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  1. 20 CFR 229.45 - Employee benefit.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Employee benefit. 229.45 Section 229.45 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT SOCIAL SECURITY OVERALL MINIMUM GUARANTEE Computation of the Overall Minimum Rate § 229.45 Employee benefit. The original...

  2. Phase separation of DMDBS from iPP, and controlled crystalline orientation

    Science.gov (United States)

    Sreenivas, K.; Kumaraswamy, Guruswamy; Basargekar, R. S.

    2012-02-01

    We report an unexpected dependence of DMDBS phase separation temperature on the molecular weight of the matrix isotactic polypropylene (iPP). DMDBS crystallizes out at lower temperatures for iPP with decreasing molecular weight (and correspondingly lower tacticity). This molecular weight dependence is unique to iPP, and is not observed for either syndiotactic PP or for random ethylene-PP copolymers. We show that thermodynamic Flory-type arguments are unable to rationalize the observed results. We also results on extrusion film casting of iPP containing DMDBS and show that flow-alignment of DMDBS networks template the orientation of PP crystals. The modulus and yield strength increase on addition of DMDBS, relative to the neat iPP. Tensile modulus and yield stress of drawn films increase with the degree of orientation, and we are able to achieve a substantial increase even at relatively low draw ratios.

  3. pp and ̄pp elastic scattering

    Directory of Open Access Journals (Sweden)

    A. Donnachie

    1984-01-01

    Full Text Available We present an analysis of pp and ̄pp elastic scattering in terms of various exchanges. Three-gluon exchange dominates at large t, and single-pomeron exchange at small t. The dip seen in high-energy pp scattering is provided by the interference of both of these with double-pomeron exchange. We predict that this dip will not be found in high-energy ̄pp scattering. The dip that is seen in low-energy ̄pp scattering is the result of the additional presence of reggeon-pomeron exchange.

  4. PP2A-Mediated Anticancer Therapy

    Directory of Open Access Journals (Sweden)

    Weibo Chen

    2013-01-01

    Full Text Available PP2A is a family of mammalian serine/threonine phosphatases that is involved in the control of many cellular functions including protein synthesis, cellular signaling, cell cycle determination, apoptosis, metabolism, and stress responses through the negative regulation of signaling pathways initiated by protein kinases. Rapid progress is being made in the understanding of PP2A complex and its functions. Emerging studies have correlated changes in PP2A with human diseases, especially cancer. PP2A is comprised of 3 subunits: a catalytic subunit, a scaffolding subunit, and a regulatory subunit. The alternations of the subunits have been shown to be in association with many human malignancies. Therapeutic agents targeting PP2A inhibitors or activating PP2A directly have shed light on the therapy of cancers. This review focuses on PP2A structure, cancer-associated mutations, and the targeting of PP2A-related molecules to restore or reactivate PP2A in anticancer therapy, especially in digestive system cancer therapy.

  5. Study of pp{yields}pp{eta} reaction at threshold; Etude de la reaction pp{yields}pp{eta} au seuil

    Energy Technology Data Exchange (ETDEWEB)

    Taleb, A

    1994-11-01

    The {eta} production has been studied through the pp {yields} pp{eta} reaction at threshold. Data were taken at the Synchrotron of the ``Laboratoire National Saturne``. The detection in coincidence of the two protons scattered near 0 deg and analysed with the magnetic spectrometer SPES3 allows the reconstruction of missing mass spectra for the {eta} signature. A simulation program which takes into account all the experimental set up characteristics has been realized and tested through the pp {yields} d{pi}{sup +} reaction detected simultaneously with pp {yields} pp{eta}. The generated proton momentum spectra for pp {yields} pp{eta} show a pronounced {eta} mass dependence. This characteristic, connected to the kinematical properties of pp {yields} pp{eta} at threshold, is used to extract the mass of the meson {eta}. The obtained value, m{sub {eta}} = 547.65 {+-} 0.18 MeV, is in good agreement with measurement done recently through the pd {yields} {sup H}e{eta} reaction. The total cross section {sigma}{sub t} of pp {yields} pp{eta} measured at 1260, 1265 and 1300 MeV presents a strong energy dependence. This cross section increases less with energy than the phase-space. The influence of p-p and {eta}-p final state interactions in our measurements is studied. Our results are compared with theoretical predictions and assess the dominant character of the baryonic resonance N{sup *}(1535) in the {eta} mechanism production at threshold. These experimental results give an energy dependence which is not well reproduced by the theoretical predictions. This discrepancy could be an incorrect description of the {eta}-p interaction in the models. (author). 48 refs., 60 figs., 15 tabs.

  6. Irradiation effect on PP/PMMA and PP/PP-g-PMMA matrices

    International Nuclear Information System (INIS)

    Marsongko; Soebianto, Yanti S.

    1998-01-01

    The effects of PMMA and PP-g-PMMA on the oxidation of polypropylene (PP) have been studied. The mixing was done in Laboplastomill at the temperature of 200 o C, and screw speed of 20 rpm, for 5 minutes. The PMMA concentrations were 1, 2, 5, and 10% by weight, and PP-g-PMMA (12% grafting) 5, 10, and 20% by weight. Mechanical properties (tensile strength (Tb) and elongation at break (Eb)( of the mixture decreased with the increase of PMMA content over 5%. The addition of PMMA over 3% produced non-transparent film. Electron beam irradiation at the dose of 5, 10, 30, and 50 kGy was carried out to accelerate the matrix oxidation is accelerated. The optimum properties of PP/PMMA blends can be achieved by addition of maximum 2% PMMA either direct as PMMA or as compatibilizer (PP-g-PMMA). (authors)

  7. Biocontrol of Pectobacterium carotovorum subsp. carotovorum using bacteriophage PP1.

    Science.gov (United States)

    Lim, Jeong-A; Jee, Samnyu; Lee, Dong Hwan; Roh, Eunjung; Jung, Kyusuk; Oh, Changsik; Heu, Sunggi

    2013-08-01

    Pectobacterium carotovorum subsp. carotovorum (formerly Erwinia carotovora subsp. carotovora) is a plant pathogen that causes soft rot and stem rot diseases in several crops, including Chinese cabbage, potato, and tomato. To control this bacterium, we isolated a bacteriophage, PP1, with lytic activity against P. carotovorum subsp. carotovorum. Transmission electron microscopy revealed that the PP1 phage belongs to the Podoviridae family of the order Caudovirales, which exhibit icosahedral heads and short non-contractile tails. PP1 phage showed high specificity for P. carotovorum subsp. carotovorum, and several bacteria belonging to different species and phyla were resistant to PP1. This phage showed rapid and strong lytic activity against its host bacteria in liquid medium and was stable over a broad range of pH values. Disease caused by P. carotovorum subsp. carotovorum was significantly reduced by PP1 treatment. Overall, PP1 bacteriophage effectively controls P. carotovorum subsp. carotovorum.

  8. The Cloning and Functional Characterization of Peach CONSTANS and FLOWERING LOCUS T Homologous Genes PpCO and PpFT.

    Directory of Open Access Journals (Sweden)

    Xiang Zhang

    Full Text Available Flowering is an essential stage of plant growth and development. The successful transition to flowering not only ensures the completion of plant life cycles, it also serves as the basis for the production of economically important seeds and fruits. CONSTANS (CO and FLOWERING LOCUS T (FT are two genes playing critical roles in flowering time control in Arabidopsis. Through homology-based cloning and rapid-amplifications of cDNA ends (RACE, we obtained full-lengths cDNA sequences of Prunus persica CO (PpCO and Prunus persica FT (PpFT from peach (Prunus persica (L. Batsch and investigated their functions in flowering time regulation. PpCO and PpFT showed high homologies to Arabidopsis CO and FT at DNA, mRNA and protein levels. We showed that PpCO and PpFT were nucleus-localized and both showed transcriptional activation activities in yeast cells, consistent with their potential roles as transcription activators. Moreover, we established that the over-expression of PpCO could restore the late flowering phenotype of the Arabidopsis co-2 mutant, and the late flowering defect of the Arabidopsis ft-1 mutant can be rescued by the over-expression of PpFT, suggesting functional conservations of CO and FT genes in peach and Arabidopsis. Our results suggest that PpCO and PpFT are homologous genes of CO and FT in peach and they may function in regulating plant flowering time.

  9. Molecular mechanism of serine/threonine protein phosphatase 1 (PP1cα-PP1r7) in spermatogenesis of Toxocara canis.

    Science.gov (United States)

    Ma, Guang Xu; Zhou, Rong Qiong; Song, Zhen Hui; Zhu, Hong Hong; Zhou, Zuo Yong; Zeng, Yuan Qin

    2015-09-01

    Toxocariasis is one of the most important, but neglected, zoonoses, which is mainly caused by Toxocara canis. To better understand the role of serine/threonine protein phosphatase 1 (PP1) in reproductive processes of male adult T. canis, differential expression analysis was used to reveal the profiles of PP1 catalytic subunit α (PP1cα) gene Tc-stp-1 and PP1 regulatory subunit 7 (PP1r7) gene TcM-1309. Indirect fluorescence immunocytochemistry was carried out to determine the subcellular distribution of PP1cα. Double-stranded RNA interference (RNAi) assays were employed to illustrate the function and mechanism of PP1cα in male adult reproduction. Real-time quantitative PCR (qPCR) showed transcriptional consistency of Tc-stp-1 and TcM-1309 in sperm-producing germline tissues and localization research showed cytoplasmic distribution of PP1cα in sf9 cells, which indicated relevant involvements of PP1cα and PP1r7 in spermatogenesis. Moreover, spatiotemporal transcriptional differences of Tc-stp-1 were determined by gene knockdown analysis, which revealed abnormal morphologies and blocked meiotic divisions of spermatocytes by phenotypic aberration scanning, thereby highlighting the crucial involvement of PP1cα in spermatogenesis. These results revealed a PP1cα-PP1r7 mechanism by which PP1 regulates kinetochore-microtubule interactions in spermatogenesis and provided important clues to identify novel drug or vaccine targets for toxocariasis control. Copyright © 2015 Elsevier B.V. All rights reserved.

  10. Methylation-regulated decommissioning of multimeric PP2A complexes

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Cheng-Guo; Zheng, Aiping; Jiang, Li; Rowse, Michael; Stanevich, Vitali; Chen, Hui; Li, Yitong; Satyshur, Kenneth A.; Johnson, Benjamin; Gu, Ting-Jia; Liu, Zuojia; Xing, Yongna

    2017-12-01

    Dynamic assembly/disassembly of signaling complexes are crucial for cellular functions. Specialized latency and activation chaperones control the biogenesis of protein phosphatase 2A (PP2A) holoenzymes that contain a common scaffold and catalytic subunits and a variable regulatory subunit. Here we show that the butterfly-shaped TIPRL (TOR signaling pathway regulator) makes highly integrative multibranching contacts with the PP2A catalytic subunit, selective for the unmethylated tail and perturbing/inactivating the phosphatase active site. TIPRL also makes unusual wobble contacts with the scaffold subunit, allowing TIPRL, but not the overlapping regulatory subunits, to tolerate disease-associated PP2A mutations, resulting in reduced holoenzyme assembly and enhanced inactivation of mutant PP2A. Strikingly, TIPRL and the latency chaperone, α4, coordinate to disassemble active holoenzymes into latent PP2A, strictly controlled by methylation. Our study reveals a mechanism for methylation-responsive inactivation and holoenzyme disassembly, illustrating the complexity of regulation/signaling, dynamic complex disassembly, and disease mutations in cancer and intellectual disability.

  11. ONKALO pose experiment. Geophysical logging and imaging of drillholes ONK-PP223, ONK-PP226, ONK-PP254 and ONK-PP259...261

    International Nuclear Information System (INIS)

    Tarvainen, A.-M.

    2011-08-01

    Suomen Malmi Oy conducted geophysical drillhole logging as well as optical and acoustic imaging of shallow drillholes ONK-PP223, ONK-PP226, ONK-PP254, ONKPP259, ONK-PP260 and ONK-PP261 at ONKALO in the investigation niche ONKTKU- 3 (POSE) between December 2009 and June 2010. The survey is a part of Posiva Oy's detailed investigation program for the final disposal of spent nuclear fuel. The assignment included the field work and data processing. The report describes field operation, equipment as well as processing procedures and shows the obtained results and an analysis of their quality in the appendices. The raw and processed data are delivered digitally in WellCAD, PDF and Excel format. (orig.)

  12. The Distinction of Amyloid-β Protein Precursor (AβPP) Ratio in Platelet Between Alzheimer's Disease Patients and Controls: A Systematic Review and Meta-Analysis.

    Science.gov (United States)

    Shi, Yachen; Gu, Lihua; Alsharif, Abdul Azeez; Zhang, Zhijun

    2017-01-01

    To systematically assess the clinical significance of platelet amyloid-β protein precursor (AβPP) ratio between Alzheimer's disease (AD) patients and controls. 14 articles were selected in this analysis by search of databases including PubMed and Web of Science up to December 2016. Random effects models were used to calculate the standardized mean difference (SMD). Subgroup analyses were used to detect the cause of heterogeneity. The result showed a significant drop in platelet AβPP ratio in AD patients compared to controls [SMD: -1.871; 95% CI: (-2.33, -1.41); p analysis revealed races or the quality of studies may be the cause of high heterogeneity. This meta-analysis concluded that there is a close association between platelet AβPP ratio and AD. It is necessary to design a sizable sample study to further support that platelet AβPP ratio can be a biomarker of AD.

  13. pp 1101–111

    Indian Academy of Sciences (India)

    Administrator

    Electronic Supplementary Material. Graphical abstract. Preparation and characterization of monosubstituted porphyrins immobilized on nanosilica by Ebrahim Ahmadi et al (pp 1101–1112). N-(3-triethoxysilylpropyl)-4-formyl benzamide (Aldehyde (1)), that bears a Si(OEt)3 group, was anchored to silica support by controlled ...

  14. Heterogenous expression of Pyrus pyrifolia PpCAD2 and PpEXP2 in tobacco impacts lignin accumulation in transgenic plants.

    Science.gov (United States)

    Wang, Yuling; Zhang, Xinfu; Yang, Shaolan; Wang, Caihong; Lu, Guilong; Wang, Ran; Yang, Yingjie; Li, Dingli

    2017-12-30

    Lignin, a natural macromolecular compound, plays an important role in the texture and taste of fruit. Hard end is a physiological disorder of pear fruit, in which the level of lignification in fruit tissues is dramatically elevated. Cinnamyl alcohol dehydrogenase and expansin genes (PpCAD2 and PpEXP2, respectively) exhibit higher levels of expression in 'Whangkeumbae' (Pyrus pyrifolia) pear fruit exhibiting this physiological disorder, relative to control fruit without symptoms. These genes were isolated from pear fruit and subsequently expressed in tobacco (Nicotiana tabacum) to investigate their function. Histochemical staining for lignin revealed that the degree of lignification in leaf veins and stem tissues increased in plants transformed with sense constructs and decreased in plants transformed with antisense constructs of PpCAD2. The expression of native NtCADs was also inhibited in the antisense PpCAD2 transgenic tobacco. Sense and antisense PpCAD2 transgenic tobacco exhibited an 86.7% increase and a 60% decrease in CAD activity, respectively, accompanied by a complementary response in lignin content in root tissues. The basal portion of the stem in PpEXP2 transgenic tobacco was bent and highly lignified. Additionally, the level of cellulose also increased in the stem of PpEXP2 transgenic tobacco. Collectively, these results suggested that PpCAD2 and PpEXP2 genes play a significant role in lignin accumulation in transgenic tobacco plants, and it is inferred that these two genes may also participate in the increased lignification observed in hard end pear fruit. Copyright © 2017. Published by Elsevier B.V.

  15. Progesterone-associated proteins PP12 and PP14 in the human endometrium.

    Science.gov (United States)

    Rutanen, E M; Koistinen, R; Seppälä, M; Julkunen, M; Suikkari, A M; Huhtala, M L

    1987-01-01

    Two proteins, designated as PP12 and PP14 were originally isolated from soluble extracts of the human placenta and its adjacent membranes. We have shown that they are synthesized by decidualized/secretory endometrium and not by placenta. Both proteins occur at high concentrations in human amniotic fluid, which is therefore an excellent source for purification. PP12 is a 34-kDa glycoprotein, which has an N-terminal amino acid sequence of Ala-Pro-Trp-Gln-Cys-Ala-Pro-Cys-Ser-Ala. This is identical with that of somatomedin-binding protein purified from the amniotic fluid. PP12 too binds somatomedin-C, or IGF-I (insulin-like growth factor-I). Human secretory endometrium synthesizes and secretes PP12, and progesterone stimulates its secretion. PP14 is a 28-kDa glycoprotein. Its N-terminal sequence shows homology to that of beta-lactoglobulins from various species. We have found PP14 in the human endometrium, serum and milk. Immunologically, PP14 is related to progestagen-associated endometrial protein (PEP), alpha-2 pregnancy-associated endometrial protein (alpha-2, PEG), endometrial protein 15 (EP15), alpha-uterine protein (AUP) and chorionic alpha-2 microglobulin (CAG-2). In ovulatory menstrual cycles, the concentration of PP14 increases in endometrial tissue as the secretory changes advance. In serum, the PP14 concentration begins to rise later than the progesterone levels, and high serum PP14 levels are maintained for the first days of the next cycle. By contrast, no elevation of serum PP14 level is seen in anovulatory cycles. Our results show that progesterone-associated proteins are synthesized by the human endometrium and appear in the peripheral circulation, where they can be quantitatively measured using immunochemical techniques.

  16. Effect of tocopherols incorporation on physical properties of LDPE,PP and blend film of LDPE/PP

    Directory of Open Access Journals (Sweden)

    ZHU Xuntao

    2014-12-01

    Full Text Available The objectives of this study were to investigate the effects of added tocopherols and blending of different polymers on the film physical properties.Tocopherols (3 000 mg/kg were incorporate into low density polyethylene (LDPE,polypropylene (PP and a blend film of LDPE/PP (50/50 by extrusion process.Then films were evaluated to determine tocopherol recovery and physical properties.Results showed that extrusion did not significantly change film thermal properties (Tm,Tc and Tg as compared with synthetic polymer resin pellet (raw material.LDPE and PP did not seem to react with each other to form new polymers under the current extrusion conditions.Addition of tocopherol significantly changed film mechanical properties compared with control.The above results and other data seemed to support that polymer blending is a feasible approach for producing tocopherol containing packaging films.

  17. The PP1 binding code: a molecular-lego strategy that governs specificity.

    Science.gov (United States)

    Heroes, Ewald; Lesage, Bart; Görnemann, Janina; Beullens, Monique; Van Meervelt, Luc; Bollen, Mathieu

    2013-01-01

    Ser/Thr protein phosphatase 1 (PP1) is a single-domain hub protein with nearly 200 validated interactors in vertebrates. PP1-interacting proteins (PIPs) are ubiquitously expressed but show an exceptional diversity in brain, testis and white blood cells. The binding of PIPs is mainly mediated by short motifs that dock to surface grooves of PP1. Although PIPs often contain variants of the same PP1 binding motifs, they differ in the number and combination of docking sites. This molecular-lego strategy for binding to PP1 creates holoenzymes with unique properties. The PP1 binding code can be described as specific, universal, degenerate, nonexclusive and dynamic. PIPs control associated PP1 by interference with substrate recruitment or access to the active site. In addition, some PIPs have a subcellular targeting domain that promotes dephosphorylation by increasing the local concentration of PP1. The diversity of the PP1 interactome and the properties of the PP1 binding code account for the exquisite specificity of PP1 in vivo. © 2012 The Authors Journal compilation © 2012 FEBS.

  18. ONKALO POSE experiment. Determination of in situ thermal properties of rocks in drillholes ONK-PP340, ONK-PP346, ONK-PP398, ONK-PP399, ONK-PP405, ONK-PP411

    International Nuclear Information System (INIS)

    Korpisalo, A.; Suppala, I.; Kukkonen, I.; Koskinen, T.

    2014-12-01

    The thermal drillhole device TERO76 (for diameter 76 mm drillholes) used in this study for determining thermal properties of rocks in situ was developed at the Geological Survey of Finland for Posiva in the early 2000's. The measurement method is based on monitoring the temperature variation of a cylindrical heating source in a drillhole. The measured data can be interpreted with full numerical 3D codes as well as with an analytical infinite line source method, a 'rapid interpretation tool', which makes it possible to calculate the first estimates of thermal properties already in the field. Both methods were applied in this study. Because of the unique measurement geometry, only the thermal conductivities can accurately be estimated using the late times of heating periods (accuracy ± 2%). The cylindrical source method cannot directly give the thermal diffusivity or volumetric heat capacity at a sufficient accuracy. Thermal diffusivities are estimated by using the average specific heat capacities and densities of the rock type at the measurement point, or the laboratory results on the general diffusivity-conductivity relationship for different Olkiluoto rock types. The latter technique was applied in this study. Thermal properties were determined in four shallow drillholes (ONK-PP398, ONK-PP399, ONK-PP405, ONK-PP411) located in the ONKALO investigation niche 3 (ONK-TKU-3620) at the access tunnel chainage of 3620 m. The measurement positions (17) were strictly selected on the grounds that approximately an equal number of in situ results would be available in both veined gneiss (VGN) and pegmatitic granite (PGR). The results from the drillholes ONK-PP340 and ONK-PP346 measured in a previous project are also presented in this report. In veined gneiss, the average conductivity determined with numerical model of the present measurements is 3.49 (2.83) Wm -1 K -1 and diffusivity 1.89 x 10 -6 (1.3 10 -6 ) m 2 s -1 . The laboratory values of Olkiluoto rocks

  19. A comparison of pp and pp elastic scattering at 90 degrees

    CERN Document Server

    Eisenhandler, E F; Astbury, A; Gibson, W R; Harrison, M; Hojvat, C; Jones, D P; Kalmus, Peter I P; Kemp, M A R; Lee Chi Kwong, L; Parsons, A S L; Pritchard, T W; Range, W H; Rush, A D; Usher, E C; Williams, D T; Woulds, J N

    1974-01-01

    A study of low momentum antiproton-proton interactions in the momentum range 0.7 to 2.4 GeV/c has yielded differential cross sections for the elastic channel. An observation of one property of the data when compared with pp elastic scattering within the framework of quark- parton models is presented. The pp and pp systems, related by crossing symmetry, provided significant constraints on any particular model. (13 refs).

  20. 1972, pp. 136. 76

    African Journals Online (AJOL)

    WERNER MASER: Adolf Hitler. legende, mythe, werkelijkheid. Uitgeverij De Arbeiders- pers, Amsterdam, 1973, pp. 531. Met aante- keninge [pp. 429 -. 506] en bibliografie. [pp. 507 - 531]. In 1945 het die skrywer van hierdie studie, op grond van 'n proefskrif oor die doelbewuste aankweek van die Hitlerlegende tot 1924,.

  1. Photooxidation behaviour of HMS-PP

    International Nuclear Information System (INIS)

    Oliani, Washington L.; Parra, Duclerc F.; Lima, Luis F.C.P.; Lugao, Ademar B.

    2009-01-01

    The radiation process has played an important role to produce polymers with controlled rheological properties. The main scope of the study is to evaluate the stability of High melt strength polypropylene (HMS-PP) prepared by gamma irradiation of PP (spheres) under acetylene atmosphere followed by a heating step to terminate reactions, in different doses of 12.5 kGy and 20 kGy. The samples submitted to the natural ageing for a period of one year were characterized by: thermogravimetry (TG), differential scanning calorimetry (DSC), infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The fundamental process that is believed to be the most significant in the mechanism of photooxidative degradation is the formation of hydroperoxides. The high energy UV light is capable of initiating bond scission within the polymer backbone, which leads to further chemical modification of the bonds via scissions and chain reactions through formation of radical species. The results showed that in pristine and HMS-PP samples exposed to UV radiation, oxidation reactions occur, resulting in chain scissions. The reactions occur preferentially in the amorphous phase owing to the higher permeability of oxygen. (author)

  2. PP-O and PP-V, Monascus pigment homologues, production, and phylogenetic analysis in Penicillium purpurogenum.

    Science.gov (United States)

    Arai, Teppei; Kojima, Ryo; Motegi, Yoshiki; Kato, Jun; Kasumi, Takafumi; Ogihara, Jun

    2015-12-01

    The production of pigments as secondary metabolites by microbes is known to vary by species and by physiological conditions within a single strain. The fungus strain Penicillium purpurogenum IAM15392 has been found to produce violet pigment (PP-V) and orange pigment (PP-O),Monascus azaphilone pigment homologues, when grown under specific culture conditions. In this study, we analysed PP-V and PP-O production capability in seven strains of P. purpurogenum in addition to strain IAM15392 under specific culture conditions. The pigment production pattern of five strains cultivated in PP-V production medium was similar to that of strain IAM15392, and all violet pigments produced by these five strains were confirmed to be PP-V. Strains that did not produce pigment were also identified. In addition, two strains cultivated in PP-O production medium produced a violet pigment identified as PP-V. The ribosomal DNA (rDNA) internal transcribed spacer (ITS) region sequences from the eight P. purpurogenum strains were sequenced and used to construct a neighbor-joining phylogenetic tree. PP-O and PP-V production of P. purpurogenum was shown to be related to phylogenetic placement based on rDNA ITS sequence. Based on these results, two hypotheses for the alteration of pigment production of P. purpurogenum in evolution were proposed. Copyright © 2015 The British Mycological Society. Published by Elsevier Ltd. All rights reserved.

  3. Finsler pp-waves

    NARCIS (Netherlands)

    Fuster, A.; Pabst, C.

    2015-01-01

    In this work we present a Finslerian version of the well-known pp-waves, which generalizes the very special relativity (VSR) line element. Our Finsler pp-waves are an exact solution of Finslerian Einstein's equations in vacuum.

  4. Gluon ladders in pp (pp-bar) collisions

    International Nuclear Information System (INIS)

    Machado, Magno Valerio Trindade; Ducati, Maria Beatriz Gay

    2000-01-01

    Full text follows: We study the contribution of a finite sum of gluon ladders to the hadronic processes showing that a reliable description is obtained using two order on perturbation theory. The pp(pp-bar) total cross sections are described with good agreement, consistent with unitarity bound. We also calculate the elastic scattering amplitude at non zero momentum transfer t, introducing two distinct Ansatz for the proton impact factor. As a by product the elastic differential cross section is obtained at small t approximation and compared with the data. (author)

  5. Flow measurements and hydraulic interference tests at the Olkiluoto site in Eurajoki, drillholes OL-KR14, OL-KR30, OL-PP66, OL-PP67, OL-PP68 and OL-PP69

    Energy Technology Data Exchange (ETDEWEB)

    Komulainen, J. [Poeyry Finland Oy, Vantaa (Finland)

    2014-08-15

    The measurements described in this report are part of the infiltration experiment carried out at Olkiluoto. The emphasis of these measurements is on obtaining more detailed data on hydraulically significant fractures in the infiltration experiment area. The selected fractures or sections were pumped in turn and flow responses were observed in the other holes by the PFL DIFF-tool. The flow measurements were carried out in drillholes OL-KR14, OL-KR30, OL-PP66, OL-PP67, OL-PP68 and OL-PP69 on the Olkiluoto investigation site between January 2013 and July 2013. Two different flowmeters were used for the measurements. Posiva Flow Log, Difference flow method (PFL DIFF) was used for the determination of hydraulic conductivity and hydraulic head in fractures/fractured zones in the drillholes. PFL DIFF flow logging was conducted in all the drillholes mentioned above. Posiva Flow Log, Transverse flow method (PFL TRANS) was used to determine groundwater flow direction and flow rate across a drillhole. The transverse flow method was used in drillholes OL-KR14 and OL-PP69. PFL DIFF and PFL TRANS measurements had been carried out earlier in drillholes OL-PP66, OL-PP67, OL-PP68 and OL-PP69. The most recent measurements were conducted in 2011. Those measurements were carried out when drillhole OL-KR14 was pumped at packed-off section 13 m - 18 m. Both PFL DIFF and PFL TRANS flowmeters include an electrode for measuring single point resistance (SPR). The device has a high depth resolution and the results were used for depth synchronisation between consecutive DIFF and TRANS measurements. (orig.)

  6. Lanthanum Containing Polymer's Modification to PP

    Institute of Scientific and Technical Information of China (English)

    Dai Shaojun; Zhang Ming

    2004-01-01

    Polypropylene (PP)'s low impact strength limits its usages. Adding some a rare earth polymer can enhance PP's tensile strength and impact strength. Acrylic lanthanum was prepared by the reaction between lanthanum oxide and acrylic acid. The IR spectrum prove that and optimum reacting conditions are that the bulk ratio of La(AA) 3 and MMA is not less than one and temperature is about 80 ℃. Lanthanum containing Polymer were added into PP. When percent of addition only was 3%, strength were enhanced 10% , and impact strength 40%. SEM shows the compatibility of rare earth polymer and PP; lanthanum containing polymer can form physical crosslinking between PP's molecules, then every particle's surface connect with several PP molecules and the PP mechanical property were enhanced.

  7. Nuclear trafficking of the human cytomegalovirus pp71 (ppUL82) tegument protein

    International Nuclear Information System (INIS)

    Shen Weiping; Westgard, Elizabeth; Huang Liqun; Ward, Michael D.; Osborn, Jodi L.; Chau, Nha H.; Collins, Lindsay; Marcum, Benjamin; Koach, Margaret A.; Bibbs, Jennifer; Semmes, O. John; Kerry, Julie A.

    2008-01-01

    The human cytomegalovirus tegument protein pp71 localizes to the nucleus immediately upon infection, and functions to initiate viral gene expression. Analysis of a series of random insertion mutations revealed that sequences within the mid region (MR) of pp71 are important for localization to the nucleus. Fusion of MR sequences with eGFP revealed that amino acids 94 to 300 were sufficient to target proteins to the nucleus. Random substitution mutagenesis within this domain resulted in two double substitution mutants, pp71P203T/T223M and pp71T228M/L275Q, with a predominantly cytoplasmic localization. Disruption of nuclear targeting resulted in relocalization of the fusion proteins to a distinct perinuclear region. Using tandem mass spectrometry, we determined that threonine 223 can be phosphorylated. Mutation of this residue to a phosphomimetic amino acid resulted in abrogation of nuclear targeting. These results strongly suggest that the intracellular trafficking of pp71 is regulated by phosphorylation

  8. Analysis of pp and pp-bar elastic scattering amplitudes at high energies

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, E.; Kodama, T.; Kohara, A.K. [Universidade Federal do Rio de Janeiro (IF/UFRJ), RJ (Brazil). Inst. de Fisica

    2012-07-01

    Full text: A careful analysis of high energies elastic scattering data at 7 TeV for pp, 1800 - 1950 GeV for pp-bar and 540 -541 GeV for pp-bar in terms of its amplitudes has been performed as natural extension of previous analysis for lower energies. The disentanglement of the real and imaginary parts is written consistently with constraints from dispersion relations for amplitudes and for slopes, and also satisfying the universal asymptotic behavior for large |t| values due to the three gluon Exchange process. Values for the imaginary and real slopes and for the total cross section at 7 TeV, 1800-1950 GeV and 540-541 GeV are presented, and the shape of the differential cross section at 14 TeV, with a dip/bump structure more marked and at a smaller values of |t| is predicted. It is predicted that future measurements at large |t| will be connected smoothly with the perturbative tail observed in the interval 5.5 to 14.2 GeV{sup 2} at lower energies and that a marked dip would be observed in pp-bar scattering near this tail range. It is stressed for the consistent description of elastic pp and pp-bar data and pointed out the importance of the future measurements in the Coulomb interference range and in the transition range to the perturbative tail where the perturbative and non-perturbative effects appears together. (author)

  9. Spinning, structure and properties of PP/CNTs and PP/carbon black composite fibers

    Science.gov (United States)

    Marcincin, A.; Hricova, M.; Ujhelyiova, A.

    2014-08-01

    In this paper, the effect of the compatibilisers-dispersants and other nanofillers on melt spinning of the polypropylene (PP) composites, containing carbon nanotubes (CNTs), and carbon black pigment (CBP) has been investigated. Further, the structure and selected properties of composite fibers, such as mechanical and electrical have been studied. The results revealed, that percolation threshold for PP/CBP composite fibres was situated within the concentration of 15 - 20 wt%, what is several times higher than for PP/CNTs fibers.

  10. ISAJET: a Monte Carlo event generator for pp and anti pp interactions

    International Nuclear Information System (INIS)

    Paige, F.E.; Protopopescu, S.D.

    1985-01-01

    ISAJET is a Monte Carlo program which simulates pp and anti pp interactions at high energy. It is based on perturbative QCD plus phenomenological models for jet and beam jet fragmentation. This article describes ISAJET Version 5.00. 21 refs., 3 figs

  11. Properties of PP/MWCNT-COOH /PP composites made by melt mixing versus solution cast /melt mixing methods

    International Nuclear Information System (INIS)

    Reinholds, I; Roja, Z; Zicans, J; Meri, R Merijs; Bitenieks, J

    2015-01-01

    An approach on improvement of the properties of polypropylene / carbon nanotube (PP/CNT) composites is reported. PP blend compositions with carboxylic acid functionalized multi-walled carbon nanotubes (MWCNT-COOH) at filler content 1.0 wt.% were researched. One part of the composites was manufactured by direct thermoplastic mixing PP with the filler, but the other one was made from solution casted masterbatch with the following thermoplastic mixing. An increase of mechanical properties (Young's modulus, storage modulus and tensile strength), compared to an increase of glass transition temperature indicated a reinforcement effect of CNTs on PP matrix, determined from the tensile tests and differential mechanical analysis (DMA), while the elongation was reduced, compared to PP matrix. By differential scanning calorimetry (DSC) analysis, the effect of nanofiller on the reorganization of PP crystallites was observed. A noticeable enhanced effect on increase of the crystallization temperature was indicated for masterbatch manufactured composite. An increase of thermal stability was also observed, compared to pristine PP and the composite made by direct thermoplastic mixing PP with the filler

  12. Quantitative phosphoproteomics reveals new roles for the protein phosphatase PP6 in mitotic cells.

    Science.gov (United States)

    Rusin, Scott F; Schlosser, Kate A; Adamo, Mark E; Kettenbach, Arminja N

    2015-10-13

    Protein phosphorylation is an important regulatory mechanism controlling mitotic progression. Protein phosphatase 6 (PP6) is an essential enzyme with conserved roles in chromosome segregation and spindle assembly from yeast to humans. We applied a baculovirus-mediated gene silencing approach to deplete HeLa cells of the catalytic subunit of PP6 (PP6c) and analyzed changes in the phosphoproteome and proteome in mitotic cells by quantitative mass spectrometry-based proteomics. We identified 408 phosphopeptides on 272 proteins that increased and 298 phosphopeptides on 220 proteins that decreased in phosphorylation upon PP6c depletion in mitotic cells. Motif analysis of the phosphorylated sites combined with bioinformatics pathway analysis revealed previously unknown PP6c-dependent regulatory pathways. Biochemical assays demonstrated that PP6c opposed casein kinase 2-dependent phosphorylation of the condensin I subunit NCAP-G, and cellular analysis showed that depletion of PP6c resulted in defects in chromosome condensation and segregation in anaphase, consistent with dysregulation of condensin I function in the absence of PP6 activity. Copyright © 2015, American Association for the Advancement of Science.

  13. GridPP returns to CERN

    CERN Document Server

    Neasan O'Neill

    2011-01-01

    In early September, GridPP, the collaboration that manages the UK’s contribution to the worldwide LHC Computing Grid (wLCG), celebrated a decade of work by holding its twenty-seventh collaboration meeting at CERN.   Officially launched in September 2001, GridPP was one of the original partners in wLCG, funding much of the early work at CERN. Over the last decade GridPP has gone from a mere proposal to almost 30,000 CPUs working for researchers scattered across the globe. Twice a year, GridPP meets to discuss the progress and future plans of the community and this year, for the first time since 2004, decamped to CERN for this biannual meeting on the theme “GridPP in the International Context”. The main meeting was held over 2 days in the IT auditorium and was the perfect opportunity to have contributions from experts based at CERN, alongside those from within GridPP. Opening with a welcome from Frederic Hemmer, Head of the IT Department at CERN, the meeting began with...

  14. Polarization measurements in the pp → pnπ+ and ppppπ0 reactions at 517 and 580 MeV

    International Nuclear Information System (INIS)

    Bach, P.; Cantale, G.; Degli-Agosti, S.; Demierre, P.; Favier, B.; Heer, E.; Hess, R.; Lechanoine-Leluc, C.; Leo, W.; Onel, Y.; and others.

    1989-01-01

    The transverse polarization of the outgoing proton in the pp → pnπ + and ppppπ 0 reactions was investigated for the first time. The measurements were performed at SIN (now PSI) at 517 and 580 MeV on the pM1 polarized proton beam line with an average beam polarization higher than 82%, using a liquid hydrogen target. A carbon polarimeter spin-analyzed the scattered proton, 3 MWPC's tracked the recoil charged particle and a 3.84 m 2 neutron detector identified the neutral particle and measured TOF's

  15. Forward diffraction amplitude of pp and pp elastic scattering at accelerator energies

    International Nuclear Information System (INIS)

    Kawasaki, M.; Maehara, T.; Yonezawa, M.

    2004-01-01

    A simple relation between the total cross section and the forward exponential slope of the elastic differential cross section of pp and pp scattering is indicated. An interpretation of this relation is presented as the formation of a black-disk structure for the elastic diffraction interaction of hadron-hadron scattering at the nonasymptotic energy region

  16. New boundaries for the “ppK−” production in p+p collisions

    Directory of Open Access Journals (Sweden)

    Epple Eliane

    2014-01-01

    Full Text Available The HADES collaboration has searched for the anti-kaonic nuclear cluster “ppK−” in p+p collisions by its decay into pΛ. In the course of this analysis several cross checks had to be performed. This report discusses two examples thereof. In one test it was checked whether the presence of background events could introduce a bias on the applied partial wave analysis. The second item discussed here is the extraction of the total pK+Λ production cross section necessary to derive the absolute upper limit on the “ppK−” production cross section.

  17. anti pp and pp elastic scattering from 10 GeV to 1000 GeV centre-of-mass energy

    Energy Technology Data Exchange (ETDEWEB)

    Islam, M.M. (Connecticut Univ., Storrs (USA). Dept. of Physics); Fearnley, T. (University Coll., London (UK). Dept. of Physics and Astronomy); Guillaud, J.P. (Grenoble-1 Univ., 74 - Annecy (France). Lab. de Physique des Particules)

    1984-06-21

    Antiproton-proton and proton-proton elastic scattering are studied simultaneously over the energy range ..sqrt..anti s approx.= (10/1000) GeV in a nucleon valence core model proposed earlier. The scattering is described as primarily due to two processes: diffraction and hard scattering. The latter originates from the scattering of a nucleon core off another core. Destructive interference between the two processes produces dips in anti pp and pp differential cross-sections. As energy increases beyond the ISR range (..sqrt..anti s = (23/62) GeV), the dips get filled up, and eventually transform into shoulders or breaks at collider energies. Differences between anti pp and pp differential cross-sections persist even at collider energies. Comparison with ISR data shows that the model provides a quantitative description of pp elastic scattering in this energy range. Predictions of anti pp and pp differential cross-sections at future collider energies ..sqrt..s = 800 and 2000 GeV are given. In order to distinguish between competing models, need for measuring the anti pp differential cross-section at the ISR and SPS collider in the vertical stroketvertical stroke-range (0.5/2.0) (GeV)/sup 2/ is stressed.

  18. Photooxidation of HMS-PP under environment and artificial weathering conditions;Fotooxidacao do HMS-PP sob condicoes de intemperismo ambiental e artificial

    Energy Technology Data Exchange (ETDEWEB)

    Oliani, Washington L.; Parra, Duclerc F.; Lima, Luis Filipe C.P.; Lugao, Ademar B. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2009-07-01

    The linearity of the chains confers to iPP, low melt strength, which means a low strength to stretching during elongation. The increase of melt strength and the extensibility is due to the increase of the entanglement of the macromolecules chains. The HMS-PP (high melt strength polypropylene) was synthesized (based on the grains iPP) through gamma irradiation in the iPP under acetylene atmosphere followed by heat treatment for recombination and subsequent annihilation of the other free radicals. Samples of HMS-PP and iPP were subjected to environmental aging in IPEN - Sao Paulo and in the QUV chamber. The results show fractured surfaces of iPP and HMS-PP that are intensified with exposure time. The iPP degradation process has the predominance of chain scissions, with carbonyl and hydroperoxides formation which act as initiators of photo degradation mechanisms. (author)

  19. Transcription and translation of phloem protein (PP2) during phloem differentiation in Cucurbita maxima.

    Science.gov (United States)

    Sham, M H; Northcote, D H

    1987-03-01

    The synthesis of a major phloem protein, PP2, was investigated by measurement of the mRNA at various stages of phloem development in Cucurbita. Quantitative assays with immuno-electrophoresis showed that the amounts of PP2 in hypocotyls of Cucurbita seedlings increased with the age of seedlings. An increase in mRNA for PP2 during the early stages of seedling growth was also observed by immunoprecipitation of the invitro translation products of hypocotyl polyadenylated RNA. There was close timing in the variations of PP2 synthesised in vivo and in the changes in amounts of translatable PP2-mRNA during the course of seedling growth. A complementary-DNA (cDNA) library to polyadenylated RNA from hypocotyls of 3-d-old Cucurbita seedlings has been constructed. Two cDNA clones, A and B, have been identified by hybrid-release translation to be complementary to the mRNA coding for PP2. The levels of total mRNA for PP2 measured with clone A were found to increase in the first 4 d of seedling growth but decreased to lower levels in older seedlings. Regulatory controls on both transcription and modification of transcripts appeared to occur during the synthesis of PP2.

  20. Comparison of short-range rapidity correlations in anti pp and pp interactions at √S = 53 GeV

    International Nuclear Information System (INIS)

    Breakstone, A.; Crawley, H.B.; Firestone, A.; Gorbics, M.; Lamsa, J.W.; Meyer, W.T.

    1982-01-01

    Measurements are presented of two-particle rapidity correlations in anti pp and pp at √S = 53 GeV. The data were recorded at the CERN-ISR using the Split Field Magnet spectrometer with a minimum bias trigger. Short range correlations in normal inelastic events with measured charged multiplicities nsub(ch) >= 4 are observed for pairs of charged particles in all charge combinations. Within the experimental errors no differences are observed between the analogous correlations in pp and anti pp interactions. (orig.)

  1. Analysis of pp and pp-bar in forward scattering using derivative dispersion relations

    International Nuclear Information System (INIS)

    Kohara, A. K.; Ferreira, E.; Kodama, T.

    2010-01-01

    We describe the amplitudes for pp and pp-bar scattering at small momentum transfers, where Coulomb and nuclear interference occurs, with special attention to the slopes of the real and imaginary parts. The forward amplitudes are assumed to have simple exponential forms, depending on four parameters σ, ρ, B I , B R , with B I ≠ B R .

  2. PpNAC1, a main regulator of phenylalanine biosynthesis and utilization in maritime pine.

    Science.gov (United States)

    Pascual, María Belén; Llebrés, María-Teresa; Craven-Bartle, Blanca; Cañas, Rafael A; Cánovas, Francisco M; Ávila, Concepción

    2018-05-01

    The transcriptional regulation of phenylalanine metabolism is particularly important in conifers, long-lived species that use large amounts of carbon in wood. Here, we show that the Pinus pinaster transcription factor, PpNAC1, is a main regulator of phenylalanine biosynthesis and utilization. A phylogenetic analysis classified PpNAC1 in the NST proteins group and was selected for functional characterization. PpNAC1 is predominantly expressed in the secondary xylem and compression wood of adult trees. Silencing of PpNAC1 in P. pinaster results in the alteration of stem vascular radial patterning and the down-regulation of several genes associated with cell wall biogenesis and secondary metabolism. Furthermore, transactivation and EMSA analyses showed that PpNAC1 is able to activate its own expression and PpMyb4 promoter, while PpMyb4 is able to activate PpMyb8, a transcriptional regulator of phenylalanine and lignin biosynthesis in maritime pine. Together, these results suggest that PpNAC1 is a functional ortholog of the ArabidopsisSND1 and NST1 genes and support the idea that key regulators governing secondary cell wall formation could be conserved between gymnosperms and angiosperms. Understanding the molecular switches controlling wood formation is of paramount importance for fundamental tree biology and paves the way for applications in conifer biotechnology. © 2017 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.

  3. pp interactions in extended air showers

    Directory of Open Access Journals (Sweden)

    Kendi Kohara A.

    2015-01-01

    Full Text Available Applying the recently constructed analytic representation for the pp scattering amplitudes, we present a study of p-air cross sections, with comparison to the data from Extensive Air Shower (EAS measurements. The amplitudes describe with precision all available accelerator data at ISR, SPS and LHC energies, and its theoretical basis, together with the very smooth energy dependence of parameters controlled by unitarity and dispersion relations, permit reliable extrapolation to higher energies and to asymptotic ranges. The comparison with cosmic ray data is very satisfactory in the whole pp energy interval from 1 to 100 TeV. High energy asymptotic behaviour of cross sections is investigated in view of the geometric scaling property of the amplitudes. The amplitudes predict that the proton does not behave as a black disk even at asymptotically high enegies, and we discuss possible non-trivial consequences of this fact for pA collision cross sections at higher energies.

  4. Study of pp→ppη reaction at threshold

    International Nuclear Information System (INIS)

    Taleb, A.

    1994-11-01

    The η production has been studied through the ppppη reaction at threshold. Data were taken at the Synchrotron of the ''Laboratoire National Saturne''. The detection in coincidence of the two protons scattered near 0 deg and analysed with the magnetic spectrometer SPES3 allows the reconstruction of missing mass spectra for the η signature. A simulation program which takes into account all the experimental set up characteristics has been realized and tested through the pp → dπ + reaction detected simultaneously with ppppη. The generated proton momentum spectra for ppppη show a pronounced η mass dependence. This characteristic, connected to the kinematical properties of ppppη at threshold, is used to extract the mass of the meson η. The obtained value, m η = 547.65 ± 0.18 MeV, is in good agreement with measurement done recently through the pd → H eη reaction. The total cross section σ t of ppppη measured at 1260, 1265 and 1300 MeV presents a strong energy dependence. This cross section increases less with energy than the phase-space. The influence of p-p and η-p final state interactions in our measurements is studied. Our results are compared with theoretical predictions and assess the dominant character of the baryonic resonance N * (1535) in the η mechanism production at threshold. These experimental results give an energy dependence which is not well reproduced by the theoretical predictions. This discrepancy could be an incorrect description of the η-p interaction in the models. (author). 48 refs., 60 figs., 15 tabs

  5. Endometrial protein PP14 and CA-125 in recurrent miscarriage patients; correlation with pregnancy outcome.

    Science.gov (United States)

    Dalton, C F; Laird, S M; Estdale, S E; Saravelos, H G; Li, T C

    1998-11-01

    The concentrations of endometrial proteins PP14 and CA-125 were measured in uterine flushings taken on days LH+10 and LH+12 (10 and 12 days after luteinizing hormone surge) of the menstrual cycle from 15 normal, fertile women and 49 women who suffered recurrent miscarriage. The concentration of PP14 was significantly lower in the flushings from the recurrent miscarriage patients than in those from fertile controls on both day LH+10 (median: 1300, range: 3-10 300 ng/ml versus median: 13 933, range: 2174-40 404 ng/ml; P < 0.01) and LH+12 (median: 1560, range: 820-12 100 ng/ml versus median: 14 047, range 1402-62 108 ng/ml; P < 0.05). Similarly concentrations of CA-125 were significantly lower in flushings from recurrent miscarriage women compared to controls on both day LH + 10 (median: 1555, range: 47-6710 U/ml versus median: 6385.5, range 2884-27 731 U/ml, P < 0.01) and LH+12 (median: 2892, range: 956-9974 U/ml versus median: 7127.5, range: 1591-21 343 U/ml; P < 0.05). In contrast there was no significant difference in the concentration of PP14 in plasma samples taken on the same days as the flushings from recurrent miscarriage patients and fertile controls. The concentrations of PP14 in uterine flushings obtained on day LH + 10 or LH + 12 from recurrent miscarriage women during a pre-pregnancy investigative cycle were significantly lower (P < 0.05) in patients who went on to miscarry (median: 1000, range: 9-2900 ng/ml) than those who went on to have a live birth (median: 1440, range: 4-12 100 ng/ml) during a subsequent pregnancy. In contrast there was no significant difference in uterine CA-125 or plasma PP14 concentrations between these two groups of recurrent miscarriage patients. The results suggest that measurements of uterine PP14 and CA-125 may be useful in the assessment of endometrial development in recurrent miscarriage patients and suggest the importance of PP14 in preparing the endometrium for embryo implantation. In addition pre-pregnancy uterine PP14

  6. Chiral power counting and ppppπ0 near threshold

    International Nuclear Information System (INIS)

    Van Kolck, U.; Miller, G.A.

    1995-01-01

    The ppppπ 0 reaction is studied near threshold using power counting arguments based on chiral perturbation theory with an explicit Δ degree of freedom. Important contributions include the so-called impulse term, rescattering via the Δ and rescattering via the (off-shell) seagull term responsible for s-wave pion-nucleon scattering. These contributions largely cancel so that their sum greatly underpredicts the total cross-section. Other mechanisms are also discussed. The inclusion of the previously proposed σ meson exchange mechanism is not sufficient to resolve the discrepancy with experiment

  7. Genome wide identification of wheat and Brachypodium type one protein phosphatases and functional characterization of durum wheat TdPP1a.

    Directory of Open Access Journals (Sweden)

    Mariem Bradai

    Full Text Available Reversible phosphorylation is an essential mechanism regulating signal transduction during development and environmental stress responses. An important number of dephosphorylation events in the cell are catalyzed by type one protein phosphatases (PP1, which catalytic activity is driven by the binding of regulatory proteins that control their substrate specificity or subcellular localization. Plants harbor several PP1 isoforms accounting for large functional redundancies. While animal PP1s were reported to play relevant roles in controlling multiple cellular processes, plant orthologs remain poorly studied. To decipher the role of plant PP1s, we compared PP1 genes from three monocot species, Brachypodium, common wheat and rice at the genomic and transcriptomic levels. To gain more insight into the wheat PP1 proteins, we identified and characterized TdPP1a, the first wheat type one protein phosphatase from a Tunisian durum wheat variety Oum Rabiaa3. TdPP1a is highly conserved in sequence and structure when compared to mammalian, yeast and other plant PP1s. We demonstrate that TdPP1a is an active, metallo-dependent phosphatase in vitro and is able to interact with AtI2, a typical regulator of PP1 functions. Also, TdPP1a is capable to complement the heat stress sensitivity of the yeast mutant indicating that TdPP1a is functional also in vivo. Moreover, transient expression of TdPP1a::GFP in tobacco leaves revealed that it is ubiquitously distributed within the cell, with a strong accumulation in the nucleus. Finally, transcriptional analyses showed similar expression levels in roots and leaves of durum wheat seedlings. Interestingly, the expression in leaves is significantly induced following salinity stress, suggesting a potential role of TdPP1a in wheat salt stress response.

  8. Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation.

    Science.gov (United States)

    Meyer-Roxlau, Stefanie; Lämmle, Simon; Opitz, Annett; Künzel, Stephan; Joos, Julius P; Neef, Stefan; Sekeres, Karolina; Sossalla, Samuel; Schöndube, Friedrich; Alexiou, Konstantin; Maier, Lars S; Dobrev, Dobromir; Guan, Kaomei; Weber, Silvio; El-Armouche, Ali

    2017-07-01

    Protein phosphatase 1 (PP1) is a key regulator of important cardiac signaling pathways. Dysregulation of PP1 has been heavily implicated in cardiac dysfunctions. Accordingly, pharmacological targeting of PP1 activity is considered for therapeutic intervention in human cardiomyopathies. Recent evidence from animal models implicated previously unrecognized, isoform-specific activities of PP1 in the healthy and diseased heart. Therefore, this study examined the expression of the distinct PP1 isoforms PP1α, β, and γ in human heart failure (HF) and atrial fibrillation (AF) and addressed the consequences of β-adrenoceptor blocker (beta-blocker) therapy for HF patients with reduced ejection fraction on PP1 isoform expression. Using western blot analysis, we found greater abundance of PP1 isoforms α and γ but unaltered PP1β levels in left ventricular myocardial tissues from HF patients as compared to non-failing controls. However, expression of all three PP1 isoforms was higher in atrial appendages from patients with AF compared to patients with sinus rhythm. Moreover, we found that in human failing ventricles, beta-blocker therapy was associated with lower PP1α abundance and activity, as indicated by higher phosphorylation of the PP1α-specific substrate eIF2α. Greater eIF2α phosphorylation is a known repressor of protein translation, and accordingly, we found lower levels of the endoplasmic reticulum (ER) stress marker Grp78 in the very same samples. We propose that isoform-specific targeting of PP1α activity may be a novel and innovative therapeutic strategy for the treatment of human cardiac diseases by reducing ER stress conditions.

  9. PP/clay nanocomposite films for food package; Filmes de nanocomposito PP/argila organofilica para embalagens de alimentos

    Energy Technology Data Exchange (ETDEWEB)

    Araujo, Arthur R.A.; Silva, Suedina M.L., E-mail: suedina@dema.ufcg.ed [Universidade Federal de Campina Grande (UAEMat/UFCG), PB (Brazil). Unidade Academica de Engenharia de Materiais; Andrade, Daniela L.A.C.S. [Universidade Federal de Campina Grande (UFCG), PB (Brazil). Programa de Pos-Graduacao em Engenharia de Processos; Mesquita, Wandemberg B [Felinto Industria e Comercio Ltda., Campina Grande, PB (Brazil)

    2009-07-01

    Small contents of organoclays (1 wt %) were incorporated to PP modified with maleic anhydride by melt intercalation, in order to prepare polymeric films for further applications in food package sector. The films were characterized by X-ray diffraction (XRD) and mechanical properties. The data indicates that the incorporation of organoclay to PP results in transparent films with intercalated morphology and highly. The mechanical properties of nanocomposites films were superior from those pristine films. The results evidences that the PP/PP-g-MA/organoclay nanocomposite films, prepared in this study might be promissory to the food package market and, in short time, be used like a new product by industries of this sector. (author)

  10. Pp scattering at SIN

    International Nuclear Information System (INIS)

    Aprile-Giboni, E.; Cantale, G.; Hausammann, R.

    1983-01-01

    Using the PM1 polarized proton beam at SIN and a polarized target, the elastic pp scattering as well as the inelastic channel pp → π + d have been studied between 400 and 600 MeV. For the elastic reaction, a sufficient number of spin dependent parameters has been measured in order to do a direct reconstruction of the scattering matrix between 38 0 /sub cm/ and 90 0 /sub cm/. 10 references, 6 figures

  11. Synemin promotes AKT-dependent glioblastoma cell proliferation by antagonizing PP2A.

    Science.gov (United States)

    Pitre, Aaron; Davis, Nathan; Paul, Madhumita; Orr, A Wayne; Skalli, Omar

    2012-04-01

    The intermediate filament protein synemin is present in astrocyte progenitors and glioblastoma cells but not in mature astrocytes. Here we demonstrate a role for synemin in enhancing glioblastoma cell proliferation and clonogenic survival, as synemin RNA interference decreased both behaviors by inducing G1 arrest along with Rb hypophosphorylation and increased protein levels of the G1/S inhibitors p21(Cip1) and p27(Kip1). Akt involvement was demonstrated by decreased phosphorylation of its substrate, p21(Cip1), and reduced Akt catalytic activity and phosphorylation at essential activation sites. Synemin silencing, however, did not affect the activities of PDPK1 and mTOR complex 2, which directly phosphorylate Akt activation sites, but instead enhanced the activity of the major regulator of Akt dephosphorylation, protein phosphatase type 2A (PP2A). This was accompanied by changes in PP2A subcellular distribution resulting in increased physical interactions between PP2A and Akt, as shown by proximity ligation assays (PLAs). PLAs and immunoprecipitation experiments further revealed that synemin and PP2A form a protein complex. In addition, treatment of synemin-silenced cells with the PP2A inhibitor cantharidic acid resulted in proliferation and pAkt and pRb levels similar to those of controls. Collectively these results indicate that synemin positively regulates glioblastoma cell proliferation by helping sequester PP2A away from Akt, thereby favoring Akt activation.

  12. ISAJET 5.30: A Monte Carlo event generator for pp and anti pp interactions

    International Nuclear Information System (INIS)

    Paige, F.E.; Protopopescu, S.D.

    1986-09-01

    ISAJET is a Monte Carlo program which simulates pp and anti pp interactions at high energy. It is based on perturbative QCD cross sections, leading order QCD radiative corrections for initial and final state partons, and phenomenological models for jet and beam jet fragmentation. This article describes ISAJET 5.30, which includes production of standard Higgs bosons and which will be released shortly

  13. The new ISR and collider anti p-p and p-p data and asymptotic theorems

    International Nuclear Information System (INIS)

    Nicolescu, B.

    1982-10-01

    We present a general discussion of the rigorous finite-energy effects of asymptotic theorems, with a special emphasis on the confrontation with the new ISR and collider antipp and pp total cross-section data. We point out the possible existence of a minimum in the difference between the antipp and pp total cross-sections

  14. Photooxidation of HMS-PP under environment and artificial weathering conditions

    International Nuclear Information System (INIS)

    Oliani, Washington L.; Parra, Duclerc F.; Lima, Luis Filipe C.P.; Lugao, Ademar B.

    2009-01-01

    The linearity of the chains confers to iPP, low melt strength, which means a low strength to stretching during elongation. The increase of melt strength and the extensibility is due to the increase of the entanglement of the macromolecules chains. The HMS-PP (high melt strength polypropylene) was synthesized (based on the grains iPP) through gamma irradiation in the iPP under acetylene atmosphere followed by heat treatment for recombination and subsequent annihilation of the other free radicals. Samples of HMS-PP and iPP were subjected to environmental aging in IPEN - Sao Paulo and in the QUV chamber. The results show fractured surfaces of iPP and HMS-PP that are intensified with exposure time. The iPP degradation process has the predominance of chain scissions, with carbonyl and hydroperoxides formation which act as initiators of photo degradation mechanisms. (author)

  15. Study of pp sup(-) → X+π- and pp sup(-) → X0#betta# reactions

    International Nuclear Information System (INIS)

    Alves, M.S.; Thome Filho, Z.D.

    1982-01-01

    Detailed calculations of the cross section of the pp sup(-) → X + π - and pp sup(-) → X 0 #betta# reactions, with the inclusion of the p meson exchange in the first reaction, are made. In the second one, the cross section is obtained taking into account the contribution of the simpler diagrams. (L.C.) [pt

  16. Core Drilling of shallow drillholes OL-PP72...OL-PP89 at Olkiluoto, Eurajoki 2011

    Energy Technology Data Exchange (ETDEWEB)

    Toropainen, V. [Suomen Malmi Oy, Espoo (Finland)

    2012-05-15

    Suomen Malmi Oy (Smoy) core drilled eighteen drillholes to survey the ground and bedrock conditions in the encapsulation plant building site at Olkiluoto, Eurajoki 2011. Soil quality, bedrock depth and quality of near surface bedrock were investigated in this project. The drillholes were drilled between 19th of October and 8th of November 2011. The lengths of the drillholes are mostly between 7 to 9 metres, except for the drillhole OL-PP79, which is 15 metres by length. The drillholes are 76 mm by diameter, and the core diameter is 60.2 mm. The lightweight GM75 drilling rig with rubber tracks was used. The drilling water was taken from the ONKALO area research building freshwater pipeline and sodium fluorescein was added as a label agent in the drilling water. The drillholes were not left open. In addition to drilling the drillcores were logged and reported by geologist. Geological logging included the following parameters: lithology, foliation, fracture parameters, fractured zones, core loss, weathering, fracture frequency, RQD and rock quality. The average natural fracture frequencies of the drillcores range from 2.5 pc/m (OL-PP77) to 11.8 pc/m (OL-PP86). The average RQD ranges from 55.1 % (OL-PP86) to 96.4 % (OL-PP77). The penetrated soils are mostly ground fill (blast rock), but some clays and sands are lying below the fill layer. (orig.)

  17. Core Drilling of shallow drillholes OL-PP72...OL-PP89 at Olkiluoto, Eurajoki 2011

    International Nuclear Information System (INIS)

    Toropainen, V.

    2012-05-01

    Suomen Malmi Oy (Smoy) core drilled eighteen drillholes to survey the ground and bedrock conditions in the encapsulation plant building site at Olkiluoto, Eurajoki 2011. Soil quality, bedrock depth and quality of near surface bedrock were investigated in this project. The drillholes were drilled between 19th of October and 8th of November 2011. The lengths of the drillholes are mostly between 7 to 9 metres, except for the drillhole OL-PP79, which is 15 metres by length. The drillholes are 76 mm by diameter, and the core diameter is 60.2 mm. The lightweight GM75 drilling rig with rubber tracks was used. The drilling water was taken from the ONKALO area research building freshwater pipeline and sodium fluorescein was added as a label agent in the drilling water. The drillholes were not left open. In addition to drilling the drillcores were logged and reported by geologist. Geological logging included the following parameters: lithology, foliation, fracture parameters, fractured zones, core loss, weathering, fracture frequency, RQD and rock quality. The average natural fracture frequencies of the drillcores range from 2.5 pc/m (OL-PP77) to 11.8 pc/m (OL-PP86). The average RQD ranges from 55.1 % (OL-PP86) to 96.4 % (OL-PP77). The penetrated soils are mostly ground fill (blast rock), but some clays and sands are lying below the fill layer. (orig.)

  18. Differential cross sections of the pp -> pp pi sup 0 reaction from 310 to 425 MeV

    CERN Document Server

    Zlomanczuk, Yu; Brodowski, W; Calén, H; Clement, H; Dyring, J; Ekström, C; Fäldt, G; Fransson, K; Gustafsson, L; Häggström, S; Hoeistad, B; Johanson, J; Johansson, A; Johansson, T; Kilian, K; Kullander, Sven; Kupsc, A; Marciniewski, P; Morosov, B; Moertsell, A; Oelert, W; Ruber, Roger J M Y; Schuberth, U; Sundberg, P; Shwartz, B A; Stepaniak, J; Sukhanov, A; Turowiecki, A; Wagner, G J; Wilhelmi, Z; Wilkin, C; Zabierowski, J; Zernov, A

    2000-01-01

    Measurements of the differential cross sections of the pp -> pp pi sup 0 reaction at 310, 320, 340, 360, 400 and 425 MeV have been carried out at the CELSIUS storage ring in Uppsala. An attempt has been made to describe the distributions obtained in terms of the five partial waves Ss, Ps, Pp, Sd and Ds. The relative contributions from the different states depend significantly upon the energy. For instance, that of the Ss state drops from about 80% at 310 MeV to around 10% at 425 MeV.

  19. PP/clay nanocomposite films for food package

    International Nuclear Information System (INIS)

    Araujo, Arthur R.A.; Silva, Suedina M.L.

    2009-01-01

    Small contents of organoclays (1 wt %) were incorporated to PP modified with maleic anhydride by melt intercalation, in order to prepare polymeric films for further applications in food package sector. The films were characterized by X-ray diffraction (XRD) and mechanical properties. The data indicates that the incorporation of organoclay to PP results in transparent films with intercalated morphology and highly. The mechanical properties of nanocomposites films were superior from those pristine films. The results evidences that the PP/PP-g-MA/organoclay nanocomposite films, prepared in this study might be promissory to the food package market and, in short time, be used like a new product by industries of this sector. (author)

  20. Relationship between compatibilizer and yield strength of PLA/PP Blend

    Science.gov (United States)

    Jariyakulsith, Pattanun; Puajindanetr, Somchai

    2018-01-01

    The aim of this research is to study the relationship between compatibilizer and yield strength of polylactic acid (PLA) and polypropylene (PP) blend. The PLA is blended with PP (PLA/PP) at the ratios of 70/30, 50/50 and 30/70. In addition, (1) polypropylene grafted maleic anhydride (PP-g-MAH) as a compatibilizer at 0.3 and 0.7 part per hundred of PLA/PP resin (phr) and (2) dicumyl peroxide (DCP) being an initiator at 0.03 and 0.07 phr are added in each composition. Yield strength is characterized to study the interaction between compatibilizer, initiator and yield strength by using experimental design of multilevel full factorial. The results show that (1) the yield strength of PLA/PP blend are increased after addition of compatibilizer. Because the adding of PP-g-MAH and DCP resulted in improving compatibility between PLA and PP. (2) there are interaction between PP-g-MAH and DCP that have affected the final properties of PLA/PP blend. The highest yield strength of 27.68 MPa is provided at the ratio of 70/30 blend by using the 0.3 phr of PP-g-MAH and 0.03 phr of DCP. Linear regression model is fitted and follow the assumptions of normal distribution.

  1. Physiological and Pathological Roles of CaMKII-PP1 Signaling in the Brain

    Directory of Open Access Journals (Sweden)

    Norifumi Shioda

    2017-12-01

    Full Text Available Ca2+/calmodulin (CaM-dependent protein kinase II (CaMKII, a multifunctional serine (Ser/threonine (Thr protein kinase, regulates diverse activities related to Ca2+-mediated neuronal plasticity in the brain, including synaptic activity and gene expression. Among its regulators, protein phosphatase-1 (PP1, a Ser/Thr phosphatase, appears to be critical in controlling CaMKII-dependent neuronal signaling. In postsynaptic densities (PSDs, CaMKII is required for hippocampal long-term potentiation (LTP, a cellular process correlated with learning and memory. In response to Ca2+ elevation during hippocampal LTP induction, CaMKIIα, an isoform that translocates from the cytosol to PSDs, is activated through autophosphorylation at Thr286, generating autonomous kinase activity and a prolonged Ca2+/CaM-bound state. Moreover, PP1 inhibition enhances Thr286 autophosphorylation of CaMKIIα during LTP induction. By contrast, CaMKII nuclear import is regulated by Ser332 phosphorylation state. CaMKIIδ3, a nuclear isoform, is dephosphorylated at Ser332 by PP1, promoting its nuclear translocation, where it regulates transcription. In this review, we summarize physio-pathological roles of CaMKII/PP1 signaling in neurons. CaMKII and PP1 crosstalk and regulation of gene expression is important for neuronal plasticity as well as survival and/or differentiation.

  2. (p)ppGpp and the bacterial cell cycle

    Indian Academy of Sciences (India)

    Genes of the Rel/Spo homolog (RSH) superfamily synthesize and/or hydrolyse the modified nucleotides pppGpp/ppGpp (collectively referred to as (p)ppGpp) and are prevalent across diverse bacteria and in plant chloroplasts. Bacteria accumulate (p)ppGpp in response to nutrient deprivation (generically called the stringent ...

  3. Effects of composition and processing conditions on morphology and properties of thermoplastic elastomer blends of SEBS-PP-Oil and dynamically vulcanized EPDM-PP-Oil

    NARCIS (Netherlands)

    Sengupta, P.; Noordermeer, Jacobus W.M.

    2004-01-01

    This work presents a comparative study of the morphology and structure-related properties of thermoplastic elastomer blends based on SEBS-PP-oil and dynamically vulcanized EPDM-PP-oil prepared under identical conditions. Compositions of each blend type with three different SEBS-PP and EPDM-PP ratios

  4. Displacement affinity chromatography of protein phosphatase one (PP1 complexes

    Directory of Open Access Journals (Sweden)

    Gourlay Robert

    2008-11-01

    Full Text Available Abstract Background Protein phosphatase one (PP1 is a ubiquitously expressed, highly conserved protein phosphatase that dephosphorylates target protein serine and threonine residues. PP1 is localized to its site of action by interacting with targeting or regulatory proteins, a majority of which contains a primary docking site referred to as the RVXF/W motif. Results We demonstrate that a peptide based on the RVXF/W motif can effectively displace PP1 bound proteins from PP1 retained on the phosphatase affinity matrix microcystin-Sepharose. Subsequent co-immunoprecipitation experiments confirmed that each identified binding protein was either a direct PP1 interactor or was in a complex that contains PP1. Our results have linked PP1 to numerous new nuclear functions and proteins, including Ki-67, Rif-1, topoisomerase IIα, several nuclear helicases, NUP153 and the TRRAP complex. Conclusion This modification of the microcystin-Sepharose technique offers an effective means of purifying novel PP1 regulatory subunits and associated proteins and provides a simple method to uncover a link between PP1 and additional cellular processes.

  5. Studies on the properties of rice-husk-filled-PP composites: effect of maleated PP

    Directory of Open Access Journals (Sweden)

    Simone Maria Leal Rosa

    2009-09-01

    Full Text Available Rice husk is a by-product of rice milling process that usually finds inadequate final disposal (burning, land filling. Thermoplastics composites filled with rice husk flour are materials that offer an alternative for using this agricultural resource viewing the production of low dense materials with some specific properties. In this work composites of polypropylene (PP and rice husk flour (RHF were prepared by melt extrusion. Maleic anhydride-modified PP (MAPP was added as a coupling agent. It was verified that tensile strength decreased with filler loading. The presence of MAPP improved this property showing a strong dependence on the MAPP/RHF ratio (MAPP/RHF = 0.03 produced the best results. The density of the composites slightly increased with filler and coupling agent in comparison to pure PP. The presence of MAPP diminished more than 20% water uptake in highly-loaded composites.

  6. Electron Spin Resonance studies on PS, PP and PS/PP blends under gamma irradiation

    International Nuclear Information System (INIS)

    Reyes, J.; Claro, M.; Albano, C.; Venezuela Central University, Caracas; Moronta, D.

    2002-01-01

    Complete text of publication follows. Electron Spin Resonance (ESR) studies on Polystyrene (PS), Polypropylene (PP) and their mixtures at compositions of 80/20 with and without a compatibilizer (SBS in block), 7.5 wt.%, irradiated with gamma rays from a Cobalt-60 source with a dose rate of 4.8 KGy/h at integral doses of radiation of 10, 25, 50, 60, 70, 400, 800 and 1300 KGy in the presence of air and at room temperature (RT) are reported. The dependence of resonance line width, Hpp; resonance line shapes K, and radical concentration, S, with the integral dose of irradiation is investigated. The nature of the free radicals after ten days of air storage is discussed. The free radical concentration, the double integral of the resonance line, S, has been estimated at room temperature, RT, for a group of single lines, characterized by the same giromagnetic, g, value by direct numerical double integration. In the samples studied no spectrum of 0 kGy of integral dose was observed. The concentration of radicals, S, observed when the integral radiation doses was increased, presents a maximum value in the PP samples at high doses (70-1300 kGy) and minimum values in the PS samples with the same doses. This shows that the PP degrades at a faster rate than the PS, owing to the presence of the bencenic ring in the latter. In the PS/PP mixtures studied with and without compatibilizer, the values of the radical concentration is found between the observed values in the homopolymers, being closer to the PS, which might imply that the presence of PS decays the degradation process of the PP in the mixture

  7. Study on GIF PR/PP evaluation methodology

    Energy Technology Data Exchange (ETDEWEB)

    Lee, B. H.; Kwon, E. H.; Kim, H. D. [KAERI, Daejeon (Korea, Republic of)

    2012-10-15

    Proliferation resistance (PR) and physical protection (PP) is one of the four technology goals of generation IV nuclear energy systems (NESs). The PR component of the goal focuses on providing strong assurance that generation IV NESs are the least desirable sources for the diversion or undeclared production of nuclear materials, whereas the PP portion of the goal ensures that generation IV NESs are robust against theft and sabotage. In 2002, the road map of the Generation IV International Forum (GIF) envisioned that the R and D program for PR and PP would have three areas: 1) safeguards and physical protection technology R and D for each GIF system; 2) formulation of PR and PP criteria and metrics; and 3) evaluation of the criteria and metrics. To cover these R and D items, the PR and PP Working Group (PRPPWG) was formed in late 2002 and has since developed a methodology for PR and PP evaluation. In a succession of revisions beginning in 2004, consensus was achieved amongst all participating GIF countries and related organizations (i.e., IAEA and EU), and Revision 6 of the methodology report was approved by GIF for open distribution in 2011. The paper describes in detail the methodology developed by the PRPPWG and discusses its applicability to the sodium-cooled fast reactor (SFR) fuel cycle with pyro processing currently under development in Korea.

  8. Pion interferometry and resonances in pp and AA collisions

    Energy Technology Data Exchange (ETDEWEB)

    Padula, S.S. (UNESP, Inst. de Fisica Teorica, Sao Paulo (Brazil)); Gyulassy, M. (Lawrence Berkeley Lab., Nuclear Science Div., CA (United States))

    1992-07-20

    We study the sensitivity of pion interferometry in pp and anti pp collisions at ISR energies to the resonance abundance. We show that those data are not compatible with the full resonance fractions predicted by the Lund model. The preliminary S+S and O+Au data at 200 A GeV are, however, not incompatible with the Lund predictions, although their sensitivity to resonances is significantly weaker than in the pp/anti pp case. (orig.).

  9. Pion interferometry and resonances in pp and AA collisions

    International Nuclear Information System (INIS)

    Padula, S.S.; Gyulassy, M.

    1992-01-01

    We study the sensitivity of pion interferometry in pp and anti pp collisions at ISR energies to the resonance abundance. We show that those data are not compatible with the full resonance fractions predicted by the Lund model. The preliminary S+S and O+Au data at 200 A GeV are, however, not incompatible with the Lund predictions, although their sensitivity to resonances is significantly weaker than in the pp/anti pp case. (orig.)

  10. Pion interferometry and resonances in pp and AA collisions

    International Nuclear Information System (INIS)

    Padula, S.S.

    1991-01-01

    We study the sensitivity of pion interferometry in bar pp and bar pp collisions at ISR energies to the resonance abundance. We show that those data are not compatible with the full resonance fractions predicted by the Lund model. The preliminary S+S and O+Au data at 200 GeV are, however, not incompatible with the Lund predictions, although their sensitivity to resonances is significantly weaker than in the pp/bar pp case

  11. Effect of mouse antisera targeting the Phlebotomus papatasi midgut chitinase PpChit1 on sandfly physiology and fitness

    Directory of Open Access Journals (Sweden)

    Maricela Robles-Murguia

    2014-12-01

    Full Text Available In sandflies, the absence of the peritrophic matrix (PM affects the rate of blood digestion. Also, the kinetics of PM secretion varies according to species. We previously characterised PpChit1, a midgut-specific chitinase secreted in Phlebotomus papatasi (PPIS that is involved in the maturation of the PM and showed that antibodies against PpChit1 reduce the chitinolytic activity in the midgut of several sandfly species. Here, sandflies were fed on red blood cells reconstituted with naïve or anti-PpChit1 sera and assessed for fitness parameters that included blood digestion, oviposition onset, number of eggs laid, egg bouts, average number of eggs per bout and survival. In PPIS, anti-PpChit1 led to a one-day delay in the onset of egg laying, with flies surviving three days longer compared to the control group. Anti-PpChit1 also had a negative effect on overall ability of flies to lay eggs, as several gravid females from all three species were unable to lay any eggs despite having lived longer than control flies. Whereas the longer survival might be associated with improved haeme scavenging ability by the PM, the inability of females to lay eggs is possibly linked to changes in PM permeability affecting nutrient absorption.

  12. Effects of thermal ageing on HMS-PP crystallinity

    International Nuclear Information System (INIS)

    Oliani, Washington L.; Parra, Duclerc F.; Lima, Luis F.C.P.; Lugao, Ademar B.

    2009-01-01

    The isotactic polypropylene is a linear polymer which exhibits low melt strength. Irradiation of PP under inert atmosphere causes a combination of chain scissioning and long-chain branching, and results in a material with significant enhanced melt strength. This process, which is sometimes termed visbreaking, thus provides improvement of rheological properties. HMS-PP (High Melt Strength Polypropylene) was obtained by the irradiation in atmosphere of acetylene as crosslinker agent. It was employed doses of 12.5 and 20 kGy of gamma radiation. The objective of this study is to investigate the effects of thermal ageing on the crystallinity level and chemical structure of HMS-PP. The thermal stability of the HMS-PP was evaluated after thermal ageing of samples using a stove at temperature of 90 deg C, in presence of air at different periods of time. The samples submitted to the thermal ageing were characterized by: thermogravimetry (TGA), differential scanning calorimetry (DSC), infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). Since the long-term engineering properties of HMS-PP are intrinsically linked with the polymer microstructure, there is significant interest in understanding the effects of ageing, particularly due to prolonged exposure at service temperatures. In thermo-oxidative conditions, the formation of the oxidation products essentially involves a hydrogen abstraction by the peroxyl radicals, leading to hydroperoxides as primary products and chemical degradation in the immediate crack tips. Oxidative degradation on the network of HMS-PP, created by radiation process of PP, was revealed by the analytical results showing the susceptibility of HMS-PP to thermal oxidative degradation. Yellowing of the samples surface and oxidative products of degradation among other evidences were observed. (author)

  13. Tensile and impact properties of three-component PP/wood/elastomer composites

    Directory of Open Access Journals (Sweden)

    B. Pukanszky

    2012-03-01

    Full Text Available Polypropylene (PP was reinforced with wood flour and impact modified with elastomers to increase stiffness and impact resistance simultaneously. Elastomer content changed in four (0, 5, 10 and 20 wt%, while that of wood content in seven steps, the latter from 0 to 60 wt% in 10 wt% steps. Structure and adhesion were controlled by the addition of functionalized (maleated polymers. Composites were homogenized in a twin-screw extruder and then injection molded to tensile bars. Fracture resistance was characterized by standard and instrumented impact tests. The results showed that the components are dispersed independently of each other even when a functionalized elastomer is used for impact modification, at least under the conditions of this study. Impact resistance does not change much as a function of wood content in PP/wood composites, but decreases drastically from the very high level of the PP/elastomer blend to almost the same value obtained without impact modifier in the three-component materials. Increasing stiffness and fiber related local deformation processes led to small fracture toughness at large wood content. Micromechanical deformation processes depend mainly on the strength of PP/wood interaction; debonding and pull-out take place at poor adhesion, while fiber fracture dominates when adhesion is strong. Composites with sufficiently large impact resistance cannot be prepared in the usual range of wood contents (50–60 wt%.

  14. Genome wide identification of wheat and Brachypodium type one protein phosphatases and functional characterization of durum wheat TdPP1a

    OpenAIRE

    Bradai, Mariem; Mahjoubi, Habib; Chini, Andrea; Chabouté, Marie-Edith; Hanin, Moez; Ebel, Chantal

    2018-01-01

    Reversible phosphorylation is an essential mechanism regulating signal transduction during development and environmental stress responses. An important number of dephosphorylation events in the cell are catalyzed by type one protein phosphatases (PP1), which catalytic activity is driven by the binding of regulatory proteins that control their substrate specificity or subcellular localization. Plants harbor several PP1 isoforms accounting for large functional redundancies. While animal PP1s we...

  15. Is PT -symmetric quantum theory false as a fundamental theory?

    Czech Academy of Sciences Publication Activity Database

    Znojil, Miloslav

    2016-01-01

    Roč. 56, č. 3 (2016), s. 254-257 ISSN 1210-2709 R&D Projects: GA ČR GA16-22945S Institutional support: RVO:61389005 Keywords : quantum mechanics * PT-symmetric representations of observables * masurement outcomes Subject RIV: BE - Theoretical Physics

  16. Abaca fibre reinforced PP composites and comparison with jute and flax fibre PP composites

    Directory of Open Access Journals (Sweden)

    2007-11-01

    Full Text Available Abaca fibre reinforced PP composites were fabricated with different fibre loadings (20, 30, 40, 50wt% and in some cases 35 and 45 wt%. Flax and jute fibre reinforced PP composites were also fabricated with 30 wt% fibre loading. The mechanical properties, odour emission and structure properties were investigated for those composites. Tensile, flexural and Charpy impact strengths were found to increase for fibre loadings up to 40 wt% and then decreased. Falling weight impact tests were also carried out and the same tendency was observed. Owing to the addition of coupling agent (maleated polypropylene -MAH-PP, the tensile, flexural and falling weight impact properties were found to increase in between 30 to 80% for different fibre loadings. When comparing jute and flax fibre composites with abaca fibre composites, jute fibre composites provided best tensile properties but abaca fibre polypropylene composites were shown to provide best notch Charpy and falling weight impact properties. Odours released by flax fibre composites were smaller than jute and abaca fibre composites.

  17. Personalized Therapy Against Preeclampsia by Replenishing Placental Protein 13 (PP13 Targeted to Patients With Impaired PP13 Molecule or Function

    Directory of Open Access Journals (Sweden)

    Hamutal Meiri

    Full Text Available Hypertensive disorders affect about one third of all people aged 20 and above, and are treated with anti-hypertensive drugs. Preeclampsia (PE is one form of such disorders that only develops during pregnancy. It affects ten million pregnant women globally and additionally causes fetal loss and major newborn disabilities. The syndrome's origin is multifactorial, and anti-hypertensive drugs are ineffective in treating it. Biomarkers are helpful for predict its development. Generic drugs, such as low dose aspirin, were proven effective in preventing preterm PE. However, it does not cure the majority of cases and many studies are underway for fighting PE with extended use of additional generic drugs, or through new drug development programs.This review focuses on placental protein 13 (PP13. This protein is only expressed in the placenta. Impaired PP13 DNA structure and/or its reduced mRNA expression leads to lower blood PP13 level that predict a higher risk of developing PE. Two polymorphic PP13 variants have been identified: (1 The promoter PP13 variant with an “A/A” genotype in the -98 position (versus “A/C” or “C/C”. Having the “A/A” genotype is coupled to lower PP13 expression, mainly during placental syncytiotrophoblast differentiation and, if associated with obesity and history of previous preeclampsia, it accurately predicts higher risk for developing the disorder. (2 A thymidine deletion at position 221 causes a frame shift in the open reading frame, and the formation of an early stop codon resulting in the formation of DelT221, a truncated variant of PP13. In pregnant rodents, both short- and long- term replenishment of PP13 causes reversible hypotension and vasodilation of uterine vessels. Long-term exposure is also accompanied by the development of larger placentas and newborns. Also, only w/t PP13 is capable of inducing leukocyte apoptosis, providing maternal immune tolerance to pregnancy.Based on published data, we

  18. Multiplicity correlations in the forward and backward hemispheres in the center of mass in bar pp and pp interactions at 32 GeV/c

    International Nuclear Information System (INIS)

    Bravina, L.V.; Amelin, N.S.; Bogolyubskii, M.Y.; Bumazhnov, V.A.; Vinitskii, A.A.; Ermolov, P.F.; Zhautykov, B.O.; Zabrodin, E.E.; Kiryunin, A.E.; Klochkov, M.A.; Kotova, A.I.; Kruglov, N.A.; Levitskii, M.S.; Lukina, O.Y.; Minaenko, A.A.; Moiseev, A.M.; Murzin, V.S.; Proskuryakov, A.S.; Rizatdinova, F.K.; Sarycheva, L.I.; Smirnova, L.N.; Starchenko, E.A.; Ukhanov, M.N.; Chekulaev, S.V.

    1989-01-01

    A rise in the average multiplicity of particles in one hemisphere in the c.m.s. of bar pp and pp interactions with energy (s) 1/2 =7.86 GeV is observed with increase of the number of particles in the other hemisphere. The correlation parameter reaches b=0.19±0.01 and 0.10±0.02 in inelastic bar pp and pp interactions respectively. The observed correlations are reproduced in the quark-gluon string model

  19. Exclusive channels in bar pp annihilation at rest

    International Nuclear Information System (INIS)

    Bluem, P.

    1992-01-01

    Exclusive channels in bar pp annihilation at rest provide a powerful tool for studying the meson spectrum below the bar pp threshold. The mesons can be classified in SU(3) multiplets according to their quantum numbers. The states which do not fit into this classification are candidates for new forms of hadronic matter like glueballs, hybrids, and multi-quark states. Recent results on the search for exotic states in exclusive channels of bar pp annihilation at rest are discussed. No less important is the study of the annihilation mechanism. In particular, high-statistic measurements of bar pp annihilation at rest into two-meson final states are an excellent tool for studying quark dynamics. Examples of two-body reactions are presented. 24 refs., 9 figs., 3 tabs

  20. Texturing of polypropylene (PP) with nanosecond lasers

    Science.gov (United States)

    Riveiro, A.; Soto, R.; del Val, J.; Comesaña, R.; Boutinguiza, M.; Quintero, F.; Lusquiños, F.; Pou, J.

    2016-06-01

    Polypropylene (PP) is a biocompatible and biostable polymer, showing good mechanical properties that has been recently introduced in the biomedical field for bone repairing applications; however, its poor surface properties due to its low surface energy limit their use in biomedical applications. In this work, we have studied the topographical modification of polypropylene (PP) laser textured with Nd:YVO4 nanosecond lasers emitting at λ = 1064 nm, 532 nm, and 355 nm. First, optical response of this material under these laser wavelengths was determined. The application of an absorbing coating was also studied. The influence of the laser processing parameters on the surface modification of PP was investigated by means of statistically designed experiments. Processing maps to tailor the roughness, and wettability, the main parameters affecting cell adhesion characteristics of implants, were also determined. Microhardness measurements were performed to discern the impact of laser treatment on the final mechanical properties of PP.

  1. Core drilling of hydco drillholes ONK-PP262 and ONK-PP274 in ONKALO at Olkiluoto 2010

    Energy Technology Data Exchange (ETDEWEB)

    Toropainen, V. [Suomen Malmi Oy, Espoo (Finland)

    2011-10-15

    Suomen Malmi Oy (Smoy) core drilled two drillholes for HYDCO-program in ONKALO at Eurajoki, Olkiluoto in 2010. The drillhole ONK-PP262 was drilled in May 2010 and the drillhole ONK-PP274 in December 2010. The lengths of the drillholes are 25.02 and 23.88 m respectively. The drillholes are 75.7 mm by diameter. The drillholes were drilled in the investigation niche 4 at the access tunnel chainage 3747. The hydraulic DE 130 drilling rig was used. The drilling water was taken from the ONKALO drilling water pipeline and premixed sodium fluorescein was used as a label agent in the drilling water. The drillholes were measured with EMS deviation survey tool. In addition to drilling the drillcores were logged and reported by geologist. Geological logging included the following parameters: lithology, foliation, fracture parameters, fractured zones, core loss, weathering, fracture frequency, RQD and rock quality. The main rock types in the drillholes are veined gneiss and pegmatitic granite. The average fracture frequencies in both drill cores are 1.4 pcs/m. The average RQD values in the drillcores are 97.2 % (ONK-PP262) and 98.6 % (ONK-PP274). (orig.)

  2. Core drilling of hydco drillholes ONK-PP262 and ONK-PP274 in ONKALO at Olkiluoto 2010

    International Nuclear Information System (INIS)

    Toropainen, V.

    2011-10-01

    Suomen Malmi Oy (Smoy) core drilled two drillholes for HYDCO-program in ONKALO at Eurajoki, Olkiluoto in 2010. The drillhole ONK-PP262 was drilled in May 2010 and the drillhole ONK-PP274 in December 2010. The lengths of the drillholes are 25.02 and 23.88 m respectively. The drillholes are 75.7 mm by diameter. The drillholes were drilled in the investigation niche 4 at the access tunnel chainage 3747. The hydraulic DE 130 drilling rig was used. The drilling water was taken from the ONKALO drilling water pipeline and premixed sodium fluorescein was used as a label agent in the drilling water. The drillholes were measured with EMS deviation survey tool. In addition to drilling the drillcores were logged and reported by geologist. Geological logging included the following parameters: lithology, foliation, fracture parameters, fractured zones, core loss, weathering, fracture frequency, RQD and rock quality. The main rock types in the drillholes are veined gneiss and pegmatitic granite. The average fracture frequencies in both drill cores are 1.4 pcs/m. The average RQD values in the drillcores are 97.2 % (ONK-PP262) and 98.6 % (ONK-PP274). (orig.)

  3. The Lectin Domain of the Polypeptide GalNAc Transferase Family of Glycosyltransferases (ppGalNAc Ts) Acts as a Switch Directing Glycopeptide Substrate Glycosylation in an N- or C-terminal Direction, Further Controlling Mucin Type O-Glycosylation

    DEFF Research Database (Denmark)

    Gerken, Thomas A; Revoredo, Leslie; Thome, Joseph J C

    2013-01-01

    and specificity that differ between transferase isoforms. For example, ppGalNAc T1, T2, and T14 prefer C-terminally placed GalNAc-O-Thr, whereas ppGalNAc T3 and T6 prefer N-terminally placed GalNAc-O-Thr. Several transferase isoforms, ppGalNAc T5, T13, and T16, display equally enhanced N- or C-terminal activities...... relative to the nonglycosylated control peptides. This N- and/or C-terminal selectivity is presumably due to weak glycopeptide binding to the lectin domain, whose orientation relative to the catalytic domain is dynamic and isoform-dependent. Such N- or C-terminal glycopeptide selectivity provides...

  4. Evidence for CP violation in B+ → ppK+ decays.

    Science.gov (United States)

    Aaij, R; Adeva, B; Adinolfi, M; Affolder, A; Ajaltouni, Z; Akar, S; Albrecht, J; Alessio, F; Alexander, M; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves, A A; Amato, S; Amerio, S; Amhis, Y; An, L; Anderlini, L; Anderson, J; Andreassen, R; Andreotti, M; Andrews, J E; Appleby, R B; Aquines Gutierrez, O; Archilli, F; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Baalouch, M; Bachmann, S; Back, J J; Badalov, A; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Batozskaya, V; Battista, V; Bay, A; Beaucourt, L; Beddow, J; Bedeschi, F; Bediaga, I; Belogurov, S; Belous, K; Belyaev, I; Ben-Haim, E; Bencivenni, G; Benson, S; Benton, J; Berezhnoy, A; Bernet, R; Bettler, M-O; van Beuzekom, M; Bien, A; Bifani, S; Bird, T; Bizzeti, A; Bjørnstad, P M; Blake, T; Blanc, F; Blouw, J; Blusk, S; Bocci, V; Bondar, A; Bondar, N; Bonivento, W; Borghi, S; Borgia, A; Borsato, M; Bowcock, T J V; Bowen, E; Bozzi, C; Brambach, T; van den Brand, J; Bressieux, J; Brett, D; Britsch, M; Britton, T; 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Grabalosa Gándara, M; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graziani, G; Grecu, A; Greening, E; Gregson, S; Griffith, P; Grillo, L; Grünberg, O; Gui, B; Gushchin, E; Guz, Yu; Gys, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hall, S; Hamilton, B; Hampson, T; Han, X; Hansmann-Menzemer, S; Harnew, N; Harnew, S T; Harrison, J; He, J; Head, T; Heijne, V; Hennessy, K; Henrard, P; Henry, L; Hernando Morata, J A; van Herwijnen, E; Heß, M; Hicheur, A; Hill, D; Hoballah, M; Hombach, C; Hulsbergen, W; Hunt, P; Hussain, N; Hutchcroft, D; Hynds, D; Idzik, M; Ilten, P; Jacobsson, R; Jaeger, A; Jalocha, J; Jans, E; Jaton, P; Jawahery, A; Jing, F; John, M; Johnson, D; Jones, C R; Joram, C; Jost, B; Jurik, N; Kaballo, M; Kandybei, S; Kanso, W; Karacson, M; Karbach, T M; Karodia, S; Kelsey, M; Kenyon, I R; Ketel, T; Khanji, B; Khurewathanakul, C; Klaver, S; Klimaszewski, K; Kochebina, O; Kolpin, M; Komarov, I; Koopman, R F; Koppenburg, P; Korolev, M; Kozlinskiy, A; Kravchuk, L; Kreplin, K; Kreps, M; Krocker, G; Krokovny, P; Kruse, F; Kucewicz, W; Kucharczyk, M; Kudryavtsev, V; Kurek, K; Kvaratskheliya, T; La Thi, V N; Lacarrere, D; Lafferty, G; Lai, A; Lambert, D; Lambert, R W; Lanfranchi, G; Langenbruch, C; Langhans, B; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Lees, J-P; Lefèvre, R; Leflat, A; Lefrançois, J; Leo, S; Leroy, O; Lesiak, T; Leverington, B; Li, Y; Likhomanenko, T; Liles, M; Lindner, R; Linn, C; Lionetto, F; Liu, B; Lohn, S; Longstaff, I; Lopes, J H; Lopez-March, N; Lowdon, P; Lu, H; Lucchesi, D; Luo, H; Lupato, A; Luppi, E; Lupton, O; Machefert, F; Machikhiliyan, I V; Maciuc, F; Maev, O; Malde, S; Malinin, A; Manca, G; Mancinelli, G; Maratas, J; Marchand, J F; Marconi, U; Marin Benito, C; Marino, P; Märki, R; Marks, J; Martellotti, G; Martens, A; Martín Sánchez, A; Martinelli, M; Martinez Santos, D; Martinez Vidal, F; Martins Tostes, D; Massafferri, A; Matev, R; Mathe, Z; Matteuzzi, C; Mazurov, A; McCann, M; McCarthy, J; McNab, A; McNulty, R; McSkelly, B; Meadows, B; Meier, F; Meissner, M; Merk, M; Milanes, D A; Minard, M-N; Moggi, N; Molina Rodriguez, J; Monteil, S; Morandin, M; Morawski, P; Mordà, A; Morello, M J; Moron, J; Morris, A-B; Mountain, R; Muheim, F; Müller, K; Mussini, M; Muster, B; Naik, P; Nakada, T; Nandakumar, R; Nasteva, I; Needham, M; Neri, N; Neubert, S; Neufeld, N; Neuner, M; Nguyen, A D; Nguyen, T D; Nguyen-Mau, C; Nicol, M; Niess, V; Niet, R; Nikitin, N; Nikodem, T; Novoselov, A; O'Hanlon, D P; Oblakowska-Mucha, A; Obraztsov, V; Oggero, S; Ogilvy, S; Okhrimenko, O; Oldeman, R; Onderwater, G; Orlandea, M; Otalora Goicochea, J M; Owen, P; Oyanguren, A; Pal, B K; Palano, A; Palombo, F; Palutan, M; Panman, J; Papanestis, A; Pappagallo, M; Pappalardo, L L; Parkes, C; Parkinson, C J; Passaleva, G; Patel, G D; Patel, M; Patrignani, C; Pazos Alvarez, A; Pearce, A; Pellegrino, A; Pepe Altarelli, M; Perazzini, S; Perez Trigo, E; Perret, P; Perrin-Terrin, M; Pescatore, L; Pesen, E; Petridis, K; Petrolini, A; Picatoste Olloqui, E; Pietrzyk, B; Pilař, T; Pinci, D; Pistone, A; Playfer, S; Plo Casasus, M; Polci, F; Poluektov, A; Polycarpo, E; Popov, A; Popov, D; Popovici, B; Potterat, C; Price, E; Prisciandaro, J; Pritchard, A; Prouve, C; Pugatch, V; Puig Navarro, A; Punzi, G; Qian, W; Rachwal, B; Rademacker, J H; Rakotomiaramanana, B; Rama, M; Rangel, M S; Raniuk, I; Rauschmayr, N; Raven, G; Reichert, S; Reid, M M; Dos Reis, A C; Ricciardi, S; Richards, S; Rihl, M; Rinnert, K; Rives Molina, V; Roa Romero, D A; Robbe, P; Rodrigues, A B; Rodrigues, E; Rodriguez Perez, P; Roiser, S; Romanovsky, V; Romero Vidal, A; Rotondo, M; Rouvinet, J; Ruf, T; Ruffini, F; Ruiz, H; Ruiz Valls, P; Saborido Silva, J J; Sagidova, N; Sail, P; Saitta, B; Salustino Guimaraes, V; Sanchez Mayordomo, C; Sanmartin Sedes, B; Santacesaria, R; Santamarina Rios, C; Santovetti, E; Sarti, A; Satriano, C; Satta, A; Saunders, D M; Savrie, M; Savrina, D; Schiller, M; Schindler, H; Schlupp, M; Schmelling, M; Schmidt, B; Schneider, O; Schopper, A; Schune, M-H; Schwemmer, R; Sciascia, B; Sciubba, A; Seco, M; Semennikov, A; Sepp, I; Serra, N; Serrano, J; Sestini, L; Seyfert, P; Shapkin, M; Shapoval, I; Shcheglov, Y; Shears, T; Shekhtman, L; Shevchenko, V; Shires, A; Silva Coutinho, R; Simi, G; Sirendi, M; Skidmore, N; Skwarnicki, T; Smith, N A; Smith, E; Smith, E; Smith, J; Smith, M; Snoek, H; Sokoloff, M D; Soler, F J P; Soomro, F; Souza, D; Souza De Paula, B; Spaan, B; Sparkes, A; Spradlin, P; Sridharan, S; Stagni, F; Stahl, M; Stahl, S; Steinkamp, O; Stenyakin, O; Stevenson, S; Stoica, S; Stone, S; Storaci, B; Stracka, S; Straticiuc, M; Straumann, U; Stroili, R; Subbiah, V K; Sun, L; Sutcliffe, W; Swientek, K; Swientek, S; Syropoulos, V; Szczekowski, M; Szczypka, P; Szilard, D; Szumlak, T; T'Jampens, S; Teklishyn, M; Tellarini, G; Teubert, F; Thomas, C; Thomas, E; van Tilburg, J; Tisserand, V; Tobin, M; Tolk, S; Tomassetti, L; Tonelli, D; Topp-Joergensen, S; Torr, N; Tournefier, E; Tourneur, S; Tran, M T; Tresch, M; Tsaregorodtsev, A; Tsopelas, P; Tuning, N; Ubeda Garcia, M; Ukleja, A; Ustyuzhanin, A; Uwer, U; Vagnoni, V; Valenti, G; Vallier, A; Vazquez Gomez, R; Vazquez Regueiro, P; Vázquez Sierra, C; Vecchi, S; Velthuis, J J; Veltri, M; Veneziano, G; Vesterinen, M; Viaud, B; Vieira, D; Vieites Diaz, M; Vilasis-Cardona, X; Vollhardt, A; Volyanskyy, D; Voong, D; Vorobyev, A; Vorobyev, V; Voß, C; Voss, H; de Vries, J A; Waldi, R; Wallace, C; Wallace, R; Walsh, J; Wandernoth, S; Wang, J; Ward, D R; Watson, N K; Websdale, D; Whitehead, M; Wicht, J; Wiedner, D; Wilkinson, G; Williams, M P; Williams, M; Wilson, F F; Wimberley, J; Wishahi, J; Wislicki, W; Witek, M; Wormser, G; Wotton, S A; Wright, S; Wu, S; Wyllie, K; Xie, Y; Xing, Z; Xu, Z; Yang, Z; Yuan, X; Yushchenko, O; Zangoli, M; Zavertyaev, M; Zhang, L; Zhang, W C; Zhang, Y; Zhelezov, A; Zhokhov, A; Zhong, L; Zvyagin, A

    2014-10-03

    Three-body B+ → ppK+ and B(+) → ppπ(+) decays are studied using a data sample corresponding to an integrated luminosity of 3.0 fb(-1) collected by the LHCb experiment in proton-proton collisions at center-of-mass energies of 7 and 8 TeV. Evidence of CP violation in the B(+) → ppK(+) decay is found in regions of the phase space, representing the first measurement of this kind for a final state containing baryons. Measurements of the forward-backward asymmetry of the light meson in the pp rest frame yield A(FB)(ppK(+),m(pp)m(pp) <2.85 GeV/c(2)) = -0.409 ± 0.033 (stat) ± 0.006 (syst). In addition, the branching fraction of the decay B(+) → Λ(1520)p is measured to be B(B(+) → Λ(1520)p) = (3.15 ± 0.48 (stat) ± 0.07 (syst) ± 0.26 (BF)) × 10(-7), where BF denotes the uncertainty on secondary branching fractions.

  5. Invariant-mass distributions for the pp{yields}pp{eta} reaction at Q=10 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Moskal, P.; Czerwinski, E.; Klaja, J.; Klaja, P.; Krzemien, W. [Jagellonian University, Institute of Physics, Cracow (Poland); Research Center Juelich, Nuclear Physics Institute, Juelich (Germany); Czyzykiewicz, R. [Jagellonian University, Institute of Physics, Cracow (Poland); University of Silesia, Institute of Physics, Katowice (Poland); Gil, D.; Jarczyk, L.; Kamys, B.; Silarski, M.; Smyrski, J.; Zdebik, J.; Zielinski, M.J. [Jagellonian University, Institute of Physics, Cracow (Poland); Grzonka, D.; Oelert, W.; Ritman, J.; Sefzick, T.; Wuestner, P. [Research Center Juelich, Nuclear Physics Institute, Juelich (Germany); Khoukaz, A.; Taeschner, A.; Zipper, W. [Westfaelische Wilhelms-Universitaet, IKP, Muenster (Germany); Siemaszko, M. [University of Silesia, Institute of Physics, Katowice (Poland); Wolke, M. [SE-751 05 Uppsala University, Department of Physics and Astronomy, Uppsala (Sweden)

    2010-02-15

    Proton-proton and proton-{eta} invariant-mass distributions and the total cross-section for the pp{yields}pp{eta} reaction have been determined near the threshold at an excess energy of Q=10 MeV. The experiment has been conducted using the COSY-11 detector setup and the cooler synchrotron COSY. The determined invariant-mass spectra reveal significant enhancements in the region of low proton-proton relative momenta, similarly as observed previously at higher excess energies of Q=15.5 MeV and Q=40 MeV. (orig.)

  6. Verwendung von Polypropylen/Polyglactin 910- (PP910- und Polypropylen/Polyglecapron 25 (PP25- Netzen bei Beckenbodenprolaps - eine retrospektive Analyse

    Directory of Open Access Journals (Sweden)

    Schwegler Ch

    2009-01-01

    Full Text Available Die Entwicklung von Polypropylen- Implantaten zur Behandlung von Bauchwandhernien stellt einen Meilenstein in der Geschichte der Chirurgie dar. Mit einigen Jahren Verzug folgten die Urogynäkologen den Chirurgen und begannen, Polypropylen-Netze zur Behebung von Beckenbodenvorfällen einzusetzen. PP910-Netze (Vypro II®, Ethicon und PP25-Netze (Ultrapro®, Ethicon werden seit Langem mit gutem Erfolg bei Hernien-Operationen eingesetzt. Das Ziel dieser Studie war herauszufinden, inwieweit sich diese beiden Netze auch für den Einsatz beim Beckenbodenprolaps eignen. Hierzu wurden Fragebögen an Patientinnen versandt, denen in den Jahren 2003 und 2004 diese Netze im Beckenboden implantiert wurden. Die Hauptfragestellungen waren hierbei, inwiefern sich die Symptome des Vorfalles nach der Behandlung verändert hatten und welche Komplikationen nach der Operation aufgetreten waren. Beide Gruppen zeigten nach dem Netzeinsatz deutliche Verbesserungen der Symptomatik bei einer geringen Komplikationsquote. Beim Einsatz von PP910 zeigten sich in 6 % der Fälle Komplikationen, die auf die Implantation des Netzes zurückgeführt werden konnten. Beim Einsatz von PP25 zeigten sogar nur 1,5 % der operierten Frauen netzbedingte Komplikationen. Somit hat sich gezeigt, dass beide Netze gut für die Verwendung im Beckenboden geeignet sind. Vergleicht man die beiden Netze mit anderen Produkten, die derzeit als Implantate im Beckenboden genutzt werden, so zeigt sich ein sehr positives Ergebnis mit signifikant weniger postoperativen Komplikationen unter der Verwendung von PP25-Netzen. Im Rahmen dieser Analyse konnte festgestellt werden, dass PP25 ein sehr sicheres Netz mit ausgesprochen guten Ergebnissen für die Therapie des Beckenbodenprolaps ist.

  7. Search for narrow pp states in the reaction pi /sup -/p to p pi /sup - /pp at 16 GeV/c

    CERN Document Server

    Chung, S U; Bensinger, J; Button-Shafer, J; Dhar, S; Dowd, J; Etkin, A; Fernow, R; Foley, K; Goldman, J H; Kern, W; Kirk, H; Kopp, J; Kramer, M A; Lesnik, A; Lichti, R; Lindenbaum, S J; Love, W; Mallik, U; Morris, T; Morris, W; Ozaki, S; Platner, E; Protopopescu, S D; Saulys, A; Weygand, D P; Wheeler, C D; Willen, E; Winik, M

    1980-01-01

    This Letter carries out a sensitive ( approximately 5 events/nb) search for narrow pp states at the Brookhaven National Laboratory multiparticle spectrometer. No evidence is found for such states in the mass range 1900-2400 MeV/c/sup 2/ in the reaction pi /sup -/p to p pi /sup -/pp at 16 GeV/c. In particular, the pp states at 2020 and 2200 MeV/c/sup 2/ previously reported in a CERN Omega -spectrometer experiment are not observed. (7 refs).

  8. Stability and assembly in vitro of bacteriophage PP7 virus-like particles

    Directory of Open Access Journals (Sweden)

    Peabody David S

    2007-11-01

    Full Text Available Abstract Background The stability of a virus-like particle (VLP is an important consideration for its use in nanobiotechnology. The icosahedral capsid of the RNA bacteriophage PP7 is cross-linked by disulfide bonds between coat protein dimers at its 5-fold and quasi-6-fold symmetry axes. This work determined the effects of these disulfides on the VLP's thermal stability. Results Measurements of the thermal denaturation behavior of PP7 VLPs in the presence and absence of a reducing agent show that disulfide cross-links substantially stabilize them against thermal denaturation. Although dimers in the capsid are linked to one another by disulfides, the two subunits of dimers themselves are held together only by non-covalent interactions. In an effort to confer even greater stability a new cross-link was introduced by genetically fusing two coat protein monomers, thus producing a "single-chain dimer" that assembles normally into a completely cross-linked VLP. However, subunit fusion failed to increase the thermal stability of the particles, even though it stabilized the isolated dimer. As a step toward gaining control of the internal composition of the capsid, conditions that promote the assembly of PP7 coat protein dimers into virus-like particles in vitro were established. Conclusion The presence of inter-dimer disulfide bonds greatly stabilizes the PP7 virus-like particle against thermal denaturation. Covalently cross-linking the subunits of the dimers themselves by genetically fusing them through a dipeptide linker sequence, offers no further stabilization of the VLP, although it does stabilize the dimer. PP7 capsids readily assemble in vitro in a reaction that requires RNA.

  9. PP13, maternal ABO blood groups and the risk assessment of pregnancy complications.

    Directory of Open Access Journals (Sweden)

    Nandor Gabor Than

    Full Text Available Placental Protein 13 (PP13, an early biomarker of preeclampsia, is a placenta-specific galectin that binds beta-galactosides, building-blocks of ABO blood-group antigens, possibly affecting its bioavailability in blood.We studied PP13-binding to erythrocytes, maternal blood-group effect on serum PP13 and its performance as a predictor of preeclampsia and intrauterine growth restriction (IUGR. Datasets of maternal serum PP13 in Caucasian (n = 1078 and Hispanic (n = 242 women were analyzed according to blood groups. In vivo, in vitro and in silico PP13-binding to ABO blood-group antigens and erythrocytes were studied by PP13-immunostainings of placental tissue-microarrays, flow-cytometry of erythrocyte-bound PP13, and model-building of PP13--blood-group H antigen complex, respectively. Women with blood group AB had the lowest serum PP13 in the first trimester, while those with blood group B had the highest PP13 throughout pregnancy. In accordance, PP13-binding was the strongest to blood-group AB erythrocytes and weakest to blood-group B erythrocytes. PP13-staining of maternal and fetal erythrocytes was revealed, and a plausible molecular model of PP13 complexed with blood-group H antigen was built. Adjustment of PP13 MoMs to maternal ABO blood group improved the prediction accuracy of first trimester maternal serum PP13 MoMs for preeclampsia and IUGR.ABO blood group can alter PP13-bioavailability in blood, and it may also be a key determinant for other lectins' bioavailability in the circulation. The adjustment of PP13 MoMs to ABO blood group improves the predictive accuracy of this test.

  10. PP2A regulates kinetochore-microtubule attachment during meiosis I in oocyte.

    Science.gov (United States)

    Tang, An; Shi, Peiliang; Song, Anying; Zou, Dayuan; Zhou, Yue; Gu, Pengyu; Huang, Zan; Wang, Qinghua; Lin, Zhaoyu; Gao, Xiang

    2016-06-02

    Studies using in vitro cultured oocytes have indicated that the protein phosphatase 2A (PP2A), a major serine/threonine protein phosphatase, participates in multiple steps of meiosis. Details of oocyte maturation regulation by PP2A remain unclear and an in vivo model can provide more convincing information. Here, we inactivated PP2A by mutating genes encoding for its catalytic subunits (PP2Acs) in mouse oocytes. We found that eliminating both PP2Acs caused female infertility. Oocytes lacking PP2Acs failed to complete 1(st) meiotic division due to chromosome misalignment and abnormal spindle assembly. In mitosis, PP2A counteracts Aurora kinase B/C (AurkB/C) to facilitate correct kinetochore-microtubule (KT-MT) attachment. In meiosis I in oocyte, we found that PP2Ac deficiency destabilized KT-MT attachments. Chemical inhibition of AurkB/C in PP2Ac-null oocytes partly restored the formation of lateral/merotelic KT-MT attachments but not correct KT-MT attachments. Taken together, our findings demonstrate that PP2Acs are essential for chromosome alignments and regulate the formation of correct KT-MT attachments in meiosis I in oocytes.

  11. Comparison of forward and backward pp pair knockout in 3He(e,e'pp)n

    Science.gov (United States)

    Baghdasaryan, H.; Weinstein, L. B.; Laget, J. M.; Adhikari, K. P.; Aghasyan, M.; Amaryan, M. J.; Anghinolfi, M.; Ball, J.; Battaglieri, M.; Biselli, A. S.; Briscoe, W. J.; Brooks, W. K.; Burkert, V. D.; Carman, D. S.; Celentano, A.; Chandavar, S.; Charles, G.; Cole, P. L.; Contalbrigo, M.; Crede, V.; D'Angelo, A.; Daniel, A.; Dashyan, N.; De Sanctis, E.; De Vita, R.; Djalali, C.; Dodge, G. E.; Doughty, D.; Dupre, R.; Egiyan, H.; El Alaoui, A.; El Fassi, L.; Elouadrhiri, L.; Fedotov, G.; Gabrielyan, M. Y.; Gevorgyan, N.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Gohn, W.; Gothe, R. W.; Griffioen, K. A.; Guegan, B.; Guidal, M.; Hafidi, K.; Hicks, K.; Hyde, C. E.; Ireland, D. G.; Ishkhanov, B. S.; Jenkins, D.; Jo, H. S.; Joo, K.; Khandaker, M.; Khetarpal, P.; Kim, A.; Kim, W.; Kubarovsky, A.; Kubarovsky, V.; Kuhn, S. E.; Kuleshov, S. V.; Kvaltine, N. D.; Lu, H. Y.; MacGregor, I. J. D.; McKinnon, B.; Mirazita, M.; Mokeev, V.; Moutarde, H.; Munevar, E.; Niccolai, S.; Niculescu, G.; Niculescu, I.; Osipenko, M.; Paolone, M.; Pappalardo, L. L.; Paremuzyan, R.; Park, K.; Park, S.; Pisano, S.; Pozdniakov, S.; Procureur, S.; Raue, B. A.; Ricco, G.; Rimal, D.; Ripani, M.; Rosner, G.; Rossi, P.; Saini, M. S.; Saylor, N. A.; Schott, D.; Schumacher, R. A.; Seraydaryan, H.; Smith, E. S.; Sober, D. I.; Sokan, D.; Stepanyan, S. S.; Stepanyan, S.; Strauch, S.; Taiuti, M.; Tang, W.; Tkachenko, S.; Voskanyan, H.; Voutier, E.; Wood, M. H.; Zana, L.; Zhao, B.

    2012-06-01

    Measuring nucleon-nucleon short range correlations (SRCs) has been a goal of the nuclear physics community for many years. They are an important part of the nuclear wave function, accounting for almost all of the high-momentum strength. They are closely related to the EMC effect. While their overall probability has been measured, measuring their momentum distributions is more difficult. In order to determine the best configuration for studying SRC momentum distributions, we measured the 3He(e,e'pp)n reaction, looking at events with high-momentum protons (pp>0.35 GeV/c) and a low-momentum neutron (pn<0.2 GeV/c). We examined two angular configurations: either both protons emitted forward or one proton emitted forward and one backward (with respect to the momentum transfer, q⃗). The measured relative momentum distribution of the events with one forward and one backward proton was much closer to the calculated initial-state pp relative momentum distribution, indicating that this is the preferred configuration for measuring SRC.

  12. A method of constructive quantum mechanics of remarkable hidden beauty

    Czech Academy of Sciences Publication Activity Database

    Znojil, Miloslav

    2016-01-01

    Roč. 49, č. 45 (2016), č. článku 451003. ISSN 1751-8113 R&D Projects: GA ČR GA16-22945S Institutional support: RVO:61389005 Keywords : eigenvalue problems * iteration method Subject RIV: BE - Theoretical Physics Impact factor: 1.857, year: 2016

  13. PP13, Maternal ABO Blood Groups and the Risk Assessment of Pregnancy Complications

    Science.gov (United States)

    Than, Nandor Gabor; Romero, Roberto; Meiri, Hamutal; Erez, Offer; Xu, Yi; Tarquini, Federica; Barna, Laszlo; Szilagyi, Andras; Ackerman, Ron; Sammar, Marei; Fule, Tibor; Karaszi, Katalin; Kovalszky, Ilona; Dong, Zhong; Kim, Chong Jai; Zavodszky, Peter; Papp, Zoltan; Gonen, Ron

    2011-01-01

    Background Placental Protein 13 (PP13), an early biomarker of preeclampsia, is a placenta-specific galectin that binds beta-galactosides, building-blocks of ABO blood-group antigens, possibly affecting its bioavailability in blood. Methods and Findings We studied PP13-binding to erythrocytes, maternal blood-group effect on serum PP13 and its performance as a predictor of preeclampsia and intrauterine growth restriction (IUGR). Datasets of maternal serum PP13 in Caucasian (n = 1078) and Hispanic (n = 242) women were analyzed according to blood groups. In vivo, in vitro and in silico PP13-binding to ABO blood-group antigens and erythrocytes were studied by PP13-immunostainings of placental tissue-microarrays, flow-cytometry of erythrocyte-bound PP13, and model-building of PP13 - blood-group H antigen complex, respectively. Women with blood group AB had the lowest serum PP13 in the first trimester, while those with blood group B had the highest PP13 throughout pregnancy. In accordance, PP13-binding was the strongest to blood-group AB erythrocytes and weakest to blood-group B erythrocytes. PP13-staining of maternal and fetal erythrocytes was revealed, and a plausible molecular model of PP13 complexed with blood-group H antigen was built. Adjustment of PP13 MoMs to maternal ABO blood group improved the prediction accuracy of first trimester maternal serum PP13 MoMs for preeclampsia and IUGR. Conclusions ABO blood group can alter PP13-bioavailability in blood, and it may also be a key determinant for other lectins' bioavailability in the circulation. The adjustment of PP13 MoMs to ABO blood group improves the predictive accuracy of this test. PMID:21799738

  14. A detailed study of $(n_{ch}) vs E^{had}$ and $m_{1,2}$ at different $\\sqrt{s}_{pp}$ in (pp) interactions

    CERN Document Server

    Basile, M; Cesare, P D; Cifarelli, L; Contin, A; Curatolo, M; D'Ali, G; Esposito, B; Giusti, P; Massam, Thomas; Nania, R; Palmonari, F; Petrosino, A; Romeo, G C; Rossi, V; Sartorelli, G; Spinetti, M; Susinno, G; Valenti, G; Votano, L; Zichichi, A

    1982-01-01

    By using (pp) interactions at three different CM energies, ( \\sqrt{s})/sub pp/=30, 44, 62 GeV, it is shown that the average charged- particle multiplicity (n/sub ch/) vs. the invariant mass of the hadronic system m/sub 1,2/ has the same behaviour as it has vs. 2E/sup had/. Moreover, in both cases (n/sub ch/) is shown to be nearly independent of ( \\sqrt{s})/sub pp/ and in good agreement with the average charged-particle multiplicity measured in the (e^{+}e/sup - /) annihilation.

  15. ppGpp Controls Global Gene Expression in Light and in Darkness in S. elongatus

    Directory of Open Access Journals (Sweden)

    Anna M. Puszynska

    2017-12-01

    Full Text Available The bacterial and plant stringent response involves production of the signaling molecules guanosine tetraphosphate and guanosine pentaphosphate ((pppGpp, leading to global reorganization of gene expression. The function of the stringent response has been well characterized in stress conditions, but its regulatory role during unstressed growth is less studied. Here, we demonstrate that (pppGpp-deficient strains of S. elongatus have globally deregulated biosynthetic capacity, with increased transcription rate, translation rate, and cell size in unstressed conditions in light and impaired viability in darkness. Synthetic restoration of basal guanosine tetraphosphate (ppGpp levels is sufficient to recover transcriptional balance and appropriate cell size in light and to rescue viability in light/dark conditions, but it is insufficient to enable efficient dark-induced transcriptional shutdown. Our work underscores the importance of basal ppGpp signaling for regulation of cyanobacterial physiology in the absence of stress and for viability in energy-limiting conditions, highlighting that basal (pppGpp level is essential in cyanobacteria in the environmental light/dark cycle.

  16. Study of PP/Polybutene Blends Modified by Gamma Irradiation and HMS-PP/Polybutene Blends

    International Nuclear Information System (INIS)

    Lugao, A. B.

    2006-01-01

    The polypropylene (PP) has been applied to a wide range of production due to its various excellent properties such as cheapness, high stiffness, chemical resistance, no environmental pollution when incinerated, low specific density and good mechanical properties. However, PP is a linear polymer which exhibits low melt strength. One of the effective approaches to achieve high melt strength (HMS) is to add chain branches onto backbone polymers. High melt strength polypropylene (HMS-PP) has been recently developed and introduced in the market by the major international polypropylene producers. As a consequence different methods have been applied to modify polypropylenes by chain branches. The technology obtained by IPEN together with EMBRARAD and BRASKEM comprises chain branches added onto backbone species using gamma radiation, which is generated from a Co 6 0 source. Such radiation is very convenient in order to improve polymer materials by grafting, crosslinking and degradation. Another important approach to the development of polymer materials is based on the combination of different polymers into a new product having some of the desired properties of each component. In this work, gamma irradiation technique was used to induce chemical changes in commercial polypropylene (HMS-PP) that was after blended with polybutene and in polypropylene/polybutene blends. The samples were irradiated with a 60 C o source at doses of 12,5 and 20kGy in the presence of acetylene. It was investigated how the two different routes of blends processing can modify their properties. Indeed the results from melt flow, gel fraction and rheology reveal the influence of the process route in the blends properties. Effects on the elongation at break and break strength were observed by the results of mechanical tests. The results from rheology demonstrated an increase in melt strength and drawability of the blends

  17. Characteristics of the groups of charged particles in bar pp,pp and K-p interactions at 32 GeV/c

    International Nuclear Information System (INIS)

    Bogolubsky, M.Yu.; Levitsky, M.S.; Maksimov, V.V.

    1995-01-01

    In the clan model, a method is developed for determining the following characteristics of the groups of charged particles: group multiplicity in an interval, particle multiplicity in a group, and width distribution of groups. Distribution densities are obtained for particles originating from clans produced at a given rapidity point with given width in bar pp, K - p, and pp interactions at 32 GeV/c. It is shown that the differences in the rate of growth of factorial moments in bar pp and K - p interactions are due to a difference in the relative contributions of small-width clans. 12 refs., 13 figs., 2 tabs

  18. Adaptation of HepG2 cells to a steady-state reduction in the content of protein phosphatase 6 (PP6) catalytic subunit

    Energy Technology Data Exchange (ETDEWEB)

    Boylan, Joan M. [Department of Pediatrics, Brown University and Rhode Island Hospital, Providence, RI (United States); Salomon, Arthur R. [Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI (United States); Department of Chemistry, Brown University, Providence, RI (United States); Tantravahi, Umadevi [Division of Genetics, Department of Pathology, Brown University and Women and Infants Hospital, Providence, RI (United States); Gruppuso, Philip A., E-mail: philip_gruppuso@brown.edu [Department of Pediatrics, Brown University and Rhode Island Hospital, Providence, RI (United States); Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI (United States)

    2015-07-15

    Protein phosphatase 6 (PP6) is a ubiquitous Ser/Thr phosphatase involved in an array of cellular processes. To assess the potential of PP6 as a therapeutic target in liver disorders, we attenuated expression of the PP6 catalytic subunit in HepG2 cells using lentiviral-transduced shRNA. Two PP6 knock-down (PP6KD) cell lines (90% reduction of PP6-C protein content) were studied in depth. Both proliferated at a rate similar to control cells. However, flow cytometry indicated G2/M cell cycle arrest that was accounted for by a shift of the cells from a diploid to tetraploid state. PP6KD cells did not show an increase in apoptosis, nor did they exhibit reduced viability in the presence of bleomycin or taxol. Gene expression analysis by microarray showed attenuated anti-inflammatory signaling. Genes associated with DNA replication were downregulated. Mass spectrometry-based phosphoproteomic analysis yielded 80 phosphopeptides representing 56 proteins that were significantly affected by a stable reduction in PP6-C. Proteins involved in DNA replication, DNA damage repair and pre-mRNA splicing were overrepresented among these. PP6KD cells showed intact mTOR signaling. Our studies demonstrated involvement of PP6 in a diverse set of biological pathways and an adaptive response that may limit the effectiveness of targeting PP6 in liver disorders. - Highlights: • Lentiviral-transduced shRNA was used to generate a stable knockdown of PP6 in HepG2 cells. • Cells adapted to reduced PP6; cell proliferation was unaffected, and cell survival was normal. • However, PP6 knockdown was associated with a transition to a tetraploid state. • Genomic profiling showed downregulated anti-inflammatory signaling and DNA replication. • Phosphoproteomic profiling showed changes in proteins associated with DNA replication and repair.

  19. Adaptation of HepG2 cells to a steady-state reduction in the content of protein phosphatase 6 (PP6) catalytic subunit

    International Nuclear Information System (INIS)

    Boylan, Joan M.; Salomon, Arthur R.; Tantravahi, Umadevi; Gruppuso, Philip A.

    2015-01-01

    Protein phosphatase 6 (PP6) is a ubiquitous Ser/Thr phosphatase involved in an array of cellular processes. To assess the potential of PP6 as a therapeutic target in liver disorders, we attenuated expression of the PP6 catalytic subunit in HepG2 cells using lentiviral-transduced shRNA. Two PP6 knock-down (PP6KD) cell lines (90% reduction of PP6-C protein content) were studied in depth. Both proliferated at a rate similar to control cells. However, flow cytometry indicated G2/M cell cycle arrest that was accounted for by a shift of the cells from a diploid to tetraploid state. PP6KD cells did not show an increase in apoptosis, nor did they exhibit reduced viability in the presence of bleomycin or taxol. Gene expression analysis by microarray showed attenuated anti-inflammatory signaling. Genes associated with DNA replication were downregulated. Mass spectrometry-based phosphoproteomic analysis yielded 80 phosphopeptides representing 56 proteins that were significantly affected by a stable reduction in PP6-C. Proteins involved in DNA replication, DNA damage repair and pre-mRNA splicing were overrepresented among these. PP6KD cells showed intact mTOR signaling. Our studies demonstrated involvement of PP6 in a diverse set of biological pathways and an adaptive response that may limit the effectiveness of targeting PP6 in liver disorders. - Highlights: • Lentiviral-transduced shRNA was used to generate a stable knockdown of PP6 in HepG2 cells. • Cells adapted to reduced PP6; cell proliferation was unaffected, and cell survival was normal. • However, PP6 knockdown was associated with a transition to a tetraploid state. • Genomic profiling showed downregulated anti-inflammatory signaling and DNA replication. • Phosphoproteomic profiling showed changes in proteins associated with DNA replication and repair

  20. Low energy bar pp physics

    International Nuclear Information System (INIS)

    Amsler, C.; Crowe, K.

    1989-02-01

    A detailed investigation of proton-antiproton interactions at low energy has become feasible with the commissioning of the LEAR facility in 1983. We shall shortly review the status of bar pp annihilation at rest and the physics motivations for second generation experiments with the Crystal Barrel detector. This type of detector would be adequate for the study of both Kp and bar pp interactions on an extracted beam of the KAON Factory. We shall conclude with a few remarks on the physics opportunities with bar p's at the KAON Factory which, in our opinion, will not be covered by the present LEAR facility. 11 refs., 10 figs., 2 tabs

  1. Characterisation and expression of a PP1 serine/threonine protein phosphatase (PfPP1 from the malaria parasite, Plasmodium falciparum: demonstration of its essential role using RNA interference

    Directory of Open Access Journals (Sweden)

    Musiyenko Alla

    2002-04-01

    Full Text Available Abstract Background Reversible protein phosphorylation is relatively unexplored in the intracellular protozoa of the Apicomplexa family that includes the genus Plasmodium, to which belong the causative agents of malaria. Members of the PP1 family represent the most highly conserved protein phosphatase sequences in phylogeny and play essential regulatory roles in various cellular pathways. Previous evidence suggested a PP1-like activity in Plasmodium falciparum, not yet identified at the molecular level. Results We have identified a PP1 catalytic subunit from P. falciparum and named it PfPP1. The predicted primary structure of the 304-amino acid long protein was highly similar to PP1 sequences of other species, and showed conservation of all the signature motifs. The purified recombinant protein exhibited potent phosphatase activity in vitro. Its sensitivity to specific phosphatase inhibitors was characteristic of the PP1 class. The authenticity of the PfPP1 cDNA was further confirmed by mutational analysis of strategic amino acid residues important in catalysis. The protein was expressed in all erythrocytic stages of the parasite. Abrogation of PP1 expression by synthetic short interfering RNA (siRNA led to inhibition of parasite DNA synthesis. Conclusions The high sequence similarity of PfPP1 with other PP1 members suggests conservation of function. Phenotypic gene knockdown studies using siRNA confirmed its essential role in the parasite. Detailed studies of PfPP1 and its regulation may unravel the role of reversible protein phosphorylation in the signalling pathways of the parasite, including glucose metabolism and parasitic cell division. The use of siRNA could be an important tool in the functional analysis of Apicomplexan genes.

  2. Observation of rapidity gaps in bar pp collisions at 1.8 TeV

    International Nuclear Information System (INIS)

    Abe, F.; Albrow, M.; Amidei, D.; Anway-Wiese, C.; Apollinari, G.; Atac, M.; Auchincloss, P.; Azzi, P.; Bacchetta, N.; Baden, A.R.; Badgett, W.; Bailey, M.W.; Bamberger, A.; de Barbaro, P.; Barbaro-Galtieri, A.; Barnes, V.E.; Barnett, B.A.; Bartalini, P.; Bauer, G.; Baumann, T.; Bedeschi, F.; Behrends, S.; Belforte, S.; Bellettini, G.; Bellinger, J.; Benjamin, D.; Benlloch, J.; Bensinger, J.; Beretvas, A.; Berge, J.P.; Bertolucci, S.; Biery, K.; Bhadra, S.; Binkley, M.; Bisello, D.; Blair, R.; Blocker, C.; Bodek, A.; Bolognesi, V.; Booth, A.W.; Boswell, C.; Brandenburg, G.; Brown, D.; Buckley-Geer, E.; Budd, H.S.; Busetto, G.; Byon-Wagner, A.; Byrum, K.L.; Campagnari, C.; Campbell, M.; Caner, A.; Carey, R.; Carithers, W.; Carlsmith, D.; Carroll, J.T.; Cashmore, R.; Castro, A.; Cen, Y.; Cervelli, F.; Chadwick, K.; Chapman, J.; Chiarelli, G.; Chinowsky, W.; Cihangir, S.; Clark, A.G.; Cobal, M.; Connor, D.; Contreras, M.; Cooper, J.; Cordelli, M.; Crane, D.; Cunningham, J.D.; Day, C.; DeJongh, F.; Dell'Agnello, S.; Dell'Orso, M.; Demortier, L.; Denby, B.; Derwent, P.F.; Devlin, T.; Dickson, M.; Donati, S.; Drucker, R.B.; Dunn, A.; Einsweiler, K.; Elias, J.E.; Ely, R.; Eno, S.; Errede, S.; Etchegoyen, A.; Farhat, B.; Feldman, G.J.; Flaugher, B.; Foster, G.W.; Franklin, M.; Frautschi, M.; Freeman, J.; Frisch, H.; Fuess, T.; Fukui, Y.; Gagliardi, G.; Garfinkel, A.F.; Gauthier, A.; Geer, S.; Gerdes, D.W.; Giannetti, P.; Giokaris, N.; Gladney, L.; Gold, M.; Gonzalez, J.; Goshaw, A.; Goulianos, K.; Grassmann, H.; Grieco, G.M.; Grindley, R.; Grosso-Pilcher, C.; Haber, C.; Hahn, S.R.; Handler, R.; Hara, K.; Harral, B.; Harris, R.M.; Hauger, S.A.; Hauser, J.; Hawk, C.; Hessing, T.; Hollebeek, R.; Holloway, L.; Hoelscher, A.; Hong, S.; Houk, G.; Hu, P.; Hubbard, B.; Huffman, B.T.; Hughes, R.; Hurst, P.; Huth, J.; Hylen, J.; Incagli, M.; Ino, T.; Iso, H.; Jensen, H.; Jessop, C.P.; Johnson, R.P.; Joshi, U.; Kadel, R.W.; Kamon, T.; Kanda, S.; Kardelis, D.A.; Karliner, I.

    1995-01-01

    In pp bar pp collisions at √s=1.8TeV we find jet events with a rapidity gap topology. The number of hadrons in the rapidity interval Δη D between leading-jet cones was sampled by charged tracks with P T >400MeV/c. We find excess trackless events beyond that expected in a smooth multiplicity distribution. In a control region outside Δη D we see no excess. For Δη D >0.8, the fraction of excess trackless events, consistent with estimates based on exchange of color-singlet digluons, is R(gap)=σ jet (gap)/σ jet = 0.0085±0.0012(stat) -0.0012 +0.0024 (syst)

  3. Comparative proteomic analysis of Salmonella enterica serovar Typhimurium ppGpp-deficient mutant to identify a novel virulence protein required for intracellular survival in macrophages

    Directory of Open Access Journals (Sweden)

    Kumagai Yoshinori

    2010-12-01

    Full Text Available Abstract Background The global ppGpp-mediated stringent response in pathogenic bacteria plays an important role in the pathogenesis of bacterial infections. In Salmonella enterica serovar Typhimurium (S. Typhimurium, several genes, including virulence genes, are regulated by ppGpp when bacteria are under the stringent response. To understand the control of virulence genes by ppGpp in S. Typhimurium, agarose 2-dimensional electrophoresis (2-DE combined with mass spectrometry was used and a comprehensive 2-DE reference map of amino acid-starved S. Typhimurium strain SH100, a derivative of ATCC 14028, was established. Results Of the 366 examined spots, 269 proteins were successfully identified. The comparative analysis of the wild-type and ppGpp0 mutant strains revealed 55 proteins, the expression patterns of which were affected by ppGpp. Using a mouse infection model, we further identified a novel virulence-associated factor, STM3169, from the ppGpp-regulated and Salmonella-specific proteins. In addition, Salmonella strains carrying mutations in the gene encoding STM3169 showed growth defects and impaired growth within macrophage-like RAW264.7 cells. Furthermore, we found that expression of stm3169 was controlled by ppGpp and SsrB, a response regulator of the two-component system located on Salmonella pathogenicity island 2. Conclusions A proteomic approach using a 2-DE reference map can prove a powerful tool for analyzing virulence factors and the regulatory network involved in Salmonella pathogenesis. Our results also provide evidence of a global response mediated by ppGpp in S. enterica.

  4. Surface treated polypropylene (PP) fibres for reinforced concrete

    Energy Technology Data Exchange (ETDEWEB)

    López-Buendía, Angel M., E-mail: buendia@uv.es [AIDICO Technological Institute of Construction, Benjamin Franklin 17, 46380 Paterna, Valencia (Spain); Romero-Sánchez, María Dolores [AIDICO Technological Institute of Construction, Marble Technical Unit, Camí de Castella 4, 03660 Novelda. Alicante (Spain); Climent, Verónica [Lafarge Cementos, Polígono Sepes, Isaac Newton s/n, 46500 Sagunto, Valencia (Spain); Guillem, Celia [AIDICO Technological Institute of Construction, Marble Technical Unit, Camí de Castella 4, 03660 Novelda. Alicante (Spain)

    2013-12-15

    Surface treatments on a polypropylene (PP) fibre have contributed to the improvement of fibre/concrete adhesion in fibre-reinforced concrete. The treatments to the PP fibre were characterized by contact angle measurements, ATR-IR and XPS to analyse chemical alterations. The surface topography and fibre/concrete interaction were analysed by several microscopic techniques, namely optical petrographic, and scanning electron microscopy. Treatment modified the surface chemistry and topography of the fibre by introducing sodium moieties and created additional fibre surface roughness. Modifications in the fibre surface led to an increase in the adhesion properties between the treated fibres and concrete and an improvement in the mechanical properties of the fibre-reinforced concrete composite as compared to the concrete containing untreated PP fibres. Compatibility with the concrete and increased roughness and mineral surface was also improved by nucleated portlandite and ettringite mineral association anchored on the alkaline PP fibre surface, which is induced during treatment.

  5. Visualization of the dynamic multimerization of human Cytomegalovirus pp65 in punctuate nuclear foci

    International Nuclear Information System (INIS)

    Cui Zongqiang; Zhang Ke; Zhang Zhiping; Liu Yalan; Zhou Yafeng; Wei Hongping; Zhang Xian-En

    2009-01-01

    The phosphorylated protein pp65 of human Cytomegalovirus (HCMV) is the predominant virion protein and the major tegument constituent. It plays important roles in HCMV infection and virion assembly. Live cell imaging and fluorescence recovery after photobleaching (FRAP) analysis showed that HCMV pp65 accumulated dynamically in punctuate nuclear foci when transiently expressed in mammalian cells. Fluorescence resonance energy transfer (FRET) imaging disclosed that pp65 can self-interact in its localization foci. Yeast two-hybrid assay verified that pp65 is a self-associating protein, and the N-terminal amino acids 14-22 were determined to be essential for pp65 self-association. However, these amino acids were not related to pp65 localization in the specific nuclear foci. The interaction of pp65 and ppUL97 was also studied by FRET microscopy, and the result suggested that there is another signal sequence in pp65, being the ppUL97 phosphorylation site, that is responsible for localization of pp65 in nuclear foci. These results help to understand the function of pp65 in HCMV infection and virion morphogenesis.

  6. Evaluation of the effect of the incorporation of rubber tire waste particles on the properties of PP, HIPS and PP/HIPS matrices

    Directory of Open Access Journals (Sweden)

    Larissa Stieven Montagna

    2013-01-01

    Full Text Available In recent years, the consumption of plastics has been increasing and as consequence, the waste generated has also increased. Rubber tire (RT waste is another residue which causes significant problems to society. In view of the considerable amounts of RT waste generated, this study aimed to evaluate the influence of the incorporation of RT particles into post-consumer thermoplastic matrices such as polypropylene (PP, high impact polystyrene (HIPS and PP/HIPS blends and the modification of the physical, morphological, rheological and mechanical properties. The particle sizes of the RT used were <500 and 500-1000 μm. The RT content was 10% w/w and the weight ratio for the PP/HIPS blend was 4/1, with processing by injection molding. The results showed that the smaller (500 μm particle size led to a decrease in the melt flow rate (MFR of the PP/RT composites (increased viscosity and an increase for the HIPS/RT composites. On the other hand, the larger particles (1000 μm led to a decrease in the mechanical performance of the PP/RT and HIPS/RT blends when compared with the neat polymers (PP and HIPS post-consumer. The observed decrease in the mechanical properties of these composites was due to weak filler/matrix interactions, which can be visualized in images by scanning electron microscopy (SEM of the fracture surface after tensile testing.

  7. High energy pp and anti-pp elastic scattering in nucleon valence core model

    International Nuclear Information System (INIS)

    Islam, M.M.; Fearnley, T.

    1986-01-01

    Connection between the valence core model and the effective QCD models of nucleon structure is pointed out. Also, implication of recent anti-pp differential cross section measurements at 53 GeV on our previous calculations is discussed

  8. Intermittency patterns in pp collisions at 360 GeV/c

    International Nuclear Information System (INIS)

    Singh, J.B.; Kohli, J.M.

    1991-01-01

    The intermittency effect has been observed in pp collisions at 360 GeV/c and the strength decreases with the increase in multiplicity. The low multiplicity events in pp data (n ch ≤ 8), anti pp collisions (n ch ≤ 15) at Collider energy and elementary interaction (e + e - , μp) samples have almost the same strength. Most likely, few sources seem to contribute at lower multiplications. The intermittency effect is less in pp data compared to e + e - data, however it is fairly strong as compared to nucleus data. The presently used hadronization models DPM, LUND and FRITIOF do not reproduce the results fully. (orig.)

  9. Action of the protoporphyrin-Ix (Pp-Ix) in the life period of Drosophila mutants deficient in endogenous antioxidants; Accion de la protoporfirina-IX (PP-IX) en el periodo de vida de mutantes de Drosophila deficientes en antioxidantes endogenos

    Energy Technology Data Exchange (ETDEWEB)

    Vidal E, L. M.

    2012-07-01

    The human being is daily exposed to free radicals or reactive oxygen species (Ros), as a result of the breathing and the interactions with xenobiotics that can cause irreversible lesions in molecules and cellular structures and that they are associated to diseases like the cancer, neuro degenerative and to the acceleration of the normal process of aging. Fortunately, to reduce the damaging effect of the Ros the cell has endogenous antioxidant systems constituted by antioxidant enzymes as: the superoxide dismutase (Sod), the catalase (Cat), and the glutathione peroxidase and reductase. Even, when these systems are not enough, we find to the exogenous antioxidants that cooperate in the balance of the Ros, as the porphyrins that include to the chlorophyllin, the hemin and the bilirubin among others. The protoporphyrin-Ix (Pp-Ix) is a tetra pyrrole without metallic center with antimutagenic and antioxidant activity similar to that of the chlorophyllin. However, is also known that their over-expression has toxic effects, because induces Ros. In Drosophila melanogaster, recently was found that the Pp-Ix have dual action anti and persistent mutagenic. One of their possible mechanism to act like mutagen is through the Ros induction. To evaluate this possibility and based in that the increase in the Ros levels can accelerate the aging process, in the present work the Pp-Ix role was evaluated, in the life period of Drosophila melanogaster strains deficient in Sod and Cat, sensitive to radiation or oxidative stress (rad, whd and flr{sup 3}) and a wild one as control (C-S). Females and males of each strain were treated chronically for separate with sucrose or Pp-Ix and every 15 days a group of each sex was irradiated with 10 Gy of gamma rays. The results indicated that the chronic treatment with Pp-Ix and in combination with radiation, increased the life period of the C-S strain. The Sod strain had a contrary effect and this effect was pronounced with the combined treatment of

  10. Interpretation of K+¯pair production in pp collisions

    Science.gov (United States)

    Dzyuba, A.; Büscher, M.; Hanhart, C.; Kleber, V.; Koptev, V.; Ströher, H.; Wilkin, C.

    2008-10-01

    A combined analysis of the published data on the pp → dK +¯0 reaction at excess energies of 47.4MeV and 104.7MeV is presented that takes into account final-state interactions in both the K +¯0 and ¯0 d channels. The strong attraction of the antikaons with nucleons, already noted for the ppppK + K - reaction, leads here to very different ¯0 d and K+d distributions, with the former being dominantly in an s -wave and the latter in a p -wave. Evidence is also found from the K +¯0 distributions for the production of the a 0 +(980) scalar resonance. The inclusion of both final-state interactions improves the description of the energy dependence of the pp → dK +¯0 total cross-section.

  11. Pressure, flow and hydraulic interference measurements in ONKALO at Olkiluoto, drillholes ONK-PP262 and ONK-PP274

    International Nuclear Information System (INIS)

    Hurmerinta, E.; Pekkanen, J.; Komulainen, J.; Rouhiainen, P.

    2012-01-01

    The general purpose of these studies is to characterize the fracture network and groundwater flow properties in a volume of rock, which is representative of the rock close to deposition holes. As a part of the studies hydraulic tests and flow measurements were applied in two drillholes in hydraulically poorly conductive bedrock. This report presents the principles of the methods as well as the results of the measurements carried out in the underground facilities of ONKALO. The measurements were conducted in drillholes ONK-PP262 and ONK-PP274 between May 9, 2010 and June 9, 2011. The aim of the measurements was to obtain pressure in the closed drillholes, to detect water yielding fractures by flow measurements, to obtain transmissivity with overpressure and drawdown tests and to study hydraulic interference between the drillholes by cross-hole hydraulic tests. The PFL DIFF probe was used to detect flow within single fractures in the drillhole. Transmissive water yielding fractures were found at depths 17.9 m, 16.9 m and 16.4 m in ONK-PP262 and at depths 19.8 m and 19.5 m in ONK-PP274. The cross-hole hydraulic tests included three basic phases. Flow was measured in one drillhole when the other drillhole was open, closed or overpressurized. The cross-hole hydraulic tests were carried out to both directions in the two drillholes. (orig.)

  12. Noninvasive murine glioma detection improved following photobleaching of skin PpIX fluorescence

    Science.gov (United States)

    Gibbs-Strauss, Summer L.; Davis, Scott C.; O'Hara, Julia A.; Hoopes, P. Jack; Hasan, Tayyaba; Pogue, Brian W.

    2008-02-01

    Aminolevulinic Acid (ALA) is a prodrug which can be administered to cells, animals or patients after which it is transformed via the Heme synthesis pathway into the fluorescent molecule Protoporphyrin IX (PpIX). PpIX has been shown to be useful as both a photosensitizer for photodynamic therapy (PDT) and as a fluorescence imaging contrast agent. The ALA-PpIX system not only provides contrast for fluorescence imaging but also gives information about the metabolic activity of the imaged tissue and thus could be useful for monitoring cancer therapy. In the current study skin photobleaching was examined to determine if PpIX fluorescence contrast in malignant brain tumors could be better visualized noninvasively. Red light photobleaching decreased skin PpIX fluorescence and increased the ability to noninvasively quantify PpIX fluorescence in murine gliomas, as in vivo measurements of mean PpIX fluorescence more closely matched ex vivo quantification following skin photobleaching. Three doses of blue light photobleaching (4 J/cm2, 8 J/cm2 and 12 J/cm2) were tested and determined to give similar levels of skin photobleaching as well as a similar window of decreased skin PpIX fluorescence for noninvasive fluorescence imaging following the photobleaching dose administration.

  13. SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Sung Jun [Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States; Ni, Lisheng [Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States; Osinski, Adam [Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States; Tomchick, Diana R. [Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States; Brautigam, Chad A. [Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, United States; Luo, Xuelian [Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States

    2017-10-24

    The Hippo pathway controls tissue growth and homeostasis through a central MST-LATS kinase cascade. The scaffold protein SAV1 promotes the activation of this kinase cascade, but the molecular mechanisms remain unknown. Here, we discover SAV1-mediated inhibition of the PP2A complex STRIPAKSLMAP as a key mechanism of MST1/2 activation. SLMAP binding to autophosphorylated MST2 linker recruits STRIPAK and promotes PP2A-mediated dephosphorylation of MST2 at the activation loop. Our structural and biochemical studies reveal that SAV1 and MST2 heterodimerize through their SARAH domains. Two SAV1–MST2 heterodimers further dimerize through SAV1 WW domains to form a heterotetramer, in which MST2 undergoes trans-autophosphorylation. SAV1 directly binds to STRIPAK and inhibits its phosphatase activity, protecting MST2 activation-loop phosphorylation. Genetic ablation of SLMAP in human cells leads to spontaneous activation of the Hippo pathway and alleviates the need for SAV1 in Hippo signaling. Thus, SAV1 promotes Hippo activation through counteracting the STRIPAKSLMAP PP2A phosphatase complex.

  14. Core drilling of drillholes OL-PP66-69 at Olkiluoto 2008

    International Nuclear Information System (INIS)

    Kuusirati, J.; Tarvainen, A.-M.

    2009-04-01

    Suomen Malmi Oy (Smoy) core drilled four 24.88 - 25.39 m long investigation drillholes at Olkiluoto in June 2008. The identification numbers of the holes are OL-PP66, OL-PP67, OL-PP68 and OL-PP69. The drillholes are 75.7 mm by diameter. Drillholes were core drilled with the diamond drill rig Diamec 1000. The drilling water was taken from the ONKALO drilling water pipeline and premixed sodium fluorescein was used as a label agent in the drilling water. The labelled drilling water was driven to the drilling places in a tank. In addition to drilling the drill cores were logged and reported by geologist. During geological investigation the following parameters were logged: lithology, foliation, fracture parameters, fractured zones, core loss, weathering, fracture frequency, RQD and rock quality. The main rock types in the drillholes are diatexitic and veined gneisses and pegmatitic granite. The average fracture frequency in holes varied from 3.9 pcs/m to 5.8 pcs/m. The average RQD values varied from 84 % to 93 %. In the drillhole OL-PP66 two fractured zones were penetrated and in OL-PP69 one fractured zone. The drill cores OL-PP67 and OL-PP68 showed no fractured zones. Smoy also carried out optical imaging of the drillholes. The assignment included the field work and the data processing. This report describes the field operation, the equipment as well as the processing procedures and shows the obtained results and their quality. The raw and processed data are delivered digitally in WellCAD and PDF format. (orig.)

  15. Harpin-induced expression and transgenic overexpression of the phloem protein gene AtPP2-A1 in Arabidopsis repress phloem feeding of the green peach aphid Myzus persicae

    Directory of Open Access Journals (Sweden)

    Sun Weiwei

    2011-01-01

    Full Text Available Abstract Background Treatment of plants with HrpNEa, a protein of harpin group produced by Gram-negative plant pathogenic bacteria, induces plant resistance to insect herbivores, including the green peach aphid Myzus persicae, a generalist phloem-feeding insect. Under attacks by phloem-feeding insects, plants defend themselves using the phloem-based defense mechanism, which is supposed to involve the phloem protein 2 (PP2, one of the most abundant proteins in the phloem sap. The purpose of this study was to obtain genetic evidence for the function of the Arabidopsis thaliana (Arabidopsis PP2-encoding gene AtPP2-A1 in resistance to M. persicae when the plant was treated with HrpNEa and after the plant was transformed with AtPP2-A1. Results The electrical penetration graph technique was used to visualize the phloem-feeding activities of apterous agamic M. persicae females on leaves of Arabidopsis plants treated with HrpNEa and an inactive protein control, respectively. A repression of phloem feeding was induced by HrpNEa in wild-type (WT Arabidopsis but not in atpp2-a1/E/142, the plant mutant that had a defect in the AtPP2-A1 gene, the most HrpNEa-responsive of 30 AtPP2 genes. In WT rather than atpp2-a1/E/142, the deterrent effect of HrpNEa treatment on the phloem-feeding activity accompanied an enhancement of AtPP2-A1 expression. In PP2OETAt (AtPP2-A1-overexpression transgenic Arabidopsis thaliana plants, abundant amounts of the AtPP2-A1 gene transcript were detected in different organs, including leaves, stems, calyces, and petals. All these organs had a deterrent effect on the phloem-feeding activity compared with the same organs of the transgenic control plant. When a large-scale aphid population was monitored for 24 hours, there was a significant decrease in the number of aphids that colonized leaves of HrpNEa-treated WT and PP2OETAt plants, respectively, compared with control plants. Conclusions The repression in phloem-feeding activities of

  16. Harpin-induced expression and transgenic overexpression of the phloem protein gene AtPP2-A1 in Arabidopsis repress phloem feeding of the green peach aphid Myzus persicae.

    Science.gov (United States)

    Zhang, Chunling; Shi, Haojie; Chen, Lei; Wang, Xiaomeng; Lü, Beibei; Zhang, Shuping; Liang, Yuan; Liu, Ruoxue; Qian, Jun; Sun, Weiwei; You, Zhenzhen; Dong, Hansong

    2011-01-13

    Treatment of plants with HrpNEa, a protein of harpin group produced by Gram-negative plant pathogenic bacteria, induces plant resistance to insect herbivores, including the green peach aphid Myzus persicae, a generalist phloem-feeding insect. Under attacks by phloem-feeding insects, plants defend themselves using the phloem-based defense mechanism, which is supposed to involve the phloem protein 2 (PP2), one of the most abundant proteins in the phloem sap. The purpose of this study was to obtain genetic evidence for the function of the Arabidopsis thaliana (Arabidopsis) PP2-encoding gene AtPP2-A1 in resistance to M. persicae when the plant was treated with HrpNEa and after the plant was transformed with AtPP2-A1. The electrical penetration graph technique was used to visualize the phloem-feeding activities of apterous agamic M. persicae females on leaves of Arabidopsis plants treated with HrpNEa and an inactive protein control, respectively. A repression of phloem feeding was induced by HrpNEa in wild-type (WT) Arabidopsis but not in atpp2-a1/E/142, the plant mutant that had a defect in the AtPP2-A1 gene, the most HrpNEa-responsive of 30 AtPP2 genes. In WT rather than atpp2-a1/E/142, the deterrent effect of HrpNEa treatment on the phloem-feeding activity accompanied an enhancement of AtPP2-A1 expression. In PP2OETAt (AtPP2-A1-overexpression transgenic Arabidopsis thaliana) plants, abundant amounts of the AtPP2-A1 gene transcript were detected in different organs, including leaves, stems, calyces, and petals. All these organs had a deterrent effect on the phloem-feeding activity compared with the same organs of the transgenic control plant. When a large-scale aphid population was monitored for 24 hours, there was a significant decrease in the number of aphids that colonized leaves of HrpNEa-treated WT and PP2OETAt plants, respectively, compared with control plants. The repression in phloem-feeding activities of M. persicae as a result of AtPP2-A1 overexpression, and

  17. Radiation Improved Mechanical and Thermal Property of PP/HDPE

    International Nuclear Information System (INIS)

    Chaisupaditsin, M.; Thammit, C.; Techakiatkul, C.

    1998-01-01

    The mechanical properties, thermal properties and gel contents of PP-irradiated HDPE blends were studied. HDPE was gamma irradiated in the dose range of 10-30 kGy. The ratios of polymer blends of 30PP:70HDPE was mixed by a twin screw extruder at speed of 50 rpm. Irradiated HDPE with 30 kGy showed the highest gel contents. The blends ratio of 30PP:70HDPE (30 kGy) shows better heat resistance than the blends with non-irradiated HDPE. With increasing the radiation doses, the mechanical properties of the blends were improved

  18. pp spin correlations at high p/sub T/

    International Nuclear Information System (INIS)

    Auer, I.P.; Colton, E.; Ditzler, W.R.

    1980-01-01

    New data are presented for measurements of the spin correlation in pp reactions with longitudinally polarized beam and target. Data were obtained at 11.75 GeV/c for both elastic scattering and for π + - and π - -production at high p/sub T/ in pp reactions at 11.75 GeV/c. A comparison is made with recent predictions of quark-parton models

  19. Elevated Hippocampal Cholinergic Neurostimulating Peptide precursor protein (HCNP-pp) mRNA in the amygdala in major depression.

    Science.gov (United States)

    Bassi, Sabrina; Seney, Marianne L; Argibay, Pablo; Sibille, Etienne

    2015-04-01

    The amygdala is innervated by the cholinergic system and is involved in major depressive disorder (MDD). Evidence suggests a hyper-activate cholinergic system in MDD. Hippocampal Cholinergic Neurostimulating Peptide (HCNP) regulates acetylcholine synthesis. The aim of the present work was to investigate expression levels of HCNP-precursor protein (HCNP-pp) mRNA and other cholinergic-related genes in the postmortem amygdala of MDD patients and matched controls (females: N = 16 pairs; males: N = 12 pairs), and in the mouse unpredictable chronic mild stress (UCMS) model that induced elevated anxiety-/depressive-like behaviors (females: N = 6 pairs; males: N = 6 pairs). Results indicate an up-regulation of HCNP-pp mRNA in the amygdala of women with MDD (p < 0.0001), but not males, and of UCMS-exposed mice (males and females; p = 0.037). HCNP-pp protein levels were investigated in the human female cohort, but no difference was found. There were no differences in gene expression of acetylcholinesterase (AChE), muscarinic (mAChRs) or nicotinic receptors (nAChRs) between MDD subjects and controls or UCMS and control mice, except for an up-regulation of AChE in UCMS-exposed mice (males and females; p = 0.044). Exploratory analyses revealed a baseline expression difference of cholinergic signaling-related genes between women and men (p < 0.0001). In conclusion, elevated amygdala HCNP-pp expression may contribute to mechanisms of MDD in women, potentially independently from regulating the cholinergic system. The differential expression of genes between women and men could also contribute to the increased vulnerability of females to develop MDD. Copyright © 2015 Elsevier Ltd. All rights reserved.

  20. Difference flow and electrical conductivity measurements at the Olkiluoto site in Eurajoki, drillholes OL-PP66 - OL-PP69

    International Nuclear Information System (INIS)

    Poellaenen, J.

    2009-04-01

    The Posiva Flow Log, Difference Flow Method (PFL DIFF) uses a flowmeter that incorporates a flow guide and can be used for relatively quick determinations of hydraulic conductivity and hydraulic head in fractures/fractured zones in cored drillholes. This report presents the principles of the method and the results of measurements carried out in drillholes OL-PP66, OL-PP67, OL-PP68 and OL-PP69 at the Olkiluoto investigation site in August 2008. All the drillholes discussed in this report are ground holes. The same measuring programme was employed in all four drillholes. The section length of the flow guide was either 2 m or 0.5 m. Flow into the drillhole or from the drillhole to the bedrock was measured within the section lengths and carried out in both pumped and natural (i.e. un-pumped) conditions. Calculations of the transmissivity (T) and the hydraulic head (h) of the zones are shown in the results. The device used includes a sensor for single point resistance (SPR). SPR was measured in connection with flow measurements. The electrical conductivity (EC) of fracture-specific water was measured in chosen fractures in some of the drillholes. Fractures were selected on the basis of the measured flow from fracture to drillhole. The EC of the drillhole water was also measured. (orig.)

  1. Scalar fields nonminimally coupled to pp waves

    International Nuclear Information System (INIS)

    Ayon-Beato, Eloy; Hassaiene, Mokhtar

    2005-01-01

    Here, we report pp waves configurations of three-dimensional gravity for which a scalar field nonminimally coupled to them acts as a source. In absence of self-interaction the solutions are gravitational plane waves with a profile fixed in terms of the scalar wave. In the self-interacting case, only power-law potentials parameterized by the nonminimal coupling constant are allowed by the field equations. In contrast with the free case the self-interacting scalar field does not behave like a wave since it depends only on the wave-front coordinate. We address the same problem when gravitation is governed by topologically massive gravity and the source is a free scalar field. From the pp waves derived in this case, we obtain at the zero topological mass limit, new pp waves solutions of conformal gravity for any arbitrary value of the nonminimal coupling parameter. Finally, we extend these solutions to the self-interacting case of conformal gravity

  2. Symmetrized quartic polynomial oscillators and their partial exact solvability

    Czech Academy of Sciences Publication Activity Database

    Znojil, Miloslav

    2016-01-01

    Roč. 380, č. 16 (2016), s. 1414-1418 ISSN 0375-9601 R&D Projects: GA ČR GA16-22945S Institutional support: RVO:61389005 Keywords : Quantum bound states * Non-numerical methods * Piecewise analytic potentials * Quartic oscillators * Quasi-extact states Subject RIV: BE - Theoretical Physics Impact factor: 1.772, year: 2016

  3. Partial wave analysis of anti pp → anti ΛΛ

    International Nuclear Information System (INIS)

    Bugg, D.V.

    2004-01-01

    A partial wave analysis of PS185 data for anti pp → anti ΛΛ is presented. A 3 S 1 cusp is identified in the inverse process anti ΛΛ→ anti p p at threshold, using detailed balance to deduce cross sections from anti pp → anti ΛΛ. Partial wave amplitudes for anti pp 3 P 0 , 3 F 3 , 3 D 3 and 3 G 3 exhibit a behaviour very similar to resonances observed in Crystal Barrel data. With this identification, the anti pp → anti ΛΛ data then provide evidence for a new I=0, J PC =1 - resonance with mass M = 2290 ±20 MeV, Γ= 275 ±35 MeV, coupling to both 3 S 1 and 3 D 1 . (orig.)

  4. Tailored sPP/Silica Nanocomposite for Ecofriendly Insulation of Extruded HVDC Cable

    Directory of Open Access Journals (Sweden)

    Bin Dang

    2015-01-01

    Full Text Available Cross-linked polyethylene (XLPE is a thermosetting material that cannot be recycled at the end of its lifetime. This study investigated the potential of syndiotactic polypropylene (sPP/silica as an ecofriendly extruded insulation system for HVDC cables. We investigated the morphology, Fourier transform infrared, and thermal, thermomechanical, and electrical behaviors of sPP modified with 0.5–3% nanosilica. We found that the silica/sPP nanocomposite without cross-linking offered a suitable mechanical modulus at room temperature and sufficient intensity at high temperatures, and adding nanosilica modified by a silane coupling agent to the sPP resulted in significant DC resistivity and space charge improvement. The optimal nanosilica content in the sPP was determined by balancing the mechanical and thermomechanical characteristics and the DC resistivity. The sPP/silica nanocomposite reported here shows great potential as a candidate insulation material for future ecofriendly extruded HVDC cables.

  5. Structural changes of PP with different isotacticity induced by γ-irradiation

    International Nuclear Information System (INIS)

    Wang Shaofeng; Wei Genshuan; Qiao Jinliang

    2000-01-01

    The morphology of i-PP with different isotacticity under high absorbed dose were studied with the measurements of crystallinity, crystallite size, melting heat and melting point by x-ray diffraction and DSC methods respectively. The results indicate that the changes are not only related to the heat history but also related to the isotacticity of i-PP. In generally, the higher the isotacticity of i-PP, the less morphology changes, and the morphology of annealing samples change less than the virgin powder samples. It means that the annealed i-PP with higher isotacticity is more stable to radiation both in air and vacuum conditions. (author)

  6. Action of the protoporphyrin-Ix (Pp-Ix) in the life period of Drosophila mutants deficient in endogenous antioxidants

    International Nuclear Information System (INIS)

    Vidal E, L. M.

    2012-01-01

    The human being is daily exposed to free radicals or reactive oxygen species (Ros), as a result of the breathing and the interactions with xenobiotics that can cause irreversible lesions in molecules and cellular structures and that they are associated to diseases like the cancer, neuro degenerative and to the acceleration of the normal process of aging. Fortunately, to reduce the damaging effect of the Ros the cell has endogenous antioxidant systems constituted by antioxidant enzymes as: the superoxide dismutase (Sod), the catalase (Cat), and the glutathione peroxidase and reductase. Even, when these systems are not enough, we find to the exogenous antioxidants that cooperate in the balance of the Ros, as the porphyrins that include to the chlorophyllin, the hemin and the bilirubin among others. The protoporphyrin-Ix (Pp-Ix) is a tetra pyrrole without metallic center with antimutagenic and antioxidant activity similar to that of the chlorophyllin. However, is also known that their over-expression has toxic effects, because induces Ros. In Drosophila melanogaster, recently was found that the Pp-Ix have dual action anti and persistent mutagenic. One of their possible mechanism to act like mutagen is through the Ros induction. To evaluate this possibility and based in that the increase in the Ros levels can accelerate the aging process, in the present work the Pp-Ix role was evaluated, in the life period of Drosophila melanogaster strains deficient in Sod and Cat, sensitive to radiation or oxidative stress (rad, whd and flr 3 ) and a wild one as control (C-S). Females and males of each strain were treated chronically for separate with sucrose or Pp-Ix and every 15 days a group of each sex was irradiated with 10 Gy of gamma rays. The results indicated that the chronic treatment with Pp-Ix and in combination with radiation, increased the life period of the C-S strain. The Sod strain had a contrary effect and this effect was pronounced with the combined treatment of Pp

  7. PP2A contributes to endothelial death in high glucose: inhibition by benfotiamine.

    Science.gov (United States)

    Du, Y; Kowluru, A; Kern, T S

    2010-12-01

    Endothelial death is critical in diabetic vascular diseases, but regulating factors have been only partially elucidated. Phosphatases play important regulatory roles in cell metabolism, but have not previously been implicated in hyperglycemia-induced cell death. We investigated the role of the phosphatase, type 2A protein phosphatase (PP2A), in hyperglycemia-induced changes in signaling and death in bovine aortic endothelial cells (BAEC). We explored also the influence of benfotiamine on this phosphatase. Activation of PP2A was assessed in BAEC by the extent of methylation and measurement of activity, and the enzyme was inhibited using selective pharmacological (okadaic acid, sodium fostriecin) and molecular (small interfering RNA) approaches. BAECs cultured in 30 mM glucose significantly increased PP2A methylation and activity, and PP2A inhibitors blocked these abnormalities. PP2A activity was increased also in aorta and retina from diabetic rats. NF-κB activity and cell death in BAEC were significantly increased in 30 mM glucose and inhibited by PP2A inhibition. NF-κB played a role in the hyperglycemia-induced death of BAEC, since blocking its translocation with SN50 also inhibited cell death. Inhibition of PP2A blocked the hyperglycemia-induced dephosphorylation of NF-κB and Bad, thus favoring cell survival. Incubation of benfotiamine with BAEC inhibited the high glucose-induced activation of PP2A and NF-κB and cell death, as well as several other metabolic defects, which likewise were inhibited by inhibitors of PP2A. Activation of PP2A contributes to endothelial cell death in high glucose, and beneficial actions of benfotiamine are due, at least in part, to inhibition of PP2A activation.

  8. Comments about anti-pp collisions

    International Nuclear Information System (INIS)

    Jung, M.

    1978-01-01

    A review concerning specific properties of anti-pp collisions has been done through the summary of several theoretical and experimental papers. Some new experimental measurements are suggested towards the analysis of different already known hadronic processes

  9. PP65 antigenemia in the diagnosis of cytomegalovirus infection in AIDS patients

    Directory of Open Access Journals (Sweden)

    RC Capela

    2012-01-01

    Full Text Available Cytomegalovirus causes significant morbidity and mortality in AIDS patients and those having undergone bone marrow or another transplant. PP65 antigenemia is based on detecting viral antigen in peripheral blood leukocytes through immunochemistry and by monitoring the infection in immunocompromised individuals. The present study aimed to set up this diagnostic technique in AIDS patients with active cytomegalovirus infection and verify its occurrence in the Botucatu region of São Paulo state, Brazil. Fifty patients, 35 men and 15 women aged from 24 to 69 years, were recruited from those attended at the Department of Tropical Diseases of Botucatu Medical School, UNESP, and divided into three groups according to CD4+ T lymphocyte counts and antiretroviral treatment. The control group comprised bone marrow transplant patients. Fourteen AIDS patients with low CD4+ cell counts tested positive for PP65 antigenemia, which could predict cytomegalovirus infection and indicate prophylactic treatment.

  10. Universitality features in (pp), (e+e-), and deep inelastic scattering process

    International Nuclear Information System (INIS)

    Zichichi, A.

    1985-01-01

    This paper discusses the use of the correct variables in (pp), (e + e - ), and deep-inelastic scattering (DIS) processes which allow universality features to be established different ways of producing mulihadronic states. The experimental data where (pp) interactions are compared with (e + e - ) are shown. Extrapolations of collider physics are discussed and it is found that the leading effects must be subtracted and the correct variables have to be used if one wants to compare purely hadronic interactions with (e + e - ) and DIS. The new method of studying (pp) and (pp) collisions allows one to put on equal footing the multiparticle systems that are produced in purely hadronic interactions, in (e + e - ) annihilation, and in DIS processes

  11. Symmetrized exponential oscillator

    Czech Academy of Sciences Publication Activity Database

    Znojil, Miloslav

    2016-01-01

    Roč. 31, č. 34 (2016), č. článku 1650195. ISSN 0217-7323 R&D Projects: GA ČR GA16-22945S Institutional support: RVO:61389005 Keywords : quantum bound states * exactly solvable models * Bessel special funciton transcendental secular equation * numerical precision Subject RIV: BE - Theoretical Physics Impact factor: 1.165, year: 2016

  12. Markov constant and quantum instabilities

    Czech Academy of Sciences Publication Activity Database

    Pelantová, E.; Starosta, Š.; Znojil, Miloslav

    2016-01-01

    Roč. 49, č. 15 (2016), s. 155201 ISSN 1751-8113 R&D Projects: GA ČR GA16-22945S Institutional support: RVO:61389005 Keywords : renormalizable quantum theories with ghosts * Pais-Uhlenbeck model * singular spectra * square-well model * number theory analysis * physical applications Subject RIV: BE - Theoretical Physics Impact factor: 1.857, year: 2016

  13. Communication Dependent Control of Multi-Vehicle Formations

    Science.gov (United States)

    2016-05-11

    On Maximizing the Second Smallest Eigen- value of a State-Dependent Graph Laplacian,” IEEE Transactions on Au- tomatic Control, vol. 51, no. 1, pp...Collective Motion With Limited Communication,” IEEE Transactions on Au- tomatic Control, vol. 53, no. 3, pp. 706–719, 2008. [Online]. Available: http

  14. Mechanical and thermal properties of polypropylene (PP) composites filled with modified shell waste

    Energy Technology Data Exchange (ETDEWEB)

    Yao, Z.T., E-mail: sxyzt@126.com [College of Materials Science and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018 (China); Chen, T. [Department of Ocean Science and Engineering, Zhejiang University, Hangzhou 310058 (China); Li, H.Y. [Zhoushan Ocean Research Institute, Zhejiang University, Zhoushan 316021 (China); Xia, M.S., E-mail: msxia@zju.edu.cn [Department of Ocean Science and Engineering, Zhejiang University, Hangzhou 310058 (China); Ye, Y.; Zheng, H. [Department of Ocean Science and Engineering, Zhejiang University, Hangzhou 310058 (China)

    2013-11-15

    Highlights: • Adding modified shell powder could significantly increase the properties of PP. • The modified shell powder could act as a nucleating agent in PP matrix. • The modified shell powder has a potential to be used as a bio-filler. -- Abstract: Shell waste, with its high content of calcium carbonate (CaCO{sub 3}) plus organic matrix, has a potential to be used as a bio-filler. In this work, shell waste was modified by furfural and then incorporated to reinforce polypropylene (PP). The shell waste and modified powder were characterized by means of X-ray diffraction (XRD), scanning electron microscopy equipped with an energy dispersive spectrometer (SEM-EDS), X-ray photoelectronic spectroscopy (XPS), and Fourier transformed infrared spectroscopy (FTIR). The mechanical and thermal properties of neat PP and PP composites were investigated as well. Thermal gravimetric (TG) analyses confirmed the reinforcing role of modified powder in PP composites. The mechanical properties studied showed that adding modified powder could significantly increase the impact strength, elongation at break point and flexural modulus of composites. The maximum incorporation content could reach 15 wt.% with a good balance between toughness and stiffness of PP composites. Differential scanning calorimetry (DSC) results showed that the modified powder could act as a nucleating agent and thus increase the crystallization temperature of PP. Polarized optical microscopy (POM) observation also indicated that the introduction of modified powder could promote the heterogeneous nucleation of PP matrix.

  15. UV stability of HMS-PP (High Melt Strength Polypropylene) obtained by radiation process

    International Nuclear Information System (INIS)

    Oliani, W.L.; Parra, Duclerc F.; Lugao, Ademar B.

    2006-01-01

    HMS-PP in grains was synthesized by the gamma irradiation of PP under a crosslinking atmosphere of acetylene, followed by thermal treatment for radical recombination and thermal treatment for annihilation of the remaining radicals. The UV stability of the material was evaluated in reference to grains. Accelerated weathering test of HMS-PP samples were performed in artificial ultraviolet light and condensation chamber apparatus Comexim (C-UV type) in aging conditions of exposure for 120 hours and 240 hours. The results were compared to the deterioration caused by sunlight and dew under natural exposition. This work investigated changes in mechanical proprieties (elongation and rupture strength) behavior, Infrared Spectroscopy (FTIR), Optical Microscopy (MO), Scanning Electronic Microscopy (SEM) and Rheological properties of HMS-PP. The HMS-PP is more fragile than PP and undergoes predominately chain scission in aggressive environment degradation conditions. (author)

  16. 2 pi production in pp collisions close to threshold

    CERN Document Server

    Bilger, R; Calén, H; Clement, H; Dyring, J; Ekström, C; Fransson, K; Gustafsson, L; Häggström, S; Hoeistad, B; Johanson, J; Johansson, A; Johansson, T; Khoukaz, A; Kilian, K; Kullander, K; Kupsc, A; Marciniewski, P; Morosov, B; Moertsell, A; Oelert, W; Paetzold, J; Ruber, Roger J M Y; Schepkin, M G; Stepaniak, J; Sukhanov, A; Sundberg, P; Turowiecki, A; Wagner, G J; Wilhelmi, Z; Zabierowski, J; Zernov, A; Zlomanczuk, Yu

    2000-01-01

    The reaction pp -> NN pi pi has been measured close to threshold in the energy range from 650 to 775 MeV using the PROMICE/WASA setup at CELSIUS. These data constitute the first exclusive high-statistics measurements of this reaction on a pure hydrogen target, supplying both differential and integral cross sections. The obtained total cross sections are an order of magnitude below previously published bubble-chamber results. Differential spectra for pp -> pp pi sup -pi sup + are close to phase space predictions identifying the production via N*(1440) -> N(pi pi) sub I sub = sub L sub = sub 0 as the dominant process. Possible contributions from dibaryon resonances are discussed.

  17. High pT jet production in pp collisions

    International Nuclear Information System (INIS)

    Eskola, K.J.; Wang, X.N.

    1995-01-01

    Production rates of large p T jets in pp collisions at RHIC and LHC energies are studied using the next-to-leading order calculation of S. D. Ellis, Z. Zunszt and D. Soper. The computed inclusive one-jet cross sections are compared against the CERN and Fermilab jet data from p bar p and pp collisions. The dependence of the results on the choice of the parton distributions and renormalization/factorization scales is investigated

  18. The anti-esophageal cancer cell activity by a novel tyrosine/phosphoinositide kinase inhibitor PP121

    Energy Technology Data Exchange (ETDEWEB)

    Peng, Yi; Zhou, Yajuan [Department of Radiation and Medical Oncology, Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital of Wuhan University, Wuhan 430071 (China); Department of Radiation Oncology, Hubei Cancer Hospital, Wuhan 430071 (China); Cheng, Long [Department of Interventional Radiology, the Second Affiliated Hospital of Soochow University, Soochow University, Suzhou 215001 (China); Hu, Desheng; Zhou, Xiaoyi; Wang, Zhaohua [Department of Radiation Oncology, Hubei Cancer Hospital, Wuhan 430071 (China); Xie, Conghua, E-mail: chxie_65@hotmail.com [Department of Radiation and Medical Oncology, Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital of Wuhan University, Wuhan 430071 (China); Zhou, Fuxiang, E-mail: ZhouFuxiangwuhan@126.com [Department of Radiation and Medical Oncology, Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital of Wuhan University, Wuhan 430071 (China)

    2015-09-11

    Here we explored the potential effect of PP121, a novel dual inhibitor of tyrosine and phosphoinositide kinases, against human esophageal cancer cells. We showed that PP121 exerted potent cytotoxic effect in primary (patient-derived) and established (Eca-109, TE-1 and TE-3 lines) esophageal cancer cells, possibly through activating caspase-3-dependnent apoptosis. PP121 was, however, non-cytotoxic to the normal human esophageal epithelial cells (EECs). At the molecular level, we showed that PP121 blocked Akt-mTOR (mammalian target of rapamycin) activation in esophageal cancer cells, which was restored by introducing a constitutively-active Akt (CA-Akt). Yet, CA-Akt only partly inhibited cytotoxicity by PP121 in Eca-109 cells. Importantly, we showed that PP121 inhibited nuclear factor kappa B (NFκB) signaling activation in esophageal cancer cells, which appeared independent of Akt-mTOR blockage. In vivo, oral administration of PP121 remarkably inhibited Eca-109 xenograft growth in nude mice, and significantly improved mice survival. Further, the immunohistochemistry (IHC) and Western blot assays analyzing xenografted tumors showed that PP121 inhibited Akt-mTOR and NFκB activations in vivo. Together, we demonstrate that PP121 potently inhibits esophageal cancer cells in vitro and in vivo, possibly through concurrently inhibiting Akt-mTOR and NFκB signalings. - Highlights: • PP121 is cytotoxic against primary and established esophageal cancer cells. • PP121 induces caspase-3-dependnent apoptosis in esophageal cancer cells. • PP121 blocks Akt-mTOR activation in esophageal cancer cells. • PP121 inhibits NFκB activation, independent of Akt-mTOR blockage. • PP121 inhibits Eca-109 xenograft growth and Akt-mTOR/NFκB activation in vivo.

  19. Gauge theory description of compactified pp-waves

    International Nuclear Information System (INIS)

    Bertolini, Matteo; Boer, Jan de; Harmark, Troels; Imeroni, Emiliano; Obers, Niels A.

    2003-01-01

    We find a new Penrose limit of AdS 5 xS 5 that gives the maximally symmetric pp-wave background of type-IIB string theory in a coordinate system that has a manifest space-like isometry. This induces a new pp-wave/gauge-theory duality which on the gauge theory side involves a novel scaling limit of N=4 SYM theory. The new Penrose limit, when applied to AdS 5 xS 5 /Z M , yields a pp-wave with a space-like circle. The dual gauge theory description involves a triple scaling limit of an N=2 quiver gauge theory. We present in detail the map between gauge theory operators and string theory states including winding states, and verify agreement between the energy eigenvalues obtained from string theory and those computed in gauge theory, at least to one-loop order in the planar limit. We furthermore consider other related new Penrose limits and explain how these limits can be understood as part of a more general framework. (author)

  20. The spectroscopy analyses of PpIX by ultrasound irradiation and its sonotoxicity in vitro.

    Science.gov (United States)

    Wang, Pan; Wang, Xiaobing; Zhang, Kun; Gao, Kaili; Song, Ming; Liu, Quanhong

    2013-07-01

    Protoporphyrin IX (PpIX) has been used as a sensitizer in photodynamic therapy (PDT) as well as in sonodynamic therapy (SDT). The photo-bleaching of PpIX has been well investigated in many experimental systems and some photo-products have also been identified in PDT. But until now, little information has been reported about the sono-damage of PpIX in SDT. So, the present study was to investigate changes of PpIX properties before and after different ultrasound treatment, and the potential interactions between PpIX, ultrasound and the irradiated cells. In cell-free system, the absorption and fluorescence spectra of PpIX in different solutions were measured by ultraviolet spectrometer and fluorescence spectrophotometer, respectively. The terephthalic acid dosimetry was applied to evaluate the efficiency of ultrasound cavitation by monitoring hydroxyl radical (OH) production on the thermolysis of H2O in the ultrasound field. In in vitro study, confocal microscopy was applied to detect the sub-cellular localization of PpIX in S180 cells before and after ultrasound exposure. Flow cytometry was used to detect the reactive oxygen species (ROS) generation during PpIX-SDT. MTT assay was performed to evaluate the cell viability of S180 cells after SDT treatment with or without ROS scavengers. The results show that PpIX displayed different spectral patterns in different solutions. PpIX was decomposed by ultrasound exposure as measured by the decreased absorption and fluorescence peak values in RPMI-1640 medium. In addition, the decomposition of PpIX was found to be simultaneously accompanied by OH production with increasing output power from ultrasound generator. PpIX at 1μg/ml significantly enhanced the ultrasound induced cavitation as measured by OH generation, and which was greatly eliminated by NaN3, histidine, mannitol, EDTA and catalase, but not by SOD. The in vitro study indicates more PpIX entered into S180 cells after ultrasound exposure. And, the extra-cellular Pp

  1. p-p, p-$\\Lambda$ and $\\Lambda$-$\\Lambda$ correlations studied via femtoscopy in pp reactions at $\\sqrt{s}$ = 7 TeV

    CERN Document Server

    Acharya, Shreyasi; The ALICE collaboration; Adamova, Dagmar; Adolfsson, Jonatan; Aggarwal, Madan Mohan; Aglieri Rinella, Gianluca; Agnello, Michelangelo; Agrawal, Neelima; Ahammed, Zubayer; Ahn, Sang Un; Aiola, Salvatore; Akindinov, Alexander; Al-turany, Mohammad; Alam, Sk Noor; Silva De Albuquerque, Danilo; Aleksandrov, Dmitry; Alessandro, Bruno; Alfaro Molina, Jose Ruben; Ali, Yasir; Alici, Andrea; Alkin, Anton; Alme, Johan; Alt, Torsten; Altenkamper, Lucas; Altsybeev, Igor; Anaam, Mustafa Naji; Andrei, Cristian; Andreou, Dimitra; Andrews, Harry Arthur; Andronic, Anton; Angeletti, Massimo; Anguelov, Venelin; Anson, Christopher Daniel; Anticic, Tome; Antinori, Federico; Antonioli, Pietro; Anwar, Rafay; Apadula, Nicole; Aphecetche, Laurent Bernard; Appelshaeuser, Harald; Arcelli, Silvia; Arnaldi, Roberta; Arnold, Oliver Werner; Arsene, Ionut Cristian; Arslandok, Mesut; Augustinus, Andre; Averbeck, Ralf Peter; Azmi, Mohd Danish; Badala, Angela; Baek, Yong Wook; Bagnasco, Stefano; Bailhache, Raphaelle Marie; Bala, Renu; Baldisseri, Alberto; Ball, Markus; Baral, Rama Chandra; Barbano, Anastasia Maria; Barbera, Roberto; Barile, Francesco; Barioglio, Luca; Barnafoldi, Gergely Gabor; Barnby, Lee Stuart; Ramillien Barret, Valerie; Bartalini, Paolo; Barth, Klaus; Bartsch, Esther; Bastid, Nicole; Basu, Sumit; Batigne, Guillaume; Batyunya, Boris; Batzing, Paul Christoph; Bazo Alba, Jose Luis; Bearden, Ian Gardner; Beck, Hans; Bedda, Cristina; Behera, Nirbhay Kumar; Belikov, Iouri; Bellini, Francesca; Bello Martinez, Hector; Bellwied, Rene; Espinoza Beltran, Lucina Gabriela; Belyaev, Vladimir; Bencedi, Gyula; Beole, Stefania; Bercuci, Alexandru; Berdnikov, Yaroslav; Berenyi, Daniel; Bertens, Redmer Alexander; Berzano, Dario; Betev, Latchezar; Bhaduri, Partha Pratim; Bhasin, Anju; Bhat, Inayat Rasool; Bhatt, Himani; Bhattacharjee, Buddhadeb; Bhom, Jihyun; Bianchi, Antonio; Bianchi, Livio; Bianchi, Nicola; Bielcik, Jaroslav; Bielcikova, Jana; Bilandzic, Ante; Biro, Gabor; Biswas, Rathijit; Biswas, Saikat; Blair, Justin Thomas; Blau, Dmitry; Blume, Christoph; Boca, Gianluigi; Bock, Friederike; Bogdanov, Alexey; Boldizsar, Laszlo; Bombara, Marek; Bonomi, Germano; Bonora, Matthias; Borel, Herve; Borissov, Alexander; Borri, Marcello; Botta, Elena; Bourjau, Christian; Bratrud, Lars; Braun-munzinger, Peter; Bregant, Marco; Broker, Theo Alexander; Broz, Michal; Brucken, Erik Jens; Bruna, Elena; Bruno, Giuseppe Eugenio; Budnikov, Dmitry; Buesching, Henner; Bufalino, Stefania; Buhler, Paul; Buncic, Predrag; Busch, Oliver; Buthelezi, Edith Zinhle; Bashir Butt, Jamila; Buxton, Jesse Thomas; Cabala, Jan; Caffarri, Davide; Caines, Helen Louise; Caliva, Alberto; Calvo Villar, Ernesto; Soto Camacho, Rabi; Camerini, Paolo; Capon, Aaron Allan; Carena, Francesco; Carena, Wisla; Carnesecchi, Francesca; Castillo Castellanos, Javier Ernesto; Castro, Andrew John; Casula, Ester Anna Rita; Ceballos Sanchez, Cesar; Chandra, Sinjini; Chang, Beomsu; Chang, Wan; Chapeland, Sylvain; Chartier, Marielle; Chattopadhyay, Subhasis; Chattopadhyay, Sukalyan; Chauvin, Alex; Cheshkov, Cvetan Valeriev; Cheynis, Brigitte; Chibante Barroso, Vasco Miguel; Dobrigkeit Chinellato, David; Cho, Soyeon; Chochula, Peter; Chowdhury, Tasnuva; Christakoglou, Panagiotis; Christensen, Christian Holm; Christiansen, Peter; Chujo, Tatsuya; Chung, Suh-urk; Cicalo, Corrado; Cifarelli, Luisa; Cindolo, Federico; Cleymans, Jean Willy Andre; Colamaria, Fabio Filippo; Colella, Domenico; Collu, Alberto; Colocci, Manuel; Concas, Matteo; Conesa Balbastre, Gustavo; Conesa Del Valle, Zaida; Contreras Nuno, Jesus Guillermo; Cormier, Thomas Michael; Corrales Morales, Yasser; Cortese, Pietro; Cosentino, Mauro Rogerio; Costa, Filippo; Costanza, Susanna; Crkovska, Jana; Crochet, Philippe; Cuautle Flores, Eleazar; Cunqueiro Mendez, Leticia; Dahms, Torsten; Dainese, Andrea; Damas, Florian Paul AndrÉ; Dani, Sanskruti; Danisch, Meike Charlotte; Danu, Andrea; Das, Debasish; Das, Indranil; Das, Supriya; Dash, Ajay Kumar; Dash, Sadhana; De, Sudipan; De Caro, Annalisa; De Cataldo, Giacinto; De Conti, Camila; De Cuveland, Jan; De Falco, Alessandro; De Gruttola, Daniele; De Marco, Nora; De Pasquale, Salvatore; Derradi De Souza, Rafael; Franz Degenhardt, Hermann; Deisting, Alexander; Deloff, Andrzej; Delsanto, Silvia; Deplano, Caterina; Dhankher, Preeti; Di Bari, Domenico; Di Mauro, Antonio; Di Ruzza, Benedetto; Arteche Diaz, Raul; Dietel, Thomas; Dillenseger, Pascal; Ding, Yanchun; Divia, Roberto; Djuvsland, Oeystein; Dobrin, Alexandru Florin; Domenicis Gimenez, Diogenes; Donigus, Benjamin; Dordic, Olja; Van Doremalen, Lennart Vincent; Dubey, Anand Kumar; Dubla, Andrea; Ducroux, Laurent; Dudi, Sandeep; Duggal, Ashpreet Kaur; Dukhishyam, Mallick; Dupieux, Pascal; Ehlers Iii, Raymond James; Elia, Domenico; Endress, Eric; Engel, Heiko; Epple, Eliane; Erazmus, Barbara Ewa; Erhardt, Filip; Ersdal, Magnus Rentsch; Espagnon, Bruno; Eulisse, Giulio; Eum, Jongsik; Evans, David; Evdokimov, Sergey; Fabbietti, Laura; Faggin, Mattia; Faivre, Julien; Fantoni, Alessandra; Fasel, Markus; Feldkamp, Linus; Feliciello, Alessandro; Feofilov, Grigorii; Fernandez Tellez, Arturo; Ferretti, Alessandro; Festanti, Andrea; Feuillard, Victor Jose Gaston; Figiel, Jan; Araujo Silva Figueredo, Marcel; Filchagin, Sergey; Finogeev, Dmitry; Fionda, Fiorella; Fiorenza, Gabriele; Flor, Fernando; Floris, Michele; Foertsch, Siegfried Valentin; Foka, Panagiota; Fokin, Sergey; Fragiacomo, Enrico; Francescon, Andrea; Francisco, Audrey; Frankenfeld, Ulrich Michael; Fronze, Gabriele Gaetano; Fuchs, Ulrich; Furget, Christophe; Furs, Artur; Fusco Girard, Mario; Gaardhoeje, Jens Joergen; Gagliardi, Martino; Gago Medina, Alberto Martin; Gajdosova, Katarina; Gallio, Mauro; Duarte Galvan, Carlos; Ganoti, Paraskevi; Garabatos Cuadrado, Jose; Garcia-solis, Edmundo Javier; Garg, Kunal; Gargiulo, Corrado; Gasik, Piotr Jan; Gauger, Erin Frances; De Leone Gay, Maria Beatriz; Germain, Marie; Ghosh, Jhuma; Ghosh, Premomoy; Ghosh, Sanjay Kumar; Gianotti, Paola; Giubellino, Paolo; Giubilato, Piero; Glassel, Peter; Gomez Coral, Diego Mauricio; Gomez Ramirez, Andres; Gonzalez, Victor; Gonzalez Zamora, Pedro; Gorbunov, Sergey; Gorlich, Lidia Maria; Gotovac, Sven; Grabski, Varlen; Graczykowski, Lukasz Kamil; Graham, Katie Leanne; Greiner, Leo Clifford; Grelli, Alessandro; Grigoras, Costin; Grigoryev, Vladislav; Grigoryan, Ara; Grigoryan, Smbat; Gronefeld, Julius Maximilian; Grosa, Fabrizio; Grosse-oetringhaus, Jan Fiete; Grosso, Raffaele; Guernane, Rachid; Guerzoni, Barbara; Guittiere, Manuel; Gulbrandsen, Kristjan Herlache; Gunji, Taku; Gupta, Anik; Gupta, Ramni; Bautista Guzman, Irais; Haake, Rudiger; Habib, Michael Karim; Hadjidakis, Cynthia Marie; Hamagaki, Hideki; Hamar, Gergoe; Hamid, Mohammed; Hamon, Julien Charles; Hannigan, Ryan; Haque, Md Rihan; Harlenderova, Alena; Harris, John William; Harton, Austin Vincent; Hassan, Hadi; Hatzifotiadou, Despina; Hayashi, Shinichi; Heckel, Stefan Thomas; Hellbar, Ernst; Helstrup, Haavard; Herghelegiu, Andrei Ionut; Gonzalez Hernandez, Emma; Herrera Corral, Gerardo Antonio; Herrmann, Florian; Hetland, Kristin Fanebust; Hilden, Timo Eero; Hillemanns, Hartmut; Hills, Christopher; Hippolyte, Boris; Hohlweger, Bernhard; Horak, David; Hornung, Sebastian; Hosokawa, Ritsuya; Hota, Jyotishree; Hristov, Peter Zahariev; Huang, Chun-lu; Hughes, Charles; Huhn, Patrick; Humanic, Thomas; Hushnud, Hushnud; Hussain, Nur; Hussain, Tahir; Hutter, Dirk; Hwang, Dae Sung; Iddon, James Philip; Iga Buitron, Sergio Arturo; Ilkaev, Radiy; Inaba, Motoi; Ippolitov, Mikhail; Islam, Md Samsul; Ivanov, Marian; Ivanov, Vladimir; Izucheev, Vladimir; Jacak, Barbara; Jacazio, Nicolo; Jacobs, Peter Martin; Jadhav, Manoj Bhanudas; Jadlovska, Slavka; Jadlovsky, Jan; Jaelani, Syaefudin; Jahnke, Cristiane; Jakubowska, Monika Joanna; Janik, Malgorzata Anna; Jena, Chitrasen; Jercic, Marko; Jevons, Oliver; Jimenez Bustamante, Raul Tonatiuh; Jin, Muqing; Jones, Peter Graham; Jusko, Anton; Kalinak, Peter; Kalweit, Alexander Philipp; Kang, Ju Hwan; Kaplin, Vladimir; Kar, Somnath; Karasu Uysal, Ayben; Karavichev, Oleg; Karavicheva, Tatiana; Karczmarczyk, Przemyslaw; Karpechev, Evgeny; Kebschull, Udo Wolfgang; Keidel, Ralf; Keijdener, Darius Laurens; Keil, Markus; Ketzer, Bernhard Franz; Khabanova, Zhanna; Khan, Ahsan Mehmood; Khan, Shaista; Khan, Shuaib Ahmad; Khanzadeev, Alexei; Kharlov, Yury; Khatun, Anisa; Khuntia, Arvind; Kielbowicz, Miroslaw Marek; Kileng, Bjarte; Kim, Byungchul; Kim, Daehyeok; Kim, Dong Jo; Kim, Eun Joo; Kim, Hyeonjoong; Kim, Jinsook; Kim, Jiyoung; Kim, Minjung; Kim, Se Yong; Kim, Taejun; Kim, Taesoo; Kirsch, Stefan; Kisel, Ivan; Kiselev, Sergey; Kisiel, Adam Ryszard; Klay, Jennifer Lynn; Klein, Carsten; Klein, Jochen; Klein-boesing, Christian; Klewin, Sebastian; Kluge, Alexander; Knichel, Michael Linus; Knospe, Anders Garritt; Kobdaj, Chinorat; Varga-kofarago, Monika; Kohler, Markus Konrad; Kollegger, Thorsten; Kondratyeva, Natalia; Kondratyuk, Evgeny; Konevskikh, Artem; Konopka, Piotr Jan; Konyushikhin, Maxim; Koska, Lukas; Kovalenko, Oleksandr; Kovalenko, Vladimir; Kowalski, Marek; Kralik, Ivan; Kravcakova, Adela; Kreis, Lukas; Krivda, Marian; Krizek, Filip; Kruger, Mario; Kryshen, Evgeny; Krzewicki, Mikolaj; Kubera, Andrew Michael; Kucera, Vit; Kuhn, Christian Claude; Kuijer, Paulus Gerardus; Kumar, Jitendra; Kumar, Lokesh; Kumar, Shyam; Kundu, Sourav; Kurashvili, Podist; Kurepin, Alexander; Kurepin, Alexey; Kuryakin, Alexey; Kushpil, Svetlana; Kvapil, Jakub; Kweon, Min Jung; Kwon, Youngil; La Pointe, Sarah Louise; La Rocca, Paola; Lai, Yue Shi; Lakomov, Igor; Langoy, Rune; Lapidus, Kirill; Lardeux, Antoine Xavier; Larionov, Pavel; Laudi, Elisa; Lavicka, Roman; Lea, Ramona; Leardini, Lucia; Lee, Seongjoo; Lehas, Fatiha; Lehner, Sebastian; Lehrbach, Johannes; Lemmon, Roy Crawford; Leon Monzon, Ildefonso; Levai, Peter; Li, Xiaomei; Li, Xing Long; Lien, Jorgen Andre; Lietava, Roman; Lim, Bong-hwi; Lindal, Svein; Lindenstruth, Volker; Lindsay, Scott William; Lippmann, Christian; Lisa, Michael Annan; Litichevskyi, Vladyslav; Liu, Alwina; Ljunggren, Hans Martin; Llope, William; Lodato, Davide Francesco; Loginov, Vitaly; Loizides, Constantinos; Loncar, Petra; Lopez, Xavier Bernard; Lopez Torres, Ernesto; Lowe, Andrew John; Luettig, Philipp Johannes; Luhder, Jens Robert; Lunardon, Marcello; Luparello, Grazia; Lupi, Matteo; Maevskaya, Alla; Mager, Magnus; Mahmood, Sohail Musa; Maire, Antonin; Majka, Richard Daniel; Malaev, Mikhail; Malik, Qasim Waheed; Malinina, Liudmila; Mal'kevich, Dmitry; Malzacher, Peter; Mamonov, Alexander; Manko, Vladislav; Manso, Franck; Manzari, Vito; Mao, Yaxian; Marchisone, Massimiliano; Mares, Jiri; Margagliotti, Giacomo Vito; Margotti, Anselmo; Margutti, Jacopo; Marin, Ana Maria; Markert, Christina; Marquard, Marco; Martin, Nicole Alice; Martinengo, Paolo; Martinez, Jacobb Lee; Martinez Hernandez, Mario Ivan; Martinez-garcia, Gines; Martinez Pedreira, Miguel; Masciocchi, Silvia; Masera, Massimo; Masoni, Alberto; Massacrier, Laure Marie; Masson, Erwann; Mastroserio, Annalisa; Mathis, Andreas Michael; Toledo Matuoka, Paula Fernanda; Matyja, Adam Tomasz; Mayer, Christoph; Mazzilli, Marianna; Mazzoni, Alessandra Maria; Meddi, Franco; Melikyan, Yuri; Menchaca-rocha, Arturo Alejandro; Meninno, Elisa; Mercado-perez, Jorge; Meres, Michal; Mhlanga, Sibaliso; Miake, Yasuo; Micheletti, Luca; Mieskolainen, Matti Mikael; Mihaylov, Dimitar Lubomirov; Mikhaylov, Konstantin; Mischke, Andre; Mishra, Aditya Nath; Miskowiec, Dariusz Czeslaw; Mitra, Jubin; Mitu, Ciprian Mihai; Mohammadi, Naghmeh; Mohanty, Auro Prasad; Mohanty, Bedangadas; Khan, Mohammed Mohisin; Moreira De Godoy, Denise Aparecida; Perez Moreno, Luis Alberto; Moretto, Sandra; Morreale, Astrid; Morsch, Andreas; Mrnjavac, Teo; Muccifora, Valeria; Mudnic, Eugen; Muhlheim, Daniel Michael; Muhuri, Sanjib; Mukherjee, Maitreyee; Mulligan, James Declan; Gameiro Munhoz, Marcelo; Munning, Konstantin; Arratia Munoz, Miguel Ignacio; Munzer, Robert Helmut; Murakami, Hikari; Murray, Sean; Musa, Luciano; Musinsky, Jan; Myers, Corey James; Myrcha, Julian Wojciech; 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Senyukov, Serhiy; Serradilla Rodriguez, Eulogio; Sett, Priyanka; Sevcenco, Adrian; Shabanov, Arseniy; Shabetai, Alexandre; Shahoyan, Ruben; Shaikh, Wadut; Shangaraev, Artem; Sharma, Anjali; Sharma, Ankita; Sharma, Meenakshi; Sharma, Natasha; Sheikh, Ashik Ikbal; Shigaki, Kenta; Shimomura, Maya; Shirinkin, Sergey; Shou, Qiye; Shtejer Diaz, Katherin; Sibiryak, Yury; Siddhanta, Sabyasachi; Sielewicz, Krzysztof Marek; Siemiarczuk, Teodor; Silvermyr, David Olle Rickard; Simatovic, Goran; Simonetti, Giuseppe; Singaraju, Rama Narayana; Singh, Ranbir; Singh, Randhir; Singhal, Vikas; Sarkar - Sinha, Tinku; Sitar, Branislav; Sitta, Mario; Skaali, Bernhard; Slupecki, Maciej; Smirnov, Nikolai; Snellings, Raimond; Snellman, Tomas Wilhelm; Sochan, Jaroslav; Soncco Meza, Carlos; Song, Jihye; Soramel, Francesca; Sorensen, Soren Pontoppidan; Sozzi, Federica; Sputowska, Iwona Anna; Stachel, Johanna; Stan, Ionel; Stankus, Paul; Stenlund, Evert Anders; Stocco, Diego; Storetvedt, Maksim Melnik; Strmen, Peter; Alarcon Do Passo Suaide, Alexandre; Sugitate, Toru; Suire, Christophe Pierre; Suleymanov, Mais Kazim Oglu; Suljic, Miljenko; Sultanov, Rishat; Sumbera, Michal; Sumowidagdo, Suharyo; Suzuki, Ken; Swain, Sagarika; Szabo, Alexander; Szarka, Imrich; Tabassam, Uzma; Takahashi, Jun; Tambave, Ganesh Jagannath; Tanaka, Naoto; Tarhini, Mohamad; Tariq, Mohammad; Tarzila, Madalina-gabriela; Tauro, Arturo; Tejeda Munoz, Guillermo; Telesca, Adriana; Terrevoli, Cristina; Teyssier, Boris; Thakur, Dhananjaya; Thakur, Sanchari; Thomas, Deepa; Thoresen, Freja; Tieulent, Raphael Noel; Tikhonov, Anatoly; Timmins, Anthony Robert; Toia, Alberica; Topilskaya, Nataliya; Toppi, Marco; Rojas Torres, Solangel; Tripathy, Sushanta; Trogolo, Stefano; Trombetta, Giuseppe; Tropp, Lukas; Trubnikov, Victor; Trzaska, Wladyslaw Henryk; Trzcinski, Tomasz Piotr; Trzeciak, Barbara Antonina; Tsuji, Tomoya; Tumkin, Alexandr; Turrisi, Rosario; Tveter, Trine Spedstad; Ullaland, Kjetil; Umaka, Ejiro Naomi; Uras, Antonio; Usai, Gianluca; Utrobicic, Antonija; Vala, Martin; Van Hoorne, Jacobus Willem; Van Leeuwen, Marco; Vande Vyvre, Pierre; Varga, Dezso; Diozcora Vargas Trevino, Aurora; Vargyas, Marton; Varma, Raghava; Vasileiou, Maria; Vasiliev, Andrey; Vauthier, Astrid; Vazquez Doce, Oton; Vechernin, Vladimir; Veen, Annelies Marianne; Vercellin, Ermanno; Vergara Limon, Sergio; Vermunt, Luuk; Vernet, Renaud; Vertesi, Robert; Vickovic, Linda; Viinikainen, Jussi Samuli; Vilakazi, Zabulon; Villalobos Baillie, Orlando; Villatoro Tello, Abraham; Vinogradov, Alexander; Virgili, Tiziano; Vislavicius, Vytautas; Vodopyanov, Alexander; Volkl, Martin Andreas; Voloshin, Kirill; Voloshin, Sergey; Volpe, Giacomo; Von Haller, Barthelemy; Vorobyev, Ivan; Voscek, Dominik; Vranic, Danilo; Vrlakova, Janka; Wagner, Boris; Wang, Hongkai; Wang, Mengliang; Watanabe, Yosuke; Weber, Michael; Weber, Steffen Georg; Wegrzynek, Adam; Weiser, Dennis Franz; Wenzel, Sandro Christian; Wessels, Johannes Peter; Westerhoff, Uwe; Whitehead, Andile Mothegi; Wiechula, Jens; Wikne, Jon; Wilk, Grzegorz Andrzej; Wilkinson, Jeremy John; Willems, Guido Alexander; Williams, Crispin; Willsher, Emily; Windelband, Bernd Stefan; Witt, William Edward; Xu, Ran; Yalcin, Serpil; Yamakawa, Kosei; Yano, Satoshi; Yin, Zhongbao; Yokoyama, Hiroki; Yoo, In-kwon; Yoon, Jin Hee; Yurchenko, Volodymyr; Zaccolo, Valentina; Zaman, Ali; Zampolli, Chiara; Correa Zanoli, Henrique Jose; Zardoshti, Nima; Zarochentsev, Andrey; Zavada, Petr; Zavyalov, Nikolay; Zbroszczyk, Hanna Paulina; Zhalov, Mikhail; Zhang, Xiaoming; Zhang, Yonghong; Zhang, Zuman; Zhao, Chengxin; Zherebchevskii, Vladimir; Zhigareva, Natalia; Zhou, Daicui; Zhou, You; Zhou, Zhuo; Zhu, Hongsheng; Zhu, Jianhui; Zhu, Ya; Zichichi, Antonino; Zimmermann, Markus Bernhard; Zinovjev, Gennady; Zmeskal, Johann; Zou, Shuguang

    2018-01-01

    We report on the first femtoscopic measurement of baryon pairs, such as p-p, p-$\\Lambda$ and $\\Lambda$-$\\Lambda$, measured by ALICE at the Large Hadron Collider (LHC) in proton-proton collisions at $\\sqrt{s}$ = 7 TeV This study demonstrates the feasibility of such measurements in pp collisions at ultrarelativistic energies. The femtoscopy method is employed to constrain the hyperon-nucleon and hyperon-hyperon interactions, which are still rather poorly understood. A new method to evaluate the influence of residual correlations induced by the decays of resonances and experimental impurities is hereby presented. The p-p, p-$\\Lambda$ and $\\Lambda$-$\\Lambda$ correlation functions were fitted simultaneously with the help of a new tool developed specifically for the femtoscopy analysis in small colliding systems “Correlation Analysis Tool using the Schrödinger Equation” (CATS). Within the assumption that in collisions the three particle pairs originate from a common source, its radius is found to be equal to...

  2. AbetaPP/APLP2 family of Kunitz serine proteinase inhibitors regulate cerebral thrombosis.

    Science.gov (United States)

    Xu, Feng; Previti, Mary Lou; Nieman, Marvin T; Davis, Judianne; Schmaier, Alvin H; Van Nostrand, William E

    2009-04-29

    The amyloid beta-protein precursor (AbetaPP) is best recognized as the precursor to the Abeta peptide that accumulates in the brains of patients with Alzheimer's disease, but less is known about its physiological functions. Isoforms of AbetaPP that contain a Kunitz-type serine proteinase inhibitor (KPI) domain are expressed in brain and, outside the CNS, in circulating blood platelets. Recently, we showed that KPI-containing forms of AbetaPP regulates cerebral thrombosis in vivo (Xu et al., 2005, 2007). Amyloid precursor like protein-2 (APLP2), a closely related homolog to AbetaPP, also possesses a highly conserved KPI domain. Virtually nothing is known of its function. Here, we show that APLP2 also regulates cerebral thrombosis risk. Recombinant purified KPI domains of AbetaPP and APLP2 both inhibit the plasma clotting in vitro. In a carotid artery thrombosis model, both AbetaPP(-/-) and APLP2(-/-) mice exhibit similar significantly shorter times to vessel occlusion compared with wild-type mice indicating a prothrombotic phenotype. Similarly, in an experimental model of intracerebral hemorrhage, both AbetaPP(-/-) and APLP2(-/-) mice produce significantly smaller hematomas with reduced brain hemoglobin content compared with wild-type mice. Together, these results indicate that AbetaPP and APLP2 share overlapping anticoagulant functions with regard to regulating thrombosis after cerebral vascular injury.

  3. One-dimensional Schrodinger equation with non-analytic potential V(x) = -g(2) exp (- vertical bar x vertical bar) and its exact Bessel-function solvability

    Czech Academy of Sciences Publication Activity Database

    Sasaki, R.; Znojil, Miloslav

    2016-01-01

    Roč. 49, č. 44 (2016), č. článku 445303. ISSN 1751-8113 R&D Projects: GA ČR GA16-22945S Institutional support: RVO:61389005 Keywords : non-analytic potentials * bound states * reflection and transmission * exactly solvable * orthogonality theorems * associated Hamiltonians * supersymmetry Subject RIV: BE - Theoretical Physics Impact factor: 1.857, year: 2016

  4. Morse potential, symmetric Morse potential and bracketed bound-state energies

    Czech Academy of Sciences Publication Activity Database

    Znojil, Miloslav

    2016-01-01

    Roč. 31, č. 14 (2016), s. 1650088 ISSN 0217-7323 R&D Projects: GA ČR GA16-22945S Institutional support: RVO:61389005 Keywords : quantum bound states * special functions * Morse potential * symmetrized Morse potential * upper and lower energy estimates * computer-assisted symbolic manipulations Subject RIV: BE - Theoretical Physics Impact factor: 1.165, year: 2016

  5. The PP4R1 sub-unit of protein phosphatase PP4 is essential for inhibition of NF-κB by merkel polyomavirus small tumour antigen.

    Science.gov (United States)

    Abdul-Sada, Hussein; Müller, Marietta; Mehta, Rajni; Toth, Rachel; Arthur, J Simon C; Whitehouse, Adrian; Macdonald, Andrew

    2017-04-11

    Merkel cell carcinoma (MCC) is a highly aggressive skin cancer with a high metastatic potential. The majority of MCC cases are caused by the Merkel cell polyomavirus (MCPyV), through expression of the virus-encoded tumour antigens. Whilst mechanisms attributing tumour antigen expression to transformation are being uncovered, little is known of the mechanisms by which MCPyV persists in the host. We previously identified the MCPyV small T antigen (tAg) as a novel inhibitor of nuclear factor kappa B (NF-kB) signalling and a modulator of the host anti-viral response. Here we demonstrate that regulation of NF-kB activation involves a previously undocumented interaction between tAg and regulatory sub-unit 1 of protein phosphatase 4 (PP4R1). Formation of a complex with PP4R1 and PP4c is required to bridge MCPyV tAg to the NEMO adaptor protein, allowing deactivation of the NF-kB pathway. Mutations in MCPyV tAg that fail to interact with components of this complex, or siRNA depletion of PP4R1, prevents tAg-mediated inhibition of NF-kB and pro-inflammatory cytokine production. Comparison of tAg binding partners from other human polyomavirus demonstrates that interactions with NEMO and PP4R1 are unique to MCPyV. Collectively, these data identify PP4R1 as a novel target for virus subversion of the host anti-viral response.

  6. Polarization in pp → p(baryon)

    International Nuclear Information System (INIS)

    Castillo-Vallejo, Victor M.; Felix, Julian

    2003-01-01

    It's introduced a calculation, which is based on symmetries followed by high energy hadronic interactions, of resonance polarization and specific angular momentum state polarization created in pp → p(baryon)

  7. Characterization of dispersion of a nano composites PP/TiO{sub 2} non modified; Caracterizacao da dispersao dos nanocompositos de PP/TiO{sub 2} nao modificados

    Energy Technology Data Exchange (ETDEWEB)

    Soares, Igor L.; Tavares, Maria I.B.; Silva, Vanessa A. da; Legramanti, Cintia, E-mail: igorl@ima.ufrj.br [Universidade Federal do Rio de Janeiro - UFRJ, Instituto de Macromoleculas - IMA (Brazil); Luetkmeyer, Leandro [Universidades Federais do Mato Grosso - UFMT, Escritorio de Inovacao Tecnologica - EIT (Brazil)

    2011-07-01

    Polymeric nano composites are composite materials where an inorganic particle, which has a dimension in the nanometer range, is dispersed in a polymer matrix. Nano composites, using polypropylene (PP) as matrix polymer and titanium dioxide (TiO{sub 2}) as filler, have great versatility in marketing applications, this factor is inherent in the PP and the inherent ability photo degraded TiO{sub 2} particles. This combination can lead to a widely used material and a degradation time after discharge reduced, there by becoming, a residue of low environmental impact. This study aimed to evaluate the dispersion and particle distribution of TiO{sub 2}, non modified, in PP matrix, using the process of preparation by melt extrusion pathway and characterization of the materials obtained: on the molecular dynamics, using low field NMR solid state, measures the relaxation time spin-network (T{sub 1}H); morphology using XRD technique, and thermal analysis technique with the TGA of pure PP and nano composites PP/TiO{sub 2}. (author)

  8. New KF-PP-SVM classification method for EEG in brain-computer interfaces.

    Science.gov (United States)

    Yang, Banghua; Han, Zhijun; Zan, Peng; Wang, Qian

    2014-01-01

    Classification methods are a crucial direction in the current study of brain-computer interfaces (BCIs). To improve the classification accuracy for electroencephalogram (EEG) signals, a novel KF-PP-SVM (kernel fisher, posterior probability, and support vector machine) classification method is developed. Its detailed process entails the use of common spatial patterns to obtain features, based on which the within-class scatter is calculated. Then the scatter is added into the kernel function of a radial basis function to construct a new kernel function. This new kernel is integrated into the SVM to obtain a new classification model. Finally, the output of SVM is calculated based on posterior probability and the final recognition result is obtained. To evaluate the effectiveness of the proposed KF-PP-SVM method, EEG data collected from laboratory are processed with four different classification schemes (KF-PP-SVM, KF-SVM, PP-SVM, and SVM). The results showed that the overall average improvements arising from the use of the KF-PP-SVM scheme as opposed to KF-SVM, PP-SVM and SVM schemes are 2.49%, 5.83 % and 6.49 % respectively.

  9. Operational reliability of the GPK and the 4PP-2 heading machines

    Energy Technology Data Exchange (ETDEWEB)

    Ivanov, N.A.; Demchenko, N.T.

    1985-09-01

    Reliability of the GPK and 4PP-2 heading machines used in 98 development workings in 40 coal mines is analyzed. Failure analysis was based on records of 199 heading machines after overhauls. The mean-time-between-failures of the GPK and the 4PP-2 was 270 min (93 t) and 155 min (35 t), availability coefficient was 0.83 and 0.77 respectively. Reliability of the GPK on the average was higher than that of the 4PP-2. The mean-time-to-overhaul of the GPK was 17.7 months (54,000 t), of the 4PP-2 - 18 months (59,000 t). Time between overhauls in the case of the GPK was 14 months (47,200 t), in the case of the 4PP-2 it was 14.5 months (38,300 t). During the 17.7 months between overhauls the GPK failed 580 times, the repair operations lasted 530 h. During the 18 month time to overhaul the 4PP-2 failed 1600 times, the repair operations lasted 1300 h. Reliability of major elements of the 2 heading machines is analyzed: cutters, materials handling equipment, electrical equipment, hydraulic systems, dust suppression systems, etc.

  10. Associated strangeness production in pp collisions near threshold

    International Nuclear Information System (INIS)

    Winter, P.

    2004-01-01

    Motivated by the ongoing discussion concerning the nature of the scalar resonances f0(980) and a0(980), the COSY-11 collaboration has taken exclusive data on the ppppK+K- reaction near the production threshold. A first total cross section σ = (1.80 ± 0.27 -0.35 +0.28 ) nb for the excess energy Q = 17 MeV has been determined. In contrary to the η, ω, and η' single meson production studies which clearly show the strong pp final state interaction (FSI), the cross section values obtained at COSY-11 and DISTO can be both described by a fit with a four-body phase space including the proton-proton final state interaction as well as with one-meson exchange calculations neglecting FSI effects. Therefore, one might think about a compensation of the strong pp interaction through a pK-FSI effect or an additional degree of freedom caused by the four-body final state. In the latter case, strong FSI effects can be expected at Q-values very close to the K+K- production threshold. Such a motivation triggered - in combination with the investigation of the KK-bar interaction being relevant to the structure of the f0 (980) - further measurements at the excess energies Q = 10 and Q 28 MeV at COSY-11

  11. New horizons for (p)ppGpp in bacterial and plant physiology.

    Science.gov (United States)

    Braeken, Kristien; Moris, Martine; Daniels, Ruth; Vanderleyden, Jos; Michiels, Jan

    2006-01-01

    A hyperphosphorylated guanosine nucleotide, (p)ppGpp, was initially identified as the effector molecule responsible for the stringent response in Escherichia coli. However, a rapidly growing number of reports proves that (p)ppGpp-mediated regulation is conserved in many bacteria and even in plants. It is now clear that (p)ppGpp acts as a global regulator during physiological adaptation of the organism to a plethora of environmental conditions. Adaptation is not only essential for surviving periods of stress and nutrient exhaustion but also for the interaction of bacteria with their eukaryotic host, as observed during pathogenesis and symbiosis, and for bacterial multicellular behaviour. Recently, there have been several new discoveries about the effects of (p)ppGpp levels, balanced by RelA-SpoT homologue proteins, in diverse organisms.

  12. EPR Study of the Activation of Antioxidants in PP Irradiated with Gamma Rays

    International Nuclear Information System (INIS)

    Silva, P.

    2006-01-01

    The behavior of different formulations of Polypropylene (PP) with stabilizers such as buthyl-hydroxy-toluene (BHT), Chimasorb 944 (Hals) (CHIM), both from Ciba, and a copolymer of styrene-butadiene-styrene (SBS) were studied using electron paramagnetic resonance (EPR). In all the cases but the sample of PP-Hals, a characteristic specta for PP irradiated in air in the recently-irradiated condition was obtained. The lineshape of the signal was changed to that of a pure PP EPR signal as time elapsed and the alkyl radical concentration decreased up to its total disappearance. At that stage, the polyenil radical signal could be visualized better. The total free radical concentration decayed until approximately 800 hours in the PP-Hals and until around 2000 hours in all other cases. At those points, the total free radical concentrations began to increase in all the cases, except in the PP-BHT case. The lineshape was transformed into the lineshape of the Chimasorb radical in all the cases, except for the PP-BHT. In this last case, the EPR signal was not detectable. The BHT and the SBS diluted the free radical concentrations, being them smaller when they are present. The observed behavior in all the samples is consistent with the activation of the Chimasorb radical by gamma radiation

  13. Recent insights into Protein Phosphatase 2A structure and regulation: the reasons why PP2A is no longer considered as a lazy passive housekeeping enzyme

    Directory of Open Access Journals (Sweden)

    Martin, M.

    2010-01-01

    Full Text Available Although intracellular signal transduction is often portrayed as a protein kinase "domino effect", the counterbalancing function of phosphatases, and thus the control of phosphatase activity, is equally relevant to proper regulation of cellular function. Protein Phosphatase 2A (PP2A is a widely expressed family of protein phosphatases made of a core dimer, composed of a catalytic (C subunit and a structural (A subunit, in association with a third variable regulatory (B subunit. Although viewed as a constitutive housekeeping enzyme in the past, PP2A is a highly regulated phosphatase and is emerging as an important regulator of multiple cellular processes involving protein phosphorylation. The regulation of PP2A is mainly accomplished by the identity of the regulatory B-type subunit, which determines substrate specificity, subcellular localization and catalytic activity of the PP2A holoenzyme. In agreement with this, recent findings on the structure and post-translational modifications of PP2A emphasize the importance of PP2A holoenzyme composition in its regulation and pleiotropic activities.

  14. Placental Protein 13 (PP13 – a placental immunoregulatory galectin protecting pregnancy

    Directory of Open Access Journals (Sweden)

    Nandor Gabor Than

    2014-08-01

    Full Text Available Galectins are glycan-binding proteins that regulate innate and adaptive immune responses, and some confer maternal-fetal immune tolerance in eutherian mammals. A chromosome 19 cluster of galectins has emerged in anthropoid primates, species with deep placentation and long gestation. Three of the five human cluster galectins are solely expressed in the placenta, where they may confer additional immunoregulatory functions to enable deep placentation. One of these is galectin-13, also known as Placental Protein 13 (PP13. It has a jelly-roll fold, carbohydrate-recognition domain and sugar-binding preference resembling to other mammalian galectins. PP13 is predominantly expressed by the syncytiotrophoblast and released from the placenta into the maternal circulation. Its ability to induce apoptosis of activated T cells in vitro, and to divert and kill T cells as well as macrophages in the maternal decidua in situ suggests important immune functions. Indeed, mutations in the promoter and an exon of LGALS13 presumably leading to altered or non-functional protein expression are associated with a higher frequency of preeclampsia and other obstetrical syndromes, which involve immune dysregulation. Moreover, decreased placental expression of PP13 and its low first trimester maternal serum concentrations are associated with elevated risk of preeclampsia. Indeed, PP13 turned to be a good early biomarker to assess maternal risk for the subsequent development of pregnancy complications caused by impaired placentation. Due to the ischemic placental stress in preterm preeclampsia, there is an increased trophoblastic shedding of PP13 immunopositive microvesicles starting in the second trimester, which leads to high maternal blood PP13 concentrations. Our meta-analysis suggests that this phenomenon may enable the potential use of PP13 in directing patient management near to or at the time of delivery. Recent findings on the beneficial effects of PP13 on decreasing

  15. Slug-tests in PP- and PVP-holes at Olkiluoto in 2006

    International Nuclear Information System (INIS)

    Keskitalo, K.; Lindgren, S.

    2007-11-01

    As part of the program for the final disposal of the nuclear fuel waste, Posiva Oy investigates the hydrological conditions at the Olkiluoto island. The hydraulic conductivity in the shallow holes OL-PP5, OL-PP9, OL-PP36, OL-PP39, OL-PVP4A, OL-PVP4B, OL-PVP6A, OL-PVP6B and OL-PVP14 was measured in summer 2006. The length of PP-holes varies between 12 and 15 m, and the test sections (1 m) are located in the bedrock. PVP-tubes have a length up to 10 m, and the test sections (2 m) are located in the overburden. The measurements were done using the slug-test technique. In the slug-test, the hydraulic head in the borehole is abruptly changed either by pouring water into the borehole or by lowering the pressure sensor. The conductivity is interpreted based on the recovery of the water level. This report presents the field measurements and their interpretation. The interpretation has been done using the Hvorslev's method, and for reference, conductivity has also been calculated according to Thiem's equation. According to the results, hydraulic conductivity in PP-holes ranges from 10 -9 m/s to 10 -6 m/s and in PVP-tubes from 10 -8 m/s to 10 -5 m/s. The range is similar as observed in measurements of years 2002, 2004 and 2005. In general the results are consistent with the results obtained in earlier measurements. Some exceptions exist in OL-PP9, where the conductivity is lower than in the 2005 measurements, but still at the same level as in the 2002 measurements. Also, the results agree with hydraulic conductivity interpreted from the pre-pumping done in connection with the groundwater sampling. (orig.)

  16. Flame Retardancy and Mechanical Properties of Kenaf Filled Polypropylene (PP) Containing Ammonium Polyphosphate (APP)

    International Nuclear Information System (INIS)

    Atikah Ismail; Azman Hassan; Aznizam Abu Bakar; Jawaid, M.

    2013-01-01

    The effects of ammonium polyphosphate (APP) as flame retardant and kenaf as fillers on flammability, thermal and mechanical properties of polypropylene (PP) composites were determined. Test specimens were prepared by using a co-rotating twin screw extruder for the compounding process followed by injection molding. The flame retardancy of the composites was determined by using limiting oxygen index (LOI) test. Addition of flame retardant into kenaf-PP composites significantly increased the LOI values that indicated the improvement of flame retardancy. Thermogravimetric analysis was done to examine the thermal stability of the composites. The addition of kenaf fiber in PP composites decreased the thermal stability significantly but the influence of APP on thermal properties of the kenaf-filled PP composites was not significant. The flexural strength and modulus of composites increased with the addition of APP into kenaf filled PP composite. The addition of APP into kenaf filled PP causes increase in the impact strength while increasing the APP content in the kenaf filled PP composite show decrease in impact strength. (author)

  17. Small G proteins Rac1 and Ras regulate serine/threonine protein phosphatase 5 (PP5)·extracellular signal-regulated kinase (ERK) complexes involved in the feedback regulation of Raf1.

    Science.gov (United States)

    Mazalouskas, Matthew D; Godoy-Ruiz, Raquel; Weber, David J; Zimmer, Danna B; Honkanen, Richard E; Wadzinski, Brian E

    2014-02-14

    Serine/threonine protein phosphatase 5 (PP5, PPP5C) is known to interact with the chaperonin heat shock protein 90 (HSP90) and is involved in the regulation of multiple cellular signaling cascades that control diverse cellular processes, such as cell growth, differentiation, proliferation, motility, and apoptosis. Here, we identify PP5 in stable complexes with extracellular signal-regulated kinases (ERKs). Studies using mutant proteins reveal that the formation of PP5·ERK1 and PP5·ERK2 complexes partially depends on HSP90 binding to PP5 but does not require PP5 or ERK1/2 activity. However, PP5 and ERK activity regulates the phosphorylation state of Raf1 kinase, an upstream activator of ERK signaling. Whereas expression of constitutively active Rac1 promotes the assembly of PP5·ERK1/2 complexes, acute activation of ERK1/2 fails to influence the phosphatase-kinase interaction. Introduction of oncogenic HRas (HRas(V12)) has no effect on PP5-ERK1 binding but selectively decreases the interaction of PP5 with ERK2, in a manner that is independent of PP5 and MAPK/ERK kinase (MEK) activity, yet paradoxically requires ERK2 activity. Additional studies conducted with oncogenic variants of KRas4B reveal that KRas(L61), but not KRas(V12), also decreases the PP5-ERK2 interaction. The expression of wild type HRas or KRas proteins fails to reduce PP5-ERK2 binding, indicating that the effect is specific to HRas(V12) and KRas(L61) gain-of-function mutations. These findings reveal a novel, differential responsiveness of PP5-ERK1 and PP5-ERK2 interactions to select oncogenic Ras variants and also support a role for PP5·ERK complexes in regulating the feedback phosphorylation of PP5-associated Raf1.

  18. The reaction np→ pp π- from threshold up to 570 MeV

    International Nuclear Information System (INIS)

    Daum, M.; Finger, M.; Slunecka, M.; Finger, M. Jr.; Janata, A.; Franz, J.; Heinsius, F.H.; Koenigsmann, K.; Lacker, H.; Schmitt, H.; Schweiger, W.; Sereni, P.

    2002-01-01

    The reaction np→ppπ - has been studied in a kinematically complete measurement with a large acceptance time-of-flight spectrometer for incident neutron energies between threshold and 570 MeV. The proton-proton invariant mass distributions show a strong enhancement due to the pp( 1 S 0 ) final state interaction. A large anisotropy was found in the pion angular distributions in contrast to the reaction pp→ppπ 0 . At small energies, a large forward/backward asymmetry has been observed. From the measured integrated cross section σ(np→ppπ - ), the isoscalar cross section σ 01 has been extracted. Its energy dependence indicates that mainly partial waves with Sp final states contribute. (orig.)

  19. Charmed hadron production in pp collision

    Science.gov (United States)

    Goswami, Umananda Dev

    2007-10-01

    We investigated the production of charmed hadrons ( D+, D-, D0, D, Λc+, Λ¯c-) in pp collisions as a function of √{s}, xF, p⊥2 and p⊥ in the framework of the QGSJET model. The study of charmed hadron production characteristics in pp collision is particularly important for cosmic ray physics in the context of atmospheric prompt lepton fluxes. Here our aim is to check the reliability of the QGSJET model to be used to study the production of charmed hadrons in cosmic ray hadronic interactions with air nuclei. Charmed hadroproduction cross sections or the charmed hadron average multiplicities in pp collisions are relatively very small. The maximum production of all charmed hadrons takes place with low values of xF, p⊥2, and p⊥ within a small range for all values of √{s} under study. Charmed hadroproduction cross sections as a function of xF and p⊥2 are compared with the LEBC-EHS and LEBC-MPS experiment data for D-meson production. The agreement is quite satisfactory for smaller values of p⊥2 (⩽2 (GeV/c) 2). There is an asymmetry in charmed hadroproduction in pp collision. For all xF, asymmetry is prominent in the low value of √{s}. There is a strong preference for producing Λc+ rather than Λ¯c-baryons, while that for producing D¯ rather than D-mesons for this range of √{s}. Asymmetry increases from zero to ±1 around xF = 0.3 for all values of √{s} and for all charmed hardron groups. The patterns of asymmetric production of different charmed hadrons with xF are approximately the same as that with √{s}. We compare our calculation with the data from Fermilab experiment E781 (SELEX) for Λc-baryon production. The agreement is quite good. The asymmetry of charmed hadroproduction with p⊥ does not follow any well defined pattern.

  20. Liver carbohydrates metabolism: A new islet-neogenesis associated protein peptide (INGAP-PP) target.

    Science.gov (United States)

    Villagarcía, Hernán Gonzalo; Román, Carolina Lisi; Castro, María Cecilia; González, Luisa Arbeláez; Ronco, María Teresa; Francés, Daniel Eleazar; Massa, María Laura; Maiztegui, Bárbara; Flores, Luis Emilio; Gagliardino, Juan José; Francini, Flavio

    2018-03-01

    Islet-Neogenesis Associated Protein-Pentadecapeptide (INGAP-PP) increases β-cell mass and enhances glucose and amino acids-induced insulin secretion. Our aim was to demonstrate its effect on liver metabolism. For that purpose, adult male Wistar rats were injected twice-daily (10 days) with saline solution or INGAP-PP (250 μg). Thereafter, serum glucose, triglyceride and insulin levels were measured and homeostasis model assessment (HOMA-IR) and hepatic insulin sensitivity (HIS) were determined. Liver glucokinase and glucose-6-phosphatase (G-6-Pase) expression and activity, phosphoenolpyruvate carboxykinase (PEPCK) expression, phosphofructokinase-2 (PFK-2) protein content, P-Akt/Akt and glycogen synthase kinase-3β (P-GSK3/GSK3) protein ratios and glycogen deposit were also determined. Additionally, glucokinase activity and G-6-Pase and PEPCK gene expression were also determined in isolated hepatocytes from normal rats incubated with INGAP-PP (5 μg/ml). INGAP-PP administration did not modify any of the serum parameters tested but significantly increased activity of liver glucokinase and the protein level of its cytosolic activator, PFK-2. Conversely, INGAP-PP treated rats decreased gene expression and enzyme activity of gluconeogenic enzymes, G-6-Pase and PEPCK. They also showed a higher glycogen deposit and P-GSK3/GSK3 and P-Akt/Akt ratio. In isolated hepatocytes, INGAP-PP increased GK activity and decreased G-6-Pase and PEPCK expression. These results demonstrate a direct effect of INGAP-PP on the liver acting through P-Akt signaling pathway. INGAP-PP enhances liver glucose metabolism and deposit and reduces its production/output, thereby contributing to maintain normal glucose homeostasis. These results reinforce the concept that INGAP-PP might become a useful tool to treat people with impaired islet/liver glucose metabolism as it occurs in T2D. Copyright © 2018 Elsevier Inc. All rights reserved.

  1. Surface/state correspondence and bulk local operators in pp-wave holography

    Directory of Open Access Journals (Sweden)

    Nakwoo Kim

    2015-12-01

    Full Text Available We apply the surface/state correspondence proposal of Miyaji et al. to IIB pp-waves and propose that the bulk local operators should be instantonic D-branes. In line with ordinary AdS/CFT correspondence, the bulk local operators in pp-waves also create a hole, or a boundary, in the dual gauge theory as pointed out by H. Verlinde, and by Y. Nakayama and H. Ooguri. We also present simple calculations which illustrate how to extract the spacetime metric of pp-waves from instantonic D-branes in boundary state formalism.

  2. Study of PP/montmorillonite composite degradation

    International Nuclear Information System (INIS)

    Baer, Marcia; Granado, Carlos J.F.

    2009-01-01

    The objective of this work was to produce composites of PP/sodium bentonite and PP/ organophilic bentonite through melt intercalation and analyze the degradation produced by ultraviolet irradiation. The XRD results showed that the samples of nature bentonite had better interaction with de polymer and produced intercalated nanocomposite. The effect of UV irradiation on degradation was observed after 24 hours of exposition. The samples showed the same photoproducts and at the same proportion until 240 hours of UV exposition; with 480 hours the organophilize bentonite composite showed higher degradation than other ones. The superficial cracks increased with degradation time. The degradation occurs due chromophores impurities presented in the samples, thus samples with sodium clay show higher degradation, and organophilic clay contains ammonium salt that contribute to increase the degradation. (author)

  3. PpHB22, a member of HD-Zip proteins, activates PpDAM1 to regulate bud dormancy transition in 'Suli' pear (Pyrus pyrifolia White Pear Group).

    Science.gov (United States)

    Yang, Qinsong; Niu, Qingfeng; Li, Jianzhao; Zheng, Xiaoyan; Ma, Yunjing; Bai, Songling; Teng, Yuanwen

    2018-06-01

    Homeodomain-leucine zipper (HD-Zip) proteins, which form one of the largest and most diverse families, regulate many biological processes in plants, including differentiation, flowering, vascular development, and stress signaling. Abscisic acid (ABA) has been proved to be one of the key regulators of bud dormancy and to influence several HD-Zip genes expression. However, the role of HD-Zip genes in regulating bud dormancy remains unclear. We identified 47 pear (P. pyrifolia White Pear Group) HD-Zip genes, which were classified into four subfamilies (HD-Zip I-IV). We further revealed that gene expression levels of some HD-Zip members were closely related to ABA concentrations in flower buds during dormancy transition. Exogenous ABA treatment confirmed that PpHB22 and several other HD-Zip genes responded to ABA. Yeast one-hybrid and dual luciferase assay results combining subcellular localization showed that PpHB22 was present in nucleus and directly induced PpDAM1 (dormancy associated MADS-box 1) expression. Thus, PpHB22 is a negative regulator of plant growth associated with the ABA response pathway and functions upstream of PpDAM1. These findings enrich our understanding of the function of HD-Zip genes related to the bud dormancy transition. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

  4. pp-waves in 11-dimensions

    International Nuclear Information System (INIS)

    Gauntlett, Jerome P.; Hull, Christopher M.

    2002-01-01

    The Killing spinor equations for pp-wave solutions of eleven dimensional supergravity are analysed and it is shown that there are solutions that preserve 18, 20, 22 and 24 supersymmetries, in addition to the generic solution preserving 16 supersymmetries and the Kowalski-Glikman solution preserving 32 supersymmetries. (author)

  5. Nanoparticles dispersion in processing functionalised PP/TiO2 nanocomposites: distribution and properties

    International Nuclear Information System (INIS)

    El-Dessouky, Hassan M.; Lawrence, Carl A.

    2011-01-01

    Future innovations in textiles and fibrous materials are likely to demand fibres with enhanced multifunctionality. The fibres can be functionalized by dispersing nanoadditives into the polymer during melt compounding/spinning. TiO 2 nanoparticles have the potential to improve UV resistance, antistatic, as well as impart self-cleaning by photocatalysis and thereby de-odour and antimicrobial effects. In this study, a micro-lab twin-screw extruder was used to produce samples of polypropylene (PP) nanocomposite monofilaments, doped with nano titanium oxide (TiO 2 )/manganese oxide (MnO) compound having size ranging from 60 to 200 nm. As a control sample, PP filaments without additives were also extruded. Three samples were produced containing different concentrations (wt%) of the TiO 2 compound, i.e. 0.95, 1.24 and 1.79%. Nano metal-oxide distribution in the as-spun and drawn nanocomposite filaments was analysed. Although, there are small clusters of the nanoparticles, the characterizing techniques showed good dispersion and distribution of the modified TiO 2 along and across the processed filaments. From UV spectroscopy and TGA, a significant enhancement of polypropylene UV protection and thermal stability were observed: PP with higher percentage of TiO 2 absorbed UV wavelength of 387 nm and thermally decomposed at 320.16 °C accompanied by 95% weight loss.

  6. Analysis of forward and near-forward elastic-scattering amplitudes for pp and anti pp collisions

    International Nuclear Information System (INIS)

    Block, M.B.; Cahn, R.N.

    1983-04-01

    We will present the results of two recently published (1983) papers by M.M. Block and R.N. Cahn, which analyze for anti pp and pp elastic scattering the rho values (ratios of the real to the imaginary parts of the forward nuclear scattering amplitudes), the total (hadronic) cross sections sigma, and the b values, the nuclear slope parameters. The predictions of the analyses, from √ s bar > 5 GeV, is compared with the recently measured values of sigma and b at the SPS Collider. The analysis has also been redone to include new ISR data available from R211 at √ s bar = 62.5 GeV, in order to estimate odderon contributions, i.e., contributions from odd amplitudes with unconventional (non-Reggeon) energy dependence. Limits of approx. 1% are placed on these amplitudes. Our analysis has been extrapolated up to 100 TeV, to give sigma, rho and b predictions for cosmic ray and future collider energies

  7. Reversal of fragile X phenotypes by manipulation of AβPP/Aβ levels in Fmr1KO mice.

    Directory of Open Access Journals (Sweden)

    Cara J Westmark

    Full Text Available Fragile X syndrome (FXS is the most common form of inherited intellectual disability and the leading known genetic cause of autism. Fragile X mental retardation protein (FMRP, which is absent or expressed at substantially reduced levels in FXS, binds to and controls the postsynaptic translation of amyloid β-protein precursor (AβPP mRNA. Cleavage of AβPP can produce β-amyloid (Aβ, a 39-43 amino acid peptide mis-expressed in Alzheimer's disease (AD and Down syndrome (DS. Aβ is over-expressed in the brain of Fmr1(KO mice, suggesting a pathogenic role in FXS. To determine if genetic reduction of AβPP/Aβ rescues characteristic FXS phenotypes, we assessed audiogenic seizures (AGS, anxiety, the ratio of mature versus immature dendritic spines and metabotropic glutamate receptor (mGluR-mediated long-term depression (LTD in Fmr1(KO mice after removal of one App allele. All of these phenotypes were partially or completely reverted to normal. Plasma Aβ(1-42 was significantly reduced in full-mutation FXS males compared to age-matched controls while cortical and hippocampal levels were somewhat increased, suggesting that Aβ is sequestered in the brain. Evolving therapies directed at reducing Aβ in AD may be applicable to FXS and Aβ may serve as a plasma-based biomarker to facilitate disease diagnosis or assess therapeutic efficacy.

  8. Characterization of cDNA encoding human placental anticoagulant protein (PP4): Homology with the lipocortin family

    International Nuclear Information System (INIS)

    Grundmann, U.; Abel, K.J.; Bohn, H.; Loebermann, H.; Lottspeich, F.; Kuepper, H.

    1988-01-01

    A cDNA library prepared from human placenta was screened for sequences encoding the placental protein 4 (PP4). PP4 is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Partial amino acid sequence information from PP4-derived cyanogen bromide fragments was used to design three oligonucleotide probes for screening the library. From 10 6 independent recombinants, 18 clones were identified that hybridized to all three probes. These 18 recombinants contained cDNA inserts encoding a protein of 320 amino acid residues. In addition to the PP4 cDNA the authors identified 9 other recombinants encoding a protein with considerable similarity (74%) to PP4, which was termed PP4-X. PP4 and PP4-X belong to the lipocortin family, as judged by their homology to lipocortin I and calpactin I

  9. ATLAS b-tagging efficiency measurements using a $t\\bar{t}$ sample in pp collisions at $\\sqrt s$=13 TeV

    CERN Document Server

    Li, Changqiao; The ATLAS collaboration

    2017-01-01

    The $b$-tagging efficiency of the MV2c10 discriminant for track-jets and calorimeter-jets containing $b$-hadrons is measured using 36.5~fb$^{-1}$ of $pp$ collisions collected in 2015 and 2016 by ATLAS at $\\sqrt{s}$=13~TeV. The measurements are performed using a tag-and-probe method to select a control sample of jets enriched in $b$-jets, by keeping events with a final state consistent with the process $pp\\to t\\bar{t}\\to W^+bW^-\\bar{b} \\to e^\\pm \\mu^\\mp \

  10. Nanocomposites of PP and bentonite clay modified with different surfactants

    International Nuclear Information System (INIS)

    Rodrigues, Andre W.B.; Agrawal, Pankaj; Araujo, Edcleide M.; Melo, Tomas J.A.; Ueki, Marcelo M.

    2009-01-01

    The aim of this work was the development of nano composites of polypropylene (PP) and national bentonite clay modified with different surfactants. The results of X-Ray diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR) showed that the organophilization process was effective. The surfactants led to a significant increase in the basal spacing of Brasgel PA clay. XRD results of the mixture PP/Brasgel PA clay modified with Praepagem WB surfactant indicated that a nanocomposite with intercalated structure was formed. When the Brasgel PA clay was modified with Praepagem HY surfactant, DRX results indicated that a micro composite was formed. Screw speed, clay content and PP viscosity had no influence on the XRD pattern of the obtained materials. (author)

  11. An anti-bacterial approach to nanoscale roughening of biomimetic rice-like pattern PP by thermal annealing

    Science.gov (United States)

    Jafari Nodoushan, Emad; Ebrahimi, Nadereh Golshan; Ayazi, Masoumeh

    2017-11-01

    In this paper, we introduced thermal annealing treatment as an effective way of increasing the nanoscale roughness of a semi-crystalline polymer surface. Annealing treatment applied to a biomimetic microscale pattern of rice leaf to achieve a superhydrophobic surface with a hierarchical roughness. Resulted surfaces was characterized by XRD, AFM and FE-SEM instruments and showed an increase of roughness and cristallinity within both time and temperature of treatment. These two parameters also impact on measured static contact angle up to 158°. Bacterial attachment potency has an inverse relationship with the similarity of surface pattern dimensions and bacterial size and due to that, thermal annealing could be an effective way to create anti-bacterial surface beyond its effect on water repellency. Point in case, the anti-bacterial properties of produced water-repellence surfaces of PP were measured and counted colonies of both gram-negative (E. coli) and gram-positive (S. aureus) bacteria reduced with the nature of PP and hierarchical pattern on that. Anti-bacterial characterization of the resulted surface reveals a stunning reduction in adhesion of gram-positive bacteria to the surface. S. aureus reduction rates equaled to 95% and 66% when compared to control blank plate and smooth surface of PP. Moreover, it also could affect the other type of bacteria, gram-negative (E. coli). In the latter case, adhesion reduction rates calculated 66% and 53% when against to the same controls, respectively.

  12. Groundwater sampling from shallow boreholes (PP and PR) and groundwater observation tubes (PVP) at Olkiluoto in 2004

    Energy Technology Data Exchange (ETDEWEB)

    Hirvonen, H. [Teollisuuden Voima Oyj, Eurajoki (Finland)

    2005-11-15

    Groundwater sampling from the shallow boreholes and groundwater observation tubes was performed in summer 2004 (PP2, PP3, PP7, PP8, PRl, PVPl, PVP3A, PVP3B, PVP4A and PVP4B) and in autumn 2004 (PP2, PP3, PP5, PP7, PP8, PP9, PP36, PP37, PP39, PR1, PR2, PVP1, PVP3A, PVP3B, PVP4A, PVP8A, PVP9A, PVP9B, PVP10B, PVP11, PVP12, PVP13, PVP14 and PVP20). The results from previous samplings have been used in the hydrogeochemical baseline characterization at Olkiluoto and some of the latest results have also been part of the ONKALO monitoring program. This study contains data on preliminary pumping of the sampling points and pumping for groundwater sampling and chemical analyses in the laboratory. This study also includes comparison with analytical results obtained between 1995-2004. The total dissolved solids (TDS) of groundwater samples were mainly below 1000 mg/L. According to Davis's TDS classification, these waters were fresh waters. The only exception was the water sample from shallow borehole PP7 (1400mg/L and 1450mg/L), which was brackish. Several different groundwater types were observed, but the most common water type was Ca-HCO{sub 3} (five samples). Analytical results from 1995-2003 were compared. During 2001-2003 in groundwater samples from sampling points PVP1, PVP9A and PP7 all measured main parameters changed considerably, but from summer 2003 to autumn 2004 the greatest alterations occurred in PR2, PVP1, PVP3A and PVP3B waters. These changes can be seen in almost all parameters. For other samples only minor changes in results were observed during the reference period. (orig.)

  13. Lessons Learned from PR and PP Case Study

    Energy Technology Data Exchange (ETDEWEB)

    Bley, D.C. [Buttonwood Consulting, Inc., 11738 English Mill Court, Oakton, VA 22124 (United States)

    2009-06-15

    The Generation-IV International Forum (GIF) working group on proliferation resistance and physical protection (PR and PP) has developed a methodology for evaluating the PR and PP effectiveness of Gen-IV nuclear energy systems. A number of applications studies culminating in the 2008-2009 Case Study have been helpful in developing the methodology, and in testing its ease of use and ability to provide useful information to designers and policy/decision makers. This paper examines the lessons learned from these studies. The applications studies evaluated a set of PR and PP measures for an 'Example Sodium Fast Reactor' (ESFR), a hypothetical design incorporating many features of anticipated Gen-IV energy systems. The objectives of the 2008- 2009 Case Study were to exercise the GIF PR and PP Methodology for a complete Gen-IV reactor/fuel cycle system; to demonstrate, via the comparison of different design options, that the methodology can generate meaningful results for designers and decision makers; to provide examples of PR and PP evaluations for future users; to facilitate transition to other studies; and to facilitate other ongoing collaborative efforts (e.g., INPRO) and associated efforts (e.g., GNEP). We will explain how the Case Study met these goals. PR Lessons Learned. We found that completeness in 'diversion' pathways can be ensured and that a set of diversion pathway segments can be developed along with proliferation resistance measures for each pathway. The examination of 'misuse' found that misuse, for achieving weapons-usable fissile material, is a complex process, i.e., it is not a single action on a single piece of equipment, but rather an integrated exploitation of various assets and system elements. We found that 'breakout' is a modifying strategy within the diversion and misuse threats and takes various forms that depend upon intent and aggressiveness, and ultimately the proliferation time assumed by a

  14. Parity-Time Symmetry and the Toy Models of Gain-Loss Dynamics near the Real Kato's Exceptional Points

    Czech Academy of Sciences Publication Activity Database

    Znojil, Miloslav

    2016-01-01

    Roč. 8, č. 6 (2016), s. 52 ISSN 2073-8994 R&D Projects: GA ČR GA16-22945S Institutional support: RVO:61389005 Keywords : parity-time symmetry * Schrodinger equation * physical Hilbert space * inner-product metric operator * real exceptional points * solvable models * quantum Big Bang * quantum Inflation period Subject RIV: BE - Theoretical Physics Impact factor: 1.457, year: 2016

  15. Tailored sPP/Silica Nano composite for Eco friendly Insulation of Extruded HVDC Cable

    International Nuclear Information System (INIS)

    Dang, B.; He, J.; Hu, J.; Zhou, Y.

    2015-01-01

    Cross-linked polyethylene (XLPE) is a thermosetting material that cannot be recycled at the end of its lifetime. This study investigated the potential of syndiotactic polypropylene (sPP)/silica as an eco friendly extruded insulation system for HVDC cables. We investigated the morphology, Fourier transform infrared, and thermal, thermomechanical, and electrical behaviors of sPP modified with 0.5-3% nano silica. We found that the silica/sPP nano composite without cross-linking offered a suitable mechanical modulus at room temperature and sufficient intensity at high temperatures, and adding nano silica modified by a silane coupling agent to the sPP resulted in significant DC resistivity and space charge improvement. The optimal nano silica content in the sPP was determined by balancing the mechanical and thermomechanical characteristics and the DC resistivity. The sPP/silica nano composite reported here shows great potential as a candidate insulation material for future eco friendly extruded HVDC cables.

  16. Imaging the proton via hard exclusive production in diffractive pp scattering

    International Nuclear Information System (INIS)

    Charles Hyde; Leonid Frankfurt; Mark Strikman; Christian Weiss

    2007-01-01

    We discuss the prospects for probing Generalized Parton Distributions (GPDs) via exclusive production of a high-mass system (H = heavy quarkonium, di-photon, di-jet, Higgs boson) in diffractive pp scattering, pp -> p + H + p. In such processes the interplay of hard and soft interactions gives rise to a diffraction pattern in the final-state proton transverse momenta, which is sensitive to the transverse spatial distribution of partons in the colliding protons. We comment on the plans for diffractive pp measurements at RHIC and LHC. Such studies could complement future measurements of GPDs in hard exclusive ep scattering (JLab, COMPASS, EIC)

  17. Tip-over Prevention: Adaptive Control Development

    Science.gov (United States)

    2015-05-30

    Tip-over Prevention: Adaptive Control Development Leah Kelley Massachusetts Institute of Technology Cambridge, MA 02139 Email: lckelley@mit.edu Kurt...Papadopoulos and D. Rey, Proc. IEEE ICRA, vol.4, 1996, pp. 3111. [7] S. Ali, A. Moosavian, and K. Alipour, Robotics, Automation and Mechatronics , 2006 IEEE Conf...on, 2006, pp. 1–6. [8] K. Talke, L. Kelley, P. Longhini, and G. Catron, Proc. SPIE 9084, Unmanned Systems Technology XVI, June 2014, pp. 90 840L–11

  18. Peripheral administration of antisense oligonucleotides targeting the amyloid-β protein precursor reverses AβPP and LRP-1 overexpression in the aged SAMP8 mouse brain.

    Science.gov (United States)

    Erickson, Michelle A; Niehoff, Michael L; Farr, Susan A; Morley, John E; Dillman, Lucy A; Lynch, Kristin M; Banks, William A

    2012-01-01

    The senescence accelerated mouse-prone 8 (SAMP8) mouse model of Alzheimer's disease has a natural mutation leading to age-related increases in the amyloid-β protein precursor (AβPP) and amyloid-β (Aβ) in the brain, memory impairment, and deficits in Aβ removal from the brain. Previous studies show that centrally administered antisense oligonucleotide directed against AβPP can decrease AβPP expression and Aβ production in the brains of aged SAMP8 mice, and improve memory. The same antisense crosses the blood-brain barrier and reverses memory deficits when injected intravenously. Here, we give 6 μg of AβPP or control antisense 3 times over 2 week intervals to 12 month old SAMP8 mice. Object recognition test was done 48 hours later, followed by removal of whole brains for immunoblot analysis of AβPP, low-density lipoprotein-related protein-1 (LRP-1), p-glycoprotein (Pgp), receptor for advanced glycation endproducts (RAGE), or ELISA of soluble Aβ(40). Our results show that AβPP antisense completely reverses a 30% age-associated increase in AβPP signal (p < 0.05 versus untreated 4 month old SAMP8). Soluble Aβ(40) increased with age, but was not reversed by antisense. LRP-1 large and small subunits increased significantly with age (147.7%, p < 0.01 and 123.7%, p < 0.05 respectively), and AβPP antisense completely reversed these increases (p < 0.05). Pgp and RAGE were not significantly altered with age or antisense. Antisense also caused improvements in memory (p < 0.001). Together, these data support the therapeutic potential of AβPP antisense and show a unique association between AβPP and LRP-1 expression in the SAMP8 mouse.

  19. Polarized proton parameters for the 2015 PP-on-Au setup in RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Gardner, C. J. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-08-25

    Values are given for RHIC circumference shifts due to snakes for various situations. Relevant parameters are tabulated for polarized protons (PP) in the booster and in AGS and RHIC for PP-on-Au stores.

  20. Polarized proton parameters for the 2015 PP-on-Aluminum setup in RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Gardner, C. J. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-10-02

    Values are given for RHIC circumference shifts due to snakes for various situations. Relevant parameters are tabulated for polarized protons (PP) in the booster and in AGS and RHIC for PP-on-Aluminum stores.

  1. pp waves of conformal gravity with self-interacting source

    International Nuclear Information System (INIS)

    Ayon-Beato, Eloy; Hassaine, Mokhtar

    2005-01-01

    Recently, Deser, Jackiw and Pi have shown that three-dimensional conformal gravity with a source given by a conformally coupled scalar field admits pp wave solutions. In this paper, we consider this model with a self-interacting potential preserving the conformal structure. A pp wave geometry is also supported by this system and, we show that this model is equivalent to topologically massive gravity with a cosmological constant whose value is given in terms of the potential strength

  2. Investigation on γ-irradiated PP/ethylene acrylic elastomer TPVs by rheological and thermal approaches

    Science.gov (United States)

    Dutta, Anindya; Ghosh, Anup K.

    2018-03-01

    Polypropylene (PP) was melt blended with varying concentration of ethylene acrylic elastomer (AEM) in a twin screw extruder and then γ-irradiated at several radiation doses to achieve a series of thermoplastic vulcanizates (TPV). The effect of AEM concentration and γ-irradiation on flow characteristics, crystallization and thermal degradation of blends were explained using melt dynamic rheology, differential scanning calorimetry and thermogravimetric analysis. Gel content values and dynamic rheological data of PP and AEM at different radiation doses confirmed the incessant scissioning of PP chains with radiation doses except for highest radiation dose, where crosslinking of PP chains took place and the incessant crosslinking of AEM chains irrespective of radiation doses. Oxidative degradation of PP was confirmed by FTIR spectroscopy, which also exhibited absence of any chemical interaction between two constituent polymers. Normalized crystallinity and melting point of compositions, obtained from DSC, decreased with the radiation doses. Furthermore, with the radiation doses clear shifts of maxima of the melting peak towards the lower temperature were observed for neat PP and blends. Thermal stability of PP and blends, as observed by TGA, reduced significantly with irradiation; whereas for AEM, no discernable change was observed. Enhanced chain scissioning of PP in presence of AEM reduced the thermal stability of blends, especially at lower irradiation. This reduction of thermal stability was established by "rule of mixture", applied to the activation energy of thermal degradation. Thus, optimization of radiation doses to prepare TPVs was established.

  3. Biodegradação de filmes de PP/PCL em solo e solo com chorume Study of biodegradation of PP/PCL films in soil and soil with leachate landfill

    Directory of Open Access Journals (Sweden)

    Adriana de Campos

    2010-01-01

    Full Text Available Filmes de blenda de poli(ε-caprolactona (PCL e polipropileno (PP foram obtidos por moldagem por compressão. O estudo da biodegradação de filmes de blendas de PP/PCL em solo e solo com chorume foi obtido pela evolução de CO2, perda de massa, ângulo de contato, microscopia eletrônica de varredura (MEV e calorimetria exploratória diferencial (DSC. As análises de evolução de CO2 mostraram que a biodegradação da blenda de PP/PCL em solo com chorume foi maior que a dos homopolímeros, sugerindo que os polímeros na blenda são mais suscetíveis à degradação, o que se deve à não interação entre PP e PCL. Os resultados também mostraram que os microrganismos do solo com chorume provocaram uma erosão superficial. Verificou-se que a biodegradação do PCL é inibida pelos microrganismos do chorume adicionados no solo.Blend films of polycaprolactone (PCL and polypropylene (PP have been obtained by melt-pressing of both components. The biodegradation of PP/PCL blend films in soil and soil with leachate landfill has been assessed with measurements of evolution of CO2, weight loss, contact angle, scanning electronic microscopy (SEM and differential scanning calorimetry (DSC. The respirometric tests showed that the PP/PCL biodegradation in the soil with leachate was higher than the homopolymers, suggesting that the polymers in the blend are more susceptible to biodegradation owing to the lack of interaction between PP and PCL. The results also showed that biodegradation due to microorganisms in the soil with leachate occurred by surface erosion. It was found that the PCL biodegradation is inhibited by the leachate microorganisms added in the soil.

  4. BOEKBESPREKINGS P.P. BOOK REVIEWS

    African Journals Online (AJOL)

    LOCAL ANAESTHESIA. Physiology and Pharmacology oj Local Anesthesia. By R. H. de Jong, M.D. Pp. xiv + 267. Illustrated. $12.50. Spring- field, Ill.: Charles C. Thomas. 1970. This book fills a gap in anaesthetic literature. It is written in lucid style, with ideas logically, if repetitively developed with clear figures and useful ...

  5. Relations between a novel, reliable, and rapid index of arterial compliance (PP-HDI) and well-established inidices of arterial blood pressure (ABP) in a sample of hypertensive elderly subjects.

    Science.gov (United States)

    Bergamini, L; Finelli, M E; Bendini, C; Ferrari, E; Veschi, M; Neviani, F; Manni, B; Pelosi, A; Rioli, G; Neri, M

    2009-01-01

    Hypertension is a risk factor for a long-lasting arterial wall-remodelling leading to stiffness. The rapid method measuring the pulse pressure (PP) by means of the tool of Hypertension Diagnostic Instruments (HDI) called PP-HDI, overcomes some of the problems arising with more-time consuming methods, like ambulatory blood pressure monitoring (ABPM), and give information about the elasticity of the arterial walls. We studied the relationship between the PP-HDI, the large artery compliance (LA-C) and small artery compliance (SA-C) and few well-established indices of arterial blood pressure (ABP) in a sample of 75 hypertensive subjects, aged 65 years and over. Significant correlations between LA-C and heart rate (HR), PP-ABPM and PP-HDI were found. SA-C relates with HR and systolic blood pressure (SBP) measured in lying and standing positions. Applying a stepwise regression analysis, we found that LA-C variance stems from PP-HDI and HR, while SA-C variance stems from SBP in lying position. Receiver operator characteristic (ROC) curves for thresholds of PP showed that PP-HDI reached levels of sensitivity/specificity similar to PP-ABPM. In conclusion, surveillance of ABP through hemo-dynamic indices, in particular of SBP, is essential, nevertheless the advantage of this control is not known in an elderly population where the organ damage is already evident. PP needs necessarily an instrumental measurement. The PP-HDI result is similar in reliability with respect to PPABPM, but is more rapid and well applicable in an elderly population.

  6. Control Strategies for Guided Collective Motion

    Science.gov (United States)

    2015-02-27

    J.K. Parrish , “Oscillator models and collective motion,” IEEE Control Systems Magzine, Vol. 27, 2007, pp. 89-105. [18] S. H. Strogatz , “From Kuramoto...Automatic Control, 54(2), 2009, pp. 353-357. [21] H. Hong and S. H. Strogatz , “Kuramoto Model of Coupled Oscillators with Positive and Negative...2013) provided similar results by utilizing a modified Kuramoto model ( Strogatz (2000)). Paley (2008) proposed a Lyapunov-based design methodology to

  7. PP4 is essential for germinal center formation and class switch recombination in mice.

    Directory of Open Access Journals (Sweden)

    Ming-Yu Chen

    Full Text Available PP4 is a serine/threonine phosphatase required for immunoglobulin (Ig VDJ recombination and pro-B/pre-B cell development in mice. To elucidate the role of PP4 in mature B cells, we ablated the catalytic subunit of murine PP4 in vivo utilizing the CD23 promoter and cre-loxP recombination and generated CD23(crePP4(F/F mice. The development of follicular and marginal zone B cells was unaffected in these mutants, but the proliferation of mature PP4-deficient B cells stimulated by in vitro treatment with either anti-IgM antibody (Ab or LPS was partially impaired. Interestingly, the induction of CD80 and CD86 expression on these stimulated B cells was normal. Basal levels of serum Igs of all isotypes were strongly reduced in CD23(crePP4(F/F mice, and their B cells showed a reduced efficiency of class switch recombination (CSR in vitro upon stimulation by LPS or LPS plus IL-4. When CD23(crePP4(F/F mice were challenged with either the T cell-dependent antigen TNP-KLH or the T cell-independent antigen TNP-Ficoll, or by H1N1 virus infection, the mutant animals failed to form germinal centers (GCs in the spleen and the draining mediastinal lymph nodes, and did not efficiently mount antigen-specific humoral responses. In the resting state, PP4-deficient B cells exhibited pre-existing DNA fragmentation. Upon stimulation by DNA-damaging drug etoposide in vitro, mutant B cells showed increased cleavage of caspase 3. In addition, the mutant B cells displayed impaired CD40-mediated MAPK activation, abnormal IgM-mediated NF-κB activation, and reduced S phase entry upon IgM/CD40-stimulation. Taken together, our results establish a novel role for PP4 in CSR, and reveal crucial functions for PP4 in the maintenance of genomic stability, GC formation, and B cell-mediated immune responses.

  8. Development of Novel ECTFE Coated PP Composite Hollow-Fiber Membranes

    Directory of Open Access Journals (Sweden)

    Sergio Santoro

    2016-09-01

    Full Text Available In this work composite hollow-fibers were prepared by dip-coating of commercial polypropylene (PP with a thin layer of ethylene–chlorotrifluoroethylene copolymer (ECTFE. The employment of N-methyl pyrrolidone (NMP as solvent improved the polymer processability favoring dip-coating at lower temperature (135 °C. Scanning electron microscopy (SEM analyses showed that after dip-coating the PP support maintained its microstructure, whereas a thin coated layer of ECTFE on the external surface of the PP hollow-fiber was clearly distinguishable. Membrane characterization evidenced the effects of the concentration of ECTFE in the dope-solution and the time of dip-coating on the thickness of ECTFE layer and membrane properties (i.e., contact angle and pore size. ECTFE coating decreased the surface roughness reducing, as a consequence, the hydrophobicity of the membrane. Moreover, increasing the ECTFE concentration and dip-coating time enabled the preparation of a thicker layer of ECTFE with low and narrow pore size that negatively affected the water transport. On the basis of the superior chemical resistance of ECTFE, ECTFE/PP composite hollow fibers could be considered as very promising candidates to be employed in membrane processes involving harsh conditions.

  9. $pp$ Elastic Scattering at LHC and Nucleon Structure

    CERN Document Server

    Islam, M M; Prokudin, A V

    2003-01-01

    High energy elastic pp differential cross section at LHC at the c.m. energy 14 TeV is predicted using the asymptotic behavior of sigma-tot(s) and rho(s), and the measured pbar-p differential cross section at sqrt{s}=546 GeV. The phenomenological investigation has progressively led to an effective field theory model that describes the nucleon as a chiral bag embedded in a quark-antiquark condensed ground state. The measurement of pp elastic scattering at LHC up to large |t| >~ 10 GeV^2 by the TOTEM group will be crucial to test this structure of the nucleon.

  10. pp Elastic Scattering at LHC and Nucleon Structure

    CERN Document Server

    Islam, M M; Prokudin, A V

    2003-01-01

    High energy elastic pp differential cross section at LHC at the c.m. energy 14 TeV is predicted using the asymptotic behavior of tot(s) and (s), and the measured p differential cross section at =546 GeV. The phenomenological investigation has progressively led to an effective field theory model that describes the nucleon as a chiral bag embedded in a quark-antiquark condensed ground state. The measurement of pp elastic scattering at LHC up to large |t| 10 GeV2 by the TOTEM group will be crucial to test this structure of the nucleon.

  11. Characterization of dispersion of a nano composites PP/TiO2 non modified

    International Nuclear Information System (INIS)

    Soares, Igor L.; Tavares, Maria I.B.; Silva, Vanessa A. da; Legramanti, Cintia; Luetkmeyer, Leandro

    2011-01-01

    Polymeric nano composites are composite materials where an inorganic particle, which has a dimension in the nanometer range, is dispersed in a polymer matrix. Nano composites, using polypropylene (PP) as matrix polymer and titanium dioxide (TiO 2 ) as filler, have great versatility in marketing applications, this factor is inherent in the PP and the inherent ability photo degraded TiO 2 particles. This combination can lead to a widely used material and a degradation time after discharge reduced, there by becoming, a residue of low environmental impact. This study aimed to evaluate the dispersion and particle distribution of TiO 2 , non modified, in PP matrix, using the process of preparation by melt extrusion pathway and characterization of the materials obtained: on the molecular dynamics, using low field NMR solid state, measures the relaxation time spin-network (T 1 H); morphology using XRD technique, and thermal analysis technique with the TGA of pure PP and nano composites PP/TiO 2 . (author)

  12. Evidence for collectivity in pp collisions at the LHC

    Directory of Open Access Journals (Sweden)

    V. Khachatryan

    2017-02-01

    Full Text Available Measurements of two- and multi-particle angular correlations in pp collisions at s=5,7, and 13TeV are presented as a function of charged-particle multiplicity. The data, corresponding to integrated luminosities of 1.0pb−1 (5 TeV, 6.2pb−1 (7 TeV, and 0.7pb−1 (13 TeV, were collected using the CMS detector at the LHC. The second-order (v2 and third-order (v3 azimuthal anisotropy harmonics of unidentified charged particles, as well as v2 of KS0 and Λ/Λ‾ particles, are extracted from long-range two-particle correlations as functions of particle multiplicity and transverse momentum. For high-multiplicity pp events, a mass ordering is observed for the v2 values of charged hadrons (mostly pions, KS0, and Λ/Λ‾, with lighter particle species exhibiting a stronger azimuthal anisotropy signal below pT≈2GeV/c. For 13 TeV data, the v2 signals are also extracted from four- and six-particle correlations for the first time in pp collisions, with comparable magnitude to those from two-particle correlations. These observations are similar to those seen in pPb and PbPb collisions, and support the interpretation of a collective origin for the observed long-range correlations in high-multiplicity pp collisions.

  13. Theoretical study on pp → pnπ+ reaction at medium energies

    International Nuclear Information System (INIS)

    Ouyang, Zhen; Xie, Jujun; Zou, Bingsong; Xu, Hushan

    2009-01-01

    The pp → pnπ + reaction is a channel with the largest total cross section for pp collision in COSY/CSR energy region. In this work, we investigate individual contributions from various N* and Δ* resonances with mass up to about 2 GeV for the pp → pnπ + reaction. We extend a resonance model, which can reproduce the observed total cross section quite well, to give theoretical predictions of various differential cross sections for the present reaction at T p = 2.88 GeV. It could serve as a reference for identifying new physics in the future experiments at HIRFL-CSR. (author)

  14. Abstract Interpretation-based verification/certification in the ciaoPP system

    OpenAIRE

    Puebla Sánchez, Alvaro Germán; Albert Albiol, Elvira; Hermenegildo, Manuel V.

    2005-01-01

    CiaoPP is the abstract interpretation-based preprocessor of the Ciao multi-paradigm (Constraint) Logic Programming system. It uses modular, incremental abstract interpretation as a fundamental tool to obtain information about programs. In CiaoPP, the semantic approximations thus produced have been applied to perform high- and low-level optimizations during program compilation, including transformations such as múltiple abstract specialization, parallelization, partial evaluation, resource...

  15. Effects of radiation on the physical properties of PP membrane for the removal of dissolved oxygen

    International Nuclear Information System (INIS)

    Kang, D. W.; Song, Y. W.; Kim, M. S.; Ji, J. H.; Kim, S. I.

    2003-01-01

    The physical properties of polypropylene (PP) hollow fiber membranes and its deoxygenation efficiency were investigated. We supposed the conditions of PP hollow fiber membranes under radiation field and irradiated the PP membranes using differential scanning calorimetry(DSC), thermal gravimetric analyzer (TGA), fourier transform infrared (FT-IR), and contact angle. In addition, the deoxygenation efficiency of the exposed PP membranes was estimated by using an oxygen removal test kit. From the results, we found that the physical properties and deoxygenation efficiency of PP membrane was still keep good condition under the simulated radiation field

  16. Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases

    International Nuclear Information System (INIS)

    Soon, Fen-Fen; Ng, Ley-Moy; Zhou, X. Edward; West, Graham M.; Kovach, Amanda; Tan, M.H. Eileen; Suino-Powell, Kelly M.; He, Yuanzheng; Xu, Yong; Chalmers, Michael J.; Brunzelle, Joseph S.; Zhang, Huiming; Yang, Huaiyu; Jiang, Hualiang; Li, Jun; Yong, Eu-Leong; Cutler, Sean; Zhu, Jian-Kang; Griffin, Patrick R.; Melcher, Karsten; Xu, H. Eric

    2012-01-01

    Abscisic acid (ABA) is an essential hormone for plants to survive environmental stresses. At the center of the ABA signaling network is a subfamily of type 2C protein phosphatases (PP2Cs), which form exclusive interactions with ABA receptors and subfamily 2 Snfl-related kinase (SnRK2s). Here, we report a SnRK2-PP2C complex structure, which reveals marked similarity in PP2C recognition by SnRK2 and ABA receptors. In the complex, the kinase activation loop docks into the active site of PP2C, while the conserved ABA-sensing tryptophan of PP2C inserts into the kinase catalytic cleft, thus mimicking receptor-PP2C interactions. These structural results provide a simple mechanism that directly couples ABA binding to SnRK2 kinase activation and highlight a new paradigm of kinase-phosphatase regulation through mutual packing of their catalytic sites.

  17. Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases

    Energy Technology Data Exchange (ETDEWEB)

    Soon, Fen-Fen; Ng, Ley-Moy; Zhou, X. Edward; West, Graham M.; Kovach, Amanda; Tan, M.H. Eileen; Suino-Powell, Kelly M.; He, Yuanzheng; Xu, Yong; Chalmers, Michael J.; Brunzelle, Joseph S.; Zhang, Huiming; Yang, Huaiyu; Jiang, Hualiang; Li, Jun; Yong, Eu-Leong; Cutler, Sean; Zhu, Jian-Kang; Griffin, Patrick R.; Melcher, Karsten; Xu, H. Eric (Van Andel); (Scripps); (NWU); (Purdue); (UCR); (Chinese Aca. Sci.); (NU Singapore)

    2014-10-02

    Abscisic acid (ABA) is an essential hormone for plants to survive environmental stresses. At the center of the ABA signaling network is a subfamily of type 2C protein phosphatases (PP2Cs), which form exclusive interactions with ABA receptors and subfamily 2 Snfl-related kinase (SnRK2s). Here, we report a SnRK2-PP2C complex structure, which reveals marked similarity in PP2C recognition by SnRK2 and ABA receptors. In the complex, the kinase activation loop docks into the active site of PP2C, while the conserved ABA-sensing tryptophan of PP2C inserts into the kinase catalytic cleft, thus mimicking receptor-PP2C interactions. These structural results provide a simple mechanism that directly couples ABA binding to SnRK2 kinase activation and highlight a new paradigm of kinase-phosphatase regulation through mutual packing of their catalytic sites.

  18. Transverse Imaging of the Proton in Exclusive Diffractive pp Scattering

    International Nuclear Information System (INIS)

    Christian Weiss; Leonid Frankfurt; Charles Hyde-Wright; Mark Strikman

    2006-01-01

    In a forthcoming paper we describe a new approach to rapidity gap survival (RGS) in the production of high-mass systems (H = dijet, Higgs, etc.) in exclusive double-gap diffractive pp scattering, pp -> p + H + p. It is based on the idea that hard and soft interactions are approximately independent (QCD factorization), and allows us to calculate the RGS probability in a model-independent way in terms of the gluon generalized parton distributions (GPDs) in the colliding protons and the pp elastic scattering amplitude. Here we focus on the transverse momentum dependence of the cross section. By measuring the ''diffraction pattern'', one can perform detailed tests of the interplay of hard and soft interactions, and even extract information about the gluon GPD in the proton from the data

  19. First direct detection of solar pp neutrinos by Borexino

    Energy Technology Data Exchange (ETDEWEB)

    Maneschg, Werner [Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany); Collaboration: Werner Maneschg on behalf of the Borexino collaboration

    2015-07-01

    According to the Standard Solar Model (SSM) the radiative energy of our Sun is produced by a series of nuclear reactions that convert hydrogen into helium. In 99% of cases these processes are supposed to start with a fusion of two protons and the emission of a positron and a low-energy neutrino. These so-called pp neutrinos vastly outnumber those emitted in other sub-reactions, but only the large volume organic liquid scintillator detector Borexino has recently succeeded to perform a spectroscopic and direct measurement of them. The present talk reviews the procedure adopted by the Borexino collaboration to detect pp neutrinos. The key requirements, i.e. unprecedented radiopurity levels at low energies and a precise spectral description of the main background arising from 14C decays, and their fulfillment are discussed. The measured pp neutrino flux is then compared with the predictions of the SSM including neutrino oscillation mechanisms, and with the solar luminosity constraint deduced from photospheric observations.

  20. Redundancy in Nigerian Business Organizations: Alternatives (Pp ...

    African Journals Online (AJOL)

    FIRST LADY

    Redundancy in Nigerian Business Organizations: Alternatives (Pp. ... When business downturns ... The galloping pace of information technologies is a harbinger of profound ... Redundant staff in public departments can also be retained as.

  1. Enhanced interfacial radiation-induced reaction for improving the interfacial adhesion of incompatible polymer blend PP/BR

    International Nuclear Information System (INIS)

    Liu Changhai; Yang Huili; Xu Jun

    1995-01-01

    γ-radiation induced interfacial changes of incompatible polymer isotactic polypropylene (PP) and cis1,4-polybutadiene (BR) blends containing polyfunctional monomer (PFM) triallyl isocyanurate (TAIC) were investigated. The results of the study are as following: PP is incompatible with BR; TAIC is hardly dissolved in both PP and BR; when blended with PP/BR, the concentration of TAIC in the interfacial region is higher than that in dispersion phase of BR or matrix of PP. The crosslinking and/or grafting of which TAIC occurred under radiation in the interfacial region anchored the dispersed BR phase to PP matrix. The interaction between adjacent phases is changed from sole van der Waals force to co-action of both chemical bond and molecular forces. Crosslinking between adjacent phases links the dispersed phase with PP matrix, and grafting in the boundary regions increases the thickness of interface. These result in a good interfacial adhesion between dispersed phase and matrix. (author)

  2. ISAJET 5.02: a Monte Carlo event generator for pp and anti pp interactions

    International Nuclear Information System (INIS)

    Paige, F.E.; Protopopescu, S.D.

    1985-01-01

    ISAJET is a Monte Carlo program which simulates pp and anti p p interactions at high energy. It is based on perturbative QCD cross sections, leading order QCD radiative corrections for initial and final state partons, and phenomenological models for jet and beam jet fragmentation. This article describes ISAJET 5.02, which is identical with Version 5.00 except for minor corrections. 27 refs., 7 figs

  3. The combinatorial PP1-binding consensus Motif (R/Kx( (0,1V/IxFxx(R/Kx(R/K is a new apoptotic signature.

    Directory of Open Access Journals (Sweden)

    Angélique N Godet

    Full Text Available BACKGROUND: Previous studies established that PP1 is a target for Bcl-2 proteins and an important regulator of apoptosis. The two distinct functional PP1 consensus docking motifs, R/Kx((0,1V/IxF and FxxR/KxR/K, involved in PP1 binding and cell death were previously characterized in the BH1 and BH3 domains of some Bcl-2 proteins. PRINCIPAL FINDINGS: In this study, we demonstrate that DPT-AIF(1, a peptide containing the AIF(562-571 sequence located in a c-terminal domain of AIF, is a new PP1 interacting and cell penetrating molecule. We also showed that DPT-AIF(1 provoked apoptosis in several human cell lines. Furthermore, DPT-APAF(1 a bi-partite cell penetrating peptide containing APAF-1(122-131, a non penetrating sequence from APAF-1 protein, linked to our previously described DPT-sh1 peptide shuttle, is also a PP1-interacting death molecule. Both AIF(562-571 and APAF-1(122-131 sequences contain a common R/Kx((0,1V/IxFxxR/KxR/K motif, shared by several proteins involved in control of cell survival pathways. This motif combines the two distinct PP1c consensus docking motifs initially identified in some Bcl-2 proteins. Interestingly DPT-AIF(2 and DPT-APAF(2 that carry a F to A mutation within this combinatorial motif, no longer exhibited any PP1c binding or apoptotic effects. Moreover the F to A mutation in DPT-AIF(2 also suppressed cell penetration. CONCLUSION: These results indicate that the combinatorial PP1c docking motif R/Kx((0,1V/IxFxxR/KxR/K, deduced from AIF(562-571 and APAF-1(122-131 sequences, is a new PP1c-dependent Apoptotic Signature. This motif is also a new tool for drug design that could be used to characterize potential anti-tumour molecules.

  4. Inclusive\\pi^{0} production at the CERN p-p collider

    CERN Document Server

    Banner, M; Bonaudi, Franco; Borer, K; Borghini, M; Chollet, J C; Clark, A G; Conta, C; Darriulat, Pierre; Di Lella, L; Dines-Hansen, J; Dorsaz, P A; Fayard, L; Fraternali, M; Froidevaux, D; Gaillard, J M; Gildemeister, O; Goggi, V G; Grote, H; Hahn, B; Hänni, H; Hansen, J R; Hansen, P; Himel, T; Hungerbühler, V; Jenni, Peter; Kofoed-Hansen, Otto Møgens; Livan, M; Loucatos, Sotirios S; Madsen, B; Mansoulié, B; Mantovani, G C; Mapelli, L; Merkel, B; Møllerud, R; Nilsson, B; Onions, Christopher J; Parrour, G; Pastore, F; Plothow-Besch, H; Repellin, J P; Ringel, J; Rothenberg, A F; Roussarie, A; Sauvage, G; Schacher, J; Siegrist, J L; Stocker, F; Teiger, J; Vercesi, V; Zaccone, Henri; Zeller, W

    1982-01-01

    Inclusive\\pi^{0} production has been measured at the CERN pp collider, \\sqrt{s}=540 GeV, for 90 degrees production angle and in a range of transverse moment between 1.5 and 4.5 GeV/c. The invariant production cross section is larger than that measured at \\sqrt{s}=53 GeV for p-p collisions. The production of mu mesons and of direct photons is also investigated.

  5. W,Z0 production at the pp collider

    International Nuclear Information System (INIS)

    Bunce, G.; Gordon, H.A.; Killian, T.J.

    1982-01-01

    We have examined some experimental questions relating to the production of W's and Z 0 's at a pp collider. To be specific we have considered a Colliding Beam Accelerator (CBA) with center of energy √s = 800 GeV and luminosity L = 10 33 cm -2 sec -1 (the standard BNL Isabelle (ISA) operating conditions). Most experiments should accumulate 10 sec of beam and therefore will have an integrated luminosity L = 10 40 cm -2 . This corresponds to the production of millions of conventional charged W's per interaction region and gives the potential for high statistics studies of the properties of W's and for experiments searching for higher mass objects. Our focus has been on testing predictions of the standard model. We have concentrated on W production since it is likely the standard Z 0 will be observed in the near future. In most cases the W is detected via its semileptonic decay W → l + nu. The specific topics considered are: W +- production: pp → W +- + X, W +- → e +- + nu, pp → W +- + γ + X, polarization effects in W +- production, and very high luminosity experiments

  6. Photochemical surface modification of PP for abrasion resistance

    International Nuclear Information System (INIS)

    Bahners, Thomas; Haessler, Ruediger; Gao Shanglin; Maeder, Edith; Wego, Andreas; Schollmeyer, Eckhard

    2009-01-01

    The potential of a photo-chemical approach to increase the surface hardness of polypropylene (PP) has been studied. Using a 222 nm excimer lamp, fibers and film were irradiated in the presence of multi-functional substances diallylphthalate (DAP), tetraallyloxyethane (TAE), and pentaerithritoltriacylate (PETA) and characterized with regard to the resulting effect on abrasion resistance. AFM-based methods were employed to analyze thermo-mechanical surface properties. Nanoindentation and microthermal analyses of the outermost surface layers of UV treated fibers gave clear indications of an effective cross-linking of reactive substances present during irradiation. One may assume that the reactive media polymerize on top of the surface of the PP substrate and form a thin-layer. The abrasion resistance of the PP fibers was tested by applying stress through a rotating and axially oscillating roller of defined roughness and measuring the mass loss as a function of time. The abrasion resistance was found to be remarkably improved compared to the untreated fiber. Best effects were achieved using PETA as reactive substance. The experiments clearly showed the influence of processing conditions, namely with regard to homogeneous coverage of the substrate surface with the reactive medium.

  7. Charm baryon production in pp and p-Pb collisions with ALICE

    CERN Multimedia

    CERN. Geneva

    2018-01-01

    The measurement of inclusive open heavy-flavour production in pp collisions is an important test of perturbative QCD calculations, and also offers a direct way to study non-perturbative QCD processes. Charmed baryon production measurements, in particular, are useful to address the hadronisation of charm quarks. Measurements in pp and p-Pb collisions also provide a baseline for Pb-Pb collisions, where the baryon-to-meson ratios will offer a unique probe of charm thermalisation and hadronisation mechanisms in the Quark-Gluon Plasma. The production of D0, D+, D*+ and Ds mesons has been measured with ALICE in pp collisions at the LHC at several collision energies, and was found to be compatible with expectations from theory. In this talk, recent measurements of Λc+ and Ξc0 baryon production in pp collisions at a centre-of-mass energy of 7 TeV and Λc+ baryon production in p-Pb collisions at a centre-of-mass energy per nucleon pair of 5.02 TeV will be presented. The reconstruction of charmed baryons at central ...

  8. Status, remaining service-life and quality assurance of PP-materials in flue-gas applications; Status, kvarvarande livslaengd och kvalitetssaekring av PP-material i anlaeggningar foer rening och kondensering av roekgaser

    Energy Technology Data Exchange (ETDEWEB)

    Jacobson, Karin

    2011-10-15

    Background: The project is intended to provide a better understanding of how the service life of PP-materials is affected when used in flue-gas applications. It intends to form a basis for the development of relevant techniques and a methodology from which it is possible to give advice and guidance so that the quality of PP-materials can be ensured for a given desired service life. In addition it aims as being able to assess the status and remaining life of PP-materials in current components. Project outline - An inventory, contact and choice of facilities for closer cooperation. Plants with high proportions of PP in the equipment have been prioritised. - Visits to the chosen sites during shut-down periods for inspection and collection of samples from different PP details for further analysis in the laboratory. Collection of operating data and experiences of the use of PP (operating time/exposure conditions in different parts, component substitutions that have been made, etc.). - Systematic studies of the processes and mechanisms for stabiliser consumption over time. - Developing methods and methodology on which advice and guidance can be based so that the quality of PP-materials can be ensured for a given desired service life. The goal is to be able to assess the status and remaining service-life of the PP-materials in flue-gas applications. Results and Conclusions: It has been found that corrosion is relatively rare and that the main factors limiting the use and longevity of polypropylene are the thermal properties (thermal expansion and heat distortion). Leaching of stabilisers from the material is also commonly found but only a few cases of oxidative degradation, as a result of this, have been observed. An important part of the project has been to develop techniques and methodologies to assure the quality PP-material for a desired service life, and to assess the status and remaining life of the PP- materials in flue-gas applications. To do this, samples that

  9. Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases

    Science.gov (United States)

    Soon, Fen-Fen; Ng, Ley-Moy; Zhou, X. Edward; West, Graham M.; Kovach, Amanda; Tan, M. H. Eileen; Suino-Powell, Kelly M.; He, Yuanzheng; Xu, Yong; Chalmers, Michael J.; Brunzelle, Joseph S.; Zhang, Huiming; Yang, Huaiyu; Jiang, Hualiang; Li, Jun; Yong, Eu-Leong; Cutler, Sean; Zhu, Jian-Kang; Griffin, Patrick R.; Melcher, Karsten; Xu, H. Eric

    2013-01-01

    Abscisic acid (ABA) is an essential hormone for plants to survive environmental stresses. At the center of the ABA signaling network is a subfamily of type 2C protein phosphatases (PP2Cs), which form exclusive interactions with ABA receptors and subfamily 2 Snfl-related kinase (SnRK2s). Here, we report a SnRK2-PP2C complex structure, which reveals marked similarity in PP2C recognition by SnRK2 and ABA receptors. In the complex, the kinase activation loop docks into the active site of PP2C, while the conserved ABA-sensing tryptophan of PP2C inserts into the kinase catalytic cleft, thus mimicking receptor-PP2C interactions. These structural results provide a simple mechanism that directly couples ABA binding to SnRK2 kinase activation and highlight a new paradigm of kinase-phosphatase regulation through mutual packing of their catalytic sites. PMID:22116026

  10. Evaluation of biodegradation of bionanocomposites of PHB/PP-g-MA/vermiculite; Avaliacao da biodegradacao de bionanocompositos de PHB/PP-g-MA/vermiculita

    Energy Technology Data Exchange (ETDEWEB)

    Mesquita, P.J.P. de; Alves, T.S.; Barbosa, R., E-mail: tsaeng3@yahoo.com.br [Universidade Federal do Piaui (UFPI), Teresina, PI (Brazil). Programa de Pos-Graduacao em Ciencia dos Materiais; Andrade, D. de L.A.C.S. [Universidade Federal de Campina Grande (UFCG), PB (Brazil). Programa de Pos- Graduacao em Ciencia e Engenharia de Materiais

    2014-07-01

    In this work, we evaluated the process of biodegradation of PHB bionanocomposites/PP-g-MA/clay. Films were prepared with compositions of 5% PP-g-MA and 3% clay (BIO5); and 2.5% PP-g-MA and 3% clay (BIO2.5). The biodegradation test was conducted according to ASTM G 160-03 for a period of 86 days. The evaluation of biodegradation was performed by optical microscopy (MO), loss of mass, FTIR and XRD. The bionanocomposites presented change of coloration and appearance of fissures. As for loss in mass in the system presented loss of BIO2,5 22.5% and 25.9% BIO5, for 86 days of simulated soil exposure. We also observed by FTIR sharp reduction in intensity of the band corresponding to the C = O groups, indicating that the microbial attack promoted cleavage of the ester group links. By XRD, reduction in the intensity of the peaks and enlargements of the same with increasing exposure time, proving the biodegradation behavior of bionanocomposites. (author)

  11. Riboswitches for the alarmone ppGpp expand the collection of RNA-based signaling systems.

    Science.gov (United States)

    Sherlock, Madeline E; Sudarsan, Narasimhan; Breaker, Ronald R

    2018-05-21

    Riboswitches are noncoding portions of certain mRNAs that bind metabolite, coenzyme, signaling molecule, or inorganic ion ligands and regulate gene expression. Most known riboswitches sense derivatives of RNA monomers. This bias in ligand chemical composition is consistent with the hypothesis that widespread riboswitch classes first emerged during the RNA World, which is proposed to have existed before proteins were present. Here we report the discovery and biochemical validation of a natural riboswitch class that selectively binds guanosine tetraphosphate (ppGpp), a widespread signaling molecule and bacterial "alarmone" derived from the ribonucleotide GTP. Riboswitches for ppGpp are predicted to regulate genes involved in branched-chain amino acid biosynthesis and transport, as well as other gene classes that previously had not been implicated to be part of its signaling network. This newfound riboswitch-alarmone partnership supports the hypothesis that prominent RNA World signaling pathways have been retained by modern cells to control key biological processes. Copyright © 2018 the Author(s). Published by PNAS.

  12. Development of foams from linear polypropylene (PP) and high melt strength polypropylene (HMSPP) polymeric blends

    International Nuclear Information System (INIS)

    Cardoso, Elisabeth Carvalho Leite

    2009-01-01

    Foamed polymers are future materials, with a comprehensive application field. They can be used in order to improve appearance of insulation structures, for example, or to reduce costs involving materials. This work address to Isotactic Polypropylene / High Melt Strength Polypropylene blends, for foams production. Rheological behavior of polymer melt, especially referring to viscosity in processing temperature, plays a decisive role in applications where dominates extensional flow, as in case of foaming. If the viscosity is very low, it will correspond to a low melt strength, as in case of linear homopolymer (Isotact PP), and the foam will be prejudiced, due to the impossibility of expansion. Otherwise, if the viscosity is very high, with a high melt strength, the foam will collapse immediately after its formation. In order to get foams with an homogeneous and defined cellular structure, there were accomplished blends, 50% in weight, between linear homopolymer (isotactic PP) and HMSPP, from PP modified as per gamma radiation, in acetylene environment and at a 12.5 kGy doses. Extrusion process used a soluble foaming methodology, according to a processing/dissolution principle, which involves the dissolution of a Physical Blowing Agent (PBA), under 30 bar pressure, homogeneously mixed with polymeric melt. Extrusion conditions, that generally involve temperature, pressure and viscoelastic material flow control were experimentally investigated to define prevalent characteristics for producing foams. Nitrogen was the used PBA and process extrusion parameters were adapted to PP, HMSPP and their 50% in weight mixtures thereof. Major PP and HMSPP characteristics were obtained via melt Index and melt strength and thermal analyses (DSC/TGA), in order to make viable and to reproduce foaming as per extrusion process. Foams cellular morphology of PP, HMSPP and their 50% in weight mixtures thereof was investigated, with and without talc addition, as nucleating agent, by using

  13. The upcycling of post-industrial PP/PET waste streams through in-situ microfibrillar preparation

    International Nuclear Information System (INIS)

    Delva, Laurens; Ragaert, Kim; Cardon, Ludwig

    2015-01-01

    Post-industrial plastic waste streams can be re-used as secondary material streams for polymer processing by extrusion or injection moulding. One of the major commercially available waste stream contains polypropylene (PP) contaminated with polyesters (mostly polyethylene tereftalate - PET). An important practical hurdle for the direct implementation of this waste stream is the immiscibility of PP and PET in the melt, which leads to segregation within the polymer structure and adversely affects the reproducibility and mechanical properties of the manufactured parts. It has been indicated in literature that the creation of PET microfibrils in the PP matrix could undo these drawbacks and upcycle the PP/PET combination. Within the current research, a commercially available virgin PP/PET was evaluated for the microfibrillar preparation. The mechanical (tensile and impact) properties, thermal properties and morphology of the composites were characterized at different stages of the microfibrillar preparation

  14. The upcycling of post-industrial PP/PET waste streams through in-situ microfibrillar preparation

    Energy Technology Data Exchange (ETDEWEB)

    Delva, Laurens, E-mail: Laurens.Delva@ugent.be; Ragaert, Kim, E-mail: Kim.Ragaert@ugent.be; Cardon, Ludwig, E-mail: Ludwig.Cardon@ugent.be [Centre for Polymer and Materials Technologies (CPMT), Department of Materials Science and Engineering, Ghent University, Technologiepark 915, 9052 Zwijnaarde (Belgium)

    2015-12-17

    Post-industrial plastic waste streams can be re-used as secondary material streams for polymer processing by extrusion or injection moulding. One of the major commercially available waste stream contains polypropylene (PP) contaminated with polyesters (mostly polyethylene tereftalate - PET). An important practical hurdle for the direct implementation of this waste stream is the immiscibility of PP and PET in the melt, which leads to segregation within the polymer structure and adversely affects the reproducibility and mechanical properties of the manufactured parts. It has been indicated in literature that the creation of PET microfibrils in the PP matrix could undo these drawbacks and upcycle the PP/PET combination. Within the current research, a commercially available virgin PP/PET was evaluated for the microfibrillar preparation. The mechanical (tensile and impact) properties, thermal properties and morphology of the composites were characterized at different stages of the microfibrillar preparation.

  15. The upcycling of post-industrial PP/PET waste streams through in-situ microfibrillar preparation

    Science.gov (United States)

    Delva, Laurens; Ragaert, Kim; Cardon, Ludwig

    2015-12-01

    Post-industrial plastic waste streams can be re-used as secondary material streams for polymer processing by extrusion or injection moulding. One of the major commercially available waste stream contains polypropylene (PP) contaminated with polyesters (mostly polyethylene tereftalate - PET). An important practical hurdle for the direct implementation of this waste stream is the immiscibility of PP and PET in the melt, which leads to segregation within the polymer structure and adversely affects the reproducibility and mechanical properties of the manufactured parts. It has been indicated in literature that the creation of PET microfibrils in the PP matrix could undo these drawbacks and upcycle the PP/PET combination. Within the current research, a commercially available virgin PP/PET was evaluated for the microfibrillar preparation. The mechanical (tensile and impact) properties, thermal properties and morphology of the composites were characterized at different stages of the microfibrillar preparation.

  16. PpRT1: the first complete gypsy-like retrotransposon isolated in Pinus pinaster.

    Science.gov (United States)

    Rocheta, Margarida; Cordeiro, Jorge; Oliveira, M; Miguel, Célia

    2007-02-01

    We have isolated and characterized a complete retrotransposon sequence, named PpRT1, from the genome of Pinus pinaster. PpRT1 is 5,966 bp long and is closely related to IFG7 gypsy retrotransposon from Pinus radiata. The long terminal repeats (LTRs) have 333 bp each and show a 5.4% sequence divergence between them. In addition to the characteristic polypurine tract (PPT) and the primer binding site (PBS), PpRT1 carries internal regions with homology to retroviral genes gag and pol. The pol region contains sequence motifs related to the enzymes protease, reverse transcriptase, RNAseH and integrase in the same typical order known for Ty3/gypsy-like retrotransposons. PpRT1 was extended from an EST database sequence indicating that its transcription is occurring in pine tissues. Southern blot analyses indicate however, that PpRT1 is present in a unique or a low number of copies in the P. pinaster genome. The differences in nucleotide sequence found between PpRT1 and IFG7 may explain the strikingly different copy number in the two pine species genome. Based on the homologies observed when comparing LTR region among different gypsy elements we propose that the highly conserved LTR regions may be useful to amplify other retrotransposon sequences of the same or close retrotransposon family.

  17. Tri-Service Green Gun Barrel (PP 1074)

    National Research Council Canada - National Science Library

    Rusch, Lawrence F

    2003-01-01

    ...) PP 1074 Tri-Service Green Gun Barrel. The program's goal was to develop an environmentally friendly process for depositing wear and erosion resistant materials onto gun bores replacing the current hazardous aqueous electro-deposition...

  18. Virtual-pion and two-photon production in pp scattering

    International Nuclear Information System (INIS)

    Scholten, O.; Korchin, A.Yu.

    2002-01-01

    Two-photon production in pp scattering is proposed as a means of studying virtual-pion emission. Such a process is complementary to real-pion emission in pp scattering. The virtual-pion signal is embedded in a background of double-photon bremsstrahlung. We have developed a model to describe this background process and show that in certain parts of phase space the virtual-pion signal gives significant contributions. In addition, through interference with the two-photon bremsstrahlung background, one can determine the relative phase of the virtual-pion process

  19. Transcriptomic and Functional Analyses Reveal That PpGLK1 Regulates Chloroplast Development in Peach (Prunus persica

    Directory of Open Access Journals (Sweden)

    Min Chen

    2018-01-01

    Full Text Available Peach is an ideal species for fruit tree research because of its small, fully sequenced genome. Chloroplast development is dependent on the tight cooperation between the nuclear and plastid genomes, and is regulated by GLK transcription factors. In this work, the pigment content was monitored and the chloroplast-to-chromoplast conversion during the fruit ripening was visualized by transmission electron microscopy. Localization and expression analyses showed that PpGLK1 was located in the nucleus and expressed mainly in the leaves and fruit skin. A transcriptome analysis showed that PpGLK1 and its target genes were significantly differentially expressed in ripening peach fruit skin. PpGLK1 silencing affected chlorophyll accumulation in peach leaves and fruits. Overexpression of PpGLK1 rescued the phenotypes of the Arabidopsis Atglk1Atglk2 double mutant and the tomato uniform ripening mutant. The results of a yeast two-hybrid analysis showed that PpGLK1 is autoactivated and that PpGLK1 (301-542 a.a. interacted with PpARF5. Together, our results indicate that PpGLK1 regulates chloroplast development in green tissues in peach. Therefore, it may be a promising target gene for improving the production and quality of peach by genetic engineering and breeding approaches.

  20. PR and PP evaluation. ESFR full system case study final report (Tentative translation)

    International Nuclear Information System (INIS)

    Sagara, Hiroshi; Kawakubo, Yoko; Inoue, Naoko

    2014-01-01

    The Generation IV (GEN IV) International Forum (GIF) Proliferation Resistance and Physical Protection Working Group (PRPP WG) was established in December, 2002, as one of the crosscut groups under GIF, in order to develop a methodology for evaluating PR and PP of potential GEN IV options. The group currently consists of the experts from the U.S. national laboratories and universities, from Canada, France, Republic of Korea (ROK), Japan, the International Atomic Energy Agency (IAEA), and European Union(EU). The present report, published in Oct. 2009, was used as a supporting study for development of the evaluation methodology for proliferation resistance and physical protection of GEN IV nuclear energy systems. The present report is summarizing the case study of the PR and PP evaluation of Example Sodium Fast Reactor (ESFR), a hypothetical nuclear energy system consisting of nine main system elements, and it provides for designers the practical experience of applying the PR and PP evaluation methodology to a nuclear energy system. The development of the future nuclear fuel cycle system with sufficient PR and PP features is a crucial task in Japan, and the demonstration and explanation about its effectiveness to the domestic and international society will be required. With the usefulness the present report for such purposes, it was translated and published here as a Japanese-language edition with the concurrence of the OECD-NEA. The original report in English language can be downloaded at the OECD-NEA website. The translation was performed as closely as possible to the original, and special attention was paid to the technical term translation for consistency. Terms difficult to be translated appropriately into Japanese was written with the original English wording. Safeguards terms were translated with reference to “IAEA Safeguards Glossary 2001 Edition” (Japanese), published by the Nuclear Material Control Center Japan (NMCC). The authors are grateful to the GIF

  1. Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases

    OpenAIRE

    Soon, Fen-Fen; Ng, Ley-Moy; Zhou, X. Edward; West, Graham M.; Kovach, Amanda; Tan, M. H. Eileen; Suino-Powell, Kelly M.; He, Yuanzheng; Xu, Yong; Chalmers, Michael J.; Brunzelle, Joseph S.; Zhang, Huiming; Yang, Huaiyu; Jiang, Hualiang; Li, Jun

    2011-01-01

    Abscisic acid (ABA) is an essential hormone for plants to survive environmental stresses. At the center of the ABA signaling network is a subfamily of type 2C protein phosphatases (PP2Cs), which form exclusive interactions with ABA receptors and subfamily 2 Snfl-related kinase (SnRK2s). Here, we report a SnRK2-PP2C complex structure, which reveals marked similarity in PP2C recognition by SnRK2 and ABA receptors. In the complex, the kinase activation loop docks into the active site of PP2C, wh...

  2. Some Aspects of the OZI-Rule Violation in the Reaction Anti pp → φπ0

    International Nuclear Information System (INIS)

    Buzatu, D.; Lev, F.M.

    1994-01-01

    We consider the problem whether the violation of the OZI-rule in the reaction anti pp → φπ 0 can be explained as the effect of rescattering in the processes anti pp → (K*anti K + anti K*K) → K anti Kπ 0 → φπ 0 and (or) anti pp → ρ + ρ - → (ρ + π - + ρ - π + )π 0 → φπ 0 . If this effect is important then it is possible to give theoretical predictions concerning the energy dependence of the quantity BR(anti pp → φπ 0 )/BR(anti pp → K*anti K) and the value of this quantity in the annihilation at rest from the P state. At the same time the analogous effect in the reaction anti pp → f 2 'π 0 is negligible. 14 refs., 7 figs

  3. The PP2A Regulatory Subunit Tap46, a Component of the TOR Signaling Pathway, Modulates Growth and Metabolism in Plants[W

    Science.gov (United States)

    Ahn, Chang Sook; Han, Jeong-A; Lee, Ho-Seok; Lee, Semi; Pai, Hyun-Sook

    2011-01-01

    Tap42/α4, a regulatory subunit of protein phosphatase 2A, is a downstream effector of the target of rapamycin (TOR) protein kinase, which regulates cell growth in coordination with nutrient and environmental conditions in yeast and mammals. In this study, we characterized the functions and phosphatase regulation of plant Tap46. Depletion of Tap46 resulted in growth arrest and acute plant death with morphological markers of programmed cell death. Tap46 interacted with PP2A and PP2A-like phosphatases PP4 and PP6. Tap46 silencing modulated cellular PP2A activities in a time-dependent fashion similar to TOR silencing. Immunoprecipitated full-length and deletion forms of Arabidopsis thaliana TOR phosphorylated recombinant Tap46 protein in vitro, supporting a functional link between Tap46 and TOR. Tap46 depletion reproduced the signature phenotypes of TOR inactivation, such as dramatic repression of global translation and activation of autophagy and nitrogen mobilization, indicating that Tap46 may act as a positive effector of TOR signaling in controlling those processes. Additionally, Tap46 silencing in tobacco (Nicotiana tabacum) BY-2 cells caused chromatin bridge formation at anaphase, indicating its role in sister chromatid segregation. These findings suggest that Tap46, in conjunction with associated phosphatases, plays an essential role in plant growth and development as a component of the TOR signaling pathway. PMID:21216945

  4. Influence of the use of organoclays on the morphology of PP/EPDM blends

    International Nuclear Information System (INIS)

    Ferreira, K.R.M.; Andrade, D.L.A.C.S.; Raposo, C.M.O.; Silva, S.M.L.

    2012-01-01

    This study evaluated the influence of different organoclays on morphology of PP/EPDM blends. Two organobentonite (MPH and MPTH), provided by Laboratory of physical chemistry of the Academic Unit of Mining and Geology/UFCG/Campina Grande/PB and a montmorillonite (Cloisite 20A - C20A), provided by Southern Clay Products (Texas/USA) were added to the PP/EPDM polymer blend in order to obtain nanocomposites containing 1 phr of organoclay. The blends of PP/EPDM/organoclay were prepared by melt intercalation process, in an internal mixer coupled to the Haake Torque Rheometer, operating at 180 ° C and 50 rpm for 15min. The samples were characterized by X-ray diffraction and scanning electron microscopy. The results show that the type of organoclay modified the morphology of PP/EPDM blends. (author)

  5. Study of the pp-> np+ reaction at 1.25 GeV with HADES

    CERN Document Server

    Liu, T; Agakishiev, G; Agodi, C; Balanda, A; Bellia, G; Belver, D; Belyaev, A; Blanco, A; Böhmer, M; Boyard, J L; Braun-Munzinger, P; Cabanelas, P; Castro, E; Christ, T; Destefanis, M; Díaz, J; Dohrmann, F; Dybczak, A; Fabbietti, L; Fateev, O; Finocchiaro, P; Fonte, P; Friese, J; Fröhlich, I; Galatyuk, T; Garzón, J A; Gernhäuser, R; Gil, A; Gilardi, C; Golubeva, M; González-Díaz, D; Grosse, E; Guber, F; Heilmann, M; Hennino, T; Holzmann, R; Ierusalimov, A; Iori, I; Ivashkin, A; Jurkovic, M; Kämpfer, B; Kanaki, K; Karavicheva, T; Kirschner, D; Koenig, I; Koenig, W; Kolb, B W; Kotte, R; Kozuch, A; Krása, A; Krížek, F; Krücken, R; Kühn, W; Kugler, A; Kurepin, A; Lamas-Valverde, J; Lang, S; Lange, J S; Lapidus, K; Lopes, L; Lorenz, M; Maier, L; Mangiarotti, A; Marín, J; Markert, J; Metag, V; Michalska, B; Michel, J; Mishra, D; Moriničre, E; Mousa, J; Müntz, C; Naumann, L; Novotny, R; Otwinowski, J; Pachmayer, Y C; Palka, M; Parpottas, Y; Pechenov, V; Pechenova, O; Pérez Cavalcanti, T; Pietraszko, J; Przygoda, W; Ramstein, B; Reshetin, A; Rustamov, A; Sadovsky, A; Salabura, P; Schmah, A; Simon, R; Sobolev, Yu G; Spataro, S; Spruck, B; Ströbele, H; Stroth, J; Sturm, C; Sudol, M; Tarantola, A; Teilab, K; Tlustý, P; Traxler, M; Trebacz, R; Tsertos, H; Veretenkin, I; Wagner, V; Weber, M; Wisniowski, M; Wüstenfeld, J; Yurevich, S; Zanevsky, Y V; Zhou, P; Zumbruch, P

    2010-01-01

    In pp collisions at 1.25 GeV kinetic energy, the HADES collaboration aimed at investigating the di-electron production related to (1232) Dalitz decay ( + ! pe+e−). In order to constrain the models predicting the cross section and the production mechanisms of resonance, the hadronic channels have been measured and studied in parallel to the leptonic channels. The analyses of pp ! np + and pp ! pp 0 channels and the comparison to simulations are presented in this contribution, in particular the angular distributions being sensitive to production and decay. The accurate acceptance corrections have been performed as well, which could be tested in all the phase space region thanks to the high statistic data. These analyses result in an overall agreement with the one- exchange model and previous data.

  6. PP2A: The Achilles Heal in MDS with 5q Deletion

    Directory of Open Access Journals (Sweden)

    David eSallman

    2014-09-01

    Full Text Available Myelodysplastic syndromes (MDS represent a hematologically diverse group of myeloid neoplasms, however, one subtype characterized by an isolated deletion of chromosome 5q (del(5q is pathologically and clinically distinct. Patients with del(5q MDS share biological features that account for the profound hypoplastic anemia and unique sensitivity to treatment with lenalidomide. Ineffective erythropoiesis in del(5q MDS arises from allelic deletion of the ribosomal processing S-14 (RPS14 gene, which leads to MDM2 sequestration with consequent p53 activation and erythroid cell death. Since its approval in 2005, lenalidomide has changed the natural course of the disease. Patients who achieve transfusion independence and/or a cytogenetic response with lenalidomide have a decreased risk of progression to AML and an improved overall survival compared to non-responders. Elucidation of the mechanisms of action of lenalidomide in del(5q MDS has advanced therapeutic strategies for this disease. The selective cytotoxicity of lenalidomide in del(5q clones derives from inhibition of a haplodeficient phosphatase whose catalytic domain is encoded within the common deleted region on chromosome 5q, i.e., protein phosphatase 2A (PP2Acα. PP2A is a highly conserved, dual specificity phosphatase that plays an essential role in regulation of the G2/M checkpoint. Inhibition of PP2Acα results in cell cycle arrest and apoptosis in del(5q cells. Targeted knockdown of PP2Acα using siRNA is sufficient to sensitize non-del(5q clones to lenalidomide. Through its inhibitory effect on PP2A, lenalidomide stabilizes MDM2 to restore p53 degradation in erythroid precursors, with subsequent arrest in G2/M. Unfortunately, the majority of patients with del(5q MDS develop resistance to lenalidomide over time associated with PP2Acα overexpression. Targeted inhibition of PP2A with a more potent inhibitor has emerged as an attractive therapeutic approach for patients with del(5q MDS.

  7. Search for B+ c decays to the ppπ+ final state

    NARCIS (Netherlands)

    Aaij, R.; Abellán Beteta, C.; Adeva, B.; Adinolfi, M.; Ajaltouni, Z.; Akar, S.; Albrecht, J.; Alessio, F.; Alexander, M.; Ali, S.; Alkhazov, G.; Alvarez Cartelle, P.; Alves, A. A.; Amato, S.; Amerio, S.; Amhis, Y.; An, L.; Anderlini, L.; Andreassi, G.; Andreotti, M.; Andrews, J. E.; Appleby, R. B.; Aquines Gutierrez, O.; Archilli, F.; d'Argent, P.; Artamonov, A.; Artuso, M.; Aslanides, E.; Auriemma, G.; Baalouch, M.; Bachmann, S.; Back, J. J.; Badalov, A.; Baesso, C.; Baker, S.; Baldini, W.; Barlow, R. J.; Barschel, C.; Barsuk, S.; Barter, W.; Batozskaya, V.; Battista, V.; Beaucourt, L.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Bel, L. J.; Bellee, V.; Belloli, N.; Belyaev, I.; Ben-Haim, E.; Bencivenni, G.; Benson, S.; Benton, J.; Berezhnoy, A.; Bernet, R.; Bertolin, A.; Betti, F.; Bettler, M. O.; van Beuzekom, M.; Bifani, S.; Billoir, P.; Bird, T.; Birnkraut, A.; Bizzeti, A.; Blake, T.; Blanc, F.; Blouw, J.; Blusk, S.; Bocci, V.; Bondar, A.; Bondar, N.; Bonivento, W.; Borgheresi, A.; Borghi, S.; Borisyak, M.; Borsato, M.; Boubdir, M.; Bowcock, T. J V; Bowen, E.; Bozzi, C.; Braun, S.; Britsch, M.; Britton, T.; Brodzicka, J.; Buchanan, E.; Burr, C.; Bursche, A.; Buytaert, J.; Cadeddu, S.; Calabrese, R.; Calvi, M.; Calvo Gomez, M.; Campana, P.; Campora Perez, D.; Capriotti, L.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carniti, P.; Carson, L.; Carvalho Akiba, K.; Casse, G.; Cassina, L.; Castillo Garcia, L.; Cattaneo, M.; Cauet, Ch; Cavallero, G.; Cenci, R.; Charles, M.; Charpentier, Ph; Chatzikonstantinidis, G.; Chefdeville, M.; Cheung, S. F.; Chrzaszcz, M.; Cid Vidal, X.; Ciezarek, G.; Clarke, P. E L; Clemencic, M.; Cliff, H. V.; Closier, J.; Coco, V.; Cogan, J.; Cogneras, E.; Cogoni, V.; Cojocariu, L.; Collazuol, G.; Collins, P.; Comerma-Montells, A.; Contu, A.; Cook, A.; Coombes, M.; Coquereau, S.; Corti, G.; Corvo, M.; Couturier, B.; Cowan, G. A.; Craik, D. C.; Crocombe, A.; Cruz Torres, M.; Cunliffe, S.; Currie, R.; D'Ambrosio, C.; Dall'Occo, E.; Dalseno, J.; David, P. N Y; Davis, A.; De Aguiar Francisco, O.; De Bruyn, K.; De Capua, S.; De Cian, M.; De Miranda, J. M.; De Paula, L.; De Simone, P.; Dean, C. T.; Decamp, D.; Deckenhoff, M.; Del Buono, L.; Déléage, N.; Demmer, M.; Derkach, D.; Deschamps, O.; Dettori, F.; Dey, B.; Di Canto, A.; Di Ruscio, F.; Dordei, F.; Dorigo, M.; Dosil Suárez, A.; Dovbnya, A.; Dreimanis, K.; Dufour, L.; Dujany, G.; Dungs, K.; Durante, P.; Dzhelyadin, R.; Dziurda, A.; Dzyuba, A.; Easo, S.; Egede, U.; Egorychev, V.; Eidelman, S.; Eisenhardt, S.; Eitschberger, U.; Ekelhof, R.; Eklund, L.; El Rifai, I.; Elsasser, Ch; Ely, S.; Esen, S.; Evans, H. M.; Evans, T.; Falabella, A.; Färber, C.; Farley, N.; Farry, S.; Fay, R.; Fazzini, D.; Ferguson, D.; Fernandez Albor, V.; Ferrari, F.; Ferreira Rodrigues, F.; Ferro-Luzzi, M.; Filippov, S.; Fiore, M.; Fiorini, M.; Firlej, M.; Fitzpatrick, C.; Fiutowski, T.; Fleuret, F.; Fohl, K.; Fontana, M.; Fontanelli, F.; Forshaw, D. C.; Forty, R.; Frei, C.; Frosini, M.; Furfaro, E.; Gallas Torreira, A.; Galli, D.; Gallorini, S.; Gambetta, S.; Gandelman, M.; Gandini, P.; García Pardiñas, J.; Garra Tico, J.; Garrido, L.; Garsed, P. J.; Gascon, D.; Gaspar, C.; Gavardi, L.; Gazzoni, G.; Gerick, D.; Gersabeck, E.; Gersabeck, M.; Gershon, T.; Ghez, Ph; Gianiỳ, S.; Gibson, V.; Girard, O. G.; Giubega, L.; Gligorov, V. V.; Göbel, C.; Golubkov, D.; Golutvin, A.; Gotti, C.; Grabalosa Gándara, M.; Graciani Diaz, R.; Granado Cardoso, L. A.; Graugés, E.; Graverini, E.; Graziani, G.; Grecu, A.; Griffith, P.; Grillo, L.; Grünberg, O.; Gui, B.; Gushchin, E.; Guz, Yu; Gys, T.; Hadavizadeh, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Haines, S. C.; Hall, S.; Hamilton, B.; Hansmann-Menzemer, S.; Harnew, N.; Harnew, S. T.; Harrison, J.; He, J.; Head, T.; Heister, A.; Hennessy, K.; Henrard, P.; Henry, L.; Hernando Morata, J. A.; van Herwijnen, E.; Heß, M.; Hicheur, A.; Hill, D.; Hoballah, M.; Hombach, C.; Hongming, L.; Hulsbergen, W.; Humair, T.; Hushchyn, M.; Hutchcroft, D.; Idzik, M.; Ilten, P.; Jacobsson, R.; Jalocha, J.; Jans, E.; Jawahery, A.; John, M.; Johnson, D.; Jones, C. R.; Joram, C.; Jost, B.; Jurik, N.; Kandybei, S.; Kanso, W.; Karacson, M.; Karbach, T. M.; Karodia, S.; Kecke, M.; Kelsey, M.; Kenyon, I. R.; Kenzie, M.; Ketel, T.; Khairullin, E.; Khanji, B.; Khurewathanakul, C.; Kirn, T.; Klaver, S.; Klimaszewski, K.; Kolpin, M.; Komarov, I.; Koppenburg, P.; Kozeiha, M.; Kravchuk, L.; Kreplin, K.; Kreps, M.; Krokovny, P.; Krzemien, W.; Kucewicz, W.; Kucharczyk, M.; Kudryavtsev, V.; Kuonen, A. K.; Kurek, K.; Kvaratskheliya, T.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lambert, D.; Lanfranchi, G.; Langenbruch, C.; Langhans, B.; Latham, T.; Lazzeroni, C.; Le Gac, R.; van Leerdam, J.; Lees, J. P.; Lefèvre, R.; Leflat, A.; Lefrançois, J.; Lemos Cid, E.; Leroy, O.; Lesiak, T.; Leverington, B.; Likhomanenko, T.; Lindner, R.; Linn, C.; Lionetto, F.; Loh, D.; Longstaff, I.; Lopes, J. H.; Lucchesi, D.; Lucio Martinez, M.; Luo, H.; Lupato, A.; Luppi, E.; Lupton, O.; Lusardi, N.; Lusiani, A.; Lyu, X.; Machefert, F.; Maciuc, F.; Maev, O.; Maguire, K.; Malde, S.; Malinin, A.; Manca, G.; Mancinelli, G.; Manning, P.; Mapelli, A.; Maratas, J.; Marchand, J. F.; Marconi, U.; Marin Benito, C.; Marino, P.; Marks, J.; Martellotti, G.; Martinelli, M.; Martinez Santos, D.; Martinez Vidal, F.; Martins Tostes, D.; Massacrier, L. M.; Massafferri, A.; Matev, R.; Mathad, A.; Mathe, Z.; Matteuzzi, C.; Mauri, A.; Maurin, B.; Mazurov, A.; McCann, M.; McCarthy, J.; McNab, A.; McNulty, R.; Meadows, B.; Meier, F.; Melnychuk, D.; Merk, M.; Merli, A.; Michielin, E.; Milanes, D. A.; Minard, M. N.; Mitzel, D. S.; Molina Rodriguez, J.; Monroy, I. A.; Monteil, S.; Morandin, M.; Morawski, P.; Mordà, A.; Morello, M. J.; Moron, J.; Morris, A. B.; Mountain, R.; Muheim, F.; Müller, V.; Mussini, M.; Muster, B.; Naik, P.; Nakada, T.; Nandakumar, R.; Nandi, A.; Nasteva, I.; Needham, M.; Neri, N.; Neubert, S.; Neufeld, N.; Neuner, M.; Nguyen, A. D.; Nguyen-Mau, C.; Niess, V.; Nieswand, S.; Niet, R.; Nikitin, N.; Nikodem, T.; Novoselov, A.; O'Hanlon, D. P.; Oblakowska-Mucha, A.; Obraztsov, V.; Ogilvy, S.; Okhrimenko, O.; Oldeman, R.; Onderwater, C. J G; Osorio Rodrigues, B.; Otalora Goicochea, J. M.; Otto, A.; Owen, P.; Oyanguren, A.; Palano, A.; Palombo, F.; Palutan, M.; Papanestis, A.; Pappagallo, M.; Pappalardo, L. L.; Pappenheimer, C.; Parker, W.; Parkes, C.; Passaleva, G.; Patel, G. D.; Patrignani, C.; Pearce, A.; Pellegrino, A.; Penso, G.; Pepe Altarelli, M.; Perazzini, S.; Perret, P.; Pescatore, L.; Petridis, K.; Petrolini, A.; Petruzzo, M.; Picatoste Olloqui, E.; Pietrzyk, B.; Pikies, M.; Pinci, D.; Pistone, A.; Piucci, A.; Playfer, S.; Plo Casasus, M.; Poikela, T.; Polci, F.; Poluektov, A.; Polyakov, I.; Polycarpo, E.; Popov, A.; Popov, D.; Popovici, B.; Potterat, C.; Price, E.; Price, J. D.; Prisciandaro, J.; Pritchard, A.; Prouve, C.; Pugatch, V.; Puig Navarro, A.; Punzi, G.; Qian, W.; Quagliani, R.; Rachwal, B.; Rademacker, J. H.; Rama, M.; Ramos Pernas, M.; Rangel, M. S.; Raniuk, I.; Raven, G.; Redi, F.; Reichert, S.; dos Reis, A. C.; Renaudin, V.; Ricciardi, S.; Richards, S.; Rihl, M.; Rinnert, K.; Rives Molina, V.; Rodrigues, A. B.; Rodrigues, E.; Rodriguez Lopez, J. A.; Rodriguez Perez, P.; Rogozhnikov, A.; Roiser, S.; Romanovsky, V.; Romero Vidal, A.; Ronayne, J. W.; Rotondo, M.; Ruf, T.; Ruiz Valls, P.; Saborido Silva, J. J.; Sagidova, N.; Saitta, B.; Salustino Guimaraes, V.; Sanchez Mayordomo, C.; Sanmartin Sedes, B.; Santacesaria, R.; Santamarina Rios, C.; Santimaria, M.; Santovetti, E.; Sarti, A.; Satriano, C.; Satta, A.; Saunders, D. M.; Savrina, D.; Schael, S.; Schindler, H.; Schlupp, M.; Schmelling, M.; Schmelzer, T.; Schmidt, B.; Schneider, O.; Schopper, A.; Schubiger, M.; Schune, M. H.; Schwemmer, R.; Sciascia, B.; Sciubba, A.; Semennikov, A.; Sergi, A.; Serra, N.; Serrano, J.; Sestini, L.; Seyfert, P.; Shapkin, M.; Shapoval, I.; Shcheglov, Y.; Shears, T.; Shekhtman, L.; Shevchenko, V.; Shires, A.; Siddi, B. G.; Silva Coutinho, R.; Silva de Oliveira, L.; Simi, G.; Sirendi, M.; Skidmore, N.; Skwarnicki, T.; Smith, I. T.; Snoek, H.; Sokoloff, M. D.; Soler, F. J P; Soomro, F.; Souza, D.; Souza De Paula, B.; Spaan, B.; Spradlin, P.; Sridharan, S.; Stagni, F.; Stahl, M.; Stahl, S.; Stefkova, S.; Steinkamp, O.; Stenyakin, O.; Stevenson, S.; Stone, S.; Storaci, B.; Stracka, S.; Straticiuc, M.; Straumann, U.; Sutcliffe, W.; Swientek, K.; Swientek, S.; Syropoulos, V.; Szczekowski, M.; Szumlak, T.; T'Jampens, S.; Tayduganov, A.; Tekampe, T.; Tellarini, G.; Teubert, F.; van Tilburg, J.; Tisserand, V.; Tobin, M.; Tolk, S.; Tomassetti, L.; Tonelli, D.; Topp-Joergensen, S.; Tournefier, E.; Tourneur, S.; Trabelsi, K.; Traill, M.; Tresch, M.; Trisovic, A.; Tsaregorodtsev, A.; Tsopelas, P.; Tuning, N.; Ukleja, A.; Ustyuzhanin, A.; Uwer, U.; Vacca, C.; Vagnoni, V.; Valat, S.; Valenti, G.; Vallier, A.; Vazquez Gomez, R.; Vazquez Regueiro, P.; Vázquez Sierra, C.; Vecchi, S.; van Veghel, M.; Velthuis, J. J.; Veltri, M.; Veneziano, G.; Vesterinen, M.; Viaud, B.; Vieira, D.; Vieites Diaz, M.; Vilasis-Cardona, X.; Volkov, V.; Vollhardt, A.; Voong, D.; Vorobyev, A.; Vorobyev, V.; Voß, C.; Waldi, R.; Wallace, C.; Wallace, R.; Ward, D. R.; Watson, N. K.; Websdale, D.; Weiden, A.; Whitehead, M.; Wicht, J.; Wilkinson, G.; Williams, T.; Wilson, F. F.; Wimberley, J.; Wishahi, J.; Wislicki, W.; Witek, M.; Wormser, G.; Wotton, S. A.; Wraight, K.; Wright, S.; Wyllie, K.; Xie, Y.; Yang, Z.; Yu, J.; Yuan, X.; Yushchenko, O.; Zangoli, M.; Zavertyaev, M.; Zhelezov, A.; Zheng, Y.; Zhokhov, A.; Zhong, L.; Zhukov, V.; Zucchelli, S.

    2016-01-01

    A search for the decays of the B+ c meson to pp-π+ is performed for the first time using a data sample corresponding to an integrated luminosity of 3.0 fb-1 collected by the LHCb experiment in pp collisions at centre-of-mass energies of 7 and 8 TeV. No signal is found and an upper limit, at 95%

  8. First Observation of the Rare Purely Baryonic Decay B^{0}→pp[over ¯].

    Science.gov (United States)

    Aaij, R; Adeva, B; Adinolfi, M; Ajaltouni, Z; Akar, S; Albrecht, J; Alessio, F; Alexander, M; Alfonso Albero, A; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves, A A; Amato, S; Amerio, S; Amhis, Y; An, L; Anderlini, L; Andreassi, G; Andreotti, M; Andrews, J E; Appleby, R B; Archilli, F; d'Argent, P; Arnau Romeu, J; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Baalouch, M; Babuschkin, I; Bachmann, S; Back, J J; Badalov, A; Baesso, C; Baker, S; Balagura, V; Baldini, W; Baranov, A; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Baryshnikov, F; Batozskaya, V; Battista, V; Bay, A; Beaucourt, L; Beddow, J; Bedeschi, F; Bediaga, I; Beiter, A; Bel, L J; Beliy, N; Bellee, V; Belloli, N; Belous, K; Belyaev, I; Ben-Haim, E; Bencivenni, G; Benson, S; Beranek, S; Berezhnoy, A; Bernet, R; Berninghoff, D; Bertholet, E; Bertolin, A; Betancourt, C; Betti, F; Bettler, M-O; van Beuzekom, M; Bezshyiko, Ia; Bifani, S; Billoir, P; Birnkraut, A; Bitadze, A; Bizzeti, A; Bjørn, M; Blake, T; Blanc, F; Blouw, J; Blusk, S; Bocci, V; Boettcher, T; Bondar, A; Bondar, N; Bonivento, W; Bordyuzhin, I; Borgheresi, A; Borghi, S; Borisyak, M; Borsato, M; Bossu, F; Boubdir, M; Bowcock, T J V; Bowen, E; Bozzi, C; Braun, S; Britton, T; Brodzicka, J; Brundu, D; Buchanan, E; Burr, C; Bursche, A; Buytaert, J; Byczynski, W; Cadeddu, S; Cai, H; Calabrese, R; Calladine, R; Calvi, M; Calvo Gomez, M; Camboni, A; Campana, P; Campora Perez, D H; Capriotti, L; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carniti, P; Carson, L; Carvalho Akiba, K; Casse, G; Cassina, L; Castillo Garcia, L; Cattaneo, M; Cavallero, G; Cenci, R; Chamont, D; Charles, M; Charpentier, Ph; Chatzikonstantinidis, G; Chefdeville, M; Chen, S; Cheung, S F; Chitic, S-G; Chobanova, V; Chrzaszcz, M; Chubykin, A; Ciambrone, P; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Cogan, J; Cogneras, E; Cogoni, V; Cojocariu, L; Collins, P; Colombo, T; Comerma-Montells, A; Contu, A; Cook, A; Coombs, G; Coquereau, S; Corti, G; Corvo, M; Costa Sobral, C M; Couturier, B; Cowan, G A; Craik, D C; Crocombe, A; Cruz Torres, M; Currie, R; D'Ambrosio, C; Da Cunha Marinho, F; Dall'Occo, E; Dalseno, J; Davis, A; De Aguiar Francisco, O; De Capua, S; De Cian, M; De Miranda, J M; De Paula, L; De Serio, M; De Simone, P; Dean, C T; Decamp, D; Del Buono, L; Dembinski, H-P; Demmer, M; Dendek, A; Derkach, D; Deschamps, O; Dettori, F; Dey, B; Di Canto, A; Di Nezza, P; Dijkstra, H; Dordei, F; Dorigo, M; Dosil Suárez, A; Douglas, L; Dovbnya, A; Dreimanis, K; Dufour, L; Dujany, G; Durante, P; Dzhelyadin, R; Dziewiecki, M; Dziurda, A; Dzyuba, A; Easo, S; Ebert, M; Egede, U; Egorychev, V; Eidelman, S; Eisenhardt, S; Eitschberger, U; Ekelhof, R; Eklund, L; Ely, S; Esen, S; Evans, H M; Evans, T; Falabella, A; Farley, N; Farry, S; Fazzini, D; Federici, L; Ferguson, D; Fernandez, G; Fernandez Declara, P; Fernandez Prieto, A; Ferrari, F; Ferreira Rodrigues, F; Ferro-Luzzi, M; Filippov, S; Fini, R A; Fiore, M; Fiorini, M; Firlej, M; Fitzpatrick, C; Fiutowski, T; Fleuret, F; Fohl, K; Fontana, M; Fontanelli, F; Forshaw, D C; Forty, R; Franco Lima, V; Frank, M; Frei, C; Fu, J; Funk, W; Furfaro, E; Färber, C; Gabriel, E; Gallas Torreira, A; Galli, D; Gallorini, S; Gambetta, S; Gandelman, M; Gandini, P; Gao, Y; Garcia Martin, L M; García Pardiñas, J; Garra Tico, J; Garrido, L; Garsed, P J; Gascon, D; Gaspar, C; Gavardi, L; Gazzoni, G; Gerick, D; Gersabeck, E; Gersabeck, M; Gershon, T; Ghez, Ph; Gianì, S; Gibson, V; Girard, O G; Giubega, L; Gizdov, K; Gligorov, V V; Golubkov, D; Golutvin, A; Gomes, A; Gorelov, I V; Gotti, C; Govorkova, E; Grabowski, J P; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graverini, E; Graziani, G; Grecu, A; Greim, R; Griffith, P; Grillo, L; Gruber, L; Gruberg Cazon, B R; Grünberg, O; Gushchin, E; Guz, Yu; Gys, T; Göbel, C; Hadavizadeh, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hamilton, B; Han, X; Hancock, T H; Hansmann-Menzemer, S; Harnew, N; Harnew, S T; Harrison, J; Hasse, C; Hatch, M; He, J; Hecker, M; Heinicke, K; Heister, A; Hennessy, K; Henrard, P; Henry, L; van Herwijnen, E; Heß, M; Hicheur, A; Hill, D; Hombach, C; Hopchev, P H; Huard, Z C; Hulsbergen, W; Humair, T; Hushchyn, M; Hutchcroft, D; Ibis, P; Idzik, M; Ilten, P; Jacobsson, R; Jalocha, J; Jans, E; Jawahery, A; Jiang, F; John, M; Johnson, D; Jones, C R; Joram, C; Jost, B; Jurik, N; Kandybei, S; Karacson, M; Kariuki, J M; Karodia, S; Kazeev, N; Kecke, M; Kelsey, M; Kenzie, M; Ketel, T; Khairullin, E; Khanji, B; Khurewathanakul, C; Kirn, T; Klaver, S; Klimaszewski, K; Klimkovich, T; Koliiev, S; Kolpin, M; Komarov, I; Kopecna, R; Koppenburg, P; Kosmyntseva, A; Kotriakhova, S; Kozeiha, M; Kravchuk, L; Kreps, M; Krokovny, P; Kruse, F; Krzemien, W; Kucewicz, W; Kucharczyk, M; Kudryavtsev, V; Kuonen, A K; Kurek, K; Kvaratskheliya, T; Lacarrere, D; Lafferty, G; Lai, A; Lanfranchi, G; Langenbruch, C; Latham, T; Lazzeroni, C; Le Gac, R; Leflat, A; Lefrançois, J; Lefèvre, R; Lemaitre, F; Lemos Cid, E; Leroy, O; Lesiak, T; Leverington, B; Li, P-R; Li, T; Li, Y; Li, Z; Likhomanenko, T; Lindner, R; Lionetto, F; Lisovskyi, V; Liu, X; Loh, D; Loi, A; Longstaff, I; Lopes, J H; Lucchesi, D; Lucio Martinez, M; Luo, H; Lupato, A; Luppi, E; Lupton, O; Lusiani, A; Lyu, X; Machefert, F; Maciuc, F; Macko, V; Mackowiak, P; Maddrell-Mander, S; Maev, O; Maguire, K; Maisuzenko, D; Majewski, M W; Malde, S; Malinin, A; Maltsev, T; Manca, G; Mancinelli, G; Manning, P; Marangotto, D; Maratas, J; Marchand, J F; Marconi, U; Marin Benito, C; Marinangeli, M; Marino, P; Marks, J; Martellotti, G; Martin, M; Martinelli, M; Martinez Santos, D; Martinez Vidal, F; Martins Tostes, D; Massacrier, L M; Massafferri, A; Matev, R; Mathad, A; Mathe, Z; Matteuzzi, C; Mauri, A; Maurice, E; Maurin, B; Mazurov, A; McCann, M; McNab, A; McNulty, R; Mead, J V; Meadows, B; Meaux, C; Meier, F; Meinert, N; Melnychuk, D; Merk, M; Merli, A; Michielin, E; Milanes, D A; Millard, E; Minard, M-N; Minzoni, L; Mitzel, D S; Mogini, A; Molina Rodriguez, J; Mombacher, T; Monroy, I A; Monteil, S; Morandin, M; Morello, M J; Morgunova, O; Moron, J; Morris, A B; Mountain, R; Muheim, F; Mulder, M; Müller, D; Müller, J; Müller, K; Müller, V; Naik, P; Nakada, T; Nandakumar, R; Nandi, A; Nasteva, I; Needham, M; Neri, N; Neubert, S; Neufeld, N; Neuner, M; Nguyen, T D; Nguyen-Mau, C; Nieswand, S; Niet, R; Nikitin, N; Nikodem, T; Nogay, A; O'Hanlon, D P; Oblakowska-Mucha, A; Obraztsov, V; Ogilvy, S; Oldeman, R; Onderwater, C J G; Ossowska, A; Otalora Goicochea, J M; Owen, P; Oyanguren, A; Pais, P R; Palano, A; Palutan, M; Papanestis, A; Pappagallo, M; Pappalardo, L L; Parker, W; Parkes, C; Passaleva, G; Pastore, A; Patel, M; Patrignani, C; Pearce, A; Pellegrino, A; Penso, G; Pepe Altarelli, M; Perazzini, S; Perret, P; Pescatore, L; Petridis, K; Petrolini, A; Petrov, A; Petruzzo, M; Picatoste Olloqui, E; Pietrzyk, B; Pikies, M; Pinci, D; Pistone, A; Piucci, A; Placinta, V; Playfer, S; Plo Casasus, M; Polci, F; Poli Lener, M; Poluektov, A; Polyakov, I; Polycarpo, E; Pomery, G J; Ponce, S; Popov, A; Popov, D; Poslavskii, S; Potterat, C; Price, E; Prisciandaro, J; Prouve, C; Pugatch, V; Puig Navarro, A; Pullen, H; Punzi, G; Qian, W; Quagliani, R; Quintana, B; Rachwal, B; Rademacker, J H; Rama, M; Ramos Pernas, M; Rangel, M S; Raniuk, I; Ratnikov, F; Raven, G; Ravonel Salzgeber, M; Reboud, M; Redi, F; Reichert, S; Dos Reis, A C; Remon Alepuz, C; Renaudin, V; Ricciardi, S; Richards, S; Rihl, M; Rinnert, K; Rives Molina, V; Robbe, P; Robert, A; Rodrigues, A B; Rodrigues, E; Rodriguez Lopez, J A; Rodriguez Perez, P; Rogozhnikov, A; Roiser, S; Rollings, A; Romanovskiy, V; Romero Vidal, A; Ronayne, J W; Rotondo, M; Rudolph, M S; Ruf, T; Ruiz Valls, P; Ruiz Vidal, J; Saborido Silva, J J; Sadykhov, E; Sagidova, N; Saitta, B; Salustino Guimaraes, V; Sanchez Mayordomo, C; Sanmartin Sedes, B; Santacesaria, R; Santamarina Rios, C; Santimaria, M; Santovetti, E; Sarpis, G; Sarti, A; Satriano, C; Satta, A; Saunders, D M; Savrina, D; Schael, S; Schellenberg, M; Schiller, M; Schindler, H; Schlupp, M; Schmelling, M; Schmelzer, T; Schmidt, B; Schneider, O; Schopper, A; Schreiner, H F; Schubert, K; Schubiger, M; Schune, M-H; Schwemmer, R; Sciascia, B; Sciubba, A; Semennikov, A; Sepulveda, E S; Sergi, A; Serra, N; Serrano, J; Sestini, L; Seyfert, P; Shapkin, M; Shapoval, I; Shcheglov, Y; Shears, T; Shekhtman, L; Shevchenko, V; Siddi, B G; Silva Coutinho, R; Silva de Oliveira, L; Simi, G; Simone, S; Sirendi, M; Skidmore, N; Skwarnicki, T; Smith, E; Smith, I T; Smith, J; Smith, M; Soares Lavra, L; Sokoloff, M D; Soler, F J P; Souza De Paula, B; Spaan, B; Spradlin, P; Sridharan, S; Stagni, F; Stahl, M; Stahl, S; Stefko, P; Stefkova, S; Steinkamp, O; Stemmle, S; Stenyakin, O; Stepanova, M; Stevens, H; Stone, S; Storaci, B; Stracka, S; Stramaglia, M E; Straticiuc, M; Straumann, U; Sun, J; Sun, L; Sutcliffe, W; Swientek, K; Syropoulos, V; Szczekowski, M; Szumlak, T; Szymanski, M; T'Jampens, S; Tayduganov, A; Tekampe, T; Tellarini, G; Teubert, F; Thomas, E; van Tilburg, J; Tilley, M J; Tisserand, V; Tobin, M; Tolk, S; Tomassetti, L; Tonelli, D; Toriello, F; Tourinho Jadallah Aoude, R; Tournefier, E; Traill, M; Tran, M T; Tresch, M; Trisovic, A; Tsaregorodtsev, A; Tsopelas, P; Tully, A; Tuning, N; Ukleja, A; Usachov, A; Ustyuzhanin, A; Uwer, U; Vacca, C; Vagner, A; Vagnoni, V; Valassi, A; Valat, S; Valenti, G; Vazquez Gomez, R; Vazquez Regueiro, P; Vecchi, S; van Veghel, M; Velthuis, J J; Veltri, M; Veneziano, G; Venkateswaran, A; Verlage, T A; Vernet, M; Vesterinen, M; Viana Barbosa, J V; Viaud, B; Vieira, D; Vieites Diaz, M; Viemann, H; Vilasis-Cardona, X; Vitti, M; Volkov, V; Vollhardt, A; Voneki, B; Vorobyev, A; Vorobyev, V; Voß, C; de Vries, J A; Vázquez Sierra, C; Waldi, R; Wallace, C; Wallace, R; Walsh, J; Wang, J; Ward, D R; Wark, H M; Watson, N K; Websdale, D; Weiden, A; Whitehead, M; Wicht, J; Wilkinson, G; Wilkinson, M; Williams, M; Williams, M P; Williams, M; Williams, T; Wilson, F F; Wimberley, J; Winn, M; Wishahi, J; Wislicki, W; Witek, M; Wormser, G; Wotton, S A; Wraight, K; Wyllie, K; Xie, Y; Xu, Z; Yang, Z; Yang, Z; Yao, Y; Yin, H; Yu, J; Yuan, X; Yushchenko, O; Zarebski, K A; Zavertyaev, M; Zhang, L; Zhang, Y; Zhelezov, A; Zheng, Y; Zhu, X; Zhukov, V; Zonneveld, J B; Zucchelli, S

    2017-12-08

    The first observation of the decay of a B^{0} meson to a purely baryonic final state, B^{0}→pp[over ¯], is reported. The proton-proton collision data sample used was collected with the LHCb experiment at center-of-mass energies of 7 and 8 TeV and corresponds to an integrated luminosity of 3.0  fb^{-1}. The branching fraction is determined to be B(B^{0}→pp[over ¯])=(1.25±0.27±0.18)×10^{-8}, where the first uncertainty is statistical and the second systematic. The decay mode B^{0}→pp[over ¯] is the rarest decay of the B^{0} meson observed to date. The decay B_{s}^{0}→pp[over ¯] is also investigated. No signal is seen and the upper limit B(B_{s}^{0}→pp[over ¯])<1.5×10^{-8} at 90% confidence level is set on the branching fraction.

  9. Adsorption and desorption of plant growth regulator 14C-PP333 in various soils

    International Nuclear Information System (INIS)

    Yu Fengyi; Zhang Ping; Yang Xiu

    1995-01-01

    Adsorption, desorption and residue of 14 C-PP333 with 4 concentrations in various soils were studied by radioactive isotopic tracer. The results showed that the adsorption rates in 6 soils were different. The lowest adsorption rate of fluvo-aquatic soil from Shanxi was 15.22%, the highest adsorption rate of black soil from Heilongjiang was 22.53%. The relation between the C.E.C., O.M. and adsorption rate in soil was correlative. Adsorption rate in soil increased with an increase in C.E.C.. 14 C-PP3333 adsorbed in 6 soils could be desorbed by water. The desorption rate in soils was high. There is residue of 14 C-PP333 in soil desorbed by water. There was a negative relationship between the residue amount and the adsorption rate in soil. Easy desorption of PP333 adsorbed in soil showed that PP333 was movable and diffusible in soil and had influence on agro-ecosystem

  10. Physicochemical Characterization and Skin Permeation of Cationic Transfersomes Containing the Synthetic Peptide PnPP-19.

    Science.gov (United States)

    Almeida, Flavia De Marco; Silva, Carolina Nunes; de Araujo Lopes, Savia Caldeira; Santos, Daniel Moreira; Torres, Fernanda Silva; Cardoso, Felipe Lima; Martinelli, Patricia Massara; da Silva, Elizabeth Ribeiro; de Lima, Maria Elena; Miranda, Lucas Antonio Ferreira; Oliveira, Monica Cristina

    2018-01-08

    PnPP-19 is a 19-amino-acid synthetic peptide previously described as a novel drug for the treatment of erectile dysfunction. The aim of this work was to evaluate the physicochemical properties of cationic transfersomes containing PnPP-19 and the skin permeation of free PnPP-19 and PnPP-19-loaded transfersomes. Three different liposomal preparation methods were evaluated. Cationic transfersomes contained egg phosphatidyl choline: stearylamine (9:1 w/w) and Tween 20 (84.6:15.4 lipid:Tween, w/w). Lipid concentration varied from 20 to 40 mM. We evaluated the entrapment percentage, mean diameter, zeta potential and stability at 4 oC of the formulations. The skin permeation assays were performed with abdominal human skin using Franz diffusion cell with 3 cm2 diffusion area at 32 oC and a fluorescent derivative of the peptide, containing 5-TAMRA, bound to PnPP-19 C-terminal region, where an extra lysine was inserted. Our results showed variable entrapment efficiencies, from 6% to 30%, depending on the preparation method and the lipid concentration used. The reverse phase evaporation method using a total lipid concentration equal to 40 mM led to the best entrapment percentage (30.2 + 4.5%). Free PnPP-19 was able to permeate skin at a rate of 10.8 ng/cm2/h. However, PnPP-19 was specifically hydrolyzed by skin proteases, generating a fragment of 15 amino acid residues. Encapsulated PnPP-19 permeated the skin at a rate of 19.8 ng/cm2/h. The encapsulation of PnPP-19 in cationic transfersomes protected the peptide from degradation, favoring its topical administration. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  11. Influência do teor de polipropileno modificado com anidrido maleico nas propriedades do nanocompósito PP/EPDM/argila organofílica Influence from the concentration of interfacial agent on the properties of PP/EPDM/organoclay nanocomposites

    Directory of Open Access Journals (Sweden)

    Fernanda C. F. Braga

    2012-01-01

    Full Text Available Neste trabalho foram obtidos nanocompósitos de elastômeros termoplásticos à base de PP/EPDM/argila organofílica pela técnica de intercalação no estado fundido em câmara interna de mistura. Foram preparados concentrados de PP-MA (agente interfacial e Claytone 40 (argila organofílica nas proporções de 1:1, 2:1 e 3:1 que posteriormente foram adicionados na matriz PP/EPDM, previamente preparada, mantendo o teor de argila fixo em 5% (em massa. Foram investigadas as propriedades mecânicas de módulo elástico, tração e alongamento na ruptura, reologia e morfologia, a fim de estabelecer a influência da razão PP-MA/argila organofílica no comportamento dos nanocompósitos. Os resultados mostraram que a adição de teores crescentes de PP-MA melhorou a dispersão da argila organofílica na matriz de PP/EPDM. Conforme revelado pela difração de raio X e confirmados pela reometria foram obtidos nanocompósitos com estruturas mistas intercaladas e esfoliadas, que resultaram em maiores valores de módulo e deformação na ruptura.In this work, nanocomposites were prepared with PP/EPDM thermoplastic elastomer and organoclay by melt intercalation in an internal mixture chamber. Masterbatches composed of PP-MA/organoclay in proportions of 1:1, 2:1 and 3:1 were prepared and further added to a PP/EPDM thermoplastic elastomer, keeping the clay content fixed at 5% (by weight. The tensile properties, rheology and the morphology (organoclay dispersion, crystalline structure and crystallinity degree of nanocomposites were studied to establish the influence of the PP-MA/Organoclay ratio in the system. The results showed that the addition of increasing levels of PP-MA improved the dispersion of organoclay in the PP/EPDM matrix. As revealed in x-ray diffraction and confirmed by rheology measurements nanocomposites were obtained with mixed intercalated and exfoliated structures, resulting in higher tensile modulus and elongation at break.

  12. PP/APLP2 Family of Kunitz Serine Proteinase Inhibitors Regulate Cerebral Thrombosis

    Science.gov (United States)

    Xu, Feng; Previti, Mary Lou; Nieman, Marvin T.; Davis, Judianne; Schmaier, Alvin H.; Van Nostrand, William E.

    2009-01-01

    The amyloid β-protein precursor (AβPP) is best recognized as the precursor to the Aβ peptide that accumulates in the brains of patients with Alzheimer’s disease, but less is known about its physiological functions. Isoforms of AβPP that contain a Kunitz-type serine proteinase inhibitor (KPI) domain are expressed in brain and, outside the CNS, in circulating blood platelets. Recently, we showed that KPI-containing forms of AβPP regulates cerebral thrombosis in vivo (Xu et al., 2005 Proc. Natl. Acad. Sci. USA 102:18135–18140; Xu et al. 2007 Stroke 38:2598–2601). Amyloid precursor like protein-2 (APLP2), a closely related homolog to AβPP, also possesses a highly conserved KPI domain. Virtually nothing is known of its function. Here we show that APLP2 also regulates cerebral thrombosis risk. Recombinant purified KPI domains of AβPP and APLP2 both inhibit the plasma clotting in vitro. In a carotid artery thrombosis model both AβPP−/− and APLP2−/− mice exhibit similar significantly shorter times to vessel occlusion compared with wild-type mice indicating a pro-thrombotic phenotype. Similarly, in an experimental model of intracerebral hemorrhage both AβPP−/− and APLP2−/− mice produce significantly smaller hematomas with reduced brain hemoglobin content compared with wild-type mice. Together, these results indicate that AβPP and APLP2 share overlapping anticoagulant functions with regard to regulating thrombosis after cerebral vascular injury. PMID:19403832

  13. Could we understand the 1 D2 → pp-bar charmonium decay?

    International Nuclear Information System (INIS)

    Anselmino, M.; Negrao, M.R.

    1994-01-01

    Massless perturbative QCD forbids, at leading order, the exclusive annihilation of proton-antiproton into charmonium states, which, however, have been observed in the pp-bar channel, indicating the significance of higher order and non perturbative effects in the few GeV energy region. The most well known cases are those of the 1 S 0 (η c ) and the 1P 1 . We consider here the 1 D 2 state, whose coupling to pp-bar in equally forbidden in p QCD, and study several possible non perturbative contributions. It turns out that the observation of the pp-bar → 1 D 2 process would be very intriguing indeed. (author)

  14. PP: A graphics post-processor for the EQ6 reaction path code

    International Nuclear Information System (INIS)

    Stockman, H.W.

    1994-09-01

    The PP code is a graphics post-processor and plotting program for EQ6, a popular reaction-path code. PP runs on personal computers, allocates memory dynamically, and can handle very large reaction path runs. Plots of simple variable groups, such as fluid and solid phase composition, can be obtained with as few as two keystrokes. Navigation through the list of reaction path variables is simple and efficient. Graphics files can be exported for inclusion in word processing documents and spreadsheets, and experimental data may be imported and superposed on the reaction path runs. The EQ6 thermodynamic database can be searched from within PP, to simplify interpretation of complex plots

  15. Effect of injection molding parameters on nanofillers dispersion in masterbatch based PP-clay nanocomposites

    OpenAIRE

    J. Soulestin; J. J. Rajesh; M. F. Lacrampe; P. Krawczak

    2012-01-01

    The effect of injection molding parameters (screw rotational speed, back pressure, injec-tion flow rate and holding pressure) on the nanofiller dispersion of melt-mixed PP/clay nanocomposites was investigated. The nanocomposites containing 4 wt% clay were obtained by dilution of a PP/clay masterbatch into a PP matrix. The evaluation of the dispersion degree was obtained from dynamic rheological measurements. The storage modulus and complex viscosity exhibit significant dependence on the injec...

  16. Physics at the FCC-hh, a 100 TeV pp collider

    CERN Document Server

    2017-01-01

    A 100 TeV pp collider is under consideration, by the high-energy physics community, as an important step for the future development of our field, following the completion of the LHC and High-luminosity LHC physics programmes. In particular, CERN is considering 100 TeV pp collisions as the key target of a Future Circular Collider facility, built around a 100 km tunnel and designed to deliver pp, e+e- and ep collisions, in addition to a programme with heavy ion beams and with the injector complex. CERN is coordinating an international study tasked with the completion, by the end of 2018, of a Conceptual Design Report (CDR) for this facility. This document presents the first results of the assessment of the physics potential of the hadronic part of this research programme (FCC-hh).

  17. GridPP - Preparing for LHC Run 2 and the Wider Context

    Science.gov (United States)

    Coles, Jeremy

    2015-12-01

    This paper elaborates upon the operational status and directions within the UK Computing for Particle Physics (GridPP) project as it approaches LHC Run 2. It details the pressures that have been gradually reshaping the deployed hardware and middleware environments at GridPP sites - from the increasing adoption of larger multicore nodes to the move towards alternative batch systems and cloud alternatives - as well as changes being driven by funding considerations. The paper highlights work being done with non-LHC communities and describes some of the early outcomes of adopting a generic DIRAC based job submission and management framework. The paper presents results from an analysis of how GridPP effort is distributed across various deployment and operations tasks and how this may be used to target further improvements in efficiency.

  18. Evaluation of the degree of dispersion of organoclay on nanocomposites with PP/EPDM; Avaliacao do grau de dispersao de argilas organofilicas em nanocompositos de PP/EPDM

    Energy Technology Data Exchange (ETDEWEB)

    Braga, F.C.F.; Oliveira, M.G., E-mail: fernanda.braga@int.gov.b [Instituto Nacional de Tecnologia (DPCM/INT), Rio de Janeiro, RJ (Brazil). Div. de Processamento e Caracterizacao de Materiais; Furtado, C.R.G. [Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ (Brazil)

    2010-07-01

    Nanocomposites of thermoplastic elastomer (TPE) composed by PP/EPDM 1/1 blend and organoclay were obtained by the melt intercalation in an internal chamber mix. Initially, a masterbatch of maleinized polypropylene (PP-MA) and clay modified with alkyl ammonium salt in the ratio 3:1 was prepared, and then, added to TPE matrix to obtain loads of 2,5; 5 and 7 wt% of clay in the nanocomposite. The dispersion degree of clay in TPE matrix was evaluated by X-ray diffraction and parallel plate rheometry. The intercalation/exfoliate degree or the degree of dispersion varied with clay content, as observed by X-ray diffraction. This behavior was confirmed by the profile of the curves of elastic modulus versus frequency, which presented different slopes in the region of low frequency, due to the presence of clay and PP-MA. (author)

  19. Overcoring rock stress measurements in drillholes ONK-PP169 and ONK-PP170 Olkiluoto

    International Nuclear Information System (INIS)

    Berg, S.; Sjoeberg, J.

    2009-03-01

    Three-dimensional overcoring rock stress measurements were conducted in drillholes ONK-PP169 and ONK-PP170 at the 230 m depth level in the ONKALO site ramp. The measurements were performed during the spring of 2008. The objective of the measurements was to obtain better understanding of the in situ stress field for the measured depth levels. Another objective was to increase the confidence and reliability and to diminish the uncertainties concerning the state of stress at shallow depth of ONKALO. Due to problems with bonding of strain gauges, which may have been caused by a thin layer/coating of unknown material on the pilot hole wall, stress measurements results were only achieved in drillhole ONK-PP170 at -230 m level. The initial plan was to conduct measurements at three depth levels, -120 m, -180 m and -220 m levels, in the ONKALO ramp. Two (2) of the conducted measurements could be rated as successful (rating a) two (2) measurement were partly successful (rating b). The results from the measurements assuming isotropic condition, the major principal stress is plunging between 18deg and 35deg and trending between S and WSW. Stress magnitudes (for σ 1 ) varied between 12 and 16 MPa except for test 2:3:3 where a much higher value (47 MPa) was obtained. The orientation of the major principal stress are similar for test 2:3:3 and 2:4:3 (WSW), but are different from the orientation of the major principal stress for test 2:5:1 and 2:6:1 (S). Likewise, the horizontal stresses have the highest values for test 2:3:3 but in this case the orientation is similar to test 2:5:1 and 2:4:3. The horizontal stress magnitudes of test 2:4:3, 2:5:1 and 2:6:1 are similar but the orientation for test 2:6:1 are different from the other three tests. The results from two of the measurements assuming transversely isotropic conditions, the major principal stress is 12.3 MPa and 12.7 MPa, trending WSW and S, plunging 30 deg. (orig.)

  20. Non-self-adjoint Schrödinger operators with nonlocal one-point interactions

    Czech Academy of Sciences Publication Activity Database

    Kuzhel, S.; Znojil, Miloslav

    2017-01-01

    Roč. 11, č. 4 (2017), s. 923-944 ISSN 1735-8787 R&D Projects: GA ČR GA16-22945S Institutional support: RVO:61389005 Keywords : 1-dimensional Schrodinger operator * nonlocal one-point interactions * boundary triplet Subject RIV: BE - Theoretical Physics OBOR OECD: Atomic, molecular and chemical physics (physics of atoms and molecules including collision, interaction with radiation, magnetic resonances, Mössbauer effect) Impact factor: 0.833, year: 2016

  1. Admissible perturbations and false instabilities in PT-symmetric quantum systems

    Czech Academy of Sciences Publication Activity Database

    Znojil, Miloslav

    2018-01-01

    Roč. 97, č. 3 (2018), č. článku 032114. ISSN 2469-9926 R&D Projects: GA ČR GA16-22945S Institutional support: RVO:61389005 Keywords : quantum theory * states * Hilbert spaces Subject RIV: BE - Theoretical Physics OBOR OECD: Atomic, molecular and chemical physics (physics of atoms and molecules including collision, interaction with radiation, magnetic resonances, Mössbauer effect) Impact factor: 2.925, year: 2016

  2. Hermitian-to-quasi-Hermitian quantum phase transitions

    Czech Academy of Sciences Publication Activity Database

    Znojil, Miloslav

    Roč. 97, č. 4 ( 2018 ), č. článku 042117. ISSN 2469-9926 R&D Projects: GA ČR GA16-22945S Institutional support: RVO:61389005 Keywords : quantum phase transition * PT-symmetric * Herimiticity Subject RIV: BE - Theoretical Physics OBOR OECD: Atomic, molecular and chemical physics (physics of atoms and molecules including collision, interaction with radiation, magnetic resonances, Mössbauer effect) Impact factor: 2.925, year: 2016

  3. Problem of the coexistence of several non-Hermitian observables in PT -symmetric quantum mechanics

    Czech Academy of Sciences Publication Activity Database

    Znojil, Miloslav; Semorádová, Iveta; Růžička, František; Moulla, H.; Leghrib, I.

    2017-01-01

    Roč. 95, č. 4 (2017), č. článku 042122. ISSN 2469-9926 R&D Projects: GA ČR GA16-22945S Institutional support: RVO:61389005 Keywords : operators * Hilbert space * non-Hermitian Subject RIV: BE - Theoretical Physics OBOR OECD: Atomic, molecular and chemical physics (physics of atoms and molecules including collision, interaction with radiation, magnetic resonances, Mössbauer effect) Impact factor: 2.925, year: 2016

  4. Bound states emerging from below the continuum in a solvable PT-symmetric discrete Schrodinger equation

    Czech Academy of Sciences Publication Activity Database

    Znojil, Miloslav

    2017-01-01

    Roč. 96, č. 1 (2017), č. článku 012127. ISSN 2469-9926 R&D Projects: GA ČR GA16-22945S Institutional support: RVO:61389005 Keywords : non-Hermitian * PT symmetric * bound states Subject RIV: BE - Theoretical Physics OBOR OECD: Atomic, molecular and chemical physics (physics of atoms and molecules including collision, interaction with radiation, magnetic resonances, Mössbauer effect) Impact factor: 2.925, year: 2016

  5. Schrodinger Equations with Logarithmic Self-Interactions: From Antilinear PT-Symmetry to the Nonlinear Coupling of Channels

    Czech Academy of Sciences Publication Activity Database

    Znojil, Miloslav; Růžička, František; Zloshchastiev, K. G.

    2017-01-01

    Roč. 9, č. 8 (2017), č. článku 165. ISSN 2073-8994 R&D Projects: GA ČR GA16-22945S Institutional support: RVO:61389005 Keywords : PT symmetry * nonlinear Schrodinger equations * logarithmic nonlinearities Subject RIV: BE - Theoretical Physics OBOR OECD: Atomic, molecular and chemical physics ( physics of atoms and molecules including collision, interaction with radiation, magnetic resonances, Mössbauer effect) Impact factor: 1.457, year: 2016

  6. Beauty baryons produced in pp interactions

    International Nuclear Information System (INIS)

    Fridman, A.

    1996-01-01

    For pp interactions, we discuss the beauty-baryon (N b ), production and decay, using cross-section estimates at a c.m. energy corresponding to the LHC project (√s ≅ 14 TeV). The polarization measurement of N b as well as the search for CP violation effects in their decays is discussed. (orig.)

  7. Triple-differential cross sections of the (π+/,pp) reaction on lithium isotopes

    International Nuclear Information System (INIS)

    Rieder, R.; Barnes, P.D.; Bassalleck, B.

    1985-01-01

    The (π + ,pp) reactions on 6 Li and 7 Li have been studied at T/sub π/ = 59.4 MeV with high resolution. The first triple-differential cross sections for these reactions are presented. The data are fitted to a T-matrix and compared to the π + d → pp reaction. A model in which the pion is absorbed on a 3 S 1 (pn) pair in the lithium nucleus describes many features of the data very well. An extrapolation of our data into unmeasured regions of phase space suggests that about 60% of the pion absorption cross section on 6 Li at 59.4 MeV goes into the (π + ,pp) channel. One surprising feature of the data is that the 6 Li(π + ,pp) 4 He (2 - ) transition at 22.1 MeV excitation is strongly populated, similar to what is observed in the 6 Li(d,α) 4 He reaction. This transition involves removing one nucleon from the 1p shell and one from the 1s shell. 25 refs., 15 figs., 3 tabs

  8. Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer.

    Science.gov (United States)

    Álvarez-Fernández, Mónica; Sanz-Flores, María; Sanz-Castillo, Belén; Salazar-Roa, María; Partida, David; Zapatero-Solana, Elisabet; Ali, H Raza; Manchado, Eusebio; Lowe, Scott; VanArsdale, Todd; Shields, David; Caldas, Carlos; Quintela-Fandino, Miguel; Malumbres, Marcos

    2017-12-11

    PP2A is a major tumor suppressor whose inactivation is frequently found in a wide spectrum of human tumors. In particular, deletion or epigenetic silencing of genes encoding the B55 family of PP2A regulatory subunits is a common feature of breast cancer cells. A key player in the regulation of PP2A/B55 phosphatase complexes is the cell cycle kinase MASTL (also known as Greatwall). During cell division, inhibition of PP2A-B55 by MASTL is required to maintain the mitotic state, whereas inactivation of MASTL and PP2A reactivation is required for mitotic exit. Despite its critical role in cell cycle progression in multiple organisms, its relevance as a therapeutic target in human cancer and its dependence of PP2A activity is mostly unknown. Here we show that MASTL overexpression predicts poor survival and shows prognostic value in breast cancer patients. MASTL knockdown or knockout using RNA interference or CRISPR/Cas9 systems impairs proliferation of a subset of breast cancer cells. The proliferative function of MASTL in these tumor cells requires its kinase activity and the presence of PP2A-B55 complexes. By using a new inducible CRISPR/Cas9 system in breast cancer cells, we show that genetic ablation of MASTL displays a significant therapeutic effect in vivo. All together, these data suggest that the PP2A inhibitory kinase MASTL may have both prognostic and therapeutic value in human breast cancer.

  9. Meson resonances and glueballs: theoretical review and relevance to PP at LEAR

    International Nuclear Information System (INIS)

    Barnes, T.

    1982-05-01

    Some theoretical ideas about the meson spectrum are reviewed and lessons which may be learned about it in PP-bar annihilation are considered. Experimental questions which, if answered, would have the largest impact on the present understanding of quark and gluon interactions are noted. Conventional qq-bar mesons as treated in potential models, concentrating on the familiar cc-bar systems, are reviewed. The exciting possibility is discussed of detecting constituent gluons in PP-bar annihilations, in gg states - which may already have been detected in e + e - and PP-bar, as will be seen and in the exotic Jsup(PC) 'hermaphrodite' states qq-bar, for which there is currently no experimental evidence. (author)

  10. Systems and Control Engineering

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 4; Issue 5. Systems and Control Engineering - Control Systems-Analysis and Design. A Rama Kalyan J R Vengateswaran. General Article Volume 4 Issue 5 May 1999 pp 88-94 ...

  11. Molecular characterization of a phloem-specific gene encoding the filament protein, phloem protein 1 (PP1), from Cucurbita maxima.

    Science.gov (United States)

    Clark, A M; Jacobsen, K R; Bostwick, D E; Dannenhoffer, J M; Skaggs, M I; Thompson, G A

    1997-07-01

    Sieve elements in the phloem of most angiosperms contain proteinaceous filaments and aggregates called P-protein. In the genus Cucurbita, these filaments are composed of two major proteins: PP1, the phloem filament protein, and PP2, the phloem lactin. The gene encoding the phloem filament protein in pumpkin (Cucurbita maxima Duch.) has been isolated and characterized. Nucleotide sequence analysis of the reconstructed gene gPP1 revealed a continuous 2430 bp protein coding sequence, with no introns, encoding an 809 amino acid polypeptide. The deduced polypeptide had characteristics of PP1 and contained a 15 amino acid sequence determined by N-terminal peptide sequence analysis of PP1. The sequence of PP1 was highly repetitive with four 200 amino acid sequence domains containing structural motifs in common with cysteine proteinase inhibitors. Expression of the PP1 gene was detected in roots, hypocotyls, cotyledons, stems, and leaves of pumpkin plants. PP1 and its mRNA accumulated in pumpkin hypocotyls during the period of rapid hypocotyl elongation after which mRNA levels declined, while protein levels remained elevated. PP1 was immunolocalized in slime plugs and P-protein bodies in sieve elements of the phloem. Occasionally, PP1 was detected in companion cells. PP1 mRNA was localized by in situ hybridization in companion cells at early stages of vascular differentiation. The developmental accumulation and localization of PP1 and its mRNA paralleled the phloem lactin, further suggesting an interaction between these phloem-specific proteins.

  12. A sample of high multiplicity pp reactions at 19 GeV/c

    International Nuclear Information System (INIS)

    Allan, J.; Blomqvist, G.

    1976-02-01

    This report describes the experimental procedure used in obtaining samples of high muliplicity pp reactions at 19 GeV/c. Various methods to improve the quality of the samples are tested. The analysis is part of the general study of pp collisions at 19 GeV/c which is performed within the Scandinavian Bubble Chamber Collaboration. (Auth.)

  13. A novel tetratricopeptide repeat (TPR containing PP5 serine/threonine protein phosphatase in the malaria parasite, Plasmodium falciparum

    Directory of Open Access Journals (Sweden)

    Adams Brian

    2001-11-01

    Full Text Available Abstract Background The malarial parasite, Plasmodium falciparum (Pf, is responsible for nearly 2 million deaths worldwide. However, the mechanisms of cellular signaling in the parasite remain largely unknown. Recent discovery of a few protein kinases and phosphatases point to a thriving reversible phosphorylation system in the parasite, although their function and regulation need to be determined. Results We provide biochemical and sequence evidence for a protein serine/threonine phosphatase type PP5 in Plasmodium falciparum, and named it PfPP5. The 594-amino acid polypeptide was encoded by a 1785 nucleotide long intronless gene in the parasite. The recombinant protein, expressed in bacteria, was indistinguishable from native PfPP5. Sequencing comparison indicated that the extra-long N-terminus of PfPP5 outside the catalytic core contained four tetratricopeptide repeats (TPRs, compared to three such repeats in other PP5 phosphatases. The PfPP5 N-terminus was required for stimulation of the phosphatase activity by polyunsaturated fatty acids. Co-immunoprecipitation demonstrated an interaction between native PfPP5 and Pf heat shock protein 90 (hsp90. PfPP5 was expressed in all the asexual erythrocytic stages of the parasite, and was moderately sensitive to okadaic acid. Conclusions This is the first example of a TPR-domain protein in the Apicomplexa family of parasites. Since TPR domains play important roles in protein-protein interaction, especially relevant to the regulation of PP5 phosphatases, PfPP5 is destined to have a definitive role in parasitic growth and signaling pathways. This is exemplified by the interaction between PfPP5 and the cognate chaperone hsp90.

  14. IViPP: A Tool for Visualization in Particle Physics

    Science.gov (United States)

    Tran, Hieu; Skiba, Elizabeth; Baldwin, Doug

    2011-10-01

    Experiments and simulations in physics generate a lot of data; visualization is helpful to prepare that data for analysis. IViPP (Interactive Visualizations in Particle Physics) is an interactive computer program that visualizes results of particle physics simulations or experiments. IViPP can handle data from different simulators, such as SRIM or MCNP. It can display relevant geometry and measured scalar data; it can do simple selection from the visualized data. In order to be an effective visualization tool, IViPP must have a software architecture that can flexibly adapt to new data sources and display styles. It must be able to display complicated geometry and measured data with a high dynamic range. We therefore organize it in a highly modular structure, we develop libraries to describe geometry algorithmically, use rendering algorithms running on the powerful GPU to display 3-D geometry at interactive rates, and we represent scalar values in a visual form of scientific notation that shows both mantissa and exponent. This work was supported in part by the US Department of Energy through the Laboratory for Laser Energetics (LLE), with special thanks to Craig Sangster at LLE.

  15. Measurement of long-range correlations in pp collisions characterized by presence of a Z-boson

    CERN Document Server

    Milov, Alexander; The ATLAS collaboration

    2017-01-01

    Recent measurements of correlations between two particles separated in pesudorapidity and azimuthal angles have shown striking similarities between results obtained in pp, and in p+A and A+A collision systems. In pp collision system, unlike in the p+A and A+A systems, the strength of the correlations quantified by the anisotropy parameter $v_2$ does not show any dependence on the charged-particle multiplicity. Recent theoretical models suggest that this can be due to lack of correlation between the charged-particle multiplicity and the impact parameter of the pp collision. An independent handle on the impact parameter can be obtained by requiring the presence of a hard-scattering process in the collision. This talk presents the first measurement of two-particle correlations in pp collisions with a Z boson identified via its dimuon decay channel. The analysis uses ATLAS data recorded under nominal pp luminosities, and a procedure to correct for contribution of the tracks coming from pileup vertices is used. Th...

  16. The relationship between the violet pigment PP-V production and intracellular ammonium level in Penicillium purpurogenum.

    Science.gov (United States)

    Kojima, Ryo; Arai, Teppei; Matsufuji, Hiroshi; Kasumi, Takafumi; Watanabe, Taisuke; Ogihara, Jun

    2016-12-01

    Penicillium purpurogenum is the fungus that produces an azaphilone pigment. However, details about the pigment biosynthesis pathway are unknown. The violet pigment PP-V is the one of the main pigments biosynthesized by this fungus. This pigment contains an amino group in a pyran ring as its core structure. We focused on this pigment and examined the relationship between intracellular ammonium concentration and pigment production using glutamine as a nitrogen source. The intracellular ammonium level decreased about 1.5-fold in conditions favoring PP-V production. Moreover, P. purpurogenum was transferred to medium in which it commonly produces the related pigment PP-O after cultivating it in the presence or absence of glutamine to investigate whether this fungus biosynthesizes PP-V using surplus ammonium in cells. Only mycelia cultured in medium containing 10 mM glutamine produced the violet pigment, and simultaneously intracellular ammonium levels decreased under this condition. From comparisons of the amount of PP-V that was secreted with quantity of surplus intracellular ammonium, it is suggested that P. purpurogenum maintains ammonium homeostasis by excreting waste ammonium as PP-V.

  17. Penerapan Sistem Akuntansi Instansi Berbasis Akrual sebagai Implementasi PP No. 71 Tahun 2010 pada Politeknik Negeri Pontianak

    OpenAIRE

    Theresia Siwi Kartikawati 3), Sari Zawitri 1) Ninik Kurniasih 2)

    2015-01-01

    The government regulation (PP) number 71 year 2010 is a new regulation standard of accounting in the public sector. The new regulation standard that inspiring the writers to the research title: Penerapan Sistem Akuntansi Instansi Berbasis Akrual sebagai Implementasi PP nomor 71 tahun 2010 pada Politeknik Negeri Pontianak. The Problems are formulated as (1) The changes of institutional accounting system (SAI) PP 24 year 2005 into PP 71 year 2010 or cash toward accrual into accrual basis? (2) H...

  18. Digitaalisen markkinoinnin suunnitelma : Case NäppäräNäppi

    OpenAIRE

    Komulainen, Pia

    2017-01-01

    Toiminnallisessa opinnäytetyössä laadittiin digitaalisen markkinoinnin suunnitelma NäppäräNäpille, joka on askartelun erikoisliike Iisalmessa. Digitaalinen markkinointi on muuttanut yritysten markkinointitoimenpiteitä ja se tarjoaa perinteisiä markkinoinnin kanavia edullisempia vaihtoehtoja. Digitaaliset kanavat kuten sosiaalinen media, verkkosivut ja blogi ovat tehokkaita ja moderneja työkaluja NäppäräNäpin markkinoinille. Työn tavoitteena oli selvittää, digitaalinen markkinointi on, mit...

  19. Study of the Mesons Produced Centrally in the Reaction $pp \\rightarrow pp + X^{0}$ and $\\pi^{+}p \\rightarrow \\pi^{+}p + X^{0}$ at 85 GeV/c

    CERN Multimedia

    2002-01-01

    The basic aim of the experiment, similar to WA76, is to undertake a detailed study of the mesonic system (X|0) produced centrally (X^F~=~0) in the exclusive reactions (@p|-/p)p~@A~(@p|-/p)~X|0p at 300 GeV/c. Many decay modes of X|0, e.g. @p|+@p|-, @p|+@p|-@p|0, 2@p|+2@p|-, 2@p|+2@p|-@p|0, @h|0@p|+@p|-, @w|0@p|+@p|-, K|+K|-, K|+K|-@p|0, K|+K^1|0@p|-~+~c.c., K|+K|-@p|+@p|-, K^1|0K^1|0, @h|0@h|0, @*p, etc. will be identified. A specific aim of the proposal is to see how the meson production observed at 85 GeV/c changes with energy and in so doing to search for evidence of mesons which are strongly coupled to glue. \\\\ \\\\ The experiment uses the OMEGA Spectrometer facility with a trigger designed to enhance the central exclusive meson production reaction over the diffractive reactions. This is done by triggering on a forward and backward fast particle in the c.m.s. with !x^F!~$>$~0.7 and vetoing accompanying forward and backward charged particles. The momentum of the fast particle with x^F~$>$~0.7 will be measured...

  20. Evaluasi Penerapan PP No 71/2010 Tentang Standar Akuntansi Pemrintahan Berbasis Akrual: Studi Kasus di Pemda Nganjuk

    Directory of Open Access Journals (Sweden)

    Dahlia Firdaus

    2016-03-01

    Full Text Available The purpose of this research was to determine the suitability of the accrual basis implementation on Governmental Accounting Standards in Peraturan Pemerintah (PP No. 71/2010 at Nganjuk Regency’s Financial Statements year 2013. This research related with Dinas Pendapatan, Pengelolaan Keuangan dan Aset Daerah (Department of Revenue, Finance and Asset Management. Research proves that Nganjuk Regency’s Financial Statements not yet fully implementing the PP 71/2010. Nganjuk Regency’s financial statements still apply Enclosure II of PP 71/2010 that is cash toward accrual basis. This is due to the application of PP 71/2010 accrual basis (Enclosure I of PP 71/010 are required to be implemented in fiscal year 2015.

  1. Contribution of the two-pion exchange potentials to the P-odd pp-scattering asymmetry at low energies

    International Nuclear Information System (INIS)

    Musakhanov, M.M.; Podgornov, Yu.Yu.

    1985-01-01

    The P-odd asymmetry Asub(pp) of the pp-scattering is calculated within the potential approach for 15 and 45 MeV taking account of the isovector 2π-exchange in additionto the rho 0 ω-exchanges. The corresponding 2 π-potentials areobtained with the account of Δ-isobar configurations. The main contribution of the 2π-exchange to the Asub(pp) is shown to lie in the range of larger internucleon distances than that of the rho 0 , ω-exchange the former must be taken into account while calculating the Asub(pp). The obtained 2π-exchange contribution to the Asub(pp) is comparable with that of the rho 0 , ω-exchange

  2. Differential cross sections of Λ- and bar Λ-hyperon production in bar pp and pp interactions at momenta 12, 32, and 100 GeV/c in the quark-gluon string model

    International Nuclear Information System (INIS)

    Kaidalov, A.B.; Klochkov, M.A.; Sarychev, L.I.; Smirnova, L.N.

    1989-01-01

    The inclusive differential cross sections of Λ- and bar Λ-hyperon production in bar pp and pp interactions at momenta 12, 32, and 100 GeV/c are calculated in the quark-gluon string model and compared with experiment. The model satisfactorily reproduces the experimental data

  3. Control of mitochondrial respiration

    NARCIS (Netherlands)

    Tager, J. M.; Wanders, R. J.; Groen, A. K.; Kunz, W.; Bohnensack, R.; Küster, U.; Letko, G.; Böhme, G.; Duszynski, J.; Wojtczak, L.

    1983-01-01

    The control theory of Kacser and Burns [in: Rate Control of Biological Processes (Davies, D.D. ed) pp. 65-104, Cambridge University Press, London, 1973] and Heinrich and Rapoport [Eur. J. Biochem. (1974) 42, 97-105] has been used to quantify the amount of control exerted by different steps on

  4. Multi-walled carbon nanotube filled polypropylene nanocomposites based on masterbatch route: Improvement of dispersion and mechanical properties through PP-g-MA addition

    Directory of Open Access Journals (Sweden)

    2008-10-01

    Full Text Available Multi-wall carbon nanotubes (MWNTs filled polypropylene (PP nanocomposites were prepared through diluting a PP/MWNT masterbatch in a PP matrix by melt compounding with a twin screw extruder. Polypropylene grafted maleic anhydride (PP-g-MA was used to promote the carbon nanotubes dispersion. The effect of PP-g-MA addition on the rheological, mechanical and morphological properties of the nanocomposites was assessed for different MWNTs loadings. Scanning electron microscopy (SEM has shown that nanotubes are distributed reasonably uniformly. A better dispersion and good adhesion between the nanotubes and the PP matrix is caused by wrapping of PP-g-MA on MWNTs. When PP-g-MA is added, dynamic moduli and viscosity further increases compared to PP/MWNT nanocomposites. The rheological percolation threshold drops significantly. Tensile and flexural moduli and Charpy impact resistance of the nanocomposites also increases by the addition of PP-g-MA. The present study confirms that PP-g-MA is efficient to promote the dispersion of MWNTs in PP matrix and serves as an adhesive to increase their interfacial strength, hence greatly improving the rheological percolation threshold and mechanical properties of PP/MWNT nanocomposites.

  5. Reaction mechanisms in 12C(γ,pp) near 200 MeV

    Science.gov (United States)

    Hackett, E. D.; McDonald, W. J.; Opper, A. K.; Quraan, M. A.; Rodning, N. L.; Rozon, F. M.; Feldman, G.; Kolb, N. R.; Pywell, R. E.; Skopik, D. M.; Tiller, D. E.; Vogt, J. M.; Korkmaz, E.; O'rielly, G. V.

    1996-03-01

    Inclusive 12C(γ,pp) cross sections have been measured with tagged photons in the range Eγ=187-227 MeV using the Saskatchewan-Alberta Large Acceptance Detector (SALAD). The large angular acceptance allowed the measurement of noncoplanar pp emission. The cross sections were compared to a Monte Carlo intranuclear cascade calculation. Agreement was reasonable for the shapes of the cross sections but the calculated total cross section was 3.9 times larger than the data.

  6. Birefringence induced by pp-wave modes in an electromagnetically active dynamic aether

    International Nuclear Information System (INIS)

    Alpin, Timur Yu.; Balakin, Alexander B.

    2017-01-01

    In the framework of the Einstein-Maxwell-aether theory we study the birefringence effect, which can occur in the pp-wave symmetric dynamic aether. The dynamic aether is considered to be a latently birefringent quasi-medium, which displays this hidden property if and only if the aether motion is non-uniform, i.e., when the aether flow is characterized by the non-vanishing expansion, shear, vorticity or acceleration. In accordance with the dynamo-optical scheme of description of the interaction between electromagnetic waves and the dynamic aether, we shall model the susceptibility tensors by the terms linear in the covariant derivative of the aether velocity four-vector. When the pp-wave modes appear in the dynamic aether, we deal with a gravitationally induced degeneracy removal with respect to hidden susceptibility parameters. As a consequence, the phase velocities of electromagnetic waves possessing orthogonal polarizations do not coincide, thus displaying the birefringence effect. Two electromagnetic field configurations are studied in detail: longitudinal and transversal with respect to the aether pp-wave front. For both cases the solutions are found, which reveal anomalies in the electromagnetic response on the action of the pp-wave aether mode. (orig.)

  7. Birefringence induced by pp-wave modes in an electromagnetically active dynamic aether

    Energy Technology Data Exchange (ETDEWEB)

    Alpin, Timur Yu.; Balakin, Alexander B. [Kazan Federal University, Department of General Relativity and Gravitation, Institute of Physics, Kazan (Russian Federation)

    2017-10-15

    In the framework of the Einstein-Maxwell-aether theory we study the birefringence effect, which can occur in the pp-wave symmetric dynamic aether. The dynamic aether is considered to be a latently birefringent quasi-medium, which displays this hidden property if and only if the aether motion is non-uniform, i.e., when the aether flow is characterized by the non-vanishing expansion, shear, vorticity or acceleration. In accordance with the dynamo-optical scheme of description of the interaction between electromagnetic waves and the dynamic aether, we shall model the susceptibility tensors by the terms linear in the covariant derivative of the aether velocity four-vector. When the pp-wave modes appear in the dynamic aether, we deal with a gravitationally induced degeneracy removal with respect to hidden susceptibility parameters. As a consequence, the phase velocities of electromagnetic waves possessing orthogonal polarizations do not coincide, thus displaying the birefringence effect. Two electromagnetic field configurations are studied in detail: longitudinal and transversal with respect to the aether pp-wave front. For both cases the solutions are found, which reveal anomalies in the electromagnetic response on the action of the pp-wave aether mode. (orig.)

  8. Replication-defective lymphocytic choriomeningitis virus vectors expressing guinea pig cytomegalovirus gB and pp65 homologs are protective against congenital guinea pig cytomegalovirus infection.

    Science.gov (United States)

    Cardin, Rhonda D; Bravo, Fernando J; Pullum, Derek A; Orlinger, Klaus; Watson, Elizabeth M; Aspoeck, Andreas; Fuhrmann, Gerhard; Guirakhoo, Farshad; Monath, Thomas; Bernstein, David I

    2016-04-12

    Congenital cytomegalovirus infection can be life-threatening and often results in significant developmental deficits and/or hearing loss. Thus, there is a critical need for an effective anti-CMV vaccine. To determine the efficacy of replication-defective lymphocytic choriomeningitis virus (rLCMV) vectors expressing the guinea pig CMV (GPCMV) antigens, gB and pp65, in the guinea pig model of congenital CMV infection. Female Hartley strain guinea pigs were divided into three groups: Buffer control group (n = 9), rLCMV-gB group (n = 11), and rLCMV-pp65 (n = 11). The vaccines were administered three times IM at 1.54 × 10(6)FFU per dose at 21-day intervals. At two weeks after vaccination, the female guinea pigs underwent breeding. Pregnant guinea pigs were challenged SQ at ∼ 45-55 days of gestation with 1 × 10(5)PFU of GPCMV. Viremia in the dams, pup survival, weights of pups at delivery, and viral load in both dam and pup tissues were determined. Pup survival was significantly increased in the LCMV-gB vaccine group. There was 23% pup mortality in the gB vaccine group (p = 0.044) and 26% pup mortality in the pp65 vaccine group (p = 0.054) compared to 49% control pup mortality. The gB vaccine induced high levels of gB binding and detectable neutralizing antibodies, reduced dam viremia, and significantly reduced viral load in dam tissues compared to control dams (p < 0.03). Reduced viral load and transmission in pups born to gB-vaccinated dams was observed compared to pups from pp65-vaccinated or control dams. The rLCMV-gB vaccine significantly improved pup survival and also increased pup weights and gestation time. The gB vaccine was also more effective at decreasing viral load in dams and pups and limiting congenital transmission. Thus, rLCMV vectors that express CMV antigens may be an effective vaccine strategy for congenital CMV infection. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. What can we learn from high-energy, soft (pp) interactions

    International Nuclear Information System (INIS)

    Basile, M.; Bonvicini, G.; Cara Romeo, G.; Cifarelli, L.; Contin, A.; Curatolo, M.; D'Ali, G.; Esposito, B.

    1983-01-01

    This chapter reports on a series of similarities between multiparticle hadronic systems produced in (pp) interactions and in (e + e - ) annihilation. Explains that in order to establish these similarities, the basic principle is to evaluate, for each (pp) interaction, the correct energy available for particle production. Examines the comparison of the multiparticle hadronic systems produced in (pp) interactions and (e + e - ) annihilation in terms of: 1) the inclusive, single-particle, fractional momentum distribution of the produced particles; 2) the inclusive, single particle, transverse momentum distribution of the particles produced; 3) the average charged particle multiplicity; 4) the ratio of ''charged'' to ''total'' energy of the multiparticle hadronic systems produced; and 5) the planarity of the multiparticle hadronic systems produced. Concludes that hadronic production in (e + e - ) annihilation takes place in such a way that no hadron has a privileged energy sharing. Points out that in order to understand the way in which the multiparticle hadronic systems are produced in strong, electromagnetic, and weak interactions, all p /SUB T/ physics needs to be investigated. Presents discussion featuring Zichichi, Herten, Karliner and others

  10. The PP2AB56 phosphatase promotes the association of Cdc20 with APC/C in mitosis.

    Science.gov (United States)

    Lee, Sun Joo; Rodriguez-Bravo, Veronica; Kim, Hyunjung; Datta, Sutirtha; Foley, Emily A

    2017-05-15

    PP2A comprising B56 regulatory subunit isoforms (PP2A B56 ) is a serine/threonine phosphatase essential for mitosis. At the kinetochore, PP2A B56 both stabilizes microtubule binding and promotes silencing of the spindle assembly checkpoint (SAC) through its association with the SAC protein BubR1. Cells depleted of the B56 regulatory subunits of PP2A are delayed in activation of Cdc20-containing APC/C (APC/C Cdc20 ), which is an essential step for mitotic exit. It has been hypothesized that this delay arises from increased production of the mitotic checkpoint complex (MCC), an APC/C Cdc20 inhibitor formed at unattached kinetochores through SAC signaling. In contrast to this prediction, we show that depletion of B56 subunits does not increase the amount or stability of the MCC. Rather, delays in APC/C Cdc20 activation in B56-depleted cells correlate with impaired Cdc20 binding to APC/C. Stimulation of APC/C Cdc20 assembly does not require binding between PP2A B56 and BubR1, and thus this contribution of PP2A B56 towards mitotic exit is distinct from its functions at kinetochores. PP2A B56 associates with APC/C constitutively in a BubR1-independent manner. A mitotic phosphorylation site on Cdc20, known to be a substrate of PP2A B56 , modulates APC/C Cdc20 assembly. These results elucidate the contributions of PP2A B56 towards completion of mitosis. © 2017. Published by The Company of Biologists Ltd.

  11. Cross-cultural adaptation of the delphi definitions of low back pain prevalence (German DOLBaPP).

    Science.gov (United States)

    Leonhardt, Marja; Liebers, Falk; Dionne, Clermont E; Latza, Ute

    2014-11-25

    Assessed dimensions of low back pain (LBP) vary in prevalence studies. This may explain the heterogeneity in frequency estimates. To standardize definitions of LBP, an English consensus with 28 experts from 12 countries developed the "Delphi Definitions of Low Back Pain Prevalence" (DOLBaPP). The optimal definition and the shorter minimal definition with the related questionnaires for online, paper, and face-to-face use and telephone surveys are suitable for population-based studies. The definitions have to be adapted to different languages and cultures to provide comparable frequency estimates. The objective was to culturally adapt and pre-test the English definitions and corresponding Delphi DOLBaPP questionnaire forms into German. The German DOLBaPP adaptation was conducted using the systematic approach suggested by Beaton et al. A pre-test of the Delphi DOLBaPP optimal paper questionnaire including an additional evaluation form was conducted in a sample of 121 employees (mainly office workers). In order to evaluate the comprehensibility, usability, applicability, and completeness of the adapted questionnaire, response to the questionnaire and 6 closed evaluation questions were analyzed descriptively. Qualitative methods were used for the 3 open questions of the evaluation form. The cultural adaptation of the DOLBaPP for a German-speaking audience required little linguistic adaptation. Conceptual equivalence was difficult for the expression "low back pain". The expert committee considered the face validity of the pre-final version of the related Delphi DOLBaPP questionnaires as good. In the pre-test, most participants (95%) needed less than 5 minutes to fill in the optimal Delphi DOLBaPP questionnaire. They were generally positive regarding length, wording, diagram, and composition. All subjects with LBP (n=61 out of 121 - 50.4%) answered the questions on functional limitation, sciatic pain, frequency and duration of symptoms as well as pain severity. The

  12. Pharmacological Activation of Protein Phosphatase 2 A (PP2A): A Novel Strategy to Fight Against Human Malignancies?

    Science.gov (United States)

    Carratù, Maria Rosaria; Signorile, Anna; De Rasmo, Domenico; Reale, Antonia; Vacca, Angelo

    2016-01-01

    The serine-threonine protein phosphatase 2A (PP2A) regulates multiple cell signaling cascades and its inactivation by viral oncoproteins, mutation of specific structural subunits or upregulation of the cellular endogenous inhibitors may contribute to malignant transformation by regulating specific phosphorylation events. Pharmacological modulation of PP2A activity is becoming an attractive strategy for cancer treatment. Some compounds targeting PP2A are able to induce PP2A reactivation and subsequent cell death in several types of cancer. We undertook a search of bibliographic databases for peer-reviewed articles focusing on the main item of the review. We selected articles published in indexed journals. The quality of retrieved papers was appraised using the standard bibliometric indicators. One hundred and fourteen papers were included in the review. Twenty-seven papers gave an overview of structure and physiological role of PP2A. Twenty-five papers outlined the role of PP2A in tumor suppression. Forty papers analyzed the mechanism involved in PP2A reactivation by synthetic compounds, and twenty-two papers outlined the capability of natural compounds of restoring PP2A activity and how this could be beneficial. Findings analyzed in this review underline the central role of PP2A as a regulator of cell growth and survival, hence its function as tumor suppressor. The discovery that some compounds, either synthetic or natural, are capable of reactivating PP2A opens up new perspectives for future strategies to fully exploit therapeutic potential in human cancer. Thus, this review could also be of particular interest to pharmaceutical or biotechnology companies for drug design and targeted delivery.

  13. AtPP2CG1, a protein phosphatase 2C, positively regulates salt tolerance of Arabidopsis in abscisic acid-dependent manner

    International Nuclear Information System (INIS)

    Liu, Xin; Zhu, Yanming; Zhai, Hong; Cai, Hua; Ji, Wei; Luo, Xiao; Li, Jing; Bai, Xi

    2012-01-01

    Highlights: ► AtPP2CG1 positively regulates salt tolerance in ABA-dependent manner. ► AtPP2CG1 up-regulates the expression of marker genes in different pathways. ► AtPP2CG1 expresses in the vascular system and trichomes of Arabidopsis. -- Abstract: AtPP2CG1 (Arabidopsis thaliana protein phosphatase 2C G Group 1) was predicted as an abiotic stress candidate gene by bioinformatic analysis in our previous study. The gene encodes a putative protein phosphatase 2C that belongs to Group G of PP2C. There is no report of Group G genes involved in abiotic stress so far. Real-time RT-PCR analysis showed that AtPP2CG1 expression was induced by salt, drought, and abscisic acid (ABA) treatment. The expression levels of AtPP2CG1 in the ABA synthesis-deficient mutant abi2–3 were much lower than that in WT plants under salt stress suggesting that the expression of AtPP2CG1 acts in an ABA-dependent manner. Over-expression of AtPP2CG1 led to enhanced salt tolerance, whereas its loss of function caused decreased salt tolerance. These results indicate that AtPP2CG1 positively regulates salt stress in an ABA-dependent manner. Under salt treatment, AtPP2CG1 up-regulated the expression levels of stress-responsive genes, including RD29A, RD29B, DREB2A and KIN1. GUS activity was detected in roots, leaves, stems, flower, and trichomes of AtPP2CG1 promoter–GUS transgenic plants. AtPP2CG1 protein was localized in nucleus and cytoplasm via AtPP2CG1:eGFP and YFP:AtPP2CG1 fusion approaches.

  14. AtPP2CG1, a protein phosphatase 2C, positively regulates salt tolerance of Arabidopsis in abscisic acid-dependent manner

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Xin, E-mail: fangfei6073@126.com [Plant Bioengineering Laboratory, Northeast Agricultural University, Harbin 150030 (China); Zhu, Yanming, E-mail: ymzhu2001@neau.edu.cn [Plant Bioengineering Laboratory, Northeast Agricultural University, Harbin 150030 (China); Zhai, Hong, E-mail: Zhai.h@neigaehrb.ac.cn [Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Harbin 150040 (China); Cai, Hua, E-mail: small-big@sohu.com [Plant Bioengineering Laboratory, Northeast Agricultural University, Harbin 150030 (China); Ji, Wei, E-mail: iwei_j@hotmail.com [Plant Bioengineering Laboratory, Northeast Agricultural University, Harbin 150030 (China); Luo, Xiao, E-mail: luoxiao2010@yahoo.cn [Plant Bioengineering Laboratory, Northeast Agricultural University, Harbin 150030 (China); Li, Jing, E-mail: lijing@neau.edu.cn [Plant Secondary Metabolism Laboratory, Northeast Agricultural University, Harbin 150030 (China); Bai, Xi, E-mail: baixi@neau.edu.cn [Plant Bioengineering Laboratory, Northeast Agricultural University, Harbin 150030 (China)

    2012-06-15

    Highlights: Black-Right-Pointing-Pointer AtPP2CG1 positively regulates salt tolerance in ABA-dependent manner. Black-Right-Pointing-Pointer AtPP2CG1 up-regulates the expression of marker genes in different pathways. Black-Right-Pointing-Pointer AtPP2CG1 expresses in the vascular system and trichomes of Arabidopsis. -- Abstract: AtPP2CG1 (Arabidopsis thaliana protein phosphatase 2C G Group 1) was predicted as an abiotic stress candidate gene by bioinformatic analysis in our previous study. The gene encodes a putative protein phosphatase 2C that belongs to Group G of PP2C. There is no report of Group G genes involved in abiotic stress so far. Real-time RT-PCR analysis showed that AtPP2CG1 expression was induced by salt, drought, and abscisic acid (ABA) treatment. The expression levels of AtPP2CG1 in the ABA synthesis-deficient mutant abi2-3 were much lower than that in WT plants under salt stress suggesting that the expression of AtPP2CG1 acts in an ABA-dependent manner. Over-expression of AtPP2CG1 led to enhanced salt tolerance, whereas its loss of function caused decreased salt tolerance. These results indicate that AtPP2CG1 positively regulates salt stress in an ABA-dependent manner. Under salt treatment, AtPP2CG1 up-regulated the expression levels of stress-responsive genes, including RD29A, RD29B, DREB2A and KIN1. GUS activity was detected in roots, leaves, stems, flower, and trichomes of AtPP2CG1 promoter-GUS transgenic plants. AtPP2CG1 protein was localized in nucleus and cytoplasm via AtPP2CG1:eGFP and YFP:AtPP2CG1 fusion approaches.

  15. Phenomenology at the CERN pp-bar collider

    International Nuclear Information System (INIS)

    Phillips, R.J.N.

    1986-05-01

    The paper concerns some comparisons of theory with high-psub(T) data from the CERN pp-bar collider, beginning with some background about the machine and detectors. Later sections describe weak boson searches, high psub(T) jets, heavy quark phenomena and possible E 6 exotica from superstrings. (author)

  16. Systems and Control Engineering

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 4; Issue 1. Systems and Control Engineering - Notions of Control. A Rama Kalyan J R Vengateswaran. General Article Volume 4 Issue 1 January 1999 pp 45-52. Fulltext. Click here to view fulltext PDF. Permanent link:

  17. Quantum square-well with logarithmic central spike

    Czech Academy of Sciences Publication Activity Database

    Znojil, Miloslav; Semorádová, Iveta

    2018-01-01

    Roč. 33, č. 2 (2018), č. článku 1850009. ISSN 0217-7323 R&D Projects: GA ČR GA16-22945S Institutional support: RVO:61389005 Keywords : state-dependence of interactions * effective Hamiltonians * logarithmic nonlinearities * linearized quantum toy model Subject RIV: BE - Theoretical Physics OBOR OECD: Atomic, molecular and chemical physics ( physics of atoms and molecules including collision, interaction with radiation, magnetic resonances, Mössbauer effect) Impact factor: 1.165, year: 2016

  18. On eigenvalues of a PT-symmetric operator in a thin layer

    Czech Academy of Sciences Publication Activity Database

    Borisov, D. I.; Znojil, Miloslav

    2017-01-01

    Roč. 208, č. 2 (2017), s. 173-199 ISSN 1064-5616 R&D Projects: GA ČR GA16-22945S Institutional support: RVO:61389005 Keywords : thin domain * pT-symmetric operator * edge of a gap * asymptotics * periodic operator Subject RIV: BE - Theoretical Physics OBOR OECD: Atomic, molecular and chemical physics (physics of atoms and molecules including collision, interaction with radiation, magnetic resonances, Mössbauer effect) Impact factor: 0.721, year: 2016

  19. The role of picture of process (pp) on senior high school students’ collision concept learning activities and multirepresentation ability

    Science.gov (United States)

    Sutarto; Indrawati; Wicaksono, I.

    2018-04-01

    The objectives of the study are to describe the effect of PP collision concepts to high school students’ learning activities and multirepresentation abilities. This study was a quasi experimental with non- equivalent post-test only control group design. The population of this study were students who will learn the concept of collision in three state Senior High Schools in Indonesia, with a sample of each school 70 students, 35 students as an experimental group and 35 students as a control group. Technique of data collection were observation and test. The data were analized by descriptive and inferensial statistic. Student learning activities were: group discussions, describing vectors of collision events, and formulating problem-related issues of impact. Multirepresentation capabilities were student ability on image representation, verbal, mathematics, and graph. The results showed that the learning activities in the three aspects for the three high school average categorized good. The impact of using PP on students’ ability on image and graph representation were a significant impact, but for verbal and mathematical skills there are differences but not significant.

  20. Penrose limits, pp waves, and deformed M2-branes

    International Nuclear Information System (INIS)

    Cvetic, M.; Lue, H.; Pope, C.N.

    2004-01-01

    Motivated by the recent discussions of the Penrose limit of AdS 5 xS 5 , we examine a more general class of supersymmetric pp-wave solutions of the type IIB theory, with a larger number of nonvanishing structures in the self-dual 5-form. One of the pp-wave solutions can be obtained as a Penrose limit of a D3-D3 intersection. In addition to 16 standard supersymmetries these backgrounds always allow for supernumerary supersymmetries. The latter are in one-to-one correspondence with the linearly realized world-sheet supersymmetries of the corresponding exactly solvable type IIB string action. The pp-waves provide new examples where supersymmetries will survive in a T-duality transformation on the x + coordinate. The T-dual solutions can be lifted to give supersymmetric deformed M2-branes in D=11. The deformed M2-brane is dual to a three-dimensional field theory whose renormalization group flow runs from the conformal fixed point in the infrared regime to a nonconformal theory as the energy increases. At a certain intermediate energy scale there is a phase transition associated with a naked singularity of the M2-brane. In the ultraviolet limit the theory is related by T duality to an exactly solvable massive type IIB string theory

  1. First real–time detection of solar pp neutrinos by Borexino

    Directory of Open Access Journals (Sweden)

    Pallavicini M.

    2016-01-01

    Full Text Available Solar neutrinos have been pivotal to the discovery of neutrino flavour oscillations and are a unique tool to probe the reactions that keep the Sun shine. Although most of solar neutrino components have been directly measured, the neutrinos emitted by the keystone pp reaction, in which two protons fuse to make a deuteron, have so far eluded direct detection. The Borexino experiment, an ultra–pure liquid scintillator detector running at the Laboratori Nazionali del Gran Sasso in Italy, has now filled the gap, providing the first direct real time measurement of pp neutrinos and of the solar neutrino luminosity.

  2. Overexpression of HDAC1 induces cellular senescence by Sp1/PP2A/pRb pathway

    International Nuclear Information System (INIS)

    Chuang, Jian-Ying; Hung, Jan-Jong

    2011-01-01

    Highlights: → Overexpression of HDAC1 induces Sp1 deacetylation and raises Sp1/p300 complex formation to bind to PP2Ac promoter. → Overexpression of HDAC1 strongly inhibits the phosphorylation of pRb through up-regulation of PP2A. → Overexpressed HDAC1 restrains cell proliferaction and induces cell senescence though a novel Sp1/PP2A/pRb pathway. -- Abstract: Senescence is associated with decreased activities of DNA replication, protein synthesis, and cellular division, which can result in deterioration of cellular functions. Herein, we report that the growth and division of tumor cells were significantly repressed by overexpression of histone deacetylase (HDAC) 1 with the Tet-off induced system or transient transfection. In addition, HDAC1 overexpression led to senescence through both an accumulation of hypophosphorylated active retinoblastoma protein (pRb) and an increase in the protein level of protein phosphatase 2A catalytic subunit (PP2Ac). HDAC1 overexpression also increased the level of Sp1 deacetylation and elevated the interaction between Sp1 and p300, and subsequently that Sp1/p300 complex bound to the promoter of PP2Ac, thus leading to induction of PP2Ac expression. Similar results were obtained in the HDAC1-Tet-off stable clone. Taken together, these results indicate that HDAC1 overexpression restrained cell proliferation and induced premature senescence in cervical cancer cells through a novel Sp1/PP2A/pRb pathway.

  3. Overexpression of HDAC1 induces cellular senescence by Sp1/PP2A/pRb pathway

    Energy Technology Data Exchange (ETDEWEB)

    Chuang, Jian-Ying [Department of Pharmacology, National Cheng-Kung University, Tainan 701, Taiwan (China); Hung, Jan-Jong, E-mail: petehung@mail.ncku.edu.tw [Department of Pharmacology, National Cheng-Kung University, Tainan 701, Taiwan (China); Institute of Bioinformatics and Biosignal Transduction, National Cheng-Kung University, Tainan 701, Taiwan (China)

    2011-04-15

    Highlights: {yields} Overexpression of HDAC1 induces Sp1 deacetylation and raises Sp1/p300 complex formation to bind to PP2Ac promoter. {yields} Overexpression of HDAC1 strongly inhibits the phosphorylation of pRb through up-regulation of PP2A. {yields} Overexpressed HDAC1 restrains cell proliferaction and induces cell senescence though a novel Sp1/PP2A/pRb pathway. -- Abstract: Senescence is associated with decreased activities of DNA replication, protein synthesis, and cellular division, which can result in deterioration of cellular functions. Herein, we report that the growth and division of tumor cells were significantly repressed by overexpression of histone deacetylase (HDAC) 1 with the Tet-off induced system or transient transfection. In addition, HDAC1 overexpression led to senescence through both an accumulation of hypophosphorylated active retinoblastoma protein (pRb) and an increase in the protein level of protein phosphatase 2A catalytic subunit (PP2Ac). HDAC1 overexpression also increased the level of Sp1 deacetylation and elevated the interaction between Sp1 and p300, and subsequently that Sp1/p300 complex bound to the promoter of PP2Ac, thus leading to induction of PP2Ac expression. Similar results were obtained in the HDAC1-Tet-off stable clone. Taken together, these results indicate that HDAC1 overexpression restrained cell proliferation and induced premature senescence in cervical cancer cells through a novel Sp1/PP2A/pRb pathway.

  4. Algorithms for Robust Identification and Control of Large Space Structures. Phase 1.

    Science.gov (United States)

    1988-05-14

    Variate Analysis," Proc. Amer. Control Conf., San Francisco, * pp. 445-451. LECTIQUE, J., Rault, A., Tessier, M., and Testud , J.L. (1978), "Multivariable...Rault, J.L. Testud , and J. Papon (1978), "Model Predictive Heuris- tic Control: Applications to Industrial Processes," Automatica, Vol. 14, pp. 413...Control ’. Conference, Minneapolis, MN, June. TESTUD , J.L. (1979), "Commande Numerique Multivariable du Ballon de Recupera- tion de Vapeur," Adersa/Gerbios

  5. Expanding the functional significance of automated control systems for the production process at hydroelectric plants

    International Nuclear Information System (INIS)

    Vasil'ev, Yu.S.; Kononova, M.Yu.

    1993-01-01

    Automated control systems for the production process (ACS PP) have been successfully implemented in a number of hydroelectric plants in the Russian Federation. The circle of problems that can be solved using ACS PP can be conditionally divided into two classes: on-line/technological control, and production-technological control. This article describes successes and future directions for the solution of these two classes of problems. From the discussion, it is concluded (1) that the data base for existing ACS PP at hydroelectric plants can be successfully employed as points for monitoring the conservation of an environment of local significance; (2) that is is expedient to discuss the problem with organizations, including local control groups interested in the development of territorial-basin systems for ecological monitoring; and (3) that the initiative in creating local territorial-basin support points for monitoring should emanate from guidelines for hydroelectric plants with ACS PP. 3 refs., 2 figs

  6. Storage Stability Improvement of Copolymer Grafted Polypropylene-AcrylicAcid (PP-AA), by means of Various After Treatment Processes

    International Nuclear Information System (INIS)

    Gitopadmojo, Isminingsih

    2000-01-01

    Polypropylene yams that have been subjected to irradiation induced graftco-polymerization with acrylic acid, have gained its moisture regain and dyeability, that fulfilled the requirement as textile material for garment.However, the copolymer grafted PP-AA has suffered from degradation in thestorage, which was indicated in the previous study that the strengthretention has dropped tremendously by photo-oxidation or photo-degradation.After treatments of PP-AA yams with chemical compound that was able toprevent further photo-oxidation, will be expected to improve the stability ofPP-AA in storage. In this research activity, the polypropylene (PP) yams weresubjected to irradiation induced graft co-polymerization by means ofγ-Ray Co-60 as irradiation source with acrylic acid (AA) as monomer.Various after treatments were subjected to the grafted PP-AA yams such asalkalisation process; dyeing (anionic dyes, cationic dyes and nonionic dyes);as well as processing with optical brightening agent and UV stabilizer,separately. The PP-AA yams (before and after treatment) were subjected tostorage from 1 month up to 42 months, and then being tested for theirmoisture regain, strength retention and elongation at breaks. The samplesbeing stored for 12 months were subjected to radical analysis. It isconcluded from the experiment that after treatment of grafted PP-AA by meansof those various processes were able to improve the stability of copolymergrafted PP-AA in storage. The presence of peroxide radical in the ESR(electron spin resonance) spectrum on PP-AA yams before treatment and theones after treated with alkaline and being stored for 12 months haveindicated the presence of photo oxidation or photo degradation, while thepresence of poly enyl radical in the ESR spectrum of after treated PP-AA withdyes having azo and azine compound as chromophore, as well as with UVstabilizer with carbonyl as chromophore and being stored for 12 months haveproved that its presence have protected such

  7. Plasma enhanced modification of TMP fiber and its effect on tensile strength of wood fiber/PP composite

    Science.gov (United States)

    Sangyeob Lee; Todd F. Shupe; Chung Y. Hse

    2009-01-01

    Plasma-assisted surface treatment on thermomechanical pulp (TMP) fiber and polypropylene (PP) film was investigated to obtain interfacial adhesion at the wood fiber and PP interface. A metal plate between electrodes prevented thermal damage to the TMP fiber handsheets and PP film. Oxygen-plasma treatment provided better surface activation on the TMP fiber and...

  8. anti pp elastic scattering at 30 GeV/c incident momentum in the momentum transfer range 0.52

    International Nuclear Information System (INIS)

    Asa'd, Z.; Coupland, M.; Davis, D.G.; Duff, B.G.; Fearnley, T.; Heymann, F.F.; Imrie, D.C.; Lush, G.J.; Phillips, M.; Baglin, A.; Guillard, J.P.; Poulet, M.; Brom, J.M.; Myrheim, J.; Kenyon Gjerpe, I.; Buran, T.; Buzzo, A.; Ferroni, S.; Gracco, V.; Khan, E.; Kirsebom, K.; Macri, M.; Rossi, L.; Santroni, A.; Skjevling, G.; Sorensen, S.O.

    1983-01-01

    The anti pp elastic differential cross section at 30 GeV/c incident momentum has been measured in a two-arm spectrometer experiment (WA7) at the CERN SPS. The vertical stroketvertical stroke-range covered extends from 0.5 to 5.8 (GeV/c) 2 . A pronounced dip-bump structure is observed, with a sharp minimum around vertical stroketvertical strokeapprox.=1.7 (GeV/c) 2 . The results are compared with existing anti pp data at lower energies and with our earlier anti pp data at 50 GeV/c. A number of model predictions are discussed. We also compare the anti pp 30 GeV/c differential cross section with that of pp at the same momentum. Finally, the energy dependence of the anti pp fixed-vertical stroketvertical stroke differential cross section in the incident momentum range 3.6 to 50 GeV/c is presented. (orig.)

  9. QCD with jets and heavy flavour in pp and PbPb collisions in ATLAS

    International Nuclear Information System (INIS)

    Keyes, Robert

    2016-01-01

    ATLAS has studied different aspects of QCD in pp and PbPb collisions. A summary of interesting recent results at centre-of-mass energies of 7 TeV, 8 TeV and 13 TeV (pp), and 2.76 TeV (PbPb) per nucleon pair is presented. Using pp collisions, measurements of Z, W, photon, quarkonia and open charm production differential cross sections in a variety of variables are presented. Jet and heavy flavour muon measurements in PbPb collisions, aimed to test the properties of the Quark Gluon Plasma, with the view of better understanding of jet quenching, are also presented.

  10. QCD with Jets and Heavy Flavour in pp and PbPb Collisions in ATLAS

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00377077; The ATLAS collaboration

    2016-01-01

    ATLAS has studied different aspects of QCD in pp and PbPb collisions. A summary of interesting recent results at centre-of-mass energies of 7 TeV, 8 TeV and 13 TeV (pp), and 2.76 TeV (PbPb) per nucleon pair is presented. Measurements using pp collisions of Z, W, photon, quarkonia and open charm production differential cross sections in a variety of variables are presented. Jet and heavy flavour muon measurements in PbPb collisions, aimed to test the properties of the Quark Gluon Plasma with the view of better understanding of jet quenching, are also presented.

  11. Multiple phosphorylation sites at the C-terminus regulate nuclear import of HCMV DNA polymerase processivity factor ppUL44

    International Nuclear Information System (INIS)

    Alvisi, Gualtiero; Marin, Oriano; Pari, Gregory; Mancini, Manuela; Avanzi, Simone; Loregian, Arianna; Jans, David A.; Ripalti, Alessandro

    2011-01-01

    The processivity factor of human cytomegalovirus DNA polymerase, phosphoprotein ppUL44, is essential for viral replication. During viral infection ppUL44 is phosphorylated by the viral kinase pUL97, but neither the target residues on ppUL44 nor the effect of phosphorylation on ppUL44's activity are known. We report here that ppUL44 is phosphorylated when transiently expressed in mammalian cells and coimmunoprecipitates with cellular kinases. Of three potential phosphorylation sites (S413, S415, S418) located upstream of ppUL44's nuclear localization signal (NLS) and one (T427) within the NLS itself, protein kinase CK2 (CK2) specifically phosphorylates S413, to trigger a cascade of phosphorylation of S418 and S415 by CK1 and CK2, respectively. Negative charge at the CK2/CK1 target serine residues facilitates optimal nuclear accumulation of ppUL44, whereas negative charge on T427, a potential cyclin-dependent 1 phosphorylation site, strongly decreases nuclear accumulation. Thus, nuclear transport of ppUL44 is finely tuned during viral infection through complex phosphorylation events.

  12. Search for substructure in anti pp total cross section in the 2200 MeV mass region

    International Nuclear Information System (INIS)

    Peaslee, D.C.; DeMarzo, C.; Guerriero, L.

    1975-01-01

    The anti pp total cross section is measured in an apparatus with a small target and high resolution beam in order to supplement previous work by looking for narrow structure that might be hidden in broad-mass bins. One could set limits on the partial widths of bosons coupling to the anti pp system. The product of an unknown production cross section and a partial width was determined. From the data the existence of resolution-sized structure above the smooth fit with the product of cross section and width greater than 7 MeV mb. It can be shown that a Breit--Wigner resonance of spin J coupled to the anti pp system in this region must have partial width GAMMA/sub anti pp/ less than 1.8/(2J + 1) MeV. Also it is found that the broad enhancement observed in the anti pp total cross section persists without modification in an observation with mass resolution six times that of previous work

  13. Reaction mechanisms in 12C(γ,pp) near 200 MeV

    International Nuclear Information System (INIS)

    Hackett, E.D.; McDonald, W.J.; Opper, A.K.; Quraan, M.A.; Rodning, N.L.; Rozon, F.M.; Feldman, G.; Kolb, N.R.; Pywell, R.E.; Skopik, D.M.; Tiller, D.E.; Vogt, J.M.; Korkmaz, E.; ORielly, G.V.

    1996-01-01

    Inclusive 12 C(γ,pp) cross sections have been measured with tagged photons in the range E γ =187 endash 227 MeV using the Saskatchewan-Alberta Large Acceptance Detector (SALAD). The large angular acceptance allowed the measurement of noncoplanar pp emission. The cross sections were compared to a Monte Carlo intranuclear cascade calculation. Agreement was reasonable for the shapes of the cross sections but the calculated total cross section was 3.9 times larger than the data. copyright 1996 The American Physical Society

  14. Deformation and failure kinetics of iPP polymorphs

    NARCIS (Netherlands)

    Caelers, H.J.M.; Parodi, E.; Cavallo, D.; Peters, G.W.M.; Govaert, L.E.

    2017-01-01

    In this study, the mechanical performance of thedifferent polymorphs of isotactic polypropylene, typically pre-sent in iPP crystallized under industrial processing conditions,is assessed. Different preparation strategies were used toobtain samples consisting of almost solely alpha, beta, or gamma

  15. Controlling lipid oxidation via a biomimetic iron chelating active packaging material.

    Science.gov (United States)

    Tian, Fang; Decker, Eric A; Goddard, Julie M

    2013-12-18

    Previously, a siderophore-mimetic metal chelating active packaging film was developed by grafting poly(hydroxamic acid) (PHA) from the surface of polypropylene (PP) films. The objective of the current work was to demonstrate the potential applicability of this PP-g-PHA film to control iron-promoted lipid oxidation in food emulsions. The iron chelating activity of this film was investigated, and the surface chemistry and color intensity of films were also analyzed after iron chelation. In comparison to the iron chelating activity in the free Fe(3+) solution, the PP-g-PHA film retained approximately 50 and 30% of its activity in nitrilotriacetic acid (NTA)/Fe(3+) and citric acid/Fe(3+) solutions, respectively (pH 5.0), indicating a strong chelating strength for iron. The ability of PP-g-PHA films to control lipid oxidation was demonstrated in a model emulsion system (pH 3.0). PP-g-PHA films performed even better than ethylenediaminetetraacetic acid (EDTA) in preventing the formation of volatile oxidation products. The particle size and ζ potential results of emulsions indicated that PP-g-PHA films had no adverse effects on the stability of the emulsion system. Attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) analysis suggested a non-migratory nature of the PP-g-PHA film surface. These results suggest that such biomimetic, non-migratory metal chelating active packaging films have commercial potential in protecting foods against iron-promoted lipid oxidation.

  16. Highly acidic C-terminal domain of pp32 is required for the interaction with histone chaperone, TAF-Ibeta.

    Science.gov (United States)

    Lee, In-Seon; Oh, Sang-Min; Kim, Sung-Mi; Lee, Dong-Seok; Seo, Sang-Beom

    2006-12-01

    We have previously reported that INHAT (inhibitor of acetyltransferases) complex subunits, TAF (template activating factor)-Ialpha, TAF-Ibeta and pp32 can inhibit histone acetylation and HAT (histone acetyltransferase)-dependent transcription by binding to histones. Evidences are accumulating that INHAT complex subunits have important regulatory roles in various cellular activities such as replication, transcription, and apoptosis etc. However, how these subunits interact each other remains largely unknown. Using immunoprecipitation (IP) and protein-protein interaction assays with TAF-Ibeta and pp32 deletion mutant proteins, we identify INHAT complex subunits, TAF-Ibeta and pp32 interaction requires highly acidic C-terminal domain of pp32. We also show that the interaction between the INHAT complex subunits is stronger in the presence of histones. In this study, we report that the synergistic inhibition of HAT-mediated transcription by TAF-Ibeta and pp32 is dependent on the highly acidic C-terminal domain of pp32.

  17. Slug-Tests in PP- and PVP-holes at Olkiluoto in 2007

    International Nuclear Information System (INIS)

    Keskitalo, K.

    2008-05-01

    As part of the program for the final disposal of the nuclear fuel waste, Posiva Oy investigates the hydrological conditions at the Olkiluoto island. The hydraulic conductivity in the shallow holes OL-PP9, OL-PP36, OL-PP39, OL-PVP3A, OL-PVP3B, OL-PVP4A, OL-PVP4B, OL-PVP6A, OL-PVP6B, OL-PVP7A, OL-PVP8A, OL-PVP8B, OL-PVP9A, OL-PVP9B, OL-PVP10A, OL-PVP10B, OL-PVP11, OL-PVP12, OL-PVP13, OL-PVP14, OL-PVP17, OL-PVP18A, OL-PVP18B, OL-PVP19 and OL-PVP20 was measured in summer 2007. The length of PP-holes varies between 12 and 15 m, and the test sections (1 m) are located in the bedrock. PVP-tubes have an average length between 3 - 9 m up to 17 m, and the test sections (mostly 2 m) are located in the overburden. The measurements were done using the slug-test technique. In the slug-test, the hydraulic head in the borehole is abruptly changed either by pouring water into the borehole or by lowering the pressure sensor. The conductivity is interpreted based on the recovery of the water level. This report presents the field measurements and their interpretation. The interpretation has been done using the Hvorslev's method, and for reference, conductivity has also been calculated according to Thiem's equation. According to the results, hydraulic conductivity in PP-holes ranges from 10-9 m/s to 10-6 m/s and in PVP-tubes from 10-8 m/s to 10-4 m/s. The range is similar as observed in measurements of years 2002, 2004, 2005 and 2006. In general, the results are consistent with the results obtained in earlier measurements. Some exceptions exist in OL-PVP6B, where the conductivity is higher than in the earlier measurements. In OL-PVP14, there seems to be a lowering trend of the conductivity. In OL-PP9, the conductivity in test section 5.3 - 6.3 m in 2007 was about one order of magnitude lower than in 2005 but the results from 2007, 2006, and 2002 correlate well in that section. Also, the results agree with hydraulic conductivity interpreted from the pre-pumping done in connection with

  18. Study of the weathering of high melt strength polypropylene (HMS-PP)

    Energy Technology Data Exchange (ETDEWEB)

    Oliani, Washington L.; Parra, Duclerc F.; Otaguro, Harumi; Lima, Luis F.C.P.; Lugao, Ademar B. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)], E-mail: dfparra@ipen.br

    2007-07-01

    One of the reasons for the good acceptance of the commercial PP is the fact that market requires products with features of 'engineering plastics' with prices in the range of commodities. High melt strength polypropylene (HMSPP) grades are produced by radiation process and have improved rheology for melt blow processes. The melt strength (MS) properties of a polymer increase with molecular weight and with long chain branching due to the increase in the entanglement level. The main scope of this study was to evaluate the stability of HMS-PP prepared by gamma radiation with doses of 12.5, 20 kGy in comparison with virgin PP. Many variables influence the rate of degradation of polymers by photo-oxidation. The irradiance and permeability to oxygen are the most important factors but other factors such as temperature and moisture have also influenced the degradation rates. Polypropylenes are sensitive to oxidation due to the presence of the tertiary carbon atom. Therefore, effective stabilization against oxidation (thermo and photo oxidation) is required. The samples submitted to the natural aging for a period of six months were characterized by: tensile test, thermogravimetry analysis (TGA), optical microscopy, scanning electronic microscopy (SEM) and infrared spectroscopy (FTIR). SEM analysis showed particular aspects of cracks on the surface. The loss of tensile strength is associated to the presence of fractures. The results showed that pronounced oxidation followed by chain scission occur at the initial periods of weathering exposition of the HMS-PP. (author)

  19. Study of the weathering of high melt strength polypropylene (HMS-PP)

    International Nuclear Information System (INIS)

    Oliani, Washington L.; Parra, Duclerc F.; Otaguro, Harumi; Lima, Luis F.C.P.; Lugao, Ademar B.

    2007-01-01

    One of the reasons for the good acceptance of the commercial PP is the fact that market requires products with features of 'engineering plastics' with prices in the range of commodities. High melt strength polypropylene (HMSPP) grades are produced by radiation process and have improved rheology for melt blow processes. The melt strength (MS) properties of a polymer increase with molecular weight and with long chain branching due to the increase in the entanglement level. The main scope of this study was to evaluate the stability of HMS-PP prepared by gamma radiation with doses of 12.5, 20 kGy in comparison with virgin PP. Many variables influence the rate of degradation of polymers by photo-oxidation. The irradiance and permeability to oxygen are the most important factors but other factors such as temperature and moisture have also influenced the degradation rates. Polypropylenes are sensitive to oxidation due to the presence of the tertiary carbon atom. Therefore, effective stabilization against oxidation (thermo and photo oxidation) is required. The samples submitted to the natural aging for a period of six months were characterized by: tensile test, thermogravimetry analysis (TGA), optical microscopy, scanning electronic microscopy (SEM) and infrared spectroscopy (FTIR). SEM analysis showed particular aspects of cracks on the surface. The loss of tensile strength is associated to the presence of fractures. The results showed that pronounced oxidation followed by chain scission occur at the initial periods of weathering exposition of the HMS-PP. (author)

  20. 76 FR 22945 - Notice of Open Public Hearing

    Science.gov (United States)

    2011-04-25

    ... examine China's policies regarding intellectual property rights and indigenous innovation, with a... in Washington, DC on May 4, 2011, to address ``China's Intellectual Property Rights and Indigenous... U.S.-CHINA ECONOMIC AND SECURITY REVIEW COMMISSION Notice of Open Public Hearing AGENCY: U.S...

  1. Bio-composites fabricated by sandwiching sisal fibers with polypropylene (PP)

    Energy Technology Data Exchange (ETDEWEB)

    Sosiati, H., E-mail: hsosiati@gmail.com [Nanomaterials Research Group, LPPT Universitas Gadjah Mada (Indonesia); Nahyudin, A., E-mail: ahmadnahyudin@yahoo.co.id; Fauzi, I., E-mail: ikhsannurfauzi@gmail.com; Wijayanti, D. A., E-mail: wijayantidwiastuti@gmail.com [Department of Physics, Faculty of Mathematics and Natural Sciences, Gadjah Mada University (Indonesia); Triyana, K., E-mail: triyana@ugm.ac.id [Nanomaterials Research Group, LPPT Universitas Gadjah Mada (Indonesia); Department of Physics, Faculty of Mathematics and Natural Sciences, Gadjah Mada University (Indonesia)

    2016-04-19

    Sisal fibers reinforced polypropylene (PP) composites were successfully fabricated using sandwiching sisal fibers with PP sheets. The ratio of fiber and polymer matrix was 50:50 (wt. %). Untreated short and long sisal fibers, and alkali treated short sisal fibers in 6% NaOH at 100°C for 1 and 3 h were used as reinforcement or fillers. A small amount (3 wt. %) of maleic anhydride grafted polypropylene (MAPP) was added as a coupling agent. Scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy were used to characterize the surface morphology and chemical composition of the fibers, respectively. Flexural test of sisal/PP composites was done according to ASTM D 790-02. The results showed that flexural strength of untreated long fiber reinforced composite is much higher than that of the untreated and alkali treated short fibers reinforced composites with and without the addition of MAPP. Alkalization related to fiber surface modification, fiber length/fiber orientation and a composite fabrication technique are important factors in contributing to the fiber distribution within the matrix, the bonding between the fiber and the matrix and the enhancement of flexural strength of the bio-composite.

  2. Bio-composites fabricated by sandwiching sisal fibers with polypropylene (PP)

    International Nuclear Information System (INIS)

    Sosiati, H.; Nahyudin, A.; Fauzi, I.; Wijayanti, D. A.; Triyana, K.

    2016-01-01

    Sisal fibers reinforced polypropylene (PP) composites were successfully fabricated using sandwiching sisal fibers with PP sheets. The ratio of fiber and polymer matrix was 50:50 (wt. %). Untreated short and long sisal fibers, and alkali treated short sisal fibers in 6% NaOH at 100°C for 1 and 3 h were used as reinforcement or fillers. A small amount (3 wt. %) of maleic anhydride grafted polypropylene (MAPP) was added as a coupling agent. Scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy were used to characterize the surface morphology and chemical composition of the fibers, respectively. Flexural test of sisal/PP composites was done according to ASTM D 790-02. The results showed that flexural strength of untreated long fiber reinforced composite is much higher than that of the untreated and alkali treated short fibers reinforced composites with and without the addition of MAPP. Alkalization related to fiber surface modification, fiber length/fiber orientation and a composite fabrication technique are important factors in contributing to the fiber distribution within the matrix, the bonding between the fiber and the matrix and the enhancement of flexural strength of the bio-composite.

  3. Bio-composites fabricated by sandwiching sisal fibers with polypropylene (PP)

    Science.gov (United States)

    Sosiati, H.; Nahyudin, A.; Fauzi, I.; Wijayanti, D. A.; Triyana, K.

    2016-04-01

    Sisal fibers reinforced polypropylene (PP) composites were successfully fabricated using sandwiching sisal fibers with PP sheets. The ratio of fiber and polymer matrix was 50:50 (wt. %). Untreated short and long sisal fibers, and alkali treated short sisal fibers in 6% NaOH at 100°C for 1 and 3 h were used as reinforcement or fillers. A small amount (3 wt. %) of maleic anhydride grafted polypropylene (MAPP) was added as a coupling agent. Scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy were used to characterize the surface morphology and chemical composition of the fibers, respectively. Flexural test of sisal/PP composites was done according to ASTM D 790-02. The results showed that flexural strength of untreated long fiber reinforced composite is much higher than that of the untreated and alkali treated short fibers reinforced composites with and without the addition of MAPP. Alkalization related to fiber surface modification, fiber length/fiber orientation and a composite fabrication technique are important factors in contributing to the fiber distribution within the matrix, the bonding between the fiber and the matrix and the enhancement of flexural strength of the bio-composite.

  4. The guanosine nucleotide (p)ppGpp initiates development and A-factor production in myxococcus xanthus.

    Science.gov (United States)

    Harris, B Z; Kaiser, D; Singer, M

    1998-04-01

    Guanosine 3'-di-5'-(tri)di-phosphate nucleotides [(p)ppGpp], synthesized in response to amino acid limitation, induce early gene expression leading to multicellular fruiting body formation in Myxococcus xanthus. A mutant (DK527) that fails to accumulate (p)ppGpp in response to starvation was found to be blocked in development prior to aggregation. By use of a series of developmentally regulated Tn5lac transcriptional fusion reporters, the time of developmental arrest in DK527 was narrowed to within the few hours of development, the period of starvation recognition. The mutant is also defective in the production of A-factor, an early extracellular cell-density signal. The relA gene from Escherichia coli, which encodes a ribosome-dependent (p)ppGpp synthetase, rescues this mutant. We also demonstrate that inactivation of the M. xanthus relA homolog blocks development and the accumulation of (p)ppGpp. Moreover, the wild-type allele of Myxococcus relA rescues DK527. These observations support a model in which accumulation of (p)ppGpp, in response to starvation, initiates the program of fruiting body development, including the production of A-factor.

  5. b-flavour tagging in pp collisions

    CERN Multimedia

    Birnkraut, Alex

    2015-01-01

    An essential ingredient of all time-dependent CP violation studies of B mesons is the ability to tag the initial flavour of the B meson. The harsh environment of 7 and 8 TeV pp collisions makes this a particularly difficult enterprise. We report progresses in the flavour tagging of B0 and Bs mesons, including developments of novel techniques like the use of an opposite side charm tagger.

  6. Mechanical properties of PA6/PP compatibilized nanocomposites using a twin screw extruder

    Science.gov (United States)

    De Almeida, M. F.; Correia, Aldina; e Silva, Eliana Costa; Lopes, I. Cristina

    2017-11-01

    In this article, a new approach to study the compatibilization effect of organophilic clays in PA6/PP polymer blends through experimental results of mechanical tests is presented. This study focus on the description of the interphase in compatibilization by addition of the organoclays C15A and C30B into the polymer PA6/PP blend by melt compounding using a Twin Screw Extruder. The experimental results variations are studied, by addition of the organoclays in uncompatibilized polymer blend, using non-parametric analysis of variance (Kruskal-Wallis Test). For all the experimental results, significant differences are identified between the types of polymer blends. It was observed the compatibilization effect of both organophilic clays, being the differences most evident in the presence of PP modified.

  7. A free radical-generating system regulates AβPP metabolism/processing: involvement of the ubiquitin/proteasome and autophagy/lysosome pathways.

    Science.gov (United States)

    Recuero, María; Munive, Victor A; Sastre, Isabel; Aldudo, Jesús; Valdivieso, Fernando; Bullido, María J

    2013-01-01

    Oxidative stress is an early event in the pathogenesis of Alzheimer's disease (AD). We previously reported that, in SK-N-MC cells, the xanthine/xanthine oxidase (X-XOD) free radical generating system regulates the metabolism/processing of the amyloid-β protein precursor (AβPP). Oxidative stress alters the two main cellular proteolytic machineries, the ubiquitin/proteasome (UPS) and the autophagy/lysosome systems, and recent studies have established connections between the malfunctioning of these and the pathogenesis of AD. The aim of the present work was to examine the involvement of these proteolytic systems in the regulation of AβPP metabolism by X-XOD. The proteasome inhibitor MG132 was found to accelerate the metabolism/processing of AβPP promoted by X-XOD because it significantly enhances the secretion of α-secretase-cleaved soluble AβPP and also the levels of both carboxy-terminal fragments (CTFs) produced by α- and β-secretase. Further, MG132 modulated the intracellular accumulation of holo-AβPP and/or AβPP CTFs. This indicates that the X-XOD modulation of AβPP metabolism/processing involves the UPS pathway. With respect to the autophagy/lysosome pathway, the AβPP processing and intracellular location patterns induced by X-XOD treatment closely resembled those produced by the lysosome inhibitor ammonium chloride. The present results suggest that the regulation of AβPP metabolism/processing by mild oxidative stress requires UPS activity with a simultaneous reduction in that of the autophagy/lysosome system.

  8. pp wave big bangs: Matrix strings and shrinking fuzzy spheres

    International Nuclear Information System (INIS)

    Das, Sumit R.; Michelson, Jeremy

    2005-01-01

    We find pp wave solutions in string theory with null-like linear dilatons. These provide toy models of big bang cosmologies. We formulate matrix string theory in these backgrounds. Near the big bang 'singularity', the string theory becomes strongly coupled but the Yang-Mills description of the matrix string is weakly coupled. The presence of a second length scale allows us to focus on a specific class of non-Abelian configurations, viz. fuzzy cylinders, for a suitable regime of parameters. We show that, for a class of pp waves, fuzzy cylinders which start out big at early times dynamically shrink into usual strings at sufficiently late times

  9. Asymmetry of prompt photon production in polarized pp collisions at RHIC

    International Nuclear Information System (INIS)

    Skoro, G.P.; Zupan, M.; Tokarev, M.V.

    1999-01-01

    The prompt photon production in polarized pp collision at high energies is studied. The double-spin asymmetry A LL of the process of calculated by using the Monte Carlo code SPHINX. A possibility to discriminate the spin-dependent gluon distributions and to determine the sign of ΔG id discussed. A detailed study of the expected background, such as π 0 production and decay, is given. Predictions for the longitudinal asymmetry A LL of the prompt photons and π 0 -meson production in the polarized pp collisions at RHIC energies have been made

  10. The PP ampersand L Nuclear Department model for conducting self-assessments

    International Nuclear Information System (INIS)

    Murthy, M.L.R.; Vernick, H.R.; Male, A.M.; Burchill, W.E.

    1995-01-01

    The nuclear department of Pennsylvania Power ampersand Light Company (PP ampersand L) has initiated an aggressive, methodical, self-assessment program. Self-assessments are conducted to prevent problems, improve performance, and monitor results. The assessment activities are conducted by, or for, an individual having responsibility for performing the work being assessed. This individual, or customer, accepts ownership of the assessment effort and commits to implementing the recommendations agreed on during the assessment. This paper discusses the main elements of the assessment model developed by PP ampersand L and the results the model has achieved to date

  11. Damping of forward neutrons in pp collisions

    International Nuclear Information System (INIS)

    Kopeliovich, B. Z.; Potashnikova, I. K.; Schmidt, Ivan; Soffer, J.

    2008-01-01

    We calculate absorptive corrections to single pion exchange in the production of leading neutrons in pp collisions. Contrary to the usual procedure of convolving the survival probability with the cross section, we apply corrections to the spin amplitudes. The nonflip amplitude turns out to be much more suppressed by absorption than the spin-flip one. We identify the projectile proton Fock state responsible for the absorptive corrections as a color octet-octet 5-quarks configuration. Calculations within two very different models, color-dipole light-cone description, and in hadronic representation, lead to rather similar absorptive corrections. We found a much stronger damping of leading neutrons than in some of previous estimates. Correspondingly, the cross section is considerably smaller than was measured at ISR. However, comparison with recent measurements by the ZEUS collaboration of neutron production in deep-inelastic scattering provides a strong motivation for challenging the normalization of the ISR data. This conjecture is also supported by preliminary data from the NA49 experiment for neutron production in pp collisions at SPS.

  12. Strangeness production in AA and pp collisions

    Energy Technology Data Exchange (ETDEWEB)

    Castorina, Paolo [Universita di Catania, Dipartimento di Fisica ed Astronomia, Catania (Italy); INFN, Catania (Italy); Satz, Helmut [Universitaet Bielefeld, Fakultaet fuer Physik, Bielefeld (Germany)

    2016-07-15

    Boost-invariant hadron production in high-energy collisions occurs in causally disconnected regions of finite space-time size. As a result, globally conserved quantum numbers (charge, strangeness, baryon number) are conserved locally in spatially restricted correlation clusters. Their size is determined by two time scales: the equilibration time specifying the formation of a quark-gluon plasma, and the hadronization time, specifying the onset of confinement. The expected values for these scales provide the theoretical basis for the suppression observed for strangeness production in elementary interactions (pp, e{sup +}e{sup -}) below LHC energies. In contrast, the space-time superposition of individual collisions in high-energy heavy-ion interactions leads to higher energy densities, resulting in much later hadronization and hence much larger hadronization volumes. This largely removes the causality constraints and results in an ideal hadronic resonance gas in full chemical equilibrium. In the present paper, we determine the collision energies needed for that; we also estimate when pp collisions reach comparable hadronization volumes and thus determine when strangeness suppression should disappear there as well. (orig.)

  13. A pp32-retinoblastoma protein complex modulates androgen receptor-mediated transcription and associates with components of the splicing machinery

    International Nuclear Information System (INIS)

    Adegbola, Onikepe; Pasternack, Gary R.

    2005-01-01

    We have previously shown pp32 and the retinoblastoma protein interact. pp32 and the retinoblastoma protein are nuclear receptor transcriptional coregulators: the retinoblastoma protein is a coactivator for androgen receptor, the major regulator of prostate cancer growth, while pp32, which is highly expressed in prostate cancer, is a corepressor of the estrogen receptor. We now show pp32 increases androgen receptor-mediated transcription and the retinoblastoma protein modulates this activity. Using affinity purification and mass spectrometry, we identify members of the pp32-retinoblastoma protein complex as PSF and nonO/p54nrb, proteins implicated in coordinate regulation of nuclear receptor-mediated transcription and splicing. We show that the pp32-retinoblastoma protein complex is modulated during TPA-induced K562 differentiation. Present evidence suggests that nuclear receptors assemble multiprotein complexes to coordinately regulate transcription and mRNA processing. Our results suggest that pp32 and the retinoblastoma protein may be part of a multiprotein complex that coordinately regulates nuclear receptor-mediated transcription and mRNA processing

  14. Catalytic activity of a novel serine/threonine protein phosphatase PP5 from Leishmania major

    Directory of Open Access Journals (Sweden)

    Norris-Mullins Brianna

    2014-01-01

    Full Text Available Leishmaniasis is a vector-borne disease caused by protozoan parasites of the genus Leishmania. Our knowledge of protein phosphatases (PPs and their implication in signaling events is very limited. Here we report the expression, characterization and mutagenesis analysis of a novel protein phosphatase 5 (PP5 in Leishmania major. Recombinant PP5 is a bona fide phosphatase and is enzymatically active. Site-directed mutagenesis revealed auto-inhibitory roles of the N-terminal region. This is a rational first approach to understand the role of PP5 in the biology of the parasite better as well as its potential future applicability to anti-parasitic intervention.

  15. Coulombic and radiative decay rates of the resonances of the exotic molecular ions ppμ, ppπ, ddμ, ddπ, and dtμ

    International Nuclear Information System (INIS)

    Kilic, Senem; Karr, Jean-Philippe; Hilico, Laurent

    2004-01-01

    The bound levels and the resonances (energy and width of the excited levels) of ppμ-like exotic molecules for J=0 total angular momentum have been computed with an accuracy in the 10 -11 a.u. range, by numerical diagonalization of the complex rotated Hamiltonian in a variational sturmian basis set. For the resonances below the N=2 dissociation threshold, the x-ray spontaneous emission spectrum is computed from the wave functions. The radiative decay rate of the first resonance of ppμ is found to be 0.0713 ps -1 , close to half that of a pμ(2p) atom, as expected in a simple Born-Oppenheimer picture of a resonance

  16. Monitoring of nutrient limitation in growing E. coli: a mathematical model of a ppGpp-based biosensor.

    Science.gov (United States)

    Pokhilko, Alexandra

    2017-11-21

    E. coli can be used as bacterial cell factories for production of biofuels and other useful compounds. The efficient production of the desired products requires careful monitoring of growth conditions and the optimization of metabolic fluxes. To avoid nutrient depletion and maximize product yields we suggest using a natural mechanism for sensing nutrient limitation, related to biosynthesis of an intracellular messenger - guanosine tetraphosphate (ppGpp). We propose a design for a biosensor, which monitors changes in the intracellular concentration of ppGpp by coupling it to a fluorescent output. We used mathematical modelling to analyse the intracellular dynamics of ppGpp, its fluorescent reporter, and cell growth in normal and fatty acid-producing E. coli lines. The model integrates existing mechanisms of ppGpp regulation and predicts the biosensor response to changes in nutrient state. In particular, the model predicts that excessive stimulation of fatty acid production depletes fatty acid intermediates, downregulates growth and increases the levels of ppGpp-related fluorescence. Our analysis demonstrates that the ppGpp sensor can be used for early detection of nutrient limitation during cell growth and for testing productivity of engineered lines.

  17. Review of GIF PR and PP Evaluation Case Study for Application to Pyroprocessing

    Energy Technology Data Exchange (ETDEWEB)

    Kim, H. M.; Ahn, S. K.; Kwon, E. H.; Kim, H. D. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    This paper has summarized and reviewed the ESFR case study, as it relates to the application of the evaluation methods to pyroprocessing facilities as well as the sodium fast reactor fuel cycle in the future as a self-assessment study. The GIF PR and PP evaluation methodology and the case study both addressed physical protection, but this paper focuses only on proliferation resistance. It does not consider physical protection. The Generation IV International Forum (GIF) emphasizes proliferation resistance and physical protection (PR and PP) as one of the main aspects to be considered regarding future nuclear energy systems (NESs). As such, the PR and PP Working Group developed an evaluation methodology and applied it to the Example Sodium Fast Reactor (ESFR) as a case study. This paper has summarized and reviewed the ESFR case study, as it relates to the application of the evaluation methods to pyroprocessing facilities as well as the sodium fast reactor fuel cycle in the future as a self-assessment study. The GIF PR and PP evaluation methodology and the case study both addressed physical protection, but this paper focuses only on proliferation resistance. It does not consider physical protection.

  18. Review of GIF PR and PP Evaluation Case Study for Application to Pyroprocessing

    International Nuclear Information System (INIS)

    Kim, H. M.; Ahn, S. K.; Kwon, E. H.; Kim, H. D.

    2014-01-01

    This paper has summarized and reviewed the ESFR case study, as it relates to the application of the evaluation methods to pyroprocessing facilities as well as the sodium fast reactor fuel cycle in the future as a self-assessment study. The GIF PR and PP evaluation methodology and the case study both addressed physical protection, but this paper focuses only on proliferation resistance. It does not consider physical protection. The Generation IV International Forum (GIF) emphasizes proliferation resistance and physical protection (PR and PP) as one of the main aspects to be considered regarding future nuclear energy systems (NESs). As such, the PR and PP Working Group developed an evaluation methodology and applied it to the Example Sodium Fast Reactor (ESFR) as a case study. This paper has summarized and reviewed the ESFR case study, as it relates to the application of the evaluation methods to pyroprocessing facilities as well as the sodium fast reactor fuel cycle in the future as a self-assessment study. The GIF PR and PP evaluation methodology and the case study both addressed physical protection, but this paper focuses only on proliferation resistance. It does not consider physical protection

  19. Study on the β to α transformation of PP/POE blends with β-phase nucleating agent during the tensile deformation process

    International Nuclear Information System (INIS)

    Li Xiaoxi; Wu Haiyan; Wang Yong; Bai Hongwei; Liu Li; Huang Ting

    2010-01-01

    As a part of serial work about the toughening effect of elastomer and nucleating agent on polypropylene (PP), this work is focused on the microstructure changes of PP matrix in PP/elastomer blends with β-phase nucleating agent (β-NA) during the uniaxial tensile deformation process. The microstructure changes have been investigated through differential scanning calorimetry (DSC) and wide angle X-ray diffraction (WAXD) measurements. The results show that there is a transformation of β-PP to α-PP, which is dependent on the local strain of the tensile-deformed specimen during the deformation process. The bigger the local strain, the high the degree of the β → α transformation is. At the later stage, β-PP is completely changed into α-PP. The presence of elastomer, especially at high load, prevents such transformation, possibly leading to more β-PP participating in the later deformation process of the fracture, which most likely results in the great improvement of fracture toughness of PP/elastomer/β-NA. Further results show that the β → α transformation occurs mainly in the necking region of the specimen during the deformation process.

  20. Factors Affecting Pro- and Anti-Oxidant Properties of Fragments of the b-Protein Precursor (bPP): Implication for Alzheimer's Disease.

    Science.gov (United States)

    Andorn, Anne C.; Kalaria, Rajesh N.

    2000-06-01

    Oxidative stress may have a key pathogenetic role in neurodegenerative diseases including Alzheimer's disease (AD). While there is evidence that some amyloid-b (Ab) peptides can initiate oxidative stress at micromolar doses, there is also some evidence that oxidative stress increases the concentration of the b-protein precursor (bPP) and the potential for increased formation of the Ab peptides. The following studies were performed to test the hypothesis that fragments of bPP could be antioxidants and hence that oxidative stress might be an early event in AD. We found that several fragments of bPP, including the Ab peptides, inhibit ascorbate-stimulated lipid peroxidation (ASLP) in membrane fragment preparations of postmortem human brain. In contrast, other fragments of bPP enhance ASLP. These data indicate that bPP or fragments of bPP could play a key role in the redox status of cells and that alterations in bPP processing could have profound effects on the cellular response to oxidative stress.

  1. High Energy pp Elastic Scattering in Condensate Enclosed Chiral Bag Model and TOTEM Elastic Measurements at LHC at 7 TeV

    CERN Document Server

    Islam, M M

    2013-01-01

    We study high energy $\\small{\\rm{pp}}$ and $\\small{\\rm{\\bar {p}p}}$ elastic scattering in the TeV region based on an effective field theory model of the proton. We phenomenologically investigate the main processes underlying elastic scattering and quantitatively describe the measured elastic d$\\small{\\sigma}$/dt at energies 7.0 TeV (LHC $\\small{\\rm{pp}}$), 1.96 TeV (Tevatron $\\small{\\rm{\\bar {p}p}}$), and 0.630 TeV (SPS $\\small{\\rm{\\bar {p}p}}$). Finally, we give our prediction for $\\small{\\rm{pp}}$ elastic d$\\small{\\sigma}$/dt at 14 TeV that will be measured by the TOTEM Collaboration.

  2. Evaluation of biodegradation of bionanocomposites of PHB/PP-g-MA/vermiculite

    International Nuclear Information System (INIS)

    Mesquita, P.J.P. de; Alves, T.S.; Barbosa, R.; Andrade, D. de L.A.C.S.

    2014-01-01

    In this work, we evaluated the process of biodegradation of PHB bionanocomposites/PP-g-MA/clay. Films were prepared with compositions of 5% PP-g-MA and 3% clay (BIO5); and 2.5% PP-g-MA and 3% clay (BIO2.5). The biodegradation test was conducted according to ASTM G 160-03 for a period of 86 days. The evaluation of biodegradation was performed by optical microscopy (MO), loss of mass, FTIR and XRD. The bionanocomposites presented change of coloration and appearance of fissures. As for loss in mass in the system presented loss of BIO2,5 22.5% and 25.9% BIO5, for 86 days of simulated soil exposure. We also observed by FTIR sharp reduction in intensity of the band corresponding to the C = O groups, indicating that the microbial attack promoted cleavage of the ester group links. By XRD, reduction in the intensity of the peaks and enlargements of the same with increasing exposure time, proving the biodegradation behavior of bionanocomposites. (author)

  3. ANALISIS KEPUASAN PENGGUNA JASA PEMELIHARAAN DAN PERBAIKAN ATAS PELAYANAN UPT-PP (UNIT PELAKSANA TEKNIS PEMELIHARAAN DAN PERBAIKAN POLITEKNIK NEGERI BALI

    Directory of Open Access Journals (Sweden)

    I Made Aryana

    2016-01-01

    Full Text Available ABSTRACT: PNBis avocational educationinstitution. Withvocationalpredicate,PNBhavediverse learningfacility. In order forthese assetsremainin top condition(ready to use, there should bea specialunit thathandlesmaintenance andrepairissues. UPT-PP (Unit Pelaksana Teknis Pemeliharaan dan Perbaikan isone of the unitsinPNBwhichhas a function asimplementingmaintenanceandrepairsof allassets, and all equipment usedin the activities ofthe learning process. UPT-PP has thefunctions andresponsibilitiesarequite heavyand vitalin supportingthe smoothlearning activitiesboth theory andpractice. This situation demandsUPT-PP shouldhavegoodhuman resources, competent, reliable andshould be supportedbythe provision ofhardwareandsoftwarethat isadequate. This studyaims to determinethe value ofservice usersatisfaction levelof maintenanceandrepair ofservices givenbyUPT-PP Politeknik Negeri Baliandidentify the factorsthat need attentionin order to increaseuser satisfactionwith the servicesUPT-PP Politeknik Negeri Bali. Retrieval of dataobtained from thespread ofthe questioner aboutfacts andrealityassociatedwith service qualityanduser expectationsUPT-PP Politeknik Negeri Bali. While the calculationof thecorrespondence between thelevel of quality anduser expectationsUPT-PP isthe comparison ofthe qualityweightwith the weight ofexpectations/interests. This conformity levelwillshow the level ofuser satisfactionwith the services. Results ofa descriptiveanalysis ofuser satisfactionwith the servicesUPT-PP can be determined bythe value ofthe conformity level. After analysis, the conformitylevelofeachdimensionis obtainedfromthe tangiblevalue81.08%, conformity level of reliability79.04%, conformity level of responsiveness to the valueof81.09%, theassurancedimensionwithvalue84.20% anddimensionsof empathywith the conformity value83.23%. Fromfivedimensions ofconformity level assessment between service qualityexpectationsof service usersUPT-PP Politeknik Negeri Bali is81

  4. Fasting and meal-induced CCK and PP secretion following intragastric balloon treatment for obesity.

    Science.gov (United States)

    Mathus-Vliegen, Elisabeth M H; de Groot, Gerrit H

    2013-05-01

    Satiety is centrally and peripherally mediated by gastrointestinal peptides and the vagal nerve. We aimed to investigate whether intragastric balloon treatment affects satiety through effects on fasting and meal-stimulated cholecystokinin (CCK) and pancreatic polypeptide (PP) secretion. Patients referred for obesity treatment were randomised to 13 weeks of sham treatment followed by 13 weeks of balloon treatment (group 1; sham/balloon) or to twice a 13-week period of balloon treatment (group 2; balloon/balloon). Blood samples were taken for fasting and meal-stimulated CCK and PP levels at the start (T0) and after 13 (T1) and 26 (T2) weeks. Patients filled out visual analogue scales (VAS) to assess satiety. Forty-two patients (35 females, body weight 125.1 kg, BMI 43.3 kg/m(2)) participated. In group 1, basal CCK levels decreased but meal-stimulated response remained unchanged after 13 weeks of sham treatment. In group 2, basal and meal-stimulated CCK levels decreased after 13 weeks of balloon treatment. At the end of the second 13-week period, when group 1 had their first balloon treatment, they duplicated the initial 13-week results of group 2, whereas group 2 continued their balloon treatment and reduced meal-stimulated CCK release. Both groups showed reduced meal-stimulated PP secretions at T1 and T2 compared to T0. Changes in diet composition and VAS scores were similar. Improvements in glucose homeostasis partly explained the PP results. The reduced CCK and PP secretion after balloon positioning was unexpected and may reflect delayed gastric emptying induced by the balloon. Improved glucose metabolism partly explained the reduced PP secretion. Satiety and weight loss were not adversely influenced by these hormonal changes.

  5. Basic Research on Adaptive Model Algorithmic Control

    Science.gov (United States)

    1985-12-01

    Control Conference. Richalet, J., A. Rault, J.L. Testud and J. Papon (1978). Model predictive heuristic control: applications to industrial...pp.977-982. Richalet, J., A. Rault, J. L. Testud and J. Papon (1978). Model predictive heuristic control: applications to industrial processes

  6. Effect of injection molding parameters on nanofillers dispersion in masterbatch based PP-clay nanocomposites

    Directory of Open Access Journals (Sweden)

    J. Soulestin

    2012-03-01

    Full Text Available The effect of injection molding parameters (screw rotational speed, back pressure, injec-tion flow rate and holding pressure on the nanofiller dispersion of melt-mixed PP/clay nanocomposites was investigated. The nanocomposites containing 4 wt% clay were obtained by dilution of a PP/clay masterbatch into a PP matrix. The evaluation of the dispersion degree was obtained from dynamic rheological measurements. The storage modulus and complex viscosity exhibit significant dependence on the injection molding parameters. PP/clay nanocomposite molded using more severe injection parameters (high shear and long residence time displays the highest storage modulus and complex viscosity, which illustrates the improved dispersion of clay platelets. This better dispersion leads to better mechanical properties particularly higher Young modulus, tensile strength and unnotched impact strength. A Taguchi analysis was used to identify the influence of individual process parameters. The major individual parameter is the injection flow rate, whose increase improves nanoclay dispersion. The combination of high back pressure and high screw rotational speed is also necessary to optimize the dispersion of clay nanoplatelets.

  7. Activation of the oxidative stress regulator PpYap1 through conserved cysteine residues during methanol metabolism in the yeast Pichia pastoris.

    Science.gov (United States)

    Yano, Taisuke; Yurimoto, Hiroya; Sakai, Yasuyoshi

    2009-06-01

    The methylotrophic yeast Pichia pastoris can grow on methanol as sole source of carbon and energy. The first reaction in yeast methanol metabolism, catalyzed by an abundant peroxisomal enzyme, alcohol oxidase, generates high levels of H(2)O(2), but the oxidative stress response during methanol metabolism has not been elucidated. In this study, we isolated the Yap1 homolog of P. pastoris (PpYap1) and analyzed the properties of a PpYAP1-disruption strain. The PpYap1 transcription factor is activated after exposure to various reactive agents, and therefore functions as a regulator of the redox system in P. pastoris. We have also identified PpGPX1, the unique glutathione peroxidase-encoding gene in P. pastoris whose expression is induced by PpYap1. PpGpx1, but not the ScTsa1 or SpTpx1 homolog PpTsa1, functions as a H(2)O(2) sensor and activates PpYap1. This study is the first demonstration of a yeast Yap1 family protein activated during conventional metabolism.

  8. Type II pp-wave matrix models from point-like gravitons

    International Nuclear Information System (INIS)

    Lozano, Yolanda; RodrIguez-Gomez, Diego

    2006-01-01

    The BMN Matrix model can be regarded as a theory of coincident M-theory gravitons, which expand by Myers dielectric effect into the 2-sphere and 5-sphere giant graviton vacua of the theory. In this note we show that, in the same fashion, Matrix String theory in Type IIA pp-wave backgrounds arises from the action for coincident Type IIA gravitons. In Type IIB, we show that the action for coincident gravitons in the maximally supersymmetric pp-wave background gives rise to a Matrix model which supports fuzzy 3-sphere giant graviton vacua with the right behavior in the classical limit. We discuss the relation between our Matrix model and the Tiny Graviton Matrix theory

  9. Asymmetry of prompt photon production in polarized pp collisions at RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Skoro, G.P.; Zupan, M. [Institute of Nuclear Science ' Vinca' , Faculty of Physics University of Belgrade, (Yugoslavia); Tokarev, M.V. [Laboratory of High Energies, Joint Institute of Nuclear Research Dubna, Moscow Region (Russian Federation)

    1999-08-01

    The prompt photon production in polarized pp collision at high energies is studied. The double-spin asymmetry A{sub LL} of the process of calculated by using the Monte Carlo code Sphinx. A possibility to discriminate the spin-dependent gluon distributions and to determine the sign of {delta}G is discussed. A detailed study of the expected background, such as {pi}{sup 0} production and decay, is given. Predictions for the longitudinal asymmetry A{sub LL} of the prompt photons and {pi}{sup 0}-meson production in the polarized pp collisions at RHIC energies have been made.

  10. Catalytic and glycan-binding abilities of ppGalNAc-T2 are regulated by acetylation

    DEFF Research Database (Denmark)

    Zlocowski, Natacha; Sendra, Victor G; Lorenz, Virginia

    2011-01-01

    Post-translational acetylation is an important molecular regulatory mechanism affecting the biological activity of proteins. Polypeptide GalNAc transferases (ppGalNAc-Ts) are a family of enzymes that catalyze initiation of mucin-type O-glycosylation. All ppGalNAc-Ts in mammals are type II...

  11. pp production cross sections and the constraint method

    International Nuclear Information System (INIS)

    Anjos, J.C.; Santoro, A.F.S.; Souza, M.H.G.

    1983-01-01

    A method of constructing production cross sections that satisfy the constraints represented by the first few moments is shown to give an excellent account of the data when applied to the high energy pp production cross section ν sub(n) (s) plotted as functions of n. (Author) [pt

  12. pp elastic scattering at LHC energies

    Energy Technology Data Exchange (ETDEWEB)

    Kohara, A.K.; Ferreira, E.; Kodama, T. [Universidade Federal do Rio de Janeiro, Instituto de Fisica, C.P. 68528, Rio de Janeiro, RJ (Brazil)

    2014-11-15

    Using a unified analytic representation for the elastic scattering amplitudes of pp scattering valid for all energies above 20 GeV, the behavior of observables in the LHC collisions in the range √(s) = 2.76-14 TeV is discussed. After the precise description of dσ/dt at 7 TeV, we discuss the energy dependence of the amplitudes and expect that the proposed analytical forms give equally good predictions for the future experiments. (orig.)

  13. pp elastic scattering at LHC energies

    International Nuclear Information System (INIS)

    Kohara, A.K.; Ferreira, E.; Kodama, T.

    2014-01-01

    Using a unified analytic representation for the elastic scattering amplitudes of pp scattering valid for all energies above 20 GeV, the behavior of observables in the LHC collisions in the range √(s) = 2.76-14 TeV is discussed. After the precise description of dσ/dt at 7 TeV, we discuss the energy dependence of the amplitudes and expect that the proposed analytical forms give equally good predictions for the future experiments. (orig.)

  14. Diffractively Produced Charm Final States in 800-GeV/c pp Collisions

    Science.gov (United States)

    Wang, M. H.; Berisso, M. C.; Christian, D. C.; Félix, J.; Gara, A.; Gottschalk, E.; Gutiérrez, G.; Hartouni, E. P.; Knapp, B. C.; Kreisler, M. N.; Lee, S.; Markianos, K.; Moreno, G.; Reyes, M. A.; Sosa, M.; Wehmann, A.; Wesson, D.

    2001-08-01

    We report the first observation of diffractively produced open charm in 800-GeV/c pp collisions of the type pp-->pD*X. We measure cross sections of σdiff(D*+) = (0.185+/-0.044+/-0.054) μb and σdiff(D*-) = (0.174+/-0.034+/-0.029) μb. Our measurements are based on 4.3×109 events recorded by FNAL E690 in the fixed-target run of 1991. We compare our results with previous fixed-target charm experiments.

  15. A study on thermal and mechanical properties of mechanically milled HDPE and PP

    International Nuclear Information System (INIS)

    Can, S.; Tan, S.

    2003-01-01

    In this study, mechanical mixing of HDPE and PP was performed via ball milling. Prepared compositions were 75/25 , 50/50 , 25/75 w/w HDPE/PP. Milling time and ball to powder ratio (B/P) were kept constant and system was cooled by adding solid CO 2 to improve the milling efficiency. To compare these systems with traditional methods, mixtures were also melt mixed by Brabender Plasti-Corder. Both milled and melt mixed systems were examined with DSC for thermal properties and tensile testing for mechanical properties Results are discussed by comparing milled , melt mixed and as-received polymers. It is observed that, unlike ball milled systems' in melt mixed systems mechanical properties are composition dependent. In addition , ball milling results in amorphization of both polymers and very high amounts of PP (75wt %) creates very amorphous HDPE structure. (Original)

  16. Evaluation of the degree of dispersion of organoclay on nanocomposites with PP/EPDM

    International Nuclear Information System (INIS)

    Braga, F.C.F.; Oliveira, M.G.

    2010-01-01

    Nanocomposites of thermoplastic elastomer (TPE) composed by PP/EPDM 1/1 blend and organoclay were obtained by the melt intercalation in an internal chamber mix. Initially, a masterbatch of maleinized polypropylene (PP-MA) and clay modified with alkyl ammonium salt in the ratio 3:1 was prepared, and then, added to TPE matrix to obtain loads of 2,5; 5 and 7 wt% of clay in the nanocomposite. The dispersion degree of clay in TPE matrix was evaluated by X-ray diffraction and parallel plate rheometry. The intercalation/exfoliate degree or the degree of dispersion varied with clay content, as observed by X-ray diffraction. This behavior was confirmed by the profile of the curves of elastic modulus versus frequency, which presented different slopes in the region of low frequency, due to the presence of clay and PP-MA. (author)

  17. Anisotropy and compression/tension asymmetry of PP containing soft and hard particles and short glass fibers

    Directory of Open Access Journals (Sweden)

    A. M. Hartl

    2015-07-01

    Full Text Available Polypropylene (PP composites are used in a wide range of structural applications. Except for fiber reinforced PP, most PP particle composites are commonly considered to be isotropic or at least quasi-isotropic. In this paper, however, the anisotropy of several PP composites containing soft (rubber and hard (talc particles and glass fibers is characterized in detail in terms of the material microstructure as well as the resulting mechanical properties in monotonic tensile and compressive experiments. The microstructural investigations showed that all composites displayed a certain surface-core layer structure of distinctly different orientation patterns and with a higher degree of orientation in the surface layer. Also in mechanical testing an anisotropic behavior was observed with the degree of anisotropy being more pronounced in tension than compression. Moreover, the compression/tension asymmetry also strongly depends on filler type and orientation.

  18. Distinct functional domains within the acidic cluster of tegument protein pp28 required for trafficking and cytoplasmic envelopment of human cytomegalovirus.

    Science.gov (United States)

    Seo, Jun-Young; Jeon, Hyejin; Hong, Sookyung; Britt, William J

    2016-10-01

    Human cytomegalovirus UL99-encoded tegument protein pp28 contains a 16 aa acidic cluster that is required for pp28 trafficking to the assembly compartment (AC) and the virus assembly. However, functional signals within the acidic cluster of pp28 remain undefined. Here, we demonstrated that an acidic cluster rather than specific sorting signals was required for trafficking to the AC. Recombinant viruses with chimeric pp28 proteins expressing non-native acidic clusters exhibited delayed viral growth kinetics and decreased production of infectious virus, indicating that the native acidic cluster of pp28 was essential for wild-type virus assembly. These results suggested that the acidic cluster of pp28 has distinct functional domains required for trafficking and for efficient virus assembly. The first half (aa 44-50) of the acidic cluster was sufficient for pp28 trafficking, whereas the native acidic cluster consisting of aa 51-59 was required for the assembly of wild-type levels of infectious virus.

  19. Synthesis of electron beam grafted poly-propylene (PP) membranes for selective adsorption of uranium from sea water

    International Nuclear Information System (INIS)

    Bhardwaj, Y.K.; Virendra Kumar; Sabharwal, S.

    2001-01-01

    Graft co polymerisation of Acrylonitrile (AN) onto porous polypropylene (PP) by post irradiation technique using electron beam (EB) irradiation were studied with regards to various parameters of importance like grafting time, dose rate and horizontal stacking. Grafting of AN causes hardening as well as yellow colouration of the white flexible PP substrate sheets. Grafting reaches saturation limits of ∼130 % after grafting for 2-3 hours and no significant increase in grafting extents is seen after this period. Higher grafting levels are achieved at low dose rates. Keeping the ratio of volume of grafting solution and weight of PP substrate constant, simultaneous grafting of 10-12 PP sheets can be carried out by horizontal stacking without much variation in the grafting limits between the stacked sheets. (author)

  20. Evidence that pp60/sup src/, the product of the Rous sarcoma virus src gene, undergoes autophosphorylation

    International Nuclear Information System (INIS)

    Purchio, A.F.

    1982-01-01

    pp60/sup src/, the product of the Rous sarcoma virus src gene, was purified greater than 100,000-fold by a combination of ion-exchange and immunoaffinity chromatography. Incubation of pp60/sup src/ purified in this fashion with [ 32 P-γ]ATP resulted in a single 32 P-labeled protein when analyzed by sodium dodecyl sulfate-polyacryl-amide gel electrophoresis. Staining of these gels with silver nitrate showed a predominant 60,000-dalton polypeptide which migrated with the protein labeled with 32 P in vitro. Partial digestion of this protein with V8 protease after in vitro iodination indicated that it was pp60/sup src/. These results suggest that pp60/sup src/ is able to autophosphorylate

  1. Current status and future directions of development of PR/PP evaluation methodology

    International Nuclear Information System (INIS)

    Kim, D. Y.; Kwon, E. H.; Kim, H. D.

    2012-01-01

    A mandatory design requirement for the introduction of generation IV nuclear energy systems (NESs) is defined as the characteristic of a nuclear energy system that impedes the diversion or undeclared production of nuclear material, or misuse of technology, by State in order to acquire nuclear weapons or other nuclear explosive devices. The same report also defines physical protection (PP) as the use of technical, administrative, and operational measures to prevent the theft of nuclear/radioactive material for the purpose of producing nuclear weapons, producing nuclear devices for nuclear terrorism, or using the facility or transportation system for radiological sabotage. Since the early 1970s right after the Indian nuclear test, the international community has recognized the limits of political and diplomatic means to prevent overt proliferation by states and looked for ways to incorporate technical features that are inherent in NESs. As a first step, active research has been conducted to develop a methodology to evaluate PR and PP components of NESs and has now been reduced to two main R and D streams: the Generation IV International Forum (GIF) and International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO). (Currently, GIF and INPRO are leading the debate as major projects for PR and PP evaluation methods.) This paper presents an overview of the R and D accomplishments during the development of PR and PP evaluation methodology. It also suggests some directions for future research

  2. Current status and future directions of development of PR/PP evaluation methodology

    Energy Technology Data Exchange (ETDEWEB)

    Kim, D. Y.; Kwon, E. H.; Kim, H. D. [KAERI, Daejeon (Korea, Republic of)

    2012-10-15

    A mandatory design requirement for the introduction of generation IV nuclear energy systems (NESs) is defined as the characteristic of a nuclear energy system that impedes the diversion or undeclared production of nuclear material, or misuse of technology, by State in order to acquire nuclear weapons or other nuclear explosive devices. The same report also defines physical protection (PP) as the use of technical, administrative, and operational measures to prevent the theft of nuclear/radioactive material for the purpose of producing nuclear weapons, producing nuclear devices for nuclear terrorism, or using the facility or transportation system for radiological sabotage. Since the early 1970s right after the Indian nuclear test, the international community has recognized the limits of political and diplomatic means to prevent overt proliferation by states and looked for ways to incorporate technical features that are inherent in NESs. As a first step, active research has been conducted to develop a methodology to evaluate PR and PP components of NESs and has now been reduced to two main R and D streams: the Generation IV International Forum (GIF) and International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO). (Currently, GIF and INPRO are leading the debate as major projects for PR and PP evaluation methods.) This paper presents an overview of the R and D accomplishments during the development of PR and PP evaluation methodology. It also suggests some directions for future research.

  3. The Role of PP2A Methylation in Susceptibility and Resistance to TBI and AD-Induced Neurodegeneration

    Science.gov (United States)

    2013-09-01

    to a depth of 1.30 mm) (Paxinos and Franklin, 2004) and fixed to the skull with acrylic dental cement (Paladur). Mice were administered 5 mg/kg...loaded per lane from each sample on a 1mm Nupage 4-12% Bis -Tris gel (Invitrogen). Resolved proteins were transferred to PVDF membrane using an I-blot...activity by controlling its subunit composition . The typical PP2A holoenzyme is a heterotrimer composed of a catalytic subunit, a structural subunit

  4. Combat Systems Vision 2030 Conceptual Design of Control Structures for Combat Systems

    Science.gov (United States)

    1992-02-01

    IEEE, 68(6), pp. 644-654, 1980. 26. Singh , M. G.; Titli, A.; and Malinowski, K.; "Decentralized Control Design: An Overview," Large Scale Systems...IFAC Symposium, pp. 335-339, 1988. 40. Cameron, E. J.; Petschenik, N. H.; Ruston, Lillian; Shah, Swati ; and Srinidhi, Hassan, (Bell Communications

  5. High-Pressure NMR and SAXS Reveals How Capping Modulates Folding Cooperativity of the pp32 Leucine-rich Repeat Protein.

    Science.gov (United States)

    Zhang, Yi; Berghaus, Melanie; Klein, Sean; Jenkins, Kelly; Zhang, Siwen; McCallum, Scott A; Morgan, Joel E; Winter, Roland; Barrick, Doug; Royer, Catherine A

    2018-04-27

    Many repeat proteins contain capping motifs, which serve to shield the hydrophobic core from solvent and maintain structural integrity. While the role of capping motifs in enhancing the stability and structural integrity of repeat proteins is well documented, their contribution to folding cooperativity is not. Here we examined the role of capping motifs in defining the folding cooperativity of the leucine-rich repeat protein, pp32, by monitoring the pressure- and urea-induced unfolding of an N-terminal capping motif (N-cap) deletion mutant, pp32-∆N-cap, and a C-terminal capping motif destabilization mutant pp32-Y131F/D146L, using residue-specific NMR and small-angle X-ray scattering. Destabilization of the C-terminal capping motif resulted in higher cooperativity for the unfolding transition compared to wild-type pp32, as these mutations render the stability of the C-terminus similar to that of the rest of the protein. In contrast, deletion of the N-cap led to strong deviation from two-state unfolding. In both urea- and pressure-induced unfolding, residues in repeats 1-3 of pp32-ΔN-cap lost their native structure first, while the C-terminal half was more stable. The residue-specific free energy changes in all regions of pp32-ΔN-cap were larger in urea compared to high pressure, indicating a less cooperative destabilization by pressure. Moreover, in contrast to complete structural disruption of pp32-ΔN-cap at high urea concentration, its pressure unfolded state remained compact. The contrasting effects of the capping motifs on folding cooperativity arise from the differential local stabilities of pp32, whereas the contrasting effects of pressure and urea on the pp32-ΔN-cap variant arise from their distinct mechanisms of action. Copyright © 2018 Elsevier Ltd. All rights reserved.

  6. Production of the J/PSI in PIp and pp collisions

    International Nuclear Information System (INIS)

    Boreskov, K.G.; Turbiner, A.V.

    1978-01-01

    J/PSI production in pp collisions in the energy region from 70 GeV up to ISR energies is studied by means of the π-meson exchange model using the experimental data on J/PSI production in πp collisions. A new parametrization of inclusive cross section of the process πp → J/PSI + chi in a wide energy region is suggested. It is shown that the π-meson exchange model with parameters found analyzing the nucleon and Δ-isobar inclusive spectra, allows to describe the energy dependence and the shape of J/PSI spectra in pp collisions. The relation between the cross sections of J/PSI ass--ociated production with nucleon or Δ isobar is estimated. Possible quark-parton interpretation of the results is discussed

  7. Development and assessment of an e-learning course on breast imaging for radiographers: a stratified randomized controlled trial.

    Science.gov (United States)

    Moreira, Inês C; Ventura, Sandra Rua; Ramos, Isabel; Rodrigues, Pedro Pereira

    2015-01-05

    Mammography is considered the best imaging technique for breast cancer screening, and the radiographer plays an important role in its performance. Therefore, continuing education is critical to improving the performance of these professionals and thus providing better health care services. Our goal was to develop an e-learning course on breast imaging for radiographers, assessing its efficacy, effectiveness, and user satisfaction. A stratified randomized controlled trial was performed with radiographers and radiology students who already had mammography training, using pre- and post-knowledge tests, and satisfaction questionnaires. The primary outcome was the improvement in test results (percentage of correct answers), using intention-to-treat and per-protocol analysis. A total of 54 participants were assigned to the intervention (20 students plus 34 radiographers) with 53 controls (19+34). The intervention was completed by 40 participants (11+29), with 4 (2+2) discontinued interventions, and 10 (7+3) lost to follow-up. Differences in the primary outcome were found between intervention and control: 21 versus 4 percentage points (pp), Peffect in radiographers (23 pp vs 4 pp; P=.004) but was unclear in students (18 pp vs 5 pp; P=.098). Nonetheless, differences in students' posttest results were found (88% vs 63%; P=.003), which were absent in pretest (63% vs 63%; P=.106). The per-protocol analysis showed a higher effect (26 pp vs 2 pp; Pe-learning course is effective, especially for radiographers, which highlights the need for continuing education.

  8. pp32 (ANP32A expression inhibits pancreatic cancer cell growth and induces gemcitabine resistance by disrupting HuR binding to mRNAs.

    Directory of Open Access Journals (Sweden)

    Timothy K Williams

    Full Text Available The expression of protein phosphatase 32 (PP32, ANP32A is low in poorly differentiated pancreatic cancers and is linked to the levels of HuR (ELAV1, a predictive marker for gemcitabine response. In pancreatic cancer cells, exogenous overexpression of pp32 inhibited cell growth, supporting its long-recognized role as a tumor suppressor in pancreatic cancer. In chemotherapeutic sensitivity screening assays, cells overexpressing pp32 were selectively resistant to the nucleoside analogs gemcitabine and cytarabine (ARA-C, but were sensitized to 5-fluorouracil; conversely, silencing pp32 in pancreatic cancer cells enhanced gemcitabine sensitivity. The cytoplasmic levels of pp32 increased after cancer cells are treated with certain stressors, including gemcitabine. pp32 overexpression reduced the association of HuR with the mRNA encoding the gemcitabine-metabolizing enzyme deoxycytidine kinase (dCK, causing a significant reduction in dCK protein levels. Similarly, ectopic pp32 expression caused a reduction in HuR binding of mRNAs encoding tumor-promoting proteins (e.g., VEGF and HuR, while silencing pp32 dramatically enhanced the binding of these mRNA targets. Low pp32 nuclear expression correlated with high-grade tumors and the presence of lymph node metastasis, as compared to patients' tumors with high nuclear pp32 expression. Although pp32 expression levels did not enhance the predictive power of cytoplasmic HuR status, nuclear pp32 levels and cytoplasmic HuR levels associated significantly in patient samples. Thus, we provide novel evidence that the tumor suppressor function of pp32 can be attributed to its ability to disrupt HuR binding to target mRNAs encoding key proteins for cancer cell survival and drug efficacy.

  9. Chemical interaction and adhesion characteristics at the interface of metals (Cu, Ta) and low-k cyclohexane-based plasma polymer (CHexPP) films

    International Nuclear Information System (INIS)

    Kim, K.J.; Kim, K.S.; Lee, N.-E.; Choi, J.; Jung, D.

    2001-01-01

    Chemical interaction and adhesion characteristics between metals (Cu, Ta) and low-k plasma-treated cyclohexane-based plasma polymer (CHexPP) films were studied. In order to generate new functional groups that may contribute to the improvement of adhesion between metal and plasma polymer, we performed O 2 , N 2 , and H 2 /He mixture plasma treatment on the surfaces of CHexPP films. Chemical interactions at the interface between metals (Cu, Ta) and plasma-treated CHexPP films were analyzed by x-ray photoelectron spectroscopy. The effect of plasma treatment and thermal annealing on the adhesion characteristics was measured by a tape test and scratch test. The formation of new binding states on the surface of plasma-treated CHexPP films improved adhesion characteristics between metals and CHexPP films. Thermal annealing improves the adhesion property of Cu/CHexPP films, but degrades the adhesion property of Ta/CHexPP films

  10. Tensor hypercontracted ppRPA: Reducing the cost of the particle-particle random phase approximation from O(r 6) to O(r 4)

    International Nuclear Information System (INIS)

    Shenvi, Neil; Yang, Yang; Yang, Weitao; Aggelen, Helen van

    2014-01-01

    In recent years, interest in the random-phase approximation (RPA) has grown rapidly. At the same time, tensor hypercontraction has emerged as an intriguing method to reduce the computational cost of electronic structure algorithms. In this paper, we combine the particle-particle random phase approximation with tensor hypercontraction to produce the tensor-hypercontracted particle-particle RPA (THC-ppRPA) algorithm. Unlike previous implementations of ppRPA which scale as O(r 6 ), the THC-ppRPA algorithm scales asymptotically as only O(r 4 ), albeit with a much larger prefactor than the traditional algorithm. We apply THC-ppRPA to several model systems and show that it yields the same results as traditional ppRPA to within mH accuracy. Our method opens the door to the development of post-Kohn Sham functionals based on ppRPA without the excessive asymptotic cost of traditional ppRPA implementations

  11. Influence of electron beam Irradiation on PP/Piassava fiber composite prepared by melt extrusion process

    International Nuclear Information System (INIS)

    Gomes, Michelle G.; Ferreira, Maiara S.; Oliveira, Rene R.; Silva, Valquiria A.; Teixeira, Jaciele G.; Moura, Esperidiana A.B.

    2013-01-01

    In the latest years, the interest for the use of natural fibers in materials composites polymeric has increased significantly due to their environmental and technological advantages. Piassava fibers (Attalea funifera) have been used as reinforcement in the matrix of thermoplastic and thermoset polymers. In the present work (20%, in mass), piassava fibers with particle sizes equal or smaller than 250 μm were incorporated in the polypropylene matrix (PP) no irradiated and polypropylene matrix containing 10 % and 30 % of polypropylene treated by electron-beam radiation at 40 kGy (PP/PPi/Piassava). The composites PP/Piassava and PP/PPi/Piassava were prepared by using a twin screw extruder, followed by injection molding. The composite material samples obtained were treated by electron-beam radiation at 40 kGy, using a 1.5 MeV electron beam accelerator, at room temperature, in presence of air. After irradiation treatment, the irradiated and non-irradiated specimens tests samples were submitted to thermo-mechanical tests, melt flow index (MFI), sol-gel analysis, X-Ray diffraction (XRD) and scanning electron microscopy (SEM). (author)

  12. Radiation Effects on PP/PS Blends as a Model of Protection Effects by Aromatics

    International Nuclear Information System (INIS)

    Gluszewski, W.

    2006-01-01

    Polypropylene (PP) is the most popular polymer for the application in construction of medical devices, due to the hardness and temperature resistance. Unfortunately, the virgin PP is of low resistance towards ionizing radiation, already to sterilization doses and cannot be applied without additives. Another option is a blend with a second polymer, especially aromatic, and therefore polystyrene (PS) was applied. The classic case of protection in the aliphatic/aromatic system (benzene/cyclohexane in liquid or solid state) shows that the surface area and structure of the interphase is crucial for the effectiveness of energy transfer. Our blends of PP (virgin, F401 from Orlen-Olefins) with PS were prepared in a variety of ways, from mechanical blending, to radiation induced grafting. Two linac accelerators (10 MeV, 6-9 kW) were applied, with different shapes of electron beam, formed according to particular methods used for the investigation of effects; doses were 10-600 kGy. As in the classic case, the protection effect was quantisized from the curve of the effect vs 0-100% PP, 100-0 % PS. Main recognition of the protection effect has been done by the diffused reflection spectroscopy (DRS) developed in our Laboratory for the application to irradiated polymers. The dependence of intensity of bands in the DRS spectrum, attributed to keton groups, which are final products of oxidation, shows clearly the protection effect of PP, executed by PS. The second method of observation of radiation effects is gas chromatography (GC), applied for irradiation products analysis. The maximum sensitivity has been achieved using the instrument type GC 2014 by Shimadzu, with thermal conductivity detector, column packed with molecular sieves 5A. Radiation induced formation of gaseous produced at ambient and lower temperatures is unique in the field of chemistry of polymers. There is no form of energy, except ionizing radiation, to cause chemical reactions to produce a wide spectrum of low

  13. Analysis of nucleo-cytoplasmic shuttling of the proto-oncogene SET/I2PP2A

    NARCIS (Netherlands)

    Lam, B. Daniel; Anthony, Eloise C.; Hordijk, Peter L.

    2012-01-01

    SET/I2PP2A is a nuclear protein that was initially identified as an oncogene in human undifferentiated acute myeloid leukemia, fused to the nuclear porin Nup-214. In addition, SET is a potent inhibitior of the phosphatase PP2A. Previously, we proposed a model in which the small GTPase Rac1 recruits

  14. Shugoshin-1 balances Aurora B kinase activity via PP2A to promote chromosome bi-orientation

    NARCIS (Netherlands)

    Meppelink, Amanda; Kabeche, Lilian; Vromans, Martijn J M; Compton, Duane A; Lens, Susanne M A

    2015-01-01

    Correction of faulty kinetochore-microtubule attachments is essential for faithful chromosome segregation and dictated by the opposing activities of Aurora B kinase and PP1 and PP2A phosphatases. How kinase and phosphatase activities are appropriately balanced is less clear. Here, we show that a

  15. Defining Quantum Control Flow

    OpenAIRE

    Ying, Mingsheng; Yu, Nengkun; Feng, Yuan

    2012-01-01

    A remarkable difference between quantum and classical programs is that the control flow of the former can be either classical or quantum. One of the key issues in the theory of quantum programming languages is defining and understanding quantum control flow. A functional language with quantum control flow was defined by Altenkirch and Grattage [\\textit{Proc. LICS'05}, pp. 249-258]. This paper extends their work, and we introduce a general quantum control structure by defining three new quantu...

  16. The crucial role of PpMYB10.1 in anthocyanin accumulation in peach and relationships between its allelic type and skin color phenotype.

    Science.gov (United States)

    Tuan, Pham Anh; Bai, Songling; Yaegaki, Hideaki; Tamura, Takayuki; Hihara, Seisuke; Moriguchi, Takaya; Oda, Kenji

    2015-11-18

    Red coloration of fruit skin is one of the most important traits in peach (Prunus persica), and it is mainly due to the accumulation of anthocyanins. Three MYB10 genes, PpMYB10.1, PpMYB10.2, and PpMYB10.3, have been reported as important regulators of red coloration and anthocyanin biosynthesis in peach fruit. In this study, contribution of PpMYB10.1/2/3 to anthocyanin accumulation in the fruit skin was investigated in the Japanese peach cultivars, white-skinned 'Mochizuki' and red-skinned 'Akatsuki'. We then investigated the relationships between allelic type of PpMYB10.1 and skin color phenotype in 23 Japanese peach cultivars for future establishment of DNA-marker. During the fruit development of 'Mochizuki' and 'Akatsuki', anthocyanin accumulation was observed only in the skin of red 'Akatsuki' fruit in the late ripening stages concomitant with high mRNA levels of the last step gene leading to anthocyanin accumulation, UDP-glucose:flavonoid-3-O-glucosyltransferase (UFGT). This was also correlated with the expression level of PpMYB10.1. Unlike PpMYB10.1, expression levels of PpMYB10.2/3 were low in the skin of both 'Mochizuki' and 'Akatsuki' throughout fruit development. Moreover, only PpMYB10.1 revealed expression levels associated with total anthocyanin accumulation in the leaves and flowers of 'Mochizuki' and 'Akatsuki'. Introduction of PpMYB10.1 into tobacco increased the expression of tobacco UFGT, resulting in higher anthocyanin accumulation and deeper red transgenic tobacco flowers; however, overexpression of PpMYB10.2/3 did not alter anthocyanin content and color of transgenic tobacco flowers when compared with wild-type flowers. Dual-luciferase assay showed that the co-infiltration of PpMYB10.1 with PpbHLH3 significantly increased the activity of PpUFGT promoter. We also found close relationships of two PpMYB10.1 allelic types, MYB10.1-1/MYB10.1-2, with the intensity of red skin coloration. We showed that PpMYB10.1 is a major regulator of anthocyanin

  17. Penerapan Sistem Akuntansi Instansi Berbasis Akrual Sebagai Implementasi PP No. 71 Tahun 2010 pada Politeknik Negeri Pontianak

    Directory of Open Access Journals (Sweden)

    Sari Zawitri

    2015-04-01

    Full Text Available The government regulation (PP number 71 year 2010 is a new regulation standard of accounting in the public sector. The new regulation standard that inspiring the writers to the research title: Penerapan Sistem Akuntansi Instansi Berbasis Akrual sebagai Implementasi PP nomor 71 tahun 2010 pada Politeknik Negeri Pontianak. The Problems are formulated as (1 The changes of institutional accounting system (SAI PP 24 year 2005 into PP 71 year 2010 or cash toward accrual into accrual basis? (2 How preparation and the application transition accrual basis institutional accounting system (SAI or implementation PP 71 year 2010 of the Politeknik Negeri Pontianak? It’s concern to disclosure and measurement of Asset, Liabilities, Earned, and Expense. This the exploratory research method which is narrative and descriptive approach with the Politeknik Negeri Pontianak is an object. The results, as form of adjustment in order to change cash toward accrual into accrual basis, accrual accounting recognizes revenues by treasurer expenditure with adding income that still must be accepted in the accounting period during which the service is performed and/or adding unearned revenue. Politeknik Negeri Pontianak almost meets the six conditions that must have preparation and the application transition cash toward accrual into accrual basis of institutional accounting system as implementation PP 71 year 2010 be general conclusion of this research. Writers suggested all parties related in an accounting system institutional of Politeknik Negeri Pontianak commitment to keeping together in the process of financial reporting with accrual basis.

  18. A high-fructose diet induces changes in pp185 phosphorylation in muscle and liver of rats

    Directory of Open Access Journals (Sweden)

    M. Ueno

    2000-12-01

    Full Text Available Insulin stimulates the tyrosine kinase activity of its receptor resulting in the tyrosine phosphorylation of pp185, which contains insulin receptor substrates IRS-1 and IRS-2. These early steps in insulin action are essential for the metabolic effects of insulin. Feeding animals a high-fructose diet results in insulin resistance. However, the exact molecular mechanism underlying this effect is unknown. In the present study, we determined the levels and phosphorylation status of the insulin receptor and pp185 (IRS-1/2 in liver and muscle of rats submitted to a high-fructose diet evaluated by immunoblotting with specific antibodies. Feeding fructose (28 days induced a discrete insulin resistance, as demonstrated by the insulin tolerance test. Plasma glucose and serum insulin and cholesterol levels of the two groups of rats, fructose-fed and control, were similar, whereas plasma triacylglycerol concentration was significantly increased in the rats submitted to the fructose diet (P<0.05. There were no changes in insulin receptor concentration in the liver or muscle of either group. However, insulin-stimulated receptor autophosphorylation was reduced to 72 ± 4% (P<0.05 in the liver of high-fructose rats. The IRS-1 protein levels were similar in both liver and muscle of the two groups of rats. In contrast, there was a significant decrease in insulin-induced pp185 (IRS-1/2 phosphorylation, to 83 ± 5% (P<0.05 in liver and to 77 ± 4% (P<0.05 in muscle of the high-fructose rats. These data suggest that changes in the early steps of insulin signal transduction may have an important role in the insulin resistance induced by high-fructose feeding.

  19. TaPP2C1, a Group F2 Protein Phosphatase 2C Gene, Confers Resistance to Salt Stress in Transgenic Tobacco.

    Directory of Open Access Journals (Sweden)

    Wei Hu

    Full Text Available Group A protein phosphatases 2Cs (PP2Cs are essential components of abscisic acid (ABA signaling in Arabidopsis; however, the function of group F2 subfamily PP2Cs is currently less known. In this study, TaPP2C1 which belongs to group F2 was isolated and characterized from wheat. Expression of the TaPP2C1-GFP fusion protein suggested its ubiquitous localization within a cell. TaPP2C1 expression was downregulated by abscisic acid (ABA and NaCl treatments, but upregulated by H2O2 treatment. Overexpression of TaPP2C1 in tobacco resulted in reduced ABA sensitivity and increased salt resistance of transgenic seedlings. Additionally, physiological analyses showed that improved resistance to salt stress conferred by TaPP2C1 is due to the reduced reactive oxygen species (ROS accumulation, the improved antioxidant system, and the increased transcription of genes in the ABA-independent pathway. Finally, transgenic tobacco showed increased resistance to oxidative stress by maintaining a more effective antioxidant system. Taken together, these results demonstrated that TaPP2C1 negatively regulates ABA signaling, but positively regulates salt resistance. TaPP2C1 confers salt resistance through activating the antioxidant system and ABA-independent gene transcription process.

  20. Two-particle correlations in pp collisions at 13 TeV measured with CMS

    CERN Document Server

    AUTHOR|(CDS)2079326

    2016-01-01

    Results on two-particle angular correlations for charged particles emitted in $pp$ collisions at a center-of-mass energy of 13 TeV are presented as a function of charged-particle multiplicity and transverse momentum $(p_{T})$. In high$-$multiplicity events, a long-range $(\\mid \\eta \\mid> 2.0)$, near-side $(\\Delta \\phi = 0)$ structure emerges in the two-particle $\\Delta\\eta - \\Delta\\phi $ correlation functions. The overall correlation strength is similar to that found in earlier $pp$ data at 7 TeV, but is measured up to much higher multiplicity values. A detailed study in $pp$ collisions at 7 TeV of the second-order $(v_{2})$ % and third-order $(v_{3})$ azimuthal anisotropy harmonics of charged particles, $K_{S}^{0}$ and $\\Lambda/\\bar{\\Lambda}$ particles are extracted from long-range two-particle correlations as a function of particle multiplicity and transverse momentum and are also compared with values obtained in pPb and PbPb collisions at similar multiplicities.

  1. Deletion of an Endoplasmic Reticulum Stress Response Element in a ZmPP2C-A Gene Facilitates Drought Tolerance of Maize Seedlings.

    Science.gov (United States)

    Xiang, Yanli; Sun, Xiaopeng; Gao, Shan; Qin, Feng; Dai, Mingqiu

    2017-03-06

    Drought is a major abiotic stress that causes the yearly yield loss of maize, a crop cultured worldwide. Breeding drought-tolerant maize cultivars is a priority requirement of world agriculture. Clade A PP2C phosphatases (PP2C-A), which are conserved in most plant species, play important roles in abscisic acid (ABA) signaling and plant drought response. However, natural variations of PP2C-A genes that are directly associated with drought tolerance remain to be elucidated. Here, we conducted a candidate gene association analysis of the ZmPP2C-A gene family in a maize panel consisting of 368 varieties collected worldwide, and identified a drought responsive gene ZmPP2C-A10 that is tightly associated with drought tolerance. We found that the degree of drought tolerance of maize cultivars negatively correlates with the expression levels of ZmPP2C-A10. ZmPP2C-A10, like its Arabidopsis orthologs, interacts with ZmPYL ABA receptors and ZmSnRK2 kinases, suggesting that ZmPP2C-A10 is involved in mediating ABA signaling in maize. Transgenic studies in maize and Arabidopsis confirmed that ZmPP2C-A10 functions as a negative regulator of drought tolerance. Further, a causal natural variation, deletion allele-338, which bears a deletion of ERSE (endoplasmic reticulum stress response element) in the 5'-UTR region of ZmPP2C-A10, was detected. This deletion causes the loss of endoplasmic reticulum (ER) stress-induced expression of ZmPP2C-A10, leading to increased plant drought tolerance. Our study provides direct evidence linking ER stress signaling with drought tolerance and genetic resources that can be used directly in breeding drought-tolerant maize cultivars. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. Ridge formation induced by jets in pp collisions at 7 TeV

    International Nuclear Information System (INIS)

    Hwa, Rudolph C.; Yang, C. B.

    2011-01-01

    An interpretation of the ridge phenomenon found in pp collisions at 7 TeV is given in terms of enhancement of soft partons due to energy loss of semihard jets. A description of ridge formation in nuclear collisions can directly be extended to pp collisions since hydrodynamics is not used and azimuthal anisotropy is generated by semihard scattering. The observed ridge structure is then understood as a manifestation of soft-soft transverse correlation induced by semihard partons without long-range longitudinal correlation. Both the p T and multiplicity dependencies are well reproduced. Some predictions are made about other observables.

  3. Forward-Backward Asymmetry in Top-Quark Production in pp Collisions at √(s)=1.96 TeV

    International Nuclear Information System (INIS)

    Aaltonen, T.; Maki, T.; Mehtala, P.; Orava, R.; Osterberg, K.; Saarikko, H.; Remortel, N. van; Adelman, J.; Brubaker, E.; Fedorko, W. T.; Grosso-Pilcher, C.; Kim, Y. K.; Krop, D.; Kwang, S.; Paramonov, A. A.; Schmidt, M. A.; Shiraishi, S.; Shochet, M.; Wolfe, C.; Yang, U. K.

    2008-01-01

    We present measurements of the forward-backward charge asymmetry in top pair production using 1.9 fb -1 of pp collisions at √(s)=1.96 TeV recorded with the Collider Detector at Fermilab II. Correcting for acceptance and measurement dilutions we obtain parton-level asymmetries of A FB pp =0.17±0.08 in the pp frame and A FB tt =0.24±0.14 in the tt frame. The values are consistent with the standard model expectation and disfavor exotic production mechanisms with significant negative values

  4. Mechanical, thermal, rheological and morphological behaviour of irradiated PP/HA composites

    International Nuclear Information System (INIS)

    Ramirez, C.; Albano, C.; Karam, A.; Dominguez, N.; Sanchez, Y.; Gonzalez, G.

    2005-01-01

    Hydroxyapatite (HA) reinforced polypropylene (PP) composites are being developed as bone graft materials. In this research, the effect of γ irradiation on mechanical, rheological, thermal and morphological behaviour of PP-HA composites was studied. The melt flow index of polymer increased markedly when it was exposed to radiation. This is indicative of chain scission reaction as the predominant process. During the tensile testing, the composites exhibited brittle behaviour, showing no fluency point. Elongation at break showed a tendency to decrease with the increase in radiation dose while stress at break did not show significant variation with radiation dose. High HA content (>20%) and radiation dose (25 kGy) had significant influence on thermal stability

  5. A PP2C-1 Allele Underlying a Quantitative Trait Locus Enhances Soybean 100-Seed Weight

    Institute of Scientific and Technical Information of China (English)

    Xiang Lu; Yong-Cai Lai; Wei-Guang Du; Wei-Qun Man; Shou-Yi Chen; Jin-Song Zhang; Qing Xiong; Tong Cheng; Qing-Tian Li; Xin-Lei Liu; Ying-Dong Bi; Wei Li; Wan-Ke Zhang; Biao Ma

    2017-01-01

    Cultivated soybeans may lose some useful genetic loci during domestication.Introgression of genes from wild soybeans could broaden the genetic background and improve soybean agronomic traits.In this study,through whole-genome sequencing of a recombinant inbred line population derived from a cross between a wild soybean ZYD7 and a cultivated soybean HN44,and mapping of quantitative trait loci for seed weight,we discovered that a phosphatase 2C-1 (PP2C-1) allele from wild soybean ZYD7 contributes to the increase in seed weight/size.PP2C-1 may achieve this function by enhancing cell size of integument and activating a subset of seed trait-related genes.We found that PP2C-1 is associated with GmBZR1,a soybean ortholog of Arabidopsis BZR1,one of key transcription factors in brassinosteroid (BR) signaling,and facilitate accumulation of dephosphorylated GmBZR1.In contrast,the PP2C-2 allele with variations of a few amino acids at the N-terminus did not exhibit this function.Moreover,we showed that GmBZR1 could promote seed weight/size in transgenic plants.Through analysis of cultivated soybean accessions,we found that 40% of the examined accessions do not have the PP2C-1 allele,suggesting that these accessions can be improved by introduction of this allele.Taken together,our study identifies an elite allele PP2C-1,which can enhance seed weight and/or size in soybean,and pinpoints that manipulation of this allele by molecular-assisted breeding may increase production in soybean and other legumes/crops.

  6. Analysing power for quasi-elastic pp scattering in carbon and for elastic pp scattering on free protons

    International Nuclear Information System (INIS)

    Bystricky, J.; Deregel, J.; Lehar, F.

    1984-01-01

    The ratio of the analysing powers for quasi-elastic pp scattering in carbon and for elastic scattering on free protons was measured from T = 0.52 to 2.8 GeV by scattering of the SATURNE II polarized proton beam on carbon and CH 2 . It was found to have a maximum at about 0.8 GeV. The energy dependence for quasi-elastic scattering on carbon had not been measured before above 1 GeV. The observed effect was not expected from simple models

  7. Strange hadron production in pp, pPb and PbPb collisions at LHC energies

    Energy Technology Data Exchange (ETDEWEB)

    Saraswat, Kapil; Singh, Venktesh [Banaras Hindu University, Department of Physics, Institute of Science, Varanasi (India); Shukla, Prashant [Bhabha Atomic Research Center, Nuclear Physics Division, Mumbai (India); Homi Bhabha National Institute, Anushakti Nagar, Mumbai (India); Kumar, Vineet [Bhabha Atomic Research Center, Nuclear Physics Division, Mumbai (India)

    2017-05-15

    We present a systematic analysis of transverse momentum (p{sub T}) spectra of the strange hadrons in different multiplicity events produced in pp collision at √(s) = 7 TeV, pPb collision at √(s{sub NN}) = 5.02 TeV and PbPb collision at √(s{sub NN}) = 2.76 TeV. Both the single and differential freeze-out scenarios of strange hadrons K{sup 0}{sub s}, Λ and Ξ{sup -} are considered while fitting using a Tsallis distribution which is modified to include transverse flow. The p{sub T} distributions of these hadrons in different systems are characterized in terms of the parameters, namely Tsallis temperature (T), power (n) and average transverse flow velocity (β). It is found that for all the systems, transverse flow increases as we move from lower to higher multiplicity events. In the case of the differential freeze-out scenario, the degree of thermalization remains similar for events of different multiplicity classes in all the three systems. The Tsallis temperature increases with the mass of the hadrons and also increases with the event multiplicity in pp and pPb system but shows little variation with the multiplicity in PbPb system. In the case of the single freeze-out scenario, the difference between small systems (pp, pPb) and PbPb system becomes more evident. The high-multiplicity PbPb events show higher degree of thermalization as compared to the events of pp and pPb systems. The trend of variation of the temperature in PbPb system with event multiplicity is opposite to what is found in the pp and pPb systems. (orig.)

  8. New CO2 adsorbent containing aminated poly(glycidyl methacrylate) grafted onto irradiated PE-PP nonwoven sheet

    Science.gov (United States)

    Mahmoud Nasef, Mohamed; Abbasi, Ali; Ting, T. M.

    2014-10-01

    A new CO2 adsorbent containing triethylamine (TEA) was prepared by radiation induced grafting of glycidyl methacrylate (GMA) onto polyethylene coated polypropylene (PE-PP) non-woven sheet followed by amination reaction. The degree of grafting (DOG%) was controlled by variation of monomer concentration and absorbed dose. The incorporation of aminated poly(GMA) was investigated by Fourier transform infrared (FTIR) and scanning electron microscope (SEM). The adsorbent with DOG of 350% and amination yield of 60% exhibited CO2 adsorption capacity of 4.52 mol/kg at ambient temperature and pressure.

  9. Comparison of charged particle multiplicity distributions in p tilde p and pp interactions and verification of the dual unitarization scheme

    International Nuclear Information System (INIS)

    Batyunya, B.V.; Boguslavsky, I.V.; Gramenitsky, I.M.

    1979-01-01

    The difference between antiproton annihilation and pp interactions has been discussed. Charged particle multiplicity distributions in anti pp-interactions at 22.4 GeV/c were used to obtain antiproton annihilation characteristics. The comparison of the topological cross section of antipp interactions with those of non-diffractive pp interactions confirms the validity of dual unitarization

  10. Evidence for two narrow pp resonances at 2020 MeV and 2200 MeV

    CERN Document Server

    Benkheiri, P; Bouquet, B; Briandet, P; D'Almagne, B; Dang-Vu, C; De Rosny, G; Eisenstein, B I; Ferrer, A; Fleury, P; Grossetête, B; Irwin, G; Jacholkowski, A; Lahellec, A; Nguyen, H; Petroff, P; Richard, F; Rivet, P; Roudeau, P; Rougé, A; Rumpf, M; Six, J; Thénard, J M; Treille, D; Volte, A; Yaffe, D; Yiou, T P; Yoshida, H

    1977-01-01

    From the study of the reaction pi /sup -/p to p/sub F/pp pi /sup -/ using a fast proton (p/sub F/) trigger device in the CERN Omega spectrometer, the authors find evidence for two narrow pp states produced mainly in association with a Delta degrees (1232) and a N degrees (1520). The statistical significance of each peak is greater than 6 standard deviations. Masses and natural widths of these resonances are respectively M/sub 1/=2020+or-3 MeV, Gamma /sub 1 /=24+or-12 MeV and M/sub 2/=2204+or-5 MeV, Gamma /sub 2/=16/sub -16 //sup +20/ MeV. The data are consistent with a small production of the narrow approximately 1935 MeV resonance already reported. Production cross sections for these new pp resonances are given. (8 refs).

  11. Mechanical and thermal properties of commercial multilayer PET/PP film irradiated with electron-beam

    International Nuclear Information System (INIS)

    Ortiz, Angel V.; Nogueira, Beatriz R.; Oliveira, Vitor M.; Moura, Esperidiana A.B.

    2009-01-01

    The effects of electron-beam irradiation on mechanical and thermal properties, for one commercial flexible food packaging multilayer structure, were studied. The laminated poly(ethylene terephthalate) (PET)/ polypropylene (PP) structure was irradiated up to 60 kGy, using a 1.5 MeV electron beam accelerator, at room temperature in the presence of air. Mechanical properties showed significant changes (p < 0.05). In addition, the DSC analysis, after treatment, showed that the fusion enthalpy and crystallinity of the PET/PP structure components presented significant changes (p < 0.05) with the electron-beam radiation doses applied. It was observed an increase in PP crystallinity while the PET crystallinity decreases. Such decrease in PET crystallinity indicates the predominance of a cross-linking process on the irradiated PET layer; responsible for the increase in some mechanical properties of the studied film. (author)

  12. Effects of layer-multiplying and interface on the content of β-transcrystallization in PP

    International Nuclear Information System (INIS)

    Lei, Fan; Li, Jiang; Guo, Shaoyun

    2015-01-01

    The alternating multilayered polypropylene (PP layer)/β-nucleating agent filled-polypropylene (β-PP layer) were prepared through layer-multiplying extrusion combined with an assembly of layer-multiplying elements (LM Es). The content of β-crystal was firstly evaluated by differential scanning calorimetry (DSC), which indicated that the relative amount of the β-crystal increased from 38.67% to 81.22% with the increase of layer numbers from 2-layer to 128-layer. It was well consistent with the results of X-ray diffraction (XRD). The morphology observation of β-crystal by polarizing microscope (POM) revealed that the closely packed nuclei in the interface could induce numerous β-transcrystallization in pure PP layer due to the confinement effect. The non-isothermal crystallization kinetic analysis via Mozhishen’s methods manifested that the crystallization rate was greatly enhanced by the augment of the layered interface

  13. Search for Exotic Processes at the CERN pp Collider

    DEFF Research Database (Denmark)

    Ansari, R.; Bagnaia, P.; Banner, M.;......Kofoed-Hansen

    1987-01-01

    The total UA2 data sample at the CERN pp̄ Collider corresponds to an integrated luminosity of 910 nb−1. Limits on various hypothetical processes, such as production of excited electrons, additional charged or neutral vector bosons, or supersymmetric particles, are presented from the analysis...

  14. Uterotrophic and Hershberger assays for endocrine disruption properties of plastic food contact materials polypropylene (PP) and polyethylene terephthalate (PET).

    Science.gov (United States)

    Chung, Bu Young; Kyung, Minji; Lim, Seong Kwang; Choi, Seul Min; Lim, Duck Soo; Kwack, Seung Jun; Kim, Hyung Sik; Lee, Byung-Mu

    2013-01-01

    Plasticizers or plastic materials such as phthalates, bisphenol-A (BPA), and styrene are widely used in the plastic industry and are suspected endocrine-disrupting chemicals (EDC). Although plastic materials such as polypropylene (PP) and polyethylene terephthalate (PET) are not EDC and are considered to be safe, their potential properties as EDC have not been fully investigated. In this study, plastic samples eluted from plastic food containers (PP or PET) were investigated in Sprague-Dawley rats using Hershberger and uterotrophic assays. In the Hershberger assay, 6-wk-old castrated male rats were orally treated for 10 consecutive days with plastic effluent at 3 different doses (5 ml/kg) or vehicle control (corn oil, 1 ml/100 g) to determine the presence of both anti-androgenic and androgenic effects. Testosterone (0.4 mg/ml/kg) was subcutaneously administered for androgenic evaluation as a positive control, whereas testosterone (0.4 mg/ml/kg) and flutamide (3 mg/kg/day) were administered to a positive control group for anti-androgenic evaluation. The presence of any anti-androgenic or androgenic activities of plastic effluent was not detected. Sex accessory tissues such as ventral prostate or seminal vesicle showed no significant differences in weight between treated and control groups. For the uterotrophic assay, immature female rats were treated with plastic effluent at three different doses (5 ml/kg), with vehicle control (corn oil, 1 ml/100 g), or with ethinyl estradiol (3 μg/kg/d) for 3 d. There were no significant differences between test and control groups in vagina or uterine weight. Data suggest that effluents from plastic food containers do not appear to produce significant adverse effects according to Hershberger and uterotrophic assays.

  15. Polypropylene (PP) based proton exchange membrane for use in fuel cell

    International Nuclear Information System (INIS)

    Zen, Heloisa Augusto

    2008-01-01

    The radiation-induced graft of styrene onto polypropylene (PP) films was carried out by simultaneous irradiation method in a cobalt-60 source. The PP films were immersed in a solution of styrene with toluene (1:1 and 4:1, v/v) under inert atmosphere and at room temperature and then submitted at 20, 40, 80 and 100 kGy. After graft reaction the films were kept at room temperature under inert atmosphere for periods of 7, 14, 21 and 28 days in order to evaluate the degree of grafting. At the end of each period the films were sulfonated to provide the hydrophilic property to PP. The degree of grafting (DOG) was gravimetric determined and the chemical changes in the grafted and sulfonated films were characterized by Infrared Spectroscopy, Thermogravimetric Analysis (TGA), Differential Scanning Calorimetry and the Ion Exchange Capacity (IEC) was calculated. The greatest DOG was obtained after 21 days of post-irradiation. By TGA the grafted films exhibited a decrease in the thermal stability, while the sulfonated exhibited an increase. By DSC was possible to verify that matrix polymeric did not suffer any drastic change in the melting temperature after grafting and sulfonation reactions. The IEC calculated shows that the new membrane developed has ionic conductivity property. (author)

  16. Signatures of collective flow in high multiplicity pp collisions

    CERN Document Server

    Kisiel, Adam

    2011-01-01

    A blast-wave parametrization, including a full set of hadronic resonances, is used to model a small system, with total particle multiplicity comparable to the one measured in the high-multiplicity pp collisions at the LHC. Calculations are preformed for three cases: with negligible, regular and strong radial flow on the blast-wave hypersurface. We investigate the effects of flow on inclusive p_T spectra as well as on 1D and 3D femtoscopic radii for pions. Special emphasis is put on the role of pions from resonance decays. In particular we show that they magnify the flow effects present in the blast-wave stage and significantly influence the shape of the correlation functions. A specific observable, the R^E_out/R^G_side ratio is proposed as a sensitive probe of the collective effects. Model results for the high multiplicity pp collisions, for scenarios with small and large radial flow are compared.

  17. Effect of Intensive Blood Pressure Control on Cardiovascular Remodeling in Hypertensive Patients with Nephrosclerosis

    Directory of Open Access Journals (Sweden)

    Otelio Randall

    2013-01-01

    Full Text Available Pulse pressure (PP, a marker of arterial system properties, has been linked to cardiovascular (CV complications. We examined (a association between unit changes of PP and (i composite CV outcomes and (ii development of left-ventricular hypertrophy (LVH and (b effect of mean arterial pressure (MAP control on rate of change in PP. We studied 1094 nondiabetics with nephrosclerosis in the African American Study of Kidney Disease and Hypertension. Subjects were randomly assigned to usual MAP goal (102–107 mmHg or a lower MAP goal (≤92 mmHg and randomized to beta-blocker, angiotensin converting enzyme inhibitor, or calcium channel blocker. After covariate adjustment, a higher PP was associated with increased risk of CV outcome (RR = 1.28, CI = 1.11–1.47, P<0.01 and new LVH (RR = 1.26, CI = 1.04–1.54, P=0.02. PP increased at a greater rate in the usual than in lower MAP groups (slope ± SE: 1.08 ± 0.15 versus 0.42 ± 0.15 mmHg/year, P=0.002, but not by the antihypertensive treatment assignment. Observations indicate that control to a lower MAP slows the progression of PP, a correlate of cardiovascular remodeling and complications, and may be beneficial to CV health.

  18. The GODAE High Resolution Sea Surface Temperature Pilot Project (GHRSST-PP)

    Science.gov (United States)

    Donlon, C.; Ghrsst-Pp Science Team

    2003-04-01

    This paper summarises Development and Implementation Plan of the GODAE High Resolution Sea Surface Temperature Pilot Project (GHRSST-PP). The aim of the GHRSST-PP is to coordinate a new generation of global, multi-sensor, high-resolution (better than 10 km and 12 hours) SST products for the benefit of the operational and scientific community and for those with a potential interest in the products of GODAE. The GHRSST-PP project will deliver a demonstration system that integrates data from existing international satellite and in situ data sources using state-of-the-art communications and analysis tools. Primary GHRSST-PP products will be generated by fusing infrared and microwave satellite data obtained from sensors in near polar, geostationary and low earth orbits, constrained by in situ observations. Surface skin SST, sub-surface SST and SST at depth will be produced as both merged and analysed data products. Merged data products have a common grid but all input data retaining their error statistics whereas analysed data products use all data to derive a best estimate data source having one set of error statistics. Merged SST fields will not be interpolated thereby preserving the integrity of the source data as much as possible. Products will be first produced and validated using in situ observations for regional areas by regional data assembly centres (RDAC) and sent to a global data analysis centre (GDAC) for integration with other data to provide global coverage. GDAC and RDAC will be connected together with other data using a virtual dynamic distributed database (DDD). The GDAC will merge and analyse RDAC data together with other data (from the GTS and space agencies) to provide global coverage every 12 hours in real time. In all cases data products will be accurate to better than 0.5 K validated using data collected at globally distributed diagnostic data set (DDS) sites. A user information service (UIS) will work together with user applications and services

  19. Role of carbon nanotubes (CNTs) in improving wear properties of polypropylene (PP) in dry sliding condition

    International Nuclear Information System (INIS)

    Ashok Gandhi, R.; Palanikumar, K.; Ragunath, B.K.; Paulo Davim, J.

    2013-01-01

    Highlights: ► Role of carbon nanotubes (CNTs) on wear behaviour of polypropylene (PP) is evaluated. ► Effect of applied pressure and composition against a steel counter face is investigated. ► Microstructure and worn surfaces of samples are observed by scanning electron microscope. ► The wear phenomenon has been discussed based on wear losses and worn surfaces. ► The coefficient of friction (μ) and sliding time for PP and PP/CNT blend is investigated. - Abstract: Polymers are widely used for sliding couples against metals and other materials. Polypropylene is a polymer used in variety of applications includes packaging, laboratory equipments, automotive components, etc. Polypropylene is often desirable automotive material due to its low cost, colorability, chemical resistance and UV stability. In addition the range of potential polypropylene uses is nearly unlimited through the use of modifiers, additives and fillers. In the present work, the sliding wear of polypropylene (PP) and carbon nanotube (CNT) blends are evaluated as a function of applied load and composition against a steel counter face in dry condition. The addition of CNT in PP in wear performance is investigated and presented in detail. Microstructure and worn surfaces of samples were observed by scanning electron microscope. The wear phenomenon has been discussed based on wear losses and worn surfaces

  20. Measurement of long-range correlations in pp collisions characterized by presence of a Z boson with the ATLAS detector

    CERN Document Server

    Cole, Brian; The ATLAS collaboration

    2018-01-01

    Recent measurements of correlations between two particles separated in pseudorapidity and azimuthal angles have shown striking similarities between results obtained in pp, p+A and A+A collision systems. In the pp collision system, unlike in p+A and A+A collisions, the strength of the correlations, quantified by the anisotropy parameter v2, shows little dependence on the observed charged-particle multiplicity. Recent theoretical models suggest that this can result from an intrinsically weak correlation between the charged-particle multiplicity and the impact parameter of the pp collision. An independent handle on the impact parameter can be obtained in principle by requiring the presence of a hard-scattering process in the collision. This talk presents the first measurement of two-particle correlations in pp collisions with a presence of Z boson identified via its μμ decay channel. The analysis uses ATLAS data recorded with nominal pp luminosity with high pileup. A new procedure is used to correct for the co...

  1. Energy dependence of opaqueness for pp collisions at high energies

    CERN Document Server

    Chou, T T

    1978-01-01

    Opaqueness of pp collisions is evaluated at three CERN-ISR energies. Comparisons with predictions of the factorisable eikonal models and the scaling hypothesis are made. It appears that results are in favour of the factorisable models. (20 refs).

  2. Jet Fragmentation in p+p, p+Pb and Pb+Pb at ATLAS

    CERN Document Server

    Slovak, Radim; The ATLAS collaboration

    2017-01-01

    Jets are an important tool to study the hot, dense matter produced in Pb+Pb collisions at the LHC. Due to the loss of some of the jet’s energy outside the jet cone, jet rates have been found to be reduced by approximately a factor of two, in the most central events and over a wide kinematic range. In order to understand precisely how the jets are modified, it is important to measure how the jet momentum is carried by its fragmentation products. The longitudinal momentum fraction of charged particles in jets from Pb+Pb, p+Pb, and p+p collisions have been measured using the ATLAS detector. Proton-proton and p+Pb collisions provide necessary baseline measurements for quantifying the modifications in Pb+Pb collisions. In Run 1, ATLAS collected samples of p+p and Pb+Pb collisions at a center of mass energy of 2.76 TeV and a sample of p+Pb collisions at 5.02 TeV. In Run 2, large samples of p+p and Pb+Pb collisions at 5.02 TeV have been collected providing a complete set of collision systems at 5.02 TeV. In this t...

  3. Band 3 tyrosine kinase in avian erythrocyte plasma membrane is immunologically related to pp60c-src

    International Nuclear Information System (INIS)

    Hillsgrove, D.; Shores, C.G.; Parker, J.C.; Maness, P.F.

    1987-01-01

    The authors have identified in the plasma membrane of the chicken erythrocyte a 60-kDa tyrosine-specific protein kinase immunologically related to the transforming protein pp60 v-src of Rous sarcoma virus. The erythrocyte protein kinase phosphorylated heavy chains of tumor-bearing rabbit (TBR) antibodies reactive with pp60 c-src at tyrosine in immune complex protein kinase assays. The kinase was identified as a 60-kDa protein by [ 35 S]methionine labeling of erythrocytes and by autophosphorylation in immune complexes. The kinase migrated on two-dimensional gel electrophoresis with an apparent pI and molecular mass similar to pp60 c-src . A plasma membrane-enriched fraction isolated from chicken red cells contained the majority of the kinase activity. Incubation of the plasma membrane fraction with [ 32 P]ATP resulted in tyrosine phosphorylation of the anion transport protein band 3. Band 3 phosphorylation was blocked by TBR antibodies, indicting that the kinase recognized by pp60 c-src antibodies was responsible for band 3 phosphorylation. These results demonstrate that the avian erythrocyte plasma membrane contains a tightly bound tyrosine-specific protein kinase identical or closely related to pp60 c-src and that this kinase is responsible for band 3 phosphorylation in vitro

  4. Structure and function of the PP2A-shugoshin interaction

    Czech Academy of Sciences Publication Activity Database

    Xu, Z.; Cetin, B.; Anger, Martin; Cho, U. S.; Helmhart, W.; Nasmyth, K.; Xu, W.

    2009-01-01

    Roč. 35, č. 4 (2009), s. 426-441 ISSN 1097-2765 Institutional research plan: CEZ:AV0Z50450515 Keywords : oocytes * PP2A-Shugoshin * mitosis Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 14.608, year: 2009

  5. Role of current algebra in B→pp-barπ(π)

    International Nuclear Information System (INIS)

    Paver, N.; Riazuddin.

    1987-11-01

    We estimate in a current algebra framework the hadronic matrix elements relevant to the weak B→pp-barπ(π) transitions measured recently. The results so obtained are in agreement with the observed values. (author). 11 refs, 1 fig

  6. Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex.

    Science.gov (United States)

    Hiraga, Shin-Ichiro; Alvino, Gina M; Chang, Fujung; Lian, Hui-Yong; Sridhar, Akila; Kubota, Takashi; Brewer, Bonita J; Weinreich, Michael; Raghuraman, M K; Donaldson, Anne D

    2014-02-15

    Initiation of eukaryotic DNA replication requires phosphorylation of the MCM complex by Dbf4-dependent kinase (DDK), composed of Cdc7 kinase and its activator, Dbf4. We report here that budding yeast Rif1 (Rap1-interacting factor 1) controls DNA replication genome-wide and describe how Rif1 opposes DDK function by directing Protein Phosphatase 1 (PP1)-mediated dephosphorylation of the MCM complex. Deleting RIF1 partially compensates for the limited DDK activity in a cdc7-1 mutant strain by allowing increased, premature phosphorylation of Mcm4. PP1 interaction motifs within the Rif1 N-terminal domain are critical for its repressive effect on replication. We confirm that Rif1 interacts with PP1 and that PP1 prevents premature Mcm4 phosphorylation. Remarkably, our results suggest that replication repression by Rif1 is itself also DDK-regulated through phosphorylation near the PP1-interacting motifs. Based on our findings, we propose that Rif1 is a novel PP1 substrate targeting subunit that counteracts DDK-mediated phosphorylation during replication. Fission yeast and mammalian Rif1 proteins have also been implicated in regulating DNA replication. Since PP1 interaction sites are evolutionarily conserved within the Rif1 sequence, it is likely that replication control by Rif1 through PP1 is a conserved mechanism.

  7. Measurements of prompt charm production cross-sections in $pp$ collisions at $\\sqrt{s}$ = 13 TeV

    CERN Document Server

    Aaij, Roel; Adeva, Bernardo; Adinolfi, Marco; Affolder, Anthony; Ajaltouni, Ziad; Akar, Simon; Albrecht, Johannes; Alessio, Federico; Alexander, Michael; Ali, Suvayu; Alkhazov, Georgy; Alvarez Cartelle, Paula; Alves Jr, Antonio Augusto; Amato, Sandra; Amerio, Silvia; Amhis, Yasmine; An, Liupan; Anderlini, Lucio; Anderson, Jonathan; Andreassi, Guido; Andreotti, Mirco; Andrews, Jason; Appleby, Robert; Aquines Gutierrez, Osvaldo; Archilli, Flavio; d'Argent, Philippe; Artamonov, Alexander; Artuso, Marina; Aslanides, Elie; Auriemma, Giulio; Baalouch, Marouen; Bachmann, Sebastian; Back, John; Badalov, Alexey; Baesso, Clarissa; Baldini, Wander; Barlow, Roger; Barschel, Colin; Barsuk, Sergey; Barter, William; Batozskaya, Varvara; Battista, Vincenzo; Bay, Aurelio; Beaucourt, Leo; Beddow, John; Bedeschi, Franco; Bediaga, Ignacio; Bel, Lennaert; Bellee, Violaine; Belloli, Nicoletta; Belyaev, Ivan; Ben-Haim, Eli; Bencivenni, Giovanni; Benson, Sean; Benton, Jack; Berezhnoy, Alexander; Bernet, Roland; Bertolin, Alessandro; Bettler, Marc-Olivier; van Beuzekom, Martinus; Bien, Alexander; Bifani, Simone; Billoir, Pierre; Bird, Thomas; Birnkraut, Alex; Bizzeti, Andrea; Blake, Thomas; Blanc, Frédéric; Blouw, Johan; Blusk, Steven; Bocci, Valerio; Bondar, Alexander; Bondar, Nikolay; Bonivento, Walter; Borghi, Silvia; Borsato, Martino; Bowcock, Themistocles; Bowen, Espen Eie; Bozzi, Concezio; Braun, Svende; Britsch, Markward; Britton, Thomas; Brodzicka, Jolanta; Brook, Nicholas; Buchanan, Emma; Burr, Christopher; Bursche, Albert; Buytaert, Jan; Cadeddu, Sandro; Calabrese, Roberto; Calvi, Marta; Calvo Gomez, Miriam; Campana, Pierluigi; Campora Perez, Daniel; Capriotti, Lorenzo; Carbone, Angelo; Carboni, Giovanni; Cardinale, Roberta; Cardini, Alessandro; Carniti, Paolo; Carson, Laurence; Carvalho Akiba, Kazuyoshi; Casse, Gianluigi; Cassina, Lorenzo; Castillo Garcia, Lucia; Cattaneo, Marco; Cauet, Christophe; Cavallero, Giovanni; Cenci, Riccardo; Charles, Matthew; Charpentier, Philippe; Chefdeville, Maximilien; 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Zhokhov, Anatoly; Zhong, Liang; Zucchelli, Stefano

    2016-03-22

    Production cross-sections of prompt charm mesons are measured with the first data from $pp$ collisions at the LHC at a centre-of-mass energy of $13\\,\\mathrm{TeV}$. The data sample corresponds to an integrated luminosity of $4.98 \\pm 0.19\\,\\mathrm{pb}^{-1}$ collected by the LHCb experiment. The production cross-sections of $D^{0}$, $D^{+}$, $D_{s}^{+}$, and $D^{*+}$ mesons are measured in bins of charm meson transverse momentum, $p_{\\mathrm{T}}$, and rapidity, $y$, and cover the range $0 < p_{\\mathrm{T}} < 15\\,\\mathrm{GeV}/c$ and $2.0 < y < 4.5$. The inclusive cross-sections for the four mesons, including charge conjugation, within the range of $1 < p_{\\mathrm{T}} < 8\\,\\mathrm{GeV}/c$ are found to be \\begin{align*} \\begin{array}{lcr} \\sigma(pp \\to D^{0} X) &=& 2460 \\pm \\phantom{1}3 \\pm 130\\,\\mu\\mathrm{b} \\\\ \\sigma(pp \\to D^{+} X) &=& 1000 \\pm \\phantom{1}3 \\pm 110\\,\\mu\\mathrm{b} \\\\ \\sigma(pp \\to D_{s}^{+} X) &=& 460 \\pm 13 \\pm 100\\,\\mu\\ma...

  8. Influence of porous PTFE/LDPE/PP composite electret in skin ultrastructure

    International Nuclear Information System (INIS)

    Jiang, J; Liang, Y Y; Tang, Y; Ye, X T; Yang, Y J; Song, M H; Cui, L L; Hou, X M

    2008-01-01

    Corona charging and heat melting method were used to prepare porous PTFE electret and porous PTFE/LDPE/PP composite electret, respectively. After 0.5, 1, 1.5, 3 and 4 hour's action of fluorescein sodium (FINa) and -300V porous PTFE/LDPE/PP composite electret on the excised abdominal skin of rat, the skin structure was studied by means of scanning electron microscopy, transmission electron microscopy and confocal laser scanning microscopy, respectively, to probe the mechanism of electret on transdermal drug delivery. The results indicated that negative electret could increase the transdermal delivery of FINa due to its effect on changing the organized structure of stratum corneum, enlarging the hair follicles, which may be the mechanism of electret in enhancing transdermal drug delivery.

  9. Report and analysis on 'PR and PP evaluation. Example sodium fast reactor full system case study'

    International Nuclear Information System (INIS)

    Sagara, Hiroshi; Inoue, Naoko; Kawakubo, Yoko; Watahiki, Masaru

    2011-01-01

    The Generation IV (GEN IV) Nuclear Energy Systems International Forum (GIF) Proliferation Resistance and Physical Protection Working Group (PRPP WG) was established in December 2002 in order to develop the PR and valuation methodology for GEN IV nuclear energy systems. In the final report of 'PR and PP Evaluation: Example Sodium Fast Reactor (ESFR) Full System Case Study,' issued in October 2009, the demonstration study of PR and PP evaluation with the qualitative approach are summarized using ESFR with four scenario threats. The present paper reviews and analyzes some results of the ESFR case study, and identifies the challenges and direction for the PR and PP evaluation methodology with quantitative approach. (author)

  10. The Fermilab anti pp collider

    International Nuclear Information System (INIS)

    Harrison, M.

    1984-01-01

    The goal of the Tevatron I project is to achieve anti pp collisions in the centre-of-mass energy range up to 2 TeV with a luminosity of at least 10 30 cm -2 sec -1 . The project involves adapting the Tevatron to function as a storage ring and modifying the lattice to provide low-beta interaction points; changes to the Main Ring to allow anti p transfers and the installation of experimental equipment; and the construction of a anti p source. Major experimental areas will be located in the socalled BO and DO straight sections together with smaller, more specialized experiments in several of the other interacting regions. (orig./HSI)

  11. Cardiac parasympathetic outflow during dynamic exercise in humans estimated from power spectral analysis of P-P interval variability.

    Science.gov (United States)

    Takahashi, Makoto; Nakamoto, Tomoko; Matsukawa, Kanji; Ishii, Kei; Watanabe, Tae; Sekikawa, Kiyokazu; Hamada, Hironobu

    2016-03-01

    What is the central question of this study? Should we use the high-frequency (HF) component of P-P interval as an index of cardiac parasympathetic nerve activity during moderate exercise? What is the main finding and its importance? The HF component of P-P interval variability remained even at a heart rate of 120-140 beats min(-1) and was further reduced by atropine, indicating incomplete cardiac vagal withdrawal during moderate exercise. The HF component of R-R interval is invalid as an estimate of cardiac parasympathetic outflow during moderate exercise; instead, the HF component of P-P interval variability should be used. The high-frequency (HF) component of R-R interval variability has been widely used as an indirect estimate of cardiac parasympathetic (vagal) outflow to the sino-atrial node of the heart. However, we have recently found that the variability of the R-R interval becomes much smaller during dynamic exercise than that of the P-P interval above a heart rate (HR) of ∼100 beats min(-1). We hypothesized that cardiac parasympathetic outflow during dynamic exercise with a higher intensity may be better estimated using the HF component of P-P interval variability. To test this hypothesis, the HF components of both P-P and R-R interval variability were analysed using a Wavelet transform during dynamic exercise. Twelve subjects performed ergometer exercise to increase HR from the baseline of 69 ± 3 beats min(-1) to three different levels of 100, 120 and 140 beats min(-1). We also examined the effect of atropine sulfate on the HF components in eight of the 12 subjects during exercise at an HR of 140 beats min(-1) . The HF component of P-P interval variability was significantly greater than that of R-R interval variability during exercise, especially at the HRs of 120 and 140 beats min(-1). The HF component of P-P interval variability was more reduced by atropine than that of R-R interval variability. We conclude that cardiac parasympathetic outflow to the

  12. The architecture and ppGpp-dependent expression of the primary transcriptome of Salmonella Typhimurium during invasion gene expression

    Directory of Open Access Journals (Sweden)

    Ramachandran Vinoy K

    2012-01-01

    Full Text Available Abstract Background Invasion of intestinal epithelial cells by Salmonella enterica serovar Typhimurium (S. Typhimurium requires expression of the extracellular virulence gene expression programme (STEX, activation of which is dependent on the signalling molecule guanosine tetraphosphate (ppGpp. Recently, next-generation transcriptomics (RNA-seq has revealed the unexpected complexity of bacterial transcriptomes and in this report we use differential RNA sequencing (dRNA-seq to define the high-resolution transcriptomic architecture of wild-type S. Typhimurium and a ppGpp null strain under growth conditions which model STEX. In doing so we show that ppGpp plays a much wider role in regulating the S. Typhimurium STEX primary transcriptome than previously recognised. Results Here we report the precise mapping of transcriptional start sites (TSSs for 78% of the S. Typhimurium open reading frames (ORFs. The TSS mapping enabled a genome-wide promoter analysis resulting in the prediction of 169 alternative sigma factor binding sites, and the prediction of the structure of 625 operons. We also report the discovery of 55 new candidate small RNAs (sRNAs and 302 candidate antisense RNAs (asRNAs. We discovered 32 ppGpp-dependent alternative TSSs and determined the extent and level of ppGpp-dependent coding and non-coding transcription. We found that 34% and 20% of coding and non-coding RNA transcription respectively was ppGpp-dependent under these growth conditions, adding a further dimension to the role of this remarkable small regulatory molecule in enabling rapid adaptation to the infective environment. Conclusions The transcriptional architecture of S. Typhimurium and finer definition of the key role ppGpp plays in regulating Salmonella coding and non-coding transcription should promote the understanding of gene regulation in this important food borne pathogen and act as a resource for future research.

  13. Bovine pancreatic polypeptide (bPP) undergoes significant changes in conformation and dynamics upon binding to DPC micelles.

    Science.gov (United States)

    Lerch, Mirjam; Gafner, Verena; Bader, Reto; Christen, Barbara; Folkers, Gerd; Zerbe, Oliver

    2002-10-04

    The pancreatic polypeptide (PP), a 36-residue, C-terminally amidated polypeptide hormone is a member of the neuropeptide Y (NPY) family. Here, we have studied the structure and dynamics of bovine pancreatic polypeptide (bPP) when bound to DPC-micelles as a membrane-mimicking model as well as the dynamics of bPP in solution. The comparison of structure and dynamics of bPP in both states reveals remarkable differences. The overall correlation time of 5.08ns derived from the 15N relaxation data proves unambiguously that bPP in solution exists as a dimer. Therein, intermolecular as well as intramolecular hydrophobic interactions from residues of both the amphiphilic helix and of the back-folded N terminus contribute to the stability of the PP fold. The overall rigidity is well-reflected in positive values for the heteronuclear NOE for residues 4-34. The membrane-bound species displays a partitioning into a more flexible N-terminal region and a well-defined alpha-helical region comprising residues 17-31. The average RMSD value for residues 17-31 is 0.22(+/-0.09)A. The flexibility of the N terminus is compatible with negative values of the heteronuclear NOE observed for the N-terminal residues 4-12 and low values of the generalized order parameter S(2). The membrane-peptide interface was investigated by micelle-integrating spin-labels and H,2H exchange measurements. It is formed by those residues which make contacts between the C-terminal alpha-helix and the polyproline helix. In contrast to pNPY, also residues from the N terminus display spatial proximity to the membrane interface. Furthermore, the orientation of the C terminus, that presumably contains residues involved in receptor binding, is different in the two environments. We speculate that this pre-positioning of residues could be an important requirement for receptor activation. Moreover, we doubt that the PP fold is of functional relevance for binding at the Y(4) receptor.

  14. The targeting expression of the vascular endothelial growth factor gene in endothelial cells regulated by HRE.ppET-1.

    Science.gov (United States)

    Zheng, Xiangrong; Zhang, Shangshang; Yang, Yujia; Wang, Xia; Zhong, Le; Yu, Xiaohe

    2008-11-01

    The success of gene therapy depends largely on the efficacy of gene delivery vector systems that can deliver genes to target organs or cells selectively and efficiently with minimal toxicity. Here, we show that by using the HRE.ppET-1 regulatory element, we were able to restrict expression of the transgene of vascular endothelial growth factor (VEGF) to endothelial cells exclusively in hypoxic conditions. Eukaryotic expression vectors such as pEGFP-HRE.ppET-1, pcDNA3.1-VEGF+Pa, pcDNA3.1-ppET-1+ EGF+Pa, and pcDNA3.1-HRE.ppET-1+VEGF+Pa were constructed by using a series of nuclear molecule handling methods like PCR, enzyme digestion. The recombinant vectors were transfected into HUVEC cells and HL7702 cells by the lipofectin method. GFP expression was observed with a fluorescence microscope to validate the specificity of expression in endothelial cells under the regulation of HRE.ppET-1 element. Cobalt chloride (final concentration 100 mumol/L) was added to the medium to mimic hypoxia in vitro. After transfection of vectors, the expression of VEGF mRNA was detected by RT-PCR, and the expression of VEGF was detected by Western blotting and ELISA methods under normoxia and hypoxia, respectively. The cell proliferation rate was detected by the MTT test. The expression of GFP revealed that the exterior gene was transcripted effectively in endothelial cells regulated by the HRE.ppET-1 element, while the expression of GFP was very weak in nonendothelial cells. The results of RT-PCR, Western blotting and ELISA showed that VEGF gene expression in the pcDNA3.1-HRE.ppET-1+VEGF+Pa group and in the pcDNA3.1-ppET-1+VEGF+Pa group was higher in hypoxia than it was in normoxia (PHRE.ppET-1 element was expressed specifically in endothelial cells, and can increase the expression of VEGF in hypoxia and stimulate proliferation of endothelial cells. Taking advantage of these facts could greatly improve the efficiency of gene therapy. The vector would be valuable for various gene transfer

  15. W+jets in pp collisions at 7 TeV with ATLAS

    Indian Academy of Sciences (India)

    2012-10-05

    Oct 5, 2012 ... energy proton–proton (pp) environment also leads to increased contributions of qg and ... calculations in perturbative quantum chromodynamics (pQCD). ... from multiparton matrix element generators ALPGEN [11] and ...

  16. Forward-backward asymmetry in top-quark production in pp[over] collisions at sqrt[s]=1.96 TeV.

    Science.gov (United States)

    Aaltonen, T; Adelman, J; Akimoto, T; Albrow, M G; González, B Alvarez; Amerio, S; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Apollinari, G; Apresyan, A; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Aurisano, A; Azfar, F; Azzurri, P; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Bartsch, V; Bauer, G; Beauchemin, P-H; Bedeschi, F; Bednar, P; Beecher, D; Behari, S; Bellettini, G; Bellinger, J; Benjamin, D; Beretvas, A; Beringer, J; Bhatti, A; Binkley, M; Bisello, D; Bizjak, I; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bolla, G; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Bridgeman, A; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, J; Budd, H S; Budd, S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Byrum, K L; Cabrera, S; Calancha, C; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carlsmith, D; Carosi, R; Carrillo, S; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavaliere, V; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, K; Chokheli, D; Chou, J P; Choudalakis, G; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Chwalek, Th; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Compostella, G; Convery, M E; Conway, J; Copic, K; Cordelli, M; Cortiana, G; Cox, D J; Crescioli, F; Almenar, C Cuenca; Cuevas, J; Culbertson, R; Cully, J C; Dagenhart, D; Datta, M; Davies, T; de Barbaro, P; De Cecco, S; Deisher, A; De Lorenzo, G; Dell'orso, M; Deluca, C; Demortier, L; Deng, J; Deninno, M; Derwent, P F; di Giovanni, G P; Dionisi, C; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Donati, S; Dong, P; Donini, J; Dorigo, T; Dube, S; Efron, J; Elagin, A; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, W T; Feild, R G; Feindt, M; Fernandez, J P; Ferrazza, C; Field, R; Flanagan, G; Forrest, R; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; Garberson, F; Garcia, J E; Garfinkel, A F; Genser, K; Gerberich, H; Gerdes, D; Gessler, A; Giagu, S; Giakoumopoulou, V; Giannetti, P; Gibson, K; Gimmell, J L; Ginsburg, C M; Giokaris, N; Giordani, M; Giromini, P; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gresele, A; Grinstein, S; Grosso-Pilcher, C; Grundler, U; da Costa, J Guimaraes; Gunay-Unalan, Z; Haber, C; Hahn, K; Hahn, S R; Halkiadakis, E; Han, B-Y; Han, J Y; Handler, R; Happacher, F; Hara, K; Hare, D; Hare, M; Harper, S; Harr, R F; Harris, R M; Hartz, M; Hatakeyama, K; Hauser, J; Hays, C; Heck, M; Heijboer, A; Heinemann, B; Heinrich, J; Henderson, C; Herndon, M; Heuser, J; Hewamanage, S; Hidas, D; Hill, C S; Hirschbuehl, D; Hocker, A; Hou, S; Houlden, M; Hsu, S-C; Huffman, B T; Hughes, R E; Husemann, U; Huston, J; Incandela, J; Introzzi, G; Iori, M; Ivanov, A; James, E; Jayatilaka, B; Jeon, E J; Jha, M K; Jindariani, S; Johnson, W; Jones, M; Joo, K K; Jun, S Y; Jung, J E; Junk, T R; Kamon, T; Kar, D; Karchin, P E; Kato, Y; Kephart, R; Keung, J; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirsch, L; Klimenko, S; Knuteson, B; Ko, B R; Koay, S A; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kreps, M; Kroll, J; Krop, D; Krumnack, N; Kruse, M; Krutelyov, V; Kubo, T; Kuhr, T; Kulkarni, N P; Kurata, M; Kusakabe, Y; Kwang, S; Laasanen, A T; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; Lecompte, T; Lee, E; Lee, S W; Leone, S; Lewis, J D; Lin, C S; Linacre, J; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, C; Liu, T; Lockyer, N S; Loginov, A; Loreti, M; Lovas, L; Lu, R-S; Lucchesi, D; Lueck, J; Luci, C; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Lytken, E; Mack, P; Macqueen, D; Madrak, R; Maeshima, K; Makhoul, K; Maki, T; Maksimovic, P; Malde, S; Malik, S; Manca, G; Manousakis-Katsikakis, A; Margaroli, F; Marino, C; Marino, C P; Martin, A; Martin, V; Martínez, M; Martínez-Ballarín, R; Maruyama, T; Mastrandrea, P; Masubuchi, T; Mattson, M E; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Menzione, A; Merkel, P; Mesropian, C; Miao, T; Miladinovic, N; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyake, H; Moggi, N; Moon, C S; Moore, R; Morello, M J; Morlok, J; Fernandez, P Movilla; Mülmenstädt, J; Mukherjee, A; Muller, Th; Mumford, R; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Nagano, A; Naganoma, J; Nakamura, K; Nakano, I; Napier, A; Necula, V; Neu, C; Neubauer, M S; Nielsen, J; Nodulman, L; Norman, M; Norniella, O; Nurse, E; Oakes, L; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Orava, R; Osterberg, K; Griso, S Pagan; Pagliarone, C; Palencia, E; Papadimitriou, V; Papaikonomou, A; Paramonov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Peiffer, Th; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Pianori, E; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Poukhov, O; Pounder, N; Prakoshyn, F; Pronko, A; Proudfoot, J; Ptohos, F; Pueschel, E; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Reisert, B; Rekovic, V; Renton, P; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rodriguez, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Roy, P; Ruiz, A; Russ, J; Rusu, V; Saarikko, H; Safonov, A; Sakumoto, W K; Saltó, O; Santi, L; Sarkar, S; Sartori, L; Sato, K; Savoy-Navarro, A; Scheidle, T; Schlabach, P; Schmidt, A; Schmidt, E E; Schmidt, M A; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scott, A L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sfyrla, A; Shalhout, S Z; Shears, T; Shepard, P F; Sherman, D; Shimojima, M; Shiraishi, S; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Sinervo, P; Sisakyan, A; Slaughter, A J; Slaunwhite, J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Soha, A; Somalwar, S; Sorin, V; Spalding, J; Spreitzer, T; Squillacioti, P; Stanitzki, M; Denis, R St; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Stuart, D; Suh, J S; Sukhanov, A; Suslov, I; Suzuki, T; Taffard, A; Takashima, R; Takeuchi, Y; Tanaka, R; Tecchio, M; Teng, P K; Terashi, K; Thom, J; Thompson, A S; Thompson, G A; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Totaro, P; Tourneur, S; Tu, Y; Turini, N; Ukegawa, F; Vallecorsa, S; van Remortel, N; Varganov, A; Vataga, E; Vázquez, F; Velev, G; Vellidis, C; Veszpremi, V; Vidal, M; Vidal, R; Vila, I; Vilar, R; Vine, T; Vogel, M; Volobouev, I; Volpi, G; Würthwein, F; Wagner, P; Wagner, R G; Wagner, R L; Wagner-Kuhr, J; Wagner, W; Wakisaka, T; Wallny, R; Wang, S M; Warburton, A; Waters, D; Weinberger, M; Weinelt, J; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Williams, G; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Wright, T; Wu, X; Wynne, S M; Yagil, A; Yamamoto, K; Yamaoka, J; Yang, U K; Yang, Y C; Yao, W M; Yeh, G P; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanello, L; Zanetti, A; Zaw, I; Zhang, X; Zheng, Y; Zucchelli, S

    2008-11-14

    We present measurements of the forward-backward charge asymmetry in top pair production using 1.9 fb;{-1} of pp[over ] collisions at sqrt[s]=1.96 TeV recorded with the Collider Detector at Fermilab II. Correcting for acceptance and measurement dilutions we obtain parton-level asymmetries of A_{FB};{pp[over ]}=0.17+/-0.08 in the pp[over ] frame and A_{FB};{tt[over ]}=0.24+/-0.14 in the tt[over ] frame. The values are consistent with the standard model expectation and disfavor exotic production mechanisms with significant negative values.

  17. Tensor hypercontracted ppRPA: Reducing the cost of the particle-particle random phase approximation from O(r {sup 6}) to O(r {sup 4})

    Energy Technology Data Exchange (ETDEWEB)

    Shenvi, Neil; Yang, Yang; Yang, Weitao [Department of Chemistry, Duke University, Durham, NC 27708 (United States); Aggelen, Helen van [Department of Chemistry, Princeton University, Princeton, New Jersey 08544 (United States)

    2014-07-14

    In recent years, interest in the random-phase approximation (RPA) has grown rapidly. At the same time, tensor hypercontraction has emerged as an intriguing method to reduce the computational cost of electronic structure algorithms. In this paper, we combine the particle-particle random phase approximation with tensor hypercontraction to produce the tensor-hypercontracted particle-particle RPA (THC-ppRPA) algorithm. Unlike previous implementations of ppRPA which scale as O(r{sup 6}), the THC-ppRPA algorithm scales asymptotically as only O(r{sup 4}), albeit with a much larger prefactor than the traditional algorithm. We apply THC-ppRPA to several model systems and show that it yields the same results as traditional ppRPA to within mH accuracy. Our method opens the door to the development of post-Kohn Sham functionals based on ppRPA without the excessive asymptotic cost of traditional ppRPA implementations.

  18. Using anti pp annihilation to find exotic mesons

    International Nuclear Information System (INIS)

    Sharpe, S.R.

    1987-10-01

    Present data suggests that a number of mesons have been found which cannot be accommodated in standard anti qq multiplets. Theory suggests that such exotic mesons should exist in the spectrum of Quantum Chromodynamics, but provides little guide to their properties. It is argued that a high luminosity, low energy anti pp machine would be a powerful tool with which to search for such exotics

  19. LDPE and PP thermal diffusivity in molten state

    OpenAIRE

    Yánez, G.; Rodríguez - Pérez, M. A; Almanza, O. A.

    2013-01-01

    Experimental results are reported for measuring the thermal diffusivity of two polymer species: low density polyethylene (LDPE) and polypropylene (PP). Measurements were taken in unsteady state heat flow conditions around the materials' melting temperature, using a device specially constructed for this purpose. The experimental results for the sample's temperature profile (temperature gradient product) were adjusted with the theoretical results obtained by solving the heat conduction equation...

  20. Pseudodifferential Perturbations and Stabilization of Distributed Parameter Systems: Dirichlet Feedback Control Problems

    DEFF Research Database (Denmark)

    Pedersen, Michael

    1991-01-01

    The stabilization problems for parabolic and hyperbolic partial differential equations with Dirichlet boundary condition are considered. The systems are stabilized by a boundary feedback in(1) The operator equation,(2) The boundary condition,(3) Both the operator equation and the boundary condition...... turns out to be a shortcut to some of the stabilization results of Lasiecka and Triggiani in [J. Differential Equations, 47 (1983), pp. 245-272], [SIAM J. Control Optim., 21(1983), pp. 766-802], and [Appl. Math. Optim., 8(1981), pp. 1-37], and it illuminates to some extent how a change of boundary...

  1. Study of polypropylene irradiation to ensure the control of its environmental degradation

    International Nuclear Information System (INIS)

    Romano, Rebeca da Silva Grecco

    2017-01-01

    UV light, heat, and pollutants can interact with Polypropylene (PP) molecules, mainly with the tertiary carbon producing free radicals which can react with oxygen producing changes in its properties. PP has outstanding chemical and physical properties and a good processability at very low market price. In addition, PP is extensively used for manufacturing various kinds of products, however due to its large-scale consumption a lot of waste is generated at the end of their life cycle to the environment with low rate degradation. Controlled degradation of PP can be achieved by exposing the polymers to well defined parameters, such as absorbed dose, intemperies, oxygen, etc. In this study, structural changes in PP macro-molecule are created upon exposure to ionizing radiation such as: main chain scission, crosslinking and peroxidation (in presence of air). This study has the objective of comparing the environmental and accelerated exposures of PP neat, PP irradiated with 12,5 kGy and 20 kGy and the incorporation of the commercial pro-degradant d2w®. Dumbbell samples were manufactured by injection molding and exposed to the environment during 180 days and to accelerated aging to 192 days. The samples were characterized by Mechanical Testing, Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), X-ray Diffraction (DRX) and Differential Scanning Calorimetry (DSC). The samples previously irradiated, PP 20 kGy, after environmental aging showed higher oxidation and presence of surface cracks than the PP d2w® and PP neat. They also showed presence of carbonyl groups, decreases in elongation at break, increase in Strength Modulus and decrease of melting temperature corroborating with degradation. (author)

  2. Polypropylene (PP) based proton exchange membrane for use in fuel cell; Obtencao de membrana trocadora de protons para uso em celula a combustivel, a base de polipropileno (PP)

    Energy Technology Data Exchange (ETDEWEB)

    Zen, Heloisa Augusto

    2008-07-01

    The radiation-induced graft of styrene onto polypropylene (PP) films was carried out by simultaneous irradiation method in a cobalt-60 source. The PP films were immersed in a solution of styrene with toluene (1:1 and 4:1, v/v) under inert atmosphere and at room temperature and then submitted at 20, 40, 80 and 100 kGy. After graft reaction the films were kept at room temperature under inert atmosphere for periods of 7, 14, 21 and 28 days in order to evaluate the degree of grafting. At the end of each period the films were sulfonated to provide the hydrophilic property to PP. The degree of grafting (DOG) was gravimetric determined and the chemical changes in the grafted and sulfonated films were characterized by Infrared Spectroscopy, Thermogravimetric Analysis (TGA), Differential Scanning Calorimetry and the Ion Exchange Capacity (IEC) was calculated. The greatest DOG was obtained after 21 days of post-irradiation. By TGA the grafted films exhibited a decrease in the thermal stability, while the sulfonated exhibited an increase. By DSC was possible to verify that matrix polymeric did not suffer any drastic change in the melting temperature after grafting and sulfonation reactions. The IEC calculated shows that the new membrane developed has ionic conductivity property. (author)

  3. Phosphatase PP2A and microtubule-mediated pulling forces disassemble centrosomes during mitotic exit

    Directory of Open Access Journals (Sweden)

    Stephen J. Enos

    2018-01-01

    Full Text Available Centrosomes are microtubule-nucleating organelles that facilitate chromosome segregation and cell division in metazoans. Centrosomes comprise centrioles that organize a micron-scale mass of protein called pericentriolar material (PCM from which microtubules nucleate. During each cell cycle, PCM accumulates around centrioles through phosphorylation-mediated assembly of PCM scaffold proteins. During mitotic exit, PCM swiftly disassembles by an unknown mechanism. Here, we used Caenorhabditis elegans embryos to determine the mechanism and importance of PCM disassembly in dividing cells. We found that the phosphatase PP2A and its regulatory subunit SUR-6 (PP2ASUR-6, together with cortically directed microtubule pulling forces, actively disassemble PCM. In embryos depleted of these activities, ∼25% of PCM persisted from one cell cycle into the next. Purified PP2ASUR-6 could dephosphorylate the major PCM scaffold protein SPD-5 in vitro. Our data suggest that PCM disassembly occurs through a combination of dephosphorylation of PCM components and force-driven fragmentation of the PCM scaffold.

  4. Slug-tests in PP- and PVP-holes at Olkiluoto in 2008

    International Nuclear Information System (INIS)

    Keskitalo, K.

    2009-02-01

    As part of the program for the final disposal of the nuclear fuel waste, Posiva Oy investigates the hydrological conditions at the Olkiluoto island. The hydraulic conductivity in the shallow holes OL-PP36, OL-PP39, OL-PVP4A, OL-PVP4B, OL-PVP6A, OL-PVP6B, OL-PVP14, OL-PVP21, OL-PVP22, OL-PVP23, OL-PVP24, OL-PVP25, OL-PVP26, OL-PVP27, OL-PVP28, OL-PVP29, OL-HP1, OL-HP2 and OL-HP4 was measured in summer 2008. The length of PP-holes was between 12 and 14 m, and the test sections (1 m) are located in the bedrock. PVP-tubes have an average length between 3 - 11 m, and the test sections (mostly 2 m) are located in the overburden. The measurements were done using the slug-test technique. In the slug-test, the hydraulic head in the borehole is abruptly changed either by pouring water into the borehole or by lowering the pressure sensor. The hydraulic conductivity is interpreted from the recovery of the water level. This report presents the field measurements and their interpretation. The interpretation has been done using the Hvorslev's method, and for reference, conductivity has also been calculated according to Thiem's equation. According to the results, hydraulic conductivity in PP-holes ranges from 10 -9 m/s to 10 -6 m/s and in PVP-tubes from 10 -8 m/s to 10 -5 m/s. The observed range is similar as in the previous measurements in 2002 and 2004 - 2007. In general, the results are consistent with the results obtained in earlier measurements. In OL-PVP14, there seems to be a lowering trend of the conductivity. In OL-PVP4A the results seem to have slight increase year after year. Also, the results agree with hydraulic conductivity interpreted from the pre-pumping done in connection with the groundwater sampling or installation of observation tubes. (orig.)

  5. Slug-tests in PP- and PVP-holes at Olkiluoto in 2009

    International Nuclear Information System (INIS)

    Isola, O.

    2010-11-01

    As part of the program for the final disposal of the nuclear fuel waste, Posiva Oy investigates the hydrological conditions at the Olkiluoto Island. The hydraulic conductivity in the shallow holes OL-PP36, OL-PP39, OL-PVP4A, OL-PVP4B, OL-PVP6A, OL-PVP6B, OL-PVP14, OL-PVP30, OL-PVP31A, OL-PVP31B, OLPVP32, OL-PVP33, OL-PVP34A, OL-PVP34B, OL-HP1, OL-HP2, OL-HP3 and OLHP4 was measured in summer 2009. The length of PP-holes was between 12 and 14 m, and the test sections (1 m) are located in the bedrock. PVP-tubes have an average length between 3 - 11 m, and the test sections (mostly 2 m) are located in the overburden. The measurements were done using the slug-test technique. In the slug-test, the hydraulic head in the borehole is abruptly changed either by pouring water into the borehole or by lowering the pressure sensor. The hydraulic conductivity is interpreted from the recovery of the water level. This report presents the field measurements and their interpretation. The interpretation has been done using the Hvorslev's method, and for reference, conductivity has also been calculated according to Thiem's equation. According to the results, hydraulic conductivity in PP-holes ranges from 10 -1 0 m/s to 10 -6 m/s and in PVP-tubes from 10 -8 m/s to 10 -5 m/s. The observed range is quite similar as in the previous measurements in 2002 and 2004 - 2008. In general, the results are consistent with the results obtained in earlier measurements. In OL-PVP14, there seems to be a lowering trend of the conductivity. Also, the results agree relatively well with hydraulic conductivity interpreted from the pre-pumping done in connection with the groundwater sampling. (orig.)

  6. Discovering Pediatric Asthma Phenotypes on the Basis of Response to Controller Medication Using Machine Learning.

    Science.gov (United States)

    Ross, Mindy K; Yoon, Jinsung; van der Schaar, Auke; van der Schaar, Mihaela

    2018-01-01

    Pediatric asthma has variable underlying inflammation and symptom control. Approaches to addressing this heterogeneity, such as clustering methods to find phenotypes and predict outcomes, have been investigated. However, clustering based on the relationship between treatment and clinical outcome has not been performed, and machine learning approaches for long-term outcome prediction in pediatric asthma have not been studied in depth. Our objectives were to use our novel machine learning algorithm, predictor pursuit (PP), to discover pediatric asthma phenotypes on the basis of asthma control in response to controller medications, to predict longitudinal asthma control among children with asthma, and to identify features associated with asthma control within each discovered pediatric phenotype. We applied PP to the Childhood Asthma Management Program study data (n = 1,019) to discover phenotypes on the basis of asthma control between assigned controller therapy groups (budesonide vs. nedocromil). We confirmed PP's ability to discover phenotypes using the Asthma Clinical Research Network/Childhood Asthma Research and Education network data. We next predicted children's asthma control over time and compared PP's performance with that of traditional prediction methods. Last, we identified clinical features most correlated with asthma control in the discovered phenotypes. Four phenotypes were discovered in both datasets: allergic not obese (A + /O - ), obese not allergic (A - /O + ), allergic and obese (A + /O + ), and not allergic not obese (A - /O - ). Of the children with well-controlled asthma in the Childhood Asthma Management Program dataset, we found more nonobese children treated with budesonide than with nedocromil (P = 0.015) and more obese children treated with nedocromil than with budesonide (P = 0.008). Within the obese group, more A + /O + children's asthma was well controlled with nedocromil than with budesonide (P = 0.022) or with placebo

  7. Generalized parton distributions and rapidity gap survival in exclusive diffractive pp scattering

    Energy Technology Data Exchange (ETDEWEB)

    Leonid Frankfurt; Charles Hyde-Wright; Mark Strikman; Christian Weiss

    2007-03-01

    We propose a new approach to the problem of rapidity gap survival (RGS) in the production of high-mass systems (H = dijet, heavy quarkonium, Higgs boson) in double-gap exclusive diffractive pp scattering, pp-->p + (gap) + H + (gap) + p. It is based on the idea that hard and soft interactions proceed over widely different time- and distance scales and are thus approximately independent. The high-mass system is produced in a hard scattering process with exchange of two gluons between the protons. Its amplitude is calculable in terms of the gluon generalized parton distributions (GPDs) in the protons, which can be measured in J= production in exclusive ep scattering. The hard scattering process is modified by soft spectator interactions, which we calculate in a model-independent way in terms of the pp elastic scattering amplitude. Contributions from inelastic intermediate states are suppressed. A simple geometric picture of the interplay of hard and soft interactions in diffraction is obtained. The onset of the black-disk limit in pp scattering at TeV energies strongly suppresses diffraction at small impact parameters and is the main factor in determining the RGS probability. Correlations between hard and soft interactions (e.g. due to scattering from the long-range pion field of the proton, or due to possible short-range transverse correlations between partons) further decrease the RGS probability. We also investigate the dependence of the diffractive cross section on the transverse momenta of the final-state protons (''diffraction pattern''). By measuring this dependence one can perform detailed tests of the interplay of hard and soft interactions, and even extract information about the gluon GPD in the proton. Such studies appear to be feasible with the planned forward detectors at the LHC.

  8. Generalized parton distributions and rapidity gap survival in exclusive diffractive pp scattering

    International Nuclear Information System (INIS)

    Leonid Frankfurt; Charles Hyde-Wright; Mark Strikman; Christian Weiss

    2006-01-01

    We propose a new approach to the problem of rapidity gap survival (RGS) in the production of high-mass systems (H = dijet, heavy quarkonium, Higgs boson) in double-gap exclusive diffractive pp scattering, pp-->p + (gap) + H + (gap) + p. It is based on the idea that hard and soft interactions proceed over widely different time- and distance scales and are thus approximately independent. The high-mass system is produced in a hard scattering process with exchange of two gluons between the protons. Its amplitude is calculable in terms of the gluon generalized parton distributions (GPDs) in the protons, which can be measured in J= production in exclusive ep scattering. The hard scattering process is modified by soft spectator interactions, which we calculate in a model-independent way in terms of the pp elastic scattering amplitude. Contributions from inelastic intermediate states are suppressed. A simple geometric picture of the interplay of hard and soft interactions in diffraction is obtained. The onset of the black-disk limit in pp scattering at TeV energies strongly suppresses diffraction at small impact parameters and is the main factor in determining the RGS probability. Correlations between hard and soft interactions (e.g. due to scattering from the long-range pion field of the proton, or due to possible short-range transverse correlations between partons) further decrease the RGS probability. We also investigate the dependence of the diffractive cross section on the transverse momenta of the final-state protons (''diffraction pattern''). By measuring this dependence one can perform detailed tests of the interplay of hard and soft interactions, and even extract information about the gluon GPD in the proton. Such studies appear to be feasible with the planned forward detectors at the LHC

  9. High-energy pp and p-barp scattering and the model of geometric scaling

    International Nuclear Information System (INIS)

    Fischer, J.; Jakes, P.; Novak, M.

    1982-10-01

    The model of geometric scaling is used to predict the evolution of the diffractive dip-peak structure of pp and p-barp differential cross-sections with increasing energy. Previous calculation for pp scattering made by Dias de Deus and Kroll is carried out with new data and their predictions confirmed. Recent data on p-barp scattering are used to make an analogous analysis for this process as well. It turns out that the p-barp differential cross-section behaves analogously, the main difference being that, in the p-barp case, the dip-peak structure should not completely disappear with increasing energy. (author)

  10. Determination of polyparameter linear free energy relationship (pp-LFER) substance descriptors for established and alternative flame retardants.

    Science.gov (United States)

    Stenzel, Angelika; Goss, Kai-Uwe; Endo, Satoshi

    2013-02-05

    Polyparameter linear free energy relationships (pp-LFERs) can predict partition coefficients for a multitude of environmental and biological phases with high accuracy. In this work, the pp-LFER substance descriptors of 40 established and alternative flame retardants (e.g., polybrominated diphenyl ethers, hexabromocyclododecane, bromobenzenes, trialkyl phosphates) were determined experimentally. In total, 251 data for gas-chromatographic (GC) retention times and liquid/liquid partition coefficients (K) were measured and used to calibrate the pp-LFER substance descriptors. Substance descriptors were validated through a comparison between predicted and experimental log K for the systems octanol/water (K(ow)), water/air (K(wa)), organic carbon/water (K(oc)) and liposome/water (K(lipw)), revealing a high reliability of pp-LFER predictions based on our descriptors. For instance, the difference between predicted and experimental log K(ow) was <0.3 log units for 17 out of 21 compounds for which experimental values were available. Moreover, we found an indication that the H-bond acceptor value (B) depends on the solvent for some compounds. Thus, for predicting environmentally relevant partition coefficients it is important to determine B values using measurements in aqueous systems. The pp-LFER descriptors calibrated in this study can be used to predict partition coefficients for which experimental data are unavailable, and the predicted values can serve as references for further experimental measurements.

  11. In vivo wide-field multispectral dosimeter for use in ALA-PpIX based photodynamic therapy of skin

    Science.gov (United States)

    LaRochelle, Ethan P. M.; Davis, Scott C.; de Souza, Ana Luiza Ribeiro; Pogue, Brian W.

    2017-02-01

    Photodynamic therapy (PDT) for Actinic Kertoses (AK) using aminoluvelinic acid (ALA) is an FDA-approved treatment, which is generally effective, yet response rates vary. The origin of the variability is not well characterized, but may be related to inter-patient variability in the production of protoporphyrin IX (PpIX). While fiber-based point probe systems provide a method for measuring PpIX production, these measurements have demonstrated large spatial and inter-operator variability. Thus, in an effort to improve patient-specific dosimetry and treatment it is important to develop a robust system that accounts for spatial variability and reduces the chance of operator errors. To address this need, a wide-field multispectral imaging system was developed that is capable of quantifying maps of PpIX in both liquid phantoms and in vivo experiments, focusing on high sensitivity light signals. The system uses both red and blue excitation to elicit a fluorescent response at varying skin depths. A ten-position filter wheel with bandpass filters ranging from 635nm to 710nm are used to capture images along the emission band. A linear least-square spectral fitting algorithm provides the ability to decouple background autofluorescence from PpIX fluorescence, which has improved the system sensitivity by an order of magnitude, detecting nanomolar PpIX concentrations in liquid phantoms in the presence of 2% whole blood and 2% intralipid.

  12. Evidence for collectivity in pp collisions at the LHC

    CERN Document Server

    Khachatryan, Vardan; Tumasyan, Armen; Adam, Wolfgang; Aşılar, Ece; Bergauer, Thomas; Brandstetter, Johannes; Brondolin, Erica; Dragicevic, Marko; Erö, Janos; Flechl, Martin; Friedl, Markus; Fruehwirth, Rudolf; Ghete, Vasile Mihai; Hartl, Christian; Hörmann, Natascha; Hrubec, Josef; Jeitler, Manfred; König, Axel; Krätschmer, Ilse; Liko, Dietrich; Matsushita, Takashi; Mikulec, Ivan; Rabady, Dinyar; Rad, Navid; Rahbaran, Babak; Rohringer, Herbert; Schieck, Jochen; Strauss, Josef; Treberer-Treberspurg, Wolfgang; Waltenberger, Wolfgang; Wulz, Claudia-Elisabeth; Mossolov, Vladimir; Shumeiko, Nikolai; Suarez Gonzalez, Juan; Alderweireldt, Sara; De Wolf, Eddi A; Janssen, Xavier; Lauwers, Jasper; Van De Klundert, Merijn; Van Haevermaet, Hans; Van Mechelen, Pierre; Van Remortel, Nick; Van Spilbeeck, Alex; Abu Zeid, Shimaa; Blekman, Freya; D'Hondt, Jorgen; Daci, Nadir; De Bruyn, Isabelle; Deroover, Kevin; Heracleous, Natalie; Lowette, Steven; Moortgat, Seth; Moreels, Lieselotte; Olbrechts, Annik; Python, Quentin; Tavernier, Stefaan; Van Doninck, Walter; Van Mulders, Petra; Van Parijs, Isis; Brun, Hugues; Caillol, Cécile; Clerbaux, Barbara; De Lentdecker, Gilles; Delannoy, Hugo; Fasanella, Giuseppe; Favart, Laurent; Goldouzian, Reza; Grebenyuk, Anastasia; Karapostoli, Georgia; Lenzi, Thomas; Léonard, Alexandre; Luetic, Jelena; Maerschalk, Thierry; Marinov, Andrey; Randle-conde, Aidan; Seva, Tomislav; Vander Velde, Catherine; Vanlaer, Pascal; Yonamine, Ryo; Zenoni, Florian; Zhang, Fengwangdong; Cimmino, Anna; Cornelis, Tom; Dobur, Didar; Fagot, Alexis; Garcia, Guillaume; Gul, Muhammad; Poyraz, Deniz; Salva Diblen, Sinem; Schöfbeck, Robert; Sharma, Archana; Tytgat, Michael; Van Driessche, Ward; Yazgan, Efe; Zaganidis, Nicolas; Bakhshiansohi, Hamed; Beluffi, Camille; Bondu, Olivier; Brochet, Sébastien; Bruno, Giacomo; Caudron, Adrien; De Visscher, Simon; Delaere, Christophe; Delcourt, Martin; Francois, Brieuc; Giammanco, Andrea; Jafari, Abideh; Jez, Pavel; Komm, Matthias; Lemaitre, Vincent; Magitteri, Alessio; Mertens, Alexandre; Musich, Marco; Nuttens, Claude; Piotrzkowski, Krzysztof; Quertenmont, Loic; Selvaggi, Michele; Vidal Marono, Miguel; Wertz, Sébastien; Beliy, Nikita; Aldá Júnior, Walter Luiz; Alves, Fábio Lúcio; Alves, Gilvan; Brito, Lucas; Hensel, Carsten; Moraes, Arthur; Pol, Maria Elena; Rebello Teles, Patricia; Belchior Batista Das Chagas, Ewerton; Carvalho, Wagner; Chinellato, Jose; Custódio, Analu; Melo Da Costa, Eliza; Da Silveira, Gustavo Gil; De Jesus Damiao, Dilson; De Oliveira Martins, Carley; Fonseca De Souza, Sandro; Huertas Guativa, Lina Milena; Malbouisson, Helena; Matos Figueiredo, Diego; Mora Herrera, Clemencia; Mundim, Luiz; Nogima, Helio; Prado Da Silva, Wanda Lucia; Santoro, Alberto; Sznajder, Andre; Tonelli Manganote, Edmilson José; Vilela Pereira, Antonio; Ahuja, Sudha; Bernardes, Cesar Augusto; Dogra, Sunil; Tomei, Thiago; De Moraes Gregores, Eduardo; Mercadante, Pedro G; Moon, Chang-Seong; Novaes, Sergio F; Padula, Sandra; Romero Abad, David; Ruiz Vargas, José Cupertino; Aleksandrov, Aleksandar; Hadjiiska, Roumyana; Iaydjiev, Plamen; Rodozov, Mircho; Stoykova, Stefka; Sultanov, Georgi; Vutova, Mariana; Dimitrov, Anton; Glushkov, Ivan; Litov, Leander; Pavlov, Borislav; Petkov, Peicho; Fang, Wenxing; Ahmad, Muhammad; Bian, Jian-Guo; Chen, Guo-Ming; Chen, He-Sheng; Chen, Mingshui; Chen, Ye; Cheng, Tongguang; Jiang, Chun-Hua; Leggat, Duncan; Liu, Zhenan; Romeo, Francesco; Shaheen, Sarmad Masood; Spiezia, Aniello; Tao, Junquan; Wang, Chunjie; Wang, Zheng; Zhang, Huaqiao; Zhao, Jingzhou; Ban, Yong; Chen, Geng; Li, Qiang; Liu, Shuai; Mao, Yajun; Qian, Si-Jin; Wang, Dayong; Xu, Zijun; Avila, Carlos; Cabrera, Andrés; Chaparro Sierra, Luisa Fernanda; Florez, Carlos; Gomez, Juan Pablo; González Hernández, Carlos Felipe; Ruiz Alvarez, José David; Sanabria, Juan Carlos; Godinovic, Nikola; Lelas, Damir; Puljak, Ivica; Ribeiro Cipriano, Pedro M; Sculac, Toni; Antunovic, Zeljko; Kovac, Marko; Brigljevic, Vuko; Ferencek, Dinko; Kadija, Kreso; Micanovic, Sasa; Sudic, Lucija; Susa, Tatjana; Attikis, Alexandros; Mavromanolakis, Georgios; Mousa, Jehad; Nicolaou, Charalambos; Ptochos, Fotios; Razis, Panos A; Rykaczewski, Hans; Finger, Miroslav; Finger Jr, Michael; Carrera Jarrin, Edgar; Abdelalim, Ahmed Ali; El-khateeb, Esraa; Salama, Elsayed; Calpas, Betty; Kadastik, Mario; Murumaa, Marion; Perrini, Lucia; Raidal, Martti; Tiko, Andres; Veelken, Christian; Eerola, Paula; Pekkanen, Juska; Voutilainen, Mikko; Härkönen, Jaakko; Karimäki, Veikko; Kinnunen, Ritva; Lampén, Tapio; Lassila-Perini, Kati; Lehti, Sami; Lindén, Tomas; Luukka, Panja-Riina; Tuominiemi, Jorma; Tuovinen, Esa; Wendland, Lauri; Talvitie, Joonas; Tuuva, Tuure; Besancon, Marc; Couderc, Fabrice; Dejardin, Marc; Denegri, Daniel; Fabbro, Bernard; Faure, Jean-Louis; Favaro, Carlotta; Ferri, Federico; Ganjour, Serguei; Ghosh, Saranya; Givernaud, Alain; Gras, Philippe; Hamel de Monchenault, Gautier; Jarry, Patrick; Kucher, Inna; Locci, Elizabeth; Machet, Martina; Malcles, Julie; Rander, John; Rosowsky, André; Titov, Maksym; Zghiche, Amina; Abdulsalam, Abdulla; Antropov, Iurii; Baffioni, Stephanie; Beaudette, Florian; Busson, Philippe; Cadamuro, Luca; Chapon, Emilien; Charlot, Claude; Davignon, Olivier; Granier de Cassagnac, Raphael; Jo, Mihee; Lisniak, Stanislav; Miné, Philippe; Nguyen, Matthew; Ochando, Christophe; Ortona, Giacomo; Paganini, Pascal; Pigard, Philipp; Regnard, Simon; Salerno, Roberto; Sirois, Yves; Strebler, Thomas; Yilmaz, Yetkin; Zabi, Alexandre; Agram, Jean-Laurent; Andrea, Jeremy; Aubin, Alexandre; Bloch, Daniel; Brom, Jean-Marie; Buttignol, Michael; Chabert, Eric Christian; Chanon, Nicolas; Collard, Caroline; Conte, Eric; Coubez, Xavier; Fontaine, Jean-Charles; Gelé, Denis; Goerlach, Ulrich; Le Bihan, Anne-Catherine; Skovpen, Kirill; Van Hove, Pierre; Gadrat, Sébastien; Beauceron, Stephanie; Bernet, Colin; Boudoul, Gaelle; Bouvier, Elvire; Carrillo Montoya, Camilo Andres; Chierici, Roberto; Contardo, Didier; Courbon, Benoit; Depasse, Pierre; El Mamouni, Houmani; Fan, Jiawei; Fay, Jean; Gascon, Susan; Gouzevitch, Maxime; Grenier, Gérald; Ille, Bernard; Lagarde, Francois; Laktineh, Imad Baptiste; Lethuillier, Morgan; Mirabito, Laurent; Pequegnot, Anne-Laure; Perries, Stephane; Popov, Andrey; Sabes, David; Sordini, Viola; Vander Donckt, Muriel; Verdier, Patrice; Viret, Sébastien; Toriashvili, Tengizi; Tsamalaidze, Zviad; Autermann, Christian; Beranek, Sarah; Feld, Lutz; Heister, Arno; Kiesel, Maximilian Knut; Klein, Katja; Lipinski, Martin; Ostapchuk, Andrey; Preuten, Marius; Raupach, Frank; Schael, Stefan; Schomakers, Christian; Schulte, Jan-Frederik; Schulz, Johannes; Verlage, Tobias; Weber, Hendrik; Zhukov, Valery; Albert, Andreas; Brodski, Michael; Dietz-Laursonn, Erik; Duchardt, Deborah; Endres, Matthias; Erdmann, Martin; Erdweg, Sören; Esch, Thomas; Fischer, Robert; Güth, Andreas; Hamer, Matthias; Hebbeker, Thomas; Heidemann, Carsten; Hoepfner, Kerstin; Knutzen, Simon; Merschmeyer, Markus; Meyer, Arnd; Millet, Philipp; Mukherjee, Swagata; Olschewski, Mark; Padeken, Klaas; Pook, Tobias; Radziej, Markus; Reithler, Hans; Rieger, Marcel; Scheuch, Florian; Sonnenschein, Lars; Teyssier, Daniel; Thüer, Sebastian; Cherepanov, Vladimir; Flügge, Günter; Haj Ahmad, Wael; Hoehle, Felix; Kargoll, Bastian; Kress, Thomas; Künsken, Andreas; Lingemann, Joschka; Müller, Thomas; Nehrkorn, Alexander; Nowack, Andreas; Nugent, Ian Michael; Pistone, Claudia; Pooth, Oliver; Stahl, Achim; Aldaya Martin, Maria; Asawatangtrakuldee, Chayanit; Beernaert, Kelly; Behnke, Olaf; Behrens, Ulf; Bin Anuar, Afiq Aizuddin; Borras, Kerstin; Campbell, Alan; Connor, Patrick; Contreras-Campana, Christian; Costanza, Francesco; Diez Pardos, Carmen; Dolinska, Ganna; Eckerlin, Guenter; Eckstein, Doris; Eren, Engin; Gallo, Elisabetta; Garay Garcia, Jasone; Geiser, Achim; Gizhko, Andrii; Grados Luyando, Juan Manuel; Gunnellini, Paolo; Harb, Ali; Hauk, Johannes; Hempel, Maria; Jung, Hannes; Kalogeropoulos, Alexis; Karacheban, Olena; Kasemann, Matthias; Keaveney, James; Kleinwort, Claus; Korol, Ievgen; Krücker, Dirk; Lange, Wolfgang; Lelek, Aleksandra; Leonard, Jessica; Lipka, Katerina; Lobanov, Artur; Lohmann, Wolfgang; Mankel, Rainer; Melzer-Pellmann, Isabell-Alissandra; Meyer, Andreas Bernhard; Mittag, Gregor; Mnich, Joachim; Mussgiller, Andreas; Ntomari, Eleni; Pitzl, Daniel; Raspereza, Alexei; Roland, Benoit; Sahin, Mehmet Özgür; Saxena, Pooja; Schoerner-Sadenius, Thomas; Seitz, Claudia; Spannagel, Simon; Stefaniuk, Nazar; Van Onsem, Gerrit Patrick; Walsh, Roberval; Wissing, Christoph; Blobel, Volker; Centis Vignali, Matteo; Draeger, Arne-Rasmus; Dreyer, Torben; Garutti, Erika; Gonzalez, Daniel; Haller, Johannes; Hoffmann, Malte; Junkes, Alexandra; Klanner, Robert; Kogler, Roman; Kovalchuk, Nataliia; Lapsien, Tobias; Lenz, Teresa; Marchesini, Ivan; Marconi, Daniele; Meyer, Mareike; Niedziela, Marek; Nowatschin, Dominik; Pantaleo, Felice; Peiffer, Thomas; Perieanu, Adrian; Poehlsen, Jennifer; Sander, Christian; Scharf, Christian; Schleper, Peter; Schmidt, Alexander; Schumann, Svenja; Schwandt, Joern; Stadie, Hartmut; Steinbrück, Georg; Stober, Fred-Markus Helmut; Stöver, Marc; Tholen, Heiner; Troendle, Daniel; Usai, Emanuele; Vanelderen, Lukas; Vanhoefer, Annika; Vormwald, Benedikt; Barth, Christian; Baus, Colin; Berger, Joram; Butz, Erik; Chwalek, Thorsten; Colombo, Fabio; De Boer, Wim; Dierlamm, Alexander; Fink, Simon; Friese, Raphael; Giffels, Manuel; Gilbert, Andrew; Goldenzweig, Pablo; Haitz, Dominik; Hartmann, Frank; Heindl, Stefan Michael; Husemann, Ulrich; Katkov, Igor; Lobelle Pardo, Patricia; Maier, Benedikt; Mildner, Hannes; Mozer, Matthias Ulrich; Müller, Thomas; Plagge, Michael; Quast, Gunter; Rabbertz, Klaus; Röcker, Steffen; Roscher, Frank; Schröder, Matthias; Shvetsov, Ivan; Sieber, Georg; Simonis, Hans-Jürgen; Ulrich, Ralf; Wagner-Kuhr, Jeannine; Wayand, Stefan; Weber, Marc; Weiler, Thomas; Williamson, Shawn; Wöhrmann, Clemens; Wolf, Roger; Anagnostou, Georgios; Daskalakis, Georgios; Geralis, Theodoros; Giakoumopoulou, Viktoria Athina; Kyriakis, Aristotelis; Loukas, Demetrios; Topsis-Giotis, Iasonas; Kesisoglou, Stilianos; Panagiotou, Apostolos; Saoulidou, Niki; Tziaferi, Eirini; Evangelou, Ioannis; Flouris, Giannis; Foudas, Costas; Kokkas, Panagiotis; Loukas, Nikitas; Manthos, Nikolaos; Papadopoulos, Ioannis; Paradas, Evangelos; Filipovic, Nicolas; Bencze, Gyorgy; Hajdu, Csaba; Hidas, Pàl; Horvath, Dezso; Sikler, Ferenc; Veszpremi, Viktor; Vesztergombi, Gyorgy; Zsigmond, Anna Julia; Beni, Noemi; Czellar, Sandor; Karancsi, János; Makovec, Alajos; Molnar, Jozsef; Szillasi, Zoltan; Bartók, Márton; Raics, Peter; Trocsanyi, Zoltan Laszlo; Ujvari, Balazs; Bahinipati, Seema; Choudhury, Somnath; Mal, Prolay; Mandal, Koushik; Nayak, Aruna; Sahoo, Deepak Kumar; Sahoo, Niladribihari; Swain, Sanjay Kumar; Bansal, Sunil; Beri, Suman Bala; Bhatnagar, Vipin; Chawla, Ridhi; Bhawandeep, Bhawandeep; Kalsi, Amandeep Kaur; Kaur, Anterpreet; Kaur, Manjit; Kumar, Ramandeep; Mehta, Ankita; Mittal, Monika; Singh, Jasbir; Walia, Genius; Kumar, Ashok; Bhardwaj, Ashutosh; Choudhary, Brajesh C; Garg, Rocky Bala; Keshri, Sumit; Malhotra, Shivali; Naimuddin, Md; Nishu, Nishu; Ranjan, Kirti; Sharma, Ramkrishna; Sharma, Varun; Bhattacharya, Rajarshi; Bhattacharya, Satyaki; Chatterjee, Kalyanmoy; Dey, Sourav; Dutt, Suneel; Dutta, Suchandra; Ghosh, Shamik; Majumdar, Nayana; Modak, Atanu; Mondal, Kuntal; Mukhopadhyay, Supratik; Nandan, Saswati; Purohit, Arnab; Roy, Ashim; Roy, Debarati; Roy Chowdhury, Suvankar; Sarkar, Subir; Sharan, Manoj; Thakur, Shalini; Behera, Prafulla Kumar; Chudasama, Ruchi; Dutta, Dipanwita; Jha, Vishwajeet; Kumar, Vineet; Mohanty, Ajit Kumar; Netrakanti, Pawan Kumar; Pant, Lalit Mohan; Shukla, Prashant; Topkar, Anita; Aziz, Tariq; Dugad, Shashikant; Kole, Gouranga; Mahakud, Bibhuprasad; Mitra, Soureek; Mohanty, Gagan Bihari; Parida, Bibhuti; Sur, Nairit; Sutar, Bajrang; Banerjee, Sudeshna; Bhowmik, Sandeep; Dewanjee, Ram Krishna; Ganguly, Sanmay; Guchait, Monoranjan; Jain, Sandhya; Kumar, Sanjeev; Maity, Manas; Majumder, Gobinda; Mazumdar, Kajari; Sarkar, Tanmay; Wickramage, Nadeesha; Chauhan, Shubhanshu; Dube, Sourabh; Hegde, Vinay; Kapoor, Anshul; Kothekar, Kunal; Rane, Aditee; Sharma, Seema; Behnamian, Hadi; Chenarani, Shirin; Eskandari Tadavani, Esmaeel; Etesami, Seyed Mohsen; Fahim, Ali; Khakzad, Mohsen; Mohammadi Najafabadi, Mojtaba; Naseri, Mohsen; Paktinat Mehdiabadi, Saeid; Rezaei Hosseinabadi, Ferdos; Safarzadeh, Batool; Zeinali, Maryam; Felcini, Marta; Grunewald, Martin; Abbrescia, Marcello; Calabria, Cesare; Caputo, Claudio; Colaleo, Anna; Creanza, Donato; Cristella, Leonardo; De Filippis, Nicola; De Palma, Mauro; Fiore, Luigi; Iaselli, Giuseppe; Maggi, Giorgio; Maggi, Marcello; Miniello, Giorgia; My, Salvatore; Nuzzo, Salvatore; Pompili, Alexis; Pugliese, Gabriella; Radogna, Raffaella; Ranieri, Antonio; Selvaggi, Giovanna; Silvestris, Lucia; Venditti, Rosamaria; Verwilligen, Piet; Abbiendi, Giovanni; Battilana, Carlo; Bonacorsi, Daniele; Braibant-Giacomelli, Sylvie; Brigliadori, Luca; Campanini, Renato; Capiluppi, Paolo; Castro, Andrea; Cavallo, Francesca Romana; Chhibra, Simranjit Singh; Codispoti, Giuseppe; Cuffiani, Marco; Dallavalle, Gaetano-Marco; Fabbri, Fabrizio; Fanfani, Alessandra; Fasanella, Daniele; Giacomelli, Paolo; Grandi, Claudio; Guiducci, Luigi; Marcellini, Stefano; Masetti, Gianni; Montanari, Alessandro; Navarria, Francesco; Perrotta, Andrea; Rossi, Antonio; Rovelli, Tiziano; Siroli, Gian Piero; Tosi, Nicolò; Albergo, Sebastiano; Chiorboli, Massimiliano; Costa, Salvatore; Di Mattia, Alessandro; Giordano, Ferdinando; Potenza, Renato; Tricomi, Alessia; Tuve, Cristina; Barbagli, Giuseppe; Ciulli, Vitaliano; Civinini, Carlo; D'Alessandro, Raffaello; Focardi, Ettore; Gori, Valentina; Lenzi, Piergiulio; Meschini, Marco; Paoletti, Simone; Sguazzoni, Giacomo; Viliani, Lorenzo; Benussi, Luigi; Bianco, Stefano; Fabbri, Franco; Piccolo, Davide; Primavera, Federica; Calvelli, Valerio; Ferro, Fabrizio; Lo Vetere, Maurizio; Monge, Maria Roberta; Robutti, Enrico; Tosi, Silvano; Brianza, Luca; Dinardo, Mauro Emanuele; Fiorendi, Sara; Gennai, Simone; Ghezzi, Alessio; Govoni, Pietro; Malberti, Martina; Malvezzi, Sandra; Manzoni, Riccardo Andrea; Marzocchi, Badder; Menasce, Dario; Moroni, Luigi; Paganoni, Marco; Pedrini, Daniele; Pigazzini, Simone; Ragazzi, Stefano; Tabarelli de Fatis, Tommaso; Buontempo, Salvatore; Cavallo, Nicola; De Nardo, Guglielmo; Di Guida, Salvatore; Esposito, Marco; Fabozzi, Francesco; Iorio, Alberto Orso Maria; Lanza, Giuseppe; Lista, Luca; Meola, Sabino; Paolucci, Pierluigi; Sciacca, Crisostomo; Thyssen, Filip; Azzi, Patrizia; Bacchetta, Nicola; Benato, Lisa; Bisello, Dario; Boletti, Alessio; Carlin, Roberto; Carvalho Antunes De Oliveira, Alexandra; Checchia, Paolo; Dall'Osso, Martino; De Castro Manzano, Pablo; Dorigo, Tommaso; Dosselli, Umberto; Gasparini, Fabrizio; Gasparini, Ugo; Gozzelino, Andrea; Lacaprara, Stefano; Margoni, Martino; Meneguzzo, Anna Teresa; Pazzini, Jacopo; Pozzobon, Nicola; Ronchese, Paolo; Simonetto, Franco; Torassa, Ezio; Zanetti, Marco; Zotto, Pierluigi; Zucchetta, Alberto; Zumerle, Gianni; Braghieri, Alessandro; Magnani, Alice; Montagna, Paolo; Ratti, Sergio P; Re, Valerio; Riccardi, Cristina; Salvini, Paola; Vai, Ilaria; Vitulo, Paolo; Alunni Solestizi, Luisa; Bilei, Gian Mario; Ciangottini, Diego; Fanò, Livio; Lariccia, Paolo; Leonardi, Roberto; Mantovani, Giancarlo; Menichelli, Mauro; Saha, Anirban; Santocchia, Attilio; Androsov, Konstantin; Azzurri, Paolo; Bagliesi, Giuseppe; Bernardini, Jacopo; Boccali, Tommaso; Castaldi, Rino; Ciocci, Maria Agnese; Dell'Orso, Roberto; Donato, Silvio; Fedi, Giacomo; Giassi, Alessandro; Grippo, Maria Teresa; Ligabue, Franco; Lomtadze, Teimuraz; Martini, Luca; Messineo, Alberto; Palla, Fabrizio; Rizzi, Andrea; Savoy-Navarro, Aurore; Spagnolo, Paolo; Tenchini, Roberto; Tonelli, Guido; Venturi, Andrea; Verdini, Piero Giorgio; Barone, Luciano; Cavallari, Francesca; Cipriani, Marco; D'imperio, Giulia; Del Re, Daniele; Diemoz, Marcella; Gelli, Simone; Longo, Egidio; Margaroli, Fabrizio; Meridiani, Paolo; Organtini, Giovanni; Paramatti, Riccardo; Preiato, Federico; Rahatlou, Shahram; Rovelli, Chiara; Santanastasio, Francesco; Amapane, Nicola; Arcidiacono, Roberta; Argiro, Stefano; Arneodo, Michele; Bartosik, Nazar; Bellan, Riccardo; Biino, Cristina; Cartiglia, Nicolo; Cenna, Francesca; Costa, Marco; Covarelli, Roberto; Degano, Alessandro; Demaria, Natale; Finco, Linda; Kiani, Bilal; Mariotti, Chiara; Maselli, Silvia; Migliore, Ernesto; Monaco, Vincenzo; Monteil, Ennio; Obertino, Maria Margherita; Pacher, Luca; Pastrone, Nadia; Pelliccioni, Mario; Pinna Angioni, Gian Luca; Ravera, Fabio; Romero, Alessandra; Ruspa, Marta; Sacchi, Roberto; Shchelina, Ksenia; Sola, Valentina; Solano, Ada; Staiano, Amedeo; Traczyk, Piotr; Belforte, Stefano; Casarsa, Massimo; Cossutti, Fabio; Della Ricca, Giuseppe; La Licata, Chiara; Schizzi, Andrea; Zanetti, Anna; Kim, Dong Hee; Kim, Gui Nyun; Kim, Min Suk; Lee, Sangeun; Lee, Seh Wook; Oh, Young Do; Sekmen, Sezen; Son, Dong-Chul; Yang, Yu Chul; Lee, Ari; Kim, Hyunchul; Brochero Cifuentes, Javier Andres; Kim, Tae Jeong; Cho, Sungwoong; Choi, Suyong; Go, Yeonju; Gyun, Dooyeon; Ha, Seungkyu; Hong, Byung-Sik; Jo, Youngkwon; Kim, Yongsun; Lee, Byounghoon; Lee, Kisoo; Lee, Kyong Sei; Lee, Songkyo; Lim, Jaehoon; Park, Sung Keun; Roh, Youn; Almond, John; Kim, Junho; Lee, Haneol; Oh, Sung Bin; Radburn-Smith, Benjamin Charles; Seo, Seon-hee; Yang, Unki; Yoo, Hwi Dong; Yu, Geum Bong; Choi, Minkyoo; Kim, Hyunyong; Kim, Ji Hyun; Lee, Jason Sang Hun; Park, Inkyu; Ryu, Geonmo; Ryu, Min Sang; Choi, Young-Il; Goh, Junghwan; Hwang, Chanwook; Lee, Jongseok; Yu, Intae; Dudenas, Vytautas; Juodagalvis, Andrius; Vaitkus, Juozas; Ahmed, Ijaz; Ibrahim, Zainol Abidin; Komaragiri, Jyothsna Rani; Md Ali, Mohd Adli Bin; Mohamad Idris, Faridah; Wan Abdullah, Wan Ahmad Tajuddin; Yusli, Mohd Nizam; Zolkapli, Zukhaimira; Castilla-Valdez, Heriberto; De La Cruz-Burelo, Eduard; Heredia-De La Cruz, Ivan; Hernandez-Almada, Alberto; Lopez-Fernandez, Ricardo; Magaña Villalba, Ricardo; Mejia Guisao, Jhovanny; Sánchez Hernández, Alberto; Carrillo Moreno, Salvador; Oropeza Barrera, Cristina; Vazquez Valencia, Fabiola; Carpinteyro, Severiano; Pedraza, Isabel; Salazar Ibarguen, Humberto Antonio; Uribe Estrada, Cecilia; Morelos Pineda, Antonio; Krofcheck, David; Butler, Philip H; Ahmad, Ashfaq; Ahmad, Muhammad; Hassan, Qamar; Hoorani, Hafeez R; Khan, Wajid Ali; Shah, Mehar Ali; Shoaib, Muhammad; Waqas, Muhammad; Bialkowska, Helena; Bluj, Michal; Boimska, Bożena; Frueboes, Tomasz; Górski, Maciej; Kazana, Malgorzata; Nawrocki, Krzysztof; Romanowska-Rybinska, Katarzyna; Szleper, Michal; Zalewski, Piotr; Bunkowski, Karol; Byszuk, Adrian; Doroba, Krzysztof; Kalinowski, Artur; Konecki, Marcin; Krolikowski, Jan; Misiura, Maciej; Olszewski, Michal; Walczak, Marek; Bargassa, Pedrame; Beirão Da Cruz E Silva, Cristóvão; Di Francesco, Agostino; Faccioli, Pietro; Ferreira Parracho, Pedro Guilherme; Gallinaro, Michele; Hollar, Jonathan; Leonardo, Nuno; Lloret Iglesias, Lara; Nemallapudi, Mythra Varun; Rodrigues Antunes, Joao; Seixas, Joao; Toldaiev, Oleksii; Vadruccio, Daniele; Varela, Joao; Vischia, Pietro; Afanasiev, Serguei; Bunin, Pavel; Gavrilenko, Mikhail; Golutvin, Igor; Gorbunov, Ilya; Kamenev, Alexey; Karjavin, Vladimir; Lanev, Alexander; Malakhov, Alexander; Matveev, Viktor; Moisenz, Petr; Palichik, Vladimir; Perelygin, Victor; Shmatov, Sergey; Shulha, Siarhei; Skatchkov, Nikolai; Smirnov, Vitaly; Voytishin, Nikolay; Zarubin, Anatoli; Chtchipounov, Leonid; Golovtsov, Victor; Ivanov, Yury; Kim, Victor; Kuznetsova, Ekaterina; Murzin, Victor; Oreshkin, Vadim; Sulimov, Valentin; Vorobyev, Alexey; Andreev, Yuri; Dermenev, Alexander; Gninenko, Sergei; Golubev, Nikolai; Karneyeu, Anton; Kirsanov, Mikhail; Krasnikov, Nikolai; Pashenkov, Anatoli; Tlisov, Danila; Toropin, Alexander; Epshteyn, Vladimir; Gavrilov, Vladimir; Lychkovskaya, Natalia; Popov, Vladimir; Pozdnyakov, Ivan; Safronov, Grigory; Spiridonov, Alexander; Toms, Maria; Vlasov, Evgueni; Zhokin, Alexander; Bylinkin, Alexander; Chadeeva, Marina; Chistov, Ruslan; Rusinov, Vladimir; Andreev, Vladimir; Azarkin, Maksim; Dremin, Igor; Kirakosyan, Martin; Leonidov, Andrey; Rusakov, Sergey V; Terkulov, Adel; Baskakov, Alexey; Belyaev, Andrey; Boos, Edouard; Dubinin, Mikhail; Dudko, Lev; Ershov, Alexander; Gribushin, Andrey; Klyukhin, Vyacheslav; Kodolova, Olga; Lokhtin, Igor; Miagkov, Igor; Obraztsov, Stepan; Petrushanko, Sergey; Savrin, Viktor; Snigirev, Alexander; Blinov, Vladimir; Skovpen, Yuri; Azhgirey, Igor; Bayshev, Igor; Bitioukov, Sergei; Elumakhov, Dmitry; Kachanov, Vassili; Kalinin, Alexey; Konstantinov, Dmitri; Krychkine, Victor; Petrov, Vladimir; Ryutin, Roman; Sobol, Andrei; Troshin, Sergey; Tyurin, Nikolay; Uzunian, Andrey; Volkov, Alexey; Adzic, Petar; Cirkovic, Predrag; Devetak, Damir; Dordevic, Milos; Milosevic, Jovan; Rekovic, Vladimir; Alcaraz Maestre, Juan; Barrio Luna, Mar; Calvo, Enrique; Cerrada, Marcos; Chamizo Llatas, Maria; Colino, Nicanor; De La Cruz, Begona; Delgado Peris, Antonio; Escalante Del Valle, Alberto; Fernandez Bedoya, Cristina; Fernández Ramos, Juan Pablo; Flix, Jose; Fouz, Maria Cruz; Garcia-Abia, Pablo; Gonzalez Lopez, Oscar; Goy Lopez, Silvia; Hernandez, Jose M; Josa, Maria Isabel; Navarro De Martino, Eduardo; Pérez-Calero Yzquierdo, Antonio María; Puerta Pelayo, Jesus; Quintario Olmeda, Adrián; Redondo, Ignacio; Romero, Luciano; Senghi Soares, Mara; de Trocóniz, Jorge F; Missiroli, Marino; Moran, Dermot; Cuevas, Javier; Fernandez Menendez, Javier; Gonzalez Caballero, Isidro; González Fernández, Juan Rodrigo; Palencia Cortezon, Enrique; Sanchez Cruz, Sergio; Suárez Andrés, Ignacio; Vizan Garcia, Jesus Manuel; Cabrillo, Iban Jose; Calderon, Alicia; Castiñeiras De Saa, Juan Ramon; Curras, Esteban; Fernandez, Marcos; Garcia-Ferrero, Juan; Gomez, Gervasio; Lopez Virto, Amparo; Marco, Jesus; Martinez Rivero, Celso; Matorras, Francisco; Piedra Gomez, Jonatan; Rodrigo, Teresa; Ruiz-Jimeno, Alberto; Scodellaro, Luca; Trevisani, Nicolò; Vila, Ivan; Vilar Cortabitarte, Rocio; Abbaneo, Duccio; Auffray, Etiennette; Auzinger, Georg; Bachtis, Michail; Baillon, Paul; Ball, Austin; Barney, David; Bloch, Philippe; Bocci, Andrea; Bonato, Alessio; Botta, Cristina; Camporesi, Tiziano; Castello, Roberto; Cepeda, Maria; Cerminara, Gianluca; D'Alfonso, Mariarosaria; D'Enterria, David; Dabrowski, Anne; Daponte, Vincenzo; David Tinoco Mendes, Andre; De Gruttola, Michele; De Roeck, Albert; Di Marco, Emanuele; Dobson, Marc; Dorney, Brian; Du Pree, Tristan; Duggan, Daniel; Dünser, Marc; Dupont, Niels; Elliott-Peisert, Anna; Fartoukh, Stephane; Franzoni, Giovanni; Fulcher, Jonathan; Funk, Wolfgang; Gigi, Dominique; Gill, Karl; Girone, Maria; Glege, Frank; Gulhan, Doga; Gundacker, Stefan; Guthoff, Moritz; Hammer, Josef; Harris, Philip; Hegeman, Jeroen; Innocente, Vincenzo; Janot, Patrick; Kieseler, Jan; Kirschenmann, Henning; Knünz, Valentin; Kornmayer, Andreas; Kortelainen, Matti J; Kousouris, Konstantinos; Krammer, Manfred; Lange, Clemens; Lecoq, Paul; Lourenco, Carlos; Lucchini, Marco Toliman; Malgeri, Luca; Mannelli, Marcello; Martelli, Arabella; Meijers, Frans; Merlin, Jeremie Alexandre; Mersi, Stefano; Meschi, Emilio; Moortgat, Filip; Morovic, Srecko; Mulders, Martijn; Neugebauer, Hannes; Orfanelli, Styliani; Orsini, Luciano; Pape, Luc; Perez, Emmanuelle; Peruzzi, Marco; Petrilli, Achille; Petrucciani, Giovanni; Pfeiffer, Andreas; Pierini, Maurizio; Racz, Attila; Reis, Thomas; Rolandi, Gigi; Rovere, Marco; Ruan, Manqi; Sakulin, Hannes; Sauvan, Jean-Baptiste; Schäfer, Christoph; Schwick, Christoph; Seidel, Markus; Sharma, Archana; Silva, Pedro; Sphicas, Paraskevas; Steggemann, Jan; Stoye, Markus; Takahashi, Yuta; Tosi, Mia; Treille, Daniel; Triossi, Andrea; Tsirou, Andromachi; Veckalns, Viesturs; Veres, Gabor Istvan; Wardle, Nicholas; Zagoździńska, Agnieszka; Zeuner, Wolfram Dietrich; Bertl, Willi; Deiters, Konrad; Erdmann, Wolfram; Horisberger, Roland; Ingram, Quentin; Kaestli, Hans-Christian; Kotlinski, Danek; Langenegger, Urs; Rohe, Tilman; Bachmair, Felix; Bäni, Lukas; Bianchini, Lorenzo; Casal, Bruno; Dissertori, Günther; Dittmar, Michael; Donegà, Mauro; Grab, Christoph; Heidegger, Constantin; Hits, Dmitry; Hoss, Jan; Kasieczka, Gregor; Lecomte, Pierre; Lustermann, Werner; Mangano, Boris; Marionneau, Matthieu; Martinez Ruiz del Arbol, Pablo; Masciovecchio, Mario; Meinhard, Maren Tabea; Meister, Daniel; Micheli, Francesco; Musella, Pasquale; Nessi-Tedaldi, Francesca; Pandolfi, Francesco; Pata, Joosep; Pauss, Felicitas; Perrin, Gaël; Perrozzi, Luca; Quittnat, Milena; Rossini, Marco; Schönenberger, Myriam; Starodumov, Andrei; Tavolaro, Vittorio Raoul; Theofilatos, Konstantinos; Wallny, Rainer; Aarrestad, Thea Klaeboe; Amsler, Claude; Caminada, Lea; Canelli, Maria Florencia; De Cosa, Annapaola; Galloni, Camilla; Hinzmann, Andreas; Hreus, Tomas; Kilminster, Benjamin; Ngadiuba, Jennifer; Pinna, Deborah; Rauco, Giorgia; Robmann, Peter; Salerno, Daniel; Yang, Yong; Candelise, Vieri; Doan, Thi Hien; Jain, Shilpi; Khurana, Raman; Konyushikhin, Maxim; Kuo, Chia-Ming; Lin, Willis; Lu, Yun-Ju; Pozdnyakov, Andrey; Yu, Shin-Shan; Kumar, Arun; Chang, Paoti; Chang, You-Hao; Chang, Yu-Wei; Chao, Yuan; Chen, Kai-Feng; Chen, Po-Hsun; Dietz, Charles; Fiori, Francesco; Hou, George Wei-Shu; Hsiung, Yee; Liu, Yueh-Feng; Lu, Rong-Shyang; Miñano Moya, Mercedes; Paganis, Efstathios; Psallidas, Andreas; Tsai, Jui-fa; Tzeng, Yeng-Ming; Asavapibhop, Burin; Singh, Gurpreet; Srimanobhas, Norraphat; Suwonjandee, Narumon; Cerci, Salim; Damarseckin, Serdal; Demiroglu, Zuhal Seyma; Dozen, Candan; Dumanoglu, Isa; Girgis, Semiray; Gokbulut, Gul; Guler, Yalcin; Gurpinar, Emine; Hos, Ilknur; Kangal, Evrim Ersin; Kara, Ozgun; Kayis Topaksu, Aysel; Kiminsu, Ugur; Oglakci, Mehmet; Onengut, Gulsen; Ozdemir, Kadri; Sunar Cerci, Deniz; Tali, Bayram; Turkcapar, Semra; Zorbakir, Ibrahim Soner; Zorbilmez, Caglar; Bilin, Bugra; Bilmis, Selcuk; Isildak, Bora; Karapinar, Guler; Yalvac, Metin; Zeyrek, Mehmet; Gülmez, Erhan; Kaya, Mithat; Kaya, Ozlem; Yetkin, Elif Asli; Yetkin, Taylan; Cakir, Altan; Cankocak, Kerem; Sen, Sercan; Grynyov, Boris; Levchuk, Leonid; Sorokin, Pavel; Aggleton, Robin; Ball, Fionn; Beck, Lana; Brooke, James John; Burns, Douglas; Clement, Emyr; Cussans, David; Flacher, Henning; Goldstein, Joel; Grimes, Mark; Heath, Greg P; Heath, Helen F; Jacob, Jeson; Kreczko, Lukasz; Lucas, Chris; Newbold, Dave M; Paramesvaran, Sudarshan; Poll, Anthony; Sakuma, Tai; Seif El Nasr-storey, Sarah; Smith, Dominic; Smith, Vincent J; Belyaev, Alexander; Brew, Christopher; Brown, Robert M; Calligaris, Luigi; Cieri, Davide; Cockerill, David JA; Coughlan, John A; Harder, Kristian; Harper, Sam; Olaiya, Emmanuel; Petyt, David; Shepherd-Themistocleous, Claire; Thea, Alessandro; Tomalin, Ian R; Williams, Thomas; Baber, Mark; Bainbridge, Robert; Buchmuller, Oliver; Bundock, Aaron; Burton, Darren; Casasso, Stefano; Citron, Matthew; Colling, David; Corpe, Louie; Dauncey, Paul; Davies, Gavin; De Wit, Adinda; Della Negra, Michel; Di Maria, Riccardo; Dunne, Patrick; Elwood, Adam; Futyan, David; Haddad, Yacine; Hall, Geoffrey; Iles, Gregory; James, Thomas; Lane, Rebecca; Laner, Christian; Lucas, Robyn; Lyons, Louis; Magnan, Anne-Marie; Malik, Sarah; Mastrolorenzo, Luca; Nash, Jordan; Nikitenko, Alexander; Pela, Joao; Penning, Bjoern; Pesaresi, Mark; Raymond, David Mark; Richards, Alexander; Rose, Andrew; Seez, Christopher; Summers, Sioni; Tapper, Alexander; Uchida, Kirika; Vazquez Acosta, Monica; Virdee, Tejinder; Wright, Jack; Zenz, Seth Conrad; Cole, Joanne; Hobson, Peter R; Khan, Akram; Kyberd, Paul; Leslie, Dawn; Reid, Ivan; Symonds, Philip; Teodorescu, Liliana; Turner, Mark; Borzou, Ahmad; Call, Kenneth; Dittmann, Jay; Hatakeyama, Kenichi; Liu, Hongxuan; Pastika, Nathaniel; Charaf, Otman; Cooper, Seth; Henderson, Conor; Rumerio, Paolo; West, Christopher; Arcaro, Daniel; Avetisyan, Aram; Bose, Tulika; Gastler, Daniel; Rankin, Dylan; Richardson, Clint; Rohlf, James; Sulak, Lawrence; Zou, David; Benelli, Gabriele; Berry, Edmund; Cutts, David; Garabedian, Alex; Hakala, John; Heintz, Ulrich; Hogan, Julie Managan; Jesus, Orduna; Laird, Edward; Landsberg, Greg; Mao, Zaixing; Narain, Meenakshi; Piperov, Stefan; Sagir, Sinan; Spencer, Eric; Syarif, Rizki; Breedon, Richard; Breto, Guillermo; Burns, Dustin; Calderon De La Barca Sanchez, Manuel; Chauhan, Sushil; Chertok, Maxwell; Conway, John; Conway, Rylan; Cox, Peter Timothy; Erbacher, Robin; Flores, Chad; Funk, Garrett; Gardner, Michael; Ko, Winston; Lander, Richard; Mclean, Christine; Mulhearn, Michael; Pellett, Dave; Pilot, Justin; Shalhout, Shalhout; Smith, John; Squires, Michael; Stolp, Dustin; Tripathi, Mani; Wilbur, Scott; Yohay, Rachel; Cousins, Robert; Everaerts, Pieter; Florent, Alice; Hauser, Jay; Ignatenko, Mikhail; Saltzberg, David; Takasugi, Eric; Valuev, Vyacheslav; Weber, Matthias; Burt, Kira; Clare, Robert; Ellison, John Anthony; Gary, J William; Hanson, Gail; Heilman, Jesse; Jandir, Pawandeep; Kennedy, Elizabeth; Lacroix, Florent; Long, Owen Rosser; Olmedo Negrete, Manuel; Paneva, Mirena Ivova; Shrinivas, Amithabh; Si, Weinan; Wei, Hua; Wimpenny, Stephen; Yates, Brent; Branson, James G; Cerati, Giuseppe Benedetto; Cittolin, Sergio; Derdzinski, Mark; Gerosa, Raffaele; Holzner, André; Klein, Daniel; Krutelyov, Vyacheslav; Letts, James; Macneill, Ian; Olivito, Dominick; Padhi, Sanjay; Pieri, Marco; Sani, Matteo; Sharma, Vivek; Simon, Sean; Tadel, Matevz; Vartak, Adish; Wasserbaech, Steven; Welke, Charles; Wood, John; Würthwein, Frank; Yagil, Avraham; Zevi Della Porta, Giovanni; Bhandari, Rohan; Bradmiller-Feld, John; Campagnari, Claudio; Dishaw, Adam; Dutta, Valentina; Flowers, Kristen; Franco Sevilla, Manuel; Geffert, Paul; George, Christopher; Golf, Frank; Gouskos, Loukas; Gran, Jason; Heller, Ryan; Incandela, Joe; Mccoll, Nickolas; Mullin, Sam Daniel; Ovcharova, Ana; Richman, Jeffrey; Stuart, David; Suarez, Indara; Yoo, Jaehyeok; Anderson, Dustin; Apresyan, Artur; Bendavid, Joshua; Bornheim, Adolf; Bunn, Julian; Chen, Yi; Duarte, Javier; Lawhorn, Jay Mathew; Mott, Alexander; Newman, Harvey B; Pena, Cristian; Spiropulu, Maria; Vlimant, Jean-Roch; Xie, Si; Zhu, Ren-Yuan; Andrews, Michael Benjamin; Azzolini, Virginia; Ferguson, Thomas; Paulini, Manfred; Russ, James; Sun, Menglei; Vogel, Helmut; Vorobiev, Igor; Cumalat, John Perry; Ford, William T; Jensen, Frank; Johnson, Andrew; Krohn, Michael; Mulholland, Troy; Stenson, Kevin; Wagner, Stephen Robert; Alexander, James; Chaves, Jorge; Chu, Jennifer; Dittmer, Susan; Mcdermott, Kevin; Mirman, Nathan; Nicolas Kaufman, Gala; Patterson, Juliet Ritchie; Rinkevicius, Aurelijus; Ryd, Anders; Skinnari, Louise; Soffi, Livia; Tan, Shao Min; Tao, Zhengcheng; Thom, Julia; Tucker, Jordan; Wittich, Peter; Zientek, Margaret; Winn, Dave; Abdullin, Salavat; Albrow, Michael; Apollinari, Giorgio; Banerjee, Sunanda; Bauerdick, Lothar AT; Beretvas, Andrew; Berryhill, Jeffrey; Bhat, Pushpalatha C; Bolla, Gino; Burkett, Kevin; Butler, Joel Nathan; Cheung, Harry; Chlebana, Frank; Cihangir, Selcuk; Cremonesi, Matteo; Elvira, Victor Daniel; Fisk, Ian; Freeman, Jim; Gottschalk, Erik; Gray, Lindsey; Green, Dan; Grünendahl, Stefan; Gutsche, Oliver; Hare, Daryl; Harris, Robert M; Hasegawa, Satoshi; Hirschauer, James; Hu, Zhen; Jayatilaka, Bodhitha; Jindariani, Sergo; Johnson, Marvin; Joshi, Umesh; Klima, Boaz; Kreis, Benjamin; Lammel, Stephan; Linacre, Jacob; Lincoln, Don; Lipton, Ron; Liu, Tiehui; Lopes De Sá, Rafael; Lykken, Joseph; Maeshima, Kaori; Magini, Nicolo; Marraffino, John Michael; Maruyama, Sho; Mason, David; McBride, Patricia; Merkel, Petra; Mrenna, Stephen; Nahn, Steve; Newman-Holmes, Catherine; O'Dell, Vivian; Pedro, Kevin; Prokofyev, Oleg; Rakness, Gregory; Ristori, Luciano; Sexton-Kennedy, Elizabeth; Soha, Aron; Spalding, William J; Spiegel, Leonard; Stoynev, Stoyan; Strobbe, Nadja; Taylor, Lucas; Tkaczyk, Slawek; Tran, Nhan Viet; Uplegger, Lorenzo; Vaandering, Eric Wayne; Vernieri, Caterina; Verzocchi, Marco; Vidal, Richard; Wang, Michael; Weber, Hannsjoerg Artur; Whitbeck, Andrew; Acosta, Darin; Avery, Paul; Bortignon, Pierluigi; Bourilkov, Dimitri; Brinkerhoff, Andrew; Carnes, Andrew; Carver, Matthew; Curry, David; Das, Souvik; Field, Richard D; Furic, Ivan-Kresimir; Konigsberg, Jacobo; Korytov, Andrey; Ma, Peisen; Matchev, Konstantin; Mei, Hualin; Milenovic, Predrag; Mitselmakher, Guenakh; Rank, Douglas; Shchutska, Lesya; Sperka, David; Thomas, Laurent; Wang, Jian; Wang, Sean-Jiun; Yelton, John; Linn, Stephan; Markowitz, Pete; Martinez, German; Rodriguez, Jorge Luis; Ackert, Andrew; Adams, Jordon Rowe; Adams, Todd; Askew, Andrew; Bein, Samuel; Diamond, Brendan; Hagopian, Sharon; Hagopian, Vasken; Johnson, Kurtis F; Khatiwada, Ajeeta; Prosper, Harrison; Santra, Arka; Weinberg, Marc; Baarmand, Marc M; Bhopatkar, Vallary; Colafranceschi, Stefano; Hohlmann, Marcus; Noonan, Daniel; Roy, Titas; Yumiceva, Francisco; Adams, Mark Raymond; Apanasevich, Leonard; Berry, Douglas; Betts, Russell Richard; Bucinskaite, Inga; Cavanaugh, Richard; Evdokimov, Olga; Gauthier, Lucie; Gerber, Cecilia Elena; Hofman, David Jonathan; Kurt, Pelin; O'Brien, Christine; Sandoval Gonzalez, Irving Daniel; Turner, Paul; Varelas, Nikos; Wang, Hui; Wu, Zhenbin; Zakaria, Mohammed; Zhang, Jingyu; Bilki, Burak; Clarida, Warren; Dilsiz, Kamuran; Durgut, Süleyman; Gandrajula, Reddy Pratap; Haytmyradov, Maksat; Khristenko, Viktor; Merlo, Jean-Pierre; Mermerkaya, Hamit; Mestvirishvili, Alexi; Moeller, Anthony; Nachtman, Jane; Ogul, Hasan; Onel, Yasar; Ozok, Ferhat; Penzo, Aldo; Snyder, Christina; Tiras, Emrah; Wetzel, James; Yi, Kai; Anderson, Ian; Blumenfeld, Barry; Cocoros, Alice; Eminizer, Nicholas; Fehling, David; Feng, Lei; Gritsan, Andrei; Maksimovic, Petar; Osherson, Marc; Roskes, Jeffrey; Sarica, Ulascan; Swartz, Morris; Xiao, Meng; Xin, Yongjie; You, Can; Al-bataineh, Ayman; Baringer, Philip; Bean, Alice; Boren, Samuel; Bowen, James; Bruner, Christopher; Castle, James; Forthomme, Laurent; Kenny III, Raymond Patrick; Kropivnitskaya, Anna; Majumder, Devdatta; Mcbrayer, William; Murray, Michael; Sanders, Stephen; Stringer, Robert; Tapia Takaki, Daniel; Wang, Quan; Ivanov, Andrew; Kaadze, Ketino; Khalil, Sadia; Maravin, Yurii; Mohammadi, Abdollah; Saini, Lovedeep Kaur; Skhirtladze, Nikoloz; Toda, Sachiko; Rebassoo, Finn; Wright, Douglas; Anelli, Christopher; Baden, Drew; Baron, Owen; Belloni, Alberto; Calvert, Brian; Eno, Sarah Catherine; Ferraioli, Charles; Gomez, Jaime; Hadley, Nicholas John; Jabeen, Shabnam; Kellogg, Richard G; Kolberg, Ted; Kunkle, Joshua; Lu, Ying; Mignerey, Alice; Ricci-Tam, Francesca; Shin, Young Ho; Skuja, Andris; Tonjes, Marguerite; Tonwar, Suresh C; Abercrombie, Daniel; Allen, Brandon; Apyan, Aram; Barbieri, Richard; Baty, Austin; Bi, Ran; Bierwagen, Katharina; Brandt, Stephanie; Busza, Wit; Cali, Ivan Amos; Demiragli, Zeynep; Di Matteo, Leonardo; Gomez Ceballos, Guillelmo; Goncharov, Maxim; Hsu, Dylan; Iiyama, Yutaro; Innocenti, Gian Michele; Klute, Markus; Kovalskyi, Dmytro; Krajczar, Krisztian; Lai, Yue Shi; Lee, Yen-Jie; Levin, Andrew; Luckey, Paul David; Marini, Andrea Carlo; Mcginn, Christopher; Mironov, Camelia; Narayanan, Siddharth; Niu, Xinmei; Paus, Christoph; Roland, Christof; Roland, Gunther; Salfeld-Nebgen, Jakob; Stephans, George; Sumorok, Konstanty; Tatar, Kaya; Varma, Mukund; Velicanu, Dragos; Veverka, Jan; Wang, Jing; Wang, Ta-Wei; Wyslouch, Bolek; Yang, Mingming; Zhukova, Victoria; Benvenuti, Alberto; Chatterjee, Rajdeep Mohan; Evans, Andrew; Finkel, Alexey; Gude, Alexander; Hansen, Peter; Kalafut, Sean; Kao, Shih-Chuan; Kubota, Yuichi; Lesko, Zachary; Mans, Jeremy; Nourbakhsh, Shervin; Ruckstuhl, Nicole; Rusack, Roger; Tambe, Norbert; Turkewitz, Jared; Acosta, John Gabriel; Oliveros, Sandra; Avdeeva, Ekaterina; Bartek, Rachel; Bloom, Kenneth; Claes, Daniel R; Dominguez, Aaron; Fangmeier, Caleb; Gonzalez Suarez, Rebeca; Kamalieddin, Rami; Kravchenko, Ilya; Malta Rodrigues, Alan; Meier, Frank; Monroy, Jose; Siado, Joaquin Emilo; Snow, Gregory R; Stieger, Benjamin; Alyari, Maral; Dolen, James; George, Jimin; Godshalk, Andrew; Harrington, Charles; Iashvili, Ia; Kaisen, Josh; Kharchilava, Avto; Kumar, Ashish; Parker, Ashley; Rappoccio, Salvatore; Roozbahani, Bahareh; Alverson, George; Barberis, Emanuela; Baumgartel, Darin; Hortiangtham, Apichart; Massironi, Andrea; Morse, David Michael; Nash, David; Orimoto, Toyoko; Teixeira De Lima, Rafael; Trocino, Daniele; Wang, Ren-Jie; Wood, Darien; Bhattacharya, Saptaparna; Hahn, Kristan Allan; Kubik, Andrew; Kumar, Ajay; Low, Jia Fu; Mucia, Nicholas; Odell, Nathaniel; Pollack, Brian; Schmitt, Michael Henry; Sung, Kevin; Trovato, Marco; Velasco, Mayda; Dev, Nabarun; Hildreth, Michael; Hurtado Anampa, Kenyi; Jessop, Colin; Karmgard, Daniel John; Kellams, Nathan; Lannon, Kevin; Marinelli, Nancy; Meng, Fanbo; Mueller, Charles; Musienko, Yuri; Planer, Michael; Reinsvold, Allison; Ruchti, Randy; Smith, Geoffrey; Taroni, Silvia; Wayne, Mitchell; Wolf, Matthias; Woodard, Anna; Alimena, Juliette; Antonelli, Louis; Brinson, Jessica; Bylsma, Ben; Durkin, Lloyd Stanley; Flowers, Sean; Francis, Brian; Hart, Andrew; Hill, Christopher; Hughes, Richard; Ji, Weifeng; Liu, Bingxuan; Luo, Wuming; Puigh, Darren; Winer, Brian L; Wulsin, Howard Wells; Cooperstein, Stephane; Driga, Olga; Elmer, Peter; Hardenbrook, Joshua; Hebda, Philip; Lange, David; Luo, Jingyu; Marlow, Daniel; Medvedeva, Tatiana; Mei, Kelvin; Mooney, Michael; Olsen, James; Palmer, Christopher; Piroué, Pierre; Stickland, David; Tully, Christopher; Zuranski, Andrzej; Malik, Sudhir; Barker, Anthony; Barnes, Virgil E; Folgueras, Santiago; Gutay, Laszlo; Jha, Manoj; Jones, Matthew; Jung, Andreas Werner; Jung, Kurt; Miller, David Harry; Neumeister, Norbert; Shi, Xin; Sun, Jian; Svyatkovskiy, Alexey; Wang, Fuqiang; Xie, Wei; Xu, Lingshan; Parashar, Neeti; Stupak, John; Adair, Antony; Akgun, Bora; Chen, Zhenyu; Ecklund, Karl Matthew; Geurts, Frank JM; Guilbaud, Maxime; Li, Wei; Michlin, Benjamin; Northup, Michael; Padley, Brian Paul; Redjimi, Radia; Roberts, Jay; Rorie, Jamal; Tu, Zhoudunming; Zabel, James; Betchart, Burton; Bodek, Arie; de Barbaro, Pawel; Demina, Regina; Duh, Yi-ting; Ferbel, Thomas; Galanti, Mario; Garcia-Bellido, Aran; Han, Jiyeon; Hindrichs, Otto; Khukhunaishvili, Aleko; Lo, Kin Ho; Tan, Ping; Verzetti, Mauro; Agapitos, Antonis; Chou, John Paul; Contreras-Campana, Emmanuel; Gershtein, Yuri; Gómez Espinosa, Tirso Alejandro; Halkiadakis, Eva; Heindl, Maximilian; Hidas, Dean; Hughes, Elliot; Kaplan, Steven; Kunnawalkam Elayavalli, Raghav; Kyriacou, Savvas; Lath, Amitabh; Nash, Kevin; Saka, Halil; Salur, Sevil; Schnetzer, Steve; Sheffield, David; Somalwar, Sunil; Stone, Robert; Thomas, Scott; Thomassen, Peter; Walker, Matthew; Foerster, Mark; Heideman, Joseph; Riley, Grant; Rose, Keith; Spanier, Stefan; Thapa, Krishna; Bouhali, Othmane; Celik, Ali; Dalchenko, Mykhailo; De Mattia, Marco; Delgado, Andrea; Dildick, Sven; Eusebi, Ricardo; Gilmore, Jason; Huang, Tao; Juska, Evaldas; Kamon, Teruki; Mueller, Ryan; Pakhotin, Yuriy; Patel, Rishi; Perloff, Alexx; Perniè, Luca; Rathjens, Denis; Rose, Anthony; Safonov, Alexei; Tatarinov, Aysen; Ulmer, Keith; Akchurin, Nural; Cowden, Christopher; Damgov, Jordan; De Guio, Federico; Dragoiu, Cosmin; Dudero, Phillip Russell; Faulkner, James; Kunori, Shuichi; Lamichhane, Kamal; Lee, Sung Won; Libeiro, Terence; Peltola, Timo; Undleeb, Sonaina; Volobouev, Igor; Wang, Zhixing; Delannoy, Andrés G; Greene, Senta; Gurrola, Alfredo; Janjam, Ravi; Johns, Willard; Maguire, Charles; Melo, Andrew; Ni, Hong; Sheldon, Paul; Tuo, Shengquan; Velkovska, Julia; Xu, Qiao; Arenton, Michael Wayne; Barria, Patrizia; Cox, Bradley; Goodell, Joseph; Hirosky, Robert; Ledovskoy, Alexander; Li, Hengne; Neu, Christopher; Sinthuprasith, Tutanon; Sun, Xin; Wang, Yanchu; Wolfe, Evan; Xia, Fan; Clarke, Christopher; Harr, Robert; Karchin, Paul Edmund; Lamichhane, Pramod; Sturdy, Jared; Belknap, Donald; Dasu, Sridhara; Dodd, Laura; Duric, Senka; Gomber, Bhawna; Grothe, Monika; Herndon, Matthew; Hervé, Alain; Klabbers, Pamela; Lanaro, Armando; Levine, Aaron; Long, Kenneth; Loveless, Richard; Ojalvo, Isabel; Perry, Thomas; Polese, Giovanni; Ruggles, Tyler; Savin, Alexander; Smith, Nicholas; Smith, Wesley H; Taylor, Devin; Woods, Nathaniel

    2017-02-10

    Measurements of two- and multi-particle angular correlations in pp collisions at $\\sqrt{s} = $ 5, 7, and 13 TeV are presented as a function of charged-particle multiplicity. The data, corresponding to integrated luminosities of 1.0 pb$^{-1}$ (5 TeV), 6.2 pb$^{-1}$ (7 TeV), and 0.7 pb$^{-1}$ (13 TeV), were collected using the CMS detector at the LHC. The second-order ($v_2$) and third-order ($v_3$) azimuthal anisotropy harmonics of unidentified charged particles, as well as $v_2$ of $\\mathrm{ K_S }^0$ and $\\Lambda/\\overline{\\Lambda}$ particles, are extracted from long-range two-particle correlations as functions of particle multiplicity and transverse momentum. For high-multiplicity pp events, a mass ordering is observed for the $v_2$ values of charged hadrons (mostly pions), $\\mathrm{ K_S }^0$, and $\\Lambda/\\overline{\\Lambda}$, with lighter particle species exhibiting a stronger azimuthal anisotropy signal below $p_{\\mathrm{T}} \\approx 2$ GeV/$c$. For 13 TeV data, the $v_2$ signals are also extracted from fou...

  13. Analysis of the differential cross sections for the reaction pp{yields}ppK{sup +}K{sup -} in view of the K{sup +}K{sup -} interaction

    Energy Technology Data Exchange (ETDEWEB)

    Silarski, M.

    2008-07-15

    Measurements of the pp{yields}ppK{sup +}K{sup -} reaction, performed with the experiment COSY-11 at the Cooler Synchrotron COSY, show a significant difference between the obtained excitation function and theoretical expectations including pp-FSI. The discrepancy may be assigned to the influence of K{sup +}K{sup -} or K{sup -}p interaction. This interaction should manifest itself in the distributions of the differential cross section. This thesis presents an analysis of event distributions as a function of the invariant masses of two particle subsystems. In particular in the analysis two generalizations of the Dalitz plot proposed by Goldhaber and Nyborg are used. The present Investigations are based on the experimental data determined by the COSY-11 collaboration from two measurements at excess energies of Q=10 MeV and 28 MeV. The experimental distributions are compared to results of Monte Carlo simulations generated with various parameters of the K{sup +}K{sup -} and K{sup -}p interaction. The values of the K{sup +}K{sup -} scattering length, extracted from two data sets for Q=10 MeV and 28 MeV amount to: a{sub K{sup +}}{sub K{sup -}}=(11{+-}8)+i(0{+-}6) fm for Q=10 MeV, and a{sub K{sup +}}{sub K{sup -}}=(0.2{+-}0.2)+i(0.0{+-}0.5) fm for Q=28 MeV. Due to the low statistics, the extracted values have large uncertainties and are consistent with very low values of the real and imaginary part of the scattering length. (orig.)

  14. Non-Hermitian interaction representation and its use in relativistic quantum mechanics

    Czech Academy of Sciences Publication Activity Database

    Znojil, Miloslav

    2017-01-01

    Roč. 385, č. 10 (2017), s. 162-179 ISSN 0003-4916 R&D Projects: GA ČR GA16-22945S Institutional support: RVO:61389005 Keywords : unitary quantum systems * non-Hermitian version of Dirac's interaction picture * complete set of time-evolution equations * application in relativistic quantum mechanics * Klein-Gordon example with space-time-dependent mass Subject RIV: BE - Theoretical Physics OBOR OECD: Atomic, molecular and chemical physics ( physics of atoms and molecules including collision, interaction with radiation, magnetic resonances, Mössbauer effect) Impact factor: 2.465, year: 2016

  15. /bar p/p collider physics

    International Nuclear Information System (INIS)

    Green, D.

    1989-03-01

    This note encompasses a set of six lectures given at the summer school held at Campos Do Jordao in January of 1989 near Sao Paulo, Brazil. The intent of the lectures was to describe the physics of /bar p/p at CERN and Fermilab. Particular attention has been paid to making a self contained presentation to a prospective audience of graduate students. Since large Monte Carlo codes might not be available to all members of this audience, great reliance was placed on ''back of the envelope estimates.'' Emphasis was also placed on experimental data rather than theoretical speculation, since predictions for, for example, supersymmetric particle production are easily obtained by transcription of formulae already obtained. 9 refs., 67 figs., 2 tabs

  16. The muscle-specific protein phosphatase PP1G/R(GL)(G(M))is essential for activation of glycogen synthase by exercise

    DEFF Research Database (Denmark)

    Aschenbach, W G; Suzuki, Y; Breeden, K

    2001-01-01

    In skeletal muscle both insulin and contractile activity are physiological stimuli for glycogen synthesis, which is thought to result in part from the dephosphorylation and activation of glycogen synthase (GS). PP1G/R(GL)(G(M)) is a glycogen/sarcoplasmic reticulum-associated type 1 phosphatase...... that was originally postulated to mediate insulin control of glycogen metabolism. However, we recently showed (Suzuki, Y., Lanner, C., Kim, J.-H., Vilardo, P. G., Zhang, H., Jie Yang, J., Cooper, L. D., Steele, M., Kennedy, A., Bock, C., Scrimgeour, A., Lawrence, J. C. Jr., L., and DePaoli-Roach, A. A. (2001) Mol....... Cell. Biol. 21, 2683-2694) that insulin activates GS in muscle of R(GL)(G(M)) knockout (KO) mice similarly to the wild type (WT). To determine whether PP1G is involved in glycogen metabolism during muscle contractions, R(GL) KO and overexpressors (OE) were subjected to two models of contraction...

  17. Mutational analysis of the pumpkin (Cucurbita maxima) phloem exudate lectin, PP2 reveals Ser-104 is crucial for carbohydrate binding.

    Science.gov (United States)

    Bobbili, Kishore Babu; Bandari, Shyam; Grobe, Kay; Swamy, Musti J

    2014-07-18

    The pumpkin phloem lectin (PP2) is an RNA-binding, defense-related, chitooligosaccharide-specific, homodimeric lectin of Mr 48 kDa expressed at high concentrations in the sieve elements and companion cells of pumpkin (Cucurbita maxima). In the present study, PP2 was expressed in the methylotrophic yeast Pichia pastoris with the Saccharomyces α-factor sequence to direct the recombinant protein into the secretory pathway as a prerequisite for unimpaired folding and posttranslational glycosylation of recombinant PP2. Previous computational modeling and ligand docking studies predicted a putative chitooligosaccharide-binding site on the PP2 surface, which was divided into three subsites, with two amino acid residues in each subsite identified as possible candidates for interaction with chitooligosaccharides (CHOs). In this work, mutational analysis and hemagglutination assays were employed to verify the role of the predicted residues in the carbohydrate binding activity of the protein. The results obtained revealed that mutation of Ser-104 to Ala (S104A) at subsite-2 resulted in about 90% loss of agglutination activity of the protein, indicating that Ser-104 is crucial for the binding of CHOs to PP2. Also, L100A (at subsite-1) and K200A (at subsite-3) independently decreased the lectin activity by about 40%, indicating that these two residues also contribute significantly to sugar binding by PP2. Together, these findings confirm that all the three subsites contribute to varying degrees toward PP2-carbohydrate interaction, and confirm the validity of the computational model, as proposed earlier. Copyright © 2014 Elsevier Inc. All rights reserved.

  18. Biodegradability of PP/HMSPP and natural and synthetic polymers blends in function of gamma irradiation degradation

    International Nuclear Information System (INIS)

    Cardoso, Elisabeth C.L.; Scagliusi, Sandra R.; Lima, Luis F.C.P.; Bueno, Nelson R.; Brant, Antonio J.C.; Parra, Duclerc F.; Lugão, Ademar B.

    2014-01-01

    Polymers are used for numerous applications in different industrial segments, generating enormous quantities of discarding in the environment. Polymeric materials composites account for an estimated from 20 to 30% total volume of solid waste. Polypropylene (PP) undergoes crosslinking and extensive main chain scissions when submitted to ionizing irradiation; as one of the most widely used linear hydrocarbon polymers, PP, made from cheap petrochemical feed stocks, shows easy processing leading it to a comprehensive list of finished products. Consequently, there is accumulation in the environment, at 25 million tons per year rate, since polymeric products are not easily consumed by microorganisms. PP polymers are very bio-resistant due to involvement of only carbon atoms in main chain with no hydrolysable functional group. Several possibilities have been considered to minimize the environmental impact caused by non-degradable plastics, subjecting them to: physical, chemical and biological degradation or combination of all these due to the presence of moisture, air, temperature, light, high energy radiation or microorganisms. There are three main classes of biodegradable polymers: synthetic polymers, natural polymers and blends of polymers in which one or more components are readily consumed by microorganisms. This work aims to biodegradability investigation of a PP/HMSPP (high melt strength polypropylene) blended with sugarcane bagasse, PHB (poly-hydroxy-butyrate) and PLA (poly-lactic acid), both synthetic polymers, at a 10% level, subjected to gamma radiation at 50, 100, 150 and 200 kGy doses. Characterization will comprise IR, DSC, TGA, OIT and Laboratory Soil Burial Test (LSBT). - Highlights: • Polymeric materials composites account for an estimated from 20 to 30% total volume of solid waste. • Landfills will not be enough for an estimated accumulation of 25 million tons per year of plastics. • Incorporation of natural/synthetic polymers in PP/HMSPP to reduce

  19. Humans make near-optimal adjustments of control to initial body configuration in vertical squat jumping

    NARCIS (Netherlands)

    Bobbert, M.F.; Casius, L.J.R.; Kistemaker, D.A.

    2013-01-01

    We investigated adjustments of control to initial posture in squat jumping. Eleven male subjects jumped from three initial postures: preferred initial posture (PP), a posture in which the trunk was rotated 18° more backward (BP) and a posture in which it was rotated 15° more forward (FP) than in PP.

  20. Measurement of the inclusive W and Z production cross sections in pp collisions at $ \\sqrt {s} = 7 $ TeV with the CMS experiment

    Energy Technology Data Exchange (ETDEWEB)

    Chatrchyan, Serguei; et al.

    2011-10-01

    A measurement of inclusive W and Z production cross sections in pp collisions at sqrt(s)=7 TeV is presented. The electron and muon decay channels are analyzed in a data sample collected with the CMS detector at the LHC and corresponding to an integrated luminosity of 36 inverse picobarns. The measured inclusive cross sections are sigma(pp-> WX) B(W-> l nu) = 10.30 +/- 0.02 (stat.) +/- 0.10 (syst.) +/- 0.10 (th.) +/- 0.41 (lumi.) nb and sigma(pp -> ZX) B(Z-> l^+l^-) = 0.974 +/- 0.007 (stat.) +/- 0.007 (syst.) +/- 0.018 (th.) +/- 0.039 (lumi.) nb, limited to the dilepton invariant mass range 60 to 120 GeV. The luminosity-independent cross section ratios are [sigma(pp->WX) B(W-> l nu)]/[sigma(pp-> ZX) B(Z->l^+l^-)] = 10.54 +/- 0.07 (stat.) +/- 0.08 (syst.) +/- 0.16 (th.) and [sigma(pp->W^+X) B(W^+ -> l^+nu)] / [sigma(pp->W^- X) B(W^- -> l^- nu)] = 1.421 +/- 0.006 (stat.) +/- 0.014 (syst.) +/- 0.029 (th.). The measured values agree with next-to-next-to-leading order QCD cross section calculations based on recent parton distribution functions.

  1. Measurement of the Inclusive W and Z Production Cross Sections in pp Collisions at $\\sqrt{s}$ = 7 TeV with the CMS experiment

    CERN Document Server

    Chatrchyan, Serguei; Sirunyan, Albert M; Tumasyan, Armen; Adam, Wolfgang; Bergauer, Thomas; Dragicevic, Marko; Erö, Janos; Fabjan, Christian; Friedl, Markus; Fruehwirth, Rudolf; Ghete, Vasile Mihai; Hammer, Josef; Haensel, Stephan; Hoch, Michael; Hörmann, Natascha; Hrubec, Josef; Jeitler, Manfred; Kiesenhofer, Wolfgang; Krammer, Manfred; Liko, Dietrich; Mikulec, Ivan; Pernicka, Manfred; Rahbaran, Babak; Rohringer, Herbert; Schöfbeck, Robert; Strauss, Josef; Taurok, Anton; Teischinger, Florian; Wagner, Philipp; Waltenberger, Wolfgang; Walzel, Gerhard; Widl, Edmund; Wulz, Claudia-Elisabeth; Mossolov, Vladimir; Shumeiko, Nikolai; Suarez Gonzalez, Juan; Bansal, Sunil; Benucci, Leonardo; De Wolf, Eddi A; Janssen, Xavier; Maes, Thomas; Mucibello, Luca; Ochesanu, Silvia; Roland, Benoit; Rougny, Romain; Selvaggi, Michele; Van Haevermaet, Hans; Van Mechelen, Pierre; Van Remortel, Nick; Blekman, Freya; Blyweert, Stijn; D'Hondt, Jorgen; Devroede, Olivier; Gonzalez Suarez, Rebeca; Kalogeropoulos, Alexis; Maes, Michael; Van Doninck, Walter; Van Mulders, Petra; Van Onsem, Gerrit Patrick; Villella, Ilaria; Charaf, Otman; Clerbaux, Barbara; De Lentdecker, Gilles; Dero, Vincent; Gay, Arnaud; Hammad, Gregory Habib; Hreus, Tomas; Marage, Pierre Edouard; Raval, Amita; Thomas, Laurent; Vander Velde, Catherine; Vanlaer, Pascal; Adler, Volker; Cimmino, Anna; Costantini, Silvia; Grunewald, Martin; Klein, Benjamin; Lellouch, Jérémie; Marinov, Andrey; Mccartin, Joseph; Ryckbosch, Dirk; Thyssen, Filip; Tytgat, Michael; Vanelderen, Lukas; Verwilligen, Piet; Walsh, Sinead; Zaganidis, Nicolas; Basegmez, Suzan; Bruno, Giacomo; Caudron, Julien; Ceard, Ludivine; Cortina Gil, Eduardo; De Favereau De Jeneret, Jerome; Delaere, Christophe; Favart, Denis; Giammanco, Andrea; Grégoire, Ghislain; Hollar, Jonathan; Lemaitre, Vincent; Liao, Junhui; Militaru, Otilia; Nuttens, Claude; Ovyn, Severine; Pagano, Davide; Pin, Arnaud; Piotrzkowski, Krzysztof; Schul, Nicolas; Beliy, Nikita; Caebergs, Thierry; Daubie, Evelyne; Alves, Gilvan; Brito, Lucas; De Jesus Damiao, Dilson; Pol, Maria Elena; Henrique Gomes E Souza, Moacyr; Aldá Júnior, Walter Luiz; Carvalho, Wagner; Melo Da Costa, Eliza; De Oliveira Martins, Carley; Fonseca De Souza, Sandro; Mundim, Luiz; Nogima, Helio; Oguri, Vitor; Prado Da Silva, Wanda Lucia; Santoro, Alberto; Silva Do Amaral, Sheila Mara; Sznajder, Andre; Bernardes, Cesar Augusto; De Almeida Dias, Flavia; Tomei, Thiago; De Moraes Gregores, Eduardo; Lagana, Caio; Da Cunha Marinho, Franciole; Mercadante, Pedro G; Novaes, Sergio F; Padula, Sandra; Darmenov, Nikolay; Genchev, Vladimir; Iaydjiev, Plamen; Piperov, Stefan; Rodozov, Mircho; Stoykova, Stefka; Sultanov, Georgi; Tcholakov, Vanio; Trayanov, Rumen; Dimitrov, Anton; Hadjiiska, Roumyana; Karadzhinova, Aneliya; Kozhuharov, Venelin; Litov, Leander; Mateev, Matey; Pavlov, Borislav; Petkov, Peicho; Bian, Jian-Guo; Chen, Guo-Ming; Chen, He-Sheng; Jiang, Chun-Hua; Liang, Dong; Liang, Song; Meng, Xiangwei; Tao, Junquan; Wang, Jian; Wang, Jian; Wang, Xianyou; Wang, Zheng; Xiao, Hong; Xu, Ming; Zang, Jingjing; Zhang, Zhen; Ban, Yong; Guo, Shuang; Guo, Yifei; Li, Wenbo; Mao, Yajun; Qian, Si-Jin; Teng, Haiyun; Zhu, Bo; Zou, Wei; Cabrera, Andrés; Gomez Moreno, Bernardo; Ocampo Rios, Alberto Andres; Osorio Oliveros, Andres Felipe; Sanabria, Juan Carlos; Godinovic, Nikola; Lelas, Damir; Lelas, Karlo; Plestina, Roko; Polic, Dunja; Puljak, Ivica; Antunovic, Zeljko; Dzelalija, Mile; Brigljevic, Vuko; Duric, Senka; Kadija, Kreso; Morovic, Srecko; Attikis, Alexandros; Galanti, Mario; Mousa, Jehad; Nicolaou, Charalambos; Ptochos, Fotios; Razis, Panos A; Finger, Miroslav; Finger Jr, Michael; Assran, Yasser; Ellithi Kamel, Ali; Khalil, Shaaban; Mahmoud, Mohammed; Hektor, Andi; Kadastik, Mario; Müntel, Mait; Raidal, Martti; Rebane, Liis; Tiko, Andres; Azzolini, Virginia; Eerola, Paula; Fedi, Giacomo; Czellar, Sandor; Härkönen, Jaakko; Heikkinen, Mika Aatos; Karimäki, Veikko; Kinnunen, Ritva; Kortelainen, Matti J; Lampén, Tapio; Lassila-Perini, Kati; Lehti, Sami; Lindén, Tomas; Luukka, Panja-Riina; Mäenpää, Teppo; Tuominen, Eija; Tuominiemi, Jorma; Tuovinen, Esa; Ungaro, Donatella; Wendland, Lauri; Banzuzi, Kukka; Karjalainen, Ahti; Korpela, Arja; Tuuva, Tuure; Sillou, Daniel; Besancon, Marc; Choudhury, Somnath; Dejardin, Marc; Denegri, Daniel; Fabbro, Bernard; Faure, Jean-Louis; Ferri, Federico; Ganjour, Serguei; Gentit, François-Xavier; Givernaud, Alain; Gras, Philippe; Hamel de Monchenault, Gautier; Jarry, Patrick; Locci, Elizabeth; Malcles, Julie; Marionneau, Matthieu; Millischer, Laurent; Rander, John; Rosowsky, André; Shreyber, Irina; Titov, Maksym; Verrecchia, Patrice; Baffioni, Stephanie; Beaudette, Florian; Benhabib, Lamia; Bianchini, Lorenzo; Bluj, Michal; Broutin, Clementine; Busson, Philippe; Charlot, Claude; Dahms, Torsten; Dobrzynski, Ludwik; Elgammal, Sherif; Granier de Cassagnac, Raphael; Haguenauer, Maurice; Miné, Philippe; Mironov, Camelia; Ochando, Christophe; Paganini, Pascal; Sabes, David; Salerno, Roberto; Sirois, Yves; Thiebaux, Christophe; Wyslouch, Bolek; Zabi, Alexandre; Agram, Jean-Laurent; Andrea, Jeremy; Bloch, Daniel; Bodin, David; Brom, Jean-Marie; Cardaci, Marco; Chabert, Eric Christian; Collard, Caroline; Conte, Eric; Drouhin, Frédéric; Ferro, Cristina; Fontaine, Jean-Charles; Gelé, Denis; Goerlach, Ulrich; Greder, Sebastien; Juillot, Pierre; Karim, Mehdi; Le Bihan, Anne-Catherine; Mikami, Yoshinari; Van Hove, Pierre; Fassi, Farida; Mercier, Damien; Baty, Clement; Beauceron, Stephanie; Beaupere, Nicolas; Bedjidian, Marc; Bondu, Olivier; Boudoul, Gaelle; Boumediene, Djamel; Brun, Hugues; Chasserat, Julien; Chierici, Roberto; Contardo, Didier; Depasse, Pierre; El Mamouni, Houmani; Fay, Jean; Gascon, Susan; Ille, Bernard; Kurca, Tibor; Le Grand, Thomas; Lethuillier, Morgan; Mirabito, Laurent; Perries, Stephane; Sordini, Viola; Tosi, Silvano; Tschudi, Yohann; Verdier, Patrice; Lomidze, David; Anagnostou, Georgios; Beranek, Sarah; Edelhoff, Matthias; Feld, Lutz; Heracleous, Natalie; Hindrichs, Otto; Jussen, Ruediger; Klein, Katja; Merz, Jennifer; Mohr, Niklas; Ostapchuk, Andrey; Perieanu, Adrian; Raupach, Frank; Sammet, Jan; Schael, Stefan; Sprenger, Daniel; Weber, Hendrik; Weber, Martin; Wittmer, Bruno; Ata, Metin; Dietz-Laursonn, Erik; Erdmann, Martin; Hebbeker, Thomas; Heidemann, Carsten; Hinzmann, Andreas; Hoepfner, Kerstin; Klimkovich, Tatsiana; Klingebiel, Dennis; Kreuzer, Peter; Lanske, Dankfried; Lingemann, Joschka; Magass, Carsten; Merschmeyer, Markus; Meyer, Arnd; Papacz, Paul; Pieta, Holger; Reithler, Hans; Schmitz, Stefan Antonius; Sonnenschein, Lars; Steggemann, Jan; Teyssier, Daniel; Bontenackels, Michael; Davids, Martina; Duda, Markus; Flügge, Günter; Geenen, Heiko; Giffels, Manuel; Haj Ahmad, Wael; Heydhausen, Dirk; Hoehle, Felix; Kargoll, Bastian; Kress, Thomas; Kuessel, Yvonne; Linn, Alexander; Nowack, Andreas; Perchalla, Lars; Pooth, Oliver; Rennefeld, Jörg; Sauerland, Philip; Stahl, Achim; Thomas, Maarten; Tornier, Daiske; Zoeller, Marc Henning; Aldaya Martin, Maria; Behrenhoff, Wolf; Behrens, Ulf; Bergholz, Matthias; Bethani, Agni; Borras, Kerstin; Cakir, Altan; Campbell, Alan; Castro, Elena; Dammann, Dirk; Eckerlin, Guenter; Eckstein, Doris; Flossdorf, Alexander; Flucke, Gero; Geiser, Achim; Hauk, Johannes; Jung, Hannes; Kasemann, Matthias; Katkov, Igor; Katsas, Panagiotis; Kleinwort, Claus; Kluge, Hannelies; Knutsson, Albert; Krämer, Mira; Krücker, Dirk; Kuznetsova, Ekaterina; Lange, Wolfgang; Lohmann, Wolfgang; Mankel, Rainer; Marienfeld, Markus; Melzer-Pellmann, Isabell-Alissandra; Meyer, Andreas Bernhard; Mnich, Joachim; Mussgiller, Andreas; Olzem, Jan; Petrukhin, Alexey; Pitzl, Daniel; Raspereza, Alexei; Rosin, Michele; Schmidt, Ringo; Schoerner-Sadenius, Thomas; Sen, Niladri; Spiridonov, Alexander; Stein, Matthias; Tomaszewska, Justyna; Walsh, Roberval; Wissing, Christoph; Autermann, Christian; Blobel, Volker; Bobrovskyi, Sergei; Draeger, Jula; Enderle, Holger; Gebbert, Ulla; Görner, Martin; Hermanns, Thomas; Kaschube, Kolja; Kaussen, Gordon; Kirschenmann, Henning; Klanner, Robert; Lange, Jörn; Mura, Benedikt; Naumann-Emme, Sebastian; Nowak, Friederike; Pietsch, Niklas; Sander, Christian; Schettler, Hannes; Schleper, Peter; Schlieckau, Eike; Schröder, Matthias; Schum, Torben; Stadie, Hartmut; Steinbrück, Georg; Thomsen, Jan; Barth, Christian; Bauer, Julia; Berger, Joram; Buege, Volker; Chwalek, Thorsten; De Boer, Wim; Dierlamm, Alexander; Dirkes, Guido; Feindt, Michael; Gruschke, Jasmin; Hackstein, Christoph; Hartmann, Frank; Heinrich, Michael; Held, Hauke; Hoffmann, Karl-Heinz; Honc, Simon; Komaragiri, Jyothsna Rani; Kuhr, Thomas; Martschei, Daniel; Mueller, Steffen; Müller, Thomas; Niegel, Martin; Oberst, Oliver; Oehler, Andreas; Ott, Jochen; Peiffer, Thomas; Quast, Gunter; Rabbertz, Klaus; Ratnikov, Fedor; Ratnikova, Natalia; Renz, Manuel; Saout, Christophe; Scheurer, Armin; Schieferdecker, Philipp; Schilling, Frank-Peter; Schott, Gregory; Simonis, Hans-Jürgen; Stober, Fred-Markus Helmut; Troendle, Daniel; Wagner-Kuhr, Jeannine; Weiler, Thomas; Zeise, Manuel; Zhukov, Valery; Ziebarth, Eva Barbara; Daskalakis, Georgios; Geralis, Theodoros; Kesisoglou, Stilianos; Kyriakis, Aristotelis; Loukas, Demetrios; Manolakos, Ioannis; Markou, Athanasios; Markou, Christos; Mavrommatis, Charalampos; Ntomari, Eleni; Petrakou, Eleni; Gouskos, Loukas; Mertzimekis, Theodoros; Panagiotou, Apostolos; Saoulidou, Niki; Stiliaris, Efstathios; Evangelou, Ioannis; Foudas, Costas; Kokkas, Panagiotis; Manthos, Nikolaos; Papadopoulos, Ioannis; Patras, Vaios; Triantis, Frixos A; Aranyi, Attila; Bencze, Gyorgy; Boldizsar, Laszlo; Hajdu, Csaba; Hidas, Pàl; Horvath, Dezso; Kapusi, Anita; Krajczar, Krisztian; Sikler, Ferenc; Veres, Gabor Istvan; Vesztergombi, Gyorgy; Beni, Noemi; Molnar, Jozsef; Palinkas, Jozsef; Szillasi, Zoltan; Veszpremi, Viktor; Raics, Peter; Trocsanyi, Zoltan Laszlo; Ujvari, Balazs; Beri, Suman Bala; Bhatnagar, Vipin; Dhingra, Nitish; Gupta, Ruchi; Jindal, Monika; Kaur, Manjit; Kohli, Jatinder Mohan; Mehta, Manuk Zubin; Nishu, Nishu; Saini, Lovedeep Kaur; Sharma, Archana; Singh, Anil; Singh, Jasbir; Singh, Supreet Pal; Ahuja, Sudha; Choudhary, Brajesh C; Gupta, Pooja; Jain, Sandhya; Kumar, Ashok; Kumar, Arun; Naimuddin, Md; Ranjan, Kirti; Shivpuri, Ram Krishen; Banerjee, Sunanda; Bhattacharya, Satyaki; Dutta, Suchandra; Gomber, Bhawna; Jain, Shilpi; Khurana, Raman; Sarkar, Subir; Choudhury, Rajani Kant; Dutta, Dipanwita; Kailas, Swaminathan; Kumar, Vineet; Mehta, Pourus; Mohanty, Ajit Kumar; Pant, Lalit Mohan; Shukla, Prashant; Aziz, Tariq; Guchait, Monoranjan; Gurtu, Atul; Maity, Manas; Majumder, Devdatta; Majumder, Gobinda; Mazumdar, Kajari; Mohanty, Gagan Bihari; Saha, Anirban; Sudhakar, Katta; Wickramage, Nadeesha; Banerjee, Sudeshna; Dugad, Shashikant; Mondal, Naba Kumar; Arfaei, Hessamaddin; Bakhshiansohi, Hamed; Etesami, Seyed Mohsen; Fahim, Ali; Hashemi, Majid; Hesari, Hoda; Jafari, Abideh; Khakzad, Mohsen; Mohammadi, Abdollah; Mohammadi Najafabadi, Mojtaba; Paktinat Mehdiabadi, Saeid; Safarzadeh, Batool; Zeinali, Maryam; Abbrescia, Marcello; Barbone, Lucia; Calabria, Cesare; Colaleo, Anna; Creanza, Donato; De Filippis, Nicola; De Palma, Mauro; Fiore, Luigi; Iaselli, Giuseppe; Lusito, Letizia; Maggi, Giorgio; Maggi, Marcello; Manna, Norman; Marangelli, Bartolomeo; My, Salvatore; Nuzzo, Salvatore; Pacifico, Nicola; Pierro, Giuseppe Antonio; Pompili, Alexis; Pugliese, Gabriella; Romano, Francesco; Roselli, Giuseppe; Selvaggi, Giovanna; Silvestris, Lucia; Trentadue, Raffaello; Tupputi, Salvatore; Zito, Giuseppe; Abbiendi, Giovanni; Benvenuti, Alberto; Bonacorsi, Daniele; Braibant-Giacomelli, Sylvie; Brigliadori, Luca; Capiluppi, Paolo; Castro, Andrea; Cavallo, Francesca Romana; Cuffiani, Marco; Dallavalle, Gaetano-Marco; Fabbri, Fabrizio; Fanfani, Alessandra; Fasanella, Daniele; Giacomelli, Paolo; Giunta, Marina; Grandi, Claudio; Marcellini, Stefano; Masetti, Gianni; Meneghelli, Marco; Montanari, Alessandro; Navarria, Francesco; Odorici, Fabrizio; Perrotta, Andrea; Primavera, Federica; Rossi, Antonio; Rovelli, Tiziano; Siroli, Gianni; Travaglini, Riccardo; Albergo, Sebastiano; Cappello, Gigi; Chiorboli, Massimiliano; Costa, Salvatore; Potenza, Renato; Tricomi, Alessia; Tuve, Cristina; Barbagli, Giuseppe; Ciulli, Vitaliano; Civinini, Carlo; D'Alessandro, Raffaello; Focardi, Ettore; Frosali, Simone; Gallo, Elisabetta; Gonzi, Sandro; Lenzi, Piergiulio; Meschini, Marco; Paoletti, Simone; Sguazzoni, Giacomo; Tropiano, Antonio; Benussi, Luigi; Bianco, Stefano; Colafranceschi, Stefano; Fabbri, Franco; Piccolo, Davide; Fabbricatore, Pasquale; Musenich, Riccardo; Benaglia, Andrea; De Guio, Federico; Di Matteo, Leonardo; Gennai, Simone; Ghezzi, Alessio; Malvezzi, Sandra; Martelli, Arabella; Massironi, Andrea; Menasce, Dario; Moroni, Luigi; Paganoni, Marco; Pedrini, Daniele; Ragazzi, Stefano; Redaelli, Nicola; Sala, Silvano; Tabarelli de Fatis, Tommaso; Buontempo, Salvatore; Carrillo Montoya, Camilo Andres; Cavallo, Nicola; De Cosa, Annapaola; Fabozzi, Francesco; Iorio, Alberto Orso Maria; Lista, Luca; Merola, Mario; Paolucci, Pierluigi; Azzi, Patrizia; Bacchetta, Nicola; Bellan, Paolo; Bisello, Dario; Branca, Antonio; Carlin, Roberto; Checchia, Paolo; Dorigo, Tommaso; Dosselli, Umberto; Fanzago, Federica; Gasparini, Fabrizio; Gasparini, Ugo; Gozzelino, Andrea; Lacaprara, Stefano; Lazzizzera, Ignazio; Margoni, Martino; Mazzucato, Mirco; Meneguzzo, Anna Teresa; Nespolo, Massimo; Perrozzi, Luca; Pozzobon, Nicola; Ronchese, Paolo; Simonetto, Franco; Torassa, Ezio; Tosi, Mia; Vanini, Sara; Zotto, Pierluigi; Zumerle, Gianni; Baesso, Paolo; Berzano, Umberto; Ratti, Sergio P; Riccardi, Cristina; Torre, Paola; Vitulo, Paolo; Viviani, Claudio; Biasini, Maurizio; Bilei, Gian Mario; Caponeri, Benedetta; Fanò, Livio; Lariccia, Paolo; Lucaroni, Andrea; Mantovani, Giancarlo; Menichelli, Mauro; Nappi, Aniello; Romeo, Francesco; Santocchia, Attilio; Taroni, Silvia; Valdata, Marisa; Azzurri, Paolo; Bagliesi, Giuseppe; Bernardini, Jacopo; Boccali, Tommaso; Broccolo, Giuseppe; Castaldi, Rino; D'Agnolo, Raffaele Tito; Dell'Orso, Roberto; Fiori, Francesco; Foà, Lorenzo; Giassi, Alessandro; Kraan, Aafke; Ligabue, Franco; Lomtadze, Teimuraz; Martini, Luca; Messineo, Alberto; Palla, Fabrizio; Palmonari, Francesco; Segneri, Gabriele; Serban, Alin Titus; Spagnolo, Paolo; Tenchini, Roberto; Tonelli, Guido; Venturi, Andrea; Verdini, Piero Giorgio; Barone, Luciano; Cavallari, Francesca; Del Re, Daniele; Di Marco, Emanuele; Diemoz, Marcella; Franci, Daniele; Grassi, Marco; Longo, Egidio; Meridiani, Paolo; Nourbakhsh, Shervin; Organtini, Giovanni; Pandolfi, Francesco; Paramatti, Riccardo; Rahatlou, Shahram; Rovelli, Chiara; Amapane, Nicola; Arcidiacono, Roberta; Argiro, Stefano; Arneodo, Michele; Biino, Cristina; Botta, Cristina; Cartiglia, Nicolo; Castello, Roberto; Costa, Marco; Demaria, Natale; Graziano, Alberto; Mariotti, Chiara; Marone, Matteo; Maselli, Silvia; Migliore, Ernesto; Mila, Giorgia; Monaco, Vincenzo; Musich, Marco; Obertino, Maria Margherita; Pastrone, Nadia; Pelliccioni, Mario; Potenza, Alberto; Romero, Alessandra; Ruspa, Marta; Sacchi, Roberto; Sola, Valentina; Solano, Ada; Staiano, Amedeo; Vilela Pereira, Antonio; Belforte, Stefano; Cossutti, Fabio; Della Ricca, Giuseppe; Gobbo, Benigno; Montanino, Damiana; Penzo, Aldo; Heo, Seong Gu; Nam, Soon-Kwon; Chang, Sunghyun; Chung, Jin Hyuk; Kim, Dong Hee; Kim, Gui Nyun; Kim, Ji Eun; Kong, Dae Jung; Park, Hyangkyu; Ro, Sang-Ryul; Son, Dong-Chul; Son, Taejin; Kim, Jaeho; Kim, Jae Yool; Song, Sanghyeon; Choi, Suyong; Hong, Byung-Sik; Jo, Mihee; Kim, Hyunchul; Kim, Ji Hyun; Kim, Tae Jeong; Lee, Kyong Sei; Moon, Dong Ho; Park, Sung Keun; Sim, Kwang Souk; Choi, Minkyoo; Kang, Seokon; Kim, Hyunyong; Park, Chawon; Park, Inkyu; Park, Sangnam; Ryu, Geonmo; Choi, Young-Il; Choi, Young Kyu; Goh, Junghwan; Kim, Min Suk; Lee, Byounghoon; Lee, Jongseok; Lee, Sungeun; Seo, Hyunkwan; Yu, Intae; Bilinskas, Mykolas Jurgis; Grigelionis, Ignas; Janulis, Mindaugas; Martisiute, Dalia; Petrov, Pavel; Polujanskas, Mindaugas; Sabonis, Tomas; Castilla-Valdez, Heriberto; De La Cruz-Burelo, Eduard; Heredia-de La Cruz, Ivan; Lopez-Fernandez, Ricardo; Magaña Villalba, Ricardo; Sánchez-Hernández, Alberto; Villasenor-Cendejas, Luis Manuel; Carrillo Moreno, Salvador; Vazquez Valencia, Fabiola; Salazar Ibarguen, Humberto Antonio; Casimiro Linares, Edgar; Morelos Pineda, Antonio; Reyes-Santos, Marco A; Krofcheck, David; Tam, Jason; Butler, Philip H; Doesburg, Robert; Silverwood, Hamish; Ahmad, Muhammad; Ahmed, Ijaz; Asghar, Muhammad Irfan; Hoorani, Hafeez R; Khan, Wajid Ali; Khurshid, Taimoor; Qazi, Shamona; Brona, Grzegorz; Cwiok, Mikolaj; Dominik, Wojciech; Doroba, Krzysztof; Kalinowski, Artur; Konecki, Marcin; Krolikowski, Jan; Frueboes, Tomasz; Gokieli, Ryszard; Górski, Maciej; Kazana, Malgorzata; Nawrocki, Krzysztof; Romanowska-Rybinska, Katarzyna; Szleper, Michal; Wrochna, Grzegorz; Zalewski, Piotr; Almeida, Nuno; Bargassa, Pedrame; David Tinoco Mendes, Andre; Faccioli, Pietro; Ferreira Parracho, Pedro Guilherme; Gallinaro, Michele; Musella, Pasquale; Nayak, Aruna; Pela, Joao; Ribeiro, Pedro Quinaz; Seixas, Joao; Varela, Joao; Afanasiev, Serguei; Belotelov, Ivan; Golutvin, Igor; Kamenev, Alexey; Karjavin, Vladimir; Kozlov, Guennady; Lanev, Alexander; Moisenz, Petr; Palichik, Vladimir; Perelygin, Victor; Savina, Maria; Shmatov, Sergey; Smirnov, Vitaly; Volodko, Anton; Zarubin, Anatoli; Golovtsov, Victor; Ivanov, Yury; Kim, Victor; Levchenko, Petr; Murzin, Victor; Oreshkin, Vadim; Smirnov, Igor; Sulimov, Valentin; Uvarov, Lev; Vavilov, Sergey; Vorobyev, Alexey; Vorobyev, Andrey; Andreev, Yuri; Dermenev, Alexander; Gninenko, Sergei; Golubev, Nikolai; Kirsanov, Mikhail; Krasnikov, Nikolai; Matveev, Viktor; Pashenkov, Anatoli; Toropin, Alexander; Troitsky, Sergey; Epshteyn, Vladimir; Gavrilov, Vladimir; Kaftanov, Vitali; Kossov, Mikhail; Krokhotin, Andrey; Lychkovskaya, Natalia; Popov, Vladimir; Safronov, Grigory; Semenov, Sergey; Stolin, Viatcheslav; Vlasov, Evgueni; Zhokin, Alexander; Belyaev, Andrey; Boos, Edouard; Dubinin, Mikhail; Dudko, Lev; Ershov, Alexander; Gribushin, Andrey; Kodolova, Olga; Lokhtin, Igor; Markina, Anastasia; Obraztsov, Stepan; Perfilov, Maxim; Petrushanko, Sergey; Sarycheva, Ludmila; Savrin, Viktor; Snigirev, Alexander; Andreev, Vladimir; Azarkin, Maksim; Dremin, Igor; Kirakosyan, Martin; Leonidov, Andrey; Rusakov, Sergey V; Vinogradov, Alexey; Azhgirey, Igor; Bayshev, Igor; Bitioukov, Sergei; Grishin, Viatcheslav; Kachanov, Vassili; Konstantinov, Dmitri; Korablev, Andrey; Krychkine, Victor; Petrov, Vladimir; Ryutin, Roman; Sobol, Andrei; Tourtchanovitch, Leonid; Troshin, Sergey; Tyurin, Nikolay; Uzunian, Andrey; Volkov, Alexey; Adzic, Petar; Djordjevic, Milos; Krpic, Dragomir; Milosevic, Jovan; Aguilar-Benitez, Manuel; Alcaraz Maestre, Juan; Arce, Pedro; Battilana, Carlo; Calvo, Enrique; Cepeda, Maria; Cerrada, Marcos; Chamizo Llatas, Maria; Colino, Nicanor; De La Cruz, Begona; Delgado Peris, Antonio; Diez Pardos, Carmen; Domínguez Vázquez, Daniel; Fernandez Bedoya, Cristina; Fernández Ramos, Juan Pablo; Ferrando, Antonio; Flix, Jose; Fouz, Maria Cruz; Garcia-Abia, Pablo; Gonzalez Lopez, Oscar; Goy Lopez, Silvia; Hernandez, Jose M; Josa, Maria Isabel; Merino, Gonzalo; Puerta Pelayo, Jesus; Redondo, Ignacio; Romero, Luciano; Santaolalla, Javier; Senghi Soares, Mara; Willmott, Carlos; Albajar, Carmen; Codispoti, Giuseppe; de Trocóniz, Jorge F; Cuevas, Javier; Fernandez Menendez, Javier; Folgueras, Santiago; Gonzalez Caballero, Isidro; Lloret Iglesias, Lara; Vizan Garcia, Jesus Manuel; Brochero Cifuentes, Javier Andres; Cabrillo, Iban Jose; Calderon, Alicia; Chuang, Shan-Huei; Duarte Campderros, Jordi; Felcini, Marta; Fernandez, Marcos; Gomez, Gervasio; Gonzalez Sanchez, Javier; Jorda, Clara; Lobelle Pardo, Patricia; Lopez Virto, Amparo; Marco, Jesus; Marco, Rafael; Martinez Rivero, Celso; Matorras, Francisco; Munoz Sanchez, Francisca Javiela; Piedra Gomez, Jonatan; Rodrigo, Teresa; Rodríguez-Marrero, Ana Yaiza; Ruiz-Jimeno, Alberto; Scodellaro, Luca; Sobron Sanudo, Mar; Vila, Ivan; Vilar Cortabitarte, Rocio; 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Kuo, Chia-Ming; Li, Syue-Wei; Lin, Willis; Liu, Zong-Kai; Lu, Yun-Ju; Mekterovic, Darko; Volpe, Roberta; Wu, Jing-Han; Yu, Shin-Shan; Bartalini, Paolo; Chang, Paoti; Chang, You-Hao; Chang, Yu-Wei; Chao, Yuan; Chen, Kai-Feng; Hou, George Wei-Shu; Hsiung, Yee; Kao, Kai-Yi; Lei, Yeong-Jyi; Lu, Rong-Shyang; Shiu, Jing-Ge; Tzeng, Yeng-Ming; Wang, Minzu; Adiguzel, Aytul; Bakirci, Mustafa Numan; Cerci, Salim; Dozen, Candan; Dumanoglu, Isa; Eskut, Eda; Girgis, Semiray; Gokbulut, Gul; Hos, Ilknur; Kangal, Evrim Ersin; Kayis Topaksu, Aysel; Onengut, Gulsen; Ozdemir, Kadri; Ozturk, Sertac; Polatoz, Ayse; Sogut, Kenan; Sunar Cerci, Deniz; Tali, Bayram; Topakli, Huseyin; Uzun, Dilber; Vergili, Latife Nukhet; Vergili, Mehmet; Akin, Ilina Vasileva; Aliev, Takhmasib; Bilin, Bugra; Bilmis, Selcuk; Deniz, Muhammed; Gamsizkan, Halil; Guler, Ali Murat; Ocalan, Kadir; Ozpineci, Altug; Serin, Meltem; Sever, Ramazan; Surat, Ugur Emrah; Yildirim, Eda; Zeyrek, Mehmet; Deliomeroglu, Mehmet; Demir, Durmus; Gülmez, Erhan; 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Guneratne Bryer, Arlo; Hall, Geoffrey; Hatherell, Zoe; Hays, Jonathan; Iles, Gregory; Jarvis, Martyn; Karapostoli, Georgia; Lyons, Louis; MacEvoy, Barry C; Magnan, Anne-Marie; Marrouche, Jad; Mathias, Bryn; Nandi, Robin; Nash, Jordan; Nikitenko, Alexander; Papageorgiou, Anastasios; Pesaresi, Mark; Petridis, Konstantinos; Pioppi, Michele; Raymond, David Mark; Rogerson, Samuel; Rompotis, Nikolaos; Rose, Andrew; Ryan, Matthew John; Seez, Christopher; Sharp, Peter; Sparrow, Alex; Tapper, Alexander; Tourneur, Stephane; Vazquez Acosta, Monica; Virdee, Tejinder; Wakefield, Stuart; Wardle, Nicholas; Wardrope, David; Whyntie, Tom; Barrett, Matthew; Chadwick, Matthew; Cole, Joanne; Hobson, Peter R; Khan, Akram; Kyberd, Paul; Leslie, Dawn; Martin, William; Reid, Ivan; Teodorescu, Liliana; Hatakeyama, Kenichi; Liu, Hongxuan; Henderson, Conor; Bose, Tulika; Carrera Jarrin, Edgar; Fantasia, Cory; Heister, Arno; St John, Jason; Lawson, Philip; Lazic, Dragoslav; Rohlf, James; Sperka, David; Sulak, Lawrence; 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Koay, Sue Ann; Kovalskyi, Dmytro; Krutelyov, Vyacheslav; Lowette, Steven; Mccoll, Nickolas; Pavlunin, Viktor; Rebassoo, Finn; Ribnik, Jacob; Richman, Jeffrey; Rossin, Roberto; Stuart, David; To, Wing; Vlimant, Jean-Roch; Apresyan, Artur; Bornheim, Adolf; Bunn, Julian; Chen, Yi; Gataullin, Marat; Ma, Yousi; Mott, Alexander; Newman, Harvey B; Rogan, Christopher; Shin, Kyoungha; Timciuc, Vladlen; Traczyk, Piotr; Veverka, Jan; Wilkinson, Richard; Yang, Yong; Zhu, Ren-Yuan; Akgun, Bora; Carroll, Ryan; Ferguson, Thomas; Iiyama, Yutaro; Jang, Dong Wook; Jun, Soon Yung; Liu, Yueh-Feng; Paulini, Manfred; Russ, James; Vogel, Helmut; Vorobiev, Igor; Cumalat, John Perry; Dinardo, Mauro Emanuele; Drell, Brian Robert; Edelmaier, Christopher; Ford, William T; Gaz, Alessandro; Heyburn, Bernadette; Luiggi Lopez, Eduardo; Nauenberg, Uriel; Smith, James; Stenson, Kevin; Ulmer, Keith; Wagner, Stephen Robert; Zang, Shi-Lei; Agostino, Lorenzo; Alexander, James; Chatterjee, Avishek; Eggert, Nicholas; Gibbons, Lawrence Kent; Heltsley, Brian; Henriksson, Kristofer; Hopkins, Walter; Khukhunaishvili, Aleko; Kreis, Benjamin; Nicolas Kaufman, Gala; Patterson, Juliet Ritchie; Puigh, Darren; Ryd, Anders; Saelim, Michael; Salvati, Emmanuele; Shi, Xin; Sun, Werner; Teo, Wee Don; Thom, Julia; Thompson, Joshua; Vaughan, Jennifer; Weng, Yao; Winstrom, Lucas; Wittich, Peter; Biselli, Angela; Cirino, Guy; Winn, Dave; Abdullin, Salavat; Albrow, Michael; Anderson, Jacob; Apollinari, Giorgio; Atac, Muzaffer; Bakken, Jon Alan; Bauerdick, Lothar AT; Beretvas, Andrew; Berryhill, Jeffrey; Bhat, Pushpalatha C; Bloch, Ingo; Borcherding, Frederick; Burkett, Kevin; Butler, Joel Nathan; Chetluru, Vasundhara; Cheung, Harry; Chlebana, Frank; Cihangir, Selcuk; Cooper, William; Eartly, David P; Elvira, Victor Daniel; Esen, Selda; Fisk, Ian; Freeman, Jim; Gao, Yanyan; Gottschalk, Erik; Green, Dan; Gunthoti, Kranti; Gutsche, Oliver; Hanlon, Jim; Harris, Robert M; Hirschauer, James; Hooberman, Benjamin; Jensen, Hans; Johnson, Marvin; Joshi, Umesh; 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Low, Jia Fu; Matchev, Konstantin; Mitselmakher, Guenakh; Muniz, Lana; Prescott, Craig; Remington, Ronald; Rinkevicius, Aurelijus; Schmitt, Michael Houston; Scurlock, Bobby; Sellers, Paul; Skhirtladze, Nikoloz; Snowball, Matthew; Wang, Dayong; Yelton, John; Zakaria, Mohammed; Gaultney, Vanessa; Lebolo, Luis Miguel; Linn, Stephan; Markowitz, Pete; Martinez, German; Rodriguez, Jorge Luis; Adams, Todd; Askew, Andrew; Bochenek, Joseph; Chen, Jie; Diamond, Brendan; Gleyzer, Sergei V; Haas, Jeff; Hagopian, Sharon; Hagopian, Vasken; Jenkins, Merrill; Johnson, Kurtis F; Prosper, Harrison; Quertenmont, Loic; Sekmen, Sezen; Veeraraghavan, Venkatesh; Baarmand, Marc M; Dorney, Brian; Guragain, Samir; Hohlmann, Marcus; Kalakhety, Himali; Vodopiyanov, Igor; Adams, Mark Raymond; Anghel, Ioana Maria; Apanasevich, Leonard; Bai, Yuting; Bazterra, Victor Eduardo; Betts, Russell Richard; Callner, Jeremy; Cavanaugh, Richard; Dragoiu, Cosmin; Gauthier, Lucie; Gerber, Cecilia Elena; Hofman, David Jonathan; Khalatyan, Samvel; 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Yazgan, Efe; Appelt, Eric; Brownson, Eric; Engh, Daniel; Florez, Carlos; Gabella, William; Issah, Michael; Johns, Willard; Kurt, Pelin; Maguire, Charles; Melo, Andrew; Sheldon, Paul; Snook, Benjamin; Tuo, Shengquan; Velkovska, Julia; Arenton, Michael Wayne; Balazs, Michael; Boutle, Sarah; Cox, Bradley; Francis, Brian; Goodell, Joseph; Hirosky, Robert; Ledovskoy, Alexander; Lin, Chuanzhe; Neu, Christopher; Yohay, Rachel; Gollapinni, Sowjanya; Harr, Robert; Karchin, Paul Edmund; Lamichhane, Pramod; Mattson, Mark; Milstène, Caroline; Sakharov, Alexandre; Anderson, Michael; Bachtis, Michail; Bellinger, James Nugent; Carlsmith, Duncan; Dasu, Sridhara; Efron, Jonathan; Gray, Lindsey; Grogg, Kira Suzanne; Grothe, Monika; Hall-Wilton, Richard; Herndon, Matthew; Hervé, Alain; Klabbers, Pamela; Klukas, Jeffrey; Lanaro, Armando; Lazaridis, Christos; Leonard, Jessica; Loveless, Richard; Mohapatra, Ajit; Ojalvo, Isabel; Reeder, Don; Ross, Ian; Savin, Alexander; Smith, Wesley H; Swanson, Joshua; Weinberg, Marc

    2011-01-01

    A measurement of inclusive W and Z production cross sections in pp collisions at sqrt(s)=7 TeV is presented. The electron and muon decay channels are analyzed in a data sample collected with the CMS detector at the LHC and corresponding to an integrated luminosity of 36 inverse picobarns. The measured inclusive cross sections are sigma(pp-> WX) B(W-> l nu) = 10.30 +/- 0.02 (stat.) +/- 0.10 (syst.) +/- 0.10 (th.) +/- 0.41 (lumi.) nb and sigma(pp -> ZX) B(Z-> l^+l^-) = 0.974 +/- 0.007 (stat.) +/- 0.007 (syst.) +/- 0.018 (th.) +/- 0.039 (lumi.) nb, limited to the dilepton invariant mass range 60 to 120 GeV. The luminosity-independent cross section ratios are [sigma(pp->WX) B(W-> l nu)]/[sigma(pp-> ZX) B(Z->l^+l^-)] = 10.54 +/- 0.07 (stat.) +/- 0.08 (syst.) +/- 0.16 (th.) and [sigma(pp->W^+X) B(W^+ -> l^+nu)] / [sigma(pp->W^- X) +B(W^- -> l^- nu)] = 1.421 +/- 0.006 (stat.) +/- 0.014 (syst.) +/- 0.029 (th.). -> The measured values agree with next-to-next-to-leading order QCD cross section calculations based on r...

  2. Study of vector pvector N → {pp}{sub s}π reactions in the near-threshold region at ANKE-COSY

    Energy Technology Data Exchange (ETDEWEB)

    Dymov, Sergey [FZ-Juelich, Wilhelm-Johnen-Strasse 52428 Juelich (Germany); Collaboration: ANKE-Collaboration

    2014-07-01

    For description of pion reactions within the χPT framework it is important to establish that the same short-range NN → NNπ vertex contributes to both p-wave pion production, where both initial and final NN pairs are in S waves, and to other low energy phenomena. The COSY-ANKE collaboration has embarked on an ambitious program of performing a complete set of measurements of the NN → {pp}{sub s}π reactions so that a full amplitude analysis can be carried out. By selecting events with excitation energy in the proton-proton system E{sub pp} < 3 MeV, the resulting diproton {pp}{sub s} is overwhelmingly in the {sup 1}S{sub 0} state. As parts of this program, measurements at T{sub p} = 353 MeV of the cross sections dσ/dΩ and proton analyzing powers A{sub y}{sup p} in thevector pp → {pp}{sub s}π{sup 0} and the quasi-free vector pn → {pp}{sub s}π{sup -} reactions were done at ANKE, as well as of the transverse spin correlations A{sub x,x} and A{sub y,y} in the vector nvector p → {pp}{sub s}π{sup -} reaction. The partial wave analysis results in three distinct solutions that can all describe reasonably well the measured values. However, the predictions for A{sub x,z} are radically different. Hence even a low statistics measurement of this parameter would be sufficient to resolve the ambiguities. For a proton beam this can be achieved through the use of a Siberian snake. It is planned that such an experiment will be carried out at ANKE using the polarized deuterium target.

  3. Study of polypropylene irradiation to ensure the control of its environmental degradation; Estudo da irradiação do polipropileno para possibilitar o controle de sua degradação ambiental

    Energy Technology Data Exchange (ETDEWEB)

    Romano, Rebeca da Silva Grecco

    2017-07-01

    UV light, heat, and pollutants can interact with Polypropylene (PP) molecules, mainly with the tertiary carbon producing free radicals which can react with oxygen producing changes in its properties. PP has outstanding chemical and physical properties and a good processability at very low market price. In addition, PP is extensively used for manufacturing various kinds of products, however due to its large-scale consumption a lot of waste is generated at the end of their life cycle to the environment with low rate degradation. Controlled degradation of PP can be achieved by exposing the polymers to well defined parameters, such as absorbed dose, intemperies, oxygen, etc. In this study, structural changes in PP macro-molecule are created upon exposure to ionizing radiation such as: main chain scission, crosslinking and peroxidation (in presence of air). This study has the objective of comparing the environmental and accelerated exposures of PP neat, PP irradiated with 12,5 kGy and 20 kGy and the incorporation of the commercial pro-degradant d2w®. Dumbbell samples were manufactured by injection molding and exposed to the environment during 180 days and to accelerated aging to 192 days. The samples were characterized by Mechanical Testing, Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), X-ray Diffraction (DRX) and Differential Scanning Calorimetry (DSC). The samples previously irradiated, PP 20 kGy, after environmental aging showed higher oxidation and presence of surface cracks than the PP d2w® and PP neat. They also showed presence of carbonyl groups, decreases in elongation at break, increase in Strength Modulus and decrease of melting temperature corroborating with degradation. (author)

  4. Exotic events at the pp-bar collider: an excited quark or an excited colored boson

    International Nuclear Information System (INIS)

    Gershtein, S.S.; Jickia, G.V.; Pirogov, Y.F.

    1984-01-01

    We show that the exotic events with large missing transverse momentum (up to 80--90 GeV/c) observed at the pp-bar collider at CERN require by their signature and effective cross section the existence of an object with a mass of about 180 GeV/c 2 , which is produced like a resonance from the constituents of the hardronic beams and is capable of decaying into a W-jet and a Z-jet. An excited quark q*, produced like a resonance in qg collisions and decaying into Wq and Zq, is the best candidate for such a object. However, colored W* and Z* bosons, produced in qq-bar collisions and decaying into Wg and Zg, cannot be excluded. We discuss possible experiments at pp-bar, pp, and ep colliders for verifying the hypothesis of the excited quark and for investigating its properties

  5. Analysis of Υ production in pp collisions at 7 TeV with the ALICE muon spectrometer

    International Nuclear Information System (INIS)

    Ahn, S.U.

    2011-12-01

    The ALICE experiment is a general-purpose detector designed to study the Quark-Gluon Plasma (QGP) in heavy-ion collisions at CERN LHC. One of powerful probe to the QGP is the heavy quarkonium production in heavy-ion collisions compared to the pp collisions. The interests of the heavy quarkonium production is not limited in heavy-ion physics since its production mechanism in pp collisions is still ambiguous. The aim of this thesis work is to estimate the production cross section of Υ(nS) in pp collisions at √(s)= 7 TeV in their muon decay channel with the ALICE muon spectrometer. The ALICE muon spectrometer is located at the forward rapidity region -4 + μ - ] = [0.62±0.38(stat.)+0.12-0.21(syst.)] nb per rapidity unit. (author)

  6. Long-range correlations in high multiplicity pp and pA collisions

    Indian Academy of Sciences (India)

    2015-05-06

    May 6, 2015 ... relativistic nucleus–nucleus collisions, provide a unique window into ... correlations reflect the initial event-by-event collision geometry [7–12]. ..... reminiscent of pp jet-like correlations, and an event-activity-dependent part that ...

  7. Using the 4 Pillars™ Practice Transformation Program to increase adult Tdap immunization in a randomized controlled cluster trial.

    Science.gov (United States)

    Nowalk, Mary Patricia; Lin, Chyongchiou J; Pavlik, Valory N; Brown, Anthony E; Zhang, Song; Moehling, Krissy K; Raviotta, Jonathan M; South-Paul, Jeannette E; Hawk, Mary; Ricci, Edmund M; Middleton, Donald B; Patel, Suchita A; Ahmed, Faruque; Zimmerman, Richard K

    2016-09-22

    National adult Tdap vaccination rates are low, reinforcing the need to increase vaccination efforts in primary care offices. The 4 Pillars™ Practice Transformation Program is an evidence-based, step-by-step guide to improving primary care adult vaccination with an online implementation tracking dashboard. This study tested the effectiveness of an intervention to increase adult Tdap vaccination that included the 4 Pillars™ Program, provider education, and one-on-one coaching of practice-based immunization champions. 25 primary care practices participated in a randomized controlled cluster trial (RCCT) in Year 1 (6/1/2013-5/31/2014) and a pre-post study in Year 2 (6/1/2014-1/31/2015). Baseline year was 6/1/2012-5/31/2013, with data analyzed in 2016. Demographic and vaccination data were derived from de-identified electronic medical record (EMR) extractions. The primary outcomes were vaccination rates and percentage point (PP) changes/year. The cohort consisted of 70,549 patients ⩾18years who were seen in the practices ⩾1 time each year, with a baseline mean age=55years; 35% were men; 56% were non-white; 35% were Hispanic and 20% were on Medicare. Baseline vaccination rate averaged 35%. In the Year 1 RCCT, cumulative Tdap vaccination increased significantly in both intervention and control groups; in both cities, the percentage point increases in the intervention groups (7.7 PP in Pittsburgh and 9.9 PP in Houston) were significantly higher (P<0.001) than in the control groups (6.4 PP in Pittsburgh and 7.6 PP in Houston). In the Year 2 pre-post study, in both cities, active intervention groups increased rates significantly more (6.2 PP for both) than maintenance groups (2.2 PP in Pittsburgh and 4.1 PP in Houston; P<0.001). An intervention that includes the 4 Pillars™ Practice Transformation Program, staff education and coaching is effective for increasing adult Tdap immunization rates within primary care practices. Clinical Trial Registry Name/Number: NCT

  8. Multiplicity dependence of identified hadron production in pp collisions at √s = 7 TeV in the ALICE at LHC

    International Nuclear Information System (INIS)

    Nayak, Kishora

    2016-01-01

    Recent measurements in proton-lead (p-Pb) and high-multiplicity proton-proton (pp) collisions show some collective features that are similar to those observed in Pb-Pb collisions. We report the production of charged light flavour, strange and multi-strange hadrons (π; K; p; Λ; Ξ; Ω) at mid rapidity as a function of event multiplicity in pp collisions at √s = 7 TeV using the ALICE detectors. In the p_T -differential baryon to meson ratios (p/π; Λ/K"0_s), an enhancement of baryon production at intermediate p_T is observed in high-multiplicity pp collisions. This behavior is qualitatively similar to earlier measurements performed in p-Pb and Pb-Pb collisions as a function of event activity. The production rate of strange and multi-strange hadrons relative to pions exhibits a significant increase with multiplicity in the smaller colliding systems of pp and p-Pb, pointing to similar mechanisms at play in pp and p-Pb collisions. The results are also compared with QCD inspired model calculations. (author)

  9. Investigation of the cofactor controlled substrate specificity of yeast inorganic pyrophosphatase

    International Nuclear Information System (INIS)

    Dunaway-Mariano, D.; Barry, R.J.; Brush, T.; Ting, S.J.

    1986-01-01

    The PPase reaction requires the participation of three metal ion cofactors. One metal ion binds to PP activating it for reaction and the other two bind to the enzyme activating it for catalysis. Of the metal ions tested only Mg 2+ , Zn 2+ , Co 2+ , Mn 2+ can perform all these roles. Most trivalent metal ions can function to activate the PP for reaction but cannot activate the enzyme for catalysis. The Mg 2+ activated enzyme is specific for M-PP and M-PPS complexes while the Zn 2+ activated enzyme also acts on metal complexes of PPP, PPPOR, PPOR and PPF. 18 O-Incorporation studies show that the substituted phosphoryl group of the unsymmetrical PP complexes always serves as the leaving group. To gain insight into the mechanism of the cofactor control over the substrate specificity the order of substrate/cofactor binding to the enzyme was examined. Dead end inhibition studies in which Cr(III)PP served as substrate and Mg 2+ as cofactor indicate that the mechanism is rapid equilibrium ordered (CrPP binds first) while dead end inhibitor induced activator inhibition studies with Mg 2+ and MgPP indicate that the kinetic mechanism is steady state preferred order. Cofactor-enzyme binding was studied as a function of substrate structure and the results obtained rule out interference of Mg 2+ binding by substrate analogs as an explanation for the different substrate specificities of the Zn 2+ and Mg 2+ activated enzymes

  10. Deep-elastic pp scattering at LHCf rom low-x gluons

    Czech Academy of Sciences Publication Activity Database

    Islam, M.M.; Kašpar, Jan; Luddy, R.J.

    2009-01-01

    Roč. 24, č. 7 (2009), s. 485-496 ISSN 0217-7323 R&D Projects: GA MŠk LA08015 Institutional research plan: CEZ:AV0Z10100502 Keywords : elastic pp scattering * LHC Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 1.075, year: 2009

  11. The search for rare decays of B mesons at the anti-pp colliders

    International Nuclear Information System (INIS)

    Quareni Vignudelli, A.; Bocciolini, M.; Conti, A.; Di Caporiacco, G.; Meschini, M.; Parrini, G.; Cline, D.; Rhoades, J.

    1988-01-01

    The UA1 group has reported a large B-barB production cross-section at Santi-ppS energies (∼ 1 μb). Following this observation it is indicated how the large rate of B mesons produced in anti-pp collisions could be used to search for and detect various rate decays. Several specific decays and the theoretical expectations and implications of the detections of these decays have been considered. Tests of the GIM model, horizontal symmetry and CP violation can be carried out in this manner. A spectrometer consisting of a CCD telescope, a magnetized muon detection spectrometer and an e.m. shower detector is described

  12. Figure of merit comparison of PP-based electret and PVDF-based piezoelectric polymer energy harvesters

    Science.gov (United States)

    Mrlík, M.; Leadenham, S.; AlMaadeed, M. A.; Erturk, A.

    2016-04-01

    The harvesting of mechanical strain and kinetic energy has received great attention over the past two decades in order to power wireless electronic components such as those used in passive and active monitoring applications. Piezoelectric ceramics, such as PZT (lead zirconate titanate), constitute the most commonly used electromechanical interface in vibration energy harvesters. However, there are applications in which piezoelectric ceramics cannot be used due to their low allowable curvature and brittle nature. Soft polymer PVDF (polyvinylidene fluoride) is arguably the most popular non-ceramic soft piezoelectric energy harvester material for such scenarios. Another type of polymer that has received less attention is PP (polypropylene) for electret-based energy harvesting using the thickness mode (33- mode). This work presents figure of merit comparison of PP versus PVDF for off-resonant energy harvesting in thickness mode operation, revealing substantial advantage of PP over PVDF. For thickness mode energy harvesting scenarios (e.g. dynamic compression) at reasonable ambient vibration frequencies, the figure of merit for the maximum power output is proportional to the square of the effective piezoelectric strain constant divided by the effective permittivity constant. Under optimal conditions and for the same volume, it is shown that PP can generate more than two orders of magnitude larger electrical power as compared to PVDF due to the larger effective piezoelectric strain constant and lower permittivity of the former.

  13. Annual Conference on Manual Control (20th) Held in California on June 12 - 14, 1984. Volume 1

    Science.gov (United States)

    1984-06-14

    Semisupine Pilot", Avimtion Space and Environmental Medicine , vol. 49, No. 1, pp. 304-317, January, 1978. [5] Levison, W.H., "Model For Human Controller...Performance in Vibration Environment", Aviation Space and Environmental Medicine , vol. 49, No. 1, pp. 321-327, January, 1978. [6] Repperger, D. W...Schwartz, Anthony C. Stein, Raymond E. Magdaleno, and Jeffrey R. Hogue, Effects of Alcohol and Marihuana on Driver Control Behavior. Volume I: Laboratory

  14. Characterization of ppGalNAc-T18, a member of the vertebrate-specific Y subfamily of UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases.

    Science.gov (United States)

    Li, Xing; Wang, Jing; Li, Wei; Xu, Yingjiao; Shao, Dong; Xie, Yinyin; Xie, Wenxian; Kubota, Tomomi; Narimatsu, Hisashi; Zhang, Yan

    2012-05-01

    The first step of mucin-type O-glycosylation is catalyzed by members of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-T; EC 2.4.1.41) family. Each member of this family has unique substrate specificity and expression profiles. In this report, we describe a new subfamily of ppGalNAc-Ts, designated the Y subfamily. The Y subfamily consists of four members, ppGalNAc-T8, -T9, -T17 and -T18, in which the conserved YDX(5)WGGENXE sequence in the Gal/GalNAc-T motif of ppGalNAc-Ts is mutated to LDX(5)YGGENXE. Phylogenetic analysis revealed that the Y subfamily members only exist in vertebrates. All four Y subfamily members lack in vitro GalNAc-transferase activity toward classical substrates possibly because of the UDP-GalNAc-binding pocket mutants. However, ppGalNAc-T18, the newly identified defining member, was localized in the endoplasmic reticulum rather than the Golgi apparatus in lung carcinoma cells. The knockdown of ppGalNAc-T18 altered cell morphology, proliferation potential and changed cell O-glycosylation. ppGalNAc-T18 can also modulate the in vitro GalNAc-transferase activity of ppGalNAc-T2 and -T10, suggesting that it may be a chaperone-like protein. These findings suggest that the new Y subfamily of ppGalNAc-Ts plays an important role in protein glycosylation; characterizing their functions will provide new insight into the role of ppGalNAc-Ts.

  15. Measurement of $\\Upsilon$ production in $pp$ collisions at $\\sqrt{s}=2.76$ TeV

    CERN Document Server

    Aaij, Roel; Adinolfi, Marco; Affolder, Anthony; Ajaltouni, Ziad; Albrecht, Johannes; Alessio, Federico; Alexander, Michael; Ali, Suvayu; Alkhazov, Georgy; Alvarez Cartelle, Paula; Alves Jr, Antonio; Amato, Sandra; Amerio, Silvia; Amhis, Yasmine; Anderlini, Lucio; Anderson, Jonathan; Andreassen, Rolf; Andreotti, Mirco; Andrews, Jason; Appleby, Robert; Aquines Gutierrez, Osvaldo; Archilli, Flavio; Artamonov, Alexander; Artuso, Marina; Aslanides, Elie; Auriemma, Giulio; Baalouch, Marouen; Bachmann, Sebastian; Back, John; Badalov, Alexey; Balagura, Vladislav; Baldini, Wander; Barlow, Roger; Barschel, Colin; Barsuk, Sergey; Barter, William; Batozskaya, Varvara; Bauer, Thomas; Bay, Aurelio; Beddow, John; Bedeschi, Franco; Bediaga, Ignacio; Belogurov, Sergey; Belous, Konstantin; Belyaev, Ivan; Ben-Haim, Eli; Bencivenni, Giovanni; Benson, Sean; Benton, Jack; Berezhnoy, Alexander; Bernet, Roland; Bettler, Marc-Olivier; van Beuzekom, Martinus; Bien, Alexander; Bifani, Simone; Bird, Thomas; Bizzeti, Andrea; Bjørnstad, Pål Marius; Blake, Thomas; Blanc, Frédéric; Blouw, Johan; Blusk, Steven; Bocci, Valerio; Bondar, Alexander; Bondar, Nikolay; Bonivento, Walter; Borghi, Silvia; Borgia, Alessandra; Borsato, Martino; Bowcock, Themistocles; Bowen, Espen Eie; Bozzi, Concezio; Brambach, Tobias; van den Brand, Johannes; Bressieux, Joël; Brett, David; Britsch, Markward; Britton, Thomas; Brook, Nicholas; Brown, Henry; Bursche, Albert; Busetto, Giovanni; Buytaert, Jan; Cadeddu, Sandro; Calabrese, Roberto; Callot, Olivier; Calvi, Marta; Calvo Gomez, Miriam; Camboni, Alessandro; Campana, Pierluigi; Campora Perez, Daniel; Carbone, Angelo; Carboni, Giovanni; Cardinale, Roberta; Cardini, Alessandro; Carranza-Mejia, Hector; Carson, Laurence; Carvalho Akiba, Kazuyoshi; Casse, Gianluigi; Castillo Garcia, Lucia; Cattaneo, Marco; Cauet, Christophe; Cenci, Riccardo; Charles, Matthew; Charpentier, Philippe; Cheung, Shu-Faye; Chiapolini, Nicola; Chrzaszcz, Marcin; Ciba, Krzystof; Cid Vidal, Xabier; Ciezarek, Gregory; Clarke, Peter; Clemencic, Marco; Cliff, Harry; Closier, Joel; Coca, Cornelia; Coco, Victor; Cogan, Julien; Cogneras, Eric; Collins, Paula; Comerma-Montells, Albert; Contu, Andrea; Cook, Andrew; Coombes, Matthew; Coquereau, Samuel; Corti, Gloria; Counts, Ian; Couturier, Benjamin; Cowan, Greig; Craik, Daniel Charles; Cruz Torres, Melissa Maria; Cunliffe, Samuel; Currie, Robert; D'Ambrosio, Carmelo; Dalseno, Jeremy; David, Pascal; David, Pieter; Davis, Adam; De Bonis, Isabelle; De Bruyn, Kristof; De Capua, Stefano; De Cian, Michel; De Miranda, Jussara; De Paula, Leandro; De Silva, Weeraddana; De Simone, Patrizia; Decamp, Daniel; Deckenhoff, Mirko; Del Buono, Luigi; Déléage, Nicolas; Derkach, Denis; Deschamps, Olivier; Dettori, Francesco; Di Canto, Angelo; Dijkstra, Hans; Donleavy, Stephanie; Dordei, Francesca; Dorigo, Mirco; Dorosz, Piotr; Dosil Suárez, Alvaro; Dossett, David; Dovbnya, Anatoliy; Dupertuis, Frederic; Durante, Paolo; Dzhelyadin, Rustem; Dziurda, Agnieszka; Dzyuba, Alexey; Easo, Sajan; Egede, Ulrik; Egorychev, Victor; Eidelman, Semen; Eisenhardt, Stephan; Eitschberger, Ulrich; Ekelhof, Robert; Eklund, Lars; El Rifai, Ibrahim; Elsasser, Christian; Esen, Sevda; Falabella, Antonio; Färber, Christian; Farinelli, Chiara; Farry, Stephen; Ferguson, Dianne; Fernandez Albor, Victor; Ferreira Rodrigues, Fernando; Ferro-Luzzi, Massimiliano; Filippov, Sergey; Fiore, Marco; Fiorini, Massimiliano; Fitzpatrick, Conor; Fontana, Marianna; Fontanelli, Flavio; Forty, Roger; Francisco, Oscar; Frank, Markus; Frei, Christoph; Frosini, Maddalena; Fu, Jinlin; Furfaro, Emiliano; Gallas Torreira, Abraham; Galli, Domenico; Gandelman, Miriam; Gandini, Paolo; Gao, Yuanning; Garofoli, Justin; Garra Tico, Jordi; Garrido, Lluis; Gaspar, Clara; Gauld, Rhorry; Gersabeck, Evelina; Gersabeck, Marco; Gershon, Timothy; Ghez, Philippe; Gianelle, Alessio; Giani', Sebastiana; Gibson, Valerie; Giubega, Lavinia-Helena; Gligorov, Vladimir; Göbel, Carla; Golubkov, Dmitry; Golutvin, Andrey; Gomes, Alvaro; Gordon, Hamish; Grabalosa Gándara, Marc; Graciani Diaz, Ricardo; Granado Cardoso, Luis Alberto; Graugés, Eugeni; Graziani, Giacomo; Grecu, Alexandru; Greening, Edward; Gregson, Sam; Griffith, Peter; Grillo, Lucia; Grünberg, Oliver; Gui, Bin; Gushchin, Evgeny; Guz, Yury; Gys, Thierry; Hadjivasiliou, Christos; Haefeli, Guido; Haen, Christophe; Hafkenscheid, Tom; Haines, Susan; Hall, Samuel; Hamilton, Brian; Hampson, Thomas; Hansmann-Menzemer, Stephanie; Harnew, Neville; Harnew, Samuel; Harrison, Jonathan; Hartmann, Thomas; He, Jibo; Head, Timothy; Heijne, Veerle; Hennessy, Karol; Henrard, Pierre; Henry, Louis; Hernando Morata, Jose Angel; van Herwijnen, Eric; Heß, Miriam; Hicheur, Adlène; Hill, Donal; Hoballah, Mostafa; Hombach, Christoph; Hulsbergen, Wouter; Hunt, Philip; Hussain, Nazim; Hutchcroft, David; Hynds, Daniel; Iakovenko, Viktor; Idzik, Marek; Ilten, Philip; Jacobsson, Richard; Jaeger, Andreas; Jans, Eddy; Jaton, Pierre; Jawahery, Abolhassan; Jing, Fanfan; John, Malcolm; Johnson, Daniel; Jones, Christopher; Joram, Christian; Jost, Beat; Jurik, Nathan; Kaballo, Michael; Kandybei, Sergii; Kanso, Wallaa; Karacson, Matthias; Karbach, Moritz; Kelsey, Matthew; Kenyon, Ian; Ketel, Tjeerd; Khanji, Basem; Khurewathanakul, Chitsanu; Klaver, Suzanne; Kochebina, Olga; Komarov, Ilya; Koopman, Rose; Koppenburg, Patrick; Korolev, Mikhail; Kozlinskiy, Alexandr; Kravchuk, Leonid; Kreplin, Katharina; Kreps, Michal; Krocker, Georg; Krokovny, Pavel; Kruse, Florian; Kucharczyk, Marcin; Kudryavtsev, Vasily; Kurek, Krzysztof; Kvaratskheliya, Tengiz; La Thi, Viet Nga; Lacarrere, Daniel; Lafferty, George; Lai, Adriano; Lambert, Dean; Lambert, Robert W; Lanciotti, Elisa; Lanfranchi, Gaia; Langenbruch, Christoph; Latham, Thomas; Lazzeroni, Cristina; Le Gac, Renaud; van Leerdam, Jeroen; Lees, Jean-Pierre; Lefèvre, Regis; Leflat, Alexander; Lefrançois, Jacques; Leo, Sabato; Leroy, Olivier; Lesiak, Tadeusz; Leverington, Blake; Li, Yiming; Liles, Myfanwy; Lindner, Rolf; Linn, Christian; Lionetto, Federica; Liu, Bo; Liu, Guoming; Lohn, Stefan; Longstaff, Ian; Lopes, Jose; Lopez-March, Neus; Lowdon, Peter; Lu, Haiting; Lucchesi, Donatella; Luisier, Johan; Luo, Haofei; Luppi, Eleonora; Lupton, Oliver; Machefert, Frederic; Machikhiliyan, Irina V; Maciuc, Florin; Maev, Oleg; Malde, Sneha; Manca, Giulia; Mancinelli, Giampiero; Manzali, Matteo; Maratas, Jan; Marconi, Umberto; Marino, Pietro; Märki, Raphael; Marks, Jörg; Martellotti, Giuseppe; Martens, Aurelien; Martín Sánchez, Alexandra; Martinelli, Maurizio; Martinez Santos, Diego; Martinez Vidal, Fernando; Martins Tostes, Danielle; Massafferri, André; Matev, Rosen; Mathe, Zoltan; Matteuzzi, Clara; Mazurov, Alexander; McCann, Michael; McCarthy, James; McNab, Andrew; McNulty, Ronan; McSkelly, Ben; Meadows, Brian; Meier, Frank; Meissner, Marco; Merk, Marcel; Milanes, Diego Alejandro; Minard, Marie-Noelle; Molina Rodriguez, Josue; Monteil, Stephane; Moran, Dermot; Morandin, Mauro; Morawski, Piotr; Mordà, Alessandro; Morello, Michael Joseph; Mountain, Raymond; Muheim, Franz; Müller, Katharina; Muresan, Raluca; Muryn, Bogdan; Muster, Bastien; Naik, Paras; Nakada, Tatsuya; Nandakumar, Raja; Nasteva, Irina; Needham, Matthew; Neri, Nicola; Neubert, Sebastian; Neufeld, Niko; Nguyen, Anh Duc; Nguyen, Thi-Dung; Nguyen-Mau, Chung; Nicol, Michelle; Niess, Valentin; Niet, Ramon; Nikitin, Nikolay; Nikodem, Thomas; Novoselov, Alexey; Oblakowska-Mucha, Agnieszka; Obraztsov, Vladimir; Oggero, Serena; Ogilvy, Stephen; Okhrimenko, Oleksandr; Oldeman, Rudolf; Onderwater, Gerco; Orlandea, Marius; Otalora Goicochea, Juan Martin; Owen, Patrick; Oyanguren, Maria Arantza; Pal, Bilas Kanti; Palano, Antimo; Palombo, Fernando; Palutan, Matteo; Panman, Jacob; Papanestis, Antonios; Pappagallo, Marco; Pappalardo, Luciano; Parkes, Christopher; Parkinson, Christopher John; Passaleva, Giovanni; Patel, Girish; Patel, Mitesh; Patrignani, Claudia; Pavel-Nicorescu, Carmen; Pazos Alvarez, Antonio; Pearce, Alex; Pellegrino, Antonio; Penso, Gianni; Pepe Altarelli, Monica; Perazzini, Stefano; Perez Trigo, Eliseo; Perret, Pascal; Perrin-Terrin, Mathieu; Pescatore, Luca; Pesen, Erhan; Pessina, Gianluigi; Petridis, Konstantin; Petrolini, Alessandro; Picatoste Olloqui, Eduardo; Pietrzyk, Boleslaw; Pilař, Tomas; Pinci, Davide; Pistone, Alessandro; Playfer, Stephen; Plo Casasus, Maximo; Polci, Francesco; Polok, Grzegorz; Poluektov, Anton; Polycarpo, Erica; Popov, Alexander; Popov, Dmitry; Popovici, Bogdan; Potterat, Cédric; Powell, Andrew; Prisciandaro, Jessica; Pritchard, Adrian; Prouve, Claire; Pugatch, Valery; Puig Navarro, Albert; Punzi, Giovanni; Qian, Wenbin; Rachwal, Bartolomiej; Rademacker, Jonas; Rakotomiaramanana, Barinjaka; Rama, Matteo; Rangel, Murilo; Raniuk, Iurii; Rauschmayr, Nathalie; Raven, Gerhard; Redford, Sophie; Reichert, Stefanie; Reid, Matthew; dos Reis, Alberto; Ricciardi, Stefania; Richards, Alexander; Rinnert, Kurt; Rives Molina, Vincente; Roa Romero, Diego; Robbe, Patrick; Roberts, Douglas; Rodrigues, Ana Barbara; Rodrigues, Eduardo; Rodriguez Perez, Pablo; Roiser, Stefan; Romanovsky, Vladimir; Romero Vidal, Antonio; Rotondo, Marcello; Rouvinet, Julien; Ruf, Thomas; Ruffini, Fabrizio; Ruiz, Hugo; Ruiz Valls, Pablo; Sabatino, Giovanni; Saborido Silva, Juan Jose; Sagidova, Naylya; Sail, Paul; Saitta, Biagio; Salustino Guimaraes, Valdir; Sanmartin Sedes, Brais; Santacesaria, Roberta; Santamarina Rios, Cibran; Santovetti, Emanuele; Sapunov, Matvey; Sarti, Alessio; Satriano, Celestina; Satta, Alessia; Savrie, Mauro; Savrina, Darya; Schiller, Manuel; Schindler, Heinrich; Schlupp, Maximilian; Schmelling, Michael; Schmidt, Burkhard; Schneider, Olivier; Schopper, Andreas; Schune, Marie Helene; Schwemmer, Rainer; Sciascia, Barbara; Sciubba, Adalberto; Seco, Marcos; Semennikov, Alexander; Senderowska, Katarzyna; Sepp, Indrek; Serra, Nicola; Serrano, Justine; Seyfert, Paul; Shapkin, Mikhail; Shapoval, Illya; Shcheglov, Yury; Shears, Tara; Shekhtman, Lev; Shevchenko, Oksana; Shevchenko, Vladimir; Shires, Alexander; Silva Coutinho, Rafael; Simi, Gabriele; Sirendi, Marek; Skidmore, Nicola; Skwarnicki, Tomasz; Smith, Anthony; Smith, Edmund; Smith, Eluned; Smith, Jackson; Smith, Mark; Snoek, Hella; Sokoloff, Michael; Soler, Paul; Soomro, Fatima; Souza, Daniel; Souza De Paula, Bruno; Spaan, Bernhard; Sparkes, Ailsa; Spinella, Franco; Spradlin, Patrick; Stagni, Federico; Stahl, Sascha; Steinkamp, Olaf; Stevenson, Scott; Stoica, Sabin; Stone, Sheldon; Storaci, Barbara; Stracka, Simone; Straticiuc, Mihai; Straumann, Ulrich; Stroili, Roberto; Subbiah, Vijay Kartik; Sun, Liang; Sutcliffe, William; Swientek, Stefan; Syropoulos, Vasileios; Szczekowski, Marek; Szczypka, Paul; Szilard, Daniela; Szumlak, Tomasz; T'Jampens, Stephane; Teklishyn, Maksym; Tellarini, Giulia; Teodorescu, Eliza; Teubert, Frederic; Thomas, Christopher; Thomas, Eric; van Tilburg, Jeroen; Tisserand, Vincent; Tobin, Mark; Tolk, Siim; Tomassetti, Luca; Tonelli, Diego; Topp-Joergensen, Stig; Torr, Nicholas; Tournefier, Edwige; Tourneur, Stephane; Tran, Minh Tâm; Tresch, Marco; Tsaregorodtsev, Andrei; Tsopelas, Panagiotis; Tuning, Niels; Ubeda Garcia, Mario; Ukleja, Artur; Ustyuzhanin, Andrey; Uwer, Ulrich; Vagnoni, Vincenzo; Valenti, Giovanni; Vallier, Alexis; Vazquez Gomez, Ricardo; Vazquez Regueiro, Pablo; Vázquez Sierra, Carlos; Vecchi, Stefania; Velthuis, Jaap; Veltri, Michele; Veneziano, Giovanni; Vesterinen, Mika; Viaud, Benoit; Vieira, Daniel; Vilasis-Cardona, Xavier; Vollhardt, Achim; Volyanskyy, Dmytro; Voong, David; Vorobyev, Alexey; Vorobyev, Vitaly; Voß, Christian; Voss, Helge; de Vries, Jacco; Waldi, Roland; Wallace, Charlotte; Wallace, Ronan; Wandernoth, Sebastian; Wang, Jianchun; Ward, David; Watson, Nigel; Webber, Adam Dane; Websdale, David; Whitehead, Mark; Wicht, Jean; Wiechczynski, Jaroslaw; Wiedner, Dirk; Wiggers, Leo; Wilkinson, Guy; Williams, Matthew; Williams, Mike; Wilson, Fergus; Wimberley, Jack; Wishahi, Julian; Wislicki, Wojciech; Witek, Mariusz; Wormser, Guy; Wotton, Stephen; Wright, Simon; Wu, Suzhi; Wyllie, Kenneth; Xie, Yuehong; Xing, Zhou; Yang, Zhenwei; Yuan, Xuhao; Yushchenko, Oleg; Zangoli, Maria; Zavertyaev, Mikhail; Zhang, Feng; Zhang, Liming; Zhang, Wen Chao; Zhang, Yanxi; Zhelezov, Alexey; Zhokhov, Anatoly; Zhong, Liang; Zvyagin, Alexander

    2014-01-01

    The production of $\\Upsilon(1S)$, $\\Upsilon(2S)$ and $\\Upsilon(3S)$ mesons decaying into the dimuon final state is studied with the LHCb detector using a data sample corresponding to an integrated luminosity of 3.3 $pb^{-1}$ collected in proton-proton collisions at a centre-of-mass energy of $\\sqrt{s}=2.76$ TeV. The differential production cross-sections times dimuon branching fractions are measured as functions of the $\\Upsilon$ transverse momentum and rapidity, over the ranges $p_{\\rm T}<15$ GeV/$c$ and $2.0pp \\rightarrow \\Upsilon(1S) \\mathrm{X} \\right) \\times B\\left( \\Upsilon(1S) \\rightarrow \\mu^{+}\\mu^{-} \\right) & = & 1.111 \\pm 0.043 \\pm 0.044 nb, \\\\ \\sigma \\left( pp \\rightarrow \\Upsilon(2S) \\mathrm{X} \\right) \\times B\\left(\\Upsilon(2S) \\rightarrow \\mu^{+}\\mu^{-} \\right) & = & 0.264 \\pm 0.023 \\pm 0.011 nb, \\\\ \\sigma \\left( pp \\rig...

  16. Structures in anti pp → π π

    International Nuclear Information System (INIS)

    Martin, B.R.; Morgan, D.

    1980-03-01

    A Barrelet-zero analysis is presented of data on anti pp → π π in the momentum range 1 to 2 GeV/c. With π - π + data alone, the scope for ambiguity is very large but the addition of π 0 π 0 information enables the number of solutions to be reduced to just a few. Although the alternative solutions differ considerably, they have significant common features, in particular, with plausible extra assumptions, all solutions appear to be dominated by resonance in all spin states from J = 1 to 5

  17. NA61/SHINE results on fluctuations and correlations in p+p and Be+Be interactions at CERN SPS energies

    CERN Document Server

    Mackowiak-Pawlowska, Maja

    2016-01-01

    The aim of the NA61/SHINE strong interaction program is to explore the phase diagram of strongly interacting matter. The main physics goals are the study of the onset of deconfinement and the search for the critical point of strongly interacting matter. These goals are pursued by performing a beam momentum (13$A$ - 158$A$ GeV/c) and system size (p+p, p+Pb, Be+Be, Ar+Sc, Xe+La) scan. This contribution presents results on transverse momentum and multiplicity fluctuations from the Be+Be and p+p energy scan. Also, results on two-particle correlations in pseudorapidity and azimuthal angle obtained in p+p interactions will be shown. The influence of conservation laws and resonance decays on multiplicity and chemical fluctuations of identified particles in p+p interactions will be discussed. Obtained results will be compared with data from other experiments and with model predictions.

  18. Multi-strange baryon production in pp, p-Pb and Pb-Pb collisions measured with ALICE

    CERN Document Server

    Colella, Domenico

    2014-01-01

    The production of {\\Xi}$^{-}$ and {\\Omega}$^{-}$ baryons and their anti-particles in pp, p-Pb and Pb-Pb collisions has been measured by the ALICE Collaboration. These hyperons are reconstructed via the detection of their charged weak-decay products, which are identified through their measured ionisation losses and momenta in the ALICE Time Projection Chamber. Comparing the production yields in Pb-Pb and pp collisions, a strangeness enhancement has been measured and found to increase with the centrality of the collision and with the strangeness content of the baryon; moreover, in the comparison with similar measurements at lower energies, it decreases as the centre-of-mass energy increases, following the trend already observed moving from SPS to RHIC. Recent measurement of cascade and {\\Omega} in p-Pb interactions are compared with results in Pb-Pb and pp collisions and with predictions from thermal models, based on a grand canonical approach. The nuclear modification factors for the charged {\\Xi} and {\\Omega}...

  19. NN wave function at small distances and hard bremsstrahlung in the process pp→ppγ

    International Nuclear Information System (INIS)

    Neudatchin, V. G.; Khokhlov, N. A.; Shirokov, A. M.; Knyr, V. A.

    1997-01-01

    Various possibilities of studying the NN wave function at small distances--and in particular, quark degrees of freedom in the NN system--are discussed. It is shown that there is such a possibility at moderate energies--namely, hard bremsstrahlung in the process pp→ppγ at proton-beam energies in the range 350-450 MeV permits distinguishing between the pp wave function with nodes in S and P waves that corresponds to the Moscow potential of NN interaction from functions obtained with repulsive-core mesonic potentials. In the regions where photon energies in the c.m.s. are maximal (forward and backward photon emission angles in the laboratory frame), the pp→ppγ cross section calculated with the Moscow potential has maxima at which it is approximately five times larger than the analogous cross section calculated with repulsive-core mesonic potentials. The coordinate-representation formalism of the theory of bremsstrahlung is expounded

  20. Electronic control devices

    International Nuclear Information System (INIS)

    Hartill, D.L.

    1981-01-01

    The subject of these lectures is the translation of information from particle detectors to computers. Large solid angle general purpose detectors at the intersection regions of high energy e+e- storage rings and pp and pp storage rings are discussed. Three choices for data acquisition are reviewed: use CAMAC (Computer Aided Measurement and Control), start from scratch and design a system, or wait for the final version of the proposed FASTBUS to be developed. The do-it-yourself procedure includes designs of drift chamber discriminator, time to amplitude converter, and data card block diagram. Trigger systems, the fast decision making systems judging an event interesting enough for a read-out cycle to be initiated, are discussed. Finally, a FASTBUS system layout, with its goals of minimum bus speed, general system topologies, and support multiple smart devices is given

  1. Polymers pipeline study (PP and PEAD) for paraffin deposits inhibition: static (contact angle) and with flow (depolarization of the petroleum fluorescence); Estudo de dutos polimericos (PP e PEAD) para inibicao de depositos parafinicos: estatico (angulo de contato) e com fluxo (despolarizacao da fluorescencia do petroleo)

    Energy Technology Data Exchange (ETDEWEB)

    Quintella, Cristina M.; Castro, Martha T.P.O.; Musse, Ana Paula S. [Universidade Federal da Bahia, Salvador, BA (Brazil)

    2003-07-01

    This work evaluated the formation of paraffin deposits as a function of the chemical constitution of the pipeline walls. Two low cost polymers, available in the Brazilian market either as solids or as extruded films, were studied: polypropylene (PP) and high density polyethylene (PEAD). The static interfacial interactions were evaluated by contact angle and showed that the interaction between crude oil and PEAD was 16% stronger than with PP. For the dynamic studies a flow cell was developed in order to observe mainly the boundary layers. The paraffin deposits were identified through the decrease of the intermolecular alignment within the flowing oil. PEAD proved to be 43% more efficient that PP in interacting with the crude oil. Under flowing conditions, the chemical interfacial effects became more pronounced due to the molecular effects overcoming the hydrodynamic effects. Photos of the cell walls showed globular paraffin deposits on PEAD and their absence on PP. As both polymers are linear, the higher tendency of PEAD to yield paraffin deposits was attributed to the absence of lateral branches of methyl groups. There by PP was found to be better than PEAD to avoid paraffin deposition. (author)

  2. Structural characterisation and antibacterial activity of PP/TiO2 nanocomposites prepared by an in situ sol–gel method

    International Nuclear Information System (INIS)

    Bahloul, Walid; Mélis, Flavien; Bounor-Legaré, Véronique; Cassagnau, Philippe

    2012-01-01

    Graphical abstract: TEM micrograph of PP/TiO 2 nanocomposite materials (a) in situ PP/TiO 2 and (b) PP/TiO 2 (anatase). Highlights: ► Titanium alkoxide hydrolysis–condensation reactions during polypropylene processing. ► Inorganic domains diameter of around 10 nm. ► Interesting antibacterial activities compared to a dispersion of anatase TiO 2 . - Abstract: Polypropylene/titanium dioxide (PP/TiO 2 ) nanocomposites can be prepared using a novel method based on the hydrolysis–condensation reactions (sol–gel method) of titanium alkoxide inorganic precursors that have been premixed with polypropylene under molten conditions. The resultant nanocomposites were characterised by transmission electronic microscopy (TEM), X-ray diffraction, Raman spectroscopy and X-ray photoelectron spectroscopy (XPS). These techniques showed the formation of the titanium oxi-hydroxide chemical structure (Ti x O y (OH) z ) with a diameter of approximately 10 nm in the polymer matrix. Furthermore, a condensation degree of around 17% was determined using XPS analysis. The antibacterial activity was tested according to the JIS Z 2801:2000 standard with Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) in the absence of light. Correlations between the microstructure and the chemical composition of PP/TiO 2 nanocomposites and the antibacterial properties of these nanocomposites were discussed. The structure of titanium oxi-hydroxide derivative particles (Ti x O y (OH) z ) within the polypropylene matrix has been shown to impact strongly on the antibacterial properties in comparison with the results obtained with a dispersion of anatase titanium dioxide into the PP.

  3. Search for narrow p states in the reaction pi /sup -/p to p pi /sup - /pp at 16 GeV/c

    CERN Document Server

    Chung, S U; Bensinger, J; Button-Shafer, J; Dhar, S; Dowd, J; Etkin, A; Fernow, R; Foley, K; Goldman, J H; Kern, W; Kirk, H; Kopp, J; Kramer, M A; Lesnik, A; Lichti, R; Lindenbaum, S J; Love, W; Mallik, U; Morris, T; Morris, W; Ozaki, S; Platner, E; Protopopescu, S D; Saulys, A; Weygand, D P; Wheeler, C D; Willen, E; Winik, M

    1981-01-01

    The authors have carried out a sensitive (>or approximately=5 events /nb) search for narrow pp states at the BNL Multiparticle Spectrometer. They found no evidence of narrow pp states at 2020 and 2200 MeV in the reaction pi /sup -/p to p pi /sup -/pp at 16 GeV/c. The authors quote 2 sigma upper limits of or approximately=5 sigma signals at 2020 and 2200 MeV. (5 refs).

  4. 75 FR 78705 - Issuance of Exposure Drafts on Implementation Guidance on the Accounting for the Disposal of G-PP...

    Science.gov (United States)

    2010-12-16

    ... FEDERAL ACCOUNTING STANDARDS ADVISORY BOARD Issuance of Exposure Drafts on Implementation Guidance on the Accounting for the Disposal of G-PP&E and Implementation Guidance for Estimating the Historical Cost of G-PP&E AGENCY: Federal Accounting Standards Advisory Board. ACTION: Notice. Board Action...

  5. Integrated Control Sytems of Mycotoxin Contamination

    OpenAIRE

    Name Romsyah

    2006-01-01

    Contamination of mycotoxins produced by Aspergillus spp., Fusarium spp . and Penicillium s pp . i n agricultural products has been a concern regarding their effect to health and economic impact. Integrated control system should be based on Hazard Analysis and Critical Control Point (HACCP) approach involving Good Agricultural Practices (GAP) and Good Manufacturing Practices (GMP) . Prevention should be carried out through pre harvest, harvest, post harvest, as well as control quality at all s...

  6. Neutral meson production in pp and Pb-Pb collisions at the LHC with ALICE

    International Nuclear Information System (INIS)

    Borissov, Alexander

    2013-01-01

    The first measurements of the invariant differential cross sections of inclusive π 0 and η meson production with ALICE are presented for pp collisions at √(s) = 0.9 and 7 TeV. Next-to-Leading Order perturbative QCD calculations overestimate the data at √(s) = 7TeV, but are consistent with the π 0 spectrum at √(s) = 0.9TeV and with the measured π 0 /η cross section ratio at √(s) = 7TeV. The nuclear modification factors (R AA ) of π 0 production at different centralities show a strong suppression with respect to pp collisions.

  7. Internal Targeting and External Control: Phototriggered Targeting in Nanomedicine.

    Science.gov (United States)

    Arrue, Lily; Ratjen, Lars

    2017-12-