78 FR 73555 - Deepwater Horizon Oil Spill; Draft Programmatic and Phase III Early Restoration Plan and Draft...

Science.gov (United States)

2013-12-06

... Environmental Impact Statement (Draft Phase III ERP/PEIS). The Draft Phase III ERP/PEIS considers programmatic... programmatic restoration alternatives. The Draft Phase III ERP/PEIS evaluates these restoration alternatives... the Framework Agreement. The Draft Phase III ERP/PEIS also evaluates the environmental consequences of...

Power systems for the Doublet III 2-MW ECH system

International Nuclear Information System (INIS)

Remsen, D.B. Jr.

1981-10-01

A system providing 5 second pulses at 60 GHz from ten 200 kW gyrotrons is being prepared for electron cyclotron heating experiments on Doublet III. The power supply for the gyrotron system is a power supply currently under construction by Universal Voltronics Corporation for the Doublet III neutral beam power supply, and is to have the option of reverse polarity (negative) to fill the needs of the system of ten gyrotons operating in parallel. The output of this power supply is 80 kV at 100A for 5 second pulses with good regulation. The output pulse rise and fall times and fault protection response time are all compatible with the gyrotron requirements

Remedial Design/Remedial Action Work Plan for Operable Units 6-05 and 10-04, Phase III

Energy Technology Data Exchange (ETDEWEB)

R. P. Wells

2006-09-19

The remedial design/remedial action for Operable Unit 6-05 (Waste Area Group 6) and Operable Unit 10-04 (Waste Area Group 10) - collectively called Operable Unit 10-04 has been divided into four phases. Phase I consists of developing and implementing institutional controls at Operable Unit 10-04 sites and developing and implementing Idaho National Laboratory-wide plans for both institutional controls and ecological monitoring. Phase II will remediate sites contaminated with trinitrotoluene and Royal Demolition Explosive. Phase III will remediate lead contamination at a gun range, and Phase IV will remediate hazards from unexploded ordnance. This Phase III remedial Design/Remedial Action Work Plan addresses the remediation of lead-contaminated soils found at the Security Training Facility (STF)-02 Gun Range located at the Idaho National Laboratory. Remediation of the STF-02 Gun Range will include excavating contaminated soils; physically separating copper and lead for recycling; returning separated soils below the remediation goal to the site; stabilizing contaminated soils, as required, and disposing of the separated soils that exceed the remediation goal; encapsulating and disposing of creosote-contaminated railroad ties and power poles; removing and disposing of the wooden building and asphalt pads found at the STF-02 Gun Range; sampling and analyzing soil to determine the excavation requirements; and when the remediation goals have been met, backfilling and contouring excavated areas and revegetating the affected area.

Solar neutrino oscillation parameters after SNO Phase-III and SAGE Part-III

International Nuclear Information System (INIS)

Yang Ping; Liu Qiuyu

2009-01-01

We analyse the recently published results from solar neutrino experiments SNO Phase-III and SAGE Part-III and show their constraints on solar neutrino oscillation parameters, especially for the mixing angle θ 12 . Through a global analysis using all existing data from SK, SNO, Ga and Cl radiochemical experiments and long base line reactor experiment KamLAND , we obtain the parameters Δm 12 2 =7.684 -0.208 +0.212 x 10 -5 eV 2 , tan 2 θ 12 =0.440 -0.057 +0.059 . We also find that the discrepancy between the KamLAND and solar neutrino results can be reduced by choosing a small non-zero value for the mixing angle θ 13 . (authors)

Power inverter implementing phase skipping control

Science.gov (United States)

Somani, Utsav; Amirahmadi, Ahmadreza; Jourdan, Charles; Batarseh, Issa

2016-10-18

A power inverter includes a DC/AC inverter having first, second and third phase circuitry coupled to receive power from a power source. A controller is coupled to a driver for each of the first, second and third phase circuitry (control input drivers). The controller includes an associated memory storing a phase skipping control algorithm, wherein the controller is coupled to receive updating information including a power level generated by the power source. The drivers are coupled to control inputs of the first, second and third phase circuitry, where the drivers are configured for receiving phase skipping control signals from the controller and outputting mode selection signals configured to dynamically select an operating mode for the DC/AC inverter from a Normal Control operation and a Phase Skipping Control operation which have different power injection patterns through the first, second and third phase circuitry depending upon the power level.

Phase III Simplified Integrated Test (SIT) results - Space Station ECLSS testing

Science.gov (United States)

Roberts, Barry C.; Carrasquillo, Robyn L.; Dubiel, Melissa Y.; Ogle, Kathryn Y.; Perry, Jay L.; Whitley, Ken M.

1990-01-01

During 1989, phase III testing of Space Station Freedom Environmental Control and Life Support Systems (ECLSS) began at Marshall Space Flight Center (MSFC) with the Simplified Integrated Test. This test, conducted at the MSFC Core Module Integration Facility (CMIF), was the first time the four baseline air revitalization subsystems were integrated together. This paper details the results and lessons learned from the phase III SIT. Future plans for testing at the MSFC CMIF are also discussed.

The application and design of distributed control system in reactor shutdown system of Qinshan phase III

International Nuclear Information System (INIS)

Su Guoquan; Liu Wangtian; Yu Yijun; Xiong Weihua

2006-03-01

The design, commissioning and running of the reactor trip parameter monitoring system used in Qinshan Phase III are introduced. The applying technology of Distributed Control System realized trip parameter monitoring and realized the function of trip parameters quick data acquisitioning, transferring, saving, alarm, query. The applying of trip parameters monitoring system improved the abilities of plant status monitoring and event analyzing, and increased the security and economy of nuclear power plant. (authors)

Aqueous phase complexation of Cm(III) and Cf(III) with ionizable macrocyclic ligands

International Nuclear Information System (INIS)

Manchanda, V.K.; Mohapatra, P.K.

1995-01-01

Complexation behaviour of Cm(III) and Cf(III) with 1,7-diaza-4,10,13-trioxacyclopentadecane-N,N'-diacetic acid (K21DA), 1,10-diaza-4,7,13,16-tetraoxacyclooctadecane-N,N'-diacetic acid (K22DA) and ethylene diamine N,N'- diacetic acid (EDDA) has been investigated using dinonyl naphthalene sulphonic acid (DNNS), in tetramethyl ammonium form as liquid cation exchanger. The aqueous phase complex formation constants are computed from the distribution data. Though larger complex formation constants are observed with K21DA as well as K22DA compared to those with the acyclic analog EDDA, no size correlation is observed. (author). 5 refs., 1 tab

The Qinshan phase III project-a successful model of sino-canadian cooperation

International Nuclear Information System (INIS)

Pang, S.H.H.; Alikhan, S.; Gu Jun

2005-01-01

The Qinshan Phase III (CANDU) Project, the largest-scale cooperative project between China and Canada, was completed in 2003 well in advance of the schedule and 10% under budget. The Third Qinshan (Phase III) Nuclear Power Plant (TQNPP) was built in record times: Unit 1 achieved commercial operation on December 31, 2002 and Unit 2 on July 20, 2003, 43 days and 115 days ahead of schedule respectively. Improvements in design and construction methods allowed Unit 1 to be constructed in 51.5 months from First Concrete to Criticality - a record in China for nuclear power plants. The key factors are project management and project management tools, quality assurance, construction methods, electronic documentation with configuration control that provides up-to-date on-line information, CADDS design linked with material management and control. New design and construction techniques were introduced by combining conventional AECL practices with working experiences in China. The most advanced tools and techniques for achieving optimum construction quality, schedule and cost were used. Successful application of advanced project management methods and tools has benefited TQNPC in its subsequent plant operation, and the Chinese contractors in advancing their capabilities in future nuclear projects in China as well as enhancing their opportunities internationally. Excellent co-operation and teamwork within the integrated TQNPC/AECL Commissioning Team with well documented QA program, process and procedures also contributed to the remarkable success of the Project. AECL's initial assessment, based on lessons learned, showed that the project schedule could readily be reduced to 66 months and the capital costs reduced by 25% for a replication project. AECL is building on this experience and successful results of TQNPP in its Advanced CANDU Reactor TM (ACR TM ) ** design. (authors)

Superconductivity in the unconventional high pressure phase bismuth-III

Energy Technology Data Exchange (ETDEWEB)

Semeniuk, Konstantin; Brown, Philip; Vasiljkovic, Aleksandar; Grosche, Malte [University of Cambridge (United Kingdom)

2015-07-01

One of the most surprising developments in high pressure research was the realisation that many elements assume very unexpected high pressure structures, described in terms of extremely large or even infinite unit cells. Elemental bismuth, which has been known to undergo a series of pressure induced structural transitions between 25 kbar and 80 kbar, is an interesting example: the intermediate pressure Bi-III phase has a complex 'host-guest' structure consisting of two incommensurate sublattices. Since the unit cell is infinitely large, the description of electronic and lattice excitations is problematic. Apart from its metallic character and the observation of superconductivity at low temperature, little is known about the electronic structure in this phase. We investigate the electrical resistivity within the metallic Bi-III phase under high hydrostatic pressure and in applied magnetic field using a piston cylinder cell. Superconductivity is observed below 7.1 K, and we extract the temperature dependence of the upper critical field, which exceeds 2 T at low temperature. The normal state resistivity exhibits an approximately linear temperature dependence. This could be attributed to strong scattering from low-lying excitations, as caused by an unusually soft phonon spectrum. The results suggest that strong coupling superconductivity arises within the host-guest structure of Bi-III out of an unusual electronic state.

Palestinian Adolescents Coping with Trauma (PACT) - Phase III ...

International Development Research Centre (IDRC) Digital Library (Canada)

Palestinian Adolescents Coping with Trauma (PACT) - Phase III. Violent conflict has been repeatedly shown to result in severe, long-term social and mental health problems for exposed children and adolescents. While in the developed world, it is generally accepted that individuals seek professional one-on-one ...

Load Flow and Short Circuit Analysis of the Class III Power System of HANARO

Energy Technology Data Exchange (ETDEWEB)

Kim, H. K.; Jung, H. S

2005-12-15

The planning, design, and operation of electric power system require engineering studies to assist in the evaluation of the system performance, reliability, safety and economics. The Class III power of HANARO supplies power for not only HANARO but also RIPF and IMEF. The starting current of most ac motors is five to ten times normal full load current. The loads of the Class III power are connected in consecutive orders at an interval for 10 seconds to avoid excessive voltage drop. This technical report deals with the load flow study and motor starting study for the Class III power of HANARO using ETAP(Electrical Transient Analyzer Program) to verify the capacity of the diesel generator. Short-circuit studies are done to determine the magnitude of the prospective currents flowing throughout the power system at various time intervals after a fault occurs. Short-circuit studies can be performed at the planning stage in order to help finalize the system layout, determine voltage levels, and size cables, transformers, and conductors. From this study, we verify the short circuit current capacity of air circuit breaker(ACB) and automatic transfer switch(ATS) of the Class III power.

Validation of the U.S. NRC coupled code system TRITON/TRACE/PARCS with the special power excursion reactor test III (SPERT III)

Energy Technology Data Exchange (ETDEWEB)

Wang, R. C.; Xu, Y.; Downar, T. [Dept. of Nuclear Engineering and Radiological Sciences, Univ. of Michigan, Ann Arbor, MI 48104 (United States); Hudson, N. [RES Div., U.S. NRC, Rockville, MD (United States)

2012-07-01

The Special Power Excursion Reactor Test III (SPERT III) was a series of reactivity insertion experiments conducted in the 1950's. This paper describes the validation of the U.S. NRC Coupled Code system TRITON/PARCS/TRACE to simulate reactivity insertion accidents (RIA) by using several of the SPERT III tests. The work here used the SPERT III E-core configuration tests in which the RIA was initiated by ejecting a control rod. The resulting super-prompt reactivity excursion and negative reactivity feedback produced the familiar bell shaped power increase and decrease. The energy deposition during such a power peak has important safety consequences and provides validation basis for core coupled multi-physics codes. The transients of five separate tests are used to benchmark the PARCS/TRACE coupled code. The models were thoroughly validated using the original experiment documentation. (authors)

CHAOS. III. GAS-PHASE ABUNDANCES IN NGC 5457

Energy Technology Data Exchange (ETDEWEB)

Croxall, Kevin V.; Pogge, Richard W. [Department of Astronomy, The Ohio State University, 140 West 18th Avenue, Columbus, OH 43210 (United States); Berg, Danielle A. [Center for Gravitation, Cosmology and Astrophysics, Department of Physics, University of Wisconsin Milwaukee, 1900 East Kenwood Boulevard, Milwaukee, WI 53211 (United States); Skillman, Evan D. [Minnesota Institute for Astrophysics, University of Minnesota, 116 Church Street SE, Minneapolis, MN 55455 (United States); Moustakas, John [Department of Physics and Astronomy, Siena College, 515 Loudon Road, Loudonville, NY 12211 (United States)

2016-10-10

We present Large Binocular Telescope observations of 109 H ii regions in NGC 5457 (M101) obtained with the Multi-Object Double Spectrograph. We have robust measurements of one or more temperature-sensitive auroral emission lines for 74 H ii regions, permitting the measurement of “direct” gas-phase abundances. Comparing the temperatures derived from the different ionic species, we find: (1) strong correlations of T [N ii] with T [S iii] and T [O iii], consistent with little or no intrinsic scatter; (2) a correlation of T [S iii] with T [O iii], but with significant intrinsic dispersion; (3) overall agreement between T [N ii], T [S ii], and T [O ii], as expected, but with significant outliers; (4) the correlations of T [N ii] with T [S iii] and T [O iii] match the predictions of photoionization modeling while the correlation of T [S iii] with T [O iii] is offset from the prediction of photoionization modeling. Based on these observations, which include significantly more observations of lower excitation H ii regions, missing in many analyses, we inspect the commonly used ionization correction factors (ICFs) for unobserved ionic species and propose new empirical ICFs for S and Ar. We have discovered an unexpected population of H ii regions with a significant offset to low values in Ne/O, which defies explanation. We derive radial gradients in O/H and N/O which agree with previous studies. Our large observational database allows us to examine the dispersion in abundances, and we find intrinsic dispersions of 0.074 ± 0.009 in O/H and 0.095 ± 0.009 in N/O (at a given radius). We stress that this measurement of the intrinsic dispersion comes exclusively from direct abundance measurements of H ii regions in NGC 5457.

Individualized Inservice Teacher Education (Project In-Step). Evaluation Report. Phase III.

Science.gov (United States)

Thurber, John C.

This is a report on the third phase of Project IN-STEP, which was intended to develop a viable model for individualized, multi-media in-service teacher education programs. (Phase I and II are reported in ED 033 905, and ED 042 709). The rationale for Phase III was to see if the model could be successfully transferred to an area other than teaching…

Unraveling the Mystery of the Blue Fog: Structure, Properties, and Applications of Amorphous Blue Phase III.

Science.gov (United States)

Gandhi, Sahil Sandesh; Chien, Liang-Chy

2017-12-01

The amorphous blue phase III of cholesteric liquid crystals, also known as the "blue fog," are among the rising stars in materials science that can potentially be used to develop next-generation displays with the ability to compete toe-to-toe with disruptive technologies like organic light-emitting diodes. The structure and properties of the practically unobservable blue phase III have eluded scientists for more than a century since it was discovered. This progress report reviews the developments in this field from both fundamental and applied research perspectives. The first part of this progress report gives an overview of the 130-years-long scientific tour-de-force that very recently resulted in the revelation of the mysterious structure of blue phase III. The second part reviews progress made in the past decade in developing electrooptical, optical, and photonic devices based on blue phase III. The strong and weak aspects of the development of these devices are underlined and criticized, respectively. The third- and-final part proposes ideas for further improvement in blue phase III technology to make it feasible for commercialization and widespread use. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Research ICT Africa (RIA!) - phase III | CRDI - Centre de recherches ...

International Development Research Centre (IDRC) Digital Library (Canada)

Research ICT Africa (RIA!) - phase III. Depuis la création du réseau RIA! en 2003, ses responsables ont mené avec succès des études portant tant sur l'offre que sur la demande afin de permettre de mieux comprendre l'accès aux TIC et leur utilisation en Afrique. Au cours des deux premières phases du projet (nos 101584 ...

Public Policy and Protection from Exclusion - Phase III | IDRC ...

International Development Research Centre (IDRC) Digital Library (Canada)

Public Policy and Protection from Exclusion - Phase III ... and decision-makers active in the promotion of equitable health policies, with a view to promoting the emergence of an observatory of health systems in the ... Policy in Focus publishes a special issue profiling evidence to empower women in the labour market.

Brush Day & Night Phase III to Phase IV: ensuring that good oral health habits are sustainable.

Science.gov (United States)

Melo, Paulo; Fine, Charlotte; Malone, Sinead; Horn, Virginie

2018-05-01

Over the past 10 years, the FDI-Unilever Brush Day & Night partnership has significantly influenced the life of children worldwide through the implementation of school programmes for oral health education and prevention. This article reports the key facts and outcomes of Phase III of the partnership, and announces the launch of Phase IV. During Phase III, the expert advisors of the Brush Day & Night partnership conducted a longitudinal study to evaluate the impact of the '21 Day' programme in almost 8,000 children in 10 countries. Analysis revealed the effectiveness of the 21 Day programme in sustainably educating children to brush their teeth twice a day, with the greatest impact observed in children aged 7-9 years. With the launch of Phase IV, the Brush Day & Night partnership will continue to deliver its oral health school programme for 7-9 year-old children with a strengthened methodology, including randomized sampling and control groups. The scope of the evaluation will be broadened to include oral health-related quality of life indicators, and monitoring of the oral health knowledge of children's parents/carers. © 2018 FDI World Dental Federation.

The coupling of thermochemistry and phase diagrams for group III-V semiconductor systems. Final report

Energy Technology Data Exchange (ETDEWEB)

Anderson, T.J.

1998-07-21

The project was directed at linking the thermochemical properties of III-V compound semiconductors systems with the reported phase diagrams. The solid-liquid phase equilibrium problem was formulated and three approaches to calculating the reduced standard state chemical potential were identified and values were calculated. In addition, thermochemical values for critical properties were measured using solid state electrochemical techniques. These values, along with the standard state chemical potentials and other available thermochemical and phase diagram data, were combined with a critical assessment of selected III-V systems. This work was culminated with a comprehensive assessment of all the III-V binary systems. A novel aspect of the experimental part of this project was the demonstration of the use of a liquid encapsulate to measure component activities by a solid state emf technique in liquid III-V systems that exhibit high vapor pressures at the measurement temperature.

Hybrid Three-Phase/Single-Phase Microgrid Architecture with Power Management Capabilities

DEFF Research Database (Denmark)

Sun, Qiuye; Zhou, Jianguo; Guerrero, Josep M.

2015-01-01

With the fast proliferation of single-phase distributed generation (DG) units and loads integrated into residential microgrids, independent power sharing per phase and full use of the energy generated by DGs have become crucial. To address these issues, this paper proposes a hybrid microgrid...... architecture and its power management strategy. In this microgrid structure, a power sharing unit (PSU), composed of three single-phase back-to-back (SPBTB) converters, is proposed to be installed at the point of common coupling (PCC). The aim of the PSU is mainly to realize the power exchange and coordinated...... control of load power sharing among phases, as well as to allow fully utilization of the energy generated by DGs. Meanwhile, the method combining the modified adaptive backstepping-sliding mode control approach and droop control is also proposed to design the SPBTB system controllers. With the application...

Exploring the Photoreduction of Au(III) Complexes in the Gas-Phase

Science.gov (United States)

Marcum, Jesse C.; Kaufman, Sydney H.; Weber, J. Mathias

2010-06-01

We have used photodissociation spectroscopy to probe the electronic structure and photoreduction of Au(III) in gas-phase complexes containing Cl- and OH-. The gas-phase electronic spectrum of [AuCl_4]- closely resembles the aqueous solution spectrum, showing a lack of strong solvatochromic shifts. Substitution of Cl- ligands with OH- results in a strong blue shift, in agreement with ligand-field theory. Upon excitation, [AuCl_4]- can dissociate by loss of either one or two neutral Cl atoms, resulting in the reduction of gold from Au(III) to Au(II) and Au(I) respectively. The hydroxide substituted complex, [AuCl_2(OH)_2]-, demonstrates similar behavior but the only observable fragment channel is the loss of two neutral OH ligands, leading only to Au(I).

MAQARIN natural analogue study: phase III

International Nuclear Information System (INIS)

Alexander, W.R.; Mazurek, M.; Waber, H.N.; Arlinger, J.; Erlandson, A.C.; Hallbeck, L.; Pedersen, K.; Chambers, A.V.; Haworth, A.; Ilett, D.; Linklater, C.M.; Tweed, C.J.; Chenery, S.R.N.; Kemp, S.J.; Milodowski, A.E.; Pearce, J.M.; Reeder, S.; Rochelle, C.A.; Smith, B.; Wetton, P.D.; Wragg, J.; Clark, I.D.; Karlsson, F.; Khoury, H.N.; Salameh, E.; Lagerblad, B.; Longworth, G.; Savage, D.; Smellie, J.A.T.

1998-12-01

This report represents the conclusion to Phase III of the Maqarin Natural Analogue Study. The main thrust was to establish the origin and chemistry of the Western Springs hyper alkaline groundwaters (Na/K enriched Ca(OH) 2 type) and to study their interaction with rocks of different compositions, as natural analogues to key processes that might occur at an early stage within the 'alkali disturbed zone' of cementitious repositories in different host rocks. Whilst earlier studies at Maqarin were very much site-specific and process-oriented, Phase III provided a regional perspective to the geological evolution of the Maqarin region. This was made possible by greater field access which allowed a more systematic structural and geomorphological study of the area. This has resulted in a greater understanding of the age and spatial relationships concerning formation of the cement zones through spontaneous combustion of the Bituminous Marls, and the subsequent formation of high pH groundwaters at the Eastern and Western Springs locations. At the Western Springs locality, hydrochemical and hydrogeological evaluation of new and published data (plus access to unpublished data), together with detailed mineralogical and geochemical studies, helped to clarify the very earliest stage of cement leachate/host rock interaction. The data were used also to test coupled flow/transport codes developed to assess the long-term evolution of a cementitious repository. Additional objectives addressed include: a) rock matrix diffusion, b) the occurrence and chemical controls on zeolite composition, e) the occurrence and chemical controls on clay stability, and d) the role of microbes, organics and colloids in trace element transport. The Maqarin site now provides a consistent picture explaining the origin of the hyperalkaline groundwaters, and is therefore a unique location for the examination of the mechanisms and processes associated with cementitious repositories. Application of these

On the determination of Zr(IV), Ce((III), Th(IV) and U(VI) in organic phase using arsenazo-I and arsenazo-III

International Nuclear Information System (INIS)

El-Sweify, F.H.; Kamel, M.M.; Shabana, R.

1997-01-01

Some organic extractants of different types, namely tridodecylamine (TDA), tricapryl methyl ammonium chloride (TCMA), di(2-ethylhexyl) phosphoric acid (HDEHP) and 1-[thenoyl-(2)]-3,3,3-trifluoroacetone (HTTA) in xylene have been used to study the extraction behaviour of coloured complexes of Zr(IV), Ce(III), Th(IV) and U(VI) from slightly acidic aqueous solutions of arsenazo-III. Spectrophotometric study for the determination of the aforementioned elements, as well as the colouring agents arsenazo-I and arsenazo-III in the organic phase has been carried out. Some factors affecting the spectrophotometric determination of these elements were studied. These factors were hydrogen ion concentration, concentration of the colouring agents in the aqueous phase and diluent type. Absorption spectra and standard curves are given. The molar extinction coefficients have been calculated. 10 figs

SIMMER-III code-verification. Phase 1

International Nuclear Information System (INIS)

Maschek, W.

1996-05-01

SIMMER-III is a computer code to investigate core disruptive accidents in liquid metal fast reactors but should also be used to investigate safety related problems in other types of advanced reactors. The code is developed by PNC with cooperation of the European partners FZK, CEA and AEA-T. SIMMER-III is a two-dimensional, three-velocity-field, multiphase, multicomponent, Eulerian, fluid-dynamics code coupled with a space-, time-, and energy-dependent neutron dynamics model. In order to model complex flow situations in a postulated disrupting core, mass and energy conservation equations are solved for 27 density components and 16 energy components, respectively. Three velocity fields (two liquid and one vapor) are modeled to simulate the relative motion of different fluid components. An additional static field takes into account the structures available in a reactor (pins, hexans, vessel structures, internal structures etc.). The neutronics is based on the discrete ordinate method (S N method) coupled into a quasistatic dynamic model. The code assessment and verification of the fluid dynamic/thermohydraulic parts of the code is performed in several steps in a joint effort of all partners. The results of the FZK contributions to the first assessment and verification phase is reported. (orig.) [de

Reversed phase partition chromatographic separation of Gd(III) on poly(Crown Ether) column

International Nuclear Information System (INIS)

Mahanwar, K.R.; Sabale, S.R.

2014-01-01

A simple method has been developed for the separation of Gd(III) in hippuric acid medium by using poly(dibenzo-18-crown-6) as stationary phase. The effect of hippuric acid concentration, different eluting agent, foreign ions etc was studied and the optimum conditions were established. Breakthrough capacity of poly(dibenzo-18-crown-6) for Gd(III) was found to be 0.572 ±0.01 mmolg -1 of crown polymer. The separation of Gd(III) from other elements in multicomponent mixtures has been achieved. The method was extended for determination of Gd(III) in real sample. The method is simple, rapid and selective with good reproducibility (approximately ± 2%). Crown ethers are widely used as complexing agent that can selectively capture metal cation in their cavity. This special feature shown by poly (dibenzo-18-crown-6) has been used in our laboratory for selective cation exchanger by column chromatography. No attempts were made for the separation of Gd(III) using hippuric acid media and column chromatography. The present communication describes a simple and sensitive method for the determination of Gd(III) using poly(dibenzo-18-crown-6) as stationary phase in hippuric acid medium. The proposed method affords an attractive feature as compared to the solvent extraction technique i.e. it is free from any organic diluents as an environmental concern

Validation of the Serpent 2-DYNSUB code sequence using the Special Power Excursion Reactor Test III (SPERT III)

International Nuclear Information System (INIS)

Knebel, Miriam; Mercatali, Luigi; Sanchez, Victor; Stieglitz, Robert; Macian-Juan, Rafael

2016-01-01

Highlights: • Full few-group cross section tables created by Monte Carlo lattice code Serpent 2. • Serpent 2 group constant methodology verified for HFP static and transient cases. • Serpent 2-DYNSUB tool chainvalidated using SPERT III REA experiments. • Serpent 2-DYNSUB tool chain suitable to model RIAs in PWRs. - Abstract: The Special Power Excursion Reactor Test III (SPERT III) is studied using the Serpent 2-DYNSUB code sequence in order to validate it for modeling reactivity insertion accidents (RIA) in PWRs. The SPERT III E-core was a thermal research reactor constructed to analyze reactor dynamics. Its configuration resembles a commercial PWR on terms of fuel type, choice of moderator, coolant flow and system pressure. The initial conditions of the rod ejection accident experiments (REA) performed cover cold startup, hot startup, hot standby and operating power scenarios. Eight of these experiments were analyzed in detail. Firstly, multi-dimensional nodal diffusion cross section tables were created for the three-dimensional reactor simulator DYNSUB employing the Monte Carlo neutron transport code Serpent 2. In a second step, DYNSUB stationary simulations were compared to Monte Carlo reference three-dimensional full scale solutions obtained with Serpent 2 (cold startup conditions) and Serpent 2/SUBCHANFLOW (operating power conditions) with a good agreement being observed. The latter tool is an internal coupling of Serpent 2 and the sub-channel thermal-hydraulics code SUBCHANFLOW. Finally, DYNSUB was utilized to study the eight selected transient experiments. Results were found to match measurements well. As the selected experiments cover much of the possible transient (delayed super-critical, prompt super-critical and super-prompt critical excursion) and initial conditions (cold and hot as well as zero, little and full power reactor states) one expects in commercial PWRs, the obtained results give confidence that the Serpent 2-DYNSUB tool chain is

Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma

NARCIS (Netherlands)

Ribas, Antoni; Kefford, Richard; Marshall, Margaret A.; Punt, Cornelis J. A.; Haanen, John B.; Marmol, Maribel; Garbe, Claus; Gogas, Helen; Schachter, Jacob; Linette, Gerald; Lorigan, Paul; Kendra, Kari L.; Maio, Michele; Trefzer, Uwe; Smylie, Michael; McArthur, Grant A.; Dreno, Brigitte; Nathan, Paul D.; Mackiewicz, Jacek; Kirkwood, John M.; Gomez-Navarro, Jesus; Huang, Bo; Pavlov, Dmitri; Hauschild, Axel

2013-01-01

In phase I/II trials, the cytotoxic T lymphocyte-associated antigen-4-blocking monoclonal antibody tremelimumab induced durable responses in a subset of patients with advanced melanoma. This phase III study evaluated overall survival (OS) and other safety and efficacy end points in patients with

Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma.

NARCIS (Netherlands)

Ribas, A.; Kefford, R.; Marshall, Martin; Punt, C.J.A.; Haanen, J.B.; Marmol, M.; Garbe, C.; Gogas, H.; Schachter, J.; Linette, G.; Lorigan, P.; Kendra, K.L.; Maio, M.; Trefzer, U.; Smylie, M.; McArthur, G.A.; Dreno, B.; Nathan, P.D.; Mackiewicz, J.; Kirkwood, J.M.; Gomez-Navarro, J.; Huang, B.; Pavlov, D.; Hauschild, A.

2013-01-01

PURPOSE: In phase I/II trials, the cytotoxic T lymphocyte-associated antigen-4-blocking monoclonal antibody tremelimumab induced durable responses in a subset of patients with advanced melanoma. This phase III study evaluated overall survival (OS) and other safety and efficacy end points in patients

Single phase inverter for a three phase power generation and distribution system

Science.gov (United States)

Lindena, S. J.

1976-01-01

A breadboard design of a single-phase inverter with sinusoidal output voltage for a three-phase power generation and distribution system was developed. The three-phase system consists of three single-phase inverters, whose output voltages are connected in a delta configuration. Upon failure of one inverter the two remaining inverters will continue to deliver three-phase power. Parallel redundancy as offered by two three-phase inverters is substituted by one three-phase inverter assembly with high savings in volume, weight, components count and complexity, and a considerable increase in reliability. The following requirements must be met: (1) Each single-phase, current-fed inverter must be capable of being synchronized to a three-phase reference system such that its output voltage remains phaselocked to its respective reference voltage. (2) Each single-phase, current-fed inverter must be capable of accepting leading and lagging power factors over a range from -0.7 through 1 to +0.7.

Waste retrieval sluicing system vapor sampling and analysis plan for evaluation of organic emissions, process test phase III

International Nuclear Information System (INIS)

SASAKI, L.M.

1999-01-01

This sampling and analysis plan identifies characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements for vapor samples obtained to address vapor issues related to the sluicing of tank 241-C-106. Sampling will be performed in accordance with Waste Retrieval Sluicing System Emissions Collection Phase III (Jones 1999) and Process Test Plan Phase III, Waste Retrieval Sluicing System Emissions Collection (Powers 1999). Analytical requirements include those specified in Request for Ecology Concurrence on Draft Strategy/Path Forward to Address Concerns Regarding Organic Emissions from C-106 Sluicing Activities (Peterson 1998). The Waste Retrieval Sluicing System was installed to retrieve and transfer high-heat sludge from tank 241-C-106 to tank 241-AY-102, which is designed for high-heat waste storage. During initial sluicing of tank 241-C-106 in November 1998, operations were halted due to detection of unexpected high volatile organic compounds in emissions that exceeded regulatory permit limits. Several workers also reported smelling sharp odors and throat irritation. Vapor grab samples from the 296-C-006 ventilation system were taken as soon as possible after detection; the analyses indicated that volatile and semi-volatile organic compounds were present. In December 1998, a process test (phase I) was conducted in which the pumps in tanks 241-C-106 and 241-AY-102 were operated and vapor samples obtained to determine constituents that may be present during active sluicing of tank 241-C-106. The process test was suspended when a jumper leak was detected. On March 7, 1999, phase I1 of the process test was performed; the sluicing system was operated for approximately 7 hours and was ended using the controlled shutdown method when the allowable amount of solids were transferred to 241-AY-102. The phase II test was successful, however, further testing is required to obtain vapor samples at higher emission levels

78 FR 62350 - Lock+ Hydro Friends Fund III, LLC; Western Minnesota Municipal Power Agency; Notice Announcing...

Science.gov (United States)

2013-10-18

.... 14540-000] Lock+ Hydro Friends Fund III, LLC; Western Minnesota Municipal Power Agency; Notice...+ Hydro Friends Fund III, LLC for Project No. 14539-000 and Western Minnesota Municipal Power Agency for... CFR 385.2001(a)(2) (2013). On October 21, 2013, at 10:00 a.m. (Eastern Time), the Secretary of the...

78 FR 70549 - Lock+ Hydro Friends Fund III, LLC, Western Minnesota Municipal Power Agency; Notice Announcing...

Science.gov (United States)

2013-11-26

.... 14540-000] Lock+ Hydro Friends Fund III, LLC, Western Minnesota Municipal Power Agency; Notice...+ Hydro Friends Fund III, LLC for Project No. 14539-000 and Western Minnesota Municipal Power Agency for... CFR.385.2001(a)(2) (2013). On November 25, 2013, at 10:00 a.m. (Eastern Time), the Secretary of the...

Contributions to reversed-phase column selectivity: III. Column hydrogen-bond basicity.

Science.gov (United States)

Carr, P W; Dolan, J W; Dorsey, J G; Snyder, L R; Kirkland, J J

2015-05-22

Column selectivity in reversed-phase chromatography (RPC) can be described in terms of the hydrophobic-subtraction model, which recognizes five solute-column interactions that together determine solute retention and column selectivity: hydrophobic, steric, hydrogen bonding of an acceptor solute (i.e., a hydrogen-bond base) by a stationary-phase donor group (i.e., a silanol), hydrogen bonding of a donor solute (e.g., a carboxylic acid) by a stationary-phase acceptor group, and ionic. Of these five interactions, hydrogen bonding between donor solutes (acids) and stationary-phase acceptor groups is the least well understood; the present study aims at resolving this uncertainty, so far as possible. Previous work suggests that there are three distinct stationary-phase sites for hydrogen-bond interaction with carboxylic acids, which we will refer to as column basicity I, II, and III. All RPC columns exhibit a selective retention of carboxylic acids (column basicity I) in varying degree. This now appears to involve an interaction of the solute with a pair of vicinal silanols in the stationary phase. For some type-A columns, an additional basic site (column basicity II) is similar to that for column basicity I in primarily affecting the retention of carboxylic acids. The latter site appears to be associated with metal contamination of the silica. Finally, for embedded-polar-group (EPG) columns, the polar group can serve as a proton acceptor (column basicity III) for acids, phenols, and other donor solutes. Copyright © 2015 Elsevier B.V. All rights reserved.

MAQARIN natural analogue study: phase III

Energy Technology Data Exchange (ETDEWEB)

Alexander, W R; Mazurek, M; Waber, H N [Univ. of Berne (Switzerland). Institutes of Geology, Mineralogy and Petrology, Rock-Water Interaction Group (GGWW); Arlinger, J; Erlandson, A C; Hallbeck, L; Pedersen, K [Goeteborg University (Sweden). Dept. of General and Marine Microbiology; Boehlmann, W; Fritz, P; Geyer, S; Geyer, W; Hanschman, G; Kopinke, F D; Poerschmann, J [Umweltforschungszentrum Leipzig-Halle (Germany); Chambers, A V; Haworth, A; Ilett, D; Linklater, C M; Tweed, C J [AEA Technology plc, Harwell (United Kingdom); Chenery, S R.N.; Kemp, S J; Milodowski, A E; Pearce, J M; Reeder, S; Rochelle, C A; Smith, B; Wetton, P D; Wragg, J [British Geological Survey, Keyworth (United Kingdom); Clark, I D [Univ. of Ottawa (Canada). Dept. of Geology; Hodginson, E; Hughes, C R [Univ. of Manchester (United Kingdom). Dept. of Earth Sciences; Hyslop, E K [British Geological Survey, Edinburgh (United Kingdom); Karlsson, F [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden); Khoury, H N; Salameh, E [Univ. of Jordan, Amman (Jordan); Lagerblad, B [Cement Institute, Stockholm (Sweden); Longworth, G [Univ. of Manchester (United Kingdom). Dept. of Geology; Pitty, A F [Private consultant, Norwich (United Kingdom); Savage, D [QuantiSci Ltd, Melton Mowbray (United Kingdom); Smellie, J A.T. [ed.; Conterra AB, Uppsala (Sweden)

1998-12-01

This report represents the conclusion to Phase III of the Maqarin Natural Analogue Study. The main thrust was to establish the origin and chemistry of the Western Springs hyper alkaline groundwaters (Na/K enriched Ca(OH){sub 2} type) and to study their interaction with rocks of different compositions, as natural analogues to key processes that might occur at an early stage within the `alkali disturbed zone` of cementitious repositories in different host rocks. Whilst earlier studies at Maqarin were very much site-specific and process-oriented, Phase III provided a regional perspective to the geological evolution of the Maqarin region. This was made possible by greater field access which allowed a more systematic structural and geomorphological study of the area. This has resulted in a greater understanding of the age and spatial relationships concerning formation of the cement zones through spontaneous combustion of the Bituminous Marls, and the subsequent formation of high pH groundwaters at the Eastern and Western Springs locations. At the Western Springs locality, hydrochemical and hydrogeological evaluation of new and published data (plus access to unpublished data), together with detailed mineralogical and geochemical studies, helped to clarify the very earliest stage of cement leachate/host rock interaction. The data were used also to test coupled flow/transport codes developed to assess the long-term evolution of a cementitious repository. Additional objectives addressed include: a) rock matrix diffusion, b) the occurrence and chemical controls on zeolite composition, e) the occurrence and chemical controls on clay stability, and d) the role of microbes, organics and colloids in trace element transport. The Maqarin site now provides a consistent picture explaining the origin of the hyperalkaline groundwaters, and is therefore a unique location for the examination of the mechanisms and processes associated with cementitious repositories. Application of these

CONVERSION EXTRACTION DESULFURIZATION (CED) PHASE III

Energy Technology Data Exchange (ETDEWEB)

James Boltz

2005-03-01

This project was undertaken to refine the Conversion Extraction Desulfurization (CED) technology to efficiently and economically remove sulfur from diesel fuel to levels below 15-ppm. CED is considered a generic term covering all desulfurization processes that involve oxidation and extraction. The CED process first extracts a fraction of the sulfur from the diesel, then selectively oxidizes the remaining sulfur compounds, and finally extracts these oxidized materials. The Department of Energy (DOE) awarded Petro Star Inc. a contract to fund Phase III of the CED process development. Phase III consisted of testing a continuous-flow process, optimization of the process steps, design of a pilot plant, and completion of a market study for licensing the process. Petro Star and the Degussa Corporation in coordination with Koch Modular Process Systems (KMPS) tested six key process steps in a 7.6-centimeter (cm) (3.0-inch) inside diameter (ID) column at gas oil feed rates of 7.8 to 93.3 liters per hour (l/h) (2.1 to 24.6 gallons per hour). The team verified the technical feasibility with respect to hydraulics for each unit operation tested and successfully demonstrated pre-extraction and solvent recovery distillation. Test operations conducted at KMPS demonstrated that the oxidation reaction converted a maximum of 97% of the thiophenes. The CED Process Development Team demonstrated that CED technology is capable of reducing the sulfur content of light atmospheric gas oil from 5,000-ppm to less than 15-ppm within the laboratory scale. In continuous flow trials, the CED process consistently produced fuel with approximately 20-ppm of sulfur. The process economics study calculated an estimated process cost of $5.70 per product barrel. The Kline Company performed a marketing study to evaluate the possibility of licensing the CED technology. Kline concluded that only 13 refineries harbored opportunity for the CED process. The Kline study and the research team's discussions

MAQARIN natural analogue study: phase III

Energy Technology Data Exchange (ETDEWEB)

Alexander, W R; Mazurek, M; Waber, H N [Univ. of Berne (Switzerland). Institutes of Geology, Mineralogy and Petrology, Rock-Water Interaction Group (GGWW); Arlinger, J; Erlandson, A C; Hallbeck, L; Pedersen, K [Goeteborg Univ. (Sweden). Dept. of General and Marine Microbiology; Boehlmann, W; Fritz, P; Geyer, S; Geyer, W; Hanschman, G; Kopinke, F D; Poerschmann, J [Umweltforschungszentrum Leipzig-Halle (Germany); Chambers, A V; Haworth, A; Ilett, D; Linklater, C M; Tweed, C J [AEA Technology plc, Harwell (United Kingdom); Chenery, S R.N.; Kemp, S J; Milodowski, A E; Pearce, J M; Reeder, S; Rochelle, C A; Smith, B; Wetton, P D; Wragg, J [British Geological Survey, Keyworth (United Kingdom); Clark, I D [Univ. of Ottawa (Canada). Dept. of Geology; Hodginson, E; Hughes, C R [Univ. of Manchester (United Kingdom). Dept. of Earth Sciences; Hyslop, E K [British Geological Survey, Edinburgh (United Kingdom); Karlsson, F [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden); Khoury, H N; Salameh, E [Univ. of Jordan, Amman (Jordan); Lagerblad, B [Cement Inst., Stockholm (Sweden); Longworth, G [Univ. of Manchester (United Kingdom). Dept. of Geology; Pitty, A F [Private consultant, Norwich (United Kingdom); Savage, D [QuantiSci Ltd, Melton Mowbray (United Kingdom); Smellie, J A.T. [ed.; Conterra AB, Uppsala (Sweden)

1998-12-01

This report represents the conclusion to Phase III of the Maqarin Natural Analogue Study. The main thrust was to establish the origin and chemistry of the Western Springs hyper alkaline groundwaters (Na/K enriched Ca(OH){sub 2} type) and to study their interaction with rocks of different compositions, as natural analogues to key processes that might occur at an early stage within the `alkali disturbed zone` of cementitious repositories in different host rocks. Whilst earlier studies at Maqarin were very much site-specific and process-oriented, Phase III provided a regional perspective to the geological evolution of the Maqarin region. This was made possible by greater field access which allowed a more systematic structural and geomorphological study of the area. This has resulted in a greater understanding of the age and spatial relationships concerning formation of the cement zones through spontaneous combustion of the Bituminous Marls, and the subsequent formation of high pH groundwaters at the Eastern and Western Springs locations. At the Western Springs locality, hydrochemical and hydrogeological evaluation of new and published data (plus access to unpublished data), together with detailed mineralogical and geochemical studies, helped to clarify the very earliest stage of cement leachate/host rock interaction. The data were used also to test coupled flow/transport codes developed to assess the long-term evolution of a cementitious repository. Additional objectives addressed include: a) rock matrix diffusion, b) the occurrence and chemical controls on zeolite composition, e) the occurrence and chemical controls on clay stability, and d) the role of microbes, organics and colloids in trace element transport. The Maqarin site now provides a consistent picture explaining the origin of the hyperalkaline groundwaters, and is therefore a unique location for the examination of the mechanisms and processes associated with cementitious repositories. Application of these

Optimized FFTF Acceptance Test Program covering Phases III, IV, and V

International Nuclear Information System (INIS)

Wykoff, W.R.; Jones, D.H.

1977-03-01

A detailed review of Phases III, IV, and V of the FFTF Acceptance Test Program has been completed. The purpose of this review was to formulate that test sequence which not only meets requirements for safe, reliable and useful operation of the plant, but also results in the earliest prudent demonstration of full-power performance. A test sequence based on the underlying assumption that sodium flows into the secondary sodium storage tank (T-44) no later than August 31, 1978, is described in detail. A time-scale which allows extra time to put systems and equipment into operation the first time, debugging, and learning how to operate most effectively has been superimposed on the test sequence. Time is not included for major equipment malfunctions. This test plan provides the basis for coordinating the many and varied activities and interfaces necessary for successful and timely execution of the FFTF Acceptance Test Program. In this report, the need dates have been identified for presently scheduled test articles and standard core components

75 FR 76727 - Evergreen Wind Power III, LLC; Supplemental Notice that Initial Market-Based Rate Filing Includes...

Science.gov (United States)

2010-12-09

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2201-000] Evergreen Wind Power III, LLC; Supplemental Notice that Initial Market-Based Rate Filing Includes Request for... proceeding of Evergreen Wind Power III, LLC's application for market-based rate authority, with an...

Microbial Reducibility of Fe(III Phases Associated with the Genesis of Iron Ore Caves in the Iron Quadrangle, Minas Gerais, Brazil

Directory of Open Access Journals (Sweden)

Ceth W. Parker

2013-11-01

Full Text Available The iron mining regions of Brazil contain thousands of “iron ore caves” (IOCs that form within Fe(III-rich deposits. The mechanisms by which these IOCs form remain unclear, but the reductive dissolution of Fe(III (hydroxides by Fe(III reducing bacteria (FeRB could provide a microbiological mechanism for their formation. We evaluated the susceptibility of Fe(III deposits associated with these caves to reduction by the FeRB Shewanella oneidensis MR-1 to test this hypothesis. Canga, an Fe(III-rich duricrust, contained poorly crystalline Fe(III phases that were more susceptible to reduction than the Fe(III (predominantly hematite associated with banded iron formation (BIF, iron ore, and mine spoil. In all cases, the addition of a humic acid analogue enhanced Fe(III reduction, presumably by shuttling electrons from S. oneidensis to Fe(III phases. The particle size and quartz-Si content of the solids appeared to exert control on the rate and extent of Fe(III reduction by S. oneidensis, with more bioreduction of Fe(III associated with solid phases containing more quartz. Our results provide evidence that IOCs may be formed by the activities of Fe(III reducing bacteria (FeRB, and the rate of this formation is dependent on the physicochemical and mineralogical characteristics of the Fe(III phases of the surrounding rock.

Thermal dewatering of lignite: Phase III - final report

Energy Technology Data Exchange (ETDEWEB)

Champagne, P J; Szladow, A J; Kybett, B D

1981-01-01

Phase III of this project extended the investigation of thermal dewatering on several lignite and peat samples at the temperature range up to 400 degrees C and investigated variables such as retention time, increased rates of heating and cooling, extent of trace element removal, effect of particle size and effect of dewatering under heavy and light oils. Lignites from three areas of Canada (Estevan and Coronach, Saskatchewan, and Onakawana, Ontario) and one peat sample (Garrick, Saskatchewan) were thermally dewatered. The equilibrium moisture values obtained for the dewatered products were as low as, or lower than those obtained in Phases I and II of this project (350 degrees C). However, the measured moisture contents of the thermally dewatered Saskatchewan lignites were somewhat higher than those measured in Phases I and II. The equilibrium moisture values and the moisture contents decreased with increasing temperature. An optimum balance between extent of dewatering and resulting steam pressures is obtained for a dewatering temperature between 300 and 350 degrees C. At these temperatures, residence times in the order of 15 minutes are required. (35 refs.)

Computational Power of Symmetry-Protected Topological Phases.

Science.gov (United States)

Stephen, David T; Wang, Dong-Sheng; Prakash, Abhishodh; Wei, Tzu-Chieh; Raussendorf, Robert

2017-07-07

We consider ground states of quantum spin chains with symmetry-protected topological (SPT) order as resources for measurement-based quantum computation (MBQC). We show that, for a wide range of SPT phases, the computational power of ground states is uniform throughout each phase. This computational power, defined as the Lie group of executable gates in MBQC, is determined by the same algebraic information that labels the SPT phase itself. We prove that these Lie groups always contain a full set of single-qubit gates, thereby affirming the long-standing conjecture that general SPT phases can serve as computationally useful phases of matter.

POPULATION III GAMMA-RAY BURSTS AND BREAKOUT CRITERIA FOR ACCRETION-POWERED JETS

Energy Technology Data Exchange (ETDEWEB)

Nagakura, Hiroki; Suwa, Yudai [Yukawa Institute for Theoretical Physics, Kyoto University, Oiwake-cho, Kitashirakawa, Sakyo-ku, Kyoto 606-8502 (Japan); Ioka, Kunihito, E-mail: hiroki@heap.phys.waseda.ac.jp [KEK Theory Center, 1-1 Oho, Tsukuba 305-0801 (Japan)

2012-08-01

We investigate the propagation of accretion-powered jets in various types of massive stars such as Wolf-Rayet stars, light Population III (Pop III) stars, and massive Pop III stars, all of which are the progenitor candidates of gamma-ray bursts (GRBs). We perform two-dimensional axisymmetric simulations of relativistic hydrodynamics, taking into account both the envelope collapse and the jet propagation (i.e., the negative feedback of the jet on the accretion). Based on our hydrodynamic simulations, we show for the first time that the accretion-powered jet can potentially break out relativistically from the outer layers of Pop III progenitors. In our simulations, the accretion rate is estimated by the mass flux going through the inner boundary, and the jet is injected with a fixed accretion-to-jet conversion efficiency {eta}. By varying the efficiency {eta} and opening angle {theta}{sub op} for more than 40 models, we find that the jet can make a relativistic breakout from all types of progenitors for GRBs if a simple condition {eta} {approx}> 10{sup -4}({theta}{sub op}/8 Degree-Sign ){sup 2} is satisfied, which is consistent with analytical estimates. Otherwise no explosion or some failed spherical explosions occur.

Enhanced Cr(VI) reduction and As(III) oxidation in ice phase: Important role of dissolved organic matter from biochar

Energy Technology Data Exchange (ETDEWEB)

Dong, Xiaoling [Department of Soil and Water Science, University of Florida, Gainesville, FL 32611 (United States); Ma, Lena Q., E-mail: lqma@ufl.edu [State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Jiangsu 210046 (China); Department of Soil and Water Science, University of Florida, Gainesville, FL 32611 (United States); Gress, Julia; Harris, Willie [Department of Soil and Water Science, University of Florida, Gainesville, FL 32611 (United States); Li, Yuncong [Soil and Water Science Department, Tropical Research and Education Center, University of Florida, Homestead, FL 33031-3314 (United States)

2014-02-01

Graphical abstract: - Highlights: • Biochar-derived dissolved organic matter (DOM) effectively reduced Cr(VI) and oxidized As(III). • Cr(VI) and As(III) could serve as a redox couple. • Cr(VI) and As(III) redox conversion was more effective in the ice phase than aqueous phase. • FTIR and ESR showed that biochar DOM served as both electron donor and acceptor. - Abstract: This study evaluated the impact of DOM from two biochars (sugar beet tailing and Brazilian pepper) on Cr(VI) reduction and As(III) oxidation in both ice and aqueous phases with a soil DOM as control. Increasing DOM concentration from 3 to 300 mg C L{sup −1} enhanced Cr(VI) reduction from 20% to 100% and As(III) oxidation from 6.2% to 25%; however, Cr(VI) reduction decreased from 80–86% to negligible while As(III) oxidation increased from negligible to 18–19% with increasing pH from 2 to 10. Electron spin resonance study suggested semiquinone radicals in DOM were involved in As(III) oxidation while Fourier transform infrared analysis suggested that carboxylic groups in DOM participated in both Cr(VI) reduction and As(III) oxidation. During Cr(VI) reduction, part of DOM (∼10%) was oxidized to CO{sub 2}. The enhanced conversion of Cr(VI) and As(III) in the ice phase was due to the freeze concentration effect with elevated concentrations of electron donors and electron acceptors in the grain boundary. Though DOM enhanced both Cr(VI) reduction and As(III)oxidation, Cr(VI) reduction coupled with As(III) oxidation occurred in absence of DOM. The role of DOM, Cr(VI) and/or As(III) in Cr and As transformation may provide new insights into their speciation and toxicity in cold regions.

Firebird-III program description

International Nuclear Information System (INIS)

Lin, M.R.; Prawirosochardjo, S.; Rennick, D.F.; Wessman, E.; Blain, R.J.D.; Wilson, J.M.

1979-09-01

The FIREBIRD-III digital computer program is a general network code developed primarily for predicting the thermalhydraulic behaviour of CANDU power reactors during a postulated loss-of-coolant accident and the subsequent emergency coolant injection. Because of its flexibility, the code can also be used to solve a large variety of general two-phase flow problems. This report describes the thermalhydraulic models and the computation methods used in the program

Remedial Action Report for Operable Units 6-05 and 10-04, Phase III

Energy Technology Data Exchange (ETDEWEB)

R. P. Wells

2007-08-15

This Phase III remedial action report addresses the remediation of lead-contaminated soils found at the Security Training Facility STF-02 Gun Range at the Idaho National Laboratory Site. Phase I, consisting of developing and implementing institutional controls at Operble Unit 10-04 sites and developing and implementing Idaho National Laboratory Site-wide plans for both institutional controls and ecological monitoring, was addressed in a previous report. Phase II will remediate sites contaminated with trinitrotoluene and Royal Demolition Explosive. Phase IV will remediate hazards from unexploded ordnance.

Gas-phase infrared spectrum of phosphorus (III) oxycyanide, OPCN: experimental and theoretical investigations

Science.gov (United States)

Allaf, Abdul. W.; Kassem, M.; Alibrahim, M.; Boustani, Ihsan

1999-03-01

An attempt was made to observe the gas-phase infrared spectrum of Phosphorus (III) oxycyanide, OPCN for the first time. This molecule was produced by an on-line process using phosphorus (III) oxychloride, OPCl as precursor passed over heated AgCN. The products were characterised by the infrared spectra of their vapours. The low resolution gas-phase Fourier transform infrared spectrum shows two bands centered at 2165 and 1385 cm -1. These bands are assigned to, ν1 (CN stretch) and ν2 (OP stretch), respectively. Ab initio self-consistent-field (SCF) molecular orbital (MO) and Møller-Plesset second order perturbation theory (MP2) calculations were performed to determine the geometry, total energy and vibrational frequencies of OPCN.

Analysis of the phase control of the ITER ICRH antenna array. Influence on the load resilience and radiated power spectrum

Energy Technology Data Exchange (ETDEWEB)

Messiaen, A., E-mail: a.messiaen@fz-juelich.de; Ongena, J.; Vervier, M. [Laboratory for Plasma Physics, ERM-KMS, TEC partner, Cycle, B1000-Brussels (Belgium); Swain, D. [US ITER Team, ORNL (United States)

2015-12-10

The paper analyses how the phasing of the ITER ICRH 24 strap array evolves from the power sources up to the strap currents of the antenna. The study of the phasing control and coherence through the feeding circuits with prematching and automatic matching and decoupling network is made by modeling starting from the TOPICA matrix of the antenna array for a low coupling plasma profile and for current drive phasing (worst case for mutual coupling effects). The main results of the analysis are: (i) the strap current amplitude is well controlled by the antinode V{sub max} amplitude of the feeding lines, (ii) the best toroidal phasing control is done by the adjustment of the mean phase of V{sub max} of each poloidal straps column, (iii) with well adjusted system the largest strap current phasing error is ±20°, (iv) the effect on load resilience remains well below the maximum affordable VSWR of the generators, (v) the effect on the radiated power spectrum versus k{sub //} computed by means of the coupling code ANTITER II remains small for the considered cases.

Four-to-one power combiner for 20 GHz phased array antenna using RADC MMIC phase shifters

Science.gov (United States)

1991-01-01

The design and microwave simulation of two-to-one microstrip power combiners is described. The power combiners were designed for use in a four element phase array receive antenna subarray at 20 GHz. Four test circuits are described which were designed to enable testing of the power combiner and the four element phased array antenna. Test Circuit 1 enables measurement of the two-to-one power combiner. Test Circuit 2 enables measurement of the four-to-one power combiner. Test Circuit 3 enables measurement of a four element antenna array without phase shifting MMIC's in order to characterize the power combiner with the antenna patch-to-microstrip coaxial feedthroughs. Test circuit 4 is the four element phased array antenna including the RADC MMIC phase shifters and appropriate interconnects to provide bias voltages and control phase bits.

The majority of patients with metastatic melanoma are not represented in pivotal phase III immunotherapy trials

DEFF Research Database (Denmark)

Donia, Marco; Kimper-Karl, Marie Louise; Høyer, Katrine Lundby

2017-01-01

BACKGROUND: Recent randomised phase III trials have led to the approval of several immune checkpoint inhibitors for unresectable or metastatic melanoma (MM). These trials all employed strict patient selection criteria, and it is currently unknown how large proportion of 'real-world' patients diag...... a huge knowledge gap regarding the usefulness of new immunotherapies in the 'real-world' patient population, and urge additional testing of known regimens in selected poor prognosis cohorts.......BACKGROUND: Recent randomised phase III trials have led to the approval of several immune checkpoint inhibitors for unresectable or metastatic melanoma (MM). These trials all employed strict patient selection criteria, and it is currently unknown how large proportion of 'real-world' patients...... in 2014, were included in the analysis. Seven pre-defined eligibility criteria, all used to select patients for enrolment in five recent randomised phase III immunotherapy trials, were analysed. RESULTS: Fifty-five percent of the total population with MM did not meet one or more eligibility criteria ('not...

The role of technology in reducing health care costs. Phase II and phase III.

Energy Technology Data Exchange (ETDEWEB)

Cilke, John F.; Parks, Raymond C.; Funkhouser, Donald Ray; Tebo, Michael A.; Murphy, Martin D.; Hightower, Marion Michael; Gallagher, Linda K.; Craft, Richard Layne, II; Garcia, Rudy John

2004-04-01

In Phase I of this project, reported in SAND97-1922, Sandia National Laboratories applied a systems approach to identifying innovative biomedical technologies with the potential to reduce U.S. health care delivery costs while maintaining care quality. The effort provided roadmaps for the development and integration of technology to meet perceived care delivery requirements and an economic analysis model for development of care pathway costs for two conditions: coronary artery disease (CAD) and benign prostatic hypertrophy (BPH). Phases II and III of this project, which are presented in this report, were directed at detailing the parameters of telemedicine that influence care delivery costs and quality. These results were used to identify and field test the communication, interoperability, and security capabilities needed for cost-effective, secure, and reliable health care via telemedicine.

Adaptive nonlinear control of single-phase to three-phase UPS system

Directory of Open Access Journals (Sweden)

Kissaoui M.

2014-01-01

Full Text Available This work deals with the problems of uninterruptible power supplies (UPS based on the single-phase to three-phase converters built in two stages: an input bridge rectifier and an output three phase inverter. The two blocks are joined by a continuous intermediate bus. The objective of control is threefold: i power factor correction “PFC”, ii generating a symmetrical three-phase system at the output even if the load is unknown, iii regulating the DC bus voltage. The synthesis of controllers has been reached by two nonlinear techniques that are the sliding mode and adaptive backstepping control. The performances of regulators have been validated by numerical simulation in MATLAB / SIMULINK.

Zwitterion-functionalized polymer microspheres as a sorbent for solid phase extraction of trace levels of V(V), Cr(III), As(III), Sn(IV), Sb(III) and Hg(II) prior to their determination by ICP-MS.

Science.gov (United States)

Jia, Xiaoyu; Gong, Dirong; Zhao, Junyi; Ren, Hongyun; Wang, Jiani; Zhang, Xian

2018-03-19

This paper describes the preparation of zwitterion-functionalized polymer microspheres (ZPMs) and their application to simultaneous enrichment of V(V), Cr(III), As(III), Sn(IV), Sb(III) and Hg(II) from environmental water samples. The ZPMs were prepared by emulsion copolymerization of ethyl methacrylate, 2-diethylaminoethyl methacrylate and triethylene glycol dimethyl acrylate followed by modification with 1,3-propanesultone. The components were analyzed by elemental analyses as well as Fourier transform infrared spectroscopy, and the structures were characterized by scanning electron microscopy and transmission electron microscopy. The ZPMs were packed into a mini-column for on-line solid-phase extraction (SPE) of the above metal ions. Following extraction with 40 mM NH 4 NO 3 and 0.5 M HNO 3 solution, the ions were quantified by ICP-MS. Under the optimized conditions, the enrichment factors (from a 40 mL sample) are up to 60 for the ions V(V), As(III), Sb(III) and Hg(II), and 55 for Cr(III) and Sn(IV). The detection limits are 1.2, 3.4, 1.0, 3.7, 2.1 and 1.6 ng L -1 for V(V), Cr(III), As(III), Sn(IV), Sb(III) and Hg(II), respectively, and the relative standard deviations (RSDs) are below 5.2%. The feasibility and accuracy of the method were validated by successfully analyzing six certified reference materials as well as lake, well and river waters. Graphical abstract Zwitterion-functionalized polymer microspheres (ZPMs) were prepared and packed into a mini-column for on-line solid-phase extraction (SPE) via pump 1. Then V(V), Cr(III), As(III), Sn(IV), Sb(III) and Hg(II) ions in environmental waters were eluted and submitted to ICP-MS via pump 2.

Phase 0 and phase III transport in various organs: combined concept of phases in xenobiotic transport and metabolism.

Science.gov (United States)

Döring, Barbara; Petzinger, Ernst

2014-08-01

The historical phasing concept of drug metabolism and elimination was introduced to comprise the two phases of metabolism: phase I metabolism for oxidations, reductions and hydrolyses, and phase II metabolism for synthesis. With this concept, biological membrane barriers obstructing the accessibility of metabolism sites in the cells for drugs were not considered. The concept of two phases was extended to a concept of four phases when drug transporters were detected that guided drugs and drug metabolites in and out of the cells. In particular, water soluble or charged drugs are virtually not able to overcome the phospholipid membrane barrier. Drug transporters belong to two main clusters of transporter families: the solute carrier (SLC) families and the ATP binding cassette (ABC) carriers. The ABC transporters comprise seven families with about 20 carriers involved in drug transport. All of them operate as pumps at the expense of ATP splitting. Embedded in the former phase concept, the term "phase III" was introduced by Ishikawa in 1992 for drug export by ABC efflux pumps. SLC comprise 52 families, from which many carriers are drug uptake transporters. Later on, this uptake process was referred to as the "phase 0 transport" of drugs. Transporters for xenobiotics in man and animal are most expressed in liver, but they are also present in extra-hepatic tissues such as in the kidney, the adrenal gland and lung. This review deals with the function of drug carriers in various organs and their impact on drug metabolism and elimination.

High Efficiency Quantum Dot III-V Multijunction Solar Cell for Space Power, Phase II

Data.gov (United States)

National Aeronautics and Space Administration — We are proposing to utilize quantum dots to develop a super high-efficiency multijunction III-V solar cell for space. In metamorphic triple junction space solar...

Motivation and participation in a phase III cardiac rehabilitation programme: an application of the health action process approach.

Science.gov (United States)

Dohnke, Birte; Nowossadeck, Enno; Müller-Fahrnow, Werner

2010-10-01

This longitudinal study extends the previous research on low participation rates and high dropout rates in phase III cardiac rehabilitation (CR) exercise programmes. It examines the correlates of motivation and participation 6 months after inpatient phase II CR (T1) and the predictors of dropout 6 months later (T2) using the health action process approach (HAPA). Risk perception, outcome expectancies, self-efficacy, intention (at T1), and participation (at T1 and T2) in relation to phase III CR programmes was assessed in 456 patients. Based on intention and participation at T1, patients were classified as nonintenders (56%), intenders (13%), or actors (31%). Group differences were confirmed in outcome expectancies and self-efficacy. By T2, 21% of T1 actors had dropped out. Dropouts and maintainers differed in intention and self-efficacy (at T1). Results are in line with the HAPA and suggest a perspective for tailoring motivational counselling to improve participation in phase III CR programmes.

Acceptance test procedure, 241-SY-101 Flexible Receiver System, Phase III testing

International Nuclear Information System (INIS)

Ritter, G.A.

1994-01-01

This Acceptance Test Procedure is for the 241-SY-101 Flexible Receiver System, Phase III Testing. This procedure will test the sealing integrity of the Flexible Receiver System to ensure that release of waste and aerosols will be minimized during the removal of the test mixer pump from tank SY-101

Novel concepts for the compression of large volumes of carbon dioxide-phase III

Energy Technology Data Exchange (ETDEWEB)

Moore, J. Jeffrey [Southwest Research Inst., San Antonio, TX (United States); Allison, Timothy C. [Southwest Research Inst., San Antonio, TX (United States); Evans, Neal D. [Southwest Research Inst., San Antonio, TX (United States); Moreland, Brian [Southwest Research Inst., San Antonio, TX (United States); Hernandez, Augusto J. [Southwest Research Inst., San Antonio, TX (United States); Day, Meera [Southwest Research Inst., San Antonio, TX (United States); Ridens, Brandon L. [Southwest Research Inst., San Antonio, TX (United States)

2014-06-30

and tested in a closed loop compressor facility using CO₂ . Both test programs successfully demonstrated good performance and mechanical behavior. In Phase III, a pilot compression plant consisting of a multi-stage centrifugal compressor with cooled diaphragm technology has been designed, constructed, and tested. Comparative testing of adiabatic and cooled tests at equivalent inlet conditions shows that the cooled diaphragms reduce power consumption by 3-8% when the compressor is operated as a back-to-back unit and by up to 9% when operated as a straight-though compressor with no intercooler. The power savings, heat exchanger effectiveness, and temperature drops for the cooled diaphragm were all slightly higher than predicted values but showed the same trends.

Luminescence studies of Sm(III) and Cm(III) complexes in NaSCN/DHDECMP extraction systems

CERN Document Server

Chung, D Y; Kimura, T

1999-01-01

Laser-induced fluorescence (LIF) studies of Sm(III) and Cm(III) complexes in the NaSCN/DHDECMP solvent extraction system were carried out. Luminescence lifetimes were measured to determine the number of water molecules coordinated to Sm(III), Tb(III), Dy(III), and Cm(III) in the sodium thiocyanate solution and in the DHDECMP phase. The hydration number of Sm(III), Tb(III), Dy(III), and Cm(III) in the sodium thiocyanate solution decreased linearly with increasing sodium thiocyanate concentration. The hydration numbers of Sm(III), Dy(III), and Cm(III) in the DHDECMP phase decreased with increasing sodium thiocyanate concentration. The water molecules in the inner coordination sphere of Sm(III) and Dy(III) extracted into the DHDECMP were not completely removed at low sodium thiocyanate concentration but decreased with increasing sodium thiocyanate concentration. However, in the case of Cm(III) extracted into the DHDECMP phase from the sodium thiocyanate solution, there was no water in the inner coordination sphe...

Major faults and troubleshooting for the power generator of Qinshan III

International Nuclear Information System (INIS)

Liu Guangming; Lu Yongfang; Wang Jun

2010-01-01

Generator faults can be sorted into 20 categories, mainly including water leakage, oil leakage, high temperature and short circuit, etc. The paper comprises two sections, the first section emphasizes on typical fault troubleshooting for power generator cooling water leakage, temperature rise and short circuit of Qinshan III, and the second section is conclusion. By expounding the troubleshooting for power generator cooling pipe leakage, -iron-core high temperature and rotor layer short circuit, the repair process and experience in the troubleshooting of typical fault including water leakage, temperature rise and short circuit are described in detail, so as to obtain the overall performance and parameters of the power generator, and provide useful means and plan for future troubleshooting. The paper can make reference to future troubleshooting for power generators. (authors)

Solvent extraction of anionic chelate complexes of lanthanum(III), europium(III), lutetium(III), scandium(III), and indium(III) with 2-thenoyltrifluoroacetone as ion-pairs with tetrabutylammonium ions

International Nuclear Information System (INIS)

Noro, Junji; Sekine, Tatsuya.

1992-01-01

The solvent extraction of lanthanum(III), europium(III), lutetium(III), scandium(III), and indium(III) in 0.1 mol dm -3 sodium nitrate solutions with 2-thenoyltrifluoroacetone (Htta) in the absence and presence of tetrabutylammonium ions (tba + ) into carbon tetrachloride was measured. The extraction of lanthanum(III), europium(III), and lutetium(III) was greatly enhanced by the addition of tba + ; this could be explained in terms of the extraction of a ternary complex, M(tta) 4 - tba + . However, the extractions of scandium(III) and indium(III) were nearly the same when tba + was added. The data were treated on the basis of the formation equilibrium of the ternary complex from the neutral chelate, M(tta) 3 , with the extracted ion-pairs of the reagents, tta - tba + , in the organic phase. It was concluded that the degree of association of M(tta) 3 with the ion-pair, tta - tba + , is greater in the order La(tta) 3 ≅ Eu(tta) 3 > Lu(tta) 3 , or that the stability of the ternary complex in the organic phase is higher in the order La(tta) 4 - tba + ≅ Eu(tta) 4 - tba + > Lu(tta) 4 - tba + . This is similar to those of adduct metal chelates of Htta with tributylphosphate (TBP) in synergistic extraction systems. (author)

Gas-phase infrared spectrum of phosphorus (III) oxycyanide, OPCN: Experimental and theoretical and theoretical investigations

International Nuclear Information System (INIS)

Allaf, A.W.; Kassem, M.; Alibrahim, M.

1999-01-01

An attempt was made to observe the gas-phase infrared spectrum of phosphorus (III) oxycyanide, OPCN for the first time. This molecule was produced by on-line process using phosphorus (III) oxychloride, OPCI as precursor passed over heated Ag CN. The products were characterised by the infrared spectra of their vapours. The low resolution gas-phase Fourier transform infrared spectrum shows two bands at 2165 and 1385 cm -1 . These bands are assigned to ν 1 (C≡N stretch) and ν 2 (O=P stretch), respectively. Ab initio self-consistent-field (SCF) molecular orbital (MO) and Moeller - Plesset second order perturbation theory (MP2) calculations were performed to determine the geometry, total energy and vibrational frequencies of OPCN. (authors)

MECHANICAL CHARACTERISTICS OF THREE-PHASE INDUCTION MOTORS WITH SINGLE-PHASE POWER SUPPLY

Directory of Open Access Journals (Sweden)

V.S. Malyar

2016-06-01

Full Text Available Aim. Development of a method for calculating mechanical characteristics of three-phase induction motors with single-phase power supply. Methods. The developed algorithm is based on the high-adequacy mathematical model of motor and projection method for solving the boundary problem for equations of electrical circuits balance presented in the three-phase coordinate system. As a result of asymmetry of power supply to the stator windings, in steady state, flux-linkage and current change according to the periodic law. They are determined by solving the boundary problem. Results. The developed mathematical model allows determining periodic dependence of coordinates as a function of slip and, based on them, mechanical characteristics of motors. Academic novelty. The developed method relies on a completely new mathematical approach to calculation of stationary modes of nonlinear electromagnetic circuits, which allows obtaining periodic solution in a timeless domain. Practical value. Using the developed calculation algorithm, one can select capacitance required to start an induction motor with single-phase power supply and calculate static mechanical characteristics at a given capacitance.

Lightweight Phase-Change Material For Solar Power

Science.gov (United States)

Stark, Philip

1993-01-01

Lightweight panels containing phase-change materials developed for use as heat-storage elements of compact, lightweight, advanced solar dynamic power system. During high insolation, heat stored in panels via latent heat of fusion of phase-change material; during low insolation, heat withdrawn from panels. Storage elements consist mainly of porous carbon-fiber structures imbued with germanium. Developed for use aboard space station in orbit around Earth, also adapted to lightweight, compact, portable solar-power systems for use on Earth.

INL Results for Phases I and III of the OECD/NEA MHTGR-350 Benchmark

Energy Technology Data Exchange (ETDEWEB)

Gerhard Strydom; Javier Ortensi; Sonat Sen; Hans Hammer

2013-09-01

The Idaho National Laboratory (INL) Very High Temperature Reactor (VHTR) Technology Development Office (TDO) Methods Core Simulation group led the construction of the Organization for Economic Cooperation and Development (OECD) Modular High Temperature Reactor (MHTGR) 350 MW benchmark for comparing and evaluating prismatic VHTR analysis codes. The benchmark is sponsored by the OECD's Nuclear Energy Agency (NEA), and the project will yield a set of reference steady-state, transient, and lattice depletion problems that can be used by the Department of Energy (DOE), the Nuclear Regulatory Commission (NRC), and vendors to assess their code suits. The Methods group is responsible for defining the benchmark specifications, leading the data collection and comparison activities, and chairing the annual technical workshops. This report summarizes the latest INL results for Phase I (steady state) and Phase III (lattice depletion) of the benchmark. The INSTANT, Pronghorn and RattleSnake codes were used for the standalone core neutronics modeling of Exercise 1, and the results obtained from these codes are compared in Section 4. Exercise 2 of Phase I requires the standalone steady-state thermal fluids modeling of the MHTGR-350 design, and the results for the systems code RELAP5-3D are discussed in Section 5. The coupled neutronics and thermal fluids steady-state solution for Exercise 3 are reported in Section 6, utilizing the newly developed Parallel and Highly Innovative Simulation for INL Code System (PHISICS)/RELAP5-3D code suit. Finally, the lattice depletion models and results obtained for Phase III are compared in Section 7. The MHTGR-350 benchmark proved to be a challenging simulation set of problems to model accurately, and even with the simplifications introduced in the benchmark specification this activity is an important step in the code-to-code verification of modern prismatic VHTR codes. A final OECD/NEA comparison report will compare the Phase I and III

Analysis of gas-liquid metal two-phase flows using a reactor safety analysis code SIMMER-III

International Nuclear Information System (INIS)

Suzuki, Tohru; Tobita, Yoshiharu; Kondo, Satoru; Saito, Yasushi; Mishima, Kaichiro

2003-01-01

SIMMER-III, a safety analysis code for liquid-metal fast reactors (LMFRs), includes a momentum exchange model based on conventional correlations for ordinary gas-liquid flows, such as an air-water system. From the viewpoint of safety evaluation of core disruptive accidents (CDAs) in LMFRs, we need to confirm that the code can predict the two-phase flow behaviors with high liquid-to-gas density ratios formed during a CDA. In the present study, the momentum exchange model of SIMMER-III was assessed and improved using experimental data of two-phase flows containing liquid metal, on which fundamental information, such as bubble shapes, void fractions and velocity fields, has been lacking. It was found that the original SIMMER-III can suitably represent high liquid-to-gas density ratio flows including ellipsoidal bubbles as seen in lower gas fluxes. In addition, the employment of Kataoka-Ishii's correlation has improved the accuracy of SIMMER-III for gas-liquid metal flows with cap-shape bubbles as identified in higher gas fluxes. Moreover, a new procedure, in which an appropriate drag coefficient can be automatically selected according to bubble shape, was developed. Through this work, the reliability and the precision of SIMMER-III have been much raised with regard to bubbly flows for various liquid-to-gas density ratios

The third phase of the OECD/NEA TDB project: TDB III

International Nuclear Information System (INIS)

Mompean, F.J.; Illemassene, M.; Perrone, J.

2005-01-01

In 2003 with a foreseen duration of four years. The main objective of this new phase is to extend the existing critically reviewed database for elements of relevance in radioactive waste management, paying attention to the needs of the various national programmes. Following the decision by the Project Management Board (integrated by representatives of 16 organisations with responsibilities in radioactive waste management in 12 OECD member countries) the elements contemplated in this new phase are Th, Sn and Fe, with a higher priority being allocated to inorganic species and compounds. In addition to the corresponding review teams for these elements, an additional expert team has been constituted to prepare guidelines for the evaluation of thermodynamic data for solid solutions. As was the case in TDB Phase II, the basic project review methodology remains unaltered in TDB III. The Figure illustrates the relationship between the various TDB bodies, with an International Organisation, the OECD NEA, acting as Project Coordinator and linking the independent scientific teams and the project governing bodies. This organizational paradigm has proven successful with the recent completion of the five Phase II Reviews (Update, Ni, Se, Zr and Organic Ligands). The review and expert team activities were started in 2004 (except for Fe, being started in 2005) following an initiation stage. This preliminary stage was designed in order to tailor the team compositions to the existing literature for each element. The first reviews stemming from TDB III are scheduled to appear in published form in 2007. The successful completion of these objectives will add three further reports to the current series of nine volumes (dealing with the chemical thermodynamics of U, Np, Pu, Am, Tc, Ni, Se, Zr and compounds and complexes of these elements with oxalate, citrate, EDTA and isa). (authors)

Evaluating Intermittent Androgen-Deprivation Therapy Phase III Clinical Trials: The Devil Is in the Details.

Science.gov (United States)

Hussain, Maha; Tangen, Catherine; Higano, Celestia; Vogelzang, Nicholas; Thompson, Ian

2016-01-20

Intermittent androgen deprivation (IAD) has been widely tested in prostate cancer. However, phase III trials testing continuous androgen deprivation (CAD) versus IAD have reached inconclusive and seemingly contradictory results. Different design and conduct issues must be critically evaluated to better interpret the results. Seven published phase III trials were examined for prespecified design and outcomes. Treatment specifications; primary end point; superiority versus noninferiority design assumptions, including magnitude of assumed versus observed noninferiority margin (NIM); duration of follow-up; and quality-of-life (QOL) outcomes were considered in terms of the results and conclusions reported. Five trials had a superiority and three had a noninferiority primary hypothesis. Only three trials had a uniform population and overall survival (OS) end point. All trials observed better outcomes in terms of OS and progression-free survival (PFS) than assumed at time of study design, translating into prespecified NIMs or hazard ratios that reflected larger absolute differences in OS or PFS between arms. Lower-than-expected event rates also reduced statistical power for the trials. Other factors, including length of follow-up, cause of death, QOL, and primary end point, and their impact on trial interpretation are discussed. No trial to date has demonstrated survival superiority of IAD compared with CAD. Trials concluding IAD is noninferior to CAD were based on wide NIMs that included clinically important survival differences, not likely to be considered comparable by physicians or patients. Interim analyses relying on short follow-up and including a majority of non-prostate cancer deaths will favor a noninferiority conclusion and should be interpreted cautiously. Adequate follow-up is required to ensure capture of prostate cancer deaths in both superiority and noninferiority trials. © 2015 by American Society of Clinical Oncology.

Study of complex formation of cobalt (II) and cobalt (III) in acrylamide aqueous solutions and in the phase of acrylamide hydrogel

International Nuclear Information System (INIS)

Ismailova, M.M.; Egorova, L.A.; Khamidov, B.O.

1993-01-01

Present article is devoted to study of complex formation of cobalt (II) and cobalt (III) in acrylamide aqueous solutions and in the phase of acrylamide hydrogel. The condition of cobalt in various rate of oxidation in acrylamide aqueous solutions was studied. The concentration conditions of stability of system Co(II)-Co(III) were defined. The composition of coordination compounds of cobalt (II) and cobalt (III) in acrylamide aqueous solutions and in the phase of acrylamide hydrogel was determined.

Current status of generation III nuclear power and assessment of AP1000 developed by Westinghouse

International Nuclear Information System (INIS)

Zhang Mingchang

2005-01-01

In order to make greater contributions to the environment, new nuclear power systems will be needed to meet the increase of electricity demand and to replace plants to be decommissioned. A series of new designs, so called Generation III and Generation III +, are being developed to ensure their deployment in a Near-Term Deployment Road-map in US by 2010 and in Europe by 2015. The AP1000, developed by Westinghouse, is a two-loop 1000 MWe PWR with passive safety features and extensive simplifications to enhance its competitiveness in cost and tariff. It is the first Generation III + plant receiving the Final Design Approval by the US NRC. This paper briefly describes AP1000 design features and technical specifications, and presents a more detailed design evaluation with reference to relevant literatures. Both the opportunity and challenges for nuclear power development in China during the first decade of the 21 st century in a historic transition from Gen II to Gen III are analyzed. The key is to balance risks and benefits if the first AP1000 to be settled down in China. (author)

Effects of oxygen plasma treatment power on Aramid fiber III/BMI composite humidity resistance properties

Science.gov (United States)

Wang, Jing; Shi, Chen; Feng, Jiayue; Long, Xi; Meng, Lingzhi; Ren, Hang

2018-01-01

The effects of oxygen plasma treatment power on Aramid Fiber III chemical structure and its reinforced bismaleimides (BMI) composite humidity resistance properties were investigated in this work. The aramid fiber III chemical structure under different plasma treatment power were measured by FTIR. The composite bending strength and interlinear shear strength with different plasma treatment power before and after absorption water were tested respectively. The composite rupture morphology was observed by SEM. The FTIR results showed that oxygen plasma treatment do not change the fiber bulk chemical structure. The composite humidity resistance of bending strength and interlinear shear strength are similar for untreated and plasma treated samples. The retention rate of composite bending strength and interlinear shear strength are about 75% and 94%, respectively. The composite rupture mode turns to be the fiber failure after water absorption.

Encyclopedia of two-phase heat transfer and flow III macro and micro flow boiling and numerical modeling fundamentals

CERN Document Server

2018-01-01

Set III of this encyclopedia is a new addition to the previous Sets I and II. It contains 26 invited chapters from international specialists on the topics of numerical modeling of two-phase flows and evaporation, fundamentals of evaporation and condensation in microchannels and macrochannels, development and testing of micro two-phase cooling systems for electronics, and various special topics (surface wetting effects, microfin tubes, two-phase flow vibration across tube bundles). The chapters are written both by renowned university researchers and by well-known engineers from leading corporate research laboratories. Numerous "must read" chapters cover the fundamentals of research and engineering practice on boiling, condensation and two-phase flows, two-phase heat transfer equipment, electronics cooling systems, case studies and so forth. Set III constitutes a "must have" reference together with Sets I and II for thermal engineering researchers and practitioners.

Imprinted magnetic graphene oxide for the mini-solid phase extraction of Eu (III) from coal mine area

Science.gov (United States)

Patra, Santanu; Roy, Ekta; Madhuri, Rashmi; Sharma, Prashant K.

2017-05-01

The present work represents the preparation of imprinted magnetic reduced graphene oxide and applied it for the selective removal of Eu (III) from local coal mines area. A simple solid phase extraction method was used for this purpose. The material shows a very high adsorption as well as removal efficiency towards Eu (III), which suggest that the material have potential to be used in future for their real time applications in removal of Eu (III) from complex matrices.

Evaluation report on SCTF Core-III test S3-06

International Nuclear Information System (INIS)

Iwamura, Takamichi; Iguchi, Tadashi; Akimoto, Hajime; Okubo, Tsutomu; Ohnuki, Akira; Adachi, Hiromichi; Murao, Yoshio; Minato, Akihiko; Sakaki, Isao.

1988-10-01

In order to investigate the effect of radial power distribution on the thermal-hydraulic characteristics during the reflood phase of a PWR-LOCA with a combined injection type ECCS, a core cooling separate effect test S3-06 and a combined injection test S3-16-Phase 2 were performed using the Slab Core Test Facility (SCTF) Core-III. The radial power distributions in these two tests simulated a reference distribution for a PWR with a combined injection type ECCS and a steep distribution for a PWR with a cold leg injection type ECCS, respectively. Under the radial power distribution of a PWR with a combined injection type ECCS, the radial power distribution had little effect on the thermal-hydraulic behavior in the two-phase up-flow region due to the approximately flat power distribution in this region (power ratio = 1.04 ∼ 1.08). The overall fluid behavior in the pressure vessel was also little affected by the radial power distribution. On the other hand, under the steep radial power distribution (peak power ratio = 1.36), the degree of heat transfer enhancement in high power bundles in the two-phase up-flow region was dominated by the bundlewise radial power ratio as in the case of a PWR with a cold leg injection type ECCS. (author)

A survey of Type III restriction-modification systems reveals numerous, novel epigenetic regulators controlling phase-variable regulons; phasevarions

Science.gov (United States)

Atack, John M; Yang, Yuedong; Jennings, Michael P

2018-01-01

Abstract Many bacteria utilize simple DNA sequence repeats as a mechanism to randomly switch genes on and off. This process is called phase variation. Several phase-variable N6-adenine DNA-methyltransferases from Type III restriction-modification systems have been reported in bacterial pathogens. Random switching of DNA methyltransferases changes the global DNA methylation pattern, leading to changes in gene expression. These epigenetic regulatory systems are called phasevarions — phase-variable regulons. The extent of these phase-variable genes in the bacterial kingdom is unknown. Here, we interrogated a database of restriction-modification systems, REBASE, by searching for all simple DNA sequence repeats in mod genes that encode Type III N6-adenine DNA-methyltransferases. We report that 17.4% of Type III mod genes (662/3805) contain simple sequence repeats. Of these, only one-fifth have been previously identified. The newly discovered examples are widely distributed and include many examples in opportunistic pathogens as well as in environmental species. In many cases, multiple phasevarions exist in one genome, with examples of up to 4 independent phasevarions in some species. We found several new types of phase-variable mod genes, including the first example of a phase-variable methyltransferase in pathogenic Escherichia coli. Phasevarions are a common epigenetic regulation contingency strategy used by both pathogenic and non-pathogenic bacteria. PMID:29554328

Stakeholder perspectives on the use of positron emission tomography in phase III oncology trials in the UK.

Science.gov (United States)

Rojas-Anaya, Hector; Skogen, Karoline; Miles, Kenneth Alan

2012-06-01

To identify factors that influence the use of PET in phase III oncology trials in the UK by evaluating stakeholder perspectives. A wide range of UK PET research stakeholders with a potential interest in the use of PET in phase III trials were identified and invited to participate. These UK PET research stakeholders were consulted using a semistructured questionnaire on their personal experience with and involvement in PET research, the role of PET in phase III oncology clinical trials and on the promotion of UK PET research and unmet clinical needs in oncology. Responses were analysed quantitatively and by qualitative content analysis of free-text responses. A total of 118 responses were received from a wide range of stakeholders representing several professional groups and working environments. Of these respondents, 49 (42%) were using PET in their research. There was the general perception that using PET in clinical research is beneficial in oncology. The two major barriers identified were poor availability of PET and perceived difficulties in funding of excess treatment costs (75% of respondents). Other factors included limited coverage of PET in training, uncertainty about developing imaging protocols or the status of tracers other than 18F-fluorodeoxyglucose, and low awareness of the role of PET in patient selection for therapeutic trials. Patient concerns about radiation were not perceived as a research barrier. Interventions that improve the availability and funding pathways for PET research scans and that increase researcher awareness could help promote the use of PET for phase III oncology trials in the UK.

Radiotherapy in carcinoma of the uterine cervix phase III

Energy Technology Data Exchange (ETDEWEB)

Alvarez Villa, O; Reinerio, A; Felipe Castillo, A; Alonso Pantiga, R; Roig, M

1985-01-01

Between April 1968 and December 1980, 61 patients with phase III cancer of the cervix were treated. Fifty-six of them were squamous-cell carcinomas and five adenocarcinomas. The treatment consisted of a combination of external irradiation at doses varying between 4,000 and 7,000 rads and intracavitary radiotherapy with doses of 4.000 to 6.000 MHz, according to the schemes of the D.M. Anderson of Houston. The results obtained as far as survival is concerned and calculated by the actuarial method were 40% after five and ten years. The local control rate reached was 74%. The severe complications caused by the treatment reached 8.1%.

An extended NSGA-III for solution multi-objective hydro-thermal-wind scheduling considering wind power cost

International Nuclear Information System (INIS)

Yuan, Xiaohui; Tian, Hao; Yuan, Yanbin; Huang, Yuehua; Ikram, Rana M.

2015-01-01

Highlights: • Multi-objective hydro-thermal-wind scheduling model (MO-HTWS) is establish. • The extra cost in MO-HTWS problem caused by wind uncertainty is considered. • An extended NSGA-III is proposed to solve MO-HTWS problem. • Constraint handling strategies are presented to modify infeasible solutions. • The feasibility and effectiveness of the proposed method is verified by example. - Abstract: Due to the characteristics of clean and renewable, wind power is significant to economic and environmental operation of electric power system so that it attracts more and more attention from researchers. This paper integrates wind power with hydrothermal scheduling to establish multi-objective economic emission hydro-thermal-wind scheduling problem (MO-HTWS) model with considering wind uncertain cost. To solve MO-HTWS problem with various complicated constraints, this paper extends NSGA-III by introducing the dominance relationship criterion based on constraint violation to select new generation. Moreover, the constraint handling strategy which repairs the infeasible solutions by modifying the decision variables in feasible zone according to the violation amount is proposed. Finally, a daily scheduling example of hydro-thermal-wind system is used to test the ability of NSGA-III for solving MO-HTWS problem. It is concluded from the superior quality and good distribution of the Pareto optimal solutions that, NSGA-III can offer an efficient alternative for optimizing MO-HTWS problem

Single-crystal neutron diffraction study of ammonium nitrate phase III

International Nuclear Information System (INIS)

Choi, C.S.; Prask, H.J.

1982-01-01

The crystal structure of ammonium nitrate phase III has been studied at room temperature by neutron diffraction using a single crystal containing 5% KNO 3 in solid-solution form. The space group is Pnma, with a = 7.6772 (4), b = 5.8208 (4), c = 7.1396 (5) A, Z = 4. The final residual after full-matrix least-squares refinement was R = 0.042 for 348 observed reflections. The ammonium ions are thermally disordered into two orientations, displaced by an angle of approximately 42 0 about an axis parallel to the c axis. (Auth.)

Kilowatt isotope power system. Phase II plan. Volume I. Phase II program plan

International Nuclear Information System (INIS)

1978-01-01

The development of a Kilowatt Isotope Power System (KIPS) was begun in 1975 for the purpose of satisfying the power requirements of satellites in the 1980's. The KIPS is a 238 PuO 2 -fueled organic Rankine cycle turbine power system to provide a design output of 500 to 2000 W. Phase II of the overall 3-phase KIPS program is described. This volume presents a program plan for qualifying the organic Rankine power system for flight test in 1982. The program plan calls for the design and fabrication of the proposed flight power system; conducting a development and a qualification program including both environmental and endurance testing, using an electrical and a radioisotope heat source; planning for flight test and spacecraft integration; and continuing ground demonstration system testing to act as a flight system breadboard and to accumulate life data

Three Phase Power Imbalance Decomposition into Systematic Imbalance and Random Imbalance

DEFF Research Database (Denmark)

Kong, Wangwei; Ma, Kang; Wu, Qiuwei

2017-01-01

Uneven load allocations and random load behaviors are two major causes for three-phase power imbalance. The former mainly cause systematic imbalance, which can be addressed by low-cost phase swapping; the latter contribute to random imbalance, which requires relatively costly demand...... minimum phase, or both. Then, this paper proposes a new method to decompose three-phase power series into a systematic imbalance component and a random imbalance component as the closed-form solutions of quadratic optimization models that minimize random imbalance. A degree of power imbalance...... is calculated based on the systematic imbalance component to guide phase swapping. Case studies demonstrate that 72.8% of 782 low voltage substations have systematic imbalance components. The degree of power imbalance results reveal the maximum need for phase swapping and the random imbalance components reveal...

Whole Brain Radiotherapy and RRx-001: Two Partial Responses in Radioresistant Melanoma Brain Metastases from a Phase I/II Clinical Trial: A TITE-CRM Phase I/II Clinical Trial.

Science.gov (United States)

Kim, Michelle M; Parmar, Hemant; Cao, Yue; Pramanik, Priyanka; Schipper, Matthew; Hayman, James; Junck, Larry; Mammoser, Aaron; Heth, Jason; Carter, Corey A; Oronsky, Arnold; Knox, Susan J; Caroen, Scott; Oronsky, Bryan; Scicinski, Jan; Lawrence, Theodore S; Lao, Christopher D

2016-04-01

Kim et al. report two patients with melanoma metastases to the brain that responded to treatment with RRx-001 and whole brain radiotherapy (WBRT) without neurologic or systemic toxicity in the context of a phase I/II clinical trial. RRx-001 is an reactive oxygen and reactive nitrogen species (ROS/RNS)-dependent systemically nontoxic hypoxic cell radiosensitizer with vascular normalizing properties under investigation in patients with various solid tumors including those with brain metastases. Metastatic melanoma to the brain is historically associated with poor outcomes and a median survival of 4 to 5 months. WBRT is a mainstay of treatment for patients with multiple brain metastases, but no significant therapeutic advances for these patients have been described in the literature. To date, candidate radiosensitizing agents have failed to demonstrate a survival benefit in patients with brain metastases, and in particular, no agent has demonstrated improved outcome in patients with metastatic melanoma. Kim et al. report two patients with melanoma metastases to the brain that responded to treatment with novel radiosensitizing agent RRx-001 and WBRT without neurologic or systemic toxicity in the context of a phase I/II clinical trial. Published by Elsevier Inc.

Standing phase angle reduction for power system restoration

Energy Technology Data Exchange (ETDEWEB)

Hazarika, D. [Assam Engineering College (India). Electrical Engineering Dept.; Sinha, A.K. [IIT Khargpur (India). Electrical Engineering Dept.

1998-01-01

The paper describes a methodology for the reduction of standing phase angle (SPA) difference between two buses of a power system, which is essential before interconnecting a line between two buses. This problem is encountered normally during restoration operations of a power system. For this purpose, the standing phase angle difference between two specific buses is represented in terms of sensitivity factors associated with the change in real power injections at the buses. To arrive at the desired standing phase angle difference between two buses, the modified contribution at generation/load buses have been evaluated based on 'higher the sensitivity higher the participation' logic. This methodology acts as a direct help to reduce excessive SPA difference between two buses to an acceptable limit, which otherwise requires regulation of various generation levels on a trial and error basis. (author)

Power factor improvement in three-phase networks with unbalanced inductive loads using the Roederstein ESTAmat RPR power factor controller

Science.gov (United States)

Diniş, C. M.; Cunţan, C. D.; Rob, R. O. S.; Popa, G. N.

2018-01-01

The paper presents the analysis of a power factor with capacitors banks, without series coils, used for improving power factor for a three-phase and single-phase inductive loads. In the experimental measurements, to improve the power factor, the Roederstein ESTAmat RPR power factor controller can command up to twelve capacitors banks, while experimenting using only six capacitors banks. Six delta capacitors banks with approximately equal reactive powers were used for experimentation. The experimental measurements were carried out with a three-phase power quality analyser which worked in three cases: a case without a controller with all capacitors banks permanently parallel connected with network, and two other cases with power factor controller (one with setting power factor at 0.92 and the other one at 1). When performing experiments with the power factor controller, a current transformer was used to measure the current on one phase (at a more charged or less loaded phase).

Automatic phase control in solar power satellite systems

Science.gov (United States)

Lindsey, W. C.; Kantak, A. V.

1978-01-01

Various approaches to the problem of generating, maintaining and distributing a coherent, reference phase signal over a large area are suggested, mathematically modeled and analyzed with respect to their ability to minimize: phase build-up, beam diffusion and beam steering phase jitter, cable length, and maximize power transfer efficiency. In addition, phase control configurations are suggested which alleviate the need for layout symmetry.

Safety and hemostatic efficacy of fibrin pad in partial nephrectomy: Results of an open-label Phase I and a randomized, standard-of-care-controlled Phase I/II study

Directory of Open Access Journals (Sweden)

Nativ Ofer

2012-11-01

Full Text Available Abstract Background Bleeding severity, anatomic location, tissue characteristics, and visibility are common challenges encountered while managing intraoperative bleeding, and conventional hemostatic measures (suture, ligature, and cautery may sometimes be ineffective or impractical. While topical absorbable hemostats (TAH are useful hemostatic adjuvants, each TAH has associated disadvantages. Methods We evaluated the safety and hemostatic efficacy of a new advanced biologic combination product―fibrin pad―to potentially address some gaps associated with TAHs. Fibrin pad was assessed as adjunctive hemostat in open partial nephrectomy in single-center, open-label, Phase I study (N = 10, and as primary hemostat in multicenter, single-blind, randomized, standard-of-care (SOC-controlled Phase I/II study (N = 7 in Israel. It was used to control mild-to-moderate bleeding in Phase I and also spurting arterial bleeding in Phase I/II study. Phase I study assessed safety and Phase I/II study, proportion of successes at 10 min following randomization, analyzed by Fisher exact tests at 5% significance level. Results Phase I (N = 10: All patients completed the study. Hemostasis was achieved within 3–4 min (average = 3.1 min of a single application in all patients. Fibrin pad was found to be safe for human use, with no product-related adverse events reported. Phase I/II (N = 7: Hemostatic success at 10 min (primary endpoint was achieved in 3/4 patients treated with fibrin pad versus 0/3 patients treated with SOC. No clinically significant change in laboratory or coagulation parameters was recorded, except a case of post-procedural hemorrhage with fibrin pad, which was considered serious and related to the fibrin pad treatment, and required re-operation. Although Data Safety Monitoring Board authorized trial continuation, the sponsor decided against proceeding toward an indication for primary treatment of severe arterial

THE PHASE REACTOR INDUCTANCE SELECTION TECHNIQUE FOR POWER ACTIVE FILTER

Directory of Open Access Journals (Sweden)

D. V. Tugay

2016-12-01

Full Text Available Purpose. The goal is to develop technique of the phase inductance power reactors selection for parallel active filter based on the account both low-frequency and high-frequency components of the electromagnetic processes in a power circuit. Methodology. We have applied concepts of the electrical circuits theory, vector analysis, mathematical simulation in Matlab package. Results. We have developed a new technique of the phase reactors inductance selection for parallel power active filter. It allows us to obtain the smallest possible value of THD network current. Originality. We have increased accuracy of methods of the phase reactor inductance selection for power active filter. Practical value. The proposed technique can be used in the design and manufacture of the active power filter for real objects of energy supply.

Three-Phase PV CHB Inverter for a Distributed Power Generation System

Directory of Open Access Journals (Sweden)

Pierluigi Guerriero

2016-10-01

Full Text Available This work deals with the design of a three-phase grid-tied photovoltaic (PV cascade H-bridge inverter for distributed power conversion. The power balancing among the phases must be properly addressed. In fact, an intra-phase power imbalance—arising from uneven irradiance and temperature conditions—generates a per-phase power imbalance. This latter can be compensated by the injection of a proper zero-sequence voltage, while the intra-phase balance is ensured by means of a hybrid modulation method which is able to guarantee the handling of unequal DC (Direct Current sources, stable circuit operation, and maximization of PV power production. The digital controller is developed and tested in Matlab/Simulink environment integrated with XSG (Xilinx System Generator, thus allowing an easy transfer on a field-programmable gate array (FPGA platform and accurately describing the behavior of a real hardware implementation. Thus, numerical results have been considered to prove the effectiveness of the proposed approach.

Clinical effects of Angelica dahurica dressing on patients with I-II phase pressure sores.

Science.gov (United States)

Gong, Fen; Niu, Junzhi; Pei, Xing

2016-11-02

Angelica dahurica is a well-known traditional Chinese Medicine (TCM), while little information is available about its effects on pressure sores. We aimed to investigate the clinical effect of Angelica dahurica on patients with I-II phase pressure sores, as well as the underlying mechanism. Patients (n = 98) with phase I and phase II pressure sores were enrolled and randomly assigned to control and treated groups. In addition to holistic nursing, patients in the control group received compound clotrimazole cream, while patients in the treated group received continuous 4 weeks of external application of Angelica dahurica dressing. Therapeutic effect was recorded, along with the levels of interleukin-8 (IL-8), epidermal growth factor (EGF), transforming growth factor (TGF)-β, and vascular endothelial growth factor (VEGF). Besides, HaCaT cells were cultured with different concentrations of Angelica dahurica, and then cell viability, clone formation numbers, cell cycle, and levels of cyclin D1 and cyclin-dependent kinase (CDK) 2 were determined. The total effective rate in the treated group was significantly higher than in the control group. Levels of IL-8, EGF, TGF-β, and VEGF were statistically increased by Angelica dahurica. In addition, the cell viability and clone formation numbers were significantly upregulated by Angelica dahurica in a dose-dependent manner. Also, the percentage of cells in G0/G1 phase, and levels of cyclin D1 and CDK2 were significantly elevated. Our results suggest that Angelica dahurica may provide an effective clinical treatment for I-II phase pressure sores.

Gamma power is phase-locked to posterior alpha activity.

Directory of Open Access Journals (Sweden)

Daria Osipova

Full Text Available Neuronal oscillations in various frequency bands have been reported in numerous studies in both humans and animals. While it is obvious that these oscillations play an important role in cognitive processing, it remains unclear how oscillations in various frequency bands interact. In this study we have investigated phase to power locking in MEG activity of healthy human subjects at rest with their eyes closed. To examine cross-frequency coupling, we have computed coherence between the time course of the power in a given frequency band and the signal itself within every channel. The time-course of the power was calculated using a sliding tapered time window followed by a Fourier transform. Our findings show that high-frequency gamma power (30-70 Hz is phase-locked to alpha oscillations (8-13 Hz in the ongoing MEG signals. The topography of the coupling was similar to the topography of the alpha power and was strongest over occipital areas. Interestingly, gamma activity per se was not evident in the power spectra and only became detectable when studied in relation to the alpha phase. Intracranial data from an epileptic subject confirmed these findings albeit there was slowing in both the alpha and gamma band. A tentative explanation for this phenomenon is that the visual system is inhibited during most of the alpha cycle whereas a burst of gamma activity at a specific alpha phase (e.g. at troughs reflects a window of excitability.

Open-Phase Condition Detecting System for Transformers in Nuclear Power Plant

International Nuclear Information System (INIS)

Ha, Che-Wung; Lee, Do-Hwan

2015-01-01

Recently, several events involving the loss of one of the three phases of the offsite power circuit occurred in the US nuclear power plants (NPPs).. In some cases, the open-phase condition existed undetected for an extended period and in other case, was not properly responded to. Accordingly, the Nuclear Regulatory Commission (NRC) requested all license holders to take corrective actions to address the open-phase condition. It was also requested that all holders or applicant for a standard design certification (DC) include a description of a protection system to detect and separate the open circuit into design control document (DCD). Currently, NPPs including Duke Energy, Exelon, and institutes including Electric Power Research Institute (EPRI) are working together to resolve issues associated with detecting an open-phase condition. This paper, using Electromagnetic Transients Program (EMTP), presents a system to detect and address the loss of one of three phases of the offsite power circuit connected to main, auxiliary and standby transformers, which is hard to be detected in the current protection system. This paper, using EMTP, presents a system to detect and address the loss of one of three phases of the offsite power circuit running to MT, UAT or SAT which is hard to be detected in the current protection system. The system presented in this paper will be useful not only for the KHNP to meet the NRC requirement, but also for nuclear power plants at home and abroad to take corrective actions to provide protection from a single phase open circuit condition for offsite power sources

Open-Phase Condition Detecting System for Transformers in Nuclear Power Plant

Energy Technology Data Exchange (ETDEWEB)

Ha, Che-Wung; Lee, Do-Hwan [KHNP Central Research Institute, Daejeon (Korea, Republic of)

2015-05-15

Recently, several events involving the loss of one of the three phases of the offsite power circuit occurred in the US nuclear power plants (NPPs).. In some cases, the open-phase condition existed undetected for an extended period and in other case, was not properly responded to. Accordingly, the Nuclear Regulatory Commission (NRC) requested all license holders to take corrective actions to address the open-phase condition. It was also requested that all holders or applicant for a standard design certification (DC) include a description of a protection system to detect and separate the open circuit into design control document (DCD). Currently, NPPs including Duke Energy, Exelon, and institutes including Electric Power Research Institute (EPRI) are working together to resolve issues associated with detecting an open-phase condition. This paper, using Electromagnetic Transients Program (EMTP), presents a system to detect and address the loss of one of three phases of the offsite power circuit connected to main, auxiliary and standby transformers, which is hard to be detected in the current protection system. This paper, using EMTP, presents a system to detect and address the loss of one of three phases of the offsite power circuit running to MT, UAT or SAT which is hard to be detected in the current protection system. The system presented in this paper will be useful not only for the KHNP to meet the NRC requirement, but also for nuclear power plants at home and abroad to take corrective actions to provide protection from a single phase open circuit condition for offsite power sources.

Silicon-Carbide (SIC) Multichip Power Modules (MCPMS) For Power Building Block Applications, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — This Small Business Innovation Research Phase I project seeks to prove the feasibility of developing high power density modular power electronic building blocks...

Phasing out nuclear power, the swedish experience

International Nuclear Information System (INIS)

Fredriksson, Y.

2000-01-01

This article presents the chronological steps in the phasing-out of nuclear energy in Sweden. In 1980 a consultative referendum was held and it was decided that: i) no further expansion of nuclear capacity beyond the 12 reactors in operation or already under construction, ii) all nuclear power plants should be decommissioned by the year 2010. In 1988, as a consequence of the Chernobyl nuclear accident, the Swedish parliament decided that one reactor should be closed down in 1995 and a second in 1996. In 1991 the parliament proposed a new energy program for a 5 year period. The main measure was a huge financial support for increasing energy efficiency and for developing environmental sound technologies. At the same time the parliament repealed the 1991 decision of closing 1 reactor in 1995 and made the phase-out process dependent on the results of the new energy policy. In 1994 a parliamentary Commission was appointed to estimate the results of 1991 energy policy. The results were meager and disappointing so the Commission considered that a number of objectives (the climate issue, employment, welfare and competitiveness) remained unresolved if all nuclear power generation should be phased out by 2010. However, the Commission also considered it important to start the phasing-out process at an early stage and stated that one reactor could be closed down without noticeably affecting the power balance. The Barsebaeck reactor is to be closed before the end of november 1999. (A.C.)

Unexpected Relationships and Inbreeding in HapMap Phase III Populations

Science.gov (United States)

Stevens, Eric L.; Baugher, Joseph D.; Shirley, Matthew D.; Frelin, Laurence P.; Pevsner, Jonathan

2012-01-01

Correct annotation of the genetic relationships between samples is essential for population genomic studies, which could be biased by errors or omissions. To this end, we used identity-by-state (IBS) and identity-by-descent (IBD) methods to assess genetic relatedness of individuals within HapMap phase III data. We analyzed data from 1,397 individuals across 11 ethnic populations. Our results support previous studies (Pemberton et al., 2010; Kyriazopoulou-Panagiotopoulou et al., 2011) assessing unknown relatedness present within this population. Additionally, we present evidence for 1,657 novel pairwise relationships across 9 populations. Surprisingly, significant Cotterman's coefficients of relatedness K1 (IBD1) values were detected between pairs of known parents. Furthermore, significant K2 (IBD2) values were detected in 32 previously annotated parent-child relationships. Consistent with a hypothesis of inbreeding, regions of homozygosity (ROH) were identified in the offspring of related parents, of which a subset overlapped those reported in previous studies (Gibson et al. 2010; Johnson et al. 2011). In total, we inferred 28 inbred individuals with ROH that overlapped areas of relatedness between the parents and/or IBD2 sharing at a different genomic locus between a child and a parent. Finally, 8 previously annotated parent-child relationships had unexpected K0 (IBD0) values (resulting from a chromosomal abnormality or genotype error), and 10 previously annotated second-degree relationships along with 38 other novel pairwise relationships had unexpected IBD2 (indicating two separate paths of recent ancestry). These newly described types of relatedness may impact the outcome of previous studies and should inform the design of future studies relying on the HapMap Phase III resource. PMID:23185369

Neuro-diffuse algorithm for neutronic power identification of TRIGA Mark III reactor

International Nuclear Information System (INIS)

Rojas R, E.; Benitez R, J. S.; Segovia de los Rios, J. A.; Rivero G, T.

2009-10-01

In this work are presented the results of design and implementation of an algorithm based on diffuse logic systems and neural networks like method of neutronic power identification of TRIGA Mark III reactor. This algorithm uses the punctual kinetics equation as data generator of training, a cost function and a learning stage based on the descending gradient algorithm allow to optimize the parameters of membership functions of a diffuse system. Also, a series of criteria like part of the initial conditions of training algorithm are established. These criteria according to the carried out simulations show a quick convergence of neutronic power estimated from the first iterations. (Author)

Stability considerations of permanent magnet quadrupoles for CESR phase-III upgrade

Directory of Open Access Journals (Sweden)

W. Lou

1998-06-01

Full Text Available The Cornell electron storage ring (CESR phase-III upgrade plan includes very strong permanent magnet quadrupoles in front of the cryostat for the superconducting quadrupoles and physically as close as possible to the interaction point. Together with the superconducting quadrupoles, they provide tighter vertical focusing at the interaction point. The quadrupoles are built with neodymium iron boron (NdFeB material and operate inside the 15 kG solenoid field. Requirements on the field quality and stability of these quadrupoles are discussed and test results are presented.

Superior outcome of women with stage I/II cutaneous melanoma: Pooled analysis of four European organisation for research and treatment of cancer phase III trials

NARCIS (Netherlands)

A. Joosse (Arjen); S. Collette (Sandra); S. Suciu (Stefan); T.E.C. Nijsten (Tamar); F.J. Lejeune (Ferdy); U.R. Kleeberg (Ulrich); J.W.W. Coebergh (Jan Willem); A.M.M. Eggermont (Alexander); E.G.E. de Vries (Elisabeth)

2012-01-01

textabstractPurpose: Several studies observed a female advantage in the prognosis of cutaneous melanoma, for which behavioral factors or an underlying biologic mechanism might be responsible. Using complete and reliable follow-up data from four phase III trials of the European Organisation for

DECOVALEX - Mathematical models of coupled T-H-M processes for nuclear waste repositories. Report of phase III

International Nuclear Information System (INIS)

Jing, L.; Rutqvist, J.; Stephansson, O.

1995-12-01

This report presents the methodologies and results of the field/laboratory experiments and mathematical modeling defined for the phase III of the project. Results from test cases 2-6 are given in separate chapters of the report (which have been indexed separately), and the last chapter discusses the lessons learned from the three phases of the DECOVALEX project

Three phase active power filter with selective harmonics elimination

Directory of Open Access Journals (Sweden)

Sozański Krzysztof

2016-03-01

Full Text Available This paper describes a three phase shunt active power filter with selective harmonics elimination. The control algorithm is based on a digital filter bank. The moving Discrete Fourier Transformation is used as an analysis filter bank. The correctness of the algorithm has been verified by simulation and experimental research. The paper includes exemplary results of current waveforms and their spectra from a three phase active power filter.

Power coordinated control method with frequency support capability for hybrid single/three-phase microgrid

DEFF Research Database (Denmark)

Zhou, Xiaoping; Chen, Yandong; Zhou, Leming

2018-01-01

storage unit (ESU) are added into hybrid single/three-phase microgrid, and a power coordinated control method with frequency support capability is proposed for hybrid single/three-phase microgrid in this study. PEU is connected with three single-phase microgrids to coordinate power exchange among three...... phases and provide frequency support for hybrid microgrid. Meanwhile, a power coordinated control method based on the droop control is proposed for PEU to alleviate three-phase power imbalance and reduce voltage fluctuation of hybrid microgrid. Besides, ESU is injected into the DC-link to buffer......Due to the intermittent output power of distributed generations (DGs) and the variability of loads, voltage fluctuation and three-phase power imbalance easily occur when hybrid single/three-phase microgrid operates in islanded mode. To address these issues, the power exchange unit (PEU) and energy...

An Application of Graphical Approach to Construct Multiple Testing Procedure in a Hypothetical Phase III Design

Directory of Open Access Journals (Sweden)

Naitee eTing

2014-01-01

Full Text Available Many multiple testing procedures (MTP have been developed in recent years. Among these new procedures, the graphical approach is flexible and easy to communicate with non-statisticians. A hypothetical Phase III clinical trial design is introduced in this manuscript to demonstrate how graphical approach can be applied in clinical product development. In this design, an active comparator is used. It is thought that this test drug under development could potentially be superior to this comparator. For comparison of efficacy, the primary endpoint is well established and widely accepted by regulatory agencies. However, an important secondary endpoint based on Phase II findings looks very promising. The target dose may have a good opportunity to deliver superiority to the comparator. Furthermore, a lower dose is included in case the target dose may demonstrate potential safety concerns. This Phase III study is designed as a non-inferiority trial with two doses, and two endpoints. This manuscript will illustrate how graphical approach is applied to this design in handling multiple testing issues.

CIM5 Phase III base process development results

International Nuclear Information System (INIS)

Witt, D.C.

2000-01-01

Integrated Demonstration Runs for the Am/Cm vitrification process were initiated in the Coupled 5-inch Cylindrical Induction Melter (CIM5) on 11/30/98 and completed on 12/9/98. Four successful runs at 60 wt% lanthanide loading were completed which met or exceeded all established criteria. The operating parameters used in these runs established the base conditions for the 5-inch Cylindrical Induction Melter (CIM5) process and were summarized in the 5-inch CIM design basis, SRT-AMC-99-OO01. (1) In subsequent tests, a total of fourteen CIM5 runs were performed using various power inputs, ramp rates and target temperatures to define the preferred processing conditions (2) Process stability and process flexibility were the key criteria used in assessing the results for each run. A preferred set of operating parameters was defined for the CIM5 batch process and these conditions were used to generate a pre-programmed, automatic processing cycle that was used for the last six CIM.5 runs (3) These operational tests were successfully completed in the January-February time frame and were summarized in SRT-AMC-99-00584. The recommended set of operating conditions defined in Runs No.1 through No.14 was used as the starting point for further pilot system runs to determine the robustness of the process, evaluate a bubbler, and investigate off-normal conditions. CIM5 Phase III Runs No.15 through No.60 were conducted utilizing the pre-programmed, automatic processing cycle to investigate system performance. This report summarizes the results of these tests and provides a recommendation for the base process as well as a processing modification for minimizing volume expansions if americium and/or curium are subject to a thermal reduction reaction like cerium. This document summarizes the results of the base process development tests conducted in the Am/Cm Pilot Facility located in Building 672-T

Review of the Initial Phases of the LHC Power Converter Commissioning

CERN Document Server

Nisbet, D

2008-01-01

The LHC requires more than 1700 power converter systems that supply between 60A and 13kA of precisely regulated current to the superconducting magnets. For the first time at CERN these converters have been installed underground in close proximity to many other accelerator systems. In addition to the power converters themselves, many utilities such as air and water cooling, electrical power, communication networks and magnet safety systems needed to be installed and commissioned as a single system. Due to the complexity of installing and commissioning such a large infrastructure, with inevitable interaction between the different systems, a three phase test strategy was developed. The first phase comprised the manufacture, integration and reception tests of all converter sub-systems necessary for powering. The second phase covered the commissioning of all the power converters installed in their final environment with the utilities. The third phase will add the superconducting magnets and will not be covered by ...

Three-Phase Time-Multiplexed Planar Power Transmission to Distributed Implants.

Science.gov (United States)

Lee, Byunghun; Ahn, Dukju; Ghovanloo, Maysam

2016-03-01

A platform has been presented for wireless powering of receivers (Rx's) that are arbitrarily distributed over a large area. A potential application could be powering of small Rx implants, distributed over large areas of the brain. The transmitter (Tx) consists of three overlapping layers of hexagonal planar spiral coils (hex-PSC) that are horizontally shifted to provide the strongest and most homogeneous electromagnetic flux coverage. The three-layer hex-PSC array is driven by a three-phase time-division-multiplexed power Tx that takes the advantage of the carrier phase shift, coil geometries, and Rx time constant to homogeneously power the arbitrarily distributed Rx's regardless of their misalignments. The functionality of the proposed three-phase power transmission concept has been verified in a detailed scaled-up high-frequency structure simulator Advanced Design System simulation model and measurement setup, and compared with a conventional Tx. The new Tx delivers 5.4 mW to each Rx and achieves, on average, 5.8% power transfer efficiency to the Rx at the worst case 90° angular misalignment, compared with 1.4% by the conventional Tx.

GPS synchronized power system phase angle measurements

Science.gov (United States)

Wilson, Robert E.; Sterlina, Patrick S.

1994-09-01

This paper discusses the use of Global Positioning System (GPS) synchronized equipment for the measurement and analysis of key power system quantities. Two GPS synchronized phasor measurement units (PMU) were installed before testing. It was indicated that PMUs recorded the dynamic response of the power system phase angles when the northern California power grid was excited by the artificial short circuits. Power system planning engineers perform detailed computer generated simulations of the dynamic response of the power system to naturally occurring short circuits. The computer simulations use models of transmission lines, transformers, circuit breakers, and other high voltage components. This work will compare computer simulations of the same event with field measurement.

After Chernobyl. Possibilities of phasing out nuclear power in Sweden

International Nuclear Information System (INIS)

1987-01-01

According to the currently applicable Parliamentary decision, the phasing out of nuclear power in Sweden must be completed by the year 2010. The National Energy Administration has analyzed the following questions. If it were to become evident that operating several or all of the Swedish nuclear power plants entailed serious risks, what possibilities would there be of phasing them out in the short term or over a longer period. And what would the consequences be with regard to the national economy and the environment? First we report the consequences of a rapid phase-out. Here, it is assumed that several or all nuclear plants would be taken out of operation within a period of two years. Available compensatory resources would be limited to more intensive utilization of existing hydropower, back-pressure plants, combined power and heating plants and oil-fired plants. The second alternative is a phase-out in ten years. Moreover, a case is discussed in which phase-out is planned and implemented from 1987 to 2005. Such a plan would provide industry more time to adjust, while a number of alternative techniques and fuels could be used to replace nuclear power. The consequences of the different phase-out alternatives can be described only within a framework of certain assumptions regarding the worldwide development. Important factors here include fuel prices and economic trends. Environmental restrictions comprise another important prerequisite

Conceptual design report for environmental, safety and health phase III FY-91 line item

Energy Technology Data Exchange (ETDEWEB)

NONE

1988-09-01

The Mound Facility (Mound), located in Miamisburg, Ohio, is a Department of Energy (DOE) development and production facility performing support work for DOE`s weapons and energy-related programs. EG&G Mound Applied Technologies (EG&G) is the Operating Contractor (OC) for this Government-Owned, Contractor-Operated (GOCO) facility. The work performed at Mound emphasizes nuclear energy and explosives technology. Mound is currently implementing an Environmental, Safety, and Health (ES&H) Program designed to protect its employees, the public, and the environment from adverse effects caused by the facility`s activities. Design has been completed, and construction is in progress for Phase I of this multiphase program. Phase II has been submitted for fiscal year (FY) 89 funding and Phase IV is being submitted as an FY 92 line item. This Conceptual Design Report (CDR) addresses Phase III of the ES&H program.

Excitation power quantities in phase resonance testing of nonlinear systems with phase-locked-loop excitation

Science.gov (United States)

Peter, Simon; Leine, Remco I.

2017-11-01

Phase resonance testing is one method for the experimental extraction of nonlinear normal modes. This paper proposes a novel method for nonlinear phase resonance testing. Firstly, the issue of appropriate excitation is approached on the basis of excitation power considerations. Therefore, power quantities known from nonlinear systems theory in electrical engineering are transferred to nonlinear structural dynamics applications. A new power-based nonlinear mode indicator function is derived, which is generally applicable, reliable and easy to implement in experiments. Secondly, the tuning of the excitation phase is automated by the use of a Phase-Locked-Loop controller. This method provides a very user-friendly and fast way for obtaining the backbone curve. Furthermore, the method allows to exploit specific advantages of phase control such as the robustness for lightly damped systems and the stabilization of unstable branches of the frequency response. The reduced tuning time for the excitation makes the commonly used free-decay measurements for the extraction of backbone curves unnecessary. Instead, steady-state measurements for every point of the curve are obtained. In conjunction with the new mode indicator function, the correlation of every measured point with the associated nonlinear normal mode of the underlying conservative system can be evaluated. Moreover, it is shown that the analysis of the excitation power helps to locate sources of inaccuracies in the force appropriation process. The method is illustrated by a numerical example and its functionality in experiments is demonstrated on a benchmark beam structure.

Mixed oxide thermal behaviour at BOL: COMETHE III-J models and impact on power-to-melt

International Nuclear Information System (INIS)

Vliet, J. van

1979-01-01

The mixed oxide thermal behaviour at beginning of life is very important because it can impose a limitation to the fuel pin peak power, and therefore to the reactor thermal output. The relevant physical processes leading to fuel restructuring are modelled in COMETHE III-J in a kinetic way. This ensures that the temperature and power history are properly taken into account. These models are described and their impact on the calculated power to melt early in life is analysed. (author)

A new ion imprinted polymer based on Ru(III)-thiobarbituric acid complex for solid phase extraction of ruthenium(III) prior to its determination by ETAAS

International Nuclear Information System (INIS)

Zambrzycka, Elżbieta; Godlewska-Żyłkiewicz, Beata

2014-01-01

A new ruthenium ion imprinted polymer was prepared from the Ru(III) 2-thiobarbituric acid complex (the template), methacrylic acid or acrylamide (the functional monomers), and ethylene glycol dimethacrylate (the cross-linking agent) using 2,2′-azobisisobutyronitrile as the radical initiator. The ion imprinted polymer was characterized and used as a selective sorbent for the solid phase extraction of Ru(III) ions. The effects of type of functional monomer, sample volume, solution pH and flow rate on the extraction efficiency were studied in the dynamic mode. Ru(III) ion was quantitatively retained on the sorbents in the pH range from 3.5 to 10, and can be eluted with 4 mol L−1 aqueous ammonia. The affinity of Ru(III) for the ion imprinted polymer based on the acrylamide monomer is weaker than that for the polymer based on the methacrylic acid monomer, which therefore was used in interference studies and in analytical applications. Following extraction of Ru(III) ions with the imprint and their subsequent elution from the polymer with aqueous ammonia, Ru(III) was detected by electrothermal atomic absorption spectrometry with a detection limit of 0.21 ng mL −1 . The method was successfully applied to the determination of trace amounts of Ru(III) in water, waste, road dust and platinum ore (CRM SARM 76) with a reproducibility (expressed as RSD) below 6.4 %. (author)

Reducing Electromagnetic Interference in a Grid Tied Single Phase Power Inverter

Science.gov (United States)

2016-09-01

With the growing demand for a reliable electrical grid, backup power supplies and energy management systems are a necessity. Systems such as server...ELECTROMAGNETIC INTERFERENCE IN A GRID TIED SINGLE PHASE POWER INVERTER by Jason Hassan Valiani September 2016 Thesis Advisor: Giovanna Oriti...3. REPORT TYPE AND DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE REDUCING ELECTROMAGNETIC INTERFERENCE IN A GRID TIED SINGLE PHASE POWER

Optimal dose selection accounting for patient subpopulations in a randomized Phase II trial to maximize the success probability of a subsequent Phase III trial.

Science.gov (United States)

Takahashi, Fumihiro; Morita, Satoshi

2018-02-08

Phase II clinical trials are conducted to determine the optimal dose of the study drug for use in Phase III clinical trials while also balancing efficacy and safety. In conducting these trials, it may be important to consider subpopulations of patients grouped by background factors such as drug metabolism and kidney and liver function. Determining the optimal dose, as well as maximizing the effectiveness of the study drug by analyzing patient subpopulations, requires a complex decision-making process. In extreme cases, drug development has to be terminated due to inadequate efficacy or severe toxicity. Such a decision may be based on a particular subpopulation. We propose a Bayesian utility approach (BUART) to randomized Phase II clinical trials which uses a first-order bivariate normal dynamic linear model for efficacy and safety in order to determine the optimal dose and study population in a subsequent Phase III clinical trial. We carried out a simulation study under a wide range of clinical scenarios to evaluate the performance of the proposed method in comparison with a conventional method separately analyzing efficacy and safety in each patient population. The proposed method showed more favorable operating characteristics in determining the optimal population and dose.

Pipe Overpack Container Fire Testing: Phase I II & III.

Energy Technology Data Exchange (ETDEWEB)

Figueroa, Victor G. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Ammerman, Douglas J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lopez, Carlos [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gill, Walter [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2018-02-01

The Pipe Overpack Container (POC) was developed at Rocky Flats to transport plutonium residues with higher levels of plutonium than standard transuranic (TRU) waste to the Waste Isolation Pilot Plant (WIPP) for disposal. In 1996 Sandia National Laboratories (SNL) conducted a series of tests to determine the degree of protection POCs provided during storage accident events. One of these tests exposed four of the POCs to a 30-minute engulfing pool fire, resulting in one of the 7A drum overpacks generating sufficient internal pressure to pop off its lid and expose the top of the pipe container (PC) to the fire environment. The initial contents of the POCs were inert materials, which would not generate large internal pressure within the PC if heated. POCs are now being used to store combustible TRU waste at Department of Energy (DOE) sites. At the request of DOE’s Office of Environmental Management (EM) and National Nuclear Security Administration (NNSA), starting in 2015 SNL conducted a series of fire tests to examine whether PCs with combustibles would reach a temperature that would result in (1) decomposition of inner contents and (2) subsequent generation of sufficient gas to cause the PC to over-pressurize and release its inner content. Tests conducted during 2015 and 2016 were done in three phases. The goal of the first phase was to see if the PC would reach high enough temperatures to decompose typical combustible materials inside the PC. The goal of the second test phase was to determine under what heating loads (i.e., incident heat fluxes) the 7A drum lid pops off from the POC drum. The goal of the third phase was to see if surrogate aerosol gets released from the PC when the drum lid is off. This report will describe the various tests conducted in phase I, II, and III, present preliminary results from these tests, and discuss implications for the POCs.

Analog phase lock between two lasers at LISA power levels

International Nuclear Information System (INIS)

Diekmann, Christian; Steier, Frank; Sheard, Benjamin; Heinzel, Gerhard; Danzmann, Karsten

2009-01-01

This paper presents the implementation of an analog optical phase-locked-loop with an offset frequency of about 20MHz between two lasers, where the detected light powers were of the order of 31 pW and 200 μW. The goal of this setup was the design and characterization of a photodiode transimpedance amplifier for application in LISA. By application of a transimpedance amplifier designed to have low noise and low power consumption, the phase noise between the two lasers was a factor of two above the shot noise limit down to 60mHz. The achievable phase sensitivity depends ultimately on the available power of the highly attenuated master laser and on the input current noise of the transimpedance amplifier of the photodetector. The limiting noise source below 60mHz was the analog phase measurement system that was used in this experiment. A digital phase measurement system that is currently under development at the AEI will be used in the near future. Its application should improve the sensitivity.

Analog phase lock between two lasers at LISA power levels

Energy Technology Data Exchange (ETDEWEB)

Diekmann, Christian; Steier, Frank; Sheard, Benjamin; Heinzel, Gerhard; Danzmann, Karsten, E-mail: Christian.Diekmann@aei.mpg.d [Max-Planck-Institute for Gravitational Physics, Callinstr. 38, D-30167 Hannover (Germany)

2009-03-01

This paper presents the implementation of an analog optical phase-locked-loop with an offset frequency of about 20MHz between two lasers, where the detected light powers were of the order of 31 pW and 200 muW. The goal of this setup was the design and characterization of a photodiode transimpedance amplifier for application in LISA. By application of a transimpedance amplifier designed to have low noise and low power consumption, the phase noise between the two lasers was a factor of two above the shot noise limit down to 60mHz. The achievable phase sensitivity depends ultimately on the available power of the highly attenuated master laser and on the input current noise of the transimpedance amplifier of the photodetector. The limiting noise source below 60mHz was the analog phase measurement system that was used in this experiment. A digital phase measurement system that is currently under development at the AEI will be used in the near future. Its application should improve the sensitivity.

Piping engineering for nuclear power plant

International Nuclear Information System (INIS)

Curto, N.; Schmidt, H.; Muller, R.

1988-01-01

In order to develop piping engineering, an adequate dimensioning and correct selection of materials must be secured. A correct selection of materials together with calculations and stress analysis must be carried out with a view to minimizing or avoiding possible failures or damages in piping assembling, which could be caused by internal pressure, weight, temperature, oscillation, etc. The piping project for a nuclear power plant is divided into the following three phases. Phase I: Basic piping design. Phase II: Final piping design. Phase III: Detail engineering. (Author)

Enantiomeric separation of iridium (III) complexes using HPLC chiral stationary phases based on amylose derivatives

International Nuclear Information System (INIS)

Kim, Hee Eun; Seo, Na Hyeon; Hyun, Myung Ho

2016-01-01

Cyclometalated iridium (III) complexes formed with three identical cyclometalating (C-N) ligands (homoleptic) or formed with two cyclometalating (C-N) ligands and one ancillary (LX) ligand (heteroleptic) have been known as highly phosphorescent materials and, thus, they have been utilized as efficient phosphorescent dopants in organic light emitting diodes (OLEDs) 1–3 or as effective phosphorescent chemosensors. 4–7 Cylometalated iridium (III) complexes are chiral compounds consisting of lambda (Λ, left-handed) and delta (Δ, right-handed) isomers. Racemic cyclometa- lated iridium (III) complexes emit light with no net polarization, but optically active cyclometalated iridium (III) complexes emit circularly polarized light. 8,9 Circularly polarized light can be used in various fields including highly efficient three dimensional electronic devices, photo nic devices for optical data storage, biological assays, and others. 8,9 In order to obtain optically active cylometalated iridium (III) complexes and to determine the enantiomeric composition of optically active cylometalated iridium (III) complexes, liquid chromatogr aphic enantiomer separation method on chiral stationary phases (CSPs) has been used. For example, Okamoto and coworkers first reported the high performance liquid chromatographic (HPLC) direct enantiomeric separation of two homoleptic cylometalated iridium (III) complexes on immobilized amylose tris(3,5- dimethylphenylcarbamate) (Chiralpak IA), coated cellulose tris(3,5-dimethylphenylcarbamate) (Chiralc el OD), and coated cellulose tris(4-methylbenzoate) (Chiralce l OJ). 10 Supercritical fluid chromatography (SFC) was also used by Bernhard and coworkers for the enantiomeric separation of cylometalated iridium (III) complexes on coated amylose tris(3,5-dimethylphenylcarbamate) (Chiralpak AD-H). 8 However, the general use of the HPLC method for the direct enantiomeric separation of homoleptic

Enantiomeric separation of iridium (III) complexes using HPLC chiral stationary phases based on amylose derivatives

Energy Technology Data Exchange (ETDEWEB)

Kim, Hee Eun; Seo, Na Hyeon; Hyun, Myung Ho [Dept. of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Busan (Korea, Republic of)

2016-12-15

Cyclometalated iridium (III) complexes formed with three identical cyclometalating (C-N) ligands (homoleptic) or formed with two cyclometalating (C-N) ligands and one ancillary (LX) ligand (heteroleptic) have been known as highly phosphorescent materials and, thus, they have been utilized as efficient phosphorescent dopants in organic light emitting diodes (OLEDs) 1–3 or as effective phosphorescent chemosensors. 4–7 Cylometalated iridium (III) complexes are chiral compounds consisting of lambda (Λ, left-handed) and delta (Δ, right-handed) isomers. Racemic cyclometa- lated iridium (III) complexes emit light with no net polarization, but optically active cyclometalated iridium (III) complexes emit circularly polarized light. 8,9 Circularly polarized light can be used in various fields including highly efficient three dimensional electronic devices, photo nic devices for optical data storage, biological assays, and others. 8,9 In order to obtain optically active cylometalated iridium (III) complexes and to determine the enantiomeric composition of optically active cylometalated iridium (III) complexes, liquid chromatogr aphic enantiomer separation method on chiral stationary phases (CSPs) has been used. For example, Okamoto and coworkers first reported the high performance liquid chromatographic (HPLC) direct enantiomeric separation of two homoleptic cylometalated iridium (III) complexes on immobilized amylose tris(3,5- dimethylphenylcarbamate) (Chiralpak IA), coated cellulose tris(3,5-dimethylphenylcarbamate) (Chiralc el OD), and coated cellulose tris(4-methylbenzoate) (Chiralce l OJ). 10 Supercritical fluid chromatography (SFC) was also used by Bernhard and coworkers for the enantiomeric separation of cylometalated iridium (III) complexes on coated amylose tris(3,5-dimethylphenylcarbamate) (Chiralpak AD-H). 8 However, the general use of the HPLC method for the direct enantiomeric separation of homoleptic.

Symmetrical components and power analysis for a two-phase microgrid system

DEFF Research Database (Denmark)

Alibeik, M.; Santos Jr., E. C. dos; Blaabjerg, Frede

2014-01-01

This paper presents a mathematical model for the symmetrical components and power analysis of a new microgrid system consisting of three wires and two voltages in quadrature, which is designated as a two-phase microgrid. The two-phase microgrid presents the following advantages: 1) constant power...

Portable Thermoelectric Power Generator Coupled with Phase Change Material

Directory of Open Access Journals (Sweden)

Lim Chong C.

2014-07-01

Full Text Available Solar is the intermittent source of renewable energy and all thermal solar systems having a setback on non-functioning during the night and cloudy environment. This paper presents alternative solution for power generation using thermoelectric which is the direct conversion of temperature gradient of hot side and cold side of thermoelectric material to electric voltage. Phase change material with latent heat effect would help to prolong the temperature gradient across thermoelectric material for power generation. Besides, the concept of portability will enable different power source like solar, wasted heat from air conditioner, refrigerator, stove etc, i.e. to create temperature different on thermoelectric material for power generation. Furthermore, thermoelectric will generate direct current which is used by all the gadgets like Smartphone, tablet, laptop etc. The portable concept of renewable energy will encourage the direct usage of renewable energy for portable gadgets. The working principle and design of portable thermoelectric power generator coupled with phase change material is presented in this paper.

Explorations of new phases in the Ga(III)/In(III)-Mo(VI)-Se(IV)/Te(IV)-O systems.

Science.gov (United States)

Kong, Fang; Hu, Chun-Li; Hu, Ting; Zhou, Yong; Mao, Jiang-Gao

2009-07-07

Systematic explorations of new phases in the Ga(III)/In(III)-Mo(VI)-Se(IV)/Te(IV)-O systems by hydrothermal syntheses or solid-state reactions at high-temperature led to four new quaternary compounds, namely, Ga(2)MoQ(2)O(10) (Q = Se, Te), In(2)Mo(2)Se(2)O(13)(H(2)O) and In(2)MoTe(2)O(10). Ga(2)MoQ(2)O(10) (Q = Se, Te) are isostructural and their structures feature a 3D network of gallium selenite/tellurite with 12-member ring tunnels along b-axis, the distorted MoO(6) octahedra are attached on the wall of the above tunnels. The structure of In(2)Mo(2)Se(2)O(13)(H(2)O) features a new pillared-layered architecture composed of 2D indium(III) selenite layers that are interconnected by Mo(2)O(10) dimers, forming 8-membered ring tunnels along the b-axis. The structure of In(2)MoTe(2)O(10) features a 2D indium oxide layer formed by corner- and edge-sharing InO(6) and InO(7) polyhedra with MoO(4) tetrahedra and TeO(n) (n = 4, 5) polyhedra hanging on both sides of the layer, there are weak interlayer Te-O bonds of 2.512 A. Results of optical diffuse reflectance spectrum measurements indicate that all four compounds are insulators, which are in agreement with results of band structure calculations based on DFT methods.

The Impact of a Power Electronics Converter in Phase Failure Work on the Power System Network

Directory of Open Access Journals (Sweden)

Dariusz Zieliński

2016-09-01

Full Text Available The paper presents the impact of phase failure work on power converters. The study includes a three-level NPC inverter (Neutral Point Clamped, controlled by Voltage Oriented Control (VOC. The NPC converter integrates renewable energy sources with the power grid. The article includes a discussion about the causes of phase failure work and an analysis of the converter’s failure and its impact on the power grid. The simulations were performed in MATLAB/Simulink. The study also includes the concept of an integrated protection for IGBTs, controlled by the DSP microprocessor system.

Study on Soft Phase Locked Method to Solving the Synchronization Problem of Active Power Filter in Stand-alone Power Grid

DEFF Research Database (Denmark)

Zhuo, Fang; Wu, Longhui; Chen, Zhe

2009-01-01

on zero-cross detection can't work effectively in small rating stand-alone power grid. Then a soft phase locked loop with additional filter is proposed. It can lock the phase angle on to the positive sequence of fundamental voltage accurately and rapidly. It ensures the performance of APF applied...... in the small rating stand-alone power grid. Moreover, the soft phase locked loop is easy to be implemented in a Digital Signal Processor (DSP). Simulation and experimental results validate that the soft phase locked loop has satisfactory performance.......Traditional LC filters can't work stably in small rating stand-alone power grid. So active power filter (APF) is becoming an important tool to solve the power quality problem in small rating stand-alone power grid. In most current detection algorithm of APF, it needs a synchronizing signal. Firstly...

Power Based Phase-Locked Loop Under Adverse Conditions with Moving Average Filter for Single-Phase System

Directory of Open Access Journals (Sweden)

Menxi Xie

2017-06-01

Full Text Available High performance synchronization methord is citical for grid connected power converter. For single-phase system, power based phase-locked loop(pPLL uses a multiplier as phase detector(PD. As single-phase grid voltage is distorted, the phase error information contains ac disturbances oscillating at integer multiples of fundamental frequency which lead to detection error. This paper presents a new scheme based on moving average filter(MAF applied in-loop of pPLL. The signal characteristic of phase error is dissussed in detail. A predictive rule is adopted to compensate the delay induced by MAF, thus achieving fast dynamic response. In the case of frequency deviate from nomimal, estimated frequency is fed back to adjust the filter window length of MAF and buffer size of predictive rule. Simulation and experimental results show that proposed PLL achieves good performance under adverse grid conditions.

Phase II and III Clinical Studies of Diphtheria-Tetanus-Acellular Pertussis Vaccine Containing Inactivated Polio Vaccine Derived from Sabin Strains (DTaP-sIPV).

Science.gov (United States)

Okada, Kenji; Miyazaki, Chiaki; Kino, Yoichiro; Ozaki, Takao; Hirose, Mizuo; Ueda, Kohji

2013-07-15

Phase II and III clinical studies were conducted to evaluate immunogenicity and safety of a novel DTaP-IPV vaccine consisting of Sabin inactivated poliovirus vaccine (sIPV) and diphtheria-tetanus-acellular pertussis vaccine (DTaP). A Phase II study was conducted in 104 healthy infants using Formulation H of the DTaP-sIPV vaccine containing high-dose sIPV (3, 100, and 100 D-antigen units for types 1, 2, and 3, respectively), and Formulations M and L, containing half and one-fourth of the sIPV in Formulation H, respectively. Each formulation was administered 3 times for primary immunization and once for booster immunization. A Phase III study was conducted in 342 healthy infants who received either Formulation M + oral polio vaccine (OPV) placebo or DTaP + OPV. The OPV or OPV placebo was orally administered twice between primary and booster immunizations. Formulation M was selected as the optimum dose. In the Phase III study, the seropositive rate was 100% for all Sabin strains after primary immunization, and the neutralizing antibody titer after booster immunization was higher than in the control group (DTaP + OPV). All adverse reactions were clinically acceptable. DTaP-sIPV was shown to be a safe and immunogenic vaccine. JapicCTI-121902 for Phase II study, JapicCTI-101075 for Phase III study (http://www.clinicaltrials.jp/user/cte_main.jsp).

ACOUSTIC SCALE FROM THE ANGULAR POWER SPECTRA OF SDSS-III DR8 PHOTOMETRIC LUMINOUS GALAXIES

International Nuclear Information System (INIS)

Seo, Hee-Jong; Ho, Shirley; White, Martin; Reid, Beth; Schlegel, David J.; Cuesta, Antonio J.; Padmanabhan, Nikhil; Ross, Ashley J.; Percival, Will J.; Nichol, Robert C.; Saito, Shun; De Putter, Roland; Eisenstein, Daniel J.; Xu Xiaoying; Skibba, Ramin; Schneider, Donald P.; Verde, Licia; Bizyaev, Dmitry; Brewington, Howard; Brinkmann, J.

2012-01-01

We measure the acoustic scale from the angular power spectra of the Sloan Digital Sky Survey III (SDSS-III) Data Release 8 imaging catalog that includes 872, 921 galaxies over ∼10,000 deg 2 between 0.45 A (z)/r s = 9.212 +0.416 – 0 .404 at z = 0.54, and therefore D A (z) = 1411 ± 65 Mpc at z = 0.54; the result is fairly independent of assumptions on the underlying cosmology. Our measurement of angular diameter distance D A (z) is 1.4σ higher than what is expected for the concordance ΛCDM, in accordance to the trend of other spectroscopic BAO measurements for z ∼> 0.35. We report constraints on cosmological parameters from our measurement in combination with the WMAP7 data and the previous spectroscopic BAO measurements of SDSS and WiggleZ. We refer to our companion papers (Ho et al.; de Putter et al.) for investigations on information of the full power spectrum.

Effects of PECS Phase III Application Training on Independent Mands in Young Children with Autism

Science.gov (United States)

Love, Jessica June

2013-01-01

The purpose of this study was to examine the effects of PECS phase III application training on independent mands in young children with autism. Participants were five children with autism ranging from ages 2 to 4 years old. A multiple baseline across participants was used to evaluate acquisition of independent correct mands across baseline and…

Transient evaluation using EMTP at single open phase with the offsite power transformer for the emergency power supply systems of nuclear power plants

International Nuclear Information System (INIS)

Shimada, Yoshio

2017-01-01

The emergency power supply systems of nuclear power plants, as the objects of this research, are critical in supplying stable electric power to such systems as the emergency core cooling system (ECCS), and in maintaining safety of the nuclear power reactor; this was apparent in the accident at the Fukushima Daiichi Nuclear Power Station. The Nuclear Regulatory Commission (USNRC) issued regulatory documents (BL 2012-011, IN 2012-032), and has commenced evaluations on newly discovered vulnerability in the design of power supply systems which cannot be detected with under-voltage protection relays, with certain kinds of configuration of coils and iron core structures, such as when the offsite power supply side is a Y-connection and the load side is a ⊿-connection etc., when the detection of single open phase fault with the circuit of a transformer which is without a ground fault connected to the offsite power supply system. This report uses simulation by the electro magnetic transients program (EMTP) and clearly describe the response at the time of the power supply single open phase without ground fault for various configuration of coils and various iron core structures of the three-phase transformer, and identify the important issues in the response of emergency power supply systems and the safety related components of representative domestic PWR plants when the single open phase fault occurred without ground fault. This report describes the results of the simulations of operations of the protection relays of the emergency power supply systems and the safety related components of representative a domestic PWR plant with EMTP. This report explains the method to detect open-phase when the transformer is no-load which United States Electric Power Research Institute (EPRI) developed. As the detailed analyses data from EPRI related to the detection method concerned have not been disclosed officially yet, in this paper, the quantitative and detailed verification results

Investor Outlook: Focus on Upcoming LCA2 Gene Therapy Phase III Results.

Science.gov (United States)

Schimmer, Joshua; Breazzano, Steven

2015-09-01

Investor interest in gene therapy has increased substantially over the past few years, and the next major catalyst for the field is likely to be Spark Therapeutics's phase III trial for the treatment of visual impairment caused by RPE65 gene mutations (often referred to as Leber congenital amaurosis type 2, or LCA2, but may include other retinal disorders). Analysis of the approach from the basic genetics, underlying visual mechanisms, clinical data, and commercialization considerations helps frame investor expectations and the potential implications for the broader field.

Three-Phase AC Optimal Power Flow Based Distribution Locational Marginal Price: Preprint

Energy Technology Data Exchange (ETDEWEB)

Yang, Rui; Zhang, Yingchen

2017-05-17

Designing market mechanisms for electricity distribution systems has been a hot topic due to the increased presence of smart loads and distributed energy resources (DERs) in distribution systems. The distribution locational marginal pricing (DLMP) methodology is one of the real-time pricing methods to enable such market mechanisms and provide economic incentives to active market participants. Determining the DLMP is challenging due to high power losses, the voltage volatility, and the phase imbalance in distribution systems. Existing DC Optimal Power Flow (OPF) approaches are unable to model power losses and the reactive power, while single-phase AC OPF methods cannot capture the phase imbalance. To address these challenges, in this paper, a three-phase AC OPF based approach is developed to define and calculate DLMP accurately. The DLMP is modeled as the marginal cost to serve an incremental unit of demand at a specific phase at a certain bus, and is calculated using the Lagrange multipliers in the three-phase AC OPF formulation. Extensive case studies have been conducted to understand the impact of system losses and the phase imbalance on DLMPs as well as the potential benefits of flexible resources.

Characteristics of inversion operation on Fermilab phase controlled pulsed power supplies

International Nuclear Information System (INIS)

Trendler, R.C.

1977-01-01

A well known property of phase controlled rectifiers with pulsed inductive loads is the ability to advance firing angles from full rectification (positive voltage) to full inversion (negative voltage). Though these properties have been effectively used in the Main Ring power supplies, they have not been extensively utilized for beam line magnet power supplies. Modifications to permit advancing phase angle sufficiently to permit inversion were made on TransRex 500 kW power supplies and Ling 55 kW power supplies. The objective of these modifications was to rapidly reduce the current in magnet loads to zero upon command. The modifications required and the performance of the power supplies are discussed

Brayton isotope power system, phase I. Final report

International Nuclear Information System (INIS)

1978-01-01

The Phase I program resulted in the development and ground demonstration of a dynamic power conversion system. The two key contractual objectives of 25% conversion efficiency and 1000 h of endurance testing were successfully met. As a result of the Phase I effort, the BIPS is a viable candidate for further development into a flight system capable of sustained operation in space. It represents the only known dynamic space power system to demonstrate the performance and endurance coupled with the simplicity necessary for reliable operation. This final report follows thirty-five monthly reports. For expediency, it makes liberal use of referenced documents which have been submitted to DOE during the course of the program

A New Power Calculation Method for Single-Phase Grid-Connected Systems

DEFF Research Database (Denmark)

Yang, Yongheng; Blaabjerg, Frede

2013-01-01

A new method to calculate average active power and reactive power for single-phase systems is proposed in this paper. It can be used in different applications where the output active power and reactive power need to be calculated accurately and fast. For example, a grid-connected photovoltaic...... system in low voltage ride through operation mode requires a power feedback for the power control loop. Commonly, a Discrete Fourier Transform (DFT) based power calculation method can be adopted in such systems. However, the DFT method introduces at least a one-cycle time delay. The new power calculation...... method, which is based on the adaptive filtering technique, can achieve a faster response. The performance of the proposed method is verified by experiments and demonstrated in a 1 kW single-phase grid-connected system operating under different conditions.Experimental results show the effectiveness...

Four-branch Star Hybrid Power Filter for Three-phase Four-wire Systems

DEFF Research Database (Denmark)

Blaabjerg, Frede; Teodorescu, Remus; Rodriguez, Pedro

2008-01-01

and derives fundamental concepts about the control of the resulting hybrid power filter. From this analysis, a specifc implementation of a three-phase four-wire hybrid power filter is presented as an illustrative application of the filtering topology. An extensive evaluation using simulation and experimental......This paper presents a new concept for filtering current harmonics in three-phase four-wire networks. The four-branch star (FBS) filtering topology presented in this work is characterized by a particular layout consisting of single-phase inductances and capacitors. Via this layout, a power filter...

Comparison between publicly accessible publications, registries, and protocols of phase III trials indicated persistence of selective outcome reporting.

Science.gov (United States)

Zhang, Sheng; Liang, Fei; Li, Wenfeng

2017-11-01

The decision to make protocols of phase III randomized controlled trials (RCTs) publicly accessible by leading journals was a landmark event in clinical trial reporting. Here, we compared primary outcomes defined in protocols with those in publications describing the trials and in trial registration. We identified phase III RCTs published between January 1, 2012, and June 30, 2015, in The New England Journal of Medicine, The Lancet, The Journal of the American Medical Association, and The BMJ with available protocols. Consistency in primary outcomes between protocols and registries (articles) was evaluated. We identified 299 phase III RCTs with available protocols in this analysis. Out of them, 25 trials (8.4%) had some discrepancy for primary outcomes between publications and protocols. Types of discrepancies included protocol-defined primary outcome reported as nonprimary outcome in publication (11 trials, 3.7%), protocol-defined primary outcome omitted in publication (10 trials, 3.3%), new primary outcome introduced in publication (8 trials, 2.7%), protocol-defined nonprimary outcome reported as primary outcome in publication (4 trials, 1.3%), and different timing of assessment of primary outcome (4 trials, 1.3%). Out of trials with discrepancies in primary outcome, 15 trials (60.0%) had discrepancies that favored statistically significant results. Registration could be seen as a valid surrogate of protocol in 237 of 299 trials (79.3%) with regard to primary outcome. Despite unrestricted public access to protocols, selective outcome reporting persists in a small fraction of phase III RCTs. Only studies from four leading journals were included, which may cause selection bias and limit the generalizability of this finding. Copyright © 2017 Elsevier Inc. All rights reserved.

Phase II and III the next generation of CLS beamline control and data acquisition systems

International Nuclear Information System (INIS)

Matias, E.; Beauregard, D.; Berg, R.; Black, G.; Boots, M.J.; Dolton, W.; Hunter, D.; Igarashi, R.; Liu, D.; Maxwell, D.; Miller, C.D.; Wilson, T.; Wright, G.

2012-01-01

The Canadian Light Source (CLS) is nearing the completion of its suite of Phase II Beamlines and in detailed design of its Phase III Beamlines. The paper presents an overview of the overall approach adopted by CLS in the development of beamline control and data acquisition systems. Building on the experience of our first phase of beamlines the CLS has continued to make extensive use of EPICS with EDM and QT based user interfaces. Increasing interpretive languages such as Python are finding a place in the beamline control systems. Web based environment such as ScienceStudio have also found a prominent place in the control system architecture as we move to tighter integration between data acquisition, visualization and data analysis. (authors)

Phase change energy storage for solar dynamic power systems

Science.gov (United States)

Chiaramonte, F. P.; Taylor, J. D.

1992-01-01

This paper presents the results of a transient computer simulation that was developed to study phase change energy storage techniques for Space Station Freedom (SSF) solar dynamic (SD) power systems. Such SD systems may be used in future growth SSF configurations. Two solar dynamic options are considered in this paper: Brayton and Rankine. Model elements consist of a single node receiver and concentrator, and takes into account overall heat engine efficiency and power distribution characteristics. The simulation not only computes the energy stored in the receiver phase change material (PCM), but also the amount of the PCM required for various combinations of load demands and power system mission constraints. For a solar dynamic power system in low earth orbit, the amount of stored PCM energy is calculated by balancing the solar energy input and the energy consumed by the loads corrected by an overall system efficiency. The model assumes an average 75 kW SD power system load profile which is connected to user loads via dedicated power distribution channels. The model then calculates the stored energy in the receiver and subsequently estimates the quantity of PCM necessary to meet peaking and contingency requirements. The model can also be used to conduct trade studies on the performance of SD power systems using different storage materials.

Novel solid phase extraction procedure for gold(III) on Dowex M 4195 prior to its flame atomic absorption spectrometric determination

International Nuclear Information System (INIS)

Tuzen, Mustafa; Saygi, Kadriye O.; Soylak, Mustafa

2008-01-01

A method for solid phase extraction (SPE) of gold(III) using Dowex M 4195 chelating resin has been developed. The optimum experimental conditions for the quantitative sorption of gold(III), pH, effect of flow rates, eluent types, sorption capacity and the effect of diverse ions on the sorption of gold(III) have been investigated. The chelating resin can be reused for more than 100 cycles of sorption-desorption without any significant change in sorption of gold(III) ions. The recovery values for gold(III) and detection limit (LOD) of gold were greater than 95% and 1.61 μg L -1 , respectively. The preconcentration factor was 31. The relative standard deviation of the method was -1 . The proposed method has been applied for the determination of gold(III) in some real samples including water, soil and sediment samples

Power Loss Calculation and Thermal Modelling for a Three Phase Inverter Drive System

Directory of Open Access Journals (Sweden)

Z. Zhou

2005-12-01

Full Text Available Power losses calculation and thermal modelling for a three-phase inverter power system is presented in this paper. Aiming a long real time thermal simulation, an accurate average power losses calculation based on PWM reconstruction technique is proposed. For carrying out the thermal simulation, a compact thermal model for a three-phase inverter power module is built. The thermal interference of adjacent heat sources is analysed using 3D thermal simulation. The proposed model can provide accurate power losses with a large simulation time-step and suitable for a long real time thermal simulation for a three phase inverter drive system for hybrid vehicle applications.

Evaluation of candidate magnetohydrodynamic materials for the U-02 Phase III test

International Nuclear Information System (INIS)

Marchant, D.D.; Bates, J.L.

1978-06-01

As part of a cooperative U.S.--U.S.S.R. program, electrode and insulator materials tested at the Westinghouse Electrode Systems Test Facility in Pittsburgh, Pennsylvania, were evaluated. From this evaluation materials will be selected for use in the third phase of tests being conducted in the U-02 magnetohydrodynamics test facility in the Soviet Union. Electrode and insulator materials were examined with both an optical microscope and a scanning electron microscope. The cathodes were found to behave differently from the anodes; most notably, the cathodes showed greater potassium interaction. The lanthanum chromite-based electrodes (excluding those fabricated by plasma-spraying) are recommended for testing in the U-02 Phase III test. Hotpressed, fused-grained MgO and sintered MgAl 2 O 4 are recommended as insulator materials. The electrode attachment techniques used in the Westinghouse Tests were inadequate and need to be modified for the U-02 test

Energy market impacts of nuclear power phase-out policies

Energy Technology Data Exchange (ETDEWEB)

Glomsroed, Solveig; Taoyuan, Wei; Mideksa, Torben; Samset, Bjoern H.

2013-03-01

After the Fukushima disaster in March 2011 safety concerns have escalated and policies towards nuclear power are being reconsidered in several countries. This article presents a study of the effect of nuclear power phase-out on regional electricity prices. We consider 4 scenarios with various levels of ambition to scale down the nuclear industry using a multiple region, multiple sector global general equilibrium model. Non-nuclear power production follows the New Policies scenario of the World Energy Outlook (IEA, 2010). Phase-out in Germany and Switzerland increases electricity prices of OECD-Europe moderately by 2-3 per cent early on to 4-5 per cent by 2035 if transmission capacity within the region is sufficient. If all regions shut down old plants built before 2011, North America, OECD-Europe and Japan face increasing electricity prices in the range of 23-28 per cent in 2035. These price increases illustrate the incentives for further investments in renewable electricity or improved technologies in nuclear power production. (Author)

Energy Market Impacts of Nuclear Power Phase-Out Policies

International Nuclear Information System (INIS)

Glomsroed, Solveig; Taoyuan, Wei; Mideksa, Torben; Samset, Bjoern H.

2013-01-01

After the Fukushima disaster in March 2011 safety concerns have escalated and policies towards nuclear power are being reconsidered in several countries. This article presents a study of the effect of nuclear power phase-out on regional electricity prices. We consider 4 scenarios with various levels of ambition to scale down the nuclear industry using a multiple region, multiple sector global general equilibrium model. Non-nuclear power production follows the New Policies scenario of the World Energy Outlook (IEA, 2010). Phase-out in Germany and Switzerland increases electricity prices of OECD-Europe moderately by 2-3 per cent early on to 4-5 per cent by 2035 if transmission capacity within the region is sufficient. If all regions shut down old plants built before 2011, North America, OECD-Europe and Japan face increasing electricity prices in the range of 23-28 per cent in 2035. These price increases illustrate the incentives for further investments in renewable electricity or improved technologies in nuclear power production. (Author)

Investigation of the separation of americium(III) and europium(III) by high-speed countercurrent chromatography

International Nuclear Information System (INIS)

Wu, J.F.; Jin, Y.R.; Xu, Q.C.; Wang, S.L.; Zhang, L.X.

2005-01-01

The long-lived actinides are the important elements in the radioactive waste ;disposal. Because the ions semi diameter and chemical properties of trivalent actinides(III) and trivalent lanthanides(III) are very similar, the separation between them is very difficult. Yang Yu-Sheng put forward the actinides(III) are softer acid than the lanthanides(III), so the actinides(III) are more easily extracted by the soft extractant contain sulfur or nitrogen than the lanthanides(III). Some research have been done on the separation between actinides(III) and lanthanides(III) using the extractants contain sulfur or nitrogen. The results show that satisfactory separation efficiency was gained. Countercurrent Chromatography (CCC) have many specific advantages, such as free from solid support, permit large sample volume and high flow rate, which is useful in the preconcentration of inorganic solute and inorganic preparation. Some studies were done on the separation of lanthanides or-other inorganic elements by HSCCC, the high-purity reagents prepared by HSCCC or CPC turned out to be successful. In present paper, the investigation of separation between Americium (III) and Euricium (III) by High-Speed Countercurrent Chromatography (HSCCC) were made. The extractant used in the work was prepared by ourselves, which is of the soft extractant contrain sulfur. The effects of separation condition on the separation efficiency of Am and Eu by HSCCC were investigated using dichlorophenyl dithiophosphinic acid in xylene as the stationary phase and 0.1 mol/L NaClO4 as mobile phase, respectively. The results show that mutual separation between Am and Eu can be accomplished. The separation factor increases with the increasing of the concentration of extractant and the pH value of the mobile phase, further more, minishing the flow rate of the mobile phase can also improves the separation efficiency between Am and Eu. The nearly base separation was gained when the flow rate is 0.35 ml/min, the

Computational advances in transition phase analysis

International Nuclear Information System (INIS)

Morita, K.; Kondo, S.; Tobita, Y.; Shirakawa, N.; Brear, D.J.; Fischer, E.A.

1994-01-01

In this paper, historical perspective and recent advances are reviewed on computational technologies to evaluate a transition phase of core disruptive accidents in liquid-metal fast reactors. An analysis of the transition phase requires treatment of multi-phase multi-component thermohydraulics coupled with space- and energy-dependent neutron kinetics. Such a comprehensive modeling effort was initiated when the program of SIMMER-series computer code development was initiated in the late 1970s in the USA. Successful application of the latest SIMMER-II in USA, western Europe and Japan have proved its effectiveness, but, at the same time, several areas that require further research have been identified. Based on the experience and lessons learned during the SIMMER-II application through 1980s, a new project of SIMMER-III development is underway at the Power Reactor and Nuclear Fuel Development Corporation (PNC), Japan. The models and methods of SIMMER-III are briefly described with emphasis on recent advances in multi-phase multi-component fluid dynamics technologies and their expected implication on a future reliable transition phase analysis. (author)

Phase-locked, high power, mid-infrared quantum cascade laser arrays

Science.gov (United States)

Zhou, W.; Slivken, S.; Razeghi, M.

2018-04-01

We demonstrate phase-locked, high power quantum cascade laser arrays, which are combined using a monolithic, tree array multimode interferometer, with emission wavelengths around 4.8 μm. A maximum output power of 15 W was achieved from an eight-element laser array, which has only a slightly higher threshold current density and a similar slope efficiency compared to a Fabry-Perot laser of the same length. Calculated multimode interferometer splitting loss is on the order of 0.27 dB for the in-phase supermode. In-phase supermode operation with nearly ideal behavior is demonstrated over the working current range of the array.

Gene expression of transporters and phase I/II metabolic enzymes in murine small intestine during fasting

Directory of Open Access Journals (Sweden)

van der Meijde Jolanda

2007-08-01

Full Text Available Abstract Background Fasting has dramatic effects on small intestinal transport function. However, little is known on expression of intestinal transport and phase I/II metabolism genes during fasting and the role the fatty acid-activated transcription factor PPARα may play herein. We therefore investigated the effects of fasting on expression of these genes using Affymetrix GeneChip MOE430A arrays and quantitative RT-PCR. Results After 24 hours of fasting, expression levels of 33 of the 253 analyzed transporter and phase I/II metabolism genes were changed. Upregulated genes were involved in transport of energy-yielding molecules in processes such as glycogenolysis (G6pt1 and mitochondrial and peroxisomal oxidation of fatty acids (Cact, Mrs3/4, Fatp2, Cyp4a10, Cyp4b1. Other induced genes were responsible for the inactivation of the neurotransmitter serotonin (Sert, Sult1d1, Dtd, Papst2, formation of eicosanoids (Cyp2j6, Cyp4a10, Cyp4b1, or for secretion of cholesterol (Abca1 and Abcg8. Cyp3a11, typically known because of its drug metabolizing capacity, was also increased. Fasting had no pronounced effect on expression of phase II metabolic enzymes, except for glutathione S-transferases which were down-regulated. Time course studies revealed that some genes were acutely regulated, whereas expression of other genes was only affected after prolonged fasting. Finally, we identified 8 genes that were PPARα-dependently upregulated upon fasting. Conclusion We have characterized the response to fasting on expression of transporters and phase I/II metabolic enzymes in murine small intestine. Differentially expressed genes are involved in a variety of processes, which functionally can be summarized as a increased oxidation of fat and xenobiotics, b increased cholesterol secretion, c increased susceptibility to electrophilic stressors, and d reduced intestinal motility. This knowledge increases our understanding of gut physiology, and may be of relevance

Phased Array Focusing for Acoustic Wireless Power Transfer.

Science.gov (United States)

Tseng, Victor Farm-Guoo; Bedair, Sarah S; Lazarus, Nathan

2018-01-01

Wireless power transfer (WPT) through acoustic waves can achieve higher efficiencies than inductive coupling when the distance is above several times the transducer size. This paper demonstrates the use of ultrasonic phased arrays to focus power to receivers at arbitrary locations to increase the power transfer efficiency. Using a phased array consisting of 37 elements at a distance nearly 5 times the receiver transducer diameter, a factor of 2.6 increase in efficiency was achieved when compared to a case equivalent to a single large transducer with the same peak efficiency distance. The array has a total diameter of 7 cm, and transmits through air at 40 kHz to a 1.1-cm diameter receiver, achieving a peak overall efficiency of 4% at a distance of 5 cm. By adjusting the focal distance, the efficiency can also be maintained relatively constant at distances up to 9 cm. Numerical models were developed and shown to closely match the experimental energy transfer behavior; modeling results indicate that the efficiency can be further doubled by increasing the number of elements. For comparison, an inductive WPT system was also built with the diameters of the transmitting and receiving coils equivalent to the dimensions of the transmitting ultrasonic phased array and receiver transducer, and the acoustic WPT system achieved higher efficiencies than the inductive WPT system when the transmit-to-receive distance is above 5 cm. In addition, beam angle steering was demonstrated by using a simplified seven-element 1-D array, achieving power transfer less dependent on receiver placement.

Optical phase dynamics in mutually coupled diode laser systems exhibiting power synchronization

International Nuclear Information System (INIS)

Pal, Vishwa; Ghosh, R; Prasad, Awadhesh

2011-01-01

We probe the physical mechanism behind the known phenomenon of power synchronization of two diode lasers that are mutually coupled via their delayed optical fields. In a diode laser, the amplitude and the phase of the optical field are coupled by the so-called linewidth enhancement factor, α. In this work, we explore the role of optical phases of the electric fields in amplitude (and hence power) synchronization through α in such mutually delay-coupled diode laser systems. Our numerical results show that the synchronization of optical phases drives the powers of lasers to synchronized death regimes. We also find that as α varies for different diode lasers, the system goes through a sequence of in-phase amplitude-death states. Within the windows between successive amplitude-death regions, the cross-correlation between the field amplitudes exhibits a universal power-law behaviour with respect to α.

III-V Ultra-Thin-Body InGaAs/InAs MOSFETs for Low Standby Power Logic Applications

Science.gov (United States)

Huang, Cheng-Ying

As device scaling continues to sub-10-nm regime, III-V InGaAs/InAs metal- oxide-semiconductor ?eld-e?ect transistors (MOSFETs) are promising candidates for replacing Si-based MOSFETs for future very-large-scale integration (VLSI) logic applications. III-V InGaAs materials have low electron effective mass and high electron velocity, allowing higher on-state current at lower VDD and reducing the switching power consumption. However, III-V InGaAs materials have a narrower band gap and higher permittivity, leading to large band-to-band tunneling (BTBT) leakage or gate-induced drain leakage (GIDL) at the drain end of the channel, and large subthreshold leakage due to worse electrostatic integrity. To utilize III-V MOSFETs in future logic circuits, III-V MOSFETs must have high on-state performance over Si MOSFETs as well as very low leakage current and low standby power consumption. In this dissertation, we will report InGaAs/InAs ultra-thin-body MOSFETs. Three techniques for reducing the leakage currents in InGaAs/InAs MOSFETs are reported as described below. 1) Wide band-gap barriers: We developed AlAs0.44Sb0.56 barriers lattice-match to InP by molecular beam epitaxy (MBE), and studied the electron transport in In0.53Ga0.47As/AlAs 0.44Sb0.56 heterostructures. The InGaAs channel MOSFETs using AlAs0.44Sb0.56 bottom barriers or p-doped In0.52 Al0.48As barriers were demonstrated, showing significant suppression on the back barrier leakage. 2) Ultra-thin channels: We investigated the electron transport in InGaAs and InAs ultra-thin quantum wells and ultra-thin body MOSFETs (t ch ~ 2-4 nm). For high performance logic, InAs channels enable higher on-state current, while for low power logic, InGaAs channels allow lower BTBT leakage current. 3) Source/Drain engineering: We developed raised InGaAs and recessed InP source/drain spacers. The raised InGaAs source/drain spacers improve electrostatics, reducing subthreshold leakage, and smooth the electric field near drain, reducing

Challenges in thermal design of industrial single-phase power inverter

Directory of Open Access Journals (Sweden)

Ninković Predrag

2016-01-01

Full Text Available This paper presents the influence of thermal aspects in design process of an industrial single-phase inverter, choice of its topology and components. Stringent design inputs like very high overload level, demand for natural cooling and very wide input voltage range have made conventional circuit topology inappropriate therefore asking for alternative solution. Different power losses calculations in semiconductors are performed and compared, outlining the guidelines how to choose the final topology. Some recommendations in power magnetic components design are given. Based on the final project, a 20kVA single-phase inverter for thermal power plant supervisory and control system is designed and commissioned.

Wireless Power Transmission via Sheet Medium Using Automatic Phase Adjustment of Multiple Inputs

Science.gov (United States)

Matsuda, Takashi; Oota, Toshifumi; Kado, Youiti; Zhang, Bing

The wireless power transmission via sheet medium is a novel physical form of communication that utilizes the surface as a medium to provide both data and power transmission services. To efficiently transmit a relatively-large amount of electric power (several watts), we have developed a wireless power transmission system via sheet medium that concentrates the electric power on a specific spot by using phase control of multiple inputs. However, to find the optimal phases of the multiple inputs making the microwave converge on a specific spot in the sheet medium, the prior knowledge of the device's position, and the pre-experiment measuring the output power, are needed. In wireless communication area, it is known that the retrodirective array scheme can efficiently transmit the power in a self-phasing manner, which uses the pilot signals sent by the client devices. In this paper, we apply the retrodirective array scheme to the wireless power transmission system via sheet medium, and propose a power transmission scheme using the phase-adjustment of multiple inputs. To confirm the effectiveness of the proposal scheme, we evaluate its performance by computer simulation and realistic measurement. Both results show that the proposal scheme can achieve the retrodirectivity over the wireless power transmission via sheet medium.

Chromospheric oscillations observed with OSO 8. III. Average phase spectra for Si II

International Nuclear Information System (INIS)

White, O.R.; Athay, R.G.

1979-01-01

Time series of intensity and Doppler-shift fluctuations in the Si II emission lines lambda816.93 and lambda817.45 are Fourier analyzed to determine the frequency variation of phase differences between intensity and velocity and between these two lines formed 300 km apart in the middle chromosphere. Average phase spectra show that oscillations between 2 and 9 mHz in the two lines have time delays from 35 to 40 s, which is consistent with the upward propagation of sound wave at 8.6-7.5 km s -1 . In this same frequency band near 3 mHz, maximum brightness leads maximum blueshift by 60 0 . At frequencies above 11 mHz where the power spectrum is flat, the phase differences are uncertain, but approximately 65% of the cases indicate upward propagation. At these higher frequencies, the phase lead between intensity and blue Doppler shift ranges from 0 0 to 180 0 with an average value of 90 0 . However, the phase estimates in this upper band are corrupted by both aliasing and randomness inherent to the measured signals. Phase differences in the two narrow spectral features seen at 10.5 and 27 mHz in the power spectra are shown to be consistent with properties expected for aliases of the wheel rotation rate of the spacecraft wheel section

Baseline job satisfaction and stress among pharmacists and pharmacy technicians participating in the Fleetwood Phase III Study.

Science.gov (United States)

Lapane, Kate L; Hughes, Carmel M

2004-11-01

To provide baseline levels of job satisfaction and stress among members of the long-term care pharmacy team participating in the Fleetwood Phase III evaluation. Cross-sectional design; long-term care pharmacy provider in North Carolina (the implementation site of the large-scale Fleetwood Phase III study). All current pharmacy employees as of May/June 2002. None. Health Professional Stress Inventory and job satisfaction. Ninety-four percent (16/17) of consultant pharmacists were satisfied with their job, with 89% reporting they would definitely choose to be a pharmacist again. Seventy-five percent both of dispensing pharmacists and pharmacy technicians reported overall job satisfaction. Forty-one reported that they would not choose to be a pharmacist (pharmacy technician) again. The most frequently reported sources of stress among the dispensing pharmacists and pharmacy technicians were conflicts with non-work obligations (i.e., family, personal life) and the ability to perform duties with short staffing. In addition, inadequate pay and few opportunities for job advancement were often/frequent sources of stress among pharmacy technicians. More than one third of dispensing pharmacists also reported stress frequently because of fears of mistakes in patient treatment. Overall, consultants are very satisfied with their positions, although dispensing pharmacists and pharmacy technicians are less satisfied with their work. The reasons may be because of the different nature of each job, as well as staffing shortages. The extent to which the Fleetwood Model can improve job satisfaction and impact on stress will be evaluated once we resurvey the pharmacy team after the intervention period of the Fleetwood Phase III study.

Development of a central data warehouse for statewide ITS and transportation data in Florida phase III : final report.

Science.gov (United States)

2009-12-15

This report documents Phase III of the development and operation of a prototype for the Statewide Transportation : Engineering Warehouse for Archived Regional Data (STEWARD). It reflects the progress on the development and : operation of STEWARD sinc...

Synthesis, characterization and stability of Cr(III) and Fe(III) hydroxides

International Nuclear Information System (INIS)

Papassiopi, N.; Vaxevanidou, K.; Christou, C.; Karagianni, E.; Antipas, G.S.E.

2014-01-01

Highlights: • Fe(III)–Cr(III) hydroxides enhance groundwater quality better than pure Cr(III) compounds. • Crystalline Cr(OH) 3 ·3H 2 O was unstable, with a solubility higher than 50 μg/l. • Amorphous Cr(OH) 3 (am) was stable with a solubility lower than 50 μg/l in the range 5.7 0.75 Cr 0.25 (OH) 3 , the stability region was extended to 4.8 3 ·xH 2 O whereas in the presence of iron the precipitate is a mixed Fe (1−x) Cr x (OH) 3 phase. In this study, we report on the synthesis, characterisation and stability of mixed (Fe x ,Cr 1−x )(OH) 3 hydroxides as compared to the stability of Cr(OH) 3 . We established that the plain Cr(III) hydroxide, abiding to the approximate molecular formula Cr(OH) 3 ·3H 2 O, was crystalline, highly soluble, i.e. unstable, with a tendency to transform into the stable amorphous hydroxide Cr(OH) 3 (am) phase. Mixed Fe 0.75 Cr 0.25 (OH) 3 hydroxides were found to be of the ferrihydrite structure, Fe(OH) 3 , and we correlated their solubility to that of a solid solution formed by plain ferrihydrite and the amorphous Cr(III) hydroxide. Both our experimental results and thermodynamic calculations indicated that mixed Fe(III)–Cr(III) hydroxides are more effective enhancers of groundwater quality, in comparison to the plain amorphous or crystalline Cr(III) hydroxides, the latter found to have a solubility typically higher than 50 μg/l (maximum EU permitted Cr level in drinking water), while the amorphous Cr(OH) 3 (am) phase was within the drinking water threshold in the range 5.7 0.75 Cr 0.25 (OH) 3 hydroxides studied were of extended stability in the 4.8 < pH < 13.5 range

Lapatinib versus hormone therapy in patients with advanced renal cell carcinoma: a randomized phase III clinical trial

DEFF Research Database (Denmark)

Ravaud, Alain; Hawkins, Robert; Gardner, Jason P

2008-01-01

PURPOSE: Lapatinib is an orally reversible inhibitor of epidermal growth factor receptor (EGFR)/human epidermal growth factor receptor 2 (HER-2) tyrosine kinases with demonstrated activity in patients with HER-2-positive breast cancer. In the current phase III open-label trial, lapatinib was comp...

Space nuclear power plant technology development philosophy for a ground engineering phase

International Nuclear Information System (INIS)

Buden, D.; Trapp, T.J.; Los Alamos National Lab., NM)

1985-01-01

The development of a space qualified nuclear power plant is proceeding from the technical assessment and advancement phase to the ground engineering phase. In this new phase, the selected concept will be matured by the completion of activities needed before protoflight units can be assembled and qualified for first flight applications. This paper addresses a possible philosophy to arrive at the activities to be performed during the ground engineering phase. The philosophy is derived from what we believe a potential user of nuclear power would like to see completed before commitment to a flight development phase. 5 references

Space nuclear power plant technology development philosophy for a ground engineering phase

International Nuclear Information System (INIS)

Buden, D.; Trapp, T.J.

1985-01-01

The development of a space qualified nuclear power plant is proceeding from the Technical Assessment and Advancement Phase to the Ground Engineering Phase. In this new phase, the selected concept will be matured by the completion of activities needed before protoflight units can be assembled and qualified for first flight applications. This paper addresses a possible philosophy to arrive at the activities to be performed during the Ground Engineering Phase. The philosophy is derived from what we believe a potential user of nuclear power would like to see completed before commitment to a flight development phase

Economical effect of nuclear power phase out. Swedish selection and dilemma

International Nuclear Information System (INIS)

Fujime, Kazuya

1999-01-01

Now, it is forecast that the nuclear power plant is not planned its new location except Japan and France among advanced industrial nations, and is fated to phase out at least on its duration year (life). In the ''World Energy Outlook, 1998'' of the International Energy Organization and the International Energy Outlook, 1999 of U.S. Department of Energy, it is also described that both capacities and power generations of nuclear power in the world would reduce after passing their peaks from 2010 to 2020. Dr. W.D. Nord house showed concretely in his ''Swedish Nuclear Dilemma'' that the nuclear power phase out brought a large economical loss to Swedish by a quantitative calculation for a question on if an electric source alternative to nuclear power could be obtained without economical loss. He proposed there that the nuclear power phase out brought a huge economical loss, was inconsistent to global warming prohibition policy, and was adequate to abolish only two out of twelve sets of already defuse determined nuclear power plants. It seems to be necessary to re-examine calmly a result of national vote in 1980, and to revise its orbit to more concrete and actual energy and environment political route. (G.K.)

Instantaneous Power Compensation in Three-Phase Systems by Using p-q-r Theory

DEFF Research Database (Denmark)

Kim, Hyosung; Blaabjerg, Frede; Bak-Jensen, Birgitte

2002-01-01

Three linearly independent instantaneous powers have been defined in the time domain in three-phase four-wire systems with the use of p-q-r theory. Any three-phase circuit can be transformed into three single-phase circuits by the p-q-r transformation Thus the instantaneous powers in any three...

Nature of the Blue-Phase-III endash isotropic critical point: An analogy with the liquid-gas transition

International Nuclear Information System (INIS)

Anisimov, M.A.; Agayan, V.A.; Collings, P.J.

1998-01-01

The analogy with the liquid-gas critical point is analyzed to clarify the nature of the pretransitional behavior of physical properties in the vicinity of the Blue-Phase-III endash isotropic transition in chiral liquid crystalline systems. The analogy is unusual: temperature serves as the ordering field and entropy plays the role of the order parameter. Both mean field and parametric equations of state are formulated in terms of scaling fields. The scaling fields are linear combinations of the physical fields, which are temperature and chirality. It is shown that mixing of the physical field variables naturally leads to a strong asymmetry with respect to the transition temperature in the behavior of the physical properties that cannot be described by simple power laws. While the mean field theory gives a good description of the experimental data, the scaling theory, if one incorporates mixing of the field variables, gives even better agreement with the experimental data, placing this transition in the same universality class as the three-dimensional Ising model. copyright 1998 The American Physical Society

Adaptive fuzzy control of neutron power of the TRIGA Mark III reactor

International Nuclear Information System (INIS)

Rojas R, E.

2014-01-01

The design and implementation of an identification and control scheme of the TRIGA Mark III research nuclear reactor of the Instituto Nacional de Investigaciones Nucleares (ININ) of Mexico is presented in this thesis work. The identification of the reactor dynamics is carried out using fuzzy logic based systems, in which a learning process permits the adjustment of the membership function parameters by means of techniques based on neural networks and bio-inspired algorithms. The resulting identification system is a useful tool that allows the emulation of the reactor power behavior when different types of insertions of reactivity are applied into the core. The identification of the power can also be used for the tuning of the parameters of a control system. On the other hand, the regulation of the reactor power is carried out by means of an adaptive and stable fuzzy control scheme. The control law is derived using the input-output linearization technique, which permits the introduction of a desired power profile for the plant to follow asymptotically. This characteristic is suitable for managing the ascent of power from an initial level n o up to a predetermined final level n f . During the increase of power, a constraint related to the rate of change in power is considered by the control scheme, thus minimizing the occurrence of a safety reactor shutdown due to a low reactor period value. Furthermore, the theory of stability in the sense of Lyapunov is used to obtain a supervisory control law which maintains the power error within a tolerance region, thus guaranteeing the stability of the power of the closed loop system. (Author)

Twenty-seven years of phase III trials for patients with extensive disease small-cell lung cancer: disappointing results.

Directory of Open Access Journals (Sweden)

Isao Oze

Full Text Available BACKGROUND: Few studies have formally assessed whether treatment outcomes have improved substantially over the years for patients with extensive disease small-cell lung cancer (ED-SCLC enrolled in phase III trials. The objective of the current investigation was to determine the time trends in outcomes for the patients in those trials. METHODS AND FINDINGS: We searched for trials that were reported between January 1981 and August 2008. Phase III randomized controlled trials were eligible if they compared first-line, systemic chemotherapy for ED-SCLC. Data were evaluated by using a linear regression analysis. RESULTS: In total, 52 trials were identified that had been initiated between 1980 and 2006; these studies involved 10,262 patients with 110 chemotherapy arms. The number of randomized patients and the proportion of patients with good performance status (PS increased over time. Cisplatin-based regimens, especially cisplatin and etoposide (PE regimen, have increasingly been studied, whereas cyclophosphamide, doxorubicin, and vincristine-based regimens have been less investigated. Multiple regression analysis showed no significant improvement in survival over the years. Additionally, the use of a PE regimen did not affect survival, whereas the proportion of patients with good PS and the trial design of assigning prophylactic cranial irradiation were significantly associated with favorable outcome. CONCLUSIONS AND SIGNIFICANCE: The survival of patients with ED-SCLC enrolled in phase III trials did not improve significantly over the years, suggesting the need for further development of novel targets, newer agents, and comprehensive patient care.

Phased Array Excitations For Efficient Near Field Wireless Power Transmission

Science.gov (United States)

2016-09-01

channeled to the battery or power plant. Figure 2. WPT System Block Diagram for Battery Charging. Source : [2]. Wireless power transfer has gained...EXCITATIONS FOR EFFICIENT NEAR-FIELD WIRELESS POWER TRANSMISSION by Sean X. Hong September 2016 Thesis Advisor: David Jenn Second Reader...TYPE AND DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE PHASED ARRAY EXCITATIONS FOR EFFICIENT NEAR-FIELD WIRELESS POWER TRANSMISSION 5

Trimode optimizes hybrid power plants. Final report: Phase 2

Energy Technology Data Exchange (ETDEWEB)

O`Sullivan, G.A.; O`Sullivan, J.A. [Abacus Controls, Inc., Somerville, NJ (United States)

1998-07-01

In the Phase 2 project, Abacus Controls Inc. did research and development of hybrid systems that combine the energy sources from photovoltaics, batteries, and diesel-generators and demonstrated that they are economically feasible for small power plants in many parts of the world. The Trimode Power Processor reduces the fuel consumption of the diesel-generator to its minimum by presenting itself as the perfect electrical load to the generator. A 30-kW three-phase unit was tested at Sandia National Laboratories to prove its worthiness in actual field conditions. The use of photovoltaics at remote locations where reliability of supply requires a diesel-generator will lower costs to operate by reducing the run time of the diesel generator. The numerous benefits include longer times between maintenance for the diesel engine and better power quality from the generator. 32 figs.

A level III PSA for the inherently safe CAREM-25 nuclear power station

International Nuclear Information System (INIS)

Baron, Jorge H.; Nunez McLeod, J.; Rivera, S.S.

2000-01-01

A Level III PSA has been performed for the inherently safe CAREM-25 nuclear power station, as a requirement for licensing according to argentinian regulations. The CAREM-25 project is still at a detailed design state, therefore only internal events have been considered, and a representative site has been assumed for dose estimations. Several conservative hypothesis have been formulated, but even so an overall core melt frequency of 2.3E -5 per reactor year has been obtained. The risk estimations comply with the regulations. The risk values obtained are compared to the 700MW(e) nuclear power plant Atucha II PSA result, showing an effective risk reduction not only in the severe accident probability but alto in the consequence component of the risk estimation. (author)

Solar central receiver hybrid power system. Phase I study

Energy Technology Data Exchange (ETDEWEB)

None

1978-11-01

A management plan is presented for implementation during the Solar Central Receiver Hybrid Power System - Phase I study project. The project plan and the management controls that will be used to assure technically adequate, timely and cost effective performance of the work required to prepare the designated end products are described. Bechtel in-house controls and those to be used in directing the subcontractors are described. Phase I of the project consists of tradeoff studies, parametric analyses, and engineering studies leading to conceptual definition and evaluation of a commercial hybrid power system that has the potential for supplying economically competitive electric power to a utility grid in the 1985-1990 time frame. The scope also includes the preparation of a development plan for the resolution of technical uncertainties and the preparation of plans and a proposal for Phase II of the program. The technical approach will be based on a central receiver solar energy collection scheme which supplies thermal energy to a combined cycle, generating system, consisting of a gas turbine cycle combined with a steam bottoming cycle by means of a heat recovery steam generator.

Liquid-liquid extraction kinetics of uranyl nitrate and actinides (III)-lanthanides nitrates by extractants with amide function

International Nuclear Information System (INIS)

Toulemonde, V.

1995-01-01

Nowadays, the most important part of electric power is generated by fission energy. But spent fuels have then to be reprocessed. The production of these reprocessed materials separately and with a high purity level is done according to a liquid-liquid extraction process (Purex process) with the use of tributyl phosphate as solvent. Optimization studies concerning the extracting agent have been undertaken. This work gives the results obtained for the uranyl nitrate and the actinides (III)-lanthanides (III) nitrates extraction by extractants with amide function (monoamide for U(VI) and diamide for actinides (III) and lanthanides (III)). The extraction kinetics have been studied in the case of a metallic specie transfer from the aqueous phase towards the organic phase. The experiments show that the nitrates extraction kinetics is limited by the complexation chemical reaction of the species at the interface between the two liquids. An adsorption-desorption interfacial reactional mechanism (Langmuir theory) is proposed for the uranyl nitrate. (O.M.)

200-ZP-1 phase II and III IRM groundwater pump and treat site safety plan

International Nuclear Information System (INIS)

St. John, C.H.

1996-07-01

This safety plan covers operations, maintenance, and support activities related to the 200-ZP-1 Phase II and III Ground Water Pump- and-Treat Facility. The purpose of the facility is to extract carbon tetrachloride contaminated groundwater underlying the ZP-1 Operable Unit; separate the contaminant from the groundwater; and reintroduce the treated water to the aquifer. An air stripping methodology is employed to convert volatile organics to a vapor phase for absorption onto granular activated carbon. The automated process incorporates a variety of process and safety features that shut down the process system in the event that process or safety parameters are exceeded or compromised

Synthesis, characterization and stability of Cr(III) and Fe(III) hydroxides

Energy Technology Data Exchange (ETDEWEB)

Papassiopi, N.; Vaxevanidou, K.; Christou, C.; Karagianni, E.; Antipas, G.S.E., E-mail: gantipas@metal.ntua.gr

2014-01-15

Highlights: • Fe(III)–Cr(III) hydroxides enhance groundwater quality better than pure Cr(III) compounds. • Crystalline Cr(OH){sub 3}·3H{sub 2}O was unstable, with a solubility higher than 50 μg/l. • Amorphous Cr(OH){sub 3}(am) was stable with a solubility lower than 50 μg/l in the range 5.7 < pH < 11. • For mixed Fe{sub 0.75}Cr{sub 0.25}(OH){sub 3}, the stability region was extended to 4.8 < pH < 13.5. -- Abstract: Chromium is a common contaminant of soils and aquifers and constitutes a major environmental problem. In nature, chromium usually exists in the form of two oxidation states, trivalent, Cr(III), which is relatively innocuous for biota and for the aquatic environment, and hexavalent, Cr(VI) which is toxic, carcinogenic and very soluble. Accordingly, the majority of wastewater and groundwater treatment technologies, include a stage where Cr(VI) is reduced to Cr(III), in order to remove chromium from the aqueous phase and bind the element in the form of environmentally stable solid compounds. In the absence of iron the final product is typically of the form Cr(OH){sub 3}·xH{sub 2}O whereas in the presence of iron the precipitate is a mixed Fe{sub (1−x)}Cr{sub x}(OH){sub 3} phase. In this study, we report on the synthesis, characterisation and stability of mixed (Fe{sub x},Cr{sub 1−x})(OH){sub 3} hydroxides as compared to the stability of Cr(OH){sub 3}. We established that the plain Cr(III) hydroxide, abiding to the approximate molecular formula Cr(OH){sub 3}·3H{sub 2}O, was crystalline, highly soluble, i.e. unstable, with a tendency to transform into the stable amorphous hydroxide Cr(OH){sub 3}(am) phase. Mixed Fe{sub 0.75}Cr{sub 0.25}(OH){sub 3} hydroxides were found to be of the ferrihydrite structure, Fe(OH){sub 3}, and we correlated their solubility to that of a solid solution formed by plain ferrihydrite and the amorphous Cr(III) hydroxide. Both our experimental results and thermodynamic calculations indicated that mixed Fe(III)–Cr(III

Direction of Technology Development for Nuclear Power Plants at the O and M Phase

Energy Technology Data Exchange (ETDEWEB)

Jung, Insu; Park, Hwanpyo; Kim, Younghyun [Korea Institute of Construction Technology, Goyang (Korea, Republic of)

2014-05-15

Recently, Korea has attempted to advance overseas markets by securing competitive power in nuclear power technology. In order to develop and operate overall construction management systems with Korea's own brand equipped with sufficient applicability and competitive power in the market abroad and to ensure equal competitive power with other foreign advanced companies of nuclear power plants, Korea has launched a project called 'Data Centric Integration/Automation Technology for NP Project Management System' since July 2011. This project is divided into two phases: the first phase from 2012 to 2016 realizes EPCS stage, and the second phase from 2017 to 2020 extends to O and M stage. Appropriate technology development planning must be established if 'Data Centric Integration/Automation Technology for NP Project Management System' conducted at the first phase would extend to O and M stage at the second phase. Therefore, this study aimed at drawing out the direction of technology development based on present analysis of process at the operational phase of nuclear power plants in Korea conducted as previous study. This study analyzed current operation and maintenance systems first, analyzing the results of differences between the operation process of nuclear plants in Korea which was suggested at the previous study and the process of the Korea Hydro and Nuclear Power Co., Ltd. (hereafter referred to as 'KHNP') and drawing out the direction of technology development for nuclear power plants at the operational phase from the viewpoint of life cycle.

Direction of Technology Development for Nuclear Power Plants at the O and M Phase

International Nuclear Information System (INIS)

Jung, Insu; Park, Hwanpyo; Kim, Younghyun

2014-01-01

Recently, Korea has attempted to advance overseas markets by securing competitive power in nuclear power technology. In order to develop and operate overall construction management systems with Korea's own brand equipped with sufficient applicability and competitive power in the market abroad and to ensure equal competitive power with other foreign advanced companies of nuclear power plants, Korea has launched a project called 'Data Centric Integration/Automation Technology for NP Project Management System' since July 2011. This project is divided into two phases: the first phase from 2012 to 2016 realizes EPCS stage, and the second phase from 2017 to 2020 extends to O and M stage. Appropriate technology development planning must be established if 'Data Centric Integration/Automation Technology for NP Project Management System' conducted at the first phase would extend to O and M stage at the second phase. Therefore, this study aimed at drawing out the direction of technology development based on present analysis of process at the operational phase of nuclear power plants in Korea conducted as previous study. This study analyzed current operation and maintenance systems first, analyzing the results of differences between the operation process of nuclear plants in Korea which was suggested at the previous study and the process of the Korea Hydro and Nuclear Power Co., Ltd. (hereafter referred to as 'KHNP') and drawing out the direction of technology development for nuclear power plants at the operational phase from the viewpoint of life cycle

Development of a single-phase 30 m HTS power cable

Science.gov (United States)

Cho, Jeonwook; Bae, Joon-Han; Kim, Hae-Jong; Sim, Ki-Deok; Kim, Seokho; Jang, Hyun-Man; Lee, Chang-Young; Kim, Dong-Wook

2006-05-01

HTS power transmission cables appear to be the replacement and retrofitting of underground cables in urban areas and HTS power transmission cable offers a number of technical and economic merits compared to the normal conductor cable system. A 30 m long, single-phase 22.9 kV class HTS power transmission cable system has been developed by Korea Electrotechnology Research Institute (KERI), LS Cable Ltd., and Korea Institute of Machinery and Materials (KIMM), which is one of the 21st century frontier project in Korea since 2001. The HTS power cable has been developed, cooled down and tested to obtain realistic thermal and electrical data on HTS power cable system. The evaluation results clarified such good performance of HTS cable that DC critical current of the HTS cable was 3.6 kA and AC loss was 0.98 W/m at 1260 Arms and shield current was 1000 Arms. These results proved the basic properties for 22.9 kV HTS power cable. As a next step, we have been developing a 30 m, three-phase 22.9 kV, 50 MV A HTS power cable system and long term evaluation is in progress now.

Classification of criticality calculations with correlation coefficient method and its application to OECD/NEA burnup credit benchmarks phase III-A and II-A

International Nuclear Information System (INIS)

Okuno, Hiroshi

2003-01-01

A method for classifying benchmark results of criticality calculations according to similarity was proposed in this paper. After formulation of the method utilizing correlation coefficients, it was applied to burnup credit criticality benchmarks Phase III-A and II-A, which were conducted by the Expert Group on Burnup Credit Criticality Safety under auspices of the Nuclear Energy Agency of the Organisation for Economic Cooperation and Development (OECD/NEA). Phase III-A benchmark was a series of criticality calculations for irradiated Boiling Water Reactor (BWR) fuel assemblies, whereas Phase II-A benchmark was a suite of criticality calculations for irradiated Pressurized Water Reactor (PWR) fuel pins. These benchmark problems and their results were summarized. The correlation coefficients were calculated and sets of benchmark calculation results were classified according to the criterion that the values of the correlation coefficients were no less than 0.15 for Phase III-A and 0.10 for Phase II-A benchmarks. When a couple of benchmark calculation results belonged to the same group, one calculation result was found predictable from the other. An example was shown for each of the Benchmarks. While the evaluated nuclear data seemed the main factor for the classification, further investigations were required for finding other factors. (author)

Crosstalk measurement on the D-III neutral beam power supplies

International Nuclear Information System (INIS)

Nerm, A.; Bowles, E.; Callis, R.W.; Colleraine, A.; Cowels, G.; Finizio, R.; Moore, D.; Tooker, J.F.; Varga, H.

1983-01-01

The Doublet III neutral beam plasma heating system comprises three beamlines with a total of six ion sources. Each of these ion sources is energized from a Neutral Beam Power System (NBPS) which is capable of delivering pulses at 80 kV and 100 A with pulse lengths up to 1 second in duration. A 138 kV San Diego Gas and Electric Company line is used as the prime power source for the NBPS. The 138 kV line is stepped down through an 84 MVA (pulse rating) 138 kV-12.47 kV transformer and an 8 MVA (pulse rating) 138 kV--480 V transformer. The 12.47 kV transformer feeds six NBPS high voltage circuits. The 480 V transformer supplies power to the filament, arc, and auxiliary power systems and control consoles in each NBPS. Each of the NBPS may block (controlled interruption of NBPS to protect the ion source) several times during a shot. Voltage variations due to such blocking by one or more systems have been measured on the 12.47 kV distribution bus as part of an effort to reduce system interaction. Interaction due to blocking during shots was found to be caused by noise picked up in low level circuits during ion source faults. High voltage DC fluctuations due to blocking do not cause interaction unless the voltage sags below the minimum required anode voltage for the pulse tetrodes in the Modular/Regulator, but interaction due to crowbar of the high voltage DC supply by a NBPS may result in a domino effect unless the remaining online systems are caused to block until the crowbarred system is cleared from the line (This feature is not presently implemented.). Voltage sag on the 480 V bus results from simultaneous operation of the ion sources. This sag, when it occurs, may lower the arc power input to the ion sources and cause reduced output power

Novel solid phase extraction procedure for gold(III) on Dowex M 4195 prior to its flame atomic absorption spectrometric determination

Energy Technology Data Exchange (ETDEWEB)

Tuzen, Mustafa [Gaziosmanpasa University, Faculty of Science and Arts, Chemistry Department, 60250 Tokat (Turkey)], E-mail: mtuzen@gop.edu.tr; Saygi, Kadriye O. [Gaziosmanpasa University, Faculty of Science and Arts, Chemistry Department, 60250 Tokat (Turkey); Soylak, Mustafa [Erciyes University, Faculty of Science and Arts, Chemistry Department, 38039 Kayseri (Turkey)

2008-08-15

A method for solid phase extraction (SPE) of gold(III) using Dowex M 4195 chelating resin has been developed. The optimum experimental conditions for the quantitative sorption of gold(III), pH, effect of flow rates, eluent types, sorption capacity and the effect of diverse ions on the sorption of gold(III) have been investigated. The chelating resin can be reused for more than 100 cycles of sorption-desorption without any significant change in sorption of gold(III) ions. The recovery values for gold(III) and detection limit (LOD) of gold were greater than 95% and 1.61 {mu}g L{sup -1}, respectively. The preconcentration factor was 31. The relative standard deviation of the method was <5%. The adsorption capacity of the resin was 8.1 mg g{sup -1}. The proposed method has been applied for the determination of gold(III) in some real samples including water, soil and sediment samples.

Single-Phase Single-Stage Grid Tied Solar PV System with Active Power Filtering Using Power Balance Theory

Science.gov (United States)

Singh, Yashi; Hussain, Ikhlaq; Singh, Bhim; Mishra, Sukumar

2018-03-01

In this paper, power quality features such as harmonics mitigation, power factor correction with active power filtering are addressed in a single-stage, single-phase solar photovoltaic (PV) grid tied system. The Power Balance Theory (PBT) with perturb and observe based maximum power point tracking algorithm is proposed for the mitigation of power quality problems in a solar PV grid tied system. The solar PV array is interfaced to a single phase AC grid through a Voltage Source Converter (VSC), which provides active power flow from a solar PV array to the grid as well as to the load and it performs harmonics mitigation using PBT based control. The solar PV array power varies with sunlight and due to this, the solar PV grid tied VSC works only 8-10 h per day. At night, when PV power is zero, the VSC works as an active power filter for power quality improvement, and the load active power is delivered by the grid to the load connected at the point of common coupling. This increases the effective utilization of a VSC. The system is modelled and simulated using MATLAB and simulated responses of the system at nonlinear loads and varying environmental conditions are also validated experimentally on a prototype developed in the laboratory.

Controlling total spot power from holographic laser by superimposing a binary phase grating.

Science.gov (United States)

Liu, Xiang; Zhang, Jian; Gan, Yu; Wu, Liying

2011-04-25

By superimposing a tunable binary phase grating with a conventional computer-generated hologram, the total power of multiple holographic 3D spots can be easily controlled by changing the phase depth of grating with high accuracy to a random power value for real-time optical manipulation without extra power loss. Simulation and experiment results indicate that a resolution of 0.002 can be achieved at a lower time cost for normalized total spot power.

EXPERIMENTAL RESULTS OF THE NEPHELINE PHASE III STUDY

Energy Technology Data Exchange (ETDEWEB)

Fox, K.; Edwards, T.

2009-11-09

This study is the third phase in a series of experiments designed to reduce conservatism in the model that predicts the formation of nepheline, a crystalline phase that can reduce the durability of high level waste glass. A Phase I study developed a series of glass compositions that were very durable while their nepheline discriminator values were well below the current nepheline discriminator limit of 0.62, where nepheline is predicted to crystallize upon slow cooling. A Phase II study selected glass compositions to identify any linear effects of composition on nepheline crystallization and that were restricted to regions that fell within the validation ranges of the Defense Waste Processing Facility (DWPF) Product Composition Control System (PCCS) models. However, it was not possible to identify any linear effects of composition on chemical durability performance for this set of study glasses. The results of the Phase II study alone were not sufficient to recommend modification of the current nepheline discriminator. It was recommended that the next series of experiments continue to focus not only on compositional regions where the PCCS models are considered applicable (i.e., the model validation ranges), but also be restricted to compositional regions where the only constraint limiting processing is the current nepheline discriminator. Two methods were used in selecting glasses for this Phase III nepheline study. The first was based on the relationship of the current nepheline discriminator model to the other DWPF PCCS models, and the second was based on theory of crystallization in mineral and glass melts. A series of 29 test glass compositions was selected for this study using a combination of the two approaches. The glasses were fabricated and characterized in the laboratory. After reviewing the data, the study glasses generally met the target compositions with little issue. Product Consistency Test results correlated well with the crystallization analyses in

The feasibility of a batteryless PV powered vaccine fridge

Energy Technology Data Exchange (ETDEWEB)

Gwillim, J.; Polack, P.; Marks, K.

2002-07-01

An investigation into the feasibility of a batteryless PV-powered refrigerator for storing vaccines was undertaken by Dulas Ltd, Lec plc. Such a device would be valuable in places with no mains supply of electric power. Four criteria to be satisfied were listed. The work was undertaken as three phases: (i) consideration of materials and design; (ii) practical evaluation of the theoretical models; (iii) development of a test bed; and (iv) testing the system. A feature of the system was the use of phase change material rather than lead acid batteries for energy storage.

Complex motion of a vehicle through a series of signals controlled by power-law phase

Science.gov (United States)

Nagatani, Takashi

2017-07-01

We study the dynamic motion of a vehicle moving through the series of traffic signals controlled by the position-dependent phase of power law. All signals are controlled by both cycle time and position-dependent phase. The dynamic model of the vehicular motion is described in terms of the nonlinear map. The vehicular motion varies in a complex manner by varying cycle time for various values of the power of the position-dependent phase. The vehicle displays the periodic motion with a long cycle for the integer power of the phase, while the vehicular motion exhibits the very complex behavior for the non-integer power of the phase.

Phase III Advanced Anodes and Cathodes Utilized in Energy Efficient Aluminum Production Cells; FINAL

International Nuclear Information System (INIS)

Christini, R.A.; Dawless, R.K.; Ray, S.P.; Weirauch, D.A. Jr.

2001-01-01

During Phase I of the present program, Alcoa developed a commercial cell concept that has been estimated to save 30% of the energy required for aluminum smelting. Phase ii involved the construction of a pilot facility and operation of two pilots. Phase iii of the Advanced Anodes and Cathodes Program was aimed at bench experiments to permit the resolution of certain questions to be followed by three pilot cells. All of the milestones related to materials, in particular metal purity, were attained with distinct improvements over work in previous phases of the program. NiO additions to the ceramic phase and Ag additions to the Cu metal phase of the cermet improved corrosion resistance sufficiently that the bench scale pencil anodes met the purity milestones. Some excellent metal purity results have been obtained with anodes of the following composition: Further improvements in anode material composition appear to be dependent on a better understanding of oxide solubilities in molten cryolite. For that reason, work was commissioned with an outside consultant to model the MeO - cryolite systems. That work has led to a better understanding of which oxides can be used to substitute into the NiO-Fe2O3 ceramic phase to stabilize the ferrites and reduce their solubility in molten cryolite. An extensive number of vertical plate bench electrolysis cells were run to try to find conditions where high current efficiencies could be attained. TiB2-G plates were very inconsistent and led to poor wetting and drainage. Pure TiB2 did produce good current efficiencies at small overlaps (shadowing) between the anodes and cathodes. This bench work with vertical plate anodes and cathodes reinforced the importance of good cathode wetting to attain high current efficiencies. Because of those conclusions, new wetting work was commissioned and became a major component of the research during the third year of Phase III. While significant progress was made in several areas, much work needs to be

Comparison of the PLCS malfunction event analyses by using the CESEC III and MEDUSA codes

International Nuclear Information System (INIS)

Oh, Myung Taek; Park, Chan Eok; Kim, Shin Whan; Seo, Jong Tae

2004-01-01

The MEDUSA is a code developed by Korea Power Engineering Company (KOPEC) for non-LOCA and LOCA analysis, providing two-fluid, three-field representation of two-phase flow. In this paper, as an effort to verify the MEDUSA code, comparative simulation for Pressurizer Level Control System (PLCS) malfunction with loss of off-site power is performed for UCN 3 and 4 plants. The results by the MEDUSA are compared with those calculated by the CESEC-III, a licensing analysis code used for Korean Standard Nuclear Power Plant (KSNP)

Extraction behaviour of Am(III) and Eu(III) from nitric acid medium in TEHDGA-HDEHP impregnated resins

Energy Technology Data Exchange (ETDEWEB)

Saipriya, G.; Kumar, T. [Bhabha Atomic Research Centre Facilities, Kalpakkam (India). Kalpakkam Reprocessing Plant; Kumaresan, R.; Nayak, P.K.; Venkatesan, K.A.; Antony, M.P. [Indira Gandhi Center for Atomic Research, Kalpakkam (India). Fuel Chemistry Div.

2016-07-01

The extraction behaviour of Am(III) and Eu(III) from nitric acid medium was studied in the solvent impregnated resins containing extractants such as tetra-bis(2-ethylhexyl)diglycolamide (TEHDGA) or bis-(2-ethylhexyl)phosphoric acid (HDEHP) or mixture of TEHDGA+HDEHP. The rate of extraction of Am(III) and Eu(III) from 1 M nitric acid and the effect of various parameters, such as the concentration of nitric acid in aqueous phase and concentration of TEHDGA and HDEHP in resin phase, on the distribution coefficient of Am(III) and Eu(III) was studied. The distribution coefficient of Am(III) and Eu(III) in HDEHP-impregnated resin decreased and that in TEHDGA-impregnated resin increased, with increase in the concentration of nitric acid. However, in (TEHDGA+HDEHP) - impregnated resin, synergic extraction was observed at lower nitric acid concentration and antagonism at higher nitric acid concentration. The mechanism of Am(III) and Eu(III) extraction in the combined resin was investigated by slope analysis method. The extraction of various metal ions present in the fast reactor simulated high-level liquid waste was studied. The separation factor of Am(III) over Eu(III) was studied using citrate-buffered diethylenetriaminepentaacetic acid (DTPA) solution.

Wireless Power Transfer to a Microaerial Vehicle with a Microwave Active Phased Array

Directory of Open Access Journals (Sweden)

Shotaro Nako

2014-01-01

Full Text Available A wireless power transfer system using a microwave active phased array was developed. In the system, power is transferred to a circling microaerial vehicle (MAV by a microwave beam of 5.8 GHz, which is formed and directed to the MAV using an active phased array antenna. The MAV is expected to support observation of areas that humans cannot reach. The power beam is formed by the phased array with eight antenna elements. Input power is about 5.6 W. The peak power density at 1,500 mm altitude was 2.63 mW/cm2. The power is sent to a circling MAV. Therefore, the transfer beam should be polarized circularly to achieve a constant power supply independent of its yaw angle. To minimize the polarization loss, a sequentially routed antenna (SRA was applied to the transmitter antenna. Results show that the axial ratio of 0.440 dB was accomplished and that power fluctuation was kept below 1%.

Three-phase model and power-flow analysis of microgrids and virtual power plants

Energy Technology Data Exchange (ETDEWEB)

Kamh, M.Z.; Iravani, R. [Toronto Univ., ON (Canada). Dept. of Electrical and Computer Engineering, Energy Systems Group

2009-07-01

A distributed energy resources (DER) unit can be a distributed generation unit, a distributed storage unit, or a hybrid of the two. It can be dispatchable, non-dispatchable or pseudo-dispatchable. A DER unit is connected to the hosting utility directly or via an electronic converter. A three-phase model and power-flow analysis of microgrids and virtual power plants was presented. The presentation discussed DER classification; microgrids and virtual power plants; motivations and goals; and a proposed DER model and power flow approach. Validation and results were also offered. The developed algorithm was implemented in the sequence-component frame using the MATLAB platform. Case studies were offered in order to verify the accuracy of the DER model and the power-flow program. It was concluded that the developed software accommodates different DER configurations and accurately reflects their control strategies. figs.

German risk study 'nuclear power plants, phase B'

International Nuclear Information System (INIS)

Heuser, F.W.

1989-01-01

The results of the German risk study 'Nuclear power plants, phase B' indicate that an accident in a nuclear power plant which cannot be managed by the safety systems according to design, is extremely improbable: Its probability is at about 3 to 100,000 per year and plant. Even if the safety systems fail, emergency measures can be effected in a nuclear power plant to prevent an accident. These in-plant emergency measures diminish the probability of a core meltdown to about 4 to 1,000,000 per year and plant. Hence, the accident risk is greatly reduced. The information given by the author are to smooth the emotional edge in the discussion about the safety of nuclear power plants. (orig.) [de

Neutral bidentate N-heterocyclic ligands - phase transfer reagents improving the kinetics of solvent extraction of Am(III) and Eu(III) ions with tetradentate 6,6'-bis-(diethyl-1,2,4-triazin-3-yl)-2,2'-bipyridine

International Nuclear Information System (INIS)

Narbutt, J.; Krejzler, J.

2008-01-01

Poor kinetics of solvent extraction of Am(III) and Eu(III) ions from 1 M HNO 3 with 6,6'-bis-(diethyl-1,2,4-triazin-3-yl)-2,2'-bipyridine (etBTBP) has been improved by adding an auxiliary bidentate N-heterocyclic ligand to the extraction system. Two such ligands were studied, derivatives of bis-triazine and pyridine-triazine, which alone poorly extract the metal ions, but together with etBTBP they act as phase transfer reagents, improving the extraction kinetics to a different degree. The ability to transfer the metal ions from aqueous to organic phase depends on lipophilicity and acid/base properties of these auxiliary ligands, as well as on the mode of shaking the two liquid phases - gentle or vigorous. (orig.)

Phase diagram of power law and Lennard-Jones systems: Crystal phases

International Nuclear Information System (INIS)

Travesset, Alex

2014-01-01

An extensive characterization of the low temperature phase diagram of particles interacting with power law or Lennard-Jones potentials is provided from Lattice Dynamical Theory. For power law systems, only two lattice structures are stable for certain values of the exponent (or softness) (A15, body centered cube (bcc)) and two more (face centered cubic (fcc), hexagonal close packed (hcp)) are always stable. Among them, only the fcc and bcc are equilibrium states. For Lennard-Jones systems, the equilibrium states are either hcp or fcc, with a coexistence curve in pressure and temperature that shows reentrant behavior. The hcp solid never coexists with the liquid. In all cases analyzed, for both power law and Lennard-Jones potentials, the fcc crystal has higher entropy than the hcp. The role of anharmonic terms is thoroughly analyzed and a general thermodynamic integration to account for them is proposed

German risk study on nuclear power stations. Phase B

International Nuclear Information System (INIS)

1989-11-01

The German Risk Study on Nuclear Power Stations is concerned with investigations of accidents in nuclear facilities and their associated risks. These investigations are undertaken on behalf of the federal Minister of Research and Technology. They have been broken down into two phases (Phase A and Phase B). The results of Phase A were published in 1979 (GRS 79). This report contains a summary of the investigations relating to Phase B. After an introduction setting out the basic principles and aim of the study, a general review will be given of the most important results. The course of the investigations and the results have already been published in a Technical Report (GRS 89). (author)

Broadband microwave photonic fully tunable filter using a single heterogeneously integrated III-V/SOI-microdisk-based phase shifter.

Science.gov (United States)

Lloret, Juan; Morthier, Geert; Ramos, Francisco; Sales, Salvador; Van Thourhout, Dries; Spuesens, Thijs; Olivier, Nicolas; Fédéli, Jean-Marc; Capmany, José

2012-05-07

A broadband microwave photonic phase shifter based on a single III-V microdisk resonator heterogeneously integrated on and coupled to a nanophotonic silicon-on-insulator waveguide is reported. The phase shift tunability is accomplished by modifying the effective index through carrier injection. A comprehensive semi-analytical model aiming at predicting its behavior is formulated and confirmed by measurements. Quasi-linear and continuously tunable 2π phase shifts at radiofrequencies greater than 18 GHz are experimentally demonstrated. The phase shifter performance is also evaluated when used as a key element in tunable filtering schemes. Distortion-free and wideband filtering responses with a tuning range of ~100% over the free spectral range are obtained.

Extraction and separation studies of Ga(III, In(III and Tl(III using the neutral organophosphorous extractant, Cyanex-923

Directory of Open Access Journals (Sweden)

P. M. DHADKE

2003-07-01

Full Text Available The neutral extractant, Cyanes-923 has been used for the extraction and separation of gallium(III, indium(III and thallium(III from acidic solution. These metal ions were found to be quantitatively extracted with Cyanex-923 in toluene in the pH range 4.5–5.5, 5.0–6.5 and 1.5–3.0, respectively, and from the organic phase they can be stripped with 2.0 mol dm-3 HNO3, 3.0 mol dm-3 HNO3 and 3.0 mol dm-3 HCl, respectively. The effect of pH equilibration period, diluents, diverse ions and stripping agents on the extraction of Ga(III, In(III and Tl(III has been studied. The stroichiometry of the extracted species of these metal ions was determined on the basis of the slope analysis method. The reaction proceed by solvation and the probable extracted species found were [MCl3. 3Cyanex-923] [where M = Ga(III or In(III ] and [HTlCl4. 3Cyanex-923]. Based on these results a sequential procedure for the separation of Ga(III, In(III and Tl(III from each other was developed.

Formation of visual memories controlled by gamma power phase-locked to alpha oscillations

Science.gov (United States)

Park, Hyojin; Lee, Dong Soo; Kang, Eunjoo; Kang, Hyejin; Hahm, Jarang; Kim, June Sic; Chung, Chun Kee; Jiang, Haiteng; Gross, Joachim; Jensen, Ole

2016-06-01

Neuronal oscillations provide a window for understanding the brain dynamics that organize the flow of information from sensory to memory areas. While it has been suggested that gamma power reflects feedforward processing and alpha oscillations feedback control, it remains unknown how these oscillations dynamically interact. Magnetoencephalography (MEG) data was acquired from healthy subjects who were cued to either remember or not remember presented pictures. Our analysis revealed that in anticipation of a picture to be remembered, alpha power decreased while the cross-frequency coupling between gamma power and alpha phase increased. A measure of directionality between alpha phase and gamma power predicted individual ability to encode memory: stronger control of alpha phase over gamma power was associated with better memory. These findings demonstrate that encoding of visual information is reflected by a state determined by the interaction between alpha and gamma activity.

Newton Power Flow Methods for Unbalanced Three-Phase Distribution Networks

NARCIS (Netherlands)

Sereeter, B.; Vuik, C.; Witteveen, C.

2017-01-01

Two mismatch functions (power or current) and three coordinates (polar, Cartesian andcomplex form) result in six versions of the Newton–Raphson method for the solution of powerflow problems. In this paper, five new versions of the Newton power flow method developed forsingle-phase problems in our

Organic Rankine Kilowatt Isotope Power System. Final phase I report

International Nuclear Information System (INIS)

1978-01-01

On 1 August 1975 under Department of Energy Contract EN-77-C-02-4299, Sundstrand Energy Systems commenced development of a Kilowatt Isotope Power System (KIPS) directed toward satisfying the higher power requirements of satellites of the 1980s and beyond. The KIPS is a 238 PuO 2 fueled organic Rankine cycle turbine power system which will provide design output power in the range of 500 to 2000 W/sub (e)/ with a minimum of system changes. The principal objectives of the Phase 1 development effort were to: conceptually design a flight system; design a Ground Demonstration System (GDS) that is prototypic of the flight system in order to prove the feasibility of the flight system design; fabricate and assemble the GDS; and performance and endurance test the GDS using electric heaters in lieu of the isotope heat source. Results of the work performed under the Phase 1 contract to 1 July 1978 are presented

Dynamic Isotope Power System: technology verification phase, program plan, 1 October 1978

International Nuclear Information System (INIS)

1979-01-01

The technology verification phase program plan of the Dynamic Isotope Power System (DIPS) project is presented. DIPS is a project to develop a 0.5 to 2.0 kW power system for spacecraft using an isotope heat source and a closed-cycle Rankine power-system with an organic working fluid. The technology verification phase's purposes are to increase the system efficiency to over 18%, to demonstrate system reliability, and to provide an estimate for flight test scheduling. Progress toward these goals is reported

Sampling phase lock loop (PLL) with low power clock buffer

NARCIS (Netherlands)

Gao, X.; Bahai, A.; Bohsali, M.; Djabbari, A.; Klumperink, Eric A.M.; Nauta, Bram; Socci, G.

2013-01-01

A sampling phase locked loop (PLL) circuit includes a pull-up/down buffer configured to convert an oscillator reference clock into a square wave sampling control signal input to a sampling phase detector. The buffer circuit is configured to reduce power by controlling the switching of the pull-up

Phase III trial of high- vs. low-dose-rate interstitial radiotherapy for early mobile tongue cancer

International Nuclear Information System (INIS)

Inoue, Takehiro; Inoue, Toshihiko; Yoshida, Ken; Yoshioka, Yasuo; Shimamoto, Shigetoshi; Tanaka, Eiichi; Yamazaki, Hideya; Shimizutani, Kimishige; Teshima, Teruki; Furukawa, Souhei

2001-01-01

Purpose: Early mobile tongue cancer can be controlled with interstitial radiotherapy (ISRT). We carried out a Phase III trial to compare the treatment results of low-dose-rate (Ld) ISRT and high-dose-rate (HDR) ISRT for early mobile tongue cancer. Methods and Materials: From April 1992 through October 1996, 59 patients with cancer of the early mobile tongue were registered in this Phase III study. Eight patients were excluded from the evaluation because of violations of the requirements for this study. Of 51 eligible patients, 26 patients were treated with LDR-ISRT (70 Gy/4-9 days) and 25 patients with HDR-ISRT (60 Gy/10 fractions/1 week). For the hyperfractionated HDR-ISRT, the time interval between 2 fractions was more than 6 h. Results: Five-year local control rates of the LDR and HDR groups were 84% and 87% respectively. Nodal metastasis occurred in 6 patients in each group. Five-year nodal control rates of the LDR and HDR groups were 77% and 76%, respectively. Conclusion: Hyperfractionated HDR-ISRT for early mobile tongue cancer has the same local control compared with continuous LDR-ISRT. Hyperfractionated HDR-ISRT is an alternative treatment for continuous LDR-ISRT

High-power three-port three-phase bidirectional DC-DC converter

NARCIS (Netherlands)

Tao, H.; Duarte, J.L.; Hendrix, M.A.M.

2007-01-01

This paper proposes a three-port three-phase bidirectional dc-dc converter suitable for high-power applications. The converter combines a slow primary source and a fast storage to power a common load (e.g., an inverter). Since this type of system is gaining popularity in sustainable energy

Predicting hypothetical willingness to participate (WTP) in a future phase III HIV vaccine trial among high-risk adolescents.

Science.gov (United States)

Giocos, Georgina; Kagee, Ashraf; Swartz, Leslie

2008-11-01

The present study sought to determine whether the Theory of Planned Behaviour predicted stated hypothetical willingness to participate (WTP) in future Phase III HIV vaccine trials among South African adolescents. Hierarchical logistic regression analyses showed that The Theory of Planned Behaviour (TPB) significantly predicted WTP. Of all the predictors, Subjective norms significantly predicted WTP (OR = 1.19, 95% C.I. = 1.06-1.34). A stepwise logistic regression analysis revealed that Subjective Norms (OR = 1.19, 95% C.I. = 1.07-1.34) and Attitude towards participation in an HIV vaccine trial (OR = 1.32, 95% C.I. = 1.00-1.74) were significant predictors of WTP. The addition of Knowledge of HIV vaccines and HIV vaccine trials, Perceived self-risk of HIV infection, Health-promoting behaviours and Attitudes towards HIV/AIDS yielded non-significant results. These findings provide support for the Theory of Reasoned Action (TRA) and suggest that psychosocial factors may play an important role in WTP in Phase III HIV vaccine trials among adolescents.

A NOVEL THREE PHASE UNITY POWER FACTOR CONVERTER

Directory of Open Access Journals (Sweden)

Bekir Sami SAZAK

1998-03-01

Full Text Available The proposed unity power factor converter system which is able to operate from a 150V three-phase supply whilst delivering the required 200V DC voltage has been built and tested. This circuit functions as a high power factor low harmonic rectifier based on the concept that the peak capacitor voltages are proportional to the line input currents. Hence the low frequency components of the capacitor voltages are also approximately proportional to the line input currents. The system can be designed to achieve nearly sinusoidal supply input currents, when operated with discontinuous resonant capacitor voltages Output power control is achieved by variations of the IGBTs switching frequency. The converter is therefore able to compensate for any changes in the load resistance. The proposed topology offers advantages, including: a relatively simple power, control and protection circuits, high power capability, and high converter efficiencies.

Fuel cell power systems for remote applications. Phase 1 final report and business plan

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-02-01

The goal of the Fuel Cell Power Systems for Remote Applications project is to commercialize a 0.1--5 kW integrated fuel cell power system (FCPS). The project targets high value niche markets, including natural gas and oil pipelines, off-grid homes, yachts, telecommunication stations and recreational vehicles. Phase 1 includes the market research, technical and financial analysis of the fuel cell power system, technical and financial requirements to establish manufacturing capability, the business plan, and teaming arrangements. Phase 1 also includes project planning, scope of work, and budgets for Phases 2--4. The project is a cooperative effort of Teledyne Brown Engineering--Energy Systems, Schatz Energy Research Center, Hydrogen Burner Technology, and the City of Palm Desert. Phases 2 through 4 are designed to utilize the results of Phase 1, to further the commercial potential of the fuel cell power system. Phase 2 focuses on research and development of the reformer and fuel cell and is divided into three related, but potentially separate tasks. Budgets and timelines for Phase 2 can be found in section 4 of this report. Phase 2 includes: Task A--Develop a reformate tolerant fuel cell stack and 5 kW reformer; Task B--Assemble and deliver a fuel cell that operates on pure hydrogen to the University of Alaska or another site in Alaska; Task C--Provide support and training to the University of Alaska in the setting up and operating a fuel cell test lab. The Phase 1 research examined the market for power systems for off-grid homes, yachts, telecommunication stations and recreational vehicles. Also included in this report are summaries of the previously conducted market reports that examined power needs for remote locations along natural gas and oil pipelines. A list of highlights from the research can be found in the executive summary of the business plan.

Technology verification phase. Dynamic isotope power system. Final report

Energy Technology Data Exchange (ETDEWEB)

Halsey, D.G.

1982-03-10

The Phase I requirements of the Kilowatt Isotope Power System (KIPS) program were to make a detailed Flight System Conceptual Design (FSCD) for an isotope fueled organic Rankine cycle power system and to build and test a Ground Demonstration System (GDS) which simulated as closely as possible the operational characteristics of the FSCD. The activities and results of Phase II, the Technology Verification Phase, of the program are reported. The objectives of this phase were to increase system efficiency to 18.1% by component development, to demonstrate system reliability by a 5000 h endurance test and to update the flight system design. During Phase II, system performance was improved from 15.1% to 16.6%, an endurance test of 2000 h was performed while the flight design analysis was limited to a study of the General Purpose Heat Source, a study of the regenerator manufacturing technique and analysis of the hardness of the system to a laser threat. It was concluded from these tests that the GDS is basically prototypic of a flight design; all components necessary for satisfactory operation were demonstrated successfully at the system level; over 11,000 total h of operation without any component failure attested to the inherent reliability of this type of system; and some further development is required, specifically in the area of performance. (LCL)

Technology verification phase. Dynamic isotope power system. Final report

International Nuclear Information System (INIS)

Halsey, D.G.

1982-01-01

The Phase I requirements of the Kilowatt Isotope Power System (KIPS) program were to make a detailed Flight System Conceptual Design (FSCD) for an isotope fueled organic Rankine cycle power system and to build and test a Ground Demonstration System (GDS) which simulated as closely as possible the operational characteristics of the FSCD. The activities and results of Phase II, the Technology Verification Phase, of the program are reported. The objectives of this phase were to increase system efficiency to 18.1% by component development, to demonstrate system reliability by a 5000 h endurance test and to update the flight system design. During Phase II, system performance was improved from 15.1% to 16.6%, an endurance test of 2000 h was performed while the flight design analysis was limited to a study of the General Purpose Heat Source, a study of the regenerator manufacturing technique and analysis of the hardness of the system to a laser threat. It was concluded from these tests that the GDS is basically prototypic of a flight design; all components necessary for satisfactory operation were demonstrated successfully at the system level; over 11,000 total h of operation without any component failure attested to the inherent reliability of this type of system; and some further development is required, specifically in the area of performance

Code of Conduct for wind-power projects - Phase 3

International Nuclear Information System (INIS)

Strub, P.; Ziegler, Ch.

2008-11-01

This paper discusses the results of phase three of a project concerning wind-power projects. Feasibility and strategy aspects are examined and discussed. The current state of the wind power market is discussed on the basis of the results of a survey made on the subject. The social acceptance of wind power installations is discussed, whereby the rejection of particular projects is compared with a general lack of acceptance. Requirements placed on such projects and possible solutions are discussed. Finally, the feasibility of setting up a code of conduct in the area of wind-power projects is discussed and the definition of further instruments is examined

The effect of phase difference between powered electrodes on RF plasmas

International Nuclear Information System (INIS)

Proschek, M; Yin, Y; Charles, C; Aanesland, A; McKenzie, D R; Bilek, M M; Boswell, R W

2005-01-01

This paper presents the results of measurements carried out on plasmas created in five different RF discharge systems. These systems all have two separately powered RF (13.56 MHz) electrodes, but differ in overall size and in the geometry of both vacuum chambers and RF electrodes or antennae. The two power supplies were synchronized with a phase-shift controller. We investigated the influence of the phase difference between the two RF electrodes on plasma parameters and compared the different system geometries. Single Langmuir probes were used to measure the plasma parameters in a region between the electrodes. Floating potential and ion density were affected by the phase difference and we found a strong influence of the system geometry on the observed phase difference dependence. Both ion density and floating potential curves show asymmetries around maxima and minima. These asymmetries can be explained by a phase dependence of the time evolution of the electrode-wall coupling within an RF-cycle resulting from the asymmetric system geometry

A single-phase axially-magnetized permanent-magnet oscillating machine for miniature aerospace power sources

Directory of Open Access Journals (Sweden)

Yi Sui

2017-05-01

Full Text Available A single-phase axially-magnetized permanent-magnet (PM oscillating machine which can be integrated with a free-piston Stirling engine to generate electric power, is investigated for miniature aerospace power sources. Machine structure, operating principle and detent force characteristic are elaborately studied. With the sinusoidal speed characteristic of the mover considered, the proposed machine is designed by 2D finite-element analysis (FEA, and some main structural parameters such as air gap diameter, dimensions of PMs, pole pitches of both stator and mover, and the pole-pitch combinations, etc., are optimized to improve both the power density and force capability. Compared with the three-phase PM linear machines, the proposed single-phase machine features less PM use, simple control and low controller cost. The power density of the proposed machine is higher than that of the three-phase radially-magnetized PM linear machine, but lower than the three-phase axially-magnetized PM linear machine.

A single-phase axially-magnetized permanent-magnet oscillating machine for miniature aerospace power sources

Science.gov (United States)

Sui, Yi; Zheng, Ping; Cheng, Luming; Wang, Weinan; Liu, Jiaqi

2017-05-01

A single-phase axially-magnetized permanent-magnet (PM) oscillating machine which can be integrated with a free-piston Stirling engine to generate electric power, is investigated for miniature aerospace power sources. Machine structure, operating principle and detent force characteristic are elaborately studied. With the sinusoidal speed characteristic of the mover considered, the proposed machine is designed by 2D finite-element analysis (FEA), and some main structural parameters such as air gap diameter, dimensions of PMs, pole pitches of both stator and mover, and the pole-pitch combinations, etc., are optimized to improve both the power density and force capability. Compared with the three-phase PM linear machines, the proposed single-phase machine features less PM use, simple control and low controller cost. The power density of the proposed machine is higher than that of the three-phase radially-magnetized PM linear machine, but lower than the three-phase axially-magnetized PM linear machine.

Social class, political power, and the state: their implications in medicine--part III.

Science.gov (United States)

Navarro, V

1977-01-01

This is the third part of an article on the distribution of power and the nature of the state in Western industrialized societies and their implications in medicine. Parts I and II were published in the preceding issue of this Journal. Part I presented a critique of contemporary theories of the Western system of power; discussed the countervailing pluralist and power of elite theories, as well as those of bureaucratic and professional control; and concluded with an examination of the Marxist theories of economic determinism, structural determinism, and corporate statism. Part II presented a Marxist theory of the role, nature, and characteristics of state intervention. Part III focuses on the mode of that intervention and the reasons for its growth, with an added analysis of the attributes of state intervention in the health sector, and of the dialectical relationship between its growth and the current fiscal crisis of the state. In all three parts, the focus is on Western European countries and on North America, with many examples and categories from the area of medicine.

Expression profiling of blood samples from an SU5416 Phase III metastatic colorectal cancer clinical trial: a novel strategy for biomarker identification

International Nuclear Information System (INIS)

DePrimo, Samuel E; Wong, Lily M; Khatry, Deepak B; Nicholas, Susan L; Manning, William C; Smolich, Beverly D; O'Farrell, Anne-Marie; Cherrington, Julie M

2003-01-01

Microarray-based gene expression profiling is a powerful approach for the identification of molecular biomarkers of disease, particularly in human cancers. Utility of this approach to measure responses to therapy is less well established, in part due to challenges in obtaining serial biopsies. Identification of suitable surrogate tissues will help minimize limitations imposed by those challenges. This study describes an approach used to identify gene expression changes that might serve as surrogate biomarkers of drug activity. Expression profiling using microarrays was applied to peripheral blood mononuclear cell (PBMC) samples obtained from patients with advanced colorectal cancer participating in a Phase III clinical trial. The PBMC samples were harvested pre-treatment and at the end of the first 6-week cycle from patients receiving standard of care chemotherapy or standard of care plus SU5416, a vascular endothelial growth factor (VEGF) receptor tyrosine kinase (RTK) inhibitor. Results from matched pairs of PBMC samples from 23 patients were queried for expression changes that consistently correlated with SU5416 administration. Thirteen transcripts met this selection criterion; six were further tested by quantitative RT-PCR analysis of 62 additional samples from this trial and a second SU5416 Phase III trial of similar design. This method confirmed four of these transcripts (CD24, lactoferrin, lipocalin 2, and MMP-9) as potential biomarkers of drug treatment. Discriminant analysis showed that expression profiles of these 4 transcripts could be used to classify patients by treatment arm in a predictive fashion. These results establish a foundation for the further exploration of peripheral blood cells as a surrogate system for biomarker analyses in clinical oncology studies

Expression profiling of blood samples from an SU5416 Phase III metastatic colorectal cancer clinical trial: a novel strategy for biomarker identification

Directory of Open Access Journals (Sweden)

Smolich Beverly D

2003-02-01

Full Text Available Abstract Background Microarray-based gene expression profiling is a powerful approach for the identification of molecular biomarkers of disease, particularly in human cancers. Utility of this approach to measure responses to therapy is less well established, in part due to challenges in obtaining serial biopsies. Identification of suitable surrogate tissues will help minimize limitations imposed by those challenges. This study describes an approach used to identify gene expression changes that might serve as surrogate biomarkers of drug activity. Methods Expression profiling using microarrays was applied to peripheral blood mononuclear cell (PBMC samples obtained from patients with advanced colorectal cancer participating in a Phase III clinical trial. The PBMC samples were harvested pre-treatment and at the end of the first 6-week cycle from patients receiving standard of care chemotherapy or standard of care plus SU5416, a vascular endothelial growth factor (VEGF receptor tyrosine kinase (RTK inhibitor. Results from matched pairs of PBMC samples from 23 patients were queried for expression changes that consistently correlated with SU5416 administration. Results Thirteen transcripts met this selection criterion; six were further tested by quantitative RT-PCR analysis of 62 additional samples from this trial and a second SU5416 Phase III trial of similar design. This method confirmed four of these transcripts (CD24, lactoferrin, lipocalin 2, and MMP-9 as potential biomarkers of drug treatment. Discriminant analysis showed that expression profiles of these 4 transcripts could be used to classify patients by treatment arm in a predictive fashion. Conclusions These results establish a foundation for the further exploration of peripheral blood cells as a surrogate system for biomarker analyses in clinical oncology studies.

The Three-Phase Power Router and Its Operation with Matrix Converter toward Smart-Grid Applications

Directory of Open Access Journals (Sweden)

Alexandros Kordonis

2015-04-01

Full Text Available A power router has been recently developed for both AC and DC applications that has the potential for smart-grid applications. This study focuses on three-phase power switching through the development of an experimental setup which consists of a three-phase direct AC/AC matrix converter with a power router attached to its output. Various experimental switching scenarios with the loads connected to different input sources were investigated. The crescent introduction of decentralized power generators throughout the power-grid obligates us to take measurements for a better distribution and management of the power. Power routers and matrix converters have great potential to succeed this goal with the help of power electronics devices. In this paper, a novel experimental three-phase power switching was achieved and the advantages of this operation are presented, such as on-demand and constant power supply at the desired loads.

Assessing the impact of safety monitoring on the efficacy analysis in large Phase III group sequential trials with non-trivial safety event rate.

Science.gov (United States)

Weng, Yanqiu; Palesch, Yuko Y; DeSantis, Stacia M; Zhao, Wenle

2016-01-01

In Phase III clinical trials for life-threatening conditions, some serious but expected adverse events, such as early deaths or congestive heart failure, are often treated as the secondary or co-primary endpoint, and are closely monitored by the Data and Safety Monitoring Committee (DSMC). A naïve group sequential design (GSD) for such a study is to specify univariate statistical boundaries for the efficacy and safety endpoints separately, and then implement the two boundaries during the study, even though the two endpoints are typically correlated. One problem with this naïve design, which has been noted in the statistical literature, is the potential loss of power. In this article, we develop an analytical tool to evaluate this negative impact for trials with non-trivial safety event rates, particularly when the safety monitoring is informal. Using a bivariate binary power function for the GSD with a random-effect component to account for subjective decision-making in safety monitoring, we demonstrate how, under common conditions, the power loss in the naïve design can be substantial. This tool may be helpful to entities such as the DSMCs when they wish to deviate from the prespecified stopping boundaries based on safety measures.

Design requirements document for the phase 1 privatization electrical power system

Energy Technology Data Exchange (ETDEWEB)

Singh, G.

1997-10-31

The electrical system for the Phase 1 privatization facilities will support the TWRS mission by providing the electrical power to the Phase 1 privatized facilities. This system will receive power from the Department of Energy-Richland Operations (RL) A4-8 230 kV transmission system powered from Bonneville Power Administration (BPA) Ashe and Midway 230 kV Substations. The existing RL 230 kV transmission line will be modified and looped 1021 into the new 230 kV substation bus. The new substation will be located in the vicinity of the privatized facilities, approximately 3.2 km (2 mi) south of the existing RL A4-8 230 kV transmission line. The substation will be capable of providing up to 40 MW of electrical power to support the Phase 1 privatization facilities and has space for accommodating future expansions. The substation will require at least two 230-13.8 kV transformers, 13.8 kV split bus switchgear, switchgear building, grounding transformers, instrument transformers, control and monitoring equipment, associated protection and isolation devices, lightning protection, yard lighting, cable and raceways, and infrastructure needed to provide desired availability and reliability. The power from the 13.8 kV switchgear located in the switchgear building will be delivered at the privatization facilities site boundaries. The 13.8 kV distribution system inside the privatization facilities site boundaries is the responsibility of the privatization contract.

Design requirements document for the phase 1 privatization electrical power system

International Nuclear Information System (INIS)

Singh, G.

1997-01-01

The electrical system for the Phase 1 privatization facilities will support the TWRS mission by providing the electrical power to the Phase 1 privatized facilities. This system will receive power from the Department of Energy-Richland Operations (RL) A4-8 230 kV transmission system powered from Bonneville Power Administration (BPA) Ashe and Midway 230 kV Substations. The existing RL 230 kV transmission line will be modified and looped 1021 into the new 230 kV substation bus. The new substation will be located in the vicinity of the privatized facilities, approximately 3.2 km (2 mi) south of the existing RL A4-8 230 kV transmission line. The substation will be capable of providing up to 40 MW of electrical power to support the Phase 1 privatization facilities and has space for accommodating future expansions. The substation will require at least two 230-13.8 kV transformers, 13.8 kV split bus switchgear, switchgear building, grounding transformers, instrument transformers, control and monitoring equipment, associated protection and isolation devices, lightning protection, yard lighting, cable and raceways, and infrastructure needed to provide desired availability and reliability. The power from the 13.8 kV switchgear located in the switchgear building will be delivered at the privatization facilities site boundaries. The 13.8 kV distribution system inside the privatization facilities site boundaries is the responsibility of the privatization contract

Maintenance risk management in Dayabay nuclear power plant

International Nuclear Information System (INIS)

He Xuhong; Tong Jiejuan

2005-01-01

The importance of proper maintenance to safe and reliable nuclear plant operation has long been recognized by the nuclear utility and regulatory body. This paper presents a process of maintenance risk management developed for a Chinese Nuclear Power Plant (NPP). The process includes three phases: (I) long term maintenance plan risk management, (II) monthly maintenance plan risk management, and (III) detailed risk management for high risk configuration. A risk matrix is developed for phase I whose purpose is to provide a rough guide for risk management in the making of the annual maintenance plan. For Phase II and Phase III, a software tool named Maintenance- Risk-Monitor is developed based on the internal initiating event, level 1 PSA model. The results of Phase II are the risk information of the all plant configurations caused by the unavailability of the components included the monthly maintenance plan. When the increase of core damage frequency (CDF) or the incremental core damage probability (ICDP) of a configuration is higher than the corresponding thresholds, Phase III is needed for this high risk configuration to get the useful information such as risk-importance components, human actions and initial events, from which appropriate preventive measurements could be derived. It is hoped that the provided process of maintenance risk management, together with the developed software tool, could facilitate the maintenance activities in the NPPs of China. (authors)

Design and Tuning of a Modified Power-Based PLL for Single-Phase Grid-Connected Power Conditioning Systems

DEFF Research Database (Denmark)

Golestan, Saeed; Monfared, Mohammad; D. Freijedo, Francisco

2012-01-01

One of the most important aspects for the proper operation of the single-phase grid-tied power-conditioning systems is the synchronization with the utility grid. Among various synchronization techniques, phase locked loop (PLL) based algorithms have found a lot of interest for the advantages...

Hysteresis, phase transitions, and dangerous transients in electrical power distribution systems.

Science.gov (United States)

Duclut, Charlie; Backhaus, Scott; Chertkov, Michael

2013-06-01

The majority of dynamical studies in power systems focus on the high-voltage transmission grids where models consider large generators interacting with crude aggregations of individual small loads. However, new phenomena have been observed indicating that the spatial distribution of collective, nonlinear contribution of these small loads in the low-voltage distribution grid is crucial to the outcome of these dynamical transients. To elucidate the phenomenon, we study the dynamics of voltage and power flows in a spatially extended distribution feeder (circuit) connecting many asynchronous induction motors and discover that this relatively simple 1+1 (space+time) dimensional system exhibits a plethora of nontrivial spatiotemporal effects, some of which may be dangerous for power system stability. Long-range motor-motor interactions mediated by circuit voltage and electrical power flows result in coexistence and segregation of spatially extended phases defined by individual motor states, a "normal" state where the motors' mechanical (rotation) frequency is slightly smaller than the nominal frequency of the basic ac flows and a "stalled" state where the mechanical frequency is small. Transitions between the two states can be initiated by a perturbation of the voltage or base frequency at the head of the distribution feeder. Such behavior is typical of first-order phase transitions in physics, and this 1+1 dimensional model shows many other properties of a first-order phase transition with the spatial distribution of the motors' mechanical frequency playing the role of the order parameter. In particular, we observe (a) propagation of the phase-transition front with the constant speed (in very long feeders) and (b) hysteresis in transitions between the normal and stalled (or partially stalled) phases.

Japanese contributions to IAEA INTOR workshop, phase two A, part 2, chapter III: impurity control (engineering)

International Nuclear Information System (INIS)

Seki, Masahiro; Miki, Nobuharu; Shibutani, Yoji; Fujimura, Kaoru; Adachi, Jun-ichi; Sato, Kosuke; Fujii, Masaharu; Yamazaki, Seiichiro; Itoh, Shin-ichi.

1985-07-01

This report corresponds to the second half of Chapter III of Japanese contribution report to IAEA INTOR Workshop, Phase Two A, Part 2. Data base assessment are made on candidate materials for the divertor, limiter, and the first wall. Engineering trade-off studies are made for the high-recycling and low temperature conditions. The studies include material considerations, configuration, thermohydraulic and stress analysis, disruption, lifetime analysis, and tritium permeation. (author)

Biomass power for rural development. Technical progress report, Phase 2, July 1--September 30, 1998

Energy Technology Data Exchange (ETDEWEB)

Neuhauser, E.

1999-01-01

The project undertaken by the Salix Consortium is a multi-phased, multi-partner endeavor. Phase 1 focused on initial development and testing of the technology and forging the necessary agreements to demonstrate commercial willow production. The Phase 1 objectives have been successfully completed: preparing final design plans for two utility pulverized coal boiler for 20 MW of biopower capacity; developing fuel supply plans for the project with a goal of establishing 365 ha (900 ac) of willow; obtaining power production commitments from the power companies for Phase 2; obtaining construction and environmental permits; and developing an experimental strategy for crop production and power generation improvements needed to assure commercial success. The R and D effort also addresses environmental issues pertaining to introduction of the willow energy system. Beyond those Phase 1 requirements, the Consortium has already successfully demonstrated cofiring at Greenidge Station and has initiated development of the required nursery capacity for acreage scale-up. In Phase 2 every aspect of willow production and power generation from willow biomass will be demonstrated. The ultimate objective of Phase 2 is to transition the work performed under the Biomass Power for Rural Development project into a thriving, self-supported energy crop enterprise.

Phased antenna arrays for fast wave power generation

International Nuclear Information System (INIS)

Bosia, G.; Jacquinot, J.

1991-01-01

A method for the generation of travelling waves in the Ion Cyclotron frequency range in JET is presented. The success of the method relies on the control of the array toroidal current, which in turn, is obtained by a coordinated vectorial control of the array power sources and tuning networks. This method has general application to present and future ICRF arrays. For uninterrupted, periodically fed and resonant toroidal arrays, phased operation requires only conventional tuning devices. For localised arrays, phased operation is inefficient at low plasma coupling. This inefficiency can be however removed with the addition of external coupling structures either at the antenna or at the generator ends. The performances of JET A1 antennae in phased operation is presented. The design philosophy for the JET A2 phased arrays is also discussed. These methods are applicable and extensible to Next Step Devices design

Safety Culture in Pre-operational Phases of Nuclear Power Plant Projects

Energy Technology Data Exchange (ETDEWEB)

NONE

2012-09-15

An abundance of information exists on safety culture related to the operational phases of nuclear power plants; however, pre-operational phases present unique challenges. This publication focuses on safety culture during pre-operational phases that span the interval from before a decision to launch a nuclear power programme to first fuel load. It provides safety culture insights and focuses on eight generic issues: safety culture understanding; multicultural aspects; leadership; competencies and resource competition; management systems; learning and feedback; cultural assessments; and communication. Each issue is discussed in terms of: specific challenges; desired state; approaches and methods; and examples and resources. This publication will be of interest to newcomers and experienced individuals faced with the opportunities and challenges inherent in safety culture programmes aimed at pre-operational activities.

Safety Culture in Pre-operational Phases of Nuclear Power Plant Projects

International Nuclear Information System (INIS)

2012-01-01

An abundance of information exists on safety culture related to the operational phases of nuclear power plants; however, pre-operational phases present unique challenges. This publication focuses on safety culture during pre-operational phases that span the interval from before a decision to launch a nuclear power programme to first fuel load. It provides safety culture insights and focuses on eight generic issues: safety culture understanding; multicultural aspects; leadership; competencies and resource competition; management systems; learning and feedback; cultural assessments; and communication. Each issue is discussed in terms of: specific challenges; desired state; approaches and methods; and examples and resources. This publication will be of interest to newcomers and experienced individuals faced with the opportunities and challenges inherent in safety culture programmes aimed at pre-operational activities.

Methods of Phase and Power Control in Magnetron Transmitters for Superconducting Accelerators

Energy Technology Data Exchange (ETDEWEB)

Kazadevich, G. [MUONS Inc., Batavia; Johnson, R. [MUONS Inc., Batavia; Neubauer, M. [MUONS Inc., Batavia; Lebedev, V. [Fermilab; Schappert, W. [Fermilab; Yakovlev, V. [Fermilab

2017-05-01

Various methods of phase and power control in magnetron RF sources of superconducting accelerators intended for ADS-class projects were recently developed and studied with conventional 2.45 GHz, 1 kW, CW magnetrons operating in pulsed and CW regimes. Magnetron transmitters excited by a resonant (injection-locking) phasemodulated signal can provide phase and power control with the rates required for precise stabilization of phase and amplitude of the accelerating field in Superconducting RF (SRF) cavities of the intensity-frontier accelerators. An innovative technique that can significantly increase the magnetron transmitter efficiency at the widerange power control required for superconducting accelerators was developed and verified with the 2.45 GHz magnetrons operating in CW and pulsed regimes. High efficiency magnetron transmitters of this type can significantly reduce the capital and operation costs of the ADSclass accelerator projects.

NASA Research Announcement Phase 1 Report and Phase 2 Proposal for the Development of a Power Assisted Space Suit Glove Assembly

Science.gov (United States)

Cadogan, Dave; Lingo, Bob

1996-01-01

In July of 1996, ILC Dover was awarded Phase 1 of a contract for NASA to develop a prototype Power Assisted Space Suit glove to enhance the performance of astronauts during Extra-Vehicular Activity (EVA). This report summarizes the work performed to date on Phase 1, and details the work to be conducted on Phase 2 of the program. Phase 1 of the program consisted of research and review of related technical sources, concept brainstorming, baseline design development, modeling and analysis, component mock-up testing, and test data analysis. ILC worked in conjunction with the University of Maryland's Space Systems Laboratory (SSL) to develop the power assisted glove. Phase 2 activities will focus on the design maturation and the manufacture of a working prototype system. The prototype will be tested and evaluated in conjunction with existing space suit glove technology to determine the performance enhancement anticipated with the implementation of the power assisted joint technology in space suit gloves.

Three-phase Power Flow Calculation of Low Voltage Distribution Network Considering Characteristics of Residents Load

Science.gov (United States)

Wang, Yaping; Lin, Shunjiang; Yang, Zhibin

2017-05-01

In the traditional three-phase power flow calculation of the low voltage distribution network, the load model is described as constant power. Since this model cannot reflect the characteristics of actual loads, the result of the traditional calculation is always different from the actual situation. In this paper, the load model in which dynamic load represented by air conditioners parallel with static load represented by lighting loads is used to describe characteristics of residents load, and the three-phase power flow calculation model is proposed. The power flow calculation model includes the power balance equations of three-phase (A,B,C), the current balance equations of phase 0, and the torque balancing equations of induction motors in air conditioners. And then an alternating iterative algorithm of induction motor torque balance equations with each node balance equations is proposed to solve the three-phase power flow model. This method is applied to an actual low voltage distribution network of residents load, and by the calculation of three different operating states of air conditioners, the result demonstrates the effectiveness of the proposed model and the algorithm.

SCOPE1: a randomised phase II/III multicentre clinical trial of definitive chemoradiation, with or without cetuximab, in carcinoma of the oesophagus

International Nuclear Information System (INIS)

Hurt, Christopher N; Nixon, Lisette S; Griffiths, Gareth O; Al-Mokhtar, Ruby; Gollins, Simon; Staffurth, John N; Phillips, Ceri J; Blazeby, Jane M; Crosby, Tom D

2011-01-01

Chemoradiotherapy is the standard of care for patients with oesophageal cancer unsuitable for surgery due to the presence of co-morbidity or extent of disease, and is a standard treatment option for patients with squamous cell carcinoma of the oesophagus. Modern regimens of chemoradiotherapy can lead to significant long-term survival. However the majority of patients will die of their disease, most commonly with local progression/recurrence of their tumours. Cetuximab may overcome one of the principal mechanisms of tumour radio-resistance, namely tumour repopulation, in patients treated with chemoradiotherapy. The purpose of this research is first to determine whether the addition of cetuximab to definitive chemoradiotherapy for treatment of patients with non-metastatic carcinoma of the oesophagus is active (in terms of failure-free rate), safe, and feasible within the context of a multi-centre randomised controlled trial in the UK. If the first stage is successful then the trial will continue to accrue sufficient patients to establish whether the addition of cetuximab to the standard treatment improves overall survival. SCOPE1 is a two arm, open, randomised multicentre Phase II/III trial. Eligible patients will have histologically confirmed carcinoma of the oesophagus and have been chosen to receive definitive chemoradiotherapy by an accredited multidisciplinary team including a specialist Upper GI surgeon. 420 patients will be randomised to receive definitive chemoradiotherapy with or without cetuximab using a 1:1 allocation ratio. During Phase II of the study, the trial will assess safety (toxicity), activity (failure-free rate) and feasibility (recruitment rate and protocol dose modifications/delays) in 90 patients in the experimental arm. If the experimental arm is found to be active, safe, and feasible by the Independent Data Monitoring Committee then recruitment will continue into Phase III. This second stage will recruit a further 120 patients into each arm

SCOPE1: a randomised phase II/III multicentre clinical trial of definitive chemoradiation, with or without cetuximab, in carcinoma of the oesophagus

Directory of Open Access Journals (Sweden)

Staffurth John N

2011-10-01

Full Text Available Abstract Background Chemoradiotherapy is the standard of care for patients with oesophageal cancer unsuitable for surgery due to the presence of co-morbidity or extent of disease, and is a standard treatment option for patients with squamous cell carcinoma of the oesophagus. Modern regimens of chemoradiotherapy can lead to significant long-term survival. However the majority of patients will die of their disease, most commonly with local progression/recurrence of their tumours. Cetuximab may overcome one of the principal mechanisms of tumour radio-resistance, namely tumour repopulation, in patients treated with chemoradiotherapy. The purpose of this research is first to determine whether the addition of cetuximab to definitive chemoradiotherapy for treatment of patients with non-metastatic carcinoma of the oesophagus is active (in terms of failure-free rate, safe, and feasible within the context of a multi-centre randomised controlled trial in the UK. If the first stage is successful then the trial will continue to accrue sufficient patients to establish whether the addition of cetuximab to the standard treatment improves overall survival. Methods/Design SCOPE1 is a two arm, open, randomised multicentre Phase II/III trial. Eligible patients will have histologically confirmed carcinoma of the oesophagus and have been chosen to receive definitive chemoradiotherapy by an accredited multidisciplinary team including a specialist Upper GI surgeon. 420 patients will be randomised to receive definitive chemoradiotherapy with or without cetuximab using a 1:1 allocation ratio. During Phase II of the study, the trial will assess safety (toxicity, activity (failure-free rate and feasibility (recruitment rate and protocol dose modifications/delays in 90 patients in the experimental arm. If the experimental arm is found to be active, safe, and feasible by the Independent Data Monitoring Committee then recruitment will continue into Phase III. This second

SAFOD Phase III Core Sampling and Data Management at the Gulf Coast Repository

Directory of Open Access Journals (Sweden)

David Lockner

2011-03-01

Full Text Available The San Andreas Fault Observatory at Depth (SAFODproject is yielding new insight into the San Andreas Fault (Zoback et al., 2010; Zoback et al., this issue. SAFOD drilling started in 2002 with a pilot hole, and proceeded with three phrases of drilling and coring during the summers of 2004, 2005, and 2007 (Fig. 1. One key component of theproject is curation, sampling, and documentation of SAFOD core usage at the Integrated Ocean Drilling Program’s (IODP Gulf Coast Repository (GCR at Texas A&M University. We present here the milestones accomplished over the past two years of sampling Phase III core at the GCR.

Cyprus natural analogue project (CNAP). Phase III final report

International Nuclear Information System (INIS)

Alexander, W.R.; Milodowski, A.E.; Pitty, A.F.

2012-01-01

The CNAP Phase III project was carried out following identification of the requirement to support ongoing laboratory and modelling efforts on the potential reaction of the bentonite buffer with cementitious leachates in the repository EBS. Although it is known that the higher pH (12.5 to 13) leachates from OPC cement will degrade bentonite, it is unclear if this will also be the case for the lower pH (10 to 11) leachates typical of low alkali cements. Ongoing laboratory and URL programmes which are currently investigating this face the obstacle of slow kinetics and the production of short-lived metastable phases, meaning obtaining unambiguous results may take decades. This is exacerbated by the limitations of the thermodynamic databases for minerals of interest to models of bentonite/low alkali cement leachate reaction. It was therefore decided to implement a focussed NA study on bentonite/low alkali cement leachate reaction to provide indications of likely long-term reaction products and reaction pathways to provide feedback on the existing short-term investigations noted above and to ascertain if any critical path R and D needs to be instigated now. The results of the analyses presented here suggest that there has been very limited alkaline groundwater reaction with the bentonite. This is generally supported by both the geomorphological evidence and the natural decay series data which imply groundwater groundwater/rock interaction in the last 10 5 a. When integrated with the novel data currently being produced in the BIGRAD project, the CNAP data tend to indicate that any long-term bentonite reaction in low alkali cement leachates is minimal. (orig.)

Cyprus natural analogue project (CNAP). Phase III final report

Energy Technology Data Exchange (ETDEWEB)

Alexander, W R [Bedrock Geosciences, Auenstein (Switzerland); Milodowski, A E [British Geological Survey, Keyworth (United Kingdom); Pitty, A F [Pitty (EIA) Consulting, Norwich (United Kingdom)

2012-01-15

The CNAP Phase III project was carried out following identification of the requirement to support ongoing laboratory and modelling efforts on the potential reaction of the bentonite buffer with cementitious leachates in the repository EBS. Although it is known that the higher pH (12.5 to 13) leachates from OPC cement will degrade bentonite, it is unclear if this will also be the case for the lower pH (10 to 11) leachates typical of low alkali cements. Ongoing laboratory and URL programmes which are currently investigating this face the obstacle of slow kinetics and the production of short-lived metastable phases, meaning obtaining unambiguous results may take decades. This is exacerbated by the limitations of the thermodynamic databases for minerals of interest to models of bentonite/low alkali cement leachate reaction. It was therefore decided to implement a focussed NA study on bentonite/low alkali cement leachate reaction to provide indications of likely long-term reaction products and reaction pathways to provide feedback on the existing short-term investigations noted above and to ascertain if any critical path R and D needs to be instigated now. The results of the analyses presented here suggest that there has been very limited alkaline groundwater reaction with the bentonite. This is generally supported by both the geomorphological evidence and the natural decay series data which imply groundwater groundwater/rock interaction in the last 10{sup 5} a. When integrated with the novel data currently being produced in the BIGRAD project, the CNAP data tend to indicate that any long-term bentonite reaction in low alkali cement leachates is minimal. (orig.)

ACOUSTIC SCALE FROM THE ANGULAR POWER SPECTRA OF SDSS-III DR8 PHOTOMETRIC LUMINOUS GALAXIES

Energy Technology Data Exchange (ETDEWEB)

Seo, Hee-Jong [Berkeley Center for Cosmological Physics, LBL and Department of Physics, University of California, Berkeley, CA 94720 (United States); Ho, Shirley; White, Martin; Reid, Beth; Schlegel, David J. [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Cuesta, Antonio J.; Padmanabhan, Nikhil [Yale Center for Astronomy and Astrophysics, Yale University, New Haven, CT 06511 (United States); Ross, Ashley J.; Percival, Will J.; Nichol, Robert C. [Institute of Cosmology and Gravitation, Dennis Sciama Building, University of Portsmouth, Portsmouth PO1 3FX (United Kingdom); Saito, Shun [Department of Astronomy, 601 Campbell Hall, University of California at Berkeley, Berkeley, CA 94720 (United States); De Putter, Roland [Instituto de Fisica Corpuscular, Valencia (Spain); Eisenstein, Daniel J. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, MS 20, Cambridge, MA 02138 (United States); Xu Xiaoying; Skibba, Ramin [Steward Observatory, University of Arizona, 933 North Cherry Avenue, Tucson, AZ 85721 (United States); Schneider, Donald P. [Institute for Gravitation and the Cosmos, The Pennsylvania State University, University Park, PA 16802 (United States); Verde, Licia [Institucio Catalana de Recerca i Estudis Avancats, Barcelona (Spain); Bizyaev, Dmitry; Brewington, Howard; Brinkmann, J. [Apache Point Observatory, 2001 Apache Point Road, Sunspot, NM 88349 (United States); and others

2012-12-10

We measure the acoustic scale from the angular power spectra of the Sloan Digital Sky Survey III (SDSS-III) Data Release 8 imaging catalog that includes 872, 921 galaxies over {approx}10,000 deg{sup 2} between 0.45 < z < 0.65. The extensive spectroscopic training set of the Baryon Oscillation Spectroscopic Survey luminous galaxies allows precise estimates of the true redshift distributions of galaxies in our imaging catalog. Utilizing the redshift distribution information, we build templates and fit to the power spectra of the data, which are measured in our companion paper, to derive the location of Baryon acoustic oscillations (BAOs) while marginalizing over many free parameters to exclude nearly all of the non-BAO signal. We derive the ratio of the angular diameter distance to the sound horizon scale D{sub A} (z)/r{sub s} = 9.212{sup +0.416}{sub -{sub 0.404}} at z = 0.54, and therefore D{sub A} (z) = 1411 {+-} 65 Mpc at z = 0.54; the result is fairly independent of assumptions on the underlying cosmology. Our measurement of angular diameter distance D{sub A} (z) is 1.4{sigma} higher than what is expected for the concordance {Lambda}CDM, in accordance to the trend of other spectroscopic BAO measurements for z {approx}> 0.35. We report constraints on cosmological parameters from our measurement in combination with the WMAP7 data and the previous spectroscopic BAO measurements of SDSS and WiggleZ. We refer to our companion papers (Ho et al.; de Putter et al.) for investigations on information of the full power spectrum.

Small Scale Electrical Power Generation from Heat Co-Produced in Geothermal Fluids: Mining Operation

Energy Technology Data Exchange (ETDEWEB)

Clark, Thomas M. [ElectraTherm Inc., Reno, NV (United States); Erlach, Celeste [ElectraTherm Inc., Reno, NV (United States)

2014-12-30

Demonstrate the technical and economic feasibility of small scale power generation from low temperature co-produced fluids. Phase I is to Develop, Design and Test an economically feasible low temperature ORC solution to generate power from lower temperature co-produced geothermal fluids. Phase II &III are to fabricate, test and site a fully operational demonstrator unit on a gold mine working site and operate, remotely monitor and collect data per the DOE recommended data package for one year.

Power Controllability of Three-phase Converter with Unbalanced AC Source

DEFF Research Database (Denmark)

Ma, Ke; Chen, Wenjie; Liserre, Marco

2015-01-01

Three-phase DC-AC power converters suffer from power oscillation and overcurrent problems in case of unbalanced AC source voltage that can be caused by grid/generator faults. Existing solutions to handle these problems are properly selecting and controlling the positive and negative sequence...... currents. In this work a new series of control strategies which utilize the zerosequence components are proposed to enhance the power control ability under this adverse condition. It is concluded that by introducing proper zero sequence current controls and corresponding circuit configurations, the power...... converter can enable more flexible control targets, achieving better performances in the delivered power and load current when suffering from unbalanced AC voltage....

Three Phase Six-Switch PWM Buck Rectifier with Power Factor Improvement

DEFF Research Database (Denmark)

Zafar Ullah Khan, M; Mohsin Naveed, M.; Hussain, Dil Muhammad Akbar

2013-01-01

Conventional Phase Controlled Rectifier injects low order current harmonics into the AC mains. Large size filtering components are required to attenuate these harmonics. In this paper, Three Phase Six-Switch PWM Buck Rectifier[1] is presented which operates at nearly unity power factor and provides...

Biomass power for rural development: Phase 2. Technical progress report, April 1--June 30, 1998

Energy Technology Data Exchange (ETDEWEB)

Neuhauser, E.

1998-11-01

The project undertaken by the Salix Consortium is a multi-phased, multi-partner endeavor. Phase-1 focused on initial development and testing of the technology and agreements necessary to demonstrate commercial willow production in Phase-2. The Phase-1 objectives have been successfully completed: preparing final design plans for two utility pulverized coal boilers, developing fuel supply plans for the project, obtaining power production commitments from the power companies for Phase-2, obtaining construction and environmental permits, and developing an experimental strategy for crop production and power generation improvements needed to assure commercial success. The R and D effort also addresses environmental issues pertaining to introduction of the willow energy system. Beyond those Phase-1 requirements the Consortium has already successfully demonstrated cofiring at Greenidge Station and developed the required nursery capacity for acreage scale-up. This past summer 105 acres were prepared in advance for the spring planting in 1998. Having completed the above tasks, the Consortium is well positioned to begin Phase-2. In phase-2 every aspect of willow production and power generation from willow will be demonstrated. The ultimate objective of Phase-2 is to transition the work performed under the Rural Energy for the Future project into a thriving, self-supported energy crop enterprise.

Effect of Population III Multiplicity on Dark Star Formation

Science.gov (United States)

Stacy, Athena; Pawlik, Andreas H.; Bromm, Volker; Loeb, Abraham

2012-01-01

We numerically study the mutual interaction between dark matter (DM) and Population III (Pop III) stellar systems in order to explore the possibility of Pop III dark stars within this physical scenario. We perform a cosmological simulation, initialized at z approx. 100, which follows the evolution of gas and DM. We analyze the formation of the first mini halo at z approx. 20 and the subsequent collapse of the gas to densities of 10(exp 12)/cu cm. We then use this simulation to initialize a set of smaller-scale 'cut-out' simulations in which we further refine the DM to have spatial resolution similar to that of the gas. We test multiple DM density profiles, and we employ the sink particle method to represent the accreting star-forming region. We find that, for a range of DM configurations, the motion of the Pop III star-disk system serves to separate the positions of the protostars with respect to the DM density peak, such that there is insufficient DM to influence the formation and evolution of the protostars for more than approx. 5000 years. In addition, the star-disk system causes gravitational scattering of the central DM to lower densities, further decreasing the influence of DM over time. Any DM-powered phase of Pop III stars will thus be very short-lived for the typical multiple system, and DM will not serve to significantly prolong the life of Pop III stars.

Long-Term Management Strategy for Dredged Material Disposal for Naval Facilities at Pearl Harbor, Hawaii Phase III - Analysis of Alternatives and Development of an LTMS

National Research Council Canada - National Science Library

Palermo, Michael

2000-01-01

This report documents Phase III of a three-phase study to develop a Long-Term Management Study for disposal of dredged material unsuitable for ocean disposal from Pearl Harbor Naval Complex for the next 30 years...

Strong enhancement of streaming current power by application of two phase flow

NARCIS (Netherlands)

Xie, Yanbo; Sherwood, John D.; Shui, Lingling; van den Berg, Albert; Eijkel, Jan C.T.

2011-01-01

We show that the performance of a streaming-potential based microfluidic energy conversion system can be strongly en-hanced by the use of two phase flow. In single-phase systems, the internal conduction current induced by the streaming poten-tial limits the output power, while in a two-phase system

Commissioning of Qinshan phase III PHWR nuclear power plant (2 x 700 MW)

International Nuclear Information System (INIS)

Gu Jun

2004-12-01

As the first CANDU type NPP built in China, the commissioning team established a very efficient and high standard commissioning management system. Unit 1 was put into commercial operation 43 days in advance and 112 days ahead of schedule for Unit 2. Commissioning quality achieved international advanced level. The commissioning period created new world history record of heavy water nuclear power plants. A summary for the practice and the experience of TQNPC obtained in the commissioning of the two unit was given. (authors)

Two-phase flow in porous media: power-law scaling of effective permeability

Energy Technology Data Exchange (ETDEWEB)

Groeva, Morten; Hansen, Alex, E-mail: Morten.Grova@ntnu.no, E-mail: Alex.Hansen@ntnu.no [Department of Physics, NTNU, NO-7491 Trondheim (Norway)

2011-09-15

A recent experiment has reported power-law scaling of effective permeability of two-phase flow with respect to capillary number for a two-dimensional model porous medium. In this paper, we consider the simultaneous flow of two phases through a porous medium under steady-state conditions, fixed total flow-rate and saturation, using a two-dimensional network simulator. We obtain power-law exponents for the scaling of effective permeability with respect to capillary number. The simulations are performed both for viscosity matched fluids and for a high viscosity ratio resembling that of air and water. Good power-law behaviour is found for both cases. Different exponents are found, depending on saturation.

Investigation of Power Losses of Two-Stage Two-Phase Converter with Two-Phase Motor

Directory of Open Access Journals (Sweden)

Michal Prazenica

2011-01-01

Full Text Available The paper deals with determination of losses of two-stage power electronic system with two-phase variable orthogonal output. The simulation is focused on the investigation of losses in the converter during one period in steady-state operation. Modeling and simulation of two matrix converters with R-L load is shown in the paper. The simulation results confirm a very good time-waveform of the phase current and the system seems to be suitable for low-cost application in automotive/aerospace industries and in application with high frequency voltage sources.

Power Prediction and Technoeconomic Analysis of a Solar PV Power Plant by MLP-ABC and COMFAR III, considering Cloudy Weather Conditions

Directory of Open Access Journals (Sweden)

M. Khademi

2016-01-01

Full Text Available The prediction of power generated by photovoltaic (PV panels in different climates is of great importance. The aim of this paper is to predict the output power of a 3.2 kW PV power plant using the MLP-ABC (multilayer perceptron-artificial bee colony algorithm. Experimental data (ambient temperature, solar radiation, and relative humidity was gathered at five-minute intervals from Tehran University’s PV Power Plant from September 22nd, 2012, to January 14th, 2013. Following data validation, 10665 data sets, equivalent to 35 days, were used in the analysis. The output power was predicted using the MLP-ABC algorithm with the mean absolute percentage error (MAPE, the mean bias error (MBE, and correlation coefficient (R2, of 3.7, 3.1, and 94.7%, respectively. The optimized configuration of the network consisted of two hidden layers. The first layer had four neurons and the second had two neurons. A detailed economic analysis is also presented for sunny and cloudy weather conditions using COMFAR III software. A detailed cost analysis indicated that the total investment’s payback period would be 3.83 years in sunny periods and 4.08 years in cloudy periods. The results showed that the solar PV power plant is feasible from an economic point of view in both cloudy and sunny weather conditions.

Utilization of modified corn silk as a biosorbent for solid-phase extraction of Cr(III) and chromium speciation.

Science.gov (United States)

Yu, Hongmei; Pang, Jing; Wu, Mei; Wu, Qiaoli; Huo, Cuixiu

2014-01-01

The ues of corn silk modified with diluted nitric acid (HNO3-MCS) as a novel biosorbent has been established for solid-phase extraction of Cr(III) and chromium speciation in water samples. The functional groups of the HNO3-MCS surface are favorable for the adsorption of Cr(III). Effective extraction conditions were optimized in both batch and column methods. At pH 3.0 - 6.0, a discrimination of Cr(III) and Cr(VI) is achieved on the HNO3-MCS surface. Cr(III) ions are retained onto the HNO3-MCS surface, however, the adsorption of Cr(VI) is negligible under the same conditions. The adsorption isotherm of HNO3-MCS for Cr(III) has been demonstrated in accordance with a linear form of the Langmuir equation, and the maximum adsorption capacity is 35.21 mg g(-1). The well fitted linear regression of the pseudo-second order model showed the indication of a chemisorption mechanism for the entire concentration range. Thermodynamic studies have shown that the adsorption process is spontaneous and endothermic. The adsorbed Cr(III) was quantitatively eluted by a nitric acid solution with detection by flame atomic absorption spectrometry (FAAS). With a sample volume of 30 mL, a detection limit (3σ) of 0.85 μg L(-1) and a precision of 2.0% RSD at the 40 μg L(-1) level were achieved. The concentration of Cr(III) could be accurately quantified within a linear range of 3 - 200 μg L(-1). After Cr(VI) has been reduced to Cr(III) with hydroxylamine hydrochloride, the total amount of chromium was obtained, and the content of Cr(VI) was given by subtraction. The procedure was validated by analyzing chromium in a certified reference material (GBW (E) 080039). It was also successfully applied for the speciation of chromium in wastewater samples.

The future of nuclear power in France: an analysis of the costs of phasing-out

International Nuclear Information System (INIS)

Malischek, Raimund; Trüby, Johannes

2016-01-01

Nuclear power is an important pillar in electricity generation in France. However, the French nuclear power plant fleet is ageing, and the possibility of reducing the technology's share in power generation or even a complete phase-out has been increasingly discussed. This paper focuses on three inter-related questions: First, what are the costs of phasing-out nuclear power in France? Second, who has to bear these costs, i.e., how much of the costs will be passed on to the rest of the European power system? And third, what effect does the uncertainty regarding future nuclear policy in France have on system costs? Applying a stochastic optimization model for the European electricity system, the analysis showed that additional system costs in France of a nuclear phase-out amount up to 76 billion €_2_0_1_0. Additional costs are mostly borne by the French power system. Surprisingly, the analysis found that the costs of uncertainty are rather limited. Based on the results, it can be concluded that a commitment regarding nuclear policy reform is only mildly beneficial in terms of system cost savings. - Highlights: • Analysis of different nuclear policy and phase-out scenarios in France. • Nuclear policy uncertainty in France is treated using stochastic programming. • Costs of a nuclear phase-out in France are significant, amounting up to 76 bill €. • Costs of a phase-out are hardly passed on to the rest of the European power system. • Costs of uncertainty are low, implying little benefit of nuclear policy commitment.

Power Controllability of Three-phase Converter with Unbalanced AC Source

DEFF Research Database (Denmark)

Ma, Ke; Liserre, Marco; Blaabjerg, Frede

2013-01-01

Three-phase DC-AC power converters suffer from power oscillation and overcurrentt problems in case of unbalanced AC source voltage that can be caused by grid/generator faults. Existing solutions to handle these problems are properly selecting and controlling the positive and negative sequence...... currents. In this work a new series of control strategies which utilize the zero-sequence components are proposed to enhance the power control ability under this adverse conditions. It is concluded that by introducing proper zero sequence current controls and corresponding circuit configurations, the power...... converter can enable more flexible control targets, achieving better performances in the delivered power and load current when suffering from unbalanced AC sources....

Experimental analysis of the power curve sensitivity test series at ROSA-III

International Nuclear Information System (INIS)

Koizumi, Y.; Iriko, M.; Yonomoto, T.; Tasaka, K.

1985-01-01

The rig of safety assessment (ROSA)-III facility is a volumetrically scaled (1/424) boiling water reactor (BWR/6) system with an electrically heated core designed for integral LOCA and ECCS tests. Seven recirculation pump suction line break LOCA experiments were conducted at the ROSA-III facility in order to examine the effect of the initial stored heat of a fuel rod on the peak cladding temperature (PCT). The break size was changed from 200% to 5% in the test series and a failure of a high pressure core spray (HPCS) diesel generator was assumed. Three power curves which represented conservative, realistic and zero initial stored heat, respectively, were used. In a large break LOCA such as 200% or 50% breaks, the initial stored heat in a fuel rod has a large effect on the cladding surface temperature because core uncovery occurs before all the initial stored heat is released, whereas in a small break LOCA such as a 5% break little effect is observed because core uncovery occurs after the initial stored heat is released. The maximum PCTs for the conservative initial stored heat case was 925 K, obtained in the 50% break experiment, and that for the realistic initial stored heat case was 835 K, obtained in the 5% break experiment. (orig./HP)

Digital regulation of a phase controlled power converter

International Nuclear Information System (INIS)

Schultheiss, C.; Haque, T.

1995-01-01

The Relativistic Heavy Ion Collider, now in construction at Brookhaven National Laboratory, will use phase controlled power converters for the main dipole and quadrupole magnet strings. The rectifiers in these power supplies will be controlled by a digital regulator based on the TI 320C30 Digital Signal Processor (DSP). The DSP implements the current loop, the voltage loop, and a system to actively reduce the sub-harmonic ripple components. Digital firing circuits consisting of a phase locked lop and counters are used to fire the SCRs. Corrections for the sub-harmonic reduction are calculated by the DSP and stored in registers in the firing circuit. These corrections are added in hardware, to the over-all firing count provided by the DSP. the resultant count is compared to a reference counter to fire the SCRs. This combination of a digital control system and the digital firing circuits allows the correction of the sub-harmonics in a real-time sense. A prototype of the regulator has been constructed, and the preliminary testing indicates a sub-harmonic reduction of 60 dB

Energy market impacts of nuclear power phase-out policies

OpenAIRE

Glomsrød, Solveig; Wei, Taoyuan; Mideksa, Torben; Samset, Bjørn Hallvard

2014-01-01

This is an accepted manuscript of an article published by Springer Netherlands. The final publication is available at link.springer.com via /https://doi.org/10.1007/s11027-014-9558-3 Since the Fukushima disaster in Japan in March 2011, safety concerns have escalated and policies toward nuclear power are being reconsidered in several countries. This article presents a study of the upward pressure on regional electricity prices from nuclear power phase out in four scenarios with various leve...

Beaver Valley Unit 1, United States of America, 2007. Annex III. Description of Selected Open Phase Events

International Nuclear Information System (INIS)

2016-01-01

On 27 Nov. 2007, during a non-routine walkdown of the off-site switchyard to investigate line voltage differences, the licensee discovered that the Phase A conductor of a 138 kV off-site power circuit of the Beaver Valley Power Station Unit 1 had broken off in the switchyard. This break occurred between the off-site feeder breaker and the line running on-site to the A train system station service transformer, located inside the site security fence. The terminal broke on the switchyard side of a revenue-metering current transformer/voltage transformer installed in 2006 to track the station’s power usage through this line. During normal power operation, no appreciable current goes through this 138 kV line because the unit generator normally powers the station buses (loads). The licensee determined that the break on the 138 kV Phase A had occurred 26 days earlier and, therefore, had not been restored within 72 h as required by technical specifications.

Neuro-diffuse algorithm for neutronic power identification of TRIGA Mark III reactor; Algoritmo neuro-difuso para la identificacion de la potencia neutronica del reactor Triga Mark III

Energy Technology Data Exchange (ETDEWEB)

Rojas R, E.; Benitez R, J. S. [Instituto Tecnologico de Toluca, Division de Estudios de Posgrado e Investigacion, Av. Tecnologico s/n, Ex-Rancho La Virgen, 50140 Metepec, Estado de Mexico (Mexico); Segovia de los Rios, J. A.; Rivero G, T. [ININ, Gerencia de Ciencias Aplicadas, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)], e-mail: jorge.benitez@inin.gob.mx

2009-10-15

In this work are presented the results of design and implementation of an algorithm based on diffuse logic systems and neural networks like method of neutronic power identification of TRIGA Mark III reactor. This algorithm uses the punctual kinetics equation as data generator of training, a cost function and a learning stage based on the descending gradient algorithm allow to optimize the parameters of membership functions of a diffuse system. Also, a series of criteria like part of the initial conditions of training algorithm are established. These criteria according to the carried out simulations show a quick convergence of neutronic power estimated from the first iterations. (Author)

Power loss benchmark of nine-switch converters in three-phase online-UPS application

DEFF Research Database (Denmark)

Qin, Zian; Loh, Poh Chiang; Blaabjerg, Frede

2014-01-01

Three-phase online-UPS is an appropriate application for the nine-switch converter, where its high voltage stress of the power device caused by the reduced switch feature can be relieved significantly. Its power loss and loss distribution still have the flexibility from the control point of view...... as parameters like modulation index and phase angle of the load are taken into account. The benchmark of power loss will become a guidance for the users to make best use of the advantages and bypass the disadvantages of nine-switch converters. The results are finally verified on a 1.5 kW prototype....

Heterogeneous FDG-guided dose-escalation for locally advanced NSCLC (the NARLAL2 trial): Design and early dosimetric results of a randomized, multi-centre phase-III study

DEFF Research Database (Denmark)

Møller, Ditte Sloth; Nielsen, Tine Bjørn; Brink, Carsten

2017-01-01

Background and purpose: Local recurrence is frequent in locally advanced NSCLC and is primarily located in FDG-avid parts of tumour and lymph nodes. Aiming at improving local control without increasing toxicity, we designed a multi-centre phase-III trial delivering inhomogeneous dose-escalation d......Background and purpose: Local recurrence is frequent in locally advanced NSCLC and is primarily located in FDG-avid parts of tumour and lymph nodes. Aiming at improving local control without increasing toxicity, we designed a multi-centre phase-III trial delivering inhomogeneous dose...

Extraction behaviour of Am(III) and Eu(III) from nitric acid medium in CMPO-HDEHP impregnated resins

Energy Technology Data Exchange (ETDEWEB)

Saipriya, K.; Kumar, T. [Bhabha Atomic Research Centre Facilities (India). Kalpakkam Reproscessing Plants; Kumaresan, R.; Nayak, P.K.; Venkatesan, K.A.; Antony, M.P. [Indira Gandhi Center for Atomic Research, Kalpakkam (India). Fuel Chemistry Div.

2016-05-01

Chromatographic resin containing extractants such as octyl(phenyl)-N,N-diisobutylcarbamoylmethylphosphine oxide (CMPO) or bis-(2-ethylhexyl)phosphoric acid (HDEHP) or mixture of extractants (CMPO + HDEHP) in an acrylic polymer matrix was prepared and studied for the extraction of Am(III) and Eu(III) over a range of nitric acid concentration. The effect of various parameters such as concentration of nitric acid in aqueous phase and the concentration of CMPO and HDEHP in the resin phase was studied. The distribution coefficient of Am(III) and Eu(III) in the impregnated resin increased with increased in the concentration of nitric acid for CMPO-impregnated resin, whereas a reverse trend was observed in HDEHP impregnated resin. In case of resin containing both the extractants, synergism was observed at low nitric acid concentration and antagonism at high nitric acid concentration. The mechanism of extraction was probed by slope analysis method at 0.01 and 2 M nitric acid concentrations. Citrate-buffered DTPA was used for the selective separation of Am(III), and a separation factor of 3-4 was obtained at pH 3.

Rape embryogenesis. III. Embryo development in time

Directory of Open Access Journals (Sweden)

Teresa Tykarska

2014-01-01

Full Text Available It was found that the growth curve of the rape embryo axis is of triple sigmoid type. Embryo growth occurs in 3 phases corresponding to 3 different periods of development. Phase I includes growth of the apical cell up to it's division into two layers of octants. Phase II comprises the increase of the spherical proembryo to the change of its symmetry from radial to bilateral. Phase III includes, growth of the embryo from the heart stage up to the end of embryogenesis. In each phase the relative growth rate increases drastically and then diminishes. The differences in growth intensity during the same phase are several-fold. The growth intensity maximum of the embryo axis occurs in phase II. The phasic growth intensity maxima occur: in phase I during apical cell elongation, :before its division, and in phases II and III in the periods of cell division ;growth in globular and torpedo-shaped -shaped embryos.

Demonstration of a Variable Phase Turbine Power System for Low Temperature Geothermal Resources

Energy Technology Data Exchange (ETDEWEB)

Hays, Lance G

2014-07-07

A variable phase turbine assembly will be designed and manufactured having a turbine, operable with transcritical, two-phase or vapor flow, and a generator – on the same shaft supported by process lubricated bearings. The assembly will be hermetically sealed and the generator cooled by the refrigerant. A compact plate-fin heat exchanger or tube and shell heat exchanger will be used to transfer heat from the geothermal fluid to the refrigerant. The demonstration turbine will be operated separately with two-phase flow and with vapor flow to demonstrate performance and applicability to the entire range of low temperature geothermal resources. The vapor leaving the turbine is condensed in a plate-fin refrigerant condenser. The heat exchanger, variable phase turbine assembly and condenser are all mounted on single skids to enable factory assembly and checkout and minimize installation costs. The system will be demonstrated using low temperature (237F) well flow from an existing large geothermal field. The net power generated, 1 megawatt, will be fed into the existing power system at the demonstration site. The system will demonstrate reliable generation of inexpensive power from low temperature resources. The system will be designed for mass manufacturing and factory assembly and should cost less than $1,200/kWe installed, when manufactured in large quantities. The estimated cost of power for 300F resources is predicted to be less than 5 cents/kWh. This should enable a substantial increase in power generated from low temperature geothermal resources.

Power Swing Detection in UPFC-Compensated Line by Phase Angle of Current

DEFF Research Database (Denmark)

Khodaparast, Jalal; Khederzadeh, M.; Silva, Filipe Miguel Faria da

2017-01-01

Power swing blocker (PSB) is a complementary part of distance relay protection, that detects power swing, in order to prevent unintended operation of a distance relay. Unified power flow controller (UPFC) is used in power system to control both active and reactive powers and its operation during...... condition. The results show that these indices may no longer work in systems with UPFC. In addition, this paper proposes a new method for detecting power swing based on the phase angle of current at relay point and compares it with two other methods. The new method distinguishes power swing from a fault...

Adaptive fuzzy control of neutron power of the TRIGA Mark III reactor; Control difuso adaptable de la potencia neutronica del reactor Triga Mark III

Energy Technology Data Exchange (ETDEWEB)

Rojas R, E.

2014-07-01

The design and implementation of an identification and control scheme of the TRIGA Mark III research nuclear reactor of the Instituto Nacional de Investigaciones Nucleares (ININ) of Mexico is presented in this thesis work. The identification of the reactor dynamics is carried out using fuzzy logic based systems, in which a learning process permits the adjustment of the membership function parameters by means of techniques based on neural networks and bio-inspired algorithms. The resulting identification system is a useful tool that allows the emulation of the reactor power behavior when different types of insertions of reactivity are applied into the core. The identification of the power can also be used for the tuning of the parameters of a control system. On the other hand, the regulation of the reactor power is carried out by means of an adaptive and stable fuzzy control scheme. The control law is derived using the input-output linearization technique, which permits the introduction of a desired power profile for the plant to follow asymptotically. This characteristic is suitable for managing the ascent of power from an initial level n{sub o} up to a predetermined final level n{sub f}. During the increase of power, a constraint related to the rate of change in power is considered by the control scheme, thus minimizing the occurrence of a safety reactor shutdown due to a low reactor period value. Furthermore, the theory of stability in the sense of Lyapunov is used to obtain a supervisory control law which maintains the power error within a tolerance region, thus guaranteeing the stability of the power of the closed loop system. (Author)

Indirect Control of a low power Single-Phase Active Power Filter

Directory of Open Access Journals (Sweden)

SILVIU EPURE

2010-12-01

Full Text Available This paper deals with a low power, single phase active filter used to compensate nonlinear loads. The filter uses the indirect control method and it is based on a particular connection between filter, polluting load and grid to avoid timeconsuming mathematic operations or signal processing computations and assures good rejection of harmonic currents injected by the nonlinear load into the grid. A scale model was first simulated in Simulink and then physically implemented. The paper presents simulation and experimental results, and highlight problems encountered during experiments.

On the structure and phase transitions of power-law Poissonian ensembles

Science.gov (United States)

Eliazar, Iddo; Oshanin, Gleb

2012-10-01

Power-law Poissonian ensembles are Poisson processes that are defined on the positive half-line, and that are governed by power-law intensities. Power-law Poissonian ensembles are stochastic objects of fundamental significance; they uniquely display an array of fractal features and they uniquely generate a span of important applications. In this paper we apply three different methods—oligarchic analysis, Lorenzian analysis and heterogeneity analysis—to explore power-law Poissonian ensembles. The amalgamation of these analyses, combined with the topology of power-law Poissonian ensembles, establishes a detailed and multi-faceted picture of the statistical structure and the statistical phase transitions of these elemental ensembles.

SPS-ALPHA: The First Practical Solar Power Satellite via Arbitrarily Large PHased Array

Data.gov (United States)

National Aeronautics and Space Administration — SPS-ALPHA (Solar Power Satellite via Arbitrarily Large Phased Array) is a novel, bio-mimetic approach to the challenge of space solar power. If successful, this...

Comparative analysis of SLB for OPR1000 by using MEDUSA and CESEC-III codes

International Nuclear Information System (INIS)

Park, Jong Cheol; Park, Chan Eok; Kim, Shin Whan

2005-01-01

The MEDUSA is a system thermal hydraulics code developed by Korea Power Engineering Company (KOPEC) for Non-LOCA and LOCA analysis, using two fluid, three-field governing equations for two phase flow. The detailed descriptions for the MEDUSA code are given in Reference. A lot of effort is now being made to investigate the applicability of the MEDUSA code especially to Non-LOCA analysis, by comparing the analysis results with those from the current licensing code, CESEC-III: The comparative simulations of Pressurizer Level Control System(PLCS) Malfunction and Feedwater Line Break(FLB), which have been accomplished by C.E.Park and M.T.Oh, respectively, already showed that the MEDUSA code is applicable to the analysis of Non-LOCA events. In this paper, detailed thermal hydraulic analyses for Steam Line Break(SLB) without loss of off-site power were performed using the MEDUSA code. The calculation results were also compared with the CESEC-III, 1000(OPR1000), for the purpose of the code verification

Project 8, Phase III Design: Placing an eV-Scale Limit on the Neutrino Mass using Cyclotron Radiation Emission Spectroscopy

Science.gov (United States)

Oblath, Noah; Project 8 Collaboration

2016-09-01

We report on the design concept for Phase III of the Project 8 experiment. In the third phase of Project 8 we aim to place a limit on the neutrino mass that is similar to the current limits set by tritium beta-decay experiments, mν radioastronomy will be employed to search for and track electron signals in the fiducial volume. This talk will present the quantitative design concept for the phased-array receiver, and illustrate how we are progressing towards the Phase IV experiment, which will have sensitivity to the neutrino mass scale allowed by the inverted mass hierarchy. This work is supported by the DOE Office of Science Early Career Research Program, and the Laboratory Directed Research and Development Program at Pacific Northwest National Laboratory.

Investor Outlook: Significance of the Positive LCA2 Gene Therapy Phase III Results.

Science.gov (United States)

Schimmer, Joshua; Breazzano, Steven

2015-12-01

Spark Therapeutics recently reported positive phase III results for SPK-RPE65 targeting the treatment of visual impairment caused by RPE65 gene mutations (often referred to as Leber congenital amaurosis type 2, or LCA2, but may include other retinal disorders), marking an important inflection point for the field of gene therapy. The results highlight the ability to successfully design and execute a randomized trial of a gene therapy and also reinforce the potentially predictive nature of early preclinical and clinical data. The results are expected to pave the way for the first approved gene therapy product in the United States and should sustain investor interest and confidence in gene therapy for many approaches, including retina targeting and beyond.

A randomized placebo-controlled phase III trial of oral laquinimod for multiple sclerosis

DEFF Research Database (Denmark)

Vollmer, T L; Sorensen, P S; Selmaj, K

2014-01-01

The phase III placebo-controlled BRAVO study assessed laquinimod effects in patients with relapsing-remitting MS (RRMS), and descriptively compared laquinimod with interferon beta (IFNβ)-1a (Avonex(®) reference arm). RRMS patients age 18-55 years with Expanded Disability Status Scale (EDSS) scores...... months. The primary endpoint was annualized relapse rate (ARR); secondary endpoints included percent brain volume change (PBVC) and 3-month confirmed disability worsening. In all, 1,331 patients were randomized: laquinimod (n = 434), placebo (n = 450), and IFNβ-1a (n = 447). ARR was not significantly...... reduced with laquinimod [-18 %, risk ratio (RR) = 0.82, 95 % CI 0.66-1.02; p = 0.075] vs. placebo. Laquinimod significantly reduced PBVC (28 %, p change in confirmed disability worsening with laquinimod measured...

The Effects of PECS Teaching to Phase III on the Communicative Interactions between Children with Autism and Their Teachers

Science.gov (United States)

Carr, Deborah; Felce, Janet

2007-01-01

The study investigated the impact of mastery of the Picture Exchange Communication System (PECS) to Phase III, on the communications of children with autism. Children aged between 3 and 7 years, formed a PECS intervention group and a non-intervention control group. The intervention group received 15 h of PECS teaching over 5 weeks. Three 2-h…

Phenomenology of Polymorphism, III: p, TDiagram and Stability of Piracetam Polymorphs

Science.gov (United States)

Céolin, R.; Agafonov, V.; Louër, D.; Dzyabchenko, V. A.; Toscani, S.; Cense, J. M.

1996-02-01

The nootropic drug Piracetam is known to crystallize in three phases. In order to obtain their stability hierarchy from sublimation pressure inequalities, the drawing of a topologicalp,Tdiagram was attempted. For such a purpose and also for quality control, crystallographic and thermodynamic data were required. Powder X-ray diffractometry (XRD) and differential scanning calorimetry (DSC) were used. Molecular energy calculations were performed. Phase I melts at 426 K (ΔfusH(I) = +180 J·g-1). Phase II transforms into Phase I at 399 K (Δ(II→I)H= +24 J·g-1). Phase III transforms into phase I at 392 K (Δ(III→I)H= +28 J·g-1) or melts at 412 K (ΔfusH(III) = +210 J·g-1). Thep,Tdiagram shows that phase I is stable at higher temperature and phase II at lower temperature, like phase III, which is stable under high pressure. At room temperature, phase II is the more stable form, and phase I the less stable one. This agrees with the spontaneous I → II transformation observed at 298 K within a few hours, and with lattice energies, calculated previously. Molecular energy calculations and crystal structure comparison show how intermolecular hydrogen bonds and H-bonded dimers, in phases II and III, may stabilize conformations higher in energy than those of the isolated molecule and of phase I.

A phase III trial of zoladex and flutamide versus orchiectomy in the treatment of patients with advanced carcinoma of the prostate

DEFF Research Database (Denmark)

Iversen, P; Christensen, M G; Friis, E

1990-01-01

In a multicenter Phase III trial 264 patients with advanced prostatic cancer were randomized to either bilateral orchiectomy or treatment with zoladex supplemented by flutamide. Presently, median follow-up time is 30 months. A small difference in objective response was recorded in favor of the co......In a multicenter Phase III trial 264 patients with advanced prostatic cancer were randomized to either bilateral orchiectomy or treatment with zoladex supplemented by flutamide. Presently, median follow-up time is 30 months. A small difference in objective response was recorded in favor...... of the combination therapy, whereas no statistically significant difference was found in subjective response to therapy, time to progression, and overall survival. Adverse effects were more commonly encountered in the pharmacologically treated patients. It is concluded that the combination of zoladex plus flutamide...... is not clinically superior to orchiectomy in the treatment of patients with advanced carcinoma of the prostate....

Power sharing algorithm for vector controlled six-phase AC motor with four customary three-phase voltage source inverter drive

Directory of Open Access Journals (Sweden)

Sanjeevikumar Padmanaban

2015-09-01

Full Text Available This paper considered a six-phase (asymmetrical induction motor, kept 30° phase displacement between two set of three-phase open-end stator windings configuration. The drive system consists of four classical three-phase voltage inverters (VSIs and all four dc sources are deliberately kept isolated. Therefore, zero-sequence/homopolar current components cannot flow. The original and effective power sharing algorithm is proposed in this paper with three variables (degree of freedom based on synchronous field oriented control (FOC. A standard three-level space vector pulse width modulation (SVPWM by nearest three vectors (NTVs approach is adopted to regulate each couple of VSIs. The proposed power sharing algorithm is verified by complete numerical simulation modeling (Matlab/Simulink-PLECS software of whole ac drive system by observing the dynamic behaviors in different designed condition. Set of results are provided in this paper, which confirms a good agreement with theoretical development.

The fault monitoring and diagnosis knowledge-based system for space power systems: AMPERES, phase 1

Science.gov (United States)

Lee, S. C.

1989-01-01

The objective is to develop a real time fault monitoring and diagnosis knowledge-based system (KBS) for space power systems which can save costly operational manpower and can achieve more reliable space power system operation. The proposed KBS was developed using the Autonomously Managed Power System (AMPS) test facility currently installed at NASA Marshall Space Flight Center (MSFC), but the basic approach taken for this project could be applicable for other space power systems. The proposed KBS is entitled Autonomously Managed Power-System Extendible Real-time Expert System (AMPERES). In Phase 1 the emphasis was put on the design of the overall KBS, the identification of the basic research required, the initial performance of the research, and the development of a prototype KBS. In Phase 2, emphasis is put on the completion of the research initiated in Phase 1, and the enhancement of the prototype KBS developed in Phase 1. This enhancement is intended to achieve a working real time KBS incorporated with the NASA space power system test facilities. Three major research areas were identified and progress was made in each area. These areas are real time data acquisition and its supporting data structure; sensor value validations; development of inference scheme for effective fault monitoring and diagnosis, and its supporting knowledge representation scheme.

Electrochemical reduction of Eu (III) in propionic media

International Nuclear Information System (INIS)

Brotto, M.E.; Rabockai, T.

1988-01-01

Some chronopotentiometric studies of Eu (III) electro-reducion in propionic media that suggests the presence of two parallel rections: Eu (III) → Eu (II) and Eu (III) → Eu (II) → Y are presented. Some experimental data, such Eu (III) reducion, electrolysis of solutions and ionic power of the system are discussed. (M.J.C.) [pt

DIAGNOSTIC GUIDANCE AND EARLY INTERVENTION IN CLASS III MALOCCLUSION

Directory of Open Access Journals (Sweden)

Rinandri Charea Runizar

2015-06-01

Full Text Available Timing of orthodontic treatment for Class III malocclusion has always been somewhat controversial. Many orthodontic pioneers like Angle, Tweed, and Graber have advocated early interception of class II malocclusion because this kind of skeletal discrepancy once established, would usually progress rapidly. What kind of early treatment would be appropriate for this malocclusion? Would this approach be effective and promises a stable result? Early orthodontic treatment is defined as a treatment that is initiated during the primary or mixed dentition stage to enhance skeletal and dental development. It is usually done in two phases. The first phase is intended to correct skeletal discrepancy by taking advantage of growth and development period. The second phase followed to improve occlusal relationship. Early treatment of Class III malocclusion is a possible alternative to improve skeletal discrepancy or at the very east may serve to prevent a worsening malocclusion. Principles of Class III early treatment depend on whether it is dental Class III, functional Class III, or skeletal Class III. Practitioners should consider positive and negative factors of a patient before initiating treatment. Likewise, they should understand factors that affect prognosis and stability of the results.

Kinetic of liquid-liquid extraction for uranyl nitrate and actinides (III) and lanthanides (III) nitrates by amide extractants

International Nuclear Information System (INIS)

Toulemonde, V.; CEA Centre d'Etudes de la Vallee du Rhone, 30 -Marcoule

1995-01-01

The kinetics of liquid-liquid extraction by amide extractants have been investigated for uranyl nitrate (monoamide extractants), actinides (III) and lanthanides (III) nitrates (diamide extractants). The transfer of the metallic species from the aqueous phase to the organic phase was studied using two experimental devices: ARMOLLEX (Argonne Modified Lewis cell for Liquid Liquid Extraction) and RSC (Rotating Stabilized Cell). The main conclusions are: for the extraction of uranyl nitrate by DEHDMBA monoamide, the rate-controlling step is the complexation of the species at the interface of the two liquids. Thus, an absorption-desorption (according to Langmuir theory) reaction mechanism was proposed; for the extraction of actinides (III) and lanthanides (III) nitrates in nitric acid media by DMDBTDMA diamide, the kinetic is also limited by interfacial reactions. The behavior of Americium and Europium is very similar as fare as their reaction kinetics are concerned. (author)

Correlation of Noise Signature to Pulsed Power Events at the HERMES III Accelerator.

Energy Technology Data Exchange (ETDEWEB)

Lewis, Barbara [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Joseph, Nathan Ryan [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Salazar, Juan Diego [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2016-11-01

The HERMES III accelerator, which is located at Sandia National Laboratories' Tech Area IV, is the largest pulsed gamma X-ray source in the world. The accelerator is made up of 20 inductive cavities that are charged to 1 MV each by complex pulsed power circuitry. The firing time of the machine components ranges between the microsecond and nanosecond timescales. This results in a variety of electromagnetic frequencies when the accelerator fires. Testing was done to identify the HERMES electromagnetic noise signal and to map it to the various accelerator trigger events. This report will show the measurement methods used to capture the noise spectrum produced from the machine and correlate this noise signature with machine events.

Phase III Drilling Operations at the Long Valley Exploratory Well (LVF 51-20)

Energy Technology Data Exchange (ETDEWEB)

Finger, J.T.; Jacobson, R.D.

1999-06-01

During July-September, 1998, a jointly funded drilling operation deepened the Long Valley Exploratory Well from 7178 feet to 9832 feet. This was the third major drilling phase of a project that began in 1989, but had sporadic progress because of discontinuities in tiding. Support for Phase III came from the California Energy Commission (CEC), the International Continental Drilling Program (ICDP), the US Geological Survey (USGS), and DOE. Each of these agencies had a somewhat different agenda: the CEC wants to evaluate the energy potential (specifically energy extraction from magma) of Long Valley Caldera; the ICDP is studying the evolution and other characteristics of young, silicic calderas; the USGS will use this hole as an observatory in their Volcano Hazards program; and the DOE, through Sandia, has an opportunity to test new geothermal tools and techniques in a realistic field environment. This report gives a description of the equipment used in drilling and testing; a narrative of the drilling operations; compiled daily drilling reports; cost information on the project; and a brief summary of engineering results related to equipment performance and energy potential. Detailed description of the scientific results will appear in publications by the USGS and other researchers.

Strong enhancement of straeming current power by application of two phase flow

NARCIS (Netherlands)

Xie, Yanbo; Sherwood, John D.; Shui, Lingling; van den Berg, Albert; Eijkel, Jan C.T.

2011-01-01

We show that the performance of a streaming-potential based microfluidic energy conversion system can be strongly enhanced by the use of two phase flow. Injection of gas bubbles into a liquid-filled channel increases both the maximum output power and the energy conversion efficiency. In single-phase

Acute morbidity reduction using 3DCRT for prostate carcinoma; a randomised phase III study

International Nuclear Information System (INIS)

Koper, P.; Putten, W. van; Stroom, J.; Korevaar, G.; Heijmen, B.; Wijnmaalen, A.; Jansen, P.; Hanssens, P.; Griep, C.; Krol, A.; Samson, M.; Levendag, P.

1997-01-01

Purpose: A randomised phase III toxicity study (conventional vs conformal radiotherapy) was performed for prostatic carcinoma to study the effects on the (acute) morbidity of intestinal/rectosigmoid and bladder. The observed toxicity was compared with Dose Volume Histograms to reveal possible volume (reduction) effects. Methods: In the phase III study 266 T1-4 N0M0 prostate cancer patients were entered. Patients were randomised for conventional and conformal radiotherapy (total dose 66 Gy, minimum PTV dose 95% ICRU and a CTV-PTV margin of 10 mm in both study arms). The GTV was limited to the prostate only in T1 tumors. In all other patients the GTV was defined to be prostate and seminal vesicles for the complete treatment course. The CTV-PTV margin (10mm) was created by a automated program to ensure the minimum prescribed margin. The rectosigmoid was defined to be the rectum including the sigmoid within the Treatment Volume (ICRU). Acute toxicity was evaluated using the EORTC/RTOG morbidity score and weekly quality of life questionnaires. The radiation technique comparison was done by Dose volume Histogram analysis using the Area Under The Curve (AUC) for different dose levels. In this preliminary DVH analysis we present the data for the first 100 patients. Results: Patient and tumor characteristics were evenly distributed between both study groups. The maximum toxicity is reached at 75% of the tumordose (TD) (rectal grade I 59% grade II 26%, bladder grade I 48%, grade II 16% and grade III 1% [catheter for urinary retention]). Comparing both study arms there seems to be a reduction in intestinal morbidity (grade II and higher resp. 32% vs 19% p=0.02). Further analysis revealed a marked reduction in medication for anal symptoms; this accounts for a large part of the significant difference in intestinal toxicity (grade II conventional vs conformal rectosigmoid 18% vs 14% and anal 16% vs 8%). For bladder morbidity no difference for mobidity higher than grade I is

Single-Phase Hybrid Switched Reluctance Motor for Low-Power Low-Cost Applications

DEFF Research Database (Denmark)

Lu, Kaiyuan; Rasmussen, Peter Omand; Jakobsen, Uffe

2011-01-01

This paper presents a new single-phase, Hybrid Switched Reluctance (HSR) motor for low-cost, low-power, pump or fan drive systems. Its single-phase configuration allows use of a simple converter to reduce the system cost. Cheap ferrite magnets are used and arranged in a special flux concentration...... manner to increase effectively the torque density and efficiency of this machine. The efficiency of this machine is comparable to the efficiency of a traditional permanent magnet machine in the similar power range. The cogging torque, due to the existence of the permanent magnetic field, is beneficially...

Hysteroscopic Essure Inserts for Permanent Contraception: Extended Follow-Up Results of a Phase III Multicenter International Study.

Science.gov (United States)

Chudnoff, Scott G; Nichols, John E; Levie, Mark

2015-01-01

To describe safety, tolerability, and effectiveness results through 5 years of follow-up of a Phase III trial with Essure inserts. Multicenter, nonrandomized, single-arm international study (Canadian Task Force classification II-3). Thirteen clinical study centers in the United States, Europe, and Australia. A total of 518 previously fertile women seeking permanent contraception. The objective of the hysteroscopic sterilization procedure was bilateral Essure insert placement (ESS205 model) and tubal occlusion. Women with satisfactory device location and tube occlusion (based on modified hysterosalpingography [HSG]) were instructed to discontinue alternative contraception and to rely on Essure inserts for permanent contraception. The primary endpoint for the Phase III study was the rate of pregnancies occurring during the first year of relying (i.e., HSG-confirmed occlusion) on the Essure inserts for permanent contraception (i.e., 12 months after HSG). For the full 5 years of follow-up (5 years total of relying on the Essure inserts for contraception), the endpoints of interest were safety, prevention of pregnancy, and satisfaction. No pregnancies were reported among women relying on the Essure inserts who completed the full 5 years of follow-up. As of December 5, 2007, 449 women with successful bilateral placement relying on the Essure inserts contributed a total 24 942 woman-months of follow-up for assessing effectiveness. Overall, the Essure inserts were generally well tolerated, with participant comfort rated as "good" to "excellent" by 99% of women (382 of 385) after 5 years of use. Similarly, overall satisfaction was rated as "somewhat" to "very satisfied" by 98% of women (376 of 384) after 5 years of use. The majority of adverse events reported during the 5 years of follow-up were rated as either "mild" or "moderate" in severity. Three severe events (abdominal pain with very heavy periods and irregular menstrual bleeding) were reported in 2 subjects during

A study on the crack inspection signal characteristics for power plant components by phased array UT

International Nuclear Information System (INIS)

Cho, Yong Sang; Lim, Sang Gyu; Kil, Du Song

2001-01-01

Phased array ultrasonic testing system has become available for practical application in complicated geometry such as turbine blade root, tenon, disc in power industry. This research describes the characteristics of phased array UT signal for various type of blade roots in thermal Power Plant turbines. This application of Phased array ultrasonic testing system has been promoted mainly to save inspection time and labor cost of turbine inspection. The characteristic of phase array UT signal for power plant component is very simple to understand but to difficult for perform the inspection. Since our sophisticated inspection technique and systems are essential for the inspection of steam turbine blade roots that require high reliability, we intend to develop new technology and improve phased array technique based on the wide and much experience for the inspection of turbine components.

Evaluate fundamental approaches to longwall dust control. Phase III report

Energy Technology Data Exchange (ETDEWEB)

Babbitt, C.; Bartlett, P.; Kelly, J.; Ludlow, J.; Mangolds, A.; Rajan, S.; Ruggieri, S.; Varga, E.

1984-03-31

The overall objective of the contract is to evaluate the effectiveness of available dust control technology for double-drum shearer longwall sections in a coordinated, systematic program at a few longwall test sections and to make the results available to the entire coal mining industry. This program is investigating nine different dust control techniques. These nine subprograms encompass a broad range of dust control measures ranging from administrative controls to new hardware. They span not only presently employed methods but also those recently adopted in the United States and those proposed for the future. This report documents the Phase III effort on each of the subprograms. For clarity, the report is divided in sections by subprogram as follows: Section 2, Subprogram A - passive barriers/spray air movers for dust control; Section 3, Subprogram B - practical aspects of deep cutting; Section 4, Subprogram C - stage loader dust control; Section 5, Subprogram D - longwall automation technology; Section 6, Subprogram E - longwall application of ventilation curtains; Section 7, Subprogram F - reversed drum rotation; Section 8, Subprogram G - reduction of shield generated dust; Section 9, Subprogram H - air canopies for longwalls; and Section 10, Subprogram I - mining practices. 43 figures, 11 tables.

Analysis of Reasons for fluctuation in seal oil system on generator and countermeasures in Qinshan phase III project

International Nuclear Information System (INIS)

Jin Xiaodong

2012-01-01

Reasons for hydraulic differential fluctuations seal hydrogen oil on generator in Qinshan phase III project were analyzed, provide a basis for modifying Run method is to determine the causes and effects of seal oil flow changes and in the relationship between flow changes and hydraulic differential hydrogen oil changes according to reason Results were analyzed to adjust the running test, to verify the feasibility of running adjustment programs

Bortezomib before and after high-dose therapy in myeloma : Long-term results from the phase III HOVON-65/GMMGHD-4 trial

NARCIS (Netherlands)

Goldschmidt, H.; Lokhorst, H. M.; Mai, E. K.; van der Holt, B.; Blau, I. W.; Zweegman, S.; Weisel, K. C.; Vellenga, E.; Pfreundschuh, M.; Kersten, M. J.; Scheid, C.; Croockewit, S.; Raymakers, R.; Hose, D.; Potamianou, A.; Jauch, A.; Hillengass, J.; Stevens-Kroef, M.; Raab, M. S.; Broijl, A.; Lindemann, H. W.; Bos, G. M. J.; Brossart, P.; Kooy, M. van Marwijk; Ypma, P.; Duehrsen, U.; Schaafsma, R. M.; Bertsch, U.; Hielscher, T.; Jarari, Le; Salwender, H. J.; Sonneveld, P.

The Dutch-Belgian Cooperative Trial Group for Hematology Oncology Group-65/German-speaking Myeloma Multicenter Group-HD4 (HOVON-65/GMMG-HD4) phase III trial compared bortezomib (BTZ) before and after high-dose melphalan and autologous stem cell transplantation (HDM, PAD arm) compared with classical

Bortezomib before and after high-dose therapy in myeloma: long-term results from the phase III HOVON-65/GMMGHD-4 trial

NARCIS (Netherlands)

Goldschmidt, H.; Lokhorst, H. M.; Mai, E. K.; van der Holt, B.; Blau, I. W.; Zweegman, S.; Weisel, K. C.; Vellenga, E.; Pfreundschuh, M.; Kersten, M. J.; Scheid, C.; Croockewit, S.; Raymakers, R.; Hose, D.; Potamianou, A.; Jauch, A.; Hillengass, J.; Stevens-Kroef, M.; Raab, M. S.; Broijl, A.; Lindemann, H. W.; Bos, G. M. J.; Brossart, P.; van Marwijk Kooy, M.; Ypma, P.; Duehrsen, U.; Schaafsma, R. M.; Bertsch, U.; Hielscher, T.; Jarari, Le; Salwender, H. J.; Sonneveld, P.

2018-01-01

The Dutch-Belgian Cooperative Trial Group for Hematology Oncology Group-65/German-speaking Myeloma Multicenter Group-HD4 (HOVON-65/GMMG-HD4) phase III trial compared bortezomib (BTZ) before and after high-dose melphalan and autologous stem cell transplantation (HDM, PAD arm) compared with classical

Production circulator fabrication and testing for core flow test loop. Final report, Phase III

Energy Technology Data Exchange (ETDEWEB)

1981-05-01

The performance testing of two production helium circulators utilizing gas film lubrication is described. These two centrifugal-type circulators plus an identical circulator prototype will be arranged in series to provide the helium flow requirements for the Core Flow Test Loop which is part of the Gas-Cooled Fast Breeder Reactor Program (GCFR) at the Oak Ridge National Laboratory. This report presents the results of the Phase III performance and supplemental tests, which were carried out by MTI during the period of December 18, 1980 through March 19, 1981. Specific test procedures are outlined and described, as are individual tests for measuring the performance of the circulators. Test data and run descriptions are presented.

Production circulator fabrication and testing for core flow test loop. Final report, Phase III

International Nuclear Information System (INIS)

1981-05-01

The performance testing of two production helium circulators utilizing gas film lubrication is described. These two centrifugal-type circulators plus an identical circulator prototype will be arranged in series to provide the helium flow requirements for the Core Flow Test Loop which is part of the Gas-Cooled Fast Breeder Reactor Program (GCFR) at the Oak Ridge National Laboratory. This report presents the results of the Phase III performance and supplemental tests, which were carried out by MTI during the period of December 18, 1980 through March 19, 1981. Specific test procedures are outlined and described, as are individual tests for measuring the performance of the circulators. Test data and run descriptions are presented

Kinetic of liquid-liquid extraction for uranyl nitrate and actinides (III) and lanthanides (III) nitrates by amide extractants; Cinetique d`extraction liquide-liquide du nitrate d`uranyle et des nitrates d`actinides (III) et de lanthanides (III) par des extractants a fonction amide

Energy Technology Data Exchange (ETDEWEB)

Toulemonde, V [CEA Centre d` Etudes Nucleaires de Saclay, 91 -Gif-sur-Yvette (France); [CEA Centre d` Etudes de la Vallee du Rhone, 30 -Marcoule (France). Dept. d` Exploitation du Retraitement et de Demantelement

1995-12-20

The kinetics of liquid-liquid extraction by amide extractants have been investigated for uranyl nitrate (monoamide extractants), actinides (III) and lanthanides (III) nitrates (diamide extractants). The transfer of the metallic species from the aqueous phase to the organic phase was studied using two experimental devices: ARMOLLEX (Argonne Modified Lewis cell for Liquid Liquid Extraction) and RSC (Rotating Stabilized Cell). The main conclusions are: for the extraction of uranyl nitrate by DEHDMBA monoamide, the rate-controlling step is the complexation of the species at the interface of the two liquids. Thus, an absorption-desorption (according to Langmuir theory) reaction mechanism was proposed; for the extraction of actinides (III) and lanthanides (III) nitrates in nitric acid media by DMDBTDMA diamide, the kinetic is also limited by interfacial reactions. The behavior of Americium and Europium is very similar as fare as their reaction kinetics are concerned. (author). 89 refs.

Adsorption of As(III), As(V) and Cu(II) on zirconium oxide immobilized alginate beads in aqueous phase.

Science.gov (United States)

Kwon, Oh-Hun; Kim, Jong-Oh; Cho, Dong-Wan; Kumar, Rahul; Baek, Seung Han; Kurade, Mayur B; Jeon, Byong-Hun

2016-10-01

A composite adsorbent to remove arsenite [As(III)], arsenate [As(V)], and copper [Cu(II)] from aqueous phase was synthesized by immobilizing zirconium oxide on alginate beads (ZOAB). The composition (wt%) of ZOAB (Zr-34.0; O-32.7; C-21.3; Ca-1.0) was confirmed by energy dispersive X-ray (EDX) analysis. Sorption studies were conducted on single and binary sorbate systems, and the effects of contact time, initial adsorbate concentration, and pH on the adsorption performance of ZOAB (pHPZC = 4.3) were monitored. The sorption process for As(III)/As(V) and Cu(II) reached an equilibrium state within 240 h and 24 h, respectively, with maximum sorption capacities of 32.3, 28.5, and 69.9 mg g(-1), respectively. The addition of Cu(II) was favorable for As(V) sorption in contrast to As(III). In the presence of 48.6 mg L(-1) Cu(II), the sorption capacity of As(V) increased from 1.5 to 3.8 mg g(-1) after 240 h. The sorption data for As(III)/As(V) and Cu(II) conformed the Freundlich and Langmuir isotherm models, respectively. The adsorption of As(III), As(V), and Cu(II) followed pseudo second order kinetics. The effect of arsenic species on Cu(II) sorption was insignificant. The results of present study demonstrated that the synthesized sorbent could be useful for the simultaneous removal of both anionic and cationic contaminants from wastewaters. Copyright © 2016 Elsevier Ltd. All rights reserved.

Power sharing algorithm for vector controlled six-phase AC motor with four customary three-phase voltage source inverter drive

DEFF Research Database (Denmark)

Padmanaban, Sanjeevikumar; Grandi, Gabriele; Blaabjerg, Frede

2015-01-01

This paper considered a six-phase (asymmetrical) induction motor, kept 30 phase displacement between two set of three-phase open-end stator windings configuration. The drive system consists of four classical three-phase voltage inverters (VSIs) and all four dc sources are deliberately kept isolated......) by nearest three vectors (NTVs) approach is adopted to regulate each couple of VSIs. The proposed power sharing algorithm is verified by complete numerical simulation modeling (Matlab/ Simulink-PLECS software) of whole ac drive system by observing the dynamic behaviors in different designed condition. Set...

Direct disposal of spent fuel. Simulation of shaft transport. Phase III. Final report

International Nuclear Information System (INIS)

Filbert, W.; Heda, M.; Khamis, M.; Neydek, J.; Niehues, N.; Rissel, J.; Schrimpf, C.; Weber, W.; Fuchs, D.; Gerlach, A.; Langebrake, F.; Sindern, W.; Gasch, A.; Leicht, R.; Schwab, B.; Hecke, R. van; Kipka, P.; Simmich, K.; Weber, H.

1994-01-01

The aim of these demonstration tests was to verify the technical feasibility of a shaft hoisting equipment with a payload of 85 t as well as the safe transport of POLLUX-casks. In phase III of the project the components and the test stand were built, their proper functioning and reliability were tested to demonstrate that they are state-of-the-art. The following additional investigations were carried out: - Tests to fix operational disturbances and simulation tests for the new components to demonstrate their licensibility -Selection and lifetime tests of ropes and investigation of the present state-of-the-art of rope slighting under the conditions of the conceptual design of the shaft hoisting facility - Execution of a probabilistic safety analysis e.g. the determination of the release of radioactive material (result: probability [de

Reactive Power Injection Strategies for Single-Phase Photovoltaic Systems Considering Grid Requirements

DEFF Research Database (Denmark)

Yang, Yongheng; Wang, Huai; Blaabjerg, Frede

2014-01-01

.g. Germany and Italy. Those advanced features can be provided by next generation PV systems, and will be enhanced in the future to ensure an even efficient and reliable utilization of PV systems. In light of this, Reactive Power Injection (RPI) strategies for single-phase PV systems are explored...... in this paper. The RPI possibilities are: a) constant average active power control, b) constant active current control, c) constant peak current control and d) thermal optimized control strategy. All those strategies comply with the currently active grid codes, but are with different objectives. The proposed...... RPI strategies are demonstrated firstly by simulations and also tested experimentally on a 1 kW singe-phase grid-connected system in LVRT operation mode. Those results show the effectiveness and feasibilities of the proposed strategies with reactive power control during LVRT operation. The design...

Analysis of three-phase power-supply systems using computer-aided design programs

International Nuclear Information System (INIS)

Oberst, E.F.

1977-01-01

A major concern of every designer of large, three-phase power-supply systems is the protection of system components from overvoltage transients. At present, three computer-aided circuit design programs are available in the Magnetic Fusion Energy (MFE) National Computer Center that can be used to analyze three-phase power systems: MINI SCEPTRE, SPICE I, and SPICE II. These programs have been used at Lawrence Livermore Laboratory (LLL) to analyze the operation of a 200-kV dc, 20-A acceleration power supply for the High Voltage Test Stand. Various overvoltage conditions are simulated and the effectiveness of system protective devices is observed. The simulated overvoltage conditions include such things as circuit breaker openings, pulsed loading, and commutation voltage surges in the rectifiers. These examples are used to illustrate the use of the computer-aided, circuit-design programs discussed in this paper

Microcontroller Based SPWM Single-Phase Inverter For Wind Power Application

Directory of Open Access Journals (Sweden)

Khin Ohmar Lin

2017-04-01

Full Text Available In this paper microcontroller based sinusoidal pulse width modulation SPWM single-phase inverter is emphasized to constant frequency conversion scheme for wind power application. The wind-power generator output voltage and frequency are fluctuated due to the variation of wind velocity. Therefore the AC output voltage of wind-generator is converted into DC voltage by using rectifier circuit and this DC voltage is converted back to AC voltage by using inverter circuit. SPWM technique is used in inverter to get nearly sine wave and reduce harmonic content. The rating of inverter is 500W single-phase 220V 50 Hz. The required SPWM timing pulses for the inverter are generated from the PIC16F877A microcontroller. Circuit simulation was done by using Proteus 7 Professional and MATLABR 2008 software. The software for microcontroller is implemented by using MPASM assembler.

Phase I-II study of everolimus and low-dose oral cyclophosphamide in patients with metastatic renal cell cancer

International Nuclear Information System (INIS)

Huijts, Charlotte M; Santegoets, Saskia J; Eertwegh, Alfons J van den; Pijpers, Laura S; Haanen, John B; Gruijl, Tanja D de; Verheul, Henk M; Vliet, Hans J van der

2011-01-01

For patients with metastatic renal cell cancer (mRCC) who progressed on vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor therapy, the orally administered mammalian target of rapamycin (mTOR) inhibitor everolimus has been shown to prolong progression free survival. Intriguingly, inhibition of mTOR also promotes expansion of immunosuppressive regulatory T cells (Tregs) that can inhibit anti-tumor immune responses in a clinically relevant way in various tumor types including RCC. This study intends to investigate whether the antitumor efficacy of everolimus can be increased by preventing the detrimental everolimus induced expansion of Tregs using a metronomic schedule of cyclophosphamide. This phase I-II trial is a national multi-center study of different doses and schedules of low-dose oral cyclophosphamide in combination with a fixed dose of everolimus in patients with mRCC not amenable to or progressive after a VEGF-receptor tyrosine kinase inhibitor containing treatment regimen. In the phase I part of the study the optimal Treg-depleting dose and schedule of metronomic oral cyclophosphamide when given in combination with everolimus will be determined. In the phase II part of the study we will evaluate whether the percentage of patients progression free at 4 months of everolimus treatment can be increased from 50% to 70% by adding metronomic cyclophosphamide (in the dose and schedule determined in the phase I part). In addition to efficacy, we will perform extensive immune monitoring with a focus on the number, phenotype and function of Tregs, evaluate the safety and feasibility of the combination of everolimus and cyclophosphamide, perform monitoring of selected angiogenesis parameters and analyze everolimus and cyclophosphamide drug levels. This phase I-II study is designed to determine whether metronomic cyclophosphamide can be used to counter the mTOR inhibitor everolimus induced Treg expansion in patients with metastatic renal cell

Phase I-II study of everolimus and low-dose oral cyclophosphamide in patients with metastatic renal cell cancer

Directory of Open Access Journals (Sweden)

Huijts Charlotte M

2011-11-01

Full Text Available Abstract Background For patients with metastatic renal cell cancer (mRCC who progressed on vascular endothelial growth factor (VEGF receptor tyrosine kinase inhibitor therapy, the orally administered mammalian target of rapamycin (mTOR inhibitor everolimus has been shown to prolong progression free survival. Intriguingly, inhibition of mTOR also promotes expansion of immunosuppressive regulatory T cells (Tregs that can inhibit anti-tumor immune responses in a clinically relevant way in various tumor types including RCC. This study intends to investigate whether the antitumor efficacy of everolimus can be increased by preventing the detrimental everolimus induced expansion of Tregs using a metronomic schedule of cyclophosphamide. Methods/design This phase I-II trial is a national multi-center study of different doses and schedules of low-dose oral cyclophosphamide in combination with a fixed dose of everolimus in patients with mRCC not amenable to or progressive after a VEGF-receptor tyrosine kinase inhibitor containing treatment regimen. In the phase I part of the study the optimal Treg-depleting dose and schedule of metronomic oral cyclophosphamide when given in combination with everolimus will be determined. In the phase II part of the study we will evaluate whether the percentage of patients progression free at 4 months of everolimus treatment can be increased from 50% to 70% by adding metronomic cyclophosphamide (in the dose and schedule determined in the phase I part. In addition to efficacy, we will perform extensive immune monitoring with a focus on the number, phenotype and function of Tregs, evaluate the safety and feasibility of the combination of everolimus and cyclophosphamide, perform monitoring of selected angiogenesis parameters and analyze everolimus and cyclophosphamide drug levels. Discussion This phase I-II study is designed to determine whether metronomic cyclophosphamide can be used to counter the mTOR inhibitor everolimus

A Single-Phase Voltage-Controlled Grid-Connected Photovoltaic System With Power Quality Conditioner Functionality

DEFF Research Database (Denmark)

Kerekes, Tamas; Liserre, Marco; Mastromauro, R. A.

2009-01-01

Future ancillary services provided by photovoltaic (PV) systems could facilitate their penetration in power systems. Also low power PV systems can be designed to improve the power quality. This paper presents a single-phase photovoltaic system that provides grid voltage support and compensation o...

Optimal power flow based on glow worm-swarm optimization for three-phase islanded microgrids

DEFF Research Database (Denmark)

Quang, Ninh Nguyen; Sanseverino, Eleonora Riva; Di Silvestre, Maria Luisa

2014-01-01

This paper presents an application of the Glowworm Swarm Optimization method (GSO) to solve the optimal power flow problem in three-phase islanded microgrids equipped with power electronics dc-ac inverter interfaced distributed generation units. In this system, the power injected by the distribut...

Biomass power for rural development. Technical progress report Phase-II. Contractual reporting period October-December 1999

Energy Technology Data Exchange (ETDEWEB)

Neuhauser, Edward; The Salix Consortium

2000-03-23

The project undertaken by the Salix Consortium is a multi-phased, multi-partner endeavor. Phase 1 focused on initial development and testing of the technology and forging the necessary agreements to demonstrate commercial willow production. The Phase 1 objectives have been successfully completed: preparing design plans for 2 utility pulverized coal boilers for 20 MW of biopower capacity; developing fuel supply plans for the project with a goal of establishing 365 ha (900 ac) of willow; obtaining power production commitments from the power companies for Phase 2; obtaining construction and environmental permits; and developing an experimental strategy for crop production and power generation improvements needed to assure commercial success. The R and D effort also addresses environmental issues pertaining to introduction of the willow energy system.

Power flow evaluations for HERMES III

International Nuclear Information System (INIS)

Smith, D.L.; Ramirez, J.J.; Corley, J.P.; Hasti, D.E.

1985-01-01

A study has been conducted to evaluate the transfer of electro-magnetic pulses from water dielectric strip transmission lines into a diode insulator stack. The HERMES III Scale Model Experiments (HERMEX) included single-stage diodes as well as multistage models in which a variety of parallel/series combinations of strip transmission lines (strip lines) were used to evaluate the voltage adding efficiency at the diode. A technique has been established to estimate an equivalent shunt impedance across the diode due to the nearby uncharged water volume

Simulator of the punctual kinetics of a TRIGA Mark III reactor with power diffuse control in a visual environment

International Nuclear Information System (INIS)

Perez M, C.

2004-01-01

The development of a software is presented that simulates the punctual kinetics of a nuclear reactor of investigation model TRIGA Mark III, generating the answers of the reactor low different algorithms of control of power. The user requires a graphic interface that allows him easily interacting with the simulator. To achieve the proposed objective, first the system was modeled in open loop, not using a mathematical model of the consistent reactor in a system of linear ordinary differential equations. For their solution in real time the numeric method of Runge-Kutta-Fehlberg was used. As second phase, it was modeled to the system in closed loop, using for it an algorithm of control of the power based on fuzzy logic. This software has as purpose to help the investigator in the control area who will be able to prove different algorithms for the control of the power of the reactor. This is achieved using the code source in language C, C++, Visual Basic, with which a file is generated. DLL and it is inserted in the simulator. Then they will be able to visualize the results as if their controller had installed in the reactor, analyzing the behavior of all his variables that will be stored in files, for his later study. The easiness of proving these control algorithms in the reactor without necessity to make it physically has important consequences as the saving in the expense of fuel, the not generation of radioactive waste and the most important thing, one doesn't run any risk. The simulator can be used how many times it is necessary until the total purification of the algorithm. This program is the base for following investigation processes, enlarging the capacities and options of the same one. The program fulfills the time of execution satisfactorily, assisting to the necessity of visualizing the behavior in real time of the reactor, and it responds from an effective way to the petitions of changes of power on the part of the user. (Author)

Spectral Analysis of Instantaneous Power in Single-phase and Three-phase Systems with Use of p-q-r Theory

DEFF Research Database (Denmark)

Kim, Hyosung; Blaabjerg, Frede; Bak-Jensen, Birgitte

2002-01-01

This paper proposes a novel power compensation algorithm in three-phase four-wire systems by using p-q-r theory. The p-q-r theory is compared with two previous instantaneous power theories, p-q theory and cross-vector theory. The p-q-r theory provides two-degrees of freedom to control the system...

Impact of baseline covariates on the immunogenicity of the 9-valent HPV vaccine - A combined analysis of five phase III clinical trials

DEFF Research Database (Denmark)

Petersen, Lone K; Restrepo, Jaime; Moreira, Edson D

2017-01-01

BACKGROUND: The immunogenicity profile of the 9-valent HPV (9vHPV) vaccine was evaluated across five phase III clinical studies conducted in girls and boys 9-15 years of age and young women 16-26 years of age. The effect of baseline characteristics of subjects on vaccine-induced HPV antibody...... responses was assessed. METHODS: Immunogenicity data from 11,304 subjects who received ≥1 dose of 9vHPV vaccine in five Phase III studies were analyzed. Vaccine was administered as a 3-dose regimen. HPV antibody titers were assessed 1 month after dose 3 using a competitive Luminex immunoassay and summarized...... as geometric mean titers (GMTs). Covariates examined were age, gender, race, region of residence, and HPV serostatus and PCR status at day 1. RESULTS: GMTs to all 9 vaccine HPV types decreased with age at vaccination initiation, and were otherwise generally similar among the demographic subgroups defined...

SPIRIT: A seamless phase I/II randomized design for immunotherapy trials.

Science.gov (United States)

Guo, Beibei; Li, Daniel; Yuan, Ying

2018-06-07

Immunotherapy-treatments that enlist the immune system to battle tumors-has received widespread attention in cancer research. Due to its unique features and mechanisms for treating cancer, immunotherapy requires novel clinical trial designs. We propose a Bayesian seamless phase I/II randomized design for immunotherapy trials (SPIRIT) to find the optimal biological dose (OBD) defined in terms of the restricted mean survival time. We jointly model progression-free survival and the immune response. Progression-free survival is used as the primary endpoint to determine the OBD, and the immune response is used as an ancillary endpoint to quickly screen out futile doses. Toxicity is monitored throughout the trial. The design consists of two seamlessly connected stages. The first stage identifies a set of safe doses. The second stage adaptively randomizes patients to the safe doses identified and uses their progression-free survival and immune response to find the OBD. The simulation study shows that the SPIRIT has desirable operating characteristics and outperforms the conventional design. Copyright © 2018 John Wiley & Sons, Ltd.

Direct Power Control for Three-Phase Two-Level Voltage-Source Rectifiers Based on Extended-State Observation

DEFF Research Database (Denmark)

Song, Zhanfeng; Tian, Yanjun; Yan, Zhuo

2016-01-01

This paper proposed a direct power control strategy for three-phase two-level voltage-source rectifiers based on extended-state observation. Active and reactive powers are directly regulated in the stationary reference frame. Similar to the family of predictive controllers whose inherent characte......This paper proposed a direct power control strategy for three-phase two-level voltage-source rectifiers based on extended-state observation. Active and reactive powers are directly regulated in the stationary reference frame. Similar to the family of predictive controllers whose inherent...

VIPR III VADR SPIDER Structural Design and Analysis

Science.gov (United States)

Li, Wesley; Chen, Tony

2016-01-01

In support of the National Aeronautics and Space Administration (NASA) Vehicle Integrated Propulsion Research (VIPR) Phase III team to evaluate the volcanic ash environment effects on the Pratt & Whitney F117-PW-100 turbofan engine, NASA Armstrong Flight Research Center has successfully performed structural design and analysis on the Volcanic Ash Distribution Rig (VADR) and the Structural Particulate Integration Device for Engine Research (SPIDER) for the ash ingestion test. Static and dynamic load analyses were performed to ensure no structural failure would occur during the test. Modal analysis was conducted, and the results were used to develop engine power setting avoidance zones. These engine power setting avoidance zones were defined to minimize the dwell time when the natural frequencies of the VADR/SPIDER system coincided with the excitation frequencies of the engine which was operating at various revolutions per minute. Vortex-induced vibration due to engine suction air flow during the ingestion test was also evaluated, but was not a concern.

Transient evaluation using EMTP at one phase opening with the offsite power transformer for the emergency power supply systems of nuclear power plants. This report is a follow-up of the report published two years ago. Verification related to the open-phase detection method of the transformer by United States Electric Power Research Institute (EPRI)

International Nuclear Information System (INIS)

Shimada, Yoshio

2015-01-01

The emergency power supply systems of nuclear power plants, as the objects of this research, are critical in supplying stable electric power to such systems as the emergency core cooling system (ECCS), and in maintaining safety of the nuclear power reactor; this was apparent in the accident at the Fukushima Daiichi Nuclear Power Station. The USNRC issued regulatory documents (BL 2012-01, IN 2012-03), and has commenced evaluations on newly emerged vulnerability in the design of power supply systems which cannot be detected with degraded-voltage protection relays, with certain kinds of configuration of coils and iron core structures, such as when the offsite power supply side is a wye-connection and the load side is a delta-connection etc., when the detection of one-phase open fault with the circuit of a transformer which is without a ground fault connected to the offsite power supply system. The report in the INSS JOURNAL 2013 used simulation by the electro-magnetic transients program (EMTP) and clearly described the response at the time of the power supply side one-phase open without ground fault for various configuration of coils and various iron core structures of the three-phase transformer, and identified the important issues in the response of emergency power supply systems and the safety related components of representative domestic PWR plants when the one-phase open fault occurred without ground fault. The report in the INSS JOURNAL 2014 summarizes the previous results, and then presents the principles by which normal voltages are maintained in both the primary and the secondary sides when the one-phase open failure without ground fault occurs on the primary side of the transformer, and the results of the simulations of operations of the protection relays of the emergency power supply systems and the safety related components of representative a domestic PWR plant with EMTP. In a continuation of the previous reports, this report explains the method to detect

Study Protocol: Phase III single-blinded fast-track pragmatic randomised controlled trial of a complex intervention for breathlessness in advanced disease

Directory of Open Access Journals (Sweden)

Brafman-Kennedy Barbara

2011-05-01

Full Text Available Abstract Background Breathlessness in advanced disease causes significant distress to patients and carers and presents management challenges to health care professionals. The Breathlessness Intervention Service (BIS seeks to improve the care of breathless patients with advanced disease (regardless of cause through the use of evidence-based practice and working with other healthcare providers. BIS delivers a complex intervention (of non-pharmacological and pharmacological treatments via a multi-professional team. BIS is being continuously developed and its impact evaluated using the MRC's framework for complex interventions (PreClinical, Phase I and Phase II completed. This paper presents the protocol for Phase III. Methods/Design Phase III comprises a pragmatic, fast-track, single-blind randomised controlled trial of BIS versus standard care. Due to differing disease trajectories, the service uses two broad service models: one for patients with malignant disease (intervention delivered over two weeks and one for patients with non-malignant disease (intervention delivered over four weeks. The Phase III trial therefore consists of two sub-protocols: one for patients with malignant conditions (four week protocol and one for patients with non-malignant conditions (eight week protocol. Mixed method interviews are conducted with patients and their lay carers at three to five measurement points depending on randomisation and sub-protocol. Qualitative interviews are conducted with referring and non-referring health care professionals (malignant disease protocol only. The primary outcome measure is 'patient distress due to breathlessness' measured on a numerical rating scale (0-10. The trial includes economic evaluation. Analysis will be on an intention to treat basis. Discussion This is the first evaluation of a breathlessness intervention for advanced disease to have followed the MRC framework and one of the first palliative care trials to use fast

Transient evaluation using EMTP at one phase opening of the offsite power transformer of the emergency power supply systems for nuclear power plants. This report is a follow-up the last year's

International Nuclear Information System (INIS)

Shimada, Yoshio

2014-01-01

The emergency power supply systems of nuclear power plants, as the objects of this research, are critical to supplying stable electric power to such systems as the emergency core cooling system (ECCS), and to maintaining the safety of the nuclear power reactor; this was apparent from the accident at the Fukushima Daiichi Nuclear Power Station. The USNRC issued regulatory documents (BL 2012-01, IN 2012-03), and has commenced to review those problems which cannot be detected by degraded-voltage protection relays such as new design vulnerability of the power supply systems that are certain kinds of winding structures and iron core structures when the one-phase open fault occurs without a ground fault of the transformer connected to the offsite power supply system, including when the offsite power supply side is a wye connection and the load side is a delta connection etc. The report of the INSS JOURNAL 2013 used simulation by the electro-magnetic transients program (EMTP) and obtained findings that clearly specified the response at the time of the power supply side one-phase open without ground fault of various winding structures and various iron core structures of the three-phase transformer and identified the important issues for the response of emergency power supply systems and the safety related components of representative domestic PWR plants when the one-phase open fault occurred without ground fault. In a continuation of the previous report, this paper summarizes the previous results, and then presents the principles by which normal voltages are maintained by both the primary and the secondary sides when the one-phase open failure without ground fault occurs on the primary side of the transformer, and the results of the analysis of operations of the protection relays of the emergency power systems and the safety related components of representative a domestic PWR plant by the simulation using EMTP. (author)

Power Factor Correction Capacitors for Multiple Parallel Three-Phase ASD Systems

DEFF Research Database (Denmark)

Yang, Yongheng; Blaabjerg, Frede

2017-01-01

Today’s three-phase Adjustable Speed Drive (ASD) systems still employ Diode Rectifiers (DRs) and Silicon-Controlled Rectifiers (SCRs) as the front-end converters due to structural and control simplicity, small volume, low cost, and high reliability. However, the uncontrollable DRs and phase......-controllable SCRs bring side-effects by injecting high harmonics to the grid, which will degrade the system performance in terms of lowering the overall efficiency and overheating the system if remain uncontrolled or unattenuated. For multiple ASD systems, certain harmonics in the entire system can be mitigated...... the power factor, passive capacitors can be installed, which yet can trigger the system resonance. Hence, this paper analyzes the resonant issues in multiple ASD systems with power factor correction capacitors. Potential damping solutions are summarized. Simulations are carried out, while laboratory tests...

Thermal Management of Transient Power Spikes in Electronics - Phase Change Energy Storage or Copper Heat Sinks?

OpenAIRE

Krishnan, S.; Garimella, S V

2004-01-01

A transient thermal analysis is performed to investigate thermal control of power semiconductors using phase change materials, and to compare the performance of this approach to that of copper heat sinks. Both the melting of the phase change material under a transient power spike input, as well as the resolidification process, are considered. Phase change materials of different kinds (paraffin waxes and metallic alloys) are considered, with and without the use of thermal conductivity enhancer...

Three-phase receiving coil of wireless power transmission system for gastrointestinal robot

Science.gov (United States)

Jia, Z. W.; Jiang, T.; Liu, Y.

2017-11-01

Power shortage is the bottleneck for the wide application of gastrointestinal (GI) robot. Owing to the limited volume and free change of orientation of the receiving set in GI trace, the optimal of receiving set is the key point to promote the transmission efficiency of wireless power transmission system. A new type of receiving set, similar to the winding of three-phase asynchronous motor, is presented and compared with the original three-dimensional orthogonal coil. Considering the given volume and the space utilization ratio, the three-phase and the three-orthogonal ones are the parameters which are optimized and compared. Both the transmission efficiency and stability are analyzed and verified by in vitro experiments. Animal experiments show that the new one could provide at least 420 mW power in volume of Φ11 × 13mm with a uniformity of 78.3% for the GI robot.

High-pressure single-crystal elasticity study of CO{sub 2} across phase I-III transition

Energy Technology Data Exchange (ETDEWEB)

Zhang, Jin S., E-mail: zhang72@illinois.edu; Bass, Jay D. [Department of Geology, University of Illinois, Urbana-Champaign, Illinois 61801 (United States); Shieh, Sean R. [Departments of Earth Sciences and Physics and Astronomy, University of Western Ontario, London, Ontario N6A 5B7 (Canada); Dera, Przemyslaw [Hawaii Institute of Geophysics and Planetology, University of Hawaii at Manoa, Honolulu, Hawaii 96822 (United States); Prakapenka, Vitali [Center for Advanced Radiation Sources, University of Chicago, Chicago, Illinois 60637 (United States)

2014-04-07

Sound velocities and elastic moduli of solid single-crystal CO{sub 2} were measured at pressures up to 11.7(3) GPa by Brillouin spectroscopy. The aggregate adiabatic bulk modulus (K{sub S}), shear modulus (G), and their pressure derivatives for CO{sub 2} Phase I are K{sub S0} = 3.4(6) GPa, G{sub 0} = 1.8(2) GPa, (dK{sub S}/dP){sub 0} = 7.8(3), (dG/dP){sub 0} = 2.5(1), (d{sup 2}K{sub S}/dP{sup 2}){sub 0} = −0.23(3) GPa{sup −1}, and (d{sup 2}G/dP{sup 2}){sub 0} = −0.10(1) GPa{sup −1}. A small increase of elastic properties was observed between 9.8(1) and 10.5(3) GPa, in agreement with the CO{sub 2} I-III transition pressure determined from previous x-ray diffraction experiments. Above the transition pressure P{sub T}, we observed a mixture dominated by CO{sub 2}-I, with minor CO{sub 2}-III. The CO{sub 2}-I + III mixture shows slightly increased sound velocities compared to pure CO{sub 2}-I. Elastic anisotropy calculated from the single-crystal elasticity tensor exhibits a decrease with pressure beginning at 7.9(1) GPa, which is lower than P{sub T}. Our results coincide with recent X-ray Raman observations, suggesting that a pressure-induced electronic transition is related to local structural and optical changes.

Direct vector controlled six-phase asymmetrical induction motor with power balanced space vector PWM multilevel operation

DEFF Research Database (Denmark)

Padmanaban, Sanjeevi Kumar; Grandi, Gabriele; Ojo, Joseph Olorunfemi

2016-01-01

In this paper, a six-phase (asymmetrical) machine is investigated, 300 phase displacement is set between two three-phase stator windings keeping deliberately in open-end configuration. Power supply consists of four classical three-phase voltage inverters (VSIs), each one connected to the open......-winding terminals. An original synchronous field oriented control (FOC) algorithm with three variables as degree of freedom is proposed, allowing power sharing among the four VSIs in symmetric/asymmetric conditions. A standard three-level space vector pulse width modulation (SVPWM) by nearest three vector (NTV......) approach was adopted for each couple of VSIs to operate as multilevel output voltage generators. The proposed power sharing algorithm is verified for the ac drive system by observing the dynamic behaviours in different set conditions by complete simulation modelling in software (Matlab...

Liquid-liquid extraction of ruthenium(III) thiocyanate with hexamethylphosphoramide: direct spectrophotometric determination in the organic phase

International Nuclear Information System (INIS)

Mitra, B.K.; Pal, B.K.; Chowdhury, R.P.

1982-01-01

Ru(III) thiocyanate has been extracted with hexamethylphosphoramide(HMPA) in methyl isobutyl ketone (MIBK). Thus the extractability, sensitivity and selectivity are improved over the simple binary Ru(III) thiocyanate system in spectrophotometric determination of ruthenium in the organic phase. The maximum colour develops on the steam bath, at the acidity range of 1.5 - 2.5 M with HCl and ammonium thiocyanate concentration range of 0.25 - O.5 M. The colour is completely extractable in MIBK when 1.5 - 3.0 ml HMPA is used and show maximum absorbance at 570 nm. The colour system obeys Beer's law for 0.7 - 13 μg Ru/ml and the optimum concentration range is 2 - 13 μg/ml. The molar absorptivity and sensitivity are 6940 l . mole -1 cm -1 and 0.0145 μg/cm 2 respectively. The percent relative error is 2.72%. The method is very simple and does not require oxidation and subsequent distillation. The method can be applied in the presence of osmium. (Author)

Runaway electron damage to the Tore Supra Phase III outboard pump limiter

International Nuclear Information System (INIS)

Nygren, R.; Lutz, T.; Walsh, D.; Martin, G.; Chatelier, M.; Loarer, T.; Guilhem, D.

1996-01-01

Operation of the Phase III outboard pump limiter (OPL) in Tore Supra in 1994 was terminated prematurely when runaway electrons during the current decay following a disruption pierced leading edge tube on the electron side and caused a water leak. The location, about 20 mm outside the last closed flux surface during normal operation, and the infrared (IR) images of the limiter indicate that the runaways moved in large outward steps, i.e. tens of millimeters, in one toroidal revolution. For plasma (runaway) currents in the range of 155 to 250 kA, the drift orbits open to the outside. Basic trajectory computations suggest that such motion is possible under the conditions present for this experiment. Activation measurements made on sections of the tube to indicate the area of local damage are presented here. An understanding of this event may provide important guidance regarding the potential damage from runaways in future tokamaks

Extraction of lanthanide(III) nitrates from water-salt solutions with n.-octanol

International Nuclear Information System (INIS)

Keskinov, V.A.; Kudrova, A.V.; Valueva, O.V.; Pyartman, A.K.

2004-01-01

Extraction of lanthanide(III) nitrates (Ln=La-Nd, Sm-Gd) from aqueous-salt solutions at 298.15 K was studied using solution of n.-octanol, its concentration 6.31 mol/l. It was ascertained that at Ln(NO 3 ) 3 concentration in aqueous phase below 0.6 mol/l, there is actually no extraction. At higher concentrations of nitrates in aqueous phase the content of lanthanides(III) in organic phase increases in the series La-Gd. Isotherms of extraction were ascertained, its phase equilibria being described mathematically. It is shown that extraction of lanthanide(III) nitrates with n.-octanol should be realized from concentrated aqueous solutions [ru

The Phase I/II BNCT Trials at the Brookhaven medical research reactor: Critical considerations

International Nuclear Information System (INIS)

Diaz, A.Z.

2001-01-01

A phase I/II clinical trial of boronophenylalanine-fructose (BPA-F) mediated boron neutron capture therapy (BNCT) for Glioblastoma Multiforme (GBM) was initiated at Brookhaven National Laboratory (BNL) in 1994. Many critical issues were considered during the design of the first of many sequential dose escalation protocols. These critical issues included patient selection criteria, boron delivery agent, dose limits to the normal brain, dose escalation schemes for both neutron exposure and boron dose, and fractionation. As the clinical protocols progressed and evaluation of the tolerance of the central nervous system (CNS) to BPA-mediated BNCT at the BMRR continued new specifications were adopted. Clinical data reflecting the progression of the protocols will be presented to illustrate the steps taken and the reasons behind their adoption. (author)

300C/15 kW power converter with AlGaN/GaN-Si MOS-HFETs for electric propulsion systems, Phase II

Data.gov (United States)

National Aeronautics and Space Administration — Capitalizing on a strong expertise in III-Nitride epitaxy, GaN-Si power device designs, and wide-bandgap power electronics, researchers at GeneSiC Semiconductor...

Code of Conduct for wind-power projects - Phases 1 and 2

International Nuclear Information System (INIS)

Strub, P.; Ziegler, Ch.

2008-08-01

This paper discusses the results of the first two phases of a project concerning wind-power projects. The paper deals with the results of a system analysis, takes a look at lessons learned and presents an appraisal of existing instruments. A system-analysis of wind-power projects is presented with emphasis on social factors and the role of stakeholders. The success factors concerning social acceptance of wind-power projects and their special characteristics are discussed. Lessons learned are examined. Instruments for the sustainable implementation of projects are looked at, in particular with a focus on social acceptance

A three-phase to three-phase series-resonant power converter with optimal input current waveforms, Part II: implementation and results

NARCIS (Netherlands)

Huisman, H.

1988-01-01

For pt.I see ibid., vol.35, no.2, p.263-8 (1988). A 15 kW three-phase prototype series-resonant power converter is constructed. The converter features sinusoidal output voltage and sinusoidal input currents. The control concepts and necessary electronics, as well as the layout of the power circuit,

Improved Design Methods for Robust Single- and Three-Phase ac-dc-ac Power Converters

DEFF Research Database (Denmark)

Qin, Zian

. The approaches for improving their performance, in terms of the voltage stress, efficiency, power density, cost, loss distribution, and temperature, will be studied. The structure of the thesis is as follows, Chapter 1 presents the introduction and motivation of the whole project as well as the background...... becomes a emerging challenge. Accordingly, installation of sustainable power generators like wind turbines and solar panels has experienced a large increase during the last decades. Meanwhile, power electronics converters, as interfaces in electrical system, are delivering approximately 80 % electricity...... back-to-back, and meanwhile improve the harmonics, control flexibility, and thermal distribution between the switches. Afterwards, active power decoupling methods for single-phase inverters or rectifiers that are similar to the single-phase ac-dc-ac converter, are studied in Chapter 4...

Phase II Results of RTOG 0537: A Phase II/III Study Comparing Acupuncture-like Transcutaneous Electrical Nerve Stimulation Versus Pilocarpine in Treating Early Radiation-Induced Xerostomia

Science.gov (United States)

Wong, Raimond K. W.; James, Jennifer L.; Sagar, Stephen; Wyatt, Gwen; Nguyen-Tân, Phuc Felix; Singh, Anurag K.; Lukaszczyk, Barbara; Cardinale, Francis; Yeh, Alexander M.; Berk, Lawrence

2011-01-01

Purpose This phase II component of a multi-institutional phase II/III randomized trial assessed the feasibility and preliminary efficacy of acupuncture-like transcutaneous electrical nerve stimulation (ALTENS) in reducing radiation-induced xerostomia. Methods Head and neck cancer patients who were 3–24 months from completing radiotherapy ± chemotherapy (RT±C) and experiencing xerostomia symptoms with basal whole saliva production ≥0.1 ml/min and without recurrence were eligible. Patients received twice weekly ALTENS sessions (24 over 12 weeks) using a Codetron™ unit. The primary objective assessed the feasibility of ALTENS treatment. A patient was considered compliant if 19/24 ALTENS were delivered, with a targeted 85% compliance rate. Secondary objectives measured treatment-related toxicities and ALTENS effect on overall radiation-induced xerostomia burden using the University of Michigan Xerostomia-Related Quality of Life Scale (XeQOLS). Results Of 48 accrued patients, 47 were evaluable. Median age was 60 years; 84% were male, 70% completed RT±C for > 12 months and 21% had received prior pilocarpine. All ALTENS sessions were completed in 34 patients, but 9 and 1 completed 20–23 and 19 sessions respectively, representing a 94% total compliance rate. 6-month XeQOLS scores were available for 35 patients; 30 (86%) achieved a positive treatment response with a mean reduction of 35.9% (SD 36.1). Five patients developed grade 1–2 gastrointestinal toxicity and one had grade 1 pain event. Conclusions ALTENS treatment for radiation-induced xerostomia can be uniformly delivered in a cooperative multicenter setting and has possible beneficial treatment response. Given these results, the phase III component of this study was initiated. PMID:22252927

Study on the extraction characteristics of Fe(III) with trialkylphosphine oxide

International Nuclear Information System (INIS)

Zhang Qiwei; Jiao Rongzhou; Song Chongli

1994-08-01

The extractive properties of TRPO (trialkyephosphine oxide) as the extractant for the Fe(III) have been studied. Under this experiment condition, the distribution ratio D of Fe (III) with the changes of extraction equilibrium time, temperature, nitric acid concentration and Fe 3+ concentration in aqueous solution have been determined. The ΔH degree, ΔS degree and apparent equilibrium constant K of the reaction in which Fe (III) is extracted by TRPO have been calculated. The experiment results show that the third phase appearance in 30% TRPO extractive system has close relations with Fe 3+ concentration in aqueous solution. When nitric acid concentration is 1.5 mol/L and Fe 3+ initial concentration is higher than 8.0 g/L in aqueous solution, the extractant system appears third phase. Two organic phase volume ratio and Fe(III) concentration ratio in the organic phases have been determined respectively, and they vary with the Fe 3+ concentration in aqueous solution

The Combination Process for Preparative Separation and Purification of Paclitaxel and 10-Deacetylbaccatin III Using Diaion® Hp-20 Followed by Hydrophilic Interaction Based Solid Phase Extraction.

Science.gov (United States)

Shirshekanb, Mahsa; Rezadoost, Hassan; Javanbakht, Mehran; Ghassempour, Ali Reza

2017-01-01

There is no other naturally occurring defense agent against cancer that has a stronger effect than paclitaxel, commonly known under the brand name of Taxol ® . The major drawback for the more widespread use of paclitaxel and its precious precursor, 10-deacetylbaccatin III (10-DAB III), is that they require large-scale extraction from different parts of yew trees ( Taxus species), cell cultures, taxane-producing endophytic fungi, and Corylus species. In our previous work, a novel online two-dimensional heart-cut liquid chromatography process using hydrophilic interaction/ reversed-phase chromatography was used to introduce a semi-preparative treatment for the separation of polar (10-deacetylbaccatin III) and non-polar (paclitaxel) taxanes from Taxus baccata L. In this work, a combination of the absorbent (Diaion ®  HP-20) and a silica based solid phase extraction is utilized as a new, efficient, and cost effective method for large-scale production of taxanes. This process avoids the technical problem of two-dimensional preparative liquid chromatography. The first stage of the process involves discarding co-extractive polar compounds including chlorophylls and pigments using a non-polar synthetic hydrophobic absorbent, Diaion ®  HP-20. Extract was then loaded on to a silica based hydrophilic interaction solid phase extraction (silica 40-60 micron). Taxanes was eluted using a mixture of water and methanol at the optimized ratio of 70:30. Finally, the fraction containing taxanes was applied to semi-preparative reversed phase HPLC. The results revealed that using this procedure, paclitaxel and 10-DAB III could be obtained at 8 and 3 times more, respectively than by the traditional method of extraction.

The Combination Process for Preparative Separation and Purification of Paclitaxel and 10-Deacetylbaccatin III Using Diaion® Hp-20 Followed by Hydrophilic Interaction Based Solid Phase Extraction

Science.gov (United States)

Shirshekanb, Mahsa; Rezadoost, Hassan; Javanbakht, Mehran; Ghassempour, Ali Reza

2017-01-01

There is no other naturally occurring defense agent against cancer that has a stronger effect than paclitaxel, commonly known under the brand name of Taxol®. The major drawback for the more widespread use of paclitaxel and its precious precursor, 10-deacetylbaccatin III (10-DAB III), is that they require large-scale extraction from different parts of yew trees (Taxus species), cell cultures, taxane-producing endophytic fungi, and Corylus species. In our previous work, a novel online two-dimensional heart-cut liquid chromatography process using hydrophilic interaction/ reversed-phase chromatography was used to introduce a semi-preparative treatment for the separation of polar (10-deacetylbaccatin III) and non-polar (paclitaxel) taxanes from Taxus baccata L. In this work, a combination of the absorbent (Diaion® HP-20) and a silica based solid phase extraction is utilized as a new, efficient, and cost effective method for large-scale production of taxanes. This process avoids the technical problem of two-dimensional preparative liquid chromatography. The first stage of the process involves discarding co-extractive polar compounds including chlorophylls and pigments using a non-polar synthetic hydrophobic absorbent, Diaion® HP-20. Extract was then loaded on to a silica based hydrophilic interaction solid phase extraction (silica 40-60 micron). Taxanes was eluted using a mixture of water and methanol at the optimized ratio of 70:30. Finally, the fraction containing taxanes was applied to semi-preparative reversed phase HPLC. The results revealed that using this procedure, paclitaxel and 10-DAB III could be obtained at 8 and 3 times more, respectively than by the traditional method of extraction. PMID:29552048

Adjuvant whole abdominal intensity modulated radiotherapy (IMRT) for high risk stage FIGO III patients with ovarian cancer (OVAR-IMRT-01) – Pilot trial of a phase I/II study: study protocol

International Nuclear Information System (INIS)

Rochet, Nathalie; Jensen, Alexandra D; Sterzing, Florian; Munter, Marc W; Eichbaum, Michael H; Schneeweiss, Andreas; Sohn, Christof; Debus, Juergen; Harms, Wolfgang

2007-01-01

The prognosis for patients with advanced epithelial ovarian cancer remains poor despite aggressive surgical resection and platinum-based chemotherapy. More than 60% of patients will develop recurrent disease, principally intraperitoneal, and die within 5 years. The use of whole abdominal irradiation (WAI) as consolidation therapy would appear to be a logical strategy given its ability to sterilize small tumour volumes. Despite the clinically proven efficacy of whole abdominal irradiation, the use of radiotherapy in ovarian cancer has profoundly decreased mainly due to high treatment-related toxicity. Modern intensity-modulated radiation therapy (IMRT) could allow to spare kidneys, liver, and bone marrow while still adequately covering the peritoneal cavity with a homogenous dose. The OVAR-IMRT-01 study is a single center pilot trial of a phase I/II study. Patients with advanced ovarian cancer stage FIGO III (R1 or R2< 1 cm) after surgical resection and platinum-based chemotherapy will be treated with whole abdomen irradiation as consolidation therapy using intensity modulated radiation therapy (IMRT) to a total dose of 30 Gy in 1.5 Gy fractions. A total of 8 patients will be included in this trial. For treatment planning bone marrow, kidneys, liver, spinal cord, vertebral bodies and pelvic bones are defined as organs at risk. The planning target volume includes the entire peritoneal cavity plus pelvic and para-aortic node regions. The primary endpoint of the study is the evaluation of the feasibility of intensity-modulated WAI and the evaluation of the study protocol. Secondary endpoint is evaluation of the toxicity of intensity modulated WAI before continuing with the phase I/II study. The aim is to explore the potential of IMRT as a new method for WAI to decrease the dose to kidneys, liver, bone marrow while covering the peritoneal cavity with a homogenous dose, and to implement whole abdominal intensity-modulated radiotherapy into the adjuvant multimodal

PBFA [Particle Beam Fusion Accelerator] II: The pulsed power characterization phase

International Nuclear Information System (INIS)

Martin, T.H.; Turman, B.N.; Goldstein, S.A.

1987-01-01

The Particle Beam Fusion Accelerator II, PBFA II, is now the largest pulsed power device in operation. This paper summarizes its first year and a half of operation for the Department of Energy (DOE) Inertial Confinement Fusion (ICF) program. Thirty-six separate modules provide 72 output pulses that combine to form a 100 TW output pulse at the accelerator center. PBFA II was successfully test fired for the first time on December 11, 1985. This test completed the construction phase (Phase 1) within the expected schedule and budget. The accelerator checkout phase then started (Phase 2). The first priority during checkout was to bring the Phase 1 subsystems into full operation. The accelerator was first tested to determine overall system performance. Next, subsystems that were not performing adequately were modified. The accelerator is now being used for ion diode studies. 32 refs

ESTABLISHED MODES AND STATIC CHARACTERISTICS OF THREE-PHASE ASYNCHRONOUS MOTOR POWERED WITH SINGLE PHASE NETWORK

Directory of Open Access Journals (Sweden)

V. S. Malyar

2016-01-01

Full Text Available A mathematical model is developed to study the operation of three-phase asynchronous motor with squirrel-cage rotor when the stator winding is powered from a single phase network. To create a rotating magnetic field one of the phases is fed through the capacitor. Due to the asymmetry of power feed not only transients, but the steady-state regimes are dynamic, so they are described by differential equations in any coordinate system. Their study cannot be carried out with sufficient adequacy on the basis of known equivalent circuits and require the use of dynamic parameters. In the mathematical model the state equations of the circuits of the stator and rotor are composed in the stationary three phase coordinate system. Calculation of the established mode is performed by solving the boundary problem that makes it possible to obtain the coordinate dependences over the period, without calculation of the transient process. In order to perform it, the original nonlinear differential equations are algebraized by approximating the variables with the use of cubic splines. The resulting nonlinear system of algebraic equations is a discrete analogue of the initial system of differential equations. It is solved by parameter continuation method. To calculate the static characteristics as a function of a certain variable, the system is analytically differentiated, and then numerically integrated over this variable. In the process of integration, Newton's refinement is performed at each step or at every few steps, making it possible to implement the integration in just a few steps using Euler's method. Jacobi matrices in both cases are the same. To account for the current displacement in the rods of the squirrel-cage rotor, each of them, along with the squirrel-cage rings, is divided in height into several elements. This results in several squirrel-cage rotor windings which are represented by three-phase windings with magnetic coupling between them.

Power-Quality-Oriented Optimization in Multiple Three-Phase Adjustable Speed Drives

DEFF Research Database (Denmark)

Yang, Yongheng; Davari, Pooya; Blaabjerg, Frede

2016-01-01

As an almost standardized configuration, Diode Rectifiers (DRs) and Silicon-Controlled Rectifiers (SCRs) are commonly employed as the front-end topology in three-phase Adjustable Speed Drive (ASD) systems. Features of this ASD configuration include: structural and control simplicity, small volume......, low cost, and high reliability during operation. Yet, DRs and SCRs bring harmonic distortions in the mains and thus lowering the overall efficiency. Power quality standards/rules are thus released. For multiple ASD systems, certain harmonics of the total grid current can be mitigated by phase......-shifting the currents drawn by SCR-fed drives, and thus it is much flexible to reduce the Total Harmonic Distortion (THD) level in such applications. However, the effectiveness of this harmonic mitigation scheme for multiple ASD systems depends on: a) the number of parallel drives, b) the power levels, and c...

Single Phase Passive Rectification Versus Active Rectification Applied to High Power Stirling Engines

Science.gov (United States)

Santiago, Walter; Birchenough, Arthur G.

2006-01-01

Stirling engine converters are being considered as potential candidates for high power energy conversion systems required by future NASA explorations missions. These types of engines typically contain two major moving parts, the displacer and the piston, in which a linear alternator is attached to the piston to produce a single phase sinusoidal waveform at a specific electric frequency. Since all Stirling engines perform at low electrical frequencies (less or equal to 100 Hz), space explorations missions that will employ these engines will be required to use DC power management and distribution (PMAD) system instead of an AC PMAD system to save on space and weight. Therefore, to supply such DC power an AC to DC converter is connected to the Stirling engine. There are two types of AC to DC converters that can be employed, a passive full bridge diode rectifier and an active switching full bridge rectifier. Due to the inherent line inductance of the Stirling Engine-Linear Alternator (SE-LA), their sinusoidal voltage and current will be phase shifted producing a power factor below 1. In order to keep power the factor close to unity, both AC to DC converters topologies will implement power factor correction. This paper discusses these power factor correction methods as well as their impact on overall mass for exploration applications. Simulation results on both AC to DC converters topologies with power factor correction as a function of output power and SE-LA line inductance impedance are presented and compared.

Intracranial electroencephalography power and phase synchronization changes during monaural and binaural beat stimulation.

Science.gov (United States)

Becher, Ann-Katrin; Höhne, Marlene; Axmacher, Nikolai; Chaieb, Leila; Elger, Christian E; Fell, Juergen

2015-01-01

Auditory stimulation with monaural or binaural auditory beats (i.e. sine waves with nearby frequencies presented either to both ears or to each ear separately) represents a non-invasive approach to influence electrical brain activity. It is still unclear exactly which brain sites are affected by beat stimulation. In particular, an impact of beat stimulation on mediotemporal brain areas could possibly provide new options for memory enhancement or seizure control. Therefore, we examined how electroencephalography (EEG) power and phase synchronization are modulated by auditory stimulation with beat frequencies corresponding to dominant EEG rhythms based on intracranial recordings in presurgical epilepsy patients. Monaural and binaural beat stimuli with beat frequencies of 5, 10, 40 and 80 Hz and non-superposed control signals were administered with low amplitudes (60 dB SPL) and for short durations (5 s). EEG power was intracranially recorded from mediotemporal, temporo-basal and temporo-lateral and surface sites. Evoked and total EEG power and phase synchronization during beat vs. control stimulation were compared by the use of Bonferroni-corrected non-parametric label-permutation tests. We found that power and phase synchronization were significantly modulated by beat stimulation not only at temporo-basal, temporo-lateral and surface sites, but also at mediotemporal sites. Generally, more significant decreases than increases were observed. The most prominent power increases were seen after stimulation with monaural 40-Hz beats. The most pronounced power and synchronization decreases resulted from stimulation with monaural 5-Hz and binaural 80-Hz beats. Our results suggest that beat stimulation offers a non-invasive approach for the modulation of intracranial EEG characteristics. © 2014 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

Complexation of trivalent actinides and lanthanides with hydrophilic N-donor ligands for Am(III)/Cm(III) and An(III)/Ln(III) separation; Komplexierung von trivalenten Actiniden und Lanthaniden mit hydrophilen N-Donorliganden zur Am(III)/Cm(III)- bzw. An(III)/Ln(III)-Trennung

Energy Technology Data Exchange (ETDEWEB)

Wagner, Christoph

2017-07-24

The implementation of actinide recycling processes is considered in several countries, aiming at the reduction of long-term radiotoxicity and heat load of used nuclear fuel. This requires the separation of the actinides from the fission and corrosion products. The separation of the trivalent actinides (An(III)) Am(III) and Cm(III), however, is complicated by the presence of the chemically similar fission lanthanides (Ln(III)). Hydrophilic N-donor ligands are employed as An(III) or Am(III) selective complexing agents in solvent extraction to strip An(III) or Am(III) from an organic phase loaded with An(III) and Ln(III). Though they exhibit excellent selectivity, the complexation chemistry of these ligands and the complexes formed during solvent extraction are not sufficiently characterized. In the present thesis the complexation of An(III) and Ln(III) with hydrophilic N-donor ligands is studied by time resolved laser fluorescence spectroscopy (TRLFS), UV/Vis, vibronic sideband spectroscopy and solvent extraction. TRLFS studies on the complexation of Cm(III) and Eu(III) with the Am(III) selective complexing agent SO{sub 3}-Ph-BTBP (tetrasodium 3,3{sup '},3'',3{sup '''}-([2,2{sup '}-bipyridine]-6,6{sup '}-diylbis(1,2,4-triazine-3,5,6-triyl)) tetrabenzenesulfonate) revealed the formation of [M(SO{sub 3}-Ph-BTBP){sub n}]{sup (4n-3)-} complexes (M = Cm(III), Eu(III); n = 1, 2). The conditional stability constants were determined in different media yielding two orders of magnitude larger β{sub 2}-values for the Cm(III) complexes, independently from the applied medium. A strong impact of ionic strength on the stability and stoichiometry of the formed complexes was identified, resulting from the stabilization of the pentaanionic [M(SO{sub 3}-Ph-BTBP){sub 2}]{sup 5-} complex with increasing ionic strength. Thermodynamic studies of Cm(III)-SO{sub 3}-Ph-BTBP complexation showed that the proton concentration of the applied medium impacts

Rituximab Maintenance Treatment of Relapsed/Resistant Follicular Non-Hodgkin's Lymphoma: Long-Term Outcome of the EORTC 20981 Phase III Randomized Intergroup Study

NARCIS (Netherlands)

van Oers, Marinus H. J.; van Glabbeke, Martine; Giurgea, Livia; Klasa, Richard; Marcus, Robert E.; Wolf, Max; Kimby, Eva; van 't Veer, Mars; Vranovsky, Andrej; Holte, Harald; Hagenbeek, Anton

2010-01-01

Purpose In 2006, we published the results of the European Organisation for Research and Treatment of Cancer phase III trial EORTC 20981 on the role of rituximab in remission induction and maintenance treatment of relapsed/resistant follicular lymphoma (FL). At that time, the median follow-up for the

Subtask 2.18 - Advancing CO₂ Capture Technology: Partnership for CO₂ Capture (PCO₂C) Phase III

Energy Technology Data Exchange (ETDEWEB)

Kay, John; Azenkeng, Alexander; Fiala, Nathan; Jensen, Melanie; Laumb, Jason; Leroux, Kerryanne; McCollor, Donald; Stanislowski, Joshua; Tolbert, Scott; Curran, Tyler

2016-03-31

Industries and utilities continue to investigate ways to decrease their carbon footprint. Carbon capture and storage (CCS) can enable existing power generation facilities to meet the current national CO₂ reduction goals. The Partnership for CO2 Capture Phase III focused on several important research areas in an effort to find ways to decrease the cost of capture across both precombustion and postcombustion platforms. Two flue gas pretreatment technologies for postcombustion capture, an SO₂ reduction scrubbing technology from Cansolv Technologies Inc. and the Tri-Mer filtration technology that combines particulate, NOx, and SO₂ control, were evaluated on the Energy & Environmental Research Center’s (EERC’s) pilot-scale test system. Pretreating the flue gas should enable more efficient, and therefore less expensive, CO₂ capture. Both technologies were found to be effective in pretreating flue gas prior to CO₂ capture. Two new postcombustion capture solvents were tested, one from the Korea Carbon Capture and Sequestration R&D Center (KCRC) and one from CO₂ Solutions Incorporated. Both of these solvents showed the ability to capture CO₂ while requiring less regeneration energy, which would reduce the cost of capture. Hydrogen separation membranes from Commonwealth Scientific and Industrial Research Organisation were evaluated through precombustion testing. They are composed of vanadium alloy, which is less expensive than the palladium alloys that are typically used. Their performance was comparable to that of other membranes that have been tested at the EERC. Aspen Plus® software was used to model the KCRC and CO₂ Solutions solvents and found that they would result in significantly improved overall plant performance. The modeling effort also showed that the parasitic steam load at partial capture of 45% is less than half that of 90% overall capture, indicating savings that

Implementation of Four-Phase Interleaved Balance Charger for Series-Connected Batteries with Power Factor Correction

Science.gov (United States)

Juan, Y. L.; Lee, Y. T.; Lee, Y. L.; Chen, L. L.; Huang, M. L.

2017-11-01

A four-phase interleaved balance charger for series-connected batteries with power factor correction is proposed in this dissertation. In the two phases of two buckboost converters, the rectified ac power is firstly converted to a dc link capacitor. In the other two phases of two flyback converters, the rectified ac power is directly converted to charge the corresponding batteries. Additionally, the energy on the leakage inductance of flyback converter is bypassed to the dc link capacitor. Then, a dual-output balance charging circuit is connected to the dc link to deliver the dc link power to charge two batteries in the series-connected batteries module. The constant-current/constant-voltage charging strategy is adopted. Finally, a prototype of the proposed charger with rated power 500 W is constructed. From the experimental results, the performance and validity of the proposed topology are verified. Compared to the conventional topology with passive RCD snubber, the efficiency of the proposed topology is improved about 3% and the voltage spike on the active switch is also reduced. The efficiency of the proposed charger is at least 83.6 % within the CC/CV charging progress.

Coping with missing data in phase III pivotal registration trials: Tolvaptan in subjects with kidney disease, a case study.

Science.gov (United States)

Ouyang, John; Carroll, Kevin J; Koch, Gary; Li, Junfang

2017-07-01

Missing data cause challenging issues, particularly in phase III registration trials, as highlighted by the European Medicines Agency (EMA) and the US National Research Council. We explore, as a case study, how the issues from missing data were tackled in a double-blind phase III trial in subjects with autosomal dominant polycystic kidney disease. A total of 1445 subjects were randomized in a 2:1 ratio to receive active treatment (tolvaptan), or placebo. The primary outcome, the rate of change in total kidney volume, favored tolvaptan (P outline the analyses undertaken to address the issue of missing data thoroughly. "Tipping point analyses" were performed to explore how extreme and detrimental outcomes among subjects with missing data must be to overturn the positive treatment effect attained in those subjects who had complete data. Nonparametric rank-based analyses were also performed accounting for missing data. In conclusion, straightforward and transparent analyses directly taking into account missing data convincingly support the robustness of the preplanned analyses on the primary and secondary endpoints. Tolvaptan was confirmed to be effective in slowing total kidney volume growth, which is considered an efficacy endpoint by EMA, and in lessening the decline in renal function in patients with autosomal dominant polycystic kidney disease. Copyright © 2017 John Wiley & Sons, Ltd.

Effects of Mg/Ga and V/III source ratios on hole concentration of N-polar (000\\bar{1}) p-type GaN grown by metalorganic vapor phase epitaxy

Science.gov (United States)

Nonoda, Ryohei; Shojiki, Kanako; Tanikawa, Tomoyuki; Kuboya, Shigeyuki; Katayama, Ryuji; Matsuoka, Takashi

2016-05-01

The effects of growth conditions such as Mg/Ga and V/III ratios on the properties of N-polar (000\\bar{1}) p-type GaN grown by metalorganic vapor phase epitaxy were studied. Photoluminescence spectra from Mg-doped GaN depended on Mg/Ga and V/III ratios. For the lightly doped samples, the band-to-acceptor emission was observed at 3.3 eV and its relative intensity decreased with increasing V/III ratio. For the heavily doped samples, the donor-acceptor pair emission was observed at 2.8 eV and its peak intensity monotonically decreased with V/III ratio. The hole concentration was maximum for the Mg/Ga ratio. This is the same tendency as in group-III polar (0001) growth. The V/III ratio also reduced the hole concentration. The higher V/III ratio reduced the concentration of residual donors such as oxygen by substituting nitrogen atoms. The surface became rougher with increasing V/III ratio and the hillock density increased.

New analogues of Cucurbita maxima trypsin inhibitor III (CMTI III) with simplified structure.

Science.gov (United States)

Rolka, K; Kupryszewski, G; Rózycki, J; Ragnarsson, U; Zbyryt, T; Otlewski, J

1992-10-01

Seven new analogues of trypsin inhibitor CMTI III were obtained by solid-phase peptide synthesis. Three analogues contained only two, instead of three, disulfide bridges, whereas the molecules of the next four analogues were shortened at the N- and/or C-terminus. The elimination of one disulfide bridge in CMTI III induces a decrease in the association equilibrium constants by 6-7 orders of magnitude, whereas the removal of one, two or three amino-acid residues at the N- and/or C-terminus does not significantly affect the activity.

Code of Conduct for wind-power projects - Phase 3; Code of Conduct fuer windkraftprojekte. Phase 3 Machbarkeit und Strategie

Energy Technology Data Exchange (ETDEWEB)

Strub, P. [Pierre Strub, freischaffender Berater, Binningen (Switzerland); Ziegler, Ch. [Inter Act, Basel (Switzerland)

2008-11-15

This paper discusses the results of phase three of a project concerning wind-power projects. Feasibility and strategy aspects are examined and discussed. The current state of the wind power market is discussed on the basis of the results of a survey made on the subject. The social acceptance of wind power installations is discussed, whereby the rejection of particular projects is compared with a general lack of acceptance. Requirements placed on such projects and possible solutions are discussed. Finally, the feasibility of setting up a code of conduct in the area of wind-power projects is discussed and the definition of further instruments is examined

Solid phase extraction of Am(III) and Cm(III) from acidic feeds using tetraethyl diglycolamide (TEDGA) in ionic liquid

NARCIS (Netherlands)

Gujar, R.B.; Ansari, S.A.; Mohapatra, P.K.; Leoncini, Andrea; Verboom, Willem

2016-01-01

Solvent extraction of Am(III) and Cm(III) with several diglycolamide ligands in an ionic liquid, [C4mim][Tf2N] was investigated from nitric acid medium. Based on the encouraging extraction behaviour with N,N,N′,N′-tetraethyldiglycolamide (TEDGA), extraction chromatographic studies were carried out

Microstructure of III-N semiconductors related to their applications in optoelectronics

Science.gov (United States)

Leszczynski, M.; Czernetzki, R.; Sarzynski, M.; Krysko, M.; Targowski, G.; Prystawko, P.; Bockowski, M.; Grzegory, I.; Suski, T.; Domagala, J.; Porowski, S.

2005-03-01

There has been more than a decade since Shuji Nakamura from Japanese company Nichia constructed the first blue LED based on structure of (AlGaIn)N semiconductor and eight years since he made the first blue laser diode (LD). This work gives a survey on the current technological status with green/blue/violet/UV optoelectronics based on III-N semiconductors in relation with their microstructure. The following devices are presented: i) Low-power green and blue LEDs, ii) High-power LEDs targeting solid-state white lighting, iii) Low-power violet LDs for high definition DVD market, iv) High-power violet LDs, v) UV LEDs. The discussion will be focused on three main technological problems related to the microstructure of (AlGaIn)N layers in emitters based on III-N semiconductors: i) high density of dislocations in epitaxial layers of GaN on foreign substrates (sapphire, SiC, GaAs), ii), presence of strains, iii) atom segregation in ternary and quaternary compounds.

Development of a DC-DC conversion powering scheme for the CMS Phase-1 pixel upgrade

CERN Document Server

Feld, Lutz Werner; Karpinski, Waclaw; Klein, Katja; Lipinski, Martin; Preuten, Marius; Max Rauch; Rittich, David Michael; Sammet, Jan Domenik; Wlochal, Michael

2014-01-01

A novel powering scheme based on the DC-DC conversion technique will be exploited to power the CMS Phase-1 pixel detector. DC-DC buck converters for the CMS pixel project have been developed, based on the AMIS5 ASIC designed by CERN. The powering system of the Phase-1 pixel detector is described and the performance of the converter prototypes is detailed, including power efficiency, stability of the output voltage, shielding, and thermal management. Results from a test of the magnetic field tolerance of the DC-DC converters are reported. System tests with pixel modules using many components of the future pixel barrel system are summarized. Finally first impressions from a pre-series of 200 DC-DC converters are presented.

A portable solar-powered air-cooling system based on phase-change materials for a vehicle cabin

International Nuclear Information System (INIS)

Qi, Lingfei; Pan, Hongye; Zhu, Xin; Zhang, Xingtian; Salman, Waleed; Zhang, Zutao; Li, Li; Zhu, Miankuan; Yuan, Yanping; Xiang, Bo

2017-01-01

Graphical abstract: This paper proposed a portable solar-powered air cooling system for a vehicle cabin based on Phase-change Materials. The cooling system contains three main parts: a solar-energy collection module, an energy-storage module and a phase-change cooling module. The operating principle can be described as follows. For energy input, the solar-energy-collection module harvests solar energy and converts it to electricity. The power-storage module stores the electrical energy in the supercapacitor to power the electrical equipment, mainly the air pump (AP) and water pump (WP) of the phase-change cooling module. Finally, the phase-change cooling module provides cold air for the vehicle cabin to create a comfortable vehicle interior in a hot summer. The proposed system is demonstrated through thermal simulations, which show the long-duration cooling effect of the system. Temperature drops of were obtained in field tests, predicting that the proposed cooling system is beneficial and practical for cooling vehicle cabins. - Highlights: • A novel portable air cooling system based on PCMs is presented. • Solar energy was adopted to power the proposed air cooling system. • This proposed system is used for cooling vehicle cabins exposed to the sun. • Experimental results show that the proposed system has a good cooling effect. - Abstract: In summer, the temperature is very high inside vehicles parked under the hot sun. This causes consuming more fossil energy to power the air conditioner and generation of harmful gases. There is currently no effective method to address this problem in an energy-saving and environmentally friendly manner. In this paper, a novel solar-powered air-cooling system for vehicle cabins is proposed based on Phase-change Materials (PCMs); the system prevents the temperature inside a vehicle cabin from rising too high when the vehicle is parked outdoor exposure to the sun. The proposed system consists of three main parts: a solar

The Design of a High Speed Low Power Phase Locked Loop

CERN Document Server

Liu, Tiankuan; Hou, Suen; Liang, Zhihua; Liu, Chonghan; Su, Da-Shung; Teng, Ping-Kun; Xiang, Annie C; Ye, Jingbo

2009-01-01

The upgrade of the ATLAS Liquid Argon Calorimeter readout system calls for the development of radiation tolerant, high speed and low power serializer ASIC. We have designed a phase locked loop using a commercial 0.25-μm Silicon-on- Sapphire (SoS) CMOS technology. Post-layout simulation indicates that tuning range is 3.79 – 5.01 GHz and power consumption is 104 mW. The PLL has been submitted for fabrication. The design and simulation results are presented.

Integrated safety analysis of rolapitant with coadministered drugs from phase II/III trials

DEFF Research Database (Denmark)

Barbour, S; Smit, T.; Wang, X

2017-01-01

adverse events by use versus non-use of drug substrates of CYP2D6 or BCRP. Patients and methods: Patients were randomized to receive either 180 mg oral rolapitant or placebo approximately 1-2 hours before chemotherapy in combination with a 5-hydroxytryptamine type 3 RA and dexamethasone. Data...... cytochrome P450 (CYP) 3A4, but it does inhibit CYP2D6 and breast cancer resistance protein (BCRP). To analyze potential drug-drug interactions between rolapitant and concomitant medications, this integrated safety analysis of four double-blind, randomized phase II or III studies of rolapitant examined...... for treatment-emergent adverse events (TEAEs) and treatment-emergent serious adverse events (TESAEs) during cycle 1 were pooled across the four studies and summarized in the overall population and by concomitant use/non-use of CYP2D6 or BCRP substrate drugs. Results: In the integrated safety population, 828...

Power loads in the limiter phase of Wendelstein 7-X

Energy Technology Data Exchange (ETDEWEB)

Niemann, Holger; Jakubowski, Marcin; Sunn Pedersen, Thomas [Max-Planck-Institut fuer Plasmaphysik, Greifswald (Germany); Wurden, Glen [Los Alamos National Laboratory, Los Alamos (United States)

2016-07-01

Wendelstein 7-X (W7-X), an advanced stellarator with five-fold symmetry, will start its initial plasma operation phase(OP1.1) in December 2015. In OP1.1 the plasma-wall interaction is realized with 5 graphite limiters installed on the inboard side of the plasma vessel, which should efficiently intercept >99% of the convective plasma heat load at the plasma edge with the chosen magnetic configuration. Assuming an even distribution of power loads among all 5 limiters, discharges with 2 MW of ECRH heating power could be run for up to a second. Calculations shows typical three separate helical magnetic flux bundles of different connection length in the order of a few tens of meters. These form 3-D structure of magnetic footprints results in localized peaks in the limiter power deposition patterns. The heterogenous temperature distribution pattern will be investigated with two IR cameras. The heat flux density will be evaluated with the THEODOR code from evolution of the surface temperature data. Together with two sets of Langmuir probes in module 5 this provides enough data to resolve experimentally different channels of heat transport towards the limiter in OP1.1 plasmas. Additionally, the obtained data will be compared against the output of EMC3-Eirene calculations to identify the channels of energy transport at the plasma boundary in the first operation phase of W7-X.

Uptake Of Trivalent Actinides (Cm(III)) And Lanthanides (Eu(III)) By Cement-Type Minerals: A Wet Chemistry And Time-Resolved Laser Fluorescence Spectroscopy (TRLFS) Study

Energy Technology Data Exchange (ETDEWEB)

Tits, J.; Stumpf, T; Wieland, E.; Fanghaenel, T

2003-03-01

The interaction of the two chemical homologues Cm (III) and Eu(III) with calcium silicate hydrates at pH 13.3 has been investigated in batch-type sorption studies using Eu(III), and complemented with time-resolved laser fluorescence spectroscopy using Cm(III). The sorption data for Eu(III) reveal fast sorption kinetics, and a strong uptake by CSH phases, with distribution ratios of 6({+-}3)*105 L kg-1. Three different types of sorbed Cm(III) species have been identified: a non-fluorescing species, which was identified as Cm cluster present either as surface precipitate or as Cm(III) colloid in solution, and two sorbed fluorescing species. The sorbed fluorescing species have characteristic emission spectra (main peak maxima at 618.9 nm and 620.9 nm) and fluorescence emission lifetimes (289 {+-} 11 ms and 1482{+-} 200 ms). From the fluorescence lifetimes, it appears that the two fluorescing Cm(III) species have, respectively, one to two or no water molecules left in their first coordination sphere, suggesting that these species are incorporated into the CSH structure. A structural model for Cm(III) and Eu(III) incorporation into CSH phases is proposed based on the substitution of Ca at two different types of sites in the CSH structure. (author)

Should positive phase III clinical trial data be required before proton beam therapy is more widely adopted? No

International Nuclear Information System (INIS)

Suit, Herman; Kooy, Hanne; Trofimov, Alexei; Farr, Jonathan; Munzenrider, John; DeLaney, Thomas; Loeffler, Jay; Clasie, Benjamin; Safai, Sairos; Paganetti, Harald

2008-01-01

Purpose: Evaluate the rationale for the proposals that prior to a wider use of proton radiation therapy there must be supporting data from phase III clinical trials. That is, would less dose to normal tissues be an advantage to the patient? Methods: Assess the basis for the assertion that proton dose distributions are superior to those of photons for most situations. Consider the requirements for determining the risks of normal tissue injury, acute and remote, in the examination of the data from a trial. Analyze the probable cost differential between high technology photon and proton therapy. Evaluate the rationale for phase III clinical trials of proton vs photon radiation therapy when the only difference in dose delivered is a difference in distribution of low LET radiation. Results: The distributions of biological effective dose by protons are superior to those by X-rays for most clinical situations, viz. for a defined dose and dose distribution to the target by protons there is a lower dose to non-target tissues. This superiority is due to these physical properties of protons: (1) protons have a finite range and that range is exclusively dependent on the initial energy and the density distribution along the beam path; (2) the Bragg peak; (3) the proton energy distribution may be designed to provide a spread out Bragg peak that yields a uniform dose across the target volume and virtually zero dose deep to the target. Importantly, proton and photon treatment plans can employ beams in the same number and directions (coplanar, non-co-planar), utilize intensity modulation and employ 4D image guided techniques. Thus, the only difference between protons and photons is the distribution of biologically effective dose and this difference can be readily evaluated and quantified. Additionally, this dose distribution advantage should increase the tolerance of certain chemotherapeutic agents and thus permit higher drug doses. The cost of service (not developmental) proton

Structural systematics of rare earth complexes. III. Structural characterization of lanthanoid (III) picrate hydrates: gadolinium picrate dodecahydrate - an x-ray-induced phase modifications? - and some general aspects of structural chemistry of lanthanoid picrates

International Nuclear Information System (INIS)

Harrowfield, J.M.; Weimin, Lu; Brian, W.S.; White, A.H.

1994-01-01

In the course of the previous studies (Parts I and II), an unusual result was observed in the case of the structure determination of hydrated gadolinium(III) picrate. Midway through data collection, the monoclinic P2 1 /c phase modification (X-ray-induced?) to a similar cell more nearly resembling that of the La→Pr structure type recorded previously, with no loss of crystal integrity, and with useful data sets being obtained on both forms. Redetermination of the structure with a fresh sample yielded no reproduction of the anomaly. These results are recorded and discussed, together with an overview of the consequences of the data of Parts I-III in relation to those of other literature in the field. 13 refs., 4 tabs., 1 fig

Three-phase multilevel inverter configuration for open-winding high power application

DEFF Research Database (Denmark)

Sanjeevikumar, Padmanaban; Blaabjerg, Frede; Wheeler, Patrick William

2015-01-01

This paper work exploits a new dual open-winding three-phase multilevel inverter configuration suitable for high power medium-voltage applications. Modular structure comprised of standard three-phase voltage source inverter (VSI) along with one additional bi-directional semiconductor device (MOSFET...... for implementation purpose. Proposed dual-inverter configuration generates multilevel outputs with benefit includes reduced THD and dv/dt in comparison to other dual-inverter topologies. Complete model of the multilevel ac drive is developed with simple MSCFM modulation in Matlab/PLECs numerical software...

Structure in the 3D Galaxy Distribution. III. Fourier Transforming the Universe: Phase and Power Spectra

Energy Technology Data Exchange (ETDEWEB)

Scargle, Jeffrey D.; Way, M. J.; Gazis, P. R., E-mail: Jeffrey.D.Scargle@nasa.gov, E-mail: Michael.J.Way@nasa.gov, E-mail: PGazis@sbcglobal.net [NASA Ames Research Center, Astrobiology and Space Science Division, Moffett Field, CA 94035 (United States)

2017-04-10

We demonstrate the effectiveness of a relatively straightforward analysis of the complex 3D Fourier transform of galaxy coordinates derived from redshift surveys. Numerical demonstrations of this approach are carried out on a volume-limited sample of the Sloan Digital Sky Survey redshift survey. The direct unbinned transform yields a complex 3D data cube quite similar to that from the Fast Fourier Transform of finely binned galaxy positions. In both cases, deconvolution of the sampling window function yields estimates of the true transform. Simple power spectrum estimates from these transforms are roughly consistent with those using more elaborate methods. The complex Fourier transform characterizes spatial distributional properties beyond the power spectrum in a manner different from (and we argue is more easily interpreted than) the conventional multipoint hierarchy. We identify some threads of modern large-scale inference methodology that will presumably yield detections in new wider and deeper surveys.

Structure in the 3D Galaxy Distribution. III. Fourier Transforming the Universe: Phase and Power Spectra

International Nuclear Information System (INIS)

Scargle, Jeffrey D.; Way, M. J.; Gazis, P. R.

2017-01-01

We demonstrate the effectiveness of a relatively straightforward analysis of the complex 3D Fourier transform of galaxy coordinates derived from redshift surveys. Numerical demonstrations of this approach are carried out on a volume-limited sample of the Sloan Digital Sky Survey redshift survey. The direct unbinned transform yields a complex 3D data cube quite similar to that from the Fast Fourier Transform of finely binned galaxy positions. In both cases, deconvolution of the sampling window function yields estimates of the true transform. Simple power spectrum estimates from these transforms are roughly consistent with those using more elaborate methods. The complex Fourier transform characterizes spatial distributional properties beyond the power spectrum in a manner different from (and we argue is more easily interpreted than) the conventional multipoint hierarchy. We identify some threads of modern large-scale inference methodology that will presumably yield detections in new wider and deeper surveys.

PV Power-Generation System with a Phase-Shift PWM Technique for High Step-Up Voltage Applications

Directory of Open Access Journals (Sweden)

Cheng-Tao Tsai

2012-01-01

Full Text Available A PV power-generation system with a phase-shift pulse-width modulation (PWM technique for high step-up voltage applications is proposed. The proposed power-generation system consists of two stages. In the input stage, all power switches of the full-bridge converter with phase-shift technique can be operated with zero-current switching (ZCS at turn-on or turn-off transition. Hence, the switching losses of the power switches can be reduced. Then, in the DC output stage, a voltage-doubler circuit is used to boost a high dc-link bus voltage. To supply a utility power, a dc/ac inverter is connected to induce a sinusoidal source. In order to draw a maximum power from PV arrays source, a microcontroller is incorporated with the perturbation and observation method to implement maximum power point tracking (MPPT algorithm and power regulating scheme. In this study, a full load power of 300 W prototype has been built. Experimental results are presented to verify the performance and feasibility of the proposed PV power-generation system.

High-Efficiency, Nanowire Based Thermoelectric Devices for Radioisotope Power Conversion, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — This SBIR Phase I proposal responds to topic S3.03 of the 2010 NASA SBIR solicitation, for Power Generation and Conversion. Thermoelectric devices offer a simple and...

A quality assurance audit: phase III trial of maximal androgen deprivation in prostate cancer (TROG 96.01).

Science.gov (United States)

Steigler, A; Mameghan, H; Lamb, D; Joseph, D; Matthews, J; Franklin, I; Turner, S; Spry, N; Poulsen, M; North, J; Kovacev, O; Denham, J

2000-02-01

In 1997 the Trans-Tasman Radiation Oncology Group (TROG) performed a quality assurance (QA) audit of its phase III randomized clinical trial investigating the effectiveness of different durations of maximal androgen deprivation prior to and during definitive radiation therapy for locally advanced carcinoma of the prostate (TROG 96.01). The audit reviewed a total of 60 cases from 15 centres across Australia and New Zealand. In addition to verification of technical adherence to the protocol, the audit also incorporated a survey of centre planning techniques and a QA time/cost analysis. The present report builds on TROG's first technical audit conducted in 1996 for the phase III accelerated head and neck trial (TROG 91.01) and highlights the significant progress TROG has made in the interim period. The audit provides a strong validation of the results of the 96.01 trial, as well as valuable budgeting and treatment planning information for future trials. Overall improvements were detected in data quality and quantity, and in protocol compliance, with a reduction in the rate of unacceptable protocol violations from 10 to 4%. Audit design, staff education and increased data management resources were identified as the main contributing factors to these improvements. In addition, a budget estimate of $100 per patient has been proposed for conducting similar technical audits. The next major QA project to be undertaken by TROG during the period 1998-1999 is an intercentre dosimetry study. Trial funding and staff education have been targeted as the key major issues essential to the continued success and expansion of TROG's QA programme.

Position-controlled epitaxial III-V nanowires on silicon

NARCIS (Netherlands)

Roest, A.L.; Verheijen, M.A.; Wunnicke, O.; Serafin, S.N.; Wondergem, H.J.; Bakkers, E.P.A.M.

2006-01-01

We show the epitaxial integration of III-V semiconductor nanowires with silicon technology. The wires are grown by the VLS mechanism with laser ablation as well as metal-organic vapour phase epitaxy. The hetero-epitaxial growth of the III-V nanowires on silicon was confirmed with x-ray diffraction

Growth, structure and phase transitions of epitaxial nanowires of III-V semiconductors

International Nuclear Information System (INIS)

Glas, F; Patriarche, G; Harmand, J C

2010-01-01

We review and illustrate the impact of TEM on the study of nanowires of non-nitride III-V semiconductors, with particular emphasis on the understanding of the thermodynamics and kinetics of their formation assisted by nano-sized catalyst particles. Besides providing basic information about the morphology of the nanowires and their growth rate as a function of diameter, TEM offers insights into the peculiar crystalline structure that they adopt. We discuss the formation of the unusual wurtzite hexagonal crystalline phase and that of planar stacking defects in these nanowires and show that they are kinetically controlled. We also demonstrate the transformation of wurtzite into cubic sphalerite upon epitaxial burying of the nanowires. Nanowires are particularly interesting in that they allow the fabrication of precisely positioned quantum dots with well-defined geometries. In this respect, we discuss the formation of strained quantum-size inclusions in nanowires, their critical dimensions and the kinetic and thermodynamic factors governing the changes of the crystalline structure that sometimes occur around a hetero-interface.

Impact of Dengue Vaccination on Serological Diagnosis: Insights From Phase III Dengue Vaccine Efficacy Trials.

Science.gov (United States)

Plennevaux, Eric; Moureau, Annick; Arredondo-García, José L; Villar, Luis; Pitisuttithum, Punnee; Tran, Ngoc H; Bonaparte, Matthew; Chansinghakul, Danaya; Coronel, Diana L; L'Azou, Maïna; Ochiai, R Leon; Toh, Myew-Ling; Noriega, Fernando; Bouckenooghe, Alain

2018-04-03

We previously reported that vaccination with the tetravalent dengue vaccine (CYD-TDV; Dengvaxia) may bias the diagnosis of dengue based on immunoglobulin M (IgM) and immunoglobulin G (IgG) assessments. We undertook a post hoc pooled analysis of febrile episodes that occurred during the active surveillance phase (the 25 months after the first study injection) of 2 pivotal phase III, placebo-controlled CYD-TDV efficacy studies that involved ≥31000 children aged 2-16 years across 10 countries in Asia and Latin America. Virologically confirmed dengue (VCD) episode was defined with a positive test for dengue nonstructural protein 1 antigen or dengue polymerase chain reaction. Probable dengue episode was serologically defined as (1) IgM-positive acute- or convalescent-phase sample, or (2) IgG-positive acute-phase sample and ≥4-fold IgG increase between acute- and convalescent-phase samples. There were 1284 VCD episodes (575 and 709 in the CYD-TDV and placebo groups, respectively) and 17673 other febrile episodes (11668 and 6005, respectively). Compared with VCD, the sensitivity and specificity of probable dengue definition were 93.1% and 77.2%, respectively. Overall positive and negative predictive values were 22.9% and 99.5%, respectively, reflecting the much lower probability of correctly confirming probable dengue in a population including a vaccinated cohort. Vaccination-induced bias toward false-positive diagnosis was more pronounced among individuals seronegative at baseline. Caution will be required when interpreting IgM and IgG data obtained during routine surveillance in those vaccinated with CYD-TDV. There is an urgent need for new practical, dengue-specific diagnostic algorithms now that CYD-TDV is approved in a number of dengue-endemic countries. NCT01373281 and NCT01374516.

Portable Thermoelectric Power Generator Coupled with Phase Change Material

OpenAIRE

Lim Chong C.; Al-Kayiem Hussain H.; Sing Chin Y.

2014-01-01

Solar is the intermittent source of renewable energy and all thermal solar systems having a setback on non-functioning during the night and cloudy environment. This paper presents alternative solution for power generation using thermoelectric which is the direct conversion of temperature gradient of hot side and cold side of thermoelectric material to electric voltage. Phase change material with latent heat effect would help to prolong the temperature gradient across thermoelectric material f...

Experience from design, prototyping and production of a DC–DC conversion powering scheme for the CMS Phase-1 Pixel Upgrade

Energy Technology Data Exchange (ETDEWEB)

Feld, Lutz, E-mail: Lutz.Feld@cern.ch; Karpinski, Waclaw; Klein, Katja; Lipinski, Martin; Preuten, Marius; Rauch, Max; Schmitz, Stefan; Wlochal, Michael

2017-02-11

The CMS pixel detector will be replaced during the technical stop 2016/2017. To allow the new pixel detector to be powered with the legacy cable plant and power supplies, a novel powering scheme based on DC–DC conversion will be employed. After the successful conclusion of an extensive development and prototyping phase, mass production of 1800 DC–DC converters as well as motherboards and other power PCBs has now been completed. This contribution reviews the lessons learned from the development of the power system for the Phase-1 pixel detector, and summarizes the experience gained from the production phase.

Cloud point extraction: an alternative to traditional liquid-liquid extraction for lanthanides(III) separation.

Science.gov (United States)

Favre-Réguillon, Alain; Draye, Micheline; Lebuzit, Gérard; Thomas, Sylvie; Foos, Jacques; Cote, Gérard; Guy, Alain

2004-06-17

Cloud point extraction (CPE) was used to extract and separate lanthanum(III) and gadolinium(III) nitrate from an aqueous solution. The methodology used is based on the formation of lanthanide(III)-8-hydroxyquinoline (8-HQ) complexes soluble in a micellar phase of non-ionic surfactant. The lanthanide(III) complexes are then extracted into the surfactant-rich phase at a temperature above the cloud point temperature (CPT). The structure of the non-ionic surfactant, and the chelating agent-metal molar ratio are identified as factors determining the extraction efficiency and selectivity. In an aqueous solution containing equimolar concentrations of La(III) and Gd(III), extraction efficiency for Gd(III) can reach 96% with a Gd(III)/La(III) selectivity higher than 30 using Triton X-114. Under those conditions, a Gd(III) decontamination factor of 50 is obtained.

Randomized phase III study comparing paclitaxel/cisplatin/gemcitabine and gemcitabine/cisplatin in patients with locally advanced or metastatic urothelial cancer without prior systemic therapy

DEFF Research Database (Denmark)

Bellmunt, Joaquim; von der Maase, Hans; Mead, Graham M

2012-01-01

The combination of gemcitabine plus cisplatin (GC) is a standard regimen in patients with locally advanced or metastatic urothelial cancer. A phase I/II study suggested that a three-drug regimen that included paclitaxel had greater antitumor activity and might improve survival....

Regularized lattice Boltzmann model for immiscible two-phase flows with power-law rheology

Science.gov (United States)

Ba, Yan; Wang, Ningning; Liu, Haihu; Li, Qiang; He, Guoqiang

2018-03-01

In this work, a regularized lattice Boltzmann color-gradient model is developed for the simulation of immiscible two-phase flows with power-law rheology. This model is as simple as the Bhatnagar-Gross-Krook (BGK) color-gradient model except that an additional regularization step is introduced prior to the collision step. In the regularization step, the pseudo-inverse method is adopted as an alternative solution for the nonequilibrium part of the total distribution function, and it can be easily extended to other discrete velocity models no matter whether a forcing term is considered or not. The obtained expressions for the nonequilibrium part are merely related to macroscopic variables and velocity gradients that can be evaluated locally. Several numerical examples, including the single-phase and two-phase layered power-law fluid flows between two parallel plates, and the droplet deformation and breakup in a simple shear flow, are conducted to test the capability and accuracy of the proposed color-gradient model. Results show that the present model is more stable and accurate than the BGK color-gradient model for power-law fluids with a wide range of power-law indices. Compared to its multiple-relaxation-time counterpart, the present model can increase the computing efficiency by around 15%, while keeping the same accuracy and stability. Also, the present model is found to be capable of reasonably predicting the critical capillary number of droplet breakup.

Industrial Implementation of Environmentally Friendly Nanometal Electroplating Process for Chromium and Copper Beryllium Replacement using Low Cost Pulse Current Power Supplies

Science.gov (United States)

2014-09-10

FINAL REPORT Industrial Implementation of Environmentally Friendly Nanometal Electroplating Process for Chromium and Copper Beryllium...35 3.2 Phase II – Development/Verification that Nanotechnology Based Electroplating Process to Replace EHC/Cu-Be Processes are Compatible With...36 3.3 Phase III – Development of 200kW Power Supply and Compatible Nanostructured Electroplating Processed for Commercialization

CMPO-calix[4]arenes and the influence of structural modifications on the Eu(III), Am(III), Cm(III) separation

International Nuclear Information System (INIS)

Peters, C.; Braekers, D.; Desreux, J.F.; Kasyan, O.; Miroshnichenko, S.; Rudzevich, V.; Boehmer, V.

2008-01-01

The syntheses of new calix[4]arenes featuring CMPO groups on the wide rim are reported and the extraction of Am(III) and Eu(III) from concentrated HNO 3 aqueous phases are discussed with reference to the properties of the symmetric tetra-CMPO derivative 1. All extraction studies were conducted in the same experimental conditions which allows to directly compare the dependence of the distribution coefficients of various calixarenes on the acid concentration (0.1 M 3 ] < 5 M). Calix[4]arene 1 becomes a very poor extractant if the length of the aliphatic chain between the amide and phosphine oxide groups of CMPO is increased, if the bridging methylene groups are replaced by sulfur atoms or if the macrocyclic cavity size is increased. By contrast, mixed amide - CMPO calix[4]arenes are nearly as effective than 1. Moreover, Am(III)/Cm(III) separation coefficients between 1.5 and 3 have been obtained with unsymmetrical calix[4]arenes of type 1 with different aliphatic chains grafted on the narrow rim. Guidelines to anticipate the extraction ability of calix[4]arenes remain elusive because of the intricate solution behavior of these compounds. (orig.)

Power production from biomass III. Gasification and pyrolysis R and D and D for industry

Energy Technology Data Exchange (ETDEWEB)

Sipilae, K.; Korhonen, M. [eds.] [VTT Energy, Espoo (Finland). New Energy Technologies

1999-07-01

The Seminar on Power Production from Biomass III. Gasification and Pyrolysis R and D and D for Industry, was held on 14-15 September 1998 in Espoo. The seminar was organised by VTT Energy in co-operation with the University of Groningen, EU-Thermie Programme and Technology Development Centre, Finland (Tekes). Overviews of current activities on power production from biomass and wastes in Europe and in the United States were given, and all European and U. S. demonstration projects on biomass gasification were presented. In Europe, the target is to produce additional 90 Mtoe/a of bioenergy for the market by 2010. This is a huge challenge for the bioenergy sector, including biomass production and harvesting, conversion technology, energy companies, and end users. In USA, U.S. Department of Energy is promoting the Biomass Power Programme to encourage and assist industry in the development and validation of renewable, biomass-based electricity generation systems, the objective being to double the present use of 7 000 MW biomass power by the year 2010. The new Finnish PROGAS Programme initiated by VTT was also introduced. Several gasification projects are today on the demonstration stage prior to entering the commercial level. Pyrolysis technologies are not yet on the demonstration stage on the energy market. Bio-oils can easily be transported, stored and utilised in existing boiler and diesel plants. The proceedings include the presentations given by the keynote speakers and other invited speakers, as well as some extended poster presentations. (orig.)

Oxidation of Cr(III)-Fe(III) Mixed-phase Hydroxides by Chlorine: Implications on the Control of Hexavalent Chromium in Drinking Water.

Science.gov (United States)

Chebeir, Michelle; Liu, Haizhou

2018-05-17

The occurrence of chromium (Cr) as an inorganic contaminant in drinking water is widely reported. One source of Cr is its accumulation in iron-containing corrosion scales of drinking water distribution systems as Cr(III)-Fe(III) hydroxide, i.e., FexCr(1-x)(OH)3(s), where x represents the Fe(III) molar content and typically varies between 0.25 and 0.75. This study investigated the kinetics of inadvertent hexavalent chromium Cr(VI) formation via the oxidation of FexCr(1-x)(OH)3(s) by chlorine as a residual disinfectant in drinking water, and examined the impacts of Fe(III) content and drinking water chemical parameters including pH, bromide and bicarbonate on the rate of Cr(VI) formation. Data showed that an increase in Fe(III) molar content resulted in a significant decrease in the stoichiometric Cr(VI) yield and the rate of Cr(VI) formation, mainly due to chlorine decay induced by Fe(III) surface sites. An increase in bicarbonate enhanced the rate of Cr(VI) formation, likely due to the formation of Fe(III)-carbonato surface complexes that slowed down the scavenging reaction with chlorine. The presence of bromide significantly accelerated the oxidation of FexCr(1-x)(OH)3(s) by chlorine, resulting from the catalytic effect of bromide acting as an electron shuttle. A higher solution pH between 6 and 8.5 slowed down the oxidation of Cr(III) by chlorine. These findings suggested that the oxidative conversion of chromium-containing iron corrosion products in drinking water distribution systems can lead to the occurrence of Cr(VI) at the tap, and the abundance of iron, and a careful control of pH, bicarbonate and bromide levels can assist the control of Cr(VI) formation.

Objective Lightning Probability Forecasting for Kennedy Space Center and Cape Canaveral Air Force Station, Phase III

Science.gov (United States)

Crawford, Winifred C.

2010-01-01

The AMU created new logistic regression equations in an effort to increase the skill of the Objective Lightning Forecast Tool developed in Phase II (Lambert 2007). One equation was created for each of five sub-seasons based on the daily lightning climatology instead of by month as was done in Phase II. The assumption was that these equations would capture the physical attributes that contribute to thunderstorm formation more so than monthly equations. However, the SS values in Section 5.3.2 showed that the Phase III equations had worse skill than the Phase II equations and, therefore, will not be transitioned into operations. The current Objective Lightning Forecast Tool developed in Phase II will continue to be used operationally in MIDDS. Three warm seasons were added to the Phase II dataset to increase the POR from 17 to 20 years (1989-2008), and data for October were included since the daily climatology showed lightning occurrence extending into that month. None of the three methods tested to determine the start of the subseason in each individual year were able to discern the start dates with consistent accuracy. Therefore, the start dates were determined by the daily climatology shown in Figure 10 and were the same in every year. The procedures used to create the predictors and develop the equations were identical to those in Phase II. The equations were made up of one to three predictors. TI and the flow regime probabilities were the top predictors followed by 1-day persistence, then VT and Ll. Each equation outperformed four other forecast methods by 7-57% using the verification dataset, but the new equations were outperformed by the Phase II equations in every sub-season. The reason for the degradation may be due to the fact that the same sub-season start dates were used in every year. It is likely there was overlap of sub-season days at the beginning and end of each defined sub-season in each individual year, which could very well affect equation

Targeting radioimmunotherapy of hepatocellular carcinoma with iodine (131I) metuximab injection: Clinical Phase I/II trials

International Nuclear Information System (INIS)

Chen Zhinan; Mi Li; Xu Jing

2006-01-01

Purpose: HAb18G/CD147 is a hepatocellular carcinoma (HCC)-associated antigen. We developed iodine ( 131 I) metuximab injection (Licartin), a novel 131 I-labeled HAb18G/CD147-specific monoclonal antibody F(ab') 2 fragment, and evaluated its safety, pharmacokinetics, and clinical efficacy on HCC in Phase I/II trials. Methods and Materials: In a Phase I trial, 28 patients were randomly assigned to receive the injection in 9.25-, 18.5-, 27.75-, or 37-MBq/kg doses by hepatic artery infusion. In a multicenter Phase II trial, 106 patients received the injection (27.75 MBq/kg) on Day 1 of a 28-day cycle. Response rate and survival rate were the endpoints. Results: No life-threatening toxic effects were found. The safe dosage was 27.75 MBq/kg. The blood clearance fitted a biphasic model, and its half-life was 90.56-63.93 h. In the Phase II trial, the injection was found to be targeted and concentrated to tumor tissues. Of the 73 patients completing two cycles, 6 (8.22%) had a partial response, 14 (19.18%) minor response, and 43 (58.90%) stable disease. The 21-month survival rate was 44.54%. The survival rate of progression-free patients was significantly higher than that of patients with progressive disease after either one or two cycles (p 131 I) metuximab injection is safe and active for HCC patients

Phase III trial of casopitant, a novel neurokinin-1 receptor antagonist, for the prevention of nausea and vomiting in patients receiving moderately emetogenic chemotherapy

DEFF Research Database (Denmark)

Herrstedt, Jørn; Apornwirat, Wichit; Shaharyar, Ahmed

2009-01-01

PURPOSE: The purpose of this phase III trial was to evaluate the efficacy and safety of regimens containing casopitant, a novel neurokinin-1 receptor antagonist, for the prevention of chemotherapy-induced nausea and vomiting during the first cycle in patients receiving moderately emetogenic chemo...

An integrative approach to the design methodology for 3-phase power conditioners in Photovoltaic Grid-Connected systems

International Nuclear Information System (INIS)

Rey-Boué, Alexis B.; García-Valverde, Rafael; Ruz-Vila, Francisco de A.; Torrelo-Ponce, José M.

2012-01-01

Highlights: ► A design methodology for Photovoltaic grid-connected systems is presented. ► Models of the Photovoltaic Generator and the 3-phase Inverter are described. ► The power factor and the power quality are regulated with vector control. ► Simulation and experimental results validate the design methodology. ► The proposed methodology can be extended to any Renewable or Industrial System. - Abstract: A novel methodology is presented in this paper, for the design of the Power and Control Subsystems of a 3-phase Photovoltaic Grid-Connected system in an easy and comprehensive way, as an integrative approach. At the DC side of the Power Subsystem, the Photovoltaic Generator modeling is revised and a simple model is proposed, whereas at the AC side, a vector analysis is done to deal with the instantaneous 3-phase variables of the grid-connected Voltage Source Inverter. A d–q control approach is established in the Control Subsystem, along with its specific tuned parameters, as a vector control alternative which will allow the decoupled control of the instantaneous active and reactive powers. A particular Case of Study is presented to illustrate the behavior of the design methodology regarding the fulfillment of the Photovoltaic plant specifications. Some simulations are run to study the performance of the Photovoltaic Generator together with the exerted d–q control to the grid-connected 3-phase inverter, and some experimental results, obtained from a built flexible platform, are also shown. The simulations and the experimental results validate the overall performance of the 3-phase Photovoltaic Grid-Connected system due to the attained unitary power factor operation together with good power quality. The final validation of the proposed design methodology is also achieved.

The future of nuclear power in France. An analysis of the costs of phasing-out

International Nuclear Information System (INIS)

Malischek, Raimund; Trueby, Johannes

2014-01-01

Nuclear power is an important pillar in electricity generation in France. However, France's nuclear power plant fleet is ageing, and the possibility of reducing its share in power generation or even a complete phaseout has been increasingly discussed. Our research therefore focuses on three questions: First, what are the costs of phasing-out nuclear power in France under different scenarios? Second, who has to bear these costs, i.e., how much of the costs will be passed on to the rest of the European power system? And third, what effect does the uncertainty regarding future nuclear policy in France have on system costs? Applying a stochastic optimization model for the European electricity system, we show that additional system costs in France of a nuclear phase-out amount up to 76 billion EURO 2010 . Additional costs are mostly borne by the French power system. Surprisingly, we find that the costs of uncertainty are rather limited. Based on our results, we conclude that a commitment regarding nuclear policy reform is only mildly beneficial in terms of system costs.

Power and phase monitoring system for the lower hybrid phased array heating system on ATC machine

International Nuclear Information System (INIS)

Reed, B.W.

1975-01-01

A four waveguide phased array slow wave structure has been constructed to couple microwave energy into plasma in the ATC Tokamac at Princeton. Theory has indicated that the coupling of power into the plasma column is a strong function of the imposed fourier spectrum at the antenna aperture. To optimize heating, and to verify theoretical results, a precision amplitude and phase monitoring system has been designed and constructed. The system data output is routed to an IBM 1800 computer where the fourier spectrum in n/sub parallel/ space is computed for discrete increments of time during an RF pulse. Computer output data is used to update the adjustment of transmission line parameters in between pulses

THREE-PHASE ENERGY SUPPLY SYSTEMS SIMULATION FOR THE TOTAL POWER LOSSES COMPONENTS ASSESSMENT

Directory of Open Access Journals (Sweden)

D.V. Tugay

2016-09-01

Full Text Available Purpose. The goal is to optimize a structure of Matlab-model of the three-phase energy supply system with power active filter. The mathematical model that describes the energy supply system modes of operation which contains additional losses is proposed. Methodology. We have applied concepts of the electrical circuits theory, mathematical modeling elements based on linear algebra and vector calculus, mathematical simulation in Matlab package. Results. We have developed two models of three-phase energy supply system. The first one is based on a vector representation, and the second one on the matrix representation of energy processes. Using these models we have solved the problem of maintaining unchanged the average useful power for 279 cases of energy supply system modes of operation. Originality. We have developed methods of mathematical analysis of a three-phase energy supply systems with polyharmonic voltages and currents in the symmetric and asymmetric modes. Practical value. We have created Matlab-model of a three-phase energy supply system with automated calculation of a correction factor. It allows reducing more than one order the time for energy processes elucidation in multiphase systems.

Phase III trial of high and low dose rate interstitial radiotherapy for early oral tongue cancer

International Nuclear Information System (INIS)

Inoue, Takehiro; Inoue, Toshihiko; Teshima, Teruki; Murayama, Shigeyuki; Shimizutani, Kimishige; Fuchihata, Hajime; Furukawa, Souhei

1996-01-01

Purpose: Oral tongue carcinomas are highly curable with radiotherapy. In the past, patients with tongue carcinoma have usually been treated with low dose rate (LDR) interstitial radiation. This Phase III study was designed to compare the treatment results obtained with LDR with those obtained with high dose rate (HDR) interstitial radiotherapy for tongue carcinoma. Methods and Materials: The criteria for patient selection for the Phase III study were: (a) presence of a T1T2N0 tumor that could be treated with single-plane implantation, (b) localization of tumor at the lateral tongue border, (c) tumor thickness of 10 mm or less, (d) performance status between O and 3, and (e) absence of any severe concurrent disease. From April 1992 through December 1993, 15 patients in the LDR group (70 Gy/4 to 9 days) and 14 patients in the HDR group (60 Gy/10 fractions/6 days) were accrued. The time interval between two fractions of the HDR brachytherapy was more than 6 h. Results: Local recurrence occurred in two patients treated with LDR brachytherapy but in none of the patients treated with HDR. One- and 2-year local control rates for patients in the LDR group were both 86%, compared with 100% in the HDR group (p = 0.157). There were four patients with nodal metastasis in the LDR group and three in the HDR group. Local recurrence occurred in two of the four patients with nodal metastases in the LDR group. One- and 2-year nodal control rates for patients in the LDR group are were 85%, compared with 79% in the HDR group. Conclusion: HDR fractionated interstitial brachytherapy can be an alternative to traditional LDR brachytherapy for early tongue cancer and eliminate the radiation exposure for medical staffs

PCM power - Final report; Power PCM - Rapport final

Energy Technology Data Exchange (ETDEWEB)

Citherlet, S.; Bony, J.; Morel, J.

2008-07-01

In a previous project (COSY-PCM) performed within Task 32 of the Solar Heating and Cooling Program of the International Energy Agency (IEA), we had analyzed the potential of energy storage by using phase-change materials (PCM) immersed in the tank of a combined solar heating system for space heating and domestic hot water. The potential of PCM use seemed to be highly dependent on the power of the equipment involved. If the power is too high the PCM is not able to store and to return the heat it should, due to the poor thermal conductivity of this type of material, even if a mixture of sodium acetate and graphite is used. The aim of the reported follow-up project was to develop nomographs for a fast and easy dimensioning of a water storage tank using phase-change materials (paraffin and sodium acetate with graphite) as a function of heat load, storage volume, and diameter of the PCM modules. For this purpose we have: (i) performed a measurement campaign on a new storage tank; (ii) developed a mathematical model of the installation under investigation, based upon the model previously developed for the description of the behaviour of the PCM; (iii) validated the model with experimental results; (iv) performed a series of simulations to create the nomographs. We have also studied the environmental impacts of sodium acetate. (author)

Passive Two-Phase Cooling of Automotive Power Electronics: Preprint

Energy Technology Data Exchange (ETDEWEB)

Moreno, G.; Jeffers, J. R.; Narumanchi, S.; Bennion, K.

2014-08-01

Experiments were conducted to evaluate the use of a passive two-phase cooling strategy as a means of cooling automotive power electronics. The proposed cooling approach utilizes an indirect cooling configuration to alleviate some reliability concerns and to allow the use of conventional power modules. An inverter-scale proof-of-concept cooling system was fabricated, and tests were conducted using the refrigerants hydrofluoroolefin HFO-1234yf and hydrofluorocarbon HFC-245fa. Results demonstrated that the system can dissipate at least 3.5 kW of heat with 250 cm3 of HFC-245fa. An advanced evaporator design that incorporates features to improve performance and reduce size was conceived. Simulation results indicate its thermal resistance can be 37% to 48% lower than automotive dual side cooled power modules. Tests were also conducted to measure the thermal performance of two air-cooled condensers--plain and rifled finned tube designs. The results combined with some analysis were then used to estimate the required condenser size per operating conditions and maximum allowable system (i.e., vapor and liquid) temperatures.

Obtaining valid laboratory data in clinical trials conducted in resource diverse settings: lessons learned from a microbicide phase III clinical trial.

Directory of Open Access Journals (Sweden)

Tania Crucitti

2010-10-01

Full Text Available Over the last decade several phase III microbicides trials have been conducted in developing countries. However, laboratories in resource constrained settings do not always have the experience, infrastructure, and the capacity to deliver laboratory data meeting the high standards of clinical trials. This paper describes the design and outcomes of a laboratory quality assurance program which was implemented during a phase III clinical trial evaluating the efficacy of the candidate microbicide Cellulose Sulfate 6% (CS [1].In order to assess the effectiveness of CS for HIV and STI prevention, a phase III clinical trial was conducted in 5 sites: 3 in Africa and 2 in India. The trial sponsor identified an International Central Reference Laboratory (ICRL, responsible for the design and management of a quality assurance program, which would guarantee the reliability of laboratory data. The ICRL provided advice on the tests, assessed local laboratories, organized trainings, conducted supervision visits, performed re-tests, and prepared control panels. Local laboratories were provided with control panels for HIV rapid tests and Chlamydia trachomatis/Neisseria gonorrhoeae (CT/NG amplification technique. Aliquots from respective control panels were tested by local laboratories and were compared with results obtained at the ICRL.Overall, good results were observed. However, discordances between the ICRL and site laboratories were identified for HIV and CT/NG results. One particular site experienced difficulties with HIV rapid testing shortly after study initiation. At all sites, DNA contamination was identified as a cause of invalid CT/NG results. Both problems were timely detected and solved. Through immediate feedback, guidance and repeated training of laboratory staff, additional inaccuracies were prevented.Quality control guidelines when applied in field laboratories ensured the reliability and validity of final study data. It is essential that sponsors

Pseudo Class III malocclusion

Directory of Open Access Journals (Sweden)

Fadia M. Al-Hummayani

2016-04-01

Full Text Available The treatment of deep anterior crossbite is technically challenging due to the difficulty of placing traditional brackets with fixed appliances. This case report represents a none traditional treatment modality to treat deep anterior crossbite in an adult pseudo class III malocclusion complicated by severely retruded, supraerupted upper and lower incisors. Treatment was carried out in 2 phases. Phase I treatment was performed by removable appliance “modified Hawley appliance with inverted labial bow,” some modifications were carried out to it to suit the presented case. Positive overbite and overjet was accomplished in one month, in this phase with minimal forces exerted on the lower incisors. Whereas, phase II treatment was performed with fixed appliances (braces to align teeth and have proper over bite and overjet and to close posterior open bite, this phase was accomplished within 11 month.

Reliability Evaluation of a Single-phase H-bridge Inverter with Integrated Active Power Decoupling

DEFF Research Database (Denmark)

Tang, Junchaojie; Wang, Haoran; Ma, Siyuan

2016-01-01

it with the traditional passive DC-link solution. The converter level reliability is obtained by component level electro-thermal stress modeling, lifetime model, Weibull distribution, and Reliability Block Diagram (RBD) method. The results are demonstrated by a 2 kW single-phase inverter application.......Various power decoupling methods have been proposed recently to replace the DC-link Electrolytic Capacitors (E-caps) in single-phase conversion system, in order to extend the lifetime and improve the reliability of the DC-link. However, it is still an open question whether the converter level...... reliability becomes better or not, since additional components are introduced and the loading of the existing components may be changed. This paper aims to study the converter level reliability of a single-phase full-bridge inverter with two kinds of active power decoupling module and to compare...

Bleeding and infection with external ventricular drainage: a systematic review in comparison with adjudicated adverse events in the ongoing Clot Lysis Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III (CLEAR-III IHV) trial.

Science.gov (United States)

Dey, Mahua; Stadnik, Agnieszka; Riad, Fady; Zhang, Lingjiao; McBee, Nichol; Kase, Carlos; Carhuapoma, J Ricardo; Ram, Malathi; Lane, Karen; Ostapkovich, Noeleen; Aldrich, Francois; Aldrich, Charlene; Jallo, Jack; Butcher, Ken; Snider, Ryan; Hanley, Daniel; Ziai, Wendy; Awad, Issam A

2015-03-01

Retrospective series report varied rates of bleeding and infection with external ventricular drainage (EVD). There have been no prospective studies of these risks with systematic surveillance, threshold definitions, or independent adjudication. To analyze the rate of complications in the ongoing Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III (CLEAR III) trial, providing a comparison with a systematic review of complications of EVD in the literature. Patients were prospectively enrolled in the CLEAR III trial after placement of an EVD for obstructive intraventricular hemorrhage and randomized to receive recombinant tissue-type plasminogen activator or placebo. We counted any detected new hemorrhage (catheter tract hemorrhage or any other distant hemorrhage) on computed tomography scan within 30 days from the randomization. Meta-analysis of published series of EVD placement was compiled with STATA software. Growing or unstable hemorrhage was reported as a cause of exclusion from the trial in 74 of 5707 cases (1.3%) screened for CLEAR III. The first 250 patients enrolled have completed adjudication of adverse events. Forty-two subjects (16.8%) experienced ≥1 new bleeds or expansions, and 6 of 250 subjects (2.4%) suffered symptomatic hemorrhages. Eleven cases (4.4%) had culture-proven bacterial meningitis or ventriculitis. Risks of bleeding and infection in the ongoing CLEAR III trial are comparable to those previously reported in EVD case series. In the present study, rates of new bleeds and bacterial meningitis/ventriculitis are very low despite multiple daily injections, blood in the ventricles, the use of thrombolysis in half the cases, and generalization to >60 trial sites.

Procedure Development and Qualification of the Phased Array Ultrasonic Testing for the Nuclear Power Plant Piping Weld

International Nuclear Information System (INIS)

Yoon, Byung Sik; Yang, Seung Han; Kim, Yong Sik; Lee, Hee Jong

2010-01-01

The manual ultrasonic examination for the nuclear power plant piping welds has been demonstrated by using KPD(Korean Performance Demonstration) generic procedure. For automated ultrasonic examination, there is no generic procedure and it should be qualified by using applicable automated equipment. Until now, most of qualified procedures used pulse-echo technique and there is no qualified procedure using phased array technique. In this study, data acquisition and analysis software were developed and phased-array transducer and wedge were designed to implement phased array technique for nuclear power plant in-service inspection. The developed procedure are qualified for performance demonstration for the flaw detection, length sizing and depth sizing. The qualified procedure will be applied for the field examination in the nuclear power plant piping weld inspection

Coherent beam combination using self-phase locked stimulated Brillouin scattering phase conjugate mirrors with a rotating wedge for high power laser generation.

Science.gov (United States)

Park, Sangwoo; Cha, Seongwoo; Oh, Jungsuk; Lee, Hwihyeong; Ahn, Heekyung; Churn, Kil Sung; Kong, Hong Jin

2016-04-18

The self-phase locking of a stimulated Brillouin scattering-phase conjugate mirror (SBS-PCM) allows a simple and scalable coherent beam combination of existing lasers. We propose a simple optical system composed of a rotating wedge and a concave mirror to overcome the power limit of the SBS-PCM. Its phase locking ability and the usefulness on the beam-combination laser are demonstrated experimentally. A four-beam combination is demonstrated using this SBS-PCM scheme. The relative phases between the beams were measured to be less than λ/24.7.

Trends in heteroepitaxy of III-Vs on silicon for photonic and photovoltaic applications

Science.gov (United States)

Lourdudoss, Sebastian; Junesand, Carl; Kataria, Himanshu; Metaferia, Wondwosen; Omanakuttan, Giriprasanth; Sun, Yan-Ting; Wang, Zhechao; Olsson, Fredrik

2017-02-01

We present and compare the existing methods of heteroepitaxy of III-Vs on silicon and their trends. We focus on the epitaxial lateral overgrowth (ELOG) method as a means of achieving good quality III-Vs on silicon. Initially conducted primarily by near-equilibrium epitaxial methods such as liquid phase epitaxy and hydride vapour phase epitaxy, nowadays ELOG is being carried out even by non-equilibrium methods such as metal organic vapour phase epitaxy. In the ELOG method, the intermediate defective seed and the mask layers still exist between the laterally grown purer III-V layer and silicon. In a modified ELOG method called corrugated epitaxial lateral overgrowth (CELOG) method, it is possible to obtain direct interface between the III-V layer and silicon. In this presentation we exemplify some recent results obtained by these techniques. We assess the potentials of these methods along with the other existing methods for realizing truly monolithic photonic integration on silicon and III-V/Si heterojunction solar cells.

A Phase I-II dose escalation study of fixed-dose rate gemcitabine, oxaliplatin and capecitabine every two weeks in advanced cholangiocarcinomas

DEFF Research Database (Denmark)

Lassen, Ulrik V; Jensen, Lars Henrik; Sorensen, Morten

2011-01-01

(O) and capecitabine (C), and evaluate the safety and efficacy of this regimen in patients with advanced cholangiocarcinoma (CC). Methods. In the Phase I part of the study a dose-escalation schedule of FDR G, O and C, administered every two weeks, was performed in patients with solid tumours...... and no other treatments or advanced CC. In the Phase II part response rate, toxicity, progression-free survival (PFS) and overall survival was evaluated in patients with newly diagnosed advanced CC. Results. Thirty-six patients entered the Phase I part and G 1 000 mg/m(2) day 1 and 15, O 60 mg/m(2) day 1...... and 15, and C 1 000 mg/m(2) BID day 1-7 and day 15-21 were established as MTD. In the Phase II part, 41 patients with advanced CC were included. Overall response rate was 34% and 51% had stable disease, resulting in a clinical benefit rate of 85%. Grade III and IV adverse events were rare. Median...

A quality assurance audit: phase iii trial of maximal androgen deprivation in prostate cancer (TROG 96.01)

International Nuclear Information System (INIS)

Steigler, A.; Kovacev, O.; Denham, J.; Lamb, D.; North, J.

2000-01-01

In 1997 the Trans-Tasman Radiation Oncology Group (TROG) performed a quality assurance (QA) audit of its phase III randomized clinical trial investigating the effectiveness of different durations of maximal androgen deprivation prior to and during definitive radiation therapy for locally advanced carcinoma of the prostate (TROG 96.01). The audit reviewed a total of 60 cases from 15 centres across Australia and New Zealand. In addition to verification of technical adherence to the protocol, the audit also incorporated a survey of centre planning techniques and a QA time/cost analysis. The present report builds on TROG's first technical audit conducted in 1996 for the phase III accelerated head and neck trial (TROG 91.01) and highlights the significant progress TROG has made in the interim period. The audit provides a strong validation of the results of the 96.01 trial, as well as valuable budgeting and treatment planning information for future trials. Overall improvements were detected in data quality and quantity, and in protocol compliance, with a reduction in the rate of unacceptable protocol violations from 10 to 4%. Audit design, staff education and increased data management resources were identified as the main contributing factors to these improvements. In addition, a budget estimate of $100 per patient has been proposed for conducting similar technical audits. The next major QA project to be undertaken by TROG during the period 1998-1999 is an intercentre dosimetry study. Trial funding and staff education have been targeted as the key major issues essential to the continued success and expansion of TROG's QA programme. Copyright (1999) Blackwell Science Pty Ltd

Phase transition of solid bismuth under high pressure

International Nuclear Information System (INIS)

Chen Hai-Yan; Xiang Shi-Kai; Yan Xiao-Zhen; Zhang Yi; Liu Sheng-Gang; Bi Yan; Zheng Li-Rong

2016-01-01

As a widely used pressure calibrator, the structural phase transitions of bismuth from phase I, to phase II, to phase III, and then to phase V with increasing pressure at 300 K have been widely confirmed. However, there are different structural versions for phase III, most of which are determined by x-ray diffraction (XRD) technology. Using x-ray absorption fine structure (XAFS) measurements combined with ab initio calculations, we show that the proposed incommensurate composite structure of bismuth of the three configurations is the best option. An abnormal continuous increase of the nearest-neighbor distance of phase III with elevated pressure is also observed. The electronic structure transformation from semimetal to metal is responsible for the complex behavior of structure transformation. (paper)

Performance of RF power and phase control on JT-60 LHRF heating system

International Nuclear Information System (INIS)

Fujii, T.; Ikeda, Y.; Imai, T.; Honda, M.; Kiyono, K.; Maebara, S.; Saigusa, M.; Sakamoto, K.; Sawahata, M.; Seki, M.

1987-01-01

The performance of RF power and phase control on the JT-60 LHRFD heating system are presented. The JT-60 LHRF heating system has three units of huge RF source with a total output of 24 MW, each unit consisting of eight amplifier chains. A high power klystron generating 1 MW for 10 s at 2 GHz is used in each chain. Automatic gain control is employed to regulate the output power not only against gain fluctuations in the chain but also against the unstable plasma load without any output circulator for the klystron

Non-power law behavior of the radial profile of phase-space density of halos

International Nuclear Information System (INIS)

Popolo, A. Del

2011-01-01

We study the pseudo phase-space density, ρ(r)/σ 3 (r), of ΛCDM dark matter halos with and without baryons (baryons+DM, and pure DM), by using the model introduced in Del Popolo (2009), which takes into account the effect of dynamical friction, ordered and random angular momentum, baryons adiabatic contraction and dark matter baryons interplay. We examine the radial dependence of ρ(r)/σ 3 (r) over 9 orders of magnitude in radius for structures on galactic and cluster of galaxies scales. We find that ρ(r)/σ 3 (r) is approximately a power-law only in the range of halo radius resolved by current simulations (down to 0.1% of the virial radius) while it has a non-power law behavior below the quoted scale, with inner profiles changing with mass. The non-power-law behavior is more evident for halos constituted both of dark matter and baryons while halos constituted just of dark matter and with angular momentum chosen to reproduce a Navarro-Frenk-White (NFW) density profile, are characterized by an approximately power-law behavior. The results of the present paper lead to conclude that density profiles of the NFW type are compatible with a power-law behavior of ρ(r)/σ 3 (r), while those flattening to the halo center, like those found in Del Popolo (2009) or the Einasto profile, or the Burkert profile, cannot produce radial profile of the pseudo-phase-space density that are power-laws at all radii. The results argue against universality of the pseudo phase-space density and as a consequence argue against universality of density profiles constituted by dark matter and baryons as also discussed in Del Popolo (2009)

Nitrato-complexes of Y(III), La(III), Ce(III), Pr(III), Nd(III), Sm(III), Gd(III), Tb(III), Dy(III) and Ho(III) with 2-(2'-pyridyl) benzimidazole

Energy Technology Data Exchange (ETDEWEB)

Mishra, A; Singh, M P; Singh, V K

1982-05-01

The nitrato-complexes, (Y(PyBzH)/sub 2/(NO/sub 3/)/sub 2/)NO/sub 3/.H/sub 2/O and Nd, Sm, Gd, Tb, Dy, Ho ; n=1-3, m=0-0.5 ; PyBzh=2-(2 -pyridyl)benzimidazole) are formed on interaction of the ligand with metal nitrates in ethanol. The electrical conductance values (116-129 ohm/sup -1/cm/sup 2/mol/sup -1/) suggest 1:1 electrolyte-nature of the complexes. Magnetic moment values of Ce(2.53 B.M.), Pr(3.62 B.M.), Nd(3.52 B.M.), Sm(1.70 B.M.), Gd(8.06 B.M.), Tb(9.44 B.M.), Dy(10.56 B.M.) and Ho(10.51 B.M.) in the complexes confirm the positive state of the metals. Infrared evidences are obtained for the existance of both coordinated (C/sub 2/v) and uncoordinated (D/sub 3/h) nitrate groups. Electronic absorption spectra of Pr(III)-, Nd(III)-, Sm(III)-, Tb(III)-, Dy(III)- and Ho(III)-complexes have been analysed in the light of LSJ terms.

Nitrato-complexes of Y(III), La(III), Ce(III), Pr(III), Nd(III), Sm(III), Gd(III), Tb(III), Dy(III) and Ho(III) with 2-(2'-pyridyl) benzimidazole

International Nuclear Information System (INIS)

Mishra, A.; Singh, M.P.; Singh, V.K.

1982-01-01

The nitrato-complexes, [Y(PyBzH) 2 (NO 3 ) 2 ]NO 3 .H 2 O and Nd, Sm, Gd, Tb, Dy, Ho ; n=1-3, m=0-0.5 ; PyBzh=2-(2 -pyridyl)benzimidazole] are formed on interaction of the ligand with metal nitrates in ethanol. The electrical conductance values (116-129 ohm -1 cm 2 mol -1 ) suggest 1:1 electrolyte-nature of the complexes. Magnetic moment values of Ce(2.53 B.M.), Pr(3.62 B.M.), Nd(3.52 B.M.), Sm(1.70 B.M.), Gd(8.06 B.M.), Tb(9.44 B.M.), Dy(10.56 B.M.) and Ho(10.51 B.M.) in the complexes confirm the terpositive state of the metals. Infrared evidences are obtained for the existance of both coordinated (C 2 v) and uncoordinated (D 3 h) nitrate groups. Electronic absorption spectra of Pr(III)-, Nd(III)-, Sm(III)-, Tb(III)-, Dy(III)- and Ho(III)-complexes have been analysed in the light of LSJ terms. (author)