack rates of ~100%. Limited proteolysis of mouse and bank vole recPrPSc species yielded N-terminally truncated PK-resistant fragments similar to those seen in brain-derived PrPSc, albeit with varying relative yields. Along with these fragments, doubly N- and C-terminally truncated fragments, in particular ~89/97-152, were detected in some recPrPSc preparations; similar fragments are characteristic of atypical strains of brain-derived PrPSc. Our results suggest a shared architecture of recPrPSc and brain PrPSc prions. The observed differences, in particular the distinct yields of specific PK-resistant fragments, are likely due to differences in threading which result in the specific biochemical characteristics of recPrPSc. Furthermore, recombinant PrPSc offers exciting opportunities for structural studies unachievable with brain-derived PrPSc.

James George Frazer’s Anthropologic Heritage in the Work of Robert Graves

Directory of Open Access Journals (Sweden)

Tomislav M. Pavlović

2016-02-01

Full Text Available The works of Sir James George Frazer had an outstanding influence on the literature of modernism. Among those who benefited from Frazer’s ritualism were W. B. Yeats, T. S. Eliot. James Joyce, Ernest Hemingway, D. H. Lawrence, Ezra Pound, Mary Renault, Joseph Campbell, Robert Graves and many others. Robert Graves was known for his famous adaptation of Frazer’s concept of the sacred king who is sacrificed for the benefit of his subjects thus forming the narrative frame for the one of his most controversial novels. The dying king is also identified with the poet striving to attain the favour of the Triple Muse Goddess - who represents the embodiment of true poetic inspiration. The aforementioned concept is not the only thing that Graves inherited from his famous ancestor. In our analysis we laid stress on the customs, rituals, magic symbols and deities both authors dealt with. We also observed a striking resemblance of the style Greves and Frazer developed and their euchemeristic approach to myths as well.

Pr-magnetism in the quasi-skutterudite compound PrFe2Al8.

Science.gov (United States)

Nair, Harikrishnan S; Ogunbunmi, Michael O; Kumar, C M N; Adroja, D T; Manuel, P; Fortes, D; Taylor, J; Strydom, A M

2017-08-31

The intermetallic compound PrFe 2 Al 8 that possesses a three-dimensional network structure of Al polyhedra centered at the transition metal element Fe and the rare earth Pr is investigated through neutron powder diffraction and inelastic neutron scattering in order to elucidate the magnetic ground state of Pr and Fe and the crystal field effects of Pr. Our neutron diffraction study confirms long-range magnetic order of Pr below [Formula: see text] K in this compound. Subsequent magnetic structure estimation reveals a magnetic propagation vector [Formula: see text] with a magnetic moment value of [Formula: see text]/Pr along the orthorhombic c-axis and evidence the lack of ordering in the Fe sublattice. The inelastic neutron scattering study reveals one crystalline electric field excitation near 19 meV at 5 K in PrFe 2 Al 8 . The energy-integrated intensity of the 19 meV excitation as a function of [Formula: see text] follows the square of the magnetic form factor of [Formula: see text] thereby confirming that the inelastic excitation belongs to the Pr sublattice. The second sum rule applied to the dynamic structure factor indicates only 1.6(2) [Formula: see text] evolving at the 19 meV peak compared to the 3.58 [Formula: see text] for free [Formula: see text], indicating that the crystal field ground state is magnetic and the missing moment is associated with the resolution limited quasi-elastic line. The magnetic order occurring in Pr in PrFe 2 Al 8 is counter-intuitive to the symmetry-allowed crystal field level scheme, hence, is suggestive of exchange-mediated mechanisms of ordering stemming from the magnetic ground state of the crystal field levels.

State diagram of Pr-Bi system

International Nuclear Information System (INIS)

Abulkhaev, V.L.; Ganiev, I.N.

1994-01-01

By means of thermal differential analysis, X-ray and microstructural analysis the state diagram of Pr-Bi system was studied. Following intermetallic compounds were defined in the system: Pr 2 Bi, Pr 5 Bi 3 , Pr 4 Bi 3 , Pr Bi, PrBi 2 , Pr 2 Bi, Pr 5 Bi 3 , Pr 4 Bi 3 and PrBi 2 . The data analysis on Ln-Bi diagram allowed to determine the regularity of change of properties of intermetallic compounds in the line of rare earth elements of cerium subgroup.

Tim, Jan Lucas ja Karl Robert - vennad üheks kuuks / Maris Laurits

Index Scriptorium Estoniae

Laurits, Maris

2009-01-01

Rakvere Teatri suvelavastuse "Vennad Lõvisüdamed" kaks Karli osatäitjat Jan Lucas Videvik ja Tim Leesnurm ning Joonatani osatäitja Karl Robert Saaremäe tegid Loksal Kaldmaa talus ratsasõiduproove. Üllar Saaremäe lavastuse "Vennad Lõvisüdamed" (Astrid Lindgreni samanimelise jutustuse järgi) esietendus on 11. juunil Rakvere teatri taga aias

Robert Musil y los Estados desunificados de Europa

Directory of Open Access Journals (Sweden)

Bayón, Fernando

2006-12-01

Full Text Available This article is a study of Robert Musil´s work “The Man Without Qualities” from philosophical sources. It is a novel that has produced so many overriding metaphors through which we can better understand the crises of the social identity on the horizont of the last modernity in Europe. Much of the key-concepts that helped in creating the so called “Leyend of Modernity” start to vanish in an irremediable way: not only did Musil trace the disappearance of the support for national aspirations and social cohesion, he also showed us how culture is a mad carrousel of collapsed expectations, and how the prevailing idea of “subjectivity” lacks today any solid or essential nucleus. In the middle of this disenchanted landscape of Europe, where all the modern and clasical illusions became nothing, appears however “a new human being”, since the man “without qualities” is the man with endless possibilities too.El presente ensayo es una interpretación de la novela de Robert Musil “El hombre sin atributos” a partir de fuentes filosóficas. Se trata de una obra que ha producido algunas metáforas decisivas para comprender las crisis de la identidad social en el horizonte de la última modernidad europea. Muchos de los conceptos clave que ayudaron a crear la leyenda de la modernidad empiezan a erosionarse de modo irreversible: se descomponen las aspiraciones nacionales, el sujeto pierde su núcleo sustancial y la cultura es un carrusel de esperanzas abortadas incapaces de responder a ninguna idea rectora. Y, sin embargo, en el paisaje de esta Europa tardomoderna en que se han agotado las pasadas ilusiones surge la idea de que el “hombre sin atributos” es también el “hombre de las posibilidades”.

Robert Hooke: early respiratory physiologist, polymath, and mechanical genius.

Science.gov (United States)

West, John B

2014-07-01

Robert Hooke (1635-1703) was a polymath who made important contributions to respiratory physiology and many other scientific areas. With Robert Boyle, he constructed the first air pump that allowed measurements on small animals at a reduced atmospheric pressure, and this started the discipline of high-altitude physiology. He also built the first human low-pressure chamber and described his experiences when the pressure was reduced to the equivalent of an altitude of ∼2,400 m. Using artificial ventilation in an animal preparation, he demonstrated that movement of the lung was not essential for life. His book Micrographia describing early studies with a microscope remains a classic. He produced an exquisite drawing of the head of a fly, showing the elaborate compound eye. There is also a detailed drawing of a flea, and Hooke noted how the long, many-jointed legs enable the insect to jump so high. For 40 years, he was the curator of experiments for the newly founded Royal Society in London and contributed greatly to its intellectual ferment. His mechanical inventions covered an enormous range, including the watch spring, the wheel barometer, and the universal joint. Following the Great Fire of London in 1666, he designed many of the new buildings in conjunction with Christopher Wren. Unfortunately, Hooke had an abrasive personality, which was partly responsible for a lack of recognition of his work for many years. However, during the last 25 years, there has been renewed interest, and he is now recognized as a brilliant scientist and innovator. ©2014 Int. Union Physiol. Sci./Am. Physiol. Soc.

Robert Frazure mälestuspuu Sõpruse pargis sai graniitpotil tähistuse / Raivo Feldmann

Index Scriptorium Estoniae

Feldmann, Raivo

2007-01-01

Esimese USA suursaadiku sõjajärgses Eestis, Robert Frazure' mälestuspuu sai Sõpruse pargis tähise, vajaliku raha ettevõtmise heaks annetasid Ameerika Suursaatkonna töötajad, nende delegatsioon viibis Põltsamaal Sõpruse pargis toimunud üritusel

Improvements to the Understanding of the Fire Performance of Wood over the Past 30 Years-A Tribute to Robert Hawthorne White

Science.gov (United States)

Samuel L. Zelinka; Mark A. Dietenberger; Laura E. Hasburgh; Keith J. Bourne; Charles Boardman

2015-01-01

Dr. Robert Hawthorne White had a 31 year career researching the fire performance of wood and wood composites at the USDA Forest Products Laboratory. Over his career, Dr. White made substantial contributions to codes, standards, and regulations pertaining to the design of wood structures. This review article summarizes Robert’s major accomplishments as a tribute to his...

Prion protein (PrP) gene-knockout cell lines: insight into functions of the PrP

Science.gov (United States)

Sakudo, Akikazu; Onodera, Takashi

2015-01-01

Elucidation of prion protein (PrP) functions is crucial to fully understand prion diseases. A major approach to studying PrP functions is the use of PrP gene-knockout (Prnp−/−) mice. So far, six types of Prnp−/− mice have been generated, demonstrating the promiscuous functions of PrP. Recently, other PrP family members, such as Doppel and Shadoo, have been found. However, information obtained from comparative studies of structural and functional analyses of these PrP family proteins do not fully reveal PrP functions. Recently, varieties of Prnp−/− cell lines established from Prnp−/− mice have contributed to the analysis of PrP functions. In this mini-review, we focus on Prnp−/− cell lines and summarize currently available Prnp−/− cell lines and their characterizations. In addition, we introduce the recent advances in the methodology of cell line generation with knockout or knockdown of the PrP gene. We also discuss how these cell lines have provided valuable insights into PrP functions and show future perspectives. PMID:25642423

Prion protein (PrP) gene-knockout cell lines: insight into functions of the PrP

OpenAIRE

Sakudo, Akikazu; Onodera, Takashi

2015-01-01

Elucidation of prion protein (PrP) functions is crucial to fully understand prion diseases. A major approach to studying PrP functions is the use of PrP gene-knockout (Prnp ?/?) mice. So far, six types of Prnp ?/? mice have been generated, demonstrating the promiscuous functions of PrP. Recently, other PrP family members, such as Doppel and Shadoo, have been found. However, information obtained from comparative studies of structural and functional analyses of these PrP family proteins do not ...

Revisiting progesterone receptor (PR) actions in breast cancer: Insights into PR repressive functions.

Science.gov (United States)

Proietti, Cecilia J; Cenciarini, Mauro E; Elizalde, Patricia V

2018-05-01

Progesterone receptor (PR) is a master regulator in female reproductive tissues that controls developmental processes and proliferation and differentiation during the reproductive cycle and pregnancy. PR also plays a role in progression of endocrine-dependent breast cancer. As a member of the nuclear receptor family of ligand-dependent transcription factors, the main action of PR is to regulate networks of target gene expression in response to binding its cognate steroid hormone, progesterone. Liganded-PR transcriptional activation has been thoroughly studied and associated mechanisms have been described while progesterone-mediated repression has remained less explored. The present work summarizes recent advances in the understanding of how PR-mediated repression is accomplished in breast cancer cells and highlights the significance of fully understanding the determinants of context-dependent PR action. Copyright © 2018 Elsevier Inc. All rights reserved.

The man behind the microchip Robert Noyce and the invention of Silicon Valley

CERN Document Server

Berlin, Leslie

2005-01-01

Robert Noyce was a brilliant inventor, a leading entrepreneur and a daring risk taker, who piloted his own jets and skied mountains accessible only by helicopter. This book captures not only this colorful individual, but also the vibrant interplay of technology, business, money, politics and culture that defines the Silicon Valley.

USA kaitseminister Robert Gates süüdistas liitlasvägesid oskamatuses / Evelyn Kaldoja

Index Scriptorium Estoniae

Kaldoja, Evelyn, 1980-

2008-01-01

USA kaitseminister Robert Gates väitis ajalehes The Los Angeles Times avaldatud intervjuus, et Lõuna-Afganistani olukord on halvenenud seal võitlevate USA liitlasvägede puuduliku väljaõppe tõttu. Liitlasriikide reageeringuid. Arvamust avaldavad Jaak Aaviksoo, Kaarel Kaas

Changements à la tête du CERN - Robert Aymar aux commandes pour 5 ans.

CERN Multimedia

2003-01-01

"Une nouvelle équipe prendra les rênes du CERN à partir du 1er janvier. Le Francais Robert Aymar, anciennement directeur du Projet de reacteur thermonucleaire experimental international (ITER), dirigera le centre de recherche pour la periode 2004-2008" (1 page).

Cosmic Thing: Astrology, Space Science, and Personal Cartography in Robert Rauschenberg's Autobiography

Science.gov (United States)

Carey, C. L.

2011-06-01

The following paper undertakes an iconographic analysis of Robert Rauschenberg's large scale print, Autobiography (1967). The artist's interest in astronomy and astrology, visual metaphors aligning the body with the cosmos, and the cartographic representation of self are discussed. Autobiography is placed in cultural and historical context with other works by the artist, elaborated as a personal narrative-an alternative to traditional self portraiture.

Phase diagram of Pr-P system

International Nuclear Information System (INIS)

Mironov, K.E.

1981-01-01

An area of the Pr-P system, adjoining to the Pr ordinate, is plotted up by the DTA method. Presence of P solid solution in Pr is established. Data on thermal stability of PrP, PrP 2 , PrP 5 and PrP 7 are generalized. The diagram of phase transformations in Pr-P system is plotted up proceeding from the whole complex of the data, presented. A supposition is made on a possible formation of solid solutions between the highest polyphosphide and phosphorus [ru

Homosexual orientation-from nature, not abuse: A critique of Roberts, Glymour, and Koenen (2013).

Science.gov (United States)

Rind, Bruce

2013-11-01

Roberts, Glymour, and Koenen (2013), using instrumental variable models, argued that child abuse causes homosexual orientation, defined in part as any same-sex attractions. Their instruments were various negative family environment factors. In their analyses, they found that child sexual abuse (CSA) was more strongly related to homosexual orientation than non-sexual maltreatment was, especially among males. The present commentary therefore focused on male CSA. It is argued that Roberts et al.'s "abuse model" is incorrect and an alternative is presented. Male homosexual behavior is common in primates and has been common in many human societies, such that an evolved human male homosexual potential, with individual variation, can be assumed. Cultural variation has been strongly influenced by cultural norms. In our society, homosexual expression is rare because it is counternormative. The "counternormativity model" offered here holds that negative family environment weakens normative controls and increases counternormative thinking and behavior, which, in combination with sufficient homosexual potential and relevant, reinforcing experiences, can produce a homosexual orientation. This is a benign or positive model (innate potential plus release and reinforcement), in contrast to Roberts et al.'s negative model (abuse plus emotional compensation or cognitive distortion). The abuse model is criticized for being based on the sexual victimological paradigm, which developed to describe the female experience in rape and incest. This poorly fits the gay male experience, as demonstrated in a brief non-clinical literature review. Validly understanding male homosexuality, it is argued, requires the broad perspective, as employed here.

Color and Contingency in Robert Boyle's Works.

Science.gov (United States)

Baker, Tawrin

2015-01-01

This essay investigates the relationship between color and contingency in Robert Boyle's Experiments and Considerations Touching Colours (1664) and his essays on the unsuccessfulness of experiments in Certain Physiological Essays (1661). In these two works Boyle wrestles with a difficult practical and philosophical problem with experiments, which he calls the problem of contingency. In Touching Colours, the problem of contingency is magnified by the much-debated issue of whether color had any deep epistemic importance. His limited theoretical principle guiding him in Touching Colours, that color is but modified light, further exacerbated the problem. Rather than theory, Boyle often relied on craftsmen, whose mastery of color phenomena was, Boyle mentions, brought about by economic forces, to determine when colors were indicators of important 'inward' properties of substances, and thus to secure a solid foundation for his experimental history of color.

Cu4Pr6(MoO4)11-Pr2(MoO4)3 system

International Nuclear Information System (INIS)

Arzumanyan, G.A.

1982-01-01

Existence boundaries and Dalton compositions (CuPr(MoO 4 ) 2 , CuPr 3 (MoO 4 ) 5 ) of solid solutions that in the mojority are of shcheelite dsitored structure have been determined in the Cu 4 Pr 6 (MoO 4 ) 11 -Pr 2 (MoO 4 ) 3 system. It has been revealed that regions of homogeneity near the CuPr(MoO 4 ) 2 composition have a horseshoeshaped profile

The creativity of Crumb: research on the effects of psychedelic drugs on the comic art of Robert Crumb.

Science.gov (United States)

Jones, Matthew T

2007-09-01

This article investigates the influence of perception that is altered by psychedelic drugs on processes of creativity through a case study of the work of well-known comic artist Robert Crumb. Samples of Crumb's work before, during, and after the period of his use of psychedelic drugs are content analyzed and compared according to the categorization offered by Janiger and Dobkin de Rios (1989). The results of the comparison indicate that Robert Crumb's drug use significantly altered the stylistic approach of his artwork not only during the period of his drug use, but long after he had stopped using drugs.

Robert Kramer: técnica, paixão e ideologia

Directory of Open Access Journals (Sweden)

Jorge La Ferla

2011-01-01

Full Text Available Uma revisão crítica da obra do cineasta Robert Kramer, considerando as relações que propõe sua obra, a partir da utilização virtuosa de diversas máquinas audiovisuais em suas especificidades e combinações. O cinema, o vídeo, a televisão e as novas tecnologias constituem, em Kramer, processos de criação que dão origem a um trabalho expressivo com os dispositivos fotoquímicos, eletrônicos e digitais.

[Margaret Cavendish vs Robert Hooke: An impossible duel].

Science.gov (United States)

Aït-Touati, Frédérique

2016-12-01

In 1665, Robert Hooke published his major work in microscopy, Micrographia, a defense of experimental philosophy. The following year, Margaret Cavendish, Duchess of Newcastle, published at her own expense a treatise and a novel that undermined the basis of this new science. The dispute broke out at the initiative of the Duchess, in the context of a vast controversy about the legitimacy and the efficiency of optical instruments in natural philosophy. All the figures of the dual are used, except one: the counterattack. Cavendish, indeed, was alone on the battlefield. Is it possible to call a dual a battle with only one combatant? This particular case of dispute that stops owing to the shortage of combatants is the subject of this article.

Photon cascade luminescence from Pr3+ ions in LiPrP4O12 polyphosphate

International Nuclear Information System (INIS)

Shalapska, T; Stryganyuk, G; Romanyshyn, Yu; Demchenko, P; Voloshinovskii, A; Trots, D; Gektin, A; Dorenbos, P

2010-01-01

The spectral-kinetic properties of luminescence from LiY 1-x Pr x P 4 O 12 (x = 1, 0.1) phosphors are studied in the 10-300 K temperature range upon excitation within the UV-VUV spectral range. The luminescence observed for LiPrP 4 O 12 at low temperatures is attributed to both intra-configurational 4f 2 → 4f 2 and inter-configurational 4f5d → 4f 2 radiative transitions of Pr 3+ . The temperature dependence of emission and the decay kinetics of Pr 3+ luminescence from LiY 1-x Pr x P 4 O 12 (x = 1, 0.1) phosphors are explained by temperature stimulated transitions from the 1 S 0 to the Pr 3+ 4f5d state. At low temperatures, the energy potential barrier between the 1 S 0 and 4f5d states is 0.014 eV for LiPrP 4 O 12 . The spectral overlap of the 1 S 0 and 4f5d states of Pr 3+ in LiY 0.9 Pr 0.1 P 4 O 12 determines the luminescence properties in the entire temperature range studied.

USA mõtleja : vaid rikkus riiki koos ei hoia / Robert Putnam ; interv. Erkki Bahovski

Index Scriptorium Estoniae

Putnam, Robert

2006-01-01

USA Harvardi ülikooli politoloogiaprofessori Robert Putnami arvates on etniliselt mitmekesistes riikides ühtsustunde loomine raske, selle saavutamisele aitaksid kaasa ühiskonna pingevabam enesemääratlus ning paindlikumad töögraafikud naistele ühendamaks pere tööga. Lisa: Üksi või koos?

Empirical Asset Pricing: Eugene Fama, Lars Peter Hansen, and Robert Shiller

OpenAIRE

Campbell, John Y.

2016-01-01

The Nobel Memorial Prize in Economic Sciences for 2013 was awarded to Eugene Fama, Lars Peter Hansen, and Robert Shiller for their contributions to the empirical study of asset pricing. Some observers have found it hard to understand the common elements of the laureates research, preferring to highlight areas of disagreement among them. This paper argues that empirical asset pricing is a coherent enterprise, which owes much to the laureates seminal contributions, and that important themes in ...

Kolm vaadet Tallinna vanalinnale / Villem Tomiste, Martin Aunin, Robert Treufeldt ; intervjueerinud Ingrid Ruudi

Index Scriptorium Estoniae

Tomiste, Villem, 1975-

2009-01-01

Tallinna vanalinna ja kesklinna piiril asuv kvartal 57B, mis piirneb Aia, Vana-Viru, Inseneri tänava ja Mere Puiesteega, ajendas vanalinna hoonestuspõhimõtete ja tulevikulahenduste üle arutama arhitekte Villem Tomistet, Martin Auninit ning arhitektuuriajaloolast, ICOMOSi Eesti komitee esimeest Robert Treufeldti. Pikemalt korterelamust Aia 4/Vana-Viru 13, Aia 6 ja 8 detailplaneeringu eskiisist

More Misbehavior of Organisms: A Psi Chi Lecture by Marian and Robert Bailey

Science.gov (United States)

Bihm, Elson M.; Gillaspy, J. Arthur, Jr.; Abbott, Hannah J.; Lammers, William J.

2010-01-01

In 1992, Dr. Marian Breland Bailey, assisted by her husband Robert E. Bailey, gave the following presentation at the Psi Chi Banquet of the University of Central Arkansas. She and her first husband, Keller Breland, were students of B. F. Skinner and established Animal Behavior Enterprises (ABE) in 1947 and the IQ Zoo in 1955. Unknown to many…

Robert Aymar awarded Global Energy prize

CERN Multimedia

2006-01-01

CERN Director-General Robert Aymar was recently named one of three laureates of the 2006 Global Energy International Prize for 'the development of scientific and engineering foundation for the ITER project.' ITER is an experiment planned to be built in Europe at Cadarache (South of France) and designed to show the scientific and technological feasibility of a full-scale fusion power reactor. The other two laureates, who worked with Aymar on the project, are former President of the ITER Council, Russian Academician Evgeny Velikhov, and Japan's Dr Masaji Yoshikawa, ITER's former Vice President. Aymar headed ITER from 1994 to 2003. 'This prize is not only a great honour for me and my friends and colleagues of many years at ITER, Evgeny Velikhov and Masaji Yoshikawa,' Aymar said. 'It is above all a recognition of the effort of all those who have been involved with the ITER project and worked over the years to ensure the first step in proving that fusion will provide a new sustainable energy source for the plane...

PrEP (Pre-Exposure Prophylaxis) 101

Science.gov (United States)

... than 70%. Your risk of getting HIV from sex can be even lower if you combine PrEP with condoms and other prevention methods. Download PrEP 101 Consumer Info Sheet Vital Signs Fact Sheet on Daily Pill Can Prevent HIV (PrEP) Expand All Collapse All Video Introductions to PrEP What is PrEP? A Brief ...

PrP Conformational Transitions Alter Species Preference of a PrP-specific antibody

NARCIS (Netherlands)

Zou, W.Q.; Langeveld, J.P.M.; Xiao, X.; Chen, S.; McGeer, P.L.; Yuan, J.; Payne, M.C.; Kang, H.E.; McGeehan, J.M.; Sy, M.S.; Greenspan, N.S.; Kaplan, D.; Wang, G.X.; Parchi, P.; Hoover, E.A.; Kneale, G.; Telling, G.; Surewicz, W.; Kong, Q.; Guo, J.

2010-01-01

The epitope of the 3F4 antibody most commonly used in human prion disease diagnosis is believed to consist of residues Met-Lys-His-Met (MKHM) corresponding to human PrP-(109–112). This assumption is based mainly on the observation that 3F4 reacts with human and hamster PrP but not with PrP from

PrP expression, PrPSc accumulation and innervation of splenic compartments in sheep experimentally infected with scrapie.

Directory of Open Access Journals (Sweden)

Randi Sørby

Full Text Available BACKGROUND: In prion disease, the peripheral expression of PrP(C is necessary for the transfer of infectivity to the central nervous system. The spleen is involved in neuroinvasion and neural dissemination in prion diseases but the nature of this involvement is not known. The present study undertook the investigation of the spatial relationship between sites of PrP(Sc accumulation, localisation of nerve fibres and PrP(C expression in the tissue compartments of the spleen of scrapie-inoculated and control sheep. METHODOLOGY/PRINCIPAL FINDINGS: Laser microdissection and quantitative PCR were used to determine PrP mRNA levels and results were compared with immunohistochemical protocols to distinguish PrP(C and PrP(Sc in tissue compartments of the spleen. In sheep experimentally infected with scrapie, the major sites of accumulation of PrP(Sc in the spleen, namely the lymphoid nodules and the marginal zone, expressed low levels of PrP mRNA. Double immunohistochemical labelling for PrP(Sc and the pan-nerve fibre marker, PGP, was used to evaluate the density of innervation of splenic tissue compartments and the intimacy of association between PrP(Sc and nerves. Some nerve fibres were observed to accompany blood vessels into the PrP(Sc-laden germinal centres. However, the close association between nerves and PrP(Sc was most apparent in the marginal zone. Other sites of close association were adjacent to the wall of the central artery of PALS and the outer rim of germinal centres. CONCLUSIONS/SIGNIFICANCE: The findings suggest that the degree of PrP(Sc accumulation does not depend on the expression level of PrP(C. Though several splenic compartments may contribute to neuroinvasion, the marginal zone may play a central role in being the compartment with most apparent association between nerves and PrP(Sc.

Teorizando o mundo contemporâneo: Robert Brenner; Giovanni Arrighi; David Harvey

Directory of Open Access Journals (Sweden)

Moishe Postone

2008-07-01

Full Text Available O artigo busca apreender as profundas transformações sociais, políticas, econômicas e culturais que marcaram as três últimas décadas, em contraste com o período de prosperidade subseqüente à Segunda Guerra Mundial. Para tanto, o autor analisa criticamente três obras específicas que abordam o período: "The economics of global turbulence", de Robert Brenner, O longo século XX, de Giovanni Arrighi, e A condição pós-moderna, de David Harvey. O procedimento metateórico adotado permite apontar os requisitos de uma teoria crítica adequada ao capitalismo contemporâneo.The article aims to apprehend the deep social, political, economic and cultural transformations that characterized the three last decades, in contrast with the prosperity period following the Second World War. Therefore, the author critically analyses three specific works that deal with that period: "The economics of global turbulence", by Robert Brenner, The long Twentieth Century, by Giovanni Arrighi, and The conditions of postmodernity, by David Haravey. The metatheoric procedure adopted allows him to indicate the requisites of an adequate critical theory of contemporary capitalism.

Robert Bartini and His Contribution to the Development of Transport and Aviation

Science.gov (United States)

Težak, Sergej

2017-10-01

After the First World War, the young Soviet Union (USSR) desperately needed new engineers and scientists who would provide the new country with development of modern industry and transportation. At that time, Western European countries had knowledge and experience, especially in the field of aviation. One of the young engineers was Robert Bartini, who was educated in Austria-Hungary and Italy, and graduated from Milan Polytechnic Institute. In 1923, he fled Italy to escape Fascists and emigrated in Soviet Union. This article is a brief description of aircraft designer Robert Bartini and his role in the development of the military, passenger and transport aviation. In addition, it presents his vision of the intercontinental and continental high-speed transport, which was his focus in the last years of his work and creation. He worked as a researcher and expert in the former Soviet Union, therefore, more detailed and relevant information on his work has been revealed to the public in recent years. In Russia, he is very popular as a researcher and developer. There are many books about him in Russian and Italian language, but not in English. Thus, his work is still quite unknown in the West. He was born in Kanjiza (today Serbia) in 1897, and spent his youth in Fiume (Rijeka, today Croatia).

Los orígenes del grial en la literatura medieval: de Chrétien de Troyes a Robert de Boron

Directory of Open Access Journals (Sweden)

Mario Martín Botero

2010-12-01

Full Text Available Este artículo muestra el origen literario del tema del Grial en la literatura medieval francesa, abordando dos textos esenciales para el surgimiento y consolidación de la “literatura del Grial”: Le Conte du Graal de Chrétien de Troyes y Le Roman de l’Estoire dou Graal de Robert de Boron. Los autores de estas obras establecen las bases para el desarrollo de toda una temática que gira alrededor del Grial a partir del siglo XII hasta nuestros días. El artículo muestra cómo de un objeto apenas sagrado en el texto de Chrétien de Troyes se pasa a una reliquia de la sangre de Cristo en la versión de Robert de Boron.This paper studies the literary origin of the Grail legend in medieval French literature, taking into account two important romances: Le Conte du Graal by Chrétien de Troyes and Le Roman de l’Estoire dou Graal by Robert de Boron. In these two texts the authors established the basis for the development of a new subject matter around the mysterious object called “Grail” from the Middle Ages to the present times. It will also be shown how an object, not totally sacred in Chrétien de Troyes, becomes a relic related with Jesus’s blood in Robert de Boron.

The Impossibility of Maintaining the Minimal State of Robert Nozick

Directory of Open Access Journals (Sweden)

Virgílio Queiroz de Paula

2015-12-01

Full Text Available In this paper we analyze how Robert Nozicks minimal state proposed would invariably end, unless its members were coerced by the central government to contribute to its maintenance. And, in this case, rights and freedom protected under the philosophers state would obviously be violated. We also analyze the flaws in Nozicks model through economic bias in order to show - through game theory and logic of collective action  how an organization that provides nonexclusive public goods is vulnerable to the action of free-riders, thus increasing the costs of its performance, and decreasing motivation for its existence.

ESO PR Highlights in 2006

Science.gov (United States)

2007-01-01

Last year proved to be another exceptional year for the European organisation for ground-based astronomy. ESO should begin the New Year with two new member states: Spain (PR 05/06) and the Czech Republic (PR 52/06). ESO PR Highlights 2006 2006 was a year of renovation and revolution in the world of planets. A new Earth-like exoplanet has been discovered (PR 03/06) using a network of telescopes from all over the world (including the Danish 1.54-m one at ESO La Silla). It is not the only child of this fruitful year: thanks to the combined use of ESO's Very Large Telescope (VLT) and La Silla instruments, a surprising system of twin giant exoplanets was found (PR 29/06), and a trio of Neptune-like planets hosted by a nearby star were identified (PR 18/06). These results open new perspectives on the search for habitable zones and on the understanding of the mechanism of planet formation. The VISIR instrument on the VLT has been providing unique information to answer this last question, by supplying a high resolution view of a planet-forming disc (PR 36/06). There are not only new members in the planets' register: during the General Assembly of the International Astronomical Union held in Prague (Czech Republic), it was decided that Pluto is not a planet anymore but a 'dwarf planet'. Whatever its status, Pluto still has a satellite, Charon, whose radius and density have been measured more accurately by observing a rare occultation from different sites, including Cerro Paranal (PR 02/06). The scientific community dedicated 2006 to the great physicist James Clerk Maxwell (it was the 175th anniversary of the birth): without his electromagnetic theory of light, none of the astonishing discoveries of modern physics could have been achieved. Nowadays we can look at distant galaxies in great detail: the GIRAFFE spectrograph on the VLT revealed that galaxies 6 billion years ago had the same amount of dark matter relative to stars than nowadays (PR 10/06), while SINFONI gave an

Cancer de la próstata

OpenAIRE

Mendoza, Lupi Alejandro; Fundación Valle de Lili; Gutierrez, María Carolina; López Cardona, Arturo

1997-01-01

¿Qué es la próstata?/¿Qué es la hiperplasia benigna de próstata?/El cáncer de próstata/¿Se hereda el cáncer de próstata?/¿Cómo se presenta y hacia donde se disemina el cáncer de próstata?/¿Cómo de descubre el cáncer de próstata?/¿Qué estudia la ultrasonografía transrectal o ecografía a través de recto?/¿Cómo se analizan los niveles de PSA?/¿Cómo se clasifica el cáncer de próstata?¿Cómo se determina la terapia más adecuada para un cáncer de próstata?/¿Cuáles son las opciones de tratamiento par...

Taasavatud mälestuskivi väärtustab Robert von Tolli tegemisi / Külli Kriis

Index Scriptorium Estoniae

Kriis, Külli, 1961-

2007-01-01

26. juulil taasavati Kukruse külas mälestuskivi, mille Kukruse mõisa omanik Robert von Toll sinna aastal 1866 pargi rajamise puhul püstitas. Ilmunud ka: Severnoje Poberezhje, 28. juuli 2007 (Vnov ustanovlennõi kamen - dan pamjati dejatelnosti Roberta fon Tollja)

Robert Williams Wood: pioneer of invisible light.

Science.gov (United States)

Sharma, Shruti; Sharma, Amit

2016-03-01

The Wood's lamp aids in the diagnosis of multiple infectious, inflammatory and neoplastic dermatologic conditions. Although the Wood's lamp has many applications, which have improved both the diagnosis and management of disease, the man credited for its invention is relatively unknown in medicine. Robert Williams Wood, a prominent physicist of the early 20th century, is credited for the invention of the Wood's lamp. Wood was the father of infrared and ultraviolet photography and made significant contributions to other areas in optics and spectroscopy. Wood's work encompassed the formative years of American Physics; he published over 200 original papers over his lifetime. A few years after the invention of the Wood's lamp for ultraviolet photography, physicians in Europe adopted the Wood's lamp for dermatologic applications. Wood's lamp remains popular in clinics globally, given its ease of use and ability to improve diagnostic precision. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Production of no-carrier-added 139Pr via precursor decay in the proton bombardment of natPr

International Nuclear Information System (INIS)

Steyn, G.F.; Vermeulen, C.; Nortier, F.M.; Szelecsenyi, F.; Kovacs, Z.; Qaim, S.M.

2006-01-01

Excitation functions and production rates are presented for various Pr and Nd radionuclides formed in the bombardment of Pr with protons, from their respective thresholds up to 100 MeV. The indirect production route 141 Pr(p, 3n) 139m Nd → 139 Pr is investigated as an alternative to the direct production route 140 Ce(p, 2n) 139 Pr for producing no-carrier-added 139 Pr of high radionuclidic purity. The simultaneous production of 139 Pr and 140 Nd using Pr as target is investigated. The advantages and disadvantages of both production routes are discussed. Experimental thick-target production rates are presented for selected Pr radionuclides formed in the bombardment of nat Ce with protons at incident energies of 20, 26 and 32 MeV. All the experimental excitation functions obtained in this work are compared with theoretical predictions by means of the geometry-dependent hybrid (GDH) model as implemented in the code ALICE-IPPE. The results of this work are also compared with previous literature experimental data, if available

Erfolgsfaktoren unternehmerischer Krisen-PR

OpenAIRE

Scharr, Florian

2006-01-01

Ob "Peanuts", "Elchtest" oder "Hoechst-Störfall" - bei diesen bekannten Öffentlichkeitskrisen der letzten Jahre rief die mangelhafte Krisen-PR der betroffenen Unternehmen bei Medien und Bevölkerung mehr Empörung hervor als die originären Auslöser und potenzierte so den entstandenen Vertrauensverlust. Auch die sich gerade erst entwickelnde PR-Forschung bietet noch keine konkrete Hilfestellung zur Gestaltung von Krisen-PR. Mit dem bedeutenden Diskurs- und dadurch Realitätsgestaltungsmittel Pres...

Salvinorin A analogues PR-37 and PR-38 attenuate compound 48/80-induced itch responses in mice.

Science.gov (United States)

Salaga, M; Polepally, P R; Zielinska, M; Marynowski, M; Fabisiak, A; Murawska, N; Sobczak, K; Sacharczuk, M; Do Rego, J C; Roth, B L; Zjawiony, J K; Fichna, J

2015-09-01

The opioid system plays a crucial role in several physiological processes in the CNS and in the periphery. It has also been shown that selective opioid receptor agonists exert potent inhibitory action on pruritus and pain. In this study we examined whether two analogues of Salvinorin A, PR-37 and PR-38, exhibit antipruritic properties in mice. To examine the antiscratch effect of PR-37 and PR-38 we used a mouse model of compound 48/80-induced pruritus. In order to elucidate the mechanism of action of tested compounds, specific antagonists of opioid and cannabinoid receptors were used. The effect of PR-37 on the CNS was assessed by measuring motor parameters and exploratory behaviours in mice. PR-37 and PR-38, jnjected s.c., significantly reduced the number of compound 48/80-induced scratching behaviours in mice in a dose- and time-dependent manner. PR-38 was also active when orally administered. The antiscratch activity of PR-37 was blocked by the selective κ opioid receptor antagonist, nor-binaltorphimine, and that of PR-38 by the selective μ opioid receptor antagonist, β-funaltrexamine. In conclusion, a novel framework for the development of new antipruritic drugs derived from salvinorin A has been validated. © 2015 The British Pharmacological Society.

Reproduction of the San Joaquin kit fox (Vulpes velox macrotis) on Camp Roberts Army National Guard Training Site, California

International Nuclear Information System (INIS)

Spencer, K.A.; Berry, W.H.; Standley, W.G.; O'Farrell, T.P.

1992-09-01

The reproduction of a San Joaquin kit fox population (Vulpes velox macrotis) was investigated at Camp Roberts Army National Guard Training Site, California, from November 1988 through September 1991. Of 38 vixens radiocollared prior to parturition, 12 (32%) were successful in raising pups from conception to the point where pups were observed above ground. No yearling vixens were known tb be reproductively active. The mean litter size during 1989 - 1991 was 3.0 (n = 21, SE = 0.28) and ranged from one to six pups. Both the proportion of vixens successfully raising pups and the mean litter size observed at Camp Roberts during this study were lower than those reported at other locations. Sex ratios of kit fox pups were male biased two of the three years, but did not differ statistically from 1:1 throughout the study. Whelping was estimated to occur between February 15 and March 5. Results of this study support previous reports that kit foxes are primarily monogamous, although one case of polygamy may have occurred. Both the proportion of dispersing radiocollared juveniles (26%) and the mean dispersal distance (5.9 km) of juveniles at Camp Roberts appeared low compared to other locations

Robert Michels y las teorías elitista-competitivas de la democracia

OpenAIRE

Caparrós Valderrama, Rafael

2008-01-01

Robert Michel's main work is "Political parties. A Sociological Study on the Oligarchical Tendencies of Modern Democracy", issued in 1911, which is an analysis on the internal organization evolving dynamics of the German Social-Democrat Party (SDP), to which the author was intensely attached for several years. The aim of this essay is hte sociological study of the leadership emergence, power psicology and the organizational oligarchical tendencies. In it all argumentation can be found on the ...

O EPÍLOGO DA TEORIA DOS DIREITOS FUNDAMENTAIS EM ROBERT ALEXY

OpenAIRE

Araújo Silveira, Whenry Hawlysson; Bruno da Silva, Alexandre Antônio

2014-01-01

Com o advento da Constituição Federal de 1988, foram implementados novos conceitos concernentes à Teoria do Direito por consequência de um fenômeno mundialmente conhecido como Neoconstitucionalismo. Uma destas mutações se dá por seu caráter axiológico e diz respeito à teoria dos direitos fundamentais. Robert Alexy inova seu pensamento a afirmar que o conflito entre direitos e garantias fundamentais deve ser resolvido pelo instituto da ponderação e afirma que esse instituto não se trata de um ...

Robert Hare's Theory of Galvanism: A Study of Heat and Electricity in Early Nineteenth-Century American Chemistry.

Science.gov (United States)

Fisher, Amy

2018-04-09

As a professor of chemistry at the University of Pennsylvania, Robert Hare actively shaped early American science. He participated in a large network of scholars, including Joseph Henry, François Arago, and Jacob Berzelius, and experimented with and wrote extensively about electricity and its associated chemical and thermal phenomena. In the early nineteenth century, prominent chemists such as Berzelius and Humphry Davy proclaimed that a revolution had occurred in chemistry through electrical research. Examining Robert Hare's contributions to this discourse, this paper analyzes how Hare's study of electricity and the caloric theory of heat led him to propose a new theory of galvanism. It also examines the reception of Hare's work in America and Great Britain, highlighting the contributions of early American chemists to the development of electrochemistry.

Discussing compliance. Summary report from discussions with Robert Bernero and Chris Whipple regarding compliance with the Swedish HLW Regulations from meetings in Stockholm May 3 and 4, 1999

Energy Technology Data Exchange (ETDEWEB)

Jensen, Mikael

1999-06-01

Summary report from discussions with Robert Bernero and Chris Whipple regarding compliance with the Swedish HLW Regulations from meetings in Stockholm. The report also contains bibliographical information and preliminary observations made by Robert Bernero and Chris Whipple.

Discussing compliance. Summary report from discussions with Robert Bernero and Chris Whipple regarding compliance with the Swedish HLW Regulations from meetings in Stockholm May 3 and 4, 1999

International Nuclear Information System (INIS)

Jensen, Mikael

1999-06-01

Summary report from discussions with Robert Bernero and Chris Whipple regarding compliance with the Swedish HLW Regulations from meetings in Stockholm. The report also contains bibliographical information and preliminary observations made by Robert Bernero and Chris Whipple

Sir Robert Ball: Victorian Astronomer and Lecturer par excellence

Science.gov (United States)

Jones, R. I. G.

2005-12-01

Between 1875 and 1910 Sir Robert Stawell Ball gave an estimated 2,500 lectures in towns and cities all over the British Isles and abroad. This paper traces his lecturing career from its beginnings in Ireland to the triumphs of the Royal Institution, and on lecture tours in the United States of America. After a period in mathematics and mechanics, he became a populariser of science, especially astronomy, and found fame and fortune among the working classes and the aristocracy. What motivated him to tireless travels is uncertain, but it might have been that it was rewarding, financially and to his reputation. Whatever his motives, contemporary accounts are clear that BallÕs lectures were extremely popular and well-received.

CBO Testimony: Statement of Robert F. Hale, Assistant Director, National Security Division, Congressional Budget Office

National Research Council Canada - National Science Library

Hale, Robert F

1991-01-01

.... This testimony, by Robert F. Hale, Congressional Budget Office, covers the following topics: Socioeconomic Backgrounds of Enlisted Recruits, Racial Mix of Enlisted Recruits, Shifts in Recruiting during the 1980s, Altering the Composition of the Military: Reserve Mobilization and Conscription, and Should the Social Composition of the Military be a Concern?

Infectivity-associated PrP(Sc) and disease duration-associated PrP(Sc) of mouse BSE prions.

Science.gov (United States)

Miyazawa, Kohtaro; Okada, Hiroyuki; Masujin, Kentaro; Iwamaru, Yoshifumi; Yokoyama, Takashi

2015-01-01

Disease-related prion protein (PrP(Sc)), which is a structural isoform of the host-encoded cellular prion protein, is thought to be a causative agent of transmissible spongiform encephalopathies. However, the specific role of PrP(Sc) in prion pathogenesis and its relationship to infectivity remain controversial. A time-course study of prion-affected mice was conducted, which showed that the prion infectivity was not simply proportional to the amount of PrP(Sc) in the brain. Centrifugation (20,000 ×g) of the brain homogenate showed that most of the PrP(Sc) was precipitated into the pellet, and the supernatant contained only a slight amount of PrP(Sc). Interestingly, mice inoculated with the obtained supernatant showed incubation periods that were approximately 15 d longer than those of mice inoculated with the crude homogenate even though both inocula contained almost the same infectivity. Our results suggest that a small population of fine PrP(Sc) may be responsible for prion infectivity and that large, aggregated PrP(Sc) may contribute to determining prion disease duration.

Thermodynamic assessment of the Pr-Zn binary system

International Nuclear Information System (INIS)

Huang, X.M.; Liu, L.B.; Zhang, L.G.; Jia, B.R.; Jin, Z.P.; Zheng, F.

2008-01-01

On the basis of available experimental data of phase diagram and thermodynamic properties, the Pr-Zn binary system has been optimized using the CALPHAD approach. The phases, including liquid and bcc A 2(βPr) were treated as substitutional solutions, while the intermetallic compounds, including PrZn, PrZn 2 , PrZn 3 , Pr 3 Zn 11 , Pr 13 Zn 58 , Pr 3 Zn 22 , Pr 2 Zn 17 and PrZn 11 were modeled as stoichiometric compounds. As the result of optimization, a set of self-consistent thermodynamic parameters has been obtained, which can be used to reproduce the reported experimental data

Mechanistic prospective for human PrPC conversion to PrPSc: Molecular dynamic insights

OpenAIRE

Nooshin Azari; Mohammad Reza Dayer; Nematollah Razmi; Mohammad Saaid Dayer

2013-01-01

PrPC conversion to PrPSc isoform is the main known cause for prion diseases including Crutzfeldt-Jakob, Gerstmann-Sträussler-Sheinker syndrome and fatal familial insomnia in human. The precise mechanism underling this conversion is yet to be well understood. In the present work, using the coordinate file of PrPC (available on the Protein Data Bank) as a starting structure, separate molecular dynamic simulations were carried out at neutral and acidic pH in an explicit water box at 37°C and 1 ...

Piperazine derivatives inhibit PrP/PrP(res) propagation in vitro and in vivo.

Science.gov (United States)

Leidel, Fabienne; Eiden, Martin; Geissen, Markus; Hirschberger, Thomas; Tavan, Paul; Giese, Armin; Kretzschmar, Hans A; Schätzl, Hermann; Groschup, Martin H

2014-02-28

Prion diseases are fatal neurodegenerative disorders, which are not curable and no effective treatment exists so far. The major neuropathological change in diseased brains is the conversion of the normal cellular form of the prion protein PrPc(C) into a disease-associated isoform PrP(Sc). PrP(Sc) accumulates into multimeres and fibrillar aggregates, which leads to the formation of amyloid plaques. Increasing evidence indicates a fundamental role of PrP(Sc) species and its aggregation in the pathogenesis of prion diseases, which initiates the pathological cascade and leads to neurodegeneration accompanied by spongiform changes. In search of compounds that have the potential to interfere with PrP(Sc) formation and propagation, we used a cell based assay for the screening of potential aggregation inhibitors. The assay deals with a permanently prion infected cell line that was adapted for a high-throughput screening of a compound library composed of 10,000 compounds (DIVERset 2, ChemBridge). We could detect six different classes of highly potent inhibitors of PrP(Sc) propagation in vitro and identified piperazine derivatives as a new inhibitory lead structure, which increased incubation time of scrapie infected mice. Copyright © 2014 Elsevier Inc. All rights reserved.

Identification and expression analysis of a pathogenresponsive PR ...

African Journals Online (AJOL)

related (PR) proteins. PR-1 genes represent the first identified PR gene family. Most members of PR-1 gene family are not inducible by pathogen attacks. In this study, we identified a pathogen-responsive PR-1 gene designated as VqPR-1 ...

PR Crisis Melalui Media Sosial

Directory of Open Access Journals (Sweden)

Gladys Carlina

2017-07-01

Full Text Available The background of this research is communication, new media, PR and PR Crisis. Fourth of this background has a close relationship, starting from communication, human in everyday life would require communication to receive and convey information, human can not be released from human life. The advancement of the times and the development of technology, causing people to communicate easily and the development of this era caused a new challenge for the PR and PR Crisis of a company, they should be able to maintain a positive image of the company in the minds of people. In this study using descriptive qualitative methodology, it contains many writings and drawings compared to the numbers. The purpose of this research is to know the strategy used by Pizza Hut in dealing with the issue of expired food. Penelitin results, social media is very positive impact on Pizza Hut in the recovery of food issues expired. The strategy used by the Pizza Hut Crisis PR is to utilize social media. Visible from the issue of expired food that disappeared in public and Pizza Hut restaurant until now crowded visited. Latar belakang dari penelitian ini yaitu komunikasi, media baru, PR dan PR Krisis. Keempat dari latar belakang ini mempunyai hubungan yang erat, dimulai dari komunikasi, manusia di dalam kehidupan sehari-hari tentunya memerlukan komunikasi untuk menerima dan menyampaikan informasi, manusia tidak bisa dilepaskan dari kehidupan manusia. Majunya perkembangan zaman dan perkembangan teknologi, menyebabkan manusia melakukan komunikasi dengan mudah dan perkembangan zaman ini menyebabkan adanya tantangan baru bagi para PR dan PR Krisis sebuah perusahaan, mereka harus bisa mempertahankan citra positif perusahaan di benak masyarakat. Dalam penelitian ini menggunakan metodologi kualitatif deksriptif, memuat banyak tulisan dan gambar dibandingkan angka-angka. Tujuan dari penelitian ini untuk mengetahui strategi yang digunakan oleh Pizza Hut dalam menangani isu makanan

Studies in the Crystalline Electric Field in Pr2 Al and Pr Al by the Inelastic Neutron Scattering Method

International Nuclear Information System (INIS)

Slisenko, V.I.; Ivanitskij, P.G.; Vasil'kevich, A.A.; Krotenko, V.T.; Majstrenko, A.N.

1993-01-01

Results of inelastic neutron scattering in polycrystalline Pr 2 Al and Pr Al are reported. The parameters of the crystal field Hamiltonian for the orthorhombic point symmetry of the Pr 3+ ions in Pr 2 Al and Pr Al are derived from neutron spectra. Using These parameters the magnetic contribution to the specific heat is calculated

Science, Beliefs and Knowledge: A Personal Reflection on Robert J. Aumann’s Approach

OpenAIRE

Gil Kalai

2006-01-01

On the occasion of Robert J. Aumann's being awarded the 2005 Nobel Prize in Economics, this paper gives a personal view on some of Aumann's contributions, and primarily on his approach to foundational issues in game theory, economics, and science as a whole. It is based on numerous discussions and e-mail exchanges we had in the 1990's, dealing with various scientific and political matters, including our long debate on the ``Bible Code'' controversy.

Tips for the PR Chairman for Education Associations. PR Bookshelf No. 2.

Science.gov (United States)

National Education Association, Washington, DC.

This booklet is intended to aid leaders of local education associations in developing a continuing public relations (PR) program aimed at establishing and maintaining a favorable public image for teachers. Although it offers useful guidelines for developing a PR program, the booklet does not contain lists of specific things to do. Instead, it…

75 FR 44847 - Proposed Collection; Comment Request for Forms 943, 943-PR, 943-A, and 943A-PR

Science.gov (United States)

2010-07-29

... 943, 943-PR, 943- A, and 943A-PR AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and... comments concerning Forms 943, Employer's Annual Tax Return for Agricultural Employees, 943-PR, Planilla..., Agricultural Employer's Record of Federal Tax Liability, and 943A-PR, Registro De La Obligacion Contributiva...

Small protease sensitive oligomers of PrPSc in distinct human prions determine conversion rate of PrP(C.

Directory of Open Access Journals (Sweden)

Chae Kim

Full Text Available The mammalian prions replicate by converting cellular prion protein (PrP(C into pathogenic conformational isoform (PrP(Sc. Variations in prions, which cause different disease phenotypes, are referred to as strains. The mechanism of high-fidelity replication of prion strains in the absence of nucleic acid remains unsolved. We investigated the impact of different conformational characteristics of PrP(Sc on conversion of PrP(C in vitro using PrP(Sc seeds from the most frequent human prion disease worldwide, the Creutzfeldt-Jakob disease (sCJD. The conversion potency of a broad spectrum of distinct sCJD prions was governed by the level, conformation, and stability of small oligomers of the protease-sensitive (s PrP(Sc. The smallest most potent prions present in sCJD brains were composed only of∼20 monomers of PrP(Sc. The tight correlation between conversion potency of small oligomers of human sPrP(Sc observed in vitro and duration of the disease suggests that sPrP(Sc conformers are an important determinant of prion strain characteristics that control the progression rate of the disease.

Modification of Roberts' Theory for Rocket Exhaust Plumes Eroding Lunar Soil

Science.gov (United States)

Metzger, Philip T.; Lane, John E.; Immer, Christopher D.

2008-01-01

Roberts' model of lunar soil erosion beneath a landing rocket has been updated in several ways to predict the effects of future lunar landings. The model predicts, among other things, the number of divots that would result on surrounding hardware due to the impact of high velocity particulates, the amount and depth of surface material removed, the volume of ejected soil, its velocity, and the distance the particles travel on the Moon. The results are compared against measured results from the Apollo program and predictions are made for mitigating the spray around a future lunar outpost.

Robert Molesworth's An Account of Denmark as it was in 1692

DEFF Research Database (Denmark)

Olden-Jørgensen, Sebastian

2008-01-01

Robert Moleswort's An Account of Denmark as it was in 1692 is a violent political pamphlet in the early British Whig-tradition aimed at underscoring republican values by pointing to the dreadful example of Danish Absolutist slavery. It was a bestseller on an international scale. In his book...... of these was Ludvig Holberg's Description of Denmark and Norway (1729) which counters Molesworth on the basis of history and natural law - and in a witty style. Thus the republican manifesto of Molesworth became instrumental in shaping the political outlook and language of the very moderate, loyal and anything...

Justice, Integrity and Fairness: Relevant Questions About Robert Nozick Political Theory

Directory of Open Access Journals (Sweden)

Carlos Fernando Cruz da Silva

2016-11-01

Full Text Available The present work develops and analysis about Robert Nozick political theory based in thesis defended by Ronald Dworkin. The central objective of this paper is to investigate the validity or the invalidity of the justice principles proposed by Nozick under the integrity theory. The methodology utilized to construct the definitive hypothesis was based, initially, in a theoretical search, developed through of an bibliographical lifting of the principal involved authors texts. After the survey, a descriptive analysis of the texts was executed and, then, was executed and critical analysis. At the end, an definitive proposal was constructed with an deductive reasoning.

78 FR 47051 - Proposed Collection; Comment Request for Forms 943, 943-PR, 943-A, and 943A-PR

Science.gov (United States)

2013-08-02

... 943, 943-PR, 943- A, and 943A-PR AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and..., 943-PR, Planilla Para La Declarcion Anual De La Contribucion Federal Del Patrono De Empleados Agricolas, 943-A, Agricultural Employer's Record of Federal Tax Liability, and 943A-PR, Registro De La...

Die prädikatsergänzung (das prädikatsattribut in der Slovenischen Syntax

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Breda Pogorelec

1972-12-01

Full Text Available In der vorliegenden Abhandlung wird die erwähnte Problematik in der slovenischen grammatischen -Überlieferung behandelt und mit interessanten Ergebnissen vor allem der tschechischen Sprachtheorie ergänzt, es wird der Terminus Prädikatsergänzung gegenüber dem Terminus Prädikatsattribut begründet; auf dieser Grundlage werden auch die bisher behandelten Arten von Prädikatsergänzungen mit neuen ergänzt. Dabei findet wenn nur möglich das einfache Transformationsverfahren Verwendung, das die Veranschaulichung der stufenweisen Determinierung durch das Prädikatsattribut ermöglicht. Das Material entstammt vorwiegend der Sprache der Kunst, der Grund dafür ist vor allem in der Tatsache zu suchen, daß in dieser Sprache dieser Form die Rolle eines natürlichen Kondensators zufällt, weshalb sie verhältnismäßig häufig vorkommt. Die Abhandlung befaßt sich eingehender auch mit dem Problem der Wortfolge und berührt auch die graphische Darstellung der bei der Prädikatsergänzung üblichen Pausen.

Bolonia y la buena práctica de las prácticas

OpenAIRE

García Delgado, Javier

2016-01-01

A propósito de la implantación del controvertido “plan Bolonia” se están difundiendo algunas ideas negativas en relación con una supuesta “mercantilización” de la universidad, algunas relacionadas con la explotación de los estudiantes a través de las prácticas en empresas, o prácticas externas, sobre las cuales se reflexiona en este artículo. ¿Qué hemos aprendido tras las ya casi tres décadas transcurridas desde la promulgación del decreto del año 81 que autorizaba este tipo de prácticas? Ese...

Contemporary Hegelian Scholarship: Robert Stern’s Holistic Reading of Hegel

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Paniel Reyes Cardenas

2015-12-01

Full Text Available This is a monographic presentation in which the author depicts the guidelines of Professor Robert Stern’s interpretation of Hegelian Metaphysics by emphasizing in its characteristic holistic reading. The proposal is that some key fundamental topics of Hegelian scholarship will emerge with a clarified understanding after this reading: the concept of Truth and absolute knowledge are reassessed by showing the necessary connection of Epistemology and Metaphysics in Hegel. Hegelian Metaphysics, accordingly, appears ultimately as the principle for a reading of Hegel’s entire philosophy and illuminates its nature of general metaphysical inquiry. Finally, this reading allows drawing on the connection of Hegel’s Idealism with the Pragmatist tradition initiated by Peirce.

PrPST, a Soluble, Protease Resistant and Truncated PrP Form Features in the Pathogenesis of a Genetic Prion Disease

Science.gov (United States)

Frid, Kati; Binyamin, Orli; Gabizon, Ruth

2013-01-01

While the conversion of PrPC into PrPSc in the transmissible form of prion disease requires a preexisting PrPSc seed, in genetic prion disease accumulation of disease related PrP could be associated with biochemical and metabolic modifications resulting from the designated PrP mutation. To investigate this possibility, we looked into the time related changes of PrP proteins in the brains of TgMHu2ME199K/wt mice, a line modeling for heterozygous genetic prion disease linked to the E200K PrP mutation. We found that while oligomeric entities of mutant E199KPrP exist at all ages, aggregates of wt PrP in the same brains presented only in advanced disease, indicating a late onset conversion process. We also show that most PK resistant PrP in TgMHu2ME199K mice is soluble and truncated (PrPST), a pathogenic form never before associated with prion disease. We next looked into brain samples from E200K patients and found that both PK resistant PrPs, PrPST as in TgMHu2ME199K mice, and “classical” PrPSc as in infectious prion diseases, coincide in the patient's post mortem brains. We hypothesize that aberrant metabolism of mutant PrPs may result in the formation of previously unknown forms of the prion protein and that these may be central for the fatal outcome of the genetic prion condition. PMID:23922744

Fermilab's Helen Edwards receives prestigious 2003 Robert R. Wilson prize from the American Physical Society

CERN Multimedia

2002-01-01

Helen Edwards has been awarded the 2003 Robert R. Wilson prize. She was cited for "her pivotal achievement and critical contribution as the leader in the design, construction, commissioning and operation of the Tevatron, and for her continued contributions to the development of high gradient superconducting linear accelerators as well as bright and intense electron sources." (1/2 page).

HIV-negative male couples' attitudes about pre-exposure prophylaxis (PrEP) and using PrEP with a sexual agreement.

Science.gov (United States)

Mitchell, Jason W; Lee, Ji-Young; Woodyatt, Cory; Bauermeister, José; Sullivan, Patrick; Stephenson, Rob

2016-08-01

One efficacious strategy to help prevent HIV is oral pre-exposure prophylaxis (PrEP), a daily regimen of antiretroviral treatment taken by HIV-negative individuals. Two of the recommendations of Centers for Disease Control and Prevention (CDC) guidelines for PrEP pertain to being in a relationship (i.e., male couples). Despite the recognition of how primary partners in male couples' relationships shape HIV risk and CDC's PrEP guidelines, there is a paucity of data that examine HIV-negative male couples' attitudes toward PrEP use and using PrEP with a sexual agreement. A sexual agreement is an explicit agreement made between two individuals about what sex and other related behaviors may occur within and outside of their relationship. In this qualitative study, we examine HIV-negative male couples' attitudes toward PrEP use and whether they thought PrEP could be integrated into a sexual agreement. Data for this study are drawn from couple-level interviews conducted in 2014 with 29 HIV-negative male couples who had a sexual agreement and were from Atlanta or Detroit. Both passive (e.g., flyers) and active (e.g., targeted Facebook advertisements) recruitment methods were used; the sample was stratified by agreement type. Thematic analysis was applied to identify the following themes regarding HIV-negative male couples' attitudes toward PrEP use: (1) PrEP and condom use; (2) concerns about PrEP (e.g., effectiveness, side effects, and promoting sexually risky behavior); and (3) accessibility of PrEP. Some thought PrEP could be a part of couples' agreement because it could help reduce sexual anxiety and sexual risk, and would help keep the couple safe. Others described PrEP use with an agreement as something for "others". Some were also concerned that incorporating PrEP could usurp the need for a sexual agreement in a couples' relationship. These themes highlight the need to improve informational messaging and promotion efforts about PrEP among HIV-negative male couples

PrEP Whores and HIV Prevention: The Queer Communication of HIV Pre-Exposure Prophylaxis (PrEP).

Science.gov (United States)

Spieldenner, Andrew

2016-12-01

HIV pre-exposure prophylaxis (PrEP) has been introduced as another biomedical tool in HIV prevention. Whereas other such tools-including post-exposure prophylaxis (PEP) and interruption of perinatal transmission-have been embraced by those impacted by HIV, PrEP has been met with more conflict, especially within the gay community and HIV organizations. The "PrEP whore" has come to designate the social value and personal practices of those taking PrEP. This study examines the "PrEP whore" discourse by using queer theory and quare theory. Within these theoretical vantage points, the study explicates four discursive areas: slut shaming, dirty/clean binaries, mourning the loss of condoms, and reclaiming the inner whore. The study illuminates possible discursive strategies that lie outside of the domains of public health and within the individual and community.

Incorporation of Pr into LuAG ceramics

Science.gov (United States)

Marchewka, M. R.; Chapman, M. G.; Qian, H.; Jacobsohn, L. G.

2017-06-01

An investigation of the effects of Pr in (Lu1-xPrx)3Al5O12 (LuAG:Pr) ceramics was carried out by means of x-ray diffraction (XRD), energy dispersive x-ray spectroscopy (EDX), and attenuated total reflection Fourier transform infrared spectroscopy (ATR FTIR) measurements coupled with luminescence measurements. It was found that the Pr concentration that maximizes luminescence emission depends on the thermal processing conditions. While the calcined LuAG:Pr powder showed maximum luminescence emission for Pr concentrations between 0.18 and 0.33 at.%, maximum emission of ceramic bodies sintered at 1500 °C for 20 h was obtained with Pr concentrations between 0.018 and 0.18 at.%. Further, for short sintering times up to about 3 h, luminescence emission intensity is maximum for Pr concentrations around 0.33 at.%. Longer sintering times lead to the formation of PrAlO3 as a secondary phase, concomitant with a reduction of the intensity of luminescence emission.

Business ethics and virtue: on Robert C. Solomon's many ways of being ethical.

OpenAIRE

Gallego Salvador, Francisco

2013-01-01

The present Thesis explores the possibility of applying a virtue ethics framework, based upon the Aristotelian tradition, into business ethics. The purpose of the Thesis is twofold: to give an overview of virtue ethics through Richard Taylor’s portrait and to offer a specific account of virtue ethics focused on the business realm. The examination of this virtue ethics proposal is largely founded on Robert C. Solomon’s works, which constitute the cornerstone of this Thesis. However, the critic...

PrPC from stem cells to cancer

Directory of Open Access Journals (Sweden)

Séverine eMartin-Lannerée

2014-09-01

Full Text Available The cellular prion protein PrPC was initially discovered as the normal counterpart of the pathological scrapie prion protein PrPSc, the main component of the infectious agent of Transmissible Spongiform Encephalopathies. While clues as to the physiological function of this ubiquitous protein were greatly anticipated from the development of knock-out animals, PrP-null mice turned out to be viable and to develop without major phenotypic abnormalities. Notwithstanding, the discovery that hematopoietic stem cells from PrP-null mice have impaired long-term repopulating potential has set the stage for investigating into the role of PrPC in stem cell biology. A wealth of data have now exemplified that PrPC is expressed in distinct types of stem cells and regulates their self-renewal as well as their differentiation potential. A role for PrPC in the fate restriction of embryonic stem cells has further been proposed. Paralleling these observations, an overexpression of PrPC has been documented in various types of tumours. In line with the contribution of PrPC to stemness and to the proliferation of cancer cells, PrPC was recently found to be enriched in subpopulations of tumour-initiating cells. In the present review, we summarize the current knowledge of the role played by PrPC in stem cell biology and discuss how the subversion of its function may contribute to cancer progression.

PrP-C1 fragment in cattle brains reveals features of the transmissible spongiform encephalopathy associated PrPsc.

Science.gov (United States)

Serra, Fabienne; Müller, Joachim; Gray, John; Lüthi, Ramona; Dudas, Sandor; Czub, Stefanie; Seuberlich, Torsten

2017-03-15

Three different types of bovine spongiform encephalopathy (BSE) are known and supposedly caused by distinct prion strains: the classical (C-) BSE type that was typically found during the BSE epidemic, and two relatively rare atypical BSE types, termed H-BSE and L-BSE. The three BSE types differ in the molecular phenotype of the disease associated prion protein, namely the N-terminally truncated proteinase K (PK) resistant prion protein fragment (PrP res ). In this study, we report and analyze yet another PrP res type (PrP res-2011 ), which was found in severely autolytic brain samples of two cows in the framework of disease surveillance in Switzerland in 2011. Analysis of brain tissues from these animals by PK titration and PK inhibitor assays ruled out the process of autolysis as the cause for the aberrant PrP res profile. Immunochemical characterization of the PrP fragments present in the 2011 cases by epitope mapping indicated that PrP res-2011 corresponds in its primary sequence to the physiologically occurring PrP-C1 fragment. However, high speed centrifugation, sucrose gradient assay and NaPTA precipitation revealed biochemical similarities between PrP res-2011 and the disease-associated prion protein found in BSE affected cattle in terms of detergent insolubility, PK resistance and PrP aggregation. Although it remains to be established whether PrP res-2011 is associated with a transmissible disease, our results point out the need of further research on the role the PrP-C1 aggregation and misfolding in health and disease. Copyright © 2017. Published by Elsevier B.V.

STRATEGIJSKA ULOGA PR U SPORTU

Directory of Open Access Journals (Sweden)

Duško Tomić

2005-05-01

Full Text Available PR in the modern world are developed with rapid speed and become important aspect of strategic management. Modern menagers are very interesting in PR and they observe that there is not successful strategy without experiance theory and practice in PR. The goals must be defined, basic phylosophy to, and managers must take responsability and describe everithing what they have to do. It must be financial fond and evaluation must be done

Progesterone receptors (PR) mediate STAT actions: PR and prolactin receptor signaling crosstalk in breast cancer models.

Science.gov (United States)

Leehy, Katherine A; Truong, Thu H; Mauro, Laura J; Lange, Carol A

2018-02-01

Estrogen is the major mitogenic stimulus of mammary gland development during puberty wherein ER signaling acts to induce abundant PR expression. PR signaling, in contrast, is the primary driver of mammary epithelial cell proliferation in adulthood. The high circulating levels of progesterone during pregnancy signal through PR, inducing expression of the prolactin receptor (PRLR). Cooperation between PR and prolactin (PRL) signaling, via regulation of downstream components in the PRL signaling pathway including JAKs and STATs, facilitates the alveolar morphogenesis observed during pregnancy. Indeed, these pathways are fully integrated via activation of shared signaling pathways (i.e. JAKs, MAPKs) as well as by the convergence of PRs and STATs at target genes relevant to both mammary gland biology and breast cancer progression (i.e. proliferation, stem cell outgrowth, tissue cell type heterogeneity). Thus, rather than a single mediator such as ER, transcription factor cascades (ER>PR>STATs) are responsible for rapid proliferative and developmental programming in the normal mammary gland. It is not surprising that these same mediators typify uncontrolled proliferation in a majority of breast cancers, where ER and PR are most often co-expressed and may cooperate to drive malignant tumor progression. This review will primarily focus on the integration of PR and PRL signaling in breast cancer models and the importance of this cross-talk in cancer progression in the context of mammographic density. Components of these PR/PRL signaling pathways could offer alternative drug targets and logical complements to anti-ER or anti-estrogen-based endocrine therapies. Copyright © 2017 Elsevier Ltd. All rights reserved.

Determination of the differences in oxidation potentials for the Pr3+/Pr2+ and Ce3+/Ce2+ pairs in halide melts

International Nuclear Information System (INIS)

Mikheev, N.B.; Auerman, L.N.; Rumer, I.A.; D'yachkova, R.A.

1983-01-01

Cocrystallization has been used with the (PrOCl)/sub s. ph/ - (PrCl 2 , PrCl 3 , SrCl 2 ) melt system to examine the dependence of the cerium(III) cocrystallization coefficient on the X/sub Pr 2+ /X/sub Pr 3+ / ratio in the melt. Measurement has been made in this way of the difference in oxidation potentials for the pairs Pr 3+ /Pr 2+ and Ce 3+ /Ce 2+ : ΔE/sub Pr 3+ /Pr 2+0 -E/sub Ce 3+ /Ce 2+ / 0 , which is 0.08 +/- 0.04 V for chloride

Electronic structures of PrBa2Cu3O7, Pr2Ba4Cu7O15-y(y=0,1), and PrBa2Cu4O8 based on LSDA+U method

International Nuclear Information System (INIS)

Tavana, A.; Shirazi, M.; Akhavan, M.

2009-01-01

The electronic structures of PrBa 2 Cu 3 O 7 (Pr123), Pr 2 Ba 4 Cu 7 O 15-y (Pr247), and PrBa 2 Cu 4 O 8 (Pr124) cuprates have been obtained using density-functional theory in the local spin density approximation plus onsite Coulomb interaction (LSDA+U). Onsite Hubbard correlation, U, has been considered for Pr-f and Cu-d orbitals and the effects of considering these correlation corrections on the Pr-O hybridizations have been inspected. Results imply that the Pr ionization state in Pr123 system is constituted from two different configurations, and the energy of the f states in these two configurations has an important role in superconductivity properties of the system. Our calculations also show that in both Pr124 and Pr247 systems, suppression of superconductivity is weaker than that in the Pr123 system. This occurs due to the weaker Pr-O bond in both Pr124 and Pr247 systems. The role of the double chain and single chain on the conduction properties of these compounds has been investigated. We have also studied the effect of oxygen deficiency in Pr247 system, which seems to revive superconductivity in this system. Investigating the hole carriers in the CuO 2 plane shows a correlation between superconductivity suppression and hole decrement in the planes. (Abstract Copyright [2009], Wiley Periodicals, Inc.)

On the nature of the dhcp to fcc transition under pressure in Pr and Pr-Th alloys

International Nuclear Information System (INIS)

Vijayakumar, V.; Godwal, B.K.; Sikka, S.K.; Chidambaram, R.

1988-01-01

The results of electrical resistance (R), thermoelectric power (TEP) and X-ray diffraction measurements on praseodymium (Pr) and its alloys with thorium under pressure are reported. The maximum in R vs P curve exhibited by Pr persists only in the dhcp phase of Pr-Th alloy. X-ray measurements confirmed that in the alloys also the maximum in R vs P curve is due to the dhcp → fcc transition. Thus the behaviour of Pr and Pr-Th alloys is different from that of La and its alloys with Ce and Th where the maximum in the R vs P curve is electronic in origin and is exhibited by the dhcp, fcc and dist fcc phases. (author). 14 refs

Molecular insights on analogs of HIV PR inhibitors toward HTLV-1 PR through QM/MM interactions and molecular dynamics studies: comparative structure analysis of wild and mutant HTLV-1 PR.

Science.gov (United States)

Selvaraj, Chandrabose; Singh, Poonam; Singh, Sanjeev Kumar

2014-12-01

Retroviruses HTLV-1 and HIV-1 are the primary causative agents of fatal adult T-cell leukemia and acquired immune deficiency syndrome (AIDS) disease. Both retroviruses are similar in characteristics mechanism, and it encodes for protease that mainly involved in the viral replication process. On the basis of the therapeutic success of HIV-1 PR inhibitors, the protease of HTLV-1 is mainly considered as a potential target for chemotherapy. At the same time, structural similarities in both enzymes that originate HIV PR inhibitors can also be an HTLV-1 PR inhibitor. But the expectations failed because of rejection of HIV PR inhibitors from the HTLV-1 PR binding pocket. In this present study, the reason for the HIV PR inhibitor rejection from the HTLV-1 binding site was identified through sequence analysis and molecular dynamics simulation method. Functional analysis of M37A mutation in HTLV PR clearly shows that the MET37 specificity and screening of potential inhibitors targeting MET37 is performed by using approved 90% similar HIV PR inhibitor compounds. From this approach, we report few compounds with a tendency to accept/donate electron specifically to an important site residue MET37 in HTLV-1 PR binding pocket. Copyright © 2014 John Wiley & Sons, Ltd.

Pr4N2S3 and Pr4N2Se3: two non-isostructural praseodymium(iii) nitride chalcogenides

International Nuclear Information System (INIS)

Lissner, Falk; Schleid, Thomas

2005-01-01

The non-isostructural nitride chalcogenides of praseodymium, Pr 4 N 2 S 3 and Pr 4 N 2 Se 3 , are formed by the reaction of the praseodymium metal with sodium azide (NaN 3 ), praseodymium trihalide (PrX 3 ; X = Cl, Br, I) and the respective chalcogen (sulfur or selenium) at 900 C in evacuated silica ampoules after seven days. Both crystallize monoclinically in space group C2/c (Pr 4 N 2 S 3 : a = 1788.57(9), b = 986.04(5), c = 1266.49(6) pm, β = 134.546(7) , Z = 8; Pr 4 N 2 Se 3 : a = 1311.76(7), b = 1017.03(5), c = 650.42(3) pm, β = 90.114(6) , Z = 4). The crystal structures of both compounds show a layered construction, dominated by N 3- -centred (Pr 3+ ) 4 tetrahedra which share a common edge first. Continuing linkage of the so resulting bitetrahedral [N 2 Pr 6 ] 12+ units via the non-connected vertices to layers according to [stack ∞ 2 ]{[N(Pr) 2/2 e (Pr') 2/2 v ] 3+ } forms different kinds of tetrahedral nets which can be described as layers consisting of ''four- and eight-rings'' for Pr 4 N 2 S 3 and as layers of ''six-rings'' for Pr 4 N 2 Se 3 . Whereas the crystal structure of Pr 4 N 2 S 3 exhibits four different Pr 3+ cations with coordination numbers of six (2 x) and seven (2 x) against N 3- and S 2- , the number of cations in the nitride selenide (Pr 4 N 2 Se 3 ) is reduced to half (Pr1 and Pr2) also having six- and sevenfold anionic coordination spheres. Further motifs for the connection of [NM 4 ] 9+ tetrahedra in crystal structures of nitride chalcogenides and halides of the rare-earth elements with ratios of N: M = 1: 2 are presented and discussed. (Abstract Copyright [2005], Wiley Periodicals, Inc.) [de

A gift of prophecy essays in celebration of the life of Robert Eugene Marshak

CERN Document Server

1994-01-01

Robert Eugene Marshak (1916-92) devoted much of his life to helping other people carry out scientific research and gather to discuss their work. In addition to his scientific statesmanship, he was an extraordinarily gifted research scientist, and many of his scientific contributions have been prophetic. This book pays homage to his creativity and continuing work, with contributions from many of the people whose lives have been influenced by him.

The Aspiring Adept: Robert Boyle and His Alchemical Quest (Lawrence M. Principe)

Science.gov (United States)

Kovac, Jeffrey

1999-10-01

Robert Boyle is widely regarded as the Father of Modern Chemistry, who broke once and for all from the irrational, misguided alchemy that preceded him. One of the goals of this carefully researched and argued new book by Lawrence M. Principe, Assistant Professor in the Department of Chemistry and the Institute for the History of Science, Medicine, and Technology at The Johns Hopkins University, is to refute the two errors in this characterization of Boyle and to understand his life, thought, and work in the intellectual and social context of his time. This book is not for the casual reader; it is a detailed scholarly treatise in the history of science, but it provides a fresh and interesting perspective on Boyle and on the development of chemistry in the 17th century. Boyle is usually characterized as a modern scientist and his most famous book, The Skeptical Chymist, as a critique of traditional alchemy. Principe demonstrates that this characterization is based on a selective and sometimes incorrect reading of Boyle's works. Like Newton, Boyle was deeply involved in traditional transmutational alchemy, reading the works of other alchemists, performing experiments, and even witnessing transmutations. Alchemy, however, was not a monolith and Boyle adhered to what Principe tentatively identifies as a uniquely English school of supernatural alchemy. According to Principe, The Skeptical Chymist was mainly a criticism of the Paracelsians interested in chemical medicine rather than a defense of what we would now regard as modern chemistry. To further support his characterization of Boyle and to better reveal Boyle's involvement in alchemyparticularly the transmutation of base metals to gold, termed chrysopoeiaPrincipe has reconstructed from some 20 fragments one of Boyle's alchemical manuscripts, his Dialogue on the Transmutation of Metals. The full text of this lost work is included as Appendix 1. Two other primary sources, Interview Accounts of Transmutations and

Energy transfer between Pr3+ and Mn2+ in K2YZr(PO4)3: Pr, Mn phosphor

International Nuclear Information System (INIS)

Liang Wei; Wang Yuhua

2011-01-01

Research highlights: → Pr 3+ , Mn 2+ co-doped K 2 YZr(PO 4 ) 3 phosphor is a novel type of practical visible quantum cutting phosphor in promising application. → The optimal quantum efficiency (QE) of this co-doped system K 2 YZr(PO 4 ) 3 : Pr 3+ , Mn 2+ reached to 126.3%. → The Mn 2+6 A 1g → 4 E g - 4 A 1g transition was found to coincide well with the 1 S 0 → 1 I 6 transition of Pr 3+ . → The energy transfer from Pr 3+ to Mn 2+ was also observed, converting the first photon from the PCE of Pr 3+ into the red emission of Mn 2+ , and the QC process occurred in this Pr 3+ , Mn 2+ co-doped K 2 YZr(PO 4 ) 3 phosphor. - Abstract: Pr 3+ , Mn 2+ co-doped K 2 YZr(PO 4 ) 3 samples were prepared by solid-state reaction method and their photoluminescence (PL) properties were investigated in ultra-violet (UV) and vacuum ultra-violet (VUV) region. The results indicated that in Pr 3+ singly doped K 2 YZr(PO 4 ) 3 sample, the first-step transition ( 1 S 0 → 1 I 6 , 3 P J around 405 nm) of Pr 3+ is near the ultraviolet (UV) range, not useful for practical application. When Mn 2+ was doped as a co-activator ion, the energy of 1 S 0 → 1 I 6 , 3 P J transition can be transferred synchronously from Pr 3+ to Mn 2+ and then emit a visible photon. The optimal quantum efficiency (QE) of this co-doped system K 2 YZr(PO 4 ) 3 : Pr 3+ , Mn 2+ reached to 126.3%, suggesting a novel type of practical visible quantum cutting phosphor in promising application.

E-PR technologies in political party activities

OpenAIRE

Tereshchuk Vitaliy Ivanovych

2016-01-01

The article discusses the role of the Internet as an important communicative tool in the field of political PR. The article reviews the characteristics of PR-activities on the Internet and the features of e-PR in the political sphere. Particular attention is paid to the system of political party’s e-PR tools.

Phase diagrams of Pr-C system

International Nuclear Information System (INIS)

Eremenko, V.N.; Velikanova, T.Ya.; Gordijchuk, O.V.

1988-01-01

Results of the X-ray phase, metallographic and high-temperature differential thermal analysis are used for the first time to plot a diagram of the Pr-C system state. Carbides are formed in the system: Pr 2 C 3 with the bcc-structure of the Pu 2 C 3 type and with the period a 0 = 0.85722+-0.00026 within the phase region + 2 C 3 >, a 0 0.86078+-0.00016 nm - within the region 2 C 3 >+α-PrC 2 ; dimorphous PrC 2 : α-PrC 2 with the bct-structure of the CaC 2 type and periods a 0.38517+-0.00011, c 0 = 0.64337+-0.00019 nm; β-PrC 2 with the fcc-structure, probably, of KCN type. Dicarbide melts congruently at 2320 grad. C, forming eutectics with graphite at 2254+-6 grad. C and composition of 71.5% (at.)C. It is polymorphously transformed in the phase region 2 C 3 > + 2 > at 1145+-4 grad. C, and in the region 2 >+C at 1134+-4 grad. C. Sesquicarbide melts incongruently at 1545+-4 grad. C. The eutectic reaction L ↔ + 2 C 3 > occurs at 800+-4 grad. C, the eutectic composition ∼ 15% (at.)C. The temperature of the eutectoid reaction ↔ + 2 C 3 > is 675+-6 grad C. The limiting carbon solubility in β-Pr is about 8 and in α-Pr it is about 5% (at.)

Robert Schumann and translation: poetic creativity, simultaneity and movement

Directory of Open Access Journals (Sweden)

João Azenha Junior

2012-07-01

Full Text Available In diesem Aufsatz werden die Gesammelten Schriften über Musik und Musiker von Robert Schumann untersucht, insbesondere die Rezensionen, die der Komponist zwischen 1834 und 1836 verfasst hat. Es soll festgestellt werden, inwiefern sich darin die wichtigsten Auffassungen über Sprache und Übersetzung, die Ende des 18. und Beginn des 19. Jahrhunderts in Deutschland entstanden, wiederfinden. Im Vordergrund der Untersuchung steht die Dimension der Bewegung, die sich sowohl im Individuum als auch in der Zeit festmachen lässt. Im Individuum manifestiert sich die Bewegung als ein sehr persönlicher Vorgang, da es sich innerhalb verschiedener Zeichensysteme bewegt, die seine Gedanken ausdrücken; oder aber es bewegt sich innerhalb verschiedener Sprachen. Die Zeitdimension wiederum bedeutet, in ein Umfeld einzutauchen, das die Zeitbarrieren überwindet und die Vergangenheit auf einen Schlag mit der Gegenwart und der Zukunft verbindet.

Hooke's figurations: a figural drawing attributed to Robert Hooke.

Science.gov (United States)

Hunter, Matthew C

2010-09-20

The experimental philosopher Robert Hooke (1635-1703) is known to have apprenticed to the leading painter Peter Lely on his first arrival in London in the late 1640s. Yet the relevance of Hooke's artistic training to his mature draughtsmanship and identity has remained unclear. Shedding light on that larger interpretive problem, this article argues for the attribution to Hooke of a figural drawing now in Tate Britain (T10678). This attributed drawing is especially interesting because it depicts human subjects and bears Hooke's name functioning as an artistic signature, both highly unusual features for his draughtsmanship. From evidence of how this drawing was collected and physically placed alongside images by leading artists in the early eighteenth century, I suggest how it can offer new insight into the reception of Hooke and his graphic work in the early Enlightenment.

Professor Barrie Vernon-Roberts, AO, MD, BSc, PhD, FRCPath, FRCPA, FAOrthA (Hon), FRS.SA.

Science.gov (United States)

Rainsford, K D; Haynes, D R

2013-08-01

This issue of Inflammopharmacology contains papers that have been submitted to commemorate the life and work of Professor Barrie Vernon-Roberts, an outstanding clinical scientist in the field of bone pathology and its pharmacological regulation. This review briefly summarizes his major works and achievements as well as a list of his publications.

Internet innovation in PR management

Directory of Open Access Journals (Sweden)

Ćalasan Veljko B.

2014-01-01

Full Text Available PR Management in the last decade has evolved to unimaginable limits . Its rapid 'evolution ' is directly linked to the development and innovation, above all, of internet communications - Cyber 'world'. Although the genesis of PR management was announced in a way, the changes of the modern PR management have led to a change in the general attitude towards this particular activity. It has become an indispensable factor for the success of every business or social enterprise. In the general run for internet contents with better quality, as an indispensable tool of PR management , for better use of cyberspace , a new generation of PR manager is created, who has almost no resemblance to the earlier managers before two decades. For these reasons, we believe that Internet innovation through the implementation of PR management, changed the world economy and society. Adjusting speed to this, virtual , yet very real world , is proportional to the speed of development of an economic system as a whole, or any company at the micro level , and society in general .Internet is not an important innovation itself to be sufficient to meet the form and define the essence of economic relations. Only its proper exploitation with the constant use of tested and more intense innovation is the only way to the overall success . The absence of the above, in our opinion, is a sure path to failure.

Field building: lessons from the Robert Wood Johnson Foundation's anthology series.

Science.gov (United States)

Isaacs, Stephen L; Knickman, James R

2005-01-01

As editors of the Robert Wood Johnson Foundation's (RWJF's) anthology series, we have examined the entire range of the foundation's grant making since 1972. We found that the RWJF has enjoyed considerable success in building fields--from nurse practitioners to tobacco control to end-of-life care. The RWJF has done this by shaping fields as they were emerging, by adopting a wide-ranging "bear hug" approach, and by staying the course. The lessons from the RWJF's field-building efforts are relevant for both large and small foundations: Small funders can develop strategic plans aimed at building fields in their home state or locality.

La préservation, atout essentiel pour contrer la précarité des ...

International Development Research Centre (IDRC) Digital Library (Canada)

La préservation, atout essentiel pour contrer la précarité des moyens de subsistance en ... Union mondiale pour la conservation de la nature et des ressources ... la recherche menée dans les domaines des sciences sociales, des sciences ...

Bruken av nasjonale prøver

DEFF Research Database (Denmark)

Skov, Poul

2010-01-01

Artiklen beskriver resultater fra en omfattende evaluering af brugen af de nationale prøver i norsk grundskole. De nationale prøver er blevet modtaget positivt af mange kommuner og skoleledere og i mindre grad af lærerne. Resultaterne viser også, at prøverne er styrende for undervisningen, at bru...

Brasil, estudos pós-coloniais e contracorrentes análogas: entrevista com Ella Shohat e Robert Stam

NARCIS (Netherlands)

dos Santos, E.R.S.; Schor, P.

2013-01-01

Interview with Ella Shohat and Robert Stam (Portuguese translation). Original version: Brazil is not Traveling Enough”: On Postcolonial Theory and Analogous Counter-Currents (http://www2.let.uu.nl/solis/psc/P/PVOLUMEFOUR/PVOLUMEFOURPAPERS/P4SHOHAT-STAM-INTERVIEW.pdf)

PrP(ST), a soluble, protease resistant and truncated PrP form features in the pathogenesis of a genetic prion disease.

Science.gov (United States)

Friedman-Levi, Yael; Mizrahi, Michal; Frid, Kati; Binyamin, Orli; Gabizon, Ruth

2013-01-01

While the conversion of PrP(C) into PrP(Sc) in the transmissible form of prion disease requires a preexisting PrP(Sc) seed, in genetic prion disease accumulation of disease related PrP could be associated with biochemical and metabolic modifications resulting from the designated PrP mutation. To investigate this possibility, we looked into the time related changes of PrP proteins in the brains of TgMHu2ME199K/wt mice, a line modeling for heterozygous genetic prion disease linked to the E200K PrP mutation. We found that while oligomeric entities of mutant E199KPrP exist at all ages, aggregates of wt PrP in the same brains presented only in advanced disease, indicating a late onset conversion process. We also show that most PK resistant PrP in TgMHu2ME199K mice is soluble and truncated (PrP(ST)), a pathogenic form never before associated with prion disease. We next looked into brain samples from E200K patients and found that both PK resistant PrPs, PrP(ST) as in TgMHu2ME199K mice, and "classical" PrP(Sc) as in infectious prion diseases, coincide in the patient's post mortem brains. We hypothesize that aberrant metabolism of mutant PrPs may result in the formation of previously unknown forms of the prion protein and that these may be central for the fatal outcome of the genetic prion condition.

PrP(ST, a soluble, protease resistant and truncated PrP form features in the pathogenesis of a genetic prion disease.

Directory of Open Access Journals (Sweden)

Yael Friedman-Levi

Full Text Available While the conversion of PrP(C into PrP(Sc in the transmissible form of prion disease requires a preexisting PrP(Sc seed, in genetic prion disease accumulation of disease related PrP could be associated with biochemical and metabolic modifications resulting from the designated PrP mutation. To investigate this possibility, we looked into the time related changes of PrP proteins in the brains of TgMHu2ME199K/wt mice, a line modeling for heterozygous genetic prion disease linked to the E200K PrP mutation. We found that while oligomeric entities of mutant E199KPrP exist at all ages, aggregates of wt PrP in the same brains presented only in advanced disease, indicating a late onset conversion process. We also show that most PK resistant PrP in TgMHu2ME199K mice is soluble and truncated (PrP(ST, a pathogenic form never before associated with prion disease. We next looked into brain samples from E200K patients and found that both PK resistant PrPs, PrP(ST as in TgMHu2ME199K mice, and "classical" PrP(Sc as in infectious prion diseases, coincide in the patient's post mortem brains. We hypothesize that aberrant metabolism of mutant PrPs may result in the formation of previously unknown forms of the prion protein and that these may be central for the fatal outcome of the genetic prion condition.

Lessons learned from the experiences of informal PrEP users in France: results from the ANRS-PrEPage study.

Science.gov (United States)

Rivierez, I; Quatremere, G; Spire, B; Ghosn, J; Rojas Castro, D

2018-05-30

Before January 2016, Pre-Exposure Prophylaxis (PrEP), a new biomedical HIV-prevention tool, was only available in France via ANRS-Ipergay clinical study but informal use was reported outside this setting. PrEPage qualitative study reports profiles and experiences of participants who used PrEP outside of a biomedical trial before this prevention method was authorized. Between March 2015 and February 2016, a cross-section of twenty-four informal PrEP users, mostly MSM, was recruited to complete in-depth semi-structured interviews. While ANRS-Ipergay was still ongoing (2012-2016), participants described their initiation to PrEP, the way they used it and the difficulties they faced to acquire antiretroviral drugs in an environment where PrEP was still not widely known and often criticized . Through the testimonies, different user profiles and motivation toward informal PrEP use emerged: (a) participants who have increasing difficulties using condoms, (b) "opportunists" who tried PrEP without the intention of using it regularly and (c) participants with a risk aversion who sought additional protection against HIV. Participants chose to use PrEP and/or their usual prevention strategies depending on available supplies, type of partners and individual attitudes toward risk. The feeling of living a safer sex life helped participants to outweigh the fear of possible toxicity and drug resistance. Participants' needs and expectations about PrEP implementation in France were also presented.

Análisis Epistemológico del Modelo de Aprendizaje Acumulativo de Robert Gagne

OpenAIRE

Meza, Anibal; Lazarte, Carmen

2013-01-01

The authors review fundamental aspects of Robert Gagné's Leaming Theory, highlighting its philosophical (positivism and pragmatism) and scientific bases (behaviorism and information processing). Using an epistemological framework, these aspects are assessed in terrns of its theoretical and topical validity, as well as its technical efficiency. It is concluded that Gagné's Theory is eclectic and that its scientific contribution is taxonomic. It represents a theoretical model rather than a theo...

Computerbasiert prüfen [Computer-based Assessment

Directory of Open Access Journals (Sweden)

Frey, Peter

2006-08-01

Full Text Available [english] Computer-based testing in medical education offers new perspectives. Advantages are sequential or adaptive testing, integration of movies or sound, rapid feedback to candidates and management of web-based question banks. Computer-based testing can also be implemented in an OSCE examination. In e-learning environments formative self-assessment are often implemented and gives helpful feedbacks to learners. Disadvantages in high-stake exams are the high requirements as well for the quality of testing (e.g. standard setting as additionally for the information technology and especially for security. [german] Computerbasierte Prüfungen im Medizinstudium eröffnen neue Möglichkeiten. Vorteile solcher Prüfungen liegen im sequentiellen oder adaptiven Prüfen, in der Integration von Bewegtbildern oder Ton, der raschen Auswertung und zentraler Verwaltung der Prüfungsfragen via Internet. Ein Einsatzgebiet mit vertretbarem Aufwand sind Prüfungen mit mehreren Stationen wie beispielsweise die OSCE-Prüfung. Computerbasierte formative Selbsttests werden im Bereiche e-learning häufig angeboten. Das hilft den Lernenden ihren Wissensstand besser einzuschätzen oder sich mit den Leistungen anderer zu vergleichen. Grenzen zeigen sich bei den summativen Prüfungen beim Prüfungsort, da zuhause Betrug möglich ist. Höhere ärztliche Kompetenzen wie Untersuchungstechnik oder Kommunikation eigenen sich kaum für rechnergestützte Prüfungen.

On the PR-algebras

International Nuclear Information System (INIS)

Lebedenko, V.M.

1978-01-01

The PR-algebras, i.e. the Lie algebras with commutation relations of [Hsub(i),Hsub(j)]=rsub(ij)Hsub(i)(i< j) type are investigated. On the basis of former results a criterion for the membership of 2-solvable Lie algebras to the PR-algebra class is given. The conditions imposed by the criterion are formulated in the linear algebra language

PrP aggregation can be seeded by pre-formed recombinant PrP amyloid fibrils without the replication of infectious prions.

Science.gov (United States)

Barron, Rona M; King, Declan; Jeffrey, Martin; McGovern, Gillian; Agarwal, Sonya; Gill, Andrew C; Piccardo, Pedro

2016-10-01

Mammalian prions are unusual infectious agents, as they are thought to consist solely of aggregates of misfolded prion protein (PrP). Generation of synthetic prions, composed of recombinant PrP (recPrP) refolded into fibrils, has been utilised to address whether PrP aggregates are, indeed, infectious prions. In several reports, neurological disease similar to transmissible spongiform encephalopathy (TSE) has been described following inoculation and passage of various forms of fibrils in transgenic mice and hamsters. However, in studies described here, we show that inoculation of recPrP fibrils does not cause TSE disease, but, instead, seeds the formation of PrP amyloid plaques in PrP-P101L knock-in transgenic mice (101LL). Importantly, both WT-recPrP fibrils and 101L-recPrP fibrils can seed plaque formation, indicating that the fibrillar conformation, and not the primary sequence of PrP in the inoculum, is important in initiating seeding. No replication of infectious prions or TSE disease was observed following both primary inoculation and subsequent subpassage. These data, therefore, argue against recPrP fibrils being infectious prions and, instead, indicate that these pre-formed seeds are acting to accelerate the formation of PrP amyloid plaques in 101LL Tg mice. In addition, these data reproduce a phenotype which was previously observed in 101LL mice following inoculation with brain extract containing in vivo-generated PrP amyloid fibrils, which has not been shown for other synthetic prion models. These data are reminiscent of the "prion-like" spread of aggregated forms of the beta-amyloid peptide (Aβ), α-synuclein and tau observed following inoculation of transgenic mice with pre-formed seeds of each misfolded protein. Hence, even when the protein is PrP, misfolding and aggregation do not reproduce the full clinicopathological phenotype of disease. The initiation and spread of protein aggregation in transgenic mouse lines following inoculation with pre

Growth and scintillation properties of Pr doped YAP with different Pr concentrations

International Nuclear Information System (INIS)

Yanagida, Takayuki; Kamada, Kei; Fujimoto, Yutaka; Sugiyama, Makoto; Furuya, Yuki; Yamaji, Akihiro; Yokota, Yuui; Yoshikawa, Akira

2010-01-01

Pr 3+ 0.2, 0.75, and 3 mol% doped YAP single crystalline scintillators were grown by using the micro-pulling down (μ-PD) method. Pr 3+ 0.05 mol% doped YAP was also prepared by using the Czochralski method. In transmittance spectra, 4f-5d absorption line appeared at 230 nm. The μ-PD grown crystals showed intense emission at 290 nm while the Czochralski grown one showed an emission peak at 245 nm in radio luminescence spectra under X-ray excitation. Among them, the Czochralski grown one exhibited the highest light yield under 137 Cs 662 keV excitation and the absolute light yield of this sample was estimated to be 20400±2000 ph/MeV. The decay time constants of these scintillators were around 10 ns due to Pr 3+ 5d-4f transition.

Growth and scintillation properties of Pr doped YAP with different Pr concentrations

Energy Technology Data Exchange (ETDEWEB)

Yanagida, Takayuki, E-mail: t_yanagi@tagen.tohoku.ac.j [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan); Kamada, Kei; Fujimoto, Yutaka; Sugiyama, Makoto; Furuya, Yuki [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan); Yamaji, Akihiro [New Industry Creation Hatchery Center (NICHe), Tohoku University, 6-6-10 Aoba, Aramaki, Aoba-ku, Sendai 980-8579 (Japan); Yokota, Yuui [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan); Yoshikawa, Akira [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan); New Industry Creation Hatchery Center (NICHe), Tohoku University, 6-6-10 Aoba, Aramaki, Aoba-ku, Sendai 980-8579 (Japan)

2010-11-21

Pr{sup 3+} 0.2, 0.75, and 3 mol% doped YAP single crystalline scintillators were grown by using the micro-pulling down ({mu}-PD) method. Pr{sup 3+} 0.05 mol% doped YAP was also prepared by using the Czochralski method. In transmittance spectra, 4f-5d absorption line appeared at 230 nm. The {mu}-PD grown crystals showed intense emission at 290 nm while the Czochralski grown one showed an emission peak at 245 nm in radio luminescence spectra under X-ray excitation. Among them, the Czochralski grown one exhibited the highest light yield under {sup 137}Cs 662 keV excitation and the absolute light yield of this sample was estimated to be 20400{+-}2000 ph/MeV. The decay time constants of these scintillators were around 10 ns due to Pr{sup 3+} 5d-4f transition.

Der Schurke ist kein Schurke mehr. Form und Rollenkonzeption in Robert Walsers "Schneewittchen"

OpenAIRE

Ochoa Savic, Tania

2015-01-01

Robert Walser (1878-1956) fue un escritor suizo que permaneció en el olvido durante décadas tanto para los lectores como para la crítica literaria. Siendo aún joven publicó varias obras como "Schneewittchen" (1901) y "Aschenbrödel" (1901) en revistas renombradas como Die Insel, pero sin llegar a alcanzar la fama literaria. Por otro lado, también intentó, durante su estancia en Stuttgart, probar suerte en el mundo del teatro como actor, mientras trabajaba como oficinista para p...

The Poetry of Robert Burns: “A Melancholy not unallied to Mirth.”

Directory of Open Access Journals (Sweden)

Karyn COSTA

2006-06-01

Full Text Available When Allan Cunningham concluded his 1834 Life of Burns with this critical judgement of Robert Burns’s poetry he was in fact summing up the schizophrenic nature of the Scottish character and identity. Scottish duality is still prevalent in the Highland-Lowland divide, the Catholic-Protestant rivalry, the linguistic differences Scots versus Gaelic, the English and Scottish competition for power, the past battling with the present in the search for a national identity free from myth and a sense ...

Negotiating Primitivist Modernisms: Louis Armstrong, Robert Goffin, and the Transatlantic Jazz Debate

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Daniel Stein

2011-10-01

Full Text Available “Dear Pal Goffin,” Louis Armstrong wrote to his Belgian acquaintance, the lawyer, hobby journalist, and jazz historian Robert Goffin, on July 19, 1944. “‘Man—I’ve been trying to get in touch with you […]. Here’s another hundred dollars toward the five hundred. […] So accept this hundred and I’ll send the other before a ‘Black Cat can ‘Lick his ‘Bu‘hind’ ….. haw haw haw…” (80. Sending Goffin a batch of money along with this playfully worded missive, Armstrong was hoping for quick results. He ...

Quotation. Paratext and Romantic Orientalism: Robert Southey's "The Curse of Kehama" (1810

Directory of Open Access Journals (Sweden)

Ourania Chatsiou

2010-12-01

Full Text Available To a considerable extent, Romantic Orientalist literature is founded on scholasticism, authentication, quotation of antiquarian sources, in other words, on paratext. It constitutes in many respects an oxymoronic, though fascinating and dynamic, symbiosis of repetition / replication and creative imagination / invention. By focusing on Robert Southey’s art of quotation in his extraordinarily abundant notes to his orientalist narrative verse this essay seeks to establish paratext as an integral, formative aspect of Romantic Orientalism and Romantic-period poetics, illustrating the hybridity of the Romantic genius and Romantic poetic creation, and challenging common assumptions about a sublime, universal Romantic-period poetry.

Magnetic properties of Pr ions in perovskite-type oxides

International Nuclear Information System (INIS)

Sekizawa, K.; Kitagawa, M.; Takano, Y.

1998-01-01

Magnetic properties of Pr ions with the controlled valence on the A and B sites of perovskite-type oxides (ABO 3 ) were investigated for two systems. PrSc 1-x Mg x O 3 and BaPr 1-x Bi x O 3 . From the magnetic susceptibility χ versus temperature T curves of PrSc 1-x Mg x O 3 , the χ-T curve for molar Pr 3+ ions on the A site and that of Pr 4+ ions were obtained. The 1/χ-T curves for both ions exhibit the crystalline electric field (CEF) effect and the effective magneticmoment μ eff above 100 K is 3.41 μ B for Pr 3- and 2.58 μ B for Pr 4+ , respectively. The χ-T curve of PrSc 0.8 Mg 0.2 O 3 is similar to that of PrBa 2 Cu 3 O y . In the BaPr 1-x Bi x O 3 system, only one intermediate phase BaPr 0.5 Bi 0.5 O 3 exists, in which Pr and Bi take an ordered arrangement on the B site. The magnetic susceptibility χ for Pr 4+ and that of Pr 3+ in the ordered arrangement with Bi 5- on the B site are much smaller than those for the A site, reflecting the strong CEF effect on the B site. Experimental χ-T curves can be well reproducedby the numerical calculation for Pr 3+ or Pr 4+ ions in the molecular field and the CEF with proper respective parameters. (orig.)

Prévalence, facteurs associés et prédisposant au syndrome ...

African Journals Online (AJOL)

Introduction: Le syndrome métabolique est associé aux maladies cardiovasculaires. L'infection au VIH est devenue aujourd'hui une maladie chronique. L'objectif de cette étude est de déterminer la prévalence, les facteurs associés et prédisposant au syndrome métabolique chez les patients infectés par le VIH sous ...

Robert Heath Lock and his textbook of genetics, 1906.

Science.gov (United States)

Edwards, A W F

2013-07-01

Robert Heath Lock (1879-1915), a Cambridge botanist associated with William Bateson and R. C. Punnett, published his book Recent Progress in the Study of Variation, Heredity, and Evolution in 1906. This was a remarkable textbook of genetics for one appearing so early in the Mendelian era. It covered not only Mendelism but evolution, natural selection, biometry, mutation, and cytology. It ran to five editions but was, despite its success, largely forgotten following Lock's early death in 1915. Nevertheless it was the book that inspired H. J. Muller to do genetics and was remembered by A. H. Sturtevant as the source of the earliest suggestion that linkage might be related to the exchange of parts between homologous chromosomes. Here we also put forward evidence that it had a major influence on the statistician and geneticist R. A. Fisher at the time he was a mathematics student at Cambridge.

Aspects of Pr3+ luminescence in solids

International Nuclear Information System (INIS)

Srivastava, A.M.

2016-01-01

A brief perspective on the influence of “host lattice-Pr 3+ ” interactions on the optical properties of the Pr 3+ ion in solids is presented. How the energy position of the Pr 3+ 4f 1 5d 1 configuration relative to the 1 S 0 , 3 P J and host lattice conduction band levels influences the Pr 3+ optical properties is highlighted by considering solids in which the 4f 1 5d 1 configuration (1) is energetically above the 1 S 0 level, (2) is energetically below the 1 S 0 level, (3) is energetically close to the 1 S 0 level, and (4) overlaps with the host lattice conduction band. - Highlights: • Spectroscopic properties of Pr 3+ in solids is examined. • The influence of Pr 3+ 4f 1 5d 1 energy position relative to the 4f 2 levels is discussed. • The effect of interaction between Pr 3+ 4f 1 5d 1 and host conduction level is illustrated. • The paper identifies potential commercial applications.

Study, Stance, and Stamina in the Research on Teachers' Lives: A Rejoinder to Robert V. Bullough, Jr.

Science.gov (United States)

Kelchtermans, Geert

2008-01-01

Robert V. Bullough, Jr.'s article demonstrated in an impressive way how autobiographical accounts, as well as single person narratives, are intertwined with much larger issues in society, international politics, and economical interests, as well as consequences for people in general and educators in particular. The way he proves capable of…

Hegemoniale Männlichkeit auf dem historischen Prüfstand Hegemonic Masculinity on the Historical Test Bed

Directory of Open Access Journals (Sweden)

Angela Berlis

2006-07-01

Full Text Available Das Konzept der „hegemonialen Männlichkeit“ des australischen Soziologen Robert William Connell hat seit Mitte der achtziger Jahre zunächst im englischsprachigen Raum und – mit Erscheinen seines Hauptwerkes Der gemachte Mann. Konstruktion und Krise von Männlichkeiten (1999 in deutscher Übersetzung – ab Ende der neunziger Jahre auch im deutschen Sprachraum erheblichen Einfluss auf die entstehende Männerforschung ausgeübt. Im vorliegenden Buch wird die „konkrete heuristische Verwertbarkeit“ (S. 22 von Connells Konzept für die historische Forschung und die historisch unterschiedlichen Ausprägungen von Männlichkeit untersucht. Der Sammelband ist als interdisziplinärer Beitrag zur Männlichkeitsforschung konzipiert und enthält insgesamt zwölf geschichts-, literatur- und kulturwissenschaftliche Beiträge sowie einen soziologischen Beitrag. Das Ziel, zur begrifflichen Präzisierung innerhalb der Männer- und Geschlechterforschung beizutragen und das Connellsche Konzept auf seine Brauchbarkeit für die historische Forschung auszuloten, wird in vielen Beiträgen des lesenswerten Sammelbandes verwirklicht.Australian sociologist Robert William Connell’s concept of “hegemonic masculinity” has had considerable influence since the mid-eighties on the emerging body of men’s research, first in English-speaking world and then, following the publication of his central text Masculinities in German translation in 1999, also in the German speaking world. The volume at hand probes the “concrete heuristic utility” of Connell’s concept for historical research and examines the historically different developments of masculinities (22. The collected volume is conceived as an interdisciplinary contribution to masculinity research and contains twelve articles combining perspectives from history, literature, and cultural studies as well as one sociological contribution. The goal of this interesting collected volume is to help make the

Exotic behaviours in the Pr-based filled skutterudites

International Nuclear Information System (INIS)

Sato, H; Sugawara, H; Namiki, T; Saha, S R; Osaki, S; Matsuda, T D; Aoki, Y; Inada, Y; Shishido, H; Settai, R; Onuki, Y

2003-01-01

The exotic features of the Pr-based filled skutterudites are reviewed based on the electronic transport properties, specific heat and de Haas-van Alphen experiments, putting the emphasis on PrFe 4 P 12 and PrOs 4 Sb 12 . As references, the experiments on the related La- and Ce-filled skutterudites are also examined and discussed. Compared to their La reference compounds, the Fermi surface is very similar in PrOs 4 Sb 12 , suggesting the well localized character of 4f electrons, while it looks largely different in PrFe 4 P 12 . For the cyclotron effective mass, both PrFe 4 P 12 and PrOs 4 Sb 12 exhibit a strong enhancement, in reasonable agreement with the large specific heat coefficient

Work and vulnerability: the social question on Robert Castel’s thought

Directory of Open Access Journals (Sweden)

Fabrício Maciel

2015-02-01

Full Text Available The article emphasizes the centrality of the concept of work in the thought of the French sociologist Robert Castel. Despite being best known in Brazil for his concepts of social question and social disaffiliation, the concept of work is crucial in the articulation of the author's thought, notably in his latest writing. The article is divided into four parts. First, it provides a general introduction to the work of Castel. Then, it demonstrates how work can be considered the main social question of contemporary global capitalism. Following, it resumes the relationship between work and social vulnerability. The study concludes by pointing out the importance of understanding work as the main contemporary social issue.

Automatic program development a tribute to Robert Paige

CERN Document Server

Danvy, Olivier; Mairson, Harry; Pettorossi, Alberto

2008-01-01

This work, a tribute to renowned researcher Robert Paige, is a collection of revised papers published in his honor in the Higher-Order and Symbolic Computation Journal in 2003 and 2005.Among them there are two key papers: a retrospective view of his research lines, and a proposal for future studies in the area of the automatic program derivation.The book also includes some papers by members of the IFIP Working Group 2.1 of which Bob was an active member.All of the papers are related to the research interests of Dr Paige, who died in 1999, and, in particular, to the transformational development of programs and their algorithmic derivation from formal specifications.His colleagues, who include Olivier Danvy of the University of Aarhus in Denmark, and Alberto Pettorossi of the University of Rome 'Tor Vergata' in Italy, believe the book provides a renewed stimulus for continuing and deepening Dr Paige's research vision.Prof. Olivier Danvy is editor in chief of the Higher Order for Symbolic Computation journal.

Between genres and styles in the films of Robert Bresson

Directory of Open Access Journals (Sweden)

Luíza Beatriz Alvim

2016-02-01

Full Text Available The films of French director Robert Bresson are considered sober and transcendental. However, in A gentle woman (1969 and in Four nights of a dreamer (1972, he included extracts of quite different genres, like a libertine comedy (the extract of film Benjamim by Michel Deville, 1968, a Shakespearean tragedy (a performance of Shakespeare´s Hamlet and a gangster film (When love possesses us, produced by Bresson himself. In a way, those excerpts represent exactly the opposite of Bresson´s cinema. On the other hand, they still have some familiarity with it. We analyze the approach of those genres in the sequences in Bresson´s films, as well of the styles present in them by the use of music and images of paintings.

The South Pacific in the works of Robert Dean Frisbie

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Nataša Potočnik

2001-12-01

In Tahiti he had ambitious writing plans but after four years of living in Tahiti, he left his plantation and sailed to the Cook Islands. He spent the rest of his life in the Cook Islands and married a local girl Ngatokorua. His new happiness gave him the inspiration to write. 29 sketches appeared in the United States in 1929, collected by The Century Company under the title of The Book of Puka-Puka. His second book My Tahiti, a book of memories, was published in 1937. After the death of Ropati 's beloved wife his goals were to bring up his children. But by this time Frisbie was seriously ill. The family left Puka-Puka and settled down on the uninhabited atoll of Suwarrow. Later on they lived on Rarotonga and Samoa where Frisbie was medically treated. Robert Dean Frisbie died of tetanus in Rarotonga on November 18, 1948. Frisbie wrote in a vivid, graceful style. His characters and particularly the atoll of Puka-Puka are memorably depicted. Gifted with a feeling for language and a sense of humor, he was able to capture on paper the charm, beauty, and serenity of life of the small islands in the South Pacific without exaggerating the stereotypical idyllic context and as such Frisbie's contribution to South Pacific literature went far deeper than that of many writers who have passed through the Pacific and wrote about their experiences. Frisbie's first book The Book of Puka-Puka was published in New York in 1929. It is the most endearing and the most original of his works. It was written during his lifetime on the atoll Puka-Puka in the Cook Islands. It is a collection of 29 short stories, episodic and expressively narrative in style. This is an account of life on Puka-Puka that criticizes European and American commercialism and aggressiveness, and presents the themes of the praise of isolation, the castigation of missionaries, and the commendation of Polynesian economic collectivism and sexual freedom. At the same time, the book presents a portrait of Frisbie himself

Competency profile of PR professional in sport

OpenAIRE

Gazdíková, Lenka

2013-01-01

Title: Competency profile of PR professional in sport Objective: The objective is to identify competencies required to a position of PR professional in sport. The aim of a survey is to verify the level of competencies which follows compiling competency profile and comparison with existing profile of PR specialist. Methods: The objective is achieved using survey, interview and analysis of competency models database. Results: The result of this paper is competency profile of PR professional in ...

[Robert Koch, eminent medical bacteriologist, creator of the applied microbiology and its technnology].

Science.gov (United States)

Suárez Fernández, Guillermo

2012-01-01

In our communication we wish consider to bring at a first instance the egregious figure of Robert Koch a hundred of years after his dead. Nobody else had contributed so much in the development of the bacteriology as unic and independent science. Several books and biographical sketchs had been published about Koch in german, english and french, mainly, with differents detais and interpretations, about his life. However, nobody doubred about his innovator spirit and scientist at highest level. This communication revise and discuss diverse chapters about his life as innovator, researcher, groups leader and Magister.

The molecular mechanism underlying Roberts syndrome involves loss of ESCO2 acetyltransferase activity

DEFF Research Database (Denmark)

Gordillo, M.; Vega, H.; Trainer, A.H.

2008-01-01

Roberts syndrome/SC phocomelia (RBS) is an autosomal recessive disorder with growth retardation, craniofacial abnormalities and limb reduction. Cellular alterations in RBS include lack of cohesion at the heterochromatic regions around centromeres and the long arm of the Y chromosome, reduced growth...... and nonsense mutations associated with decreased levels of mRNA and absence of protein. We found decreased proliferation capacity in RBS cell lines associated with cell death, but not with increased cell cycle duration, which could be a factor in the development of phocomelia and cleft palate in RBS...

DIRECTOR/PRODUCER ROBERT ZEMECKIS DURING FILMING OF 'CONTACT' AT LC39 PRESS SITE

Science.gov (United States)

1997-01-01

Robert Zemeckis, director/producer, and other Warner Bros. crew members oversee the filming of scenes for the movie 'Contact' at Kennedy Space Center's Launch Complex 39 Press Site on January 30. The screenplay for 'Contact' is based on the best-selling novel by the late astronomer Carl Sagan. The cast includes Jodie Foster, Matthew McConaughey, John Hurt, James Woods, Tom Skerritt, David Morse, William Fichtner, Rob Lowe and Angela Bassett. Described by Warner Bros. as a science fiction drama, 'Contact' will depict humankind's first encounter with evidence of extraterrestrial life.

The dilemmas of indefiniteness: Utopia, fluidity and subjectivity in Stone, by Adam Roberts

OpenAIRE

André Cabral de Almeida Cardoso; Carla de Figueiredo Portilho

2017-01-01

http://dx.doi.org/10.5007/2175-8026.2017v70n2p107 Ae, the narrator-protagonist of the novel Stone, by Adam Roberts, is the only criminal in a post-human utopian society in which the use of nanotechnology has allowed humanity to reach its plenitude. Isolated from the rest of society, one day Ae is offered freedom and wealth if he agrees to kill the population of a whole planet. After accepting this offer, Ae must try to fulfil his mission at the same time that he questions himself and trie...

Digitale prøver – et litteraturstudie

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Karen Louise Møller

2015-10-01

Full Text Available Digitale prøveformer bliver efterhånden mere og mere udbredte. Denne artikel er baseret på et litteraturstudie foretaget for at få indsigt i primært forskningslitteraturen om digitale prøveformer. I artiklen præsenterer vi de forskellige typer digitale prøver, der omtales og diskuteres i litteraturen, og vi beskriver de potentielle fordele af bl.a. økonomisk, administrativ og pædagogisk karakter, der ifølge litteraturen kan opnås ved at bruge digitale prøver. Vi beskriver endvidere de udfordringer og potentielle ulemper, der kan være forbundet med indførelse af digitale prøver. Det drejer sig bl.a. om udfordringer hvad angår prøvesystem, organisation, teknologi, kompetenceudvikling og uddannelseskultur. Vi beskriver i artiklen en række konkrete eksempler på digitale prøver, og vi præsenterer resultater fra undersøgelser af underviseres og studerendes oplevelser med digitale prøveformer. Against the backdrop of the rapid spread of digitized tests and exams, this article sets out to present some of the results of a literature study carried out with the aim of gaining insight into the research literature on this topic. The article presents different types of tests, focusing on the financial, administrative, and pedagogical advantages described and discussed in the literature as potentially attainable through the use of digitized exams. In addition, the challenges and potential problems connected with the introduction of digitized tests are described. Among these are challenges related to the test system or to competence development as well as organizational, technological, and cultural challenges. Finally, the article provides concrete descriptions of tests and presents results from select studies of teacher and student experiences of digitized tests.

A diagnosis of modern life: Robert Musil’s Der Mann ohne Eigenschaften as a critical-utopian project

NARCIS (Netherlands)

de Cauwer, S.

2012-01-01

Robert Musil wrote Der Mann ohne Eigenschaften as a critical intervention in the intellectual debates of his time. There are three general questions which prevail in the Musil scholarship: 1. What exactly did he want to critique and how is this critique at work in the novel? 2. What were his aims

Magnetic and thermodynamic properties of the Pr-based ferromagnet PrGe2-δ

Science.gov (United States)

Matsumoto, Keisuke T.; Morioka, Naoya; Hiraoka, Koichi

2018-03-01

We investigated the magnetization, M, and specific heat, C, of ThSi2-type PrGe2-δ. A polycrystalline sample of PrGe2-δ was prepared by arc-melting. Magnetization divided by magnetic field, M / B, increased sharply and C showed a clear jump at the Curie temperature, TC, of 14.6 K; these results indicate that PrGe2-δ ordered ferromagnetically. The magnetic entropy at TC reached R ln 3, indicating a quasi-triplet crystalline electric field (CEF) ground state. The maximum value of magnetic entropy change was 11.5 J/K kg with a field change of 7 T, which is comparable to those of other right rare-earth based magnetocaloric materials. This large magnetic entropy change was attributed to the quasi-triplet ground state of the CEF.

Microstructure and martensitic transformation of Ni-Ti-Pr alloys

Energy Technology Data Exchange (ETDEWEB)

Zhao, Chunwang [Inner Mongolia University of Technology, College of Science, Hohhot (China); Shanghai Maritime University, College of Arts and Sciences, Shanghai (China); Zhao, Shilei; Jin, Yongjun; Hou, Qingyu [Inner Mongolia University of Technology, College of Science, Hohhot (China); Guo, Shaoqiang [Beihang University, Key Laboratory of Micro-nano Measurement, Manipulation and Physics (Ministry of Education), Department of Physics, Beijing (China)

2017-09-15

The effect of Pr addition on the microstructure and martensitic transformation behavior of Ni{sub 50}Ti{sub 50-x}Pr{sub x} (x = 0, 0.1, 0.3, 0.5, 0.7, 0.9) alloys were investigated experimentally. Results show that the microstructures of Ni-Ti-Pr alloys consist of the NiTi matrix and the NiPr precipitate with the Ti solute. The martensitic transformation start temperature decreases gradually with the increase in Pr fraction. The stress around NiPr precipitates is responsible for the decrease in martensitic transformation temperature with the increase in Pr fraction in Ni-Ti-Pr alloys. (orig.)

The PR Officer's Survival Kit.

Science.gov (United States)

Woodrum, Robert L.

1996-01-01

A former corporate public relations (PR) professional shares strategies for communicating and cooperating with the chief executive officer, and particularly for coping with differences in perceptions of the public relations officer's role. Basic attributes of a successful PR professional are outlined: good communication skills, an analytical…

Praseodymium valency from crystal structure in Pr-Ba-Cu-O and (Y-Pr)-Ba-Cu-O single crystals

International Nuclear Information System (INIS)

Collin, G.; Albouy, P.A.; Monod, P.; Ribault, M.

1990-01-01

The substitution of Pr to Y leads to materials with a general formula (Y 1-v Pr v ) (Ba 2-x Pr x ) (Cu 3-y vac y ) O 6+x/2-y+z and with a structural transition around v + x' ∼ 0.5. For v + x 0.5 the crystals are tetragonal, La 1.5 Ba 1.5 Cu 3 O 7±z type, with the characteristic tri-twinning of this phase. The Pr valency, in the range 3-3.2 + depending on preparation conditions, is determined from interatomic distances. Orthorhombic crystals of Pr Ba Cu O prepared at high temperatures exhibit a high amount of defects, y ∼ 0.25 on the Cu(1) site and are semiconductors with a T -1/4 activation law attributed to the praseodymium valence fluctuation

Prática de ensino supervisionada em educação pré-escolar

OpenAIRE

Patrício, Linda Cristel

2017-01-01

O presente relatório de estágio desenvolveu-se no âmbito da Prática de Ensino Supervisionada, tendo por finalidade a obtenção do grau de mestre em Educação Pré-Escolar. A prática educativa foi desenvolvida em contexto de Creche e Jardim-de-Infância e a temática que me mereceu particular reflexão foi o desenvolvimento motor, no sentido de saber que oportunidades neste âmbito, são proporcionadas às crianças. Considerando a educação física como um domínio enquadrado nas Orientações Curricular...

Scintillation properties of μPD-grown Y{sub 4}Al{sub 2}O{sub 9}:Pr (YAM:Pr) crystals

Energy Technology Data Exchange (ETDEWEB)

Drozdowski, Winicjusz, E-mail: wind@fizyka.umk.pl [Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University, Grudziadzka 5, 87-100 Torun (Poland); Brylew, Kamil [Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University, Grudziadzka 5, 87-100 Torun (Poland); Malinowski, Michał [Institute of Microelectronics and Optoelectronics, Koszykowa 75, 00-662 Warsaw (Poland); Turczyński, Sebastian [Institute of Electronic Materials Technology, Wolczynska 133, 01-919 Warsaw (Poland)

2015-05-25

Highlights: • YAM:Pr crystals do scintillate and as such deserve further interest. • Fast d–f luminescence of Pr{sup 3+} ions appears in X-ray excited spectra. • Two components (24 and 790 ns) constitute scintillation time profiles. - Abstract: Y{sub 4}Al{sub 2}O{sub 9}:Pr (YAM:Pr) crystals have been grown by the micro-pulling-down method and their scintillation properties have been investigated. YAM:0.1%Pr displays a light yield of about 2000 ph/MeV and its scintillation time profile contains a prompt component with a decay time of 23.5 ns and a contribution of 20%. Radioluminescence spectra show both fast d–f and slow f–f praseodymium emissions. Low temperature glow curves are complex, consisting of discrete peaks and broad bands related to quasi-continuous trap distributions. Overall scintillation performance of YAM:Pr deteriorates with increasing praseodymium concentration.

Der Effekt von Akupunktur in der Prävention von Prüfungsangst

OpenAIRE

Krüger, Peter

2017-01-01

Prüfungsangst ist ein weit verbreitetes gesellschaftliches Phänomen, das bisher in nur wenigen wissenschaftlichen Ansätzen untersucht wurde. Die Zahl der Studenten, die Gehirn - Doping zur Leistungssteigerung und zur Minimierung von Prüfungsangst nutzen, steigt stetig an. In bisherigen Studien wurde Akupunktur an Herz 7 als vielversprechende Behandlungsalternative dargestellt. Basierend auf diesen Ergebnissen, wurde in dieser Arbeit untersucht, ob eine Einzelpunktakupunktur an Herz 7 die ...

PR's involvement in International Cooperation

NARCIS (Netherlands)

Anonymous,

1995-01-01

In The Netherlands, the Research Station for Cattle, Sheep and Horse Husbandry (in Dutch abbreviated as PR) bridges the gap between more basic and disciplinary research done at universities and research institutes on the one hand and the extension service and the farmers on the other hand. The PR

Identification of PrP sequences essential for the interaction between the PrP polymers and Aβ peptide in a yeast-based assay

OpenAIRE

Rubel, Aleksandr A; Ryzhova, Tatyana A; Antonets, Kirill S; Chernoff, Yury O; Galkin, Alexey P

2013-01-01

Alzheimer disease is associated with the accumulation of oligomeric amyloid β peptide (Aβ), accompanied by synaptic dysfunction and neuronal death. Polymeric form of prion protein (PrP), PrPSc, is implicated in transmissible spongiform encephalopathies (TSEs). Recently, it was shown that the monomeric cellular form of PrP (PrPC), located on the neuron surface, binds Aβ oligomers (and possibly other β-rich conformers) via the PrP23–27 and PrP90–110 segments, acting as Aβ receptor. On the other...

LOS DERECHOS FUNDAMENTALES COMO NORMAS JURÍDICAS MATERIALES EN LA TEORÍA DE ROBERT ALEXY

Directory of Open Access Journals (Sweden)

María Dolores Pérez Jaraba

2011-12-01

Full Text Available RESUMEN. La teoría de los derechos fundamentales de Robert Alexy se fundamenta en un concepto material de norma jurídica que es de carácter doble. Por un lado, se define por los rasgos propios de los principios, en consonancia con la idea de argumentación correcta. Pero, por otro lado, sigue teniendo peso la validez jurídica de las normas que contienen derechos fundamentales, consideradas como reglas constitucionales. Tal y como se argumenta en el trabajo, esta ambigüedad de la teoría de la norma de Alexy permite distintos acercamientos, positivistas y no positivistas, que es signo de su riqueza teórica. ABSTRACT. The theory of the civil rights of Robert Alexy is based on a material concept of rule of law. It is two-fold. On the one hand, is defined by the traits of the principles, consistent with the idea of ??correct argument. But on the other hand, weight is still the legal validity of the rules contained civil rights, constitutional rules considered. As argued in the work, this ambiguity of the norm theory allows for different approaches Alexy, positivist and positivist, which is a sign of its theoretical richness

Charles Robert Darwin and Alfred Russel Wallace: their dispute over the units of selection.

Science.gov (United States)

Ruse, Michael

2013-12-01

Charles Darwin and Alfred Russel Wallace independently discovered the mechanism of natural selection for evolutionary change. However, they viewed the working of selection differently. For Darwin, selection was always focused on the benefit for the individual. For Wallace, selection was as much something of benefit for the group as for the individual. This difference is traced to their different background political-economic views, with Darwin in favor of Adam Smith's view of society and Wallace following Robert Owen in being a socialist.

75 FR 51531 - Proposed Collection; Comment Request for Forms 941, 941-PR, 941-SS, 941-X, 941-X(PR), Schedule B...

Science.gov (United States)

2010-08-20

... 941, 941-PR, 941- SS, 941-X, 941-X(PR), Schedule B (Form 941), Schedule R (Form 941) and Schedule B (Form 941-PR) AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... comments concerning Forms 941 (Employer's Quarterly Federal Tax Return), 941-PR (Planilla Para La...

78 FR 47056 - Proposed Collection; Comment Request for Forms 941, 941-PR, 941-SS, 941-X, 941-X(PR), Schedule B...

Science.gov (United States)

2013-08-02

... 941, 941-PR, 941- SS, 941-X, 941-X(PR), Schedule B (Form 941), Schedule R (Form 941)and Schedule B (Form 941-PR) AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... Forms 941 (Employer's Quarterly Federal Tax Return), 941-PR, 941-SS (Employer's Quarterly Federal Tax...

Conditions promoting and restraining agronomic effectiveness of water-insoluble phosphate sources, in particular phosphate rock (PR): III. 32P-aided soil-PR interaction studies aimed at enhancing P bioavailability from PR

International Nuclear Information System (INIS)

Borlan, Z.; Soare, M.; Gavriluta, I.; Alexandrescu, A.; Stefanescu, D.

2002-01-01

Mobilization of PR and bioavailability of PR-P for plants takes place through complex chemical and biochemical processes that occurs during prolonged soil interaction with PR. There is a high probability that certain processes of a biochemical nature are also involved through proteinaceous ion carriers whose concentration and physiological activity in plant roots may be influenced by means of specially formulated foliar fertilizer compositions. 32 P-aided studies have contributed to identify possibilities of enhancing PR-P bioavailability through foliar fertilizer application. (author)

Robert J. Flaherty and Seáinín Tom Ó Dioráin: Lights, Camera, and (Not Too Much Action

Directory of Open Access Journals (Sweden)

Tomás Ó h-Íde (Ihde

2016-03-01

Full Text Available Famed director Robert Flaherty’s first direct sound film, Oidhche Sheanchais, was recently discovered at Harvard University. This article discusses the impact that the discovery will have on our understanding of this short film, especially as concerns film studies and folklore. It notes several misunderstandings reported in the literature over the years that have now been set right with the finding of the film. The article points to resources held in archives in Ireland and the United States that can additionally address questions related to this film. While a noteworthy contribution to the filmography of Robert Flaherty, the short ‘talkie’ must be approached with caution by folklorists due to the coaching of actors and cinematographic editing.

Cytosolic PrP Can Participate in Prion-Mediated Toxicity

Science.gov (United States)

Thackray, Alana M.; Zhang, Chang; Arndt, Tina

2014-01-01

ABSTRACT Prion diseases are characterized by a conformational change in the normal host protein PrPC. While the majority of mature PrPC is tethered to the plasma membrane by a glycosylphosphatidylinositol anchor, topological variants of this protein can arise during its biosynthesis. Here we have generated Drosophila transgenic for cytosolic ovine PrP in order to investigate its toxic potential in flies in the absence or presence of exogenous ovine prions. While cytosolic ovine PrP expressed in Drosophila was predominantly detergent insoluble and showed resistance to low concentrations of proteinase K, it was not overtly detrimental to the flies. However, Drosophila transgenic for cytosolic PrP expression exposed to classical or atypical scrapie prion inocula showed a faster decrease in locomotor activity than similar flies exposed to scrapie-free material. The susceptibility to classical scrapie inocula could be assessed in Drosophila transgenic for panneuronal expression of cytosolic PrP, whereas susceptibility to atypical scrapie required ubiquitous PrP expression. Significantly, the toxic phenotype induced by ovine scrapie in cytosolic PrP transgenic Drosophila was transmissible to recipient PrP transgenic flies. These data show that while cytosolic PrP expression does not adversely affect Drosophila, this topological PrP variant can participate in the generation of transmissible scrapie-induced toxicity. These observations also show that PrP transgenic Drosophila are susceptible to classical and atypical scrapie prion strains and highlight the utility of this invertebrate host as a model of mammalian prion disease. IMPORTANCE During prion diseases, the host protein PrPC converts into an abnormal conformer, PrPSc, a process coupled to the generation of transmissible prions and neurotoxicity. While PrPC is principally a glycosylphosphatidylinositol-anchored membrane protein, the role of topological variants, such as cytosolic PrP, in prion-mediated toxicity and

Home-based pre-exposure prophylaxis (PrEP services for gay and bisexual men: An opportunity to address barriers to PrEP uptake and persistence.

Directory of Open Access Journals (Sweden)

Steven A John

Full Text Available Gay, bisexual, and other men who have sex with men (GBM are disproportionately affected by the HIV epidemic. Despite the promise of pre-exposure prophylaxis (PrEP in reducing HIV transmission risk, barriers for uptake and persistence exist. We sought to identify whether GBM in a nationwide cohort who have not yet initiated PrEP (n = 906 would prefer to get PrEP-related care from a primary care provider (PCP compared to a specialist clinic or provider. We then sought to identify their level of interest and factors associated with preference for using home-based PrEP services (i.e., HB-PrEP, defined to participants as conducting HIV/STI self-testing from home with PrEP prescription mailing after an initial in-person clinic visit. We examined the associations of demographics, sexual HIV transmission risk, concern about frequent medical checkups associated with PrEP, health care access, and PrEP intentions with preferences for healthcare provider type and HB-PrEP. Concern about frequent medical checkups were associated with preferring a PCP for PrEP-related care, but men who perceived a barrier to bringing up the topic of PrEP with a doctor preferred a specialist clinic or provider more than a PCP. HB-PrEP was more appealing for younger men and those engaged in sexual HIV transmission risk, suggesting HB-PrEP could help reach GBM most vulnerable to HIV and in need of PrEP. HB-PrEP expansion has potential to increase PrEP uptake and persistence among GBM, particularly for men with barriers to clinic-based care and higher intentions to initiate PrEP. Clinical guidelines regarding HB-PrEP are needed to expand its use.

Jurnalistikadan gələn PR-çı

OpenAIRE

Mənsimi, Cəfər; Soltan, Arzu (editör)

2017-01-01

Azerbaycan'da ilk online PR derggisi olan PRoloq.az'da PR uzmanı ve "PR labarotoriya"nın başkanı Afet Yaqubova ile röportaj. PR mütəxəssisi və PR laboratoriyanın direktoru Afət Yaqubova ilə müsahibə,

Thermodynamic database for the Co-Pr system

Directory of Open Access Journals (Sweden)

S.H. Zhou

2016-03-01

Full Text Available In this article, we describe data on (1 compositions for both as-cast and heat treated specimens were summarized in Table 1; (2 the determined enthalpy of mixing of liquid phase is listed in Table 2; (3 thermodynamic database of the Co-Pr system in TDB format for the research articled entitle Chemical partitioning for the Co-Pr system: First-principles, experiments and energetic calculations to investigate the hard magnetic phase W. Keywords: Thermodynamic database of Co-Pr, Solution calorimeter measurement, Phase diagram Co-Pr

Prácticas curriculares

OpenAIRE

García-Gordillo, Mar; Checa Godoy, Antonio; Gómez Mompart, Josep Lluis (Coordinador); Herrero Subías, Mónica (Coordinador)

2015-01-01

Esta ponencia pretende analizar, sucintamente, la situacion presente de las prácticas externas en las facultades de Comunicacion españolas. En una coyuntura sumamente peculiar, no solo para las prácticas de los titulos de Comunicacion, sino para todas las practicas universitarias, por los numerosos y a veces contradictorios cambios acaecidos en la legislacion reciente y los vaivenes normativos de las universidades; por la profunda crisis que viene atravesando el sector de la...

Accuracy evaluation of pendulum gravity measurements of Robert von Sterneck

Directory of Open Access Journals (Sweden)

Alena Pešková

2015-06-01

Full Text Available The accuracy of first pendulum gravity measurements in the Czech territory was determined using both original surveying notebooks of Robert Daublebsky von Sterneck and modern technologies. Since more accurate methods are used for gravity measurements nowadays, our work is mostly important from the historical point of view. In previous  works, the accuracy of Sterneck’s gravity measurements was determined using only a small dataset. Here we process all Sterneck’s measurements from the Czech territory (a dataset ten times larger than in the previous works, and we complexly assess the accuracy of these measurements. Locations of the measurements were found with the help of original notebooks. Gravity in the site was interpolated using actual gravity models. Finally, the accuracy of Sterneck’s measurements was evaluated as the difference between the measured and interpolated gravity.

CRAFTING THE MICROWORLD: HOW ROBERT HOOKE CONSTRUCTED KNOWLEDGE ABOUT SMALL THINGS.

Science.gov (United States)

Lawson, Ian

2016-03-20

This paper investigates the way in which Robert Hooke constructed his microscopical observations. His Micrographia is justifiably famous for its detailed engravings, which communicated Hooke's observations of tiny nature to his readers, but less attention has been paid to how he went about making the observations themselves. In this paper I explore the relationship between the materiality of his instrument and the epistemic images he produced. Behind the pictures lies an array of hidden materials, and the craft knowledge it took to manipulate them. By investigating the often counter-theoretical and conflicting practices of his ingenious microscope use, I demonstrate the way in which Hooke crafted the microworld for his readers, giving insight into how early modern microscopy was understood by its practitioners and audience.

Luminescence dependence of Pr3+ activated SiO2 nanophosphor on Pr3+ concentration, temperature, and ZnO incorporation

CSIR Research Space (South Africa)

Mhlongo, GH

2011-08-01

Full Text Available Green-emitting ZnO nanoparticles were successfully embedded in Pr3+-doped SiO2 by a sol–gel method resulting in a red-emitting ZnO·SiO2:Pr3+ nanocomposite phosphor. The particle morphology and luminescent properties of SiO2:Pr3+ phosphor powders...

Electronic structures of PrBa2Cu3O7 and PrBa2Cu4O8 systems based on LSDA+U approach

International Nuclear Information System (INIS)

Shirazi, M.; Tavana, A.; Akhavan, M.

2007-01-01

Full text: The electronic structures of PrBa 2 Cu 3 O 7 (Pr123) and PrBa 2 Cu 4 O 8 (Pr124) have been obtained by means of the density functional theory in the local spin density approximation plus on-site Coulomb interaction. The correlation correction has been applied to the Cu 3d and Pr 4f states. Calculations show that the localized Pr-O bands form near the Fermi surface and do not cross the Fermi level. Comparison of the hole absorbing ability of pfy and the pdy states shows that pfy state has dominant role in grabbing holes from the system and causes Pr124 to be non-superconducting like Pr123. We suggest that hybridization of Pr and O atoms in Pr124 system is weaker than Pr123 compound and this may be the reason for the higher critical doping of Pr by which the superconductivity is completely suppressed. Displacement of the conduction bands at the Fermi level is the criterion of Cu (3dx2-y2) character, and when Cu (3dx2-y2) character is stronger in a band, the band displaces more intensively under applying the correction Ucu. We estimate the hole-concentration from this displacement, and good agreement with experiment is seen. The displacement of the CuO 2 plane bands in the minority and majority spin channels in Pr124 is less than that in Pr123. Displacement of the double chain bands in Pr124 is higher than the single chain bands in Pr123. This feature is related to a stronger Cu (3dx2-y2) character in the double chain. So, the spin and conduction features of the Pr124 double chains are stronger than Pr123 single chain, which is the origin of metallic behavior of Pr124 at low temperatures.(authors)

Electronic structures of PrBa2Cu3O7 and PrBa2Cu4O8 systems based on LSDA+U approach

International Nuclear Information System (INIS)

Shirazi, M.; Tavana, A.; Akhavan, M.

2007-01-01

Full text: The electronic structures of PrBa 2 Cu 3 O 7 (Pr123) and PrBa 2 Cu 4 O 8 (Pr124) have been obtained by means of the density functional theory in the local spin density approximation plus on-site Coulomb interaction. The correlation correction has been applied to the Cu 3d and Pr 4f states. Calculations show that the localized Pr-O bands form near the Fermi surface and do not cross the Fermi level. Comparison of the hole absorbing ability of pfy and the pdy states shows that pfy state has dominant role in grabbing holes from the system and causes Pr124 to be non-superconducting like Pr123. We suggest that hybridization of Pr and O atoms in Pr124 system is weaker than Pr123 compound and this may be the reason for the higher critical doping of Pr by which the superconductivity is completely suppressed. Displacement of the conduction bands at the Fermi level is the criterion of Cu (3dx2-y2) character, and when Cu (3dx2-y2) character is stronger in a band, the band displaces more intensively under applying the correction Ucu. We estimate the hole-concentration from this displacement, and good agreement with experiment is seen. The displacement of the CuO 2 plane bands in the minority and majority spin channels in Pr124 is less than that in Pr123. Displacement of the double chain bands in Pr124 is higher than the single chain bands in Pr123. This feature is related to a stronger Cu (3dx2-y2) character in the double chain. So, the spin and conduction features of the Pr124 double chains are stronger than Pr123 single chain, which is the origin of metallic behavior of Pr124 at low temperatures. (authors)

Purification and Fibrillation of Full-Length Recombinant PrP.

Science.gov (United States)

Makarava, Natallia; Savtchenko, Regina; Baskakov, Ilia V

2017-01-01

Misfolding and aggregation of prion protein are related to several neurodegenerative diseases in humans such as Creutzfeldt-Jakob disease, fatal familial insomnia, and Gerstmann-Straussler-Scheinker disease. A growing number of applications in the prion field including assays for detection of PrP Sc and methods for production of PrP Sc de novo require recombinant prion protein (PrP) of high purity and quality. Here, we report an experimental procedure for expression and purification of full-length mammalian prion protein. This protocol has been proved to yield PrP of extremely high purity that lacks PrP adducts, oxidative modifications, or truncation, which is typically generated as a result of spontaneous oxidation or degradation. We also describe methods for preparation of amyloid fibrils from recombinant PrP in vitro. Recombinant PrP fibrils can be used as a noninfectious synthetic surrogate of PrP Sc for development of prion diagnostics including generation of PrP Sc -specific antibody.

PrPC displays an essential protective role from oxidative stress in an astrocyte cell line derived from PrPC knockout mice

International Nuclear Information System (INIS)

Bertuchi, Fernanda R.; Bourgeon, Dominique M.G.; Landemberger, Michele C.; Martins, Vilma R.; Cerchiaro, Giselle

2012-01-01

Highlights: ► PrP C in solution acts as a radical scavenger. ► PrP C reduces hydrogen peroxide toxicity in astrocytes. ► Increase in ROS disrupted the cell cycle in the PrP C -knockout astrocytes. ► PrP C prevents the cell death independently of an SOD-like activity. -- Abstract: The PrP C protein, which is especially present in the cellular membrane of nervous system cells, has been extensively studied for its controversial antioxidant activity. In this study, we elucidated the free radical scavenger activity of purified murine PrP C in solution and its participation as a cell protector in astrocytes that were subjected to treatment with an oxidant. In vitro and using an EPR spin-trapping technique, we observed that PrP C decreased the oxidation of the DMPO trap in a Fenton reaction system (Cu 2+ /ascorbate/H 2 O 2 ), which was demonstrated by approximately 70% less DMPO/OH · . In cultured PrP C -knockout astrocytes from mice, the absence of PrP C caused an increase in intracellular ROS (reactive oxygen species) generation during the first 3 h of H 2 O 2 treatment. This rapid increase in ROS disrupted the cell cycle in the PrP C -knockout astrocytes, which increased the population of cells in the sub-G1 phase when compared with cultured wild-type astrocytes. We conclude that PrP C in solution acts as a radical scavenger, and in astrocytes, it is essential for protection from oxidative stress caused by an external chemical agent, which is a likely condition in human neurodegenerative CNS disorders and pathological conditions such as ischemia.

Robert Beuka. American Icon: Fitzgerald’s The Great Gatsby in Critical and Cultural Context.

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Theodora Tsimpouki

2012-02-01

Full Text Available What new can another critical study on F. Scott Fitzgerald’s The Great Gatsby contribute to the already existing abundance of books concerning this national classic?  Yet, in this slim and elegant volume, Robert Beuka has managed to encompass not only the formal scholarship on Gatsby but also a complete and thorough survey of the impact of the novel into the world of popular culture. This parallel attempt throws light on the changing modes of interpretation that have affected our understandin...

Electrocardiographic PR-interval duration and cardiovascular risk

DEFF Research Database (Denmark)

Rasmussen, Peter Vibe; Nielsen, Jonas Bille; Skov, Morten Wagner

2017-01-01

Background Because of ambiguous reports in the literature, we aimed to investigate the association between PR interval and the risk of all-cause and cardiovascular death, heart failure, and pacemaker implantation, allowing for a nonlinear relationship. MethodsWe included 293,111 individuals...... into 7 groups based on the population PR interval distribution. Cox models were used, with reference to a PR interval between 152 and 161 ms (40th to heart failure...... adjustment. A long PR interval conferred an increased risk of heart failure ( > 200 ms; HR, 1.31; 95% CI, 1.22-1.42; P 200 ms (HR, 3...

Redox induces diverse effects on recombinant human wild-type PrP and mutated PrP with inserted or deleted octarepeats.

Science.gov (United States)

Shi, Qi; Chen, Cao; Zhang, Bao-Yun; Zhou, Wei; Xiao, Kang; Dong, Xiao-Ping

2018-04-01

Normal prion protein (PrP) contains two cysteines at amino acids 179 and 214, which may form intra‑ and interpeptide disulfide bonds. To determine the possible effects of this disulfide bridge on the biochemical features of PrP, prokaryotic recombinant human wild‑type PrP (PG5), and mutated PrPs with seven extra octarepeats (PG12) or with all five octarepeats removed (PG0), were subjected to redox in vitro. Sedimentation assays revealed a large portion of aggregation in redox‑treated PG5, but not in PG0 and PG12. Circular dichroism analysis detected increased β‑sheet and decreased α‑helix in PG5 subjected to redox, increased random‑coil and decreased β‑sheet in PG0, and increased random‑coil, but limited changes to β‑sheet content, in PG12. Thioflavin T fluorescence tests indicated that fluorescent value was increased in PG5 subjected to redox. In addition, proteinase K (PK) digestions indicated that PK resistance was stronger in PG12 and PG0 compared with in PG5; redox enhanced the PK resistance of all three PrP constructs, particularly PG0 and PG12. These data indicated that formation of a disulfide bond induces marked alterations in the secondary structure and biochemical characteristics of PrP. In addition, the octarepeat region within the PrP peptide markedly influences the effects of redox on the biochemical phenotypes of PrP, thus highlighting the importance of the number of octarepeats in the biological functions of PrP.

PrPc Does Not Mediate Internalization of PrPSc but Is Required at an Early Stage for De Novo Prion Infection of Rov Cells▿

Science.gov (United States)

Paquet, Sophie; Daude, Nathalie; Courageot, Marie-Pierre; Chapuis, Jérôme; Laude, Hubert; Vilette, Didier

2007-01-01

We have studied the interactions of exogenous prions with an epithelial cell line inducibly expressing PrPc protein and permissive to infection by a sheep scrapie agent. We demonstrate that abnormal PrP (PrPSc) and prion infectivity are efficiently internalized in Rov cells, whether or not PrPc is expressed. At odds with earlier studies implicating cellular heparan sulfates in PrPSc internalization, we failed to find any involvement of such molecules in Rov cells, indicating that prions can enter target cells by several routes. We further show that PrPSc taken up in the absence of PrPc was unable to promote efficient prion multiplication once PrPc expression was restored in the cells. This observation argues that interaction of PrPSc with PrPc has to occur early, in a specific subcellular compartment(s), and is consistent with the view that the first prion multiplication events may occur at the cell surface. PMID:17626095

David Roberts en Córdoba. Vistas de paisaje y arquitectura hacia 1833

Directory of Open Access Journals (Sweden)

Gámiz Gordo, Antonio

2015-12-01

Full Text Available David Roberts' views of Córdoba were carried out in 1833 and later redrafted as lithographs, engravings, and oils. These artworks enjoyed great commercial success and international diffusion due to their thematic and undoubted artistic value. The authors analyze their documentary value as a graphic record -prior to the advent of photography- of the urban landscape and architecture of Cordoba, a city now denominated a World Heritage Site. These images are studied here for the first time as a group, since they are either virtually untraceable or dispersed in museums throughout the world. In addition, these views have been contextualized with information concerning the artist and his Spanish journey, including a letter that he wrote from Córdoba. The documentary reliability of every image is also assessed, while the significant transformations of the places represented are indicated.Las vistas realizadas en Córdoba por David Roberts en 1833, reelaboradas como litografías, grabados y óleos, han gozado de gran éxito comercial y difusión internacional por su temática e indudable interés artístico. Esta investigación profundiza en su valor documental como registros gráficos previos a la aparición de la fotografía, del paisaje y la arquitectura de una ciudad hoy considerada Patrimonio de la Humanidad. Las imágenes presentadas se analizan por primera vez como conjunto, pues algunas son de difícil localización o están dispersas en museos de todo el mundo, y se contextualizan con datos sobre el pintor y su viaje por España, considerando una carta que éste escribió desde Córdoba. También se valora la fiabilidad documental de cada vista, a la vez que se detectan significativas transformaciones de los lugares representados.

Kas noore õpetaja lähtetoetus motiveerib maakooli minema? / Robert Ossipov, Kerstin Kirmjõe, Liina Lüüs...[jt.

Index Scriptorium Estoniae

2010-01-01

Küsimusele vastasid TLÜ õpetajakoolituse magistriõppe üliõpilane Robert Ossipov, TÜ üliõpilane Kerstin Kirmjõe, Tartu Mart Reiniku gümnaasiumi sotsiaalpedagoog Liina Lüüs, Tapa gümnaasiumi füüsikaõpetaja Henrik Sova, TÜ üliõpilane Ott Maidre

Robert L. Oprisko’s Honor: A Phenomenology and Holden Caulfield

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Eliza Quincey

2015-07-01

Full Text Available Robert L. Oprisko’s book, “Honor: A Phenomenology” challenges ones of the most obvious social norms in contemporary society. The concept of honor is one that the “generic” as Sergei Prozorov would say, simply cannot comprehend, nor even make efforts to define. Though fluently used in infamous works such as “The Iliad”, honor has yet to be so explicitly dissected until now. Dr. Oprisko’s book takes a promiscuous and brutally honest approach to “Honor” en generale as well as the many facets associated with such. Similar to fine cuisine and wine, there are many literary accompaniments that serve as wonderful pairings to broaden the kaleidoscope perspectives presented in the book. The contested novel by J.D. Salinger, “The Catcher in the Rye”, although by no means consists of any political or metaphysical theory, contains a stark personification of what is actively presented in every chapter of Dr. Oprisko’s book. Holden Caufield serves as a terrific litmus test for the concepts defined in Oprisko’s work. Holden is by no means a likeable character in the literary world, but however he is raw enough to be able to internalize and beholden things like, “honorableness”, “dignity”, and most importantly for Holden, “face”. Though to the naked eye and untrained mind these “things” which Holden can in fact internalize may seem fairly simple; it challenges the reader to humble oneself and accept that which is the raw. There is no space for semantics and lies in Oprisko’s work. In fact it is so shockingly explicit, one may find themselves utterly offended. Holden Caufield offended readers for years after Sallinger brought him to life over the span of 200 or more so pages, so much that the book was condemned in certain places. Robert L. Oprisko’s, “Honor: A Phenomenology”, in my utmost opinion, contains this same potential. By critically engaging in Oprisko’s spar with “honor”, one may find themselves

Crystal structure of PrOHSO4

International Nuclear Information System (INIS)

Fahey, J.A.; Williams, G.J.B.; Haschke, J.M.

1979-01-01

PrOHSO 4 was prepared by hydrothermal reaction of Pr(OH) 3 with Pr 2 (SO 4 ) 3 x H 2 O at 450 to 500 0 C and 1,200 +- 200 atm water pressure. The space group is P2 1 /c; the cell parameters are a = 4.488, b = 12.495, c = 7.091 A, β = 111.08, Z = 4, d/sub x/ = 4.49 g/cm 3 . Atomic coordinates and anisotropic thermal parameters are tabulated. A stereoscopic protection of the cation coordination sphere is shown and discussed. 2 figures, 3 tables

Experimental Models of Inherited PrP Prion Diseases.

Science.gov (United States)

Watts, Joel C; Prusiner, Stanley B

2017-11-01

The inherited prion protein (PrP) prion disorders, which include familial Creutzfeldt-Jakob disease, Gerstmann-Sträussler-Scheinker disease, and fatal familial insomnia, constitute ∼10%-15% of all PrP prion disease cases in humans. Attempts to generate animal models of these disorders using transgenic mice expressing mutant PrP have produced variable results. Although many lines of mice develop spontaneous signs of neurological illness with accompanying prion disease-specific neuropathological changes, others do not. Furthermore, demonstrating the presence of protease-resistant PrP species and prion infectivity-two of the hallmarks of the PrP prion disorders-in the brains of spontaneously sick mice has proven particularly challenging. Here, we review the progress that has been made toward developing accurate mouse models of the inherited PrP prion disorders. Copyright © 2017 Cold Spring Harbor Laboratory Press; all rights reserved.

Biro Konsultan PR dan Kompetensi Praktisi PR di Era Industrialisasi Komunikasi dan Pencitraan

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Dina Sekar Vusparatih

2013-04-01

Full Text Available The world of communication starts to experience rapid development in various aspects of life, almost all over the world. In Indonesia, it is marked by the emergence of a lot of tv and radio stations, and started the trend of imaging strategy efforts that is used to win the regional election, nasional election, and even to win marketing competition through company’s products or services image branding. This phenomenon is the opportunity for PR consultants to be successful team in designing appropriate communication strategies and appropriate steps to build the image. This opportunity is used by many people which is characterized by the proliferation of consultancies. Competition between consultants becomes so tight considering the companies or organizations that intend to hire consultants also want the best. Competitive bidding process was conducted, to win this, it needs solid team of consultants required in skills and morally. PR competencies of each member are needed to grow into a successful PR consultant. 

Teoria e prática das práticas alternativas

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Fernando D. de Avila-Pires

1995-04-01

Full Text Available São abordados, os fundamentos científicos e a ética da utilização das práticas de medicina alternativa em voga no Brasil. Ressalta-se que, em geral, o termo alternativo não é definido e que pode se referir aos princípios básicos ou aos métodos de diagnóstico e tratamento. Sugere-se que a escolha individual de um sistema terapêutico é mais influenciada por fatores culturais, pela tradição familiar e pela moda, do que pela análise racional dos seus fundamentos. Estabelece-se que o que distingue realmente os diferentes sistemas são seus princípios e não suas práticas.

Teoria e prática das práticas alternativas

Directory of Open Access Journals (Sweden)

Avila-Pires Fernando D. de

1995-01-01

Full Text Available São abordados, os fundamentos científicos e a ética da utilização das práticas de medicina alternativa em voga no Brasil. Ressalta-se que, em geral, o termo alternativo não é definido e que pode se referir aos princípios básicos ou aos métodos de diagnóstico e tratamento. Sugere-se que a escolha individual de um sistema terapêutico é mais influenciada por fatores culturais, pela tradição familiar e pela moda, do que pela análise racional dos seus fundamentos. Estabelece-se que o que distingue realmente os diferentes sistemas são seus princípios e não suas práticas.

Na+/K+-ATPase is present in scrapie-associated fibrils, modulates PrP misfolding in vitro and links PrP function and dysfunction.

Directory of Open Access Journals (Sweden)

James F Graham

Full Text Available Transmissible spongiform encephalopathies are characterised by widespread deposition of fibrillar and/or plaque-like forms of the prion protein. These aggregated forms are produced by misfolding of the normal prion protein, PrP(C, to the disease-associated form, PrP(Sc, through mechanisms that remain elusive but which require either direct or indirect interaction between PrP(C and PrP(Sc isoforms. A wealth of evidence implicates other non-PrP molecules as active participants in the misfolding process, to catalyse and direct the conformational conversion of PrP(C or to provide a scaffold ensuring correct alignment of PrP(C and PrP(Sc during conversion. Such molecules may be specific to different scrapie strains to facilitate differential prion protein misfolding. Since molecular cofactors may become integrated into the growing protein fibril during prion conversion, we have investigated the proteins contained in prion disease-specific deposits by shotgun proteomics of scrapie-associated fibrils (SAF from mice infected with 3 different strains of mouse-passaged scrapie. Concomitant use of negative control preparations allowed us to identify and discount proteins that are enriched non-specifically by the SAF isolation protocol. We found several proteins that co-purified specifically with SAF from infected brains but none of these were reproducibly and demonstrably specific for particular scrapie strains. The α-chain of Na(+/K(+-ATPase was common to SAF from all 3 strains and we tested the ability of this protein to modulate in vitro misfolding of recombinant PrP. Na(+/K(+-ATPase enhanced the efficiency of disease-specific conversion of recombinant PrP suggesting that it may act as a molecular cofactor. Consistent with previous results, the same protein inhibited fibrillisation kinetics of recombinant PrP. Since functional interactions between PrP(C and Na(+/K(+-ATPase have previously been reported in astrocytes, our data highlight this molecule as

Topics in mathematical economics and game theory essays in honor of Robert J. Aumann

CERN Document Server

Wooders, Myrna H

1999-01-01

Since the publication of Theory of Games and Economic Behavior by von Neumann and Morgenstern, the concept of games has played an increasing role in economics. It also plays a role of growing importance in other sciences, including biology, political science, and psychology. Many scientists have made seminal advances and continue to be leaders in the field, including Harsanyi, Shapley, Shubik, and Selten. Professor Robert Aumann, in addition to his important contributions to game theory and economics, made a number of significant contributions to mathematics. This volume provides a collection

Political PR is dying. Long live business PR! / Ilyn Oleg

Index Scriptorium Estoniae

Oleg, Ilyn

2005-01-01

Vene suurima suhtekorraldusagentuuri Imageland Public Relations rahvusvaheliste suhete juhi hinnangul on Venemaal peamisteks probleemideks PR professionaalide vähesus, nende kehv haritus oma erialal, samuti vähene teadlikkus suhtekorralduse tähtsusest äris

Versiones transgresoras y polémicas de Blancanieves: de Robert Walser a João César Monteiro

OpenAIRE

García-Manso, Angélica

2017-01-01

Este artículo analiza dos versiones heterodoxas del cuento de hadas Blancanieves: de un lado, la obra de teatro homónima escrita en 1901 por el suizo Robert Walser; y de otro, la película dirigida en el año 2000 por el cineasta portugués João Cé

Le paysage chez Robert Melançon. Entre milieu citadin et scène baroque

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Élise Lepage

2015-11-01

Full Text Available Cet article interroge le paysage urbain dans Le paradis des apparences (2004 de Robert Melançon en mobilisant tour à tour les concepts de « milieu » (Berque et d’« espaces mineur et majeur » (Desportes, qui invitent à une conception ouverte et dynamique du paysage. Soulignant tout d’abord l’intérêt du sujet melançonien pour les paysages « pauvres » de l’univers citadin, la réflexion se concentre ensuite sur l’importance de la médiation picturale et la valorisation toute baroque des apparences, des jeux d’illusions et autres trompe-l’œil dont fait son miel cette poésie par ailleurs pétrie d’une sobriété toute classique. This article questions the cityscape in Le paradis des apparences (2004 by Robert Melançon by discussing the concepts of « milieu » (Berque and « minor and major places » (Desportes that foster an open and dynamic conception of landscape. It first highlights the subject’s interest for “poor” and marginal cityscapes, before concentrating on the importance of the pictorial mediation and the baroque valorization of appearances, illusions, and other deceptive trompe-l’oeil, which are the very matter of this poetry that may not be as classical and understated as it first appears.

Profesi PR Identik dengan Perempuan ?

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Neni Yulianita

2004-09-01

Full Text Available Profesi Public Relations (PR atau di Indonesia lebih dikenal dengan Humas, seringkali diidentikkan dengan profesi yang pantas dijabat oleh kaum perempuan. Adanya sebagian kalangan masyarakat yang menjudge bahwa profesi ini lebih tepat dijabat oleh kaum perempuan, dengan alasan profesi ini menuntut keterampilan, daya tarik, dan keluwesan. Dengan adanya anggapan tersebut,  tentu saja telah memberikan implikasi pada kaum laki-laki  sehingga menimbulkan keraguan pada mereka untuk menekuni bidang kajian PR/Humas di berbagai Perguruan Tinggi yang memiliki bidang ini. Ironisnya, user masih menganggap kaum laki-lakilah yang lebih tepat menjabat profesi PR, dengan anggapan antara lain bahwa laki-laki lebih energik, aktif, rasional, agresif, memiliki stamina atau fisik yang lebih kuat, dan memiliki kemampuan dalam penguasaan hardware atau teknologi komunikasi mutakhir yang lebih baik dibanding wanita yang dianggap lebih emosional, pasif, dan submisif. Anggapan ini tentu saja sangat merugikan perempuan,  walaupun hasil penelitian Robins dinyatakan bahwa,  “Tidak ada beda  laki-laki dan perempuan yang konsisten dalam kemampuan memecahkan masalah, keterampilan analitis, dorongan kompetitif, motivasi, sosiobilitas, atau kemampuan belajar”.  Untuk itu, dalam tulisan ini, penulis menyajikan jawaban apakah benar Profesi PR lebih tepat dijabat oleh Perempuan?

Prion propagation in cells expressing PrP glycosylation mutants.

Science.gov (United States)

Salamat, Muhammad K; Dron, Michel; Chapuis, Jérôme; Langevin, Christelle; Laude, Hubert

2011-04-01

Infection by prions involves conversion of a host-encoded cell surface protein (PrP(C)) to a disease-related isoform (PrP(Sc)). PrP(C) carries two glycosylation sites variably occupied by complex N-glycans, which have been suggested by previous studies to influence the susceptibility to these diseases and to determine characteristics of prion strains. We used the Rov cell system, which is susceptible to sheep prions, to generate a series of PrP(C) glycosylation mutants with mutations at one or both attachment sites. We examined their subcellular trafficking and ability to convert into PrP(Sc) and to sustain stable prion propagation in the absence of wild-type PrP. The susceptibility to infection of mutants monoglycosylated at either site differed dramatically depending on the amino acid substitution. Aglycosylated double mutants showed overaccumulation in the Golgi compartment and failed to be infected. Introduction of an ectopic glycosylation site near the N terminus fully restored cell surface expression of PrP but not convertibility into PrP(Sc), while PrP(C) with three glycosylation sites conferred cell permissiveness to infection similarly to the wild type. In contrast, predominantly aglycosylated molecules with nonmutated N-glycosylation sequons, produced in cells expressing glycosylphosphatidylinositol-anchorless PrP(C), were able to form infectious PrP(Sc). Together our findings suggest that glycosylation is important for efficient trafficking of anchored PrP to the cell surface and sustained prion propagation. However, properly trafficked glycosylation mutants were not necessarily prone to conversion, thus making it difficult in such studies to discern whether the amino acid changes or glycan chain removal most influences the permissiveness to prion infection.

Thermoelectric power of PrMg3

Science.gov (United States)

Isikawa, Yosikazu; Somiya, Kazuya; Koyanagi, Huruto; Mizushima, Toshio; Kuwai, Tomohiko; Tayama, Takashi

2010-01-01

PrMg3 is supposed to be one of the strongly correlated electron systems originated from the hybridization between the Pr 4f and conduction electrons, because the gigantic electronic specific heat coefficient C/T was observed at low temperatures. However, a typical behaviour of - ln T dependence was not observed in the temperature dependence of the electrical resistivity. The thermoelectric power S is a powerful tool to investigate the density of states at the Fermi energy. We measured carefully the thermoelectric power of PrMg3 in the temperature range between 2 and 300 K. S is extremely small, ranged within ±1 μV/K over the whole temperature. The value of S/T at low temperature limit was also significantly smaller than expected from the specific heat results. We therefore conclude that the density of state at the Fermi level is not enhanced in PrMg3.

Thermoelectric power of PrMg3

International Nuclear Information System (INIS)

Isikawa, Yosikazu; Somiya, Kazuya; Koyanagi, Huruto; Mizushima, Toshio; Kuwai, Tomohiko; Tayama, Takashi

2010-01-01

PrMg 3 is supposed to be one of the strongly correlated electron systems originated from the hybridization between the Pr 4f and conduction electrons, because the gigantic electronic specific heat coefficient C/T was observed at low temperatures. However, a typical behaviour of - ln T dependence was not observed in the temperature dependence of the electrical resistivity. The thermoelectric power S is a powerful tool to investigate the density of states at the Fermi energy. We measured carefully the thermoelectric power of PrMg 3 in the temperature range between 2 and 300 K. S is extremely small, ranged within ±1 μV/K over the whole temperature. The value of S/T at low temperature limit was also significantly smaller than expected from the specific heat results. We therefore conclude that the density of state at the Fermi level is not enhanced in PrMg 3 .

Prépositions et rection verbale étude des prépositions avec, contre, en, par, parmi, pour

CERN Document Server

Ashino, Fumitake; Paillard, Denis

2017-01-01

Cet ouvrage étudie une série de prépositions du français (avec, contre, par, parmi, en et pour) dont la caractéristique commune est d'introduire un terme (Y) constituant un mode d'appréhension particulier du terme (X) avec lequel ces prépositions établissent une relation (X prép Y), et dont un grand nombre d'emplois sont liés à la rection verbale.

77 FR 8751 - Table Saw Blade Contact Injuries; Reopening of the Comment Period

Science.gov (United States)

2012-02-15

... notice in the Federal Register. Commissioner Robert S. Adler voted to deny the request. Commissioner Adler issued a statement. The web address for Commissioner Adler's statement is: http://www.cpsc.gov/pr...

Demographic differences in PrEP–related stereotypes: Implications for implementation

Science.gov (United States)

Golub, Sarit. A.; Gamarel, Kristi E.; Surace, Anthony

2015-01-01

Qualitative interviews about pre-exposure prophylaxis (PrEP) stereotypes were conducted with a subsample of 160 MSM who participated in a PrEP messaging study. Negative stereotypes about PrEP users were identified by 80% of participants. Two types of stereotypes were most common: PrEP users are HIV-infected (and lying about it), and PrEP users are promiscuous and resistant to condom use. Participants’ identification of these stereotype categories differed significantly by demographic factors (i.e. race/ethnicity, education). Expanding access to PrEP requires recognizing potential differences in the experience or anticipation of PrEP-related stereotypes that might impact willingness to discuss PrEP with providers, friends, or partners. PMID:26143247

CTD and Water Sample Data from Research Vessel Robert Gordon Sproul in the NE Pacific, 24 October 2013 (NCEI Accession 0157082)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The expedition by research vessel Robert Gordon Sproul from 23 to 25 October 2013 had the objective to recover a broken mooring from the CORC project (Consortium on...

Interaction between 14-3-3β and PrP influences the dimerization of 14-3-3 and fibrillization of PrP106-126.

Science.gov (United States)

Han, Jun; Song, Qin-Qin; Sun, Peng; Zhang, Jin; Wang, Xu; Song, Juan; Li, Gong-Qi; Liu, Ying-Hui; Mei, Guo-Yong; Shi, Qi; Tian, Chan; Chen, Cao; Gao, Chen; Zhao, Bo; Dong, Xiao-Ping

2014-02-01

Proteins of the 14-3-3 family are universal participate in multiple cellular processes. However, their exact role in the pathogenesis of prion diseases remains unclear. In this study, we proposed that human PrP was able to form molecular complex with 14-3-3β. The domains responsible for the interactions between PrP and 14-3-3β were mapped at the segments of amino acid (aa) residues 106-126 within PrP and aa 1-38 within 14-3-3β. Homology modeling revealed that the key aa residues for molecular interaction were D22 and D23 in 14-3-3β as well as K110 in PrP. Mutations in these aa residues inhibited the interaction between the two proteins in vitro. Our results also showed that recombinant PrP encouraged 14-3-3β dimer formation, whereas PrP106-126 peptide inhibited it. Recombinant 14-3-3β disaggregated the mature PrP106-126 fibrils in vitro. Moreover, the PrP-14-3-3 protein complexes were observed in the brain tissues of normal and scrapie agent 263K infected hamsters. Colocalization of PrP and 14-3-3 was seen in the cytoplasm of human neuroblastoma cell line SH-SY5Y, as well as human cervical cancer cell line HeLa transiently expressing full-length human PrP. Our current data suggest the neuroprotection of PrPC and neuron damage caused by PrPSc may be associated with their functions of 14-3-3 dimerization regulation. Copyright © 2013 Elsevier Ltd. All rights reserved.

Lessons in power: Lyndon Johnson revealed. A conversation with historian Robert A. Caro.

Science.gov (United States)

Caro, Robert A

2006-04-01

No one can lead who does not first acquire power, and no leader can be great who does not know how to use that power. The trouble is that the combination of the two skills is rare. Amassing power requires ambition, a focused pragmatism, and a certain ruthlessness that is often at odds with the daring, idealistic vision needed to achieve great things with that power. The tension is as real in business as it is in politics. This magazine is replete with examples of successful senior managers who could not make the switch from ambitious executive to corporate leader because they did not know what to do with the power they had so expertly accumulated. Robert Caro is a student of power. For the past 27 years, the two-time Pulitzer prize-winning biographer of Robert Moses and Lyndon Johnson has focused on the question of how Johnson amassed and wielded power. Caro's deep understanding of the inner workings of power offers senior executives a nuanced picture of leadership at the highest level. In this wide-ranging conversation, Caro shares his insights about the nature of power, the complexity of ambition, and the role that the greater good can play in the making of a leader. Power doesn't always corrupt, he insists. But what it invariably does is reveal a leader's true nature. "Today, when CEOs have acquired more and more power to change our lives," Caro says,"they have become like presidents in their own right, and they, too, need to align themselves with something greater than themselves if they hope to become truly great leaders."

Radio- and VUV - Excited Luminescence of YAP:Ce, YAP:Pr and YAG:Pr

Science.gov (United States)

2001-01-01

Pr 3+ ions.", Acta Physica Polonica A, 90 pp.407-10, 1996. 6. C. Pedrini, D. Bouttet, C. Dujardin, B. Moine, I. Dafinei, P. Lecoq, M. Koselja, K...34Spectroscopy and thermoluminescence of LuAIO 3:Ce" Acta Physica Polonica A,.90, pp.377-383, 1996 17. A.J. Wojtowicz, J. Glodo, W. Drozdowski, K.R. Przegietka...Malinowski, M.F. Joubert, B. Jacquier. "Simultaneous laser action at blue and orange wavelengths in YAG:Pr 3+ Physica Status Solidi A, 140, pp.K49-52, 1993 5

Mechanically alloyed PrFeB nanocrystalline magnets

International Nuclear Information System (INIS)

Kaszuwara, W.; Leonowicz, M.

1998-01-01

Mechanically alloyed PrFeB nanocrystalline magnets were prepared by extensive ball milling of Pr, Fe and Fe 80 B 20 powders, followed by diffusion annealing. After milling, the material consisted of nanocrystalline α-Fe crystallites embedded in amorphous Pr-rich matrix. Thermomagnetic and calorimetric investigations of the transformations which occurred during annealing showed that the amorphous phase crystallised at 240 C, leading to the formation of crystalline Pr having lattice constants 10% greater than those shown in the ASTM data. This fact indicated that mechanical alloying and low temperature annealing led to the formation of a solid solution of either Fe or B in Pr, which does not exist in the equilibrium state. The Pr 2 Fe 14 B phase was subsequently formed within a temperature range of 420-620 C. The magnetic properties of magnets depend on the phase structure and grain size. Milling time appears to be a decisive processing parameter for the tailoring of the magnetic properties. Depending on the phase structure, the coercivities varied from 100 to 1200 kA/m and, respectively, the remanences from 0.98 T to 0.6 T. The highest maximum energy product was 80 kJ/m 3 . (orig.)

Effects of FlAsH/Tetracysteine (TC) tag on PrP proteolysis and PrPres formation by TC-scanning

Science.gov (United States)

Taguchi, Yuzuru; Hohsfield, Lindsay A.; Hollister, Jason R.

2014-01-01

The FlAsH/tetracysteine (FlAsH/TC) tag is a powerful tool for fluorescent labeling of proteins. However, even small tags such as FlAsH/TC could alter the behavior of the tagged proteins, especially if the insertion occurs at internal sites. Defining the influence of FlAsH/TC on nearby protein-protein interactions might aid in selecting appropriate positions for internal TC insertions and allow the exploitation of serial FlAsH/TC insertions (TC-scanning) as a probe to characterize sites of protein-protein interaction. To explore this application in the context of substrate-protease interactions, we analyzed the effect of FlAsH/TC insertions on proteolysis of cellular prion protein (PrPsen) in in vitro reactions and generation of the C1 metabolic fragment of PrPsen in live neuroblastoma cells. The influence of FlAsH/TC insertion was evaluated by TC-scanning across the cleavage sites of each protease. The results showed that FlAsH/TC inhibited protease cleavage only within limited ranges of the cleavage sites that varied from about 1 to 6 residues-wide depending on the protease, providing an estimate of the PrP residues interacting with each protease. TC-scanning was also used to probe a different type of protein-protein interaction, the conformational conversion of FlAsH-PrPsen to the prion disease-associated isoform, PrPres. PrP constructs with FlAsH/TC insertions at residues 90–96 but not 97–101 were converted to FlAsH-PrPres, identifying a boundary separating loosely versus compactly folded regions of PrPres. Our observations demonstrate that TC-scanning with the FlAsH/TC tag can be a versatile method for probing protein-protein interactions and folding processes. PMID:23943295

Study of PrP - I heterogeneous equilibrium

International Nuclear Information System (INIS)

Vasil'eva, I.G.; Mironov, K.E.; Tarasenko, A.D.

1976-01-01

Using static methods the authors have measured the equilibrium vapor pressure in the system PrP+I 2 at different temperatures and different initial iodine concentrations. The equilibrium reactions in the system have been determined. The reaction of PrP with iodine is irreversible. The content of PrI 3 and I 2 in the gas phase is negligible. The pressure in the system is determined by the partial pressure of phosphorus

Préface

Science.gov (United States)

Chardonnet, Christian; Millot, Guy

2006-10-01

COLOQ, réunion nationale biennale initiée en 1988 par la communauté française des lasers, de l'optique non linéaire et de l'optique quantique atteint sa neuvième édition. Depuis sa création, les objectifs poursuivis sont les suivants : - réunir la communauté française des lasers, de l'optique non linéaire et de l'optique quantique, en dépassant les clivages fondamental/appliqué, recherche publique/industrielle, - faire le point sur les avancées récentes, - permettre aux jeunes chercheurs de se rencontrer, de s'exprimer et de s'aguerrir au plan national. Le but est que tout thésard du domaine de l'optique puisse participer à COLOQ une fois durant sa thèse, présenter son travail et de se confronter à la communauté de l'optique. COLOQ9 s'est tenu, pour sa 9e édition, sur le campus universitaire de Dijon, du 7 au 9 septembre 2005. Il a été une grande réussite : nombre de participants (255) et de présentations scientifiques record (148 affiches), forte représentation des industriels (15) et participation d'environ 200 lycéens aux conférences grand public. Le nombre plus élevé que prévu d'affiches a rendu un peu serrée leur présentation : une attention particulière sera portée à cet aspect lors des prochaines éditions. Ces journées ont été consacrées à des conférences invitées données par des scientifiques de haut niveau et à des présentations sous forme d'affiches. Une plage de temps importante a été réservée pour des discussions autour des affiches. À proximité immédiate de la salle de conférence, l'exposition de matériels spécialisés pour les lasers, l'optique et l'optoélectronique a été une occasion pour les jeunes participants de découvrir et contacter les industriels et les autres grands acteurs de l'optique. L'année 2005 ayant été l'année mondiale de la physique, COLOQ9 a retenu comme thème central ”1905-2005 : à propos d'Einstein". Plusieurs grandes conférences ont été dédiées à ce th

Singlet ground-state fluctuations in praseodymium observed by muon spin relaxation in PrP and PrP0.9

International Nuclear Information System (INIS)

Noakes, D R; Waeppling, R; Kalvius, G M; Jr, M F White; Stronach, C E

2005-01-01

Muon spin relaxation (μSR) in the singlet ground-state compounds PrP and PrP 0.9 reveals the unusual situation of a Lorentzian local field distribution with fast-fluctuation-limit strong-collision dynamics, a case that does not show motional narrowing. Contrary to publications by others, where PrP 0.9 was asserted to have vacancy-induced spin-glass freezing, no spin-glass freezing is seen in PrP 0.9 or PrP down to ≤100mK. This was confirmed by magnetization measurements on these same samples. In both compounds, the muon spin relaxation rate does increase as temperature decreases, demonstrating increasing strength of the paramagnetic response. A Monte Carlo model of fluctuations of Pr ions out of their crystalline-electric-field singlet ground states into their magnetic excited states (and back down again) produces the strong-collision-dynamic Lorentzian relaxation functions observed at each individual temperature but not the observed temperature dependence. This model contains no exchange interaction, and so predicts decreasing paramagnetic response as the temperature decreases, contrary to the temperature dependence observed. Comparison of the simulations to the data suggests that the exchange interaction is causing the system to approach magnetic freezing (by mode softening), but fails to complete the process

Cathodoluminescence properties of SiO2:Pr3+and ZnO.SiO2:Pr3+ phosphor nanopowders

CSIR Research Space (South Africa)

Mhlongo, GH

2010-10-01

Full Text Available regardless of the incorporation of Pr3+ and nanocrystalline ZnO or annealing at 600 °C. The particles were mostly spherical and agglomerated as confirmed by Field Emission Scanning Electron Microscopy. Thermogravimetric analysis of dried gels performed... Science, vol. 45(19): 5228-5236 Cathodoluminescence properties of SiO2:Pr 3+and ZnO·SiO2:Pr 3+ phosphor nanopowders G. H. Mhlongo, O. M. Ntwaeaborwa, M. S. Dhlamini, H. C. Swart, K. T. Hillie ABSTRACT: The successful incorporation of Zn...

Aasta 2000 - meteoor, mis ohustab maailma : Nobeli majanduspreemia värske laureaat soovitab 1. detsembrist külmutada valuutakursid / Robert Mundell ; interv. Marshall Loeb

Index Scriptorium Estoniae

Mundell, Robert

1999-01-01

Nobeli majanduspreemia laureaadi Robert Mundelli intervjuu ajakirja Fortune endisele toimetajale Marshall Loebile teleprogrammis Marketwatch. Aasta 2000 probleem rahaturgudel. Jack Kempi kiri USA presidendile Bill Clintonile

Robert Wood Johnson Foundation Nurse Faculty Scholars program leadership training.

Science.gov (United States)

Campbell, Jacquelyn C; McBride, Angela Barron; Etcher, LuAnn; Deming, Katie

The Robert Wood Johnson Foundation Nurse Faculty Scholars program was created to address the nursing shortage via development of the next generation of national leaders in academic nursing. The leadership training combined development at the scholar's home institution with in-person didactic and interactive sessions with notable leaders in nursing and other disciplines. A curriculum matrix, organized by six domains, was evaluated quantitatively and qualitatively. What set this program apart is that it immersed junior faculty in concerted leadership development with regard to all aspects of the faculty role so that teaching interactively, making use of the latest in information technology, giving testimony before a policy-making group, participating in strategic planning, and figuring out how to reduce the budget without jeopardizing quality were all envisioned as part of the faculty role. The domains covered by this program could easily be used as the framework to plan other leadership-development programs for the next generation of academic leaders. Copyright © 2017 Elsevier Inc. All rights reserved.

Anthony (Tony) ROBERTS 5 March 1948 – 16 January 2008

CERN Multimedia

2008-01-01

Tony came from Netherton, a small town near Birmingham in the English West Midlands, where he grew up with his parents, who ran the local grocery store, "T.W. Roberts & Son". This is where he regularly liked to return, firstly to help his parents and later simply to spend time with them. Here undoubtedly lie the roots of his organizational skills and his ability to get on so well with others. He soon became interested in the rapidly-developing field of computing and this was how he first came to CERN, during the summer of 1973, at the age of 25. He joined the DD Division as an operator responsible for the "calculators" of that time, where he stayed until 1979 when he joined the Fellows and Associates Section of Personnel Division. He participated in the general computerisation of the Administration and continued his career in the Records Office of HR Department, a post he held until the end. Though still very British – ob...

The diffident naturalist Robert Boyle and the philosophy of experiment

CERN Document Server

Sargent, Rose-Mary

2009-01-01

In a provocative reassessment of one of the quintessential figures of early modern science, Rose-Mary Sargent explores Robert Boyle's philosophy of experiment, a central aspect of his life and work that became a model for mid- to late seventeenth-century natural philosophers and for many who followed them. Sargent examines the philosophical, legal, experimental, and religious traditions-among them English common law, alchemy, medicine, and Christianity-that played a part in shaping Boyle's experimental thought and practice. The roots of his philosophy in his early life and education, in his religious ideals, and in the work of his predecessors-particularly Bacon, Descartes, and Galileo-are fully explored, as are the possible influences of his social and intellectual circle. Drawing on the full range of Boyle's published works, as well as on his unpublished notebooks and manuscripts, Sargent shows how these diverse influences were transformed and incorporated into Boyle's views on and practice of experiment.

Novel receptor-like kinases in cacao contain PR-1 extracellular domains.

Science.gov (United States)

Teixeira, Paulo José Pereira Lima; Costa, Gustavo Gilson Lacerda; Fiorin, Gabriel Lorencini; Pereira, Gonçalo Amarante Guimarães; Mondego, Jorge Maurício Costa

2013-08-01

Members of the pathogenesis-related protein 1 (PR-1) family are well-known markers of plant defence responses, forming part of the arsenal of the secreted proteins produced on pathogen recognition. Here, we report the identification of two cacao (Theobroma cacao L.) PR-1s that are fused to transmembrane regions and serine/threonine kinase domains, in a manner characteristic of receptor-like kinases (RLKs). These proteins (TcPR-1f and TcPR-1g) were named PR-1 receptor kinases (PR-1RKs). Phylogenetic analysis of RLKs and PR-1 proteins from cacao indicated that PR-1RKs originated from a fusion between sequences encoding PR-1 and the kinase domain of a LecRLK (Lectin Receptor-Like Kinase). Retrotransposition marks surround TcPR-1f, suggesting that retrotransposition was involved in the origin of PR-1RKs. Genes with a similar domain architecture to cacao PR-1RKs were found in rice (Oryza sativa), barrel medic (Medicago truncatula) and a nonphototrophic bacterium (Herpetosiphon aurantiacus). However, their kinase domains differed from those found in LecRLKs, indicating the occurrence of convergent evolution. TcPR-1g expression was up-regulated in the biotrophic stage of witches' broom disease, suggesting a role for PR-1RKs during cacao defence responses. We hypothesize that PR-1RKs transduce a defence signal by interacting with a PR-1 ligand. © 2013 BSPP AND JOHN WILEY & SONS LTD.

77 FR 68102 - Foreign-Trade Zone 163-Ponce, PR; Application for Subzone; Zimmer Manufacturing BV; Ponce, PR

Science.gov (United States)

2012-11-15

... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [B-81-2012] Foreign-Trade Zone 163--Ponce, PR; Application for Subzone; Zimmer Manufacturing BV; Ponce, PR An application has been submitted to the Foreign-Trade Zones Board (the Board) by CODEZOL, C.D., grantee of FTZ 163, requesting special- purpose subzone...

Obituary: Robert Mowbray Walker, 1929-2004

Science.gov (United States)

Schoenherr, Neil T.

2004-12-01

Robert M. Walker, PhD, Professor of Physics in Arts & Sciences and a faculty fellow of the McDonnell Center for the Space Sciences, died of stomach cancer Thursday, 12 February 2004, in Brussels, Belgium. He was 75. Walker worked on the frontiers of space research for more than four decades. Robert Walker was born in Philadelphia on 6 February 1929. His mother was Dorothy Potter and he considered Roger Potter his father though he was not his biological father. His early years were spent in New York City and in upstate New York. He attended the Bronx High School of Science, earned his BS in physics from Union College and in 1954, he received his PhD in particle physics from Yale University. He subsequently joined the General Electric Laboratory in Schenectady, New York where he studied the radiation effects in solids. His work on defects in irradiated copper is still regarded as the definitive work on the topic. In the early 1960s, Walker's discovery of fossil nuclear particle tracks in minerals was instrumental to new developments in geo-chronology and cosmic ray physics. In particular, his discovery of tracks from nuclei heavier than iron opened a new frontier of cosmic ray physics. He subsequently pioneered the use of plastics to detect and count such nuclei in cosmic ray balloon flights. Beginning in 1966, when he moved to Washington University and became the first McDonnell Professor of Physics, his research interests turned more toward space physics. He was the inaugural director of the McDonnell Center, which was established in 1975 by a gift from aerospace pioneer James S. McDonnell. Walker was a member of the NASA committee that allocated samples of the first returned lunar materials, and his laboratory led the way in deciphering their record of lunar, solar system and galactic evolution. Together with Ghislaine Crozaz and other colleagues, Walker made path breaking laboratory studies of the first moon rocks revealing the history of solar radiation and

Statistical ultrasonics: the influence of Robert F. Wagner

Science.gov (United States)

Insana, Michael F.

2009-02-01

An important ongoing question for higher education is how to successfully mentor the next generation of scientists and engineers. It has been my privilege to have been mentored by one of the best, Dr Robert F. Wagner and his colleagues at the CDRH/FDA during the mid 1980s. Bob introduced many of us in medical ultrasonics to statistical imaging techniques. These ideas continue to broadly influence studies on adaptive aperture management (beamforming, speckle suppression, compounding), tissue characterization (texture features, Rayleigh/Rician statistics, scatterer size and number density estimators), and fundamental questions about how limitations of the human eye-brain system for extracting information from textured images can motivate image processing. He adapted the classical techniques of signal detection theory to coherent imaging systems that, for the first time in ultrasonics, related common engineering metrics for image quality to task-based clinical performance. This talk summarizes my wonderfully-exciting three years with Bob as I watched him explore topics in statistical image analysis that formed a rational basis for many of the signal processing techniques used in commercial systems today. It is a story of an exciting time in medical ultrasonics, and of how a sparkling personality guided and motivated the development of junior scientists who flocked around him in admiration and amazement.

Family planning providers' role in offering PrEP to women.

Science.gov (United States)

Seidman, Dominika; Weber, Shannon; Carlson, Kimberly; Witt, Jacki

2018-03-09

Pre-exposure prophylaxis (PrEP) provides a radically different HIV prevention option for women. Not only is PrEP the first discrete, woman-controlled method that is taken in advance of exposure, but it is both safe and highly effective, offering over 90% protection if taken daily. While multiple modalities of PrEP are in development ranging from vaginal rings to injectables and implants, only PrEP with oral tenofovir/emtricitabine is currently FDA-approved. Family planning clinics provide key access points for many women to learn about and obtain PrEP. By incorporating PrEP services into family planning care, family planning providers have the opportunity to meet women's expectations, ensure women are aware of and offered comprehensive HIV prevention options, and reverse emerging disparities in PrEP access. Despite real and perceived barriers to integrating PrEP into family planning care, providing PrEP services, ranging from education to onsite provision, is not only possible but an important component of providing high-quality sexual and reproductive healthcare to women. Lessons learned from early adopters will help guide those in family planning settings initiating or enhancing PrEP services. Copyright © 2018. Published by Elsevier Inc.

Assistência pré-natal no Brasil

Directory of Open Access Journals (Sweden)

Elaine Fernandes Viellas

2014-08-01

Full Text Available O estudo tem por objetivo analisar a assistência pré-natal oferecida às gestantes usuárias de serviços de saúde públicos e/ou privados utilizando dados da pesquisa Nascer no Brasil, realizada em 2011 e 2012. As informações foram obtidas por meio de entrevista com a puérpera durante a internação hospitalar e dados do cartão de pré- natal. Os resultados mostram cobertura elevada da assistência pré-natal (98,7% tendo 75,8% das mulheres iniciado o pré-natal antes da 16a semana gestacional e 73,1% compareceram a seis ou mais consultas. O pré-natal foi realizado, sobretudo, em unidades básicas (89,6%, públicas (74,6%, pelo mesmo profissional (88,4%, em sua maioria médicos (75,6%, e 96% receberam o cartão de pré-natal. Um quarto das gestantes foi considerado de risco. Do total das entrevistadas, apenas 58,7% foram orientadas sobre a maternidade de referência, e 16,2% procuraram mais de um serviço para a admissão para o parto. Desafios persistem para a melhoria da qualidade dessa assistência, com a realização de procedimentos efetivos para a redução de desfechos desfavoráveis.

Study on GIF PR/PP evaluation methodology

Energy Technology Data Exchange (ETDEWEB)

Lee, B. H.; Kwon, E. H.; Kim, H. D. [KAERI, Daejeon (Korea, Republic of)

2012-10-15

Proliferation resistance (PR) and physical protection (PP) is one of the four technology goals of generation IV nuclear energy systems (NESs). The PR component of the goal focuses on providing strong assurance that generation IV NESs are the least desirable sources for the diversion or undeclared production of nuclear materials, whereas the PP portion of the goal ensures that generation IV NESs are robust against theft and sabotage. In 2002, the road map of the Generation IV International Forum (GIF) envisioned that the R and D program for PR and PP would have three areas: 1) safeguards and physical protection technology R and D for each GIF system; 2) formulation of PR and PP criteria and metrics; and 3) evaluation of the criteria and metrics. To cover these R and D items, the PR and PP Working Group (PRPPWG) was formed in late 2002 and has since developed a methodology for PR and PP evaluation. In a succession of revisions beginning in 2004, consensus was achieved amongst all participating GIF countries and related organizations (i.e., IAEA and EU), and Revision 6 of the methodology report was approved by GIF for open distribution in 2011. The paper describes in detail the methodology developed by the PRPPWG and discusses its applicability to the sodium-cooled fast reactor (SFR) fuel cycle with pyro processing currently under development in Korea.

Robert Alexy's Rules Ponderation and Narciso Baez's Theory Of Double Size of Human Rights in Analysis of Rights in Conflict Infanticide Concrete Case in Indigenous Villages

OpenAIRE

Rogério Gesta Leal; Fabio Biasi Pavão

2015-01-01

O presente artigo tem por objetivo analisar o tema da colisão de princípios e direitos fundamentais sob o prisma da teoria de Robert Alexy e de reflexões sobre a dupla dimensão dos direitos humanos de Narciso Leandro Xavier Baez. Para tanto, propõe uma análise dos conceitos elaborados por Robert Alexy sobre normas e princípios e situações de conflitos entre direitos. Alexy propõe regras de ponderação como alternativa à solução de conflitos entre princípios, proporcionando a prevalência de um ...

Robert Mandell: a pioneer and giant in the art and science of contact lenses.

Science.gov (United States)

Polse, Kenneth A

2008-10-01

Robert B. Mandell is the quintessential modern clinical scientist. Over his long academic career, he has pioneered many advances in contact lens practice, ranging from a more complete understanding of corneal shape to the effects of contact lenses on corneal health. His classic text, Contact Lens Practice, first published in 1965, was reprinted 14 times in four editions up to 1988. Mandell's contributions to the advancement of the profession of optometry have always been characterized by a genuine concern for the patient and a steadfast belief that his research must have relevance to the practice of optometry.

Familial CJD Associated PrP Mutants within Transmembrane Region Induced Ctm-PrP Retention in ER and Triggered Apoptosis by ER Stress in SH-SY5Y Cells

Science.gov (United States)

Wang, Xin; Shi, Qi; Xu, Kun; Gao, Chen; Chen, Cao; Li, Xiao-Li; Wang, Gui-Rong; Tian, Chan; Han, Jun; Dong, Xiao-Ping

2011-01-01

Background Genetic prion diseases are linked to point and inserted mutations in the prion protein (PrP) gene that are presumed to favor conversion of the cellular isoform of PrP (PrPC) to the pathogenic one (PrPSc). The pathogenic mechanisms and the subcellular sites of the conversion are not completely understood. Here we introduce several PRNP gene mutations (such as, PrP-KDEL, PrP-3AV, PrP-A117V, PrP-G114V, PrP-P102L and PrP-E200K) into the cultured cells in order to explore the pathogenic mechanism of familial prion disease. Methodology/Principal Findings To address the roles of aberrant retention of PrP in endoplasmic reticulum (ER), the recombinant plasmids expressing full-length human PrP tailed with an ER signal peptide at the COOH-terminal (PrP-KDEL) and PrP with three amino acids exchange in transmembrane region (PrP-3AV) were constructed. In the preparations of transient transfections, 18-kD COOH-terminal proteolytic resistant fragments (Ctm-PrP) were detected in the cells expressing PrP-KDEL and PrP-3AV. Analyses of the cell viabilities in the presences of tunicamycin and brefeldin A revealed that expressions of PrP-KDEL and PrP-3AV sensitized the transfected cells to ER stress stimuli. Western blots and RT-PCR identified the clear alternations of ER stress associated events in the cells expressing PrP-KDEL and PrP-3AV that induced ER mediated apoptosis by CHOP and capase-12 apoptosis pathway. Moreover, several familial CJD related PrP mutants were transiently introduced into the cultured cells. Only the mutants within the transmembrane region (G114V and A117V) induced the formation of Ctm-PrP and caused the ER stress, while the mutants outside the transmembrane region (P102L and E200K) failed. Conclusions/Significance The data indicate that the retention of PrP in ER through formation of Ctm-PrP results in ER stress and cell apoptosis. The cytopathic activities caused by different familial CJD associated PrP mutants may vary, among them the mutants

Familial CJD associated PrP mutants within transmembrane region induced Ctm-PrP retention in ER and triggered apoptosis by ER stress in SH-SY5Y cells.

Directory of Open Access Journals (Sweden)

Xin Wang

Full Text Available BACKGROUND: Genetic prion diseases are linked to point and inserted mutations in the prion protein (PrP gene that are presumed to favor conversion of the cellular isoform of PrP (PrP(C to the pathogenic one (PrP(Sc. The pathogenic mechanisms and the subcellular sites of the conversion are not completely understood. Here we introduce several PRNP gene mutations (such as, PrP-KDEL, PrP-3AV, PrP-A117V, PrP-G114V, PrP-P102L and PrP-E200K into the cultured cells in order to explore the pathogenic mechanism of familial prion disease. METHODOLOGY/PRINCIPAL FINDINGS: To address the roles of aberrant retention of PrP in endoplasmic reticulum (ER, the recombinant plasmids expressing full-length human PrP tailed with an ER signal peptide at the COOH-terminal (PrP-KDEL and PrP with three amino acids exchange in transmembrane region (PrP-3AV were constructed. In the preparations of transient transfections, 18-kD COOH-terminal proteolytic resistant fragments (Ctm-PrP were detected in the cells expressing PrP-KDEL and PrP-3AV. Analyses of the cell viabilities in the presences of tunicamycin and brefeldin A revealed that expressions of PrP-KDEL and PrP-3AV sensitized the transfected cells to ER stress stimuli. Western blots and RT-PCR identified the clear alternations of ER stress associated events in the cells expressing PrP-KDEL and PrP-3AV that induced ER mediated apoptosis by CHOP and caspase-12 apoptosis pathway. Moreover, several familial CJD related PrP mutants were transiently introduced into the cultured cells. Only the mutants within the transmembrane region (G114V and A117V induced the formation of Ctm-PrP and caused the ER stress, while the mutants outside the transmembrane region (P102L and E200K failed. CONCLUSIONS/SIGNIFICANCE: The data indicate that the retention of PrP in ER through formation of Ctm-PrP results in ER stress and cell apoptosis. The cytopathic activities caused by different familial CJD associated PrP mutants may vary, among them

Obituary: Robert H. Koch (1929-2010)

Science.gov (United States)

Koch, Joanne; Corcoran, Michael; Holenstein, Bruce; Sion, Edward

2011-12-01

Robert H. Koch, emeritus professor of astronomy and astrophysics at the University of Pennsylvania, passed away at his home in Ardmore, Pennsylvania on 11 October 2010 after a brief illness. Bob was 80 years old and remained sharp and intellectually engaged with the astronomical community up until the onset of complications from a brain tumor. Bob was born in York, Pennsylvania on 19 December 1929, and graduated from York Catholic High School in 1947. He attended the University of Pennsylvania on a senatorial scholarship, graduating in 1951. After two years in the United States Army, he enrolled in graduate school at the University of Pennsylvania, doing his doctoral research on the photoelectric photometry of R CMa, AO Cas, AS Eri, and XY Leo at the Steward Observatory, University of Arizona in Tucson. Bob would continue this exploration of close binary stars, their atmospheres and interactions, for the rest of his career. Bob met his future spouse, Joanne C. Underwood, while in graduate school in 1957 and they were married in 1959. Bob received his PhD in astronomy in 1959 and moved to Amherst, Massachusetts, where he taught as a member of the Four College Astronomy Department until 1966. Following a year at the University of New Mexico in Albuquerque, Bob joined the Astronomy Department at Penn, teaching and doing research there until his retirement in 1996. Bob's main interests were the study of close and eclipsing binary stars, stellar envelopes and winds, intrinsic variables, transits and occultations, and the Milky Way Galaxy, producing well over 100 refereed publications. Bob was partial to photoelectric photometry and polarimetry, conducting most of his observational research at the University of Pennsylvania Flower and Cook Observatory, and at other ground- and space-based observatories. As an international figure in the area of binary stars, Bob had widespread collaborations with scientists at other institutions, in the US and throughout the world, and

Robert S(trange McNamara (junho de 1916 a julho de 2009: a ascensão imperfeita da tecnocracia

Directory of Open Access Journals (Sweden)

Virgílio Caixeta Arraes

2009-08-01

Full Text Available o artigo trata da biografia de Robert McNamara,
falecido em julho de 2009. Ele foi Secretário de Defesa durante a gestão de John Kennedy e Lyndon
Johnson. Nesse sentido, ele foi um dos responsáveis
pelo fracasso da Guerra do Vietnã.

Electronic structures of PrBa{sub 2}Cu{sub 3}O{sub 7}, Pr{sub 2}Ba{sub 4}Cu{sub 7}O{sub 15-y}(y=0,1), and PrBa{sub 2}Cu{sub 4}O{sub 8} based on LSDA+U method

Energy Technology Data Exchange (ETDEWEB)

Tavana, A. [Magnet Research Laboratory (MRL), Department of Physics, Sharif University of Technology, Tehran (Iran); Department of Physics, University of Mohaghegh Ardabili, Ardabil (Iran); Shirazi, M.; Akhavan, M. [Magnet Research Laboratory (MRL), Department of Physics, Sharif University of Technology, Tehran (Iran)

2009-10-15

The electronic structures of PrBa{sub 2}Cu{sub 3}O{sub 7} (Pr123), Pr{sub 2}Ba{sub 4}Cu{sub 7}O{sub 15-y} (Pr247), and PrBa{sub 2}Cu{sub 4}O{sub 8} (Pr124) cuprates have been obtained using density-functional theory in the local spin density approximation plus onsite Coulomb interaction (LSDA+U). Onsite Hubbard correlation, U, has been considered for Pr-f and Cu-d orbitals and the effects of considering these correlation corrections on the Pr-O hybridizations have been inspected. Results imply that the Pr ionization state in Pr123 system is constituted from two different configurations, and the energy of the f states in these two configurations has an important role in superconductivity properties of the system. Our calculations also show that in both Pr124 and Pr247 systems, suppression of superconductivity is weaker than that in the Pr123 system. This occurs due to the weaker Pr-O bond in both Pr124 and Pr247 systems. The role of the double chain and single chain on the conduction properties of these compounds has been investigated. We have also studied the effect of oxygen deficiency in Pr247 system, which seems to revive superconductivity in this system. Investigating the hole carriers in the CuO{sub 2} plane shows a correlation between superconductivity suppression and hole decrement in the planes. (Abstract Copyright [2009], Wiley Periodicals, Inc.)

PrP mRNA and protein expression in brain and PrP(c) in CSF in Creutzfeldt-Jakob disease MM1 and VV2.

Science.gov (United States)

Llorens, Franc; Ansoleaga, Belén; Garcia-Esparcia, Paula; Zafar, Saima; Grau-Rivera, Oriol; López-González, Irene; Blanco, Rosi; Carmona, Margarita; Yagüe, Jordi; Nos, Carlos; Del Río, José Antonio; Gelpí, Ellen; Zerr, Inga; Ferrer, Isidre

2013-01-01

Creutzfeldt-Jakob disease (CJD) is a heterogenic neurodegenerative disorder associated with abnormal post-translational processing of cellular prion protein (PrP(c)). CJD displays distinctive clinical and pathological features which correlate with the genotype at the codon 129 (methionine or valine: M or V respectively) in the prion protein gene and with size of the protease-resistant core of the abnormal prion protein PrP(sc) (type 1: 20/21 kDa and type 2: 19 kDa). MM1 and VV2 are the most common sporadic CJD (sCJD) subtypes. PrP mRNA expression levels in the frontal cortex and cerebellum are reduced in sCJD in a form subtype-dependent. Total PrP protein levels and PrP(sc) levels in the frontal cortex and cerebellum accumulate differentially in sCJD MM1 and sCJD VV2 with no relation between PrP(sc) deposition and spongiform degeneration and neuron loss, but with microgliosis, and IL6 and TNF-α response. In the CSF, reduced PrP(c), the only form present in this compartment, occurs in sCJD MM1 and VV2. PrP mRNA expression is also reduced in the frontal cortex in advanced stages of Alzheimer disease, Lewy body disease, progressive supranuclear palsy, and frontotemporal lobe degeneration, but PrP(c) levels in brain varies from one disease to another. Reduced PrP(c) levels in CSF correlate with PrP mRNA expression in brain, which in turn reflects severity of degeneration in sCJD.

ER and PR expression and survival after endometrial cancer.

Science.gov (United States)

Smith, Deborah; Stewart, Colin J R; Clarke, Edward M; Lose, Felicity; Davies, Claire; Armes, Jane; Obermair, Andreas; Brennan, Donal; Webb, Penelope M; Nagle, Christina M; Spurdle, Amanda B

2018-02-01

To measure association between endometrial carcinoma ER and PR status and endometrial cancer (EC) survival, accounting for inter-observer variation. The intensity and proportion of tumor cell expression of ER and PR in ECs were assessed independently and semi-quantitatively by two pathologists using digital images of duplicate tumor tissue microarrays (TMAs). Cases with inconsistent initial assessment were reviewed and final scoring agreed. The association between overall and EC-specific survival and hormone receptor expression (intensity, proportion and combined) was assessed using Cox regression analysis. The C-index was used to evaluate model discrimination with addition of ER and PR status. Tumor ER and PR analysis was possible in 659 TMAs from 255 patients, and in 459 TMAs from 243 patients, respectively. Initial ER and PR scoring was consistent in 82% and 80% of cases, respectively. In multivariate analyses decreased ER and PR expression was associated with increased tumor-related mortality. Associations reached statistical significance for ER proportion score (P=0.05), ER intensity score (P=0.003), and PR combined score (P=0.04). Decreased expression of combined ER/PR expression was associated with poorer EC-specific survival than decreased expression of either hormone receptor alone (P=0.005). However, hormone receptor status did not significantly improve mortality prediction in individual cases. ER and PR expression combined, using cut-points that capture variation in scoring and across cores, is significantly associated with EC-specific survival in analyses adjusting for known prognostic factors. However, at the individual level, ER and PR expression does not improve mortality prediction. Copyright © 2017 Elsevier Inc. All rights reserved.

Acetylcholinesterase triggers the aggregation of PrP 106-126

International Nuclear Information System (INIS)

Pera, M.; Roman, S.; Ratia, M.; Camps, P.; Munoz-Torrero, D.; Colombo, L.; Manzoni, C.; Salmona, M.; Badia, A.; Clos, M.V.

2006-01-01

Acetylcholinesterase (AChE), a senile plaque component, promotes amyloid-β-protein (Aβ) fibril formation in vitro. The presence of prion protein (PrP) in Alzheimer's disease (AD) senile plaques prompted us to assess if AChE could trigger the PrP peptides aggregation as well. Consequently, the efficacy of AChE on the PrP peptide spanning-residues 106-126 aggregation containing a coumarin fluorescence probe (coumarin-PrP 106-126) was studied. Kinetics of coumarin-PrP 106-126 aggregation showed a significant increase of maximum size of aggregates (MSA), which was dependent on AChE concentration. AChE-PrP 106-126 aggregates showed the tinctorial and optical amyloid properties as determined by polarized light and electronic microscopy analysis. A remarkable inhibition of MSA was obtained with propidium iodide, suggesting that AChE triggers PrP 106-126 and Aβ aggregation through a similar mechanism. Huprines (AChE inhibitors) also significantly decreased MSA induced by AChE as well, unveiling the potential interest for some AChE inhibitors as a novel class of potential anti-prion drugs

Spontaneous intracranial hemorrhage and multiple intracranial aneurysms in a patient with Roberts/SC phocomelia syndrome.

Science.gov (United States)

Wang, Anthony C; Gemmete, Joseph J; Keegan, Catherine E; Witt, Cordelie E; Muraszko, Karin M; Than, Khoi D; Maher, Cormac O

2011-11-01

Roberts/SC phocomelia syndrome (RBS) is a rare but distinct genetic disorder with an autosomal recessive inheritance pattern. It has been associated with microcephaly, craniofacial malformation, cavernous hemangioma, encephalocele, and hydrocephalus. There are no previously reported cases of RBS with intracranial aneurysms. The authors report on a patient with a history of RBS who presented with a spontaneous posterior fossa hemorrhage. Multiple small intracranial aneurysms were noted on a preoperative CT angiogram. The patient underwent emergency craniotomy for evacuation of the hemorrhage. A postoperative angiogram confirmed the presence of multiple, distal small intracranial aneurysms.

LOS DERECHOS FUNDAMENTALES COMO NORMAS JURÍDICAS MATERIALES EN LA TEORÍA DE ROBERT ALEXY

Directory of Open Access Journals (Sweden)

María Dolores Pérez Jaraba

2011-12-01

ABSTRACT. The theory of the civil rights of Robert Alexy is based on a material concept of rule of law. It is two-fold. On the one hand, is defined by the traits of the principles, consistent with the idea of ??correct argument. But on the other hand, weight is still the legal validity of the rules contained civil rights, constitutional rules considered. As argued in the work, this ambiguity of the norm theory allows for different approaches Alexy, positivist and positivist, which is a sign of its theoretical richness

An experimental ‘Life’ for an experimental life : Richard Waller's biography of Robert Hooke (1705)

OpenAIRE

Moxham, Noah

2016-01-01

Richard Waller's ‘Life of Dr Robert Hooke’, prefixed to his edition of Hooke's Posthumous Works (1705), is an important source for the life of one of the most eminent members of the early Royal Society. It also has the distinction of being one of the earliest biographies of a man of science to be published in English. I argue that it is in fact the first biography to embrace the subject's natural-philosophical work as the centre of his life, and I investigate Waller's reasons for adopting thi...

Purification and Fibrillation of Full-Length Recombinant PrP

OpenAIRE

Makarava, Natallia; Baskakov, Ilia V.

2012-01-01

Misfolding and aggregation of prion protein (PrP) is related to several neurodegenerative diseases in humans such as Creutzfeldt–Jacob disease, fatal familial insomnia, and Gerstmann–Straussler–Sheinker disease. Certain applications in prion area require recombinant PrP of high purity and quality. Here, we report an experimental procedure for expression and purification of full-length mammalian PrP. This protocol has been proved to yield PrP of extremely high purity that lac...

Prion Propagation in Cells Expressing PrP Glycosylation Mutants ▿

Science.gov (United States)

Salamat, Muhammad K.; Dron, Michel; Chapuis, Jérôme; Langevin, Christelle; Laude, Hubert

2011-01-01

Infection by prions involves conversion of a host-encoded cell surface protein (PrPC) to a disease-related isoform (PrPSc). PrPC carries two glycosylation sites variably occupied by complex N-glycans, which have been suggested by previous studies to influence the susceptibility to these diseases and to determine characteristics of prion strains. We used the Rov cell system, which is susceptible to sheep prions, to generate a series of PrPC glycosylation mutants with mutations at one or both attachment sites. We examined their subcellular trafficking and ability to convert into PrPSc and to sustain stable prion propagation in the absence of wild-type PrP. The susceptibility to infection of mutants monoglycosylated at either site differed dramatically depending on the amino acid substitution. Aglycosylated double mutants showed overaccumulation in the Golgi compartment and failed to be infected. Introduction of an ectopic glycosylation site near the N terminus fully restored cell surface expression of PrP but not convertibility into PrPSc, while PrPC with three glycosylation sites conferred cell permissiveness to infection similarly to the wild type. In contrast, predominantly aglycosylated molecules with nonmutated N-glycosylation sequons, produced in cells expressing glycosylphosphatidylinositol-anchorless PrPC, were able to form infectious PrPSc. Together our findings suggest that glycosylation is important for efficient trafficking of anchored PrP to the cell surface and sustained prion propagation. However, properly trafficked glycosylation mutants were not necessarily prone to conversion, thus making it difficult in such studies to discern whether the amino acid changes or glycan chain removal most influences the permissiveness to prion infection. PMID:21248032

Bioetanooli saab prügist / Mette Hedegaard Thomsen ; interv. Sten-Aleks Pihlak

Index Scriptorium Estoniae

Thomsen, Mette Hedegaard

2008-01-01

Taani Tehnikaülikooli Riso laboratooriumi teaduri Mette Hedegaard Thomseni sõnul suudab teise põlvkonna bioetanoolitehas teha kütust kõikvõimalikest jäätmetest ning on samas palju loodussõbralikum. Kommenteerib Robert Antropov

Glycan-deficient PrP stimulates VEGFR2 signaling via glycosaminoglycan.

Science.gov (United States)

Gao, Zhenxing; Zhang, Huixia; Hu, Fei; Yang, Liheng; Yang, Xiaowen; Zhu, Ying; Sy, Man-Sun; Li, Chaoyang

2016-06-01

Whether the two N-linked glycans are important in prion, PrP, biology is unresolved. In Chinese hamster ovary (CHO) cells, the two glycans are clearly not important in the cell surface expression of transfected human PrP. Compared to fully-glycosylated PrP, glycan-deficient PrP preferentially partitions to lipid raft. In CHO cells glycan-deficient PrP also interacts with glycosaminoglycan (GAG) and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in VEGFR2 activation and enhanced Akt phosphorylation. Accordingly, CHO cells expressing glycan-deficient PrP lacking the GAG binding motif or cells treated with heparinase to remove GAG show diminished Akt signaling. Being in lipid raft is critical, chimeric glycan-deficient PrP with CD4 transmembrane and cytoplasmic domains is absent in lipid raft and does not activate Akt signaling. CHO cells bearing glycan-deficient PrP also exhibit enhanced cellular adhesion and migration. Based on these findings, we propose a model in which glycan-deficient PrP, GAG, and VEGFR2 interact, activating VEGFR2 and resulting in changes in cellular behavior. Copyright © 2016 Elsevier Inc. All rights reserved.

Pathogenesis of PR3-ANCA associated vasculitis

NARCIS (Netherlands)

Kallenberg, C. G. M.

2008-01-01

Wegener's Granulomatosis (WG) is closely associated with antineutrophil cytoplasmic autoantibodies (ANCA), particularly those directed to proteinase 3 (PR3). ANCA directed to myeloperoxidase (MPO) are associated with microscopic polyangiitis (MPA) and the Churg Strauss syndrome. PR3-ANCA associated

Comparative NMR study of nPrBTP and iPrBTP

Energy Technology Data Exchange (ETDEWEB)

Adam, C.; Muellich, U.; Geist, A.; Geckeis, H. [Karlsruhe Institute of Technology - KIT, Institute for Nuclear Waste Disposal - INE, Herrmann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Rohde, V. [Fraunhofer Institute for Chemical Technology - ICT, Environmental Engineering, Joseph-von-Fraunhofer-Str. 7, 76327 Pfinztal (Germany); Kaden, P. [Helmholtz-Zentrum Dresden - Rossendorf e. V., Institute of Resource Ecology, Bautzner Landstrasse 400, 01328 Dresden (Germany); Panak, P.J. [Karlsruhe Institute of Technology - KIT, Institute for Nuclear Waste Disposal - INE, Herrmann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); University of Heidelberg, Department of Physical Chemistry, Im Neuenheimer Feld 253, 69120 Heidelberg (Germany)

2016-07-01

Bis-triazinyl-pyridine type ligands are important extracting agents for separating trivalent actinide ions from trivalent lanthanides. The alkyl substituents on the lateral triazine rings have a significant effect on the stability of the ligand against hydrolysis and radiolysis. Furthermore they influence solubility, extraction behaviour and selectivity. TRLFS and extraction studies suggest differences in complexation and extraction behaviour of BTP ligands bearing iso-propyl or n-propyl substituents, respectively. As NMR studies allow insight into the metal-ligand bonding, we conducted NMR studies on a range of {sup 15}N-labelled nPrBTP and iPrBTP Ln(III) and Am(III) complexes. Our results show that no strong change in the metal-ligand bonding occurs, thus excluding electronic reasons for differences in complexation behaviour, extraction kinetics and selectivity. This supports mechanistic reasons for the observed differences. (authors)

Advancing tendencies? PR leadership, general leadership, and leadership pedagogy

OpenAIRE

McKie, D; Willis, P

2014-01-01

What are the best ways to advance PR leadership? In exploring answers, we consider the last two decades of PR literature and identify two main tendencies. We link those two with general leadership literature and practices, as well as with literature on leadership pedagogy. We conclude that, rather than recent moves to look within the field, without self-reflection, to existing PR perspectives and figures for solutions, looking outwards has greater potential to transform not only the PR leader...

Ten years experience of PR

International Nuclear Information System (INIS)

Dobak, Dobroslav

2002-01-01

This paper is an effort to summarize the way Slovak Bohunice NPP has gone through since the historical change in the Middle and Eastern European countries. Milestones on the way were: 1989 - change of political system; increasing interest of the public appearance; creation of work capacities - personnel and technical; education/exchange with Western countries; 1994 - establishment of Foreign Affairs and PR Department reporting directly to the NPP manager; application of various approaches, some observed from other countries; creation of utility policy - place of PR in the company; establishment of QA system - description of PR activities, goals, interlinks etc.; annual planning process including activities, finance, education (training). Lessons learned are: the NPP managers were not prepared; the public was not (and still is not) prepared to obtain specific information; education is crucial in opinion winning; simple overtake of methods from others is not always applicable; strategy and feedback are necessary. Special case was the early closure Bohunice V1 NPP

A phase I trial of PR-104, a pre-prodrug of the bioreductive prodrug PR-104A, given weekly to solid tumour patients

International Nuclear Information System (INIS)

McKeage, Mark J; Gu, Yongchuan; Wilson, William R; Hill, Andrew; Amies, Karen; Melink, Teresa J; Jameson, Michael B

2011-01-01

The phosphate ester PR-104 is rapidly converted in vivo to the alcohol PR-104A, a nitrogen mustard prodrug that is metabolised to hydroxylamine (PR-104H) and amine (PR-104M) DNA crosslinking agents by one-electron reductases in hypoxic cells and by aldo-keto reductase 1C3 independently of oxygen. In a previous phase I study using a q 3 week schedule of PR-104, the maximum tolerated dose (MTD) was 1100 mg/m 2 and fatigue, neutropenic fever and infection were dose-limiting. The primary objective of the current study was to determine the dose-limiting toxicity (DLT) and MTD of weekly PR-104. Patients with advanced solid tumours received PR-104 as a 1-hour intravenous infusion on days 1, 8 and 15 every 28 days with assessment of pharmacokinetics on cycle 1 day 1. Twenty-six patients (pts) were enrolled (16 male/10 female; median age 58 yrs, range 30 to 70 yrs) who had received a median of two prior chemotherapy regimens (range, 0 to 3) for melanoma (8 pts), colorectal or anal cancer (3 pts), NSCLC (3 pts), sarcoma (3 pts), glioblastoma (2 pts), salivary gland tumours (2 pts) or other solid tumours (5 pts). PR-104 was administered at 135 mg/m 2 (3 pts), 270 mg/m 2 (6 pts), 540 mg/m 2 (6 pts), 675 mg/m 2 (7 pts) and 900 mg/m 2 (4 pts) for a median of two treatment cycles (range, 1 to 7 cycles) and five infusions (range, 1 to 18) per patient. Dose-limiting toxicities (DLTs) during cycle one included grade four thrombocytopenia at 540 mg/m 2 (1 of 6 pts) and grade four thrombocytopenia and neutropenia at 900 mg/m 2 (2 of 4 pts). At an intermediate dose of 675 mg/m 2 , there were no DLTs among a total of seven patients given 12 treatment cycles but all experienced moderate to severe (grade 2 to 4) haematological toxicity. Thrombocytopenia was delayed in its onset and nadir, and its recovery was protracted and incomplete in many patients. There were no complete or partial tumour responses. PR-104-induced thrombocytopenia and neutropenia correlated with plasma AUC of PR-104

Number theory and modular forms papers in memory of Robert A Rankin

CERN Document Server

Ono, Ken

2003-01-01

Robert A. Rankin, one of the world's foremost authorities on modular forms and a founding editor of The Ramanujan Journal, died on January 27, 2001, at the age of 85. Rankin had broad interests and contributed fundamental papers in a wide variety of areas within number theory, geometry, analysis, and algebra. To commemorate Rankin's life and work, the editors have collected together 25 papers by several eminent mathematicians reflecting Rankin's extensive range of interests within number theory. Many of these papers reflect Rankin's primary focus in modular forms. It is the editors' fervent hope that mathematicians will be stimulated by these papers and gain a greater appreciation for Rankin's contributions to mathematics. This volume would be an inspiration to students and researchers in the areas of number theory and modular forms.

Genetic determinants of P wave duration and PR segment

NARCIS (Netherlands)

Verweij, Niek; Mateo Leach, Irene; van den Boogaard, Malou; van Veldhuisen, Dirk J.; Christoffels, Vincent M.; Hillege, Hans L.; van Gilst, Wiek H.; Barnett, Phil; de Boer, Rudolf A.; van der Harst, Pim

2014-01-01

The PR interval on the ECG reflects atrial depolarization and atrioventricular nodal delay which can be partially differentiated by P wave duration and PR segment, respectively. Genome-wide association studies have identified several genetic loci for PR interval, but it remains to be determined

Genetic Determinants of P Wave Duration and PR Segment

NARCIS (Netherlands)

Verweij, Niek; Mateo Leach, Irene; van den Boogaard, Malou; van Veldhuisen, Dirk J.; Christoffels, Vincent M.; Hillege, Hans L.; van Gilst, Wiek H.; Barnett, Phil; de Boer, Rudolf A.; van der Harst, Pim

Background-The PR interval on the ECG reflects atrial depolarization and atrioventricular nodal delay which can be partially differentiated by P wave duration and PR segment, respectively. Genome-wide association studies have identified several genetic loci for PR interval, but it remains to be

Antimicrobial and immunomodulatory activities of PR-39 derived peptides.

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Edwin J A Veldhuizen

Full Text Available The porcine cathelicidin PR-39 is a host defence peptide that plays a pivotal role in the innate immune defence of the pig against infections. Besides direct antimicrobial activity, it is involved in immunomodulation, wound healing and several other biological processes. In this study, the antimicrobial- and immunomodulatory activity of PR-39, and N- and C-terminal derivatives of PR-39 were tested. PR-39 exhibited an unexpected broad antimicrobial spectrum including several Gram positive strains such as Bacillus globigii and Enterococcus faecalis. Of organisms tested, only Staphylococcus aureus was insensitive to PR-39. Truncation of PR-39 down to 15 (N-terminal amino acids did not lead to major loss of activity, while peptides corresponding to the C-terminal part of PR-39 were hampered in their antimicrobial activity. However, shorter peptides were all much more sensitive to inhibition by salt. Active peptides induced ATP leakage and loss of membrane potential in Bacillus globigii and Escherichia coli, indicating a lytic mechanism of action for these peptides. Finally, only the mature peptide was able to induce IL-8 production in porcine macrophages, but some shorter peptides also had an effect on TNF-α production showing differential regulation of cytokine induction by PR-39 derived peptides. None of the active peptides showed high cytotoxicity highlighting the potential of these peptides for use as an alternative to antibiotics.

Antimicrobial and Immunomodulatory Activities of PR-39 Derived Peptides

Science.gov (United States)

Veldhuizen, Edwin J. A.; Schneider, Viktoria A. F.; Agustiandari, Herfita; van Dijk, Albert; Tjeerdsma-van Bokhoven, Johanna L. M.; Bikker, Floris J.; Haagsman, Henk P.

2014-01-01

The porcine cathelicidin PR-39 is a host defence peptide that plays a pivotal role in the innate immune defence of the pig against infections. Besides direct antimicrobial activity, it is involved in immunomodulation, wound healing and several other biological processes. In this study, the antimicrobial- and immunomodulatory activity of PR-39, and N- and C-terminal derivatives of PR-39 were tested. PR-39 exhibited an unexpected broad antimicrobial spectrum including several Gram positive strains such as Bacillus globigii and Enterococcus faecalis. Of organisms tested, only Staphylococcus aureus was insensitive to PR-39. Truncation of PR-39 down to 15 (N-terminal) amino acids did not lead to major loss of activity, while peptides corresponding to the C-terminal part of PR-39 were hampered in their antimicrobial activity. However, shorter peptides were all much more sensitive to inhibition by salt. Active peptides induced ATP leakage and loss of membrane potential in Bacillus globigii and Escherichia coli, indicating a lytic mechanism of action for these peptides. Finally, only the mature peptide was able to induce IL-8 production in porcine macrophages, but some shorter peptides also had an effect on TNF-α production showing differential regulation of cytokine induction by PR-39 derived peptides. None of the active peptides showed high cytotoxicity highlighting the potential of these peptides for use as an alternative to antibiotics. PMID:24755622

Programa Pró-Letramento : interface entre formação continuada, prática docente e ensino da leitura

OpenAIRE

Lúcia da Silva Cabral, Maria

2009-01-01

Essa pesquisa visa analisar os impactos da Formação Continuada na prática docente dos professores das séries iniciais do Ensino Fundamental no eixo do ensino da leitura, no Programa Pró-Letramento Alfabetização e Linguagem. Para realizar, então, esta investigação qualitativa, observamos os processos de Formação Continuada dos orientadores de estudos e também dos professores no programa mencionado. Realizamos também observação da prática de duas professoras em turmas iniciais ...

Desnutrição e práticas pré-escolares de leitura e escrita

Directory of Open Access Journals (Sweden)

Sandra Maria Sawaya

2013-01-01

Full Text Available O presente artigo procura dar conta de alguns dos resultados de uma pesquisa realizada com um grupo de treze crianças de três a cinco anos em uma instituição de educação infantil que atende crianças com desnutrição primária. Um dos objetivos do estudo foi verificar que relações e práticas de leitura e escrita se desenvolvem entre esse grupo de crianças e seu professor na pré-escola. Os dados obtidos corroboram estudos que apontam a necessidade de revisar os pressupostos das políticas educacionais de que as crianças de camadas populares trazem para a instituição de ensino problemas de aprendizagem devido a atrasos no desenvolvimento linguístico e cognitivo em decorrência da ausência de práticas de leitura e escrita em seu universo sociocultural.

Aprendizagem como/na prática

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Jean Lave

2015-12-01

Full Text Available ResumoEste artigo considera como o estudo da cultura e da aprendizagem pode ser de particular relevância para o campo da antropologia sociocultural em geral. O termo mais importante na expressão “cultura & aprendizagem” talvez seja o logograma “&” – ou seja, coloca-se a questão sobre o que conecta cultura e aprendizagem, perguntando-se como esses termos estão relacionados. Como devemos compreender cultura e aprendizagem como instâncias produtoras delas próprias, e uma da outra, na prática? Recalibrando em termos relacionais, podemos dizer que não é possível abordar a “aprendizagem” ou “cultura e aprendizagem” sem o seu emaranhamento na vida político-econômica, nas lutas e disputas históricas, em suas coerências e incoerências, e na produção relacional e histórica da vida cotidiana. Através das lentes da teoria da prática social, os estudos etnográficos sobre aprendizagem na prática oferecem diferentes entendimentos sobre como certa vida e certas disputas e incoerências são produzidas.

Essay in honor of Robert Motherwell's centenary: “temporalized form”: mediating Romanticism and American Expressionism—Robert Motherwell, Henri Bergson, and the ontological origins of abstraction around 18001

Directory of Open Access Journals (Sweden)

Manfred Milz

2016-02-01

Full Text Available The influence of process metaphysics on the development of abstraction between 1800 and the second half of the 20th century can best be exemplified with the case of the American Expressionist painter and theoretician Robert Motherwell (1915–1991. Taking as its starting point Motherwell's exposure to the History of Idea of Romanticism, Arthur O. Lovejoy's yearlong seminar at Harvard (1937–38, the artist's affinity with fluid forms through motion brushstrokes in Romanticist painting is analyzed as a preformative stage of his own transitory creations. This is done by structural comparison between Motherwell's written reflections and Romanticist art theory. Motherwell's specific perception through Bergson's and Whitehead's lens of immanence and multiplicity, I argue, resonates Lovejoy's principle of “Romantic Evolutionism,” in its turn from being to becoming, derived from the philosophies of the Spiritualist Maine de Biran and the Idealist–Empiricist George Berkeley.

Interferon-Stimulated Genes Are Transcriptionally Repressed by PR in Breast Cancer.

Science.gov (United States)

Walter, Katherine R; Goodman, Merit L; Singhal, Hari; Hall, Jade A; Li, Tianbao; Holloran, Sean M; Trinca, Gloria M; Gibson, Katelin A; Jin, Victor X; Greene, Geoffrey L; Hagan, Christy R

2017-10-01

The progesterone receptor (PR) regulates transcriptional programs that drive proliferation, survival, and stem cell phenotypes. Although the role of native progesterone in the development of breast cancer remains controversial, PR clearly alters the transcriptome in breast tumors. This study identifies a class of genes, Interferon (IFN)-stimulated genes (ISGs), potently downregulated by ligand-activated PR which have not been previously shown to be regulated by PR. Progestin-dependent transcriptional repression of ISGs was observed in breast cancer cell line models and human breast tumors. Ligand-independent regulation of ISGs was also observed, as basal transcript levels were markedly higher in cells with PR knockdown. PR repressed ISG transcription in response to IFN treatment, the canonical mechanism through which these genes are activated. Liganded PR is robustly recruited to enhancer regions of ISGs, and ISG transcriptional repression is dependent upon PR's ability to bind DNA. In response to PR activation, key regulatory transcription factors that are required for IFN-activated ISG transcription, STAT2 and IRF9, exhibit impaired recruitment to ISG promoter regions, correlating with PR/ligand-dependent ISG transcriptional repression. IFN activation is a critical early step in nascent tumor recognition and destruction through immunosurveillance. As the large majority of breast tumors are PR positive at the time of diagnosis, PR-dependent downregulation of IFN signaling may be a mechanism through which early PR-positive breast tumors evade the immune system and develop into clinically relevant tumors. Implications: This study highlights a novel transcriptional mechanism through which PR drives breast cancer development and potentially evades the immune system. Mol Cancer Res; 15(10); 1331-40. ©2017 AACR . ©2017 American Association for Cancer Research.

Análisis Epistemológico del Modelo de Aprendizaje Acumulativo de Robert Gagne

OpenAIRE

Anibal Meza; Carmen Lazarte

1993-01-01

Se reseñan aspectos fundamentales de la psicología del aprendizaje de Robert Gagné, destacando sus bases filosóficas (positivismo y pragmatismo) y científicas ( conductismo y modelo de procesamiento de la información) y luego se evalúan dichos aspectos desde una perspectiva epistemológica en términos de sus <

Wearing the crown of Solomon? Chief Justice Roberts and the Affordable Care Act "tax".

Science.gov (United States)

Muise, Robert J; Yerushalmi, David

2013-04-01

Attempting to play the role of King Solomon in his PPACA decision, Chief Justice John Roberts split the baby perversely by ruling it was not a tax under the Anti-Injunction Act, which would have likely deprived the Court of jurisdiction to hear this pre-enforcement challenge to the individual mandate, but it was a tax for taxing and spending purposes even though Congress said it was a "penalty" and not a tax. And the Chief Justice had to twist further his "wisdom" to hold that it was not an unconstitutional direct tax, even though that is exactly what it is, if it is a tax in the first instance.

The remarkable vision of Robert Hooke (1635-1703): first observer of the microbial world.

Science.gov (United States)

Gest, Howard

2005-01-01

Robert Hooke played important roles in the early development of the Royal Society of London. As Curator of Experiments of the Society, he became a pioneering microscopist, prolific inventor, astronomer, geologist, architect, and an effective surveyor of the City of London following the Great Fire of 1666. Hooke's Micrographia (1665) revealed the microscopic structures of numerous biological and inorganic objects and became an important source of information for later studies. Aside from the body of detailed observations reported and depicted in Micrographia, the Preface is in itself an extraordinary document that exhibits Hooke's fertile mind, philosophical insights, and rare ability to look into the future.

Robert Boyle, Transmutation, and the History of Chemistry before Lavoisier: A Response to Kuhn.

Science.gov (United States)

Newman, William R

2014-01-01

In an influential article of 1952, Thomas Kuhn argued that Robert Boyle had little or no influence on the subsequent development of chemistry. This essay challenges Kuhn's view on two fronts. First, it shows that Johann Joachim Becher developed his hierarchical matter theory under the influence of Boyle and then transmitted it to the founder of the phlogiston theory, G. E. Stahl. Second, this essay argues that transmutational matter theories were not necessarily opposed to the existence of stable chemical species, pace Kuhn. Boyle's corpuscular theory descended largely from the tradition of "chymical atomism," which often advocated both chrysopoeia and the reality of robust chemical substances.

O sentido objetivo da prática administrativa

Directory of Open Access Journals (Sweden)

Paulo Tromboni Nascimento

Full Text Available Este artigo examina o sentido da prática administrativa e defende a tese de que é objetivo. A discussão busca a caracterização geral do objeto de investigação. No lugar do objeto das ciências da natureza, inanimado e isolado do sujeito, entra a prática administrativa com sentido objetivo derivado da lógica da situação objetiva do administrador no contexto organizacional. Vale dizer derivado dos propósitos, da rede estruturada de relações sociais e do sistema de práticas da organização. O que torna real a sua axiologia referenciada na eficiência e eficácia da ação, além de fazer da prática administrativa um fator de regulação e mudança controlada da organização. Examinar cientificamente uma prática é criar as condições para mudá-la via uma dialética da descrição, explicação e prescrição. A filosofia da prática é proposta como pressuposto geral da pesquisa científica em administração.

Robert Boyle and the representation of imperceptible entities.

Science.gov (United States)

Wragge-Morley, Alexander

2018-03-01

In this essay, I examine Robert Boyle's strategies for making imperceptible entities accessible to the senses. It is well known that, in his natural philosophy, Boyle confronted the challenge of making imperceptible particles of matter into objects of sensory experience. It has never been noted, however, that Boyle confronted a strikingly similar challenge in his natural theology - he needed to make an equally imperceptible God accessible to the senses. Taking this symmetrical difficulty as my starting point, I propose a new approach to thinking about the interconnections between Boyle's natural philosophy and natural theology. For the most part, studies of science and religion in the early modern period work by seeking out the influence of explicitly stated religious beliefs on scientific ideas. I argue, by contrast, that we need to focus on Boyle's representational practices, using his attempts to represent imperceptible entities as a means of uncovering metaphysical and theological presuppositions that he did not always articulate when stating his religious beliefs. With new interpretations of both A Discourse of Things Above Reason (1681) and Some Physico-Theological Considerations about the Possibility of the Resurrection (1675), I show that there were crucial similarities between Boyle's practices for representing both God and atoms. I go on to show, moreover, that Boyle used these practices to enact an ontological stance at odds with one of his most important professed beliefs.

The PR in PN for Education Associations. PR Bookshelf, No. 3.

Science.gov (United States)

National Education Association, Washington, DC.

This booklet presents suggestions and guidelines for the effective use of public relations (PR) techniques during professional negotiations (PN) among teachers, administrators, and boards of education. Introductory sections present the National Education Association (NEA) position regarding professional negotiation and grievance procedures and…

Cinema and the Great War - Andrew Kelly, 1997. History by Hollywood. The use and abuse of the American past - Robert Brant Toplin, 1996

NARCIS (Netherlands)

Kester, Bernadette

1998-01-01

textabstractReview of: Cinema and the Great War. Andrew Kelly, Londen, New York (Routledge), 1997, 219 p.History by Hollywood. The use and abuse of the American past. Robert Brant Toplin, Chicago (Urbana), 1996, 267 p.

Low fraction of the 222K PrP variant in the protease-resistant moiety of PrPres in heterozygous scrapie positive goats.

Science.gov (United States)

Mazza, Maria; Guglielmetti, Chiara; Ingravalle, Francesco; Brusadore, Sonia; Langeveld, Jan P M; Ekateriniadou, Loukia V; Andréoletti, Olivier; Casalone, Cristina; Acutis, Pier Luigi

2017-07-01

The presence of lysine (K) at codon 222 has been associated with resistance to classical scrapie in goats, but few scrapie cases have been identified in 222Q/K animals. To investigate the contribution of the 222K variant to PrPres formation in natural and experimental Q/K scrapie cases, we applied an immunoblotting method based on the use of two different monoclonal antibodies, F99/97.6.1 and SAF84, chosen for their different affinities to 222K and 222Q PrP variants. Our finding that PrPres seems to be formed nearly totally by the 222Q variant provides evidence that the 222K PrP variant confers resistance to conversion to PrPres formation and reinforces the view that this mutation has a protective role against classical scrapie in goats.

PrEP implementation research in Africa: what is new?

Science.gov (United States)

Cowan, Frances M; Delany-Moretlwe, Sinead; Sanders, Eduard J; Mugo, Nelly R; Guedou, Fernand A; Alary, Michel; Behanzin, Luc; Mugurungi, Owen; Bekker, Linda-Gail

2016-01-01

Of the two million new HIV infections in adults in 2014, 70% occurred in sub-Saharan Africa. Several African countries have already approved guidelines for pre-exposure prophylaxis (PrEP) for individuals at substantial risk of HIV as part of combination HIV prevention but key questions remain about how to identify and deliver PrEP to those at greatest need. Throughout the continent, individuals in sero-discordant relationships, and members of key populations (sex workers, men who have sex with men (MSM), transgender women and injection drug users) are likely to benefit from the availability of PrEP. In addition, adolescent girls and young women (AGYW) are at substantial risk in some parts of the continent. It has been estimated that at least three million individuals in Africa are likely to be eligible for PrEP according to WHO's criteria. Tens of demonstration projects are planned or underway across the continent among a range of countries, populations and delivery settings. In each of the target populations, there are overarching issues related to (i) creating demand for PrEP, (ii) addressing supply-side issues and (iii) providing appropriate and tailored adherence support. Critical for creating demand for PrEP is the normalization of HIV prevention. Community-level interventions which engage opinion leaders as well as empowerment interventions for those at highest risk will be key. Critical to supply of PrEP is that services are accessible for all, including for stigmatized populations. Establishing accessible integrated services provides the opportunity to address other public health priorities including the unmet need for HIV testing, contraception and sexually transmitted infections treatment. National policies need to include minimum standards for training and quality assurance for PrEP implementation and to address supply chain issues. Adherence support needs to recognize that social and structural factors are likely to have an important influence

A Closer Look at Racism and Heterosexism in Medical Students' Clinical Decision-Making Related to HIV Pre-Exposure Prophylaxis (PrEP): Implications for PrEP Education.

Science.gov (United States)

Calabrese, Sarah K; Earnshaw, Valerie A; Krakower, Douglas S; Underhill, Kristen; Vincent, Wilson; Magnus, Manya; Hansen, Nathan B; Kershaw, Trace S; Mayer, Kenneth H; Betancourt, Joseph R; Dovidio, John F

2018-04-01

Social biases among healthcare providers could limit PrEP access. In this survey study of 115 US medical students, we examined associations between biases (racism and heterosexism) and PrEP clinical decision-making and explored prior PrEP education as a potential buffer. After viewing a vignette about a PrEP-seeking MSM patient, participants reported anticipated patient behavior (condomless sex, extra-relational sex, and adherence), intention to prescribe PrEP to the patient, biases, and background characteristics. Minimal evidence for racism affecting clinical decision-making emerged. In unadjusted analyses, heterosexism indirectly affected prescribing intention via all anticipated behaviors, tested as parallel mediators. Participants expressing greater heterosexism more strongly anticipated increased risk behavior and adherence problems, which were associated with lower prescribing intention. The indirect effect via condomless sex remained significant adjusting for background characteristics. Prior PrEP education did not buffer any indirect effects. Heterosexism may compromise PrEP provision to MSM and should be addressed in PrEP-related medical education.

Research into the evaluation of PR activities in companies from Serbia

Directory of Open Access Journals (Sweden)

Milan Nikolic

2016-04-01

Full Text Available This paper presents the results of a research into the volume, type and quality of the evaluation of public relations activities in companies in Serbia. The survey was conducted via a web survey. The responses were collected from 50 PR service managers from 50 companies in Serbia. The results are presented through descriptive statistics and correlation analysis where some of the observed sizes of the connection were analyzed. The main conclusions can be summarized as follows: PR functions are often not assigned sufficient importance in companies in Serbia; the evaluation of PR activity is slightly neglected compared to other PR activities; intensive and continuous evaluation of the performances of PR activities increases the likelihood of the complete PR function of the company being successful; companies that are not so successful use evaluation less than successful companies; the evaluation of PR activities is mostly done through a method for measuring quantity; the main problems in the evaluation of PR activities are lack of time and money. The evaluation of PR activities in companies in Serbia can be improved through a greater understanding on the part of top managers, and also by hiring additional PR practitioners.

Paramagnetic probes to study PrNi5?

International Nuclear Information System (INIS)

Hutchinson, W.D.; Harker, S.J.; Stewart, G.A.; Chaplin, D.H.; Kaplan, N.

1996-01-01

The Van-Vleck paramagnet PrNi 5 has been the focus of many studies in the past as a result of its usefulness as a nuclear cooling agent. Extensive continuous wave praseodymium NMR measurements have been carried out on this compound. However pulsed NMR and therefore precise relaxation measurements particularly at mK temperatures have proved elusive. In this work we have proposed to use radiative gamma-ray detection to indirectly measure Pr NMR in PrNi 5 via cross relaxation to suitable paramagnetic impurity probes placed at Ni lattice sites. 57 Co was chosen as the most compatible nuclear orientation isotope with an appropriate nuclear g-factor. The choice of 57 Co also allows the use of Moessbauer spectroscopy to check the site occupancy. This poster details the production of a 57 Co doped PrNi 5 single crystal specimen including the specimen preparation problems encountered, 57 Fe Moessbauer and preliminary nuclear orientation measurements

Luminescence of the SrCl2:Pr crystals under high-energy excitation

International Nuclear Information System (INIS)

Antonyak, O.T.; Voloshinovskii, A.S.; Vistovskyy, V.V.; Stryganyuk, G.B.; Kregel, O.P.

2014-01-01

The present research was carried out in order to elucidate the mechanisms of energy transfer from the crystal lattice to Pr 3+ ions in SrCl 2 . The luminescence excitation and emission spectra as well as luminescence kinetics of the SrCl 2 :Pr single crystals containing 0.2 mol% Pr were investigated at 300 and 10 K using the vacuum ultraviolet (VUV) synchrotron radiation. The X-ray excited luminescence spectra of the SrCl 2 :Pr (C Pr =0.2 and 0.5 mol%) and SrCl 2 :Pr, K (C Pr =1.5 mol%; C K =1.5 mol%) crystals were studied at 294 and 80 K. Under optical excitation of the samples in the Pr 3+ absorption bands, there were observed five fast ultraviolet emissions assigned to the 4f 1 5d→4f 2 transitions, and two long-wave bands corresponding to the f–f transitions. Furthermore, the intrinsic emission bands of SrCl 2 were observed at 10 K. The X-ray excited luminescence spectrum of the SrCl 2 :Pr crystal containing 0.2 mol% Pr, besides intrinsic emission band near 400 nm, has got a long-wave band at about 490 nm of the Pr 3+ centers. There were not observed any emission bands of the Pr 3+ centers corresponding to the 4f 1 5d–4f 2 transitions in the X-ray excited luminescence spectrum of the SrCl 2 :Pr crystal. The possible mechanisms of energy transfer from the SrCl 2 matrix to the Pr 3+ centers are discussed. -- Highlights: • Spectral-luminescent properties of SrCl 2 :Pr have been investigated. • The identification of emission 4f–4f and 5d–4f bands of Pr 3+ ions was performed. • Adding of potassium prevents clustering of the Pr 3+ centers in the SrCl 2 :Pr, K crystals. • Under X-ray excitation at 80–300 K only Pr 3+ 4f–4f and intrinsic emission is observed

Comparing the physical properties of Pr/Gd and Pr/Ce substitutions in Ru(Gd1.5Ce0.5)Sr2Cu2O10- δ

Science.gov (United States)

Khajehnezhad, A.; Nikseresht, N.; Hadipour, H.; Akhavan, M.

2008-06-01

We have compared the electrical and magnetic properties of Ru(Gd1.5- x Pr x )Ce0.5Sr2Cu2O10- δ (Pr/Gd samples) with x = 0.0, 0.01, 0.03, 0.033, 0.035, 0.04, 0.05, 0.06, 0.1 and RuGd1.5(Ce0.5- x Pr x ) Sr2 Cu2O10- δ (Pr/Ce samples) with x = 0.0, 0.01, 0.03, 0.05, 0.08, 0.1, 0.15, 0.2 prepared by the standard solid-state reaction technique. We obtained the XRD patterns for different samples with various x. The lattice parameters versus x for different substitutions have been obtained from Rietveld analysis. To determine how the magnetic and superconducting properties of these layered cuprate systems can be affected by Pr substitution, the resistivity, and magnetoresistivity, with H ext varying from 0.0 to 15 kOe, have been measured at various temperatures. Superconducting transition temperature T c and magnetic transition T irr , have been obtained through resistivity and ac susceptibility measurements. The T c suppression due to Pr/Gd and Pr/Ce substitutions show competition between pair breaking by magnetic impurities, hole doping due to different valances of ions, difference in ionic radii, and oxygen stoichiometry. Pr/Gd substitution suppresses superconductivity more rapidly than for Pr/Ce, showing that the effect of hole doping and magnetic impurity pair breaking is stronger than the difference in ionic radii. In Pr/Gd substitution, the small difference between the ionic radii of Pr3+,4+ and Gd3+, and absorption of more oxygen due to the higher valence of Pr with respect to Gd, decreases the mean Ru-Ru distance, and as a result, the magnetic exchange interaction becomes stronger with the increase of x. However, Pr/Ce substitution has the opposite effect. The magnetic parameters such as H c , obtained through magnetization measurements versus applied magnetic field isotherm at 77 K and room temperatures, become stronger with x in Pr/Gd and weaker with x in Pr/Ce substitution.

Early Delivery of Misfolded PrP from ER to Lysosomes by Autophagy

Science.gov (United States)

Cortes, Constanza J.; Qin, Kefeng; Norstrom, Eric M.; Green, William N.; Bindokas, Vytautas P.; Mastrianni, James A.

2013-01-01

Prion diseases are linked to the accumulation of a misfolded isoform (PrPSc) of prion protein (PrP). Evidence suggests that lysosomes are degradation endpoints and sites of the accumulation of PrPSc. We questioned whether lysosomes participate in the early quality control of newly generated misfolded PrP. We found PrP carrying the disease-associated T182A mutation (Mut-PrP) was delivered to lysosomes in a Golgi-independent manner. Time-lapse live cell imaging revealed early formation and uptake of GFP-tagged Mut-PrP aggregates into LysoTracker labeled vesicles. Compared with Wt-PrP, Mut-PrP expression was associated with an elevation in several markers of the autophagy-lysosomal pathway, and it extensively colocalized with the autophagosome-specific marker, LC3B. In autophagy deficient (ATG5−/−) mouse embryonic fibroblasts, or in normal cells treated with the autophagy-inhibitor 3-MA, Mut-PrP colocalization with lysosomes was reduced to a similar extent. Additionally, 3-MA selectively impaired the degradation of insoluble Mut-PrP, resulting in an increase in protease-resistant PrP, whereas the induction of autophagy by rapamycin reduced it. These findings suggest that autophagy might function as a quality control mechanism to limit the accumulation of misfolded PrP that normally leads to the generation of PrPSc. PMID:24454378

On the subgroups of PR groups

International Nuclear Information System (INIS)

Lebedenko, V.M.

1979-01-01

The subgroups of PR-groups are being studied, i.e., the subgroups of connected and simply connected nonabelian Lie groups, their Lie algebras being defined by the commuting relations of the type [Hsub(i), Hsub(j)] = rsub(ij)Hsub(i) (i 1 of PR-group G there exists such complementary subgroup G 2 and that group G is expanded in semidirect product G = G 1 xG 2 [ru

Features of the advertising and PR in tourism

OpenAIRE

M. A. Zubarieva

2015-01-01

The article discusses the use of topical issues of important tools of social communication of applied tactical direction (advertising) and strategic (PR). The main types of advertising in tourism and types of PR ­ activities are characterized.The main difference between advertising and PR in the tourism sector is defined, the main attention is given to correct choice of optimal (most efficient) advertising channel (means). Specific nature, advertising issues as the main tool for the promotion...

On orbits and admissible subalgebras for the PR groups

International Nuclear Information System (INIS)

Lebedenko, V.M.

1977-01-01

The PR-groups (Lie groups with commutation relations of [Hsub(i),Hsub(0)] = rsub(ij)Hsub(i) (i< j)-type) are investigated within the Kirillov orbit method. Orbits for all the PR-groups are constructed in a general form. For some classes of PR-groups orbits and admissible subalgebras are obtained in an explicit form

Pressure dependence of crystal field splitting in Pr pnictides and chalcogenides

International Nuclear Information System (INIS)

Schirber, J.E.; Weaver, H.T.; Ginley, D.S.

1978-01-01

We have measured the pressure dependence of the Pr nuclear magnetic resonance shift in PrN, PrP, PrSb, PrAs, PrS and PrSe. The shifts in all the pnictides increase while in the chalcogenides the shifts decrease with pressure. The rare earth frequency shift is inversely proportional to the crystal field splitting in the context of the point charge model (PCM) so a decrease would be expected for all of these materials at a rate of 5/3 the volume compressibility. Our values for the pnictides tend to be considerably larger than the PCM value as well as the wrong sign. The chalcogenide values are much nearer in magnitude and are of the right sign for the PCM. Contrary to the report of Guertin et al. we see no anomaly in the pressure dependence of the susceptibility of PrS. The fact that PrN which is reported to be non-metallic also shows the wrong sign for the PCM presents difficulties for various conduction electron explanations for this unexpected behavior of the pnictides

Overview of the Robert Wood Johnson Foundation Nurse Faculty Scholars program.

Science.gov (United States)

Campbell, Jacquelyn; Ladden, Maryjoan D; McBride, Angela Barron; Cimino, Andrea; Kostas-Polston, Elizabeth; Deming, Katie

The Robert Wood Johnson Foundation Nurse Faculty Scholars program was created to address the nursing faculty shortage and thereby decrease the nursing shortage. The purpose of the study was to describe the program development, implementation, and ongoing outcome evaluation. Data on scholarly productivity, impact of research, research funding, and leadership positions were compiled, including an h-index (impact of publications) comparison with a comparison group of other interdisciplinary faculty at the same institutions of the 90 current and alumni scholars. There is evidence of the achievements of the individual scholars; however, the effect of the synergy of the multiple components of the program is difficult to capture in traditional evaluation strategies. The sense of possibility and responsibility (to the profession, to improving the health of all Americans, and to one's school of nursing and university) was a significant outcome of the program. Lessons learned from the program are important for the leadership development and retention of nursing faculty. Copyright © 2017 Elsevier Inc. All rights reserved.

75 FR 57846 - Airworthiness Directives; Robert E. Rust, Jr. Model DeHavilland DH.C1 Chipmunk 21, DH.C1 Chipmunk...

Science.gov (United States)

2010-09-23

... Aircraft Certification Office (ACO), 1701 Columbia Avenue, College Park, Georgia 30337; telephone: (404... Airworthiness Directives; Robert E. Rust, Jr. Model DeHavilland DH.C1 Chipmunk 21, DH.C1 Chipmunk 22, and DH.C1... the Docket Office (phone: 800-647-5527) is Document Management Facility, U.S. Department of...

Nomes próprios em Paulo Leminski

Directory of Open Access Journals (Sweden)

Olga Kempinska

2011-06-01

Full Text Available Este artigo propõe uma discussão sobre o uso dos nomes próprios na obra de Paulo Leminski. Com especial atenção debruça- se sobre a relação entre o nome próprio e o processo social de identificação e de classificação e sobre o potencial subversivo do humor associado ao uso poético do nome próprio por Leminski. Em conclusão insiste-se na ambiguidade envolvida na recepção do humor, subversivo e, ao mesmo tempo, comprometido devido a seu apelo à empatia do leitor.

Fracasos en prótesis parcial removible

OpenAIRE

Samsó Manzanedo, Jorge; Salsench Cabré, Juan

1986-01-01

Escribir sobre fracasos en prótesis parcial removible entraña ciertas dificultades, entre ellas el especificar qué es un fracaso, qué es un error y lo más difícil, qué es el éxito. Los que esto escriben han visto prótesis parciales removibles ver­daderamente mal realizadas, que han causado un gran daño en el sis­tema estomatognático del portador sin que él se diera cuenta y lo que aún es peor, creyendo que su prótesis satisfacía plenamente los requeri­mientos para poderla considerar un éxito....

An insight to the molecular interactions of the FDA approved HIV PR drugs against L38L↑N↑L PR mutant.

Science.gov (United States)

Sanusi, Zainab K; Govender, Thavendran; Maguire, Glenn E M; Maseko, Sibusiso B; Lin, Johnson; Kruger, Hendrik G; Honarparvar, Bahareh

2018-03-01

The aspartate protease of the human immune deficiency type-1 virus (HIV-1) has become a crucial antiviral target in which many useful antiretroviral inhibitors have been developed. However, it seems the emergence of new HIV-1 PR mutations enhances drug resistance, hence, the available FDA approved drugs show less activity towards the protease. A mutation and insertion designated L38L↑N↑L PR was recently reported from subtype of C-SA HIV-1. An integrated two-layered ONIOM (QM:MM) method was employed in this study to examine the binding affinities of the nine HIV PR inhibitors against this mutant. The computed binding free energies as well as experimental data revealed a reduced inhibitory activity towards the L38L↑N↑L PR in comparison with subtype C-SA HIV-1 PR. This observation suggests that the insertion and mutations significantly affect the binding affinities or characteristics of the HIV PIs and/or parent PR. The same trend for the computational binding free energies was observed for eight of the nine inhibitors with respect to the experimental binding free energies. The outcome of this study shows that ONIOM method can be used as a reliable computational approach to rationalize lead compounds against specific targets. The nature of the intermolecular interactions in terms of the host-guest hydrogen bond interactions is discussed using the atoms in molecules (AIM) analysis. Natural bond orbital analysis was also used to determine the extent of charge transfer between the QM region of the L38L↑N↑L PR enzyme and FDA approved drugs. AIM analysis showed that the interaction between the QM region of the L38L↑N↑L PR and FDA approved drugs are electrostatic dominant, the bond stability computed from the NBO analysis supports the results from the AIM application. Future studies will focus on the improvement of the computational model by considering explicit water molecules in the active pocket. We believe that this approach has the potential to

An insight to the molecular interactions of the FDA approved HIV PR drugs against L38L↑N↑L PR mutant

Science.gov (United States)

Sanusi, Zainab K.; Govender, Thavendran; Maguire, Glenn E. M.; Maseko, Sibusiso B.; Lin, Johnson; Kruger, Hendrik G.; Honarparvar, Bahareh

2018-03-01

The aspartate protease of the human immune deficiency type-1 virus (HIV-1) has become a crucial antiviral target in which many useful antiretroviral inhibitors have been developed. However, it seems the emergence of new HIV-1 PR mutations enhances drug resistance, hence, the available FDA approved drugs show less activity towards the protease. A mutation and insertion designated L38L↑N↑L PR was recently reported from subtype of C-SA HIV-1. An integrated two-layered ONIOM (QM:MM) method was employed in this study to examine the binding affinities of the nine HIV PR inhibitors against this mutant. The computed binding free energies as well as experimental data revealed a reduced inhibitory activity towards the L38L↑N↑L PR in comparison with subtype C-SA HIV-1 PR. This observation suggests that the insertion and mutations significantly affect the binding affinities or characteristics of the HIV PIs and/or parent PR. The same trend for the computational binding free energies was observed for eight of the nine inhibitors with respect to the experimental binding free energies. The outcome of this study shows that ONIOM method can be used as a reliable computational approach to rationalize lead compounds against specific targets. The nature of the intermolecular interactions in terms of the host-guest hydrogen bond interactions is discussed using the atoms in molecules (AIM) analysis. Natural bond orbital analysis was also used to determine the extent of charge transfer between the QM region of the L38L↑N↑L PR enzyme and FDA approved drugs. AIM analysis showed that the interaction between the QM region of the L38L↑N↑L PR and FDA approved drugs are electrostatic dominant, the bond stability computed from the NBO analysis supports the results from the AIM application. Future studies will focus on the improvement of the computational model by considering explicit water molecules in the active pocket. We believe that this approach has the potential to provide

ESO PR Highlights in 2000

Science.gov (United States)

2001-01-01

At the beginning of the new millennium, ESO and its staff are facing the future with confidence. The four 8.2-m Unit Telescopes of the Very Large Telescope (VLT) are in great shape and the VLT Interferometer (VLTI) will soon have "first fringes". The intercontinental ALMA project is progressing well and concepts for extremely large optical/infrared telescopes are being studied. They can also look back at a fruitful and rewarding past year. Perhaps the most important, single development has been the rapid transition of the Very Large Telescope (VLT). From being a "high-tech project under construction" it has now become a highly proficient, world-class astronomical observatory. This trend is clearly reflected in ESO's Press Releases , as more and more front-line scientific results emerge from rich data obtained at this very efficient facility. There were also exciting news from several of the instruments at La Silla. At the same time, the ESO community may soon grow, as steps towards membership are being taken by various European countries. Throughout 2000, a total of 54 PR communications were made, with a large number of Press Photos and Video Clips, cf. the 2000 PR Index. Some of the ESO PR highlights may be accessed directly via the clickable image on the present page. ESO PR Photo 01/01 is also available in a larger (non-clickable) version [ JPEG: 566 x 566 pix - 112k]. It may be reproduced, if credit is given to the European Southern Observatory.

33 CFR 161.20 - Position Report (PR).

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Position Report (PR). 161.20 Section 161.20 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... Report (PR). A vessel must report its name and position: (a) Upon point of entry into a VMRS area; (b) At...

Plant Reliability - an Integrated System for Management (PR-ISM)

International Nuclear Information System (INIS)

Aukeman, M.C.; Leininger, E.G.; Carr, P.

1984-01-01

The Toledo Edison Company, located in Toledo, Ohio, United States of America, recently implemented a comprehensive maintenance management information system for the Davis-Besse Nuclear Power Station. The system is called PR-ISM, meaning Plant Reliability - An Integrated System for Management. PR-ISM provides the tools needed by station management to effectively plan and control maintenance and other plant activities. The PR-ISM system as it exists today consists of four integrated computer applications: equipment data base maintenance, maintenance work order control, administrative activity tracking, and technical specification compliance. PR-ISM is designed as an integrated on-line system and incorporates strong human factors features. PR-ISM provides each responsible person information to do his job on a daily basis and to look ahead towards future events. It goes beyond 'after the fact' reporting. In this respect, PR-ISM is an 'interactive' control system which: captures work requirements and commitments as they are identified, provides accurate and up-to-date status immediately to those who need it, simplifies paperwork and reduces the associated time delays, provides the information base for work management and reliability analysis, and improves productivity by replacing clerical tasks and consolidating maintenance activities. The functional and technical features of PR-ISM, the experience of Toledo Edison during the first year of operation, and the factors which led to the success of the development project are highlighted. (author)

PrP0\\0 mice show behavioral abnormalities that suggest PrPC has a role in maintaining the cytoskeleton.

Science.gov (United States)

Background/Introduction. PrPC is highly conserved among mammals, but its natural function is unclear. Prnp ablated mice (PrP0/0) appear to develop normally and are able to reproduce. These observations seem to indicate that the gene is not essential for viability, in spite of it being highly conse...

78 FR 40958 - Amendment of Restricted Areas R-2504A & R-2504B; Camp Roberts, CA, and Restricted Area R-2530...

Science.gov (United States)

2013-07-09

...-0515; Airspace Docket No. 13-AWP-8] RIN 2120-AA66 Amendment of Restricted Areas R-2504A & R-2504B; Camp Roberts, CA, and Restricted Area R-2530; Sierra Army Depot, CA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends the descriptions of restricted areas R...

Pena de muerte, peso de la ley, justicia simbólica y cultura jurídica escocesa en “El Weir de Hermiston” de Robert Louis Stevenson (Death Penalty, Force of the Law, Symbolic Justice and Scottish Legal Culture in Robert L. Stevenson's ‘Weir of Hermiston'

Directory of Open Access Journals (Sweden)

Iker Nabaskues

2017-12-01

Full Text Available La novela El Weir de Hermiston del autor escocés Robert Louis Stevenson es una valiosa fuente para el análisis del campo del Derecho y Literatura (Law and Literature. En la obra del autor escocés se retratan personajes basados en importantes juristas de la historia de Escocia y se plasma una cultura jurídica con fuertes influencias de la Escuela de la Ilustración Escocesa, proyectando sobre la novela un sentido de la justicia particular, ambiguo y sutil característicos tanto de Escocia como del genial escritor y moralista.Robert Louis Stevenson´s novel Weir of Hermiston is an interesting source for the analysis from the Law and Literature approach. Stevenson shows characters based on important jurists in the Scottish history and a legal culture rooted in the Scottish enlightenment tradition, projecting on the novel a particular, ambiguous and subtle sense of justice, characteristic of Scotland and the great writer and moralist.DOWNLOAD THIS PAPER FROM SSRN: http://ssrn.com/abstract=3067289

PrEP implementation in the Asia-Pacific region: opportunities, implementation and barriers

Science.gov (United States)

Zablotska, Iryna; Grulich, Andrew E; Phanuphak, Nittaya; Anand, Tarandeep; Janyam, Surang; Poonkasetwattana, Midnight; Baggaley, Rachel; van Griensven, Frits; Lo, Ying-Ru

2016-01-01

Introduction HIV epidemics in the Asia-Pacific region are concentrated among men who have sex with men (MSM) and other key populations. Pre-exposure prophylaxis (PrEP) is an effective HIV prevention intervention and could be a potential game changer in the region. We discuss the progress towards PrEP implementation in the Asia-Pacific region, including opportunities and barriers. Discussion Awareness about PrEP in the Asia-Pacific is still low and so are its levels of use. A high proportion of MSM who are aware of PrEP are willing to use it. Key PrEP implementation barriers include poor knowledge about PrEP, limited access to PrEP, weak or non-existent HIV prevention programmes for MSM and other key populations, high cost of PrEP, stigma and discrimination against key populations and restrictive laws in some countries. Only several clinical trials, demonstration projects and a few larger-scale implementation studies have been implemented so far in Thailand and Australia. However, novel approaches to PrEP implementation have emerged: researcher-, facility- and community-led models of care, with PrEP services for fee and for free. The WHO consolidated guidelines on HIV testing, treatment and prevention call for an expanded access to PrEP worldwide and have provided guidance on PrEP implementation in the region. Some countries like Australia have released national PrEP guidelines. There are growing community leadership and consultation processes to initiate PrEP implementation in Asia and the Pacific. Conclusions Countries of the Asia-Pacific region will benefit from adding PrEP to their HIV prevention packages, but for many this is a critical step that requires resourcing. Having an impact on the HIV epidemic requires investment. The next years should see the region transitioning from limited PrEP implementation projects to growing access to PrEP and expansion of HIV prevention programmes. PMID:27760688

Understanding Robert Lucas (1967-1981: his influence and influences

Directory of Open Access Journals (Sweden)

Alexandre F.S. Andrada

2017-05-01

Full Text Available This paper analyzes Robert Lucas's contribution to economic theory between 1967 (year of his first solo publication and 1981 (the year before the emergence of Real Business Cycle approach, and it has two parts. The first one, using citation data from three different sources, we try to answer two questions: (i What are Lucas's most influential papers currently? (ii How has this influence changed through time? We show, for instance, that according to two of those three sources, Lucas's most influential paper today is not from his business cycle research agenda, which gave him his Nobel Prize in 1995. Moreover, it is clear the loss of influence of Lucas's macroeconomic theory since the early 1980s. In the second part, by cataloging all the works that Lucas had used as bibliographical references in his papers and separating them in two categories (positive and negative, we try to understand who exerted influence on him. We show that the author that Lucas most cited in a positive context were John Muth, Milton Friedman and Edmund Phelps. The authors more often cited in a negative context were John M. Keynes and A. W. Phillips. We discuss the reasons behind this data.

Caruso St John y Robert Smithson: Interferencias

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Emilia Hernández Pezzi

2016-05-01

Full Text Available Resumen Los discursos cruzados son el soporte común del presente número de Cuadernos. El cruce que planteamos tiene como protagonistas al artista Robert Smithson y a los arquitectos Adam Caruso y Peter St John. Estos últimos hacen mención del trabajo del artista norteamericano para explicar su proyecto de remodelación de Stortorget, la plaza de la catedral en el centro de Kalmar, Suecia. A partir de aquí, comenzamos una exploración del trabajo y las preocupaciones de ambos que nos permite dibujar convergencias y sintonías procesuales por encima de las diferencias temáticas, ideológicas y estilísticas. Al disponer en paralelo la obra de Smithson y Caruso St John descubrimos vibraciones y resonancias que muestran una interacción productiva de sus preocupaciones. La materia se convierte en sus propuestas en un objeto activo y sensible, un depósito energético con el que operar. El traslado de piedras en Stortorget convoca la memoria de la ciudad del mismo modo que el basalto y la sal del Spiral Jetty, erosionados por el tiempo, nos hablan de procesos abiertos. El tiempo y la memoria pasan a ser soportes estratégicos con los que construyen sus miradas. Los objetos se disuelven en las relaciones que establecen con su entorno produciendo equilibrios frágiles e instantáneos. De esta manera el artículo pretende generar un vórtice de reflexión, una espiral en cuyo recorrido se manifiesten las tensiones parciales del cruce propuesto, sus fijezas momentáneas.

Cytosolically expressed PrP GPI-signal peptide interacts with mitochondria.

Science.gov (United States)

Guizzunti, Gianni; Zurzolo, Chiara

2015-01-01

We previously reported that PrP GPI-anchor signal peptide (GPI-SP) is specifically degraded by the proteasome. Additionally, we showed that the point mutation P238S, responsible for a genetic form of prion diseases, while not affecting the GPI-anchoring process, results in the accumulation of PrP GPI-SP, suggesting the possibility that PrP GPI-anchor signal peptide could play a role in neurodegenerative prion diseases. We now show that PrP GPI-SP, when expressed as a cytosolic peptide, is able to localize to the mitochondria and to induce mitochondrial fragmentation and vacuolarization, followed by loss in mitochondrial membrane potential, ultimately resulting in apoptosis. Our results identify the GPI-SP of PrP as a novel candidate responsible for the impairment in mitochondrial function involved in the synaptic pathology observed in prion diseases, establishing a link between PrP GPI-SP accumulation and neuronal death.

Study into non-quasibinary sections of Pr2S3-Bi2S3-Pr2O3 triple system (Bi2S3)0. 45(Pr2O3)0. 55 - (Bi2S3)0. 45(Pr2S3)0. 55 and (Bi2S3)0. 75 (Pr2S3)0. 25 - (Bi2S3)0. 75(Pr2O3)0. 25

OpenAIRE

НЕЙМАТОВА А.В.; МАМЕДОВ Ф.М.; БАХТИЯРЛЫ И.Б.

2016-01-01

Методами дифференциальнo-термическoго (ДТ), рентгенофазового (РФ), микроструктурного (МС) методов анализа исследованы неквазибинарные разрезы (Bi2S3)0.45(Pr2O3)0.55 (Bi2S3)0.45(Pr2S3)0.55 и (Bi2S3)0.75 (Pr2S3)0.25 (Bi2S3)0.75(Pr2O3)0.25 тройной системы Pr2S3-Bi2S3-Pr2O3 построена диаграмма состояния, определены координанты нони моновариантныхравновесий....

Chromatid repulsion associated with Roberts/SC phocomelia syndrome is reduced in malignant cells and not expressed in interspecies somatic-cell hybrids.

Science.gov (United States)

Krassikoff, N E; Cowan, J M; Parry, D M; Francke, U

1986-01-01

Different cell types from a female patient with Roberts/SC phocomelia syndrome were evaluated quantitatively for the presence of repulsion of heterochromatin and satellite regions of mitotic chromosomes. Whereas EBV-transformed lymphoblasts from an established cell line revealed these phenomena at frequencies equal to those in PHA-stimulated lymphocytes and cultured skin fibroblasts, aneuploid cells from a metastatic melanoma displayed them at 50% lower frequency. Cocultivation of the patient's fibroblasts with either an immortal Chinese hamster cell line or with a human male fibroblast strain carrying a t(4;6)(p14;q21) translocation showed that the phenomenon was not corrected or induced by a diffusible factor or by cell-to-cell contact. In each experiment, only the patient's metaphase spreads revealed chromatid repulsion. In fusion hybrids between the patient's fibroblasts and an established Chinese hamster cell line, the human chromosomes behaved perfectly normally, suggesting that the gene product which is missing or mutant in Roberts/SC phocomelia syndrome is supplied by the Chinese hamster genome. Images Fig. 1 Fig. 2 Fig. 3 PMID:3788975

Health aspects of Arctic exploration – Alaska's medical history based on the research files of Dr. Robert Fortuine

Directory of Open Access Journals (Sweden)

Kathleen Murray

2013-08-01

Full Text Available Background . Robert Fortuine provided basic medical care to Alaska Native people, chronicled the Health Aspects of Arctic Exploration and through a number of influential publications, was the first to thoroughly document and analyse Alaska's Medical History. This overview of his published work will provide the reader with a detailed overview, so that they can begin to explore Dr. Fortuine's many published works in more detail. Objective . This review will explore Alaska's Medical History and the Health Aspects of Arctic Exploration through the research files and the 10 most significant publications of Dr. Robert Fortuine. Design . Review of Dr. Fortuine's major works and the master bibliography has over 3,000 references and 81 subjects. The master bibliography is a merger of 55 separate bibliographies, which provides a wealth of bibliographic information. This paper will describe his 10 most significant publications, 2 of which began as a journal issue. Results . Dr. Fortuine was a prolific writer throughout his career, publishing 134 articles and books. He wrote papers and books on Alaska's medical history, tuberculosis and health care delivery from Russian–America through the Public Health Service efforts in the territory and then the State of Alaska. The master bibliography has over 3,000 references and 81 subjects. This list has a significant number of entries for tuberculosis with almost one-third of the entries including this heading. Others dwell on the history of “pre-contact” health, the history of Alaska Native health care, the history of the Alaska Department of Health, especially the tuberculosis programme, the role of the US Public Health Service and traditional medicine. He completely reviewed every Governors’ and the US Surgeon General's reports in regard to Alaska content. This paper describes his 10 most significant publications. Conclusions . Robert Fortuine's published works offer a wealth of information and insight

Robert Lowell’s Culturally Coded Lexis

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Lidija Davidovska

2014-12-01

Full Text Available In this paper, I will examine how a vital ele­ment of Robert Lowell’s descriptive and narrative struc­tures, i.e., the lexis, promise to unfold the “layers” of the culture that served as context for Life Studies. This in­volves exploring both the denotations and connotations of his culturally encoded lexis, that is, the external mean­ings of certain words and phrases before they “en­ter” the poem and the internal meanings they acquire after entering the poem. This process of “verbal osmo­sis”, when words absorb meaning from these different contexts, is, what I believe, critic and linguist Winifred Nowottny describes as “give and take between those patterns” (Fowler, 2009: 31. My analysis will focus on the sociolinguistic patina accrued on certain units of Lowell’s poetic lexis, such as names of historical people, events and concepts belonging to American and Euro­pean spiritual cultures and traditions, as well as brand names from popular material culture of the first half of the twentieth century. The analysis will also dwell on the use of idioms, catch phrases and other verbal clichés which reflect the culture that generated them. They func­tion as verbal “ready-mades” that additionally rein­force Lowell’s well-known anecdotal, colloquial and infor­mal poetic language. The choice of these particular lexical items is significant as they reflect the categoriza­tion of the world and the experience of the poetic voice or the “language user” in broader linguistic terms. At the same time, the categorization of the experience reflects the ideational position, the worldview of the language user. In the context of his poetics of immanence and experi­ence, this culturally coded poetic diction is ana­lyzed as another authentic and documented presenta­tion of immanent narrator’s “lived experience”.

Application of the GIF PR and PP methodology to a commercial fast reactor system for a preliminary analysis of PR scenarios

International Nuclear Information System (INIS)

Rossi, Fabiana

2015-01-01

The Generation IV International Forum (GIF) Proliferation Resistance and Physical Protection (PR and PP) Working Group has developed a methodology for the PR and PP evaluation of the next generation Nuclear Energy Systems (NESs). Following the methodology proposed by the working group, applicable to assessing the proliferation resistance of an NES and its individual elements, the main objective of this work is to apply the methodology to show an example of how its results could be used by designers to improve the PR of the system. In this study, the reactor site of a hypothetical and commercial sodium‑cooled fast neutron nuclear reactor system (SFR) was used as the target NES for the application of the methodology. The design of this SFR is based on the layout of the Japanese Sodium Fast Reactor (JSFR) with a safeguards design based on the safeguards approach of the Japanese prototype fast breeder reactor Monju. The methodology is applied to all the PR scenarios described in the methodology: diversion, misuse and breakout. The methodology was first applied to the SFR to check if this system meets the target of PR as described in the GIF goal; secondly, a comparison between the SFR and a light water reactor (LWR) with an open fuel cycle was performed to evaluate if and how it would be possible to improve the PR and PP of the SFR. The LWR layout is based on the European Pressurized Water Reactor. The comparison was implemented according to the following example development target: achieving proliferation resistance to material diversion similar or superior to domestic and international advanced LWR. Three main actions were performed: implement the evaluation methodology based on its assumptions; characterize the PR and PP for the nuclear energy system applying the methodology to the SFR; and identify recommendations for system designers through comparing the SFR with the LWR.

RIZ Tumor and Breast Cancer: The PR Domain

National Research Council Canada - National Science Library

Aznar-Derunes, Celine

2005-01-01

.... RIZ is the founding member of the PR-domain family of zinc finger genes. Two protein products are produced from the RIZ gene which differ by the presence or the absence of the PR domain: RIZ1 and RIZ2...

Phase equilibria of the Al-Pr-Zr ternary system at 773 K

International Nuclear Information System (INIS)

She, Jia; Zhan, Yongzhong; Li, Chunliu; Du, Yong; Xu, Honghui; He, Yuehui

2010-01-01

The phase equilibria of the Al-Pr-Zr ternary system at 773 K have been investigated mainly by means of X-ray powder diffraction (XRD), scanning electron microscopy (SEM) and differential thermal analysis (DTA). The 14 binary compounds, i.e. AlZr 3 , AlZr 2 , Al 2 Zr 3 , Al 3 Zr 4 , AlZr, Al 3 Zr 2 , Al 2 Zr, Al 3 Zr, α-Al 11 Pr 3 , Al 3 Pr, Al 2 Pr, β-AlPr, AlPr 2 and β-AlPr 3 were confirmed. No binary compound was found in the Pr-Zr binary system. The result shows that the isothermal section of the Al-Pr-Zr ternary system at 773 K consists of 17 single-phase regions, 31 two-phase regions and 15 three-phase regions. All the intermediate compounds phases in this system have not a remarkable solid solution at 773 K. No ternary compound is found in this work.

The thermodynamic characteristics of vaporization in the NaI-PrI3 system

Science.gov (United States)

Motalov, V. B.; Kudin, L. S.; Markus, T.

2009-05-01

The vaporization of the NaI-PrI3 quasi-binary system was studied by high-temperature mass spectrometry over the whole concentration range. At 623-994 K, saturated vapor contained not only (NaI) n and (PrI3) n molecules ( n = 1, 2) and Na+(NaI) n ( n = 0-4) and I-(PrI3) n ( n = 1-2) ions but also mixed molecular and ionic associates recorded for the first time (NaPrI4, Na2PrI5, NaPrI{3/+}, Na2PrI{4/+}, Na3PrI{5/+}, Na4PrI{6/+}, NaPrI{5/-}, and NaPr2I{8/-}). The partial vapor pressures of molecules were calculated, and the equilibrium constants of the dissociation of neutral and charged associates were measured. The enthalpies of molecular and ion-molecular reactions were determined, and the enthalpies of formation of gaseous molecules and ions were obtained.

Quantitating PrP Polymorphisms Present in Prions from Heterozygous Scrapie-Infected Sheep.

Science.gov (United States)

Silva, Christopher J; Erickson-Beltran, Melissa L; Hui, Colleen; Badiola, Juan José; Nicholson, Eric M; Requena, Jesús R; Bolea, Rosa

2017-01-03

Scrapie is a prion (PrP Sc ) disease of sheep. The incubation period of sheep scrapie is strongly influenced by polymorphisms at positions 136, 154, and 171 of a sheep's normal cellular prion protein (PrP C ). Chymotrypsin was used to digest sheep recombinant PrP to identify a set of characteristic peptides [M 132 LGSXMSRPL 141 (X = A or V), Y 153 XENMY 158 (X,= H or R), and Y 166 RPVDXY 172 (X = H, K, Q, or R)] that could be used to detect and quantitate polymorphisms at positions 136, 154, and 171 of sheep PrP C or PrP Sc . These peptides were used to develop a multiple reaction monitoring method (MRM) to detect the amounts of a particular polymorphism in a sample of PrP Sc isolated from sheep heterozygous for their PrP C proteins. The limit of detection for these peptides was less than 50 attomole. Spinal cord tissue from heterozygous (ARQ/VRQ or ARH/ARQ) scrapie-infected Rasa Aragonesa sheep was analyzed using this MRM method. Both sets of heterozygotes show the presence of both polymorphisms in PrP Sc . This was true for samples containing both proteinase K (PK)-sensitive and PK-resistant PrP Sc and samples containing only the PK-resistant PrP Sc . These results show that heterozygous animals contain PrP Sc that is composed of significant amounts of both PrP polymorphisms.

Robert J. Shiller: Nobel prize for 2013: Capital market efficiency

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Pantelić Svetlana

2015-01-01

Full Text Available In 2013 the Nobel Prize in Economic Sciences was awarded to the American economists, Eugene Fama, Lars Peter Hansen and Robert Shiller. The monetarists, Fama and Hansen, from the University of Chicago, and the Neo- Keynesian, Shiller, from the Yale University, according to the Swedish Royal Academy, won this prestigious prize for their research providing mathematical and economic models to determine (irregularities in the stock value trends at the stock exchanges. With his colleagues, in the 1960s Fama established that, in the short term, it is extremely difficult to forecast stock prices, given that new information gets embedded in the prices rather quickly. Shiller, however, determined that, although it is almost impossible to predict the stock prices for a period of few days, this is not true for a period of several years. He discovered that the stock prices fluctuate much more substantially than corporation dividents, and that the relationship between prices and dividends tends to decline when high, and to grow when low. This pattern does not apply only to stocks, but also to bonds and other forms of capital.

A phase III randomized controlled study on the efficacy and improved bowel function of prolonged-release (PR) oxycodone-naloxone (up to 160/80 mg daily) vs oxycodone PR.

Science.gov (United States)

Dupoiron, D; Stachowiak, A; Loewenstein, O; Ellery, A; Kremers, W; Bosse, B; Hopp, M

2017-10-01

Oxycodone/naloxone (OXN PR) is a prolonged-release formulation containing oxycodone and naloxone in a 2:1 ratio. This study aimed to evaluate the tolerability and efficacy of doses up to OXN160/80 mg PR compared with oxycodone prolonged-release formulation (OxyPR) in a randomised controlled trial. Two hundred and forty-three patients were randomised to treatment with OXN PR (n = 123) or OxyPR (n = 120) during the 5-week double-blind study. Measured were: opioid-induced constipation [bowel function index score (BFI)]; analgesic efficacy (NRS 0-10); daily laxative rescue medication use; rescue medication use, and the number of complete spontaneous bowel movements (CSBMs) per week. A subanalysis was conducted in cancer patients. Greater reductions in mean BFI scores were reported for the OXN PR group compared with OxyPR from Week 1 onwards; at Week 5 the mean change from baseline was -32.5 versus -14.2. Average 24-h pain scores were low and remained stable in the range 3-4 in both treatment groups. Analgesic rescue medication use was similar between the groups. Patients receiving OXN PR used significantly lower mean daily doses of laxative rescue medication than those receiving OxyPR (P = 0.006). The number of CSBM in the OXN PR group approximately doubled compared with a 25% decrease in the OxyPR group. Comparable results to the total study population were reported in the cancer patient subgroup. OXN PR in daily doses of up to 160/80 mg significantly improves bowel function compared with equivalent doses of OxyPR while still providing comparable analgesic efficacy. Effective analgesia can be achieved using oxycodone/naloxone PR up to 160/80 mg daily without compromising bowel function. A similar outcome was reported in cancer and non-cancer patients. © 2017 The Authors. European Journal of Pain published by John Wiley & Sons Ltd on behalf of European Pain Federation - EFIC®.

Deletion of Pr130 Interrupts Cardiac Development in Zebrafish

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Jie Yang

2016-11-01

Full Text Available Protein phosphatase 2 regulatory subunit B, alpha (PPP2R3A, a regulatory subunit of protein phosphatase 2A (PP2A, is a major serine/threonine phosphatase that regulates crucial function in development and growth. Previous research has implied that PPP2R3A was involved in heart failure, and PR130, the largest transcription of PPP2R3A, functioning in the calcium release of sarcoplasmic reticulum (SR, plays an important role in the excitation-contraction (EC coupling. To obtain a better understanding of PR130 functions in myocardium and cardiac development, two pr130-deletion zebrafish lines were generated using clustered regularly interspaced short palindromic repeats (CRISPR/CRISPR-associated proteins (Cas system. Pr130-knockout zebrafish exhibited cardiac looping defects and decreased cardiac function (decreased fractional area and fractional shortening. Hematoxylin and eosin (H&E staining demonstrated reduced cardiomyocytes. Subsequent transmission electron microscopy revealed that the bright and dark bands were narrowed and blurred, the Z- and M-lines were fogged, and the gaps between longitudinal myocardial fibers were increased. Additionally, increased apoptosis was observed in cardiomyocyte in pr130-knockout zebrafish compared to wild-type (WT. Taken together, our results suggest that pr130 is required for normal myocardium formation and efficient cardiac contractile function.

Las prácticas en el contexto comunicativo

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Guillermo Orozco Gómez

2015-01-01

Full Text Available La comunicación debe ser entendida como proceso y producto de diversas prácticas sociales, cuyos componentes básicos son la sociabilidad, la ritualidad y la tecnicidad. Desde una perspectiva democrática, esas prácticas deben ser fortalecidas, especialmente en uno de sus aspectos esenciales: el diálogo y los "escenarios para ese diálogo". Actualmente el desafío radica en el fortalecimiento de las prácticas sociales -autónomas y democráticas- y especialmente de la comunicación, producto y componente de ellas.

Phase equilibria of the Al-Pr-Zr ternary system at 773 K

Energy Technology Data Exchange (ETDEWEB)

She, Jia [Laboratory of Nonferrous Metal Materials and New Processing Technology, Ministry of Education, Guangxi University, Nanning, Guangxi 530004 (China); Zhan, Yongzhong, E-mail: zyzmatres@yahoo.com.c [Laboratory of Nonferrous Metal Materials and New Processing Technology, Ministry of Education, Guangxi University, Nanning, Guangxi 530004 (China); Li, Chunliu [Laboratory of Nonferrous Metal Materials and New Processing Technology, Ministry of Education, Guangxi University, Nanning, Guangxi 530004 (China); Du, Yong; Xu, Honghui; He, Yuehui [State Key Laboratory of Powder Metallurgy, Central South University, Changsha, Hunan 410083 (China)

2010-07-30

The phase equilibria of the Al-Pr-Zr ternary system at 773 K have been investigated mainly by means of X-ray powder diffraction (XRD), scanning electron microscopy (SEM) and differential thermal analysis (DTA). The 14 binary compounds, i.e. AlZr{sub 3}, AlZr{sub 2}, Al{sub 2}Zr{sub 3}, Al{sub 3}Zr{sub 4}, AlZr, Al{sub 3}Zr{sub 2}, Al{sub 2}Zr, Al{sub 3}Zr, {alpha}-Al{sub 11}Pr{sub 3}, Al{sub 3}Pr, Al{sub 2}Pr, {beta}-AlPr, AlPr{sub 2} and {beta}-AlPr{sub 3} were confirmed. No binary compound was found in the Pr-Zr binary system. The result shows that the isothermal section of the Al-Pr-Zr ternary system at 773 K consists of 17 single-phase regions, 31 two-phase regions and 15 three-phase regions. All the intermediate compounds phases in this system have not a remarkable solid solution at 773 K. No ternary compound is found in this work.

Pr2Fe14B/α-Fe nanocomposites for thermal applications

International Nuclear Information System (INIS)

Silva, Suelanny Carvalho da

2012-01-01

In this work, Pr x Fe 94 - x B 6 (x = 6, 8, 10 and 12) nanostructured powders were prepared by a combination of hydrogenation, disproportionation, desorption and recombination (HDDR) process with high energy milling applied to the mixture of an as-cast alloy (Pr 14 Fe 80 B 6 ) and α-Fe. The produced nanoparticles showed magnetic properties comparable to those reported in hyperthermia studies. The optimal time to obtain the magnetic nanoparticles is 5 hours (at 900 rpm). It was verified that longer milling times cause an increase in carbon percentage on the particles. The carbon is derived from oleic acid added as a surfactant in the milling step. The nanocomposites exhibit coercive force ranging from 80 Oe (6.5 kAm -1 ) to 170 Oe (13.5 kAm -1 ) and magnetic moments in the range of 81 129 Am2kg -1 . From the X-ray diffraction analyses, only two phases were found in all samples: α-Fe and the magnetic phase Pr 2 Fe 14 B. Individual nanoparticles with diameter of about 20 nm were verified. The samples studied presented heating when exposed to an alternating magnetic field (f = 222 kHz e H max ∼3.7 kAm -1 ) comparable to reported in literature. Temperature variations (ΔT) of the powders were: 51 K for Pr 6 Fe 88 B 6 , 41 K for Pr 8 Fe 86 B 6 , 38 K for Pr 10 Fe 8 4 B 6 and T = 34 K for Pr 12 Fe 82 B 6 . The specific absorption rates (SARs) of the powders were 201 Wkg -1 for Pr 6 Fe 88 B 6 composition, 158 Wkg -1 on the composition Pr 8 Fe 86 B 6 , and 114 Wkg -1 for Pr 10 Fe 84 B 6 and Pr 12 Fe 82 B 6 compositions. (author)

Role of cell death in the propagation of PrP(Sc) in immune cells.

Science.gov (United States)

Takahashi, Kenichi; Inoshima, Yasuo; Ishiguro, Naotaka

2015-03-01

A number of studies have suggested that macrophages, dendritic cells, and follicular dendritic cells play an important role in the propagation of PrP(Sc). Both accumulation and proteolysis of PrP(Sc) have been demonstrated in peripheral macrophages. Macrophages may act as reservoirs for PrP(Sc) particles if the cells die during transient PrP(Sc) propagation. However, whether cell death plays a role in PrP(Sc) propagation in macrophages remains unclear. In this study, we investigated the possibility of propagation and transmission of PrP(Sc) between dead immune cells and living neural cells. We found that under specific conditions, transient PrP(Sc) propagation occurs in dead cells, indicating that interaction between PrP(C) and PrP(Sc) on plasma membrane lipid rafts might be important for PrP(Sc) propagation. Co-culturing of killed donor PrP(Sc)-infected macrophages with recipient N2a-3 neuroblastoma cells accelerated PrP(Sc) transmission. Our results suggest that cell death may play an important role in PrP(Sc) propagation, whereas transient PrP(Sc) propagation in macrophages has little effect on PrP(Sc) transmission.

OF SOCIAL NETWORKS AND LINGUISTIC INFLUENCE: THE LANGUAGE OF ROBERT LOWTH AND HIS CORRESPONDENTS

Directory of Open Access Journals (Sweden)

Ingrid Tieken-Boon van Ostade

2005-06-01

Full Text Available Analysing the unpublished correspondence of Robert Lowth, author of A Short Introduction to English Grammar (1762, this article attempts to find evidence of linguistic influence between people belonging to the same social network. Such evidence is used to try and determine where Lowth found the linguistic norm he presented in his grammar. Adding to the data presented by Nevalainen and Raumolin Bmnberg (2003 on the basis of their study of fourteen morphosyntactic items in the Corpus of Early English Correspondence, a detailed analysis is presented of eighteenth-century English. One of the results is an explanation for the presence in Lowth's grammar of the stricture against double negation at a time when double negation was no longer in current use.

Análisis Epistemológico del Modelo de Aprendizaje Acumulativo de Robert Gagne

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Anibal Meza

1993-12-01

Full Text Available Se reseñan aspectos fundamentales de la psicología del aprendizaje de Robert Gagné, destacando sus bases filosóficas (positivismo y pragmatismo y científicas ( conductismo y modelo de procesamiento de la información y luego se evalúan dichos aspectos desde una perspectiva epistemológica en términos de sus <

Genetic human prion disease modelled in PrP transgenic Drosophila.

Science.gov (United States)

Thackray, Alana M; Cardova, Alzbeta; Wolf, Hanna; Pradl, Lydia; Vorberg, Ina; Jackson, Walker S; Bujdoso, Raymond

2017-09-20

Inherited human prion diseases, such as fatal familial insomnia (FFI) and familial Creutzfeldt-Jakob disease (fCJD), are associated with autosomal dominant mutations in the human prion protein gene PRNP and accumulation of PrP Sc , an abnormal isomer of the normal host protein PrP C , in the brain of affected individuals. PrP Sc is the principal component of the transmissible neurotoxic prion agent. It is important to identify molecular pathways and cellular processes that regulate prion formation and prion-induced neurotoxicity. This will allow identification of possible therapeutic interventions for individuals with, or at risk from, genetic human prion disease. Increasingly, Drosophila has been used to model human neurodegenerative disease. An important unanswered question is whether genetic prion disease with concomitant spontaneous prion formation can be modelled in Drosophila We have used pUAST/PhiC31-mediated site-directed mutagenesis to generate Drosophila transgenic for murine or hamster PrP (prion protein) that carry single-codon mutations associated with genetic human prion disease. Mouse or hamster PrP harbouring an FFI (D178N) or fCJD (E200K) mutation showed mild Proteinase K resistance when expressed in Drosophila Adult Drosophila transgenic for FFI or fCJD variants of mouse or hamster PrP displayed a spontaneous decline in locomotor ability that increased in severity as the flies aged. Significantly, this mutant PrP-mediated neurotoxic fly phenotype was transferable to recipient Drosophila that expressed the wild-type form of the transgene. Collectively, our novel data are indicative of the spontaneous formation of a PrP-dependent neurotoxic phenotype in FFI- or CJD-PrP transgenic Drosophila and show that inherited human prion disease can be modelled in this invertebrate host. © 2017 The Author(s).

The Role of Shed PrPc in the Neuropathogenesis of HIV Infection.

Science.gov (United States)

Megra, Bezawit W; Eugenin, Eliseo A; Berman, Joan W

2017-07-01

HIV-1 enters the CNS soon after peripheral infection and causes chronic neuroinflammation and neuronal damage that leads to cognitive impairment in 40-70% of HIV-infected people. The nonpathogenic cellular isoform of the human prion protein (PrP c ) is an adhesion molecule constitutively expressed in the CNS. Previously, our laboratory showed that shed PrP c (sPrP c ) is increased in the cerebrospinal fluid of HIV-infected people with cognitive deficits as compared with infected people with no impairment. In this article, we demonstrate that CCL2 and TNF-α, inflammatory mediators that are elevated in the CNS of HIV-infected people, increase shedding of PrP c from human astrocytes by increasing the active form of the metalloprotease ADAM10. We show that the consequence of this shedding can be the production of inflammatory mediators, because treatment of astrocytes with rPrP c increased secretion of CCL2, CXCL-12, and IL-8. Supernatants from rPrP c -treated astrocytes containing factors produced in response to this treatment, but not rPrP c by itself, cause increased chemotaxis of both uninfected and HIV-infected human monocytes, suggesting a role for sPrP c in monocyte recruitment into the brain. Furthermore, we examined whether PrP c participates in glutamate uptake and found that rPrP c decreased uptake of this metabolite in astrocytes, which could lead to neurotoxicity and neuronal loss. Collectively, our data characterize mediators involved in PrP c shedding and the effect of this sPrP c on monocyte chemotaxis and glutamate uptake from astrocytes. We propose that shedding of PrP c could be a potential target for therapeutics to limit the cognitive impairment characteristic of neuroAIDS. Copyright © 2017 by The American Association of Immunologists, Inc.

Human radiation studies: Remembering the early years. Oral history of biophysicist Robert Edmund Rowland, Ph.D., January 27, 1995

International Nuclear Information System (INIS)

1995-06-01

This report provides a transcript of an oral interview with Dr. Robert Edmund Rowland by representatives of the US DOE Office of Human Radiation Research on January 27, 1995. Dr. Rowland was involved with the study of radium in the human body since 1950 and relates his knowledge of over 40 years of study of radium in the human body including dial painters, inmates of Elgin State Hospital, and other treated therapeutically with radium

PR-10 proteins as potential mediators of melatonin-cytokinin cross-talk in plants: crystallographic studies of LlPR-10.2B isoform from yellow lupine.

Science.gov (United States)

Sliwiak, Joanna; Sikorski, Michal; Jaskolski, Mariusz

2018-04-06

LlPR-10.2B, a Pathogenesis-related class 10 (PR-10) protein from yellow lupine (Lupinus luteus) was crystallized in complex with melatonin, an emerging important plant regulator and antioxidant. The structure reveals two molecules of melatonin bound in the internal cavity of the protein, plus a very well-defined electron density near the cavity entrance, corresponding to an unknown ligand molecule comprised of two flat rings, which is most likely a product of melatonin transformation. In a separate LlPR-10.2B co-crystallization experiment with an equimolar mixture of melatonin and trans-zeatin, which is a cytokinin phytohormone well recognized as a PR-10-binding partner, a quaternary 1 : 1 : 1 : 1 complex was formed, in which one of the melatonin-binding sites has been substituted with trans-zeatin, whereas the binding of melatonin at the second binding site and binding of the unknown ligand are undisturbed. This unusual complex, when compared with the previously described PR-10/trans-zeatin complexes and with the emerging structural information about melatonin binding by PR-10 proteins, provides intriguing insights into the role of PR-10 proteins in phytohormone regulation in plants, especially with the involvement of melatonin, and implicates the PR-10 proteins as low-affinity melatonin binders under the conditions of elevated melatonin concentration. Atomic coordinates and processed structure factors corresponding to the final models of the LlPR-10.2B/melatonin and LlPR-10.2B/melatonin + trans-zeatin complexes have been deposited with the Protein Data Bank (PDB) under the accession codes 5MXB and 5MXW. The corresponding raw X-ray diffraction images have been deposited in the RepOD Repository at the Interdisciplinary Centre for Mathematical and Computational Modelling (ICM) of the University of Warsaw, Poland, and are available for download with the following Digital Object Identifiers (DOI): https://doi.org/10.18150/repod.9923638 and https://doi.org/10

spareparts.exchange: Rahim and Robert, Stitched Together in Silence (Creative Intervention

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Monir Moniruzzaman

2016-12-01

Full Text Available Spare Parts (spareparts.exchange is an art installation created collaboratively by Heather Dewey-Hagborg, Jim Ruxton, Camille Turner, and Monir Moniruzzaman. Based on Monir Moniruzzaman’s ethnographic research on the illicit organ trade, Spare Parts explores the ethics of organ trafficking and the emergence of bodily inequality in times of transplant tinkering. In this installation, the viewer is confronted with life sized video projections of Rahim Sheikh, a Bangladeshi kidney seller and Robert Zurrer, a Canadian kidney transplant recipient/buyer, whose kidneys were commodified in the marketplace. The video projections are installed so that the individuals sit in silence facing each other.  Spare Parts highlights the intimacy of spare parts, the economy of the global marketplace, the perils of techno-medicine, and what is means to be human in the 21st century. The installation captures that the buying and selling of body parts is not just a market transaction, but rather represents the desperation, dis/connection, and inequality that exists in the trade.

238. Prótesis percutáneas: el fin de la prótesis mecánica

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C. Porras

2012-04-01

Dado el bajo riesgo que representa una primera reintervención, especialmente a edad relativamente joven, creemos recomendable expandir la edad en la que se implantan prótesis biológicas en posición aórtica y difícil de justificar la implantación de prótesis mecánicas en dicha posición, salvo en pacientes muy jóvenes en los que la reparación valvular o el procedimiento de Ross no sean posibles.

Energy transfer of the quantum-cutter couple Pr{sup 3+}–Mn{sup 2+} in CaF{sub 2}:Pr{sup 3+}, Mn{sup 2+} nanoparticles

Energy Technology Data Exchange (ETDEWEB)

Kuzmanoski, Ana [Karlsruhe Institute of Technology (KIT), Institute of Inorganic Chemistry, Engesserstraße 15, D-76131 Karlsruhe (Germany); Pankratov, Vladimir, E-mail: vpank@latnet.lv [Research Center of Molecular Materials, University of Oulu, PO Box 3000, 90014 Oulu (Finland); Feldmann, Claus, E-mail: claus.feldmann@kit.edu [Karlsruhe Institute of Technology (KIT), Institute of Inorganic Chemistry, Engesserstraße 15, D-76131 Karlsruhe (Germany)

2016-11-15

CaF{sub 2}:Pr (1 mol%), CaF{sub 2}:Mn (5 mol%) and CaF{sub 2}:Pr,Mn (1 mol%, 5 mol%) nanoparticles are prepared via a microwave-mediated synthesis in ionic liquids. The nanoparticles are highly crystalline and exhibit particle diameters <50 nm.In contrast to bulk-CaF{sub 2}:Pr,Mn,energy transfer between Pr{sup 3+}and Mn{sup 2+}under {sup 1}S{sub 0}→{sup 1}I{sub 6} relaxation on Pr{sup 3+} and {sup 4}G({sup 4}T{sub 1g})→{sup 6}S(A{sub 1g}) emission of Mn{sup 2+} is observed for the first time. Such energy transfer represents the essential first step of the quantum-cutting cascade via the Pr{sup 3+}–Mn{sup 2+} couple, which is most interesting as both expected photons – {sup 3}P{sub 0}→{sup 3}H{sub 4} emission of Pr{sup 3+}and {sup 4}G({sup 4}T{sub 1g})→{sup 6}S(A{sub 1g}) emission of Mn{sup 2+} – are emitted in the green spectral range. While bulk crystals were said not to show energy transfer due to prohibiting selection rules, vacuum ultraviolet (VUV) spectroscopy of CaF{sub 2}:Pr, Mn nanoparticles firstly proves efficient Pr{sup 3+}→Mn{sup 2+} energy transfer, which can be ascribed to the reduced site symmetry and considerable spin–orbit interaction in the nanocrystals.

Magnetic properties in the vortex state of Pr1-xNdxPt4Ge12 and PrPt3.88Fe0.12Ge12 superconductors

Science.gov (United States)

Chandra, L. S. Sharath; Chattopadhyay, M. K.

2018-03-01

We report the temperature and magnetic field dependence of magnetization of Pr1-xNdxPt4Ge12 (x = 0, 0.05 and 0.1) and PrPt3.88Fe0.12Ge12 below 10 K and up to 2 T magnetic field. When compared to the parent PrPt4Ge12, while the critical current density and flux pinning properties are enhanced in the Pr1-xNdxPt4Ge12 samples, they are considerably diminished in the PrPt3.88Fe0.12Ge12 sample. We argue that the observed changes are related to the way the substituting atoms at different crystallographic sites influence the superconductivity in these Germanide skutterudites.

PR, Lobbyism and Democracy

DEFF Research Database (Denmark)

Ørsten, Mark; Willig, Ida; Pedersen, Leif Hemming

2017-01-01

The growth of PR in Scandinavia is linked both to the mediatization of politics and to the decline of corporatism. Studies in Sweden and Norway suggest that one consequence of these changes is the increasing number of politicians who find new careers as lobbyists in the private sector. In this st......The growth of PR in Scandinavia is linked both to the mediatization of politics and to the decline of corporatism. Studies in Sweden and Norway suggest that one consequence of these changes is the increasing number of politicians who find new careers as lobbyists in the private sector....... Still, 89 percent of all the registered job positions fall outside of lobbyism. 11 percent of the job positions fall within the wider field associated with the emerging field of policy professionals (including lobbyism), while lobbyism on its own accounts for 2 percent of the job positions....

Beyond PrPres Type 1/Type 2 Dichotomy in Creutzfeldt-Jakob Disease

Science.gov (United States)

Simon, Stéphanie; Lugan, Séverine; Bilheude, Jean-Marc; Perret-Liaudet, Armand; Ironside, James W.; Haik, Stéphane; Basset-Leobon, Christelle; Lacroux, Caroline; Peoch', Katell; Streichenberger, Nathalie; Langeveld, Jan; Head, Mark W.; Grassi, Jacques; Hauw, Jean-Jacques; Schelcher, Francois; Delisle, Marie Bernadette; Andréoletti, Olivier

2008-01-01

Sporadic Creutzfeldt-Jakob disease (sCJD) cases are currently subclassified according to the methionine/valine polymorphism at codon 129 of the PRNP gene and the proteinase K (PK) digested abnormal prion protein (PrPres) identified on Western blotting (type 1 or type 2). These biochemically distinct PrPres types have been considered to represent potential distinct prion strains. However, since cases of CJD show co-occurrence of type 1 and type 2 PrPres in the brain, the basis of this classification system and its relationship to agent strain are under discussion. Different brain areas from 41 sCJD and 12 iatrogenic CJD (iCJD) cases were investigated, using Western blotting for PrPres and two other biochemical assays reflecting the behaviour of the disease-associated form of the prion protein (PrPSc) under variable PK digestion conditions. In 30% of cases, both type 1 and type 2 PrPres were identified. Despite this, the other two biochemical assays found that PrPSc from an individual patient demonstrated uniform biochemical properties. Moreover, in sCJD, four distinct biochemical PrPSc subgroups were identified that correlated with the current sCJD clinico-pathological classification. In iCJD, four similar biochemical clusters were observed, but these did not correlate to any particular PRNP 129 polymorphism or western blot PrPres pattern. The identification of four different PrPSc biochemical subgroups in sCJD and iCJD, irrespective of the PRNP polymorphism at codon 129 and the PrPres isoform provides an alternative biochemical definition of PrPSc diversity and new insight in the perception of Human TSE agents variability. PMID:18389084

Anomalous properties of PrBa2Cu3O7: a comment

International Nuclear Information System (INIS)

Sampathkumaran, E.V.

1992-01-01

Considerable attention has been paid in the literature to understand the suppression of superconductivity and the large Neel temperature of the Pr sub-lattice in PrBa 2 Cu 3 O 7 . Here we briefly recall the superconducting and magnetic anomalies noted earlier in other Pr based systems due to the partial delocalisation of the Pr-4f orbital to show that the gross anomalous features observed for PrBa 2 Cu 4 O 7 are not unique. (orig.)

Estudo de fatores pró-trombóticos e pró-inflamatórios na cardiomiopatia chagásica

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Leila Maria Magalhães Pessoa de Melo

2010-10-01

Full Text Available FUNDAMENTO: A relação entre atividade inflamatória e pró-trombótica na cardiomiopatia chagásica e em outras etiologias é obscura. OBJETIVO: Estudar o perfil de marcadores pró-trombóticos e pró-inflamatórios em pacientes com insuficiência cardíaca chagásica e compará-los com os de etiologia não chagásica. MÉTODOS: Coorte transversal. Critérios de inclusão: fração de ejeção do VE (FEVE um mês. Os pacientes foram divididos em dois grupos: grupo 1 (G1 - sorologias positivas para Chagas - e grupo 2 (G2 - sorologias negativas para Chagas. Fator pró-inflamatório: PCR ultrassensível. Fatores pró-trombóticos: fator trombina-antitrombina, fibrinogênio, antígeno do fator de von Willebrand, P-selectina plasmática e tromboelastograma. Amostra calculada para poder de 80%, assumindo-se diferença de 1/3 de desvio-padrão; p significativo se < 0,05. Análise estatística: teste exato de Fischer para variáveis categóricas; teste t de Student não pareado para variáveis contínuas paramétricas e teste de Mann-Whitney para variáveis contínuas não paramétricas. RESULTADOS: Entre janeiro e junho de 2008, foram incluídos 150 pacientes, 80 no G1 e 70 no G2. Ambos os grupos mantinham médias de PCR ultrassensível acima dos valores de referência, porém, sem diferença significativa (p=0,328. Os níveis de fibrinogênio foram maiores no G2 do que no G1 (p=0,015. Entre as variáveis do tromboelastograma, os parâmetros MA (p=0,0013, G (p=0,0012 e TG (p=0,0005 foram maiores no G2 em comparação ao G1. CONCLUSÃO: Não há indícios de maior status pró-trombótico entre chagásicos. A dosagem de fibrinogênio e dos parâmetros MA, G e TG do tromboelastograma apontam para status pró-trombótico entre não chagásicos. Ambos os grupos tinham atividade inflamatória exacerbada.

Something black in the American Psyche: formal innovation and Freudian imagery in the comics of Winsor McCay and Robert Crumb.

Science.gov (United States)

Shannon, Edward A

2010-01-01

Winsor McCay’s Little Nemo in Slumberland anticipates Robert Crumb’s work. McCay’s innocent dreamscapes seem antithetical to the sexually explicit work of anti-capitalist Crumb, but Nemo looks forward to Crumb in subject and form. Nemo’s presentation of class, gender, and race, and its pre-Freudian sensibility are ironic counterpoints to Crumb’s political, Freudian comix.

Incommensurate magnetic ordering of PrPdAl

Energy Technology Data Exchange (ETDEWEB)

Keller, L. [Paul Scherrer Inst. (PSI), Villigen (Switzerland); Doenni, A. [National Research Inst. for Metals, Tsukuba, Ibaraki (Japan). Tsukuba Lab.; Fauth, F. [Institut Max von Laue - Paul Langevin, 75 - Paris (France)

1997-09-01

The intermetallic rare earth compound PrPdAl with ZrNiAl-type structure was investigated by means of powder neutron diffraction. PrPdAl orders below T{sub N} {approx_equal}4.2 K with an incommensurate antiferromagnetic propagation vector k = [1/2,0,{tau}], {tau}=0.398. The best fit was obtained with a sinusoidal modulation of the magnetic moments along the c-axis. (author) 2 figs., 2 refs.

Low fraction of the 222K PrP variant in the protease-resistant moiety of PrPres in heterozygous scrapie positive goats

OpenAIRE

Mazza, Maria; Guglielmetti, Chiara; Ingravalle, Francesco; Brusadore, Sonia; Langeveld, Jan P. M.; Ekateriniadou, Loukia V.; Andréoletti, Olivier; Casalone, Cristina; Acutis, Pier Luigi

2017-01-01

The presence of lysine (K) at codon 222 has been associated with resistance to classical scrapie in goats, but few scrapie cases have been identified in 222Q/K animals. To investigate the contribution of the 222K variant to PrPres formation in natural and experimental Q/K scrapie cases, we applied an immunoblotting method based on the use of two different monoclonal antibodies, F99/97.6.1 and SAF84, chosen for their different affinities to 222K and 222Q PrP variants. Our finding that PrPres s...

Statement of Robert Bernero, Deputy Director, Office of Nuclear Material Safety and Safeguards, Nuclear Regulatory Commission: Accompanied by Robert Browning, Director, Division of High-Level Waste Management

International Nuclear Information System (INIS)

Anon.

1987-01-01

Mr. Chairman, members of the Committee, thank you for this opportunity to present the views of the Nuclear Regulatory Commission (NRC) on the Department of Energy's (DOE) program for disposal of civilian high-level wastes. I have with me Mr. Robert Browning, Director of NRC's Division of High-Level Waste Management. As you know, we are in the pre-licensing consultation phase of the repository program. DOE has the responsibility to conduct site characterization activities to acquire data necessary to evaluate the suitability of each candidate site for an application to the Commission for construction authorization. I would like to discuss some of our concerns about site characterization at the three sites recommended to an approved by the President for characterization as candidate sites. It will then discuss our comments on DOE's Draft Mission Plan Amendment dated January, 1987 and, more generally, our interaction with DOE. Finally, I would like to describe our quality assurance activities. I will be happy to respond to any questions from the Committee

Preparing for the Rollout of Pre-Exposure Prophylaxis (PrEP: A Vignette Survey to Identify Intended Sexual Behaviors among Women in Kenya and South Africa if Using PrEP.

Directory of Open Access Journals (Sweden)

Amy Corneli

Full Text Available Several clinical trials have demonstrated the efficacy of pre-exposure prophylaxis (PrEP in reducing HIV risk. One concern with introducing PrEP is whether users will engage in riskier sexual behaviors.We assessed the effect that PrEP may have on sexual risk behaviors by administering a survey to 799 women in Bondo, Kenya, and Pretoria, South Africa. Participants were asked about their sexual behavior intentions twice--once as if they were taking PrEP and once as if they were not taking PrEP--within four risk situations (vignettes. They responded using a 5-point ordinal scale. We used a series of linear mixed effects models with an unstructured residual covariance matrix to estimate the between- and within-subject differences in the mean likelihood of engaging in risky sexual behavior across the PrEP and non-PrEP contexts. We also calculated the total percentage of participants who reported a greater likelihood of engaging in risky sexual behavior if taking PrEP than if not taking PrEP, by vignette.We found statistically significant differences in the mean likelihood of engaging in risky sexual behavior with the between-subject comparison (-0.17, p < 0.01 and with the within-subject comparison (-0.31, p < 0.001. Depending on the vignette, 27% to 40% of participants reported a greater likelihood of engaging in risky sexual behavior if taking PrEP than if not taking PrEP.Our findings indicate that modest increases in risky sexual behavior could occur with PrEP. Although responses from the majority of participants suggest they would not be more likely to engage in risky sexual behavior if they took PrEP, a substantial proportion might. Programs rolling out PrEP should be prepared to assist similar women in making informed choices about reducing their risk of HIV and about their sexual health beyond HIV prevention.

Selective recognition of Pr3+ based on fluorescence enhancement sensor

International Nuclear Information System (INIS)

Ganjali, M.R.; Hosseini, M.; Ghafarloo, A.; Khoobi, M.; Faridbod, F.; Shafiee, A.; Norouzi, P.

2013-01-01

(E)-2-(1-(4-hydroxy-2-oxo-2H-chromen-3-yl)ethylidene) hydrazinecarbothioamide (L) has been used to detect trace amounts of praseodymium ion in acetonitrile–water solution (MeCN/H 2 O) by fluorescence spectroscopy. The fluorescent probe undergoes fluorescent emission intensity enhancement upon binding to Pr 3+ ions in MeCN/H 2 O (9/1:v/v) solution. The fluorescence enhancement of L is attributed to a 1:1 complex formation between L and Pr 3+ , which has been utilized as the basis for selective detection of Pr 3+ . The sensor can be applied to the quantification of praseodymium ion with a linear range of 1.6 × 10 −7 to 1.0 × 10 −5 M. The limit of detection was 8.3 × 10 −8 M. The sensor exhibits high selectivity toward praseodymium ions in comparison with common metal ions. The proposed fluorescent sensor was successfully used for determination of Pr 3+ in water samples. - Highlights: • A new fluorescent sensor is introduced as a selective probe for Pr 3+ detection. • Fluorescent intensity of the chemical probe enhances upon binding to Pr 3+ ion. • The sensor can be used for Pr 3+ determination in the range of 1.6 × 10 −7 –1.0 × 10 −5 M

The role of e-PR in foreign policy

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Tereshchuk Vitaliy Ivanovych

2015-10-01

Full Text Available The article discusses the role of the Internet as a global communication tool in the PR-support of the implementation of foreign policy. Special attention is paid to such innovative directions of electronic foreign PR as the creation of "virtual embassies" (on the example of the United States.

PR-teenuse hind tõuseb 20% / Eda-Liis Kann

Index Scriptorium Estoniae

Kann, Eda-Liis, 1979-

2004-01-01

Suhtekorraldusfirmad prognoosivad aasta teiseks pooleks PR-teenuste 20protsendilist hinnatõusu. Kommenteerivad Kersti Luha, Maren Pärn, Ingrid Eha, Maria Raudsepp, Heidi Pihlak ja Rein Meripõld. Lisa: Väikefirmale on PR-teenus kallis

Features of the advertising and PR in tourism

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M. A. Zubarieva

2015-05-01

Full Text Available The article discusses the use of topical issues of important tools of social communication of applied tactical direction (advertising and strategic (PR. The main types of advertising in tourism and types of PR ­ activities are characterized.The main difference between advertising and PR in the tourism sector is defined, the main attention is given to correct choice of optimal (most efficient advertising channel (means. Specific nature, advertising issues as the main tool for the promotion of tourist product on the network market are defined. The advantages and importance of the innovation of the media as the Internet are detailed. the most popular types of Internet advertising in the tourism sector, in particular ­ placing information in catalogs of Internet resources; registration site in search engines work; banners; mailings via email are considered. The rating position of tourist sites on the Internet (top 15 is shown. A number of approaches to the study and systematization of information of Internet advertising in tourism, the specificity and modern advanced technologies of Internet advertising in the tourism sector are identified. The conclusion about the fact that considered issues about advertising and PR in tourism only form an idea of the complexity and diversity of tourism as advertising via newspapers, radio, television and especially of Internet means. The possibilities of tourism advertising and PR on the Internet have no limits.

The Robert Wood Johnson Foundation Nurse Faculty Scholars Program: An opportunity for junior nurse faculty

Science.gov (United States)

Coffman, Maren J.; Goodman, Janice H.; Thomas, Tami L.; Roberson, Donna

2014-01-01

The Robert Wood Johnson Foundation Nurse Faculty Scholars program provides promising junior faculty extramural funding, expert mentoring, and the training needed to be successful in the academic role. The Nurse Faculty Scholars program, which admitted its first cohort in 2008, is designed to address the nursing faculty shortage by enhancing leadership, educational, and research skills in junior nursing faculty. This article provides an overview of the program, its purpose, and its eligibility requirements. The authors give strategies for selecting mentors, developing the written application, and preparing for an oral interview. Finally, the authors provide an analysis of funded institutions, research design and methods from current and recently funded projects, and rank and positions held by nursing mentors. PMID:22818282

Relato de atividades práticas vivenciadas

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Marlise Rieger

2011-12-01

Full Text Available O presente artigo tem por principal objetivo a descrição e análise crítica das atividades práticas vivenciadas no Centro Municipal de Educação Infantil, localizada na cidade de Sinop-MT. O referido estágio Curricular Supervisionado foi realizado durante o sexto semestre do curso de Licenciatura Plena em Pedagogia. O qual é necessário para uma formação profissional a fim de adequar essa formação às expectativas do mercado de trabalho onde o licenciado irá atuar. O estágio de atividades práticas da oportunidade de aliar e fortalecer a teoria com a prática. A metodologia utilizada nas atividades práticas com as crianças foi de socializar e estimular a criatividade e a oralidade. Nas crianças, com a faixa etária de 4 e 5 anos, as mudanças ocorrem muito rápido e se processam aos saltos contínuos de organização, interagindo de diferentes maneiras no ambiente físico e social que o cerca numa instituição, diferente das que vive com suas famílias. O resultado obtido nesse estágio foi de suma importância para a compreensão, que cabe ao professor trabalhar com conteúdos diversos, básicos essenciais ate os conhecimentos específicos das diversas áreas do conhecimento. Palavras-chave: educação infantil; estágio curricular supervisionado; atividades práticas; crianças.

Faurisson, « falsificateur de la jurisprudence » ? Faurisson, “Falsifier of the Case Law”?

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Thomas Hochmann

2011-10-01

Full Text Available Pendant vingt-cinq ans, le négationniste Robert Faurisson s’est prévalu de la maladroite motivation d’un arrêt rendu par la cour d’appel de Paris en 1983. Il revendiquait à tort cet arrêt comme une consécration du sérieux de ses thèses, et poursuivait en l’invoquant ceux qui le décrivaient comme un faussaire de l’histoire. De la sorte, il a permis à la jurisprudence ultérieure de remédier à l’ambiguïté de cet arrêt. La présente étude retrace l’histoire de la démonstration progressive de l’inadéquation de l’interprétation faurissonienne de l’arrêt, qui culmina en 2007 dans le jugement déboutant Faurisson de sa plainte en diffamation contre Robert Badinter.During twenty-five years, Holocaust denier Robert Faurisson boasted of a 1983 decision by the Court of Appeal of Paris that, he alleged, paid tribute to his work and described it as scientific. This erroneous interpretation of the decision led him to invoke it while suing the numerous individuals who described him as a falsifier of history. This gave courts the opportunity to correct the clumsy grounds put forward in the 1983 decision and to expose the falsity of Faurisson’s reading of it. This process reached its climax in the libel judgment in favour of former lawyer and Minister of Justice Robert Badinter. This article recounts this story.

The thermodynamics of Pr55Gag-RNA interaction regulate the assembly of HIV.

Directory of Open Access Journals (Sweden)

Hanumant S Tanwar

2017-02-01

Full Text Available The interactions that occur during HIV Pr55Gag oligomerization and genomic RNA packaging are essential elements that facilitate HIV assembly. However, mechanistic details of these interactions are not clearly defined. Here, we overcome previous limitations in producing large quantities of full-length recombinant Pr55Gag that is required for isothermal titration calorimetry (ITC studies, and we have revealed the thermodynamic properties of HIV assembly for the first time. Thermodynamic analysis showed that the binding between RNA and HIV Pr55Gag is an energetically favourable reaction (ΔG<0 that is further enhanced by the oligomerization of Pr55Gag. The change in enthalpy (ΔH widens sequentially from: (1 Pr55Gag-Psi RNA binding during HIV genome selection; to (2 Pr55Gag-Guanosine Uridine (GU-containing RNA binding in cytoplasm/plasma membrane; and then to (3 Pr55Gag-Adenosine(A-containing RNA binding in immature HIV. These data imply the stepwise increments of heat being released during HIV biogenesis may help to facilitate the process of viral assembly. By mimicking the interactions between A-containing RNA and oligomeric Pr55Gag in immature HIV, it was noted that a p6 domain truncated Pr50Gag Δp6 is less efficient than full-length Pr55Gag in this thermodynamic process. These data suggest a potential unknown role of p6 in Pr55Gag-Pr55Gag oligomerization and/or Pr55Gag-RNA interaction during HIV assembly. Our data provide direct evidence on how nucleic acid sequences and the oligomeric state of Pr55Gag regulate HIV assembly.

Oxidation of Helix-3 methionines precedes the formation of PK resistant PrP.

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Tamar Canello

2010-07-01

Full Text Available While elucidating the peculiar epitope of the alpha-PrP mAb IPC2, we found that PrPSc exhibits the sulfoxidation of residue M213 as a covalent signature. Subsequent computational analysis predicted that the presence of sulfoxide groups at both Met residues 206 and 213 destabilize the alpha-fold, suggesting oxidation may facilitate the conversion of PrPC into PrPSc. To further study the effect of oxidation on prion formation, we generated pAbs to linear PrP peptides encompassing the Helix-3 region, as opposed to the non-linear complexed epitope of IPC2. We now show that pAbs, whose epitopes comprise Met residues, readily detected PrPC, but could not recognize most PrPSc bands unless they were vigorously reduced. Next, we showed that the alpha-Met pAbs did not recognize newly formed PrPSc, as is the case for the PK resistant PrP present in lines of prion infected cells. In addition, these reagents did not detect intermediate forms such as PK sensitive and partially aggregated PrPs present in infected brains. Finally, we show that PrP molecules harboring the pathogenic mutation E200K, which is linked to the most common form of familial CJD, may be spontaneously oxidized. We conclude that the oxidation of methionine residues in Helix-3 represents an early and important event in the conversion of PrPC to PrPSc. We believe that further investigation into the mechanism and role of PrP oxidation will be central in finally elucidating the mechanism by which a normal cell protein converts into a pathogenic entity that causes fatal brain degeneration.

Mechanoluminescence and photoluminescence of Pr3+ activated KMgF3 phosphor

International Nuclear Information System (INIS)

Dhoble, S.J.; Kher, R.S.; Furetta, C.

2003-01-01

A Czochralski method for the preparation of crystalline KMgF 3 : Pr phosphors are reported. Photoluminescence (PL) and mechanoluminescence (ML) characteristics are studied. Photoluminescence of Pr 3+ activated KMgF 3 shows the strong emission of Pr 3+ ions were observed at 498 and 650 nm by excitation of 213 mn. ML of KMgF 3 : Pr 3+ shows two peaks, which have been observed in ML intensity versus time curve. The ML peak shows the recombination of electrons with free radical (anion radical produced by γ-irradiation) released from two type traps during the mechanical pressure applied on KMgF 3 : Pr 3+ phosphor. It has a supra linear ML response with γ-ray exposure and a negligible fading. These properties of phosphor should be suitable in dosimetry of ionization relation using ML technique. Therefore the KMgF 3 : Pr 3+ phosphor proposed for ML dosimetry of ionization radiations. (Author)

Genetic and biochemical studies of the lipid-containing bacteriophage PR4

International Nuclear Information System (INIS)

Vanden Boom, T.J.

1989-01-01

Bacteriophage PR4 is a lipid-containing bacterial virus able to infect Escherichia coli and Salmonella typhimurium. The icosahedral virion consists of an external protein capsid layer which surrounds a membrane vesicle enclosed ds DNA genome. The author has analyzed the time course of phage PR4 protein synthesis and have identified at least 34 proteins present in phage infected cells not detected in uninfected control cultures. In addition, he has isolated a more extensive set of conditional-lethal nonsense mutants of this virus. This collection of mutants permitted the identification of seven additional phage PR4 gene products, including the terminal genome protein and an accessory lytic factor. The present collection of phage PR4 mutants has been assigned to 19 distinct genetic groups on the basis of genetic complementation tests and sodium dodecyl sulfate polyacrylamide gel electrophoresis analysis of the proteins produced in mutant-infected UV-irradiated cells. A restriction endonuclease map of the phage PR4 genome was constructed which includes 59 sites for ten restriction endonucleases. In addition, he has constructed a collection of recombinant plasmids containing subgenomic DNA fragments of bacteriophage PR4. He has used this collection of plasmids to generate a physical-genetic map of the PR4 genome. The physical-genetic map localizes mutations in 13 phage PR4 genetic groups on the viral DNA molecule. To investigate the role of phosphatidylglycerol (PG) in phage assembly and infectivity, he propagated PR4 on an E. coli mutant defective in PG synthesis. The PG content of phage PR4 grown on the mutant host accounted for 0.4% of the total viral phospholipids, representing a 90-fold decrease in PG relative to the PG content of phage grown on a wild type host

Elaboration and characterization of unreported (Pr,Nd)5Ni19 hydrides

International Nuclear Information System (INIS)

Lemort, Lucille; Latroche, Michel; Knosp, Bernard; Bernard, Patrick

2011-01-01

Research highlights: → Two new compounds Pr 5 Ni 19 and Nd 5 Ni 19 have been synthesized and their crystallographic structures have been determined. → Two polymorphic types are reported to coexist for the same composition, one rhombohedral and one hexagonal. → The hydrogen sorption properties of these two novel compounds have been measured and they exhibit capacities of 1.33%(wt) for Pr 5 Ni 19 and 1.17%(wt) for Nd 5 Ni 19 under 10 MPa. - Abstract: In this study two new compounds have been synthesized: Pr 5 Ni 19 and Nd 5 Ni 19 . The crystallographic structures as well as the thermodynamic properties of the hydrogen absorbing compounds Pr 5 Ni 19 and Nd 5 Ni 19 have been determined. Both compounds exist under two polymorphic types that can be described as the stacking along the c axis of two different subunits [(Pr,Nd) 2 Ni 4 ] and [(Pr,Nd)Ni 5 ]: the hexagonal (2H) Pr 5 Co 19 -type structure (space group P6 3 /mmc) and the rhombohedral (3R) Ce 5 Co 19 -type structure (space group R-3m). The two compounds are able to form hydrides at room temperature, in the pressure range of 0-10 MPa. They show desorption pressure plateaux around 0.8 MPa for Pr 5 Ni 19 and 1 MPa for Nd 5 Ni 19 and exhibit capacities under 10 MPa of 1.33 wt% for Pr 5 Ni 19 and 1.17 wt% for Nd 5 Ni 19 at the first cycle.

Phase relations in the SiC-Al2O3-Pr2O3 system

International Nuclear Information System (INIS)

Pan, W.; Wu, L.; Jiang, Y.; Huang, Z.

2016-01-01

Phase relations in the Si-Al-Pr-O-C system, including the SiC-Al 2 O 3 -Pr 2 O 3 , the Al 2 O 3 -Pr 2 O 3 -SiO 2 and the SiC-Al 2 O 3 -Pr 2 O 3 -SiO 2 subsystems, were determined by means of XRD phase analysis of solid-state-reacted samples fabricated by using SiC, Al 2 O 3 , Pr 2 O 3 and SiO 2 powders as the starting materials. Subsolidus phase diagrams of the systems were presented. Two Pr-aluminates, namely PrAlO 3 (PrAP) and PrAl 11 O 18 (β(Pr) β-Al 2 O 3 type) were formed in the SiC-Al 2 O 3 -Pr 2 O 3 system. SiC was compatible with both of them. Pr-silicates of Pr 2 SiO 5 , Pr 2 Si 2 O 7 and Pr 9.33 Si 6 O 26 (H(Pr) apatite type) were formed owing to presence of SiO 2 impurity in the SiC powder. The presence of the SiO 2 extended the ternary system of SiC-Al 2 O 3 -Pr 2 O 3 into a quaternary system of SiC-Al 2 O 3 -SiO 2 -Pr 2 O 3 (Si-Al-Pr-O-C). SiC was compatible with Al 2 O 3 , Pr 2 O 3 and the Pr-silicates. The effect of SiO 2 on the phase relations and liquid phase sintering of SiC ceramics was discussed.

Direitos fundamentais, ponderação e racionalidade jurídica nas decisões judiciais brasileiras: uma leitura a partir de Robert Alexy / Fundamental rights, balancing and legal rationality in brazilian judicial decisions: a reading from Robert Alexy

OpenAIRE

Heletícia Leão de Oliveira

2016-01-01

Este artigo analisa aspectos relevantes da dogmática dos direitos fundamentais e do seu sopesamento a partir do pensamento de Robert Alexy, cuja teoria tenta responder de forma racional e fundamentada as questões axiológicas. Alega-se que a ponderação utilizada pelos tribunais brasileiros foi transformada em um princípio e está longe da fórmula alexyana original, pois ela leva à discricionariedade. Para que as decisões judiciais não sejam acusadas de serem arbitrárias e ilegítimas, é necessár...

Thermodynamic database for the Co-Pr system.

Science.gov (United States)

Zhou, S H; Kramer, M J; Meng, F Q; McCallum, R W; Ott, R T

2016-03-01

In this article, we describe data on (1) compositions for both as-cast and heat treated specimens were summarized in Table 1; (2) the determined enthalpy of mixing of liquid phase is listed in Table 2; (3) thermodynamic database of the Co-Pr system in TDB format for the research articled entitle Chemical partitioning for the Co-Pr system: First-principles, experiments and energetic calculations to investigate the hard magnetic phase W.

Bookshelf (Conceptual Foundations of Modern Particle Physics, by Robert E. Marshak)

International Nuclear Information System (INIS)

Fritzsch, Harald

1994-01-01

Particle physics really began as an independent scientific discipline after the Second World War. Robert Marshak was one of its pioneers on the theoretical front, starting out his career with important contributions on meson theory (together with Hans Bethe). The life of Marshak, who died in December 1992, was intimately interwoven with the post-war development of particle physics. His work on weak interaction theory was an important step towards the formulation of the V-A theory, the main pillar on which the modern electroweak theory rests erected. He is also remembered as the founder of the biennial 'Rochester' conference series (March 1993, page 24). Just before his death Robert Marshak finished writing his book on the concepts of particle physics. The book starts out with an historical account of the development of the field. He divides it into the startup period (1945-60) - the period of meson physics, the physics of strange particles, parity violation etc; the heroic period (1960-1975) when the Standard Model of the electroweak and strong interactions was developed; and finally the period of consolidation and speculation (since 1975). Marshak's recollection of the development of particle physics represents a personal view, worth reading by young researchers, although it does not attempt to provide a complete picture. After the historical chapter Marshak introduces the reader to the basics of quantum field theory (space-time symmetries, global internal symmetries and their breaking, gauge symmetries). Later he turns to a description of QCD and the gauge theory of the electroweak interactions. A whole chapter is devoted to the problems related to anomalies. In the last part of the book Marshak discusses various hypotheses of unifying the strong and electroweak interactions, especially the various facets of the SO(10) theory, followed by a long discussion of the fermion generation problem and of preon models. The book concludes with an extensive

4. VII kell 17 avatakse Haapsalu Evald Okase muuseumis rahvusvaheline klaasinäitus...

Index Scriptorium Estoniae

2004-01-01

Ühtlasi lõpevad II Haapsalu klaasipäevad "Maritima". Korraldaja Kai Koppel. Klaasi puhuvad Rait Parts, Robert Tannahill Kanadast, Sun Hwan Hong Koreast, Kai Koppel. Näitusel näeb eesti klaasikunstnike Mare Saare, Ivo Lille, Rait Präätsa jt. töid

Implementation of Robert's Coping with Labor Algorithm© in a large tertiary care facility.

Science.gov (United States)

Fairchild, Esther; Roberts, Leissa; Zelman, Karen; Michelli, Shelley; Hastings-Tolsma, Marie

2017-07-01

to implement use of Roberts' Coping with Labor Algorithm © (CWLA) with laboring women in a large tertiary care facility. this was a quality improvement project to implement an alternate approach to pain assessment during labor. It included system assessment for change readiness, implementation of the algorithm across a 6-week period, evaluation of usefulness by nursing staff, and determination of sustained change at one month. Stakeholder Theory (Friedman and Miles, 2002) and Deming's (1982) Plan-Do-Check-Act Cycle, as adapted by Roberts et al (2010), provided the framework for project implementation. the project was undertaken on a labor and delivery (L&D) unit of a large tertiary care facility in a southwestern state in the USA. The unit had 19 suites with close to 6000 laboring patients each year. full, part-time, and per diem Registered Nurse (RN) staff (N=80), including a subset (n=18) who served as the pilot group and champions for implementing the change. a majority of RNs held a positive attitude toward use of the CWLA to assess laboring women's coping with the pain of labor as compared to a Numeric Rating Scale (NRS). RNs reported usefulness in using the CWLA with patients from a wide variety of ethnicities. A pre-existing well-developed team which advocated for evidence-based practice on the unit proved to be a significant strength which promoted rapid change in practice. this work provides important knowledge supporting use of the CWLA in a large tertiary care facility and an approach for effectively implementing that change. Strengths identified in this project contributed to rapid implementation and could be emulated in other facilities. Participant reports support usefulness of the CWLA with patients of varied ethnicity. Assessment of change sustainability at 1 and 6 months demonstrated widespread use of the algorithm though long-term determination is yet needed. Copyright © 2017 Elsevier Ltd. All rights reserved.

O planejamento como prática do poder

Directory of Open Access Journals (Sweden)

Lucas Maia dos Santos

2009-12-01

Full Text Available

Este texto visa apresentar uma leitura crítica acerca da prática de planejamento. Não é um esboço histórico, mas tão-somente uma interpretação do planejamento e como este está inserido na lógica de reprodução da sociedade capitalista. Argumenta para tanto que a prática de planejamento é realizada pela instituição estatal. Esta é um produto genuíno das sociedades de classes. O próprio estado tem como base social uma classe específica: a burocracia. Esta defende, dentro dos quadros da sociedade capitalista, os interesses gerais da burguesia, por mais que possa dentro de dadas circunstâncias sociais específicas opor-se a frações da burguesia, mas nunca aos interesses gerais de classe da burguesia. Defendemos que o poder é uma relação de dominação. Como tal, o planejamento é desta maneira uma manifestação da dominação de classe através da regulação do estado. A instituição estatal é desta forma responsável tanto por regularizar a prática do planejamento, quanto em muitos casos executar os planos ela própria. Assim, defende-se neste texto a necessidade de se superar as relações sociais que engendram o planejamento viabilizado pelo estado. Suprime-se assim o próprio planejamento.

Book Review by Daniel Moran of The Iraq War: Strategy, Tactics, and Military Lessons, by Anthony H. Cordesman, and The Iraq War: A Military History, by Williamson Murray and Major General Robert H. Scales

OpenAIRE

Moran, Daniel

2004-01-01

Reviewed: TThe Iraq War: Strategy, Tactics, and Military Lessons, by Anthony H. Cordesman, and The Iraq War: A Military History, by Williamson Murray and Major General Robert H. Scales The United States and its allies went to war against Iraq in 2003, as Williamson Murray and Robert Scales reasonably propose, “to make an example out of Saddam’s regime, for better or worse” (p. 44). Exactly what the war exemplified, and whether the results are better or worse than might have be...