WorldWideScience

Sample records for potencial cognitivo p300

  1. Correlação do potencial evocado P300 com aspectos cognitivos e depressivos do envelhecimento Correlation of the P300 evoked potential in depressive and cognitive aspects of aging

    Directory of Open Access Journals (Sweden)

    Elisiane Crestani de Miranda

    2012-10-01

    Full Text Available O P300 é um potencial evocado auditivo de longa latência dependente das habilidades cognitivas. Acredita-se que alterações cognitivas decorrentes ou não por sintomas depressivos possam interferir no P300. OBJETIVO: Verificar a influência do envelhecimento, dos aspectos cognitivos e depressivos na latência do P300 em idosos. MÉTODO: Estudo clínico e experimental com 60 idosos com perda auditiva neurossensorial de grau leve a moderadamente grave, sendo 20 do sexo masculino e 40 feminino e idade média de 71,1 anos. Os participantes realizaram o potencial evocado auditivo de longa latência, no qual foi estudada a latência do P300 (milissegundos. Os aspectos cognitivos foram avaliados por meio do Miniexame do Estado Mental (MEEM e Escala de Avaliação da Doença de Alzheimer (ADAS-Cog. Na avaliação da sintomatologia depressiva, foi aplicada a Escala de Depressão Geriátrica (EDG-15. RESULTADOS: Observou-se uma correlação positiva significante entre a Latência e Idade (p = 0,031. Entretanto, não houve diferença significante entre a latência do P300 e as categorias do ADAS-Cog (p = 0,584, MEEM (p = 0,199 e EDG (p = 0,541. CONCLUSÃO:O avanço da idade ocasionou um aumento da latência do P300, porém, o desempenho cognitivo e a presença de sintomatologia depressiva não influenciaram os resultados do P300 nesta população de idosos.The P300 is a long-latency auditory evoked potential highly dependent on cognitive skills. It is believed that cognitive changes caused or not by depressive symptoms may interfere with the P300. AIM: To investigate the influence of aging, cognitive and depression aspects of the P300 latency in elderly people. METHODS: Clinical and experimental study with 60 elderly patients with sensorineural hearing loss of mild to moderately severe level, 20 males and 40 females, average age of 71.1. Participants were submitted to the long latency auditory evoked potential, in which the P300 latency (milliseconds

  2. Potencial cognitivo y envejecimiento

    Directory of Open Access Journals (Sweden)

    María Belén BUENO MARTÍNEZ

    2009-11-01

    Full Text Available RESUMEN: Se parte de una consideración del desarrollo cognitivo como un fenómeno intrínsecamente contextual. Con ello se defiende que el desarrollo procede en cualquier etapa integrando los factores genéticos y experienciales. Esto se ve claramente en el envejecimiento intelectual. La mente que envejece presenta dos caras: la mecánica fluida y la pragmática cristalizada. Los resultados de la investigación indican que la mecánica cognitiva presenta pérdidas consistentes con el envejecimiento que se pueden paliar, en parte, con el entrenamiento. Por el contrario, la pragmática cognitiva, representada por el conocimiento profesional experto y la sabiduría, manifiesta estabilidad e incluso progreso a lo largo de la vejez. Se revisan los resultados más importantes de la investigación sobre las dos áreas prototípicas de la pragmática cognitiva, insistiendo especialmente en el campo emergente de la sabiduría. Se concluye enfatizando el papel compensador y enriquecedor del conocimiento y de la cultura y sus implicaciones para la educación gerontológica.ABSTRACT: The present work starts out from the tenet that cognitive development is intrinsically contextual. With this it is possible to defend the stance that the development occurs in any stage through an integration of genetic and experiential factors. This is clearly seen in intellectual aging. The aging mind has two faces: the fluid mechanical face and the cristallized pragmatic one. The results of the investigation show that cognitive mechanics presents consistent losses with aging that can be partly palliated with training. Conversely, cognitive pragmatics, represented by expert professional knowledge and wisdom, is stabilized and even progresses with aging. A review is made of the most important results of research into the two prototypical areas of cognitive knowledge, placing special emphasis on the emerging field of wisdom. The work is concluded highlighting the compensatory

  3. O potencial evocado cognitivo em adultos normais

    Directory of Open Access Journals (Sweden)

    Franco Glaucio M.

    2001-01-01

    Full Text Available O objetivo deste estudo foi avaliar os resultados do potencial cognitivo auditivo em um grupo de adultos normais. Os testes foram realizados registrando-se a resposta evocada em Cz e Fz. Os dados obtidos foram analisados estatisticamente. São descritas neste trabalho as latências médias de N1, P2, P2AP, N2 e P3, a amplitude de P3, bem como o desvio padrão destas variáveis. Comentam-se algumas dificuldades encontradas na interpretação do teste destacando as limitações de seu uso clínico.

  4. Effects of caffeine on visual evoked potencial (P300 and neuromotor performance Efeitos da ingestão de cafeína no potencial evocado visual (p300 e no desempenho neuromotor

    Directory of Open Access Journals (Sweden)

    Andréa Camaz Deslandes

    2004-06-01

    Full Text Available The stimulant effects of caffeine on cognitive performance have been widely investigated. The visual evoked potential, specially the P300 component, has been used in studies that explain the stimulant mechanisms of caffeine through neurophysiological methods. In this context, the present study aimed to investigate electrophysiological changes (P300 latency and modification of cognitive and motor performance produced by caffeine. Fifteen healthy volunteers, 9 women and 6 men (26 ± 5 years, 67 ± 12.5kg were submitted three times to the following procedure: electroencefalographic recording, Word Color Stroop Test, and visual discrimination task. Subjects took a gelatin caffeine capsule (400 mg or a placebo (P1 and P2, in a randomized, crossover, double-blind design. A one-factor ANOVA and Tukey’ post hoc test were used to compare dependent variables on the C, P1 and P2 moments. The statistical analyses indicated a non-significant decrease in reaction time, Stroop execution time and latency at Cz on the caffeine moment when compared to the others. Moreover, a non-significant increase in Stroop raw score and latency at Pz could be observed. The only significant result was found at Fz. These findings suggest that the positive tendency of caffeine to improve cognitive performance is probably associated with changes in the frontal cortex, a widely recognized attention area.Os efeitos estimulantes da cafeína no desempenho cognitivo vêm sendo amplamente investigados. O potencial evocado visual (P300 tem sido empregado em estudos recentes que buscam elucidar os mecanismos excitatórios da cafeína através de métodos neurofisiológicos. Neste contexto, o presente estudo objetivou examinar as variações geradas pela cafeína em respostas eletrofisiológicas (latência do P300 e determinar modificações no desempenho cognitivo e motor. Para tanto, 15 indivíduos hígidos, sendo 9 mulheres e 6 homens (26 ± 5 anos, 67 ± 12,5 kg foram submetidos por

  5. Neuromodulatory effects of caffeine and bromazepam on visual event-related potential (P300: a comparative study Efeitos neuromoduladores da cafeína e do bromazepam no potencial evocado visual relacionado a evento (P300: estudo comparativo

    Directory of Open Access Journals (Sweden)

    Mariana Montenegro

    2005-06-01

    Full Text Available The P300 component of the event-related potential (ERP is a general measurement of "cognitive efficiency". It is an index of the ability of an individual's central nervous system (CNS to process incoming information. OBJECTIVE: To compare the neuromodulatory effects of caffeine and bromazepam on the visual ERP (P300, in relation to a P300 normative database. METHOD: 15 right-handed individuals (7 male and 8 female, between 20 and 30 years of age, healthy, free of any cognitive impairment and not making use of psychoactive substances were studied. Participants were submitted to a visual discrimination task, which employed the "oddball" paradigm, after the administration of caffeine and bromazepam, in a randomized, double-blind design. RESULTS: Statistically significant differences were observed when the caffeine and bromazepam conditions were compared to the normative database. CONCLUSION: The present results suggest that caffeine and bromazepam have distinct modulatory effects on CNS functioning.O componente P300 do potencial evocado relacionado a evento é uma medida geral de "eficiência cognitiva" e um índice da qualidade do processamento e armazenamento de informações pelo sistema nervoso central (SNC. OBJETIVO: Comparar os efeitos neuromoduladores da cafeína e do bromazepam a partir do banco normativo do potencial evocado visual (P300. MÉTODO: 15 sujeitos destros (7 homens e 8 mulheres, entre 20 e 30 anos de idade, sadios, livres de qualquer déficit cognitivo e sem uso de substâncias psicotrópicas ou psicoativas foram estudados. Os sujeitos foram submetidos a uma tarefa de discriminação visual utilizando o paradigma "oddball", após a administração de uma cápsula de cafeína ou de bromazepam, em um desenho duplo-cego randomizado. RESULTADOS: Foram observadas diferenças estatisticamente significativas quando as condições cafeína e bromazepam foram comparadas com o banco normativo. CONCLUSÃO: Os resultados sugerem que a cafe

  6. Analysis of the influence of bromazepam on cognitive performance through the visual evoked potential (P300 Análise da influência do bromazepam na performance cognitiva através do potencial evocado visual (P300

    Directory of Open Access Journals (Sweden)

    Fernanda Puga

    2005-06-01

    Full Text Available Benzodiazepines have been used in the pharmacological treatment of anxiety for over four decades. However, very few studies have combined bromazepam and event-related potentials (ERP. The present study aimed at investigating the modulatory effects of this drug on brain dynamics. Specifically, the effects of bromazepam (3mg on the P300 component of the ERP were tested in a double-blind experiment. The sample, consisting of 15 healthy subjects (7 male and 8 female, was submitted to a visual discrimination task, which employed the "oddball" paradigm. Electrophysiological (P300 and behavioral measures (stroop, digit span, and reaction time were analyzed across three experimental conditions: placebo 1, placebo 2, and bromazepam. Results suggest that the effects of bromazepam (3mg on cognitive processes are not apparent. In spite of what seems irrefutable in current literature, bromazepam did not produce evident effects on the behavioral and electrophysiological variables analyzed.Benzodiazepínicos têm sido utilizados no tratamento farmacológico da ansiedade há mais de quatro décadas. No entanto, poucos estudos têm combinado bromazepam e potencial evocado relacionado a evento (PRE. O presente estudo teve por objetivo investigar os efeitos modulatórios desta droga na dinâmica cerebral. Especificamente, os efeitos de 3mg de bromazepam no componente P300 do PRE foram analisados em um experimento duplo-cego. A amostra consistiu de 15 sujeitos sadios (7 homens e 8 mulheres, submetidos a uma tarefa de discriminação visual utilizando o paradigma "oddball". Medidas eletrofisiológicas (P300 e comportamentais (stroop, digit span, e tempo de reação foram analisadas em três condições experimentais: placebo 1, placebo 2 e bromazepam. Os resultados sugerem que os efeitos de 3mg de bromazepam em processos cognitivos não são aparentes. Apesar do que parece irrefutável na literatura, o bromazepam não produziu efeitos evidentes nas vari

  7. Síndrome da apneia obstrutiva do sono e o potencial auditivo P300 Obstructive sleep apnea and P300 evoked auditory potential

    Directory of Open Access Journals (Sweden)

    Carlos Henrique Martins

    2011-12-01

    Full Text Available A Síndrome da Apneia Obstrutiva do Sono (SAOS diminui as capacidades da atenção, memória e concentração, fatores relacionados com a cognição. A análise dos parâmetros do P300 auditivo permitiria inferir disfunção cognitiva. OBJETIVO: Comparar os dados da polissonografia e do P300 auditivo em adultos, roncopatas primários com portadores de SAOS. CASUÍSTICA E MÉTODO: Estudo prospectivo em roncopatas primários (N=12 e em portadores de SAOS (N=54, submetidos à polissonografia definidos pelo índice de apneia e hipopneia (IAH. As variáveis da polissonografia e as do P300 foram comparadas, pelos testes "T" de Student, exato de Fisher, regressão logística e análise de correlação com nível de significância de 5%. RESULTADOS: O IAH apresentou correlação inversa com a oximetria em ambos os grupos. A prevalência do P300 foi menor no G.SAOS (teste exato de Fisher, p=0,027. A idade dos pacientes não influenciou a prevalência do P300 (análise de regressão; p=0,232. A amplitude do P300 foi menor do G.SAOS (teste "T" de Student; p=0,003 a latência do P300 foi semelhante em ambos os grupos (teste "T" de Student; p=0,89. CONCLUSÃO: A redução da amplitude do P300 nos portadores de SAOS sugere disfunção cognitiva induzida por diminuição da memória auditiva.The obstructive sleep apnea syndrome (OSAS reduces attention span, memory and concentration capacities, all associated with cognition. The analysis of the auditory P300 parameters could help infer cognitive dysfunction. OBJECTIVE: To compare the data from polysomnography and the auditory P300 in adults, primary snorers with OSAS patients. MATERIALS AND METHODS: Prospective study with primary snorers (N=12 and in OSAS patients (N=54, submitted to polysomnography, defined by the apnea-hypopnea index (AHI. The polysomnography and P300 variables were compared by the t-Student test, the Exact Fisher's Test, logistic regression and analysis of correlation with a significance

  8. Potencial evocado auditivo tardio relacionado a eventos (P300 na síndrome de Down Late auditory event-related evoked potential (P300 in Down's syndrome patients

    Directory of Open Access Journals (Sweden)

    Carla Patrícia Hernandez Alves Ribeiro César

    2010-04-01

    Full Text Available A síndrome de Down é causada pela trissomia do cromossomo 21 e está associada com alteração do processamento auditivo, distúrbio de aprendizagem e, provavelmente, início precoce de Doença de Alzheimer. OBJETIVO: Avaliar as latências e amplitudes do potencial evocado auditivo tardio relacionado a eventos (P300 e suas alterações em indivíduos jovens adultos com síndrome de Down. MATERIAL E MÉTODO: Estudo de caso prospectivo. Latências e amplitudes do P300 foram avaliadas em 17 indivíduos com síndrome de Down e 34 indivíduos sadios. RESULTADOS: Foram identificadas latências do P300 (N1, P2, N2 e P3 prolongadas e amplitude N2 - P3 diminuída nos indivíduos com síndrome de Down quando comparados ao grupo controle. CONCLUSÃO: Em indivíduos jovens adultos com síndrome de Down ocorre aumento das latências N1, P2, N2 e P3, e diminuição significativa da amplitude N2-P3 do potencial evocado auditivo tardio relacionado a eventos (P300, sugerindo prejuízo da integração da área de associação auditiva com as áreas corticais e subcorticais do sistema nervoso central.Down syndrome is caused by a trisomy of chromosome 21 and is associated with central auditory processing deficit, learning disability and, probably, early-onset Alzheimer's disease. AIM: to evaluate the latencies and amplitudes of evoked late auditory potential related to P300 events and their changes in young adults with Down's syndrome. MATERIALS AND METHODS: Prospective case study. P300 test latency and amplitudes were evaluated in 17 individuals with Down's syndrome and 34 healthy individuals. RESULTS The P300 latency (N1, P2, N2 and P3 was longer and the N2-P3 amplitude was lower in individuals with Down syndrome when compared to those in the control group. CONCLUSION: In young adults with Down syndrome, N1, P2, N2 and P3 latencies of late auditory evoked potential related to P300 events were prolonged, and N2 - P3 amplitudes were significantly reduced

  9. Evidencias de compromiso cerebral en el estadio crónico de la enfermedad de Chagas obtenidas por medio del potencial P300 y de electroencefalografía cuantificada

    Directory of Open Access Journals (Sweden)

    PROST JULIO OSCAR

    2000-01-01

    Full Text Available Es reconocido el compromiso del sistema nervioso periférico en la etapa crónica de la enfermedad de Chagas, incorporándose últimamente evidencias tomográficas y neuropsicológicas de compromiso cerebral. Con el objetivo de evaluar dicho compromiso por medio del potencial P 300 y la electroencefalografía cuantificada (EEGc se estudiaron 35 pacientes (26 a 55 años, comparados con un grupo control de similar número y edad (29 a 55 años. Se observó: latencia de la onda P 3 mayor en el grupo en estudio (331,24 ± 24,02 contra 318,86 ± 23,18 (p=0,01716. El EEGc mostró diferencias en la potencia relativa de la banda Beta 1, menor en los pacientes (p=1,62834E5 y en la frecuencia dominante, 1 Hz menor en los chagasicos (p=0,01077. El análisis multivariado discrimina tres subpoblaciones: una normal, una de enfermos con incremento alfa y otra de enfermos con decremento alfa e incremento delta y theta (p=0,00004. La proporción de resultados patológicos fue del 20 % en los EEGc y el 11,43 % en los potenciales cognitivos. No se correlacionó el compromiso neurológico y el cardíaco. Se concluye que existen francos indicadores electrofisiológicos de compromiso cerebral en el estadio crónico de la enfermedad de Chagas, hallazgo que refuerza a los obtenidos por otros métodos.

  10. Auditory evoked potential P300 in adults: reference values.

    Science.gov (United States)

    Didoné, Dayane Domeneghini; Garcia, Michele Vargas; Oppitz, Sheila Jacques; Silva, Thalisson Francisco Finamôr da; Santos, Sinéia Neujahr Dos; Bruno, Rúbia Soares; Filha, Valdete Alves Valentins Dos Santos; Cóser, Pedro Luis

    2016-01-01

    To establish reference intervals for cognitive potential P300 latency using tone burst stimuli. This study involved 28 participants aged between 18 and 59 years. P300 recordings were performed using a two-channel device (Masbe, Contronic). Electrode placement was as follows: Fpz (ground electrode), Cz (active electrode), M1 and M2 (reference electrodes). Intensity corresponded to 80 dB HL and frequent and rare stimulus frequencies to 1,000Hz and 2,000Hz, respectively. Stimuli were delivered binaurally. Mean age of participants was 35 years. Average P300 latency was 305ms. Maximum acceptable P300 latency values of 362.5ms (305 + 2SD 28.75) were determined for adults aged 18 to 59 years using the protocol described. Estabelecer valores de referência para a latência do potencial cognitivo P300 com estímulos tone burst. Participaram do estudo 28 indivíduos entre 18 e 59 anos. O registro do P300 foi realizado no equipamento Masbe da marca Contronic. Os eletrodos foram fixados nas posições Fpz (eletrodo terra), Cz (eletrodo ativo), M1 e M2 (eletrodos referência). A intensidade foi de 80 dB NA. A frequência do estímulo frequente foi de 1.000Hz e a do estímulo raro de 2.000Hz. Os estímulos foram apresentados na forma binaural. A média de idade dos indivíduos foi de 35 anos. A média de latência para P300 de 305ms. Usando o protocolo descrito, o valor máximo de latência aceitáveis para P300 foram de 362,5ms (305 + 2DP 28,75) na faixa etária do adulto de 18 a 59 anos.

  11. Avaliação pelo P300 de crianças com e sem epilepsia e rendimento escolar

    OpenAIRE

    VISIOLI-MELO,JUCELEI F.; ROTTA,NEWRA TELLECHEA

    2000-01-01

    Dificuldade de aprendizagem é situação comum em crianças com epilepsia. Distúrbios da inteligência têm sido associados com epilepsia. O potencial cognitivo (P300) é um adjunto clínico para mensurar neurofisiologicamente o processo cognitivo. Foram estudadas 99 crianças com 10 anos a 11 anos e 11 meses. Do Grupo I, sem epilepsia, faziam parte 64 crianças, das quais 32 com bom rendimento e outras 32 com mau rendimento escolar. Do Grupo II, com epilepsia, faziam parte 35 crianças, sendo 21 com b...

  12. Potencial evocado auditivo de longa latência-P300 em indivíduos normais: valor do registro simultâneo em Fz e Cz P300-long-latency auditory evoked potential in normal hearing subjects: simultaneous recording value in Fz and Cz

    Directory of Open Access Journals (Sweden)

    Josilene Luciene Duarte

    2009-04-01

    Full Text Available O P300 é um Potencial Evocado Auditivo denominado potencial endógeno por refletir o uso funcional que o indivíduo faz do estímulo auditivo, sendo altamente dependente das habilidades cognitivas, entre elas atenção e discriminação auditiva. É um procedimento de avaliação objetiva, mas que depende da experiência do avaliador em detectar os picos das ondas, sendo importante a utilização de métodos de registro que facilitem a análise da presença de resposta e a interpretação dos resultados. OBJETIVO: Analisar o Potencial Evocado Auditivo de Longa Latência-P300 obtido com a utilização de dois eletrodos ativos posicionados em Fz e Cz. MATERIAIS E MÉTODOS: Participaram deste estudo 33 indivíduos de ambos os gêneros com idade entre 7 e 34 anos, audição normal e sem fator de risco para problemas mentais. RESULTADOS: Os resultados demonstraram que não houve diferença estatisticamente significante para a latência de N2 e P3 e amplitude do P3 quando analisado o gênero e nem correlação com a idade dos indivíduos. Houve forte correlação destas medidas com o posicionamento dos eletrodos em Fz e Cz. CONCLUSÃO: O posicionamento dos eletrodos ativos em Fz e Cz pode ser considerado um recurso a mais para auxiliar na análise clínica do P300.The P300 is and auditory Evoked Potential, called endogenous potential because it reflects the functional use the individual makes of the auditory stimulus, being highly dependent on cognitive skills; among them we list attention and auditory discrimination. It is a procedure of objective evaluation; however, one that depends on the examiner's experience to detect wave peaks, and it is important to use recording methods that facilitate the response presence analysis and result interpretation. AIM: to analyze the P300 Long Latency Auditory Evoked Potential obtained through the use of two active electrodes positioned on Fz and Cz. MATERIALS AND METHODS: 330 individuals from both genders and

  13. Utilidad de la onda P300 como marcador de fatiga cognitiva en médicos internos residentes tras una jornada laboral de 24 horas

    OpenAIRE

    Estarelles Marco, María Jesús

    2015-01-01

    La onda P300 fue el primer potencial evocado cognitivo que se conoció, descrita en 1965 por Sutton et al. Se caracteriza por una gran onda positiva, máxima en línea media del cuero cabelludo, que aparece alrededor de 300 milisegundos después de un estímulo infrecuente y relevante para una tarea. Viene determinada por la latencia al pico máximo y por su amplitud, parámetros que pueden afectarse por la privación de sueño, como se ha visto en estudios previos. La afectación de las habilidade...

  14. Avaliação pelo P300 de crianças com e sem epilepsia e rendimento escolar Assessment through P300 of epileptic and non-epileptic children and school performance

    Directory of Open Access Journals (Sweden)

    JUCELEI F. VISIOLI-MELO

    2000-06-01

    Full Text Available Dificuldade de aprendizagem é situação comum em crianças com epilepsia. Distúrbios da inteligência têm sido associados com epilepsia. O potencial cognitivo (P300 é um adjunto clínico para mensurar neurofisiologicamente o processo cognitivo. Foram estudadas 99 crianças com 10 anos a 11 anos e 11 meses. Do Grupo I, sem epilepsia, faziam parte 64 crianças, das quais 32 com bom rendimento e outras 32 com mau rendimento escolar. Do Grupo II, com epilepsia, faziam parte 35 crianças, sendo 21 com bom rendimento escolar e 15 com mau rendimento escolar. Não foi encontrada diferença significativa na latência do P300 entre os dois grupos. Quando foram estratificados segundo o desempenho escolar, as crianças do Grupo I, com bom rendimento escolar, apresentaram latência do P300 de 336 ms e as com mau rendimento escolar, latência de 382 ms; as crianças do Grupo II, com bom rendimento escolar, apresentaram latência do P300 de 363 ms e as com mau rendimento escolar, latência de 400 ms, com diferença significativa. Essa diferença estava localizada entre as crianças não epilépticas com bom desempenho escolar e as com mau desempenho escolar, epilépticas ou não.Learning disability is common in epileptic children. Epilepsy has been associated with disorders of intelligence. Cognitive potential (P300 is considered to be a clinical aid in the neurophysiological measurement of the cognitive process. Ninety-nine children between the ages of 10 years and 11 years and 11 months formed our sample, with good and poor school performance. Group I, non-epileptic, had 64 children of whom 32 had good and 32 poor school performance. Group II, epileptic, had 35 children, of whom 21 had good and 15 poor school performance. No significant difference in P300 latency was found between Groups I and II. When groups were stratified based on school performance, Group I children with good school performance had P300 latency of 336 ms, while the ones with poor

  15. Avaliação de pacientes com distrofia muscular de Duchenne através de testagem neuropsicológica e do potencial evocado cognitivo (P300) /

    OpenAIRE

    Della Coletta, Marcus Vinicius

    2006-01-01

    Orientadora: Rosana Herminia Scola Dissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências da Saúde, Programa de Pós-Graduação em Medicina Interna. Defesa: Curitiba, 2006 Inclui bibliografia e anexos

  16. Avaliação dos potenciais evocados relacionados a eventos (ERP-P300 em pacientes com cirrose hepática sem encefalopatia Evaluation of the event-related potential (ERP-P300 in patients with hepatic cirrhosis without encephalopathy

    Directory of Open Access Journals (Sweden)

    Vinicius Teodoro

    2008-03-01

    Full Text Available RACIONAL: Na cirrose hepática ocorrem alterações na estrutura do fígado, levando à perda das funções do órgão, com conseqüências neuropsiquiátricas, como disfunções cognitivas. Um dos meios mais efetivos para avaliar objetivamente as funções cognitivas é medir a atividade eletrofisiológica do sistema nervoso central através do potencial evocado relacionado a eventos (ERP-P300. OBJETIVO: Estudar a utilidade do potencial evocado relacionado a eventos (ERP, para avaliar distúrbios cognitivos em pacientes com cirrose hepática e como auxiliar no diagnóstico da encefalopatia hepática mínima. MÉTODO: Foram selecionados 50 pacientes, diagnosticados com cirrose hepática sem sinais clínicos de encefalopatia hepática e 35 voluntários saudáveis de idades e sexo semelhantes. Em todos os pacientes foram realizados exames clínico-neurológico e laboratoriais. Para identificação do prejuízo cognitivo foi utilizado o ERP-P300 e obtida a média da latência da onda P300. RESULTADOS: Houve diferença significativa entre as médias da latência do ERP-P300 do grupo cirrótico e controle. CONCLUSÃO: A realização do ERP-P300 é simples, depende de fatores controláveis de variação e tem fácil reprodutibilidade, podendo ser útil para o rastreio de distúrbios cognitivos em pacientes com cirrose e auxiliar no diagnóstico de encefalopatia hepática mínima.BACKGROUND: In hepatic cirrhosis structural liver alterations occur leading to the loss of the organ functions with neuro-psychiatric consequence, as cognitive dysfunctions. One of the most effective ways of objectively evaluating cognition is to measure electrophysiological activity in the central nervous system trough event-related potentials (ERP-P300. AIM: To assess the value of the event-related potential (ERP in order to determine cognitive disturbances in patients with liver cirrhosis and to assist in the diagnosis of minimal hepatic encephalopathy. METHODS: Fifty

  17. Investigação da estabilidade inter e intra-examinador na identificação do P300 auditivo: análise de erros

    Directory of Open Access Journals (Sweden)

    Junqueira Cinthia A.O.

    2002-01-01

    Full Text Available Introdução: A possibilidade de correlacionar aspectos do comportamento auditivo (habilidades auditivas a fenômenos fisiológicos observáveis (potencial cognitivo - P300 tem despertado o interesse dos profissionais interessados no estudo das disfunções auditivas. Porém, os métodos de análise do P300 e interpretação dos resultados ainda não estão padronizados e devem ser explorados e discutidos visando maior segurança para aplicação clínica e científica. Objetivo: Este estudo investigou a estabilidade na análise e interpretação do P300 auditivo seguindo um conjunto de regras (critério pré-determinadas. Forma de estudo: Clínico prospectivo. Material e método: Traçados de P300 de crianças e adolescentes saudáveis foram analisados, em 2 momentos diferentes, seguindo as mesmas regras para a identificação e marcação das ondas N1, P2, N2 e P3. As medidas de latência da onda P300 foram submetidas a análises qualitativa e quantitativa. A análise qualitativa investigou os tipos de erros cometidos pelo examinador no uso do critério de determinação do P300 (5,9% do total de 560 medidas obtidas. A análise quantitativa investigou a variabilidade da medida da latência do P300 atribuível ao examinador. Resultado: Os resultados mostraram que não houve diferença significante entre as análises inter e intra-examinador, tendo sido encontradas correlações significantes entre as medidas de latência, indicando boa fidedignidade no teste-reteste e alta concordância entre os examinadores no modo como analisaram os traçados das ondas. Conclusão: O critério usado neste estudo demonstrou ser útil na determinação do P300, podendo ser sugerido com segurança para uso clínico e científico.

  18. Potencial evocado cognitivo e desordem de processamento auditivo em crianças com distúrbios de leitura e escrita Cognitive evoked potentials and central auditory processing in children with reading and writing disorders

    Directory of Open Access Journals (Sweden)

    Gislaine Richter Minhoto Wiemes

    2012-06-01

    Full Text Available As dificuldades na aprendizagem escolar muitas vezes podem ser causadas por uma alteração do Processamento Auditivo - PA. OBJETIVO: Identificar se acima da média dos valores de latência do P300, num grupo de indivíduos com Distúrbio de Leitura e Escrita, também seriam encontradas alterações no teste Staggered Spondaic Word - SSW e no teste de Fala no Ruído que sugerissem Desordem do Processamento Auditivo - DPA. MATERIAL E MÉTODOS: Estudo de coorte transversal. Foram avaliados 21 indivíduos com distúrbio de leitura e escrita, idade entre 7 e 14 anos. RESULTADOS: Todos apresentaram resultados normais no exame otorrinolaringológico, na avaliação audiológica e Potencial Evocado Auditivo de Tronco Encefálico. Fazendo-se a média aritmética de todos os valores de latência do P300 obtidos, chegou-se à média de 334,25 ms, sendo divididos em dois grupos: grupo "A", com média da latência acima de 335 ms, e "B", com latência abaixo de 335 ms. Nos indivíduos do grupo "A", foram realizados os testes SSW e Fala no Ruído. CONCLUSÃO:O presente estudo pode concluir que foram encontradas alterações nos testes de fala dicótica (SSW e de Fala no Ruído no grupo de indivíduos com Distúrbio da Escrita e Leitura com valores de latência do P300 acima de 335 ms, sugerindo DPA.Learning disorders are often magnified by auditory processing disorders (APD. OBJECTIVE: This paper aims to verify whether individuals with reading and writing disorders and P300 latencies above the average also present altered Staggered Spondaic Word (SSW and speech-in-noise test results suggestive of APD. MATERIALS AND METHODS: This is a cross-sectional cohort study. Twenty-one individuals with reading and writing disorders aged between 7 and 14 years were enrolled. RESULTS: All subjects had normal findings on ENT examination, audiological tests, and brainstem auditory evoked potentials. The average P300 latency (334,25 ms of all patients was picked as a cutoff

  19. P300 is attenuated during dissociative episodes.

    Science.gov (United States)

    Kirino, Eiji

    2006-02-01

    The present study examined the pathophysiology of dissociative phenomena using the P300 component of event-related potentials, quantitative electroencephalography (QEEG), and morphology measures of computed tomography scan. Event-related potentials during an auditory oddball paradigm and QEEG in resting state were recorded. Patients exhibited attenuation of P300 amplitudes compared with controls during dissociative episodes, but exhibited recovery to control levels in remission. Patients had a larger Sylvian fissure-brain ratio than did controls. QEEG findings revealed no significant differences between the patients and controls or between episodes and remission in the patient group. Attenuation of the P300 can be interpreted as the result of a negative feedback loop from the medial temporal lobe to the cortex, which decreases the amount of information flow, allocation of attentional resources, and updating of working memory to avoid both excessive long-term memory system activity in medial temporal lobe and resurgence of affect-laden memories.

  20. Empathy, motivation, and P300 BCI performance.

    Science.gov (United States)

    Kleih, Sonja C; Kübler, Andrea

    2013-01-01

    Motivation moderately influences brain-computer interface (BCI) performance in healthy subjects when monetary reward is used to manipulate extrinsic motivation. However, the motivation of severely paralyzed patients, who are potentially in need for BCI, could mainly be internal and thus, an intrinsic motivator may be more powerful. Also healthy subjects who participate in BCI studies could be internally motivated as they may wish to contribute to research and thus extrinsic motivation by monetary reward would be less important than the content of the study. In this respect, motivation could be defined as "motivation-to-help." The aim of this study was to investigate, whether subjects with high motivation for helping and who are highly empathic would perform better with a BCI controlled by event-related potentials (P300-BCI). We included N = 20 healthy young participants naïve to BCI and grouped them according to their motivation for participating in a BCI study in a low and highly motivated group. Motivation was further manipulated with interesting or boring presentations about BCI and the possibility to help patients. Motivation for helping did neither influence BCI performance nor the P300 amplitude. Post hoc, subjects were re-grouped according to their ability for perspective taking. We found significantly higher P300 amplitudes on parietal electrodes in participants with a low ability for perspective taking and therefore, lower empathy, as compared to participants with higher empathy. The lack of an effect of motivation on BCI performance contradicts previous findings and thus, requires further investigation. We speculate that subjects with higher empathy who are good perspective takers with regards to patients in potential need of BCI, may be more emotionally involved and therefore, less able to allocate attention on the BCI task at hand.

  1. Empathy, Motivation, and P300 BCI performance

    Directory of Open Access Journals (Sweden)

    Sonja C Kleih

    2013-10-01

    Full Text Available Motivation moderately influences Brain-Computer Interface (BCI performance in healthy subjects when monetary reward is used to manipulate extrinsic motivation. However, the motivation to use a BCI of severely paralyzed patients, who are potentially in need for BCI, could mainly be internal and thus, an intrinsic motivator may be more powerful. Also healthy subjects who participate in BCI studies could be intrinsically motivated as they may wish to contribute to research and thus extrinsic motivation by monetary reward would be less important than the content of the study. In this respect, motivation could be defined as motivation-to-help. The aim of this study was to investigate, whether subjects with high motivation for helping and who are highly empathic would perform better with a BCI controlled by event-related potentials (P300-BCI. We included N=20 healthy young participants naïve to BCI and grouped them according to their motivation for participating in a BCI study in a low and highly motivated group. Motivation was further manipulated with interesting or boring presentations about BCI and the possibility to help patients. Motivation for helping did neither influence BCI performance nor the P300 amplitude. Post-hoc, subjects were re-grouped according to their ability for perspective taking. We found significantly higher P300 amplitudes on parietal electrodes in participants with a low ability for perspective taking and therefore, lower empathy, as compared to participants with higher empathy. The lack of an effect of motivation on BCI performance contradicts previous findings and thus, requires further investigation. We speculate that subjects with higher empathy were less able to focus attention on the BCI task. Good perspective takers with regards to patients in potential need of BCI, may be more emotionally involved and therefore, less able to allocate attention on the BCI task at hand.

  2. Hiperactivacion cortical y deterioro cognitivo en esquizofrenia

    OpenAIRE

    Suazo Bonnelly, Vanessa Johanna

    2014-01-01

    [ES] En este trabajo se estudió la actividad cerebral desorganizada y el deterioro cognitivo adjudicado a pacientes con esquizofrenia. Para estudiar la actividad cerebral se empleó una medida electroencefalográfica de ruido cortical (actividad promediada de fondo no ligada a la tarea) durante el desarrollo de una tarea sencilla (P300) en dos de las bandas oscilatorias (gamma y theta) más asociadas a la organización de la actividad cerebral según la literatura. Se utilizó una medida estructura...

  3. P300 brain computer interface: current challenges and emerging trends

    Science.gov (United States)

    Fazel-Rezai, Reza; Allison, Brendan Z.; Guger, Christoph; Sellers, Eric W.; Kleih, Sonja C.; Kübler, Andrea

    2012-01-01

    A brain-computer interface (BCI) enables communication without movement based on brain signals measured with electroencephalography (EEG). BCIs usually rely on one of three types of signals: the P300 and other components of the event-related potential (ERP), steady state visual evoked potential (SSVEP), or event related desynchronization (ERD). Although P300 BCIs were introduced over twenty years ago, the past few years have seen a strong increase in P300 BCI research. This closed-loop BCI approach relies on the P300 and other components of the ERP, based on an oddball paradigm presented to the subject. In this paper, we overview the current status of P300 BCI technology, and then discuss new directions: paradigms for eliciting P300s; signal processing methods; applications; and hybrid BCIs. We conclude that P300 BCIs are quite promising, as several emerging directions have not yet been fully explored and could lead to improvements in bit rate, reliability, usability, and flexibility. PMID:22822397

  4. P300 event-related potentials in children with dyslexia.

    Science.gov (United States)

    Papagiannopoulou, Eleni A; Lagopoulos, Jim

    2017-04-01

    To elucidate the timing and the nature of neural disturbances in dyslexia and to further understand the topographical distribution of these, we examined entire brain regions employing the non-invasive auditory oddball P300 paradigm in children with dyslexia and neurotypical controls. Our findings revealed abnormalities for the dyslexia group in (i) P300 latency, globally, but greatest in frontal brain regions and (ii) decreased P300 amplitude confined to the central brain regions (Fig. 1). These findings reflect abnormalities associated with a diminished capacity to process mental workload as well as delayed processing of this information in children with dyslexia. Furthermore, the topographical distribution of these findings suggests a distinct spatial distribution for the observed P300 abnormalities. This information may be useful in future therapeutic or brain stimulation intervention trials.

  5. P300 brain potential among workers exposed to organic solvents

    Directory of Open Access Journals (Sweden)

    Bente E. Moen

    2009-10-01

    Full Text Available  SUMMARYThe P300 component of the auditory event-related brain potential was examined in a group of 11workers exposed to low levels of organic solvents in a paint factory and 11 unexposed controls beforeand after 3 weeks of summer vacation. The P300 latency time was found to be prolonged among theexposed workers compared to the reference group before the summer vacation, and to be significantlylonger before the vacation than after in the exposed group.The P300 component was also examined in a group of 85 seamen from chemical tankers, experiencingpeak exposures to organic solvents. They were compared to a reference group of unexposedseamen. Comparing these two groups, no difference was found in the P300 latency time. No relationshipbetween the P300 latency time and exposure was found in a multiple regression analysis, includingthe variables age, alcohol consumption, smoking and cerebral concussions.The study indicates the occurrence of an acute biological effect in the nervous system related toorganic solvent exposure, expressed by prolonged P300 latency time. This was found at very lowexposure levels and should be studied further.

  6. Regional cerebral blood flow and P300 in neurosurgical disorders

    International Nuclear Information System (INIS)

    Funahashi, Kazuyoshi; Hyoutani, Genhachi; Maeshima, Shinichirou; Miyamoto, Kazuki; Kuwata, Toshikazu; Terada, Tomoaki; Komai, Norihiko

    1990-01-01

    Changes in regional cerebral blood flow (rCBF), P300 and higher brain function were studied in neurosurgical patients with localized lesions on computed tomography (CT). Twenty-five patients ranging in age from 30 to 81 were studied. Nineteen of these suffered from cerebrovascular disease and six had tumors. Using the oddball paradigm, P300 components were elicited by rate tones (2 KHz) and recorded at Cz and Pz referred to linked ear-lobe electorodes. The P300 latencies of the patients were statistically compared with those of 27 normal subjects. Higher brain function was evaluated with the following psychological tests: a rating scale for psychological function (Sano and Tanemura), Mini-Mental State (MMS), Hasegawa's Dementia Scale (HDS) and the 'Kanahiroi' test. Regional CBF was measured in the bilateral cerebral cortices (the frontal, temporal and occipital lobes), thalamus and basal ganglia by means of a cold xenon CT method. The laterality indices of rCBF (Rt. rCBF/Lt. rCBF) in the bilateral symmetrical areas of the patients were compared to those of 8 normal subjects. Of the 25 patients, 12 revealed prolongation of P300 latency. Ten (86%) of the 12 with prolonged P300 latency showed reduction of rCBF in the right cerebral hemisphere (rt. frontal lobe, rt. thalamus and rt. basal ganglia). Significant correlations (P<0.025) were recognized between the P300 latencies and the laterality indices of rCBF in the frontal lobe and thalamus. There was a significant correlation (P<0.05) between the scores of MMS and HDS and the laterality indicies of rCBF in the frontal lobe only. In the 13 patients with normal P300 latency, 6 (46%) displayed no reduction in rCBF. The remaining 7 patients with normal P300 showed reduction of rCBF in the left hemisphere. Both right frontal lobe and right thalamus have an important role affecting the prolongation of P300 latency and disturbance of cognitive functions. (author)

  7. [Normative aspects of somatosensory evoked P300 components].

    Science.gov (United States)

    Louzã Neto, M R; Maurer, K; Neuhauser, B

    1989-06-01

    Using a somatosensory version of the oddball-paradigma the influence of age and gender on the P300-component and the comparison of the potential after stimulation of the right and left median nerve was studied in 30 healthy right handed volunteers (age: 20-35 years). Latency, amplitude, area and duration of the P300-potential were analysed. No relationship between age, gender and the P300-parameters were observed. The amplitude and the area of the potential obtained from the F3 electrode were greater after stimulation of the right median nerve compared to the potential after stimulation of the left median nerve. All other results were not significantly different. Strong positive correlations between the results after stimulation of the right and left median nerve were observed. These results showed that by a young group of volunteers age and gender did not influence the P300-component. Although the P300-Parameters had a between-subject variability, their mean remained constant over the study, their correlation coefficients were strong positive and the side of stimulation did not influence them (except for the electrode F3).

  8. P300 Event-Related Potentials in Children with Dyslexia

    Science.gov (United States)

    Papagiannopoulou, Eleni A.; Lagopoulos, Jim

    2017-01-01

    To elucidate the timing and the nature of neural disturbances in dyslexia and to further understand the topographical distribution of these, we examined entire brain regions employing the non-invasive auditory oddball P300 paradigm in children with dyslexia and neurotypical controls. Our findings revealed abnormalities for the dyslexia group in…

  9. Does the 'P300' speller depend on eye gaze?

    Science.gov (United States)

    Brunner, P.; Joshi, S.; Briskin, S.; Wolpaw, J. R.; Bischof, H.; Schalk, G.

    2010-10-01

    Many people affected by debilitating neuromuscular disorders such as amyotrophic lateral sclerosis, brainstem stroke or spinal cord injury are impaired in their ability to, or are even unable to, communicate. A brain-computer interface (BCI) uses brain signals, rather than muscles, to re-establish communication with the outside world. One particular BCI approach is the so-called 'P300 matrix speller' that was first described by Farwell and Donchin (1988 Electroencephalogr. Clin. Neurophysiol. 70 510-23). It has been widely assumed that this method does not depend on the ability to focus on the desired character, because it was thought that it relies primarily on the P300-evoked potential and minimally, if at all, on other EEG features such as the visual-evoked potential (VEP). This issue is highly relevant for the clinical application of this BCI method, because eye movements may be impaired or lost in the relevant user population. This study investigated the extent to which the performance in a 'P300' speller BCI depends on eye gaze. We evaluated the performance of 17 healthy subjects using a 'P300' matrix speller under two conditions. Under one condition ('letter'), the subjects focused their eye gaze on the intended letter, while under the second condition ('center'), the subjects focused their eye gaze on a fixation cross that was located in the center of the matrix. The results show that the performance of the 'P300' matrix speller in normal subjects depends in considerable measure on gaze direction. They thereby disprove a widespread assumption in BCI research, and suggest that this BCI might function more effectively for people who retain some eye-movement control. The applicability of these findings to people with severe neuromuscular disabilities (particularly in eye-movements) remains to be determined.

  10. P300 in individuals with sensorineural hearing loss

    Directory of Open Access Journals (Sweden)

    Ana Cláudia Mirandola Barbosa Reis

    2015-04-01

    Full Text Available INTRODUCTION: Behavioral and electrophysiological auditory evaluations contribute to the understanding of the auditory system and of the process of intervention.OBJECTIVE: To study P300 in subjects with severe or profound sensorineural hearing loss.METHODS: This was a descriptive cross-sectional prospective study. It included 29 individuals of both genders with severe or profound sensorineural hearing loss without other type of disorders, aged 11 to 42 years; all were assessed by behavioral audiological evaluation and auditory evoked potentials.RESULTS: A recording of the P3 wave was obtained in 17 individuals, with a mean latency of 326.97 ms and mean amplitude of 3.76 V. There were significant differences in latency in relation to age and in amplitude according to degree of hearing loss. There was a statistically significant association of the P300 results with the degrees of hearing loss (p = 0.04, with the predominant auditory communication channels (p < 0.0001, and with time of hearing loss.CONCLUSIONS: P300 can be recorded in individuals with severe and profound congenital sensorineural hearing loss; it may contribute to the understanding of cortical development and is a good predictor of the early intervention outcome.

  11. P300 in individuals with sensorineural hearing loss.

    Science.gov (United States)

    Reis, Ana Cláudia Mirandola Barbosa; Frizzo, Ana Claudia Figueiredo; Isaac, Myriam de Lima; Garcia, Cristiane Fregonesi Dutra; Funayama, Carolina Araújo Rodrigues; Iório, Maria Cecília Martinelli

    2015-01-01

    Behavioral and electrophysiological auditory evaluations contribute to the understanding of the auditory system and of the process of intervention. To study P300 in subjects with severe or profound sensorineural hearing loss. This was a descriptive cross-sectional prospective study. It included 29 individuals of both genders with severe or profound sensorineural hearing loss without other type of disorders, aged 11 to 42 years; all were assessed by behavioral audiological evaluation and auditory evoked potentials. A recording of the P3 wave was obtained in 17 individuals, with a mean latency of 326.97ms and mean amplitude of 3.76V. There were significant differences in latency in relation to age and in amplitude according to degree of hearing loss. There was a statistically significant association of the P300 results with the degrees of hearing loss (p=0.04), with the predominant auditory communication channels (p<0.0001), and with time of hearing loss. P300 can be recorded in individuals with severe and profound congenital sensorineural hearing loss; it may contribute to the understanding of cortical development and is a good predictor of the early intervention outcome. Copyright © 2014 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.

  12. Slow movement execution in event-related potentials (P300).

    Science.gov (United States)

    Naruse, Kumi; Sakuma, Haruo; Hirai, Takane

    2002-02-01

    We examined whether slow movement execution has an effect on cognitive and information processing by measuring the P300 component. 8 subjects performed a continuous slow forearm rotational movement using 2 task speeds. Slow (a 30-50% decrease from the subject's Preferred speed) and Very Slow (a 60-80% decrease). The mean coefficient of variation for rotation speed under Very Slow was higher than that under Slow, showing that the subjects found it difficult to perform the Very Slow task smoothly. The EEG score of alpha-1 (8-10 Hz) under Slow Condition was increased significantly more than under the Preferred Condition; however, the increase under Very Slow was small when compared with Preferred. After performing the task. P300 latency under Very Slow increased significantly as compared to that at pretask. Further, P300 amplitude decreased tinder both speed conditions when compared to that at pretask, and a significant decrease was seen under the Slow Condition at Fz, whereas the decrease under the Very Slow Condition was small. These differences indicated that a more complicated neural composition and an increase in subjects' attention might have been involved when the task was performed under the Very Slow Condition. We concluded that slow movement execution may have an influence on cognitive function and may depend on the percentage of decrease from the Preferred speed of the individual.

  13. A study on the cerebral dominance and the origin of P300 using acoustic P300 and single photon emission computed tomography in normal volunteers

    International Nuclear Information System (INIS)

    Sato, Kenichi

    1994-01-01

    P300 is one of the late positive component of event related potentials. Its latency is around 300 ms following in frequent stimuli. P300 components are evident only in response to the target stimuli and are thought to reflect the speed of stimulus evaluation and categorization. Thus, abnormalities of P300 component may be expected in disorders which are characterised by cognitive slowing. Recently, P300 has been used in the assessment of cognitive function for many diseases such as dementia or cerebrovascular disease. However, the origin of P300 is still unknown. In this study, to investigate the superiority of hemisphere and the origin of P300, P300 assessment and SPECT were performed in normal subjects. An auditory oddball paradigm was used to elicit the P300 components in 40 normal volunteers (15 to 77 years). P300 peak latency and peak-to-peak amplitude of N200 and P300 were measured from Cz (midline), C3 (left side), and C4 (right side) using the International 10-20 System. 123 I-IMP-SPECT was studied in 7 normal volunteers (26 to 56 years) in conjunction with auditory P300 stimulation. Right-Left ratios of count rates of both hemispheres and ROI (region of interest) setting in frontal lobe, temporal lobe, basal ganglia, and cerebellum were calculated, and the following results were obtained. P300 latency was significantly decreased in Cz and C4 compared with C3. P300 amplitude was significantly increased in Cz and C4 compared with C3. Cerebral blood flow increase in the right hemisphere was observed in 5 of the 7 subjects that underwent auditory P300 stimulation. Right-Left ratio of count rates showed over 1 in the temporal lobe and basal ganglia. The above results suggested that auditory P300 showed right hemisphere superiority, and that the temporal lobe and basal ganglia may be especially important to the origin of P300. (author)

  14. Acute caffeine effect on repeatedly measured P300

    OpenAIRE

    Pan, Jingbo; Takeshita, Tatsuya; Morimoto, Kanehisa

    2000-01-01

    The acute effect of a single-dose of caffeine on the P300 event-related brain potential (ERP) was assessed in a study using a repeatedly presented auditory oddball button-press task. A dose (5mg/kg body-weight) of either caffeine or placebo lactose, dissolved in a cup of decaffeinated coffee, was administered double-blindly to coffee drinkers who had abstained from coffee for 24hrs, with the presentation order of the sessions counterbalanced and separated by 2–4 weeks. The caffeine-treatment ...

  15. Phosphorylation of p300 by ATM controls the stability of NBS1

    International Nuclear Information System (INIS)

    Jang, Eun Ryoung; Choi, Jae Duk; Jeong, Gajin; Lee, Jong-Soo

    2010-01-01

    Acetyltransferase, p300 is a transcriptional cofactor of signal-responsive transcriptional regulation. The surveillance kinase ataxia-telangiectasia mutated (ATM) plays a central role in regulation of a wide range of cellular DNA damage responses. Here, we investigated whether and how ATM mediates phosphorylation of p300 in response to DNA damage and how p300 phosphorylation is functionally linked to DNA damage. ATM-phosphorylated p300 in vitro and in vivo, in response to DNA damage. Phosphorylation of p300 proteins was observed upon γ-irradiation in ATM + cells but not ATM - cells. Importantly, expression of nonphosphorylatable serine to alanine form of p300 (S106A) destabilized both p300 and NBS1 proteins, after DNA damage. These data demonstrate that ATM transduces a DNA damage signal to p300, and that ATM-dependent phosphorylation of p300 is required for stabilization of NBS1 proteins in response to DNA damage.

  16. Musical rhythms and their influence on P300 velocity in young females Ritmos musicais diferentes: influência da velocidade no P300 em jovens mulheres

    OpenAIRE

    Cintia Ishii de Sá; Liliane Desguado Pereira

    2011-01-01

    Exposure to music may be useful in the P300 retest and avoid habituation. AIM: To verify the influence of the exposure to different kinds of music in P300 in young females. STUDY DESIGN: Clinical prospective. MATERIAL AND METHOD: Forty-five women aged from 20 to 36 years were evaluated. P300 was studied before and after musical stimulation with different rhythms. Brazilian songs, international songs, and classical music melodies were selected. Each song had its velocity altered and was named ...

  17. P300 correlates with learning & memory abilities and fluid intelligence.

    Science.gov (United States)

    Amin, Hafeez Ullah; Malik, Aamir Saeed; Kamel, Nidal; Chooi, Weng-Tink; Hussain, Muhammad

    2015-09-23

    Educational psychology research has linked fluid intelligence with learning and memory abilities and neuroimaging studies have specifically associated fluid intelligence with event related potentials (ERPs). The objective of this study is to find the relationship of ERPs with learning and memory recall and predict the memory recall score using P300 (P3) component. A sample of thirty-four healthy subjects between twenty and thirty years of age was selected to perform three tasks: (1) Raven's Advanced Progressive Matrices (RAPM) test to assess fluid intelligence; (2) learning and memory task to assess learning ability and memory recall; and (3) the visual oddball task to assess brain-evoked potentials. These subjects were divided into High Ability (HA) and Low Ability (LA) groups based on their RAPM scores. A multiple regression analysis was used to predict the learning & memory recall and fluid intelligence using P3 amplitude and latency. Behavioral results demonstrated that the HA group learned and recalled 10.89 % more information than did the LA group. ERP results clearly showed that the P3 amplitude of the HA group was relatively larger than that observed in the LA group for both the central and parietal regions of the cerebrum; particularly during the 300-400 ms time window. In addition, a shorter latency for the P3 component was observed at Pz site for the HA group compared to the LA group. These findings agree with previous educational psychology and neuroimaging studies which reported an association between ERPs and fluid intelligence as well as learning performance. These results also suggest that the P3 component is associated with individual differences in learning and memory recall and further indicate that P3 amplitude might be used as a supporting factor in standard psychometric tests to assess an individual's learning & memory recall ability; particularly in educational institutions to aid in the predictability of academic skills.

  18. Avaliação auditiva central com BERA e P300 na Doença de Parkinson

    Directory of Open Access Journals (Sweden)

    Pineroli José C.A.

    2002-01-01

    Full Text Available Introdução: A Doença de Parkinson (DP é um dos distúrbios do movimento mais encontrados na população idosa. Cursa com perda progressiva e irreversível de células da substância negra (locus niger do mesencéfalo, o que resultará numa diminuição da produção de dopamina, levando à sintomatologia da DP. Objetivo: Averiguar a relevância de testes eletrofisiológicos, capazes de monitorar a integridade funcional das vias cerebrais, no diagnóstico e/ou prognóstico de pacientes com DP, uma vez que tais testes não-invasivos são de fácil aplicabilidade, rápidos e facilmente compreendidos por quem participa de sua aplicação. Forma de estudo: Prospectivo clínico randomizado. Material e Método: Grupo de 32 pacientes com diagnóstico prévio de DP, submetidos aos testes de potencial evocado BERA e P300. Pacientes de ambos os sexos, entre 44 e 85 anos, com tempo de doença variando de 8 meses a 21 anos de evolução. Resultados: os valores do BERA e do P300 encontrados em pacientes com DP não se mostraram diferentes dos limites de normalidade para a idade. Conclusão: Observou-se integridade das vias auditivas em pacientes portadores de DP. Uma vez que a latência do P300 aumenta de forma linear com a idade, a partir dos 45 anos, aceitando-se um aumento de 1 a 1,5ms por ano¹; observou-se integridade nas vias cerebrais que refletem a habilidade de performance cognitiva em pacientes portadores de DP sem comprometimento demencial exuberante.

  19. Neuronal correlates of a virtual-reality-based passive sensory P300 network.

    Science.gov (United States)

    Chen, Chun-Chuan; Syue, Kai-Syun; Li, Kai-Chiun; Yeh, Shih-Ching

    2014-01-01

    P300, a positive event-related potential (ERP) evoked at around 300 ms after stimulus, can be elicited using an active or passive oddball paradigm. Active P300 requires a person's intentional response, whereas passive P300 does not require an intentional response. Passive P300 has been used in incommunicative patients for consciousness detection and brain computer interface. Active and passive P300 differ in amplitude, but not in latency or scalp distribution. However, no study has addressed the mechanism underlying the production of passive P300. In particular, it remains unclear whether the passive P300 shares an identical active P300 generating network architecture when no response is required. This study aims to explore the hierarchical network of passive sensory P300 production using dynamic causal modelling (DCM) for ERP and a novel virtual reality (VR)-based passive oddball paradigm. Moreover, we investigated the causal relationship of this passive P300 network and the changes in connection strength to address the possible functional roles. A classical ERP analysis was performed to verify that the proposed VR-based game can reliably elicit passive P300. The DCM results suggested that the passive and active P300 share the same parietal-frontal neural network for attentional control and, underlying the passive network, the feed-forward modulation is stronger than the feed-back one. The functional role of this forward modulation may indicate the delivery of sensory information, automatic detection of differences, and stimulus-driven attentional processes involved in performing this passive task. To our best knowledge, this is the first study to address the passive P300 network. The results of this study may provide a reference for future clinical studies on addressing the network alternations under pathological states of incommunicative patients. However, caution is required when comparing patients' analytic results with this study. For example, the task

  20. Neuronal correlates of a virtual-reality-based passive sensory P300 network.

    Directory of Open Access Journals (Sweden)

    Chun-Chuan Chen

    Full Text Available P300, a positive event-related potential (ERP evoked at around 300 ms after stimulus, can be elicited using an active or passive oddball paradigm. Active P300 requires a person's intentional response, whereas passive P300 does not require an intentional response. Passive P300 has been used in incommunicative patients for consciousness detection and brain computer interface. Active and passive P300 differ in amplitude, but not in latency or scalp distribution. However, no study has addressed the mechanism underlying the production of passive P300. In particular, it remains unclear whether the passive P300 shares an identical active P300 generating network architecture when no response is required. This study aims to explore the hierarchical network of passive sensory P300 production using dynamic causal modelling (DCM for ERP and a novel virtual reality (VR-based passive oddball paradigm. Moreover, we investigated the causal relationship of this passive P300 network and the changes in connection strength to address the possible functional roles. A classical ERP analysis was performed to verify that the proposed VR-based game can reliably elicit passive P300. The DCM results suggested that the passive and active P300 share the same parietal-frontal neural network for attentional control and, underlying the passive network, the feed-forward modulation is stronger than the feed-back one. The functional role of this forward modulation may indicate the delivery of sensory information, automatic detection of differences, and stimulus-driven attentional processes involved in performing this passive task. To our best knowledge, this is the first study to address the passive P300 network. The results of this study may provide a reference for future clinical studies on addressing the network alternations under pathological states of incommunicative patients. However, caution is required when comparing patients' analytic results with this study. For example

  1. Evoked potentials N200/P300 disorders and clinical phenotype in Cuban families with paranoid schizophrenia: a family-based association study

    Directory of Open Access Journals (Sweden)

    Seidel Guerra López

    2015-04-01

    Full Text Available INTRODUCCIÓN Los potenciales relacionados a eventos N200 y P300 son herramientas sensibles para evaluar el funcionamiento sensorial y cognitivo. Debido a que, frecuentemente se reporta una prolongación de la latencia y una disminución de la amplitud de los componentes N200 y P300 en pacientes con esquizofrenia, estos potenciales constituyen marcadores biológicos de vulnerabilidad genética para este trastorno mental. OBJETIVO Precisar la asociación de las alteraciones en la latencia, la amplitud y la distribución topográfica de los potenciales N200 y P300 de pacientes con esquizofrenia paranoide y sus familiares sanos de primer grado, pertenecientes a familias con esquizofrenia multiplex. MÉTODOS Se utilizó un paradigma “odd-ball” auditivo para evaluar la latencia, la amplitud y la distribución topográfica de los componentes N200 y P300 en 25 pacientes con esquizofrenia paranoide (probandos, 23 familiares sanos de primer grado y 25 sujetos controles, mediante un estudio de asociación familiar en 60 familias afectadas con esquizofrenia multiplex. RESULTADOS Los probandos y sus familiares mostraron una prolongación significativa de la latencia y una disminución de amplitud de las ondas N200 y P300 cuando se compararon con los sujetos sanos. De igual forma, la amplitud de los potenciales N200 y P300 resultó significativamente disminuida en regiones temporales del hemisferio izquierdo de los probandos y sus familiares con respecto al grupo control. CONCLUSIONES En concordancia con resultados de otros investigadores, este estudio sugiere que, la prolongación de latencia, la disminución de amplitud y las alteraciones en la distribución topográficas detectadas en regiones temporales de los potenciales N200 y P300, pueden constituir por su elevada asociación familiar, marcadores de rasgo para la esquizofrenia paranoide.

  2. The P300 in middle cerebral artery strokes or hemorrhages: Outcome predictions and source localization.

    Science.gov (United States)

    Ehlers, Mana R; López Herrero, Carmen; Kastrup, Andreas; Hildebrandt, Helmut

    2015-08-01

    There are no reliable outcome predictors for severely impaired patients suffering from large infarctions or hemorrhages within the territory of the middle cerebral artery. This study investigated whether the amplitude of the event-related potential (ERP) component P300 predicts if a patient will be transferred to the next stage of rehabilitation (positive outcome) or to a nursing home (negative outcome). The second goal was to look for lesion locations determining the generation of the P300 amplitude. Forty-seven patients performed an auditory oddball task to elicit the P300 and were assessed with different scores for activities of daily living (ADL). Patients were divided in two groups according to their outcome. P300 amplitudes were compared between these groups controlling for age and gender. Post-hoc analyses were performed to analyse the relationship between P300 amplitude and neurological outcome scores. In addition, lesion overlaps were created to detect which lesion pattern affects P300 generation. Patients with a positive outcome showed higher P300 amplitudes at frontal electrode sites than those with a negative outcome. P300 amplitude correlated with ADL score difference. Lesions in the superior temporal gyrus, middle and inferior frontal and prefrontal regions led to visibly diminished P300 amplitudes. The findings suggest that an impairment of attention (P300 amplitude reduction) negatively influences successful neurological rehabilitation. Left superior temporal lobe and the left premotor/prefrontal areas are essential brain areas for the generation of the P300. P300 amplitude may be used as an outcome predictor for severely impaired patients suffering from middle cerebral artery strokes or hemorrhages. Copyright © 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

  3. Musical rhythms and their influence on P300 velocity in young females

    OpenAIRE

    Sá, Cintia Ishii de; Pereira, Liliane Desguado

    2011-01-01

    Exposure to music may be useful in the P300 retest and avoid habituation. AIM: To verify the influence of the exposure to different kinds of music in P300 in young females. STUDY DESIGN: Clinical prospective. MATERIAL AND METHOD: Forty-five women aged from 20 to 36 years were evaluated. P300 was studied before and after musical stimulation with different rhythms. Brazilian songs, international songs, and classical music melodies were selected. Each song had its velocity altered and was named ...

  4. Cinnamoyl compounds as simple molecules that inhibit p300 histone acetyltransferase.

    Science.gov (United States)

    Costi, Roberta; Di Santo, Roberto; Artico, Marino; Miele, Gaetano; Valentini, Paola; Novellino, Ettore; Cereseto, Anna

    2007-04-19

    Cinnamoly compounds 1a-c and 2a-d were designed, synthesized, and in vitro tested as p300 inhibitors. At different degrees, all tested compounds were proven to inactivate p300, particularly, derivative 2c was the most active inhibitor, also showing high specificity for p300 as compared to other histone acetyltransferases. Most notably, 2c showed anti-acetylase activity in mammalian cells. These compounds represent a new class of synthetic inhibitors of p300, characterized by simple chemical structures.

  5. An Asynchronous P300 BCI With SSVEP-Based Control State Detection

    DEFF Research Database (Denmark)

    Panicker, Rajesh C.; Puthusserypady, Sadasivan; Sun, Ying

    2011-01-01

    In this paper, an asynchronous brain–computer interface (BCI) system combining the P300 and steady-state visually evoked potentials (SSVEPs) paradigms is proposed. The information transfer is accomplished using P300 event-related potential paradigm and the control state (CS) detection is achieved...

  6. Stability of genetic and environmental influences om P300 amplitude: a longitudinal study in adolescent twins

    NARCIS (Netherlands)

    van Beijsterveldt, C.E.M.; van Baal, G.C.M.; Molenaar, P.C.M.; Boomsma, D.I.; de Geus, E.J.C.

    2001-01-01

    This study examined the stability of genetic and environmental influences on individual differences in P300 amplitude during adolescence. The P300 component is an event-related brain potential (ERP) that has attracted much attention as a biological marker for disturbed cognitive processing in

  7. Stability of genetic and environmental influences on P300 amplitude: A longitudinal study in adolescent twins.

    NARCIS (Netherlands)

    van Beijsterveldt, C.E.; van Baal, G.C.; Molenaar, P.C.M.; Boomsma, D.I.; Geus, E.J.

    2001-01-01

    Examined the stability of genetic and environmental influences on individual differences in P300 amplitude during adolescence. The P300 component is an event-related brain potential (ERP) that has attracted much attention as a biological marker for disturbed cognitive processing in psychopathology.

  8. P300 component of event-related potentials in persons with asperger disorder.

    Science.gov (United States)

    Iwanami, Akira; Okajima, Yuka; Ota, Haruhisa; Tani, Masayuki; Yamada, Takashi; Yamagata, Bun; Hashimoto, Ryuichiro; Kanai, Chieko; Takashio, Osamu; Inamoto, Atsuko; Ono, Taisei; Takayama, Yukiko; Kato, Nobumasa

    2014-10-01

    In the present study, we investigated auditory event-related potentials in adults with Asperger disorder and normal controls using an auditory oddball task and a novelty oddball task. Task performance and the latencies of P300 evoked by both target and novel stimuli in the two tasks did not differ between the two groups. Analysis of variance revealed that there was a significant interaction effect between group and electrode site on the mean amplitude of the P300 evoked by novel stimuli, which indicated that there was an altered distribution of the P300 in persons with Asperger disorder. In contrast, there was no significant interaction effect on the mean P300 amplitude elicited by target stimuli. Considering that P300 comprises two main subcomponents, frontal-central-dominant P3a and parietal-dominant P3b, our results suggested that persons with Asperger disorder have enhanced amplitude of P3a, which indicated activated prefrontal function in this task.

  9. A new hybrid BCI paradigm based on P300 and SSVEP.

    Science.gov (United States)

    Wang, Minjue; Daly, Ian; Allison, Brendan Z; Jin, Jing; Zhang, Yu; Chen, Lanlan; Wang, Xingyu

    2015-04-15

    P300 and steady-state visual evoked potential (SSVEP) approaches have been widely used for brain-computer interface (BCI) systems. However, neither of these approaches can work for all subjects. Some groups have reported that a hybrid BCI that combines two or more approaches might provide BCI functionality to more users. Hybrid P300/SSVEP BCIs have only recently been developed and validated, and very few avenues to improve performance have been explored. The present study compares an established hybrid P300/SSVEP BCIs paradigm to a new paradigm in which shape changing, instead of color changing, is adopted for P300 evocation to decrease the degradation on SSVEP strength. The result shows that the new hybrid paradigm presented in this paper yields much better performance than the normal hybrid paradigm. A performance increase of nearly 20% in SSVEP classification is achieved using the new hybrid paradigm in comparison with the normal hybrid paradigm. All the paradigms except the normal hybrid paradigm used in this paper obtain 100% accuracy in P300 classification. The new hybrid P300/SSVEP BCIs paradigm in which shape changing, instead of color changing, could obtain as high classification accuracy of SSVEP as the traditional SSVEP paradigm and could obtain as high classification accuracy of P300 as the traditional P300 paradigm. P300 did not interfere with the SSVEP response using the new hybrid paradigm presented in this paper, which was superior to the normal hybrid P300/SSVEP paradigm. Copyright © 2014 Elsevier B.V. All rights reserved.

  10. P300 development across the lifespan: a systematic review and meta-analysis.

    Directory of Open Access Journals (Sweden)

    Rik van Dinteren

    Full Text Available BACKGROUND: The P300 component of the event-related potential is a large positive waveform that can be extracted from the ongoing electroencephalogram using a two-stimuli oddball paradigm, and has been associated with cognitive information processing (e.g. memory, attention, executive function. This paper reviews the development of the auditory P300 across the lifespan. METHODOLOGY/PRINCIPAL FINDINGS: A systematic review and meta-analysis on the P300 was performed including 75 studies (n = 2,811. Scopus was searched for studies using healthy subjects and that reported means of P300 latency and amplitude measured at Pz and mean age. These findings were validated in an independent, existing cross-sectional dataset including 1,572 participants from ages 6-87. Curve-fitting procedures were applied to obtain a model of P300 development across the lifespan. In both studies logarithmic Gaussian models fitted the latency and amplitude data best. The P300 latency and amplitude follow a maturational path from childhood to adolescence, resulting in a period that marks a plateau, after which degenerative effects begin. We were able to determine ages that mark a maximum (in P300 amplitude or trough (in P300 latency segregating maturational from degenerative stages. We found these points of deflection occurred at different ages. CONCLUSIONS/SIGNIFICANCE: It is hypothesized that latency and amplitude index different aspects of brain maturation. The P300 latency possibly indexes neural speed or brain efficiency. The P300 amplitude might index neural power or cognitive resources, which increase with maturation.

  11. Análisis cognitivo

    OpenAIRE

    Gómez, Pedro

    2009-01-01

    Transparencias de la presentación sobre análisis cognitivo. Se introducen las nociones de expectativas, limitaciones y oportunidades de aprendizaje. Se desarrolla la noción de capacidad y se presentan ejemplos de la identificación de capacidades relacionadas con un objetivo y de caminos de aprendizaje para un conjunto de tareas.

  12. Use of a Green Familiar Faces Paradigm Improves P300-Speller Brain-Computer Interface Performance.

    Science.gov (United States)

    Li, Qi; Liu, Shuai; Li, Jian; Bai, Ou

    2015-01-01

    A recent study showed improved performance of the P300-speller when the flashing row or column was overlaid with translucent pictures of familiar faces (FF spelling paradigm). However, the performance of the P300-speller is not yet satisfactory due to its low classification accuracy and information transfer rate. To investigate whether P300-speller performance is further improved when the chromatic property and the FF spelling paradigm are combined. We proposed a new spelling paradigm in which the flashing row or column is overlaid with translucent green pictures of familiar faces (GFF spelling paradigm). We analyzed the ERP waveforms elicited by the FF and proposed GFF spelling paradigms and compared P300-speller performance between the two paradigms. Significant differences in the amplitudes of four ERP components (N170, VPP, P300, and P600f) were observed between both spelling paradigms. Compared to the FF spelling paradigm, the GFF spelling paradigm elicited ERP waveforms of higher amplitudes and resulted in improved P300-speller performance. Combining the chromatic property (green color) and the FF spelling paradigm led to better classification accuracy and an increased information transfer rate. These findings demonstrate a promising new approach for improving the performance of the P300-speller.

  13. A covert attention P300-based brain-computer interface: Geospell.

    Science.gov (United States)

    Aloise, Fabio; Aricò, Pietro; Schettini, Francesca; Riccio, Angela; Salinari, Serenella; Mattia, Donatella; Babiloni, Fabio; Cincotti, Febo

    2012-01-01

    The Farwell and Donchin P300 speller interface is one of the most widely used brain-computer interface (BCI) paradigms for writing text. Recent studies have shown that the recognition accuracy of the P300 speller decreases significantly when eye movement is impaired. This report introduces the GeoSpell interface (Geometric Speller), which implements a stimulation framework for a P300-based BCI that has been optimised for operation in covert visual attention. We compared the Geospell with the P300 speller interface under overt attention conditions with regard to effectiveness, efficiency and user satisfaction. Ten healthy subjects participated in the study. The performance of the GeoSpell interface in covert attention was comparable with that of the P300 speller in overt attention. As expected, the effectiveness of the spelling decreased with the new interface in covert attention. The NASA task load index (TLX) for workload assessment did not differ significantly between the two modalities. This study introduces and evaluates a gaze-independent, P300-based brain-computer interface, the efficacy and user satisfaction of which were comparable with those off the classical P300 speller. Despite a decrease in effectiveness due to the use of covert attention, the performance of the GeoSpell far exceeded the threshold of accuracy with regard to effective spelling.

  14. Operation of a P300-based brain-computer interface by patients with spinocerebellar ataxia

    Directory of Open Access Journals (Sweden)

    Yoji Okahara

    Full Text Available Objective: We investigated the efficacy of a P300-based brain-computer interface (BCI for patients with spinocerebellar ataxia (SCA, which is often accompanied by cerebellar impairment. Methods: Eight patients with SCA and eight age- and gender-matched healthy controls were instructed to input Japanese hiragana characters using the P300-based BCI with green/blue flicker. All patients depended on some assistance in their daily lives (modified Rankin scale: mean 3.5. The chief symptom was cerebellar ataxia; no cognitive deterioration was present. A region-based, two-step P300-based BCI was used. During the P300 task, eight-channel EEG data were recorded, and a linear discriminant analysis distinguished the target from other nontarget regions of the matrix. Results: The mean online accuracy in BCI operation was 82.9% for patients with SCA and 83.2% for controls; no significant difference was detected. Conclusion: The P300-based BCI was operated successfully not only by healthy controls but also by individuals with SCA. Significance: These results suggest that the P300-based BCI may be applicable for patients with SCA. Keywords: BCI, BMI, P300, Visual stimuli, Spinocerebellar ataxia

  15. Causality in the association between P300 and alpha event-related desynchronization.

    Directory of Open Access Journals (Sweden)

    Weiwei Peng

    Full Text Available Recent findings indicated that both P300 and alpha event-related desynchronization (α-ERD were associated, and similarly involved in cognitive brain functioning, e.g., attention allocation and memory updating. However, an explicit causal influence between the neural generators of P300 and α-ERD has not yet been investigated. In the present study, using an oddball task paradigm, we assessed the task effect (target vs. non-target on P300 and α-ERD elicited by stimuli of four sensory modalities, i.e., audition, vision, somatosensory, and pain, estimated their respective neural generators, and investigated the information flow among their neural generators using time-varying effective connectivity in the target condition. Across sensory modalities, the scalp topographies of P300 and α-ERD were similar and respectively maximal at parietal and occipital regions in the target condition. Source analysis revealed that P300 and α-ERD were mainly generated from posterior cingulate cortex and occipital lobe respectively. As revealed by time-varying effective connectivity, the cortical information was consistently flowed from α-ERD sources to P300 sources in the target condition for all four sensory modalities. All these findings showed that P300 in the target condition is modulated by the changes of α-ERD, which would be useful to explore neural mechanism of cognitive information processing in the human brain.

  16. Musical rhythms and their influence on P300 velocity in young females.

    Science.gov (United States)

    Sá, Cintia Ishii de; Pereira, Liliane Desguado

    2011-01-01

    Exposure to music may be useful in the P300 retest and avoid habituation. To verify the influence of the exposure to different kinds of music in P300 in young females. Clinical prospective. Forty-five women aged from 20 to 36 years were evaluated. P300 was studied before and after musical stimulation with different rhythms. Brazilian songs, international songs, and classical music melodies were selected. Each song had its velocity altered and was named as fast and slow. Subjects were divided into 2 groups exposed to music: one group was exposed to the fast version and the other to the slow version. The control group not exposed to music and was evaluated within the same time period of the others. There were statistically significant differences when comparing P300 amplitude in the first and third stimulation with the comparison group. In the same subject, several sequential registrations of P300 caused habituation, which was not seen during exposure to music before P300 recording. Exposure to music at preset different velocities did not affect the P300 in young females.

  17. Multifactorial determinants of target and novelty-evoked P300 amplitudes in children of addicted parents.

    Directory of Open Access Journals (Sweden)

    Anja S Euser

    Full Text Available BACKGROUND: Although P300 amplitude reductions constitute a persistent finding in children of addicted parents, relatively little is known about the specificity of this finding. The major aim of this study was to investigate the association between parental rearing, adverse life events, stress-reactivity, substance use and psychopathology on the one hand, and P300 amplitude in response to both target and novel distracter stimuli on the other hand. Moreover, we assessed whether risk group status (i.e., having a parental history of Substance Use Disorders [SUD] uniquely contributed to P300 amplitude variation above and beyond these other variables. METHODS: Event-related potentials were recorded in high-risk adolescents with a parental history of SUD (HR;n=80 and normal-risk controls (NR;n=100 while performing a visual Novelty Oddball paradigm. Stress-evoked cortisol levels were assessed and parenting, life adversities, substance use and psychopathology were examined by using self-reports. RESULTS: HR adolescents displayed smaller P300 amplitudes in response to novel- and to target stimuli than NR controls, while the latter only approached significance. Interestingly, the effect of having a parental history of SUD on target-P300 disappeared when all other variables were taken into account. Externalizing problem behavior was a powerful predictor of target-P300. In contrast, risk group status uniquely predicted novelty-P300 amplitude reductions above and beyond all other factors. CONCLUSION: Overall, the present findings suggest that the P300 amplitude reduction to novel stimuli might be a more specific endophenotype for SUD than the target-P300 amplitude. This pattern of results underscores the importance of conducting multifactorial assessments when examining important cognitive processes in at-risk adolescents.

  18. Connecting the P300 to the diagnosis and prognosis of unconscious patients

    Directory of Open Access Journals (Sweden)

    Ran Li

    2015-01-01

    Full Text Available The residual consciousness of unconscious patients can be detected by studying the P300, a wave among event-related potentials. Previous studies have applied tones, the subject′s name and other names as stimuli. However, the results were not satisfactory. In this study, we changed the constituent order of subjects′two-character names to create derived names. The subject′s derived names, together with tones and their own names, were used as auditory stimuli in event-related potential experiments. Healthy controls and unconscious patients were included in this study and made to listen to these auditory stimuli. In the two paradigms, a sine tone followed by the subject′s own name and the subject′s derived name followed by the subject′s own name were used as standard and deviant stimuli, respectively. The results showed that all healthy controls had the P300 using both paradigms, and that the P300 in the second paradigm had a longer latency and two peaks. All minimally conscious state patients had the P300 in the first paradigm and the majority of them had the P300 in the second paradigm. Most vegetative state patients had no P300. Patients who showed the P300 in the two paradigms had more residual consciousness, and patients with the two-peak P300 had a higher probability of awakening within a short time. Our experimental findings suggest that the P300 event-related potential could reflect the conscious state of unconscious patients.

  19. Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism.

    Science.gov (United States)

    Fu, Maofu; Wang, Chenguang; Rao, Mahadev; Wu, Xiaofang; Bouras, Toula; Zhang, Xueping; Li, Zhiping; Jiao, Xuanmao; Yang, Jianguo; Li, Anping; Perkins, Neil D; Thimmapaya, Bayar; Kung, Andrew L; Munoz, Alberto; Giordano, Antonio; Lisanti, Michael P; Pestell, Richard G

    2005-08-19

    Cyclin D1 encodes a regulatory subunit, which with its cyclin-dependent kinase (Cdk)-binding partner forms a holoenzyme that phosphorylates and inactivates the retinoblastoma protein. In addition to its Cdk binding-dependent functions, cyclin D1 regulates cellular differentiation in part by modifying several transcription factors and nuclear receptors. The molecular mechanism through which cyclin D1 regulates the function of transcription factors involved in cellular differentiation remains to be clarified. The histone acetyltransferase protein p300 is a co-integrator required for regulation of multiple transcription factors. Here we show that cyclin D1 physically interacts with p300 and represses p300 transactivation. We demonstrated further that the interaction of the two proteins occurs at the peroxisome proliferator-activated receptor gamma-responsive element of the lipoprotein lipase promoter in the context of the local chromatin structure. We have mapped the domains in p300 and cyclin D1 involved in this interaction. The bromo domain and cysteine- and histidine-rich domains of p300 were required for repression by cyclin D1. Cyclin D1 repression of p300 was independent of the Cdk- and retinoblastoma protein-binding domains of cyclin D1. Cyclin D1 inhibits histone acetyltransferase activity of p300 in vitro. Microarray analysis identified a signature of genes repressed by cyclin D1 and induced by p300 that promotes cellular differentiation and induces cell cycle arrest. Together, our results suggest that cyclin D1 plays an important role in cellular proliferation and differentiation through regulation of p300.

  20. Performance analysis of a Principal Component Analysis ensemble classifier for Emotiv headset P300 spellers.

    Science.gov (United States)

    Elsawy, Amr S; Eldawlatly, Seif; Taher, Mohamed; Aly, Gamal M

    2014-01-01

    The current trend to use Brain-Computer Interfaces (BCIs) with mobile devices mandates the development of efficient EEG data processing methods. In this paper, we demonstrate the performance of a Principal Component Analysis (PCA) ensemble classifier for P300-based spellers. We recorded EEG data from multiple subjects using the Emotiv neuroheadset in the context of a classical oddball P300 speller paradigm. We compare the performance of the proposed ensemble classifier to the performance of traditional feature extraction and classifier methods. Our results demonstrate the capability of the PCA ensemble classifier to classify P300 data recorded using the Emotiv neuroheadset with an average accuracy of 86.29% on cross-validation data. In addition, offline testing of the recorded data reveals an average classification accuracy of 73.3% that is significantly higher than that achieved using traditional methods. Finally, we demonstrate the effect of the parameters of the P300 speller paradigm on the performance of the method.

  1. Association between auditory P300, psychopathology, and memory function in drug-naïve schizophrenia.

    Science.gov (United States)

    Chang, Wei-Hung; Chen, Kao-Chin; Yang, Yen-Kuang; Chen, Po-See; Lu, Ru-Band; Yeh, Tzung-Lieh; Wang, Carol Sheei-Meei; Lee, I-Hui

    2014-03-01

    The aim of this study was to explore memory deficits and psychopathology and their relationships with P300 in drug-naïve patients with schizophrenia. The Positive and Negative Syndrome Scale (PANSS) and the Wechsler Memory Scale-Revised were administered. Auditory event-related potentials elicited by an oddball paradigm were obtained. After controlling for age, sex, the results showed a statistically significant negative correlation between the total PANSS score and P300 amplitude at the parietal position (r = -0.66, p visual memory was significantly positively correlated with P300 amplitude at the parietal position (r = 0.67, p memory decompensation in P300 among drug-naïve patients with schizophrenia may be considered, and the compensatory or Default Model Network might be a possible explanation of this association. Copyright © 2013. Published by Elsevier B.V.

  2. Sesgos cognitivos y convicciones morales

    Directory of Open Access Journals (Sweden)

    Javier Rodríguez-Ferreiro

    2018-02-01

    Full Text Available La correlación ilusoria o tendencia a sobreestimar la existencia de covariación entre dos eventos se ha propuesto como un facilitador cognitivo para la aparición de prejuicios y estereotipos sociales. Nuestro estudio demuestra que las personas que presentan mayor tendencia a desarrollar correlación ilusoria también tienden a otorgar un alto grado de relevancia a las convicciones morales relacionadas con la lealtad hacia los miembros del propio grupo. Estos resultados ponen de manifiesto la existencia de una estrecha relación entre procesos cognitivos básicos como la correlación ilusoria y complejos fenómenos psicosociales como las preocupaciones morales o la ideología política.

  3. Effects of low-frequency repetitive transcranial magnetic stimulation on event-related potential P300

    Science.gov (United States)

    Torii, Tetsuya; Sato, Aya; Iwahashi, Masakuni; Iramina, Keiji

    2012-04-01

    The present study analyzed the effects of repetitive transcranial magnetic stimulation (rTMS) on brain activity. P300 latency of event-related potential (ERP) was used to evaluate the effects of low-frequency and short-term rTMS by stimulating the supramarginal gyrus (SMG), which is considered to be the related area of P300 origin. In addition, the prolonged stimulation effects on P300 latency were analyzed after applying rTMS. A figure-eight coil was used to stimulate left-right SMG, and intensity of magnetic stimulation was 80% of motor threshold. A total of 100 magnetic pulses were applied for rTMS. The effects of stimulus frequency at 0.5 or 1 Hz were determined. Following rTMS, an odd-ball task was performed and P300 latency of ERP was measured. The odd-ball task was performed at 5, 10, and 15 min post-rTMS. ERP was measured prior to magnetic stimulation as a control. Electroencephalograph (EEG) was measured at Fz, Cz, and Pz that were indicated by the international 10-20 electrode system. Results demonstrated that different effects on P300 latency occurred between 0.5-1 Hz rTMS. With 1 Hz low-frequency magnetic stimulation to the left SMG, P300 latency decreased. Compared to the control, the latency time difference was approximately 15 ms at Cz. This decrease continued for approximately 10 min post-rTMS. In contrast, 0.5 Hz rTMS resulted in delayed P300 latency. Compared to the control, the latency time difference was approximately 20 ms at Fz, and this delayed effect continued for approximately 15 min post-rTMS. Results demonstrated that P300 latency varied according to rTMS frequency. Furthermore, the duration of the effect was not similar for stimulus frequency of low-frequency rTMS.

  4. Cerebral lesions and event-related potential P300 using positron emission tomography (PET)

    International Nuclear Information System (INIS)

    Sakai, Yasujiro; Okamoto, Kazuma; Tanaka, Makoto; Kondoh, Susumu; Hirai, Shunsaku

    1993-01-01

    To determine what lesions are involved in prolonging event-related potential P300 latency, regional cerebral blood flow (rCBF) and metabolism were investigated by positron emission tomography (PET) in a total of 40 patients with neurologic diseases (12 with chronic cerebrovascular disorder, 9 with spino-cerebellar degeneration, 4 with Alzheimer's type dementia, 4 with amyotrophic lateral sclerosis, and 11 with miscellaneous diseases). There was inverse correlation between rCBF and P300 latency in terms of any of the whole, left, and right hemispheres: P300 latency was associated with decreased rCBF. This was more noticeable in the cerebral cortex than white matter and in the right than left hemisphere, although there was no significant difference between them. In none of the regions, however, was there significant correlation between cerebral oxygen consumption and P300 latency. When the right and left frontal, temporal, parietal and occipital cortexes, thalamus, putamen, and caudatum were examined as regions of interest, there was significantly inverse correlation between rCBF and P300 latency in all regions except for the occipital cortex. This was more noticeable on the right than the left side, although no significant difference was observed. Cerebral oxygen consumption in these lesions did not correlate with P300 latency. In the study on bilateral rCBF difference, decreased rCBF confined to the right parietal lobe, bilateral thalamus and bilateral temporal lobes was found to be associated with a significantly prolonged P300 latency. Thus, rCBF in these regions seemed to be particularly responsible for P300 latency. (N.K.)

  5. Cerebral lesions and event-related potential P300 using positron emission tomography (PET)

    Energy Technology Data Exchange (ETDEWEB)

    Sakai, Yasujiro; Okamoto, Kazuma; Tanaka, Makoto; Kondoh, Susumu; Hirai, Shunsaku (Gunma Univ., Maebashi (Japan). School of Medicine)

    1993-06-01

    To determine what lesions are involved in prolonging event-related potential P300 latency, regional cerebral blood flow (rCBF) and metabolism were investigated by positron emission tomography (PET) in a total of 40 patients with neurologic diseases (12 with chronic cerebrovascular disorder, 9 with spino-cerebellar degeneration, 4 with Alzheimer's type dementia, 4 with amyotrophic lateral sclerosis, and 11 with miscellaneous diseases). There was inverse correlation between rCBF and P300 latency in terms of any of the whole, left, and right hemispheres: P300 latency was associated with decreased rCBF. This was more noticeable in the cerebral cortex than white matter and in the right than left hemisphere, although there was no significant difference between them. In none of the regions, however, was there significant correlation between cerebral oxygen consumption and P300 latency. When the right and left frontal, temporal, parietal and occipital cortexes, thalamus, putamen, and caudatum were examined as regions of interest, there was significantly inverse correlation between rCBF and P300 latency in all regions except for the occipital cortex. This was more noticeable on the right than the left side, although no significant difference was observed. Cerebral oxygen consumption in these lesions did not correlate with P300 latency. In the study on bilateral rCBF difference, decreased rCBF confined to the right parietal lobe, bilateral thalamus and bilateral temporal lobes was found to be associated with a significantly prolonged P300 latency. Thus, rCBF in these regions seemed to be particularly responsible for P300 latency. (N.K.).

  6. Quercetin suppresses cyclooxygenase-2 expression and angiogenesis through inactivation of P300 signaling.

    Directory of Open Access Journals (Sweden)

    Xiangsheng Xiao

    Full Text Available Quercetin, a polyphenolic bioflavonoid, possesses multiple pharmacological actions including anti-inflammatory and antitumor properties. However, the precise action mechanisms of quercetin remain unclear. Here, we reported the regulatory actions of quercetin on cyclooxygenase-2 (COX-2, an important mediator in inflammation and tumor promotion, and revealed the underlying mechanisms. Quercetin significantly suppressed COX-2 mRNA and protein expression and prostaglandin (PG E(2 production, as well as COX-2 promoter activation in breast cancer cells. Quercetin also significantly inhibited COX-2-mediated angiogenesis in human endothelial cells in a dose-dependent manner. The in vitro streptavidin-agarose pulldown assay and in vivo chromatin immunoprecipitation assay showed that quercetin considerably inhibited the binding of the transactivators CREB2, C-Jun, C/EBPβ and NF-κB and blocked the recruitment of the coactivator p300 to COX-2 promoter. Moreover, quercetin effectively inhibited p300 histone acetyltransferase (HAT activity, thereby attenuating the p300-mediated acetylation of NF-κB. Treatment of cells with p300 HAT inhibitor roscovitine was as effective as quercetin at inhibiting p300 HAT activity. Addition of quercetin to roscovitine-treated cells did not change the roscovitine-induced inhibition of p300 HAT activity. Conversely, gene delivery of constitutively active p300 significantly reversed the quercetin-mediated inhibition of endogenous HAT activity. These results indicate that quercetin suppresses COX-2 expression by inhibiting the p300 signaling and blocking the binding of multiple transactivators to COX-2 promoter. Our findings therefore reveal a novel mechanism of action of quercetin and suggest a potential use for quercetin in the treatment of COX-2-mediated diseases such as breast cancers.

  7. Escritura inicial y estilo cognitivo

    Directory of Open Access Journals (Sweden)

    Lida Johana Rincon Camacho

    2012-08-01

    Full Text Available Se examinaron los efectos comparados de dos métodos para la enseñanza de la escritura en el nivel inicial: global y silábico y su interacción con el estilo cognitivo en la dimensión de dependencia-independencia de campo (DIC, en 31 niños de dos grupos escolares de primer grado de primaria, de dos instituciones diferentes, en donde cada uno de los métodos de venían implementando. Se aplicaron la prueba CEFT para la determinación del estilo cognitivo y la prueba de escritura “ejercicio de creación de texto” al inicio del año escolar del primer grado y cuatro meses después. Los resultados finales fueron examinados a través de análisis de covarianza en los que se controlaron, como covariables, los logros registrados cuatro meses antes. Los datos muestran evidentes ventajas del método global sobre el método silábico en términos generales, y muy específicamente para los niños de estilo dependiente de campo o intermedio en seis de los ocho los indicadores examinados. Estos resultados son explicados a partir de características distintivas del estilo cognitivo en esta dimensión.

  8. [The P300 based brain-computer interface: effect of stimulus position in a stimulus train].

    Science.gov (United States)

    Ganin, I P; Shishkin, S L; Kochetova, A G; Kaplan, A Ia

    2012-01-01

    The P300 brain-computer interface (BCI) is currently the most efficient BCI. This interface is based on detection of the P300 wave of the brain potentials evoked when a symbol related to the intended input is highlighted. To increase operation speed of the P300 BCI, reduction of the number of stimuli repetitions is needed. This reduction leads to increase of the relative contribution to the input symbol detection from the reaction to the first target stimulus. It is known that the event-related potentials (ERP) to the first stimulus presentations can be different from the ERP to stimuli presented latter. In particular, the amplitude of responses to the first stimulus presentations is often increased, which is beneficial for their recognition by the BCI. However, this effect was not studied within the BCI framework. The current study examined the ERP obtained from healthy participants (n = 14) in the standard P300 BCI paradigm using 10 trials, as well as in the modified P300 BCI with stimuli presented on moving objects in triple-trial (n = 6) and single-trial (n = 6) stimulation modes. Increased ERP amplitude was observed in response to the first target stimuli in both conditions, as well as in the single-trial mode comparing to triple-trial. We discuss the prospects of using the specific features of the ERP to first stimuli and the single-trial ERP for optimizing the high-speed modes in the P300 BCIs.

  9. Dynamic interaction of p220NPAT and CBP/p300 promotes S-phase entry

    International Nuclear Information System (INIS)

    Wang, Aiyan; Ikura, Tsuyoshi; Eto, Kazuhiro; Ota, Masato S.

    2004-01-01

    Cajal bodies contain cyclin E/cdk2 and the substrate p220 NPAT to regulate the transcription of histones, which is essential for cell proliferation, however, recent mouse knockout studies indicate that cyclin E and cdk2 are dispensable for these events. Because the CBP/p300 histone acetyltransferase are also known to be involved in cell proliferation, we examined the molecular and functional interactions of p220 NPAT with the CBP/p300 at the G1/S boundary as cell cycle regulators. The subnuclear localization of p220 NPAT and CBP/p300 proteins showed that their foci partially overlapped in a cell cycle dependent manner. Overexpression of p220 NPAT and CBP/p300 cooperatively enhanced G1/S transition and DNA synthesis even without cdk2 phosphorylation site. Finally, molecular alignment analysis indicated that p220 NPAT contains several potential substrate sites for CBP/p300. Overall, our findings demonstrate that p220 NPAT and CBP/p300 form a transient complex at the G1/S boundary to play cooperative roles to promote the S-phase entry

  10. A P300 event related potential technique for assessment of sexually oriented interest.

    Science.gov (United States)

    Vardi, Yoram; Volos, Michal; Sprecher, Elliot; Granovsky, Yelena; Gruenwald, Ilan; Yarnitsky, David

    2006-12-01

    Despite all of the modern, sophisticated tests that exist for diagnosing and assessing male and female sexual disorders, to our knowledge there is no objective psychophysiological test to evaluate sexual arousal and interest. We provide preliminary data showing a decrease in auditory P300 wave amplitude during exposure to sexually explicit video clips and a significant correlation between the auditory P300 amplitude decrease and self-reported scores of sexual arousal and interest in the clips. A total of 30 healthy subjects were exposed to several blocks of auditory stimuli administered using an oddball paradigm. Baseline auditory P300 amplitudes were obtained and auditory stimuli were then delivered while viewing visual clips with 3 types of content, including sport, scenery and sex. Auditory P300 amplitude significantly decreased during viewing clips of all contents. Viewing sexual content clips caused a maximal decrease in P300 amplitude (p <0.0001). In addition, a high correlation was found between the amplitude decrease and scores on the sexual arousal questionnaire regarding the viewed clips (r = 0.61, p <0.001). In addition, the P300 amplitude decrease was significantly related to the sexual interest score (r = 0.37, p = 0.042) but not to interest in clips of nonsexual content. The change in auditory P300 amplitude during exposure to visual stimuli with sexual context seems to be an objective measure of subject sexual interest. This method might be applied to assess therapeutic intervention and as a diagnostic tool for assessing disorders of impaired libido or psychogenic sexual dysfunction.

  11. ZEB1 Mediates Drug Resistance and EMT in p300-Deficient CRC.

    Science.gov (United States)

    Lazarova, Darina; Bordonaro, Michael

    2017-01-01

    We discuss the hypothesis that ZEB1-Wnt-p300 signaling integrates epithelial to mesenchymal transition (EMT) and resistance to histone deacetylase inhibitors (HDACis) in colorectal cancer (CRC) cells. The HDACi butyrate, derived from dietary fiber, has been linked to CRC prevention, and other HDACis have been proposed as therapeutic agents against CRC. We have previously discussed that resistance to butyrate likely contributes to colonic carcinogenesis, and we have demonstrated that butyrate resistance leads to cross-resistance to cancer therapeutic HDACis. Deregulated Wnt signaling is the major initiating event in most CRC cases. One mechanism whereby butyrate and other HDACis exert their anti-CRC effects is via Wnt signaling hyperactivation, which promotes CRC cell apoptosis. The histone acetylases (HATs) CBP and p300 are mediators of Wnt transcriptional activity, and play divergent roles in the downstream consequences of Wnt signaling. CBP-mediated Wnt signaling is associated with cell proliferation and stem cell maintenance; whereas, p300-mediated Wnt activity is associated with differentiation. We have found that CBP and p300 differentially affect the ability of butyrate to influence Wnt signaling, apoptosis, and proliferation. ZEB 1 is a Wnt signaling-targeted gene, whose product is a transcription factor expressed at the invasive front of carcinomas where it promotes malignant progression and EMT. ZEB1 is typically a transcriptional repressor; however, when associated with p300, ZEB1 enhances transcription. These changes in ZEB1 activity likely affect the cancer cell phenotype. ZEB1 has been shown to promote resistance to chemotherapeutic agents, and expression of ZEB1 is upregulated in butyrate-resistant CRC cells that lack p300 expression. Since the expression of ZEB1 correlates with poor outcomes in cancer, ZEB represents a relevant therapeutic target. Here we propose that targeting the signaling network established by ZEB1, Wnt signaling, and p300

  12. A P300 brain-computer interface based on a modification of the mismatch negativity paradigm.

    Science.gov (United States)

    Jin, Jing; Sellers, Eric W; Zhou, Sijie; Zhang, Yu; Wang, Xingyu; Cichocki, Andrzej

    2015-05-01

    The P300-based brain-computer interface (BCI) is an extension of the oddball paradigm, and can facilitate communication for people with severe neuromuscular disorders. It has been shown that, in addition to the P300, other event-related potential (ERP) components have been shown to contribute to successful operation of the P300 BCI. Incorporating these components into the classification algorithm can improve the classification accuracy and information transfer rate (ITR). In this paper, a single character presentation paradigm was compared to a presentation paradigm that is based on the visual mismatch negativity. The mismatch negativity paradigm showed significantly higher classification accuracy and ITRs than a single character presentation paradigm. In addition, the mismatch paradigm elicited larger N200 and N400 components than the single character paradigm. The components elicited by the presentation method were consistent with what would be expected from a mismatch paradigm and a typical P300 was also observed. The results show that increasing the signal-to-noise ratio by increasing the amplitude of ERP components can significantly improve BCI speed and accuracy. The mismatch presentation paradigm may be considered a viable option to the traditional P300 BCI paradigm.

  13. [The P300-based brain-computer interface: presentation of the complex "flash + movement" stimuli].

    Science.gov (United States)

    Ganin, I P; Kaplan, A Ia

    2014-01-01

    The P300 based brain-computer interface requires the detection of P300 wave of brain event-related potentials. Most of its users learn the BCI control in several minutes and after the short classifier training they can type a text on the computer screen or assemble an image of separate fragments in simple BCI-based video games. Nevertheless, insufficient attractiveness for users and conservative stimuli organization in this BCI may restrict its integration into real information processes control. At the same time initial movement of object (motion-onset stimuli) may be an independent factor that induces P300 wave. In current work we checked the hypothesis that complex "flash + movement" stimuli together with drastic and compact stimuli organization on the computer screen may be much more attractive for user while operating in P300 BCI. In 20 subjects research we showed the effectiveness of our interface. Both accuracy and P300 amplitude were higher for flashing stimuli and complex "flash + movement" stimuli compared to motion-onset stimuli. N200 amplitude was maximal for flashing stimuli, while for "flash + movement" stimuli and motion-onset stimuli it was only a half of it. Similar BCI with complex stimuli may be embedded into compact control systems requiring high level of user attention under impact of negative external effects obstructing the BCI control.

  14. Association between auditory P300, psychopathology, and memory function in drug-naïve schizophrenia

    Directory of Open Access Journals (Sweden)

    Wei-Hung Chang

    2014-03-01

    Full Text Available The aim of this study was to explore memory deficits and psychopathology and their relationships with P300 in drug-naïve patients with schizophrenia. The Positive and Negative Syndrome Scale (PANSS and the Wechsler Memory Scale—Revised were administered. Auditory event-related potentials elicited by an oddball paradigm were obtained. After controlling for age, sex, the results showed a statistically significant negative correlation between the total PANSS score and P300 amplitude at the parietal position (r = −0.66, p < 0.05. Moreover, visual memory was significantly positively correlated with P300 amplitude at the parietal position (r = 0.67, p < 0.05. After controlling for the duration of illness, the above correlations remained statistically significant. The correlation between P300 and the severity of psychopathology was reconfirmed in drug-naïve patients with schizophrenia. A possible contribution of memory decompensation in P300 among drug-naïve patients with schizophrenia may be considered, and the compensatory or Default Model Network might be a possible explanation of this association.

  15. Dimensiones cognitivo-motivacionales y aprendizaje autorregulado

    OpenAIRE

    Valle Arias, Antonio; González Cabanach, Ramón; Barca Lozano, Alfonso; Núñez Pérez, José Carlos

    1996-01-01

    El artículo analiza el aprendizaje escolar donde una perspectiva cognitivo- motivacional, en la que se destacan una serie de ideas relevantes de profundizar en la comprensión de los factores cognitivo-motivacionales que inciden en el aprendizaje escolar.

  16. Dimensiones cognitivo-motivacionales y aprendizaje autorregulado

    Directory of Open Access Journals (Sweden)

    Antonio Valle Arias

    1996-06-01

    Full Text Available El artículo analiza el aprendizaje escolar donde una perspectiva cognitivo- motivacional, en la que se destacan una serie de ideas relevantes de profundizar en la comprensión de los factores cognitivo-motivacionales que inciden en el aprendizaje escolar.

  17. The Performance of EEG-P300 Classification using Backpropagation Neural Networks

    Directory of Open Access Journals (Sweden)

    Arjon Turnip

    2013-12-01

    Full Text Available Electroencephalogram (EEG recordings signal provide an important function of brain-computer communication, but the accuracy of their classification is very limited in unforeseeable signal variations relating to artifacts. In this paper, we propose a classification method entailing time-series EEG-P300 signals using backpropagation neural networks to predict the qualitative properties of a subject’s mental tasks by extracting useful information from the highly multivariate non-invasive recordings of brain activity. To test the improvement in the EEG-P300 classification performance (i.e., classification accuracy and transfer rate with the proposed method, comparative experiments were conducted using Bayesian Linear Discriminant Analysis (BLDA. Finally, the result of the experiment showed that the average of the classification accuracy was 97% and the maximum improvement of the average transfer rate is 42.4%, indicating the considerable potential of the using of EEG-P300 for the continuous classification of mental tasks.

  18. Fusion of P300 and eye-tracker data for spelling using BCI2000

    Science.gov (United States)

    Kalika, Dmitry; Collins, Leslie; Caves, Kevin; Throckmorton, Chandra

    2017-10-01

    Objective. Various augmentative and alternative communication (AAC) devices have been developed in order to aid communication for individuals with communication disorders. Recently, there has been interest in combining EEG data and eye-gaze data with the goal of developing a hybrid (or ‘fused’) BCI (hBCI) AAC system. This work explores the effectiveness of a speller that fuses data from an eye-tracker and the P300 speller in order to create a hybrid P300 speller. Approach. This hybrid speller collects both eye-tracking and EEG data in parallel, and the user spells characters on the screen in the same way that they would if they were only using the P300 speller. Online and offline experiments were performed. The online experiments measured the performance of the speller for sixteen non-disabled participants, while the offline simulations were used to assess the robustness of the hybrid system. Main results. Online results showed that for fifteen non-disabled participants, using eye-gaze in a Bayesian framework with EEG data from the P300 speller improved accuracy (0.0163+/- 2.72 , 0.085+/- 0.111 , 0.080+/- 0.106 for estimated, medium and high variance configurations) and reduced the average number of flashes required to spell a character compared to the standard P300 speller that relies solely on EEG data (-53.27+/- 25.87 , -36.15+/- 19.3 , -18.85+/- 12.43 for estimated, medium and high variance configurations). Offline simulations indicate that the system provides more robust performance than a standalone eye gaze system. Significance. The results of this work on non-disabled participants shows the potential efficacy of hybrid P300 and eye-tracker speller. Further validation on the amyotrophic lateral sceloris population is needed to assess the benefit of this hybrid system.

  19. [P300 potential in chldren with psychogenic nonepileptic events and tension headache].

    Science.gov (United States)

    Steczkowska, Małgorzata; Stolarska-Weryńska, Urszula; Fiederer, Krystyna; Kaciński, Marek

    2016-01-01

    Psychotherapy is being used as the primary treatment in nonepileptic psychogenic seizures and tension headaches in children. Children's intelectual functioning is related to certain endogenous neurophysiological parameters. The goal of this study was to establish whether the endogenous potential P300 is different in children with nonepileptic psychogenic events and with tension headaches, and whether it changes under the influence of the cognitive-behavioral psychotherapy. The study included a group of 47 children: 20 with nonepileptic psychogenic seizures (18 girls and 2 boys), aged 11.09-17.11 years, and 27 children with tension headache (25 girls and 2 boys), aged 10.11-17.11 years. The P300 potential was induced using an auditory stimulus. The reaction time, the amount of mistakes and the percentage of attention focus was measured in all children. All children attended 8-10 psychotherapy sessions. The P300 potential was registered before and after the course of therapy, and additionally in both cycles also after a 3 minutes hyperventilation. Medium P300 parameters were closer to normal in the group of children with tension headaches rather than in the group with nonepileptic seizures. The shorter was the reaction time in the first measurement, the higher the attention score and the shorter the reaction time in the second measurement - this was visible in the results of children with nonepileptic seizures, in contrast to children with tension headaches. The use of hyperventilation caused a noticeable extension of the reaction time in the P300 measurement, with other components unchanged (mistake count and percentage of attention focus). The endogenous potential P300 does vary, although on a statistically insignificant level, in groups of children with tension headaches and nonepileptic seizures.

  20. Dimensiones de personalidad y potencial evocado cerebral

    Directory of Open Access Journals (Sweden)

    S. Camposano

    1994-12-01

    Full Text Available La teoría de la personalidad de Eysenck postula 3 dimensiones ortogonales de personalidad: extraversión (E, neuroticismo (N, psicoticismo (P. Formula predicciones conductuales y fisiológicas relacionándolas a la predisposición a ciertos trastornos. La base biológica de las dimensiones E y N se ha evidenciado en diferencias electrofisiológicas. La dimensión P, agregada posteriormente, ha sido más controvertida, postulándose que no es independiente de las dimensiones antes descritas. Con objeto de estudiar las dimensiones de Eysenck, en particular P, en relación a la reactividad sensorial y a procesos de codificación se registró potencial evocado visual (PEV por flash a 3 diferentes intensidades y P300 auditiva en 20 voluntarios sanos (x 28,5; ds 9,4 años. Se midió amplitud peak to peak y latencia de los componentes III, IV-V-VI y VII de PEV y de P300 mediante programa cursor. Hubo correlación positiva entre dimensiones N y P (spearman, r=0,52, entre P y amplitud del PEV (r=0,58 a intensidad alta y negativa entre E y latencia de P300 (r=-0,58. Según nuestros hallazgos, la dimensión P no es independiente y demostró relación con la reactividad sensorial. La dimensión E se relacionó a la velocidad de codificación, apoyando las aseveraciones de Eysenck sobre memoria y aprendizaje.

  1. Transgenic Mice Expressing an Inhibitory Truncated Form of p300 Exhibit Long-Term Memory Deficits

    Science.gov (United States)

    Oliveira, Ana M. M.; Wood, Marcelo A.; McDonough, Conor B.; Abel, Ted

    2007-01-01

    The formation of many forms of long-term memory requires several molecular mechanisms including regulation of gene expression. The mechanisms directing transcription require not only activation of individual transcription factors but also recruitment of transcriptional coactivators. CBP and p300 are transcriptional coactivators that interact with…

  2. Using P300 to Evaluate the Effect of Object Color Knowledge in Novelty Detection

    Directory of Open Access Journals (Sweden)

    Mohammad Amin Khoshlessan1

    2010-05-01

    Full Text Available A B S T R A C T Introduction: In an oddball experiment, the context in which novel stimuli are presented affects characteristics of novelty P3, i.e. as long as there is a difficult task in which the difference between standard and target stimuli is small, recurrent presentation of a highly discrepant stimulus can lead to P300 highly similar to novelty P3. Effect of stimulus properties on P300 has also been previously examined and it has been shown that it plays a significant role in P300 topography, its amplitude and latency.Here we have examined the effect of surface color of objects of high color-diagnosticity in a visual oddball paradigm. Methods: In two separate conditions, we used pictures of fruits as target and novel stimuli. In condition one, novel stimuli were pictures of fruits in their canonical colors. In the second condition, novel stimuli were the same photo filtered to have a different non-canonical color. P300 was compared among these conditions. Results: Both target P3 and novelty P3 were detected in the two conditions but no significant difference was evident between conditions.Discussion: This result suggests that comparing to shape information; color cue does not play a significant role in detecting context novelty.

  3. Effects of training and motivation on auditory P300 brain-computer interface performance.

    Science.gov (United States)

    Baykara, E; Ruf, C A; Fioravanti, C; Käthner, I; Simon, N; Kleih, S C; Kübler, A; Halder, S

    2016-01-01

    Brain-computer interface (BCI) technology aims at helping end-users with severe motor paralysis to communicate with their environment without using the natural output pathways of the brain. For end-users in complete paralysis, loss of gaze control may necessitate non-visual BCI systems. The present study investigated the effect of training on performance with an auditory P300 multi-class speller paradigm. For half of the participants, spatial cues were added to the auditory stimuli to see whether performance can be further optimized. The influence of motivation, mood and workload on performance and P300 component was also examined. In five sessions, 16 healthy participants were instructed to spell several words by attending to animal sounds representing the rows and columns of a 5 × 5 letter matrix. 81% of the participants achieved an average online accuracy of ⩾ 70%. From the first to the fifth session information transfer rates increased from 3.72 bits/min to 5.63 bits/min. Motivation significantly influenced P300 amplitude and online ITR. No significant facilitative effect of spatial cues on performance was observed. Training improves performance in an auditory BCI paradigm. Motivation influences performance and P300 amplitude. The described auditory BCI system may help end-users to communicate independently of gaze control with their environment. Copyright © 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

  4. Motivation modulates the P300 amplitude during brain-computer interface use.

    Science.gov (United States)

    Kleih, S C; Nijboer, F; Halder, S; Kübler, A

    2010-07-01

    This study examined the effect of motivation as a possible psychological influencing variable on P300 amplitude and performance in a brain-computer interface (BCI) controlled by event-related potentials (ERP). Participants were instructed to copy spell a sentence by attending to cells of a randomly flashing 7*7 matrix. Motivation was manipulated by monetary reward. In two experimental groups participants received 25 (N=11) or 50 (N=11) Euro cent for each correctly selected character; the control group (N=11) was not rewarded. BCI performance was defined as the overall percentage of correctly selected characters (correct response rate=CRR). Participants performed at an average of 99%. At electrode location Cz the P300 amplitude was positively correlated to self-rated motivation. The P300 amplitude of the most motivated participants was significantly higher than that of the least motivated participants. Highly motivated participants were able to communicate correctly faster with the ERP-BCI than less motivated participants. Motivation modulates the P300 amplitude in an ERP-BCI. Motivation may contribute to variance in BCI performance and should be monitored in BCI settings. Copyright 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

  5. CRE promoter sites modulate alternative splicing via p300-mediated histone acetylation

    Czech Academy of Sciences Publication Activity Database

    Dušková, E.; Hnilicová, Jarmila; Staněk, D.

    2014-01-01

    Roč. 11, č. 7 (2014), s. 1-10 ISSN 1547-6286 R&D Projects: GA ČR(CZ) GBP305/12/G034 Grant - others:Charles University Prague(CZ) 274111 Institutional support: RVO:61388971 Keywords : alternative splicing * fibronectin * p300 Subject RIV: EE - Microbiology, Virology Impact factor: 4.974, year: 2014

  6. CRE promoter sites modulate alternative splicing via p300-mediated histone acetylation

    Czech Academy of Sciences Publication Activity Database

    Dušková, Eva; Hnilicová, Jarmila; Staněk, David

    2014-01-01

    Roč. 11, č. 7 (2014), s. 865-874 ISSN 1547-6286 R&D Projects: GA ČR(CZ) GBP305/12/G034 Institutional support: RVO:68378050 Keywords : alternative splicing * fibronectin * p300 * histone acetylation * promoter Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 4.974, year: 2014

  7. Effects of ZNF804A on auditory P300 response in schizophrenia.

    LENUS (Irish Health Repository)

    O'Donoghue, T

    2014-01-01

    The common variant rs1344706 within the zinc-finger protein gene ZNF804A has been strongly implicated in schizophrenia (SZ) susceptibility by a series of recent genetic association studies. Although associated with a pattern of altered neural connectivity, evidence that increased risk is mediated by an effect on cognitive deficits associated with the disorder has been equivocal. This study investigated whether the same ZNF804A risk allele was associated with variation in the P300 auditory-evoked response, a cognitively relevant putative endophenotype for SZ. We compared P300 responses in carriers and noncarriers of the ZNF804A risk allele genotype groups in Irish patients and controls (n=97). P300 response was observed to vary according to genotype in this sample, such that risk allele carriers showed relatively higher P300 response compared with noncarriers. This finding accords with behavioural data reported by our group and others. It is also consistent with the idea that ZNF804A may have an impact on cortical efficiency, reflected in the higher levels of activations required to achieve comparable behavioural accuracy on the task used.

  8. Spatial Filter Feature Extraction Methods for P300 BCI Speller: A Comparison

    DEFF Research Database (Denmark)

    Chiou, Eleni; Puthusserypady, Sadasivan

    2017-01-01

    Brain Computer Interface (BCI) systems enable subjects affected by neuromuscular disorders to interact with the outside world. A P300 speller uses Event Related Potential (ERP) components, generated in the brain in the presence of a target stimulus, to extract information about the user’s intent...

  9. Adaptation in P300 braincomputer interfaces: A two-classifier cotraining approach

    DEFF Research Database (Denmark)

    Panicker, Rajesh C.; Sun, Ying; Puthusserypady, Sadasivan

    2010-01-01

    A cotraining-based approach is introduced for constructing high-performance classifiers for P300-based braincomputer interfaces (BCIs), which were trained from very little data. It uses two classifiers: Fishers linear discriminant analysis and Bayesian linear discriminant analysis progressively...

  10. Brain-computer interface using P300 and virtual reality: A gaming approach for treating ADHD

    DEFF Research Database (Denmark)

    Rohani, Darius Adam; Sørensen, Helge Bjarup Dissing; Puthusserypady, Sadasivan

    2014-01-01

    This paper presents a novel brain-computer interface (BCI) system aiming at the rehabilitation of attention-deficit/hyperactive disorder in children. It uses the P300 potential in a series of feedback games to improve the subjects' attention. We applied a support vector machine (SVM) using temporal...

  11. p300/CBP as a Key Nutritional Sensor for Hepatic Energy Homeostasis and Liver Fibrosis

    Directory of Open Access Journals (Sweden)

    Weilei Yao

    2018-01-01

    Full Text Available The overwhelming frequency of metabolic diseases such as obesity and diabetes are closely related to liver diseases, which might share common pathogenic signaling processes. These metabolic disorders in the presence of inflammatory response seem to be triggered by and to reside in the liver, which is the central metabolic organ that plays primary roles in regulating lipid and glucose homeostasis upon alterations of metabolic conditions. Recently, abundant emerging researches suggested that p300 and CREB binding protein (CBP are crucial regulators of energy homeostasis and liver fibrosis through both their acetyltransferase activities and transcriptional coactivators. Plenty of recent findings demonstrated the potential roles of p300/CBP in mammalian metabolic homeostasis in response to nutrients. This review is focused on the different targets and functions of p300/CBP in physiological and pathological processes, including lipogenesis, lipid export, gluconeogenesis, and liver fibrosis, also provided some nutrients as the regulator of p300/CBP for nutritional therapeutic approaches to treat liver diseases.

  12. Activation of Basal Gluconeogenesis by Coactivator p300 Maintains Hepatic Glycogen Storage

    Science.gov (United States)

    Cao, Jia; Meng, Shumei; Ma, Anlin; Radovick, Sally; Wondisford, Fredric E.

    2013-01-01

    Because hepatic glycogenolysis maintains euglycemia during early fasting, proper hepatic glycogen synthesis in the fed/postprandial states is critical. It has been known for decades that gluconeogenesis is essential for hepatic glycogen synthesis; however, the molecular mechanism remains unknown. In this report, we show that depletion of hepatic p300 reduces glycogen synthesis, decreases hepatic glycogen storage, and leads to relative hypoglycemia. We previously reported that insulin suppressed gluconeogenesis by phosphorylating cAMP response element binding protein-binding protein (CBP) at S436 and disassembling the cAMP response element-binding protein-CBP complex. However, p300, which is closely related to CBP, lacks the corresponding S436 phosphorylation site found on CBP. In a phosphorylation-competent p300G422S knock-in mouse model, we found that mutant mice exhibited reduced hepatic glycogen content and produced significantly less glycogen in a tracer incorporation assay in the postprandial state. Our study demonstrates the important and unique role of p300 in glycogen synthesis through maintaining basal gluconeogenesis. PMID:23770612

  13. Training set extension for SVM ensemble in P300-speller with familiar face paradigm.

    Science.gov (United States)

    Li, Qi; Shi, Kaiyang; Gao, Ning; Li, Jian; Bai, Ou

    2018-03-27

    P300-spellers are brain-computer interface (BCI)-based character input systems. Support vector machine (SVM) ensembles are trained with large-scale training sets and used as classifiers in these systems. However, the required large-scale training data necessitate a prolonged collection time for each subject, which results in data collected toward the end of the period being contaminated by the subject's fatigue. This study aimed to develop a method for acquiring more training data based on a collected small training set. A new method was developed in which two corresponding training datasets in two sequences are superposed and averaged to extend the training set. The proposed method was tested offline on a P300-speller with the familiar face paradigm. The SVM ensemble with extended training set achieved 85% classification accuracy for the averaged results of four sequences, and 100% for 11 sequences in the P300-speller. In contrast, the conventional SVM ensemble with non-extended training set achieved only 65% accuracy for four sequences, and 92% for 11 sequences. The SVM ensemble with extended training set achieves higher classification accuracies than the conventional SVM ensemble, which verifies that the proposed method effectively improves the classification performance of BCI P300-spellers, thus enhancing their practicality.

  14. p300 Acetyltransferase Regulates Androgen Receptor Degradation and PTEN-Deficient Prostate Tumorigenesis

    NARCIS (Netherlands)

    Zhong, J.; Ding, L.; Bohrer, L.R.; Pan, Y.; Liu, P.; Zhang, J.; Sebo, T.J.; Karnes, R.J.; Tindall, D.J.; Deursen, J.M. van; Huang, H.

    2014-01-01

    Overexpression of the histone acetyltransferase p300 is implicated in the proliferation and progression of prostate cancer, but evidence of a causal role is lacking. In this study, we provide genetic evidence that this generic transcriptional coactivator functions as a positive modifier of prostate

  15. Individual differences in P300 amplitude: a genetic study in adolescent twins

    NARCIS (Netherlands)

    van Beijsterveldt, C.E.M.; Molenaar, P.C.M.; de Geus, E.J.C.; Boomsma, D.I.

    1998-01-01

    Using quantitative genetic research designs, we decomposed phenotypic variance in P300 parameters into genetic and environmental components. The twin method was used to carry out this decomposition. Event related potentials (ERPs) were measured during a visual oddball paradigm in a sample of 213

  16. Individual differences in P300 amplitude: A genetic study in adolescent twins.

    NARCIS (Netherlands)

    van Beijsterveld, C.E.M.; Molenaar, P.C.M.; de Geus, E.J.C.; Boomsma, D.I.

    1998-01-01

    Using quantitative genetic research designs, we decomposed phenotypic variance in P300 parameters into genetic and environmental components. The twin method was used to carry out this decomposition. Event related potentials (ERPs) were measured during a visual oddball paradigm in a sample of 213

  17. Subregion-Specific p300 Conditional Knock-Out Mice Exhibit Long-Term Memory Impairments

    Science.gov (United States)

    Oliveira, Ana M. M.; Estevez, Marcel A.; Hawk, Joshua D.; Grimes, Shannon; Brindle, Paul K.; Abel, Ted

    2011-01-01

    Histone acetylation plays a critical role during long-term memory formation. Several studies have demonstrated that the histone acetyltransferase (HAT) CBP is required during long-term memory formation, but the involvement of other HAT proteins has not been extensively investigated. The HATs CBP and p300 have at least 400 described interacting…

  18. Superior temporal gyrus volume reduction and P300 in schizophrenia prior to treatment

    International Nuclear Information System (INIS)

    Hirayasu, Akira; Hokama, Hiroto; Ogura, Chikara; Ohta, Hirokazu; Arakaki, Hajime; Asato, Naohiko; Yamaguchi, Keiichiro

    1998-01-01

    Authors measured the superior temporal gyrus volume by 3D MRI imaging for the schizophrenics and simultaneously recorded the P300 component during the auditory odd-ball exercise. Subjects were 8 cases of schizophrenics and the sex- and age-matched healthy control adults. In schizophrenics, the superior temporal gyrus volume reduction was found. When the superior temporal gyrus was divided into two parts, the anterior part containing the primary auditory area, and the posterior part containing the planum temporale and the Wernicle speech area, the volume reduction of left side in the posterior part was remarkable. There was no difference in the latent time and the P300 amplitude between schizophrenics and healthy controls, suggesting that the superior temporal gyrus abnormalities will appear prior to P300 abnormalities. We could not find any correlation between findings of MRI and P300 and psychic symptoms. We discuss the possible contribution on the elucidation of the pathogenesis of the schizophrenia by simultaneous recordings of 3D MRI imaging and the event-related potentials. (K.H.)

  19. Comparative Study of SSVEP- and P300-Based Models for the Telepresence Control of Humanoid Robots.

    Directory of Open Access Journals (Sweden)

    Jing Zhao

    Full Text Available In this paper, we evaluate the control performance of SSVEP (steady-state visual evoked potential- and P300-based models using Cerebot-a mind-controlled humanoid robot platform. Seven subjects with diverse experience participated in experiments concerning the open-loop and closed-loop control of a humanoid robot via brain signals. The visual stimuli of both the SSVEP- and P300- based models were implemented on a LCD computer monitor with a refresh frequency of 60 Hz. Considering the operation safety, we set the classification accuracy of a model over 90.0% as the most important mandatory for the telepresence control of the humanoid robot. The open-loop experiments demonstrated that the SSVEP model with at most four stimulus targets achieved the average accurate rate about 90%, whereas the P300 model with the six or more stimulus targets under five repetitions per trial was able to achieve the accurate rates over 90.0%. Therefore, the four SSVEP stimuli were used to control four types of robot behavior; while the six P300 stimuli were chosen to control six types of robot behavior. Both of the 4-class SSVEP and 6-class P300 models achieved the average success rates of 90.3% and 91.3%, the average response times of 3.65 s and 6.6 s, and the average information transfer rates (ITR of 24.7 bits/min 18.8 bits/min, respectively. The closed-loop experiments addressed the telepresence control of the robot; the objective was to cause the robot to walk along a white lane marked in an office environment using live video feedback. Comparative studies reveal that the SSVEP model yielded faster response to the subject's mental activity with less reliance on channel selection, whereas the P300 model was found to be suitable for more classifiable targets and required less training. To conclude, we discuss the existing SSVEP and P300 models for the control of humanoid robots, including the models proposed in this paper.

  20. Contralateral Noise Stimulation Delays P300 Latency in School-Aged Children.

    Science.gov (United States)

    Ubiali, Thalita; Sanfins, Milaine Dominici; Borges, Leticia Reis; Colella-Santos, Maria Francisca

    2016-01-01

    The auditory cortex modulates auditory afferents through the olivocochlear system, which innervates the outer hair cells and the afferent neurons under the inner hair cells in the cochlea. Most of the studies that investigated the efferent activity in humans focused on evaluating the suppression of the otoacoustic emissions by stimulating the contralateral ear with noise, which assesses the activation of the medial olivocochlear bundle. The neurophysiology and the mechanisms involving efferent activity on higher regions of the auditory pathway, however, are still unknown. Also, the lack of studies investigating the effects of noise on human auditory cortex, especially in peadiatric population, points to the need for recording the late auditory potentials in noise conditions. Assessing the auditory efferents in schoolaged children is highly important due to some of its attributed functions such as selective attention and signal detection in noise, which are important abilities related to the development of language and academic skills. For this reason, the aim of the present study was to evaluate the effects of noise on P300 responses of children with normal hearing. P300 was recorded in 27 children aged from 8 to 14 years with normal hearing in two conditions: with and whitout contralateral white noise stimulation. P300 latencies were significantly longer at the presence of contralateral noise. No significant changes were observed for the amplitude values. Contralateral white noise stimulation delayed P300 latency in a group of school-aged children with normal hearing. These results suggest a possible influence of the medial olivocochlear activation on P300 responses under noise condition.

  1. Contralateral Noise Stimulation Delays P300 Latency in School-Aged Children.

    Directory of Open Access Journals (Sweden)

    Thalita Ubiali

    Full Text Available The auditory cortex modulates auditory afferents through the olivocochlear system, which innervates the outer hair cells and the afferent neurons under the inner hair cells in the cochlea. Most of the studies that investigated the efferent activity in humans focused on evaluating the suppression of the otoacoustic emissions by stimulating the contralateral ear with noise, which assesses the activation of the medial olivocochlear bundle. The neurophysiology and the mechanisms involving efferent activity on higher regions of the auditory pathway, however, are still unknown. Also, the lack of studies investigating the effects of noise on human auditory cortex, especially in peadiatric population, points to the need for recording the late auditory potentials in noise conditions. Assessing the auditory efferents in schoolaged children is highly important due to some of its attributed functions such as selective attention and signal detection in noise, which are important abilities related to the development of language and academic skills. For this reason, the aim of the present study was to evaluate the effects of noise on P300 responses of children with normal hearing.P300 was recorded in 27 children aged from 8 to 14 years with normal hearing in two conditions: with and whitout contralateral white noise stimulation.P300 latencies were significantly longer at the presence of contralateral noise. No significant changes were observed for the amplitude values.Contralateral white noise stimulation delayed P300 latency in a group of school-aged children with normal hearing. These results suggest a possible influence of the medial olivocochlear activation on P300 responses under noise condition.

  2. Autoimmune regulator is acetylated by transcription coactivator CBP/p300

    Energy Technology Data Exchange (ETDEWEB)

    Saare, Mario, E-mail: mario.saare@ut.ee [Molecular Pathology, Institute of General and Molecular Pathology, University of Tartu, 19th Ravila Str, Tartu (Estonia); Rebane, Ana [Molecular Pathology, Institute of General and Molecular Pathology, University of Tartu, 19th Ravila Str, Tartu (Estonia); SIAF, Swiss Institute of Allergy and Asthma Research, University of Zuerich, Davos (Switzerland); Rajashekar, Balaji; Vilo, Jaak [BIIT, Bioinformatics, Algorithmics and Data Mining group, Institute of Computer Science, University of Tartu, Tartu (Estonia); Peterson, Paert [Molecular Pathology, Institute of General and Molecular Pathology, University of Tartu, 19th Ravila Str, Tartu (Estonia)

    2012-08-15

    The Autoimmune Regulator (AIRE) is a regulator of transcription in the thymic medulla, where it controls the expression of a large set of peripheral-tissue specific genes. AIRE interacts with the transcriptional coactivator and acetyltransferase CBP and synergistically cooperates with it in transcriptional activation. Here, we aimed to study a possible role of AIRE acetylation in the modulation of its activity. We found that AIRE is acetylated in tissue culture cells and this acetylation is enhanced by overexpression of CBP and the CBP paralog p300. The acetylated lysines were located within nuclear localization signal and SAND domain. AIRE with mutations that mimicked acetylated K243 and K253 in the SAND domain had reduced transactivation activity and accumulated into fewer and larger nuclear bodies, whereas mutations that mimicked the unacetylated lysines were functionally similar to wild-type AIRE. Analogously to CBP, p300 localized to AIRE-containing nuclear bodies, however, the overexpression of p300 did not enhance the transcriptional activation of AIRE-regulated genes. Further studies showed that overexpression of p300 stabilized the AIRE protein. Interestingly, gene expression profiling revealed that AIRE, with mutations mimicking K243/K253 acetylation in SAND, was able to activate gene expression, although the affected genes were different and the activation level was lower from those regulated by wild-type AIRE. Our results suggest that the AIRE acetylation can influence the selection of AIRE activated genes. -- Highlights: Black-Right-Pointing-Pointer AIRE is acetylated by the acetyltransferases p300 and CBP. Black-Right-Pointing-Pointer Acetylation occurs between CARD and SAND domains and within the SAND domain. Black-Right-Pointing-Pointer Acetylation increases the size of AIRE nuclear dots. Black-Right-Pointing-Pointer Acetylation increases AIRE protein stability. Black-Right-Pointing-Pointer AIRE acetylation mimic regulates a different set of AIRE

  3. Caracterização da normalidade do P300 em adultos jovens Standard characterization of P300 in young adults

    Directory of Open Access Journals (Sweden)

    Cíntia Santos Silva Machado

    2009-01-01

    Full Text Available OBJETIVO: Comparar com a literatura os valores de latência e amplitude de P300 em adultos jovens brasileiros saudáveis a fim de estabelecer um padrão normativo para futuros estudos, e verificar se os valores encontrados na amostra possuem correlação com o sexo, situação proposta na metodologia do exame e fases do ciclo menstrual. MÉTODOS: A amostra constou de 22 indivíduos saudáveis, sem queixa de desatenção, sem problemas neurológicos e auditivos, de 18 a 30 anos de idade. Todos os indivíduos foram submetidos à avaliação audiológica básica a fim de excluir aqueles com perda de audição. As respostas do P300 foram obtidas com equipamento AMPLAID MK22, de dois canais e em ambiente silencioso. RESULTADOS: Os resultados de latência encontrados na amostra, depois de comparados à literatura, enquadraram-se melhor nos intervalos de latência entre 220 e 380 ms. Somente os valores de amplitude foram influenciados pelas variáveis sexo e fase do ciclo menstrual. CONCLUSÃO: Os valores de latência da amostra não sofreram influência da variável sexo, ciclo menstrual e situação, e aproximaram-se com mais fidedignidade aos valores de intervalos de latência entre 220 e 380 ms. Contudo, os intervalos para a amplitude sofreram influência das variáveis sexo e ciclo menstrual, mas não se enquadraram adequadamente aos valores de intervalo encontrados na literatura.PURPOSE: To compare the values of latency and amplitude of P300 of healthy Brazilian young adults with the data available on the literature, in order to establish a normative standard for future studies. In addition, the aim was also to verify if the values found in the sample were correlated to gender, situation proposed in the methodology of the examination, and phase of menstrual cycle. METHODS: The sample consisted of 22 healthy individuals, without any attention complaints, neurological or auditory disorders, and with ages ranging from 18 to 30 years. All subjects

  4. Neuroprotection against vascular dementia after acupuncture combined with donepezil hydrochloride: P300 event related potential

    Directory of Open Access Journals (Sweden)

    Qiang Liu

    2016-01-01

    Full Text Available Acupuncture can be used to treat various nervous system diseases. Here, 168 vascular dementia patients were orally administered donepezil hydrochloride alone (5 mg/day, once a day for 56 days, or combined with acupuncture at Shenting (DU24, Tianzhu (BL10, Sishencong (Extra, Yintang (Extra, Renzhong (DU26, Neiguan (PC6, Shenmen (HT7, Fengchi (GB20, Wangu (GB12 and Baihui (DU20 (once a day for 56 days. Compared with donepezil hydrochloride alone, P300 event related potential latency was shorter with an increased amplitude in patients treated with donepezil hydrochloride and acupuncture. Mini-Mental State Examination score was also higher. Moreover, these differences in P300 latency were identified within different infarcted regions in patients treated with donepezil hydrochloride and acupuncture. These findings indicate that acupuncture combined with donepezil hydrochloride noticeably improves cognitive function in patients with vascular dementia, and exerts neuroprotective effects against vascular dementia.

  5. Towards a truly mobile auditory brain-computer interface: exploring the P300 to take away.

    Science.gov (United States)

    De Vos, Maarten; Gandras, Katharina; Debener, Stefan

    2014-01-01

    In a previous study we presented a low-cost, small, and wireless 14-channel EEG system suitable for field recordings (Debener et al., 2012, psychophysiology). In the present follow-up study we investigated whether a single-trial P300 response can be reliably measured with this system, while subjects freely walk outdoors. Twenty healthy participants performed a three-class auditory oddball task, which included rare target and non-target distractor stimuli presented with equal probabilities of 16%. Data were recorded in a seated (control condition) and in a walking condition, both of which were realized outdoors. A significantly larger P300 event-related potential amplitude was evident for targets compared to distractors (pbrain-computer interface (BCI) study. This leads us to conclude that a truly mobile auditory BCI system is feasible. © 2013.

  6. Brain Mapping of Low and High Implusivity based P300 Signals

    Science.gov (United States)

    Turnip, Arjon; Dwi, Esti K.; Hidayat, Taufik; Hidayat, Teddy

    2018-04-01

    Impulsiveness is defined as action without good planning and with little consideration the consequences. Impulsive actions are typically poorly conceived, prematurely expressed, or inappropriate to the undesirable situation such as abuse of drugs. Instead of taking treatment for an addiction subject, it is better take prevention. In this paper, an implusivity detection based EEG-P300 potential is proposed. Twenty four subjects consist of three groups (addiction, methadone, and control) are involved in the experiment. Five different pictures (one picture related drug is used as a target) were randomly flashed to the subjects. The subject is asked to comfortly sit in a chair and to silently count the appearance number of the target. The high amplitude of the P300 component with shortest latency and dominant brain activity are indicated by high implusive group.

  7. Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

    DEFF Research Database (Denmark)

    Lasko, Loren M; Jakob, Clarissa G; Edalji, Rohinton P

    2017-01-01

    -specific tumour types, including several haematological malignancies and androgen receptor-positive prostate cancer. A-485 inhibited the androgen receptor transcriptional program in both androgen-sensitive and castration-resistant prostate cancer and inhibited tumour growth in a castration-resistant xenograft...... to treat certain cancers, but progress on the development of drug-like histone actyltransferase inhibitors has lagged behind. The histone acetyltransferase paralogues p300 and CREB-binding protein (CBP) are key transcriptional co-activators that are essential for a multitude of cellular processes, and have...... also been implicated in human pathological conditions (including cancer). Current inhibitors of the p300 and CBP histone acetyltransferase domains, including natural products, bi-substrate analogues and the widely used small molecule C646, lack potency or selectivity. Here, we describe A-485, a potent...

  8. Brain-computer interface using P300 and virtual reality: a gaming approach for treating ADHD.

    Science.gov (United States)

    Rohani, Darius Adam; Sorensen, Helge B D; Puthusserypady, Sadasivan

    2014-01-01

    This paper presents a novel brain-computer interface (BCI) system aiming at the rehabilitation of attention-deficit/hyperactive disorder in children. It uses the P300 potential in a series of feedback games to improve the subjects' attention. We applied a support vector machine (SVM) using temporal and template-based features to detect these P300 responses. In an experimental setup using five subjects, an average error below 30% was achieved. To make it more challenging the BCI system has been embedded inside an immersive 3D virtual reality (VR) classroom with simulated distractions, which was created by combining a low-cost infrared camera and an "off-axis perspective projection" algorithm. This system is intended for kids by operating with four electrodes, as well as a non-intrusive VR setting. With the promising results, and considering the simplicity of the scheme, we hope to encourage future studies to adapt the techniques presented in this study.

  9. Cortical activity and children's rituals, habits and other repetitive behavior: a visual P300 study.

    Science.gov (United States)

    Evans, David W; Maliken, Ashley

    2011-10-10

    This study examines the link between children's repetitive, ritualistic, behavior and cortical brain activity. Twelve typically developing children between the ages of 6 and 12 years were administered two visual P300, oddball tasks with a 32-electrode electroencephalogram (EEG) system. One of the oddball tasks was specifically designed to reflect sensitivity to asymmetry, a phenomenon common in children and in a variety of disorders involving compulsive behavior. Parents completed the Childhood Routines Inventory. Children's repetitive, compulsive-like behaviors were strongly associated with faster processing of an asymmetrical target stimulus, even when accounting for their P300 latencies on a control task. The research punctuates the continuity between observed brain-behavior links in clinical disorders such as OCD and autism spectrum disorders, and normative variants of repetitive behavior. Copyright © 2011 Elsevier B.V. All rights reserved.

  10. Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

    Energy Technology Data Exchange (ETDEWEB)

    Lasko, Loren M.; Jakob, Clarissa G.; Edalji, Rohinton P.; Qiu, Wei; Montgomery, Debra; Digiammarino, Enrico L.; Hansen, T. Matt; Risi, Roberto M.; Frey, Robin; Manaves, Vlasios; Shaw, Bailin; Algire, Mikkel; Hessler, Paul; Lam, Lloyd T.; Uziel, Tamar; Faivre, Emily; Ferguson, Debra; Buchanan, Fritz G.; Martin, Ruth L.; Torrent, Maricel; Chiang, Gary G.; Karukurichi, Kannan; Langston, J. William; Weinert, Brian T.; Choudhary, Chunaram; de Vries, Peter; Van Drie, John H.; McElligott, David; Kesicki, Ed; Marmorstein, Ronen; Sun, Chaohong; Cole, Philip A.; Rosenberg, Saul H.; Michaelides, Michael R.; Lai, Albert; Bromberg, Kenneth D. (AbbVie); (UCopenhagen); (Petra Pharma); (UPENN); (JHU); (Van Drie); (Faraday)

    2017-09-27

    The dynamic and reversible acetylation of proteins, catalysed by histone acetyltransferases (HATs) and histone deacetylases (HDACs), is a major epigenetic regulatory mechanism of gene transcription1 and is associated with multiple diseases. Histone deacetylase inhibitors are currently approved to treat certain cancers, but progress on the development of drug-like histone actyltransferase inhibitors has lagged behind2. The histone acetyltransferase paralogues p300 and CREB-binding protein (CBP) are key transcriptional co-activators that are essential for a multitude of cellular processes, and have also been implicated in human pathological conditions (including cancer3). Current inhibitors of the p300 and CBP histone acetyltransferase domains, including natural products4, bi-substrate analogues5 and the widely used small molecule C6466,7, lack potency or selectivity. Here, we describe A-485, a potent, selective and drug-like catalytic inhibitor of p300 and CBP. We present a high resolution (1.95 Å) co-crystal structure of a small molecule bound to the catalytic active site of p300 and demonstrate that A-485 competes with acetyl coenzyme A (acetyl-CoA). A-485 selectively inhibited proliferation in lineage-specific tumour types, including several haematological malignancies and androgen receptor-positive prostate cancer. A-485 inhibited the androgen receptor transcriptional program in both androgen-sensitive and castration-resistant prostate cancer and inhibited tumour growth in a castration-resistant xenograft model. These results demonstrate the feasibility of using small molecule inhibitors to selectively target the catalytic activity of histone acetyltransferases, which may provide effective treatments for transcriptional activator-driven malignancies and diseases.

  11. MindEdit: A P300-based text editor for mobile devices.

    Science.gov (United States)

    Elsawy, Amr S; Eldawlatly, Seif; Taher, Mohamed; Aly, Gamal M

    2017-01-01

    Practical application of Brain-Computer Interfaces (BCIs) requires that the whole BCI system be portable. The mobility of BCI systems involves two aspects: making the electroencephalography (EEG) recording devices portable, and developing software applications with low computational complexity to be able to run on low computational-power devices such as tablets and smartphones. This paper addresses the development of MindEdit; a P300-based text editor for Android-based devices. Given the limited resources of mobile devices and their limited computational power, a novel ensemble classifier is utilized that uses Principal Component Analysis (PCA) features to identify P300 evoked potentials from EEG recordings. PCA computations in the proposed method are channel-based as opposed to concatenating all channels as in traditional feature extraction methods; thus, this method has less computational complexity compared to traditional P300 detection methods. The performance of the method is demonstrated on data recorded from MindEdit on an Android tablet using the Emotiv wireless neuroheadset. Results demonstrate the capability of the introduced PCA ensemble classifier to classify P300 data with maximum average accuracy of 78.37±16.09% for cross-validation data and 77.5±19.69% for online test data using only 10 trials per symbol and a 33-character training dataset. Our analysis indicates that the introduced method outperforms traditional feature extraction methods. For a faster operation of MindEdit, a variable number of trials scheme is introduced that resulted in an online average accuracy of 64.17±19.6% and a maximum bitrate of 6.25bit/min. These results demonstrate the efficacy of using the developed BCI application with mobile devices. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. The Apoptotic Effects of the P300 Activator on Breast Cancer and Lung Fibroblast Cell Lines

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Salahshoor

    2013-10-01

    Full Text Available Background: P300 is an enzyme that acetylates histones during stress. It alsoacetylates several non-histone proteins, including P53 which is the most important tumorsuppressor gene. P53 plays an important role in the apoptosis of tumor cells. Hereby,this study describes the potency of cholera toxin B subunit as a P300 activator to induceapoptosis in a breast cancer cell line (MCF-7 and a lung fibroblast cell line (MRC-5as a non-tumorigenic control sample. Methods: MCF-7 and MRC-5 were cultured in RPMI-1640 and treated with orwithout cholera toxin B subunit at the concentration of 85.43 μmol/L, based on the half-maximal inhibitory concentration index at different times (24, 48 and 72 h. Thepercentage of apoptotic cells was measured by flow cytometry. Real-time quantitativeRT-PCR was performed to estimate the mRNA expression of P300 in MCF-7 and MRC-5 with cholera toxin B subunit at different times. We used the ELISA and Bradford proteintechniques to detect levels of total and acetylated P53 protein generated in MCF-7 andMRC-5. Results: Our findings indicated that the cholera toxin B subunit effectively andsignificantly induced more apoptosis in MCF-7 compared to MRC-5. We showed thatexpression of P300 up-regulated by increasing the time of the cholera toxin B subunittreatment in MCF-7 but not in MRC-5. In addition, the acetylated and total P53protein levels increased more in MCF-7 cells than in MRC-5 cells.Conclusion: Cholera toxin B subunit induced significant cell death in MCF-7, butit could be well tolerated in MRC-5. Therefore, cholera toxin B subunit can besuggested as an anti-cancer agent.

  13. Entrenamiento cognitivo en la esquizofrenia.

    OpenAIRE

    Tomás Martínez, Pilar

    2009-01-01

    RESUMEN La esquizofrenia es un trastorno mental grave que afecta a todas las esferas de la vida de las personas, dificultando su funcionamiento psicosocial. Uno de los objetivos de la rehabilitación psicosocial consiste en favorecer y posibilitar el desarrollo de todo el potencial de la persona, mediante la adquisición o recuperación de la competencia necesaria para el funcionamiento ocupacional adecuado dentro de la comunidad, en términos de normalización y calidad de vida. Y uno de lo...

  14. Autistic Traits Affect P300 Response to Unexpected Events, regardless of Mental State Inferences

    Directory of Open Access Journals (Sweden)

    Mitsuhiko Ishikawa

    2017-01-01

    Full Text Available Limited use of contextual information has been suggested as a way of understanding cognition in people with autism spectrum disorder (ASD. However, it has also been argued that individuals with ASD may have difficulties inferring others’ mental states. Here, we examined how individuals with different levels of autistic traits respond to contextual deviations by measuring event-related potentials that reflect context usage. The Autism Spectrum Quotient (AQ was used to quantify autistic-like traits in 28 university students, and 19 participants were defined as Low or High AQ groups. To additionally examine inferences about mental state, two belief conditions (with or without false belief were included. Participants read short stories in which the final sentence included either an expected or an unexpected word and rated the word’s degree of deviation from expectation. P300 waveform analysis revealed that unexpected words were associated with larger P300 waveforms for the Low AQ group, but smaller P300 responses in the High AQ group. Additionally, AQ social skill subscores were positively correlated with evaluation times in the Unexpected condition, whether a character’s belief was false or not. This suggests that autistic traits can affect responses to unexpected events, possibly because of decreased availability of context information.

  15. The Influence of Negative Emotion on the Simon Effect as Reflected by P300

    Directory of Open Access Journals (Sweden)

    Qingguo Ma

    2013-01-01

    Full Text Available The Simon effect refers to the phenomenon that reaction time (RT is faster when stimulus and response location are congruent than when they are not. This study used the priming-target paradigm to explore the influence of induced negative emotion on the Simon effect with event-related potential techniques (ERPs. The priming stimuli were composed of two kinds of pictures, the negative and neutral pictures, selected from the International Affective Picture System (IAPS. The target stimuli included chessboards of two color types. One was red and black the other one was green and black. Each chessboard was presented on the left or the right of the screen. The participants were asked to press the response keys according to the colors of the chessboards. It was called the congruent condition if the chessboard and the response key were on the same side, otherwise incongruent condition. In this study, the emotion-priming Simon effect was found in terms of RT and P300. Negative emotion compared with neutral emotion significantly enhanced the Simon effect in the cognitive process, reflected by a larger difference of P300 latency between the incongruent and congruent trials. The results suggest that the induced negative emotion influenced the Simon effect at the late stage of the cognitive process, and the P300 latency could be considered as the reference measure. These findings may be beneficial to researches in psychology and industrial engineering in the future.

  16. Object Extraction in Cluttered Environments via a P300-Based IFCE

    Directory of Open Access Journals (Sweden)

    Xiaoqian Mao

    2017-01-01

    Full Text Available One of the fundamental issues for robot navigation is to extract an object of interest from an image. The biggest challenges for extracting objects of interest are how to use a machine to model the objects in which a human is interested and extract them quickly and reliably under varying illumination conditions. This article develops a novel method for segmenting an object of interest in a cluttered environment by combining a P300-based brain computer interface (BCI and an improved fuzzy color extractor (IFCE. The induced P300 potential identifies the corresponding region of interest and obtains the target of interest for the IFCE. The classification results not only represent the human mind but also deliver the associated seed pixel and fuzzy parameters to extract the specific objects in which the human is interested. Then, the IFCE is used to extract the corresponding objects. The results show that the IFCE delivers better performance than the BP network or the traditional FCE. The use of a P300-based IFCE provides a reliable solution for assisting a computer in identifying an object of interest within images taken under varying illumination intensities.

  17. Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity.

    Science.gov (United States)

    Shirakawa, Kotaro; Wang, Lan; Man, Na; Maksimoska, Jasna; Sorum, Alexander W; Lim, Hyung W; Lee, Intelly S; Shimazu, Tadahiro; Newman, John C; Schröder, Sebastian; Ott, Melanie; Marmorstein, Ronen; Meier, Jordan; Nimer, Stephen; Verdin, Eric

    2016-05-31

    Salicylate and acetylsalicylic acid are potent and widely used anti-inflammatory drugs. They are thought to exert their therapeutic effects through multiple mechanisms, including the inhibition of cyclo-oxygenases, modulation of NF-κB activity, and direct activation of AMPK. However, the full spectrum of their activities is incompletely understood. Here we show that salicylate specifically inhibits CBP and p300 lysine acetyltransferase activity in vitro by direct competition with acetyl-Coenzyme A at the catalytic site. We used a chemical structure-similarity search to identify another anti-inflammatory drug, diflunisal, that inhibits p300 more potently than salicylate. At concentrations attainable in human plasma after oral administration, both salicylate and diflunisal blocked the acetylation of lysine residues on histone and non-histone proteins in cells. Finally, we found that diflunisal suppressed the growth of p300-dependent leukemia cell lines expressing AML1-ETO fusion protein in vitro and in vivo. These results highlight a novel epigenetic regulatory mechanism of action for salicylate and derivative drugs.

  18. Targeting an efficient target-to-target interval for P300 speller brain–computer interfaces

    Science.gov (United States)

    Sellers, Eric W.; Wang, Xingyu

    2013-01-01

    Longer target-to-target intervals (TTI) produce greater P300 event-related potential amplitude, which can increase brain–computer interface (BCI) classification accuracy and decrease the number of flashes needed for accurate character classification. However, longer TTIs requires more time for each trial, which will decrease the information transfer rate of BCI. In this paper, a P300 BCI using a 7 × 12 matrix explored new flash patterns (16-, 18- and 21-flash pattern) with different TTIs to assess the effects of TTI on P300 BCI performance. The new flash patterns were designed to minimize TTI, decrease repetition blindness, and examine the temporal relationship between each flash of a given stimulus by placing a minimum of one (16-flash pattern), two (18-flash pattern), or three (21-flash pattern) non-target flashes between each target flashes. Online results showed that the 16-flash pattern yielded the lowest classification accuracy among the three patterns. The results also showed that the 18-flash pattern provides a significantly higher information transfer rate (ITR) than the 21-flash pattern; both patterns provide high ITR and high accuracy for all subjects. PMID:22350331

  19. A p300 and SIRT1 Regulated Acetylation Switch of C/EBPα Controls Mitochondrial Function

    Directory of Open Access Journals (Sweden)

    Mohamad A. Zaini

    2018-01-01

    Full Text Available Summary: Cellular metabolism is a tightly controlled process in which the cell adapts fluxes through metabolic pathways in response to changes in nutrient supply. Among the transcription factors that regulate gene expression and thereby cause changes in cellular metabolism is the basic leucine-zipper (bZIP transcription factor CCAAT/enhancer-binding protein alpha (C/EBPα. Protein lysine acetylation is a key post-translational modification (PTM that integrates cellular metabolic cues with other physiological processes. Here, we show that C/EBPα is acetylated by the lysine acetyl transferase (KAT p300 and deacetylated by the lysine deacetylase (KDAC sirtuin1 (SIRT1. SIRT1 is activated in times of energy demand by high levels of nicotinamide adenine dinucleotide (NAD+ and controls mitochondrial biogenesis and function. A hypoacetylated mutant of C/EBPα induces the transcription of mitochondrial genes and results in increased mitochondrial respiration. Our study identifies C/EBPα as a key mediator of SIRT1-controlled adaption of energy homeostasis to changes in nutrient supply. : Zaini et al. show that the transcription factor C/EBPα is acetylated by p300 and deacetylated by the lysine deacetylase SIRT1. Hypoacetylated C/EBPα induces the transcription of mitochondrial genes and results in increased mitochondrial respiration. C/EBPα is a key mediator of SIRT1-controlled adaption of energy homeostasis to changes in nutrient supply. Keywords: C/EBPα, SIRT1, p300, lysine acetylation, mitochondrial function, cellular metabolism, NAD+, gene regulation

  20. Evaluation of psychoacoustic tests and P300 event-related potentials in elderly patients with hyperhomocysteinemia.

    Science.gov (United States)

    Díaz-Leines, Sergio; Peñaloza-López, Yolanda R; Serrano-Miranda, Tirzo A; Flores-Ávalos, Blanca; Vidal-Ixta, Martha T; Jiménez-Herrera, Blanca

    2013-01-01

    Hyperhomocysteinemia as a risk factor for hearing impairment, neuronal damage and cognitive impairment in elderly patients is controversial and is limited by the small number of studies. The aim of this work was determine if elderly patients detected with hyperhomocysteinemia have an increased risk of developing abnormalities in the central auditory processes as compared with a group of patients with appropriate homocysteine levels, and to define the behaviour of psychoacoustic tests and long latency potentials (P300) in these patients. This was a cross-sectional, comparative and analytical study. We formed a group of patients with hyperhomocysteinemia and a control group with normal levels of homocysteine. All patients underwent audiometry, tympanometry and a selection of psychoacoustic tests (dichotic digits, low-pass filtered words, speech in noise and masking level difference), auditory evoked brainstem potentials and P300. Patients with hyperhomocysteinemia had higher values in the test of masking level difference than did the control group (P=.049) and more protracted latency in P300 (P=.000). Hyperhomocysteinemia is a factor that alters the central auditory functions. Alterations in psychoacoustic tests and disturbances in electrophysiological tests suggest that the central portion of the auditory pathway is affected in patients with hyperhomocysteinemia. Copyright © 2012 Elsevier España, S.L. All rights reserved.

  1. The Human Factors and Ergonomics of P300-Based Brain-Computer Interfaces

    Directory of Open Access Journals (Sweden)

    J. Clark Powers

    2015-08-01

    Full Text Available Individuals with severe neuromuscular impairments face many challenges in communication and manipulation of the environment. Brain-computer interfaces (BCIs show promise in presenting real-world applications that can provide such individuals with the means to interact with the world using only brain waves. Although there has been a growing body of research in recent years, much relates only to technology, and not to technology in use—i.e., real-world assistive technology employed by users. This review examined the literature to highlight studies that implicate the human factors and ergonomics (HFE of P300-based BCIs. We assessed 21 studies on three topics to speak directly to improving the HFE of these systems: (1 alternative signal evocation methods within the oddball paradigm; (2 environmental interventions to improve user performance and satisfaction within the constraints of current BCI systems; and (3 measures and methods of measuring user acceptance. We found that HFE is central to the performance of P300-based BCI systems, although researchers do not often make explicit this connection. Incorporation of measures of user acceptance and rigorous usability evaluations, increased engagement of disabled users as test participants, and greater realism in testing will help progress the advancement of P300-based BCI systems in assistive applications.

  2. A novel task-oriented optimal design for P300-based brain-computer interfaces.

    Science.gov (United States)

    Zhou, Zongtan; Yin, Erwei; Liu, Yang; Jiang, Jun; Hu, Dewen

    2014-10-01

    Objective. The number of items of a P300-based brain-computer interface (BCI) should be adjustable in accordance with the requirements of the specific tasks. To address this issue, we propose a novel task-oriented optimal approach aimed at increasing the performance of general P300 BCIs with different numbers of items. Approach. First, we proposed a stimulus presentation with variable dimensions (VD) paradigm as a generalization of the conventional single-character (SC) and row-column (RC) stimulus paradigms. Furthermore, an embedding design approach was employed for any given number of items. Finally, based on the score-P model of each subject, the VD flash pattern was selected by a linear interpolation approach for a certain task. Main results. The results indicate that the optimal BCI design consistently outperforms the conventional approaches, i.e., the SC and RC paradigms. Specifically, there is significant improvement in the practical information transfer rate for a large number of items. Significance. The results suggest that the proposed optimal approach would provide useful guidance in the practical design of general P300-based BCIs.

  3. Social value orientation modulates the FRN and P300 in the chicken game.

    Science.gov (United States)

    Wang, Yiwen; Kuhlman, D Michael; Roberts, Kathryn; Yuan, Bo; Zhang, Zhen; Zhang, Wei; Simons, Robert F

    2017-07-01

    Social dilemmas pervade daily life, business, and politics. The manners in which these dilemmas are resolved depend in part on the personal characteristics of those involved. One such characteristic is Social Value Orientation (SVO), a trait-like predisposition to maximize cooperative (Pro-Social) or non-cooperative (Pro-Self) outcomes in social relationships. The present study investigated the role of SVO in modulating neural responses to outcomes in a type of social dilemma known as the Chicken Game. The Chicken Game models real-world situations involving two parties independently making a decision between cooperation and aggression. The EEG of Pro-Socials and Pro-Selfs was recorded while playing Chicken with a computer Opponent. Two ERP components were extracted: Feedback-Related Negativity (FRN) and the P300. Despite no behavioral differences in decision (i.e., cooperation, aggression), FRN results indicate that Pro-Socials experienced unreciprocated cooperation as the least desired outcome. Further, P300 results show a main effect for the Opponent's choice, such that the Opponent's cooperation was more salient than aggression. Additionally, an interaction between the Participant's and Opponent's choice showed that the effect for the Opponent's choice only occurred when the Participant chose cooperation. None of the results for P300 were moderated by SVO. For both ERP components, Pro-Selfs showed no differential responding to Chicken outcomes. In addition, FRN magnitude on trial n predicted choice on trial n+1 for Pro-Socials, but not for Pro-Selfs. P300 magnitude on trial n showed no relationship to choice on trial n+1. Results indicate that individual differences in SVO modulate FRN responses to Chicken outcomes, and that these neural reactions may have utility in predicting subsequent behaviors. For P300, there is no evidence of SVO modulation. Our general pattern of FRN responsiveness in Pro-Socials, but not in Pro-Selfs, is related to similar findings in f

  4. Potencial ornamental de Curcuma.

    Directory of Open Access Journals (Sweden)

    Ana Christina Rossini Pinto

    2003-06-01

    Full Text Available A introdução de novas espécies e de novos produtos na indústria da floricultura brasileira é de grande importância para o crescimento do setor, ampliando osortimento de produtos disponíveis, atendendo à necessidade dos produtores e consumidores por novidade, importante componente da estratégia de marketing, desenvolvendo competitividade e estimulando a comercialização, tanto ao nível de mercado interno como externo. O presente artigo discorre sobre o potencial ornamental de espécies do gênero Curcuma L. (Zingiberaceae e apresenta informações referentes à botânica, à produção e à tecnologia de pós-colheita e pós-produção de algumas espécies disponíveis atualmente no mercado internacional de flores e plantas ornamentais, bem como de espécies com potencial de utilização como ornamental. Espera-se, assim, chamar a atenção de pesquisadores e produtores para o potencial do gênero e contribuir para o estabelecimento e desenvolvimento da sua produção no Brasil.

  5. Initial test of a T9-like P300-based speller by an ALS patient

    Science.gov (United States)

    Ron-Angevin, R.; Varona-Moya, S.; da Silva-Sauer, L.

    2015-08-01

    Objective. Visual P300-based brain-computer interface spellers offer a useful communication channel for locked-in patients, who are completely dependent in their daily lives. One of the research goals for these systems is to achieve greater communication rates by means of modifying some features of their interfaces, e.g., reducing the matrix size. However, such modifications may not work well with disabled end-users, such as patients of amyotrophic lateral sclerosis (ALS), due to a supposed reduction of their cognitive resources. The purpose of the present study was to provide a proof of concept that ALS patients could efficiently use a P300-based speller with a 4 × 3 symbol matrix based on the T9 interface developed for mobile phones. Approach. We conducted an experiment with a sample of 11 able-bodied participants and one locked-in patient with ALS. All participants tested our T9-like visual P300-based speller and also two different 7 × 6 matrix spellers based on Farwell and Donchin’s classic proposal—one of them included a word predictor system like the T9-like speller did. Main results. The performance analyses indicated that the locked-in patient benefited from using a reduced matrix size as much as healthy users did, spelling words almost 1.6 times faster and equally accurately when using the T9-like speller than when using the alternative spellers. Significance. Due to counting on only one locked-in patient, the current work constitutes a feasibility study. The actual usability of systems such as the one proposed in this paper should be determined by means of studies with a greater number of end-users in real-life conditions.

  6. Using brain potentials to understand prism adaptation: the error-related negativity and the P300

    Directory of Open Access Journals (Sweden)

    Stephane Joseph Maclean

    2015-06-01

    Full Text Available Prism adaptation (PA is both a perceptual-motor learning task as well as a promising rehabilitation tool for visuo-spatial neglect (VSN – a spatial attention disorder often experienced after stroke resulting in slowed and/or inaccurate motor responses to contralesional targets. During PA, individuals are exposed to prism-induced shifts of the visual-field while performing a visuo-guided reaching task. After adaptation, with goggles removed, visuo-motor responding is shifted to the opposite direction of that initially induced by the prisms. This visuo-motor aftereffect has been used to study visuo-motor learning and adaptation and has been applied clinically to reduce VSN severity by improving motor responding to stimuli in contralesional (usually left-sided space. In order to optimize PA’s use for VSN patients, it is important to elucidate the neural and cognitive processes that alter visuomotor function during PA. In the present study, healthy young adults underwent PA while event-related potentials (ERPs were recorded at the termination of each reach (screen-touch, then binned according to accuracy (hit vs. miss and phase of exposure block (early, middle, late. Results show that two ERP components were evoked by screen-touch: an early error-related negativity (ERN, and a P300. The ERN was consistently evoked on miss trials during adaptation, while the P300 amplitude was largest during the early phase of adaptation for both hit and miss trials. This study provides evidence of two neural signals sensitive to visual feedback during PA that may sub-serve changes in visuomotor responding. Prior ERP research suggests that the ERN reflects an error processing system in medial-frontal cortex, while the P300 is suggested to reflect a system for context updating and learning. Future research is needed to elucidate the role of these ERP components in improving visuomotor responses among individuals with VSN.

  7. Using brain potentials to understand prism adaptation: the error-related negativity and the P300.

    Science.gov (United States)

    MacLean, Stephane J; Hassall, Cameron D; Ishigami, Yoko; Krigolson, Olav E; Eskes, Gail A

    2015-01-01

    Prism adaptation (PA) is both a perceptual-motor learning task as well as a promising rehabilitation tool for visuo-spatial neglect (VSN)-a spatial attention disorder often experienced after stroke resulting in slowed and/or inaccurate motor responses to contralesional targets. During PA, individuals are exposed to prism-induced shifts of the visual-field while performing a visuo-guided reaching task. After adaptation, with goggles removed, visuomotor responding is shifted to the opposite direction of that initially induced by the prisms. This visuomotor aftereffect has been used to study visuomotor learning and adaptation and has been applied clinically to reduce VSN severity by improving motor responding to stimuli in contralesional (usually left-sided) space. In order to optimize PA's use for VSN patients, it is important to elucidate the neural and cognitive processes that alter visuomotor function during PA. In the present study, healthy young adults underwent PA while event-related potentials (ERPs) were recorded at the termination of each reach (screen-touch), then binned according to accuracy (hit vs. miss) and phase of exposure block (early, middle, late). Results show that two ERP components were evoked by screen-touch: an error-related negativity (ERN), and a P300. The ERN was consistently evoked on miss trials during adaptation, while the P300 amplitude was largest during the early phase of adaptation for both hit and miss trials. This study provides evidence of two neural signals sensitive to visual feedback during PA that may sub-serve changes in visuomotor responding. Prior ERP research suggests that the ERN reflects an error processing system in medial-frontal cortex, while the P300 is suggested to reflect a system for context updating and learning. Future research is needed to elucidate the role of these ERP components in improving visuomotor responses among individuals with VSN.

  8. P300 change and cognitive behavioral therapy in subjects with Internet addiction disorder A 3-month follow-up study

    Institute of Scientific and Technical Information of China (English)

    Ling Ge; Xiuchun Ge; Yong Xu; Kerang Zhang; Jing Zhao; Xin Kong

    2011-01-01

    Event-related potential studies of cognitive function in addiction behaviors have focused on the P300 event-related potential component. The current study investigated the association between P300 component and Internet addiction disorder. We found that individuals with Internet addiction disorder exhibited significantly longer P300 latencies than controls (N2: P = 0.035; P3a: P = 0.031; P3b: P = 0.043) and similar P300 amplitudes compared to control participants. After 3 months of cognitive behavioral therapy, P300 latencies decreased significantly in the P3a and P3b (P3a: P = 0.045; P3b: P = 0.062). These results suggest that deficits in cognitive function may be involved in Internet addiction disorder, and that clinical psychological treatment may be effective.

  9. [Research of controlling of smart home system based on P300 brain-computer interface].

    Science.gov (United States)

    Wang, Jinjia; Yang, Chengjie

    2014-08-01

    Using electroencephalogram (EEG) signal to control external devices has always been the research focus in the field of brain-computer interface (BCI). This is especially significant for those disabilities who have lost capacity of movements. In this paper, the P300-based BCI and the microcontroller-based wireless radio frequency (RF) technology are utilized to design a smart home control system, which can be used to control household appliances, lighting system, and security devices directly. Experiment results showed that the system was simple, reliable and easy to be populirised.

  10. Time-Shift Correlation Algorithm for P300 Event Related Potential Brain-Computer Interface Implementation

    Directory of Open Access Journals (Sweden)

    Ju-Chi Liu

    2016-01-01

    Full Text Available A high efficient time-shift correlation algorithm was proposed to deal with the peak time uncertainty of P300 evoked potential for a P300-based brain-computer interface (BCI. The time-shift correlation series data were collected as the input nodes of an artificial neural network (ANN, and the classification of four LED visual stimuli was selected as the output node. Two operating modes, including fast-recognition mode (FM and accuracy-recognition mode (AM, were realized. The proposed BCI system was implemented on an embedded system for commanding an adult-size humanoid robot to evaluate the performance from investigating the ground truth trajectories of the humanoid robot. When the humanoid robot walked in a spacious area, the FM was used to control the robot with a higher information transfer rate (ITR. When the robot walked in a crowded area, the AM was used for high accuracy of recognition to reduce the risk of collision. The experimental results showed that, in 100 trials, the accuracy rate of FM was 87.8% and the average ITR was 52.73 bits/min. In addition, the accuracy rate was improved to 92% for the AM, and the average ITR decreased to 31.27 bits/min. due to strict recognition constraints.

  11. An Asynchronous P300-Based Brain-Computer Interface Web Browser for Severely Disabled People.

    Science.gov (United States)

    Martinez-Cagigal, Victor; Gomez-Pilar, Javier; Alvarez, Daniel; Hornero, Roberto

    2017-08-01

    This paper presents an electroencephalographic (EEG) P300-based brain-computer interface (BCI) Internet browser. The system uses the "odd-ball" row-col paradigm for generating the P300 evoked potentials on the scalp of the user, which are immediately processed and translated into web browser commands. There were previous approaches for controlling a BCI web browser. However, to the best of our knowledge, none of them was focused on an assistive context, failing to test their applications with a suitable number of end users. In addition, all of them were synchronous applications, where it was necessary to introduce a "read-mode" command in order to avoid a continuous command selection. Thus, the aim of this study is twofold: 1) to test our web browser with a population of multiple sclerosis (MS) patients in order to assess the usefulness of our proposal to meet their daily communication needs; and 2) to overcome the aforementioned limitation by adding a threshold that discerns between control and non-control states, allowing the user to calmly read the web page without undesirable selections. The browser was tested with sixteen MS patients and five healthy volunteers. Both quantitative and qualitative metrics were obtained. MS participants reached an average accuracy of 84.14%, whereas 95.75% was achieved by control subjects. Results show that MS patients can successfully control the BCI web browser, improving their personal autonomy.

  12. Synchronized tapping facilitates learning sound sequences as indexed by the P300.

    Science.gov (United States)

    Kamiyama, Keiko S; Okanoya, Kazuo

    2014-01-01

    The purpose of the present study was to determine whether and how single finger tapping in synchrony with sound sequences contributed to the auditory processing of them. The participants learned two unfamiliar sound sequences via different methods. In the tapping condition, they learned an auditory sequence while they tapped in synchrony with each sound onset. In the no tapping condition, they learned another sequence while they kept pressing a key until the sequence ended. After these learning sessions, we presented the two melodies again and recorded event-related potentials (ERPs). During the ERP recordings, 10% of the tones within each melody deviated from the original tones. An analysis of the grand average ERPs showed that deviant stimuli elicited a significant P300 in the tapping but not in the no-tapping condition. In addition, the significance of the P300 effect in the tapping condition increased as the participants showed highly synchronized tapping behavior during the learning sessions. These results indicated that single finger tapping promoted the conscious detection and evaluation of deviants within the learned sequences. The effect was related to individuals' musical ability to coordinate their finger movements along with external auditory events.

  13. Time-Shift Correlation Algorithm for P300 Event Related Potential Brain-Computer Interface Implementation.

    Science.gov (United States)

    Liu, Ju-Chi; Chou, Hung-Chyun; Chen, Chien-Hsiu; Lin, Yi-Tseng; Kuo, Chung-Hsien

    2016-01-01

    A high efficient time-shift correlation algorithm was proposed to deal with the peak time uncertainty of P300 evoked potential for a P300-based brain-computer interface (BCI). The time-shift correlation series data were collected as the input nodes of an artificial neural network (ANN), and the classification of four LED visual stimuli was selected as the output node. Two operating modes, including fast-recognition mode (FM) and accuracy-recognition mode (AM), were realized. The proposed BCI system was implemented on an embedded system for commanding an adult-size humanoid robot to evaluate the performance from investigating the ground truth trajectories of the humanoid robot. When the humanoid robot walked in a spacious area, the FM was used to control the robot with a higher information transfer rate (ITR). When the robot walked in a crowded area, the AM was used for high accuracy of recognition to reduce the risk of collision. The experimental results showed that, in 100 trials, the accuracy rate of FM was 87.8% and the average ITR was 52.73 bits/min. In addition, the accuracy rate was improved to 92% for the AM, and the average ITR decreased to 31.27 bits/min. due to strict recognition constraints.

  14. Aging, physical activity, and cognitive processing: an examination of P300.

    Science.gov (United States)

    McDowell, K; Kerick, S E; Santa Maria, D L; Hatfield, B D

    2003-01-01

    Physical activity appears to attenuate the decline of cognitive function typically observed in older men and women. The P300 component of the event-related potential (ERP) is particularly affected by aging and allows for basic neurobiological assessment of cognitive function. Three aspects of the P300 component (i.e. latency, amplitude, and area under the curve (AUC)), elicited by an oddball task, were derived to assess cognitive function in young and older participants (N=73) who were further classified as high- and low-active. The low-active elderly participants exhibited larger AUC values than those observed in all other groups which were undifferentiated. That is, the high-active elderly and the young participants exhibited smaller AUC values than the low-active older group. In conclusion, higher levels of physical activity in the elderly may be associated with a reduction in the neural resources allocated in response to simple cognitive challenge. This interpretation is consistent with the concept of psychomotor efficiency proposed by Hatfield and Hillman [The psychophysiology of sport: a mechanistic understanding of the psychology of superior performance. In: Singer RN, Hausenbias HA, Janelle CM, editors. Handbook of sport psychology. 2nd ed. New York: Wiley; 2001, p. 362-88].

  15. Affective Stimuli for an Auditory P300 Brain-Computer Interface

    Directory of Open Access Journals (Sweden)

    Akinari Onishi

    2017-09-01

    Full Text Available Gaze-independent brain computer interfaces (BCIs are a potential communication tool for persons with paralysis. This study applies affective auditory stimuli to investigate their effects using a P300 BCI. Fifteen able-bodied participants operated the P300 BCI, with positive and negative affective sounds (PA: a meowing cat sound, NA: a screaming cat sound. Permuted stimuli of the positive and negative affective sounds (permuted-PA, permuted-NA were also used for comparison. Electroencephalography data was collected, and offline classification accuracies were compared. We used a visual analog scale (VAS to measure positive and negative affective feelings in the participants. The mean classification accuracies were 84.7% for PA and 67.3% for permuted-PA, while the VAS scores were 58.5 for PA and −12.1 for permuted-PA. The positive affective stimulus showed significantly higher accuracy and VAS scores than the negative affective stimulus. In contrast, mean classification accuracies were 77.3% for NA and 76.0% for permuted-NA, while the VAS scores were −50.0 for NA and −39.2 for permuted NA, which are not significantly different. We determined that a positive affective stimulus with accompanying positive affective feelings significantly improved BCI accuracy. Additionally, an ALS patient achieved 90% online classification accuracy. These results suggest that affective stimuli may be useful for preparing a practical auditory BCI system for patients with disabilities.

  16. Terapia cognitivo-comportamental da fobia social

    OpenAIRE

    Ito,Lígia M; Roso,Miréia C; Tiwari,Shilpee; Kendall,Philip C; Asbahr,Fernando R

    2008-01-01

    OBJETIVO: Este artigo revisa aspectos relevantes da fobia social e os estágios de tratamento através da terapia cognitivo-comportamental em crianças, adolescentes e adultos. MÉTODO: A partir do banco de dados Medline, realizou-se revisão da literatura publicada a respeito do tratamento da fobia social por meio da terapia cognitivo-comportamental. RESULTADOS: Revisão da literatura sugere que a fobia social é uma condição prevalente e crônica, caracterizada por inibição social e timidez excessi...

  17. Curcumin and its demethoxy derivatives possess p300 HAT inhibitory activity and suppress hypertrophic responses in cardiomyocytes

    Directory of Open Access Journals (Sweden)

    Yoichi Sunagawa

    2018-04-01

    Full Text Available The natural compound, curcumin (CUR, possesses several pharmacological properties, including p300-specific histone acetyltransferase (HAT inhibitory activity. In our previous study, we demonstrated that CUR could prevent the development of cardiac hypertrophy by inhibiting p300-HAT activity. Other major curcuminoids isolated from Curcuma longa including demethoxycurcumin (DMC and bisdemethoxycurcumin (BDMC are structural analogs of CUR. In present study, we first confirmed the effect of these three curcuminoid analogs on p300-HAT activity and cardiomyocyte hypertrophy.Our results showed that DMC and BDMC inhibited p300-HAT activity and cardiomyocyte hypertrophy to almost the same extent as CUR. As the three compounds have structural differences in methoxy groups at the 3-position of their phenol rings, our results suggest that these methoxy groups are not involved in the inhibitory effects on p300-HAT activity and cardiac hypertrophy. These findings provide useful insights into the structure–activity relationship and biological activity of curcuminoids for p300-HAT activity and cardiomyocyte hypertrophy. Keywords: Curcumin, Demethoxycurcumin, Bisdemethoxycurcumin, p300, Cardiomyocyte hypertrophy

  18. EEG correlates of P300-based brain-computer interface (BCI) performance in people with amyotrophic lateral sclerosis

    Science.gov (United States)

    Mak, Joseph N.; McFarland, Dennis J.; Vaughan, Theresa M.; McCane, Lynn M.; Tsui, Phillippa Z.; Zeitlin, Debra J.; Sellers, Eric W.; Wolpaw, Jonathan R.

    2012-04-01

    The purpose of this study was to identify electroencephalography (EEG) features that correlate with P300-based brain-computer interface (P300 BCI) performance in people with amyotrophic lateral sclerosis (ALS). Twenty people with ALS used a P300 BCI spelling application in copy-spelling mode. Three types of EEG features were found to be good predictors of P300 BCI performance: (1) the root-mean-square amplitude and (2) the negative peak amplitude of the event-related potential to target stimuli (target ERP) at Fz, Cz, P3, Pz, and P4; and (3) EEG theta frequency (4.5-8 Hz) power at Fz, Cz, P3, Pz, P4, PO7, PO8 and Oz. A statistical prediction model that used a subset of these features accounted for >60% of the variance in copy-spelling performance (p < 0.001, mean R2 = 0.6175). The correlations reflected between-subject, rather than within-subject, effects. The results enhance understanding of performance differences among P300 BCI users. The predictors found in this study might help in: (1) identifying suitable candidates for long-term P300 BCI operation; (2) assessing performance online. Further work on within-subject effects needs to be done to establish whether P300 BCI user performance could be improved by optimizing one or more of these EEG features.

  19. p300 expression repression by hypermethylation associated with tumour invasion and metastasis in oesophageal squamous cell carcinoma

    Science.gov (United States)

    Zhang, Changsong; Li, Ke; Wei, Lixin; Li, Zhengyou; Yu, Ping; Teng, Lijuan; Wu, Kusheng; Zhu, Jin

    2007-01-01

    Background Aberrant promoter methylation is an important mechanism for gene silencing. Aims To evaluate the promoter methylation status of p300 gene in patients with oesophageal squamous cell carcinoma (OSCC). Methods The methylation status of p300 promoter was analysed by methylation‐specific PCR (MSP) in 50 OSCC tissues and the matching non‐cancerous tissues. Oesophageal cancer cell lines (ECa‐109 and TE‐10) were treated with the demethylation agent 5‐aza‐2′‐deoxycytidine (5‐Aza‐CdR), and p300 mRNA expression was detected by RT‐PCR. Results p300 methylation was found in 42% (21/50) of the OSCC tissues, but in only 20% (10/50) of the corresponding non‐cancerous tissues (p = 0.017). In OSCC samples, 65% of those with deep tumour invasion (adventitia) and 63% samples with metastasis revealed p300 promoter methylation (p<0.05). p300 mRNA expression was observed in 19.0% (4/21) of methylated tumours and 58.6% (17/29) of unmethylated tumours (p = 0.005). In addition, p300 mRNA expression was observed in 40% (4/10) of methylated non‐neoplastic tissues and 87.5% (35/40) of unmethylated non‐tumours (p = 0.001). The demethylation caused by 5‐Aza‐CdR increased the p300 mRNA expression levels in oesophageal cancer cell lines. Conclusions p300 transcription silenced by promoter hypermethylation could play a role in the pathogenesis of oesophageal squamous cell carcinoma. PMID:17965222

  20. Both volumetry and functional connectivity of Heschl's gyrus are associated with auditory P300 in first episode schizophrenia.

    Science.gov (United States)

    Guo, Qian; Tang, Yingying; Li, Hui; Zhang, Tianhong; Li, Jianqi; Sheng, Jianhua; Liu, Dengtang; Li, Chunbo; Wang, Jijun

    2014-12-01

    Reduced gray matter volume in left superior temporal gyrus (STG) is considered to be associated with auditory P300 amplitude in schizophrenia. Little is known about possible pathological circuits regarding sub-regions of STG that contribute to auditory P300 abnormality in schizophrenia. The current study investigated gray matter volume in STG and functional connectivity of Heschl's gyrus in first-episode schizophrenia (FESZ), as well as their correlations with P300 amplitude. Nineteen FESZ patients and 19 healthy controls contributed MRI scans. Eighteen patients and 17 controls underwent auditory P300 test within 1 week after MRI scanning. STG structural abnormalities were analyzed using voxel-based morphometry (VBM) analysis. Bilateral Heschl's gyri (HG) were selected as seeds for FC analysis in resting MRI data. Correlations of P300 amplitude with gray matter alterations in STG and HG-based FC were analyzed using Pearson correlation analysis within each group. Compared to healthy controls, FESZ patients showed reduced gray matter in left STG and P300 amplitude. Gray matter volume of left Heschl's gyrus was positively correlated with P300 amplitude in FESZ patients. HG-based FC of resting fMRI was decreased in the inferior frontal gyrus (IFG), medial frontal gyrus (MFG), anterior cingulate cortex (ACC), and left temporal pole, whereas the same metric was increased in the lingual gyrus, precuneus and cerebellar tonsil among FESZ patients. FC between bilateral HG and precuneus was inversely correlated with P300 amplitude among healthy controls, and was absent among FES patients. The findings point towards both decreased volume of Heschl's gyrus and its altered functional pathways may contribute to auditory P300 abnormality in schizophrenia. Copyright © 2014 Elsevier B.V. All rights reserved.

  1. Valproic acid exposure decreases Cbp/p300 protein expression and histone acetyltransferase activity in P19 cells

    Energy Technology Data Exchange (ETDEWEB)

    Lamparter, Christina L. [Department of Biomedical and Molecular Sciences, Graduate Program in Pharmacology and Toxicology, Queen' s University, Kingston, Ontario K7L 3N6 (Canada); Winn, Louise M., E-mail: winnl@queensu.ca [Department of Biomedical and Molecular Sciences, Graduate Program in Pharmacology and Toxicology, Queen' s University, Kingston, Ontario K7L 3N6 (Canada); School of Environmental Studies, Queen' s University, Kingston, Ontario K7L 3N6 (Canada)

    2016-09-01

    The teratogenicity of the antiepileptic drug valproic acid (VPA) is well established and its inhibition of histone deacetylases (HDAC) is proposed as an initiating factor. Recently, VPA-mediated HDAC inhibition was demonstrated to involve transcriptional downregulation of histone acetyltransferases (HATs), which was proposed to compensate for the increased acetylation resulting from HDAC inhibition. Cbp and p300 are HATs required for embryonic development and deficiencies in either are associated with congenital malformations and embryolethality. The objective of the present study was to characterize Cbp/p300 following VPA exposure in P19 cells. Consistent with previous studies, exposure to 5 mM VPA over 24 h induced a moderate decrease in Cbp/p300 mRNA, which preceded a strong decrease in total cellular protein mediated by ubiquitin-proteasome degradation. Nuclear Cbp/p300 protein was also decreased following VPA exposure, although to a lesser extent. Total cellular and nuclear p300 HAT activity was reduced proportionately to p300 protein levels, however while total cellular HAT activity also decreased, nuclear HAT activity was unaffected. Using the Cbp/p300 HAT inhibitor C646, we demonstrated that HAT inhibition similarly affected many of the same endpoints as VPA, including increased reactive oxygen species and caspase-3 cleavage, the latter of which could be attenuated by pre-treatment with the antioxidant catalase. C646 exposure also decreased NF-κB/p65 protein, which was not due to reduced mRNA and was not attenuated with catalase pre-treatment. This study provides support for an adaptive HAT response following VPA exposure and suggests that reduced Cbp/p300 HAT activity could contribute to VPA-mediated alterations. - Highlights: • VPA exposure in vitro downregulates Cbp/p300 mRNA and induces protein degradation. • Cbp/p300 histone acetyltransferase activity is similarly reduced with VPA exposure. • Inhibition of Cbp/p300 acetyltransferase activity

  2. NF-κB suppresses HIF-1α response by competing for P300 binding

    International Nuclear Information System (INIS)

    Mendonca, Daniela B.S.; Mendonca, Gustavo; Aragao, Francisco J.L.; Cooper, Lyndon F.

    2011-01-01

    Research highlights: → p65 completely blocked HIF-1α activity at the HRE on different cell lines. → p65 caused minor changes in HIF-1α and HIF-1α target genes mRNA expression. → p65 reduced transcription of VEGF promoter. → p65 competes with HIF-1α for p300. -- Abstract: Hypoxia has emerged as a key determinant of osteogenesis. HIF-1α is the transcription factor mediating hypoxia responses that include induction of VEGF and related bone induction. Inflammatory signals antagonize bone repair via the NF-κB pathway. The present investigation explored the functional relationship of hypoxia (HIF-1α function) and inflammatory signaling (NF-κB) in stem like and osteoprogenitor cell lines. The potential interaction between HIF-1α and NF-κB signaling was explored by co-transfection studies in hFOB with p65, HIF-1α and 9x-HRE-luc or HIF-1α target genes reporter plasmids. Nuclear cross-talk was directly tested using the mammalian Gal4/VP16 two-hybrid, and confirmed by co-immunoprecipitation/western blotting assays. The results show that inflammatory stimulation (TNF-α treatment) causes a marked inhibition of HIF-1α function at the HRE in all cell lines studied. Also, co-transfection with p65 expression vector leads to reduced hVEGFp transcription after DFO-induced hypoxia. However, TNF-α treatment had little effect on HIF-1α mRNA levels. The functional interaction of Gal4-HIF-1α and VP16-p300 fusion proteins is effectively blocked by expression of p65 in a dose dependent manner. It was concluded that NF-κB-mediated inflammatory signaling is able to block HIF-1α transactivation at HRE-encoding genes by direct competition for p300 binding at the promoter. Inflammation may influence the stem cell niche and tissue regeneration by influencing cellular responses to hypoxia.

  3. Autoregressive Integrated Adaptive Neural Networks Classifier for EEG-P300 Classification

    Directory of Open Access Journals (Sweden)

    Demi Soetraprawata

    2013-06-01

    Full Text Available Brain Computer Interface has a potency to be applied in mechatronics apparatus and vehicles in the future. Compared to the other techniques, EEG is the most preferred for BCI designs. In this paper, a new adaptive neural network classifier of different mental activities from EEG-based P300 signals is proposed. To overcome the over-training that is caused by noisy and non-stationary data, the EEG signals are filtered and extracted using autoregressive models before passed to the adaptive neural networks classifier. To test the improvement in the EEG classification performance with the proposed method, comparative experiments were conducted using Bayesian Linear Discriminant Analysis. The experiment results show that the all subjects achieve a classification accuracy of 100%.

  4. An improved P300 pattern in BCI to catch user’s attention

    Science.gov (United States)

    Jin, Jing; Zhang, Hanhan; Daly, Ian; Wang, Xingyu; Cichocki, Andrzej

    2017-06-01

    Objective. Brain-computer interfaces (BCIs) can help patients who have lost control over most muscles but are still conscious and able to communicate or interact with the environment. One of the most popular types of BCI is the P300-based BCI. With this BCI, users are asked to count the number of appearances of target stimuli in an experiment. To date, the majority of visual P300-based BCI systems developed have used the same character or picture as the target for every stimulus presentation, which can bore users. Consequently, users attention may decrease or be negatively affected by adjacent stimuli. Approach. In this study, a new stimulus is presented to increase user concentration. Honeycomb-shaped figures with 1-3 red dots were used as stimuli. The number and the positions of the red dots in the honeycomb-shaped figure were randomly changed during BCI control. The user was asked to count the number of the dots presented in each flash instead of the number of times they flashed. To assess the performance of this new stimulus, another honeycomb-shaped stimulus, without red dots, was used as a control condition. Main results. The results showed that the honeycomb-shaped stimuli with red dots obtained significantly higher classification accuracies and information transfer rates (p  <  0.05) compared to the honeycomb-shaped stimulus without red dots. Significance. The results indicate that this proposed method can be a promising approach to improve the performance of the BCI system and can be an efficient method in daily application.

  5. An Efficient Framework for EEG Analysis with Application to Hybrid Brain Computer Interfaces Based on Motor Imagery and P300

    Directory of Open Access Journals (Sweden)

    Jinyi Long

    2017-01-01

    Full Text Available The hybrid brain computer interface (BCI based on motor imagery (MI and P300 has been a preferred strategy aiming to improve the detection performance through combining the features of each. However, current methods used for combining these two modalities optimize them separately, which does not result in optimal performance. Here, we present an efficient framework to optimize them together by concatenating the features of MI and P300 in a block diagonal form. Then a linear classifier under a dual spectral norm regularizer is applied to the combined features. Under this framework, the hybrid features of MI and P300 can be learned, selected, and combined together directly. Experimental results on the data set of hybrid BCI based on MI and P300 are provided to illustrate competitive performance of the proposed method against other conventional methods. This provides an evidence that the method used here contributes to the discrimination performance of the brain state in hybrid BCI.

  6. Influence of P300 latency jitter on event related potential-based brain-computer interface performance

    Science.gov (United States)

    Aricò, P.; Aloise, F.; Schettini, F.; Salinari, S.; Mattia, D.; Cincotti, F.

    2014-06-01

    Objective. Several ERP-based brain-computer interfaces (BCIs) that can be controlled even without eye movements (covert attention) have been recently proposed. However, when compared to similar systems based on overt attention, they displayed significantly lower accuracy. In the current interpretation, this is ascribed to the absence of the contribution of short-latency visual evoked potentials (VEPs) in the tasks performed in the covert attention modality. This study aims to investigate if this decrement (i) is fully explained by the lack of VEP contribution to the classification accuracy; (ii) correlates with lower temporal stability of the single-trial P300 potentials elicited in the covert attention modality. Approach. We evaluated the latency jitter of P300 evoked potentials in three BCI interfaces exploiting either overt or covert attention modalities in 20 healthy subjects. The effect of attention modality on the P300 jitter, and the relative contribution of VEPs and P300 jitter to the classification accuracy have been analyzed. Main results. The P300 jitter is higher when the BCI is controlled in covert attention. Classification accuracy negatively correlates with jitter. Even disregarding short-latency VEPs, overt-attention BCI yields better accuracy than covert. When the latency jitter is compensated offline, the difference between accuracies is not significant. Significance. The lower temporal stability of the P300 evoked potential generated during the tasks performed in covert attention modality should be regarded as the main contributing explanation of lower accuracy of covert-attention ERP-based BCIs.

  7. The portable P300 dialing system based on tablet and Emotiv Epoc headset.

    Science.gov (United States)

    Tong Jijun; Zhang Peng; Xiao Ran; Ding Lei

    2015-08-01

    A Brain-computer interface (BCI) is a novel communication system that translates brain signals into a control signal. Now with the appearance of the commercial EEG headsets and mobile smart platforms (tablet, smartphone), it is possible to develop the mobile BCI system, which can greatly improve the life quality of patients suffering from motor disease, such as amyotrophic lateral scleroses (ALS), multiple sclerosis, cerebral palsy and head trauma. This study adopted a 14-channel Emotiv EPOC headset and Microsoft surface pro 3 to realize a dialing system, which was represented by 4×3 matrices of alphanumeric characters. The performance of the online portable dialing system based on P300 is satisfying. The average classification accuracy reaches 88.75±10.57% in lab and 73.75±16.94% in metro, while the information transfer rate (ITR) reaches 7.17±1.80 and 5.05±2.17 bits/min respectively. This means the commercial EEG headset and tablet has good prospect in developing real time BCI system in realistic environments.

  8. A Fuzzy Integral Ensemble Method in Visual P300 Brain-Computer Interface

    Directory of Open Access Journals (Sweden)

    Francesco Cavrini

    2016-01-01

    Full Text Available We evaluate the possibility of application of combination of classifiers using fuzzy measures and integrals to Brain-Computer Interface (BCI based on electroencephalography. In particular, we present an ensemble method that can be applied to a variety of systems and evaluate it in the context of a visual P300-based BCI. Offline analysis of data relative to 5 subjects lets us argue that the proposed classification strategy is suitable for BCI. Indeed, the achieved performance is significantly greater than the average of the base classifiers and, broadly speaking, similar to that of the best one. Thus the proposed methodology allows realizing systems that can be used by different subjects without the need for a preliminary configuration phase in which the best classifier for each user has to be identified. Moreover, the ensemble is often capable of detecting uncertain situations and turning them from misclassifications into abstentions, thereby improving the level of safety in BCI for environmental or device control.

  9. Recommendations for Integrating a P300-Based Brain Computer Interface in Virtual Reality Environments for Gaming

    Directory of Open Access Journals (Sweden)

    Grégoire Cattan

    2018-05-01

    Full Text Available The integration of a P300-based brain–computer interface (BCI into virtual reality (VR environments is promising for the video games industry. However, it faces several limitations, mainly due to hardware constraints and constraints engendered by the stimulation needed by the BCI. The main limitation is still the low transfer rate that can be achieved by current BCI technology. The goal of this paper is to review current limitations and to provide application creators with design recommendations in order to overcome them. We also overview current VR and BCI commercial products in relation to the design of video games. An essential recommendation is to use the BCI only for non-complex and non-critical tasks in the game. Also, the BCI should be used to control actions that are naturally integrated into the virtual world. Finally, adventure and simulation games, especially if cooperative (multi-user appear the best candidates for designing an effective VR game enriched by BCI technology.

  10. P300 event-related potential as an indicator of inattentional deafness?

    Directory of Open Access Journals (Sweden)

    Louise Giraudet

    Full Text Available An analysis of airplane accidents reveals that pilots sometimes purely fail to react to critical auditory alerts. This inability of an auditory stimulus to reach consciousness has been coined under the term of inattentional deafness. Recent data from literature tends to show that tasks involving high cognitive load consume most of the attentional capacities, leaving little or none remaining for processing any unexpected information. In addition, there is a growing body of evidence for a shared attentional capacity between vision and hearing. In this context, the abundant information in modern cockpits is likely to produce inattentional deafness. We investigated this hypothesis by combining electroencephalographic (EEG measurements with an ecological aviation task performed under contextual variation of the cognitive load (high or low, including an alarm detection task. Two different audio tones were played: standard tones and deviant tones. Participants were instructed to ignore standard tones and to report deviant tones using a response pad. More than 31% of the deviant tones were not detected in the high load condition. Analysis of the EEG measurements showed a drastic diminution of the auditory P300 amplitude concomitant with this behavioral effect, whereas the N100 component was not affected. We suggest that these behavioral and electrophysiological results provide new insights on explaining the trend of pilots' failure to react to critical auditory information. Relevant applications concern prevention of alarms omission, mental workload measurements and enhanced warning designs.

  11. Potencial del Agua del suelo

    Directory of Open Access Journals (Sweden)

    Bustamante Heliodoro

    1986-12-01

    Full Text Available La energía potencial del agua presenta diferencias de un punto del suelo a otro; esas diferencias son las que originan el movimiento del agua de acuerdo a la tendencia universal de la materia en el sentido de moverse de donde la energía potencial es mayor a donde dicha energía es menor. En el suelo el agua en consecuencia se mueve hacia donde su energía decrece hasta lograr su estado de equilibrio. Se desprende entonces que la cantidad de energía potencial absoluta contenida en el agua, no es importante por sí misma, sino por su relación con la energía en diferentes lugares dentro del suelo. El concepto Potencial de agua del suelo es un criterio para esta energía.

  12. Latência e amplitude do P300 auditivo na doença de Alzheimer: uma revisão sistemática P300 latency and amplitude in Alzheimer's disease: a systematic review

    Directory of Open Access Journals (Sweden)

    Renata Valle Pedroso

    2012-08-01

    Full Text Available O P300 desempenha um papel fundamental como método de avaliação e monitoramento das demências, entre elas a doença de Alzheimer. OBJETIVO: Realizar uma busca por artigos que analisaram os valores de latência e amplitude de P300 na doença de Alzheimer. MÉTODOS: Foi realizada uma busca nas seguintes bases de dados: Web of Science, PubMed/Medline, Psyc Info, Biological Abstracts e Scielo. Utilizaram-se as seguintes palavras-chave: speed of information processing, speed of processing, information processing, aged, older, elderly, older people, alzheimer dementia, alzheimer disease, Alzheimer, além de referências cruzadas dos artigos selecionados. RESULTADOS: Foram encontrados oito estudos que preencheram os critérios de inclusão adotados para o presente trabalho. Estes estudos mostraram que existe um consenso em relação ao aumento da latência de P300 de idosos com doença de Alzheimer quando comparados com idosos sem a doença. Porém, verifica-se que, com relação à amplitude de P300, ainda não há um consenso, mas, isso pode estar relacionado às diferentes variáveis metodológicas adotadas nos estudos revisados. CONCLUSÃO: Há necessidade de se padronizar as variáveis envolvidas no método de avaliação do P300 para idosos com doença de Alzheimer, para que seja possível comparar os valores de latência e amplitude de P300 dessa população.The P300 plays a key role as a method for monitoring and evaluating dementia, including Alzheimer's disease. OBJECTIVE: The goal of this study was to search for articles which analyzed P300 latency and amplitude values in Alzheimer's disease. METHODS: We searched in the following databases: Web of Science, Pub Med, Psyc Info, Medline, Biological Abstracts and Scielo using the following keywords: speed of information processing, processing speed, information processing, aged, older, elderly, older people, alzheimer dementia, alzheimer disease, Alzheimer and cross-references of selected

  13. Classification effects of real and imaginary movement selective attention tasks on a P300-based brain-computer interface

    Science.gov (United States)

    Salvaris, Mathew; Sepulveda, Francisco

    2010-10-01

    Brain-computer interfaces (BCIs) rely on various electroencephalography methodologies that allow the user to convey their desired control to the machine. Common approaches include the use of event-related potentials (ERPs) such as the P300 and modulation of the beta and mu rhythms. All of these methods have their benefits and drawbacks. In this paper, three different selective attention tasks were tested in conjunction with a P300-based protocol (i.e. the standard counting of target stimuli as well as the conduction of real and imaginary movements in sync with the target stimuli). The three tasks were performed by a total of 10 participants, with the majority (7 out of 10) of the participants having never before participated in imaginary movement BCI experiments. Channels and methods used were optimized for the P300 ERP and no sensory-motor rhythms were explicitly used. The classifier used was a simple Fisher's linear discriminant. Results were encouraging, showing that on average the imaginary movement achieved a P300 versus No-P300 classification accuracy of 84.53%. In comparison, mental counting, the standard selective attention task used in previous studies, achieved 78.9% and real movement 90.3%. Furthermore, multiple trial classification results were recorded and compared, with real movement reaching 99.5% accuracy after four trials (12.8 s), imaginary movement reaching 99.5% accuracy after five trials (16 s) and counting reaching 98.2% accuracy after ten trials (32 s).

  14. A single high dose of escitalopram increases mismatch negativity without affecting processing negativity or P300 amplitude in healthy volunteers

    DEFF Research Database (Denmark)

    Wienberg, M; Glenthøj, Birte Yding; Jensen, K S

    2009-01-01

    processing. The present study was designed to replicate and further extent the results of our initial study on the effects of a low dose of escitalopram (10 mg) on MMN, PN and P300 amplitude. In a randomised, double-blind, cross-over experiment, 20 healthy male volunteers received either a single, orally...... administered dose of 15 mg escitalopram (a highly selective serotonin reuptake inhibitor (SSRI)) or placebo, after which their PN, MMN and P300 amplitude were assessed. Similar to our initial study with 10 mg escitalopram, 15 mg escitalopram significantly increased MMN, while it did not affect P300 amplitude....... In contrast to our initial study, however, the currently higher dose of escitalopram did not increase PN. Results support the view that a broad range of increased serotonergic activity enhances MMN, while the relationship between serotonin and PN seems more complex. The current study does not support...

  15. Performance of the Emotiv Epoc headset for P300-based applications.

    Science.gov (United States)

    Duvinage, Matthieu; Castermans, Thierry; Petieau, Mathieu; Hoellinger, Thomas; Cheron, Guy; Dutoit, Thierry

    2013-06-25

    For two decades, EEG-based Brain-Computer Interface (BCI) systems have been widely studied in research labs. Now, researchers want to consider out-of-the-lab applications and make this technology available to everybody. However, medical-grade EEG recording devices are still much too expensive for end-users, especially disabled people. Therefore, several low-cost alternatives have appeared on the market. The Emotiv Epoc headset is one of them. Although some previous work showed this device could suit the customer's needs in terms of performance, no quantitative classification-based assessments compared to a medical system are available. This paper aims at statistically comparing a medical-grade system, the ANT device, and the Emotiv Epoc headset by determining their respective performances in a P300 BCI using the same electrodes. On top of that, a review of previous Emotiv studies and a discussion on practical considerations regarding both systems are proposed. Nine healthy subjects participated in this experiment during which the ANT and the Emotiv systems are used in two different conditions: sitting on a chair and walking on a treadmill at constant speed. The Emotiv headset performs significantly worse than the medical device; observed effect sizes vary from medium to large. The Emotiv headset has higher relative operational and maintenance costs than its medical-grade competitor. Although this low-cost headset is able to record EEG data in a satisfying manner, it should only be chosen for non critical applications such as games, communication systems, etc. For rehabilitation or prosthesis control, this lack of reliability may lead to serious consequences. For research purposes, the medical system should be chosen except if a lot of trials are available or when the Signal-to-Noise Ratio is high. This also suggests that the design of a specific low-cost EEG recording system for critical applications and research is still required.

  16. DRD2 A1 allele and P300 abnormalities in obesity

    Energy Technology Data Exchange (ETDEWEB)

    Blum, K. [Univ. of Texas Health Science Center, San Antonio, TX (United States)]|[PATH Foundation, Princeton, NJ (United States); Wood, R.; Sheridan, L.P.J. [Univ. of Texas Health Science Center, San Antonio, TX (United States)] [and others

    1994-09-01

    Obesity is a heterogeneous and prevalent disorder having both inheritable and environmental components. The role of the dopamine system in P300 has been implicated. We genotyped 193 neuropsychiatrically ill patients with and without comorbid drug and alcohol/abuse/dependence and obesity for the prevalence of the A1 allele of the DRD2 gene. We found a significant linear trend ({chi}{sup 2} = 40.4, df=1, p<0.00001) where the percent prevalence of the A1 increased with increasing polysubstance abuse. Where the A1 allele was found in 44% of 40 obese subjects, the A1 allele prevalence was found in as much as 91% of 11 obese subjects with comorbid polysubstance abuse. 53 obese subjects having a mean body weight (BMI) of 34.6{+-}8.2 were mapped for brain electrical activity and compared with 15 controls with a BMI of 22.3{+-}3.0 (P<.001). The P3 amplitude was significantly different (two tailed; t=3.24, df=16.2, P = 0.005), whereas P3 latency was not significant. Preliminarily, we found a significant decreased P3 amplitude correlated with parental polysubstance abuse (p=0.4) with prolongation of P3 latency correlated with the three risk factors of parental substance abuse, chemical dependency and carbohydrate bingeing (P<0.02). Finally, in a small sample, the A1 allele was present in 25% of probands having 0 risk compared to 66% in those obese subjects with any risk. This work represents the first electrophysiological data to implicate P3 abnormalities in a subset of obesity and further confirms an association of the DRD2 gene and a electrophysiological marker previously indicated to have predictive value in vulnerability to addictive behaviors.

  17. Effects of caffeine and maltodextrin mouth rinsing on P300, brain imaging, and cognitive performance.

    Science.gov (United States)

    De Pauw, K; Roelands, B; Knaepen, K; Polfliet, M; Stiens, J; Meeusen, R

    2015-03-15

    Caffeine (CAF) and maltodextrin (MALT) mouth rinses (MR) improve exercise performance. The current experiment aims to determine the effect of CAF and MALT MR on cognitive performance and brain activity. Ten healthy male subjects (age 27 ± 3 yr) completed three experimental trials. Each trial included four Stroop tasks: two familiarization tasks, and one task before and one task after an MR period. The reaction time (in milliseconds) and accuracy (percent) of simple, congruent, and incongruent stimuli were assessed. Electroencephalography was applied throughout the experiment to record brain activity. The amplitudes and latencies of the P300 were determined during the Stroop tasks before and after the MR period. Subjects received MR with CAF (0.3 g/25 ml), MALT (1.6 g/25 ml), or placebo (PLAC) in a randomized, double-blind, crossover design. During MR, the brain imaging technique standardized low-resolution brain electromagnetic tomography was applied. Magnitude-based inferences showed that CAF MR is likely trivial (63.5%) and likely beneficial (36.4%) compared with PLAC MR, and compared with MALT MR likely beneficial to reaction time on incongruent stimuli (61.6%). Additionally, both the orbitofrontal and dorsolateral prefrontal cortex were activated only during CAF MR, potentially explaining the likely beneficial effect on reaction times. MALT MR increased brain activity only within the orbitofrontal cortex. However, this brain activation did not alter the reaction time. Furthermore, no significant differences in the accuracy of stimuli responses were observed between conditions. In conclusion, only CAF MR exerted a likely beneficial effect on reaction time due to the subsequent activation of both the orbitofrontal and dorsolateral prefrontal cortexes. Copyright © 2015 the American Physiological Society.

  18. Therapeutic effect of Cryptotanshinone on experimental rheumatoid arthritis through downregulating p300 mediated-STAT3 acetylation.

    Science.gov (United States)

    Wang, Ying; Zhou, Chun; Gao, Hui; Li, Cuixian; Li, Dong; Liu, Peiqing; Huang, Min; Shen, Xiaoyan; Liu, Liang

    2017-08-15

    The balance between T helper 17 (Th17) cells and regulatory T (Treg) cells, plays a critical role in rheumatoid arthritis (RA). The differentiation of Th17 cells requires the activation of STAT3, which determines the balance of Th17/Treg. Here, we investigated the therapeutic effect of Cryptotanshinone (CTS) on collagen induced mouse arthritis and explored the underlying mechanisms. Arthritis was induced in DBA/1 mice with bovine collagen type II and complete Freund's adjuvant. CTS was given at 20mgkg -1 d -1 or 60mgkg -1 d -1 by gavage for 6weeks. The immuno-inflammation and joint destruction were evaluated and the balance of Th17/Treg was determined. STAT3 acetylation and phosphorylation were detected by western blotting, and the involvement of p300 was investigated by siRNA and plasmid overexpression. CTS at a dose of 60mgkg -1 d -1 ameliorated the inflammation and joint destruction in CIA mice. It improved Th17/Treg imbalance, and inhibited both acetylation and phosphorylation of STAT3. CTS reduced p300 expression and its binding to STAT3, but increased phosphorylated AMPK. Knockdown of p300 mimicked the inhibitory effect of CTS on STAT3 acetylation and phosphorylation, which could be partially rescued by overexpression of p300-WT, but not p300-dominant negative (DN) construct. Our study suggested that the anti-arthritis effects of CTS were attained through suppression of p300-mediated STAT3 acetylation. Our data suggest that CTS might be a potential immune modulator for RA treatment. Copyright © 2017 Elsevier Inc. All rights reserved.

  19. A change in the parameters of P300 evoked potentials in relation to the degree of exacerbation of pain syndrome

    Directory of Open Access Journals (Sweden)

    A P Rachin

    2012-01-01

    Full Text Available In chronic pain, the state of suprasegmental brain structures (the cortex, limbic system, truncodiencephalic structures, which form the motivational-affective and cognitive components of pain behavior, actively affects pain afferentation as well. The purpose of the study was to comparatively analyze the parameters and topographic distribution of P300 cognitive evoked potential in patients with lower back pain. Sixty patients aged 22 to 60 years were examined. The authors made their clinical and neurological examinations, collected medical history data, and assessed back pain intensity by a visual analog scale. The findings were compared with the parameters of cognitive evoked potentials (the separating of P300 to count; keystroke in the recognition of significant stimuli; elaboration of a verbal and nonverbal visual stimulation protocol, by using emotionally significant stimuli. The processes of recognition and differentiation, those of directed attention, and the rate of information processing slowed down in patients with different stages of pain syndrome. The P300 separating procedure using the emotionally significant stimuli allows one to assess the specific features of chronization of pain syndromes and the presence of pain memory in the central nervous system of such patients. The estimation of P300 parameters over time or during treatment are of particular value for the optimization and evaluation of its efficiency.

  20. Cortical inhibition effect in musicians and non-musicians using P300 with and without contralateral stimulation.

    Science.gov (United States)

    Rabelo, Camila Maia; Neves-Lobo, Ivone Ferreira; Rocha-Muniz, Caroline Nunes; Ubiali, Thalita; Schochat, Eliane

    2015-01-01

    Musicians have more robust and efficient neural responses in the cortical and sub-cortical regions, demonstrating that musical experience benefits the processing of both non-linguistic and linguistic stimuli. This study aimed to verify P300's latency and amplitude behavioral using contralateral stimulation in musicians and non-musicians. This was a case-control study. Subjects were divided in two groups: musicians, comprising 30 professional musicians, and non-musicians, comprising 25 subjects without musical experience. The present study showed that the musicians had lower latencies and higher amplitudes than the non-musicians in the P300 without contralateral noise. For the P300 amplitude values, the difference between groups persisted, and the musicians presented significantly higher amplitude values compared with the non-musicians; additionally, the analysis of the noise effect on the P300 response showed that the latency values were significantly increased in the musicians. The central auditory nervous system of musicians presents peculiar characteristics of electrophysiological responses probably due to the plasticity imposed by musical practice. Copyright © 2014 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.

  1. Cortical inhibition effect in musicians and non-musicians using P300 with and without contralateral stimulation

    Directory of Open Access Journals (Sweden)

    Camila Maia Rabelo

    2015-02-01

    Full Text Available Introduction: Musicians have more robust and efficient neural responses in the cortical and sub-cortical regions, demonstrating that musical experience benefits the processing of both non-linguistic and linguistic stimuli. Objective: This study aimed to verify P300's latency and amplitude behavioral using contralateral stimulation in musicians and non-musicians. Methods: This was a case-control study. Subjects were divided in two groups: musicians, comprising 30 professional musicians, and non-musicians, comprising 25 subjects without musical experience. Results: The present study showed that the musicians had lower latencies and higher amplitudes than the non-musicians in the P300 without contralateral noise. For the P300 amplitude values, the difference between groups persisted, and the musicians presented significantly higher amplitude values compared with the non-musicians; additionally, the analysis of the noise effect on the P300 response showed that the latency values were significantly increased in the musicians. Conclusion: The central auditory nervous system of musicians presents peculiar characteristics of electrophysiological responses probably due to the plasticity imposed by musical practice.

  2. p300-mediated acetylation of the Rothmund-Thomson-syndrome gene product RECQL4 regulates its subcellular localization

    Czech Academy of Sciences Publication Activity Database

    Dietschy, T.; Shevelev, Igor; Pena-Diaz, J.; Hühn, D.; Kuenzle, S.; Mak, R.; Miah, M.F.; Hess, D.; Fey, M.; Hottiger, M.O.; Janščák, Pavel; Stagljar, I.

    2009-01-01

    Roč. 122, Pt 8 (2009), s. 1258-1267 ISSN 0021-9533 Institutional research plan: CEZ:AV0Z50520514 Keywords : RECQL4 * RecQ helicases * Genome stability * p300 * Protein acetylation Subject RIV: EB - Genetic s ; Molecular Biology Impact factor: 6.144, year: 2009

  3. A combined brain-computer interface based on P300 potentials and motion-onset visual evoked potentials.

    Science.gov (United States)

    Jin, Jing; Allison, Brendan Z; Wang, Xingyu; Neuper, Christa

    2012-04-15

    Brain-computer interfaces (BCIs) allow users to communicate via brain activity alone. Many BCIs rely on the P300 and other event-related potentials (ERPs) that are elicited when target stimuli flash. Although there have been considerable research exploring ways to improve P300 BCIs, surprisingly little work has focused on new ways to change visual stimuli to elicit more recognizable ERPs. In this paper, we introduce a "combined" BCI based on P300 potentials and motion-onset visual evoked potentials (M-VEPs) and compare it with BCIs based on each simple approach (P300 and M-VEP). Offline data suggested that performance would be best in the combined paradigm. Online tests with adaptive BCIs confirmed that our combined approach is practical in an online BCI, and yielded better performance than the other two approaches (P<0.05) without annoying or overburdening the subject. The highest mean classification accuracy (96%) and practical bit rate (26.7bit/s) were obtained from the combined condition. Copyright © 2012 Elsevier B.V. All rights reserved.

  4. Use of the Stockwell Transform in the Detection of P300 Evoked Potentials with Low-Cost Brain Sensors

    Directory of Open Access Journals (Sweden)

    Alan F. Pérez-Vidal

    2018-05-01

    Full Text Available The evoked potential is a neuronal activity that originates when a stimulus is presented. To achieve its detection, various techniques of brain signal processing can be used. One of the most studied evoked potentials is the P300 brain wave, which usually appears between 300 and 500 ms after the stimulus. Currently, the detection of P300 evoked potentials is of great importance due to its unique properties that allow the development of applications such as spellers, lie detectors, and diagnosis of psychiatric disorders. The present study was developed to demonstrate the usefulness of the Stockwell transform in the process of identifying P300 evoked potentials using a low-cost electroencephalography (EEG device with only two brain sensors. The acquisition of signals was carried out using the Emotiv EPOC® device—a wireless EEG headset. In the feature extraction, the Stockwell transform was used to obtain time-frequency information. The algorithms of linear discriminant analysis and a support vector machine were used in the classification process. The experiments were carried out with 10 participants; men with an average age of 25.3 years in good health. In general, a good performance (75–92% was obtained in identifying P300 evoked potentials.

  5. Lower P300 amplitude in eight-year-old offspring of alcoholic fathers with a delinquent history.

    Science.gov (United States)

    Viana-Wackermann, Paula C; Furtado, Erikson F; Esser, Günter; Schmidt, Martin H; Laucht, Manfred

    2007-06-01

    The aim of the present study was to investigate the P300 amplitude as a possible vulnerability marker in children of alcoholic (COA) fathers with and without paternal delinquency. Event-related potentials (ERPs) of 122 children aged 8 years (63 boys, 59 girls) were compared depending on father's alcoholism subtype: 30 COAs without paternal delinquency, 10 COAs with paternal delinquency, and 82 children of non-alcoholic and non-delinquent fathers. ERPs were recorded from Fz, Cz, and Pz, using an auditory oddball paradigm. Sinus tones of 60 dB HL were presented binaurally at 1,000 Hz (standard stimulus) and 2,000 Hz (target stimulus), at a relative frequency ratio of 80:20. Two trial blocks of 250 stimuli each were collected. Results indicated that only COAs with paternal delinquency displayed significant differences from the control group, characterized by reduced P300 amplitude at frontal site and in the second trial block. Thus, the combination of fathers' alcoholism and delinquency was more likely to relate to attenuated P300 amplitude in the offspring than paternal alcoholism alone. Our results suggest that both alcoholic and delinquent family history appear to play a role in P300 amplitude reduction in the offspring.

  6. Interfaz cerebro computador basada en P300 para la comunicación alternativa: estudio de caso en dos adolescentes en situación de discapacidad motora

    Directory of Open Access Journals (Sweden)

    Eliana García Cossio

    2011-01-01

    Full Text Available Las interfaces cerebro computador son sistemas que a partir del uso de las señales cerebrales hacen posible, que personas en situación de discapacidad motora severa, puedan controlar dispositivos externos, como: comunicadores, sillas de ruedas, entre otros. En este estudio piloto se describe cómo dos jóvenes con discapacidad motora, fueron entrenados para aprender a usar una Interfaz cerebro-computador (ICC controlada por el potencial evocado P300 a partir de electoencefalografía (EEG, para la comunicación alternativa de modo verbal. Se hizo uso de una matriz de estimulación de 4x3 (filas - columnas que contenía imágenes de jugadores de fútbol actuales. En primer lugar se realizaron unas pruebas de preparación que permitieron a los usuarios conocer el funcionamiento del sistema ICC. Seguido a esto se llevaron a cabo las pruebas reales que estaban conformadas por dos secciones: la sección de entrenamiento y la sección de pruebas de libre deletreo, en donde la persona podía seleccionar los íconos que deseara de la matriz a partir de uso de sus ondas de EEG. Los niveles promedio de porcentaje de acierto para cada uno de los usuarios en la prueba de libre deletreo fueron de 95% y 85%, respectivamente. El promedio de tiempo de elección de cada ícono fue de 36 segundos (1,67 letras por minuto.

  7. Reconociendo el carácter multifacético de la educación: los determinantes de los logros cognitivos y no cognitivos en la escuela media argentina

    Directory of Open Access Journals (Sweden)

    María Marta Formichella

    2017-01-01

    Full Text Available Antecedentes: Para brindar herramientas que permitan a las personas desarrollar todo su potencial, la educación debería no sólo proveer conocimientos y apti- tudes, sino también contribuir a la formación de actitudes, valores y disposicio- nes positivas. Los sistemas educativos deberían ser evaluados en función de este carácter multifacético de la educación, y la información disponible indica que los países difieren en la medida en que sus estudiantes adquieren tanto compe- tencias cognitivas como no cognitivas. Interesa por ello comprender mejor el desarrollo de ambos tipos de logros, proceso complejo que depende de factores personales, familiares, escolares y contextuales. Mientras que la mayoría de las investigaciones empíricas orientadas a explicar la calidad educativa ha conside- rado únicamente los logros cognitivos, el presente trabajo pone el foco en los no cognitivos. Métodos: Se estima un modelo de regresión multinivel multivariado que analiza simultáneamente los determinantes de dos resultados alcanzados por los alum- nos argentinos participantes del Programa para la Evaluación Internacional de Alumnos ( PISA 2012: uno cognitivo —la nota obtenida en la prueba de mate- máticas— y uno no cognitivo —la apertura hacia la resolución de problemas—. Resultados: Se hallan diferencias en los factores explicativos entre los dos tipos de logros: los colegios parecen cumplir un papel más relevante en la determinación del desempeño escolar cognitivo que en la formación de resultados no cognitivos. No obstante, factores como el género o el nivel socioeconómico del hogar inciden significativamente en ambos casos. Asimismo, si bien los atributos es- colares resultan menos relevantes que los individuales en la explicación de los dos resultados, se aprecia un margen para mejorar su desarrollo desde la escuela. Conclusiones: La inexistencia de homogeneidad respecto a las variables que deter - minan las dos clases de

  8. Cortical activities of single-trial P300 amplitudes modulated by memory load using simultaneous EEG-fMRI

    Science.gov (United States)

    Zhang, Qiushi; Zhao, Xiaojie; Zhu, Chaozhe; Yang, Xueqian; Yao, Li

    2015-03-01

    The functional magnetic resonance imaging (fMRI) researches on working memory have found that activation of cortical areas appeared dependent on memory load, and event-related potentials (ERP) studies have demonstrated that amplitudes of P300 decreased significantly when working memory load increased. However, the cortical activities related with P300 amplitudes under different memory loads remains unclear. Joint fMRI and EEG analysis which fusions the time and spatial information in simultaneous EEG-fMRI recording can reveal the regional activation at each ERP time point. In this paper, we first used wavelet transform to obtain the single-trial amplitudes of P300 caused by a digital N-back task in the simultaneous EEG-fMRI recording as the ERP feature sequences. Then the feature sequences in 1-back condition and 3-back condition were introduced into general linear model (GLM) separately as parametric modulations to compare the cortical activation under different memory loads. The results showed that the average amplitudes of P300 in 3-back significantly decreased than that in 1-back, and the activities induced by ERP feature sequences in 3-back also significantly decreased than that in the 1-back, including the insular, anterior cingulate cortex, right inferior frontal gyrus, and medial frontal gyrus, which were relevant to the storage, monitoring, and manipulation of information in working memory task. Moreover, the difference in the activation caused by ERP feature showed a positive correlation with the difference in behavioral performance. These findings demonstrated the locations of P300 amplitudes differences modulated by the memory load and its relationship with the behavioral performance.

  9. Aplicación de nuevas tecnologías en personas mayores con trastorno cognitivo leve-moderado desde la Terapia Ocupacional

    Directory of Open Access Journals (Sweden)

    María del Carmen Rodríguez Martínez

    2017-05-01

    Full Text Available Esta revisión bibliográfica pretende ofrecer una visión de las posibilidades que ofrecen las nuevas tecnologías a personas mayores con deterioro cognitivo leve-moderado para retardar o frenar los síntomas de deterioro cognitivo. Actualmente, las nuevas tecnologías de la información y la comunicación tienen mucho protagonismo y se han convertido en una herramienta con mucho potencial para este tipo de personas. Para ello, se han  analizado una serie de estudios sobre el uso de las nuevas tecnologías en personas mayores con trastornos cognitivos con el fin de ofrecer una visión más clara sobre los datos obtenidos hasta el día de hoy respecto a este campo de investigación en Terapia Ocupacional. Se seleccionaron un total de 204 artículos, tras un proceso de duplicación y tras pasar diferentes herramientas de calidad, quedaron un total de 7 artículos. Los resultados encontrados indican que las nuevas tecnologías contribuyen a disminuir algunos síntomas asociados a la enfermedad, como la ansiedad y la depresión, mejorando además ciertas funciones cognitivas en personas que tienen un deterioro cognitivo leve-moderado, siendo importante combinarlas con las terapias tradicionales.

  10. Tratamiento cognitivo-conductual en la menopausia

    OpenAIRE

    Gutiérrez Gómez-Calcerrada, Sonia

    2012-01-01

    Dada la carencia de alternativas terapéuticas a la terapia hormonal sustitutiva que aborden la sintomatología menopáusica y los diferentes aspectos que influyen en esta etapa, y la incapacidad de los tratamientos hormonales para la remisión de la sintomatología psicológica en la etapa climatérica, se plantea como objetivo de la presente investigación: establecer un programa de intervención cognitivo-conductual eficaz para mujeres climatéricas con sintomatología menopáusica.

  11. Moderate financial incentive does not appear to influence the P300 Concealed Information Test (CIT) effect in the Complex Trial Protocol (CTP) version of the CIT in a forensic scenario, while affecting P300 peak latencies and behavior.

    Science.gov (United States)

    Rosenfeld, J Peter; Sitar, Evan; Wasserman, Joshua; Ward, Anne

    2018-03-01

    Previous research indicated that the skin conductance response (SCR) of the Autonomic Nervous System (ANS) in the Concealed Information Test (CIT) is typically increased in subjects who are financially and otherwise incentivized to defeat the CIT (the paradoxical "motivational impairment" effect). This is not the case for RT-based CITs, nor for P300 tests based on the 3-stimulus protocol or Complex Trial Protocol for detection of cognitive malingering (although these are not the same as forensic CITs). The present report extends earlier studies of malingerers by running five groups of subjects (15-16 per group yielding 78 total) in a mock crime (forensic) scenario: paid (to beat the test) and unpaid, instructed and uninstructed, and simply guilty. There was no evidence that the "CIT effect" (probe-minus-irrelevant P300 differences) differed among groups, although behavioral differences among groups were seen. Copyright © 2018 Elsevier B.V. All rights reserved.

  12. Relaciones entre asertividad y estilos cognitivos

    Directory of Open Access Journals (Sweden)

    Aníbal Meza Borja

    2013-09-01

    Full Text Available Universitarias de nivel socio-económico alto y bajo fueron comparadas en su asertividad (general, AG, defensiva, AD; y expansiva, AE y en su estilo cognitivo (dependencia-independencia de campo DC-IC. Las de nivel alto tuvieron mayor independencia de campo no difirieron de las de nivel bajo en AG aunque respondían diferencialmente a ciertos ítems. No difirieron en AE pero si en AD, siendo las de nivel alto más asertivas. Los estilos cognitivos y la AD correlacionaban, siendo más asertivas las mujeres con independencia de campo. Two female samples from high (HS and low (LS social-economic level were evaluated in Assertiveness (General GA, Defensive DA and Expansive EA and in Cognitive Styles (Field Depedence-Independence FD-FI. Both samples differed on cognitive styles, being HS more field independent; both samples did not differed cuantitatively on GA but it could be noted some difference in the kind of assertiveness items to which they responded diferently. No difference was observed on EA but significant differences were found on DA, being HS more assertive.

  13. P300 com estímulo verbal e não verbal em adultos normo-ouvintes

    OpenAIRE

    Massa,Camila Gonçalves Polo; Rabelo,Camila Maia; Matas,Carla Gentile; Schochat,Eliane; Samelli,Alessandra Giannella

    2011-01-01

    O P300 é resultado da focalização da atenção a estímulos raros, dentre outros estímulos frequentes, e investiga a atenção e a memória recente, ambos dependentes da discriminação entre os estímulos, quer sejam verbais ou não verbais. OBJETIVO: Comparar o P300 com estímulos verbais e não verbais em indivíduos adultos com audição normal. MATERIAL E MÉTODO: Estudo prospectivo, no qual foram avaliados 15 sujeitos, com idades entre 22 e 55 anos, do gênero masculino, sem queixas auditivas. Foram sub...

  14. An efficient word typing P300-BCI system using a modified T9 interface and random forest classifier.

    Science.gov (United States)

    Akram, Faraz; Han, Seung Moo; Kim, Tae-Seong

    2015-01-01

    A typical P300-based spelling brain computer interface (BCI) system types a single character with a character presentation paradigm and a P300 classification system. Lately, a few attempts have been made to type a whole word with the help of a smart dictionary that suggests some candidate words with the input of a few initial characters. In this paper, we propose a novel paradigm utilizing initial character typing with word suggestions and a novel P300 classifier to increase word typing speed and accuracy. The novel paradigm involves modifying the Text on 9 keys (T9) interface, which is similar to the keypad of a mobile phone used for text messaging. Users can type the initial characters using a 3×3 matrix interface and an integrated custom-built dictionary that suggests candidate words as the user types the initials. Then the user can select one of the given suggestions to complete word typing. We have adopted a random forest classifier, which significantly improves P300 classification accuracy by combining multiple decision trees. We conducted experiments with 10 subjects using the proposed BCI system. Our proposed paradigms significantly reduced word typing time and made word typing more convenient by outputting complete words with only a few initial character inputs. The conventional spelling system required an average time of 3.47 min per word while typing 10 random words, whereas our proposed system took an average time of 1.67 min per word, a 51.87% improvement, for the same words under the same conditions. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. p300-mediated acetylation of the Rothmund-Thomson-syndrome gene product RECQL4 regulates its subcellular localization

    DEFF Research Database (Denmark)

    Dietschy, Tobias; Shevelev, Igor; Pena Diaz, Javier

    2009-01-01

    RECQL4 belongs to the conserved RecQ family of DNA helicases, members of which play important roles in the maintenance of genome stability in all organisms that have been examined. Although genetic alterations in the RECQL4 gene are reported to be associated with three autosomal recessive disorde...... by p300 regulates the trafficking of RECQL4 between the nucleus and the cytoplasm....

  16. Regulation of Nur77 protein turnover through acetylation and deacetylation induced by p300 and HDAC1.

    Science.gov (United States)

    Kang, Shin-Ae; Na, Hyelin; Kang, Hyun-Jin; Kim, Sung-Hye; Lee, Min-Ho; Lee, Mi-Ock

    2010-09-15

    Although the roles of Nur77, an orphan member of the nuclear hormone receptor superfamily, in the control of cellular proliferation, apoptosis, inflammation, and glucose metabolism, are well recognized, the molecular mechanism regulating the activity and expression of Nur77 is not fully understood. Acetylation of transcription factors has emerged recently as a major post-translational modification that regulates protein stability and transcriptional activity. Here, we examined whether Nur77 is acetylated, and we characterized potential associated factors. First, Nur77 was found to be an acetylated protein when examined by immunoprecipitation and western blotting using acetyl protein-specific antibodies. Second, expression of p300, which possesses histone acetyltransferase activity, enhanced the acetylation and protein stability of Nur77. Treatment with a histone deacetylase (HDAC) inhibitor, trichostatin A, also increased Nur77 acetylation. Among the several types of HDACs, HDAC1 was found as the major enzyme affecting protein level of Nur77. HDAC1 decreased the acetylation level, protein level, and transcriptional activity of Nur77. Interestingly, overexpression of Nur77 induced expression of both p300 and HDAC1. Finally, the expression of Nur77 increased along with that of p300, but decreased with induction of HDAC1 after treatment with epithelial growth factor, nerve growth factor, or 6-mercaptopurine, suggesting that the self-control of the acetylation status contributes to the transient induction of Nur77 protein. Taken together, these results demonstrate that acetylation of Nur77 is modulated by p300 and HDAC1, and suggest that acetylation is an important post-translational modification for the rapid turnover of Nur77 protein. Copyright 2010 Elsevier Inc. All rights reserved.

  17. Operation of a P300-based brain-computer interface by individuals with cervical spinal cord injury.

    Science.gov (United States)

    Ikegami, Shiro; Takano, Kouji; Saeki, Naokatsu; Kansaku, Kenji

    2011-05-01

    This study evaluates the efficacy of a P300-based brain-computer interface (BCI) with green/blue flicker matrices for individuals with cervical spinal cord injury (SCI). Ten individuals with cervical SCI (age 26-53, all male) and 10 age- and sex-matched able-bodied controls (age 27-52, all male) with no prior BCI experience were asked to input hiragana (Japanese alphabet) characters using the P300 BCI with two distinct types of visual stimuli, white/gray and green/blue, in an 8×10 flicker matrix. Both online and offline performance were evaluated. The mean online accuracy of the SCI subjects was 88.0% for the white/gray and 90.7% for the green/blue flicker matrices. The accuracy of the control subjects was 77.3% and 86.0% for the white/gray and green/blue, respectively. There was a significant difference in online accuracy between the two types of flicker matrix. SCI subjects performed with greater accuracy than controls, but the main effect was not significant. Individuals with cervical SCI successfully controlled the P300 BCI, and the green/blue flicker matrices were associated with significantly higher accuracy than the white/gray matrices. The P300 BCI with the green/blue flicker matrices is effective for use not only in able-bodied subjects, but also in individuals with cervical SCI. Copyright © 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

  18. Instructions to suppress semantic memory enhances or has no effect on P300 in a concealed information test (CIT).

    Science.gov (United States)

    Rosenfeld, J Peter; Ward, Anne; Drapekin, Jesse; Labkovsky, Elena; Tullman, Samuel

    2017-03-01

    The present study investigated the extent to which people can suppress semantic memory as indexed with the P300 ERP and the autobiographical implicit association test (aIAT). In EXP 1, participants (22) were run in a counterbalanced repeated measures study in both simply knowledgeable (SK) and knowledgeable with suppression (SP) conditions. A P300-based, concealed information test ("Complex Trial Protocol"; CTP) with a 50/50 Target/Nontarget (T/NT) ratio was given both with and without instructions to suppress semantic memories. The results showed increased P300s to probe name stimuli, reduced (but still high positive) aIAT d-scores, and increased simple reaction times to all stimuli used in ERP tests in the SP condition. EXP 2 was similar, but with SP and SK in two separate groups, and a 20/80 T/NT ratio. Again, ERP and aIAT results failed to show a suppression effect for semantic memory. The behavioral data suggest some task demand effects under suppression instructions, and that EXP 1 was more demanding than EXP 2. Copyright © 2017 Elsevier B.V. All rights reserved.

  19. Simultaneous detection of P300 and steady-state visually evoked potentials for hybrid brain-computer interface.

    Science.gov (United States)

    Combaz, Adrien; Van Hulle, Marc M

    2015-01-01

    We study the feasibility of a hybrid Brain-Computer Interface (BCI) combining simultaneous visual oddball and Steady-State Visually Evoked Potential (SSVEP) paradigms, where both types of stimuli are superimposed on a computer screen. Potentially, such a combination could result in a system being able to operate faster than a purely P300-based BCI and encode more targets than a purely SSVEP-based BCI. We analyse the interactions between the brain responses of the two paradigms, and assess the possibility to detect simultaneously the brain activity evoked by both paradigms, in a series of 3 experiments where EEG data are analysed offline. Despite differences in the shape of the P300 response between pure oddball and hybrid condition, we observe that the classification accuracy of this P300 response is not affected by the SSVEP stimulation. We do not observe either any effect of the oddball stimulation on the power of the SSVEP response in the frequency of stimulation. Finally results from the last experiment show the possibility of detecting both types of brain responses simultaneously and suggest not only the feasibility of such hybrid BCI but also a gain over pure oddball- and pure SSVEP-based BCIs in terms of communication rate.

  20. Application of the P300 Event-Related Potential in the Diagnosis of Epilepsy Disorder: A Review

    Directory of Open Access Journals (Sweden)

    Kandhasamy Sowndhararajan

    2018-03-01

    Full Text Available Epilepsy is one of the most serious chronical neurological disorders, affecting more than 50 million people worldwide. It can be defined as a spectrum disorder, and patients with epilepsy possess abnormalities in cognitive functions. A number of factors can cause cognitive dysfunctions in epileptic syndromes, including etiology, the age of onset, type of seizure and severity, duration, and antiepileptic drugs. Event-related potentials (ERPs are very useful clinical and research instruments to evaluate cognitive function in patients with neuropsychiatry disorders. Event-related potentials directly reflect cortical neuronal activity and provide a particular level of temporal resolution. Among various ERP components, the P300 is the most important component for assessing cognitive processes such as attention, working memory, and concentration. Numerous studies have reported the abnormalities in amplitude or latency of P300 component of ERP in epileptic patients, and these abnormalities are indicative of cognitive dysfunction. Therefore, the purpose of this review is to consolidate the existing literature in connection with the use of P300 in epileptic patients.

  1. After-effects of human-computer interaction indicated by P300 of the event-related brain potential.

    Science.gov (United States)

    Trimmel, M; Huber, R

    1998-05-01

    After-effects of human-computer interaction (HCI) were investigated by using the P300 component of the event-related brain potential (ERP). Forty-nine subjects (naive non-users, beginners, experienced users, programmers) completed three paper/pencil tasks (text editing, solving intelligence test items, filling out a questionnaire on sensation seeking) and three HCI tasks (text editing, executing a tutor program or programming, playing Tetris). The sequence of 7-min tasks was randomized between subjects and balanced between groups. After each experimental condition ERPs were recorded during an acoustic discrimination task at F3, F4, Cz, P3 and P4. Data indicate that: (1) mental after-effects of HCI can be detected by P300 of the ERP; (2) HCI showed in general a reduced amplitude; (3) P300 amplitude varied also with type of task, mainly at F4 where it was smaller after cognitive tasks (intelligence test/programming) and larger after emotion-based tasks (sensation seeking/Tetris); (4) cognitive tasks showed shorter latencies; (5) latencies were widely location-independent (within the range of 356-358 ms at F3, F4, P3 and P4) after executing the tutor program or programming; and (6) all observed after-effects were independent of the user's experience in operating computers and may therefore reflect short-term after-effects only and no structural changes of information processing caused by HCI.

  2. Efeitos do treinamento auditivo em idosos com Comprometimento Cognitivo Leve

    OpenAIRE

    Renata Rezende de Almeida Ávila; Cristina Ferraz Borges Murphy; Eliane Schochat

    2014-01-01

    INTRODUÇÃO: Pesquisas demonstram a existência do Transtorno do Processamento Auditivo em indivíduos com Comprometimento Cognitivo Leve. OBJETIVO: Verificar os efeitos de um treinamento auditivo, em indivíduos com comprometimento cognitivo leve. MÉTODOS: Participaram 25 indivíduos, com idades entre 69 e 91 anos e diagnóstico de Comprometimento Cognitivo Leve, sendo que, 10 receberam treinamento auditivo (grupo estudo), 10 receberam treinamento visual (grupo alternativo) e cinco não re...

  3. Terapia cognitivo-conductual y psicosis

    Directory of Open Access Journals (Sweden)

    CARLOS CUEVAS-YUST

    2002-01-01

    Full Text Available En una patología, la psicosis, tradicionalmente reservada al tratamiento psiquiátrico, resulta especialmente interesante y prometedora la aparición de las intervenciones psicológicas. De hecho, la terapia cognitivo-conductual (TCC está mostrando ser una aproximación efectiva en el tratamiento de síntomas psicóticos positivos resistentes a la medicación neuroléptica, existiendo incluso alguna evidencia de que podría contribuir a la reducción de las recaídas. En el presente trabajo describimos las etapas de la TCC en la psicosis, así como su adaptación a esta patología.

  4. P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain.

    Science.gov (United States)

    Iioka, Takashi; Furukawa, Keizo; Yamaguchi, Akira; Shindo, Hiroyuki; Yamashita, Shunichi; Tsukazaki, Tomoo

    2003-08-01

    The paired-like homeoprotein, Cart1, is involved in skeletal development. We describe here that the general coactivator p300/CBP controls the transcription activity of Cart1 through acetylation of a lysine residue that is highly conserved in other homeoproteins. Acetylation of this residue increases the interaction between p300/CBP and Cart1 and enhances its transcriptional activation. Cart1 encodes a paired-like homeoprotein expressed selectively in chondrocyte lineage during embryonic development. Although its target gene remains unknown, gene disruption studies have revealed that Cart1 plays an important role for craniofacial bone formation as well as limb development by cooperating with another homeoprotein, Alx4. In this report, we study the functional involvement of p300/CBP, coactivators with intrinsic histone acetyltransferase (HAT) activity, in the transcriptional control of Cart1. To study the transcription activity of Cart1, a reporter construct containing a putative Cart1 binding site was transiently transfected with the expression vectors of each protein. The interaction between p300/CBP and Cart1 was investigated by glutathione S-transferase (GST) pull-down, yeast two-hybrid, and immunoprecipitation assays. In vitro acetylation assay was performed with the recombinant p300-HAT domain and Cart1 in the presence of acetyl-CoA. p300 and CBP stimulate Cart1-dependent transcription activity, and this transactivation is inhibited by E1A and Tax, oncoproteins that suppress the activity of p300/CBP. Cart1 binds to p300 in vivo and in vitro, and this requires the homeodomain of Cart 1 and N-terminal 139 amino acids of p300. Confocal microscopy analysis shows that Cart1 recruits overexpressed and endogenous p300 to a Cart1-specific subnuclear compartment. Cart1 is acetylated in vivo and sodium butyrate and trichostatin A, histone deacetylase inhibitors, markedly enhance the transcription activity of Cart1. Deletion and mutagenesis analysis identifies the 131st

  5. Convergence role of transcriptional coactivator p300 and apparent modification on HMCs metabolic memory induced by high glucose

    Directory of Open Access Journals (Sweden)

    Hong SU

    2013-03-01

    Full Text Available Objective  To investigate the protein expression of transcriptional coactivator p300, acetylated histone H3 (Ac-H3 and Ac-H4 in human renal mesangial cell (HMCs as imitative "metabolic memory" in vitro, and explore the potential role of convergence point of p300. Methods  The HMCs were divided into the following groups: ① High glucose metabolic memory model: normal glucose group (NG, 5.5mmol/L D-glucose×2d, high glucose group (HG, 25mmol/L D-glucose×2d, memory groups (M1, M2, M3, 25mmol/L D-glucose×2days + 5.5mmol/L D-glucose×3d, 6d or 9d, persisting normal glucose group (NG, 5.5mmol/L D-glucose×9d. ② Advanced glycation end products memory model: normal glucose group (NG, 5.5mmol/ L D-glucose×2d, NG+AGEs group (AGEs, 5.5mmol/L D-glucose+250µg/ml AGEs×2d; AGEs memory group (AGEs-M, 5.5mmol/L D-glucose + 250µg/ml AGEs×2d + 5.5mmol/L D-glucose×3d; BSA control group (NG+BSA, 5.5mmol/L D-glucose + 250µg/ml BSA×2d. ③ H2O2 was used to simulate oxidative stress memory model: normal glucose group (NG, 5.5mmol/L D-glucose×2d, NG+H2O2 group (H2O2, 5.5mmol/L D-glucose +100µmol/L H2O2×30min; H2O2 memory group [(5.5mmol/ L D-glucose + 100µmol/L H2O2×30min + 5.5mmol/L D-glucose×3d]; normal glucose control group (NG3, 5.5mmol/L D-glucose×3d. ④ Transfection with PKCβ2 memory model: normal glucose group (NG, 5.5mmol/L D-glucose×2d; high glucose group (HG, 25mmol/L D-glucose×2d; memory group (M, 25mmol/L D-glucose×2d + 5.5mmol/L D-glucose×3d; Ad5-null memory group (HN, 25mmol/L D-glucose + Ad5-null×2d + 5.5mmol/L D-glucose×3d; PKCβ2 memory group (PO, 25mmol/L D-glucose + Ad5-PKCβ2×2d + 5.5mmol/L D-glucose×3d; inhibitor of PKCβ2 memory group (PI, 25mmol/L D-glucose×2d + 10µmol/L CGP53353 + 5.5mmol/L D-glucose×3d. The expression of intracellular reactive oxygen species (ROS was detected by fluorescence microscope and fluorescence microplate reader. The expression levels of p300, Ac-H3, Ac-H4 and PKCβ2 proteins were

  6. Entrenamiento Cognitivo de las Funciones Ejecutivas en la Edad Escolar

    Directory of Open Access Journals (Sweden)

    María Luisa Betancur-Caro

    2016-02-01

    Full Text Available En este artículo nuestro objetivo es evaluar y analizar el Rendimiento Académico de un niño en edad escolar a partir de un programa de entrenamiento cognitivo de las Funciones Ejecutivas. Realizamos el estudio de caso en tres momentos: evaluación inicial pretest con subpruebas de la Banfe y la ENI; identificamos el estado de las funciones ejecutivas, el entrenamiento cognitivo del Control Inhibitorio, la Fluidez y la Planeación, y la evaluación final postest con el mismo repertorio de la evaluación inicial, a fin de identificar los logros del entrenamiento cognitivo sobre las funciones ejecutivas y el rendimiento académico. Resultados y conclusiones: El entrenamiento cognitivo favoreció las funciones ejecutivas estimuladas; sin embargo, no logramos demostrar una relación concluyente entre las funciones ejecutivas y el rendimiento académico.

  7. Entrenamiento Cognitivo de las Funciones Ejecutivas en la Edad Escolar

    Directory of Open Access Journals (Sweden)

    María Luisa Betancur-Caro

    2016-01-01

    Full Text Available En este artículo nuestro objetivo es evaluar y analizar el Rendimiento Académico de un niño en edad escolar a partir de un programa de entrenamiento cognitivo de las Funciones Ejecutivas. Realizamos el estudio de caso en tres momentos: evaluación inicial pretest con subpruebas de la Banfe y la ENI; identificamos el estado de las funciones ejecutivas, el entrenamiento cognitivo del Control Inhibitorio, la Fluidez y la Planeación, y la evaluación final postest con el mismo repertorio de la evaluación inicial, a fin de identificar los logros del entrenamiento cognitivo sobre las funciones ejecutivas y el rendimiento académico. Resultados y conclusiones: El entrenamiento cognitivo favoreció las funciones ejecutivas estimuladas; sin embargo, no logramos demostrar una relación concluyente entre las funciones ejecutivas y el rendimiento académico.

  8. Adenovirus small E1A employs the lysine acetylases p300/CBP and tumor suppressor Rb to repress select host genes and promote productive virus infection.

    Science.gov (United States)

    Ferrari, Roberto; Gou, Dawei; Jawdekar, Gauri; Johnson, Sarah A; Nava, Miguel; Su, Trent; Yousef, Ahmed F; Zemke, Nathan R; Pellegrini, Matteo; Kurdistani, Siavash K; Berk, Arnold J

    2014-11-12

    Oncogenic transformation by adenovirus small e1a depends on simultaneous interactions with the host lysine acetylases p300/CBP and the tumor suppressor RB. How these interactions influence cellular gene expression remains unclear. We find that e1a displaces RBs from E2F transcription factors and promotes p300 acetylation of RB1 K873/K874 to lock it into a repressing conformation that interacts with repressive chromatin-modifying enzymes. These repressing p300-e1a-RB1 complexes specifically interact with host genes that have unusually high p300 association within the gene body. The TGF-β, TNF-, and interleukin-signaling pathway components are enriched among such p300-targeted genes. The p300-e1a-RB1 complex condenses chromatin in a manner dependent on HDAC activity, p300 lysine acetylase activity, the p300 bromodomain, and RB K873/K874 and e1a K239 acetylation to repress host genes that would otherwise inhibit productive virus infection. Thus, adenovirus employs e1a to repress host genes that interfere with viral replication. Copyright © 2014 Elsevier Inc. All rights reserved.

  9. Terapias cognitivo-conductuales en la fobia social, en adultos

    OpenAIRE

    San Vicente Montalbán, Ainara

    2015-01-01

    La fobia social es una enfermedad psiquiátrica que causa costes socioeconómicos significativos y que presenta una alta comorbilidad. Las terapias cognitivo-conductuales (TCC) pueden ser una alternativa de tratamiento efectiva, ya que buscan el cambio de pensamientos y comportamientos adquiridos en una enfermedad con un alto componente de aprendizaje. Objetivo: Verificar la efectividad de las terapias cognitivo-conductuales (TCC) con respecto a otros tratamientos empleados en la fobia soci...

  10. Recording visual evoked potentials and auditory evoked P300 at 9.4T static magnetic field.

    Science.gov (United States)

    Arrubla, Jorge; Neuner, Irene; Hahn, David; Boers, Frank; Shah, N Jon

    2013-01-01

    Simultaneous recording of electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) has shown a number of advantages that make this multimodal technique superior to fMRI alone. The feasibility of recording EEG at ultra-high static magnetic field up to 9.4 T was recently demonstrated and promises to be implemented soon in fMRI studies at ultra high magnetic fields. Recording visual evoked potentials are expected to be amongst the most simple for simultaneous EEG/fMRI at ultra-high magnetic field due to the easy assessment of the visual cortex. Auditory evoked P300 measurements are of interest since it is believed that they represent the earliest stage of cognitive processing. In this study, we investigate the feasibility of recording visual evoked potentials and auditory evoked P300 in a 9.4 T static magnetic field. For this purpose, EEG data were recorded from 26 healthy volunteers inside a 9.4 T MR scanner using a 32-channel MR compatible EEG system. Visual stimulation and auditory oddball paradigm were presented in order to elicit evoked related potentials (ERP). Recordings made outside the scanner were performed using the same stimuli and EEG system for comparison purposes. We were able to retrieve visual P100 and auditory P300 evoked potentials at 9.4 T static magnetic field after correction of the ballistocardiogram artefact using independent component analysis. The latencies of the ERPs recorded at 9.4 T were not different from those recorded at 0 T. The amplitudes of ERPs were higher at 9.4 T when compared to recordings at 0 T. Nevertheless, it seems that the increased amplitudes of the ERPs are due to the effect of the ultra-high field on the EEG recording system rather than alteration in the intrinsic processes that generate the electrophysiological responses.

  11. A polymorphism in the microRNA-30e precursor associated with major depressive disorder risk and P300 waveform.

    Science.gov (United States)

    Xu, Yong; Liu, Haiying; Li, Fei; Sun, Ning; Ren, Yan; Liu, Zhifen; Cao, Xiaohua; Wang, Yanfang; Liu, Pozi; Zhang, Kerang

    2010-12-01

    Growing evidence shows that the etiological causes and pathological processes underlying major depressive disorder (MDD) and schizophrenia (SCZ) overlap. Our previous study revealed a strong association between the polymorphism ss178077483 in the miRNA-30e precursor (pre-miR-30e) and the risk of SCZ. We thus hypothesized that this SCZ risk allele at the pre-miR-30e gene also confers risk of MDD. To explore the relationship between miR-30e ss178077483 and MDD, we conducted an association analyses in 1088 MDD patients and 1102 control subjects from the Han Chinese population. We also determined the effects of miR-30e ss178077483 on the development of P300 event-related potential components induced by an auditory odd-ball task. We detected a statistically significant positive association between miR-30e ss178077483 and MDD (allelic P=0.0287; genotypic P=0.0275). Moreover, the P300 latency was associated with miR-30e ss178077483 genotypes and the individuals with the C/T genotype have a longer P300 latency than those carrying the C/C genotype (P=0.009). Larger numbers of subjects and different ethnic groups would confirm and strengthen these preliminary findings. To our knowledge, this is the first evidence to suggest that miRNA polymorphisms may play an important role in MDD susceptibility. These findings also imply that certain miRNAs may be involved in the etiology of MDD. Copyright © 2010 Elsevier B.V. All rights reserved.

  12. REHABILITATION OF PATIENTS WITH ENCEPHALOPATHY CAUSED BY ACUTE CHEMICAL AGENTS POISONING. P300 OF AUDITORY EVENT RELATED POTENTIALS AND ELECTROENCEPHALOGRAPHY

    Directory of Open Access Journals (Sweden)

    I. U. Berezina

    2014-01-01

    Full Text Available RELEVANCE. Patients with encephalopathy due to acute chemical agents poisoning have some brain functioning changes and a cognitive impairment during the rehabilitation program. These changes require correction of appropriate diagnostic protocol and treatment.AIM. The aim of this study was to estimate changes of electroencephalography (EEG and the P3 component of the event related potential (P300 ERP that are observed in patients with encephalopathy due to acute chemical agents poisoning during stage of rehabilitation.MATERIAL AND METHODS. The study was included 25 patients (age 37 (32; 51 poisoned different kind of neurotoxic substances (drugs, ethanol and complicated by toxic and hypoxic encephalopathy. They have got the treatment of encephalopathy by mexidol intravenously, mesodiencephalic modulation (MDM and hyperbaric oxygen therapy (HBOT. All patients were recoded EEG (electroencephalograph of “MBN” company, Russia and P300 ERP (“Neuron-Spectrum-5/EP” of “Neurosoft”, Russia according to the international recommendations of clinical neurophysiologists. Neuropsychological testing was used for the assessment of cognitive functions.RESULTS. There were some disturbances in primary electroencephalograms of all subjects. The follow-up EEG recording showed the main group of patients who had got the treatment (mexidol, MDM, HBOT had more often (11 patients the EEG improvements compared to the controls (1 patient. The main group had more rarely the EEG impairments compared to the control group. 6 patients of main group and 3 patients of controls did not have EEG changes during the follow-up EEG recordings. All controls and 17 patients of the main group patients had different cognitive disturbances. After the treatment 15 patients of the main group had improved on neuropsychological tests (MMSE, Munsterberg test, Schulte table, Number Connecting Test. They also had a decrease in the N200, P300 peak latency and an increase in the N200, P300

  13. Interactions of Histone Acetyltransferase p300 with the Nuclear Proteins Histone and HMGB1, As Revealed by Single Molecule Atomic Force Spectroscopy.

    Science.gov (United States)

    Banerjee, S; Rakshit, T; Sett, S; Mukhopadhyay, R

    2015-10-22

    One of the important properties of the transcriptional coactivator p300 is histone acetyltransferase (HAT) activity that enables p300 to influence chromatin action via histone modulation. p300 can exert its HAT action upon the other nuclear proteins too--one notable example being the transcription-factor-like protein HMGB1, which functions also as a cytokine, and whose accumulation in the cytoplasm, as a response to tissue damage, is triggered by its acetylation. Hitherto, no information on the structure and stability of the complexes between full-length p300 (p300FL) (300 kDa) and the histone/HMGB1 proteins are available, probably due to the presence of unstructured regions within p300FL that makes it difficult to be crystallized. Herein, we have adopted the high-resolution atomic force microscopy (AFM) approach, which allows molecularly resolved three-dimensional contour mapping of a protein molecule of any size and structure. From the off-rate and activation barrier values, obtained using single molecule dynamic force spectroscopy, the biochemical proposition of preferential binding of p300FL to histone H3, compared to the octameric histone, can be validated. Importantly, from the energy landscape of the dissociation events, a model for the p300-histone and the p300-HMGB1 dynamic complexes that HAT forms, can be proposed. The lower unbinding forces of the complexes observed in acetylating conditions, compared to those observed in non-acetylating conditions, indicate that upon acetylation, p300 tends to weakly associate, probably as an outcome of charge alterations on the histone/HMGB1 surface and/or acetylation-induced conformational changes. To our knowledge, for the first time, a single molecule level treatment of the interactions of HAT, where the full-length protein is considered, is being reported.

  14. Complex network inference from P300 signals: Decoding brain state under visual stimulus for able-bodied and disabled subjects

    Science.gov (United States)

    Gao, Zhong-Ke; Cai, Qing; Dong, Na; Zhang, Shan-Shan; Bo, Yun; Zhang, Jie

    2016-10-01

    Distinguishing brain cognitive behavior underlying disabled and able-bodied subjects constitutes a challenging problem of significant importance. Complex network has established itself as a powerful tool for exploring functional brain networks, which sheds light on the inner workings of the human brain. Most existing works in constructing brain network focus on phase-synchronization measures between regional neural activities. In contrast, we propose a novel approach for inferring functional networks from P300 event-related potentials by integrating time and frequency domain information extracted from each channel signal, which we show to be efficient in subsequent pattern recognition. In particular, we construct brain network by regarding each channel signal as a node and determining the edges in terms of correlation of the extracted feature vectors. A six-choice P300 paradigm with six different images is used in testing our new approach, involving one able-bodied subject and three disabled subjects suffering from multiple sclerosis, cerebral palsy, traumatic brain and spinal-cord injury, respectively. We then exploit global efficiency, local efficiency and small-world indices from the derived brain networks to assess the network topological structure associated with different target images. The findings suggest that our method allows identifying brain cognitive behaviors related to visual stimulus between able-bodied and disabled subjects.

  15. Memory timeline: Brain ERP C250 (not P300) is an early biomarker of short-term storage.

    Science.gov (United States)

    Chapman, Robert M; Gardner, Margaret N; Mapstone, Mark; Dupree, Haley M; Antonsdottir, Inga M

    2015-04-16

    Brain event-related potentials (ERPs) offer a quantitative link between neurophysiological activity and cognitive performance. ERPs were measured while young adults performed a task that required storing a relevant stimulus in short-term memory. Using principal components analysis, ERP component C250 (maximum at 250 ms post-stimulus) was extracted from a set of ERPs that were separately averaged for various task conditions, including stimulus relevancy and stimulus sequence within a trial. C250 was more positive in response to task-specific stimuli that were successfully stored in short-term memory. This relationship between C250 and short-term memory storage of a stimulus was confirmed by a memory probe recall test where the behavioral recall of a stimulus was highly correlated with its C250 amplitude. ERP component P300 (and its subcomponents of P3a and P3b, which are commonly thought to represent memory operations) did not show a pattern of activation reflective of storing task-relevant stimuli. C250 precedes the P300, indicating that initial short-term memory storage may occur earlier than previously believed. Additionally, because C250 is so strongly predictive of a stimulus being stored in short-term memory, C250 may provide a strong index of early memory operations. Copyright © 2015 Elsevier B.V. All rights reserved.

  16. Asynchronous P300-based brain-computer interface to control a virtual environment: initial tests on end users.

    Science.gov (United States)

    Aloise, Fabio; Schettini, Francesca; Aricò, Pietro; Salinari, Serenella; Guger, Christoph; Rinsma, Johanna; Aiello, Marco; Mattia, Donatella; Cincotti, Febo

    2011-10-01

    Motor disability and/or ageing can prevent individuals from fully enjoying home facilities, thus worsening their quality of life. Advances in the field of accessible user interfaces for domotic appliances can represent a valuable way to improve the independence of these persons. An asynchronous P300-based Brain-Computer Interface (BCI) system was recently validated with the participation of healthy young volunteers for environmental control. In this study, the asynchronous P300-based BCI for the interaction with a virtual home environment was tested with the participation of potential end-users (clients of a Frisian home care organization) with limited autonomy due to ageing and/or motor disabilities. System testing revealed that the minimum number of stimulation sequences needed to achieve correct classification had a higher intra-subject variability in potential end-users with respect to what was previously observed in young controls. Here we show that the asynchronous modality performed significantly better as compared to the synchronous mode in continuously adapting its speed to the users' state. Furthermore, the asynchronous system modality confirmed its reliability in avoiding misclassifications and false positives, as previously shown in young healthy subjects. The asynchronous modality may contribute to filling the usability gap between BCI systems and traditional input devices, representing an important step towards their use in the activities of daily living.

  17. The Tax oncogene enhances ELL incorporation into p300 and P-TEFb containing protein complexes to activate transcription.

    Science.gov (United States)

    Fufa, Temesgen D; Byun, Jung S; Wakano, Clay; Fernandez, Alfonso G; Pise-Masison, Cynthia A; Gardner, Kevin

    2015-09-11

    The eleven-nineteen lysine-rich leukemia protein (ELL) is a key regulator of RNA polymerase II mediated transcription. ELL facilitates RNA polymerase II transcription pause site entry and release by dynamically interacting with p300 and the positive transcription elongation factor b (P-TEFb). In this study, we investigated the role of ELL during the HTLV-1 Tax oncogene induced transactivation. We show that ectopic expression of Tax enhances ELL incorporation into p300 and P-TEFb containing transcriptional complexes and the subsequent recruitment of these complexes to target genes in vivo. Depletion of ELL abrogates Tax induced transactivation of the immediate early genes Fos, Egr2 and NF-kB, suggesting that ELL is an essential cellular cofactor of the Tax oncogene. Thus, our study identifies a novel mechanism of ELL-dependent transactivation of immediate early genes by Tax and provides the rational for further defining the genome-wide targets of Tax and ELL. Published by Elsevier Inc.

  18. Implementation of active electrodes on a brain-computer interface and its application as P300 speller

    International Nuclear Information System (INIS)

    Aguero Rojas, Eliecer

    2013-01-01

    A brain computer interface has implemented using open hardware called Modular EEG, created by The OpenEEG Project and distributed by the company Olimex Ltd. That hardware is modified to use active electrodes, instead of passive electrodes, for acquiring electroencephalographic signals. The application has been given to the interface has been a speller P300; for which has used the BC12000 open software that has the necessary configuration for the application. P300 speller has used a protocol in each session so that could be standardize the method to different users. Valuing the results with three neuropsychological tests, was within the objectives; however, has not been achieved by the limitation in time of project implementation. A brain computer interface has been used with passive electrodes; implemented in the same way that the BCI with active electrodes; and has worked better than the interface with active electrodes. One of the major advantages that has been observed of passive electrodes on the actives has been the size of the same, because the liabilities are smaller and therefore, easier to place preventing the hair of the user, which increases the noise in the signal. (author) [es

  19. Cyclophilin B is involved in p300-mediated degradation of CHOP in tumor cell adaptation to hypoxia.

    Science.gov (United States)

    Jeong, K; Kim, H; Kim, K; Kim, S-J; Hahn, B-S; Jahng, G-H; Yoon, K-S; Kim, S S; Ha, J; Kang, I; Choe, W

    2014-03-01

    The regulation of CCAAT/enhancer-binding protein-homologous protein (CHOP), an endoplasmic reticulum (ER) stress-response factor, is key to cellular survival. Hypoxia is a physiologically important stress that induces cell death in the context of the ER, especially in solid tumors. Although our previous studies have suggested that Cyclophilin B (CypB), a molecular chaperone, has a role in ER stress, currently, there is no direct information supporting its mechanism under hypoxia. Here, we demonstrate for the first time that CypB is associated with p300 E4 ligase, induces ubiquitination and regulates the proteasomal turnover of CHOP, one of the well-known pro-apoptotic molecules under hypoxia. Our findings show that CypB physically interacts with the N-terminal α-helix domain of CHOP under hypoxia and cooperates with p300 to modulate the ubiquitination of CHOP. We also show that CypB is transcriptionally induced through ATF6 under hypoxia. Collectively, these findings demonstrate that CypB prevents hypoxia-induced cell death through modulation of ubiquitin-mediated CHOP protein degradation, suggesting that CypB may have an important role in the tight regulation of CHOP under hypoxia.

  20. Control or non-control state: that is the question! An asynchronous visual P300-based BCI approach

    Science.gov (United States)

    Pinegger, Andreas; Faller, Josef; Halder, Sebastian; Wriessnegger, Selina C.; Müller-Putz, Gernot R.

    2015-02-01

    Objective. Brain-computer interfaces (BCI) based on event-related potentials (ERP) were proven to be a reliable synchronous communication method. For everyday life situations, however, this synchronous mode is impractical because the system will deliver a selection even if the user is not paying attention to the stimulation. So far, research into attention-aware visual ERP-BCIs (i.e., asynchronous ERP-BCIs) has led to variable success. In this study, we investigate new approaches for detection of user engagement. Approach. Classifier output and frequency-domain features of electroencephalogram signals as well as the hybridization of them were used to detect the user's state. We tested their capabilities for state detection in different control scenarios on offline data from 21 healthy volunteers. Main results. The hybridization of classifier output and frequency-domain features outperformed the results of the single methods, and allowed building an asynchronous P300-based BCI with an average correct state detection accuracy of more than 95%. Significance. Our results show that all introduced approaches for state detection in an asynchronous P300-based BCI can effectively avoid involuntary selections, and that the hybrid method is the most effective approach.

  1. An evaluation of training with an auditory P300 brain-computer interface for the Japanese Hiragana syllabary

    Directory of Open Access Journals (Sweden)

    Sebastian Halder

    2016-09-01

    Full Text Available Gaze-independent brain-computer interfaces (BCIs are a possible communication channel for persons with paralysis. We investigated if it is possible to use auditory stimuli to create a BCI for the Japanese Hiragana syllabary, which has 46 Hiragana characters. Additionally, we investigated if training has an effect on accuracy despite the high amount of different stimuli involved. Able-bodied participants (N=6 were asked to select 25 syllables (out of fifty possible choices using a two step procedure: first the consonant (ten choices and then the vowel (five choices. This was repeated on three separate days. Additionally, a person with spinal cord injury (SCI participated in the experiment. Four out of six healthy participants reached Hiragana syllable accuracies above 70% and the information transfer rate increased from 1.7 bits/min in the first session to 3.2 bits/min in the third session. The accuracy of the participant with SCI increased from 12% (0.2 bits/min to 56% (2 bits/min in session three. Reliable selections from a 10×5 matrix using auditory stimuli were possible and performance is increased by training. We were able to show that auditory P300 BCIs can be used for communication with up to fifty symbols. This enables the use of the technology of auditory P300 BCIs with a variety of applications.

  2. An Evaluation of Training with an Auditory P300 Brain-Computer Interface for the Japanese Hiragana Syllabary.

    Science.gov (United States)

    Halder, Sebastian; Takano, Kouji; Ora, Hiroki; Onishi, Akinari; Utsumi, Kota; Kansaku, Kenji

    2016-01-01

    Gaze-independent brain-computer interfaces (BCIs) are a possible communication channel for persons with paralysis. We investigated if it is possible to use auditory stimuli to create a BCI for the Japanese Hiragana syllabary, which has 46 Hiragana characters. Additionally, we investigated if training has an effect on accuracy despite the high amount of different stimuli involved. Able-bodied participants ( N = 6) were asked to select 25 syllables (out of fifty possible choices) using a two step procedure: First the consonant (ten choices) and then the vowel (five choices). This was repeated on 3 separate days. Additionally, a person with spinal cord injury (SCI) participated in the experiment. Four out of six healthy participants reached Hiragana syllable accuracies above 70% and the information transfer rate increased from 1.7 bits/min in the first session to 3.2 bits/min in the third session. The accuracy of the participant with SCI increased from 12% (0.2 bits/min) to 56% (2 bits/min) in session three. Reliable selections from a 10 × 5 matrix using auditory stimuli were possible and performance is increased by training. We were able to show that auditory P300 BCIs can be used for communication with up to fifty symbols. This enables the use of the technology of auditory P300 BCIs with a variety of applications.

  3. Roles of p300 and cyclic adenosine monophosphate response element binding protein in high glucose-induced hypoxia-inducible factor 1α inactivation under hypoxic conditions.

    Science.gov (United States)

    Ding, Lingtao; Yang, Minlie; Zhao, Tianlan; Lv, Guozhong

    2017-05-01

    Given the high prevalence of diabetes and burn injuries worldwide, it is essential to dissect the underlying mechanism of delayed burn wound healing in diabetes patients, especially the high glucose-induced hypoxia-inducible factor 1 (HIF-1)-mediated transcription defects. Human umbilical vein endothelial cells were cultured with low or high concentrations of glucose. HIF-1α-induced vascular endothelial growth factor (VEGF) transcription was measured by luciferase assay. Immunofluorescence staining was carried out to visualize cyclic adenosine monophosphate response element binding protein (CREB) localization. Immunoprecipitation was carried out to characterize the association between HIF-1α/p300/CREB. To test whether p300, CREB or p300+CREB co-overexpression was sufficient to rescue the HIF-1-mediated transcription defect after high glucose exposure, p300, CREB or p300+CREB co-overexpression were engineered, and VEGF expression was quantified. Finally, in vitro angiogenesis assay was carried out to test whether the high glucose-induced angiogenesis defect is rescuable by p300 and CREB co-overexpression. Chronic high glucose treatment resulted in impaired HIF-1-induced VEGF transcription and CREB exclusion from the nucleus. P300 or CREB overexpression alone cannot rescue high glucose-induced HIF-1α transcription defects. In contrast, co-overexpression of p300 and CREB dramatically ameliorated high glucose-induced impairment of HIF-1-mediated VEGF transcription, as well as in vitro angiogenesis. Finally, we showed that co-overexpression of p300 and CREB rectifies the dissociation of HIF-1α-p300-CREB protein complex in chronic high glucose-treated cells. Both p300 and CREB are required for the function integrity of HIF-1α transcription machinery and subsequent angiogenesis, suggesting future studies to improve burn wound healing might be directed to optimization of the interaction between p300, CREB and HIF-1α. © 2016 The Authors. Journal of Diabetes

  4. The p300 event-related potential technique for libido assessment in women with hypoactive sexual desire disorder.

    Science.gov (United States)

    Vardi, Yoram; Sprecher, Elliot; Gruenwald, Ilan; Yarnitsky, David; Gartman, Irena; Granovsky, Yelena

    2009-06-01

    There is a need for an objective technique to assess the degree of hypoactive sexual desire disorder (HSDD). Recently, we described such a methodology (event-related potential technique [ERP]) based on recording of p300 electroencephalography (EEG) waves elicited by auditory stimuli during synchronous exposure to erotic films. To compare sexual interest of sexually healthy women to females with sexual dysfunction (FSD) using ERP, and to explore whether FSD women with and without HSDD would respond differently to two different types of erotic stimuli-films containing (I) or not containing (NI) sexual intercourse scenes. Twenty-two women with FSD, of which nine had HSDD only, and 30 sexually healthy women were assessed by the Female Sexual Functioning Index. ERP methodology was performed applying erotic NI or I films. Significant differences in percent of auditory p300 amplitude reduction (PR) in response to erotic stimuli within and between all three groups for each film type. PRs to each film type were similar in sexually healthy women (60.6% +/- 40.3 (NI) and 51.7% +/- 32.3 [I]), while in women with FSD, reduction was greater when viewing the NI vs. I erotic films (71.4% +/- 41.0 vs. 37.7% +/- 45.7; P = 0.0099). This difference was mainly due to the greater PR of the subgroup with HSDD in response to NI vs. I films (77.7% +/- 46.7 vs. 17.0% +/- 50.3) than in the FSD women without HSDD group or the sexually healthy women (67.5% +/- 38.7 vs. 50.4% +/- 39.4 respectively), P = 0.0084. For comparisons, we used the mixed-model one-way analysis of variance. Differences in neurophysiological response patterns between sexually healthy vs. sexually dysfunctional females may point to a specific inverse discrimination ability for sexually relevant information in the subgroup of women with HSDD. These findings suggest that the p300 ERP technique could be used as an objective quantitative tool for libido assessment in sexually dysfunctional women.

  5. Improving the accessibility at home: implementation of a domotic application using a p300-based brain computer interface system

    Directory of Open Access Journals (Sweden)

    Rebeca Corralejo Palacios

    2012-05-01

    Full Text Available The aim of this study was to develop a Brain Computer Interface (BCI application to control domotic devices usually present at home. Previous studies have shown that people with severe disabilities, both physical and cognitive ones, do not achieve high accuracy results using motor imagery-based BCIs. To overcome this limitation, we propose the implementation of a BCI application using P300 evoked potentials, because neither extensive training nor extremely high concentration level are required for this kind of BCIs. The implemented BCI application allows to control several devices as TV, DVD player, mini Hi-Fi system, multimedia hard drive, telephone, heater, fan and lights. Our aim is that potential users, i.e. people with severe disabilities, are able to achieve high accuracy. Therefore, this domotic BCI application is useful to increase

  6. AGO2 Negatively Regulates Type I Interferon Signaling Pathway by Competition Binding IRF3 with CBP/p300

    Directory of Open Access Journals (Sweden)

    Shengyu Wang

    2017-05-01

    Full Text Available Viral infection triggers a series of signaling cascades and host innate immune responses, including interferon (IFN production, which depends on coordinated activity of multiple transcription factors. IFN regulatory factor 3 (IRF3 and transcriptional coactivator CREB binding protein (CBP and/or p300 are core factors that participate in transcriptional complex formation in the nucleus. In general, cells balance the production of IFNs through suppressive and stimulative mechanisms, but viral infections can disrupt such equilibrium. This study determined that H5N1 viral infection reduced the distribution of human argonaute 2 (AGO2 in A549 cell nucleus. AGO2 did not block phosphorylation, nuclear translocation, and DNA binding ability of IRF3 but inhibited its association with CBP. Therefore, this newly revealed mechanism shows that cellular response leads to transfer of AGO2 from cell nucleus and promotes IFN-β expression to increase host survival during viral infection.

  7. Selección de Canales en Sistemas BCI basados en Potenciales P300 mediante Inteligencia de Enjambre

    Directory of Open Access Journals (Sweden)

    V. Martínez-Cagigal

    2017-10-01

    Full Text Available Resumen: Los sistemas Brain-Computer Interface (BCI se definen como sistemas de comunicación que monitorizan la actividad cerebral y traducen determinadas características, correspondientes a las intenciones del usuario, en comandos de control de un dispositivo. La selección de canales en los sistemas BCI es fundamental para evitar el sobre-entrenamiento del clasificador, reducir la carga computacional y aumentar la comodidad del usuario. A pesar de que se han desarrollado varios algoritmos con anterioridad para tal fin, las metaheurísticas basadas en inteligencia de enjambre aún no han sido suficientemente explotadas en los sistemas BCI basados en potenciales P300. En este estudio se muestra una comparativa entre cinco métodos de enjambre, basados en el comportamiento de sistemas biológicos, aplicados con el objetivo de optimizar la selección de canales en este tipo de sistemas. Los métodos se han evaluado sobre la base de datos de la “III BCI Competition 2005”, reportando precisiones similares o, en algunos casos, incluso más altas que las obtenidas sin realizar ningún tipo de selección. Dado que los cinco métodos se han demostrado capaces de disminuir drásticamente los 64 canales originales a menos de la mitad sin comprometer el rendimiento del sistema, así como de superar el conjunto típico de 8 canales y el método backward elimination, se concluye que todos ellos son adecuados para su aplicación en la selección de canales en sistemas P300-BCI. Abstract: Brain-Computer Interfaces (BCI are direct communication pathways between the brain and the environment that translate certain features, which correspond to users’ intentions, into device control commands. Channel selection in BCI systems is essential to avoid over-fitting, to reduce the computational cost and to increase the users’ comfort. Although several algorithms have previously developed for that purpose

  8. Optimizing the stimulus presentation paradigm design for the P300-based brain-computer interface using performance prediction

    Science.gov (United States)

    Mainsah, B. O.; Reeves, G.; Collins, L. M.; Throckmorton, C. S.

    2017-08-01

    Objective. The role of a brain-computer interface (BCI) is to discern a user’s intended message or action by extracting and decoding relevant information from brain signals. Stimulus-driven BCIs, such as the P300 speller, rely on detecting event-related potentials (ERPs) in response to a user attending to relevant or target stimulus events. However, this process is error-prone because the ERPs are embedded in noisy electroencephalography (EEG) data, representing a fundamental problem in communication of the uncertainty in the information that is received during noisy transmission. A BCI can be modeled as a noisy communication system and an information-theoretic approach can be exploited to design a stimulus presentation paradigm to maximize the information content that is presented to the user. However, previous methods that focused on designing error-correcting codes failed to provide significant performance improvements due to underestimating the effects of psycho-physiological factors on the P300 ERP elicitation process and a limited ability to predict online performance with their proposed methods. Maximizing the information rate favors the selection of stimulus presentation patterns with increased target presentation frequency, which exacerbates refractory effects and negatively impacts performance within the context of an oddball paradigm. An information-theoretic approach that seeks to understand the fundamental trade-off between information rate and reliability is desirable. Approach. We developed a performance-based paradigm (PBP) by tuning specific parameters of the stimulus presentation paradigm to maximize performance while minimizing refractory effects. We used a probabilistic-based performance prediction method as an evaluation criterion to select a final configuration of the PBP. Main results. With our PBP, we demonstrate statistically significant improvements in online performance, both in accuracy and spelling rate, compared to the conventional

  9. Optimizing the stimulus presentation paradigm design for the P300-based brain-computer interface using performance prediction.

    Science.gov (United States)

    Mainsah, B O; Reeves, G; Collins, L M; Throckmorton, C S

    2017-08-01

    The role of a brain-computer interface (BCI) is to discern a user's intended message or action by extracting and decoding relevant information from brain signals. Stimulus-driven BCIs, such as the P300 speller, rely on detecting event-related potentials (ERPs) in response to a user attending to relevant or target stimulus events. However, this process is error-prone because the ERPs are embedded in noisy electroencephalography (EEG) data, representing a fundamental problem in communication of the uncertainty in the information that is received during noisy transmission. A BCI can be modeled as a noisy communication system and an information-theoretic approach can be exploited to design a stimulus presentation paradigm to maximize the information content that is presented to the user. However, previous methods that focused on designing error-correcting codes failed to provide significant performance improvements due to underestimating the effects of psycho-physiological factors on the P300 ERP elicitation process and a limited ability to predict online performance with their proposed methods. Maximizing the information rate favors the selection of stimulus presentation patterns with increased target presentation frequency, which exacerbates refractory effects and negatively impacts performance within the context of an oddball paradigm. An information-theoretic approach that seeks to understand the fundamental trade-off between information rate and reliability is desirable. We developed a performance-based paradigm (PBP) by tuning specific parameters of the stimulus presentation paradigm to maximize performance while minimizing refractory effects. We used a probabilistic-based performance prediction method as an evaluation criterion to select a final configuration of the PBP. With our PBP, we demonstrate statistically significant improvements in online performance, both in accuracy and spelling rate, compared to the conventional row-column paradigm. By accounting for

  10. Abnormal frontoparietal synaptic gain mediating the P300 in patients with psychotic disorder and their unaffected relatives.

    Science.gov (United States)

    Díez, Álvaro; Ranlund, Siri; Pinotsis, Dimitris; Calafato, Stella; Shaikh, Madiha; Hall, Mei-Hua; Walshe, Muriel; Nevado, Ángel; Friston, Karl J; Adams, Rick A; Bramon, Elvira

    2017-06-01

    The "dysconnection hypothesis" of psychosis suggests that a disruption of functional integration underlies cognitive deficits and clinical symptoms. Impairments in the P300 potential are well documented in psychosis. Intrinsic (self-)connectivity in a frontoparietal cortical hierarchy during a P300 experiment was investigated. Dynamic Causal Modeling was used to estimate how evoked activity results from the dynamics of coupled neural populations and how neural coupling changes with the experimental factors. Twenty-four patients with psychotic disorder, twenty-four unaffected relatives, and twenty-five controls underwent EEG recordings during an auditory oddball paradigm. Sixteen frontoparietal network models (including primary auditory, superior parietal, and superior frontal sources) were analyzed and an optimal model of neural coupling, explaining diagnosis and genetic risk effects, as well as their interactions with task condition were identified. The winning model included changes in connectivity at all three hierarchical levels. Patients showed decreased self-inhibition-that is, increased cortical excitability-in left superior frontal gyrus across task conditions, compared with unaffected participants. Relatives had similar increases in excitability in left superior frontal and right superior parietal sources, and a reversal of the normal synaptic gain changes in response to targets relative to standard tones. It was confirmed that both subjects with psychotic disorder and their relatives show a context-independent loss of synaptic gain control at the highest hierarchy levels. The relatives also showed abnormal gain modulation responses to task-relevant stimuli. These may be caused by NMDA-receptor and/or GABAergic pathologies that change the excitability of superficial pyramidal cells and may be a potential biological marker for psychosis. Hum Brain Mapp 38:3262-3276, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  11. Evidence suggesting superiority of visual (verbal) vs. auditory test presentation modality in the P300-based, Complex Trial Protocol for concealed autobiographical memory detection.

    Science.gov (United States)

    Rosenfeld, J Peter; Ward, Anne; Frigo, Vincent; Drapekin, Jesse; Labkovsky, Elena

    2015-04-01

    One group of participants received a series of city name stimuli presented on trials of the Complex Trial Protocol (CTP) version of a P300-based, concealed information test (CIT). Stimuli were presented on alternating trials in either auditory or visual presentation modality. In 1/7 of the trials the participant's home town (probe) repeatedly appeared in a series of 6 other (irrelevant) repeated city names. In both modalities, probe stimuli produced larger P300s than irrelevant stimuli. Visual stimuli produced shorter behavioral reaction times and P300 latencies, as well as larger P300 probe amplitudes, probe-irrelevant amplitude differences, and individual diagnostic accuracies than the same stimuli presented in the auditory modality. Possible reasons for these effects are discussed, and subject to discussed limitations, the applied conclusion reached is that in all CITs, visual presentation of stimuli, if feasible, should be preferentially used. Copyright © 2015 Elsevier B.V. All rights reserved.

  12. Enteógenos e Inteligência Existencial: Plantas Mestres como Instrumentos Cognitivos

    Directory of Open Access Journals (Sweden)

    Kenneth Tupper

    2012-09-01

    Full Text Available DOI: 10.12957/periferia.2011.3946 A partir de recentes mudanças nas legislações em relação às drogasem diferentes países, investiguei o potencial dos enteógenos (i.e.,plantas psicoativas usadas como sacramentos espirituais comoinstrumentos para favorecer a inteligência existencial. PlantasMestres das Américas como a ayahuasca, os cogumelos depsilocibina, o peiote e o soma indo-ariano da Eurásia, são alguns dosexemplos de enteógenos que foram e continuam a ser utilizados, nopassado e no presente. Todas estas plantas foram reverenciadas porpessoas e culturas diferentes como instrumentos cognitivos quepromovem um mais rico entendimento cosmológico do mundo. Utilizoa teoria das múltiplas inteligências revisada por Gardner (1999 e suaformulação de uma inteligência “existencial” como uma lente teóricaatravés da qual se deve considerar as possibilidades cognitivas dosenteógenos e explorar potenciais caminhos na Educação.

  13. Entrenamiento Cognitivo de las Funciones Ejecutivas en la Edad Escolar

    OpenAIRE

    María Luisa Betancur-Caro; David A. Molina; Lilian Yohana Cañizales-Romaña

    2016-01-01

    En este artículo nuestro objetivo es evaluar y analizar el Rendimiento Académico de un niño en edad escolar a partir de un programa de entrenamiento cognitivo de las Funciones Ejecutivas. Realizamos el estudio de caso en tres momentos: evaluación inicial pretest con subpruebas de la Banfe y la ENI; identificamos el estado de las funciones ejecutivas, el entrenamiento cognitivo del Control Inhibitorio, la Fluidez y la Planeación, y la evaluación final postest con el mismo repertorio de la eval...

  14. Psilocybin disrupts sensory and higher order cognitive processing but not pre-attentive cognitive processing-study on P300 and mismatch negativity in healthy volunteers.

    Science.gov (United States)

    Bravermanová, Anna; Viktorinová, Michaela; Tylš, Filip; Novák, Tomáš; Androvičová, Renáta; Korčák, Jakub; Horáček, Jiří; Balíková, Marie; Griškova-Bulanova, Inga; Danielová, Dominika; Vlček, Přemysl; Mohr, Pavel; Brunovský, Martin; Koudelka, Vlastimil; Páleníček, Tomáš

    2018-02-01

    Disruption of auditory event-related evoked potentials (ERPs) P300 and mismatch negativity (MMN), electrophysiological markers of attentive and pre-attentive cognitive processing, is repeatedly described in psychosis and schizophrenia. Similar findings were observed in a glutamatergic model of psychosis, but the role of serotonergic 5-HT 2A receptors in information processing is less clear. We studied ERPs in a serotonergic model of psychosis, induced by psilocybin, a psychedelic with 5-HT 2A/C agonistic properties, in healthy volunteers. Twenty subjects (10M/10F) were given 0.26 mg/kg of psilocybin orally in a placebo-controlled, double-blind, cross-over design. ERPs (P300, MMN) were registered during the peak of intoxication. Correlations between measured electrophysiological variables and psilocin serum levels and neuropsychological effects were also analyzed. Psilocybin induced robust psychedelic effects and psychotic-like symptoms, decreased P300 amplitude (p = 0.009) but did not affect the MMN. Psilocybin's disruptive effect on P300 correlated with the intensity of the psychedelic state, which was dependent on the psilocin serum levels. We also observed a decrease in N100 amplitude (p = 0.039) in the P300 paradigm and a negative correlation between P300 and MMN amplitude (p = 0.014). Even though pre-attentive cognition (MMN) was not affected, processing at the early perceptual level (N100) and in higher-order cognition (P300) was significantly disrupted by psilocybin. Our results have implications for the role of 5-HT 2A receptors in altered information processing in psychosis and schizophrenia.

  15. [Evoked potentials N200/P300 disorders and clinical phenotype in Cuban families with paranoid schizophrenia: a family-based association study].

    Science.gov (United States)

    Guerra López, Seidel; Martín Reyes, Migdyrai; Pedroso Rodríguez, María de Los Ángeles; Reyes Berazain, Adnelys; Mendoza Quiñones, Raúl; Bravo Collazo, Tania Martha; Días de Villarvilla, Thais; Machado Cano, María Julia; Bobés León, María Antonieta

    2015-04-01

    N200 and P300 event-related evoked potentials provide sensitive measurements of sensory and cognitive function and have been used to study information processing in patients with schizophrenia and their unaffected first-degree relatives. Reduced amplitude and increased latency of N200 and P300 potentials have been consistently reported in schizophrenia. Thus, event-related evoked potentials abnormalities are promising possible biological markers for genetic vulnerability to schizophrenia. To assess the association of changes in latency, amplitude and topographic distribution of potentials N200 and P300 of patients with paranoid schizophrenia and their healthy first-degree relatives, in families with schizophrenia multiplex. We measured latency and amplitude of the N200 and P300 component of evoked potentials using an auditory odd-ball paradigm in 25 schizophrenic patients (probands) from 60 families multiply affected with paranoid schizophrenia, 23 of their non-schizophrenic first-degree relatives and 25 unrelated healthy controls, through a study of family association. Schizophrenic patients and their relatives showed significant latency prolongation and amplitude reduction of the N200 and P300 waves compared to controls. Left-temporal as compared to right-temporal N200 and P300 were significantly smaller in schizophrenic patients and their non-schizophrenic first-degree relatives than in controls. Our results suggest that event-related evoked potentials abnormalities may serve as markers of genetic vulnerability in schizophrenia. Confirming results of other researchers, this present study suggests that latency prolongation and amplitude reduction of the N200 and P300 waves and an altered topography at temporal sites may be a trait “marker” of paranoid schizophrenia.

  16. Effect of the green/blue flicker matrix for P300-based brain–computer interface: an EEG–fMRI study.

    Directory of Open Access Journals (Sweden)

    Shiro eIkegami

    2012-07-01

    Full Text Available The visual P300 brain–computer interface (BCI, a popular system for EEG-based BCI, utilizes the P300 event-related potential to select an icon arranged in a flicker matrix. In the conventional P300 BCI speller paradigm, white/gray luminance intensification of each row/column in the matrix is used. In an earlier study, we applied green/blue luminance and chromatic change in the P300 BCI system and reported that this luminance and chromatic flicker matrix was associated with better performance and greater subject comfort compared with the conventional white/gray luminance flicker matrix. In this study, we used simultaneous EEG-fMRI recordings to identify brain areas that were more enhanced in the green/blue flicker matrix than in the white/gray flicker matrix, as these may highlight areas devoted to improved P300-BCI performance. The peak of the positive wave in the EEG data was detected under both conditions, and the peak amplitudes were larger at the parietal and occipital electrodes, particularly in the late components, under the green/blue condition than under the white/gray condition. fMRI data showed activation in the bilateral parietal and occipital cortices, and these areas, particularly those in the right hemisphere, were more activated under the green/blue condition than under the white/gray condition. The parietal and occipital regions more involved in the green/blue condition were part of the areas devoted to conventional P300s. These results suggest that the green/blue flicker matrix was useful for enhancing the so-called P300 responses.

  17. Preliminary investigation of plasma levels of sex hormones and human growth factor(s, and P300 latency as correlates to cognitive decline as a function of gender

    Directory of Open Access Journals (Sweden)

    Kerner Mallory M

    2009-07-01

    Full Text Available Abstract Background Aging is marked by declines in levels of many sex hormones and growth factors, as well as in cognitive function. The P300 event-related potential has been established as a predictor of cognitive decline. We decided to determine if this measure, as well as 2 standard tests of memory and attention, may be correlated with serum levels of sex hormones and growth factors, and if there are any generalizations that could be made based on these parameters and the aging process. Findings In this large clinically based preliminary study several sex-stratified associations between hormone levels and cognition were observed, including (1 for males aged 30 to 49, both IGF-1 and IGFBP-3 significantly associated negatively with prolonged P300 latency; (2 for males aged 30 to 49, the spearman correlation between prolonged P300 latency and low free testosterone was significant; (3 for males aged 60 to 69, there was a significant negative correlation between P300 latency and DHEA levels; (4 for females aged 50 to 59 IGFBP-3 significantly associated negatively with prolonged P300 latency; (5 for females at all age periods, estrogen and progesterone were uncorrelated with P300 latency; and (6 for females aged 40 to 69, there was significant negative correlation between DHEA levels and P300 latency. Moreover there were no statistically significant correlations between any hormone and Wechsler Memory Scale-III (WMS-111. However, in females, there was a significant positive correlation between estrogen levels and the number of Attention Deficit Disorder (ADD complaints. Conclusion Given certain caveats including confounding factors involving psychiatric and other chronic diseases as well as medications, the results may still have important value. If these results could be confirmed in a more rigorously controlled investigation, it may have important value in the diagnosis, prevention and treatment of cognitive impairments and decline.

  18. Interaction of the transactivation domain of B-Myb with the TAZ2 domain of the coactivator p300: molecular features and properties of the complex.

    Directory of Open Access Journals (Sweden)

    Ojore Oka

    Full Text Available The transcription factor B-Myb is a key regulator of the cell cycle in vertebrates, with activation of transcription involving the recognition of specific DNA target sites and the recruitment of functional partner proteins, including the coactivators p300 and CBP. Here we report the results of detailed studies of the interaction between the transactivation domain of B-Myb (B-Myb TAD and the TAZ2 domain of p300. The B-Myb TAD was characterized using circular dichroism, fluorescence and NMR spectroscopy, which revealed that the isolated domain exists as a random coil polypeptide. Pull-down and spectroscopic experiments clearly showed that the B-Myb TAD binds to p300 TAZ2 to form a moderately tight (K(d ~1.0-10 µM complex, which results in at least partial folding of the B-Myb TAD. Significant changes in NMR spectra of p300 TAZ2 suggest that the B-Myb TAD binds to a relatively large patch on the surface of the domain (~1200 Å(2. The apparent B-Myb TAD binding site on p300 TAZ2 shows striking similarity to the surface of CBP TAZ2 involved in binding to the transactivation domain of the transcription factor signal transducer and activator of transcription 1 (STAT1, which suggests that the structure of the B-Myb TAD-p300 TAZ2 complex may share many features with that reported for STAT1 TAD-p300 TAZ2.

  19. Cognitive assessment in Amyotrophic Lateral Sclerosis by means of P300-Brain Computer Interface: a preliminary study.

    Science.gov (United States)

    Poletti, Barbara; Carelli, Laura; Solca, Federica; Lafronza, Annalisa; Pedroli, Elisa; Faini, Andrea; Zago, Stefano; Ticozzi, Nicola; Meriggi, Paolo; Cipresso, Pietro; Lulé, Dorothée; Ludolph, Albert C; Riva, Giuseppe; Silani, Vincenzo

    To investigate the use of P300-based Brain Computer Interface (BCI) technology for the administration of motor-verbal free cognitive tests in Amyotrophic Lateral Sclerosis (ALS). We recruited 15 ALS patients and 15 age- and education-matched healthy subjects. All participants underwent a BCI-based neuropsychological assessment, together with two standard cognitive screening tools (FAB, MoCA), two psychological questionnaires (BDI, STAI-Y) and a usability questionnaire. For patients, clinical and respiratory examinations were also performed, together with a behavioural assessment (FBI). Correlations were observed between standard cognitive and BCI-based neuropsychological assessment, mainly concerning execution times in the ALS group. Moreover, patients provided positive rates concerning the BCI perceived usability and subjective experience. Finally, execution times at the BCI-based neuropsychological assessment were useful to discriminate patients from controls, with patients achieving lower processing speed than controls regarding executive functions. The developed motor-verbal free neuropsychological battery represents an innovative approach, that could provide relevant information for clinical practice and ethical issues. Its use for cognitive evaluation throughout the course of ALS, currently not available by means of standard assessment, must be addressed in further longitudinal validation studies. Further work will be aimed at refining the developed system and enlarging the cognitive spectrum investigated.

  20. A novel P300-based brain-computer interface stimulus presentation paradigm: moving beyond rows and columns

    Science.gov (United States)

    Townsend, G.; LaPallo, B.K.; Boulay, C.B.; Krusienski, D.J.; Frye, G.E.; Hauser, C.K.; Schwartz, N.E.; Vaughan, T.M.; Wolpaw, J.R.; Sellers, E.W.

    2010-01-01

    Objective An electroencephalographic brain-computer interface (BCI) can provide a non-muscular means of communication for people with amyotrophic lateral sclerosis (ALS) or other neuromuscular disorders. We present a novel P300-based BCI stimulus presentation – the checkerboard paradigm (CBP). CBP performance is compared to that of the standard row/column paradigm (RCP) introduced by Farwell and Donchin (1988). Methods Using an 8×9 matrix of alphanumeric characters and keyboard commands, 18 participants used the CBP and RCP in counter-balanced fashion. With approximately 9 – 12 minutes of calibration data, we used a stepwise linear discriminant analysis for online classification of subsequent data. Results Mean online accuracy was significantly higher for the CBP, 92%, than for the RCP, 77%. Correcting for extra selections due to errors, mean bit rate was also significantly higher for the CBP, 23 bits/min, than for the RCP, 17 bits/min. Moreover, the two paradigms produced significantly different waveforms. Initial tests with three advanced ALS participants produced similar results. Furthermore, these individuals preferred the CBP to the RCP. Conclusions These results suggest that the CBP is markedly superior to the RCP in performance and user acceptability. Significance The CBP has the potential to provide a substantially more effective BCI than the RCP. This is especially important for people with severe neuromuscular disabilities. PMID:20347387

  1. Demencia tipo Alzheimer, deterioro cognitivo y toma de decisiones

    Directory of Open Access Journals (Sweden)

    Aurora Moreno

    2011-04-01

    Full Text Available El objetivo de este trabajo es el de conocer cómo es la toma de decisiones en la Demencia Tipo Alzheimer (DTA en situaciones de incertidumbre, si se manifiesta la tendencia al riesgo o no, y la relación que guarda la ejecución con el status cognitivo en cada una de las áreas evaluadas por los test de cribado del deterioro cognitivo propios de las demencias. Participaron 10 pacientes con DTA, y comparados con 10 sujetos controles. Se utilizó la Prueba Cartas (basada en la Iowa Gambling Task, donde los sujetos deben elegir entre varias opciones que entrañan más o menos riesgo, y una batería de cribado del deterioro cognitivo. Los resultados reflejaron que los sujetos con DTA en etapas iniciales presentan cierta tendencia al riesgo en las decisiones que toman y no desarrollan patrones estratégicos de elección. Parece que el deterioro cognitivo y el grado de afectación en las distintas áreas se relaciona con la forma en que toman decisiones.

  2. Efeitos do treinamento auditivo em idosos com Comprometimento Cognitivo Leve

    Directory of Open Access Journals (Sweden)

    Renata Rezende de Almeida Ávila

    2014-01-01

    Full Text Available INTRODUÇÃO: Pesquisas demonstram a existência do Transtorno do Processamento Auditivo em indivíduos com Comprometimento Cognitivo Leve. OBJETIVO: Verificar os efeitos de um treinamento auditivo, em indivíduos com comprometimento cognitivo leve. MÉTODOS: Participaram 25 indivíduos, com idades entre 69 e 91 anos e diagnóstico de Comprometimento Cognitivo Leve, sendo que, 10 receberam treinamento auditivo (grupo estudo, 10 receberam treinamento visual (grupo alternativo e cinco não receberam intervenção (grupo controle. Testes cognitivos e de processamento auditivo foram aplicados antes e após os treinamentos. RESULTADOS: Apenas o grupo estudo apresentou melhora significante para todas as habilidades auditivas testadas, mas com piora do desempenho para as habilidades cognitivas. CONCLUSÃO: O treinamento auditivo foi efetivo em relação às habilidades auditivas, mas não em relação às habilidades cognitivas.

  3. Creatividad, creencias paranormales y deterioro cognitivo en personas mayores

    Directory of Open Access Journals (Sweden)

    Inmaculada Méndez

    2015-08-01

    Full Text Available En el caso de las personas mayores, el pensamiento estético y la creatividad son formas de mantener activas la mente y la imaginación, contribuyendo a prevenir el deterioro cognitivo. Asimismo tener un sistema de creencias religiosas o incluso un sistema de creencias o experiencias paranormales ha demostrado ser beneficioso sobre la salud de los ancianos. El objetivo del estudio fue estudiar la relación entre la creatividad, el grado de deterioro cognitivo y las creencias paranormales. Se analizaron si existían diferencias atendiendo a características sociodemográficas. A un grupo de 36 personas mayores (16 varones con edades comprendidas entre los 66 y 95 años se le administró el Mini-Examen-Cognoscitivo (MEC, el Test CREA y la Escala Mejorada de Creencias Paranormales. Los resultados principales destacan que: los sujetos con mejor estado cognitivo son los más creativos; los menos creativos poseían más Creencias religiosas tradicionales e incluso mayor superstición; los ancianos con mejor estado cognitivo eran los menos supersticiosos. Es destacable que los varones eran más creativos, mientras que las mujeres destacaban en creencias religiosas tradicionales. El estudio permite reflexionar sobre la importancia de que los profesionales que trabajen con personas mayores lleven a cabo programas que favorezcan la creatividad e incluso recaben información sobre el sistema de creencias.

  4. Mejora de los procesos cognitivos y discapacidad intelectual

    OpenAIRE

    Grau Rubio, Claudia

    2006-01-01

    Se describen las principales dificultades en los procesos cognitivos básicos (percepción, atención, memoria, procesos ejecutivos) y las actividades y programas para mejorarlos. Asimismo, se describen las dificultades de algunos síndromes que cursan discapacidad intelectual.

  5. Hepatitis C virus core protein regulates p300/CBP co-activation function. Possible role in the regulation of NF-AT1 transcriptional activity

    International Nuclear Information System (INIS)

    Gomez-Gonzalo, Marta; Benedicto, Ignacio; Carretero, Marta; Lara-Pezzi, Enrique; Maldonado-Rodriguez, Alejandra; Moreno-Otero, Ricardo; Lai, Michael M.C.; Lopez-Cabrera, Manuel

    2004-01-01

    Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However, the mechanisms of core-mediated transcriptional regulation remain poorly understood. Oncogenic virus proteins often target p300/CBP, a known co-activator of a wide variety of transcription factors, to regulate the expression of cellular and viral genes. Here we demonstrate, for the first time, that HCV core protein interacts with p300/CBP and enhances both its acetyl-transferase and transcriptional activities. In addition, we demonstrate that nuclear core protein activates the NH 2 -terminal transcription activation domain (TAD) of NF-AT1 in a p300/CBP-dependent manner. We propose a model in which core protein regulates the co-activation function of p300/CBP and activates NF-AT1, and probably other p300/CBP-regulated transcription factors, by a novel mechanism involving the regulation of the acetylation state of histones and/or components of the transcriptional machinery

  6. A Basic Study on P300 Event-Related Potentials Evoked by Simultaneous Presentation of Visual and Auditory Stimuli for the Communication Interface

    Directory of Open Access Journals (Sweden)

    Masami Hashimoto

    2011-10-01

    Full Text Available We have been engaged in the development of a brain-computer interface (BCI based on the cognitive P300 event-related potentials (ERPs evoked by simultaneous presentation of visual and auditory stimuli in order to assist with the communication in severe physical limitation persons. The purpose of the simultaneous presentation of these stimuli is to give the user more choices as commands. First, we extracted P300 ERPs by either visual oddball paradigm or auditory oddball paradigm. Then amplitude and latency of the P300 ERPs were measured. Second, visual and auditory stimuli were presented simultaneously, we measured the P300 ERPs varying the condition of combinations of these stimuli. In this report, we used 3 colors as visual stimuli and 3 types of MIDI sounds as auditory stimuli. Two types of simultaneous presentations were examined. The one was conducted with random combination. The other was called group stimulation, combining one color, such as red, and one MIDI sound, such as piano, in order to make a group; three groups were made. Each group was presented to users randomly. We evaluated the possibility of BCI using these stimuli from the amplitudes and the latencies of P300 ERPs.

  7. Estilo cognitivo y logro académico Estilo cognitivo e rendimento escolar Cognitive Style and Academic Achievement

    Directory of Open Access Journals (Sweden)

    Omar López-Vargas

    2011-04-01

    Full Text Available El presente trabajo tiene como objetivo explorar las relaciones entre el estilo cognitivo, el aprendizaje autorregulado y el logro académico, en diferentes niveles del proceso de aprendizaje. La revisión de la literatura especializada indica que existe una estrecha relación entre el estilo cognitivo del estudiante y la capacidad de regulación de su aprendizaje con el desempeño académico en general.Este artigo explora as relações entre estilo cognitivo, aprendizagem auto-regulada e rendimento escolar com diferentes níveis de aprendizagem. A revisão da literatura mostra uma relação estreita entre o estilo cognitivo do aluno e a capacidade de regular a sua aprendizagem com o desempenho acadêmico.The aim of this article is to explore the relationships that exist between cognitive style, self-regulated learning and academic achievement at different levels in the learning process. The review of specialized literature suggests there is a close relationship between academic performance in general and a student's cognitive style and ability to regulate learning.

  8. A comparison of recording modalities of P300 event-related potentials (ERP) for brain-computer interface (BCI) paradigm.

    Science.gov (United States)

    Mayaud, L; Congedo, M; Van Laghenhove, A; Orlikowski, D; Figère, M; Azabou, E; Cheliout-Heraut, F

    2013-10-01

    A brain-computer interface aims at restoring communication and control in severely disabled people by identification and classification of EEG features such as event-related potentials (ERPs). The aim of this study is to compare different modalities of EEG recording for extraction of ERPs. The first comparison evaluates the performance of six disc electrodes with that of the EMOTIV headset, while the second evaluates three different electrode types (disc, needle, and large squared electrode). Ten healthy volunteers gave informed consent and were randomized to try the traditional EEG system (six disc electrodes with gel and skin preparation) or the EMOTIV Headset first. Together with the six disc electrodes, a needle and a square electrode of larger surface were simultaneously recording near lead Cz. Each modality was evaluated over three sessions of auditory P300 separated by one hour. No statically significant effect was found for the electrode type, nor was the interaction between electrode type and session number. There was no statistically significant difference of performance between the EMOTIV and the six traditional EEG disc electrodes, although there was a trend showing worse performance of the EMOTIV headset. However, the modality-session interaction was highly significant (P<0.001) showing that, while the performance of the six disc electrodes stay constant over sessions, the performance of the EMOTIV headset drops dramatically between 2 and 3h of use. Finally, the evaluation of comfort by participants revealed an increasing discomfort with the EMOTIV headset starting with the second hour of use. Our study does not recommend the use of one modality over another based on performance but suggests the choice should be made on more practical considerations such as the expected length of use, the availability of skilled labor for system setup and above all, the patient comfort. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  9. Applying dynamic data collection to improve dry electrode system performance for a P300-based brain-computer interface

    Science.gov (United States)

    Clements, J. M.; Sellers, E. W.; Ryan, D. B.; Caves, K.; Collins, L. M.; Throckmorton, C. S.

    2016-12-01

    Objective. Dry electrodes have an advantage over gel-based ‘wet’ electrodes by providing quicker set-up time for electroencephalography recording; however, the potentially poorer contact can result in noisier recordings. We examine the impact that this may have on brain-computer interface communication and potential approaches for mitigation. Approach. We present a performance comparison of wet and dry electrodes for use with the P300 speller system in both healthy participants and participants with communication disabilities (ALS and PLS), and investigate the potential for a data-driven dynamic data collection algorithm to compensate for the lower signal-to-noise ratio (SNR) in dry systems. Main results. Performance results from sixteen healthy participants obtained in the standard static data collection environment demonstrate a substantial loss in accuracy with the dry system. Using a dynamic stopping algorithm, performance may have been improved by collecting more data in the dry system for ten healthy participants and eight participants with communication disabilities; however, the algorithm did not fully compensate for the lower SNR of the dry system. An analysis of the wet and dry system recordings revealed that delta and theta frequency band power (0.1-4 Hz and 4-8 Hz, respectively) are consistently higher in dry system recordings across participants, indicating that transient and drift artifacts may be an issue for dry systems. Significance. Using dry electrodes is desirable for reduced set-up time; however, this study demonstrates that online performance is significantly poorer than for wet electrodes for users with and without disabilities. We test a new application of dynamic stopping algorithms to compensate for poorer SNR. Dynamic stopping improved dry system performance; however, further signal processing efforts are likely necessary for full mitigation.

  10. Histone acetyltransferase (HAT) activity of p300 modulates human T lymphotropic virus type 1 p30II-mediated repression of LTR transcriptional activity

    International Nuclear Information System (INIS)

    Michael, Bindhu; Nair, Amrithraj M.; Datta, Antara; Hiraragi, Hajime; Ratner, Lee; Lairmore, Michael D.

    2006-01-01

    Human T-lymphotropic virus type-1 (HTLV-1) is a deltaretrovirus that causes adult T cell leukemia/lymphoma, and is implicated in a variety of lymphocyte-mediated inflammatory disorders. HTLV-1 provirus has regulatory and accessory genes in four pX open reading frames. HTLV-1 pX ORF-II encodes two proteins, p13 II and p30 II , which are incompletely defined in virus replication or pathogenesis. We have demonstrated that pX ORF-II mutations block virus replication in vivo and that ORF-II encoded p30 II , a nuclear-localizing protein that binds with CREB-binding protein (CBP)/p300, represses CREB and Tax responsive element (TRE)-mediated transcription. Herein, we have identified p30 II motifs important for p300 binding and in regulating TRE-mediated transcription in the absence and presence of HTLV-1 provirus. Within amino acids 100-179 of p30 II , a region important for repression of LTR-mediated transcription, we identified a single lysine residue at amino acid 106 (K3) that significantly modulates the ability of p30 II to repress TRE-mediated transcription. Exogenous p300, in a dose-responsive manner, reverses p30 II -dependent repression of TRE-mediated transcription, in the absence or presence of the provirus, In contrast to wild type p300, p300 HAT mutants (defective in histone acetyltransferase activity) only partially rescued p30 II -mediated LTR repression. Deacetylation by histone deacetylase-1 (HDAC-1) enhanced p30 II -mediated LTR repression, while inhibition of deacetylation by trichostatin A decreases p30 II -mediated LTR repression. Collectively, our data indicate that HTLV-1 p30 II modulates viral gene expression in a cooperative manner with p300-mediated acetylation

  11. The utility of P300 as a schizophrenia endophenotype and predictive biomarker: clinical and socio-demographic modulators in COGS-2.

    Science.gov (United States)

    Turetsky, Bruce I; Dress, Erich M; Braff, David L; Calkins, Monica E; Green, Michael F; Greenwood, Tiffany A; Gur, Raquel E; Gur, Ruben C; Lazzeroni, Laura C; Nuechterlein, Keith H; Radant, Allen D; Seidman, Larry J; Siever, Larry J; Silverman, Jeremy M; Sprock, Joyce; Stone, William S; Sugar, Catherine A; Swerdlow, Neal R; Tsuang, Debby W; Tsuang, Ming T; Light, Gregory

    2015-04-01

    Reduced auditory P300 amplitude is a robust schizophrenia deficit exhibiting the qualities of a viable genetic endophenotype. These include heritability, test-retest reliability, and trait-like stability. Recent evidence suggests that P300 may also serve as a predictive biomarker for transition to psychosis during the schizophrenia prodrome. Historically, the utility of the P300 has been limited by its clinical nonspecificity, cross-site measurement variability, and required EEG expertise. The Consortium on the Genetics of Schizophrenia (COGS-2) study provided an opportunity to examine the consistency of the measure across multiple sites with varying degrees of EEG experience, and to identify important modulating factors that contribute to measurement variability. Auditory P300 was acquired from 649 controls and 587 patients at 5 sites. An overall patient deficit was observed with effect size 0.62. Each site independently observed a significant patient deficit, but site differences also existed. In patients, site differences reflected clinical differences in positive symptomatology and functional capacity. In controls, site differences reflected differences in racial stratification, smoking and substance use history. These factors differentially suppressed the P300 response, but only in control subjects. This led to an attenuated patient-control difference among smokers and among African Americans with history of substance use. These findings indicate that the P300 can be adequately assessed quantitatively, across sites, without substantial EEG expertise. Measurements are suitable for both genetic endophenotype analyses and studies of psychosis risk and conversion. However, careful attention must be given to selection of appropriate comparison samples to avoid misleading false negative results. Copyright © 2014 Elsevier B.V. All rights reserved.

  12. On the Relationship Between Attention Processing and P300-Based Brain Computer Interface Control in Amyotrophic Lateral Sclerosis

    Directory of Open Access Journals (Sweden)

    Angela Riccio

    2018-05-01

    Full Text Available Our objective was to investigate the capacity to control a P3-based brain-computer interface (BCI device for communication and its related (temporal attention processing in a sample of amyotrophic lateral sclerosis (ALS patients with respect to healthy subjects. The ultimate goal was to corroborate the role of cognitive mechanisms in event-related potential (ERP-based BCI control in ALS patients. Furthermore, the possible differences in such attentional mechanisms between the two groups were investigated in order to unveil possible alterations associated with the ALS condition. Thirteen ALS patients and 13 healthy volunteers matched for age and years of education underwent a P3-speller BCI task and a rapid serial visual presentation (RSVP task. The RSVP task was performed by participants in order to screen their temporal pattern of attentional resource allocation, namely: (i the temporal attentional filtering capacity (scored as T1%; and (ii the capability to adequately update the attentive filter in the temporal dynamics of the attentional selection (scored as T2%. For the P3-speller BCI task, the online accuracy and information transfer rate (ITR were obtained. Centroid Latency and Mean Amplitude of N200 and P300 were also obtained. No significant differences emerged between ALS patients and Controls with regards to online accuracy (p = 0.13. Differently, the performance in controlling the P3-speller expressed as ITR values (calculated offline were compromised in ALS patients (p < 0.05, with a delay in the latency of P3 when processing BCI stimuli as compared with Control group (p < 0.01. Furthermore, the temporal aspect of attentional filtering which was related to BCI control (r = 0.51; p < 0.05 and to the P3 wave amplitude (r = 0.63; p < 0.05 was also altered in ALS patients (p = 0.01. These findings ground the knowledge required to develop sensible classes of BCI specifically designed by taking into account the influence of the cognitive

  13. Resveratrol Promotes Nerve Regeneration via Activation of p300 Acetyltransferase-Mediated VEGF Signaling in a Rat Model of Sciatic Nerve Crush Injury.

    Science.gov (United States)

    Ding, Zhuofeng; Cao, Jiawei; Shen, Yu; Zou, Yu; Yang, Xin; Zhou, Wen; Guo, Qulian; Huang, Changsheng

    2018-01-01

    Peripheral nerve injuries are generally associated with incomplete restoration of motor function. The slow rate of nerve regeneration after injury may account for this. Although many benefits of resveratrol have been shown in the nervous system, it is not clear whether resveratrol could promote fast nerve regeneration and motor repair after peripheral nerve injury. This study showed that the motor deficits caused by sciatic nerve crush injury were alleviated by daily systematic resveratrol treatment within 10 days. Resveratrol increased the number of axons in the distal part of the injured nerve, indicating enhanced nerve regeneration. In the affected ventral spinal cord, resveratrol enhanced the expression of several vascular endothelial growth factor family proteins (VEGFs) and increased the phosphorylation of p300 through Akt signaling, indicating activation of p300 acetyltransferase. Inactivation of p300 acetyltransferase reversed the resveratrol-induced expression of VEGFs and motor repair in rats that had undergone sciatic nerve crush injury. The above results indicated that daily systematic resveratrol treatment promoted nerve regeneration and led to rapid motor repair. Resveratrol activated p300 acetyltransferase-mediated VEGF signaling in the affected ventral spinal cord, which may have thus contributed to the acceleration of nerve regeneration and motor repair.

  14. Conflict and inhibition differentially affect the N200/P300 complex in a combined go/nogo and stop-signal task.

    Science.gov (United States)

    Enriquez-Geppert, Stefanie; Konrad, Carsten; Pantev, Christo; Huster, René J

    2010-06-01

    Conflict and inhibition are considered to exert strong influences on the neurophysiological N200 and P300 brain responses as evoked in go/nogo and stop-signal tasks. In order to separate their underlying neural and functional mechanisms, the current experiment manipulated both conflict and inhibition. To do so, the go/nogo and stop-signal tasks were merged into one paradigm. Conflict was manipulated by varying go-trial frequencies across blocks (75% vs. 25%). Motor inhibition was manipulated by using go, nogo and stop trials each representing a different load of inhibition. Event-related potentials (ERPs) as well as current density reconstructions (CDRs) of fifteen healthy participants were analyzed. Overall, infrequent trials evoked significantly more pronounced N200s than frequent trials. The P300 predominantly revealed significant variations between trial types (go, nogo, stop). Estimated source activations of the MCC and the IFC supported the ERP results; N200-related effects were revealed in both regions, whereas the condition-specific variations of the P300 were only observed in the IFC. The results indicate that the N200 primarily reflects conflict-related effects whereas the P300 predominantly represents motor inhibition. Copyright 2010 Elsevier Inc. All rights reserved.

  15. 3D structure prediction of histone acetyltransferase (HAC proteins of the p300/CBP family and their interactome in Arabidopsis thaliana

    Directory of Open Access Journals (Sweden)

    Amar Cemanovic

    2014-09-01

    Full Text Available Histone acetylation is an important posttranslational modification correlated with gene activation. In Arabidopsis thaliana the histone acetyltransferase (HAC proteins of the CBP family are homologous to animal p300/CREB (cAMP-responsive element-binding proteins, which are important histone acetyltransferases participating in many physiological processes, including proliferation, differentiation, and apoptosis. In this study the 3-D structure of all HAC protein subunits in Arabidopsis thaliana: HAC1, HAC2, HAC4, HAC5 and HAC12 is predicted by homology modeling and confirmed by Ramachandran plot analysis. The amino acid sequences HAC family members are highly similar to the sequences of the homologous human p300/CREB protein. Conservation of p300/CBP domains among the HAC proteins was examined further by sequence alignment and pattern search. The domains of p300/CBP required for the HAC function, such as PHD, TAZ and ZZ domains, are conserved in all HAC proteins. Interactome analysis revealed that HAC1, HAC5 and HAC12 proteins interact with S-adenosylmethionine-dependent methyltransferase domaincontaining protein that shows methyltransferase activity, suggesting an additional function of the HAC proteins. Additionally, HAC5 has a strong interaction value for the putative c-myb-like transcription factor MYB3R-4, which suggests that it also may have a function in regulation of DNA replication.

  16. Menadione and ethacrynic acid inhibit the hypoxia-inducible factor (HIF) pathway by disrupting HIF-1α interaction with p300.

    Science.gov (United States)

    Na, Yu-Ran; Han, Ki-Cheol; Park, Hyunsung; Yang, Eun Gyeong

    2013-05-17

    Hypoxia is a general characteristic of most solid malignancies and intimately related to neoplastic diseases and cancer progression. Homeostatic response to hypoxia is primarily mediated by hypoxia inducible factor (HIF)-1α that elicits transcriptional activity through recruitment of the CREB binding protein (CBP)/p300 coactivator. Targeted blockade of HIF-1α binding to CBP/p300 would thus constitute a novel approach for cancer treatment by suppressing tumor angiogenesis and metastasis. Here, we identified inhibitors against the interaction between HIF-1α and p300 by a fluorescence polarization-based assay employing a fluorescently-labeled peptide containing the C-terminal activation domain of HIF-1α. Two small molecule inhibitors, menadione (MD) and ethacrynic acid (EA), were found to decrease expression of luciferase under the control of hypoxia-responsive elements in hypoxic cells as well as to efficiently block the interaction between the full-length HIF-1α and p300. While these compounds did not alter the expression level of HIF-1α, they down-regulated expression of a HIF-1α target vascular endothelial growth factor (VEGF) gene. Considering hypoxia-induced VEGF expression leading to highly aggressive tumor growth, MD and EA may provide new scaffolds for development of tumor therapeutic reagents as well as tools for a better understanding of HIF-1α-mediated hypoxic regulation. Copyright © 2013 Elsevier Inc. All rights reserved.

  17. Modelos cognitivos, operaciones cognitivas y usos figurados del lenguaje

    Directory of Open Access Journals (Sweden)

    Francisco José Ruiz de Mendoza Ibáñez

    2012-01-01

    Full Text Available El presente artículo está dedicado al estudio de los diferentes mecanismos cognitivos que, al operar sobre diferentes modelos cognitivos (ya sea en solitario o en combinación, dan origen a una serie de efectos de significado en el plano comunicativo. Dichos efectos constituyen lo que normalmente se conoce como usos figurados del lenguaje, tales como la ironía, la paradoja, la hipérbole, etc. Con este propósito, presentamos una taxonomía tanto de modelos como de operaciones cognitivas, atendiendo a varios criterios de clasificación. Además, proponemos una serie de principios reguladores que constriñen la actuación de las operaciones cognitivas.

  18. MODELOS COGNITIVOS, OPERACIONES COGNITIVAS Y USOS FIGURADOS DEL LENGUAJE

    Directory of Open Access Journals (Sweden)

    Francisco José Ruiz de Mendoza Ibáñez

    2012-06-01

    Full Text Available El presente artículo está dedicado al estudio de los diferentes mecanismos cognitivos que, al operar sobre diferentes modelos cognitivos (ya sea en solitario o en combinación, dan origen a una serie de efectos de significado en el plano comunicativo. Dichos efectos constituyen lo que normalmente se conoce como usos figurados del lenguaje, tales como la ironía, la paradoja, la hipérbole, etc. Con este propósito, presentamos una taxonomía tanto de modelos como de operaciones cognitivas, atendiendo a varios criterios de clasificación. Además, proponemos una serie de principios reguladores que constriñen la actuación de las operaciones cognitivas.

  19. Modelo Vectorial para la Inferencia del Estado Cognitivo de Pacientes en Estados Derivados del Coma

    Directory of Open Access Journals (Sweden)

    Esteban Velásquez R.

    2014-06-01

    Full Text Available La forma tradicional de evaluar el estado de conciencia de un individuo, ha sido mediante la aplicación de estímulos y el análisis de sus respuestas, sin embargo, esta técnica se ve limitada cuando el individuo es incapaz de responder evidentemente ante un estímulo, como es el caso de los pacientes en estados derivados del coma. En estos casos, se requiere de una conexión directa con el cerebro del paciente para detectar una respuesta. Por consiguiente, en este artículo se desarrolla y analiza un modelo computacional basado en los principios de las máquinas de soporte vectorial (MSV, para inferir el estado cognitivo de pacientes en estados derivados del coma, mediante la utilización de un equipo de electroencefalografía comercial. Los resultados obtenidos, mostraron que el modelo logró clasificar correctamente una tarea cognitiva en al menos cuatro de cada cinco pruebas en pacientes de control, lo que se traduce en la obtención de un sistema de bajo costo para el análisis del estado de conciencia y para la posible comunicación con algunos pacientes en estados derivados del coma mediante protocolos médicos definidos. De esta manera, este sistema se presenta como un gran aporte para las clínicas y centros hospitalarios, como herramienta potencial de diagnóstico para este tipo de pacientes.

  20. Distinct p300-responsive mechanisms promote caspase-dependent apoptosis by human T-cell lymphotropic virus type 1 Tax protein.

    Science.gov (United States)

    Nicot, C; Harrod, R

    2000-11-01

    The dysregulation of cellular apoptosis pathways has emerged as a critical early event associated with the development of many types of human cancers. Numerous viral and cellular oncogenes, aside from their inherent transforming properties, are known to induce programmed cell death, consistent with the hypothesis that genetic defects are required to support tumor survival. Here, we report that nuclear expression of the CREB-binding protein (CBP)/p300-binding domain of the human T-cell lymphotropic virus type 1 (HTLV-1) transactivator, Tax, triggers an apoptotic death-inducing signal during short-term clonal analyses, as well as in transient cell death assays. Coexpression of the antiapoptotic factor Bcl-2 increased serum stimulation; incubation with the chemical caspase inhibitor z-Val-Ala-DL-Asp fluoromethylketone antagonized Tax-induced cell death. The CBP/p300-binding defective Tax mutants K88A and V89A exhibited markedly reduced cytotoxic effects compared to the wild-type Tax protein. Importantly, nuclear expression of the minimal CBP/p300-binding peptide of Tax induced apoptosis in the absence of Tax-dependent transcriptional activities, while its K88A counterpart did not cause cell death. Further, Tax-mediated apoptosis was effectively prevented by ectopic expression of the p300 coactivator. We also report that activation of the NF-kappaB transcription pathway by Tax, under growth arrest conditions, results in apoptosis that occurs independent of direct Tax coactivator effects. Our results allude to a novel pivotal role for the transcriptional coactivator p300 in determining cell fate and raise the possibility that dysregulated coactivator usage may pose an early barrier to transformation that must be selectively overcome as a prerequisite for the initiation of neoplasia.

  1. Superiority of visual (verbal) vs. auditory test presentation modality in a P300-based CIT: The Complex Trial Protocol for concealed autobiographical memory detection.

    Science.gov (United States)

    Deng, Xiaohong; Rosenfeld, J Peter; Ward, Anne; Labkovsky, Elena

    2016-07-01

    This paper continues our efforts to determine which modality is best for presentation of stimuli in the P300-based concealed information test (CIT) called the Complex Trial Protocol (CTP). The first part of the CTP trial involves presentation of the key probe or irrelevant stimuli, and is followed by presentation of target (T) or non-target (NT). In Rosenfeld et al. (2015), probes and irrelevants regularly alternated modality over trials, but Ts and NTs were always visual. In the present study, (in both its experiments, EXP 1 and EXP 2), probes and irrelevants alternated modalities on successive trials, as before. In present EXP 1, Ts and NTs were always auditory, but in EXP 2, they were simultaneously auditory and visual. Probe P300 data were different in each study: In Rosenfeld et al. (2015) and EXP 2 here, the bootstrap-based detection rates based on probe-minus-irrelevant differences, significantly differed favoring visual probe and irrelevant presentation modality. In EXP 1 here, detection rates were the same for the two modalities. In Rosenfeld et al. (2015) there was no main effect of probe modality, visual vs. auditory on probe-minus-irrelevant P300 difference. There were such effects here in EXP 1 (pvisual modality. Probe P300 latencies were shorter for visual than for auditory stimuli in Rosenfeld et al. (2015), a trend specifically reversed in the present pair of studies. RT was faster for visual stimuli in the present studies. The T and NT modality appears to interact with probe/irrelevant modality, and the best protocol for detecting concealed information is with the 2015 study protocol or that of EXP 2, using visual stimulus presentation. Copyright © 2016 Elsevier B.V. All rights reserved.

  2. [The influence of cognitive-behavioral therapy on the P300 potential in children with psychogenic nonepileptic seizures and tension headache].

    Science.gov (United States)

    Stolarska-Weryńska, Urszula; Steczkowska, Małgorzata; Kaciński, Marek

    2016-01-01

    Explaining associations between neurophysiological and neuropsychological parameteres in children and improving the measurement methods would lead to a better understanding of the pathogenesis and course of psychosomatic disease. Goal: clinical assessment of the efficacy of cognitive-behavioral therapy in the treatment of psychogenic no- nepileptic seizures and tension type headaches in children. Determining the influence of cognitive behavioral therapy on the cognitive P300 potential and whether P300 parameters in children correlate with neuropsychological parameters. 20 children with nonepileptic psychogenic seizures and 30 children with tension type headaches, aged 11.3 - 17.11 years. The final diagnosis was made in the Paediatric Neurology Clinic. The P300 examination was performed before/after therapy, with/without hyperventilation. A fixed structure therapy was implemented (10 sessions, 90 minutes each), during two weeks of hospitalization or in an outpatient clinic (9 children with tension type headache). The psychological assessment comprised of temperament questionnaires, auditory and visual memory trials, executive function and attention trials, and in some cases also intelligence testing. More significant correlations were found in children with psychogenic seizures: attention parameters correlated negatively with reaction time, and this correlation tended to fade in the second examination, after psychotherapy. In children with tension type headache a statistically insignificant tendency was found of a positive correlation between those parameters. Medium P300 parameteres in this group were better. In 17/20 of children with psychogenic seizures a clinical improvement was observed, in 3 children the symptoms persisted in a 6 month follow up, but of a lower frequency. In 11/27 of chil- dren with tension headache the symptoms persisted, also with a lower frequency. cognitive-behavioral therapy is effective in the reduction of symptoms in many cases of

  3. Mediator and p300/CBP-Steroid Receptor Coactivator Complexes Have Distinct Roles, but Function Synergistically, during Estrogen Receptor α-Dependent Transcription with Chromatin Templates

    OpenAIRE

    Acevedo, Mari Luz; Kraus, W. Lee

    2003-01-01

    Ligand-dependent transcriptional activation by nuclear receptors involves the recruitment of various coactivators to the promoters of hormone-regulated genes assembled into chromatin. Nuclear receptor coactivators include histone acetyltransferase complexes, such as p300/CBP-steroid receptor coactivator (SRC), as well as the multisubunit mediator complexes (“Mediator”), which may help recruit RNA polymerase II to the promoter. We have used a biochemical approach, including an in vitro chromat...

  4. P300 amplitude variation is related to ventral striatum BOLD response during gain and loss anticipation: an EEG and fMRI experiment.

    Science.gov (United States)

    Pfabigan, Daniela M; Seidel, Eva-Maria; Sladky, Ronald; Hahn, Andreas; Paul, Katharina; Grahl, Arvina; Küblböck, Martin; Kraus, Christoph; Hummer, Allan; Kranz, Georg S; Windischberger, Christian; Lanzenberger, Rupert; Lamm, Claus

    2014-08-01

    The anticipation of favourable or unfavourable events is a key component in our daily life. However, the temporal dynamics of anticipation processes in relation to brain activation are still not fully understood. A modified version of the monetary incentive delay task was administered during separate functional magnetic resonance imaging (fMRI) and electroencephalogram (EEG) sessions in the same 25 participants to assess anticipatory processes with a multi-modal neuroimaging set-up. During fMRI, gain and loss anticipation were both associated with heightened activation in ventral striatum and reward-related areas. EEG revealed most pronounced P300 amplitudes for gain anticipation, whereas CNV amplitudes distinguished neutral from gain and loss anticipation. Importantly, P300, but not CNV amplitudes, were correlated to neural activation in the ventral striatum for both gain and loss anticipation. Larger P300 amplitudes indicated higher ventral striatum blood oxygen level dependent (BOLD) response. Early stimulus evaluation processes indexed by EEG seem to be positively related to higher activation levels in the ventral striatum, indexed by fMRI, which are usually associated with reward processing. The current results, however, point towards a more general motivational mechanism processing salient stimuli during anticipation. Copyright © 2014. Published by Elsevier Inc.

  5. Comparison of effects of valsartan and amlodipine on cognitive functions and auditory p300 event-related potentials in elderly hypertensive patients.

    Science.gov (United States)

    Katada, Eiichi; Uematsu, Norihiko; Takuma, Yuko; Matsukawa, Noriyuki

    2014-01-01

    We compared the antihypertensive effect of valsartan (VAL) and amlodipine (AML) treatments in elderly hypertensive patients by examining the long-term changes in cognitive function and auditory P300 event-related potentials. We enrolled 20 outpatients, including 12 men and 8 women in the age group of 56 to 81 years who had mild to moderate essential hypertension. The subjects were randomly allocated to receive either 80 mg VAL once a day (10 patients) or 5 mg AML once a day (10 patients). Neuropsychological assessment and auditory P300 event-related potentials were obtained before initiation of VAL or AML treatment and after 6 months of the treatment with VAL or AML. Neuropsychological assessment was evaluated by conducting the Mini-Mental State Examination, the verbal fluency, word-list memory, word-list recall test, word-list recognition, and Trails B tests. Both the groups showed significantly reduced-blood pressure after 6 months of treatment, and the intergroup difference was not significant. The mean baseline Mini-Mental State Examination scores of the VAL and AML groups were not significantly different. Amlodipine treatment did not significantly affect any test score, but VAL treatment significantly increased the word-list memory and word-list recall test scores. Valsartan, and not AML, significantly reduced the mean P300 latency after 6 months. These results suggest that VAL exerts a positive effect on cognitive functions, independent of its antihypertensive effect.

  6. A comparison of cognitive functions in non-hypoxemic chronic obstructive pulmonary disease (COPD patients and age-matched healthy volunteers using mini-mental state examination questionnaire and event-related potential, P300 analysis

    Directory of Open Access Journals (Sweden)

    Prem Parkash Gupta

    2013-01-01

    Full Text Available Objective: To assess sub-clinical cognitive dysfunctions in stable chronic obstructive pulmonary disease (COPD patients having no hypoxemia vs. age-matched healthy volunteers using (i an electrophysiological test: Auditory event related potential, P300 test and (ii a questionnaire tool: Mini-mental state examination (MMSE questionnaire. Materials and Methods: Eighty male subjects were included: 40 stable COPD patients (smoking history >20 pack years and 40 healthy volunteers (HVs. Age, duration of illness, smoking pack years, and spirometric indices were assessed. MMSE scores were evaluated in these groups. Latency of P300 wave and amplitude of P300 wave were studied in both groups to detect P300 abnormalities in COPD group. Correlations of P300 abnormalities with patient characteristic parameters and MMSE scores were assessed. In addition, individual COPD patients having significant cognitive dysfunctions beyond cut-off value of 99 th percentile of HVs were analyzed. Results: We observed significantly prolonged P300 latency ( P 0.05 for all. Conclusions: Our study explores cognitive dysfunctions in stable COPD patients with no hypoxemia. This study highlights the relative importance of using MMSE and P300. Cognitive dysfunctions were detected both by MMSE and P300; however, MMSE abnormalities were more frequent compared to P300 abnormalities (27/40 vs. 10/40 in COPD patients.

  7. La enseñanza de la lectura documentaria en el abordaje cognitivo y socio-cognitivo: orientaciones a la formación del indizador

    Directory of Open Access Journals (Sweden)

    Mariângela Spotti Lopes Fujita

    2008-02-01

    Full Text Available El indizador como lector profesional debe ser visto dentro de su contexto socio-cultural y socio-cognitivo. Se propone un análisis de los abordajes cognitivo y socio-cognitivo en Ciencias de la Información con la finalidad de fundamentar la investigación sobre el uso de estrategias de enseñanza de lectura documental para la formación inicial del indizador. Las investigaciones sobre lectura documental para la indización desarrolladas inicialmente desde aproximaciones cognitivas de observación de las tareas propias del indizador tuvieron gran importancia para el conocimiento de estrategias de la lectura profesional. Al abordar el modelo interaccionista de lectura entre las variables texto-lector-contexto, se delimita un acercamiento socio-cognitivo necesario para que el indizador, como lector, tenga una visión más amplia del contexto socio-cultural.

  8. Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway.

    Science.gov (United States)

    Zhang, Erli; Guo, Qianyun; Gao, Haiyang; Xu, Ruixia; Teng, Siyong; Wu, Yongjian

    2015-01-01

    Endothelial senescence plays crucial roles in diabetic vascular complication. Recent evidence indicated that transient hyperglycaemia could potentiate persistent diabetic vascular complications, a phenomenon known as "metabolic memory." Although SIRT1 has been demonstrated to mediate high glucose-induced endothelial senescence, whether and how "metabolic memory" would affect endothelial senescence through SIRT1 signaling remains largely unknown. In this study, we investigated the involvement of SIRT1 axis as well as the protective effects of resveratrol (RSV) and metformin (MET), two potent SIRT1 activators, during the occurrence of "metabolic memory" of cellular senescence (senescent "memory"). Human umbilical vascular endothelial cells (HUVECs) were cultured in either normal glucose (NG)/high glucose (HG) media for 6 days, or 3 days of HG followed by 3 days of NG (HN), with or without RSV or MET treatment. It was shown that HN incubation triggered persistent downregulation of deacetylase SIRT1 and upregulation of acetyltransferase p300, leading to sustained hyperacetylation (at K382) and activation of p53, and subsequent p53/p21-mediated senescent "memory." In contrast, senescent "memory" was abrogated by overexpression of SIRT1 or knockdown of p300. Interestingly, we found that SIRT1 and p300 could regulate each other in response to HN stimulation, suggesting that a delicate balance between acetyltransferases and deacetylases may be particularly important for sustained acetylation and activation of non-histone proteins (such as p53), and eventually the occurrence of "metabolic memory." Furthermore, we found that RSV or MET treatment prevented senescent "memory" by modulating SIRT1/p300/p53/p21 pathway. Notably, early and continuous treatment of MET, but not RSV, was particularly important for preventing senescent "memory." In conclusion, short-term high glucose stimulation could induce sustained endothelial senescence via SIRT1/p300/p53/p21 pathway. RVS or MET

  9. Relación entre el potencial al maltrato infantil y los estilos de afrontamiento al estrés en madres de un centro de salud de Lima

    OpenAIRE

    Condori Aguilar, Mercedes Isabel

    2017-01-01

    El modelo de procesamiento social aplicado al maltrato infantil propone que existiría relación entre los procesos cognitivos que utiliza el sujeto en su interrelación con el medio y su uso de conductas de maltrato en la relación con sus hijos. En esta investigación se analizó el rol del afrontamiento al estrés en el potencial al maltrato infantil de la madre. El diseño aplicado fue descriptivo correlacional y de carácter no experimental. Se trabajó con una muestra de madres mayores de 18 años...

  10. Acerca de los estilos cognitivos: dependencia- independencia de campo

    Directory of Open Access Journals (Sweden)

    Anibal Meza

    1987-12-01

    Full Text Available Se ofrece una breve revisión de la literatura sobre los Estilos Cognitivos de Dependencia- Independencia del Campo (De-le. Se hace notar la ausencia de investigaciones peruanas sobre el tema y se delimita al ámbito de la temática De-le. Se da cuenta del origen de la De-le como constructo, anclándolo al interior del constructo mayor "diferenciación psicológica". Se reseñan los modos de evaluación y se enlistan las características de la De-le como estilos cognitivos (son dimensiones penetrantes del funcionamiento individual, son variables de proceso antes que de contenido y constituyen una dimensión bipolar y de valor neutral. Se ven las relaciones De-le -conducta interpersonal: tipo de orientación interpersonal, responsividad a claves sociales e intereses y respuestas interpersonales típicas. Finalmente, se examinan los orígenes ontogenético (restringiendo la revisión a efectos de entrenamiento y la crianza infantil y cultural de la De-le.

  11. Clinical study on the value of combining neuropsychological tests with auditory event-related potential P300 for cognitive assessment in elderly patients with cerebral small vessel disease

    Directory of Open Access Journals (Sweden)

    Xiao-ling ZHAO

    2016-11-01

    Full Text Available Objective To investigate the value of combining neuropsychological tests with auditory event-related potential (ERP P300 for cognitive assessment in elderly patients with cerebral small vessel disease (cSVD.  Methods A total of 183 elderly patients with cSVD were enrolled in this study. They were divided into 3 groups according to brain MRI: lacunar infarct (LACI group (N = 62, white matter hyperintensity (WMH group (N = 60 and LACI + WMH group (N = 61. A total of 50 brain MRI normal persons were selected as control group. Montreal Cognitive Assessment (MoCA, Chinese version was used to evaluate the cognitive function, and the amplitude and latency of P300 were measured in each group.  Results Compared with control group, the MoCA total score in LACI, WMH and LACI + WMH groups were significantly lower (P = 0.042, 0.015, 0.000, and the score in LACI + WMH group was significantly lower than that in LACI and WMH groups (P = 0.001, 0.042. In the eight cognitive domains of MoCA scale, the visual space and executive function (P = 0.006, 0.041, 0.035, delayed memory (P = 0.006, 0.012, 0.048, language (P = 0.001, 0.032, 0.047 and calculation (P = 0.009, 0.001, 0.003 in LACI + WMH group were significantly lower than those in control, LACI and WMH groups. The delayed memory in LACI group was significantly lower than that in control group (P = 0.037. The delayed memory (P = 0.005 and language (P = 0.047 in WMH group were significantly lower than those in control group. Compared with control group, the amplitudes of P300 (P = 0.025, 0.033, 0.000 in LACI, WMH and LACI + WMH groups were significantly decreased, and the latencies (P = 0.018, 0.000, 0.000 were significantly prolonged. The amplitude of P300 in LACI + WMH group was significantly lower than that in LACI and WMH groups (P = 0.041, 0.018, and the latency was significantly prolonged (P = 0.000, 0.022.  Conclusions Elderly patients of cSVD all suffer from different degrees of cognitive impairment

  12. The E1A proteins of all six human adenovirus subgroups target the p300/CBP acetyltransferases and the SAGA transcriptional regulatory complex

    International Nuclear Information System (INIS)

    Shuen, Michael; Avvakumov, Nikita; Torchia, Joe; Mymryk, Joe S.

    2003-01-01

    The N-terminal/conserved region 1 (CR1) portion of the human adenovirus (Ad) 5 E1A protein was previously shown to inhibit growth in the simple eukaryote Saccharomyces cerevisiae. We now demonstrate that the corresponding regions of the E1A proteins of Ad3,-4,-9,-12, and -40, which represent the remaining five Ad subgroups, also inhibit yeast growth. These results suggest that the E1A proteins of all six human Ad subgroups share a common cellular target(s) conserved in yeast. Growth inhibition induced by either full-length or the N-terminal/CR1 portion of Ad5 E1A was relieved by coexpression of the E1A binding portions of the mammalian p300, CBP, and pCAF acetyltransferases. Similarly, growth inhibition by the N-terminal/CR1 portions of the other Ad E1A proteins was suppressed by expression of the same regions of CBP or pCAF known to bind Ad5 E1A. The physical interaction of each of the different Ad E1A proteins with CBP, p300, and pCAF was confirmed in vitro. Furthermore, deletion of the gene encoding yGcn5, the yeast homolog of pCAF and a subunit of the SAGA transcriptional regulatory complex, restored growth in yeast expressing each of the different Ad E1A proteins. This indicates that the SAGA complex is a conserved target of all Ad E1A proteins. Our results demonstrate for the first time that the p300, CBP, and pCAF acetyltransferases are common targets for the E1A proteins of all six human Ad subgroups, highlighting the importance of these interactions for E1A function

  13. Desempenho cognitivo em pacientes operados de aneurisma cerebral

    Directory of Open Access Journals (Sweden)

    FOBE JEAN-LUC

    1999-01-01

    Full Text Available Vinte e cinco pacientes operados de aneurisma cerebral foram submetidos a avaliação cognitiva pós operatória tardia para linguagem, praxia, orientação, lógica, compreensão, memória, depressão, demência e gnosia visual. Os resultados foram correlacionados com idade, escala de Hunt-Hess à admissão, lado, local e tamanho do aneurisma, sangue à TC (Fisher, vaso-espasmo angiográfico (George. Déficit cognitivo tardio estava ausente em 8 pacientes (32%, era leve em 5 (20%, moderado em 6 (24% e grave em 6 (24%. A função cognitiva isoladamente mais alterada foi a da lógica com acometimento moderado e grave em 7 pacientes (28%, seguida de praxia em 6 (24%, orientação em 5 (20%, linguagem e memória em 4 (16%. A alteração gnósica visual, demência e depressão foram pouco frequentes. A compreensão estava levemente alterada em 3 pacientes. Na faixa etária 25-50 anos ocorreu melhor resultado cognitivo com sequela inexistente ou leve em 9 pacientes (75%. Os aneurismas da artéria comunicante posterior direita apresentaram déficit cognitivo tardio ausente ou leve em 5 pacientes (71,42%, os da artéria cerebral média direita apresentaram resultado equivalente em 2 (66,66%. Os aneurismas de artéria cerebral média esquerda apresentaram o pior resultado com sequela cognitiva moderada e grave em 5 pacientes (71,42%. As sequelas neuropsicológicas tardias apresentaram correlação direta com a idade, Hunt-Hess, sangue à TC, vaso-espasmo angiográfico e localização anatômica do aneurisma.

  14. Escritura inicial y estilo cognitivo Initial Writing and Cognitive Style

    Directory of Open Access Journals (Sweden)

    Lida Johana Rincón Camacho

    2012-06-01

    Full Text Available Resumen Se examinaron los efectos comparados de dos métodos para la enseñanza de la escritura en el nivel inicial: global y silábico y su interacción con el estilo cognitivo en la dimensión de dependencia-independencia de campo (DIC, en 31 niños de dos grupos escolares de primer grado de primaria, de dos instituciones diferentes, en donde cada uno de los métodos de venían implementando. Se aplicaron la prueba CEFT para la determinación del estilo cognitivo y la prueba de escritura ''ejercicio de creación de texto'' al inicio del año escolar del primer grado y cuatro meses después. Los resultados finales fueron examinados a través de análisis de covarianza en los que se controlaron, como covariables, los logros registrados cuatro meses antes. Los datos muestran evidentes ventajas del método global sobre el método silábico en términos generales, y muy específicamente para los niños de estilo dependiente de campo o intermedio en seis de los ocho los indicadores examinados. Estos resultados son explicados a partir de características distintivas del estilo cognitivo en esta dimensión.Abstract Comparative effects of two methods used for teaching writing at the initial level were examined: the global and syllabic approaches and their interaction with cognitive style in the field dependence-independence dimension (FDI, in 31 first-grade children from two school groups and from two different institutions, where each one of the methods were implemented. CEFT test was applied to determine the cognitive style, and a writing test called "text-building exercise" was also used at the beginning of the academic year and four months later. The final results were esamined through covariance analysis, in which the achievements recorded four months earlier were controlled as covariates. In general, data show clear advantages of the global method over the syllabic method, specifically for field-dependent and intermediate style children in six

  15. Rasgos distintivos de la comorbilidad y funcionalidad en ancianos institucionalizados con deterioro cognitivo y demencia

    Directory of Open Access Journals (Sweden)

    Armando Carlos Roca Socarras

    2013-07-01

    Full Text Available Fundamento: altos niveles de comorbilidad y el declinar funcional están estrechamente relacionados con la mortalidad a corto plazo y la pobre calidad de vida de las personas mayores institucionalizadas. Objetivo: determinar la asociación del deterioro cognitivo con la alta comorbilidad y el declinar funcional en personas mayores institucionalizadas. Métodos: estudio descriptivo de 156 pacientes ingresados en un hogar de ancianos ubicado en Mahé, Seychelles, entre el 2010 y el 2012. Se analizó el comportamiento de los adultos mayores en relación con: presencia de deterioro cognitivo y demencia, edad, sexo, enfermedades crónicas no transmisibles, niveles de comorbilidad, declinar funcional, filtrado glomerular estimado, polifarmacia, y años de escolaridad. En la evaluación de la comorbilidad se utilizó el Índice de Charlson en su versión abreviada y en la valoración funcional el Índice de Barthel. Resultados: el 57,7 % de los residentes presentaron deterioro cognitivo o demencia, de ellos el 66,7 % pertenecieron al sexo masculino. Los pacientes con deterioro cognitivo y demencia analizados en el estudio tuvieron una mayor probabilidad de padecer alta comorbilidad (OR: 5,88; intervalo de confianza del 95% [IC95]: 5,42-6,33 y peor desempeño funcional (OR: 20,53; IC95%: 19,54-21,29 que los casos institucionalizados sin estas entidades. Otras variables estudiadas en los casos con deterioro cognitivo como la edad, presencia de polifarmacia, filtrado glomerular estimado y años de escolaridad mostraron diferencias significativas en comparación con los adultos mayores sin deterioro cognitivo. Conclusiones: los pacientes con deterioro cognitivo tienen una comorbilidad y deterioro funcional superior a los casos sin deterioro cognitivo. Se constata asociación del deterioro cognitivo con la alta comorbilidad y un peor desempeño funcional.

  16. Natural derivatives of curcumin attenuate the Wnt/β-catenin pathway through down-regulation of the transcriptional coactivator p300

    International Nuclear Information System (INIS)

    Ryu, Min-Jung; Cho, Munju; Song, Jie-Young; Yun, Yeon-Sook; Choi, Il-Whan; Kim, Dong-Eun; Park, Byeoung-Soo; Oh, Sangtaek

    2008-01-01

    Curcumin, a component of turmeric (Curcuma longa), has been reported to suppress β-catenin response transcription (CRT), which is aberrantly activated in colorectal cancer. However, the effects of its natural analogs (demethoxycurcumin [DMC] and bisdemethoxycurcumin [BDMC]) and metabolite (tetrahydrocurcumin [THC]) on the Wnt/β-catenin pathway have not been investigated. Here, we show that DMC and BDMC suppressed CRT that was activated by Wnt3a conditioned-medium (Wnt3a-CM) without altering the level of intracellular β-catenin, and inhibited the growth of various colon cancer cells, with comparable potency to curcumin. Additionally, DMC and BDMC down-regulated p300, which is a positive regulator of the Wnt/β-catenin pathway. Notably, THC also inhibited CRT and cell proliferation, but to a much lesser degree than curcumin, DMC, or BDMC, indicating that the conjugated bonds in the central seven-carbon chain of curcuminoids are essential for the inhibition of Wnt/β-catenin pathway and the anti-proliferative activity of curcuminoids. Thus, our findings suggest that curcumin derivatives inhibit the Wnt/β-catenin pathway by decreasing the amount of the transcriptional coactivator p300.

  17. Reciprocal occupancy of BCL6 and STAT5 on Growth Hormone target genes: contrasting transcriptional outcomes and promoter-specific roles of p300 and HDAC3.

    Science.gov (United States)

    Lin, Grace; LaPensee, Christopher R; Qin, Zhaohui S; Schwartz, Jessica

    2014-09-01

    Expression of the Growth Hormone (GH)-stimulated gene Socs2 (Suppressor of Cytokine Signaling 2) is mediated by the transcription activator STAT5 (Signal Transducer and Activator of Transcription 5) and the transcription repressor BCL6 (B-Cell Lymphoma 6). ChIP-Sequencing identified Cish (Cytokine-Inducible SH2-containing protein) and Bcl6 as having similar patterns of reciprocal occupancy by BCL6 and STAT5 in response to GH, though GH stimulates Cish and inhibits Bcl6 expression. The co-activator p300 occupied Socs2, Cish and Bcl6 promoters, and enhanced STAT5-mediated activation of Socs2 and Cish. In contrast, on Bcl6, p300 functioned as a repressor and inhibited in conjunction with STAT5 or BCL6. The co-repressor HDAC3 (Histone deacetylase 3) inhibited the Socs2, Cish and Bcl6 promoters in the presence of STAT5. Thus transcriptional outcomes on GH-regulated genes occupied by BCL6 and STAT5 are determined in a promoter-specific fashion by co-regulatory proteins which mediate the distinction between activating and repressive transcription factors. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  18. The effects of sweep numbers per average and protocol type on the accuracy of the p300-based concealed information test.

    Science.gov (United States)

    Dietrich, Ariana B; Hu, Xiaoqing; Rosenfeld, J Peter

    2014-03-01

    In the first of two experiments, we compared the accuracy of the P300 concealed information test protocol as a function of numbers of trials experienced by subjects and ERP averages analyzed by investigators. Contrary to Farwell et al. (Cogn Neurodyn 6(2):115-154, 2012), we found no evidence that 100 trial based averages are more accurate than 66 or 33 trial based averages (all numbers led to accuracies of 84-94 %). There was actually a trend favoring the lowest trial numbers. The second study compared numbers of irrelevant stimuli recalled and recognized in the 3-stimulus protocol versus the complex trial protocol (Rosenfeld in Memory detection: theory and application of the concealed information test, Cambridge University Press, New York, pp 63-89, 2011). Again, in contrast to expectations from Farwell et al. (Cogn Neurodyn 6(2):115-154, 2012), there were no differences between protocols, although there were more irrelevant stimuli recognized than recalled, and irrelevant 4-digit number group stimuli were neither recalled nor recognized as well as irrelevant city name stimuli. We therefore conclude that stimulus processing in the P300-based complex trial protocol-with no more than 33 sweep averages-is adequate to allow accurate detection of concealed information.

  19. Visual stimuli for the P300 brain-computer interface: a comparison of white/gray and green/blue flicker matrices.

    Science.gov (United States)

    Takano, Kouji; Komatsu, Tomoaki; Hata, Naoki; Nakajima, Yasoichi; Kansaku, Kenji

    2009-08-01

    The white/gray flicker matrix has been used as a visual stimulus for the so-called P300 brain-computer interface (BCI), but the white/gray flash stimuli might induce discomfort. In this study, we investigated the effectiveness of green/blue flicker matrices as visual stimuli. Ten able-bodied, non-trained subjects performed Alphabet Spelling (Japanese Alphabet: Hiragana) using an 8 x 10 matrix with three types of intensification/rest flicker combinations (L, luminance; C, chromatic; LC, luminance and chromatic); both online and offline performances were evaluated. The accuracy rate under the online LC condition was 80.6%. Offline analysis showed that the LC condition was associated with significantly higher accuracy than was the L or C condition (Tukey-Kramer, p < 0.05). No significant difference was observed between L and C conditions. The LC condition, which used the green/blue flicker matrix was associated with better performances in the P300 BCI. The green/blue chromatic flicker matrix can be an efficient tool for practical BCI application.

  20. Contradição e crise no capitalismo cognitivo

    Directory of Open Access Journals (Sweden)

    Francisco Javier Moreno Gálvez

    2016-12-01

    Full Text Available Na reestruturação do capitalismo que foi produzido nos anos 1970, as novas tecnologias da informação e comunicação tiveram um papel fundamental ao permitir uma utilização intensiva do conhecimento, um papel que podemos rastrear em suas continuidades até os dias atuais. Nas últimas décadas assistimos ao desenvolvimento de uma tensão entre a tendência à privatização, própria do capitalismo cognitivo, e a tendência democratizadora da economia social do conhecimento. O presente artigo trata de analisar tal tensão apontando suas consequências para os modelos de desenvolvimento que entram em disputa no atual contexto global.

  1. MICROALGAS E SEU POTENCIAL DE USO

    OpenAIRE

    Barcellos, Amanda Desireux; UFBA; Barreto, Antonio Geraldo da Silva Sá; UFBA; Machado, Bruna Aparecida Souza; UFBA; Druzian, Janice Izabel; UFBA

    2014-01-01

    As microalgas são organismos predominantemente microscópicos unicelulares, procariontes ou eucariontes, dotados de pigmentos e fotoautotróficos. Estes seres possuem um alto potencial biológico, ecológico e econômico. O objetivo desta prospecção tecnológica foi identificar as patentes, teses e artigos científicos referentes a microalgas quanto ao seu emprego nos mais diversos setores, bem como sua tecnologia de cultivo. Para tanto, foi realizada uma pesquisa aos bancos de dados de patentes nac...

  2. Estilo cognitivo predominante en estudiantes universitarios de terapia ocupacional de la Universidad Nacional de Colombia 2009

    Directory of Open Access Journals (Sweden)

    Fabiola Becerra Bulla

    2012-01-01

    Conclusiones. En este estudio predominó el estilo cognitivo intermedio, es decir con rasgos de ambas polaridades; en menor proporción se encontraron estudiantes  totalmente dependientes o independientes de campo.

  3. DIABETES MELLITUS Y SU ASOCIACIÓN CON DETERIORO COGNITIVO Y DEMENCIA

    Directory of Open Access Journals (Sweden)

    DR. Gonzalo Muñoz A.

    2016-03-01

    Se han descrito alteraciones en todos los dominios cognitivos, sin embargo velocidad psicomotora y atención son los más comúnmente vinculados a la diabetes. Concluimos que la diabetes tiene como órgano blanco el cerebro y enfatizamos la importancia del estudio neuropsicológico en pacientes con larga historia de la enfermedad y en aquellos donde pudiera existir un trastorno cognitivo que puede condicionar la adherencia al tratamiento.

  4. Efeito de uma intervenção cognitivo-motora sobre os sintomas depressivos de pacientes com doença de Parkinson

    Directory of Open Access Journals (Sweden)

    Gustavo Christofoletti

    2012-01-01

    Full Text Available OBJETIVO: Verificar a eficácia de uma intervenção cognitivo-motora sobre os sintomas depressivos de pacientes com DP idiopática. MÉTODOS: Foi realizado um estudo longitudinal, composto por 26 pacientes, divididos entre os grupos experimental e controle. Os sujeitos foram avaliados pela Escala de Depressão Geriátrica, sendo o grupo experimental submetido a uma sequência de exercícios fisioterápicos de estimulação cognitivo-motora durante seis meses. Para a análise dos dados, foram aplicados os testes de Análise de Variâncias para medidas repetidas, a estatística por contraste e o teste t de Student para amostras independentes, sob um nível de significância de 5%. RESULTADOS: Os resultados apontaram homogeneidade dos grupos no momento inicial, e o grupo submetido ao tratamento fisioterápico obteve uma tendência de significância na interação "momento de intervenção" versus "grupo", evidenciado pelo erro alfa de 6%, com contraste linear de dados. CONCLUSÃO: O protocolo proposto apresentou boa aceitação pelos pacientes com DP. Apesar de não termos alcançado um intervalo de confiança de 95%, a tendência de significância obtida vislumbra um potencial do referido protocolo, mas com a necessidade de maiores estudos comprobatórios.

  5. El mapa cognitivo en los procesos de evaluación del aprendizaje

    Directory of Open Access Journals (Sweden)

    William R. Avendaño C.

    2012-07-01

    Full Text Available En este artículo se hace una revisión del mapa cognitivo de Reuven Feuerstein como instrumento de evaluación. El objetivo de este artículo, por lo tanto, es el análisis del mapa cognitivo en el marco de la evaluación, las ciencias cognitivas y su pertinencia como herramienta de uso en el aula de clase. Metodología: para el logro de ese objetivo se hizo una amplia revisión de la literatura en torno de la evaluación, la práctica de la calificación, los aportes de las ciencias cognitivas y los avances de la neurociencia, para concluir con el mapa cognitivo y un diseño propuesto para la sistematización de la información de acuerdo con los elementos del mapa cognitivo planteado por Feuerstein. Conclusiones: El mapa cognitivo es una herramienta de evaluación que responde a las necesidades de los estudiantes y al marco conceptual definido y aceptado por la comunidad académica. Las ventajas operativas del mapa cognitivo son evidentes a la luz de los avances del funcionamiento del cerebro y la mente en los procesos de aprendizaje.

  6. El mapa cognitivo en los procesos de evaluación del aprendizaje

    Directory of Open Access Journals (Sweden)

    William R. Avendaño C.

    2012-01-01

    Full Text Available En este artículo se hace una revisión del mapa cognitivo de Reuven Feuerstein como instrumento de evaluación. El objetivo de este artículo, por lo tanto, es el análisis del mapa cognitivo en el marco de la evaluación, las ciencias cognitivas y su pertinencia como herramienta de uso en el aula de clase. Metodología: para el logro de ese objetivo se hizo una amplia revisión de la literatura en torno de la evaluación, la práctica de la calificación, los aportes de las ciencias cognitivas y los avances de la neurociencia, para concluir con el mapa cognitivo y un diseño propuesto para la sistematización de la información de acuerdo con los elementos del mapa cognitivo planteado por Feuerstein. Conclusiones: El mapa cognitivo es una herramienta de evaluación que responde a las necesidades de los estudiantes y al marco conceptual definido y aceptado por la comunidad académica. Las ventajas operativas del mapa cognitivo son evidentes a la luz de los avances del funcionamiento del cerebro y la mente en los procesos de aprendizaje.

  7. IFNγ Induces DNA Methylation-Silenced GPR109A Expression via pSTAT1/p300 and H3K18 Acetylation in Colon Cancer.

    Science.gov (United States)

    Bardhan, Kankana; Paschall, Amy V; Yang, Dafeng; Chen, May R; Simon, Priscilla S; Bhutia, Yangzom D; Martin, Pamela M; Thangaraju, Muthusamy; Browning, Darren D; Ganapathy, Vadivel; Heaton, Christopher M; Gu, Keni; Lee, Jeffrey R; Liu, Kebin

    2015-07-01

    Short-chain fatty acids, metabolites produced by colonic microbiota from fermentation of dietary fiber, act as anti-inflammatory agents in the intestinal tract to suppress proinflammatory diseases. GPR109A is the receptor for short-chain fatty acids. The functions of GPR109A have been the subject of extensive studies; however, the molecular mechanisms underlying GPR109A expression is largely unknown. We show that GPR109A is highly expressed in normal human colon tissues, but is silenced in human colon carcinoma cells. The GPR109A promoter DNA is methylated in human colon carcinoma. Strikingly, we observed that IFNγ, a cytokine secreted by activated T cells, activates GPR109A transcription without altering its promoter DNA methylation. Colon carcinoma grows significantly faster in IFNγ-deficient mice than in wild-type mice in an orthotopic colon cancer mouse model. A positive correlation was observed between GPR109A protein level and tumor-infiltrating T cells in human colon carcinoma specimens, and IFNγ expression level is higher in human colon carcinoma tissues than in normal colon tissues. We further demonstrated that IFNγ rapidly activates pSTAT1 that binds to the promoter of p300 to activate its transcription. p300 then binds to the GPR109A promoter to induce H3K18 hyperacetylation, resulting in chromatin remodeling in the methylated GPR109A promoter. The IFNγ-activated pSTAT1 then directly binds to the methylated but hyperacetylated GPR109 promoter to activate its transcription. Overall, our data indicate that GPR109A acts as a tumor suppressor in colon cancer, and the host immune system might use IFNγ to counteract DNA methylation-mediated GPR109A silencing as a mechanism to suppress tumor development. ©2015 American Association for Cancer Research.

  8. IFNγ induces DNA methylation-silenced GPR109A expression via pSTAT1/p300 and H3K18 acetylation in colon cancer

    Science.gov (United States)

    Bardhan, Kankana; Paschall, Amy V.; Yang, Dafeng; Chen, May R.; Simon, Priscilla S.; Bhutia, Yangzom; Martin, Pamela M.; Thangaraju, Muthusamy; Browning, Darren D.; Ganapathy, Vadivel; Heaton, Christopher M.; Gu, Keni; Lee, Jeffrey R.; Liu, Kebin

    2015-01-01

    Short-chain fatty acids, metabolites produced by colonic microbiota from fermentation of dietary fiber, act as anti-inflammatory agents in the intestinal tract to suppress proinflammatory diseases. GPR109A is the receptor for short-chain fatty acids. The functions of GPR109A has been the subject of extensive studies, however, the molecular mechanisms underlying GPR109A expression is largely unknown. We show that GPR109A is highly expressed in normal human colon tissues, but is silenced in human colon carcinoma cells. The GPR109A promoter DNA is methylated in human colon carcinoma. Strikingly, we observed that IFNγ, a cytokine secreted by activated T cells, activates GPR109A transcription without altering its promoter DNA methylation. Colon carcinoma grows significantly faster in IFNγ-deficient mice than in wildtype mice in an orthotopic colon cancer mouse model. A positive correlation was observed between GPR109A protein level and tumor-infiltrating T cells in human colon carcinoma specimens, and IFNγ expression level is higher in human colon carcinoma tissues than in normal colon tissues. We further demonstrated that IFNγ rapidly activates pSTAT1 that binds to the promoter of p300 to activate its transcription. p300 then binds to the GPR109A promoters to induce H3K18 hyperacetylation, resulting in chromatin remodeling in the methylated GPR109A promoter. The IFNγ-activated pSTAT1 then directly binds to the methylated but hyperacetylated GPR109 promoters to activate its transcription. Overall, our data indicate that GPR109A acts as a tumor suppressor in colon cancer and the host immune system might use IFNγ to counteract DNA methylation-mediated GPR109A silencing as a mechanism to suppress tumor development. PMID:25735954

  9. Melatonin enhances the anti-tumor effect of fisetin by inhibiting COX-2/iNOS and NF-κB/p300 signaling pathways.

    Directory of Open Access Journals (Sweden)

    Canhui Yi

    Full Text Available Melatonin is a hormone identified in plants and pineal glands of mammals and possesses diverse physiological functions. Fisetin is a bio-flavonoid widely found in plants and exerts antitumor activity in several types of human cancers. However, the combinational effect of melatonin and fisetin on antitumor activity, especially in melanoma treatment, remains unclear. Here, we tested the hypothesis that melatonin could enhance the antitumor activity of fisetin in melanoma cells and identified the underlying molecular mechanisms. The combinational treatment of melanoma cells with fisetin and melatonin significantly enhanced the inhibitions of cell viability, cell migration and clone formation, and the induction of apoptosis when compared with the treatment of fisetin alone. Moreover, such enhancement of antitumor effect by melatonin was found to be mediated through the modulation of the multiply signaling pathways in melanoma cells. The combinational treatment of fisetin with melatonin increased the cleavage of PARP proteins, triggered more release of cytochrome-c from the mitochondrial inter-membrane, enhanced the inhibition of COX-2 and iNOS expression, repressed the nuclear localization of p300 and NF-κB proteins, and abrogated the binding of NF-κB on COX-2 promoter. Thus, these results demonstrated that melatonin potentiated the anti-tumor effect of fisetin in melanoma cells by activating cytochrome-c-dependent apoptotic pathway and inhibiting COX-2/iNOS and NF-κB/p300 signaling pathways, and our study suggests the potential of such a combinational treatment of natural products in melanoma therapy.

  10. Melatonin Enhances the Anti-Tumor Effect of Fisetin by Inhibiting COX-2/iNOS and NF-κB/p300 Signaling Pathways

    Science.gov (United States)

    Yu, Zhenlong; Xiao, Yao; Wang, Jingshu; Qiu, Huijuan; Yu, Wendan; Tang, Ranran; Yuan, Yuhui; Guo, Wei; Deng, Wuguo

    2014-01-01

    Melatonin is a hormone identified in plants and pineal glands of mammals and possesses diverse physiological functions. Fisetin is a bio-flavonoid widely found in plants and exerts antitumor activity in several types of human cancers. However, the combinational effect of melatonin and fisetin on antitumor activity, especially in melanoma treatment, remains unclear. Here, we tested the hypothesis that melatonin could enhance the antitumor activity of fisetin in melanoma cells and identified the underlying molecular mechanisms. The combinational treatment of melanoma cells with fisetin and melatonin significantly enhanced the inhibitions of cell viability, cell migration and clone formation, and the induction of apoptosis when compared with the treatment of fisetin alone. Moreover, such enhancement of antitumor effect by melatonin was found to be mediated through the modulation of the multiply signaling pathways in melanoma cells. The combinational treatment of fisetin with melatonin increased the cleavage of PARP proteins, triggered more release of cytochrome-c from the mitochondrial inter-membrane, enhanced the inhibition of COX-2 and iNOS expression, repressed the nuclear localization of p300 and NF-κB proteins, and abrogated the binding of NF-κB on COX-2 promoter. Thus, these results demonstrated that melatonin potentiated the anti-tumor effect of fisetin in melanoma cells by activating cytochrome-c-dependent apoptotic pathway and inhibiting COX-2/iNOS and NF-κB/p300 signaling pathways, and our study suggests the potential of such a combinational treatment of natural products in melanoma therapy. PMID:25000190

  11. Processos cognitivos e plasticidade cerebral na Síndrome de Down Cognitive processes and brain plasticity in Down Syndrome

    Directory of Open Access Journals (Sweden)

    Maria de Fátima Minetto Caldeira Silva

    2006-04-01

    Full Text Available muito tem se falado sobre a Síndrome de Down. Mas um ponto se destaca: suas dificuldades cognitivas. Quais as áreas mais afetadas? Como potencializá-las? Essas são perguntas que instigam muitos pesquisadores. Com a efetivação da inclusão escolar, ampliaram-se as buscas por respostas, uma vez que, nas últimas décadas, ficou evidente que pessoas com Síndrome de Down têm potencial cognitivo a desenvolver. Deixamos claro aqui que não estamos negando a constatação de lesões em função de alterações genéticas, mas a possibilidade de minimizá-las. Esse artigo tem o intuito de abordar e discutir algumas das descobertas relacionadas aos processos cognitivos na Síndrome de Down, procurando evidenciar a importância da plasticidade cerebral no desenvolvimento e na aquisição da aprendizagem. Assim, procuraremos fazer um apanhado dos processos cognitivos na Síndrome de Down, correlacionando-os com os conceitos gerais de plasticidade cerebral e verificar como esses conhecimentos podem favorecer a aprendizagem. Temos plena consciência de que não esgotaremos o tema, mas pretendemos iniciar uma reflexão. Para isso, faremos uma revisão de literatura, contemplando as pesquisas, desde as mais antigas até as mais recentes, numa tentativa de entender melhor como fazer uso dessas descobertas.much has been said about Down Syndrome. But one aspect stands out: their cognitive difficulties. Which areas are most affected? How can they be enhanced? Such questions have instigated many researchers. As inclusion in the schools is being achieved, such issues have augmented the search for answers, since, during the last decades have shown that people with Down Syndrome do have cognitive potential to develop. We would like to point out at this time that we don't intend to deny the evidence of real lesions due to genetic alterations, but rather to highlight the possibility of minimizing their negative effect. The aim of this article is to address and

  12. Hipertensión arterial, menopausia y compromiso cognitivo

    Directory of Open Access Journals (Sweden)

    Mildren del Sueldo

    2018-01-01

    Full Text Available Resumen: La enfermedad cardiovascular es la primera causa de mortalidad en la mujer en la mayor parte del mundo y pese a esta realidad el riesgo de padecerla continúa siendo subestimado en mujeres. La hipertensión arterial es uno de los principales determinantes de este riesgo y su prevalencia ha incrementado de manera global, especialmente en mujeres después de los 60 años. Si bien la disminución o pérdida de los estrógenos tiene impacto sobre la regulación de la presión arterial, el papel de la menopausia en la patogénesis de la hipertensión arterial durante este período, es controversial. El daño vascular cerebral secundario a hipertensión arterial incrementa el riesgo de desarrollar deterioro cognitivo y/o demencia. La mujer es más susceptible a este daño, dada su mayor expectativa de vida aunada a la pérdida de la acción neuroprotectora de los estrógenos. Esta revisión pretende demostrar los vínculos entre la hipertensión arterial, la menopausia y el compromiso cognitivo en la mujer. Abstract: Cardiovascular Disease (CVD is the first cause of mortality in women in most parts of the world. In spite of this fact, the risk of CVD is still underestimated in women. Hypertension (HTN is one of the main determinants of this risk, and its prevalence has been increasing worldwide, especially in women over the age of 60. Even though the decrease or loss of estrogens has an impact on blood pressure (BP regulation, the role of menopause in the pathogenesis of HTN during this period is controversial. Vascular brain damage secondary to HTN increases the risk of cognitive impairment (CI and/or dementia. Women are more susceptible to these damages due to their longer life expectancy, together with the loss of the neuroprotective effects of estrogens. This review intends to show the relationships between HTN, menopause and CI in women. Palabras clave: Hipertensión arterial, Enfermedad cardiovascular, Mujer, Keywords: Arterial

  13. Potencial ornamental de acessos de pimenta

    Directory of Open Access Journals (Sweden)

    Leane Fialho de Melo

    2014-11-01

    Full Text Available O objetivo deste trabalho foi avaliar o potencial ornamental de dez acessos de pimenta Capsicum spp. procedentes da Coleção de Germoplasma da Universidade Federal do Piauí, Brasil. O experimento foi conduzido em casa de vegetação, no Departamento de Fitotecnia, do Centro de Ciências Agrárias, no município de Teresina, Piauí, obedecendo ao delineamento experimental inteiramente casualizado, com três repetições. Na caracterização morfoagronômica dos acessos, conforme orientação do Bioversity International, utilizaram-se os seguintes descritores qualitativos e quantitativos para o gênero Capsicum: forma da folha, hábito de crescimento da planta, antocianina no nó da planta, posição da flor, cor da corola, cor do fruto no estado intermediário e maduro, forma do fruto, forma do ápice do fruto, textura da epiderme do fruto, comprimento do fruto, comprimento do pedicelo, persistência do fruto maduro e altura da planta. Dentre os dez acessos avaliados, sete foram considerados com potencial ornamental: CGC-06 (C. chinense, CGC-07 (C. chinense, CGC-11 (C. annuum var. glabriusculum, CGC-23 (C. chinense, CGC-36 (C. annuum var. glabriusculum, CGC-59 (C. annuum var. glabriusculum e CGC-67 (C. annuum var. glabriusculum. O CGC 11 apresentou estética mais harmoniosa, com flores eretas, as quais são de fácil percepção; frutos eretos e vistosos e folhas de formato lanceolado.

  14. Desarrollo cognitivo diferencial e intervención psicoeducativa

    Directory of Open Access Journals (Sweden)

    Sylvia Sastre i Riba

    2013-05-01

    Full Text Available En este artículo se revisa el concepto de desarrollo cognitivo desde una perspectiva neuroconstructivista actual y sus relaciones con la intervención psicoeduca-tiva. Desde esta perspectiva se postula que, para apresar el desarrollo en toda su ampli-tud multimodal, hay que atender al menos, a dos ejes: 1 el díferencial y, 2 la interacción (simétrica o asímétrica como fenómenos incidentes de forma específica en cada uno de los cursos de desarrollo alternativos que se contemplan: la deficiencia menta! (y dentro de ella el Síndrome de Down y las altas capacidades (y, dentro de ellas, la superdota-ción, postulando la necesidad de una intervención psicoeducativa ajustada a sus parti-cularidades, sin referencias anquilosantes provenientes de la perspectiva normativa = We propose a revision of the concept of cognitive development from a neuroconstructivist point of view and their relations with the psicoeducational practices. From this point of view, we postule that we must adopt two guide-lines in order to know as large as possible the concept of development: 1, the differential one, and, 2. interac-tion (symmetrical or asymmetrical as specific phenomenon in mental deficiency (con-cretely in Down's Syndrome ones and high intellectual abilities (concretely, giftedness. We postulate the necessity of a psicoeducational intervention adjusted to their capabili-ties and necessities without inmovilisms

  15. 躯体形式障碍患者认知功能与事件相关电位P300的研究%The relationship between cognitive functions and event related potentials P300 in patients with somatoform disorders

    Institute of Scientific and Technical Information of China (English)

    谢国军; 罗伟森; 赵长江; 李晓玲; 黎雪松

    2013-01-01

    Objective: To investigate the cognitive functions and its relationship with event related potentials P300 in patients with somatoform disorders. Method: 120 cases of patients with somatoform disorders and 60 normal controls were examined P300 and the Ravens standard progressive matrices test,digit span and digit symbol test of China revised Wechsler adult intelligence scale,and the results were compared. Results; For somatoform disorders,Raven reasoning,digit span,digit symbol scores were significantly lower than the controls (P <0.01) ;event related potentials Nl ,P2,P3 latencies were significantly longer than the controls(P < 0.01 or P < 0.05) , Nl N2, N2P2, P2P3 amplitudes were significantly lower than the controls ( P < 0. 01 or P < 0.05) ;Raven reasoning scores were positively correlated with Nl latencys; digit span scores were positively correlated with P2,N2 latencys and negatively correlated with N1N2 amplitudes;digit symbol scores were positively correlated with N1N2,P2P3 amplitudes and negatively correlated with N2P3 amplitudes. Conclusion:The cognitive deficits range is wide, different P300 components may reflect different cognitive impairments in patients with somatoform disorders.%目的:探讨躯体形式障碍患者的认知功能状况及其与P300的关系. 方法:对120例躯体形式障碍患者及60例正常对照组分别进行P300检测和瑞文标准推理测验、数字广度与数字符号测验,并对结果进行比较. 结果:躯体形式障碍组的瑞文推理、数字广度、数字符号分数均低于对照组,差异有统计学意义(P<0.01);N1、P2、P3潜伏期较对照组延长,N1N2、N2P2、P2P3波幅低于对照组,差异有统计学意义(P<0.01或P<0.05);瑞文推理分数与N1潜伏期正相关;数字广度分数与P2潜伏期、N2潜伏期正相关,与N1N2波幅负相关;数字符号分数与N1N2波幅、P2P3波幅正相关,与N2P3波幅负相关. 结论:躯体形式障碍患者的认知功能缺陷范围较广,不同的P

  16. P300-based brain-computer interface (BCI) event-related potentials (ERPs): People with amyotrophic lateral sclerosis (ALS) vs. age-matched controls.

    Science.gov (United States)

    McCane, Lynn M; Heckman, Susan M; McFarland, Dennis J; Townsend, George; Mak, Joseph N; Sellers, Eric W; Zeitlin, Debra; Tenteromano, Laura M; Wolpaw, Jonathan R; Vaughan, Theresa M

    2015-11-01

    Brain-computer interfaces (BCIs) aimed at restoring communication to people with severe neuromuscular disabilities often use event-related potentials (ERPs) in scalp-recorded EEG activity. Up to the present, most research and development in this area has been done in the laboratory with young healthy control subjects. In order to facilitate the development of BCI most useful to people with disabilities, the present study set out to: (1) determine whether people with amyotrophic lateral sclerosis (ALS) and healthy, age-matched volunteers (HVs) differ in the speed and accuracy of their ERP-based BCI use; (2) compare the ERP characteristics of these two groups; and (3) identify ERP-related factors that might enable improvement in BCI performance for people with disabilities. Sixteen EEG channels were recorded while people with ALS or healthy age-matched volunteers (HVs) used a P300-based BCI. The subjects with ALS had little or no remaining useful motor control (mean ALS Functional Rating Scale-Revised 9.4 (±9.5SD) (range 0-25)). Each subject attended to a target item as the items in a 6×6 visual matrix flashed. The BCI used a stepwise linear discriminant function (SWLDA) to determine the item the user wished to select (i.e., the target item). Offline analyses assessed the latencies, amplitudes, and locations of ERPs to the target and non-target items for people with ALS and age-matched control subjects. BCI accuracy and communication rate did not differ significantly between ALS users and HVs. Although ERP morphology was similar for the two groups, their target ERPs differed significantly in the location and amplitude of the late positivity (P300), the amplitude of the early negativity (N200), and the latency of the late negativity (LN). The differences in target ERP components between people with ALS and age-matched HVs are consistent with the growing recognition that ALS may affect cortical function. The development of BCIs for use by this population may begin

  17. Memoria, funciones ejecutivas y deterioro cognitivo en población anciana

    Directory of Open Access Journals (Sweden)

    Yolanda Clemente

    2015-08-01

    Full Text Available Las funciones cognitivas hacen referencia a las funciones intelectivas o funciones mentales superiores. Suelen ser estos procesos los que primero sufren deterioro cognitivo asociado a la edad. El objetivo del presente estudio fue: analizar el estado de la memoria y las funciones ejecutivas en población anciana con y sin deterioro cognitivo; y comparar el estado cognitivo entre ancianos de un centro de personas mayores y ancianos en sus hogares. Se administró un test de screening para comprobar el nivel de deterioro cognitivo (Mini Examen Cognoscitivo MEC-35, para posteriormente, aplicar el Test de Alteración de Memoria (T@M y el Test de las Anillas. Los participantes fueron 24 sujetos, de los cuales 12 pertenecían a un centro de personas mayores y 12 residían en sus hogares. La edad media de los participantes fue de 78 años. El estudio permitió determinar la relación significativa entre el nivel de deterioro cognitivo y el estado de la memoria y las funciones ejecutivas. El sexo fue indiferente en la variable memoria, pero no en funciones ejecutivas. Finalmente, el hecho de que la persona resida en una institución no mostró diferencias significativas frente a aquellos que residen en sus hogares en cuanto al estado de la memoria y las funciones ejecutivas.

  18. The Feedback-Related Negativity and the P300 Brain Potential Are Sensitive to Price Expectation Violations in a Virtual Shopping Task.

    Science.gov (United States)

    Schaefer, Alexandre; Buratto, Luciano G; Goto, Nobuhiko; Brotherhood, Emilie V

    A large body of evidence shows that buying behaviour is strongly determined by consumers' price expectations and the extent to which real prices violate these expectations. Despite the importance of this phenomenon, little is known regarding its neural mechanisms. Here we show that two patterns of electrical brain activity known to index prediction errors-the Feedback-Related Negativity (FRN) and the feedback-related P300 -were sensitive to price offers that were cheaper than participants' expectations. In addition, we also found that FRN amplitude time-locked to price offers predicted whether a product would be subsequently purchased or not, and further analyses suggest that this result was driven by the sensitivity of the FRN to positive price expectation violations. This finding strongly suggests that ensembles of neurons coding positive prediction errors play a critical role in real-life consumer behaviour. Further, these findings indicate that theoretical models based on the notion of prediction error, such as the Reinforcement Learning Theory, can provide a neurobiologically grounded account of consumer behavior.

  19. The Feedback-Related Negativity and the P300 Brain Potential Are Sensitive to Price Expectation Violations in a Virtual Shopping Task

    Science.gov (United States)

    Schaefer, Alexandre; Buratto, Luciano G.; Goto, Nobuhiko; Brotherhood, Emilie V.

    2016-01-01

    A large body of evidence shows that buying behaviour is strongly determined by consumers’ price expectations and the extent to which real prices violate these expectations. Despite the importance of this phenomenon, little is known regarding its neural mechanisms. Here we show that two patterns of electrical brain activity known to index prediction errors–the Feedback-Related Negativity (FRN) and the feedback-related P300 –were sensitive to price offers that were cheaper than participants’ expectations. In addition, we also found that FRN amplitude time-locked to price offers predicted whether a product would be subsequently purchased or not, and further analyses suggest that this result was driven by the sensitivity of the FRN to positive price expectation violations. This finding strongly suggests that ensembles of neurons coding positive prediction errors play a critical role in real-life consumer behaviour. Further, these findings indicate that theoretical models based on the notion of prediction error, such as the Reinforcement Learning Theory, can provide a neurobiologically grounded account of consumer behavior. PMID:27658301

  20. Toward a P300 based Brain-Computer Interface for aphasia rehabilitation after stroke: Presentation of theoretical considerations and a pilot feasibility study

    Directory of Open Access Journals (Sweden)

    Sonja C Kleih

    2016-11-01

    Full Text Available People with post-stroke motor aphasia know what they would like to say but cannot express it through motor pathways due to disruption of cortical circuits. We present a theoretical background for our hypothesized connection between attention and aphasia rehabilitation and suggest why in this context, Brain-Computer Interfaces (BCI use might be beneficial for patients diagnosed with aphasia. Not only could BCI technology provide a communication tool, it might support neuronal plasticity by activating language circuits and thereby boost aphasia recovery. However, stroke may lead to heterogeneous symptoms that might hinder BCI use which is why the feasibility of this approach needed to be investigated first. In this pilot study, we included five participants diagnosed with post-stroke aphasia. Four participants were initially unable to use the visual P300 speller paradigm. By adjusting the paradigm to their needs, all participants could successfully learn to use the speller for communication with accuracies up to 100%. We describe necessary adjustments to the paradigm and present future steps to further investigate the here presented approach.

  1. Classification of EEG-P300 Signals Extracted from Brain Activities in BCI Systems Using ν-SVM and BLDA Algorithms

    Directory of Open Access Journals (Sweden)

    Ali MOMENNEZHAD

    2014-06-01

    Full Text Available In this paper, a linear predictive coding (LPC model is used to improve classification accuracy, convergent speed to maximum accuracy, and maximum bitrates in brain computer interface (BCI system based on extracting EEG-P300 signals. First, EEG signal is filtered in order to eliminate high frequency noise. Then, the parameters of filtered EEG signal are extracted using LPC model. Finally, the samples are reconstructed by LPC coefficients and two classifiers, a Bayesian Linear discriminant analysis (BLDA, and b the υ-support vector machine (υ-SVM are applied in order to classify. The proposed algorithm performance is compared with fisher linear discriminant analysis (FLDA. Results show that the efficiency of our algorithm in improving classification accuracy and convergent speed to maximum accuracy are much better. As example at the proposed algorithms, respectively BLDA with LPC model and υ-SVM with LPC model with8 electrode configuration for subject S1 the total classification accuracy is improved as 9.4% and 1.7%. And also, subject 7 at BLDA and υ-SVM with LPC model algorithms (LPC+BLDA and LPC+ υ-SVM after block 11th converged to maximum accuracy but Fisher Linear Discriminant Analysis (FLDA algorithm did not converge to maximum accuracy (with the same configuration. So, it can be used as a promising tool in designing BCI systems.

  2. The γ-secretase cleavage product of Polycystin-1 regulates TCF and CHOP-mediated transcriptional activation through a p300-dependent mechanism

    Science.gov (United States)

    Merrick, David; Chapin, Hannah; Baggs, Julie E.; Yu, Zhiheng; Somlo, Stefan; Sun, Zhaoxia; Hogenesch, John B.; Caplan, Michael

    2011-01-01

    Summary Mutations in Pkd1, encoding polycystin-1 (PC1), cause Autosomal Dominant Polycystic Kidney Disease (ADPKD). We show that the carboxy-terminal tail (CTT) of PC1 is released by γ-secretase-mediated cleavage and regulates the Wnt and CHOP pathways by binding the transcription factors TCF and CHOP, disrupting their interaction with the common transcriptional co-activator p300. Loss of PC1 causes increased proliferation and apoptosis, while reintroducing PC1-CTT into cultured Pkd1 null cells reestablishes normal growth rate, suppresses apoptosis, and prevents cyst formation. Inhibition of γ-secretase activity impairs the ability of PC1 to suppress growth and apoptosis, and leads to cyst formation in cultured renal epithelial cells. Expression of the PC1-CTT is sufficient to rescue the dorsal body curvature phenotype in zebrafish embryos resulting from either γ-secretase inhibition or suppression of Pkd1 expression. Thus, γ-secretase-dependent release of the PC1-CTT creates a protein fragment whose expression is sufficient to suppress ADPKD-related phenotypes in vitro and in vivo. PMID:22178500

  3. Light on! Real world evaluation of a P300-based brain-computer interface (BCI) for environment control in a smart home.

    Science.gov (United States)

    Carabalona, Roberta; Grossi, Ferdinando; Tessadri, Adam; Castiglioni, Paolo; Caracciolo, Antonio; de Munari, Ilaria

    2012-01-01

    Brain-computer interface (BCI) systems aim to enable interaction with other people and the environment without muscular activation by the exploitation of changes in brain signals due to the execution of cognitive tasks. In this context, the visual P300 potential appears suited to control smart homes through BCI spellers. The aim of this work is to evaluate whether the widely used character-speller is more sustainable than an icon-based one, designed to operate smart home environment or to communicate moods and needs. Nine subjects with neurodegenerative diseases and no BCI experience used both speller types in a real smart home environment. User experience during BCI tasks was evaluated recording concurrent physiological signals. Usability was assessed for each speller type immediately after use. Classification accuracy was lower for the icon-speller, which was also more attention demanding. However, in subjective evaluations, the effect of a real feedback partially counterbalanced the difficulty in BCI use. Since inclusive BCIs require to consider interface sustainability, we evaluated different ergonomic aspects of the interaction of disabled users with a character-speller (goal: word spelling) and an icon-speller (goal: operating a real smart home). We found the first one as more sustainable in terms of accuracy and cognitive effort.

  4. 综合心理行为干预对军事演习应激状态官兵心理健康和事件相关电位P300的影响%Effects of the comprehensive psychological behavior intervention on mental health and event-related potential P300 of the servicemen under military exercise

    Institute of Scientific and Technical Information of China (English)

    甘景梨; 段惠峰; 祝希泉; 赵兰民; 张东卫; 高存友

    2011-01-01

    目的 探讨综合心理行为干预对军事演习应激状态下官兵心理健康和事件相关电位P300的影响.方法 以某部参加军事演习的127名官兵为研究对象,以班为单位按随机数字表法分为研究组(63例)和对照组(64例),研究组演习前进行6周的心理行为与太极拳训练等综合干预.干预前1 d(干预前)、军事演习后第2天(干预后)分别对2组进行症状自评量表(Symptom Checklist-90,SCL-90)评估和事件相关电位P300检测.结果 (1)心理健康指标比较:与干预前比较,研究组干预后躯体化、人际关系敏感、焦虑因子分均降低,对照组躯体化、人际关系敏感、恐怖因子分及SCL-90总分均升高(P均<0.05);与对照组比较,干预前2组SCL-90总分及各项因子分差异均无统计学意义(P均>0.05),干预后研究组躯体化、人际关系敏感、焦虑、恐怖因子分均低于对照组(P均<0.05).(2)事件相关电位P300指标比较:与干预前比较,研究组干预后Cz与FPz点P300靶刺激P3波幅升高(q=3.45、3.46,P均<0.05),FPz点非靶刺激P2潜伏期(167.8±23.5)ms,短于干预前[(188.3±25.2)ms;q=3.54,P<0.05];对照组干预后FPz点靶刺激P3潜伏期长于干预前(q=3.64,P<0.05);与对照组比较,干预前2组Cz、FPz点潜伏期及波幅的差异均无统计学意义(F检验,P均>0.05);干预后研究组Cz与FPz点靶刺激P3和非靶刺激P2潜伏期均短于对照组(P均<0.05),Cz与FPz点靶刺激P3和FPz点非靶刺激P2波幅均高于对照组(q=3.34、3.35、3.68,P均<0.05).结论 综合心理行为干预能够改善军事演习应激条件下官兵的心理健康水平和部分电生理指标.%Objective To explore the effects of the comprehensive psychological behavior intervention on the mental health and event-related potentials ( ERPs ) of the servicemen under military exercise. Methods One hundred and twenty-seven servicemen who participated in the military exercise were randomly divided into

  5. POTENCIAL PRODUTIVO DE CULTIVARES DE MORANGUEIRO

    Directory of Open Access Journals (Sweden)

    AMANDA GONÇALVES GUIMARÃES

    2015-03-01

    Full Text Available RESUMO O objetivo foi avaliar o potencial produtivo de cultivares de morangueiro em região representativa do Alto Jequitinhonha. O experimento foi conduzido na fazenda Mape Frutas Ltda., localizada no município de Datas-MG, em delineamento em blocos ao acaso, com oito cultivares de morangueiro em quatro repetições, para verificar a produção de mudas e de frutos. A contagem da produção de estolões e de mudas foi realizada aos 180 dias após o plantio. A avaliação das variáveis relacionadas à produção de frutos foi feita duas vezes por semana, no período de maio a outubro de 2012. Das cultivares de dias curtos (Festival, Campinas, Toyonoka, Dover, Oso Grande e Camarosa e dias neutros (Diamante e Aromas, apenas Toyonoka foi a que apresentou menor desempenho para as variáveis. A significativa superioridade das cultivares Camarosa e Festival, para praticamente todas as variáveis avaliadas, permite recomendá-las para regiões com características edafoclimáticas semelhantes às da região onde o experimento foi conduzido. Dentre as cultivares avaliadas, as mais precoces tenderam a apresentar maior desempenho para variáveis relacionadas à produção de frutos.

  6. Financial incentive does not affect P300 (in response to certain episodic and semantic probe stimuli) in the Complex Trial Protocol (CTP) version of the Concealed Information Test (CIT) in detection of malingering.

    Science.gov (United States)

    Rosenfeld, J Peter; Labkovsky, Elena; Davydova, Elena; Ward, Anne; Rosenfeld, Lauren

    2017-05-01

    Previous research indicated that the skin conductance response of the autonomic nervous system in the Concealed Information Test (CIT) is typically increased in subjects who are financially and otherwise incentivized to defeat the CIT (the paradoxical "motivational impairment" effect). This is not the case for RT-based CITs, nor P300 tests based on the three-stimulus protocol for detection of cognitive malingering (although these are not the same as CITs). The present report is the first attempt to study the effect of financial motivation on the P300-based Complex Trial Protocol using both episodic and semantic memory probe and irrelevant stimuli. The Test of Memory Malingering (TOMM) was used to validate behavioral differences between the two groups we created by offering one (paid) group but not another (unpaid) group a financial reward for beating our tests. Group behavioral differences on the TOMM did confirm group manipulations. Probe-minus-irrelevant P300 differences did not differ between groups, although as previously, semantic memory-evoked P300s were larger than episodic memory-evoked P300s. © 2017 Society for Psychophysiological Research.

  7. Los perfiles cognitivos psicopatológicos en la formulación cognitiva de caso

    Directory of Open Access Journals (Sweden)

    Ronald Toro

    2010-01-01

    Full Text Available Se resaltó la relevancia de incluir los perfiles cognitivos desarrollados de acuerdo con las categorías diagnósticas del DSM-IV TR para los trastornos de la personalidad en la formulación cognitiva de caso. Los contenidos informacionales deben dar cuenta del perfil cognitivo específico del paciente, con el fin de facilitar la planeación y el curso del tratamiento ajustado a sus necesidades, aunque no presente diagnóstico en el eje II. También se analizaron las implicaciones del uso inadecuado de las categorías diagnósticas en los trastornos de la personalidad; la necesidad de generar investigación en torno al soporte empírico y psicométrico derivado de la presente propuesta, y el entrenamiento de terapeutas cognitivos en formulación cognitiva de caso.

  8. LOS PERFILES COGNITIVOS PSICOPATOLÓGICOS EN LA FORMULACIÓN COGNITIVA DE CASO

    Directory of Open Access Journals (Sweden)

    Ronald Toro

    2010-01-01

    Full Text Available Se resaltó la relevancia de incluir los perfiles cognitivos desarrolladosde acuerdo con las categorías diagnósticas delDSM-IV TR para los trastornos de la personalidad en la formulacióncognitiva de caso. Los contenidos informacionalesdeben dar cuenta del perfil cognitivo específico del paciente,con el fin de facilitar la planeación y el curso del tratamientoajustado a sus necesidades, aunque no presente diagnósticoen el eje II. También se analizaron las implicaciones del usoinadecuado de las categorías diagnósticas en los trastornos dela personalidad; la necesidad de generar investigación en tornoal soporte empírico y psicométrico derivado de la presentepropuesta, y el entrenamiento de terapeutas cognitivos en formulacióncognitiva de caso.

  9. miR-17-5p targets the p300/CBP-associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells

    International Nuclear Information System (INIS)

    Gong, Ai-Yu; Eischeid, Alex N; Xiao, Jing; Zhao, Jian; Chen, Dongqing; Wang, Zhao-Yi; Young, Charles YF; Chen, Xian-Ming

    2012-01-01

    Androgen receptor (AR) signalling is critical to the initiation and progression of prostate cancer (PCa). Transcriptional activity of AR involves chromatin recruitment of co-activators, including the p300/CBP-associated factor (PCAF). Distinct miRNA expression profiles have been identified in PCa cells during the development and progression of the disease. Whether miRNAs regulate PCAF expression in PCa cells to regulate AR transcriptional activity is still unclear. Expression of PCAF was investigated in several PCa cell lines by qRT-PCR, Western blot, and immunocytochemistry. The effects of PCAF expression on AR-regulated transcriptional activity and cell growth in PCa cells were determined by chromatin immunoprecipitation, reporter gene construct analysis, and MTS assay. Targeting of PCAF by miR-17-5p was evaluated using the luciferase reporter assay. PCAF was upregulated in several PCa cell lines. Upregulation of PCAF promoted AR transcriptional activation and cell growth in cultured PCa cells. Expression of PCAF in PCa cells was associated with the downregulation of miR-17-5p. Targeting of the 3’-untranslated region of PCAF mRNA by miR-17-5p caused translational suppression and RNA degradation, and, consequently, modulation of AR transcriptional activity in PCa cells. PCAF is upregulated in cultured PCa cells, and upregulation of PCAF is associated with the downregulation of miR-17-5p. Targeting of PCAF by miR-17-5p modulates AR transcriptional activity and cell growth in cultured PCa cells

  10. Perfil cognitivo de la dependencia emocional en estudiantes universitarios en Medellín, Colombia

    OpenAIRE

    Lemos Hoyos, Mariantonia; Jaller Jaramillo, Cristina; González Calle, Ana María; Díaz León, Zoraya Tatiana; De la Ossa, Daniela

    2012-01-01

    El objetivo de este estudio fue la identificación del perfil cognitivo de los estudiantes universitarios con dependencia emocional. Ésta se plantea como un patrón orientado al otro como fuente de satisfacción y seguridad personal, donde el perfil cognitivo les llevaría a interpretar los hechos de manera diferente, basándose en cubrir sus necesidades emocionales insatisfechas. Se tomó una muestra aleatoria estratificada de 569 estudiantes universitarios. Los resultados arrojaron un modelo que ...

  11. Autorregulación del estilo cognitivo a través del lenguaje

    OpenAIRE

    Loscos Lucero, María Paz

    2001-01-01

    El estilo cognitivo de un individuo se puede definir como el modo en que aborda sus tareas perceptuales y cognitivas. Entre todos los estilos cognitivos propuestos por los autores interesados en el tema, como "formas o modos" de percibir, conocer, resolver problemas o recordar, se ha seleccionado para su desarrollo en el presente trabajo el de la "Dependencia-Independencia de Campo (D.I.C.)". Esta dimensión cognoscitiva supone una tendencia a analizar el entorno o campo perceptual en partes c...

  12. A P300-based Brain-Computer Interface with Stimuli on Moving Objects: Four-Session Single-Trial and Triple-Trial Tests with a Game-Like Task Design

    Science.gov (United States)

    Ganin, Ilya P.; Shishkin, Sergei L.; Kaplan, Alexander Y.

    2013-01-01

    Brain-computer interfaces (BCIs) are tools for controlling computers and other devices without using muscular activity, employing user-controlled variations in signals recorded from the user’s brain. One of the most efficient noninvasive BCIs is based on the P300 wave of the brain’s response to stimuli and is therefore referred to as the P300 BCI. Many modifications of this BCI have been proposed to further improve the BCI’s characteristics or to better adapt the BCI to various applications. However, in the original P300 BCI and in all of its modifications, the spatial positions of stimuli were fixed relative to each other, which can impose constraints on designing applications controlled by this BCI. We designed and tested a P300 BCI with stimuli presented on objects that were freely moving on a screen at a speed of 5.4°/s. Healthy participants practiced a game-like task with this BCI in either single-trial or triple-trial mode within four sessions. At each step, the participants were required to select one of nine moving objects. The mean online accuracy of BCI-based selection was 81% in the triple-trial mode and 65% in the single-trial mode. A relatively high P300 amplitude was observed in response to targets in most participants. Self-rated interest in the task was high and stable over the four sessions (the medians in the 1st/4th sessions were 79/84% and 76/71% in the groups practicing in the single-trial and triple-trial modes, respectively). We conclude that the movement of stimulus positions relative to each other may not prevent the efficient use of the P300 BCI by people controlling their gaze, e.g., in robotic devices and in video games. PMID:24302977

  13. Topografia y reactividad del potencial evocado visual

    Directory of Open Access Journals (Sweden)

    R. Etcheberrigaray

    1988-09-01

    Full Text Available El aumento - reducción (A-R visual es evidente para las áreas centrales y exhibe diferencias hemisféricas. Este trabajo describe las características del potencial evocado visual (PEV en derivaciones occipitales y su relación con A-R central: 16 sujetos de sexo masculino, diestros, jóvenes y sanos recibieron flashes de 10 us, frec de 1/s a intensidades de 0.36, 0.72 y 1.44 joules mediante estimulador Grass PS2. Se registró derivaciones Cz, C3, C4, Oz, O1 y 02 referidas a mastoides mediante electrodos subdérmicos. Un computador Nicolet CA-1000 promedió 100 respuestas para cada intensidad. Se midió latencia y amplitud peak to peak de los complejos P1N1 y N1P2 y se calculó pendiente intensidad/amplitud mediante regresión lineal. 10 sujetos tuvieron pendiente mayor que 0 en vertex (aumentadores y 6 menor (reductores. P1N1 presenta reducción y asimetría hemisférica en Cz, que no se observa en Oz. Los aumentadores de N1P2 a nivel de Cz son reductores a nivel de, Oz y viceversa. Se discuten estos hallazgos en relación a las etapas en el procesamiento de la información visual y la significación funcional de los componentes del PEV.

  14. The Role of the Interplay between Stimulus Type and Timing in Explaining BCI-Illiteracy for Visual P300-Based Brain-Computer Interfaces

    Directory of Open Access Journals (Sweden)

    Roberta Carabalona

    2017-06-01

    Full Text Available Visual P300-based Brain-Computer Interface (BCI spellers enable communication or interaction with the environment by flashing elements in a matrix and exploiting consequent changes in end-user's brain activity. Despite research efforts, performance variability and BCI-illiteracy still are critical issues for real world applications. Moreover, there is a quite unaddressed kind of BCI-illiteracy, which becomes apparent when the same end-user operates BCI-spellers intended for different applications: our aim is to understand why some well performers can become BCI-illiterate depending on speller type. We manipulated stimulus type (factor STIM: either characters or icons, color (factor COLOR: white, green and timing (factor SPEED: fast, slow. Each BCI session consisted of training (without feedback and performance phase (with feedback, both in copy-spelling. For fast flashing spellers, we observed a performance worsening for white icon-speller. Our findings are consistent with existing results reported on end-users using identical white×fast spellers, indicating independence of worsening trend from users' group. The use of slow stimulation timing shed a new light on the perceptual and cognitive phenomena related to the use of a BCI-speller during both the training and the performance phase. We found a significant STIM main effect for the N1 component on Pz and PO7 during the training phase and on PO8 during the performance phase, whereas in both phases neither the STIM×COLOR interaction nor the COLOR main effect was statistically significant. After collapsing data for factor COLOR, it emerged a statistically significant modulation of N1 amplitude depending to the phase of BCI session: N1 was more negative for icons than for characters both on Pz and PO7 (training, whereas the opposite modulation was observed for PO8 (performance. Results indicate that both feedback and expertise with respect to the stimulus type can modulate the N1 component and

  15. El lenguaje no verbal: un proceso cognitivo superior indispensable para el ser humano

    OpenAIRE

    Corrales Navarro, Elizabeth

    2013-01-01

    El lenguaje no verbal ha sido vital para la conservación y evolución de nuestra especie. El presente artículo recopila datos sobre la importancia evolutiva del lenguaje no verbal para el homo sapiens sapiens, y explica que sin este importante proceso cognitivo, no hubiera sido posible el paso hacia el lenguaje verbal.

  16. Mild cognitive impairment: cognitive screening or neuropsychological assessment? Comprometimento cognitivo leve: rastreio cognitivo ou avaliação neuropsicológica?

    Directory of Open Access Journals (Sweden)

    Breno Satler Diniz

    2008-12-01

    Full Text Available OBJECTIVE: To describe the neuropsychological profile of mild cognitive impairment subtypes (amnestic, non-amnestic and multiple-domain of a clinical sample. We further address the diagnostic properties of the Mini-Mental State Examination and the Cambridge Cognitive Examination for the identification of the different mild cognitive impairment subtypes in clinical practice. METHOD: Cross-sectional clinical and neuropsychological evaluation of 249 elderly patients attending a memory clinic at a university hospital in Sao Paulo, Brazil. RESULTS: The performance of patients with mild cognitive impairment was heterogeneous across the different subtests of the neuropsychological battery, with a trend towards an overall worse performance for amnestic (particularly multiple domain mild cognitive impairment as compared to non-amnestic subtypes. Screening tests for dementia (Mini-Mental State Examination and Cambridge Cognitive Examination adequately discriminated cases of mild Alzheimer's disease from controls, but they were not accurate to discriminate patients with mild cognitive impairment (all subtypes from control subjects. CONCLUSIONS: The discrimination of mild cognitive impairment subtypes was possible only with the aid of a comprehensive neuropsychological assessment. It is necessary to develop new strategies for mild cognitive impairment screening in clinical practice.OBJETIVO: Descrever o perfil neuropsicológico dos subtipos de comprometimento cognitivo leve, amnéstico, não-amnéstico e múltiplos domínios, de uma amostra clínica. Além disto, avaliou-se as propriedades diagnósticas do Mini-exame do Estado Mental e do Cambridge Cognitive Examination na identificação dos diferentes subtipos de comprometimento cognitivo leve na prática clínica. MÉTODO: Avaliação clínica e neuropsicológica transversal de 249 idosos em uma clínica de memória de um hospital universitário em São Paulo, Brasil. RESULTADOS: Testes de rastreio para

  17. Medición del potencial humano en las organizaciones

    OpenAIRE

    Fuchs Ángeles, Rosa María

    2015-01-01

    Las empresas alrededor del mundo se encuentran preocupadas por la gestión del talento en sus organizaciones.Parte de la preocupación consiste en retener a los colaboradores talentosos y esto no puede ser posible, siestos no se identifican adecuadamente. Las evaluaciones de desempeño y potencial cobran, entonces,importancia. Las evaluaciones de desempeño califican el récord histórico del colaborador, por lo que sumedición se facilita. Sin embargo, la medición del potencial evalúa su posible de...

  18. El mapa cognitivo en los procesos de evaluación del aprendizaje

    OpenAIRE

    William R. Avendaño C.; Abad E. Parada-Trujillo

    2012-01-01

    En este artículo se hace una revisión del mapa cognitivo de Reuven Feuerstein como instrumento de evaluación. El objetivo de este artículo, por lo tanto, es el análisis del mapa cognitivo en el marco de la evaluación, las ciencias cognitivas y su pertinencia como herramienta de uso en el aula de clase. Metodología: para el logro de ese objetivo se hizo una amplia revisión de la literatura en torno de la evaluación, la práctica de la calificación, los aportes de las ciencias cognitivas y los a...

  19. Nivel cognitivo de las preguntas que formulan las educadoras de párvulos

    Directory of Open Access Journals (Sweden)

    Bernardita Tornero

    2015-05-01

    Full Text Available El objetivo principal de este estudio es identificar y clasificar en categorías y subcategorías el nivel cognitivo de las preguntas formuladas por las educadoras de párvulos durante la "hora del cuento". Para ello se confeccionó una pauta basándose en la taxonomía de Bloom adaptada por Anderson, y se observó a 63 educadoras de párvulos de segundo nivel de transición provenientes de 37 escuelas particulares subvencionadas de 7 comunas de la región metropolitana de Santiago de Chile. Los resultados señalan que, en promedio, las educadoras formulan 33 preguntas durante "la hora del cuento", pero que a pesar de que la mayoría son preguntas abiertas, demandan bajos niveles cognitivos.

  20. Procesos cognitivos distorsionados en la conducta agresiva y antisocial en adolescentes

    Directory of Open Access Journals (Sweden)

    David Roncero

    2016-01-01

    Full Text Available En el presente trabajo se realiza una revisión de diferentes aportaciones teóricas y empíricas que abordan la relación entre las conductas agresivas y antisociales en la adolescencia y un conjunto de procesos cognitivos distorsionados que interfieren en la percepción y comprensión de los eventos o experiencias sociales. A partir de las diferentes aproximaciones teóricas, en esta revisión se sugiere la necesidad de contar con una perspectiva más integradora que permita una mejor conceptualización y tipificación de estos procesos cognitivos distorsionados, a fin de clarificar la naturaleza y la función específica que cada uno de ellos desempeña en la explicación del comportamiento agresivo y antisocial en adolescentes.

  1. Terapia cognitivo-comportamental da depressão Cognitive-behavioral therapy for depression

    Directory of Open Access Journals (Sweden)

    Vania Bitencourt Powell

    2008-10-01

    Full Text Available OBJETIVO: Descrever o uso de técnicas cognitivas e revisar os estudos de eficácia da terapia cognitivo-comportamental no tratamento da depressão. MÉTODO: Revisão não-sistemática proveniente dos estudos originais, complementada por informações provenientes de metanálises e livros-texto especializados. RESULTADOS: Foram descritos os fundamentos da terapia cognitivo-comportamental no tratamento da depressão e revisadas as evidências de eficácia em curto e longo prazo. Discutimos igualmente o uso de tratamento farmacológico concomitante à terapia cognitivo-comportamental. CONCLUSÕES: A terapia cognitivo-comportamental é uma das abordagens que apresentam mais evidências empíricas de eficácia no tratamento da depressão, quer oferecida de forma isolada ou em combinação com farmacoterapia.OBJECTIVE: To describe the use of cognitive techniques and to review studies on the efficacy of CBT in the treatment of depression. METHOD: A non-systematic review of the literature of original studies complemented with data from meta-analyses and specialized textbooks. RESULTS: The fundamentals of cognitive-behavioral therapy in the treatment of depression are described and the evidence of short- and long-term efficacy is reviewed. The use of pharmacological therapy in conjunction with CBT is also discussed. CONCLUSIONS: CBT in the treatment of depression is one of the therapeutic modalities with the highest empirical evidence of efficacy, whether applied alone or in combination with pharmacotherapy.

  2. La competencia intercultural en un lugar de trabajo internacional. Un enfoque cognitivo-pragmático

    DEFF Research Database (Denmark)

    Dam, Lotte; García Agustín, Óscar

    2012-01-01

    Los empleados en empresas multinacionales no solo aplican sus competencias laborales para desempeñar su trabajo, sino que recurren a sus competencias interculturales. En este artículo, analizamos la competencia intercultural desde un enfoque cognitivo-pragmático para dar cuenta del modo en que em...... términos culturales, combinando representaciones estereotipadas con nuevas categorías fruto del aprendizaje intercultural....

  3. Relevancia e Inferencia: Procesos cognitivos propios de la comunicación humana

    Directory of Open Access Journals (Sweden)

    Moya Pardo Constanza

    2006-06-01

    Full Text Available Este artículo pretende mostrar los planteamientos cognitivos más representativos de la Teoría de la Relevancia propuesta por Spelber & Wilson con respecto al modelo ostensivoinferencial. Este modelo plantea un mecanismo deductivo explícito que da cuenta de los procesos y estrategias que permiten el paso del significado literal a la interpretación pragmática de los mensajes en el proceso de comunicación humana.

  4. Sondeo compresivo aplicado al sondeo de espectro de banda ancha eficiente en sistemas de radio cognitivo

    Directory of Open Access Journals (Sweden)

    Evelio Astaiza Hoyos

    2017-01-01

    Full Text Available Contexto: El sondeo de espectro es universalmente conocido como el principal habilitador de radio cognitivo (CR, dado que dota al dispositivo de CR de la capacidad de conocimiento del entorno de radio. Objetivo: En este artículo se presenta un algoritmo diseñado para realizar el sondeo de espectro de banda ancha en sistemas de radio cognitivo (CR. Método: El sondeo de espectro está basado en sondeo compresivo (CS, mediante el cual los usuarios cognitivos, sin necesidad de conocimiento a priori de características de la señal en el entorno de radio, minimizan la cantidad de muestras a procesar y, con ello, reducen de forma proporcional los tiempos de detección, consumos de energía y capacidades de procesamiento requeridas en los dispositivos de radio cognitivo (CRD. Resultados:  El desempeño del algoritmo propuesto se evalúa mediante la obtención de las curvas de probabilidad de detección, probabilidad de omisión de detección, probabilidad de falsa alarma y las características operativas del receptor (ROC en comparación con otros algoritmos propuestos en el estado del arte. Conclusión: Los resultados de simulación demuestran que el método propuesto permite realizar el sondeo de espectro de manera eficiente, mejorando el desempeño del sondeo en función de la probabilidad de detección y de las características operacionales del receptor con respecto a otros algoritmos propuestos basados en muestreo sub-Nyquist.

  5. Riesgo de deterioro cognitivo en personas mayores de las subregiones de Antioquia, Colombia

    Directory of Open Access Journals (Sweden)

    Angela Segura Cardona

    Full Text Available Resumen En este artículo, se buscó conocer la prevalencia de riesgo de deterioro cognitivo y su relación con factores demográficos, sociales y funcionales en las personas mayores de las subregiones de Antioquia, Colombia. Se trata de un estudio cuantitativo, transversal analítico, con fuente de información primaria. La muestra fue probabilística y se determinó el riesgo de deterioro cognitivo con la escala minimental. Así se encontró que el 83,1% de los mayores presenta algún riesgo de deterioro cognitivo, principalmente las mujeres, y está asociado significativamente con vivir en la subregión del Magdalena Medio y Medellín, tener mayor edad, no tener pareja, no tener escolaridad, tener escasos recursos sociales, no participar en grupos comunitarios, tener mala percepción de la calidad de vida, estar insatisfecho con la salud y tener dependencia funcional para realizar las actividades básicas. Estos resultados permiten orientar los programas de salud pública relacionados con la inclusión de las personas mayores hacia programas educativos, la participación en grupos comunitarios, la tamización constante en los servicios de salud, el fortalecimiento de los recursos sociales y el fomento de la actividad física en la vejez, para lograr un envejecimiento saludable con mejor calidad de vida.

  6. Cierre cognitivo, sexismo y religiosidad: diferencias y similitudes entre grupos de adolescentes con distinta cultura

    Directory of Open Access Journals (Sweden)

    Manuel Moyano

    2013-05-01

    Full Text Available Desde el ámbito de la cognición social motivada, la necesidad de cierre cognitivo emerge como una variable crucial para la mejor comprensión de las diferencias individuales en variables psicosociales asociadas a la cultura y, además, susceptible de tener en cuenta en programas de intervención cuyo objetivo vaya dirigido a modificar actitudes ancladas en el prejuicio y la discriminación. En la presente investigación se ha realizado un estudio de este constructo motivacional y su relación con el sexismo y la religiosidad en una muestra de adolescentes cristianos y musulmanes, todos ellos residentes en un contexto social con un marcado carácter multicultural. De acuerdo con los datos obtenidos, no se han encontrado diferencias entre musulmanes y cristianos en necesidad de cierre cognitivo y sexismo. Sin embargo, se han encontrado diferencias por sexo en sexismo hostil. La necesidad de cierre cognitivo correlacionó de una forma estadísticamente significativa con el sexismo (hostil y benevolente, y es un buen predictor. Los musulmanes puntuaron de una forma significativamente más elevada que los cristianos en los indicadores de religiosidad. Se discuten los resultados en el marco de investigaciones previas.

  7. Relaciones entre logro de aprendizaje, automonitoreo, estilo cognitivo y estilos de aprendizaje en estudiantes de medicina

    Directory of Open Access Journals (Sweden)

    Jorge Martínez-Bernal

    2016-07-01

    Full Text Available Se presenta un análisis de las relaciones que existen entre logro de aprendizaje, uso de automonitoreo metacognitivo, estilo cognitivo (dimensión Dependencia- Independencia de Campo y estilo de aprendizaje (Clasificación de Grasha, en estudiantes universitarios. El estudio se realizó con una población de 130 alumnos de una facultad de medicina de 6º a 10º semestre en una universidad en Bogotá, Colombia. Utilizando la metodología de correlaciones bivariadas se buscaron asociaciones entre el promedio académico alcanzado por los estudiantes, el automonitoreo metacognitivo, medido con el cuestionario MSQL, los estilos cognitivos por medio de la prueba EFT y los estilos de aprendizaje reportados en el inventario de Grasha. Los resultados mostraron correlaciones positivas del logro de aprendizaje con las variables: estilo cognitivo, uso de estrategias metacognitivas, estilos de aprendizaje competitivo y participativo, y correlaciones negativas con los estilos de aprendizaje evasivo y dependiente. De igual forma se encontraron otras correlaciones entre las variables de estudio que son discutidas en el documento.

  8. Fatores prognósticos para o desenvolvimento cognitivo de prematuros de muito baixo peso

    Directory of Open Access Journals (Sweden)

    Maria Dalva Barbosa Baker Méio

    2003-06-01

    Full Text Available OBJETIVO: Crianças prematuras, de muito baixo peso, podem apresentar alterações em seu desenvolvimento cognitivo. No Brasil, pouco se conhece sobre a evolução dessas crianças na idade pré-escolar. O objetivo do estudo foi descrever o desenvolvimento cognitivo de uma população de recém-nascidos prematuros de muito baixo peso e verificar possíveis fatores prognósticos para desenvolvimento cognitivo anormal. MÉTODOS: Um estudo de coorte foi realizado com uma população de crianças pré-escolares, nascidas prematuras, de muito baixo peso, entre janeiro de 1991 e setembro de 1993. O desenvolvimento cognitivo foi avaliado por meio do teste WPPSI-R (Wechsler Preschool and Primary Intelligence Scales aplicado por psicólogas, utilizando dois pontos de corte para definição de anormalidade: escores abaixo de 1 e 2, desvios padrões da média (DP. RESULTADOS: Foram avaliadas 79 crianças de quatro a cinco anos de idade. A média do escore total do teste WIPPSI-R foi de 75,6 (±11,9. A incidência de escore total anormal foi de 77,2% e de 32,9% (1DP e 2 DP, respectivamente. Após o ajuste por "tipo de parto", ser pequeno para a idade gestacional (OR=6,19; IC95% 1,60-23,86, ultra-som transfontanela anormal (OR=5,90; IC95% 1,04-9,83 e ser do sexo masculino (OR=3,20; IC 95% 1,32-26,35 foram os fatores que predisseram escore total <70 (2 DP. CONCLUSÃO: Houve maior comprometimento do desenvolvimento cognitivo nas crianças estudadas do que o descrito na literatura. Ser pequeno para idade gestacional, ultra-som transfontanela anormal e sexo masculino foram fatores prognósticos de pior evolução.

  9. Método del aprendizaje cognitivo con metacognición en electrostática

    Directory of Open Access Journals (Sweden)

    Carlos Briones Galarza

    2016-06-01

    Full Text Available El  propósito  de  este  trabajo  fue  determinar  la  ventaja  que  tiene  la  aplicación  del Aprendizaje  Cognitivo  en  la  resolución  de  problemas  y  la  utilización de la Metacognición  en  la  enseñanza  de  la  Electrostática.  El Aprendizaje  Cognitivo con Metacognición se aplicó en una muestra de 18 estudiantes de una población de 119 estudiantes secundarios de los Terceros de Barchillerato de la Especialización de Físico-Matemáticas registrados en tres colegios de la ciudad de Guayaquil en la asignatura de Física. Se hizo una división de cuatro grupos, los estudiantes de dos grupos recibieron Aprendizaje Cognitivo, uno con Metacognición y otro sin Metacognición; y los otros dos grupos no recibieron Aprendizaje Cognitivo pero en un curso se dio Metacognición y en otro no. A todos los grupos se les aplicó una prueba de entrada y una de salida de Electrostática (Ley de Coulomb y Campo Eléctrico, luego se determinó con la prueba de salida la ganancia que tuvieron los grupos que recibieron el tratamiento. Se tomó una prueba de lectura, Prueba C10ze, donde se determinó el nivel de comprensión lectora de los grupos de estudiantes y una prueba de estilos de aprendizaje de las personas, Cuestionario de Felder y Silverman. Este estudio probó la hipótesis que los estudiantes que recibieron clases con el Aprendizaje Cognitivo con Metacognición para el tema de la Electrostática, tanto en la solución de problemas como en la parte conceptual; tienen un mejor rendimiento académico que aquellos estudiantes que no recibieron dicho aprendizaje.

  10. Medición del potencial humano en las organizaciones

    Directory of Open Access Journals (Sweden)

    Rosa María Fuchs Ángeles

    2010-11-01

    Full Text Available Las empresas alrededor del mundo se encuentran preocupadas por la gestión del talento en sus organizaciones.Parte de la preocupación consiste en retener a los colaboradores talentosos y esto no puede ser posible, siestos no se identifican adecuadamente. Las evaluaciones de desempeño y potencial cobran, entonces,importancia. Las evaluaciones de desempeño califican el récord histórico del colaborador, por lo que sumedición se facilita. Sin embargo, la medición del potencial evalúa su posible desempeño en cargos futuros,razón por la cual no es una tarea sencilla. Por ello, en este artículo se presentarán las características que seevalúan en los colaboradores con potencial y las herramientas que se suelen utilizar. Se presenta, además,la realidad sobre este tema de cuatro empresas que operan en el Perú.

  11. Gallic acid-capped gold nanoparticles inhibit EGF-induced MMP-9 expression through suppression of p300 stabilization and NFκB/c-Jun activation in breast cancer MDA-MB-231 cells

    International Nuclear Information System (INIS)

    Chen, Ying-Jung; Lee, Yuan-Chin; Huang, Chia-Hui; Chang, Long-Sen

    2016-01-01

    Triple-negative breast cancers (TNBCs) are highly invasive and have a higher rate of distant metastasis. Matrix metalloproteinase-9 (MMP-9) plays a crucial role in EGF/EGFR-mediated malignant progression and metastasis of TNBCs. Various studies have revealed that treatment with gallic acid down-regulates MMP-9 expression in cancer cells, and that conjugation of phytochemical compounds with gold nanoparticles (AuNPs) increases the anti-tumor activity of the phytochemical compounds. Thus, the effect of gallic acid-capped AuNPs (GA-AuNPs) on MMP-9 expression in EGF-treated TNBC MDA-MB-231 cells was analyzed in the present study. The so-called green synthesis of AuNPs by means of gallic acid was performed at pH 10, and the resulting GA-AuNPs had spherical shape with an average diameter of approximately 50 nm. GA-AuNPs notably suppressed migration and invasion of EGF-treated cells, and inhibited EGF-induced MMP-9 up-regulation. GA-AuNPs abrogated EGF-induced Akt/p65 and ERK/c-Jun phosphorylation, leading to down-regulation of MMP-9 mRNA and protein expression in EGF-treated cells. Meanwhile, EGF-induced p300 stabilization was found to be involved in MMP-9 expression, whereas GA-AuNPs inhibited the EGF-promoted stability of the p300 protein. Although GA-AuNPs and gallic acid suppressed EGF-induced MMP-9 up-regulation via the same signaling pathway, the effective concentration of gallic acid was approximately 100-fold higher than that of GA-AuNPs for inhibition of MMP-9 expression in EGF-treated cells to a similar extent. Collectively, our data indicate that, in comparison with gallic acid, GA-AuNPs have a superior ability to inhibit EGF/EGFR-mediated MMP-9 expression in TNBC MDA-MB-231 cells. Our findings also point to a way to improve the anti-tumor activity of gallic acid. - Highlights: • Gallic acid-capped gold nanoparticles inhibit EGF-induced MMP-9 expression. • EGF-induced MMP-9 expression via p300 stabilization and NFκB/c-Jun activation. • Gallic acid

  12. The activation of p38 MAPK primarily contributes to UV-induced RhoB expression by recruiting the c-Jun and p300 to the distal CCAAT box of the RhoB promoter

    International Nuclear Information System (INIS)

    Ahn, Jiwon; Choi, Jeong-Hae; Won, Misun; Kang, Chang-Mo; Gyun, Mi-Rang; Park, Hee-Moon; Kim, Chun-Ho; Chung, Kyung-Sook

    2011-01-01

    Highlights: → Regulation of transcriptional activation of RhoB is still unclear. → We examine the effect of p38 MAPK inhibition, and c-Jun and RhoB depletion on UV-induced RhoB expression and apoptosis. → We identify the regions of RhoB promoter necessary to confer UV responsiveness using pRhoB-luciferase reporter assays. → c-Jun, ATF2 and p300 are dominantly associated with NF-Y on the distal CCAAT box. → The activation of p38 MAPK primarily contribute to UV-induced RhoB expression by recruiting the c-Jun and p300 proteins on distal CCAAT box of RhoB promoter. -- Abstract: The Ras-related small GTP-binding protein RhoB is rapidly induced in response to genotoxic stresses caused by ionizing radiation. It is known that UV-induced RhoB expression results from the binding of activating transcription factor 2 (ATF2) via NF-Y to the inverted CCAAT box (-23) of the RhoB promoter. Here, we show that the association of c-Jun with the distal CCAAT box (-72) is primarily involved in UV-induced RhoB expression and p38 MAPK regulated RhoB induction through the distal CCAAT box. UV-induced RhoB expression and apoptosis were markedly attenuated by pretreatment with the p38 MAPK inhibitor. siRNA knockdown of RhoB, ATF2 and c-Jun resulted in decreased RhoB expression and eventually restored the growth of UV-irradiated Jurkat cells. In the reporter assay using luciferase under the RhoB promoter, inhibition of RhoB promoter activity by the p38 inhibitor and knockdown of c-Jun using siRNA occurred through the distal CCAAT box. Immunoprecipitation and DNA affinity protein binding assays revealed the association of c-Jun and p300 via NF-YA and the dissociation of histone deacetylase 1 (HDAC1) via c-Jun recruitment to the CCAAT boxes of the RhoB promoter. These results suggest that the activation of p38 MAPK primarily contributes to UV-induced RhoB expression by recruiting the c-Jun and p300 proteins to the distal CCAAT box of the RhoB promoter in Jurkat cells.

  13. Gallic acid-capped gold nanoparticles inhibit EGF-induced MMP-9 expression through suppression of p300 stabilization and NFκB/c-Jun activation in breast cancer MDA-MB-231 cells

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Ying-Jung; Lee, Yuan-Chin; Huang, Chia-Hui [Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan (China); Chang, Long-Sen, E-mail: lschang@mail.nsysu.edu.tw [Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan (China); Department of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan (China)

    2016-11-01

    Triple-negative breast cancers (TNBCs) are highly invasive and have a higher rate of distant metastasis. Matrix metalloproteinase-9 (MMP-9) plays a crucial role in EGF/EGFR-mediated malignant progression and metastasis of TNBCs. Various studies have revealed that treatment with gallic acid down-regulates MMP-9 expression in cancer cells, and that conjugation of phytochemical compounds with gold nanoparticles (AuNPs) increases the anti-tumor activity of the phytochemical compounds. Thus, the effect of gallic acid-capped AuNPs (GA-AuNPs) on MMP-9 expression in EGF-treated TNBC MDA-MB-231 cells was analyzed in the present study. The so-called green synthesis of AuNPs by means of gallic acid was performed at pH 10, and the resulting GA-AuNPs had spherical shape with an average diameter of approximately 50 nm. GA-AuNPs notably suppressed migration and invasion of EGF-treated cells, and inhibited EGF-induced MMP-9 up-regulation. GA-AuNPs abrogated EGF-induced Akt/p65 and ERK/c-Jun phosphorylation, leading to down-regulation of MMP-9 mRNA and protein expression in EGF-treated cells. Meanwhile, EGF-induced p300 stabilization was found to be involved in MMP-9 expression, whereas GA-AuNPs inhibited the EGF-promoted stability of the p300 protein. Although GA-AuNPs and gallic acid suppressed EGF-induced MMP-9 up-regulation via the same signaling pathway, the effective concentration of gallic acid was approximately 100-fold higher than that of GA-AuNPs for inhibition of MMP-9 expression in EGF-treated cells to a similar extent. Collectively, our data indicate that, in comparison with gallic acid, GA-AuNPs have a superior ability to inhibit EGF/EGFR-mediated MMP-9 expression in TNBC MDA-MB-231 cells. Our findings also point to a way to improve the anti-tumor activity of gallic acid. - Highlights: • Gallic acid-capped gold nanoparticles inhibit EGF-induced MMP-9 expression. • EGF-induced MMP-9 expression via p300 stabilization and NFκB/c-Jun activation. • Gallic acid

  14. Efectos de la actividad física sobre el funcionamiento cognitivo en preadolescentes

    Directory of Open Access Journals (Sweden)

    Victoria Gallego Zumaquero

    2015-09-01

    Full Text Available El objetivo de este trabajo fue analizar el efecto de la actividad física en el funcionamiento cognitivo de una muestra preadolescente. Participaron 62 preadolescentes (niños, n = 32; niñas, n = 30 de la ciudad de Málaga (España, con edades comprendidas entre 10 y 12 años (M = 10,48; DT = ,54. Se empleó un diseño cuasi-experimental con un grupo control y otro experimental. Para evaluar el funcionamiento cognitivo se empleó el Test de Claves y el de Búsqueda de Símbolos de la Escala de Inteligencia de Wechsler para Niños (WISC-IV, así como las pruebas Interferencia, Senderos grises y Senderos de color de la batería Evaluación Neuropsicológica de Funciones Ejecutivas en Niños (ENFEN. Asimismo, como variables de control se analizó el tiempo dedicado al estudio y al descanso, así como la condición física a través de la composición corporal, el consumo de oxígeno máximo y el test de salto horizontal. Los resultados obtenidos indican efectos significativos de la práctica física regular sobre algunas medidas de funcionamiento cognitivo evaluadas, aunque los datos deben ser interpretados con cautela por la ausencia de significación en otras medidas analizadas.

  15. El estilo cognitivo y la fijación de metas de aprendizaje en ambientes computacionales

    Directory of Open Access Journals (Sweden)

    Omar López Vargas

    2014-01-01

    Full Text Available Explorar la influencia que ejerce el estilo cognitivo en la dimensión dependencia - independencia de campo sobre la fijación, ajuste y precisión de metas de aprendizaje. De igual manera, explorar dicha influencia en el logro de aprendizaje esperado en estudiantes de secundaria, durante su interacción en la resolución de problemas de triángulos rectángulos a través de un ambiente hipermedial denominado “Softri”. Método. En la investigación participaron 85 estudiantes del grado décimo de un colegio oficial de Bogotá. Se utilizó el EFT para medir el estilo cognitivo. El logro académico se obtuvo a través de evaluaciones realizadas en el escenario computacional. De igual forma, las metas seleccionadas por los sujetos eran registradas por el software ”Softri”. Para el tratamiento de los datos se realizó un análisis Anova, el cual permite establecer la existencia de diferencias significativas en cuanto a las medias del logro de aprendizaje y la formulación de metas entre los diferentes grupos de estudiantes de acuerdo con su estilo cognitivo. Resultados. Se mostró que los estudiantes independientes de campo se fijan metas más altas, siendo más precisos con respecto al logro de aprendizajes esperados. Conclusión. Es posible establecer que los estudiantes independientes de campo poseen altas creencias de control sobre su propio proceso de aprendizaje. Probablemente, poseen un locus de control interno alto. También es viable pensar que estos sujetos, poseen altos niveles de autoeficacia académica atendiendo a que se formulan metas más exigentes. Estas conductas pueden estar asociadas a una mayor capacidad de autorregulación del aprendizaje.

  16. A ficção científica e o estranhamento cognitivo no ensino de ciências: estudos críticos e propostas de sala de aula

    Directory of Open Access Journals (Sweden)

    Luís Paulo Piassi

    2013-01-01

    Full Text Available Este trabalho, partindo da apresentação de propostas de ensino de ciências com o uso da ficção científica e fundamentando-se em referenciais dos estudos literários críticos sobre o gênero, objetiva argumentar que sua maior contribuição para a educação científica não se situa nem na precisão científica, nem na qualidade didática e nem mesmo no potencial lúdico que esse tipo de narrativa desperta. Sem desconsiderar a importância desses aspectos, mostramos que o sentido de levar a ficção científica para as aulas de ciências está nos mecanismos de produção ficcional que, por características que lhe são próprias, envolve um modo especial de raciocinar sobre o mundo natural. Tais mecanismos baseiam-se em conjecturas que promovem o chamado estranhamento cognitivo capaz de promover, nos estudantes, a problematização que pode ser o ponto de partida para uma abordagem crítica, não apenas de conceitos e leis, mas, também, de suas implicações e motivações epistemológicas e socioculturais.

  17. Entrenamiento cognitivo en el primer ciclo de la educación primaria

    OpenAIRE

    Gutiérrez González, Pedro J

    2003-01-01

    Uno de los objetivos primarios de la educación es Enseñar a Pensar a nuestros alumnos desde edades tempranas. Así lo avalan, autores como: de Bono, Feuerstein, Sternberg, Pinillos, etc. La primera parte de nuestra investigación consistió en la confección del Programa FLASH: refuerzo del desarrollo cognitivo (Cuaderno del Profesor y del Alumno), basado en el modelo de Haywood, adaptándolo a nuestras necesidades y a nuestro sistema educativo. Este Programa ha sido diseñado para favorecer el des...

  18. Terapia cognitivo-comportamental da fobia social Cognitive-behavioral therapy in social phobia

    Directory of Open Access Journals (Sweden)

    Lígia M Ito

    2008-10-01

    Full Text Available OBJETIVO: Este artigo revisa aspectos relevantes da fobia social e os estágios de tratamento através da terapia cognitivo-comportamental em crianças, adolescentes e adultos. MÉTODO: A partir do banco de dados Medline, realizou-se revisão da literatura publicada a respeito do tratamento da fobia social por meio da terapia cognitivo-comportamental. RESULTADOS: Revisão da literatura sugere que a fobia social é uma condição prevalente e crônica, caracterizada por inibição social e timidez excessiva. Tanto o diagnóstico como o tratamento desse transtorno são comumente determinados pelo nível de incômodo e pelo prejuízo funcional. Estudos populacionais indicam taxas de prevalência ao longo da vida para a fobia social entre 2,5 e 13,3%. As principais técnicas utilizadas na terapia cognitivo-comportamental para a fobia social são descritas e exemplificadas em um relato de caso. CONCLUSÕES: Há consenso geral na literatura de que a terapia cognitivo-comportamental é eficaz tanto para o tratamento de jovens como de adultos com fobia social. Uma vez que a fobia social com freqüência tem início precoce, a identificação de crianças com risco acentuado para o desenvolvimento de fobia social deve ser priorizada em investigações futuras.OBJECTIVE: This article reviews relevant aspects of social phobia and the stages of treatment within cognitive-behavioral therapy in children and adolescents, as well as in adults. METHOD: A review of the literature published on the treatment of social phobia using cognitive-behavioral treatments was performed using the Medline database. RESULTS: A review of the literature suggests that social phobia is a chronic and prevalent condition, characterized by social inhibition and excessive shyness. Diagnosis and treatment of the disorder are usually determined by distress level and functional impairment. Population studies indicate that lifetime prevalence rates for social phobia range from 2.5 to 13

  19. Estilo cognitivo de dependencia-independencia de campo y proceso lector

    OpenAIRE

    Kirchner, Teresa

    1987-01-01

    Este estudio trata de determinar si se dan relaciones de covariación entre la aptitud de reestructuración (una de las manifestaciones del constructo «Dependencia-Independencia de campo» (DIC) y el proceso lector.La DIC es uno de los Estilos Cognitivos surgidos a raíz de las investigaciones que sobre la percepción de la verticalidad realizaban Witkin y Asch a finales de los años 40, y que derivó finalmente en un modelo explicativo de las diferencias individuales, basado en el grado de diferenc...

  20. Relaciones entre modos cognitivos, desvío de tipos y desempeño laboral

    OpenAIRE

    Parra Tíjaro, Jeison

    2014-01-01

    Las organizaciones requieren una gestión humana estratégica, fundamentada en la importancia del conocimiento y la capacidad interna como las principales fuentes de ventaja competitiva (Ospina Jiménez, 2010; Calderón Hernández, Cuartas Castaño yÁlvarez Giraldo, 2009) -- La presente investigación pretende describir la relación existente entre el modo cognitivo preferente y el desempeño laboral -- La corteza cerebral está dividida en cuatro macroáreas especializadas en el sentido funcional, y, s...

  1. Factores de vulnerabilidad cognitivos en mujeres víctimas de violencia doméstica

    OpenAIRE

    Ramírez Buriticá, Paula Andrea

    2011-01-01

    Ubicación en Biblioteca USB Medellín (San Benito): CD-1938t .-- Grupo de Investigación en Estudios Clínicos y Sociales en Psicología - Línea de Investigación: Perfiles Cognitivos y Psicopatología - Tema: Violencia. La violencia doméstica es un problema social de gran magnitud, tanto por la frecuencia con la que se repite como por la gravedad de los hechos y las consecuencias a la que esto conlleva, es definida como patrón de conductas abusivas que incluye un abanico de manifestaciones físi...

  2. Desarrollo cognitivo tras un traumatismo craneoencefálico en la infancia

    OpenAIRE

    Capilla, Almudena; González Marqués, Javier; Carboni Román, Alejandra; Maestú, Fernando; Paúl Lapedriza, Nuria

    2007-01-01

    Un traumatismo craneoencefálico (TCE) ocurrido durante la infancia puede incidir notablemente en el proceso de desarrollo cerebral del niño y, como consecuencia, en su desarrollo cognitivo y conductual. Sin embargo, la evolución de las capacidades cognitivas y conductuales tras un TCE en la infancia no es siempre igual, sino que depende de una serie de factores. Diversos estudios han revelado dos grupos principales de factores que interaccionan fuertemente entre sí, factores mórbidos...

  3. Nivel cognitivo de las preguntas que formulan las educadoras de párvulos

    OpenAIRE

    Tornero, Bernardita; Ramaciotti, Antonietta; Truffello, Alicia; Valenzuela, Francisca

    2015-01-01

    El objetivo principal de este estudio es identificar y clasificar en categorías y subcategorías el nivel cognitivo de las preguntas formuladas por las educadoras de párvulos durante la "hora del cuento". Para ello se confeccionó una pauta basándose en la taxonomía de Bloom adaptada por Anderson, y se observó a 63 educadoras de párvulos de segundo nivel de transición provenientes de 37 escuelas particulares subvencionadas de 7 comunas de la región metropolitana de Santiago de Chile. Los result...

  4. Perfil cognitivo y psicopatológico asociados a la conducta antisocial

    OpenAIRE

    John Jairo Cifuentes González; Nora Helena Londoño Arredondo

    2011-01-01

    El objetivo del presente estudio fue establecer los componentes del perfil cognitivo y psicopatológico que caracterizan a los individuos judicialmente condenados, discriminando además el diagnóstico de trastorno de la personalidad antisocial (TPA). Participaron 607 personas que se dividieron en dos grupos: 398 casos (con TPA) y 209 controles (sin TPA). Instrumentos: YSQ-L (Young y Brown, 1999) validado por Castrillón et al. (2005), EEC-M (Londoño et al., 2006), el MCMI-II (Millon, 1999) y la ...

  5. Relevancia e Inferencia: Procesos cognitivos propios de la comunicación humana

    Directory of Open Access Journals (Sweden)

    Constanza Moya Pardo

    2006-06-01

    Full Text Available Este artículo pretende mostrar los planteamientos cognitivos más representativos de la Teoría de la Relevancia propuesta por Spelber & Wilson con respecto al modelo ostensivo-inferencial. Este modelo plantea un mecanismo deductivo explícito que da cuenta de los procesos y estrategias que permiten el paso del significado literal a la interpretación pragmática de los mensajes en el proceso de comunicación humana.

  6. Elementos cognitivos para el análisis ergonómico del trabajo

    OpenAIRE

    Castillo-Martínez, Juan A; Universidad del Rosario, Escuela de Medicina y Ciencias de la Salud. Grupo de Investigación Salud Cognición y Trabajo

    2007-01-01

    Esta nota de investigación presenta algunos de los elementos de base para el análisis de la actividad del trabajo desde la perspectiva de la ergonomía cognitiva. Para poder aproximarse a la relación existente entre los procesos cognitivos en el trabajo y la noción de ergonomía es necesario abordar inicialmente la definición de esta disciplina. El termino ergonomía, acuñado en 1940 por el psicólogo británico Hywel Murrell, (del Griego ergo: trabajo + nomos: ley, conocimiento)...

  7. Tratamiento cognitivo-conductual de la sintomatología asociada a la menopausia

    Directory of Open Access Journals (Sweden)

    Cristina Larroy

    2004-01-01

    Full Text Available El cese definitivo de la menstruación se presenta asociado a una serie de síntomas físicos,psicológicos y sociales susceptibles de ser abordados mediante técnicas cognitivo conductuales. Enel presente trabajo se presenta un programa de intervención basado en dichas técnicas. Treintamujeres climatéricas siguieron este programa durante diez semanas. Los resultados indican que elprograma consigue la reducción de los síntomas y la mejora de la calidad de vida.

  8. Capitalismo cognitivo, trabajo informacional y un poco de música

    Directory of Open Access Journals (Sweden)

    Mariano Zukerfeld

    2008-01-01

    Full Text Available Este artículo está organizado en torno a tres secciones. En la primera, se presenta un resumen de nuestro marco teórico para pensar el capitalismo cognitivo, centrado en el concepto de bienes informacionales. En la segunda, utilizando los datos de un estudio de campo, se aplican las categorías esbozadas para caracterizar algunos aspectos del trabajo de los músicos en la actualidad. Finalmente, se extienden las ideas surgidas de la sección anterior y se propone la noción de trabajo informacional para pensar la forma de trabajo que distingue a la presente etapa.

  9. Capitalismo cognitivo, trabajo informacional y un poco de música

    Directory of Open Access Journals (Sweden)

    Mariano Zukerfeld

    2008-04-01

    Full Text Available Este artículo está organizado en torno a tres secciones. En la primera, se presenta un resumen de nuestro marco teórico para pensar el capitalismo cognitivo, centrado en el concepto de bienes informacionales. En la segunda, utilizando los datos de un estudio de campo, se aplican las categorías esbozadas para caracterizar algunos aspectos del trabajo de los músicos en la actualidad. Finalmente, se extienden las ideas surgidas de la sección anterior y se propone la noción de trabajo informacional para pensar la forma de trabajo que distingue a la presente etapa.

  10. Optimizacion en procesos cognitivos y su repercusión en el aprendizaje de la danza

    OpenAIRE

    Megías Cuenca, M. Isabel

    2009-01-01

    El presente trabajo ha pretendido, en última instancia, acercar la psicología al mundo de la danza: desde la investigación sobre los mecanismos psicológicos que subyacen a este comportamiento (danzar); pasando por la demostración de sus beneficios, también a nivel cognitivo, que repercuten en otras áreas del individuo; hasta la profundización en el proceso de enseñanza/aprendizaje de la danza para buscar la forma de optimizarlo. En su justificación teórica, esta tesis analiza exhaustivame...

  11. Empatia e aliança terapêutica sob a ótica dos terapeutas cognitivo-comportamentais

    OpenAIRE

    Araújo, Mara Lívia de

    2014-01-01

    Na abordagem cognitivo-comportamental, a empatia é considerada uma habilidade social importante para a formação de um bom relacionamento terapêutico. Considerando a importância da empatia e da aliança entre terapeuta e cliente para o progresso do tratamento psicoterapêutico o presente estudo investigou junto aos terapeutas cognitivo-comportamentais a capacidade empática pessoal por meio do Inventário de Empatia (IE) e a qualidade da relação terapêutica por meio do Inventário Co...

  12. A Influência de um protocolo de coordenação motora no estado depressivo e estado cognitivo

    OpenAIRE

    Costa, Cândida; Pinheira, Vítor; Rodrigues, Abel

    2014-01-01

    Introdução: São conhecidos os efeitos positivos do exercício terapêutico no estado depressivo e estado cognitivo do idoso. Objetivo: Este estudo teve como objetivos avaliar e comparar os efeitos de um protocolo de coordenação motora, com a duração de 8 semanas, duas vezes por semana, 50 minutos cada sessão, no estado depressivo e estado cognitivo. Metodologia: 30 idosos (81,43 ±8,97 anos), 66,7% mulheres, clinicamente estáveis e capazes de realizar marcha, numa amostra por conveniência...

  13. La metacognición como estrategia para detectar procesos cognitivos en niños con retraso mental

    OpenAIRE

    Vázquez, Ana; Suzanne, León; Rodríguez, María

    2006-01-01

    Este artículo se basa en una investigación tendiente a detectar los procesos cognitivos que empleaban los niños con retraso mental en la resolución de situaciones matemáticas, mediante el uso de estrategias metacognitivas. Se trabajó con una muestra de veinte niños con retraso mental que asisten a aulas integradas, de las provincias de Heredia y Alajuela. Se elaboró la Batería de Resolución de Situaciones matemáticas (BARSIMAR) para detectar los procesos cognitivos que empleaban los niños ant...

  14. Componentes cognitivos y afectivos en la configuración de la personalidad moral de los adolescentes

    OpenAIRE

    Palma Cortés, Javier

    2013-01-01

    La presente tesis doctoral se ha diseñado con el objetivo de analizar cómo se comportan determinados aspectos cognitivos y afectivos en el desarrollo moral y en la configuración de la personalidad moral de los adolescentes. En relación a los aspectos cognitivos se centra la investigación en la preferencia y jerarquización de los valores humanos, y en el pensamiento prosocial. Los procesos empáticos, desde su vertiente afectiva, han sido analizados como expresión del componente afectivo de la ...

  15. La atención odontológica del paciente geriátrico con deterioro cognitivo

    OpenAIRE

    M.C. Haya Fernández; I. Blasco Garrido; M.B. Cabo Pastor

    2015-01-01

    La investigación clínica ha demostrado que una mejor función cognitiva se relaciona con un mejor estado de salud oral. Y, de la misma manera, los pacientes mayores institucionalizados con deterioro cognitivo presentan una pobre salud oral con mayor número de dientes ausentes, caries, acúmulo de placa y enfermedad periodontal. El diagnóstico precoz del paciente con deterioro cognitivo es fundamental para mejorar el pronóstico de la enfermedad y poder plantear un tratamiento odontológico preven...

  16. Relación del desarrollo cognitivo con el clima familiar y el estrés de la crianza

    OpenAIRE

    Vera Noriega,José Ángel; Morales Nebuay,Dulce Karina; Vera Noriega,Cristina

    2005-01-01

    Se llevo a cabo un estudio con 120 familias en pobreza extrema de las zonas marginales de Hermosillo, Sonora México. Madres de 32 años en promedio respondieron a una escala de funcionamiento familiar, estrés de la crianza y sus niños fueron medidos en desarrollo cognitivo. El objetivo fue evaluar las diferencias significativas entre los tres tipos de familias en su desarrollo cognitivo, el estrés de la crianza y el clima familiar. Se clasificaron las familias en base a la medida de clima fami...

  17. Caracterización del potencial de abuso del flunitracepam

    OpenAIRE

    Martí de la Llave, Cecilia

    1997-01-01

    Con el presente estudio se pretende caracterizar el potencial de abuso del flunitracepam. La pauta de administración del flunitracepam está ajustada para alcanzar concentraciones máximas plasmáticas similares entre los dos regímenes de administración del fármaco activo, aunque a diferente velocidad; con la dosis única se alcanza la concentración máxima plasmática más rápidamente que con la dosis dividida. Cuando el voluntario recibe el fármaco activo a dosis única toma cinco cápsulas que ...

  18. La Ecuación de Hill con Potencial Irregular

    Directory of Open Access Journals (Sweden)

    Santiago Cambronero

    2012-03-01

    Full Text Available Se considera la ecuación de Hill cuyo potencial es la derivada formal de una función Hölder - continua de parámetro \\theta \\in (0,1 y se muestra que las soluciones de la versión discreta correspondiente convergen adecuadamente a las soluciones de la ecuación original. Este hecho se usa para establecer teoremas de existencia de soluciones para este caso singular y para deducir algunas propiedades de las soluciones y el discriminante de la ecuación estudiada.

  19. Tratamiento cognitivo conductual de la migraña en el adulto

    Directory of Open Access Journals (Sweden)

    María Elena Navarro-Calvillo

    2006-01-01

    Full Text Available El dolor crónico de la migraña es uno de los síndromes más comunes, caracterizado por dolores de cabeza recurrentes, el cual afecta al 25% de la población. El dolor es un fenómeno perceptivo que necesita un enfoque multidimencional. En la migraña, además de tener una explicación neurológica, se han encontrado correlaciones con la calidad de vida, el trabajo, el estrés o componentes de tipo psicosocial. Se han empleado en las últimas décadas tratamientos cognitivo-conductuales combinados con técnicas de relajación y retroalimentación, los cuáles han aportado resultados que aunque no del todo contundentes, son una alternativa importante para los pacientes con migraña. En este artículo se analizan las características del dolor crónico y los factores psicológicos asociados, para después hacer una revisión sobre el dolor crónico de la migraña y la efectividad del tratamiento cognitivo conductual.

  20. Oficinas de estimulação cognitiva adaptadas para idosos analfabetos com transtorno cognitivo leve

    Directory of Open Access Journals (Sweden)

    Izabel Borges dos Santos

    2012-12-01

    Full Text Available Oficinas de estimulação cognitiva para idosos analfabetos com transtorno cognitivo leve é um tema pouco pesquisado. Objetivou-se verificar a autopercepção da memória em idosos analfabetos com transtorno cognitivo leve, antes e após oficinas de estimulação cognitiva, adaptadas para analfabetos. Trata-se de uma pesquisa qualitativa, realizada na Unidade de Saúde de Taguatinga-DF, envolvendo 63 idosos: 22 no Grupo Experimental (GE, com 10 oficinas; 21 no Grupo Controle 1 (GC1, com 10 palestras; e 20 no Grupo Controle 2 (GC2, sem intervenção. Foram realizadas entrevistas semiestruturadas antes e após intervenções, perguntando-se sobre memória. Aos GE e GC1 foram oferecidas atividades semanais de duas horas. A idade média foi 72,8 anos, 92% do sexo feminino. Na pré-intervenção, 82% haviam piorado memória no último ano. Na pós-intervenção, GC1 e GC2 mantiveram alterações da memória, enquanto GE melhorou cognição. Conclui-se que as oficinas e palestras proporcionaram melhora na funcionalidade e socialização/integração.

  1. Terapia cognitivo-comportamental dos transtornos alimentares Cognitive-behavioural therapy of eating disorders

    Directory of Open Access Journals (Sweden)

    Mônica Duchesne

    2002-12-01

    Full Text Available A terapia cognitivo-comportamental é uma intervenção breve, semi-estruturada e orientada para metas, que tem sido amplamente utilizada nos centros de pesquisa e tratamento de transtornos alimentares. O presente artigo tem por objetivo descrever as principais estratégias cognitivas e comportamentais utilizadas no tratamento ambulatorial dos transtornos alimentares. Vários ensaios clínicos avaliaram a eficácia da terapia cognitivo-comportamental, indicando que ela favorece a remissão ou diminuição da freqüência de episódios de compulsão alimentar, dos comportamentos purgativos e da restrição alimentar. Tem sido relatada também melhora do humor, do funcionamento social, e diminuição da preocupação com peso e formato corporal.The cognitive-behavioural therapy is a brief, semi-structured and goal oriented intervention, which has been largely used in research and treatment centers specialized on eating disorders. The present article describes the main cognitive and behavioral strategies used in the outpatient treatment of eating disorders. Several clinical studies assessed the effectiveness of cognitive-behavioural therapy, indicating the remission or the reduction of the frequency of binge eating episodes, purgative behaviours and food restriction. Social and mood improvement, as well as reduction of weight and body shape concerns, have also been reported.

  2. Perfil cognitivo de niños con rendimientos bajos en comprensión lectora

    Directory of Open Access Journals (Sweden)

    Lorena Canet-Juric

    2013-10-01

    Full Text Available La mayoría de los niños con dificultades en la comprensión lectora poseen rendimientos inferiores en un conjunto de procesos cognitivos. El objetivo del presente estudio es establecer un perfil cognitivo asociado al bajo rendimiento en comprensión lectora en relación a la habilidad de monitoreo, a la producción de inferencias, al vocabulario, a la amplitud de memoria de trabajo y a la capacidad inhibitoria, en niños hispanoparlantes. Para ello se administraron tareas correspondientes a dichos procesos en niños con altos y bajos rendimientos en comprensión lectora. Los resultados mostraron que si bien los niños con mala comprensión presentan bajos rendimientos en estas habilidades, no puede establecerse un perfil consistente ya que hay niños con problemas en comprensión que presentan normal o superior rendimiento en algunas de estas habilidades cognitivas.

  3. Emancipatorni potencial gibanj v vstajah v Sloveniji 2012–2013

    Directory of Open Access Journals (Sweden)

    Lana Zdravković

    2016-09-01

    Full Text Available Prispevek premišljuje emancipatorni potencial gibanj v vstajah 2012–2013, najbolj silovitih v zgodovini samostojne Slovenije. Ne glede na njihovo organizacijsko obliko (iniciativa, kolektiv, neformalno združenje, društvo, zavod, politična stranka …, čas nastanka ali številčnost je v središču predvsem njihovo razumevanje politike in potencial za razvoj strategij za politično delovanje. Pri tem avtorica izhajam iz temeljnega aksioma, da resen premislek o politiki nujno vključuje premislek o temeljni radikalni enakosti med ljudmi, to je politiki emancipacije, ki ji je inherentna egalitarna norma. Analiza temelji na intervjujih s sogovorniki iz 19 gibanj, aktivnih v času vstaj, in pokaže na nasprotja, ki so se vzpostavila med gibanji znotraj paradigme »možnega«, kjer je politika razumljena kot vladavina, in tista na področju »nemožnega«, to je izumljanja prostorov politike, ki bi temeljili na radikalni enakosti onkraj boja za oblast.

  4. Processamento Cognitivo no Transtorno de Estresse Pós-Traumático: Um Estudo Teórico

    Directory of Open Access Journals (Sweden)

    Gabriela Sbardelloto

    2012-12-01

    Full Text Available O presente artigo discute o processamento cognitivo no Transtorno de Estresse Pós-Traumático (TEPT através das teorias mais relevantes relacionadas ao desenvolvimento e manutenção do TEPT: Teoria dos Dois Fatores, Teoria do Processamento Emocional, Teoria da Representação Dual e Teoria Cognitiva de Ehlers e Clark. A partir disso, discute-se a relação entre o processamento cognitivo da experiência traumática e o desencadeamento, a manutenção e o agravamento dos sintomas pós- traumáticos. As abordagens apresentam modelos explicativos sobre o processamento da memória traumática, enfatizando fatores que ocorrem antes, durante e depois do trauma. Verifica-se a necessidade de pesquisas empíricas acerca do processamento cognitivo no TEPT, esforço que vem a contribuir com hipóteses explicativas mais precisas que implicam em intervenções efetivas no TEPT. Palavras-chave: transtorno de estresse pós-traumático; processamento cognitivo; implicações clínicas.

  5. Eficacia de un programa de entrenamiento en memoria en el mantenimiento de ancianos con y sin deterioro cognitivo

    Directory of Open Access Journals (Sweden)

    M.ª Dolores Calero García

    2006-01-01

    Full Text Available El objetivo del este estudio ha sido analizar el efecto de un entrenamiento en memoria en el mantenimiento cognitivo de ancianos con y sin deterioro cognitivo. Método: En la investigación han participado 98 ancianos (59 grupo tratamiento y 39 grupo control que han sido evaluados en tres momentos temporales (antes del entrenamiento, después del mismo y tras 9 meses con diversas pruebas de funcionamiento cognitivo. Las personas del grupo tratamiento han participado en un programa de entrenamiento en memoria de 14 sesiones. Resultados: Los resultados muestran que los ancianos del grupo tratamiento mejoran su rendimiento cognitivo en las evaluaciones posteriores al entrenamiento mientras que las del grupo control sufren un declive de tal manera que, aunque no existen diferencias significativas de partida entre grupos, éstas sí que se producen una vez introducida la fase de entrenamiento. Conclusiones: los resultados muestran los efectos positivos de este tipo de intervenciones cuando se trabaja con población anciana.

  6. Rastreio cognitivo em pacientes com acidente vascular cerebral: um estudo transversal

    Directory of Open Access Journals (Sweden)

    Ana Amália Torres Souza Gandour Dantas

    2014-07-01

    Full Text Available Objetivo O estudo objetivou-se a fazer um rastreio cognitivo nos pacientes com acidente vascular cerebral (AVC, a fim de determinar pontos de corte de acordo com a idade, escolaridade e grau de comprometimento neurológico. Métodos Foi realizado um estudo transversal no qual participaram 109 pacientes ambulatoriais, sendo 61 homens, com média da idade de 59 anos (± 11, média do tempo de escolaridade de 5 anos (± 4 e do tempo de sequela de 16 meses (± 14. Os pacientes foram avaliados por meio do Miniexame do Estado Mental (MEEM e pela National Institute of Health Stroke Scale. Os dados foram analisados pela regressão linear múltipla (stepwise forward. Resultados Verificou-se que as variáveis grau de comprometimento neurológico, idade e escolaridade contribuíram significativamente para o valor global do MEEM e explicaram a variância do estado cognitivo (R2 ajustado = 0,24. Cada aumento do comprometimento neurológico representou diminuição de 0,456 no escore do MEEM. Quanto maior a idade, ocorreu uma diminuição de 0,202 no MEEM, e à medida que diminui o tempo de escolaridade, houve uma diminuição de 0,190 no MEEM. Os pontos de corte variaram de 14 a 22 de acordo com o grau de comprometimento neurológico, idade e escolaridade. Conclusão Os resultados apontaram que, por meio do rastreio positivo de déficit cognitivo, foram encontrados pontos de corte associados ao comprometimento neurológico, necessitando também serem ajustados pela idade e escolaridade, sugerindo que essas associações sejam preferencialmente levadas em consideração na planificação da reabilitação neuropsicológica dos pacientes com AVC.

  7. EFECTO DEL “PROGRAMA COGNITIVO CONDUCTUAL CAMINOS” PARA MEJORAR LA RESILIENCIA EN LAS ADOLESCENTES DE LA CASA HOGAR “TORRE FUERTE” - 2015

    OpenAIRE

    MELÉNDEZ VILCA, ERIKA ANGÉLICA

    2016-01-01

    CONCEPTO DE PROGRAMA DE INTERVENCIÓN PROGRAMAS DE INTERVENCIÓN Y LA RESILIENCIA PROGRAMA COGNITIVO-CONDUCTUAL Y LA RESILIENCIA ¿QUÉ ES UN “PROGRAMA COGNITIVO CONDUCTUAL CAMINOS”? CÓMO APLICAR EL “PROGRAMA COGNITIVO CONDUCTUAL CAMINOS” TIPOS DE PROGRAMAS DE INTERVENCIÓN OTRAS INTERVENCIÓNES DE RESILIENCIA EN POBLACIÓN ADOLESCENTE Y OTRAS EDADES RESILIENCIA ORÍGENES DEL CONCEPTO RESILIENCIA CONCEPTO DE RESILIENCIA LA RESILIENCIA COMO PROCESO PSICOLÓGICO. APORTES TEÓRICOS LA RESILIENCIA Y LA SAL...

  8. Estudio comparativo de las teorías de desarrollo cognitivo de Piaget y Flavell en niños preescolares

    OpenAIRE

    Saquicela Novillo, Claudia Elisa

    2010-01-01

    La tesis es un análisis comparativo y contraposición entre la teoría de Piaget con la teoría de Flavell sobre el desarrollo cognitivo en niños preescolares para comprender teóricamente tanto las ideas de Piaget como aquello propuesto por Flavell, en cuanto a cuatro categorías conceptuales: etapas de desarrollo cognitivo, génesis del pensamiento, mecanismos y estrategias de desarrollo cognitivo. Luego se presentan algunas implicaciones y directrices educativas que se han desprendido deputes...

  9. Potencial zeta de sulfatos de de bario y de estroncio

    OpenAIRE

    Delgado M., Edgar

    2010-01-01

    Por medio de la electroforesis se determinó las movilidades electroforéticas y los potenciales zeta del sulfato de bario a 25,0 °C como función de la fuerza iónica de NaCI, así como del Sulfato de estroncio en función de la fuerza iónica del cloruro de sodio y del pH. Se encontró que el amento de la fuerza iónica de NaCI causa un cambio del Potencial Zeta negativo del sulfato de estroncio a positivo con valor cero a aprox. 0,06 de fuerza iónica. El P.Z. del sulfato de estroncio es positivo...

  10. Geothermal potential in Mexico; Potencial geotermico de la republica mexicana

    Energy Technology Data Exchange (ETDEWEB)

    Ordaz Mendez, Christian Arturo; Flores Armenta, Magaly; Ramirez Silva, German [Comision Federal de Electricidad, Gerencia de Proyectos Geotermoelectricos, Morelia, Michoacan (Mexico)]. E-mail: christian.ordaz@cfe.gob.mx

    2011-01-15

    parte de la estrategia de la CFE para incrementar la generacion de energia electrica mediante fuentes no convencionales llevo a cabo un calculo del potencial geotermico del pais. Este calculo se efectuo a traves del inventario nacional de manifestaciones termales con que cuenta la GPG, el cual ha permitido identificar 1380 manifestaciones termales distribuidas en todo el pais, con informacion de las temperaturas tomadas superficialmente y las temperaturas obtenidas por medio de geotermometros. El calculo del potencial geotermico se hizo con base en la clasificacion de estas manifestaciones por rangos de temperatura geotermometrica, obteniendose asi recursos de alta, media y baja entalpia. Posteriormente se utilizo el metodo volumetrico para obtener el potencial geotermico nacional. Los resultados indican que para las Reservas Posibles los recursos de alta entalpia ascienden a 5691 MWe, para los de moderada entalpia son de 881 MWe y los de baja entalpia de 849 MWe dando un total de 7422 MWe. Por otra parte, las Reservas Probables para el recurso de alta entalpia son de 1643 MWe, para los de moderada entalpia de 220 MWe y para los de baja entalpia de 212 MWe dando un total de 2077 MWe. Por ultimo las Reservas Probadas se tomaron como la capacidad adicional que puede instalarse en cada uno de los campos geotermicos conocidos, dando un total de 186 MWe. La informacion se proceso y se integro por medio del Sistema de Informacion Geografica (SIG) ArcGis 9.2 (c), dando como resultado la publicacion via Intranet del Mapa del Potencial Geotermico de la Republica Mexicana.

  11. Psicoterapia cognitivo analítica y trastornos de la personalidad: revisión

    Directory of Open Access Journals (Sweden)

    Laura Rodríguez Moya

    2013-06-01

    Full Text Available En los años 80 y 90, A. Ryle desarrolló un modelo de tratamiento denominado Psicoterapia Cognitivo Analítica (PCA. Con un enfoque integrador, breve y focal, la PCA se ha aplicado a diversas patologías, siendo su uso más frecuente con pacientes con trastorno de personalidad, sobre todo con trastorno límite. Estos pacientes poseen un número de disfunciones metacognitivas que dificultan el proceso de darse cuenta de sus diferentes estados mentales y de sus componentes. A través del modelo de Múltiples Estados del self, el objetivo es ayudar al paciente a identificar los procesos disfuncionales o restrictivos del self que está experimentando y dotarle de recursos para que pueda sustituirlos por otros más adaptativos.

  12. Hacia un análisis cognitivo del cambio conductual: el comportamiento social pro activo

    Directory of Open Access Journals (Sweden)

    Manolete S. Moscoso

    1996-06-01

    Full Text Available Este artículo presenta un análisis del Comportamiento Social Pro Activo utilizando como modelo la teoría del aprendizaje social. Se revisa el concepto de autoeficacia, originalmente propuesto por Bandura, y se hace referencia a variables de tipo cognitivo tales como los sistemas de valores y creencias. Se examinan las distinciones entre el temor al fracaso, al éxito, al rechazo, y su relación con el proceso de autosabotaje. Asimismo se discute la importancia de la transformación del significado y sus beneficios en la extinción del temor. Se presenta un modelo conceptual del control de los estados emocionales y sus implicancias en el proceso de la acción. Finalmente, se describen las premisas fundamentales del Condicionamiento Neurofisiológico Asociativo como un programa terapéutico que facilita el manejo de los estados emocionales de la persona.

  13. LA UNIDAD DE LO COGNITIVO Y LO AFECTIVO EN LA HISTORIA

    Directory of Open Access Journals (Sweden)

    Ángel Felipe Jevey Vázquez

    2010-07-01

    Full Text Available El desarrollo que las ciencias han alcanzado en los últimos años ha generado nuevas investigaciones sobre diferentes esferas en ciencias más particulares. Por ejemplo la Psicología, cada una de estas nuevas áreas han tenido que determinar su objeto de estudio, en el caso particular, que nos atañe en esta reflexión, la Psicología Infantil. Durante muchos años, en la literatura psicológica se han presentado como dos aspectos independientes, los procesos cognitivos y afectivos del estudio de la personalidad, en el presente artículo los autores se proponen ver los vínculos que existen entre ambos, fundamentalmente desde la asignatura Historia, al utilizar como punto de partida la categoría tiempo.

  14. Potencial solar activo en techumbres de viviendas inmobiliarias

    Directory of Open Access Journals (Sweden)

    Esteban Felipe Zalamea León

    2016-06-01

    Full Text Available El presente artículo analiza las características geométricas de las techumbres de viviendas unifamiliares pertenecientes a conjuntos inmobiliarios recientes en Concepción (Chile y su potencial de captación solar. Para ello, se ejecuta un registro de 2.139 casas construidas posteriores al año 2006, correspondientes a 68,3% del total. Al describir las cubiertas existentes, se detecta una superficie media de techumbre inclinada de 84,7 m2 y fragmentada, entre 3 y 12 alas o faldones, con inclinación media de 37,48°, que generan al menos un ala mayor o secundaria con superficie promedio de 33,9 m2 orientada al norte, este u oeste. Esta superficie recibe una radiación anual total de entre 954 kWha/m2 a 1.732,8 kWha/m2, según azimut e inclinación, lo que con paneles fotovoltaicos integrados produce potencialmente una media de 6.317,4 kWha. Además, se estudian casos extremos acorde a máxima y mínima superficie captadora por superficie construida, demostrando que la producción energética alcanzaría a abastecer eléctricamente con la tecnología fotovoltaica (PV integrada. Finalmente, se evalúa el potencial de la tecnología híbrida térmica-fotovoltaica con fluido calotransportador de aire (PVTa. 

  15. Ribonucleasas: su potencial terapéutico en infecciones virales

    Directory of Open Access Journals (Sweden)

    Xiomara Úsuga

    2006-07-01

    Full Text Available En la actualidad existe un gran interés por identificar proteínas o péptidos antimicrobianos que puedan ser herramientas terapéuticas que eviten el establecimiento o permitan el control de diferentes infecciones. Las ribonucleasas (RNasas, pertenecientes a la superfamilia Ribonucleasa A, son enzimas que participan en varios procesos fisiológicos, que van desde el procesamiento alternativo del RNA hasta la angiogénesis. Estas enzimas son expresadas por diferentes tejidos y exhiben especificidades variables contra diferentes sustratos de RNA. El potencial terapéutico de las RNasas se ha sugerido en procesos oncogénicos; adicionalmente, se ha descrito que tienen actividad antiviral directa y el potencial de activar células del sistema inmune innato induciendo su maduración y la producción de citoquinas proinflamatorias. Nuestro grupo de investigación ha realizado estudios que señalan la capacidad de cuatro RNasas recombinantes: EDN, -4EDN, RNasa A y angiogenina de inhibir la replicación del virus de la inmunodeficiencia humana tipo 1 en linfocitos T de sangre periférica activados. En este artículo se revisará la clasificación de las ribonucleasas que constituyen la superfamilia RNasa A y se describirá, en forma detallada, lo que se conoce de la función biológica, acción antiviral y mecanismo de acción de las RNasas a las que se les ha reportado actividad antiviral.

  16. Potencial forrageiro de novos clones de capim-elefante

    Directory of Open Access Journals (Sweden)

    Botrel Milton de Andrade

    2000-01-01

    Full Text Available O objetivo deste trabalho foi avaliar o comportamento de novos clones selecionados de capim-elefante. O experimento foi realizado na Embrapa Gado de Leite, em Coronel Pacheco -- MG, por um período de dois anos. Foi avaliado o potencial forrageiro de 20 clones de capim-elefante, obtidos pelo programa de melhoramento, e mais duas cultivares tradicionais (Cameroon e Taiwan A-146 usadas como testemunhas. O delineamento experimental foi o de blocos ao acaso com quatro repetições. As adubações para estabelecimento e manutenção foram realizadas de acordo com a análise do solo, visando suprir as exigências nutricionais do capim-elefante. Observaram-se diferenças significativas entre os clones, quanto ao potencial para produção de forragem, à relação folha/colmo e ao perfilhamento aéreo e basal. A maioria dos clones avaliados apresentou maior produção de matéria seca que as cultivares tradicionais, Cameroon e Taiwan A-146, durante o período seco e chuvoso. Não houve diferença significativa no teor de proteína bruta da matéria seca das cultivares controles (Cameroon e Taiwan A-146 e dos clones avaliados, em ambas as estações (águas e seca. O clone F 27-01, lançado pela Embrapa Gado de Leite com o nome de cultivar Pioneiro, destacou-se para quase todas as características agronômicas estudadas.

  17. PREJUÍZOS COGNITIVOS EM IDOSOS COM DIABETES MELLITUS TIPO 2

    Directory of Open Access Journals (Sweden)

    Regina Maria Fernandes Lopes

    2009-01-01

    Full Text Available El avance en las condiciones de salud propicia el progresivo aumento de la esperanza de vida. Estudios han identificado la existencia de una conexión entre la Diabetes Mellitus (DM y demencia. La hiperglicemia podría ser un factor importante en la incidencia de la enfermedad de Azheimer, la cual puede ser una causa secundaria de demencia. La diabetes mellitus tipo 2 (DM2 está asociada con déficits cognitivos y funcionales, y el WCST es una de las herramientas que puede ser utilizada para evaluar funcionamiento ejecutivo. El objetivo de este estudio fue evaluar los déficits cognitivos de ancianos con diabetes mellitus tipo 2. Los participantes fueron 254 ancianos de ambos sexos, mayores de 60 años; 44 de ellos diagnosticados de DM2 y 210 en un grupo control de población general. El diseño fue un estudio cuantitativo transversal. Los instrumentos utilizados fueron: datos sociodemográficos, WCST, MMSE, BDI, BAI, GD, junto a las Sub pruebas de: Vocabulario, códigos, números y Cubos del WAIS-III. Los resultados mostraron una diferencia significativa en el desempeño de los ancianos con diabetes tipo 2 en comparación con el grupo control en cuatro descriptores de WCST que indicaban un deterioro. Igualmente los ancianos con diabetes tipo 2 mostraron una intensidad de síntomas depresivos y de ansiedad estadísticamente mayor que el grupo control

  18. Cognitive and emotional effects of occupational stress in nursing professionals Efectos cognitivos y emocionales del estrés ocupacional en profesionales de enfermería Efeitos cognitivos e emocionais do estresse ocupacional em profissionais de enfermagem

    Directory of Open Access Journals (Sweden)

    Bruna Paschoalini

    2008-01-01

    Full Text Available OBJECTIVE: Investigating the indicators of stress, anxiety, depression and the cognitive changes in members of the nursing team at Santa Casa de Misericórdia de Assis SP. METHODS: 66 nursing professionals participated in the study, evaluated by psychological and cognitive tracking instruments. RESULTS: The stress experience was not homogenous in the nursing team; high scores in the depression tracking were associated to low cognitive scores. CONCLUSION: Nursing auxiliaries and technicians were affected by stress. Therefore, worker's healthcare should be provided for the whole nursing team.OBJETIVOS: Investigar, de forma integrada, posibles indicadores de alteraciones cognitivas, depresión, ansiedad y agentes estresores ocupacionales en auxiliares y técnicos de enfermería así como de enfermeros de diversos sectores de la Santa Casa de Misericordia de Asís-SP, por medio de instrumentos de rastreo psicológico y cognitivo. MÉTODOS: Participaron en el estudio 66 profesionales de enfermería, evaluados por instrumentos de rastreo psicológico y cognitivo. RESULTADOS: La experiencia de estrés no fue homogénea en el equipo de enfermería; los escores altos en el rastreo de depresión fueron asociados a escores cognitivos bajos. CONCLUSIÓN: Los auxiliares y técnicos de enfermería y enfermeros se vieron afectados por el estrés por lo que la atención a la salud del trabajador, debe ser ofrecida a todo el equipo de enfermería.OBJETIVOS: Investigar, de forma integrada, possíveis indicadores de alterações cognitivas, depressão, ansiedade e agentes estressores ocupacionais em auxiliares e técnicos de enfermagem e enfermeiros de diversos setores da Santa Casa de Misericórdia de Assis-SP, por meio de instrumentos de rastreio psicológico e cognitivo. MÉTODOS: Participaram do estudo 66 profissionais de enfermagem, avaliados por instrumentos de rastreio psicológico e cognitivo. RESULTADOS: A experiência de estresse não foi homogênea na

  19. Gallic acid-capped gold nanoparticles inhibit EGF-induced MMP-9 expression through suppression of p300 stabilization and NFκB/c-Jun activation in breast cancer MDA-MB-231 cells.

    Science.gov (United States)

    Chen, Ying-Jung; Lee, Yuan-Chin; Huang, Chia-Hui; Chang, Long-Sen

    2016-11-01

    Triple-negative breast cancers (TNBCs) are highly invasive and have a higher rate of distant metastasis. Matrix metalloproteinase-9 (MMP-9) plays a crucial role in EGF/EGFR-mediated malignant progression and metastasis of TNBCs. Various studies have revealed that treatment with gallic acid down-regulates MMP-9 expression in cancer cells, and that conjugation of phytochemical compounds with gold nanoparticles (AuNPs) increases the anti-tumor activity of the phytochemical compounds. Thus, the effect of gallic acid-capped AuNPs (GA-AuNPs) on MMP-9 expression in EGF-treated TNBC MDA-MB-231 cells was analyzed in the present study. The so-called green synthesis of AuNPs by means of gallic acid was performed at pH10, and the resulting GA-AuNPs had spherical shape with an average diameter of approximately 50nm. GA-AuNPs notably suppressed migration and invasion of EGF-treated cells, and inhibited EGF-induced MMP-9 up-regulation. GA-AuNPs abrogated EGF-induced Akt/p65 and ERK/c-Jun phosphorylation, leading to down-regulation of MMP-9 mRNA and protein expression in EGF-treated cells. Meanwhile, EGF-induced p300 stabilization was found to be involved in MMP-9 expression, whereas GA-AuNPs inhibited the EGF-promoted stability of the p300 protein. Although GA-AuNPs and gallic acid suppressed EGF-induced MMP-9 up-regulation via the same signaling pathway, the effective concentration of gallic acid was approximately 100-fold higher than that of GA-AuNPs for inhibition of MMP-9 expression in EGF-treated cells to a similar extent. Collectively, our data indicate that, in comparison with gallic acid, GA-AuNPs have a superior ability to inhibit EGF/EGFR-mediated MMP-9 expression in TNBC MDA-MB-231 cells. Our findings also point to a way to improve the anti-tumor activity of gallic acid. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. Potencial zeta de sulfatos de de bario y de estroncio

    Directory of Open Access Journals (Sweden)

    Edgar Delgado M.

    2010-06-01

    Full Text Available Por medio de la electroforesis se determinó las movilidades electroforéticas y los potenciales zeta del sulfato de bario a 25,0 °C como función de la fuerza iónica de NaCI, así como del Sulfato de estroncio en función de la fuerza iónica del cloruro de sodio y del pH. Se encontró que el amento de la fuerza iónica de NaCI causa un cambio del Potencial Zeta negativo del sulfato de estroncio a positivo con valor cero a aprox. 0,06 de fuerza iónica. El P.Z. del sulfato de estroncio es positivo a pH inferiores a aprox. 2,5 y negativo a pH superiores. El sulfato de bario presenta P.Z. negativas a fuerza iónicas de NaCI inferiores a aprox. 0.06 y PZ positivos a fuerzas iónicas mayores

  1. Evaluación de la prueba de la moneda peruana en el tamizaje de trastorno cognitivo en adultos mayores

    Directory of Open Access Journals (Sweden)

    Teodoro J Oscanoa

    2016-01-01

    Full Text Available Objetivos. Adaptación peruana del test de la moneda en el tamizaje de trastorno cognitivo en adultos mayores (>60 años. Materiales y métodos. El presente es un estudio de fase I de evaluación de prueba diagnóstica con muestreo de conveniencia y calculo de sensibilidad y especificidad, con una prevalencia pretest de 50%. Para la definición operacional de pacientes con trastorno cognitivo se utilizó los criterios de la DSM IV (The Diagnostic and Statistical Manual of Mental Disorders y el Global Deterioration Scale (GDS (controles: GDS 1 y 2; casos: mayor de 2. Para encontrar el punto de corte se utilizó la curva ROC (Receiver Operating Characteristic. Resultados. Los pacientes estudiados fueron 42 casos y 42 controles, no hubo diferencia significativa entre la edad (77,88 + 6,01 y 76,14 + 6,49 años y años de educación (13,69 + 3,70 y 8,17 + 4,71. La versión peruana del "eurotest" denominada "prueba de la moneda peruana" tiene una sensibilidad de 90,5% y especificidad de 83,3 % con punto de corte de 24. Conclusiones. La versión peruana adaptada del "eurotest", denominada "prueba de la moneda peruana" podría ser útil en el tamizaje de trastorno cognitivo de adultos mayores.

  2. Déficits cognitivos y abordajes terapéuticos en parálisis cerebral infantil

    Directory of Open Access Journals (Sweden)

    Vega Muriel

    2014-06-01

    Full Text Available Objetivo: La parálisis cerebral infantil (PC está asociada a alteraciones en las capacidades visoperceptivas, déficits atencionales y disfunción ejecutiva. Conocer su repercusión sobre la capacidad funcional y posibles planes terapéuticos, ayuda a mejorar su calidad de vida. Método: Se ha realizado una búsqueda en la literatura sobre la definición, clasificación, perfiles cognitivos y especialmente sobre la estimulación cognitiva en niños con PC. Resultados: Estimular el desarrollo cognitivo para mejorar la calidad de vida, conducta y funcionalidad de estos niños puede dar lugar a cambios en la neuroplasticidad. La integración de estas técnicas, intervención en el habla y tratamiento fisioterapéutico puede mejorar la cognición y motivación en niños con PC. Conclusiones: Los niños con PC y déficits cognitivos se pueden beneficiar de la estimulación cognitiva para mejorar su calidad de vida. Los profesionales clínicos deben brindar una intervención terapéutica centrada en el niño con PC e incluir, la escuela y el entorno familiar.

  3. El enfoque cognitivo en la ciencia y el problema de la historicidad: caracterización desde los conceptos

    Directory of Open Access Journals (Sweden)

    Wenceslao J. González

    2011-05-01

    Full Text Available Tiene dificultades el enfoque cognitivo para afrontar el problema de lahistoricidad. Esto es relevante porque la historicidad atañe a tres nivelessucesivos: la Ciencia, los agentes y la propia realidad investigada (sobretodo, social y artificial. Visto el problema de la historicidad desdelos conceptos, la clave está en poder afirmar que hay de hecho unahistoricidad en el contenido cognitivo, pero que el carácter histórico–en cualquiera de los tres niveles señalados– no es incompatible con laobjetividad.Primero se atiende al contexto del problema de la historicidad en el ámbitodel cognitivismo. Esto conecta con cuestiones sobre la especificidaddel contenido y el papel del sujeto cognoscente. Después se profundizaen cómo se ha de entender el cambio de contenido cognitivo.Esta tarea se realiza aquí mediante la consideración de las revolucionesconceptuales en la ciencia. Más tarde, se acude al cometido de los conceptos,en cuanto nexo con lo histórico concreto, ya que los investigadoresutilizan conceptos para hacer inteligible lo real que cambia. Finalmente,se hacen consideraciones sobre los planteamientos de los principalesautores analizados, para evaluar sus aportaciones.

  4. Procesos básicos en una aproximación cognitivo-conductual a los trastornos de personalidad

    Directory of Open Access Journals (Sweden)

    Miguel Ángel Pérez Nieto

    2007-01-01

    Full Text Available El presente trabajo pretende revisar el protagonismo de procesos psicológicos básicos en la actual conceptualización de los trastornos de personalidad (TTPP, sus modelos explicativos más relevantes y las terapias cognitivo-conductuales centradas en estos trastornos. Para ello se revisará la tendencia actual a una aproximación más dimensional que categorial a los TTPP señalando la mayor relevancia implícita que en esa perspectiva tendrán los procesos psicológicos básicos. Para revisar el protagonismo de estos procesos se presentarán distintos modelos teóricos: el modelo de los siete factores, la aproximación desde el modelo de los cinco grandes, el modelo biosocial, y aproximación desde los modelos cognitivos. También se presentarán los principios de las dos terapias cognitivo-conductuales propias de los TTPP. Una vez presentado el estado actual de la cuestión se revisa el papel de la percepción, la atención, la memoria, el aprendizaje, la emoción y la impulsividad y su afrontamiento y regulación en la los modelos y terapias cognito-conductuales presentados, discutiendo sobre la necesidad de darles mayor protagonismo.

  5. As terapias cognitivo-comportamentais no tratamento da bulimia nervosa: uma revisão

    Directory of Open Access Journals (Sweden)

    Tatiana A. Bertulino da Silva

    2015-06-01

    Full Text Available Objetivo Realizar uma revisão na literatura sobre a utilização da terapia cognitivo-comportamental (TCC no tratamento da bulimia nervosa entre 2009 e 2013. Métodos Três bases de dados eletrônicas foram pesquisadas, considerando artigos em língua inglesa, espanhola e portuguesa. Resultados Após as análises e exclusão dos artigos, seguindo o método PRISMA, foram selecionados 20 artigos. Os artigos selecionados foram produzidos ou na Europa ou nos Estados Unidos, em língua inglesa. Os diagnósticos da amostra variaram de exclusivamente bulimia nervosa (60% aos que incluíram pessoas com transtorno de compulsão alimentar (35%, além de diagnósticos mistos (5%. Os estudos foram, em sua maioria, realizados em mulheres adultas. A TCC, em sua abordagem clássica no consultório, foi utilizada em todos os artigos, ora utilizada individualmente, ora comparada com outras intervenções (internet, CD-ROM e autoajuda. Encontrou-se como resultado que a TCC diminui os sintomas de compulsão alimentar e de purgação, além de oferecer ganhos secundários aos participantes, como melhora de sintomas depressivos, de ansiedade e até mudanças na personalidade. As outras intervenções pesquisadas obtiveram bons resultados na modificação dos sintomas, demonstrando que há um novo caminho a ser galgado com essas novas formas de tratamento. Conclusão O tratamento da bulimia nervosa possui evidências suficientes para que seja realizado com a terapia cognitivo-comportamental. Além dela, intervenções psicoterápicas inovadoras baseadas na TCC clássica apresentam bons indicativos de eficácia. Futuras pesquisas sobre essas diferentes intervenções são necessárias.

  6. Terapia cognitivo-comportamental da fobia social: modelos e técnicas

    Directory of Open Access Journals (Sweden)

    Gustavo J. Fonseca D'El Rey

    2006-08-01

    Full Text Available A fobia social é um dos transtornos mentais mais prevalentes na população geral. As principais formas de tratamento são a psicoterapia e a farmacoterapia. Este artigo tem como objetivo realizar uma breve revisão bibliográfica dos mais importantes modelos e técnicas cognitivas e comportamentais da fobia social. Os modelos antigos - modelo de déficit de habilidades sociais, modelo de crenças irracionais, modelo da vulnerabilidade cognitiva e os modelos integrativos - serão revisados brevemente. Serão apresentadas as técnicas de tratamento - como a exposição, reestruturação cognitiva, técnicas de relaxamento e treino de habilidades sociais. Estudos de metaanálise sobre a eficácia da terapia cognitivo-comportamental no tratamento da fobia social também serão descritos.La fobia social es uno de los trastornos mentales más prevalentes en la población general. Las principales formas de tratamiento son la psicoterapia y la farmacoterapia. Este artículo posee como objetivo realizar una breve revisión bibliográfica de los más importantes modelos y técnicas cognitivas y comportamentales de la fobia social. Los modelos antiguos - modelo de déficit de habilidades sociales, modelo de creencias irracionales, modelo de la vulnerabilidad cognitiva y los modelos integrativos - serán revisados brevemente. Serán presentadas las técnicas de tratamiento - como la exposición, reestructuración cognitiva, técnicas de relajamiento y entrenamiento de habilidades sociales. Estudios de metaanálisis sobre la eficacia de la terapia cognitivo-comportamental en el tratamiento de la fobia social también serán descritos.Social phobia is a widespread mental disorder in the general population. The main forms of treatment are psychotherapy and pharmacotherapy. This article has as objective to carry out a brief bibliographical review of the most important cognitive and behavior models and techniques of social phobia. The old models - social

  7. POTENCIAL SOCIAL DO MUNICÍPIO DE SILVEIRA MARTINS, RS: CONTRIBUIÇÃO AO ZEE

    Directory of Open Access Journals (Sweden)

    Franciele Francisca Marmentini Rovani

    2016-06-01

    Full Text Available Esta pesquisa consistiu em identificar e diagnosticar as potencialidades sociais do município de Silveira Martins/RS, segundo a metodologia proposta por Becker e Egler (1996 para o Zoneamento Ecológico-Econômico (ZEE. Deste modo, utilizou-se como base cartográfica os setores censitários do município e dados referentes à economia, educação, política e saneamento básico. Com base nas informações elaborou-se um banco de dados e por meio da álgebra de mapas ponderou-se os indicadores em valores de alto, médio e baixo potencial de acordo com o potencial natural, humano, produtivo e institucional, derivando o mapa de potencial social. No município de Silveira Martins predomina o potencial mediano na maioria dos indicadores analisados, isto significa que não foi evidenciado potencial alto ou baixo. Verificou-se que o município apresenta equilíbrio entre as restrições territoriais e o potencial de expansão produtivo. Isso pode ser considerado como um aspecto positivo e com políticas públicas o desenvolvimento sustentável poderá ser intensificado.

  8. TRASTORNO LÍMITE DE PERSONALIDAD: Tratamiento desde un enfoque Cognitivo Conductual

    Directory of Open Access Journals (Sweden)

    Tamara E. Torres G.

    2007-01-01

    Full Text Available El Trastorno Límite de Personalidad (TLP ha sido u n desafió constante para los profesionales por la variabilidad sintomática que presenta, lo qu e conlleva dificultades en su diagnóstico y tratamiento. Además, ha aumentado su prevalencia en el último tiempo por lo que la importancia de trabajar este trastorno tanto a nivel de diagnós tico como psicoterapéutico debe ser acogido por profesionales de vasta experiencia y por los que es tán en el transcurso de su formación para poder lograr un mejor ejercicio profesional y ético con e stos pacientes, sin caer en diagnósticos y tratamientos erróneos como ocurrió en épocas anter iores. El enfoque Cognitivo Conductual ha demostrado grand es avances, tanto en la identificación como en la mejoría de estos pacientes, integrando u na Reestructuración Cognitiva, postulada por Aaron Beck, como tomando los aportes de la Terapia Comportamental Dialéctica propuesta por Marsha Linehan. En este escrito se mencionarán los criterios diagnó sticos y el aporte en el tratamiento del TLP en base a los dos autores anteriormente mencionados.

  9. Relación entre neandertales y cromañones: un enfoque cognitivo

    Directory of Open Access Journals (Sweden)

    Ángel RIVERA ARRIZABALAGA

    2009-08-01

    Full Text Available RESUMEN: En el presente trabajo se analizarán las diferencias de las dos poblaciones humanas que vivieron en Europa durante el inicio del Paleolítico Superior, desde un punto de vista cognitivo y cultural. La meta que se persigue es una mejor comprensión sobre la relación biológica que pudo existir entre ellos, así como las capacidades cognitivas que pueden deducirse de la conducta observada en el registro arqueológico. La síntesis de estos análisis nos puede aclarar, con un mayor poder explicativo, importantes aspectos sobre su diferente cultura y la definitiva desaparición del Neandertal.ABSTRACT: This current essay will analyze, in terms of cognition and cultural, the differences between two human groups that lived in Europe in the beginning of Upper Paleolithic. The aim is the understanding of the biological relationship that could have existed, as well as the cognitive capacities deduced by the behavior in the archeological register. The synthesis of this analysis shows the important aspects of their culture and the definitive disappearance of the Neanderthal beings.

  10. Programas cognitivos e passionalização do consumo nos media e na publicidade

    Directory of Open Access Journals (Sweden)

    José Luiz Aidar Prado

    2009-09-01

    Full Text Available Resumo As sociedades do capitalismo globalizado, cuja lógica cultural é o multiculturalismo (como programa de equivalência das culturas faz empuxo para a individualização. Ser um indivíduo implica pertencer a um grupo, que, por sua vez, pede ao sujeito diferenciação; por outro lado, o grupo impõe, dentro de um campo de conflitos discursivos, um empuxo pela equivalência. Coloca-se aí um jogo entre equivalências e diferenças, sem que autoridades tradicionais possam criar consensos fortes. Tal autoridade se realiza erformativamente nesse campo discursivo conflitivo. O mercado, na época da cultura dos media e da publicidade, disciplina a busca dos indivíduos a partir das tecnologias discursivas, construídas com base em uma racionalidade estratégica, bombeando as formas semânticas e pragmáticas da cultura. Trata-se, por um lado, de fornecer programas nos media, regados pelo imaginário da publicidade e do marketing, para guiar os indivíduos aos seus objetos de desejo. Por outro, é o sistema que busca tornar íntimas as buscas de dispositivos, tratamentos, substâncias, produtos, objetos carregados de atratores ao gozo de consumo. Tais programas constroem regimes de visibilidade em que certos itens são tornados positivos (euforizados e podem vir às cenas nos media com seus modos de usar e suas receitas de vida boa, enquanto outros são disforizados e relegados ao ostracismo. O empuxo ao consumo é uma forma de modalizar a busca por essa individuação privilegiada a partir de uma apresentação passionalizada de valores, ligados a marcadores culturais. Palavras-chave: Programas cognitivos dos media; capitalismo globalizado; individualização; mapas cognitivos; consumo; publicidade. Resumen Las sociedades del capitalismo globalizado, cuya lógica cultural es el multiculturalismo (como programa de equivalencia de las culturas, hacen empuje para la individualización. Ser un individuo implica pertenecer a un grupo, que, a su vez

  11. Terapias cognitivo conductuales para el tratamiento de los trastornos de personalidad

    Directory of Open Access Journals (Sweden)

    Manuela Navarro-Leis

    2013-06-01

    Full Text Available Se han propuesto muchos tratamientos psicológicos para el abordaje de los trastornos de personalidad, realizándose gran variedad de estudios para comprobar la eficacia de los mismos. Y aunque hasta la fecha no se ha podido demostrar empíricamente que exista ningún tratamiento establecido como eficaz, si se ha demostrado que los tratamientos cognitivo conductuales y conductuales resultan probablemente eficaces para el tratamiento de estos trastornos, en concreto y de forma más específica para el Trastorno Límite de Personalidad. El objetivo de este trabajo es ofrecer una revisión a nivel teórico y empírico de los tres modelos de tratamiento considerados actualmente de mayor eficacia: Terapia Dialéctica Conductual, Terapia de Aceptación y Compromiso y Psicoterapia Analítico Funcional, incluidas dentro de las llamadas Terapias de conducta de tercera generación.

  12. La solución de problemas cognitivos. Una reflexión cognitiva sociocultural

    Directory of Open Access Journals (Sweden)

    Rosalía Montealegre

    2007-06-01

    Full Text Available Este artículo, que se basa en la psicología histórico-cultural, enfatiza la solución de problemas como función psicológica superior ligada con otras funciones psíquicas: lenguaje, pensamiento, razonamiento, etc. Presenta una reflexión sociocultural sobre la solución de problemas cognitivos al abordar: 1. El pensamiento productivo (creativo: los métodos de investigación y los instrumentos (artefactos de mediación; 2. La ciencia cognitiva: el sistema de procesamiento de información, la cognición distribuida y la formación de acciones mentales; 3. El conflicto sociocognitivo: las interacciones sociales, el conflicto estructurante, la regulación sociocognitiva y la zona de desarrollo próximo. Concluye en la necesidad de formar la solución de problemas desarrollando: el pensamiento productivo, las estrategias cognitivas y el análisis de conceptos y hechos sociales

  13. Conflictos cognitivos en el Síndrome del Intestino Irritable (SII: un estudio exploratorio

    Directory of Open Access Journals (Sweden)

    Ruth Benasayag

    2004-01-01

    Full Text Available En este estudio descriptivo transversal se exploran algunas características cognitivas y sintomáticas de 13 pacientes consultantes con Síndrome del Intestino Irritable (SII comparados con una muestra de 63 sujetos no consultantes sin síntomas del SII ni psicopatológicos. El 92% de los primeros cumple criterios para algún trastorno del eje I del DSM-IV y su diagnóstico principal puede agruparse en dos categorías: trastornos por ansiedad y por somatización. En conjunto, los pacientes con SII muestran más conflictos cognitivos detectados mediante la Técnica de Rejilla (TR de Kelly que los sujetos normales. Considerando el subgrupo de trastorno por somatización, se observa una tendencia mucho más acentuada a mostrar mayor número de estos conflictos, así como una tendencia clara a presentar mayor polarización y, a su vez, menor complejidad cognitiva (diferenciación, con respecto tanto a los sujetos asintomáticos como a los diagnosticados por trastorno de ansiedad; por su parte, éstos muestran una menor autoestima.

  14. Eficacia de un tratamiento grupal cognitivo-conductual en pacientes con trastornos de ansiedad

    Directory of Open Access Journals (Sweden)

    MANUEL SÁNCHEZ GARCÍA

    2003-01-01

    Full Text Available Este estudio evalúa los datos obtenidos por 44 sujetos con diversos trastornos de ansiedad a los que se les indicó terapia grupal cognitivo-conductual. No se apreciaron diferencias significativas entre los individuos sometidos a tratamiento y el grupo control en variables sociodemográficas, estrés previo, alexitimia, estilo de afrontamiento y diagnóstico. Los resultados indican que la evolución clínica en los sujetos que asistieron a la mayoría de las sesiones es significativamente más favorable que en los sujetos-control: El seguimiento de un año muestra que son más los sujetos que reciben el alta (73.68% vs. 28% y los que ven reducida la dosis de benzodiacepinas prescrita (44.44% vs. 10.52% respecto a los controles. Entre las medidas post-tratamiento obtenidas, se hallaron disminuciones en las puntuaciones de ansiedad-estado, depresión y malestar emocional (p< .05; también mejoró, aunque con menos valor estadístico, la apreciación de su estado físico y disminuyó la frecuencia del malestar físico percibido.

  15. Mapas cognitivos na avaliação da Aprendizagem Baseada em Problemas

    Directory of Open Access Journals (Sweden)

    Adriana Casale

    2011-01-01

    Full Text Available El objetivo de este estudio es investigar el aprovechamiento de los estudiantes del curso de Ingeniería Civil en el que fue aplicado el método "Aprendizaje Basado en Problemas" (PBL como parte de innovaciones pedagógicas implementadas en una asignatura del area de Ingeniería de Transportes. Para analisar el aprovechamiento de la muestra sometida a las alternativas instruccionales fueron utilizadas las respuestas de los estudiantesa un cuestionario para evaluación del aprendizaje elaborado por el profesor. Este instrumento contribuyó para evaluar y comparar el aprendizaje de la muestra con un grupo de alumnos sometidos al modelo tradicional de enseñanza. Las respuestas fueron agrupadas y analisadas por medio de mapas cognitivos, contribuyendo con la investigación de los efectos del método PBL y de la ocurrencia de aprovechamientos diferenciados entre los alumnos. Los resultados indican que los estudiantes obtuvieron mejor envolvimiento, desarrollos de comportamientos y actitudes, compromiso con el propio aprendizaje y un aprovechamiento significativamente mejor con el nuevo diseño de la asignatura.

  16. Prevalencia del deterioro cognitivo leve en mayores institucionalizados Prevalencia of the mild cognitive impairment in institutionalized elders

    Directory of Open Access Journals (Sweden)

    Jesús Manuel Vallejo Sánchez

    2010-12-01

    Full Text Available Introducción y objetivo: el concepto de deterioro cognitivo leve (DCL define un estado previo en el declinar cognitivo hacia la demencia, donde se observan cambios cognitivos identificables mediante una adecuada evaluación clínica y neuropsicológica. Nuestro objetivo es conocer la prevalencia del deterioro cognitivo leve en la Residencia José Matía Calvo. Método: estudio observacional descriptivo transversal de los residentes institucionalizados con ausencia de patología neurológica o deterioro cognitivo severo de la Residencia de Mayores José Matía Calvo de Cádiz. Se cribó a los sujetos con el mini examen cognoscitivo en la versión de Lobo durante enero de 2008, obteniéndose una muestra de la que se estudiaron variables sociodemográficas y de control (estado cognitivo. Resultados: se desprende que la prevalencia de DCL en los ancianos institucionalizados en nuestro centro es del 27%, cifra más elevada que la aportada como media por algunos autores para la población general (15%-20%, pero menor que la establecida en otras residencias de mayores, que oscilan entre el 38,7% y el 44%. Conclusiones: el aumento constatado de la prevalencia del deterioro cognitivo en la población mayor y su repercusión en el nivel de independencia y calidad de vida de los mayores institucionalizados justifica la necesidad de identificar precozmente tal alteración para iniciar, lo antes posible, programas de intervención dirigidos a retrasar la dependencia, potenciar las capacidades residuales y mejorar la calidad de vida de estos ancianos.Introduction and objetive: the concept of Mild cognitive impairment defines a previous state in to decline cognitive towards the dementia, where are observed cognitive identifiable changes by means of a suitable clinical and evaluation and neuropsycological. To know the prevalencia of the cognitive slight deterioration in our center. Methods: observacional, descriptively and transversely study of the residents

  17. Los sistemas cognitivos artificiales en la enseñanza de la matemática Os sistemas cognitivos artificiais no ensino da matemática Artificial Cognitive Systems in Teaching Mathematics

    Directory of Open Access Journals (Sweden)

    Luis Alberto Toro-Carvajal

    2012-08-01

    Full Text Available Este artículo presenta la implementación de los sistemas cognitivos artificiales (SCA en los procesos de enseñanza-aprendizaje de las matemáticas. La justificación teórica de tal implementación se hace desde el punto de vista de la Matemática y la Educación Matemática como ciencias y la Ciencia Cognitiva, de las cuales emerge el Modelo Computacional-Representacional de la Matemática (MCRMAT. Este modelo de las matemáticas da cuenta del porqué los procesos de enseñanza-aprendizaje de las matemáticas pueden y deben ser mediados mediante los sistemas cognitivos artificiales, que deben ser entendidos como herramientas de reorganización cognitiva. La comprensión que se alcance sobre el conocimiento producido con la mediación de las herramientas proporcionadas por los sistemas cognitivos artificiales es importante para la enseñanza de la matemática. En los ejemplos que se presentan en este trabajo se ha empleado software licenciado como Matlab y Mathcad.Este artigo apresenta a implementação dos sistemas cognitivos artificiais (SCA nos processos de ensino-aprendizagem da matemática. A justificativa teórica dessa implementação se faz sob o ponto de vista da Matemática e da Educação Matemática como ciências e a Ciência Cognitiva, das quais emerge o Modelo Computacional-Representacional da Matemática (MCRMAT. Esse modelo da matemática dá conta de por que os processos de ensino-aprendizagem da matemática podem e devem ser mediados pelos sistemas cognitivos artificiais, que devem ser entendidos como ferramentas de reorganização cognitiva. A compreensão que se atinge sobre o conhecimento produzido com a mediação das ferramentas proporcionadas pelos sistemas cognitivos artificiais é importante para o ensino da matemática. Nos exemplos que se apresentam neste trabalho, empregou-se o software licenciado como Matlab e Mathcad.The use of artificial cognitive systems (ACS in processes for teaching-learning mathematics is

  18. Terapia cognitivo-comportamental para luto pela morte súbita de cônjuge

    Directory of Open Access Journals (Sweden)

    Adriana Cardoso de Oliveira e Silva

    2011-01-01

    Full Text Available INTRODUÇÃO: O processo de luto devido à morte súbita de cônjuge apresenta particularidades que devem ser consideradas no atendimento clínico daqueles que passam por essa experiência. MÉTODOS: Estudo de caso de terapia para luto utilizando protocolo de atendimento cognitivista comportamental. O progresso da paciente foi avaliado no início e término do tratamento com Inventário Beck de Depressão (BDI, Inventário Beck de Ansiedade (BAI e Escala Beck de Desesperança (BHS, Inventário de Sintomas de Stress de Lipp (ISSL e Questionário de Saúde Geral (QSG. RESULTADOS: Houve redução da depressão, ansiedade e desesperança. Em relação ao estresse, a paciente passou da fase de exaustão para a de resistência. Houve redução do estresse psíquico (de 95% para 50%, da desconfiança em relação ao próprio desempenho (de 90% para 40%, de distúrbios do sono (de 95% para 45%, de desejo de morte (de 95% para 20% e também de distúrbios psicossomáticos (de 95% para 60%. CONCLUSÃO: O atendimento terapêutico para esse tipo específico de luto mediante o enfoque da terapia cognitivo-comportamental se mostrou eficaz.

  19. Deterioro cognitivo leve: ¿dónde termina el envejecimiento normal y empieza la demencia?

    Directory of Open Access Journals (Sweden)

    Nilton Custodio

    2012-10-01

    Full Text Available Con el aumento de la prevalencia de demencia en el mundo, debemos poner especial atención a la evaluación diagnóstica de estadios previos a la demencia. El deterioro cognitivo leve (DCL podría ser considerado un estadio precoz de demencia, en especial de la enfermedad de Alzheimer (AD; por lo que consideramos importante un diagnóstico adecuado, mediante la utilización de instrumentos y técnicas fiables y sensibles, que permitan discriminar entre sujetos con envejecimiento normal y patológico. Los estudios epidemiológicos muestran una elevada prevalencia de DCL en la población general. Asimismo, se ha documentado la progresión de DCL a demencia y EA, sobre todo en sujetos con DCL del tipo amnésico. La edad, el estado de portador del APOE-ε4, la atrofia del hipocampo en resonancia magnética y la presencia de algunos biomarcadores en líquido cefalorraquídeo parecen influir en la conversión. Se sugiere que el estudio de pacientes con sospecha de DCL sea el mismo que se emplea en la sospecha de demencia y EA. La evaluación neuropsicológica es la única prueba que permite confirmar el diagnóstico y nos ayuda a realizar una adecuada clasificación de los subtipos de DCL: amnésico, multidominio y monodominio no amnésico.

  20. Introducción: Una apuesta por pensar desde la tesis del Capitalismo Cognitivo

    Directory of Open Access Journals (Sweden)

    Gabriel Giannone

    2016-12-01

    Full Text Available Una creciente difusión del conocimiento y la incorporación de nuevas tecnologías de la información y la comunicación en los procesos productivos durante las últimas décadas −tanto en el tiempo de trabajo así como en el de no trabajo− presentan una evidencia clara sobre la importancia del conocimiento y la subsunción del trabajo inmaterial en la valorización del capital. Desde la masificación de la conexión en red –y la segunda y tercera generación de internet− se produjo una ascendente curva en esa evidencia, a partir de la apreciación del registro de datos masivos de la experiencia humana. La certeza de atravesar un modelo de producción transfigurado por la economía intangible ha dado espacio para definiciones tales como las de Sociedad de la Información, Sociedad del Conocimiento o Economía basada en el conocimiento. La apuesta de estudio presentada por la Revista Chasqui para el Monográfico de su edición Nº133, así como el cuerpo de investigaciones que forman parte de esta colección, pueden definirse a partir de una desconfianza a estas posturas asépticas planteadas por las teorías liberales. La impugnación del carácter poco conflictivo de estas apreciaciones permite abonar la hipótesis de encontrarnos en un momento donde ha madurado una modificación al modelo de desarrollo fordista, en favor de un modelo de capitalismo cognitivo.

  1. Crisis de la valoración contable en el capitalismo cognitivo

    Directory of Open Access Journals (Sweden)

    Pablo Archel Domench

    2014-02-01

    Full Text Available El declive del fordismo como modo mayoritario de regulación de la producción económica está dando paso a otros modelos en los que el trabajo inmaterial aparece como una de las principales fuentes de creación del valor. En este contexto, la medición fiable del valor y del resultado empresarial constituye uno de los mayores retos a los que se enfrenta la comunidad contable. La adopción internacional del modelo contable del IASB, con la hegemonía del valor razonable como criterio preferente de valoración, se interpreta como un paso más en la búsqueda de expropiación y privatización del valor producido por el trabajo inmaterial y que correspondería al común. A partir de las construcciones teóricas desarrolladas por Lazzarato y Negri (1997 y Hardt y Negri (2000 y 2004, este trabajo identifica dos tipos de causas (externas e internas a la contabilidad que explican las dificultades en la medición del valor generado por el trabajo inmaterial en la época del capitalismo cognitivo. Por ello, los criterios convencionales de valoración contable (coste histórico y valor razonable, surgidos previamente en la evolución histórica del capitalismo, resultan inadecuados para captar y representar el valor de la producción inmaterial.

  2. Grupoterapia cognitivo-comportamental para crianças e adolescentes vítimas de abuso sexual

    OpenAIRE

    Habigzang,Luísa Fernanda; Stroeher,Fernanda Helena; Hatzenberger,Roberta; Cunha,Rafaela Cassol; Ramos,Michele da Silva; Koller,Sílvia Helena

    2009-01-01

    OBJETIVO: Avaliar os efeitos do modelo de grupoterapia cognitivo-comportamental para crianças e adolescentes do sexo feminino vítimas de abuso sexual. MÉTODOS: Foi utilizado delineamento não-randomizado intragrupos de séries temporais. Crianças e adolescentes do sexo feminino com idade entre nove e 16 anos (N=40) da região metropolitana de Porto Alegre (RS), foram clinicamente avaliadas em três encontros individuais, de 2006 a 2008. A grupoterapia consistiu de 16 sessões semi-estruturadas. In...

  3. Eficacia de la terapia cognitivo conductual (TCC) y de la TCC-focalizada en el trauma en infancia maltratada

    OpenAIRE

    Prieto Larrocha, Macarena

    2016-01-01

    Objetivo: El propósito fundamental del presente trabajo fue proporcionar evidencia empírica acerca de la eficacia del modelo de Terapia Cognitivo Conductual (TCC) en general, y del modelo de TCC-Focalizada en el Trauma (TCC-FT) en particular, para el tratamiento del estrés postraumático, la sintomatología depresiva y los problemas del comportamiento, en niños y adolescentes víctimas de maltrato intrafamiliar crónico en situación de acogimiento residencial o familiar. Para ello, se llevó a cab...

  4. Estudio cognitivo sobre el contenido de conceptos (científicos, concretos y abstractos) y la influencia del conocimiento

    OpenAIRE

    Geral Eduardo Mateus Ferro

    2014-01-01

    Este artículo tiene como objetivo hacer un estudio cognitivo sobre el contenido de conceptos científicos, concretos y abstractos en 139 participantes distribuidos en tres grupos con distinto conocimiento en ciencias (alto, medio y bajo). La metodología se centra en la realización de tareas de generación de propiedades y el posterior análisis de los protocolos de respuesta según el modelo planteado por Wu y Barsalou (2009). Se analiza si las diferencias de conocimiento entre los grupos de part...

  5. Estudio cognitivo sobre el contenido de conceptos (científicos, concretos y abstractos) y la influencia del conocimiento

    OpenAIRE

    Mateus Ferro, Geral Eduardo

    2014-01-01

    Este artículo tiene como objetivo hacer un estudio cognitivo sobre el contenido de conceptos científicos, concretos y abstractos en 139 participantes distribuidos en tres grupos con distinto conocimiento en ciencias (alto, medio y bajo). La metodología se centra en la realización de tareas de generación de propiedades y el posterior análisis de los protocolos de respuesta según el modelo planteado por Wu y Barsalou (2009). Se analiza si las diferencias de conocimiento entre los grupos de part...

  6. Programa de entrenamiento cognitivo-constructivista para piano de acompa??amiento de ballet cl??sico

    OpenAIRE

    Herrera Torres, Luc??a; G??mez, Ileana Guillermina

    2011-01-01

    El aprendizaje del piano de acompa??amiento es una tarea compleja para la que se requiere m??ltiples habilidades. Entre ellas, dos son de especial relevancia: el control r??tmico y el procesamiento dual. El presente trabajo tiene como objetivo principal analizar la eficacia de un programa de entrenamiento cognitivo-constructivista en el piano de acompa??amiento de ballet cl??sico. Para ello, se realiz?? un estudio de casos con tres alumnos de la materia Pr??cticas de acompa??am...

  7. Estudio prospectivo del funcionamiento cognitivo en pacientes de cáncer de colon tratados con quimioterapia

    OpenAIRE

    López Santiago, Sonia

    2012-01-01

    El objetivo de esta tesis es investigar los cambios en rendimiento cognitivo de pacientes de cáncer de colon tratados con quimioterapia adyuvante. El método ha sido el estudio longitudinal unifactorial de tres medidas (T1: antes de la quimioterapia, T2: al finalizar el tratamiento y T3 seis meses después de T2); se explora: memoria verbal, función ejecutiva y habilidad psicomotora y variables moduladoras (ansiedad, depresión, astenia y calidad de vida). Muestra: 77 participantes, 63% varones,...

  8. Estudio neuropsicológico del deterioro cognitivo ligero en la lesión medular espinal

    OpenAIRE

    Molina Gallego, Brígida

    2016-01-01

    Esta investigación ha tenido como objetivo evaluar la función cognitiva en los pacientes lesionados medulares espinales, teniendo en cuenta el tiempo de evolución desde su lesión. Para ello se investigó la existencia de diferencias en cuanto al rendimiento cognitivo se refiere, en pacientes con lesión medular aguda en relación con los pacientes con lesión medular crónica. La muestra estuvo formada por 100 pacientes que habían sufrido una lesión medular, concretamente la evaluación se real...

  9. Habilidades adaptativas y estilos cognitivos de niños y niñas diagnosticados con TDAH

    OpenAIRE

    Millán Restrepo, Doris

    2014-01-01

    Artículo (Maestría en Desarrollo Infantil). Universidad de Manizales. Facultad de Ciencias Sociales y Humanas, 2014 El presente estudio se llevó a cabo con el propósito de establecer la relación entre los estilos cognitivos en la dimensión reflexividad- impulsividad (r/i) y las habilidades adaptativas. La muestra de estudio estuvo conformada por 38 niños y niñas con TDAH con edades comprendidas entre los 8 y 10 años de edad de una institución educativa de carácter privado de la ciudad de P...

  10. ¿Capitalismo y urbanización en una nueva Clave? la dimensión Cognitivo-Cultural

    Directory of Open Access Journals (Sweden)

    Allen J. Scott

    2007-01-01

    Full Text Available Las dimensiones cognitivo-culturales del capitalismo contemporáneo se identifican haciendo referencia a sus sectores dominantes, tecnologías básicas, sistemas de relaciones laborales y estructuras de mercado. los sistemas cognitivo-culturales de producción y trabajo se manifiestan predominantemente en grandes ciudades-regiones. Tal estado de cosas se manifiesta en los diversos agrupamientos de sectores de tecnología avanzada, funciones de servicios, actividades manufactureras neoartesanales y productos culturales que suelen encontrarse en estas regiones. También se manifiesta en la formación de una amplia capa de empleados cognitivo-culturales altamente calificados, en las áreas urbanas. Muchos de ellos se ocupan en formas características de aprendizaje en el trabajo, de creatividad y de innovación. Al mismo tiempo, la economía cognitivo-cultural en las ciudades contemporáneas se complementa invariablemente con grandes cantidades de trabajos con bajos requerimientos de capacitación y bajos salarios, y los individuos que se enrolan en ellos son por lo general inmigrantes de países en desarrollo. Las ramifi- caciones ideológico-políticas de esta situación son materia de análisis en el contexto de una crítica de la actual idea muy en boga de la «ciudad creativa». Aventuro la hipótesis de que debemos ir más allá de defensas del desarrollo económico local que prescriban el despliegue de paquetes de comodidades selectas como una manera de atraer a trabajadores elites a ciertas áreas urbanas. en lugar de ello, propongo que los formuladores de políticas presten mayor atención a la dinámica del sistema de producción cognitivocultural como tal, y que en el interés de dar forma a comunidades urbanas viables en el capitalismo moderno seamos más firmes en los intentos por reconstruir la sociabilidad, la solidaridad y la participación democrática.

  11. Qualidade de vida, funcionamento cognitivo e adesão em idosos : um estudo exploratório

    OpenAIRE

    Gonçalves, Daniela Patrícia Araújo

    2012-01-01

    Tese de mestrado, Psicologia (Secção de Psicologia Clínica e Saúde - Núcleo de Psicologia da Saúde e da Doença), Universidade de Lisboa, Faculdade de Psicologia, 2012 O processo de envelhecimento acarreta inúmeras mudanças para o idoso. Devido às alterações físicas, psicológicas e sociais que se dão nessa fase de vida, o estado emocional, o funcionamento cognitivo e a capacidade funcional do idoso podem alterar-se, havendo por vezes uma maior preponderância de sentimentos menos positivos. ...

  12. O controle da raiva: eficácia do treino cognitivo na doença arterial coronariana

    OpenAIRE

    Lipp,Marilda Emmanuel Novaes; Pinho,Cláudio; Casteli,Ana Carolina; Santos,Micheli Gomes dos; Fujita,Angela Tamey

    2009-01-01

    Este estudo teve por objetivos averiguar se o treino cognitivo de controle da raiva é eficaz na redução da reatividade cardiovascular de pacientes diagnosticados com doença arterial coronariana, avaliar seu impacto na redução da raiva e no nível de stress e analisar se há correlação significativa entre a raiva e a magnitude na reatividade cardiovascular em momentos de stress experimental. Vinte e nove adultos com doença arterial coronariana participaram da pesquisa. A reatividade cardiovascul...

  13. Educación y funcionamiento cognitivo en mayores: aplicaciones del concepto de zona de desarrollo próximo

    OpenAIRE

    Calero García, María Dolores

    2001-01-01

    La visión del funcionamiento cognitivo en el anciano ha consistido tradicionalmente en la consideración de un declive progresivo centrado en algunas áreas de razonamiento. Hace pocos años que algunos autores defienden la hipótesis del desuso como hipótesis explicativa de este declive y a esta aparece ligado el constructo "plasticidad". La presencia de plasticidad en las personas mayores ha sido demostrado en multitud de trabajos, lo que ha contribuido a analizar el papel preventivo y terapéut...

  14. Treinamento físico intervalado como ferramenta na terapia cognitivo-comportamental do transtorno de pânico

    Directory of Open Access Journals (Sweden)

    Aline Sardinha

    2011-01-01

    Full Text Available Este trabalho consiste no relato da utilização de um programa de exercícios físicos aeró-bicos intervalados no contexto da terapia cognitivo-comportamental em um caso de transtorno de pânico e agorafobia. São descritos os procedimentos utilizados, bem como os resultados positivos obtidos na redução da ansiedade cardíaca e na ansiedade cotidiana em relação a situações que exigem esforço físico.

  15. Treinamento físico intervalado como ferramenta na terapia cognitivo-comportamental do transtorno de pânico

    OpenAIRE

    Sardinha,Aline; Araújo,Claudio Gil Soares de; Nardi,Antonio Egidio

    2011-01-01

    Este trabalho consiste no relato da utilização de um programa de exercícios físicos aeró-bicos intervalados no contexto da terapia cognitivo-comportamental em um caso de transtorno de pânico e agorafobia. São descritos os procedimentos utilizados, bem como os resultados positivos obtidos na redução da ansiedade cardíaca e na ansiedade cotidiana em relação a situações que exigem esforço físico.

  16. Treinamento físico intervalado como ferramenta na terapia cognitivo-comportamental do transtorno de pânico

    OpenAIRE

    Sardinha, Aline; Araújo, Claudio Gil Soares de; Nardi, Antonio Egidio

    2011-01-01

    Este trabalho consiste no relato da utilização de um programa de exercícios físicos aeró-bicos intervalados no contexto da terapia cognitivo-comportamental em um caso de transtorno de pânico e agorafobia. São descritos os procedimentos utilizados, bem como os resultados positivos obtidos na redução da ansiedade cardíaca e na ansiedade cotidiana em relação a situações que exigem esforço físico. The present article reports the use of an interval aerobic exercise program as an adjunct interve...

  17. Deterioro cognitivo y horas de sueño en mayores de 65 años no institucionalizados: estudio en farmacia comunitaria

    Directory of Open Access Journals (Sweden)

    Climent MT

    2015-06-01

    Full Text Available Objetivo: Determinar factores de riesgo, relacionados con el estilo de vida, asociados con la presencia de deterioro cognitivo en personas mayores de 65 años. Método: Para ello se diseñó un estudio observacional transversal con personas mayores de 65 años no institucionalizadas mediante entrevista personal estructurada. El estudio se realizó en 14 farmacias de la Comunidad Valenciana desde marzo 2011 hasta marzo de 2013. Se utilizan como test de cribado el Short Portable Mental State Questionnaire (SPMSQ de Pfeiffer y el Mini-Mental State Examination (MMSE versión NORMACODERM de Blesa. Se definió deterioro cognitivo por SPMSQ ≥ 3 (para analfabetos ≥ 4 y/o MMSE ≤ 24. Resultados: Participaron en el estudio 729 personas. Se encontró que el 17,6% de los participantes (n = 128 presentaban resultados compatibles con deterioro cognitivo. Se determinó que dormir 9 o más horas diarias es causa o consecuencia y, por tanto, un factor de riesgo y/o de alarma en el desarrollo de deterioro cognitivo en personas mayores de 65 años. El ejercicio físico y pocas horas de sueño no obtuvo relación con el deterioro cognitivo. Conclusión: El cambio de hábitos de sueño en el anciano (pasar a dormir más horas es una señal de alerta para estudiar la presencia de un posible deterioro cognitivo.

  18. OCUPACIÓN LABORAL Y RIESGO DE DETERIORO COGNITIVO Y DEMENCIA EN PERSONAS MAYORES DE 55 AÑOS: UNA REVISIÓN SISTEMÁTICA

    Directory of Open Access Journals (Sweden)

    Ana Cristina Gracia Rebled

    2016-01-01

    Full Text Available Fundamentos: El deterioro cognitivo y la demencia son dos problemas de salud con elevada prevalencia en población mayor. Es importante identificar los factores de riesgo potencialmente modificables asociados. La ocupación laboral podría ser un factor que influye en la demencia. El objetivo fue analizar la asociación entre la ocupación principal desarrollada a lo largo de la vida con el deterioro cognitivo y la demencia en personas mayores. Métodos: Revisión sistemática de la literatura desde 1990 y marzo de 2014 para identificar la asociación entre ocupación y deterioro cognitivo evaluado por el Mini Mental Status Examination (MMSE. La búsqueda se realizó en las bases de datos Web of Knowledge, Pubmed, Medline, ISI Web of Science, Science Direct, CocINDEX with Full Text, SPORTDiscus with Full Text, Dialnet Plus, Education Resources Information Center, GreenFile, Journal Storage y The Cochrane Library. Criterios de inclusión: artículos publicados entre 1990 y marzo de 2014 que utilizaran el MMSE para valorar el rendimiento cognitivo en población mayor de 55 años y que incluyeran la ocupación como variable de estudio así como la existencia de deterioro cognitivo o demencia, escritos en castellano, inglés o francés. Resultados: Se seleccionaron 18 artículos. Cinco estudios transversales y seis longitudinales analizaron la asociación entre ocupación y deterioro cognitivo; dos transversales y ocho longitudinales estudiaron la asociación entre demencia y ocupación. El 67% identificaron que había relación entre el tipo de trabajo y el rendimiento cognitivo en la edad adulta. Conclusiones: Las personas con una actividad laboral predominantemente manual a lo largo de la vida tienen mayor riesgo de padecer deterioro cognitivo y/o demencia que aquellas que tienen ocupaciones con mayor requerimiento intelectual.

  19. Perfil cognitivo en pacientes con infección por el virus de inmunodeficiencia humana neurológicamente asintomáticos

    OpenAIRE

    Erik Guevara-Silva

    2013-01-01

    Introducción: Diversos estudios han comunicado la presencia de deterioro cognitivo asociado al virus de inmunodeficiencia humana (VIH) tipo 1, aún en estadios tempranos de la infección. Las principales funciones comprometidas son la memoria a corto plazo, velocidad psicomotriz, atención y función ejecutiva. Objetivos: Describir el perfil cognitivo en pacientes con VIH neurológicamente asintomáticos, antes de iniciar terapia antirretroviral de gran actividad (TARGA), y determinar posibles fact...

  20. Combinación entre Algoritmos Genéticos y Aleatorios para la Programación de Horarios de Clases basado en Ritmos Cognitivos

    OpenAIRE

    Castrillón, Omar D

    2014-01-01

    Se ha diseñado un método basado en algoritmos evolutivos (genéticos y aleatorios) para programar los horarios de clases en una universidad. Esta metodología considera los ritmos cognitivos de los estudiantes que indican que es mejor enseñar algunas asignaturas en intervalos específicos de tiempo. Primero se describen las diferentes técnicas empleadas para desarrollar este problema. Luego se propone una nueva metodología basada en ritmos cognitivos y algoritmos evolutivos, para resolver todas ...

  1. Potencial evocado miogênico vestibular ocular: revisão de literatura

    OpenAIRE

    Silva,Tatiana Rocha; Resende,Luciana Macedo de; Santos,Marco Aurélio Rocha

    2016-01-01

    RESUMO Objetivo Identificar e sistematizar os principais estudos sobre o potencial evocado miogênico vestibular ocular e suas aplicações no diagnóstico das diversas doenças vestibulares. Estratégia de pesquisa Foram localizados artigos que descrevem a utilização do potencial evocado miogênico vestibular ocular na avaliação de doenças vestibulares nas bases PubMed, Web of Science, MEDLINE, Scopus, LILACS e SciELO. Critérios de seleção Foram incluídos estudos originais, com resumo disponí...

  2. ANÁLISE DA IMPLEMENTAÇÃO DE ESTRATÉGIA EM EMPRESA HOSPITALAR COM USO DE MAPAS COGNITIVOS

    Directory of Open Access Journals (Sweden)

    Fernanda de Menezes Guimarães

    2009-10-01

    Full Text Available Este artigo analisa os fatores de influência na implementação de uma estratégia no ambiente hospitalar.Tal estratégia é a implementação do Time de Resposta Rápida em unidades de internação, buscandoqualidade e segurança na assistência ao paciente hospitalizado. A escolha baseou-se em analisar umaestratégia que tivesse gerado resultados positivos para a instituição em estudo. O trabalho utilizou-se depesquisa qualitativa de caráter exploratório, sendo um Estudo de Caso único, realizado em um hospitalprivado de Porto Alegre (RS. Foram realizadas entrevistas em profundidade e também foram aplicadosMapas Cognitivos Causais. Como resultados da pesquisa, o fator diferencial identificado que determinouo sucesso da implementação do Time de Resposta Rápida foi o componente humano. Tal processoem estudo também teve êxito pela congregação de múltiplos fatores que se tornaram facilitadores paragarantir esse sucesso. Como contribuição acadêmica, o Mapeamento Cognitivo traz uma possibilidadepara compreender-se melhor o pensamento dos níveis hierárquicos no processo da estratégia.

  3. ALTAS HABILIDADES/SUPERDOTAÇÃO: um olhar para o desenvolvimento cognitivo, ajuste emocional e seus impactos na vida profissional

    Directory of Open Access Journals (Sweden)

    Alberto Padrón Abad

    2016-12-01

    El objetivo del presente artículo es analizar los factores de desarrollo cognitivo, ajuste emocional del individuo AH/SD y sus impactos en la vida profesional y laboral. La metodología empleada está basada en una investigación bibliográfica, exploratoria y descriptiva realizada a partir de referencias teóricas, referentes al tema, previamente analizadas y publicadas. En este sentido, se iniciará considerando los factores que facilitan el ajuste emocional de individuos AH/SD (familiares, escolares, laborales e interpersonales. Posteriormente, se analizará la pregunta: ¿por qué existen personas que a pesar de vivir en situaciones sociales y económicas desfavorables pueden desarrollar sus AH/SD y ser profesionales de éxito, mientras otros, con todas las oportunidades en la vida no llegan al éxito profesional ni contribuyen efectivamente con la sociedad? Con la intención de responder esa pregunta se estudiarán: el concepto de resiliencia, la Teoría de la Evaluación Cognitiva de Lazarus y la Teoría de la Desintegración Positiva de Dabrowski. De esta manera, se concluye la importancia de aplicar de manera efectiva los modelos teóricos ya propuestos, de modo comprensivo y explicativo, de las AH/SD acerca de los aspectos del desarrollo cognitivo y emocional de los individuos.

  4. Las nuevas tecnologías en la terapia cognitivo-conductual: una revisión

    Directory of Open Access Journals (Sweden)

    Xavier Bornas

    2002-01-01

    Full Text Available En este trabajo se hace un análisis del uso de las nuevas tecnologías como elemento terapéutico en el campo de la psicología cognitivo-conductual. Tras seleccionar las palabras-clave se realizó una búsqueda en las bases de datos Eric, PsycInfo, Dissertations Abstracts Online, Scy Search, Sociological Abstracts y Pascal a partir de 1990. La revisión de los trabajos publicados proporcionó información sobre tecnología usada, trastorno específico, muestra y diseño, descripción del funcionamiento y resultados. El ordenador aparece como la tecnología más empleada y los trastornos de ansiedad son los que han recibido más atención mediante nuevas tecnologías. La realidad virtual e internet son más usadas a partir de 1995. La eficacia de los tratamientos es elevada y comparable a la de los más tradicionales. Aunque los resultados indican un creciente uso de las nuevas tecnologías en la terapia cognitivo-conductual, esto es más cierto en los ámbitos académicos que en los clínicos. Estos aspectos se tratan en la discusión

  5. Confiabilidade do Teste WPPSI-R na avaliação do desenvolvimento cognitivo de pré-escolares

    Directory of Open Access Journals (Sweden)

    Maria Dalva Barbosa Baker Méio

    Full Text Available O Teste psicométrico WPPSI-R (Wechsler Preschool and Primary Scale of Intelligence - Revised foi o instrumento de avaliação em uma pesquisa para estudar o desenvolvimento cognitivo, na idade pré-escolar, de uma população de crianças do Instituto Fernandes Figueira (IFF nascidas prematuras e de muito baixo peso (MBP, aplicado por quatro psicólogas previamente treinadas. O objetivo deste estudo foi avaliar a confiabilidade inter-observador na aplicação do teste. Utilizaram-se dois desenhos: de blocos incompletos equilibrados, para avaliar a concordância na aplicação do teste, e cruzado, para avaliar a concordância na pontuação dos itens. Foram estudadas 12 crianças pré-escolares nascidas no IFF (Peso ao nascer < 1.500g. Os coeficientes de correlação intraclasse (CCI encontrados foram: 0,82 (Escore Total, 0,89 (Escore Verbal e 0,91 (Escore Executivo, no desenho de blocos incompletos equilibrados, e 0,99, 0,98 e 0,99, respectivamente, no desenho cruzado, indicando uma boa confiabilidade. Estes achados mostram que a aplicação do Teste WPPSI-R no estudo do desenvolvimento cognitivo de prematuros de MBP do IFF foi adequada.

  6. LA ENTREVISTA FORENSE: OBTENCIÓN DEL INDICIO COGNITIVO EN MENORES PRESUNTAS VÍCTIMAS DE ABUSO SEXUAL INFANTIL

    Directory of Open Access Journals (Sweden)

    José M. Muñoz

    2016-05-01

    Full Text Available Las características que rodean a los delitos de abuso sexual infantil (ASI, puesto que muchos se cometen en la clandestinidad, sin testigos y sin evidencias físicas que los corroboren, dificultan el enjuiciamiento de los mismos. El análisis y valoración del indicio cognitivo (huella de memoria se convierte así en el principal medio de prueba con el que cuenta el juez. La entrevista forense es el instrumento mediante el cual el perito psicólogo obtiene este indicio cognitivo para su posterior análisis y valoración en términos de credibilidad. En el presente artículo se alerta sobre los posibles sesgos en el entrevistador y errores procedimentales que pueden contaminar la obtención del relato del menor, y se propone un diseño del proceso de entrevista forense con el objetivo de facilitar la labor pericial y minimizar esos posibles sesgos. Se hace hincapié en la necesidad de que el evaluador cuente con formación y entrenamiento especializado en esta técnica.

  7. A nova divisão internacional do trabalho, capitalismo cognitivo e desenvolvimento na América Latina

    Directory of Open Access Journals (Sweden)

    Carlo Vercellone

    2016-12-01

    Full Text Available O artigo propõe revisar questões relacionadas ao desenvolvimento da América Latina em função das transformações inerentes à crise do capitalismo industrial e à transição a um ‘novo capitalismo’, categorizado como capitalismo cognitivo. Com este objetivo, a análise está dividida em três partes. Na primeira parte se propõe uma revisão da crise estrutural do paradigma da industrialização, legado das teorias do desenvolvimento formuladas entre os anos 1950-1980. A segunda parte aborda as dificuldades e desafios produzidos pela nova divisão internacional do trabalho, fundada sobre os princípios cognitivos e o fortalecimento dos direitos de propriedade intelectual. E, finalmente uma terceira parte na qual se busca identificar certas características de uma estratégia de desenvolvimento pós-industrial para os países latino-americanos.

  8. O valor no capitalismo cognitivo e a cultura hacker | Value in cognitive capitalism and the hacker culture

    Directory of Open Access Journals (Sweden)

    Fabio Malini Lima

    2009-09-01

    Full Text Available Resumo Este trabalho busca organizar os principais debates sobre o conceito de valor no interior da crítica ao capitalismo cognitivo, sobretudo na obra de Antonio Negri e André Gorz. Parte-se dessa crítica para se chegar à análise da cultura hacker como um novo campo de antagonismo social, marcado pela renovação do conceito de resistência, onde a valorização da mercadoria se associa cada vez mais ao aumento da quantidade de cooperação social e inteligência incorporadas aos bens/serviços, sem que necessariamente passe por processos de exploração capitalista. Palavras-chave capitalismo cognitivo; valor; conhecimento; informação Abstract This study attempts to organize the main debates about the concept of value within the critique of cognitive capitalism, especially in the work of Antonio Negri and André Gorz. It is of critical analysis to reach the hacker culture as a new field of social tension, marked by the renewal of the concept of resistance, where the recovery of the goods is even more associated to the increased amount of cooperation and social intelligence embedded in products/services, without necessarily passing through processes of capitalist exploitation.  Keywords cognitive capitalism; value; knowledge; information

  9. Confiabilidade do Teste WPPSI-R na avaliação do desenvolvimento cognitivo de pré-escolares

    Directory of Open Access Journals (Sweden)

    Méio Maria Dalva Barbosa Baker

    2001-01-01

    Full Text Available O Teste psicométrico WPPSI-R (Wechsler Preschool and Primary Scale of Intelligence - Revised foi o instrumento de avaliação em uma pesquisa para estudar o desenvolvimento cognitivo, na idade pré-escolar, de uma população de crianças do Instituto Fernandes Figueira (IFF nascidas prematuras e de muito baixo peso (MBP, aplicado por quatro psicólogas previamente treinadas. O objetivo deste estudo foi avaliar a confiabilidade inter-observador na aplicação do teste. Utilizaram-se dois desenhos: de blocos incompletos equilibrados, para avaliar a concordância na aplicação do teste, e cruzado, para avaliar a concordância na pontuação dos itens. Foram estudadas 12 crianças pré-escolares nascidas no IFF (Peso ao nascer < 1.500g. Os coeficientes de correlação intraclasse (CCI encontrados foram: 0,82 (Escore Total, 0,89 (Escore Verbal e 0,91 (Escore Executivo, no desenho de blocos incompletos equilibrados, e 0,99, 0,98 e 0,99, respectivamente, no desenho cruzado, indicando uma boa confiabilidade. Estes achados mostram que a aplicação do Teste WPPSI-R no estudo do desenvolvimento cognitivo de prematuros de MBP do IFF foi adequada.

  10. El nivel de vocabulario como indicador de reserva cognitiva en la evaluación del deterioro cognitivo ligero

    Directory of Open Access Journals (Sweden)

    Cristina Lojo-Seoane

    2014-10-01

    Full Text Available El presente trabajo estudia el papel del vocabulario, como indicador de reserva cognitiva, en la evaluación del Deterioro Cognitivo Ligero (DCL. Participaron 326 adultos mayores de 50 años, clasificados en dos grupos, uno de 104 participantes con DCL y otro de 222 controles sanos. Se analizaron las diferencias en las puntuaciones obtenidas en distintos indicadores de reserva cognitiva, entre ellos, las puntuaciones en el subtest de vocabulario WAIS y la prueba de vocabulario de imágenes Peabody. Para analizar el efecto de estos indicadores en la prevalencia del DCL se llevó a cabo un análisis de regresión logística. Los resultados indicaron que el grupo con DCL obtuvo puntuaciones significativamente menores que los controles en las tareas de vocabulario y en los hábitos de lectura. Las bajas puntuaciones en las pruebas de vocabulario fueron las medidas de reserva cognitiva que mejor predicen el riesgo de DCL. Teniendo en cuenta los resultados, el buen nivel de vocabulario parece contribuir a aumentar la reserva cognitiva como un indicador protector frente al deterioro cognitivo.

  11. Papel da informação na área da qualidade: do fordismo ao capitalismo cognitivo

    Directory of Open Access Journals (Sweden)

    Vanessa de Arruda JORGE

    Full Text Available Este artigo objetiva analisar o papel da informação nas principais mudanças ocorridas na área da qualidade, de modo associado às transformações no trabalho. Com base em pesquisa e análise bibliográfica, desenvolveu-se um quadro analítico, em que se apresenta uma periodização dando conta da evolução das mudanças da informação, ao longo das diferentes fases históricas da qualidade, em sua relação com as transformações no trabalho, desde o fordismo até o capitalismo cognitivo. Conclui-se que a informação ganhou maior destaque nos processos de qualidade a partir do momento em que ganha também importância o trabalho imaterial, cognitivo e linguístico, como gerador de valor e inovação, configurando-se como elemento chave para a qualidade.

  12. Tratamiento Cognitivo-Conductual, Protocolizado y en Grupo, de la Fibromialgia

    Directory of Open Access Journals (Sweden)

    Mª Isabel Comeche Moreno

    2010-01-01

    Full Text Available El objetivo del presente trabajo es comprobar si un programa protocolizado de tratamiento cognitivo conductual, diseñado específicamente para ser aplicado en formato grupal a pacientes de fibromialgia, puede ayudar a mitigar los problemas emocionales y mejorar el afrontamiento de la enfermedad. En el estudio participaron un total de 34 pacientes diagnosticados de fibromialgia, todos ellos pertenecientes a la Asociación de Fibromialgia de la Comunidad de Madrid (AFIBROM. El programa fue estructurado en 10 sesiones de dos horas de duración con una periodicidad semanal. En la evaluación pre y post-tratamiento, así como en el seguimiento realizado a los 3 meses, los participantes cumplimentaron los cuestionarios: Inventario de Depresión de Beck (BDI, Escala de Ansiedad y Depresión en Hospital (HAD, Escala de Autoeficacia (SES, Escala de Catastrofismo (PCS y Auto-registro del Dolor. Los resultados mostraron una mejoría clínica y estadísticamente significativa entre el pre y el post-tratamiento, en la variable depresión medida tanto con el BDI como con el HAD-D, así como en la variable ansiedad según el HAD-A. Esta mejoría se mantiene en el seguimiento realizado a los 3 meses de finalizado el tratamiento. Asimismo, al final de la intervención se observa un incremento estadísticamente significativo en todas las medidas de Autoeficacia y una disminución significativa de los pensamientos de Rumiación y Magnificación, mejoría que no se mantiene uniformemente en el seguimiento. Finalmente señalar que aunque tras la intervención se produce una bajada en el dolor medio informado por los pacientes, esta disminución no resulta estadísticamente significativa. Por todo ello puede concluirse que este programa de tratamiento protocolizado y en grupo ha demostrado ser eficaz para mitigar los problemas emocionales asociados a la fibromialgia, disminuir los pensamientos rumiativos y mejorar su percepción de autoeficacia en el afrontamiento

  13. Formas funcionales del potencial y la densidad electrónica para grafeno delta dopado

    Directory of Open Access Journals (Sweden)

    Francisco J. López-Rodríguez

    2013-01-01

    Full Text Available Establecemos las bases para el estudio del efecto de una línea extendida de impurezas sobre una placa d e grafeno. Mediante el uso de análisis dimensional y la propuesta de una ecuación de Poisson bidimensional, obtenemos las formas funcionales del potencial y la densidad electrónica de este problema.

  14. POTENCIAL DE LAS ABEJAS NATIVAS EN LA POLINIZACIÓN DE CULTIVOS

    OpenAIRE

    JOSE JAVIER QUEZADA-EUAN

    2009-01-01

    RESUMEN En esta nota se discute sobre la polinización de cultivos como una actividad potencial del cultivo de abejas nativas. Palabras clave: abejas nativas, polinación de cultivos ABSTRACT This note refers to the potential of native bees cultivation in crop polinization. Key words: native bees, crop polinization

  15. Modernización productiva y potencial de crecimiento en Hungría

    OpenAIRE

    Luengo Escalonilla, Fernando

    1997-01-01

    Análisis y balance de las reformas que se estan llevando a cabo en Hungría, examinando los factores de crecimiento de la economía y los requerimientos financieros de ese crecimiento, con el objetivo de identificar y evaluar el potencial competitivo de la economía húngara.

  16. Hipotiroidismo subclínico, depresión y deterioro cognitivo: experiencia en un centro de adultos mayores de Lambayeque

    Directory of Open Access Journals (Sweden)

    Carol Gonzales-Gonzales

    2014-10-01

    Full Text Available Introducción: El hipotiroidismo subclínico en adultos mayores es una enfermedad poco estudiada. Objetivos: Determinar la frecuencia de hipotiroidismo subclínico, depresión y deterioro cognitivo y explorar su asociación, en adultos mayores. Diseño: Estudio descriptivo, transversal; muestreo no probabilístico, consecutivo. Escenario: Centro de adultos mayores de EsSalud, Lambayeque, Perú. Métodos: En 2012 y 2014, y en una muestra de 84 pacientes, se cuantificó TSH y T4L mediante técnica ELISA. Se evaluó depresión con el test de Yesavage reducido y el déficit cognitivo con el mini mental test examination. Se determinó frecuencias, porcentajes y análisis inferencial exploratorio mediante el cálculo de razones de prevalencia, con intervalos de confianza al 95%, usando Epidat v 3.1. Principales medidas de resultados: Hipotiroidismo subclínico, depresión y deterioro cognitivo y su asociación. Resultados: Se estudió 65 mujeres (77% y 19 hombres (23%; en 11 (13,1% adultos mayores se halló hipotiroidismo subclínico, en 36 (42,9% depresión y en 11 (13,1% deterioro cognitivo. No se encontró asociación entre hipotiroidismo subclínico y depresión (RP: 0,85, IC95% 0,39 a 1,85; p 0,677 o deterioro cognitivo (RP: 2,48, IC95% 0,77 a 7,98; p 0,1349. Conclusiones: Existió una elevada frecuencia de hipotiroidismo subclínico, depresión, y deterioro cognitivo en los adultos mayores estudiados. No se evidenció asociación de hipotiroidismo subclínico con depresión o con deterioro cognitivo.

  17. Desenvolvimento motor e cognitivo de bebês de mães adolescentes e adultas: estudo longitudinal

    Directory of Open Access Journals (Sweden)

    Luana Silva de Borba

    2015-07-01

    Full Text Available DOI: http://dx.doi.org/10.5007/1980-0037.2015v17n4p438   Este estudo teve como objetivos investigar em bebês de mães adolescentes e adultas: (1 os fatores de risco para o desenvolvimento infantil; (2 as mudanças cognitivas e motoras ao longo de quatro meses, (3 as correlações entre o desenvolvimento motor e cognitivo ao longo de quatro meses. Estudo longitudinal com 40 bebês, 20 nascidos de mães adolescentes e 20 de mães adultas, provenientes dos municípios de Porto Alegre e Butiá, no Rio Grande do Sul, Brasil. Foram realizadas três avaliações do desenvolvimento motor e cognitivo, utilizando a Alberta Motor Infant Scale (AIMS e Bayley Scale of Infant Development II. Na postura supina da AIMS, observou-se diferença significativa entre os grupos na terceira avaliação. Os bebês das mães adolescentes apresentaram escores mais baixos em relação aos bebês de mães adultas. Os escores motores de cada postura da AIMS e o escore total AIMS apresentaram diferença significativa ao longo do tempo em geral e em cada grupo. O escore mental bruto da Bayley-II também apresentou diferença significativa ao longo do tempo em geral e em cada grupo. Observou-se associação positiva, forte e significativa entre os escores totais da AIMS e Bayley em todos os três momentos de avaliação no grupo de bebês de mães adolescentes e adultas. Pode-se concluir que bebês de mães adolescentes apresentaram-se piores na postura supina em relação aos bebês de mães adultas. Os desenvolvimentos motor e cognitivo se associaram significativamente em ambos os grupos ao longo do tempo.

  18. Desempenho cognitivo-linguístico de escolares com distúrbio de aprendizagem Rendimiento cognitivo-lingüístico de estudiantes con trastornos de aprendizaje Cognitive-linguistic performance of students with learning disabilities

    Directory of Open Access Journals (Sweden)

    Cláudia Silva

    2011-03-01

    Full Text Available O estudo tem como objetivo caracterizar e comparar o desempenho cognitivo-linguístico de escolares com distúrbio de aprendizagem com escolares com bom desempenho acadêmico. Participaram 40 escolares de 8 a 12 anos de idade, de 2ª a 4ª séries do Ensino Fundamental de escolas municipais da cidade de Marília - SP, divididos em GI (escolares com bom desempenho acadêmico e GII (escolares com distúrbio de aprendizagem. Como procedimento foi utilizado o Teste de Desempenho Cognitivo-Linguístico, versões coletiva e individual. Os resultados evidenciaram desempenho superior do GI em relação ao GII nas habilidades de leitura, escrita, velocidade de processamento, processamento auditivo e visual. Concluiu-se que o desempenho inferior do GII nas habilidades indica uma limitação no desempenho linguístico desses escolares se comparados com os do GI, exceto na habilidade de consciência fonológica, em que, os grupos apresentaram dificuldades semelhantes, sugerindo que essa dificuldade não seja específica de escolares com distúrbio de aprendizagem.El estudio tiene como objetivo caracterizar y comparar el rendimiento cognitivo-lingüístico de estudiantes con trastornos de aprendizaje con estudiantes con buen rendimiento académico. Los participantes fueron 40 niños escolares de 8 a 12 años de edad, de 2º a 4º grados de la escuela primaria de la ciudad de Marília-SP. Fueron divididos en GI (estudiantes con buen rendimiento académico y GII (estudiantes con trastornos de aprendizaje. El procedimiento utilizado fue la prueba de rendimiento cognitivo-lingüístico, colectivo e individual. Los resultados sugieren desempeño superior del GI si comparado con GII en las habilidades de lectura, escrita, velocidad de procesamiento, procesamiento auditivo y visual. Conclusión: el rendimiento inferior de GII en las habilidades apuntando a una limitación en la actuación lingüística de los estudiantes frente al GI, excepto en la habilidad de

  19. Perfil cognitivo en pacientes con infección por el virus de inmunodeficiencia humana neurológicamente asintomáticos

    Directory of Open Access Journals (Sweden)

    Erik Guevara-Silva

    2013-01-01

    Full Text Available Introducción: Diversos estudios han comunicado la presencia de deterioro cognitivo asociado al virus de inmunodeficiencia humana (VIH tipo 1, aún en estadios tempranos de la infección. Las principales funciones comprometidas son la memoria a corto plazo, velocidad psicomotriz, atención y función ejecutiva. Objetivos: Describir el perfil cognitivo en pacientes con VIH neurológicamente asintomáticos, antes de iniciar terapia antirretroviral de gran actividad (TARGA, y determinar posibles factores asociados. Diseño: Estudio transversal-analítico. Lugar: Hospital Regional de Huacho. Participantes: Pacientes con VIH y con criterios para ingresar a TARGA. Intervenciones: Veintiún pacientes con VIH, que fueron atendidos desde de abril a julio de 2011, fueron evaluados clínicamente y se les administró una batería neuropsicológica estandarizada. Principales medidas de resultados: Puntajes alcanzados en las pruebas de velocidad psicomotriz, función ejecutiva, memoria inmediata, atención y habilidades visuoespaciales. Resultados: El 47,6% de pacientes presentó un deterioro cognitivo significativo. Los pacientes fallaron principalmente en las pruebas de velocidad psicomotriz y función ejecutiva. Con excepción de un paciente, todos fracasaron en al menos un test. La edad, tiempo de enfermedad, grado de instrucción y depresión no influyeron significativamente sobre el perfil cognitivo. Conclusiones: Estos hallazgos sugieren que el compromiso cognitivo en algún grado puede presentarse desde las fases tempranas y asintomáticas de la infección por el VIH; estos hallazgos coinciden con la literatura.

  20. Maltrato infanto juvenil en discapacitados cognitivos Infantile-juvenile ill-treatment in cognitive handicapped

    Directory of Open Access Journals (Sweden)

    Nadieska Benítez Gort

    2010-06-01

    Full Text Available El maltrato infantil es uno de los temas más álgidos dentro de la práctica médica pediátrica; si a esto se le suma la condición de discapacidad cognitiva que convierte a niños y adolescentes en población más expuesta y menos apta para identificarlo y defenderse, se estaría tratando un problema médico de alta complejidad. Es importante el conocimiento de este tema en el personal de salud más cercano a la familia, lo que puede contribuir a la disminución de la frecuencia del maltrato y a reducir el tiempo de daño al niño o adolescente. Todo lo anterior puede evitar que estos pequeños sean mal diagnosticados y mal tratados a punto de partida de la desorganización conductual y emocional que en ellos pueden aparecer secundarios al maltrato, muchas veces inexplicables para padres y médicos. Es importante poner a disposición de los especialistas de la atención primaria y personal de salud comunitario, algunos apuntes sobre las particularidades del maltrato infantil en niños y adolescentes con necesidades cognitivas especiales, sus causas, tipos y consecuencias más frecuentes para su salud mental. El maltrato infanto juvenil en discapacitados cognitivos no es probablemente infrecuente en las comunidades y sí quizás poco identificado. La capacidad del personal de salud para encontrarlo siempre será oportuna y salvadora, de ahí la necesidad de conocimientos sobre el tema.The infantile ill-treatment is one of the more inhuman subjects in the pediatric medical practice and if to this feature we added the cognitive inability status converting children and adolescents into a more exposed and less able population to identify it and to defend itself, this will becomes in very complex medical problem. It is important the knowledge of this subject by health staff nearest of family, contributing to decrease of ill-treatment frequency and reducing the damage time to child or adolescent. The above mentioned may to avoid that these little

  1. Interacción en el aula: de lo cognitivo a lo afectivo

    Directory of Open Access Journals (Sweden)

    Deisy ROMÁN

    2009-11-01

    Full Text Available RESUMEN: La presente es una investigación cuyo propósito es explorar las relaciones sociales que se dan dentro del aula y proponer algunas acciones tendentes a mejorar las mismas en dos secciones de 6o. Grado en un colegio de Maracaibo, Venezuela, durante el año escolar 1998-1999. Este estudio tiene su referente en las teorías cognitivas sociales de Kelly (1955 y de Rotter (1966, quienes apuntan sobre la existencia de elementos tales como los constructos y las expectativas del refuerzo, respectivamente, como determinantes de la evolución psicosocial de la persona. Para la obtención de los datos se procedió a desarrollar el estudio en tres fases: la primera referida a la realización de un emblema distintivo de cada grupo; la segunda, se trataba de la aplicación de un cuestionario sociométrico; y, la tercera, estaba relacionada a las acciones aplicadas por los docentes sobre la base del conocimiento que tenían de los grupos, el cual provenía de la interacción profesor-alumno y de los resultados del cuestionario sociométrico. Los resultados apuntan sobre el hecho de que la interacción en el aula está descrita por los elementos cognitivos de las relaciones interpersonales, por las relaciones interpersonales y por las características de los grupos de trabajo y la intervención en los grupos ha permitido mejorar en gran medida la calidad de las relaciones interpersonales y el clima en el aula.ABSTRACT: The following is an research whose purpose was to find out the social relationship that took place into the classroom and to propose some actions that try to improve it in the two sections of 6th grade of one school in Maracaibo, Venezuela, during the scholar period of 1998-1999. This research has its referent in the social cognitive theories of Kelly (1955 and Rotter (1966 who talk about the existence of elements such as constructs and effort expectations, respectively, as determiners of the psychosocial evolution of people. To obtain

  2. Funcionamento cognitivo e habilidades metalinguísticas na aprendizagem da leitura Funcionamiento cognitivo y habilidades metalingüísticas con el aprendizaje de la lectura Cognitive operation and metalinguistic abilities in reading learning

    Directory of Open Access Journals (Sweden)

    Sebastián Urquijo

    2010-12-01

    Full Text Available O objeto do trabalho é analisar as relações do funcionamento cognitivo e o domínio das habilidades metalinguísticas com a aprendizagem formal da leitura no primeiro ano do primeiro grau da escola básica. As habilidades metalinguísticas têm a ver com a reflexão consciente acima dos diferentes patamares do sistema linguístico e se desenvolvem na infância, aprimorando-se com a escolaridade. Pela sua parte, o funcionamento cognitivo envolve processos necessários para perceber, selecionar, processar e armazenar informação, tarefas de importância num complexo processo como a leitura. Foram avaliados 127 meninos e meninas, alunos do primeiro ano, do primeiro grau de duas escolas da rede municipal de ensino e duas escolas particulares da cidade de Mar del Plata, Argentina, a quem lhes foram administrados instrumentos para avaliar seus desempenhos em memória, atenção, funções executivas, raciocínio, habilidades metalinguísticas e leitura. Os resultados indicam, de forma sistemática, que tanto os processos cognitivos como as habilidades metalinguísticas associam-se de forma significativa ao desempenho em diferentes medidas de leitura. As conclusões discutem essas relações e destacam a influência dos fatores individuais no processo de aprendizagem da leitura.El objetivo de este trabajo es el de analizar las relaciones del funcionamiento cognitivo y el dominio de las habilidades metalingüísticas con el aprendizaje formal de la lectura durante el primer año de la escuela. Las habilidades metalingüísticas implican la reflexión conciente sobre los diferentes niveles del sistema lingüístico y se desarrollan durante la infancia, perfeccionándose con la escolaridad. Por otra parte, el funcionamiento cognitivo involucra procesos necesarios para percibir, seleccionar, procesar y almacenar información, tareas de relevancia en un proceso complejo como la lectura. Se evaluaron 127 niños y niñas, alumnos del primer año del ciclo

  3. A abordagem Cognitivo-Comportamental dos sonhos de alcoolistas El abordage Cognitivo-Comportamental de los sueños de alcoholicos Dreams of alcoholics according to Cognitive-Behavioural therapy

    Directory of Open Access Journals (Sweden)

    Renata Brasil Araujo

    2004-04-01

    Full Text Available Este trabalho tem por objetivo realizar uma revisão teórica a respeito do sono e dos sonhos de alcoolistas de acordo com a Terapia Cognitivo-Comportamental, aprofundando aspectos cognitivos e neurológicos. Na medida em que esta é a abordagem psicoterápica mais indicada para dependência química, os sonhos, utilizados na Terapia Psicanalítica, tiveram de ser estudados sob o enfoque cognitivo-comportamental, para que pudessem ser aproveitados na clínica com estes pacientes. As alterações no sono de alcoolistas, por exemplo, pode servir como alerta quanto a um risco de recaída, o que indica que a avaliação do sono não pode ser desconsiderada pelos profissionais, durante o tratamento destes pacientes. O relato dos sonhos, por sua vez, pode ser um instrumento terapêutico muito valioso por oferecer pistas a respeito do quanto o craving está presente naqueles que estão tentando manter-se em abstinência. Se os profissionais forem bem sucedidos quanto à identificação precoce de uma situação de risco como o craving, poderão ser mais efetivos quanto à prevenção da recaída. Conclui-se quanto à necessidade de que sejam feitas novas pesquisas a respeito dos sonhos de acordo com esta abordagem teórica, bem como avaliada a sua aplicação na área da dependência química.Este trabajo tiene como objetivo realizar uma revisión teórica a respecto del sueño y de los sueños de alcohólicos, teniendo en vista la Terapia Cognitivo-Comportamental, profundizando aspectos cognitivos y neurológicos. Em la medida en que éste es el abordaje psicoterápico más indicado para dependencia química, los sueños, utilizados en la Terapia psicoanalítica, tuvieron que ser estudiados sobre el enfoque cognitivo-comportamental, para que pudieran ser aprovechados en la clínica con estos pacientes. Las alteraciones em el sueño de los alcohólicos, por exemplo, pueden servir como alerta para el riesgo de recaída, lo que indica que una evaluaci

  4. ¿Crees en los fantasmas? Quizá estés mostrando un sesgo cognitivo

    Directory of Open Access Journals (Sweden)

    Fernando Blanco

    2016-01-01

    Full Text Available La ilusión causal es un sesgo cognitivo que consiste en la percepción de una relación de causa-efecto entre dos eventos que no están conectados entre sí. Este sesgo podría subyacer algunas creencias irracionales. En un experimento, exploramos la posibilidad de que la creencia en lo paranormal esté asociada a una mayor facilidad para desarrollar ilusiones causales. Los resultados indican que, efectivamente, los creyentes en lo paranormal tienen mayor ilusión causal en una tarea informatizada. Además, esta ilusión fue producida a su vez por un sesgo en la manera en que los creyentes en lo paranormal buscaron información durante la tarea.

  5. Relación entre ejercicio físico y procesos cognitivos en las personas mayores

    OpenAIRE

    Fortuño-Godes, Jesús

    2017-01-01

    Este artículo es una revisión bibliográfica que pretende reflejar el estado del arte de la relación entre práctica de ejercicio físico y los procesos cognitivos en la última fase de la vida de las personas. Diferentes estudios han relacionado la práctica del ejercicio con la reducción de síntomas de ansiedad y depresión, con la mejora del bienestar y con una menor prevalencia en la aparición de enfermedades como el Alzheimer, Parkinson y síntomas de demencia. La actividad física favorece aque...

  6. Procesos cognitivos en la composición escrita de niños con deprivación sociocultural

    Directory of Open Access Journals (Sweden)

    Antonio García Guzmán

    2003-01-01

    Full Text Available El objetivo de este artículo es analizar los procesos cognitivos implicados en la composición escrita que realizan los niños de etnia Gitana. Para ello, se ha realizado un estudio de casos, concretamente 3 alumnos, que han sido entrevistados sobre los distintos aspectos relacionados con la planificación, revisión, estructuración y autorregulación. Los datos arrojan algunas deficiencias en procesos como: el registro de ideas, la utilización de estrategias, la secuenciación de ideas, la organización general del texto y la falta de revisión en sus textos (ortografía y caligrafía.

  7. Avaliação do desenvolvimento cognitivo e afetivo-social de crianças com perda auditiva

    Directory of Open Access Journals (Sweden)

    Maria de Lourdes M. Tabaquim

    2013-12-01

    Full Text Available OBEJTIVO: avaliar o nível de desenvolvimento cognitivo e afetivo-social de crianças com diagnóstico de deficiência auditiva. MÉTODO: participaram do estudo 50 crianças com diagnóstico de deficiência auditiva, com idade média de 16,1 meses, de ambos os gêneros. Empregou-se a entrevista semi-estruturada com os pais para a obtenção da história de vida da criança, a Escala de Desenvolvimento Comportamental e a Escala de Avaliação da Reação de Retração do Bebê. RESULTADO: o estudo identificou 80% das crianças com perda auditiva profunda bilateral. O Quociente de Desenvolvimento na normalidade ocorreu em 76% da amostra, sendo as funções da linguagem e pessoal-social, as mais prejudicadas. Os níveis de ajustamento afetivo e interacional foram caracterizados pelas reações de alarme para problemas de interação pessoal-social. CONCLUSÃO: as competências defasadas de habilidades verbais e não-verbais mostraram implicações no desenvolvimento cognitivo, sugestivas da condição da criança com perda auditiva e dos fatores de risco associados, com limitação circunstancial a trocas comunicativas que promovem o desenvolvimento de competências adaptativas e o fortalecimento da auto-estima para as relações.

  8. VALIDEZ DE LA CONEXIÓN INTERLEXICA ASEMÁNTICA EN EL MODELO COGNITIVO DE PROCESAMIENTO DE PRAXIAS

    Directory of Open Access Journals (Sweden)

    P. G. Gómez

    2011-01-01

    Full Text Available González Rothi et al. (1991, 1997 postularon un modelo cognitivo de praxias, sobre el que fueron propuestas modificaciones (Cubelli et al., 2000, entre ellas la supresión de la vía directa entre el praxicón de entrada y el praxicón de salida. Se planteó que para validar una vía interlexica asemántica (Cubelli et al., 2000, sería suficiente el hallazgo de un paciente con habilidad conservada de imitar gestos familiares, pero con alteraciones en la capacidad de acceder al significado de gestos familiares y alteraciones en la habilidad de imitar gestos no familiares. El objetivo de este trabajo es presentar dos pacientes cuyos patrones de rendimiento práxico apoyan la existencia de una vía interlexical asemántica.Se evaluó a 2 pacientes con diagnóstico de demencia tipo Alzheimer probable con una batería de evaluación cognitiva de apraxias (Politis 2003. Ambos pacientes evidencian alteraciones en la prueba de imitación de gestos no familiares y en las tareas que evalúan semántica de la acción (apareamiento objeto-herramienta y denominación por función, con buen rendimiento en la tarea de la imitación de gestos familiares. Tomando como base los modelos cognitivos de praxias de González Rothi et al. (1991, 1997 y Cubelli et al. (2000 es necesaria una conexión directa entre el praxicón de entrada y el praxicón de salida para explicar el rendimiento de estos pacientes. De este modo, el patrón de rendimiento que muestran ambos pacientes confirmaría la existencia de una vía interléxica asemántica.

  9. H3+: superficies de energía potencial, estados y transiciones rovibracionales

    Science.gov (United States)

    Aguado, M. Paniagua Y. A.

    Hemos calculado varias superficies globales de energía potencial para el estado fundamental y excitados del sistema H3+ en más de ocho mil geometrías diferentes usando una base (9s 3p 1d)/[4s 3p 1d] en cada átomo de Hidrógeno y mediante un método de cálculo de interacción de configuraciones completa (FCI). Hemos ajustado las superficies a formas analíticas del tipo Aguado y Paniagua con un error promedio menor de 50 cm-1 y menor en el pozo de potencial del estado fundamental. Finalmente hemos calculado y analizado los niveles vibracionales para los dos estados electrónicos más bajos, siendo la desviación respecto de los mejores valores publicados, tanto experimentales como teóricos, de unos pocos números de onda.

  10. Energía mareomotriz: potencial energético y medio ambiente

    Directory of Open Access Journals (Sweden)

    Julián Rodrigo Quintero González

    2015-07-01

    Full Text Available La energía mareomotriz ha tenido un gran desarrollo en relación a su potencial energético y el estudio de sus impactos ambientales. Este trabajo presenta una perspectiva acerca de estos dos aspectos que han sido ampliamente evaluados en diferentes países. Se concluye que el potencial energético de la energía mareomotriz es significativo, en relación con las capacidades instaladas de las plantas de energía actualmente en operación, con el incremento de la producción energética anual y con el número de nuevos proyectos en el marco global. Se indica también que existen impactos ambientales moderados con su implementación.

  11. Prevalencia y estudio de factores asociados al deterioro cognitivo en personas mayores de 65 años del entorno de la farmacia comunitaria

    Directory of Open Access Journals (Sweden)

    Climent Catalá MT

    2012-09-01

    Full Text Available INTRODUCCIÓN El deterioro cognitivo y la demencia en la población anciana constituyen un problema de salud importante por su magnitud y gravedad. Estudios epidemiológicos apoyan la existencia de factores de riesgo de deterioro cognitivo prevenibles: factores vasculares y factores relacionados con el estilo de vida. El objetivo es detectar posibles casos de deterioro cognitivo en mayores de 65 años del entorno de la farmacia y analizar en un estudio posterior la eficacia de un programa de educación sanitaria para mejorar la función cognitiva. MATERIAL Y MÉTODOS Estudio transversal de prevalencia de deterioro cognitivo en personas mayores de 65 años. Los datos aportados en este estudio se obtuvieron de marzo a junio 2011, en cuatro farmacias de la Comunidad Valenciana. Recogemos: “hoja de consentimiento informado”, “registro Dader” y ”cuestionario específico de las variables a estudio”, cuestionario que recoge datos demográficos, de estilos de vida (ejercicio, lectura, sueño, patologías crónicas y tratamiento farmacológico. El test de cribado utilizado es el SPMSQ-Short (Portable Mental State Questionaire de Pfeiffer. Los pacientes con test de Pfeiffer positivo serán considerados casos y participarán posteriormente en un programa de intervención sanitaria de educación en “higiene del sueño”, “ejercicio físico” y “entrenamiento cognitivo”. RESULTADOS Han colaborado 245 pacientes: 97 hombres (40% y 148 mujeres (60%, lo que supone el 76% de los entrevistados. Nivel de estudios: analfabetos 26 (11%, primarios 125 (51%, secundarios 65 (26% y superiores 29 (12%. Presentan puntuación en Pfeiffer compatible con deterioro cognitivo 31 participantes (13%. El deterioro cognitivo es mayor entre los analfabetos (23% y aquellos que cursaron estudios primarios (13%, y menor entre los participantes que cursaron estudios superiores y los que practican diariamente la lectura. Entre los pacientes estudiados, hay una menor

  12. Potencial de fertilizantes e corretivos no aporte de micronutrientes ao solo

    OpenAIRE

    Vinícius Gedeão Bezerra de Carvalho; Clístenes Williams Araújo do Nascimento; Caroline Miranda Biondi

    2012-01-01

    Fertilizantes e corretivos, ao serem aplicados nos solos, fornecem micronutrientes como impurezas residuais da sua fabricação, os quais podem ser importantes fontes para as culturas. Em decorrência disso, o objetivo deste trabalho foi quantificar os teores dos micronutrientes Zn, Cu, Fe, Mn e Ni em fertilizantes e corretivos comercializados no Nordeste brasileiro, visando avaliar o potencial desses insumos no fornecimento indireto de micronutrientes às culturas agrícolas. Os insumos analisado...

  13. Contribuições de um treino cognitivo para a memória de idosos institucionalizados Contribuciones de un entreno cognitivo para la memoria de ancianos institucionalizados Contributions of a cognitive training for the memory of institutionalized elderly

    Directory of Open Access Journals (Sweden)

    Isabelle Patriciá Freitas Chariglione

    2013-04-01

    Full Text Available Este estudo investigou a influência de diferentes treinos cognitivos na memória de idosos institucionalizados e em medidas neuropsicológicas e de humor. Dezesseis idosos participaram do programa que incluiu dois tipos de treinamentos que variavam quanto à semelhança com as atividades e o ambiente dos idosos na instituição. Os treinos tinham a duração de 60 minutos e ocorreram duas vezes por semana durante quase quatro semanas. Os resultados mostraram que ARFC foi influenciado pelo tipo de treinamento, e que a recordação livre para palavras foi melhor após o treinamento somente para o grupo de idosos alfabetizados, independentemente do tipo de treinamento. Não foram detectados efeitos no teste de reconhecimento de imagem e as sessões de treinamento afetaram positivamente os escores EDG.Este estudio investigó la influencia de diferentes entrenos cognitivos en la memoria de ancianos institucionalizados y en medidas neuropsicológicas y del humor. Dieciséis ancianos participaron del programa que incluyó dos tipos de entrenamientos que variaban cuanto a la semejanza con las actividades y el ambiente de ancianos en la institución. Los entrenos tenían la duración de 60 minutos y ocurrieron dos veces por semana durante casi cuatro semanas. Los resultados mostraron que ARFC fue influenciado por el tipo de entrenamiento, y que el recuerdo libre para palabras fue mejor pasado el entrenamiento solamente para el grupo de ancianos alfabetizados, independientemente del tipo de entrenamiento. No fueron detectados efectos en el teste de reconocimiento de imagen y las sesiones de entrenamiento afectaron positivamente los escores EDG.This study investigated the influence of different cognitive training procedures in memory, neuropsychological measures and mood of institutionalized elderly. Sixteen seniors attended the program which included two types of procedures that varied in terms of the similarity to the daily activities and environment of

  14. Efecto de las estrategias didácticas activas en las actitudes hacia la química y su interacción con el estilo cognitivo

    Directory of Open Access Journals (Sweden)

    Gladys Elena Hurtado Osorio

    2015-01-01

    Full Text Available En este artículo se muestran y analizan los efectos en las actitudes hacia el aprendizaje de la química, con la aplicación de tres estrategias didácticas de enseñanza (aprendizaje basado en problemas — ABP— , aprendizaje por descubrimiento guiado —ADG — y enseñanza para la comprensión —EPC — en tres grupos de estudiantes de educación media, diferenciados por su estilo cognitivo en la dimensión dependencia- independencia de campo. Para el estudio se aplicó el instrumento de actitudes IAQ, que permite deter - minar las actitudes en tres dimensiones: afectiva, actitudinal y cognitiva. Los resultados mostraron, entre otros, una correlación significativa entre las actitudes en la dimensión cognitiva y el estilo cognitivo DIC.

  15. Estilos cognitivos de estudantes de psicologia: impacto da experiência em iniciação científica

    Directory of Open Access Journals (Sweden)

    Karina Brunini Pitta

    Full Text Available Esta pesquisa pretendeu verificar se há impacto das experiências em Iniciação Científica nos Estilos Cognitivos, segundo universitárias. A coleta de dados foi realizada com oito alunas de Psicologia, aplicandose uma escala e entrevistas. Os dados foram analisados quantitativa e qualitativamente. Constatou-se que: não há predominância dos Estilos quanto à área e modalidade de pesquisa; todos apresentaram Divergência de Pensamento e predomínio de Reflexividade de Resposta; a maioria concordou com os Estilos avaliados e considerou como positivos aqueles que se modificaram. As principais variáveis responsáveis pelas alterações foram: orientador, atividades e trabalho em grupo. Pode-se concluir que a Iniciação Científica é um dos fatores que interfere no desenvolvimento cognitivo dos estudantes.

  16. Programas psicosociales de intervención cognitiva en población con signos de deterioro cognitivo leve (DCL: Revisión de efectos y eficacia

    Directory of Open Access Journals (Sweden)

    Fátima González Palau

    2012-01-01

    Full Text Available Debido al incremento en el porcentaje de adultos mayores, así como de las enfermedades degenerativas, existe un creciente interés en la determinación de métodos psicosociales eficaces dirigidos a sujetos con Deterioro Cognitivo leve. Recientes estudios experimentales exponen efectos positivos de las intervenciones cognitivas dirigidas a esta población, tanto en métodos tradicionales y como en estrategias de intervención por medio de nuevas tecnologías. la presente revisión proporciona un análisis sistemático de la literatura existente en miras de valorar el efecto y los alcances de las intervenciones cognitivas no farmacológicas existentes en la actualidad, dirigidas a adultos mayores con Deterioro Cognitivo leve.

  17. Un método cognitivo para la enseñanza-aprendizaje de la ortografía en adultos

    OpenAIRE

    Valencia de Abadia, María Eugenia; Idrobo Figueroa, James E.

    2010-01-01

    Este artículo presenta la formulación de un método cognitivo para la enseñanza aprendizaje de la ortografía, dirigido a adultos con nivel de educación media. Es el resultado de un trabajo investigativo, interdisciplinario, realizado por los autores en la Universidad del Valle y con base en él se está desarrollando un producto de software educativo en la misma institución

  18. Desempenho cognitivo-linguístico de crianças com fissura labiopalatina em fase de aquisição da leitura e escrita

    Directory of Open Access Journals (Sweden)

    Shaday Prudenciatti

    Full Text Available RESUMO Objetivo: identificar as competências cognitivo-linguísticas necessárias ao aprendizado da leitura e da escrita de crianças com fissura labiopalatina. Métodos: participaram 120 crianças, de 05 e 06 anos, cursando o Jardim II e o 1º ano do ensino fundamental, compondo dois grupos: G1, formado por 60 crianças com fissura labiopalatina, e G2, com 60 crianças sem alterações no desenvolvimento. Empregaram-se as Matrizes Progressivas Coloridas de Raven, o Perfil de Habilidades Fonológicas e o Boston Naming Test. Resultados: comparando os desempenhos dos grupos, verificou-se diferença estatística nas funções intelectuais, indicando prejuízos nas habilidades cognitivas do G1 (p=0,019. As competências cognitivo-linguísticas foram classificadas “Sob Atenção” para ambos os grupos, sendo mais representativa a defasagem no G1, com 66,7%. Conclusão: as competências linguísticas necessárias para a aquisição da leitura e escrita mostraram-se deficitárias na população fissurada, com níveis de desempenho cognitivo inferior ao esperado para a idade e escolaridade, em grande parte das modalidades avaliadas. Fatores ambientais limitantes e o baixo nível sociocultural da amostra foram sugestivos de interferência adicional à aquisição das pré-competências cognitivo-linguísticas, necessárias ao desempenho satisfatório de tarefas acadêmicas como a leitura e escrita.

  19. Funcionamiento cognitivo de niños entre 4 y 6 años para la resolución de conflictos interpersonales

    Directory of Open Access Journals (Sweden)

    María Paola Ayala Afanador

    2011-01-01

    Full Text Available Esta investigación se centra en el estudio de aspectos del funcionamiento cognitivo de los niños en el dominio del conocimiento social, partiendo del uso de Situaciones de Resolución de Problemas (SR P. Se busca indagar la forma en la cual los niños resuelvan conflictos interpersonales y utilicen la toma de perspectiva como habilidad social. El objetivo general del proyecto es describir los funcionamientos cognitivos de 20 niñas y niños entre cuatro y seis años de edad, para la resolución de conflictos interpersonales, a través de los desempeños obtenidos en una tarea,que simula tres escenarios con situaciones de disputa entre varios personajes. Los resultados demuestran que los niños en edad escolar son capaces de incorporar habilidades sociales desde edades tempranas. Este hecho sustenta la idea de que el desarrollo cognitivo, especialmente en el dominio social, no requiere de un funcionamiento general, sino que presenta variabilidad en periodos cortos de tiempo respecto a la resolución de conflictos interpersonales, e incluso en micro momentos dentro de la misma tarea.

  20. O papel dos estados afetivos sobre os processos cognitivos de assimilação e acomodação

    Directory of Open Access Journals (Sweden)

    Maura Ribeiro Alves

    2011-12-01

    Full Text Available Este artigo objetivou investigar se o humor positivo induz ativação de conhecimento prévio (função assimilativa e se o humor negativo aciona processos cognitivos dirigidos pelos dados (função acomodativa. A amostra foi composta de 32 participantes, de ambos os sexos, com idade entre 17 e 38 anos. O experimento testou o efeito de geração ativa de conhecimento. Induziram-se inicialmente humores positivos e negativos nos participantes. A tarefa final consistiu em recordar livremente uma lista de palavras completas (favorecendo processos dirigidos pelos dados ou incompletas (favorecendo processos cognitivos dirigidos por conhecimento prévio via geração ativa, apresentadas anteriormente. Sob humor positivo, os participantes recordaram mais palavras completadas por eles durante a fase de codificação (efeito de geração ativa, sugerindo prevalência de funções assimilativas. Sob estado de humor negativo, recordaram mais palavras completas oferecidas pelo experimentador, indicando predomínio de funções acomodativas. Conclui-se que os estados afetivos atuam sobre a seleção e regulação dos processos cognitivos de assimilação e acomodação.

  1. Caracterização dos distúrbios cognitivos na Doença de Parkinson Characterizing cognitive disorders in Parkinson's disease

    Directory of Open Access Journals (Sweden)

    Mônica Maria de Azevedo Mello Carvalho Galhardo

    2009-01-01

    Full Text Available TEMA: comprometimentos cognitivos na doença de Parkinson. OBJETIVO: ressaltar a existência do déficit cognitivo na Doença de Parkinson, descrevendo as características dos comprometimentos cognitivos. CONCLUSÕES: as alterações cognitivas na Doença de Parkinson (referentes a memória, linguagem, capacidade visuo-espacial e funções executivas são constatadas na literatura, no entanto, há uma carência de informações quanto à reabilitação fonoaudiológica de pacientes nessa área específica da linguagem.BACKGROUND: cognitive commitments in Parkinson's disease. PURPOSE: to point out the existence of cognitive deficit in Parkinson's disease, describing its characteristics. CONCLUSIONS: cognitive alterations in Parkinson's disease (such as memory, language, visual-spatial capacity and execution functions are found in the literature, however, there is a lack of information such as the speech therapist rehabilitation of patients in such -specific language-related area.

  2. Consciência situacional, tomada de decisão e modos de controle cognitivo em ambientes complexos Situation awareness, decision making, and cognitive control in complex environments

    Directory of Open Access Journals (Sweden)

    Éder Henriqson

    2009-01-01

    Full Text Available O presente trabalho tem como objetivo analisar a consciência situacional, os processos de tomada de decisão naturalística e os modos de controle cognitivo utilizados por pilotos de aeronaves em um experimento em simulador de voo. Dessa forma, diferentes situações foram propostas durante a simulação objetivando o estudo da consciência situacional e tomada de decisão dos tripulantes. As ações dos participantes foram investigadas e classificadas de acordo com o modelo de controle cognitivo proposto. Os resultados sugerem que os fatores de complexidade contextual afetam a gestão da dificuldade, influenciando a consciência situacional, a tomada de decisão e os modos de controle cognitivo dos pilotos.This work aims to analyze situation awareness, natural decision-making processes and cognitive control modes used by airplane pilots in a flight simulator experiment. In this way, different situations during flight simulation were considered in order to study the crew's situation awareness and natural decision-making. The participants' actions were investigated and classified according to the cognitive control model proposed. Results suggest that context complexity factors affect difficulty management, influencing situation awareness, decision-making and pilots' cognitive control modes.

  3. Aspectos cognitivos relacionados à noção de intervalos de tempo Cognitive aspects related to time interval notion

    Directory of Open Access Journals (Sweden)

    Liliane Cristina de Além-Mar e Silva

    2007-01-01

    Full Text Available OBJETIVO: Procuramos analisar os aspectos cognitivos e metodológicos envolvidos na avaliação da noção de intervalos de tempo, verificando os aspectos cognitivos envolvidos durante a sua execução, e apontar a relevância, aplicabilidade e sensibilidade dessa avaliação no exame neuropsicológico. MÉTODOS: Realizou-se revisão bibliográfica abrangendo artigos e pesquisas das literaturas nacional e internacional no período de 1990 a 2005. RESULTADOS: Encontraram-se 13 diferentes estudos. São controversas as discussões acerca de teorias sobre a noção de tempo. Os estudos podem ser agrupados de acordo com duas perspectivas diferentes: a teoria da contagem atencional, de grande utilização por pesquisadores americanos, e a teoria do relógio interno, muito abordada por estudiosos franceses que se diferem tanto em relação à abordagem teórica quanto à metodológica. CONCLUSÕES: Ambos os grupos de pesquisa, americanos e franceses, retratam a relevância da aplicação dos testes de estimativa, reprodução e produção de tempo no estudo das funções executivas.OBJECTIVE: We tried to analyze the cognitive and methodological aspects involved in the evaluation of time intervals notion, verifying the cognitive aspects involved during your execution, and to point the relevance, applicability and sensibility of this evaluation in the neuropsychologic exam. METHODS: Bibliographical revision was accomplished including articles and researches of the national and international literature in the period of 1990 to 2005. RESULTS: Were found 13 different researches. The discussions concerning theories about the time notion are controversial. These studies can be grouped into two different perspectives: the attentional counter theory, used by American researchers, and the internal clock theory, very boarded by French studious, that are differed in relation to the theoretical and to the methodological approaches. CONCLUSIONS: Both research groups

  4. Alteraciones hipocampales y cambios cognitivos preceden al deposito de placas amiloides en un modelo murino de la enfermedad de Alzheimer

    Directory of Open Access Journals (Sweden)

    Juan Beauquis

    2014-08-01

    Full Text Available Existen múltiples evidencias de alteraciones neuronales y gliales en etapas avanzadas de la enfemedad de Alzheimer con abundantes depósitos cerebrales de beta amiloide, aunque hay pocos datos de cambios tempranos que podrían contribuir al desarrollo de la enfermedad. Evaluamos alteraciones morfológicas neuronales y gliales, y cambios cognitivos y emocionales tempranos en ratones transgénicos PDAPP-J20 (Tg, portadores del gen humano de APP (amyloid precursor protein mutado, a los 5 meses de edad, aún sin depósitos amiloides en el hipocampo y con niveles bajos de péptidos amiloides cerebrales. Mediante inmunohistoquímica para NeuN, los Tg presentaron menor número de neuronas piramidales y granulares en el hipocampo, junto con un menor volumen de la estructura, en comparación con los controles no transgénicos. La neurogénesis se encontró afectada, evidenciada por reducido número de neuronas DCX+ en el giro dentado. En la región CA3, hubo una menor densidad de sinaptofisina sugiriendo alteraciones sinápticas entre neuronas granulares y piramidales, sin cambios en la densidad de espinas dendríticas en CA1. Utilizando microscopía confocal, observamos una disminución del número de astrocitos GFAP+ con una reducción de la complejidad celular, sugiriendo atrofia glial. Se detectó un déficit cognitivo (reconocimiento de localización novedosa de un objeto y un aumento de la ansiedad (campo abierto en los Tg, con aumento en los núcleos c-Fos+ en amígdala, evidenciando el papel de la emocionalidad en los inicios de la enfermedad. El estudio de las alteraciones iniciales en la enfermedad amiloide podría contribuir al desarrollo de métodos de diagnóstico temprano y de terapéutica preventiva.

  5. Estudos cognitivos em ciência da informaçãoCognitive studies in information science

    Directory of Open Access Journals (Sweden)

    Gercina Ângela Borem de Oliveira Lima

    2003-05-01

    Full Text Available The study of the influences from Cognitive Sciences in the information Science. The Information Science has as objects of study the very basic concepts of information and knowledge. Since such concepts have an inherently trans-disciplinary character, the Information Science has been largely influenced by many disciplines, particularly the Cognitive Science. Regardless of this, it is observed that such concepts have not been properly discussed within the Information Science. To deal with this concern, it has been structured in the Escola de Ciência da Informação (ECI of the Universidade Federal de Minas Gerais (UFMG, a research group denoted “Cognitive Studies in Information Science”. This work aims to discuss the relationships between the Information Science and the Cognitive Science. In order to achieve this purpose, one formerly presents the major approaches within the Cognitive Science, contextualizing their aspects that mostly influence the Information Science, and then one discuss some perspectives for the future relationship of these two disciplines.O estudo da influência das Ciências Cognitivas na Ciência da Informação. A Ciência da Informação, que tem como objetos de estudo a informação e o conhecimento, discute-os sob vários pontos de vista, sendo um deles, o cognitivo. Observa-se que os conceitos não têm sido adequadamente discutidos à luz das Ciências Cognitivas, apesar da Ciência da Informação sofrer muitas influências daquela disciplina. Em função dessas questões, estruturou-se, na Escola de Ciência da Informação–ECI da Universidade Federal de Minas Gerais-UFMG, o Grupo de Pesquisa “Estudos Cognitivos em Ciência da Informação” – GECCI. Neste trabalho, marco inicial das discussões do grupo, tem-se o objetivo de discutir as relações da Ciência da Informação com as Ciências Cognitivas. Para melhor compreensão desse relacionamento, serão apresentadas as principais vertentes das ci

  6. Apert syndrome: factors involved in the cognitive development Síndrome de Apert: fatores relacionados ao desenvolvimento cognitivo destes pacientes

    Directory of Open Access Journals (Sweden)

    Adriano Yacubian-Fernandes

    2005-12-01

    Full Text Available Apert syndrome is characterized by craniosynostosis, symmetric syndactyly and other systemic malformations, with mental retardation usually present. The objective of this study was to correlate brain malformations and timing for surgery with neuropsychological evaluation. We also tried to determine other relevant aspects involved in cognitive development of these patients such as social classification of families and parents’ education. Eighteen patients with Apert syndrome were studied, whose ages were between 14 and 322 months. Brain abnormalities were observed in 55.6% of them. The intelligence quotient or developmental quotient values observed were between 45 and 108. Mental development was related to the quality of family environment and parents’ education. Mental development was not correlated to brain malformation or age at time of operation. In conclusion, quality of family environment was the most significant factor directly involved in mental development of patients with Apert syndrome.A síndrome de Apert é caracterizada por cranioestenose, sindactilia simétrica e outras malformações sistêmicas. O retardo no desenvolvimento neuropsicomotor é freqüentemente observado. Este trabalho tem como objetivo analisar as malformações do sistema nervoso central, o momento da cirurgia e a classe sócio-econômica associada ao nível educacional dos pais como variáveis que possam influenciar no desenvolvimento cognitivo. Foram estudados 18 pacientes com diagnóstico de síndrome de Apert com idade entre 14 e 322 meses e as alterações encefálicas foram observadas em 55,6%. O quociente de inteligência variou de 45 a 108 e estava correlacionado com a classe sócio-econômica e com o nível de instrução dos pais; não se correlacionou com as alterações encefálicas nem com o momento do tratamento neurocirúrgico. Em conclusão, a condição sócio-econômica e o nível de instrução dos pais foram relevantes na determinação do

  7. Estudo eletrofisiológico do sistema auditivo periférico e central em indivíduos afásicos Electrophysiological study of the central and peripheral hearing system of aphasic individuals

    Directory of Open Access Journals (Sweden)

    Kátia de Freitas Alvarenga

    2005-03-01

    Full Text Available TEMA: Eletrofisiologia do sistema auditivo. OBJETIVO: Avaliação eletrofisiológica do sistema auditivo periférico e central de pacientes lesionados cerebrais. MÉTODO: Grupo experimental: onze lesionados cerebrais com quadros afásicos, de ambos os gêneros e idade variando de 43 a 75 anos; grupo controle: onze sujeitos sem queixa auditiva, equiparados quanto ao gênero e idade. Os indivíduos foram avaliados por meio de potenciais evocados auditivos de tronco encefálico (PEATE; de média latência (PEAML e potencial cognitivo (P300. RESULTADOS: Aumento das latências da onda V e do interpico I-V nos PEATE em ambos os grupos decorrente do fator idade. Presença de diferença hemisférica estatisticamente significante ao comparar o componente Pa na pesquisa dos PEAML registrado em C3 (hemisfério esquerdo e C4 (hemisfério direito no grupo experimental. Ausência ou aumento da latência e diminuição da amplitude do P300 na presença do componente N2, na pesquisa do potencial cognitivo P300. CONCLUSÃO: Os PEAML e P300 demonstraram ser instrumentos para avaliação de indivíduos afásicos.SUBJECT: Electrophysiology of the auditory system. OBJECTIVE: Electrophysiological evaluation of the peripheral and central auditory system of brain injured patients. METHOD: Experimental group: eleven brain injured and aphasic subjects, both genders and with ages ranging from 43 to 75; control group: eleven individuals without hearing complaints, equalized as to gender and age. The subjects were evaluated through auditory brainstem response (ABR; auditory middle latency response (AMLR and auditory P300 response. RESULTS: An increase in the V wave latency and I-V interpeak in both groups, due to the age factor. The presence of statistically significant hemispheric differences when compared to the Pa component in MLAEP research, registered in the C3 (left hemisphere and the C4 (right hemisphere. In researching the P300 Cognitive Potential, there was an

  8. Itervenção cognitivo-comportamental em violência sexual: estudo de caso Itervención de cognitivo-comportamental en un caso de violencia sexual Cognitive-behavior intervention with sexual violence: case report

    Directory of Open Access Journals (Sweden)

    Eliane Regina Lucânia

    2009-12-01

    Full Text Available Violência sexual é um grave problema de saúde pública, pois atinge todas as classes sociais, etnias, religiões e culturas, em especial crianças e adolescentes do sexo feminino. O objetivo do presente estudo é relatar o impacto de uma intervenção cognitivo-comportamental em uma adolescente de 13 anos, vítima de tentativa de estupro. O processo, de 45 sessões, distribuídas em avaliação inicial, intervenção, avaliação final e follow-up, utilizou entrevista semidirigida, critérios diagnósticos do DSM-IV, o Inventário de Depressão para Crianças (CDI, técnicas cognitivo-comportamentais e orientações à mãe. Na avaliação inicial verificaram-se dificuldades escolares, problemas comportamentais, sintomas indicativos de estresse pós-traumático e sintomas moderados de depressão, intensificados pelo episódio da violência. Observaram-se também repetições de padrões transgeracionais: comportamento promíscuo, etilismo, violência sexual e instabilidade nos relacionamentos. Os resultados demonstraram redução das queixas iniciais, aquisição de novo repertório comportamental, melhor funcionamento psicossocial e impacto positivo da intervenção. Os dados indicam necessidade de inclusão dos familiares no processo.La violencia sexual es un problema grave de la salud pública: alcanza todas las clases sociales etnias, religiones y culturas, en especial niños y adolescentes del sexo feminino. El objetivo del actual estudio es decir el impacto de la intervención cognitivo-comportamental en una adolescente de 13 años, víctima de un intento de violación. El proceso, de 45 sesiones, distribuido en la evaluación inicial, intervención, evaluación final y acompanãmiento, entrevista semidirigida, criterios diagnósticos del DSM-IV, inventario de depresión para los niños (CDI, técnicas cognitivo-comportamentales y orientación con la madre. En la primera entrevista fueron diagnosticadas dificultades en la escuela

  9. Dementia and mild cognitive impairment in patients with Parkinson's disease Demência e transtorno cognitivo leve em pacientes com doença de Parkinson

    Directory of Open Access Journals (Sweden)

    Gloria Maria Almeida Souza Tedrus

    2009-06-01

    Full Text Available The objective of this research was to assess the occurrence of cognitive impairment in 32 individuals (average age: 67.2 years old with Parkinson' disease (PD. Procedures: clinical-neurological assessment; modified Hoehn and Yahr staging scale (HYS; standard neuropsychological battery of CERAD (Consortium to Establish a Registry for Alzheimer' Disease; Pfeffer questionnaire; and Clinical Dementia Rating. A comparison was made with a control group (CG, consisting of 26 individuals with similar age and educational level but without cognitive impairment. The PD patients showed an inferior performance in the CERAD battery when compared to the CG. Three PD sub-groups were characterised according to cognition: no cognitive impairment - 15 cases; mild cognitive impairment - 10; dementia - 7 cases. There was a significant association between motor disability (HYS and the occurrence of dementia. Dementia and mild cognitive impairment frequently occur in PD patients and should be investigated in a routine way.O objetivo desta pesquisa foi avaliar a ocorrência de déficits cognitivos em 32 indivíduos (idade média: 67,2 anos com doença de Parkinson (DP. Procedimentos: avaliação clínico-neurológica, escala de Hoehn and Yahr modificada (EHY, bateria neurospicológica do CERAD (Consortium to Establish a Registry for Alzheimer' Disease, questionário de Pfeffer e escore clínico da demência (Clinical Dementia Rating. Foi feita comparação com grupo controle (GC de 26 indivíduos sem declínio cognitivo, com idade e nível educacional similares. Os pacientes com DP tiveram desempenho inferior na bateria CERAD, quando comparados ao do GC. Foram caracterizados 3 subgrupos com PD segundo a cognição: sem déficits cognitivos - 15 casos; transtorno cognitivo leve - 10; demência - 7 casos. Houve associação entre comprometimento motor e ocorrência de demência. Demência e transtorno cognitivo leve são freqüentes em pacientes com DP e devem ser

  10. Estabilidade dos potenciais evocados auditivos em indivíduos adultos com audição normal Stability of auditory evoked potentials in adults with normal hearing

    Directory of Open Access Journals (Sweden)

    Carla Gentile Matas

    2011-03-01

    Full Text Available OBJETIVO: Avaliar a estabilidade dos parâmetros dos potenciais evocados auditivos em adultos normais. MÉTODOS: Foram submetidos à avaliação audiológica e eletrofisiológica (potencial evocado auditivo de tronco encefálico - PEATE, potencial evocado auditivo de média latência - PEAML e potencial cognitivo - P300 49 indivíduos normais, de 18 a 40 anos (25 do gênero feminino e 24 do gênero masculino. Realizou-se reavaliação três meses após a avaliação. RESULTADOS: Foram observadas diferenças entre os gêneros na avaliação para as latências das ondas III e V e interpicos I-III e I-V do PEATE e amplitude N2-P3 do P300. Não foram verificadas diferenças significativas para os parâmetros do PEATE, PEAML (latência das ondas Na, Pa e amplitude Na - Pa e P300 (latência da onda P300 entre os resultados obtidos na avaliação e reavaliação. CONCLUSÃO: Exceção feita à amplitude N2-P3, observou-se estabilidade dos parâmetros de PEATE, PEAML e P300 em adultos normais após período de três meses.PURPOSE: To evaluate the stability of parameters of auditory evoked potentials in normal adults. METHODS: Forty-nine normal subjects with ages from 18 to 40 years (25 females and 24 males were submitted to audiological and electrophysiological hearing evaluation (auditory brainstem response - ABR, middle latency response - MLR, and cognitive potential - P300. Subjects were reassessed three months after the initial evaluation. RESULTS: Significant differences were observed between genders regarding the wave latencies III and V and the interpeaks I-III and I-IV of ABR, and the amplitude N2-P3 of the P300. No differences were found between the results of initial and final assessments for the parameters of the ABR, MLR (Na, Pa latencies and Na-Pa amplitude and P300 (P300 latency. CONCLUSION: Except for the N2-P3 amplitude, it was observed stability of the parameters of ABR, MLR and P300 in normal adults after a period of three months.

  11. Modificación de la personalidad mediante una terapia cognitivo-conductual de afrontamiento al estrés

    Directory of Open Access Journals (Sweden)

    Julia Linares-Ortiz

    2014-01-01

    Full Text Available El objetivo de este estudio ha sido comprobar la posibilidad de modulación de variables de personalidad (tales como algunos de los Cinco Grandes Factores, o la personalidad resistente a través de la aplicación de un programa de afrontamiento del estrés. Para ello, han participado 26 personas del ámbito universitario con alto estrés percibido, distribuidas en dos grupos (grupo de tratamiento y grupo de control. Los instrumentos de evaluación seleccionados se clasificaron en dos grupos: variables psicológicas y emocionales y variables de personalidad. Los resultados encontrados mediantes un ANOVA de medidas repetidas mostraron que existía interacción momento x grupo en las variables optimismo, extraversión y responsabilidad, correspondientes al Modelo de los Cinco Grandes Factores, mostrando un incremento de las puntuaciones en estas variables en el grupo terapia y no encontrándose dicha interacción en el grupo control. Las puntuaciones en los componentes de neuroticismo, amabilidad, apertura a la experiencia y personalidad resistente no se modificaron en ninguno de los dos grupos. Este estudio apoya la idea de que modificando determinados parámetros emocionales relacionados con el estrés mediante terapia cognitivo-conductual se pueden ver modulados algunos factores de personalidad.

  12. Caracterização do Perfil Cognitivo-Linguístico de Escolares com Dificuldades de Leitura e Escrita

    Directory of Open Access Journals (Sweden)

    Olga Valéria C. A. Andrade

    2014-01-01

    Full Text Available Investigou-se o perfil cognitivo-linguístico de escolares com dificuldades na aquisição da linguagem escrita acrescentando-se testes específicos em um modelo de resposta à intervenção (identificação e intervenção precoces do risco para transtorno de leitura. Participaram 45 escolares do 2º ano, idade média de 7 anos de ambos os gêneros, divididos em grupo controle (sem dificuldades, n = 32 e grupo de risco (com dificuldades, n = 13. Escores mais de 1,65 DP abaixo da média do grupo controle para cada teste foram considerados déficits específicos. Enquanto a análise de grupo apontou os prejuízos fonológicos como único fator de risco, a individual acrescentou a inatenção e a nomeação rápida como fatores causais independentes. Um modelo ampliado de resposta à intervenção que inclui a avaliação cognitiva é proposto.

  13. Temperamento e Caráter na Resposta à Terapia Cognitivo-Comportamental para Transtorno de Pânico

    Directory of Open Access Journals (Sweden)

    Débora Cassiane Finkler

    Full Text Available RESUMO O estudo investigou o impacto das características de temperamento e caráter na resposta à terapia cognitivo-comportamental (TCC para pacientes com transtorno de pânico (TP. Um total de 55 pacientes realizou 12 sessões de TCC em grupo (TCCG. A gravidade dos sintomas foi verificada antes e após a intervenção, e o Inventário de Temperamento e Caráter de Cloninger foi aplicado no início do tratamento. Observou-se uma redução significativa na gravidade do TP após a intervenção. Análises de regressão indicaram que as características de temperamento (persistência e caráter (autodirecionamento e cooperatividade não se mostraram significativamente relacionadas à melhora da agorafobia e de sintomas depressivos, permanecendo a gravidade inicial desses sintomas como fatores independentes de resposta à TCCG.

  14. El disfraz de la competitividad y la producción de conocimientos en el capitalismo cognitivo

    Directory of Open Access Journals (Sweden)

    César Guzmán Tovar

    2009-01-01

    Full Text Available La producción de bienes inmateriales, entre los cuales el conocimiento ocupa un lugar preponderante, es identificada como la principal actividad económica dentro de la estructura de las sociedades contemporáneas, particularmente en los países industrialmente desarrollados. Sin embargo, es importante indagar cuáles son los principios ideológicos y políticos que sostienen esta idea generalizada de la llamada sociedad del conocimiento. Así pues, actualmente la educación es entendida como uno de los principales mecanismos bajo los cuales se proyecta la dimensión económica en el campo de la producción de conocimientos; desde este punto de vista se plantea que la racionalidad propia del mercado neoliberal ha influenciado fuertemente los campo epistemológicos y discursivos de las universidades a través de nociones tales como competencia, eficiencia y capital humano. El presente artículo discute acerca de la implementación de las competencias estandarizadas, las cuales han sido establecidas como legítimas por las universidades. Toda esta dinámica opera mediante los principios del Capitalismo cognitivo, el cual es entendido como una compleja red que cubre las dimensiones políticas, económicas y sociales de la sociedad contemporánea.

  15. Incidencia de la realidad aumentada sobre el estilo cognitivo: caso para el estudio de las matemáticas

    Directory of Open Access Journals (Sweden)

    Rubén Darío Buitrago-Pulido

    2015-01-01

    Full Text Available Esta investigación analiza la asociación entre el logro de aprendizaje en matemáticas, el estilo cognitivo en la dimensión dependencia-independencia de campo y la realidad aumentada (RA en un ambiente virtual de aprendizaje. Para cumplir con el objetivo propuesto, se estructuró un estudio cuantitativo de tipo descriptivo-correlacional, con diseño de corte cuasiexperimental con dos grupos: uno experimental y otro de control con pretest y postest no equiparables. En el estudio participaron 83 estudiantes de la Escuela Colombiana de Carreras Industriales (ECCI de Bogotá, del Programa de Ingeniería Industrial. Los resultados indican que el uso del paradigma de la realidad aumentada, implementada como estrategia de interacción natural con objetos digitales para el aprendizaje defunciones en varias variables, permitió obtener mejores resultados de forma efectiva y significativa en cuanto al logro de aprendizaje en estudiantes que cursaron la unidad didáctica Cálculo Vectorial, cuya tipología en la dimensión DIC es intermedia e independiente.

  16. Evidências científicas das neurociências para a terapia cognitivo-comportamental

    Directory of Open Access Journals (Sweden)

    Patrícia Porto

    2008-12-01

    Full Text Available Os transtornos de ansiedade estão envolvidos com a incapacidade de controlar o medo e a dificuldade em regular emoções negativas. A terapia cognitivo-comportamental (TCC abrange técnicas que permitem tanto a extinção do medo condicionado quanto a regulação cognitiva de emoções. Este artigo tem como objetivo apresentar resultados de estudos de regulação da emoção que podem ilustrar a associação e colaboração entre a TCC e as neurociências. Amparado nas pesquisas de regulação da emoção, este estudo corrobora os resultados dos ensaios clínicos com TCC revelando que as intervenções de distração, reestruturação cognitiva e exposição são eficazes para a regulação emocional.

  17. Criterios para evaluar la eficiencia: hablan psicoterapeutas psicoanalíticos, conductuales cognitivos, racionales emotivos y psicoanalistas

    Directory of Open Access Journals (Sweden)

    Carla Eugenia Mantilla Lagos

    2006-12-01

    Full Text Available El artículo explora los criterios para evaluar la eficiencia de los tratamientos psicoterapéuticos individuales con adultos desde la perspectiva de cuaarenta profesionales representativos de cuatro tipos de intervención clínica: psicoterapias conductual-cognitiva, psicoanalítica y racional-emotiva, y psicoanálisis. Asimismo, busca conocer las similitudes y diferencias entre estos tipos de intervención con respecto a dichos criterios. Para ello, se construyó y aplicó una entrevista semiestructurada que explora las consideraciones acerca de la eficiencia del tratamiento. Del análisis cualitativo de datos, se obtuvieron doce temas de análisis con sus correspondientes categorías de respuesta, los cuales fueron sometidos a un análisis estadístico descriptivo y de correspondencia. Los criterios encontrados son numerosos y variados. Las diferencias halladas entre los cuatro grupos se relacionan con la naturaleza del trabajo terapéutico de cada uno y con el paradigma teórico que los define. Los psicoanalistas y los psicoterapeutas conductuales cognitivos constituyen los grupos que más se diferencian entre sí.

  18. EL ANÁLISIS LITERARIO Y SUS MÉTODOS DESDE UN ENFOQUE COGNITIVO, COMUNICATIVO Y SOCIOCULTURAL

    Directory of Open Access Journals (Sweden)

    Ligia Magdalena Sales Garrido

    2015-03-01

    Full Text Available El artículo se realiza con el objetivo de ofrecer una visión reflexiva sobre algunas de las fundamentales posiciones asumidas en el análisis del texto literario, su aplicación en el plano docente en Cuba, así como las posibilidades que pueden brindar en el enfoque cognitivo, comunicativo y sociocultural, desde la integración de los componentes funcionales comprensión, análisis y construcción. Para ello se realiza un breve acercamiento a las categorías texto, texto artístico, y texto literario, método, análisis y métodos de análisis del texto literario; se reflexiona acerca de los antecedentes y consideraciones sobre algunos métodos de análisis literario y se ofrece un resumen sobre criterios coincidentes para el análisis. Se aborda el análisis literario en la Enseñanza Media en Cuba, teniendo en cuenta los métodos más empleados.

  19. APLICACIÓN ANDROID PARA EL APRENDIZAJE MOTRIZ Y COGNITIVO DE NIÑOS DE EDUCACIÓN INICIAL II

    Directory of Open Access Journals (Sweden)

    Yuri Humberto Merizalde Zamora

    2016-04-01

    Full Text Available El desarrollo de las Tablet y Smartphone ha revolucionado la vida de las personas, el abaratamiento de los costos ha posibilitado que toda familia acceda a estos dispositivos y los niños se familiaricen rápidamente con estos equipos. Las Tablet y los teléfonos inteligentes pueden facilitar el aprendizaje a través de estímulos visuales y auditivos, los mismos que presentados a modo de juego captan el interés de los niños. El objetivo del presente estudio es el diseño de una aplicación educativa para fortalecer el aprendizaje motriz y cognitivo de niños de educación inicial II mediante herramientas de programación para dispositivos móviles con sistema operativo Android, mediante IDE Google Android Studio. La aplicación se podrá instalar mediante un APK o podrá ser descargada directamente desde play store.

  20. A memória cognitivo-discursiva: entre discurso, Psicanálise e cognição

    Directory of Open Access Journals (Sweden)

    Bruno Focas Vieira Machado

    2016-01-01

    Full Text Available Este texto pretende promover um debate interdisciplinar sobre as relações entre os conceitos de sujeito, de discurso e de memória, tal como são encontrados na Análise do Discurso Francesa e na Psicanálise; contrastando-os com as teorizações contemporâneas do campo da cognição social, mais propriamente pelas contribuições trazidas por Sophie Moirand e por Marie-Anne Paveau. Para cumprir esse objetivo, busca-se problematizar o paralelismo cognitivista que a contemporaneidade coloca para ambos os campos, o que culmina na construção de um novo conceito: a memória cognitivo-discursiva. Esse novo conceito é problematizado à luz da Análise do Discurso e da Psicanálise, consolidando uma reflexão sobre os efeitos contemporâneos do cognitivismo e do discurso da ciência em cada um dos campos de saber, assim como sobre a maneira em que ambos podem estabelecer um diálogo.

  1. O modelo de tomasello sobre a evolução cognitivo-linguística humana

    Directory of Open Access Journals (Sweden)

    Sylvio Állan

    Full Text Available O presente trabalho buscou apresentar o modelo de Michael Tomasello sobre a evolução da cognição humana e uma teoria, derivada desse modelo, sobre a aquisição e o desenvolvimento de competências linguístico-simbólicas. Tomasello propõe que a aquisição e o desenvolvimento simbólico dependem de uma cognição cultural exclusivamente humana, mas derivada de adaptações biológicas características da cognição primata. Essas propostas constituem alternativas para as abordagens tradicionais do desenvolvimento cognitivo e linguístico-simbólico humano, uma vez que: (1 destacam aspectos biológicos e culturais como determinantes da cognição humana; (2 consideram as atividades humanas como essencialmente simbólicas; (3 fornecem uma nova concepção de linguagem.

  2. Efeitos de Intervenção Cognitivo-Comportamental sobre Fatores de Risco Psicológicos em Cardiopatas

    Directory of Open Access Journals (Sweden)

    Ricardo Gorayeb

    Full Text Available RESUMODiminuir fatores de risco para cardiopatias pode melhorar a qualidade de vida e reduzir a mortalidade e morbidade relacionadas a elas.O presente estudo avaliou a eficácia de uma intervenção cognitivo-comportamental em grupo sobre ansiedade, depressão, estresse e saúde cardiovascular em cardiopatas. Foram avaliados 91 pacientes antes e após participação nos grupos, com entrevistas semiestruturadas, Inventários Beck (Ansiedade e Depressão e Inventário de Sintomas de Stress para Adultos de Lipp. Coletaram-se medidas fisiológicas para cálculo do escore de Framingham. A participação no grupo resultou em redução dos sintomas de ansiedade, depressão, estresse e melhora do enfrentamento ao estresse. Não houve diferença no escore de Framingham. A intervenção se mostrou eficaz para a redução dos fatores de risco psicológicos nessa amostra.

  3. Análisis de variables psicopedagógicas en hijos adolescentes violentos desde el modelo cognitivo

    Directory of Open Access Journals (Sweden)

    Cristian Molla Esparza

    2018-04-01

    Full Text Available La violencia filio-parental es una realidad latente en nuestra sociedad. El presente artículo analiza la existencia o no de variables psicopedagógicas (académica y laboral como factores de riesgo en hijos adolescentes que ejercen violencia contra sus progenitores. La metodología utilizada es descriptiva, centrada en el análisis de estudios que contemplan estas variables y las comparan con investigaciones sobre hijos agresores. Los resultados sugieren que éstos son factores de riesgo de conductas violentas en adolescentes por violencia filial y esbozan cuestiones relevantes para la investigación, prevención e intervención educativa. Asimismo, desde el modelo cognitivo, se intenta explicar la interacción entre la cognición intrapersonal e impersonal, principalmente, en adolescentes violentos; así como, las habilidades cognitivas vinculadas a la conducta prosocial frente a disposiciones antisociales, con miras a la intervención socioeducativa.

  4. Perfil emocional y cognitivo de la hipertensión arterial esencial mantenida frente a la normotensión

    Directory of Open Access Journals (Sweden)

    Inés Magán Uceda

    2013-01-01

    Full Text Available El objetivo de este estudio ha siso analizar el perfil psicológico de la hipertensión arterial esencial (HTA-E respecto a los siguientes constructos emocionales: ira rasgo, expresión y control de la ira, ansiedad, depre- sión y estrés, incluyéndose como novedad el análisis de los pensamientos automáticos y actitudes disfuncionales relacionadas con la ira-hostilidad. Para ello se comparó un grupo de 57 adultos con HTA-E mantenida con un grupo de 37 adultos con normotensión en diferentes medidas psicométricas de dichos constructos emocionales y cognitivos. Los resultados sugieren que las personas con HTA-E, en comparación a las normotensas, muestran niveles significativamente más elevados de ansiedad y de pensamientos de afrontamiento de la ira-hostilidad así como una tendencia casi significativa a una mayor frecuencia de pensamientos hostiles y físicamente agresivos. Se discuten las implicaciones de estos hallazgos para los modelos psicológicos de la HTA-E y para el diseño o mejora de las intervenciones psicológicas en HTA-E.

  5. Potencial agroindustrial de cáscaras de mango (Mangifera indica variedades Keitt y Tommy Atkins

    Directory of Open Access Journals (Sweden)

    Liliana Serna Cock

    2015-04-01

    Full Text Available En el estudio se evaluó el potencial agroindustrial de las cáscaras de mango de las variedades Keitt y Tommy Atkins, por sus características de rendimientos, contenidos en compuestos fenólicos totales y composición proximal (materia seca, proteína, extracto etéreo, cenizas, fibras dietéticas y energía bruta. Las cáscaras se liofilizaron con el fin de preservar sus compuestos antioxidantes. Se utilizó un diseño unifactorial con dos niveles (variedades y los datos se presentan como media ± desviación estándar (P = 0.05. Con el procesamiento artesanal se produjeron 13.5 ± 0.48% de cáscaras para la variedad Tommy Atkins y 16.1 ± 0.5% para la variedad Keitt, con materia seca de 18 y 17%, respectivamente. Por sus contenidos de materia seca, estos residuos agroindustriales tienen un alto potencial para desarrollar productos de valor agregado. Ambas variedades presentaron cáscara con alto contenido de fibras soluble e insoluble (Keitt 22.1%bs y Tommy Atkins19.9% bs. Se concluye que las cáscaras de mango de estas variedades tienen potencial como ingrediente o suplemento alimentario y en la formulación de alimentos funcionales prebióticos, ya que son una excelente fuente de fibra dietética y de compuestos fenólicos (> 3000 mg/100 g de MS.

  6. POTENCIAL FORRAJERO DE Tithonia diversifolia Hemsl. A Gray EN LA PRODUCCIÓN DE VACAS LECHERAS

    Directory of Open Access Journals (Sweden)

    Luis Alberto Gallego-Castro

    2014-01-01

    Full Text Available Potencial forrajero de Tithonia diversifolia Hemsl. A Gray en la producción de vacas lecheras. El objetivo de este trabajo fue analizar el uso potencial de la Tithonia diversifolia (Hemsl. A. Gray (botón de oro en la alimentación de vacas lecheras en el trópico alto colombiano. Se eligieron términos clave para la búsqueda de información y a partir de ellos se abordaron y analizaron diferentes publicaciones, permitiendo un acercamiento a la problemática propuesta. En estos sistemas de producción típicos del trópico alto en Colombia, el kikuyo (Pennisetum clandestinum contribuye con el mayor aporte en la ración del ganado y debido al alto N, la baja fibra y materia seca, lleva con frecuencia a balances energéticos negativos en las vacas más productivas, por lo que en muchos casos se sostiene la producción con alimento comercial, compuesto principalmente por cereales y con altos niveles de proteína. Las necesidades nutricionales de este tipo de sistemas productivos están orientados a encontrar estrategias que permitan mejorar la oferta forrajera, en términos de variedad y calidad, disminuir la dependencia de alimentos comerciales o al menos facilitar la inclusión de otros que mejoren el desempeño animal. A partir de este análisis, se evidencia el potencial de T. diversifolia en la alimentación de vacas lecheras de alta producción; esta forrajera arbustiva, por su contenido de proteína, carbohidratos solubles y taninos, puede tener un impacto positivo sobre los sistemas de ganadería lechera intensiva y puede incorporarse a suplementos alimenticios.

  7. Método simplificado para determinar el potencial de crecimiento en pacientes de Ortodoncia

    Directory of Open Access Journals (Sweden)

    Gladia Toledo Mayarí

    2010-06-01

    Full Text Available Se realizó una investigación de innovación tecnológica, de corte transversal, con el objetivo de presentar un método simplificado para determinar el potencial de crecimiento en pacientes tributarios de tratamiento ortodóncico, en una muestra de 150 pacientes entre 8 y 16 años, que ingresaron en la Clínica de Ortodoncia de la Facultad de Estomatología de la Habana, entre los años 2004 y 2006. A cada paciente se le realizó una radiografía de la mano izquierda y por primera vez en Cuba se estudiaron en la misma muestra, tres métodos de evaluación del potencial de crecimiento (métodos TW2, Grave y Brown, y determinación de los estadios de maduración de la falange media del tercer dedo. Una vez determinados éstos, se calcularon la correlación y la concordancia entre los mismos. Hubo altos coeficientes de correlación (hembras rho= 0,888 y varones rho= 0,921 y de concordancia (hembras Kappa= 1,000 y varones Kappa= 0,964. Se concluyó que la evaluación del potencial de crecimiento que presentaron los pacientes de Ortodoncia puede ser efectuada mediante la realización de una radiografía de la falange media del tercer dedo de la mano izquierda, lo cual constituye un útil método simplificado de evaluación.

  8. Adding motivational interviewing and thought mapping to cognitive-behavioral group therapy: results from a randomized clinical trial Adicionando a entrevista motivacional e o mapeamento cognitivo à terapia cognitivo-comportamental em grupo: resultados de um ensaio clínico randomizado

    Directory of Open Access Journals (Sweden)

    Elisabeth Meyer

    2010-03-01

    Full Text Available OBJECTIVE: Recent factor-analytic studies of obsessive-compulsive disorder identified consistent symptom dimensions. This study was designed in order to observe which obsessive compulsive symptom dimensions could be changed by adding two individual sessions of motivational interviewing and thought mapping of cognitive-behavioral group therapy using a randomized clinical trial. METHOD: Forty outpatients with a primary diagnosis of obsessive-compulsive disorder were randomly assigned to receive cognitive-behavioral group therapy (control group or motivational interviewing+thought mapping plus cognitive-behavioral group therapy. To evaluate changes in symptomdimensions, the Dimensional Yale-Brown Obsessive-Compulsive Scale was administered at baseline and after treatment. RESULTS: At post-treatment, there were statistically significant differences between cognitive-behavioral group therapy and motivational interviewing+thought mapping+cognitivebehavioral group therapy groups in the mean total Dimensional Yale-Brown Obsessive-Compulsive Scale score, and in the contamination and aggression dimension score. Hoarding showed a statistical trend towards improvement. CONCLUSION: These findings suggest that adding motivational interviewing+thought mapping to cognitive-behavioral group therapy can facilitate changes and bring about a decrease in the scores in different obsessive-compulsive disorder symptom dimensions, as measured by the Dimensional Yale-Brown Obsessive-Compulsive Scale. Nonetheless, additional trials are needed to confirm these results.OBJETIVO: Recentes estudos utilizando análise fatorial no transtorno obsessivocompulsivo identificaram dimensões consistentes dos sintomas. Este estudo foi delineado para observar quais dimensões dos sintomas obsessivo-compulsivos podem ser modificadas adicionando duas sessões individuais de entrevista motivacional e mapeamento cognitivo à terapia cognitivo-comportamental em grupo usando um ensaio cl

  9. Potencial anti-Sporothrix spp. de plantas da família lamiaceae

    OpenAIRE

    Stefanie Bressan Waller

    2015-01-01

    As propriedades terapêuticas das plantas medicinais são cada vez mais estudadas, principalmente devido aos crescentes casos de resistência antimicrobiana, como observado em cepas do Complexo Sporothrix. As plantas da família Lamiaceae são conhecidas por suas propriedades antifúngicas, entretanto, são escassos seus estudos contra agentes causadores da esporotricose. Devido ao potencial promissor dessas plantas, objetivou-se (1) avaliar a atividade anti-Sporothrix spp. in vitro de Origanum vulg...

  10. Evaluación del potencial energético del oleaje en Madagascar

    OpenAIRE

    Araujo Roso, Giovanni

    2017-01-01

    La energía undimotriz, o energía del oleaje, es aquella que aprovecha la energía cinética de la perturbación de la superficie del mar y está considerada como una fuente de gran potencial. Las ventajas de este tipo de recurso respecto a otras energías renovables son variadas: sus eventos son predecibles con detalle, el despliegue de dispositivos tiene un impacto visual inferior a otros y es un recurso inagotable, entre otros. Por otra parte, el campo de la energía del oleaje se ...

  11. Averiguação do potencial de vento em ambiente edificado para aproveitamentos

    OpenAIRE

    Magalhães, Nuno Filipe da Costa

    2011-01-01

    O objectivo deste projecto consiste em analisar o potencial eólico em ambiente edificado urbano, considerando a utilização de turbinas eólicas de eixo vertical para produção de energia nesse contexto. Pretende-se com este documento demonstrar que, embora os estudos sobre as turbinas de eixo vertical sejam ainda reduzidos quando comparados aos das de eixo horizontal, tal não implica que as mesmas não tenham características que, em determinados cenários, sejam superiores às turbinas de eixo hor...

  12. Potencial de aprendizaje y habilidades sociales en escolares con el trastorno de Asperger.

    OpenAIRE

    Bonete Román, Saray

    2010-01-01

    La mayoría de las investigaciones sobre el Trastorno de Asperger (TA) se han centrado en las características definitorias del trastorno mediante procedimientos estandarizados. Sin embargo, se trata de una perspectiva limitada, especialmente en el ámbito de la interacción social. A partir de los resultados positivos obtenidos desde la evaluación del potencial de aprendizaje en otras alteraciones psicológicas, resulta prometedor plantearse aplicaciones similares para el TA. En este estudio se c...

  13. Potencial exportador de los servicios odontológicos en Lima Metropolitana

    OpenAIRE

    Arias Peña, Sonia

    2013-01-01

    Objetivo: Esta investigación determina el potencial de exportación de servicios dentales en Lima (Perú) en el diagnóstico de mercado dental. En concreto, en la investigación se analiza el estado del mercado interno (la oferta), la demanda y la oferta internacional a través de la exploración y la investigación cualitativa descriptiva para el diseño mixto (cualitativo y cuantitativo) de la presente investigación. Método: Se analizó detalladamente la condición de la oferta interna, la demanda in...

  14. Maximização do potencial de enraizamento de estacas de Eucalyptus dunnii Maiden

    OpenAIRE

    Cooper, Marcos Antonio

    2011-01-01

    O potencial de enraizamento de estacas de Eucalyptus dunnii Maiden foi estudado através da realização de cinco experimentos consecutivos. Foram considerados e otimizados os seguintes fatores: variabilidade na capacidade de enraizamento entre 645 matrizes e três procedências: duas épocas do ano; seleção de clones com porcentagem de enraizamento igual ou superior a 50% ; tipos de estacas (diâmetro, número de pares de tolhas e área foliar): concentrações de ácido indol-3-butírico; tipos de subst...

  15. La geografía de los recursos naturales en Cuba: potencial natural y combinaciones territoriales

    OpenAIRE

    Ana María Luna

    1999-01-01

    Este trabajo tiene como objetivo elaborar una imagen geográfica sintetizada de la distribución regional de los recursos naturales en Cuba- Para ello, fue necesario transitar las posturas teórico-metodológicas que abordan este tema de manera unificada. En tal sentido, el cálculo del "potencial natural" y la clasificación de las "combinaciones territoriales de los recursos naturales", posiciones que emergen en la escuela rusa de Geografía, representan los soportes cognoscitivos esenciales de es...

  16. Potencial de cultivo da macroalga Kappaphycus alvarezii no litoral de Santa Catarina

    OpenAIRE

    Santos, Alex Alves dos

    2014-01-01

    Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias, Programa de Pós-Graduação em Aqüicultura, Florianópolis, 2014. Os cultivos da macroalga K. alvarezii em monocultivo ou integrados com moluscos (Crassostrea gigas e Perna perna) podem proporcionar benefícios ambientais e econômicos. Este trabalho avaliou o potencial de cultivo da macroalga Kappaphycus alvarezii no parque aquícola de Santa Catarina. O primeiro trabalho identificou a capacidade do parque e...

  17. Evaluación del golfo de California como una fuente potencial de actinobacterias marinas bioactivas

    OpenAIRE

    Torres-Beltrán, M; Cardoso-Martínez, F; Millán-Aguiñaga, N; Becerril-Espinosa, A; Soria-Mercado, IE

    2012-01-01

    Las actinobacterias son productoras de una gran variedad de compuestos utilizados actualmente como antibióticos y anticancerígenos. En este trabajo se evaluó el potencial del golfo de California como fuente de cepas de actinobacterias bioactivas. En total, se aislaron 235 cepas de actinobacterias de los sedimentos de bahía Concepción y bahía de los Ángeles, (México). Con base en su morfología, requerimiento de agua de mar para su crecimiento y secuenciación del gen 16S del ARNr, las cepas se ...

  18. POSLOVNI POTENCIAL DRUŽBENEGA OMREŽJA INSTAGRAM NA PRIMERU PODJETJA X

    OpenAIRE

    Mujkanović, Maja

    2016-01-01

    V svetu sodobne tehnologije je že skoraj nujno, da podjetja za komuniciranje uporabljajo digitalne medije, saj jim omogočajo lažje približanje ciljni skupini in komuniciranje s svojimi odjemalci. Tako lahko podjetja izbirajo med različnimi družbenimi omrežji, sami pa morajo presoditi, kateri način komuniciranja je najbolj primeren glede na segment njihovih strank. Enega od načinov komuniciranja s strankami omogoča tudi družbeno omrežje Instagram, ki ga bomo kot poslovni potencial v nadalj...

  19. A tactile P300 brain-computer interface

    NARCIS (Netherlands)

    Brouwer, A.M.; Erp, J.B.F. van

    2010-01-01

    De werking van de eerste Brain-Computer-Interface gebaseerd op tactiele EEG response wordt gedemonstreerd en het effect van het aantal gebruikte vibro-tactiele tactoren en stimulus-timing parameters wordt onderzocht

  20. Estudio regional del potencial de secado con aire natural y energía solar

    Directory of Open Access Journals (Sweden)

    Jorge Domínguez P.

    1983-09-01

    Full Text Available En este artículo se presenta y aplica una metodología de trabajo basada en la técnica de simulación matemática y desarrollada con el fin de realizar estudios sobre el potencial de secado de productos agropecuarios con aire natural y energía solar de regiones tropicales. La metodología se basa en el uso de un programa de computador e Incluye otros elementos metodológicos en relación con el manejo de la información meteorológica, el patrón de operación del ventilador, el uso de energía solar y la interpretación de los resultados con el fin de optimizar el sistema. Se reportan los resultados del estudio del potencial de secado con aire natural y energía solar de Tuluá (Valle y se proporcionan recomendaciones específicas para la implementación de sistemas de secado a bala temperatura en la Reglón.

  1. Potencial contaminante del mar por aguas residuales de las industrias de harinas y aceites de pescado

    Directory of Open Access Journals (Sweden)

    Mendiola, Santiago

    1998-02-01

    Full Text Available . In this study we addressed the polluting potential that constitutes the disposal of wastewater from the fish meal and oil Industries Into the sea. With this aim we have analysed some phisico-chemical and bacteriologic aspects of the effluents of these industries, including: weight percentage of organic matter, chemical oxygen load, fatty acids saturation, and presence of Salmonellas. The results suggest a low polluting potential for these effluents, although the acid pH and the high rate of saturation found In fatty acids of oil fishes could imply a certain toxicity for the marine environment.

    En este trabajo se evalúa el potencial contaminante que representa el vertido al mar de los desechos procedentes de las industrias de harinas y aceites de pescado. Para ello se han analizado algunos aspectos de la composición físico-química y bacteriológica de los efluentes residuales de estas industrias, incluyendo entre otros: porcentaje en peso de materia orgánica, demanda química de oxígeno, saturación de ácidos grasos y presencia de Salmonellas. Los resultados muestran en general un bajo potencial contaminante de estas aguas residuales, aunque su pH ácido y el alto grado de saturación encontrado en los ácidos grasos de los aceites de pescado podrían conllevar una cierta toxicidad para el medio marino.

  2. EL POTENCIAL DE LOS ESTUDIOS RETÓRICOS EN LA INVESTIGACIÓN CONTABLE

    Directory of Open Access Journals (Sweden)

    FABIÁN LEONARDO QUINCHE MARTÍN

    2012-01-01

    Full Text Available El presente escrito busca mostrar el papel que ha tenido y potencial que pueden tener los estudios sociales de la ciencia en la investigación contable internacional y nacional. Parte de la percepción de la contabilidad como práctica social constructora de realidades y, al mismo tiempo, legitimadora de órdenes sociales particulares. En especial se hace énfasis en el papel de los estudios retóricos y en la naturaleza retórica de la contabilidad. Se ve a la retórica como todos aquellos dispositivos discursivos que son utilizados por un emisor (individual o colectivo dentro de expresiones textuales, orales o pictóricas a través de las cuales se busca persuadir a un público. A partir de esto se ven los informes contables (internos, externos, entre otros como instrumentos retóricos por los cuales las organizaciones buscan persuadir a diversos 'usuarios' y al mismo tiempo construir su legitimidad. El potencial de la investigación retórica en contabilidad es amplio y de tal amplitud se da cuenta en el texto.

  3. Potencial de secado de yuca con aire natural y energía solar

    Directory of Open Access Journals (Sweden)

    Alfonso Parra Coronado

    1990-01-01

    Full Text Available En este trabajo se presentan los resultados de estudios del potencial de secado de productos agropecuarios con aire natural y energía solar de regiones tropicales, considerando el caso específico de la yuca. La evaluación del potencial de secado de una región se basa en el uso de un programa de computador  Simulación matemática, mediante el cual se obtienen los valores del caudal mínimo de aire requerido para secar el producto antes que éste alcance un nivel de deterioro preestablecido. Otros elementos metodológicos incluyen: manejo de la información meteorológica, mes crítico, patrón de agitación del producto, hora de iniciación del secado, patrón de operación del ventilador, uso de calor suplementario (energía solar e interpretación de los resultados con el fin de optimizar el sistema. Se presentan mapas para Colombia de líneas isocaudales e isoáreas de colector solar plano, con base en los cuales se puede obtener fácilmente la información requerida para el diseño de sistemas de secado de yuca a baja temperatura.

  4. Ambientes Colaborativos Virtuais: potencial das redes sociais. O caso das empresas do Algarve

    Directory of Open Access Journals (Sweden)

    Ana Belo

    2013-12-01

    Full Text Available O objetivo do presente artigo é analisar o potencial das redes sociais no desempenho das pequenas e médias empresas da região do Algarve, tendo sido efectuado um questionário para o efeito. O estudo empírico realizado revela que os dados recolhidos (de 70 empresas possuem boas qualidades psico-métricas. Procedeu-se a uma análise categórica de componentes principais, a qual identificou duas principais tipologias de objectivos nas redes sociais: redes sociais para interacção produto-cliente e pesquisa ou conhecimento; e redes sociais com potencial para o marketing. Uma análise suplementar - análise hierárquica de clusters (com recurso ao método de agrupamento de Ward - identificou três padrões de empresas consoante o seu grau de envolvimento em redes sociais: cluster Social Tec Grau 1; cluster Social Tec Grau 2 e cluster Social Tec Grau 3. Estas análises permitem validar uma metodologia sustentável para este tipo de avaliação.

  5. Potencial evocado miogênico vestibular ocular e cervical simultâneo em indivíduos normais

    OpenAIRE

    Silva,Tatiana Rocha; Resende,Luciana Macedo de; Santos,Marco Aurélio Rocha

    2016-01-01

    RESUMO Objetivo: Caracterizar o registro e analisar os resultados do potencial evocado miogênico vestibular cervical e ocular combinado em indivíduos sem queixas auditivas e vestibulares. Métodos: Participaram da pesquisa 30 indivíduos sem queixa auditiva e com audição dentro dos padrões de normalidade. A coleta de dados foi realizada por meio do potencial evocado miogênico vestibular cervical e ocular registrados simultaneamente. Resultados: Houve diferença entre as orelhas direita e esq...

  6. Potencial de mercado y estructura espacial de los salarios en las regiones españolas, 1955-1995

    OpenAIRE

    Paluzie, Elisenda; Pons Novell, Jordi; Tirado, Daniel A.

    2005-01-01

    En este artículo se examina la relación existente entre los salarios de las regiones españolas y su potencial de mercado en el período 1955-1995. Se prueba la existencia de una estructura espacial de los salarios, en la que los salarios disminuyen al alejarnos de las regiones de renta elevada. Este resultado refuerza la hipótesis de la existencia de una dinámica aglomerativa en España durante la segunda mitad del siglo XX. Sin embargo, el efecto del potencial de mercado sobre los salarios dis...

  7. Análisis del potencial exportador colombiano de carne bovina y porcina a la Federación Rusa

    OpenAIRE

    Bautista Díaz, Camilo Andrés; Rojas Mesa, Camilo Andrés

    2017-01-01

    El estudio del potencial exportador colombiano de carne bovina y porcina a la Federación Rusa en función de su oferta y demanda es un proyecto que pertenece a la línea de realidad dentro del área de investiga