WorldWideScience

Sample records for policy pharmacology resource

  1. Strategic establishment of an International Pharmacology Specialty Laboratory in a resource-limited setting.

    Science.gov (United States)

    Mtisi, Takudzwa J; Maponga, Charles; Monera-Penduka, Tsitsi G; Mudzviti, Tinashe; Chagwena, Dexter; Makita-Chingombe, Faithful; DiFranchesco, Robin; Morse, Gene D

    2018-01-01

    A growing number of drug development studies that include pharmacokinetic evaluations are conducted in regions lacking a specialised pharmacology laboratory. This necessitated the development of an International Pharmacology Specialty Laboratory (IPSL) in Zimbabwe. The aim of this article is to describe the development of an IPSL in Zimbabwe. The IPSL was developed collaboratively by the University of Zimbabwe and the University at Buffalo Center for Integrated Global Biomedical Sciences. Key stages included infrastructure development, establishment of quality management systems and collaborative mentorship in clinical pharmacology study design and chromatographic assay development and validation. Two high performance liquid chromatography instruments were donated by an instrument manufacturer and a contract research organisation. Laboratory space was acquired through association with the Zimbabwe national drug regulatory authority. Operational policies, standard operating procedures and a document control system were established. Scientists and technicians were trained in aspects relevant to IPSL operations. A high-performance liquid chromatography method for nevirapine was developed with the guidance of the Clinical Pharmacology Quality Assurance programme and approved by the assay method review programme. The University of Zimbabwe IPSL is engaged with the United States National Institute of Allergy and Infectious Diseases Division of AIDS research networks and is poised to begin drug assays and pharmacokinetic analyses. An IPSL has been successfully established in a resource-limited setting through the efforts of an external partnership providing technical guidance and motivated internal faculty and staff. Strategic partnerships were beneficial in navigating challenges leading to laboratory development and training new investigators. The IPSL is now engaged in clinical pharmacology research.

  2. Renewable resource policy when distributional impacts matter

    International Nuclear Information System (INIS)

    Horan, R.D.; Shortle, J.S.; Bulte, E.H.

    1999-01-01

    The standard assumption in bioeconomic resource models is that optimal policies maximize the present value of economic surplus to society. This assumption implies that regulatory agencies should not be concerned with the distributional consequences of management strategies. Both contemporary welfare-theoretic and rent-seeking approaches suggests distributional issues are important in designing resource management policies. This paper explores resource management when the managing agency has preferences defined over the economic welfare of various groups with a direct economic interest in the use of resources. Policy schemes consistent with this approach are derived and compared with standard results. 42 refs

  3. Australia modifies resource rent, uranium mining policies

    International Nuclear Information System (INIS)

    Anon.

    1984-01-01

    Current Australian government business and economic policies as they affect the mining industry are discussed. The distribution of constitutional and taxing powers in Australia between state and commonwealth governments and possible inappropriate taxes and other policies can have an adverse effect on resource development. The effects of these policies on both coal and uranium mining are discussed

  4. Human resource policy and Danish multinational companies

    DEFF Research Database (Denmark)

    Fleming, Daniel; Søborg, Henrik

    A study of Danish multinational companies' human resource policy in their subsidiaries in Malaysia and Singapore.The sample of companies consists of 8 Danish multinational companies with activities in both Malaysia and Singapore.......A study of Danish multinational companies' human resource policy in their subsidiaries in Malaysia and Singapore.The sample of companies consists of 8 Danish multinational companies with activities in both Malaysia and Singapore....

  5. Teaching Medical Students Basic Neurotransmitter Pharmacology Using Primary Research Resources

    Science.gov (United States)

    Halliday, Amy C.; Devonshire, Ian M.; Greenfield, Susan A.; Dommett, Eleanor J.

    2010-01-01

    Teaching pharmacology to medical students has long been seen as a challenge, and one to which a number of innovative approaches have been taken. In this article, we describe and evaluate the use of primary research articles in teaching second-year medical students both in terms of the information learned and the use of the papers themselves. We…

  6. Knowledge Systems and Natural Resources: Management, Policy ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2007-10-31

    Oct 31, 2007 ... In recent years, knowledge systems have become a key area of concern for researchers, policy-makers, and development activists. Knowledge Systems and Natural Resources is a unique collection of case studies from Nepal. It provides rich and incisive insights into critical social processes and ...

  7. Systems pharmacology-based drug discovery for marine resources: an example using sea cucumber (Holothurians).

    Science.gov (United States)

    Guo, Yingying; Ding, Yan; Xu, Feifei; Liu, Baoyue; Kou, Zinong; Xiao, Wei; Zhu, Jingbo

    2015-05-13

    Sea cucumber, a kind of marine animal, have long been utilized as tonic and traditional remedies in the Middle East and Asia because of its effectiveness against hypertension, asthma, rheumatism, cuts and burns, impotence, and constipation. In this study, an overall study performed on sea cucumber was used as an example to show drug discovery from marine resource by using systems pharmacology model. The value of marine natural resources has been extensively considered because these resources can be potentially used to treat and prevent human diseases. However, the discovery of drugs from oceans is difficult, because of complex environments in terms of composition and active mechanisms. Thus, a comprehensive systems approach which could discover active constituents and their targets from marine resource, understand the biological basis for their pharmacological properties is necessary. In this study, a feasible pharmacological model based on systems pharmacology was established to investigate marine medicine by incorporating active compound screening, target identification, and network and pathway analysis. As a result, 106 candidate components of sea cucumber and 26 potential targets were identified. Furthermore, the functions of sea cucumber in health improvement and disease treatment were elucidated in a holistic way based on the established compound-target and target-disease networks, and incorporated pathways. This study established a novel strategy that could be used to explore specific active mechanisms and discover new drugs from marine sources. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  8. Beyond America's War on Drugs: Developing Public Policy to Navigate the Prevailing Pharmacological Revolution.

    Science.gov (United States)

    Golub, Andrew; Bennett, Alex S; Elliott, Luther

    2015-03-30

    This paper places America's "war on drugs" in perspective in order to develop a new metaphor for control of drug misuse. A brief and focused history of America's experience with substance use and substance use policy over the past several hundred years provides background and a framework to compare the current Pharmacological Revolution with America's Nineteenth Century Industrial Revolution. The paper concludes with cautions about growing challenges and provides suggestions for navigating this revolution and reducing its negative impact on individuals and society.

  9. Trade policies, institutions and the natural resource curse

    NARCIS (Netherlands)

    Arezki, R.; van der Ploeg, F.

    2010-01-01

    We offer new cross-country evidence on the natural resource curse. We investigate the impact of the interaction of natural resource abundance and policies on growth. We find that the resource curse is less severe in countries with less restrictive trade policies and good institutions. However, we

  10. Beyond America's War on Drugs: Developing Public Policy to Navigate the Prevailing Pharmacological Revolution

    Directory of Open Access Journals (Sweden)

    Andrew Golub

    2015-03-01

    Full Text Available This paper places America's “war on drugs” in perspective in order to develop a new metaphor for control of drug misuse. A brief and focused history of America's experience with substance use and substance use policy over the past several hundred years provides background and a framework to compare the current Pharmacological Revolution with America's Nineteenth Century Industrial Revolution. The paper concludes with cautions about growing challenges and provides suggestions for navigating this revolution and reducing its negative impact on individuals and society.

  11. Resource acquisition policy: Multiple account evaluation of electricity resource alternatives [and] resource acquisition strategy

    International Nuclear Information System (INIS)

    1994-06-01

    British Columbia Hydro has been directed by the provincial government to develop evaluation procedures to rank electricity resource alternatives in terms of their social benefits and costs, and to acquire resources on the basis of need. The current state of development of social costing at BC Hydro is detailed along with its application to the multiple account evaluation of resources. In this evaluation, BC Hydro's corporate costs, customer cost, transfer payments to the province, direct costs incurred by provincial or regional governments or other Crown agences, direct environmental impact costs from air emissions and land/water use, community and social impact costs, and economic development impacts are taken into account. The BC Hydro resource acquisition strategy is also described as it was developed in response to provincial policy on electricity supply from independent power producers. This strategy includes a determination of need, a decision to acquire need-determined resources either by itself or from a private sector developer, and decisions to acquire resources in advance of need for reasons such as economic opportunity, long-term strategies, or load displacement. Background information is included on calculation of air emissions costs. An illustrative example is provided of the multiple account evaluation of several types of resource projects. 1 fig., 5 tabs

  12. Challenges for sustainable resource use : Uncertainty, trade and climate policies

    NARCIS (Netherlands)

    Bretschger, L.; Smulders, Sjak A.

    2012-01-01

    We integrate new challenges to thinking about resource markets and sustainable resource use policies in a general framework. The challenges, emerging from six papers that JEEM publishes in a special issue, are (i) demand uncertainty and stockpiling, (ii) international trade and resource dependence,

  13. Practicing natural resource management with a policy orientation

    Science.gov (United States)

    Clark, Tim W.

    1992-07-01

    All natural resource managers want to contribute to successful conservation programs. Having and applying an explicit policy orientation is indispensable. The policy sciences are described and a case is made that, if natural resource managers utilize this set of conceptual and applied tools in their natural resource work, their effectiveness could be enhanced. The policy sciences offer a contextual, problem-oriented, and multimethod approach to meeting complex problems. Two kinds of knowledge are needed to solve problems—substantive knowledge about the resource and process knowledge about the decision and policy processes used to derive courses of management action. The interplay of science, analysis, and politics are examined. The wildlife management community is used to illustrate many points, including the important role implementation plays in the overall policy process.

  14. Coordinating Policies for Human Resources Development

    OpenAIRE

    G.A. Meagher

    1996-01-01

    In its recent White Paper on Employment and Growth, the Australian Government announced a comprehensive new agenda to supplement its existing employment policies. It includes the following major elements * reforms to labour market assistance; * training and education reforms; * a reconstructed social security system; * a regional strategy; * workplace agreements; and * microeconomic reforms. An important consideration in the implementation of such a multi-faceted policy program is that its va...

  15. Information resources management for policy formulation ...

    African Journals Online (AJOL)

    This article discusses the findings of a study conducted on the state of information resources management (IRM) in government ministries in Tanzania. The purpose of the study was to investigate and establish the extent to which the information resources management in the ministries reflect and support the process of ...

  16. Substitute energy resource policy in Japan

    International Nuclear Information System (INIS)

    Umehara, Katsuhiko

    1980-01-01

    Japan depends 88% of energy resources and 99.8% of petroleum on imports. The solution of energy problems is now made internationally. As the means for Japan, there are the substitution of other resources for petroleum and its promotion. However, this involves the considerable funds for the development and utilization, which must be borne by the people in the form of tax. For governmental financing, a special account must be set up for the particular purpose. In the research and development of new energy resources, new institution is required. The following matters are described: petroleum shortage coming even in 1980s, the international need of substitute energy development, the need for establishing measures for substitute energy resources, acquisition of the funds, special-account governmental financing, and an institute of new energy development. (author)

  17. Energy Policy Case Study - California: Renewables and Distributed Energy Resources

    Energy Technology Data Exchange (ETDEWEB)

    Homer, Juliet S. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Bender, Sadie R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Weimar, Mark R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-09-19

    The purpose of this document is to present a case study of energy policies in California related to power system transformation and renewable and distributed energy resources (DERs). Distributed energy resources represent a broad range of technologies that can significantly impact how much, and when, electricity is demanded from the grid. Key policies and proceedings related to power system transformation and DERs are grouped into the following categories: 1.Policies that support achieving environmental and climate goals 2.Policies that promote deployment of DERs 3.Policies that support reliability and integration of DERs 4.Policies that promote market animation and support customer choice. Major challenges going forward are forecasting and modeling DERs, regulatory and utility business model issues, reliability, valuation and pricing, and data management and sharing.

  18. Situating School District Resource Decision Making in Policy Context

    Science.gov (United States)

    Spain, Angeline K.

    2016-01-01

    Decentralization and deregulation policies assume that local educational leaders make better resource decisions than state policy makers do. Conceptual models drawn from organizational theory, however, offer competing predictions about how district central office administrators are likely to leverage their professional expertise in devolved…

  19. Green Human Resource Management: Policies and practices

    Directory of Open Access Journals (Sweden)

    Shoeb Ahmad

    2015-12-01

    Full Text Available Recently, there has been observed an increasing awareness within business communities on the significance of going green and adopting various environment management techniques. As the corporate world is going global, the business is experiencing a shift from a conventional financial structure to a modern capacity-based economy which is ready to explore green economic facets of business. Today, Green Human Resource Management (GHRM has become a key business strategy for the significant organizations where Human Resource Departments play an active part in going green at the office. The paper largely focuses upon the various Green Human Resource Practices pursued by the organizations all over the world and, explains the simplified meaning of GHRM. The study also adds to the extant literature by discussing future direction of some GHRM functions. Finally, the paper suggests some potentially prolific HR initiatives for Green organizations.

  20. Energy resources in foreign policy: a theoretical approach

    OpenAIRE

    Česnakas, Giedrius

    2010-01-01

    This article examines which theory of international relations is best suited for the analysis of energy resources in international relations. The article suggests that realism paradigm theories might provide a useful starting point from a descriptive method in the studies of energy resources in foreign policy. The idealism paradigm downplays the strategic importance of energy resources, and suggests simplified view that statesmen are economically rational actors. Realism suggests that energy ...

  1. Knowledge Systems and Natural Resources : Management, Policy ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    31 oct. 2007 ... Knowledge Systems and Natural Resources est un recueil unique d'études de cas réalisées au Népal. Cet ouvrage apporte un éclairage ... Un débat d'experts organisé par le CRDI s'attaque au mariage précoce lors du forum sur la condition des femmes à l'ONU. Des chercheurs appuyés par le CRDI ...

  2. A study of weeding policies in eleven TALON resource libraries.

    OpenAIRE

    Goldstein, C H

    1981-01-01

    A study was made of the weeding policies and practices of eleven TALON resource libraries. The results indicated that although weeding, or collection evaluation as it is also known, was performed by most of the libraries, few had a written policy. The reasons for weeding and the types of weeding done by the libraries are described. A discussion of the prevalent means of disposition of withdrawn materials and of the obstacles to cooperative weeding is included.

  3. A study of weeding policies in eleven TALON resource libraries.

    Science.gov (United States)

    Goldstein, C H

    1981-07-01

    A study was made of the weeding policies and practices of eleven TALON resource libraries. The results indicated that although weeding, or collection evaluation as it is also known, was performed by most of the libraries, few had a written policy. The reasons for weeding and the types of weeding done by the libraries are described. A discussion of the prevalent means of disposition of withdrawn materials and of the obstacles to cooperative weeding is included.

  4. A study of weeding policies in eleven TALON resource libraries.

    Science.gov (United States)

    Goldstein, C H

    1981-01-01

    A study was made of the weeding policies and practices of eleven TALON resource libraries. The results indicated that although weeding, or collection evaluation as it is also known, was performed by most of the libraries, few had a written policy. The reasons for weeding and the types of weeding done by the libraries are described. A discussion of the prevalent means of disposition of withdrawn materials and of the obstacles to cooperative weeding is included. PMID:7248594

  5. Sustainable natural resource use in rural China: Trends and policies

    OpenAIRE

    Qu, F.; Kuyvenhoven, A.; Shi, X.; Heerink, N.

    2010-01-01

    In this paper we provide an overview of recent trends in the availability and quality of land and water resources in rural China, and examine the common presumption that rural resources are rapidly degrading in China. Data based on consistent definitions and measurement methods that have recently become available are used to that end. In addition, we analyse the impact of new policy initiatives to introduce market-based instruments and new institutions to address land degradation and water sc...

  6. BOOK REVIEW OPEN EDUCATIONAL RESOURCES: Policy, Costs and Transformation

    Directory of Open Access Journals (Sweden)

    Can GULER

    2016-10-01

    Full Text Available This book presents 15 case studies contributed by researchers and policy makers. The Open Educational Resources (OER implementations are expressed through different point of views. This book focused on three themes: policy, costs and transformation. Policy theme is related to the establishment of priorities for supporting the decisions made by an institution or organization. Costs theme explores the funding of OER, particularly in the sense of cost effectiveness. Transformation theme provides examples that demonstrate how OER can be used in ways that go beyond replication of current teaching and learning models. The editors in the Introduction elaborately describe these three themes.

  7. Quantitative Assessment of Water Resources Adaptation Policies in Mediterranean Europe

    Science.gov (United States)

    Garrote, L. M.; Mediero, L.; Martin-Carrasco, F.

    2011-12-01

    Many factors challenge water management in Southern Europe: scarce water resources, climate change, population growth, environmental concerns and economic development, among others. Water policy in the region is designed to ensure future sustainability of water resources under strong socioeconomic forcing while maintaining the strategic ecological and social services of water. Climate change is projected to intensify these conflicts, since most models agree that Southern Europe will show a significant drying trend, especially during the second half of the century. For this reason, there is a strong need to integrate climate change adaptation into implementation of the EU Water Framework Directive. From the policy perspective, there are many studies on how climate change might lead to changes in hydrologic regime, water demands, water quality or ecosystems, but there little knowledge on how much water demand might be met with future hydrologic regime. In water scarce regions, water demands are supplied by means of hydraulic infrastructure, which performs functions of storage, transportation and distribution, to overcome the spatio-temporal irregularities of hydrologic regime. Knowledge on the relationship between natural water resources, reservoir storage and water demands is essential to assess the effectiveness of alternative policy options to ensure adequate public water supply. In this paper we provide a simple way to account for the influence of socioeconomic factors (hydraulic infrastructure and water policy) on climate change impacts on water resources in the Mediterranean region. We present a methodology to identify and evaluate climate change adaptation policies in this context. The methodology is based on the application of the WAAPA (Water Availability and Adaptation Policy Assessment) model, which computes net water availability for consumptive use for a river basin taking into account the regulation capacity of its water supply system and a set of

  8. Integrating policy, disintegrating practice: water resources management in Botswana

    Science.gov (United States)

    Swatuk, Larry A.; Rahm, Dianne

    Botswana is generally regarded as an African ‘success story’. Nearly four decades of unabated economic growth, multi-party democracy, conservative decision-making and low-levels of corruption have made Botswana the darling of the international donor community. One consequence of rapid and sustained economic development is that water resources use and demands have risen dramatically in a primarily arid/semi-arid environment. Policy makers recognize that supply is limited and that deliberate steps must be taken to manage demand. To this end, and in line with other members of the Southern African Development Community (SADC), Botswana devised a National Water Master Plan (NWMP) and undertook a series of institutional and legal reforms throughout the 1990s so as to make water resources use more equitable, efficient and sustainable. In other words, the stated goal is to work toward Integrated Water Resources Management (IWRM) in both policy and practice. However, policy measures have had limited impact on de facto practice. This paper reflects our efforts to understand the disjuncture between policy and practice. The information presented here combines a review of primary and secondary literatures with key informant interviews. It is our view that a number of constraints-cultural, power political, managerial-combine to hinder efforts toward sustainable forms of water resources use. If IWRM is to be realized in the country, these constraints must be overcome. This, however, is no small task.

  9. Resource Needs for English Learners: Getting Down to Policy Recommendations

    Science.gov (United States)

    Gandara, Patricia; Maxwell-Jolly, Julie; Rumberger, Russell W.

    2008-01-01

    This document is an extension of "Resource Needs for California's English Learners" and is the result of deliberations from several informal meetings and two formal meetings of major stakeholders in the area of English Learner (EL) education. Its intent is to suggest a series of policy options, based on data examined in the initial…

  10. Science, Technology and Natural Resources Policy: Overcoming Congressional Gridlock

    Science.gov (United States)

    McCurdy, K. M.

    2015-12-01

    The current status of Science, Technology and Natural Resources (STNR) policy in the United States provides an ideal context to examine the influence of committee seniority within the public policy process. Exemplars of the Policy Entrepreneur have been individuals in leadership positions, whether executive or legislative. The role of junior committee members in shaping policy innovation is less well understood, and is frequently masked either in cross-sectional research designs or in case studies. The House Natural Resources committee seniority patterns are compared to the House of Representatives Chamber data from 1975 to 2015. This expanse of congressional time captures both the policy innovation of the Class of 1974 who helped transform the public lands by pursuing a preservation agenda, along with the contemporaneous gridlock caused by disagreements about reducing the size of the federal government, a policy agenda championed and sustained by the Class of 1994. Several types of political actors have served as policy entrepreneurs, President Kennedy and Secretary of Interior Udall shepherding the Wilderness Act of 1964 from the Executive branch, or in the 111th Congress Committee chairmen Senator Christopher Dodd and Representative Barney Frank, having announced their retirements, spent their final Congress shaping the consensus that produced the Wall Street Reform and Consumer Protection Act of 2010. A less studied policy phenomenon relies on "packing the committee" to outvote the leadership. This tactic can be used by the party leadership to overcome recalcitrant senior committee members, as was the case for Democrats in the House Interior and Insular Affairs Committee shift to preservation in the 1970s, or the tactic can be employed from the grassroots, as may be happening in the case of the House Natural Resources Committee in the 114th Congress. A policy making process analog to rivers is more appropriate than a mechanistic model. As there are multiple

  11. Adaptive multi-tiered resource allocation policy for microgrids

    Directory of Open Access Journals (Sweden)

    Konstantinos Christidis

    2016-03-01

    Full Text Available We consider a cluster of buildings within proximity that share a large-capacity battery for peak-shaving purposes, and draw power from the grid at a premium once they reach a certain threshold. Our goal is to identify a resource allocation policy that minimizes the amount of energy the cluster draws at a premium, while also ensuring fair access to all of its members. We introduce an adaptive policy that allows for maximum energy savings when the network load is low, and ensures fairness when the aggregate power level is high. We compare this adaptive policy with two standard resource allocation strategies with complementary advantages, and demonstrate through an extensive performance evaluation, that it combines the benefits of both. It is therefore suitable for a microgrid operator where equal weight is given to both cluster-wide cost minimization and fairness among all customers.

  12. Policy tree optimization for adaptive management of water resources systems

    Science.gov (United States)

    Herman, Jonathan; Giuliani, Matteo

    2017-04-01

    Water resources systems must cope with irreducible uncertainty in supply and demand, requiring policy alternatives capable of adapting to a range of possible future scenarios. Recent studies have developed adaptive policies based on "signposts" or "tipping points" that suggest the need of updating the policy. However, there remains a need for a general method to optimize the choice of the signposts to be used and their threshold values. This work contributes a general framework and computational algorithm to design adaptive policies as a tree structure (i.e., a hierarchical set of logical rules) using a simulation-optimization approach based on genetic programming. Given a set of feature variables (e.g., reservoir level, inflow observations, inflow forecasts), the resulting policy defines both the optimal reservoir operations and the conditions under which such operations should be triggered. We demonstrate the approach using Folsom Reservoir (California) as a case study, in which operating policies must balance the risk of both floods and droughts. Numerical results show that the tree-based policies outperform the ones designed via Dynamic Programming. In addition, they display good adaptive capacity to the changing climate, successfully adapting the reservoir operations across a large set of uncertain climate scenarios.

  13. Resource price turbulence and macroeconomic adjustment for a resource exporter. A conceptual framework for policy analysis

    International Nuclear Information System (INIS)

    Cox, Grant M.; Harvie, Charles

    2010-01-01

    Increased global demand for energy and other resources, particularly from the rapidly developing economies of China and India and the opening up of global resource markets to global investors and speculative activity, has resulted in considerable recent turbulence in resource prices. The recent magnitude of change in resource prices, both positive and negative, and their macroeconomic implications is of considerable contemporary importance to both resource importing and exporting economies. For a resource exporting economy, such as that of Australia, the recent resource price boom has resulted in: increased government taxation revenue, increased employment and wages in the resource and resource related sectors, increased spending in the domestic economy that contributed to buoyant economic growth, increased resource exports to the booming economies of China and India and contributed to a stronger domestic currency with beneficial effects upon inflation. On the other hand these developments have had adverse effects on the non-resource sector by: subjecting it to more intense competition for limited resources, contributing to a loss of international competitiveness and reduced exports arising from a stronger exchange rate, reducing employment in the relatively more labour intensive non-resource sector, and contributing to an eventual slow down in the overall economy. These positive and negative effects, and the overall impact of a resource price boom, require a fundamentally closer analysis of the structure of the economy under scrutiny. In this context the policy response by government is likely to be pivotal in determining the overall macroeconomic outcomes from a resource price boom. The aim of this paper is to develop a generic analytical framework to appraise economic outcomes in the wake of a resource price boom for a resource producing and exporting economy. To this end a dynamic long run macroeconomic model is developed, emphasising the important role and

  14. Resource conservation program in terms of Vostokgazprom environmental policy

    Science.gov (United States)

    Tsibulnikova, M. R.; Nadyumov, S. V.; Adam, A. M.; Korotchenko, T. V.

    2016-09-01

    The article examines a number of key areas of environmental policy of Vostokgazprom. The Associated Petroleum Gas program is an important step within the resource conservation and environmental protection framework. In addition, the company undertakes the extensive work on emergency response programs, and carries out continuous protection of the subsurface and control over environmental safety in all production sites. Vostokgazprom continuously modernizes the basic industrial facilities and invests money in new projects. The study analyzes the steps being taken by the company within the energy saving policy that leads to significant costs cut.

  15. Are pharmacological properties of anticoagulants reflected in pharmaceutical pricing and reimbursement policy? Out-patient treatment of venous thromboembolism and utilization of anticoagulants in Poland.

    Science.gov (United States)

    Bochenek, T; Czarnogorski, M; Nizankowski, R; Pilc, A

    2014-06-01

    Pharmacotherapy with vitamin K antagonists (VKA) and low-molecular-weight heparins (LMWH) is a major cost driver in the treatment of venous thromboembolism (VTE). Major representatives of anticoagulants in Europe include: acenocoumarol and warfarin (VKA), enoxaparin, dalteparin, nadroparin, reviparin, parnaparin and bemiparin (LMWH). Aim of this report is to measure and critically assess the utilization of anticoagulants and other resources used in the out-patient treatment of VTE in Poland. To confront the findings with available scientific evidence on pharmacological and clinical properties of anticoagulants. The perspectives of the National Health Fund (NHF) and the patients were adopted, descriptive statistics methods were used. The data were gathered at the NHF and the clinic specialized in treatment of coagulation disorders. Non-pharmacological costs of treatment were for the NHF 1.6 times higher with VKA than with LMWH. Daily cost of pharmacotherapy with LMWH turned out higher than with VKA (234 times for the NHF, 42 times per patient). Within both LMWH and VKA the reimbursement due for the daily doses of a particular medication altered in the manner inversely proportional to the level of patient co-payment. Utilization of long-marketed and cheap VKA was dominated by LMWH, when assessed both through the monetary measures and by the actual volume of sales. Pharmaceutical reimbursement policy favored the more expensive equivalents among VKA and LMWH, whereas in the financial terms the patients were far better off when remaining on a more expensive alternative. The pharmaceutical pricing and reimbursement policy of the state should be more closely related to the pharmacological properties of anticoagulants.

  16. State Electricity Regulatory Policy and Distributed Resources: Distributed Resources and Electric System Reliability

    Energy Technology Data Exchange (ETDEWEB)

    Cowart, R.; Harrington, C.; Moskovitz, D.; Shirley, W.; Weston, F.; Sedano, R.

    2002-10-01

    Designing and implementing credit-based pilot programs for distributed resources distribution is a low-cost, low-risk opportunity to find out how these resources can help defer or avoid costly electric power system (utility grid) distribution upgrades. This report describes implementation options for deaveraged distribution credits and distributed resource development zones. Developing workable programs implementing these policies can dramatically increase the deployment of distributed resources in ways that benefit distributed resource vendors, users, and distribution utilities. This report is one in the State Electricity Regulatory Policy and Distributed Resources series developed under contract to NREL (see Annual Technical Status Report of the Regulatory Assistance Project: September 2000-September 2001, NREL/SR-560-32733). Other titles in this series are: (1) Accommodating Distributed Resources in Wholesale Markets, NREL/SR-560-32497; (2) Distributed Resources and Electric System Re liability, NREL/SR-560-32498; (3) Distribution System Cost Methodologies for Distributed Generation, NREL/SR-560-32500; (4) Distribution System Cost Methodologies for Distributed Generation Appendices, NREL/SR-560-32501.

  17. Virtual Control Policy for Binary Ordered Resources Petri Net Class

    Directory of Open Access Journals (Sweden)

    Carlos A. Rovetto

    2016-08-01

    Full Text Available Prevention and avoidance of deadlocks in sensor networks that use the wormhole routing algorithm is an active research domain. There are diverse control policies that will address this problem being our approach a new method. In this paper we present a virtual control policy for the new specialized Petri net subclass called Binary Ordered Resources Petri Net (BORPN. Essentially, it is an ordinary class constructed from various state machines that share unitary resources in a complex form, which allows branching and joining of processes. The reduced structure of this new class gives advantages that allow analysis of the entire system’s behavior, which is a prohibitive task for large systems because of the complexity and routing algorithms.

  18. Virtual Control Policy for Binary Ordered Resources Petri Net Class.

    Science.gov (United States)

    Rovetto, Carlos A; Concepción, Tomás J; Cano, Elia Esther

    2016-08-18

    Prevention and avoidance of deadlocks in sensor networks that use the wormhole routing algorithm is an active research domain. There are diverse control policies that will address this problem being our approach a new method. In this paper we present a virtual control policy for the new specialized Petri net subclass called Binary Ordered Resources Petri Net (BORPN). Essentially, it is an ordinary class constructed from various state machines that share unitary resources in a complex form, which allows branching and joining of processes. The reduced structure of this new class gives advantages that allow analysis of the entire system's behavior, which is a prohibitive task for large systems because of the complexity and routing algorithms.

  19. Virtual Control Policy for Binary Ordered Resources Petri Net Class

    Science.gov (United States)

    Rovetto, Carlos A.; Concepción, Tomás J.; Cano, Elia Esther

    2016-01-01

    Prevention and avoidance of deadlocks in sensor networks that use the wormhole routing algorithm is an active research domain. There are diverse control policies that will address this problem being our approach a new method. In this paper we present a virtual control policy for the new specialized Petri net subclass called Binary Ordered Resources Petri Net (BORPN). Essentially, it is an ordinary class constructed from various state machines that share unitary resources in a complex form, which allows branching and joining of processes. The reduced structure of this new class gives advantages that allow analysis of the entire system’s behavior, which is a prohibitive task for large systems because of the complexity and routing algorithms. PMID:27548170

  20. The role of common pool resource institutions in the implementation of Swiss natural resource management policy

    Directory of Open Access Journals (Sweden)

    Jean-David Gerber

    2008-07-01

    Full Text Available By analysing Swiss common pool resource (CPR institutions, this paper aims to contribute to the debate on comanagement while demonstrating how important it is to take into account the structuring role played by public policies in the regulation of natural resource use in western countries characterized by significant state intervention. The comparative analysis of three detailed case studies dealing with hunting, flood protection and landscape management policies leads to three main conclusions: (1 CPR institutions strengthen the coherence of resource regimes to the extent that they constitute social institutions which can facilitate the "mediation process," i.e. the transformation of the collective identity, self-perception and, therefore, behaviour of policy target groups in the direction defined by the stated policy objectives; (2 one of the main conditions for the perpetuation of CPR institutions is their capacity to organize their activities around a collective problem defined as such by a policy; (3 the integration of CPR institutions into the political-administrative arrangement contributes to the reinforcement of the functional and territorial coordination between payers, decision makers and beneficiaries in regional and local institutional regimes.

  1. State Electricity Regulatory Policy and Distributed Resources: Accommodating Distributed Resources in Wholesale Markets

    Energy Technology Data Exchange (ETDEWEB)

    Weston, F.; Harrington, C.; Moskovitz, D.; Shirley, W.; Cowart, R.; Sedano, R.

    2002-10-01

    Distributed resources can provide cost-effective reliability and energy services - in many cases, obviating the need for more expensive investments in wires and central station electricity generating facilities. Given the unique features of distributed resources, the challenge facing policymakers today is how to restructure wholesale markets for electricity and related services so as to reveal the full value that distributed resources can provide to the electric power system (utility grid). This report looks at the functions that distributed resources can perform and examines the barriers to them. It then identifies a series of policy and operational approaches to promoting DR in wholesale markets. This report is one in the State Electricity Regulatory Policy and Distributed Resources series developed under contract to NREL (see Annual Technical Status Report of the Regulatory Assistance Project: September 2000-September 2001, NREL/SR-560-32733). Other titles in this series are: (1) Distributed Resource Distribution Credit Pilot Programs - Revealing the Value to Consumers and Vendors, NREL/SR-560-32499; (2) Distributed Resources and Electric System Reliability, NREL/SR-560-32498; (3) Distribution System Cost Methodologies for Distributed Generation, NREL/SR-560-32500; (4) Distribution System Cost Methodologies for Distributed Generation Appendices, NREL/SR-560-32501

  2. Management of Resource Policy: How Mongolia Passes the Test

    Directory of Open Access Journals (Sweden)

    Jiří Mičánek

    2016-01-01

    Full Text Available Mongolia is quickly changing nowadays. This is also thanks to discoveries of enormous mineral wealth. Copper, coal, iron ore and gold in particular are responsible for an amazing growth performance that Mongolia continues to demonstrate over the last decade. As literature demonstrates, large windfalls in natural resources revenues often turn into a curse in the long run, inspiring the term ‘resource curse’. Resource abundant countries are often confronted with negative economic, social and political outcomes. Poor management of resource revenues is often the core of this problem. The article looks at the case of Mongolia. It runs eight tests related to competitiveness, to quality of institutions, to GDP and to growth rate determined by global mineral prices. The results are mixed: tests of institutional quality and volatility of prices has proved the hypothesis, however, the GDP growth and terms of trade tests haven’t shown any negative influence. The results offer a mixed picture (6 tests supporting and 2 tests not-supporting the hypothesis. At this stage, in overall, Mongolia is not yet facing the resource curse. Policy recommendations concern much needed stabilisation of the economy, improvement of institutional quality through legal reforms, and diversification of the economy.

  3. Impact of future energy policy on water resources in Kazakhstan

    Science.gov (United States)

    Rivotti, Pedro; Karatayev, Marat; Sobral Mourão, Zenaida; Shah, Nilay; Clarke, Michèle; Konadu, D. Dennis

    2017-04-01

    As part of its commitment to become one of the top-30 developed countries in the world, Kazakhstan set out an ambitious target of increasing the share of renewables and alternative sources of energy in its power generation mix to 50% by 2050. This vision greatly contrasts with the current situation, with coal and natural gas power plants producing around 90% of total electricity in 2016. While this transition provides a unique opportunity to improve the sustainability of the national energy system, major natural resources challenges currently faced in the country should be taken into account. Particularly in the case of water resources management, the current system is characterised by significant losses, heavy reliance on irrigation for the agricultural sector, unevenly distributed surface water, vulnerability to climate change and variations in transboundary inflows, amongst other issues. In this context, this study aims to investigate the future availability of water resources to support food production and the transition to a new energy system. Given the challenges mentioned above, tackling this question requires an integrated analysis of the water-energy-food systems in Kazakhstan. This is done in three stages: (1) characterising the water supply and demand in the country; (2) establishing the linkages between water resources and activities in the power production and agricultural sectors; and (3) identifying potential conflicts at the nexus between water, energy and food, taking into account future energy policy scenarios, trends for food production and water resource use.

  4. Data Resources for Conducting Health Services and Policy Research.

    Science.gov (United States)

    Blewett, Lynn A; Call, Kathleen Thiede; Turner, Joanna; Hest, Robert

    2018-04-01

    Rich federal data resources provide essential data inputs for monitoring the health and health care of the US population and are essential for conducting health services policy research. The six household surveys we document in this article cover a broad array of health topics, including health insurance coverage (American Community Survey, Current Population Survey), health conditions and behaviors (National Health Interview Survey, Behavioral Risk Factor Surveillance System), health care utilization and spending (Medical Expenditure Panel Survey), and longitudinal data on public program participation (SIPP). New federal activities are linking federal surveys with administrative data to reduce duplication and response burden. In the private sector, vendors are aggregating data from medical records and claims to enhance our understanding of treatment, quality, and outcomes of medical care. Federal agencies must continue to innovate to meet the continuous challenges of scarce resources, pressures for more granular data, and new multimode data collection methodologies.

  5. Western Water Resources: Coming Problems and the Policy Alternatives

    Science.gov (United States)

    Wahl, Richard

    This quote from the book leads one to speculate as to what will happen to water policy in these times of increased concern for reducing federal spending, for more reliance on state and local governments as opposed to the federal government, and for more reliance on the private sector as opposed to any level of governmental control. Remembering that a wrenching debate preceded deregulation of oil and other energy prices, what are the opportunities for deregulation in the water resources field?Western Water Resources consists of the proceedings of a symposium held in Denver in September 1979 and Hosted by the Federal Reserve Bank of Kansas City. As in any conference, there is, in addition to the organized substantive content of the papers, a mixture of the clever and the banal, peppered with some humor and chit-chat. Among the contributors are economists, including Charles Howe, Allen Kneese, Emery Castle, and Kenneth Boulding; legal scholars, such as George Radosevich and Frank Trelease; and political figures, such as Scott Matheson, Governor of Utah, Guy Martin, former Assistant Secretary for Land and Water Resources of the Department of the Interior, and Leo Eisel, former Director of the Water Resources Council. Some papers are followed by a discussion from commentors.

  6. Quantifying exhaustible resource theory: an application to mineral taxation policy

    International Nuclear Information System (INIS)

    Ward, F.A.; Kerkvliet, J.

    1993-01-01

    The paper presents the results of a dynamic nonlinear programming model of a mineral resource market with several features of heterogeneous quality in the mineral, links with related product markets, incorporation of institutional constraints, resource allocations for each year in the planning period, and analysis of outcomes under various severance tax rates. The model computes privately efficient competitive use paths to perform cost-benefit analysis of public mineral policies. Policy variables are evaluated for their impact on both private behaviour and public benefits. The application is to New Mexico's linked coal and electric power markets. Findings reveal that scarcity rents are currently 4% of coal's price, and peak at 27% in 43 years. Increasing the present 1 dollar/ton New Mexico severance tax to 11 dollars reduces current annual coal output by 25%, prolongs the life of the state's coal industry by three years, and increases discounted severance tax revenues by 850% or 4.2 billion dollars. 38 refs., 2 figs., 4 tabs

  7. Plant Resources, 13C-NMR Spectral Characteristic and Pharmacological Activities of Dammarane-Type Triterpenoids

    Directory of Open Access Journals (Sweden)

    Jingya Ruan

    2016-08-01

    Full Text Available Dammarane-type triterpenoids (DTT widely distribute in various medicinal plants. They have generated a great amount of interest in the field of new drug research and development. Generally, DTT are the main bioactive ingredients abundant in Araliaceae plants, such as Panax ginseng, P. japonicas, P. notoginseng, and P. quinquefolium. Aside from Araliaceae, DTT also distribute in other families, including Betulaceae, Cucurbitaceae, Meliaceae, Rhamnaceae, and Scrophulariaceae. Until now, about 136 species belonging to 46 families have been reported to contain DTT. In this article, the genus classifications of plant sources of the botanicals that contain DTT are reviewed, with particular focus on the NMR spectral features and pharmacological activities based on literature reports, which may be benefit for the development of new drugs or food additives.

  8. Evaluation of a filmed clinical scenario as a teaching resource for an introductory pharmacology unit for undergraduate health students: A pilot study.

    Science.gov (United States)

    East, Leah; Hutchinson, Marie

    2015-12-01

    Simulation is frequently being used as a learning and teaching resource for both undergraduate and postgraduate students, however reporting of the effectiveness of simulation particularly within the pharmacology context is scant. The aim of this pilot study was to evaluate a filmed simulated pharmacological clinical scenario as a teaching resource in an undergraduate pharmacological unit. Pilot cross-sectional quantitative survey. An Australian university. 32 undergraduate students completing a healthcare degree including nursing, midwifery, clinical science, health science, naturopathy, and osteopathy. As a part of an undergraduate online pharmacology unit, students were required to watch a filmed simulated pharmacological clinical scenario. To evaluate student learning, a measurement instrument developed from Bloom's cognitive domains (knowledge, comprehension, application, analysis, synthesis and evaluation) was employed to assess pharmacological knowledge conceptualisation and knowledge application within the following fields: medication errors; medication adverse effects; medication interactions; and, general pharmacology. The majority of participants were enrolled in an undergraduate nursing or midwifery programme (72%). Results demonstrated that the majority of nursing and midwifery students (56.52%) found the teaching resource complementary or more useful compared to a lecture although less so compared to a tutorial. Students' self-assessment of learning according to Bloom's cognitive domains indicated that the filmed scenario was a valuable learning tool. Analysis of variance indicated that health science students reported higher levels of learning compared to midwifery and nursing. Students' self-report of the learning benefits of a filmed simulated clinical scenario as a teaching resource suggest enhanced critical thinking skills and knowledge conceptualisation regarding pharmacology, in addition to being useful and complementary to other teaching and

  9. Integrating science, policy and stakeholder perspectives for water resource management

    Science.gov (United States)

    Barbour, Emily; Allan, Andrew; Whitehead, Paul; Salehin, Mashfiqus; Lazzar, Attila; Lim, Michelle; Munsur Rahman, Md.

    2015-04-01

    Successful management of water resources requires an integrated approach considering the complex relationships between different biophysical processes, governance frameworks and socio-economic factors. The Ecosystem Services for Poverty Alleviation (ESPA) Deltas project has developed a range of socio-economic scenarios using a participatory approach, and applied these across different biophysical models as well as an integrated environmental, socio-economic model of the Ganges-Brahmaputra-Meghna (GBM) Delta. This work demonstrates a novel approach through the consideration of multiple ecosystem services and related socio-economic factors in the development of scenarios; the application of these to multiple models at multiple scales; and the participatory approach to improve project outcomes and engage national level stakeholders and policy makers. Scenarios can assist in planning for an uncertain future through exploring plausible alternatives. To adequately assess the potential impacts of future changes and management strategies on water resources, the wider biophysical, socio-economic and governance context needs to be considered. A series of stakeholder workshops have been held in Bangladesh to identify issues of main concern relating to the GBM Delta; to iteratively develop scenario narratives for business as usual, less sustainable, and more sustainable development pathways; and to translate these qualitative scenarios into a quantitative form suitable for analysis. The combined impact of these scenarios and climate change on water quantity and quality within the GBM Basin are demonstrated. Results suggest that climate change is likely to impact on both peak and low flows to a greater extent than most socio-economic changes. However, the diversion of water from the Ganges and Brahmaputra has the potential to significantly impact on water availability in Bangladesh depending on the timing and quantity of diversions. Both climate change and socio

  10. International agreements relating to plant genetic resources for food and agriculture and implications for Dutch policy

    NARCIS (Netherlands)

    Eaton, D.J.F.; Kalaugher, E.; Bijman, J.

    2004-01-01

    Policy issues related to plant genetic resources are socially, technically and scientifically complex. This report summarises the international agreements and relevant bodies con-cerning plant genetic resources for food and agriculture, including the Convention on Biological Diversity (CBD), FAO

  11. A microeconomic perspective on the role of efficiency and equity criteria in designing natural resource policy

    Directory of Open Access Journals (Sweden)

    Geoff Kaine

    2017-03-01

    Full Text Available Deliberating on policy design to manage natural resources with clarity and precision is a difficult task, even for professional and highly experienced policy practitioners. These difficulties are exacerbated by confounding the crafting of policy instruments to change resource use (a behavioral matter related to resource management with the consequential issue of who bears the cost of changing resource use (an equity matter. The confounding of behavioral and equity issues is not surprising because equity is commonly suggested as a criterion in the literature on policy instrument choice, and inequity in access to resources may also be one of the initial drivers of policy intervention. Here, we restate the microeconomic analysis of "open access" resources and highlight the fundamental difference between efficiency (including allocative inefficiency and equity that emerges from that analysis. We then discuss the implications of this difference for the choice of policy instruments to resolve problems in natural resource management, at least for instruments that entail changing the behavior of primary producers. This discussion is centered on three key decisions for formulating policy: (1 choosing the preferred portfolio of uses for a natural resource, (2 choosing a policy instrument to change that portfolio, and (3 choosing a mechanism to distribute the costs of change fairly. To illustrate how these decisions may play out in a real-world example, we apply the decisions to a freshwater policy process in New Zealand. By articulating the distinction, microeconomics draws distinctions between efficiency and equity as policy objectives. Linking that distinction with the Tinbergen's principle regarding the matching of instruments to objectives, we aim to reduce the conflation of the decision-making criteria employed in policy formulation decisions. In doing so, we hope to assist policy makers to avoid policy failure by reducing the potential for the

  12. 48 CFR 1552.211-79 - Compliance with EPA Policies for Information Resources Management.

    Science.gov (United States)

    2010-10-01

    ... Policies for Information Resources Management. 1552.211-79 Section 1552.211-79 Federal Acquisition... Information Resources Management (OCT 2000) (a) Definition. Information Resources Management (IRM) is defined... includes both information itself, and the management of information and related resources such as personnel...

  13. Resource Efficiency. What does it mean and why is it relevant? Policy Brief

    Energy Technology Data Exchange (ETDEWEB)

    Jansen, J.C. [ECN Policy Studies, Petten (Netherlands)

    2013-04-15

    The European Commission has launched a Resource-Efficient Europe as one of its seven flagship initiatives under the Europe 2020 Strategy and has published the document 'Roadmap to a Resource-Efficient Europe'. The Roadmap specifies a proposed pathway to action for a resource efficient Europe. This document sets out to describe the essence of the resource efficiency concept and to sketch the relevance of EU resource efficiency policy for application at EU member state level with special reference to the Netherlands. The following questions will be addressed: What is resource efficiency?; How does it relate to sustainability and environmental footprint?; What is the relevance of EU resource efficiency policy for the member states?; Which aspects of resource efficiency are relevant for the Netherlands?; and To what extent is resource efficiency reflected in current Dutch policies?.

  14. Teaching Social Policy: Integration of Current Legislation and Media Resources

    Science.gov (United States)

    DeRigne, LeaAnne

    2011-01-01

    Social work students enter the field of social work for many reasons--from wanting to become clinicians to wanting to advocate for a more socially just world. Social policy classes can be the ideal courses to provide instruction on conducting research on current policy issues. Teaching students about policy advocacy can lead to a class rich with…

  15. Resource Trends and Population Policy: A Time for Reassessment. Worldwatch Paper 29.

    Science.gov (United States)

    Brown, Lester R.

    Population growth and resource depletion are discussed. The need is stressed for policy makers to understand how population projections relate to the carrying capacity of the earth's basic biological systems. Because the earth's resources are limited, it is essential that policy makers in developed and developing nations be able to analyze the…

  16. Modeling and Recognizing Policy Conflicts with Resource Access Requests on Protected Health Information

    Directory of Open Access Journals (Sweden)

    Raik Kuhlisch

    2017-07-01

    Full Text Available This article discusses potential clashes between different types of security policies that regulate resource access requests on clinical patient data in hospitals by employees. Attribute-based Access Control (ABAC is proposed as a proper means for such regulation. A proper representation of ABAC policies must include a handling of policy attributes among different policy types. In this article, we propose a semantic policy model with predefined policy conflict categories. A conformance verification function detects erroneous, clashing or mutually susceptible rules early during the policy planning phase. The model and conflicts are used in a conceptual application environment and evaluated in a technical experiment during an interoperability test event.

  17. From Waste Management to Resource Efficiency—The Need for Policy Mixes

    Directory of Open Access Journals (Sweden)

    Henning Wilts

    2016-07-01

    Full Text Available Treating waste as a resource and the design of a circular economy have been identified as key approaches for resource efficiency. Despite ambitious targets, policies and instruments that would enable a transition from a conventional waste management to an integrated and comprehensive resource management are still missing. Moreover, this will require innovative policy mixes which do not only address different end-of-pipe approaches but integrate various resource efficiency aspects from product design to patterns of production and consumption. Based on the results of a project funded by the Seventh Framework Programme for Research and Technological Development named “POLFREE—Policy Options for a resource efficient economy”, this paper addresses several aspects of the conceptualization of policy mixes with regard to waste as a specific resource efficiency challenge. The guiding research interest of this paper is the combination of policies necessary to create a full circular economy. In a first step, the present waste policy frameworks, institutions and existing incentives at national level are examined in order to disclose regulatory and policy gaps. Based on this, the second part of the paper describes and analyses specific waste-related resource efficiency instruments with regard to their potential impacts under the constraints of various barriers. Based on the assessment of the country analyses and the innovative instruments, the paper draws conclusions on waste policy mixes and political needs.

  18. Climate policy and nonrenewable resources : The green paradox and beyond

    NARCIS (Netherlands)

    Pittel, Karen; van der Ploeg, Rick; Withagen, Cees

    2014-01-01

    Recent developments suggest that well-intended climate policies–including carbon taxes and subsidies for renewable energy – might not accomplish what policy makers intend. Hans-Werner Sinn has described a "green paradox," arguing that these policies could hasten global warming by encouraging owners

  19. The Role of Paradigm Analysis in the Development of Policies for a Resource Efficient Economy

    Directory of Open Access Journals (Sweden)

    Robin Vanner

    2016-07-01

    Full Text Available Policy makers are often called upon to navigate between scientists’ urgent calls for long-term concerted action to reduce the environmental impacts due to resource use, and the public’s concerns over policies that threaten lifestyles or jobs. Against these political challenges, resource efficiency policy making is often a changeable and even chaotic process, which has fallen short of the political ambitions set by democratically elected governments. This article examines the importance of paradigms in understanding how the public collectively responds to new policy proposals, such as those developed within the project DYNAmic policy MiXes for absolute decoupling of environmental impact of EU resource use from economic growth (DYNAMIX. The resulting proposed approach provides a framework to understand how different concerns and worldviews converge within public discourse, potentially resulting in paradigm change. Thus an alternative perspective on how resource efficiency policy can be development is proposed, which envisages early policies to lay the ground for future far-reaching policies, by altering the underlying paradigm context in which the public receive and respond to policy. The article concludes by arguing that paradigm change is more likely if the policy is conceived, framed, designed, analyzed, presented, and evaluated from the worldview or paradigm pathway that it seeks to create (i.e., the destination paradigm.

  20. Harvesting and replenishment policies for renewable natural resources

    Science.gov (United States)

    Douglas, Aaron J.; Johnson, Richard L.

    1993-01-01

    The current paper links the optimal intertemporal use of renewable natural resources to the harvesting activities of various economic agents. Previous contributions cite market forces as a causative factor inducing the extirpation of renewable natural resources. The analysis given here discusses investment in the stock of renewable resources and cites important examples of this activity. By introducing joint harvesting and replenishment strategies into a model of renewable resource use, the analysis adds descriptive reality and relevance to positive and normative discussions of renewable natural resource use. A high price for the yield or a high discount rate tend to diminish the size of the optimum stationary stock of the resource with a non-replenishment harvesting strategy. Optimal non-replenishment harvesting strategies for renewable natural resources will exhaustion or extirpation of the resource if the price of the yield or the discount rate are sufficiently large. However, the availability of a replenishment technology and the use of replenishment activities tends to buffer the resource against exhaustion or extirpation.

  1. Water Resources Policies and Authorities: Federal Participation in Shore Protection

    National Research Council Canada - National Science Library

    1989-01-01

    This Engineer Regulation (ER) provides policies and guidelines for determining the extent of Federal participation in potential Federal projects for protection from shore erosion, hurricanes, and abnormal tidal and lake flooding...

  2. Definition of Earth Resource Policy and Management Problems in California

    Science.gov (United States)

    Churchman, C. W.; Clark, I.

    1971-01-01

    Management planning for the California water survey considers the use of satellite and airplane remote sensing information on water-source, -center, and -sink geographies. A model is developed for estimating the social benefit of water resource information and to identify the most important types of resource information relevant to regulatory agencies and the private sector.

  3. Seeding Solutions Volume 1: Policy Options for Genetic Resources ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Volume 1 offers policymakers a clear description of the facts, the fights, and the fora relevant to the ownership, conservation, and exchange of genetic resources. ... International Water Resources Association, in close collaboration with IDRC, is holding a webinar titled “Climate change and adaptive water management: ...

  4. Sustainable natural resource use in rural China: Trends and policies

    NARCIS (Netherlands)

    Qu, F.; Kuyvenhoven, A.; Shi, X.; Heerink, N.

    2010-01-01

    In this paper we provide an overview of recent trends in the availability and quality of land and water resources in rural China, and examine the common presumption that rural resources are rapidly degrading in China. Data based on consistent definitions and measurement methods that have recently

  5. Motivation and policies of human resources management in the organization

    Directory of Open Access Journals (Sweden)

    Jovanović Goca

    2017-01-01

    Full Text Available Organizations today operate in an uncertain environment, accompanied by constant change and technological innovation. The greatest impact on performance as the key feature of human resources business. Motivation and employee satisfaction becoming the basis of a modern organization. Motivated employees today represent a strategic resource which confer a competitive advantage of the organization.

  6. Economic transition policies in Chinese resource-based cities: An overview of government efforts

    International Nuclear Information System (INIS)

    Li, Huijuan; Long, Ruyin; Chen, Hong

    2013-01-01

    Resource-based cities in China have made momentous contributions to the development of the national economy for decades. However, with the depletion of natural resources, their sustainable development is challenging and transition is important. The Chinese government has made great efforts to help resource-based cities. The purpose of this study is to investigate transition policies and their implementation. Firstly, we reviewed previous studies and summarized the essential elements of some successful resource-based cities, which are useful experiences for Chinese resource-based cities. Secondly, we studied the development of resource-based cities over the past 10 years with a focus on economic development, industrial structure, government revenue and environmental conditions. We found that resource-based cities were less developed compared to other cities. The main reasons are the after-effects of a planned economy, an unreasonable tax system, planning mistakes and misguided resources exploitation policies. Thirdly, we analyzed several aspects of the policy responses after the introduction of transition policies, including designating 69 resource-exhausted cities, supporting cities with funds and projects, formulating transition plans and evaluating transition performance. However, there are some deficiencies in the process of policy implementation. Finally, some recommendations were provided to improve transition performance and sustainable development for resource-based cities. - Highlights: ► Analyze the development of Chinese resource-based cities from four aspects. ► Analyze the causes of less development in resource-based cities. ► Investigate policies and their responses to transformation. ► Provide recommendations to improve transformation performance and sustainable development

  7. 33 CFR 157.415 - Bridge resource management policy and procedures.

    Science.gov (United States)

    2010-07-01

    ... HOMELAND SECURITY (CONTINUED) POLLUTION RULES FOR THE PROTECTION OF THE MARINE ENVIRONMENT RELATING TO TANK... Petroleum Oils § 157.415 Bridge resource management policy and procedures. (a) Not later than February 1...

  8. Second best pricing policies for an exhaustible resource

    Energy Technology Data Exchange (ETDEWEB)

    Hanson, D.A.

    1977-02-01

    In the theory of exhaustible resources, the classical result, originally derived by Harold Hotelling (J. Polit. Econ., 39: 137-75 (1931)) is that the scarcity rent of the resource must increase at the rate of interest. The scarcity rent is the market price of the resource less extraction costs. At the depletion time, the market price must be equal either to the zero demand price or the cost of a perfect substitute, assuming no adjustment costs in switching to the substitute. The substitute may be either a natural resource with a higher extraction cost or a backstop technology. The Hotelling result is a price equilibrium condition in a competitive asset market (Solow, Amer. Econ. Rev. Proc., 64: 1-14 (1974)). It is also an efficiency condition for allocating the resource over time in a first best world. However, Solow raises the possibility that constraints creating a wedge between interest rates may be important considerations in the resource allocation problem. In a second-best world it is not at all clear how fast the scarcity rent of the resource should increase from a social viewpoint. However, for one simple case the analysis of this problem is straightforward. Suppose consumption is determined by a Keynesian consumption function with marginal propensity to consume (1 - s); s is marginal propensity to save. With consumption determined in this behavioral manner, savings may be inadequate to reduce the market interest rate to the point where it is equal to the social rate of time preference. It is argued here that for this case the scarcity rent of the resource should increase at a rate equal to a weighted combination of these two interest rates.

  9. Human resources policy in the public management: problems and search for their solution

    OpenAIRE

    Natalia Ivanova; O. Vasilyev

    2011-01-01

    The article is devoted to the formation of a human resources policy in the public administration: trends of its development, problems and principles of its implementation. Th e article focuses on the formation of the civic and professional identity in public service workers. Experience of Vologda public administration and municipal management bodies is a good example of a successful implementation of the human resources policy. Th ey could fi nd some eff ective ways of solving problems which ...

  10. In the Arid Zone: Drying out Educational Resources for English Language Learners through Policy and Practice

    Science.gov (United States)

    DaSilva Iddings, Ana Christina; Combs, Mary Carol; Moll, Luis

    2012-01-01

    This article presents a variety of issues related to the effects of restrictive language and educational policies that ultimately limits important resources for English language learners (i.e., services, funding, time, and information). The authors spotlight the state of Arizona as an unfortunate case of language control through policies, which…

  11. Integrating science and policy in natural resource management: lessons and opportunities from North America.

    Science.gov (United States)

    Roger N. Clark; Errol E. Meidinger

    1998-01-01

    Relations between science and policy concerning many issues (e.g., health, energy, natural resources) have been changing worldwide. Public pressure to resolve such complex and often controversial issues has resulted in policymakers and policy implementers seeking better knowledge on which to base their decisions. As a result, scientists have become more actively...

  12. Definition of Earth Resources Policy and Management Problems in California

    Science.gov (United States)

    Churchman, C. W.

    1972-01-01

    The activities of the Social Sciences Group in solving earth resources management problems as related to social factors, are reported. Major efforts of the Group revolved around identifying potential users of ERTS data, ascertain the user's needs, and assay the organizational impacts of new and technologically advanced sources of information. Attempts were also made to develop a linear programming model to be used in decision making with respect to resources being observed by ERTS and other remote sensing vehicles. The cost effectiveness of solving these management problems is discussed.

  13. Public health human resources: a comparative analysis of policy documents in two Canadian provinces

    Science.gov (United States)

    2014-01-01

    Background Amidst concerns regarding the capacity of the public health system to respond rapidly and appropriately to threats such as pandemics and terrorism, along with changing population health needs, governments have focused on strengthening public health systems. A key factor in a robust public health system is its workforce. As part of a nationally funded study of public health renewal in Canada, a policy analysis was conducted to compare public health human resources-relevant documents in two Canadian provinces, British Columbia (BC) and Ontario (ON), as they each implement public health renewal activities. Methods A content analysis of policy and planning documents from government and public health-related organizations was conducted by a research team comprised of academics and government decision-makers. Documents published between 2003 and 2011 were accessed (BC = 27; ON = 20); documents were either publicly available or internal to government and excerpted with permission. Documentary texts were deductively coded using a coding template developed by the researchers based on key health human resources concepts derived from two national policy documents. Results Documents in both provinces highlighted the importance of public health human resources planning and policies; this was particularly evident in early post-SARS documents. Key thematic areas of public health human resources identified were: education, training, and competencies; capacity; supply; intersectoral collaboration; leadership; public health planning context; and priority populations. Policy documents in both provinces discussed the importance of an educated, competent public health workforce with the appropriate skills and competencies for the effective and efficient delivery of public health services. Conclusion This policy analysis identified progressive work on public health human resources policy and planning with early documents providing an inventory of issues to be

  14. Challenges and contradictions in Nigeria's water resources policy ...

    African Journals Online (AJOL)

    But considering the underdeveloped status of Nigeria, there are three critical sectors whose effective functionalities are synergistic for accomplishing the RBDAs ... Work should continue on the comprehensive Water Resources Bill through the process of consultation that promote inclusion, accountability, transparency, and ...

  15. Negotiating Social Policies in Kenya: Aid, Ethnicity and Resource Struggles

    NARCIS (Netherlands)

    M.S. Cifuentes Montoya (Mariana)

    2012-01-01

    textabstractSince independence, the Kenyan state claims to have pursued the principle of equal rights as an important part of its nation-building project. At the same time, Kenya’s population is differentiated economically and politically along ethnic lines with state resources benefiting mainly

  16. Policy Networks and Forest Resource Management in Ghana | Teye ...

    African Journals Online (AJOL)

    Ghana Journal of Geography ... While resource constraints have often been used by slate forestry officials to justif; inability to control deforestation, the paper concludes that the problem is also compounded by the pervasiveness of patronage relationships between and among forestry officials, timber contractors, illegal ...

  17. Funds from non-renewable energy resources: Policy lessons from Alaska and Alberta

    International Nuclear Information System (INIS)

    Baena, César; Sévi, Benoît; Warrack, Allan

    2012-01-01

    We document the use of energy natural resource funds in Alaska and Alberta and analyze theirs characteristics for further implementation in resource-rich countries. Such funds allow dealing theoretically with intergenerational equity issues, corruption, and more general institutional problems. The performance of both funds is very different, depending on the management and composition choices but some policy lessons can be drawn from these two examples. Importantly, the role of a public dividend policy is highlighted as a way to bypass corrupted institutions and to enhance quality of life for poorest people. We also emphasize the need to deal with inflation to make the fund sustainable. - Highlights: ► We document the optimal intergenerational energy resource management using funds. ► We use Alaskan and Albertan experiences to provide policy lessons for future implementation of such funds. ► We emphasize the role of a public dividend policy

  18. Bridging Water Resources Policy and Environmental Engineering in the Classroom at Cornell University

    Science.gov (United States)

    Walter, M. T.; Shaw, S. B.; Seifert, S.; Schwarz, T.

    2006-12-01

    Current university undergraduate students in environmental sciences and engineering are the next generation of environmental protection practitioners. Recognizing this, Cornell's Biological and Environmental Engineering department has developed a popular class, Watershed Engineering (BEE 473), specifically designed to bridge the too-common gap between water resources policy and state-of-art science and technology. Weekly homework assignments are to design real-life solutions to actual water resources problems, often with the objective of applying storm water policies to local situations. Where appropriate, usually in conjunction with recent amendments to the Federal Clean Water Act, this course introduces water resource protection tools and concepts developed in the Cornell Soil and Water Lab. Here we present several examples of how we build bridges between university classrooms and the complex world of water resources policy.

  19. The Oregon health insurance experiment: when limited policy resources provide research opportunities.

    Science.gov (United States)

    Allen, Heidi; Baicker, Katherine; Taubman, Sarah; Wright, Bill; Finkelstein, Amy

    2013-12-01

    In 2008 Oregon allocated access to its Medicaid expansion program, Oregon Health Plan Standard, by drawing names from a waiting list by lottery. The lottery was chosen by policy makers and stakeholders as the preferred way to allocate limited resources. At the same time, it also gave rise to the Oregon Health Insurance Experiment: an unprecedented opportunity to do a randomized evaluation - the gold standard in medical and scientific research - of the impact of expanding Medicaid. In this article we provide historical context for Oregon's decision to conduct a lottery, discuss the importance of randomized controlled designs for policy evaluation, and describe some of the practical challenges in successfully capitalizing on the research opportunity presented by the Oregon lottery through public-academic partnerships. Since policy makers will always face tough choices about how to distribute scarce resources, we urge thoughtful consideration of the opportunities to incorporate randomization that can substantially improve the evidence available to inform policy decisions without compromising policy goals.

  20. Integrated assessment, water resources, and science-policy communication

    International Nuclear Information System (INIS)

    Davies, E.G.R.; Akhtar, M.K.; McBean, G.A.; Simonovic, S.P.

    2009-01-01

    Traditional climate change modeling neglects the role of feedbacks between different components of society-biosphere-climate system. Yet, such interconnections are critical. This paper describes an alternative, Integrated Assessment (IA) model that focuses on feedbacks not only within individual elements of the society-biosphere-climate system, but also on their interconnections. The model replicates the relevant dynamics of nine components of the society-biosphere- climate system at the sectoral, or single-component, level: climate, carbon cycle, hydrological cycle, water demand, water quality, population, land use, energy and economy. The paper discusses the role of the model in science-policy dialogue. (author)

  1. What shapes research impact on policy? Understanding research uptake in sexual and reproductive health policy processes in resource poor contexts.

    Science.gov (United States)

    Sumner, Andy; Crichton, Jo; Theobald, Sally; Zulu, Eliya; Parkhurst, Justin

    2011-06-16

    Assessing the impact that research evidence has on policy is complex. It involves consideration of conceptual issues of what determines research impact and policy change. There are also a range of methodological issues relating to the question of attribution and the counter-factual. The dynamics of SRH, HIV and AIDS, like many policy arenas, are partly generic and partly issue- and context-specific. Against this background, this article reviews some of the main conceptualisations of research impact on policy, including generic determinants of research impact identified across a range of settings, as well as the specificities of SRH in particular. We find that there is scope for greater cross-fertilisation of concepts, models and experiences between public health researchers and political scientists working in international development and research impact evaluation. We identify aspects of the policy landscape and drivers of policy change commonly occurring across multiple sectors and studies to create a framework that researchers can use to examine the influences on research uptake in specific settings, in order to guide attempts to ensure uptake of their findings. This framework has the advantage that distinguishes between pre-existing factors influencing uptake and the ways in which researchers can actively influence the policy landscape and promote research uptake through their policy engagement actions and strategies. We apply this framework to examples from the case study papers in this supplement, with specific discussion about the dynamics of SRH policy processes in resource poor contexts. We conclude by highlighting the need for continued multi-sectoral work on understanding and measuring research uptake and for prospective approaches to receive greater attention from policy analysts.

  2. SHRIMP MARICULTURE DEVELOPMENT IN ECUADOR: SOME RESOURCE POLICY ISSUES

    OpenAIRE

    Southgate, Douglas

    1992-01-01

    During the past 15 years, Ecuador has become the Western Hemisphere's leading producer and exporter of shrimp. Growth has come about largely through mariculture development. About 8,000 metric tons (MT) of shrimp have been captured off the Ecuadorian coast each year since the late 1970s. Meanwhile, pond output has increased several-fold, from less than 5,000 MT in 1979 to over 100,000 MT 12 years later (Table 1). Mariculture has expanded largely at the expense of renewable natural resources. ...

  3. Using Scenarios to Assess Policy Mixes for Resource Efficiency and Eco-Innovation in Different Fiscal Policy Frameworks

    Directory of Open Access Journals (Sweden)

    Laurent Bontoux

    2016-03-01

    Full Text Available There is no longer any doubt that the European Union needs to manage a transition towards a sustainable economy and society. The complexity of such an enterprise is creating major challenges that require a future oriented systemic approach, looking at the EU economy and society as a whole, and going beyond current agendas and policies. The purpose of the JRC foresight study “2035: Paths towards a sustainable EU economy” was to explore how this could be possible. Resource efficiency was at the core of the reflection. This created a context where the fiscal framework was perceived by the experts involved as essential in driving (or hindering the evolution towards a more sustainable future. Societal values (individualistic or collaborative were selected as the other axis around which to construct four scenarios. A large number of other drivers of change were taken into account to construct scenarios of a sufficient depth and detail to generate a systemic understanding. The scenarios were used in an original way to help experts identify which policy mixes would be best adapted to push each scenario towards a more sustainable future, while respecting its own logic and constraints. For each scenario, 6 policy domains considered the most relevant were selected among more than 50. Research and innovation, new business models and education were considered important for all four scenarios. The other domains were natural resources management, regulation, ethics, employment, transparency, governance, social protection, and systems integration. The study illustrates how powerful a policy framework which is fiscally supportive of environmental sustainability can be in supporting resource efficiency and that this can be achieved in very different ways depending on the prevailing social values. It also shows how a combination of actions in other policy areas can be used to drive sustainability further. In sum, this work illustrates how the creative use of

  4. Clinical Policy Recommendations from the VHA State-of-the-Art Conference on Non-Pharmacological Approaches to Chronic Musculoskeletal Pain.

    Science.gov (United States)

    Kligler, Benjamin; Bair, Matthew J; Banerjea, Ranjana; DeBar, Lynn; Ezeji-Okoye, Stephen; Lisi, Anthony; Murphy, Jennifer L; Sandbrink, Friedhelm; Cherkin, Daniel C

    2018-05-01

    As a large national healthcare system, Veterans Health Administration (VHA) is ideally suited to build on its work to date and develop a safe, evidence-based, and comprehensive approach to the care of chronic musculoskeletal pain conditions that de-emphasizes opioid use and emphasizes non-pharmacological strategies. The VHA Office of Health Services Research and Development (HSR&D) held a state-of-the-art (SOTA) conference titled "Non-pharmacological Approaches to Chronic Musculoskeletal Pain Management" in November 2016. Goals of the conference were (1) to establish consensus on the current state of evidence regarding non-pharmacological approaches to chronic musculoskeletal pain to inform VHA policy in this area and (2) to begin to identify priorities for the future VHA research agenda. Workgroups were established and asked to reach consensus recommendations on clinical and research priorities for the following treatment strategies: psychological/behavioral therapies, exercise/movement therapies, manual therapies, and models for delivering multimodal pain care. Participants in the SOTA identified nine non-pharmacological therapies with sufficient evidence to be implemented across the VHA system as part of pain care. Participants further recommended that effective integration of these non-pharmacological approaches across the VHA and especially into VHA primary care, pain care, and mental health settings should be a priority, and that these treatments should be offered early in the course of pain treatment and delivered in a team-based, multimodal treatment setting concurrently with active self-care and self-management approaches. In addition, we recommend that VHA leadership and policy makers systematically address the barriers to implementation of these approaches by expanding opportunities for clinician and veteran education on the effectiveness of these strategies; supporting and funding further research to determine optimal dosage, duration, sequencing

  5. Citizen science and natural resource governance: program design for vernal pool policy innovation

    Directory of Open Access Journals (Sweden)

    Bridie McGreavy

    2016-06-01

    Full Text Available Effective natural resource policy depends on knowing what is needed to sustain a resource and building the capacity to identify, develop, and implement flexible policies. This retrospective case study applies resilience concepts to a 16-year citizen science program and vernal pool regulatory development process in Maine, USA. We describe how citizen science improved adaptive capacities for innovative and effective policies to regulate vernal pools. We identified two core program elements that allowed people to act within narrow windows of opportunity for policy transformation, including (1 the simultaneous generation of useful, credible scientific knowledge and construction of networks among diverse institutions, and (2 the formation of diverse leadership that promoted individual and collective abilities to identify problems and propose policy solutions. If citizen science program leaders want to promote social-ecological systems resilience and natural resource policies as outcomes, we recommend they create a system for internal project evaluation, publish scientific studies using citizen science data, pursue resources for program sustainability, and plan for leadership diversity and informal networks to foster adaptive governance.

  6. Resources

    Science.gov (United States)

    ... Colon cancer - resources Cystic fibrosis - resources Depression - resources Diabetes - resources Digestive disease - resources Drug abuse - resources Eating disorders - resources Elder care - resources Epilepsy - resources Family ...

  7. National forecast for geothermal resource exploration and development with techniques for policy analysis and resource assessment

    Energy Technology Data Exchange (ETDEWEB)

    Cassel, T.A.V.; Shimamoto, G.T.; Amundsen, C.B.; Blair, P.D.; Finan, W.F.; Smith, M.R.; Edeistein, R.H.

    1982-03-31

    The backgrund, structure and use of modern forecasting methods for estimating the future development of geothermal energy in the United States are documented. The forecasting instrument may be divided into two sequential submodels. The first predicts the timing and quality of future geothermal resource discoveries from an underlying resource base. This resource base represents an expansion of the widely-publicized USGS Circular 790. The second submodel forecasts the rate and extent of utilization of geothermal resource discoveries. It is based on the joint investment behavior of resource developers and potential users as statistically determined from extensive industry interviews. It is concluded that geothermal resource development, especially for electric power development, will play an increasingly significant role in meeting US energy demands over the next 2 decades. Depending on the extent of R and D achievements in related areas of geosciences and technology, expected geothermal power development will reach between 7700 and 17300 Mwe by the year 2000. This represents between 8 and 18% of the expected electric energy demand (GWh) in western and northwestern states.

  8. Advocacy coalitions involved in California's menu labeling policy debate: Exploring coalition structure, policy beliefs, resources, and strategies.

    Science.gov (United States)

    Payán, Denise D; Lewis, LaVonna B; Cousineau, Michael R; Nichol, Michael B

    2017-03-01

    Advocacy coalitions often play an important role in the state health policymaking process, yet little is known about their structure, composition, and behavior. In 2008, California became the first state to enact a menu labeling law. Using the advocacy coalition framework, we examine different facets of the coalitions involved in California's menu labeling policy debate. We use a qualitative research approach to identify coalition members and explore their expressed beliefs and policy arguments, resources, and strategies by analyzing legislative documents (n = 87) and newspaper articles (n = 78) produced between 1999 and 2009. Between 2003 and 2008, six menu labeling bills were introduced in the state's legislature. We found the issue received increasing media attention during this period. We identified two advocacy coalitions involved in the debate-a public health (PH) coalition and an industry coalition. State organizations acted as coalition leaders and participated for a longer duration than elected officials. The structure and composition of each coalition varied. PH coalition leadership and membership notably increased compared to the industry coalition. The PH coalition, led by nonprofit PH and health organizations, promoted a clear and consistent message around informed decision making. The industry coalition, led by a state restaurant association, responded with cost and implementation arguments. Each coalition used various resources and strategies to advance desired outcomes. PH coalition leaders were particularly effective at using resources and employing advocacy strategies, which included engaging state legislators as coalition members, using public opinion polls and information, and leveraging media resources to garner support. Policy precedence and a local policy push emerged as important policymaking strategies. Areas for future research on the state health policymaking process are discussed. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. [Laboral health in Penitentiary Center of Chile: a look from policies of human resources].

    Science.gov (United States)

    Güilgüiruca R, M; Herrera-Bascur, J

    2015-01-01

    This article examines the influence of human resources policies on occupational health variables, such as engagement and job satisfaction, with regard to Chilean prison employees. 80 workers at the Women's Prison of Iquique were evaluated and results show that 77% and 88 % have a moderate to high score in terms of engagement and job satisfaction respectively. The 24% variation in engagement of the workers studied can be explained by policies aimed at promoting personal interests, while 32% of the variation in job satisfaction could be explained by policies of self-efficacy and personal interests. The above data permits the assertion to be made that human resources policies have a role that is relevant and necessary to modify and improve the occupational health conditions of these public sector workers.

  10. Policies of natural Resources Management and Environmental Economic Advantages - Attractions in Kosovo

    Directory of Open Access Journals (Sweden)

    Afrim Selimaj

    2015-11-01

    Full Text Available Ecosystem management is a recent alternative policy proposed by the Kosovo government to address a new generation of environmental issues. All Kosovo agency managements are currently exploring the concept of ecosystem management and their implications. Their activities are focused in the management of land and natural resources, by developing policy guidelines regarding the management of the ecosystem and the efforts undertaken that are only one layer of a larger phenomenon nationwide. Similar activities occur at the state and local levels, as well as within the NGO sector. In this sense, this paper addresses two questions: What is the policy of ecosystem management? Would Ecosystem management remain only a land management policy and resource?

  11. Discharge Fee Policy Analysis: A Computable General Equilibrium (CGE) Model of Water Resources and Water Environments

    OpenAIRE

    Guohua Fang; Ting Wang; Xinyi Si; Xin Wen; Yu Liu

    2016-01-01

    To alleviate increasingly serious water pollution and shortages in developing countries, various kinds of policies have been implemented by local governments. It is vital to quantify and evaluate the performance and potential economic impacts of these policies. This study develops a Computable General Equilibrium (CGE) model to simulate the regional economic and environmental effects of discharge fees. Firstly, water resources and water environment factors are separated from the input and out...

  12. Resources from the workshop "Data for invasive species research, policy making and management"

    OpenAIRE

    Quentin Groom; Tim Adriaens; Peter Desmet; Aaike De Wever; Sonia Vanderhoeven

    2017-01-01

    Materials from a workshop titled "Data for invasive species research, policy making and management" held in Brussels on 16-17 February 2016 at the Belgian Science Policy Office (BelSPO). The collection of materials including a list of the nomenclatural and taxonomic resources given by delegates at the workshop. Discussion templeates used at the workshop, a group photo and pictures of the discussion summaries.

  13. Polarization reversal, migration related shifts in human resource profiles, and spatial growth policies: a Venezuelan study.

    Science.gov (United States)

    Brown, L A; Lawson, V A

    1989-01-01

    "This article examines polarization reversal in terms of changing human resource profiles related to migration and to national policies affecting the spatial pattern of economic growth. It first demonstrates the relationship between these elements through a review that integrates three distinct themes in earlier research. Attention then turns to an empirical study of human resource variation among eight urban districts and the rest of Venezuela treated as a single unit. This comparison utilizes age, gender, educational attainment, and occupational status variables provided by individual records of Venezuela's 1971 Population Census. A concluding section relates empirical findings to policy alternatives." excerpt

  14. Comparative study of water resource management policies between China and Denmark

    DEFF Research Database (Denmark)

    Su, Liya; Christensen, Per; Liu, Jingling

    2013-01-01

    This paper compares water resource policies and management practices in China and Denmark. It takes two vulnerable water ecosystems as case studies: Baiyangdian wetland in China and Mariager fjord in Denmark. Based on the theories of the commons, this article explores the similarities...... due to the complicated administrative structure in China and clearer goals and better resources in Denmark. Denmark has also accomplished a large degree of environmental policy integration (EPI), which is not the case in China. But China has recently put environmental concerns high on the agenda...

  15. Does the EU meet its policy objective of 'promoting sustainable use of arctic resources'? An analysis from the viewpoint of arctic energy resources

    NARCIS (Netherlands)

    Neumann, A.; Hossain, Kamrul

    2014-01-01

    The EU started to develop its own Arctic policy in 2008. One of the three main objectives of this policy is the promotion of sustainable use of Arctic resources. "Sustainability" was also a focus of the 2011 resolution of the European Parliament as a guiding principle in developing European policies

  16. State Electricity Regulatory Policy and Distributed Resources: Distribution System Cost Methodologies for Distributed Generation; Appendices

    Energy Technology Data Exchange (ETDEWEB)

    Shirley, W.; Cowart, R.; Sedano, R.; Weston, F.; Harrington, C.; Moskovitz, D.

    2002-10-01

    Designing and implementing credit-based pilot programs for distributed resources distribution is a low-cost, low-risk opportunity to find out how these resources can help defer or avoid costly electric power system (utility grid) distribution upgrades. This report describes implementation options for deaveraged distribution credits and distributed resource development zones. Developing workable programs implementing these policies can dramatically increase the deployment of distributed resources in ways that benefit distributed resource vendors, users, and distribution utilities. This report is one in the State Electricity Regulatory Policy and Distributed Resources series developed under contract to NREL (see Annual Technical Status Report of the Regulatory Assistance Project: September 2000-September 2001, NREL/SR-560-32733). Other titles in this series are: (1) Accommodating Distributed Resources in Wholesale Markets, NREL/SR-560-32497; (2) Distributed Resources and Electric System Re liability, NREL/SR-560-32498; (3) Distribution System Cost Methodologies for Distributed Generation, NREL/SR-560-32500; (4) Distribution System Cost Methodologies for Distributed Generation Appendices, NREL/SR-560-32501.

  17. State Electricity Regulatory Policy and Distributed Resources: Distribution System Cost Methodologies for Distributed Generation

    Energy Technology Data Exchange (ETDEWEB)

    Shirley, W.; Cowart, R.; Sedano, R.; Weston, F.; Harrington, C.; Moskovitz, D.

    2002-10-01

    Designing and implementing credit-based pilot programs for distributed resources distribution is a low-cost, low-risk opportunity to find out how these resources can help defer or avoid costly electric power system (utility grid) distribution upgrades. This report describes implementation options for deaveraged distribution credits and distributed resource development zones. Developing workable programs implementing these policies can dramatically increase the deployment of distributed resources in ways that benefit distributed resource vendors, users, and distribution utilities. This report is one in the State Electricity Regulatory Policy and Distributed Resources series developed under contract to NREL (see Annual Technical Status Report of the Regulatory Assistance Project: September 2000-September 2001, NREL/SR-560-32733). Other titles in this series are: (1) Accommodating Distributed Resources in Wholesale Markets, NREL/SR-560-32497; (2) Distributed Resources and Electric System Re liability, NREL/SR-560-32498; (3) Distribution System Cost Methodologies for Distributed Generation, NREL/SR-560-32500; (4) Distribution System Cost Methodologies for Distributed Generation Appendices, NREL/SR-560-32501.

  18. State Policies on Human Capital Resource Management: Minnesota. Human Capital Resource Management Technical Brief

    Science.gov (United States)

    Bhatt, Monica; Behrstock, Ellen; Cushing, Ellen; Wraight, Sara

    2010-01-01

    Training, recruiting, developing, and supporting talented and effective educators throughout their careers is known as human capital resource management (HCRM) in education. HCRM has been identified in recent literature as one of the ways in which districts and states may increase school effectiveness and improve student learning (Heneman &…

  19. State Policies on Human Capital Resource Management: Indiana. Human Capital Resource Management Technical Brief

    Science.gov (United States)

    Meyer, Cassandra; Bhatt, Monica; Wraight, Sara; Behrstock, Ellen; Cushing, Ellen

    2010-01-01

    Training, recruiting, developing, and supporting talented and effective educators throughout their careers is known as human capital resource management (HCRM) in education. HCRM has been identified in recent literature as one of the ways in which districts and states may increase school effectiveness and improve student learning (Heneman &…

  20. State Policies on Human Capital Resource Management: Michigan. Human Capital Resource Management Technical Brief

    Science.gov (United States)

    Meyer, Cassandra; Bhatt, Monica; Wraight, Sara; Behrstock, Ellen; Cushing, Ellen

    2010-01-01

    Training, recruiting, developing, and supporting talented and effective educators throughout their careers is known as human capital resource management (HCRM) in education. HCRM has been identified in recent literature as one of the ways in which districts and states may increase school effectiveness and improve student learning (Heneman &…

  1. State Policies on Human Capital Resource Management: Illinois. Human Capital Resource Management Technical Brief

    Science.gov (United States)

    Meyers, Coby; Bhatt, Monica; Wraight, Sara; Behrstock, Ellen; Cushing, Ellen

    2010-01-01

    Training, recruiting, developing, and supporting talented and effective educators throughout their careers is known as human capital resource management (HCRM) in education. HCRM has been identified in recent literature as one of the ways in which districts and states may increase school effectiveness and improve student learning (Heneman &…

  2. State Policies on Human Capital Resource Management: Wisconsin. Human Capital Resource Management Technical Brief

    Science.gov (United States)

    Cushing, Ellen; Bhatt, Monica; Wraight, Sara; Behrstock, Ellen; Meyer, Cassandra

    2010-01-01

    Training, recruiting, developing, and supporting talented and effective educators throughout their careers is known as human capital resource management (HCRM) in education. HCRM has been identified in recent literature as one of the ways in which districts and states may increase school effectiveness and improve student learning (Heneman &…

  3. State Policies on Human Capital Resource Management: Iowa. Human Capital Resource Management Technical Brief

    Science.gov (United States)

    Behrstock, Ellen; Bhatt, Monica; Cushing, Ellen; Wraight, Sara

    2010-01-01

    Training, recruiting, developing, and supporting talented and effective educators throughout their careers is known as human capital resource management (HCRM) in education. HCRM has been identified in recent literature as one of the ways in which districts and states may increase school effectiveness and improve student learning (Heneman &…

  4. State Policies on Human Capital Resource Management: Ohio. Human Capital Resource Management Technical Brief

    Science.gov (United States)

    Bhatt, Monica; Wraight, Sara; Behrstock, Ellen; Cushing, Ellen

    2010-01-01

    Training, recruiting, developing, and supporting talented and effective educators throughout their careers is known as human capital resource management (HCRM) in education. HCRM has been identified in recent literature as one of the ways in which districts and states may increase school effectiveness and improve student learning (Heneman &…

  5. Principles to coordinate managed aquifer recharge with natural resource management policies in Australia

    Science.gov (United States)

    Ward, John; Dillon, Peter

    2012-08-01

    Managed aquifer recharge (MAR) is a tool available to water-resources managers that assists agencies to secure water supplies and protect aquifers and groundwater-dependent ecosystems in the face of climate change and growing water demand. Yet few natural-resources managers have access to a coordinated set of policies that enable the potential benefits of MAR to be fully realised in urban and rural areas. This paper reviews contemporary Australian water-resource policies and systematically applies a refined set of `robust separation of rights' principles based on secure entitlements, annual allocations and end-use obligations to guide the coordination of policies specific to each of the four operational processes central to MAR schemes: source water harvesting, aquifer recharge, recovery of stored water and end use. Particular attention is given to the formulation of policies relating to the recovery of water, including the feasibility for market exchange of permanent and temporary rights to recover recharged water, as these have the potential to greatly expand the role of MAR. Aquifer characteristics, existing groundwater extractions and potential third party effects need to be taken into account in determining both recovery entitlements and annual allocations. A transitional pathway to implement novel MAR policies is suggested.

  6. Maximising available resources: Equality and human rights proofing Irish fiscal policy

    Directory of Open Access Journals (Sweden)

    Murphy Mary P.

    2017-08-01

    Full Text Available The paper examines various rationales for applying equality and human rights proofing mechanisms to fiscal policy. The principle of using available resources to the maximum to progressively realise human rights, and not to erode the revenue capacity of developing nations to do likewise, is at the heart of emerging human rights norms. To date, Irish budgetary processes and major policy statements such as the Commission on Taxation or the draft outline National Plan on Business and Human Rights Strategy have not engaged with the principles of maximising available resources or extraterritoriality. Proofing fiscal policy is also relevant from the perspective of fiscal welfare where taxation instruments, traditionally used as a revenue-gathering mechanism, are increasingly used as distributional mechanisms to achieve policy outcomes in pensions, health, housing and employment, with important equality and distributive dimensions, particularly from gender, age and socioeconomic perspectives. A number of practical institutional mechanisms and evaluative questions can guide equality and human rights proofing of fiscal policy, but commitments to maximise resources to realise rights also need to be promoted through a public discourse which sees taxation as potential investment in society rather than a burden or cost on the economy.

  7. The Timber Resource Inventory Model (TRIM): a projection model for timber supply and policy analysis.

    Science.gov (United States)

    P.L. Tedder; R.N. La Mont; J.C. Kincaid

    1987-01-01

    TRIM (Timber Resource Inventory Model) is a yield table projection system developed for timber supply projections and policy analysis. TRIM simulates timber growth, inventories, management and area changes, and removals over the projection period. Programs in the TRIM system, card-by-card descriptions of required inputs, table formats, and sample results are presented...

  8. Human Resources Policies Compared: What Can the EU and the USA Learn from Each Other?

    Science.gov (United States)

    Tome, Eduardo

    2005-01-01

    Purpose: To compare in a fruitful way the human resources (HR) policies that exist in the European Union (EU) and in the United States of America (USA). Nowadays, the world is evolving to a situation in which big economic spaces like Brazil, Russia, India, China, Japan, the EU and the USA are becoming dominant. Those spaces can learn from one…

  9. The role of natural resource amenities in attracting retirees: implications for economic growth policy

    Science.gov (United States)

    Neelam C. Poudyal; Donald G. Hodges; H. Ken Cordell

    2008-01-01

    Increasing criticism of resource-extractive and polluting heavy duty industries in urbanareas, as well as continuing declines in timbering, farming and mining in rural areas, havecreated challenges for planners and policy makers seeking sustainable rural economies.Earlier studies have concluded that a...

  10. Workshop: Towards an integrative European perspective on health human resources policy: how and why?

    NARCIS (Netherlands)

    Batenburg, R.; Kuhlmann, E.

    2013-01-01

    Background: Across many countries, shortages and inefficient use of qualified healthcare staff – together with changes in the composition of the health professional workforce by age, gender and citizenship – have created an urgent call for health human resources policy, planning and management. In

  11. Policy Change and Its Effect on Australian Community-Based Natural Resource Management Practices

    Science.gov (United States)

    Cooke, Penelope R.; Hemmings, Brian C.

    2016-01-01

    The authors of this article report on a qualitative study of Australian community-based natural resource management groups known as Landcare groups. They discuss how four Landcare groups contributed to sustainability practices and how a policy change implemented in 2003 influenced the efforts of the groups to remain active in their activities.…

  12. Collection Development Policy. Media Retrieval Services--Pierce Library. Learning Resources. 1981 Rev.

    Science.gov (United States)

    Sawin, Philip, Jr., Ed.

    Policies for the selection, acquisition, and weeding of library materials, based on collection needs stated by academic departments and staff inputs, are listed for a university learning resource center. An alphabetical index is provided of major subject areas and subdivisions, which are assigned one of four level designators indicating the depth…

  13. A resource for developing an evidence synthesis report for policy-making

    DEFF Research Database (Denmark)

    Eklund Karlsson, Leena; Takahashi, Ryoko

    to public health questions by summarizing the best available global and local findings from peer-reviewed and grey literature, as well as policy options, and proposes general directions, strategies and actions for consideration. This resource has been developed to outline key approaches, methods...

  14. Factors that explain how policy makers distribute resources to mental health services.

    Science.gov (United States)

    Corrigan, Patrick W; Watson, Amy C

    2003-04-01

    Advocates hope to influence the resource allocation decisions of legislators and other policy makers to capture more resources for mental health programs. Findings from social psychological research suggest factors that, if pursued, may improve advocacy efforts. In particular, allocation decisions are affected by policy makers' perceptions of the scarcity of resources, effectiveness of specific programs, needs of people who have problems that are served by these programs, and extent of personal responsibility for these problems. These perceptions are further influenced by political ideology. Conservatives are motivated by a tendency to punish persons who are perceived as having personal responsibility for their problems by withholding resources, whereas liberals are likely to avoid tough allocation decisions. Moreover, these perceptions are affected by political accountability, that is, whether politicians perceive that their constituents will closely monitor their decisions. Just as the quality of clinical interventions improves when informed by basic research on human behavior, the efforts of mental health advocates will be advanced when they understand the psychological forces that affect policy makers' decisions about resources.

  15. Macroeconomic Policy for Growth and Poverty Reduction: An Application to Post-Conflict and Resource-Rich Countries

    OpenAIRE

    Degol Hailu; John Weeks

    2011-01-01

    A fundamental shift in macroeconomic policy thinking is taking place. This shift opens a space for implementing policies that promote growth and reduce poverty in developing countries. In this paper, policies for post-conflict and resource-rich economies are outlined. Fiscal policy would focus on revenue mobilization, scaling-up public investment, and preventing over-heating. Monetary policies would revive the financial sector, prevent inflationary pressures and stimulate private sector inves...

  16. Climate change and mountain water resources: overview and recommendations for research, management and policy

    Directory of Open Access Journals (Sweden)

    D. Viviroli

    2011-02-01

    Full Text Available Mountains are essential sources of freshwater for our world, but their role in global water resources could well be significantly altered by climate change. How well do we understand these potential changes today, and what are implications for water resources management, climate change adaptation, and evolving water policy? To answer above questions, we have examined 11 case study regions with the goal of providing a global overview, identifying research gaps and formulating recommendations for research, management and policy.

    After setting the scene regarding water stress, water management capacity and scientific capacity in our case study regions, we examine the state of knowledge in water resources from a highland-lowland viewpoint, focusing on mountain areas on the one hand and the adjacent lowland areas on the other hand. Based on this review, research priorities are identified, including precipitation, snow water equivalent, soil parameters, evapotranspiration and sublimation, groundwater as well as enhanced warming and feedback mechanisms. In addition, the importance of environmental monitoring at high altitudes is highlighted. We then make recommendations how advancements in the management of mountain water resources under climate change could be achieved in the fields of research, water resources management and policy as well as through better interaction between these fields.

    We conclude that effective management of mountain water resources urgently requires more detailed regional studies and more reliable scenario projections, and that research on mountain water resources must become more integrative by linking relevant disciplines. In addition, the knowledge exchange between managers and researchers must be improved and oriented towards long-term continuous interaction.

  17. Resource management and scheduling policy based on grid for AIoT

    Science.gov (United States)

    Zou, Yiqin; Quan, Li

    2017-07-01

    This paper has a research on resource management and scheduling policy based on grid technology for Agricultural Internet of Things (AIoT). Facing the situation of a variety of complex and heterogeneous agricultural resources in AIoT, it is difficult to represent them in a unified way. But from an abstract perspective, there are some common models which can express their characteristics and features. Based on this, we proposed a high-level model called Agricultural Resource Hierarchy Model (ARHM), which can be used for modeling various resources. It introduces the agricultural resource modeling method based on this model. Compared with traditional application-oriented three-layer model, ARHM can hide the differences of different applications and make all applications have a unified interface layer and be implemented without distinction. Furthermore, it proposes a Web Service Resource Framework (WSRF)-based resource management method and the encapsulation structure for it. Finally, it focuses on the discussion of multi-agent-based AG resource scheduler, which is a collaborative service provider pattern in multiple agricultural production domains.

  18. Norwegian resource policy: The production rate for Norwegian petroleum resources; Norsk ressurspolitikk: Utvinningstempoet for norske petroleumsressurser

    Energy Technology Data Exchange (ETDEWEB)

    Schreiner, P.

    1995-12-31

    Petroleum activities have become a large industry in Norway. This has led to extensive changes in Norwegian economy and society. In the public debate on this activity there has been little discussion of what would be the most profitable production rate. However, it is generally agreed that the great wealth implied by the petroleum resources must be managed in ways suitable to both present and coming generations. This report discusses the production rate based on the following questions: (1) How high can the production rate be before the petroleum activities and the expenditure of the income from them influence the remaining Norwegian economy too strongly? (2) How much of this wealth should reasonably be used by present generations and how much should be left for future generations? There is much to gain from a high tempo and from relocating some of the petroleum wealth. The possibilities of influencing the production rate are mainly connected with the allotments of production licences. The consequences of uncertainties in the petroleum activities for the choice of exploitation tempo are unclear. The environment is not much affected by the production rate. The contractor activity has become Norway`s largest industry. 42 refs., 14 figs., 2 tabs.

  19. Systems approach to materials policy. [Role of renewable resources for energy needs

    Energy Technology Data Exchange (ETDEWEB)

    Hoffman, K C; Bhagat, N

    1976-01-01

    A comprehensive systems framework for materials policy analysis, the Reference Materials System (RMS), has been developed and is described in this paper. Specifically, the RMS provides a systematic approach to organizing engineering process-type information regarding material flows, energy requirements, costs, and environmental impacts corresponding to various materials on all processes ranging from extraction of resources through their refinement, transportation, fabrication, installation, and maintenance at the point of end use, as well as recycling. This system can be used for the assessment of material technologies, substitutions and policies, and has been applied to assess the role of renewable materials as substitutes for energy-intensive nonrenewables.

  20. Improved Management of Water and Natural Resources Requires Open, Cognizant, Adaptive Science and Policy

    Science.gov (United States)

    Glynn, P. D.; Voinov, A. A.; Shapiro, C. D.; Jenni, K. E.

    2017-12-01

    Water issues impact the availability and use of other natural resources as well as environmental conditions. In an increasingly populated hyper-connected world, water issues are increasingly "wicked problems": complex problems with high uncertainties and no independent observers. Water is essential to life, and life affects water quality and availability. Scientists, managers, decision-makers, and the greater public all have a stake in improving the management of water resources. In turn, they are part of the systems that they are studying, deciding on, affecting, or trying to improve. Governance of water issues requires greater accessibility, traceability, and accountability (ATA) in science and policy. Water-related studies and decision-making need transdisciplinary science, inclusive participatory processes, and consideration and acceptance of multiple perspectives. Biases, Beliefs, Heuristics, and Values (BBHV) shape much of our perceptions and knowledge, and inevitably, affect both science and policy. Understanding the role of BBHV is critical to (1) understanding individual and group judgments and choices, (2) recognizing potential differences between societal "wants" and societal "needs", and (3) identifying "winners" and "losers" of policy decisions. Societal acceptance of proposed policies and actions can be fostered by enhancing participatory processes and by providing greater ATA in science, in policy, and in development of the laws, rules, and traditions that constrain decision-making. An adaptive science-infused governance framework is proposed that seeks greater cognizance of the role of BBHV in shaping science and policy choices and decisions, and that also seeks "Open Traceable Accountable Policy" to complement "Open Science". We discuss the limitations of the governance that we suggest, as well as tools and approaches to help implementation.

  1. Online Self-testing Resources Prepared by Peer Tutors as a Formative Assessment Tool in Pharmacology Courses.

    Science.gov (United States)

    Lull, Melinda E; Mathews, Jennifer L

    2016-09-25

    Objective. To assess the effectiveness of optional online quizzes written by peer tutors in a pharmacology course for doctor of pharmacy students. Methods. Online quizzes were written by peer tutors for second-year pharmacy students. Quizzes reflected the material taught during lecture and were in a format similar to that of the examinations. Data related to performance on each quiz and each examination were collected throughout the semester. At the end of the semester, students and peer tutors were surveyed to gather information on the utility and success of the quizzes. Results. Students taking online quizzes performed significantly better on examinations than those who did not take quizzes. In addition, students received higher scores on examinations than when practicing with the quizzes. Surveys suggest that students liked the quizzes and felt they increased their confidence and performance on examinations. Conclusion. The quizzes were beneficial to student performance on examinations as well as student perception of performance and confidence going into the examinations. Quizzes were also beneficial learning experiences for peer tutors.

  2. Deadlock Avoidance Policy in Mobile Wireless Sensor Networks with Free Choice Resource Routing

    Directory of Open Access Journals (Sweden)

    Prasanna Ballal

    2008-11-01

    Full Text Available Efficient control schemes are required for effective cooperation of robot teams in a mobile wireless sensor network. If the robots (resources are also in charge of executing multiple simultaneous missions, then risks of deadlocks due to the presence of shared resources among different missions increase and have to be tackled. Discrete event control with deadlock avoidance has been used in the past for robot team coordination for the case of multi reentrant flowline models with shared resources. In this paper we present an analysis of deadlock avoidance for a generalized case of multi reentrant flow line systems (MRF called the Free Choice Multi Reentrant Flow Line systems (FMRF. In FMRF, some tasks have multiple resource choices; hence routing decisions have to be made and current results in deadlock avoidance for MRF do not hold. This analysis is based on the so-called Circular Waits (CW of the resources in the system. For FMRF, the well known notions of Critical Siphons and Critical Subsystems must be generalized and we redefine these objects for such systems. Our second contribution provides a matrix formulation that efficiently computes the objects required for deadlock avoidance in FMRF systems. A MAXWIP dispatching policy is formulated for deadlock avoidance in FMRF systems. According to this policy, deadlock in FMRF is avoided by limiting the work in progress (WIP in the critical subsystems of each CW. Implemented results of the proposed scheme in a WSN test-bed is presented in the paper.

  3. Resource, capital, and labor requirements of the National Energy Policy Plan: 1980 to 2000

    Energy Technology Data Exchange (ETDEWEB)

    D' Acierno, J.; Beller, M.; Lamontagne, J.

    1982-08-01

    Recent prominent forecasts of future energy supply include a major role for technologies that will require substantial capital, labor, and material inputs. This report defines the direct resource requirements for the scenarios presented in the National Energy Policy Plan (NEPP), and attempts to identify potential resource constraints. The Energy Supply Planning Model (ESPM) was utilized to derive resource requirements based on energy demand, supply, and price projections under the National Energy Policy Plan. Detailed requirements for capital, person-power, materials, equipment, and land and water resources are identified on an annual basis to the year 2000. Although no obvious resource constraints were identified based directly on requirements for energy facilities, the scope of the study did not allow for consideration of activities in other areas (e.g., defense) which, when coupled with energy facility requirements, might create critical shortages in some areas (e.g., engineering labor). Also, manufacturing capability for certain specialized equipment items (e.g., large pressure vessels) which might impose limits were not explicitly considered in this analysis.

  4. Deadlock Avoidance Policy in Mobile Wireless Sensor Networks with Free Choice Resource Routing

    Directory of Open Access Journals (Sweden)

    Prasanna Ballal

    2008-09-01

    Full Text Available Efficient control schemes are required for effective cooperation of robot teams in a mobile wireless sensor network. If the robots (resources are also in charge of executing multiple simultaneous missions, then risks of deadlocks due to the presence of shared resources among different missions increase and have to be tackled. Discrete event control with deadlock avoidance has been used in the past for robot team coordination for the case of multi reentrant flowline models with shared resources. In this paper we present an analysis of deadlock avoidance for a generalized case of multi reentrant flow line systems (MRF called the Free Choice Multi Reentrant Flow Line systems (FMRF. In FMRF, some tasks have multiple resource choices; hence routing decisions have to be made and current results in deadlock avoidance for MRF do not hold. This analysis is based on the so-called Circular Waits (CW of the resources in the system. For FMRF, the well known notions of Critical Siphons and Critical Subsystems must be generalized and we redefine these objects for such systems. Our second contribution provides a matrix formulation that efficiently computes the objects required for deadlock avoidance in FMRF systems. A MAXWIP dispatching policy is formulated for deadlock avoidance in FMRF systems. According to this policy, deadlock in FMRF is avoided by limiting the work in progress (WIP in the critical subsystems of each CW. Implemented results of the proposed scheme in a WSN test-bed is presented in the paper.

  5. A Systemic and Systematic Approach to the Development of a Policy Mix for Material Resource Efficiency

    Directory of Open Access Journals (Sweden)

    Tomas Ekvall

    2016-04-01

    Full Text Available Increasing material use efficiency is important to mitigate future supply risks and minimize environmental impacts associated with the production of the materials. The policy mix presented in this paper aims to contribute to reducing the use of virgin metals in the EU by 80% by 2050 without significant shifting of burdens to other material resources, environmental impacts, or parts of the world. We used a heuristic framework and a systems perspective for designing the policy mix that combines primary instruments designed to increase material efficiency, recycling and substitution of materials (a materials tax, the extended producer responsibility, technical regulations, and environmental taxes and supportive instruments aimed to reduce barriers to implementing the primary instruments and to contribute towards the policy objectives (e.g., research and development support, and advanced recycling centers. Furthermore, instruments were designed so as to increase political feasibility: e.g., taxes were gradually increased as part of a green fiscal reform, and border-tax adjustments were introduced to reduce impacts on competitiveness. However, even in such a policy mix design ongoing ex-ante assessments indicate that the policy mix will be politically difficult to implement—and also fall short of achieving the 80% reduction target. Nonetheless, we suggest combining primary and supportive instruments into coherent and dynamic policy mixes as a promising step towards system reconfigurations for sustainability.

  6. Catchment scale water resource constraints on UK policies for low-carbon energy system transition

    Science.gov (United States)

    Konadu, D. D.; Fenner, R. A.

    2017-12-01

    Long-term low-carbon energy transition policy of the UK presents national scale propositions of different low-carbon energy system options that lead to meeting GHG emissions reduction target of 80% on 1990 levels by 2050. Whilst national-scale assessments suggests that water availability may not be a significant constrain on future thermal power generation systems in this pursuit, these analysis fail to capture the appropriate spatial scale where water resource decisions are made, i.e. at the catchment scale. Water is a local resource, which also has significant spatio-temporal regional and national variability, thus any policy-relevant water-energy nexus analysis must be reflective of these characteristics. This presents a critical challenge for policy relevant water-energy nexus analysis. This study seeks to overcome the above challenge by using a linear spatial-downscaling model to allocate nationally projected water-intensive energy system infrastructure/technologies to the catchment level, and estimating the water requirements for the deployment of these technologies. The model is applied to the UK Committee on Climate Change Carbon Budgets to 2030 as a case study. The paper concludes that whilst national-scale analyses show minimal long-term water related impacts, catchment level appraisal of water resource requirements reveal significant constraints in some locations. The approach and results presented in this study thus, highlights the importance of bringing together scientific understanding, data and analysis tools to provide better insights for water-energy nexus decisions at the appropriate spatial scale. This is particularly important for water stressed regions where the water-energy nexus must be analysed at appropriate spatial resolution to capture the full water resource impact of national energy policy.

  7. How Policies Affect the Use of Plant Genetic Resources: The Experience of the CGIAR

    OpenAIRE

    Isabel, Lopez Noriega; Michael, Halewood; Gea, Galluzzi; Ronnie, Vernooy; Enrico, Bertacchini; Devendra, Gauchan; Eric, Welch

    2013-01-01

    There is growing recognition that sustainable intensification of agricultural production systems and their successful adaptation to changes in climate will depend upon the improved access to, and use of, genetic diversity. This paper analyzes how the collection, use and distribution of plant genetic resources by the Consortium of International Research Centers of the CGIAR are influenced by international and national policies, treaties and agreements. Some concerns exist among CGIAR scientist...

  8. Policy in management based on corruption growth of resources agropolitan in the Gorontalo Province

    Science.gov (United States)

    Wantu, S. M.; Moonti, U.; Wantu, A.

    2018-02-01

    Gorontalo was formed as a new province in Indonesia as a producer of national maize, but until now the agropolitan-based agricultural development condition is still inadequate and needs to be developed well. Thus, it is necessary to conduct a governance-related study on empowering farmers in order to increase their capacity in exploring the agricultural sector. This study aims to see the need for local government policies in managing human resources in the agricultural sector in this case the potential and contribution of farmers in creating new jobs in rural areas. This study uses a qualitative approach to the use of secondary data and primary data as a basis for tracing or researching local government management policies in empowering farmers to improve their welfare and also how this policy is expected to organize effective market mechanisms for farmers.

  9. Does Integrated Water Resources Management Support Institutional Change? The Case of Water Policy Reform in Israel

    Directory of Open Access Journals (Sweden)

    Itay Fischhendler

    2010-03-01

    Full Text Available Many international efforts have been made to encourage integrated water resources management through recommendations from both the academic and the aid and development sectors. Recently, it has been argued that integrated water resources management can help foster better adaptation of management and policy responses to emerging water crises. Nevertheless, few empirical studies have assessed how this type of management works in practice and what an integrated water management system implies for institutional adaptation and change. Our assessment of the Israeli water sector provides one view of how they can be shaped by an integrated structure in the water sector. Our analysis of recent efforts to adapt Israel's water management system to new conditions and uncertainties reveals that the interconnectedness of the system and the consensus decision-making process, led by a dominant actor who coordinates and sets the policy agenda, tends to increase the complexity of negotiations. In addition, the physical integration of water management leads to sunk costs of large-scale physical infrastructure. Both these factors create a path dependency that empowers players who receive benefits from maintaining the existing system. This impedes institutional reform of the water management system and suggests that integrated water resources management creates policy and management continuity that may only be amenable to incremental changes. In contrast, real adaptation that requires reversibility and the ability to change management strategies in response to new information or monitoring of specific management outcomes.

  10. Formulation of an Integrated Model for Freshwater Resources Policy Evaluation in Jordan

    Science.gov (United States)

    Gorelick, S.; Yoon, J.; Gawel, E.; Klauer, B.; Klassert, C. J. A.; Sigel, K.; Tilmant, A.; Lachaut, T.; Avisse, N.; Harou, J. J.; Padula, S.; Mustafa, D.

    2014-12-01

    Jordan is one of the four water poorest countries in the world. It is a highly vulnerable arid region whose freshwater system is at a tipping point due to the confluence of severely limited water supplies, rapid population growth, refugee influxes, climate change and variability, internal and transboundary competition for shared freshwater resources, and institutional impediments. Our team is engaged in an interdisciplinary effort aimed at developing a new approach to evaluate policies that enhance sustainability of freshwater resource systems. Our work adopts a multi-agent modeling framework that incorporates institutional complexity to evaluate policy instruments for improving water security in Jordan. We are developing this model using a modular approach, integrating biophysical modules that simulate natural and engineered phenomena (e.g., groundwater-surface water flow, reservoir storage, network routing, salt balance, and crop yield) with human modules that represent behavior at multiple scales of decision making. The human modules adopt a multi-agent simulation approach, defining agents as autonomous decision-makers at the government, administrative, organizational, and user levels. Our goal is to construct a suite of policy intervention scenarios that will form the basis for analysis of freshwater sustainability. This work has benefitted from a strong working relationship with leaders of the water sector in Jordan. Our approach and the merit of the policy interventions should have significant transfer value to other water-stressed regions.

  11. American Polonia’s Resources Of Ifluence And Us Foreign Policy

    Directory of Open Access Journals (Sweden)

    I. D. Loshkariov

    2017-01-01

    Full Text Available The article analyzes resources of political influence on the foreign policy of the country of residence that Polish diaspora in the United States possesses. This analysis is useful for two reasons. Firstly, it will expand the focus of research in the study of pressure groups and their influence on the American foreign policy. Secondly, the Polish diaspora in the United States is rarely the object of research in migrant and ethnic lobbying, despite its the significant share of the country’s population. Analysis of the given resources that the Polish diaspora (American Polonia has leads to the following. Firstly, the foreign policy agenda of the Polish diaspora in the United States faces no strong opponents. This fact means the diaspora has sufficiently developed structural resource. In addition, the Polish diaspora possesses an organizational resource: its institutions are in close cooperation and are coordinated by the Polish American Congress. Secondly, the Polish diaspora in the US is a significant group of the population, especially in the states of Wisconsin, Michigan, Connecticut, New York and Illinois. However, its electoral and financial capacities are not used to the fullest extent. Finally, there are certain difficulties with the discursive political resource of Polish diaspora. The social and political perception provides of Polonia in the USA two opposing narratives. The first one stresses that it is important for the Americans of Polish descent to share such values as democracy, defending his position, including by military means. The second narrative is a reproduction of widespread stereotypes about Poles, including in the popular culture. Thus, institutions of the American Polonia face several tasks. The most important tasks are the search for new ways of political mobilization of the diaspora and the formation of a balanced image of Polish Americans in the social and political perception in the United States.

  12. [Priorities for health policy and systems research focused on human resources in health].

    Science.gov (United States)

    Reveiz, Ludovic; Chapman, Evelina; Flórez, Carlos E Pinzón; Torres, Rubén

    2013-11-01

    Identify priorities for health policy and systems research related to human resources in Latin America and Caribbean countries. An online survey was designed based on a search in PubMed, Cochrane Library, and LILACS that contributed previously prioritized research questions. Respondents, mainly researchers and decision-makers, were identified through various sources. The first round, directed at researchers, aimed at refining and adding research questions and prioritizing questions that researchers regarded as relevant or very relevant. The second round was directed at researchers and decision-makers. A question was considered a priority when 50% (or more) of respondents described it as "relevant" or "very relevant." The first round included 20 questions on human resources and 33/66 researchers responded. Questions suggested by the researchers were added, resulting in 26 questions for the second round, which were sent to 121 researchers and decision-makers. Respondent representation by country was uniform in both rounds. In the second round, 14/26 (54%) questions were described as very relevant. Priority issues related to regulation of the market, integration of education and health care needs, and distribution of human resources. The response rate was 50% in the first round (33/66), and 34% in the second round (41/121). The results of this exercise provide a starting point for mobilization of resources for health policy and systems research. Identification of health systems research priorities is an effective and efficient strategy for reorienting political, financial, management, and social organization efforts for attaining universal health coverage.

  13. Depreciation Policy as a Key Element of Enterprise Technical Resources Management

    Directory of Open Access Journals (Sweden)

    Puyda Halya V.

    2014-01-01

    Full Text Available Depreciation policy and depreciation in particular play a number of functions at an enterprise. The modern stage of scientific studies describes the essence and breadth of the “depreciation” notion for an enterprise rather deeply. The article considers depreciation as a tool of managing technical resources at an enterprise. It conducts a critical review of modern approaches to determination of depreciation and identifies its functions. The author carries out a deep analysis of modern views on the existing concepts of depreciation essence and its place in managing enterprise assets. The article reveals the essence of the “depreciation policy” notion. It provides examples of influence of different types of the depreciation policy upon the state and rate of renovation of technical resources at an enterprise. In the result the author offers types of the depreciation policy of an enterprise depending on the desired rate of renovation of the technical base and desired volume of the capital released into circulation.

  14. STRUCTURING DEFENSE POLICIES FOR THE DEFENSE AND CONTROL OF STRATEGIC NATURAL RESOURCES

    Directory of Open Access Journals (Sweden)

    GABRIEL DE PAULA

    2018-02-01

    Full Text Available During the last decade, there has been a reconfiguration of a new geopolitical scenario. This new scenario focus on the assessment about strategic natural resources (oil, gas and water, and less important, biodiversity, food and fertile land and its spatial condition (the resources are in a territory which is politically defined by boundaries or zone of influence. The scenario in South America is not far from that international dynamic, which affects in different levels the strategic lines of national defense policies in Brazil, Venezuela and (in less degree Argentina. In that way, competence and confluence scenarios are defined, which may have variability in the conflict level, such as a military confrontation or cooperation mechanisms (as the South America Defense Council. These scenarios are geographically located in: oil and gas basins, Amazonas, water resources, Antarctica, Atlantic Ocean and fertile land. The defense strategies set parameters for the design of the armed forces, as far as the hypothesis of conflicts above-mentioned applied. Thus, the defense administration reconfigured the capabilities of the Armed Forces (logistic, personnel, doctrine, resources, surveillance, in order to achieve the mission of control the regions where availability of natural resources exists.

  15. Continuity and change in human resources policies for health: lessons from Brazil.

    Science.gov (United States)

    Buchan, James; Fronteira, Ines; Dussault, Gilles

    2011-07-05

    This paper reports on progress in implementing human resources for health (HRH) policies in Brazil, in the context of the implementation and expansion of the Unified Health System (Sistema Unico de Saúde - SUS).The three main objectives were: i) to reconstruct the chronology of long term HRH change in Brazil, and to identify and discuss the precursors, drivers, and enablers for these changes over a long time period; (ii) to examine how change was achieved by describing facilitators and constraints, and how policies were adapted to deal with the latter; and (iii) to report on the current situation and draw policy implications. A mixed methods approach was used. A literature review was conducted using pre-defined keywords; and stakeholders were contacted and asked to provide relevant information, data and policy reports. There are two key features of HRH change which are related to the implementation of SUS which merit attention: the achievement of staffing growth, and the improvement in HRH policy making and management. Staff growth rates across the period have been high enough to exceed population growth rates. As a consequence, the ratio of staff to population has improved. In 1990 the physician ratio per 1000 inhabitants was 1.12. In 2007, it was 1.74. Another critical factor in achieving staffing growth has been HRH policy making capacity and influence within the political establishment. Policies have had to adapt to changing circumstances, whilst focusing on sequential improvements aimed at achieving long term goals. The end objectives, of improving care and access to care, have been kept in view. No one Ministry could secure all the resources and impetus for change that has been required, hence the need for inter-ministry, inter-governmental and inter-agency collaboration, and the development of alliances of shared interest. Across the period of thirty years or more, not all initiatives have been equally successful, but a momentum has been maintained. There

  16. Human Resources Management and Effective Function of WLB Policies: A cross-national comparison of influence on workplace productivity (Japanese)

    OpenAIRE

    MATSUBARA Mitsuyo

    2011-01-01

    This study compares Japan and four other countries (the United Kingdom, the Netherlands, Sweden, and Germany) with regard to human resources management, focusing on companies where work-life balance (WLB) policies are believed to have had a positive effect on workplace productivity. It aims to clarify the challenges in promoting WLB policies in Japan from the viewpoint of human resources management. The study has found the following: First, while incentive systems in the four foreign countrie...

  17. Anesthetic pharmacology

    National Research Council Canada - National Science Library

    Evers, Alex S; Maze, M; Kharasch, Evan D

    2011-01-01

    ...: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology...

  18. Taking Legislators to the Field: Communicating with Policy Makers about Natural Resource Issues

    Science.gov (United States)

    Sawin, R. S.; Buchanan, R. C.

    2006-12-01

    Policy makers are among the most important audiences for scientific information. In particular, legislators, legislative staff, governmental agency staff, business leaders, environmental leaders, and others need accurate, objective natural-resource information to make policy decisions. This audience is busy and difficult to reach with technical information. As part of its public outreach program, the Kansas Geological Survey (a division of the University of Kansas) communicates directly with policy makers through an annual field conference. Operated since 1995, the conference presents information by combining field experiences, presentations by experts, and participant interaction. The primary objective is to give policy makers first-hand, unbiased information about the state's natural resource issues. The field conference takes policy makers to locations where natural resources are produced or used, or where there are important environmental issues, introducing them to experts and others who carry out (or are affected by) their decisions. The conference consists of three days of site visits, presentations, hands-on activities, and panel discussions. Participation is by invitation. Participants pay a small fee, but most costs are covered by co-sponsors, usually other state or local agencies, that are recruited to help defray expenses. Participants receive a guidebook before the trip. Travel is by chartered bus; lodging and meals are provided. Conferences have focused on topics (such as energy or water) or regions of the state. The most recent conference focused on cross-boundary issues and included stops in Kansas, Oklahoma, and Missouri. Written, post-conference evaluations are extremely positive. Legislators report that they regularly use conference information and contacts during the law-making process; conference information played a direct role in decisions related to underground natural-gas storage rules, water-rights by-back legislation, and sand and gravel

  19. POLICY DEVELOPMENT TRAINING AND EDUCATION RESOURCES TO REFORM THE LOCAL GOVERNMENT DISTRICT OF MAKASSAR SIDENRENG RAPPANG

    Directory of Open Access Journals (Sweden)

    Syamsuddin Maldun

    2015-02-01

    Full Text Available This research aims to know and study the strategy of resource development policy reform of local government district of Makassar Sidenreng Rappang. The research method used is descriptive qualitative study type, while the phenomenological approach is used. This is intended to give description in a systematic, factual and actual response object is examined. Results of the research implementation of education and training is not conducted in a planned and timely to get quality apparatus of the abilities, knowledge, skills, expertise, and job skills, as well as a good mental attitude, and optimal performance. Whereas in the era of regional autonomy, it takes the resources of local government apparatus that is intelligent and responsive to the needs of an increasingly complex society services. 

  20. Water resource quality policy: the approach adopted by the Department of Water Affairs and Forestry under the Water Law principles

    CSIR Research Space (South Africa)

    Harris

    1999-01-01

    Full Text Available for all, forever." The development of a water resource protection policy was begun in that review. This paper describes the major aspects of the policy at one point in a process of rapid development. Initial proposals are to use the concept of ecological...

  1. Can legality verification enhace local rights to forest resources? Piloting the policy learning protocol in the Peruvian forest context

    Science.gov (United States)

    B. Cashore; I. Visseren-Hamakers; P. Caro Torres; W. de Jong; A. Denvir; D. Humphreys; Kathleen McGinley; G. Auld; S. Lupberger; C. McDermott; S. Sax; D. Yin

    2016-01-01

    This report, “Can Legality Verification Enhance Local Rights to Forest Resources? Piloting the policy learning protocol in the Peruvian forest context,” reports on the testing of the application of the 11-step Policy Learning Protocol in Peru in 2015-16. The Protocol (Cashore et al. 2014) enables actors to draw from international policy initiatives in order to improve...

  2. «Love and Other Drugs»: A film with a significant number of resources for training in pharmacology and therapeutics

    Directory of Open Access Journals (Sweden)

    Cándido HERNÁNDEZ-LÓPEZ

    2016-04-01

    Full Text Available The methods and results of a practical exercise based on the movie Love and Other Drugs (2010 by Edward Zwick are presented. The exercise was part of the teaching activities in General Pharmacology, in the third year of the medicine degree. The teaching objectives included to perceive different views on the use of drugs (marketer/prescriber/ patient/society, to obtain critical opinions on promotional activities and to get familiar with the ethical codes controlling advertising activities. Two sessions of 2.5 hours were done, separated by two weeks. During the first one the activity was introduced and organized, and the film was viewed. During the second session the students exposed and discussed work which had been prepared guided by a number of specific questions. The resources present in the film were an excellent vehicle for establishing a strong interaction with students, to guide reflections on the importance of drugs in society, to address the need for ethical codes, the differences between licensed indication and off-label use, and to emphasise the use of the SmPC as key reference information. In conclusion, the exercise served to provide students some tools for ethical consideration on their future responsibilities as decision makers in drug prescribing.

  3. Resources, policy, and research activities of biofuel in Indonesia: A review

    Directory of Open Access Journals (Sweden)

    Yanuandri Putrasari

    2016-11-01

    Full Text Available Fossil fuels as the main energy source of every country now predicted will be ended no more than 40 years. Therefore, alternative fuel such as biofuel has been developed by many countries including Indonesia. Indonesia as one of the highest populated country and has wide areas of agriculture, forest and crop field is potential to be the highest biofuel production in the world. However, after one decade since the Government of Indonesia launched the energy Policy in 2006, appears to be interesting that the biofuels progress in Indonesia seen not well developed. One of the basic weaknesses is the program only applied to the specific area with a high biofuel resource by central government without support by local government. Furthermore, the target of biofuel programs seems to be very high or too ambitious, while the condition of the people still very traditional which can be seen from the lifestyle and their energy consumption. This paper provides in detail a review of several topics related to resource, energy consumption, policy and the research and development activities of biofuel in Indonesia. As a discussion, some recommendation provided to encourage the biofuel development in the near future.

  4. Energy policy, aid, and the development of renewable energy resources in Small Island Developing States

    International Nuclear Information System (INIS)

    Dornan, Matthew; Shah, Kalim U.

    2016-01-01

    Small Island Developing States (SIDS) have established ambitious renewable energy targets. The promotion of renewable energy has been motivated by several factors: a desire to lessen dependence on fossil fuels, to attract development assistance in the energy sector, and to strengthen the position of SIDS in climate change negotiations. Here we explore the interplay between the role of aid and energy policy in the development of renewable energy resources in SIDS. We find that the importance of development assistance has implications for the sustainability of renewable energy development, given that funding is not always accompanied by necessary energy policy reforms. We also identify energy efficiency and access to modern energy services as having received insufficient attention in the establishment and structure of renewable energy targets in SIDS, and argue that this is problematic due to the strong economic case for such investments. - Highlights: • SIDS have established the world's most ambitious renewable energy targets. • These are motivated by fossil fuel dependence and climate change vulnerability. • Aid dependence has influenced the ambition of renewable energy targets. • Energy efficiency and energy access have received insufficient attention. • Domestic policy reforms necessary for the achievement of targets has been limited.

  5. State Electricity Regulatory Policy and Distributed Resources: Distributed Resource Distribution Credit Pilot Programs--Revealing the Value to Consumers and Vendors

    Energy Technology Data Exchange (ETDEWEB)

    Moskovitz, D.; Harrington, C.; Shirley, W.; Cowart, R.; Sedano, R.; Weston, F.

    2002-10-01

    Designing and implementing credit-based pilot programs for distributed resources distribution is a low-cost, low-risk opportunity to find out how these resources can help defer or avoid costly electric power system (utility grid) distribution upgrades. This report describes implementation options for deaveraged distribution credits and distributed resource development zones. Developing workable programs implementing these policies can dramatically increase the deployment of distributed resources in ways that benefit distributed resource vendors, users, and distribution utilities. This report is one in the State Electricity Regulatory Policy and Distributed Resources series developed under contract to NREL (see Annual Technical Status Report of the Regulatory Assistance Project: September 2000-September 2001, NREL/SR-560-32733). Other titles in this series are: (1) Accommodating Distributed Resources in Wholesale Markets, NREL/SR-560-32497; (2) Distributed Resources and Electric System Re liability, NREL/SR-560-32498; (3) Distribution System Cost Methodologies for Distributed Generation, NREL/SR-560-32500; (4) Distribution System Cost Methodologies for Distributed Generation Appendices, NREL/SR-560-32501.

  6. How stakeholder roles, power, and negotiation impact natural resource policy: A political economy view

    Science.gov (United States)

    Caughlan, L.

    2002-01-01

    Natural resource management decisions are complicated by multiple property rights, management objectives, and stakeholders with varying degrees of influence over the decision making process. In order to make efficient decisions, managers must incorporate the opinions and values of the involved stakeholders as well as understand the complex institutional constraints and opportunities that influence the decision-making process. Often this type of information is not understood until after a decision has been made, which can result in wasted time and effort.The purpose of my dissertation was to show how institutional frameworks and stakeholder involvement influence the various phases of the resource management decision-making process in a public choice framework. The intent was to assist decision makers and stakeholders by developing a methodology for formally incorporating stakeholders'' objectives and influence into the resource management planning process and to predict the potential success of rent-seeking activity based on stakeholder preferences and level of influence. Concepts from decision analysis, institutional analysis, and public choice economics were used in designing this interdisciplinary framework. The framework was then applied to an actual case study concerning elk and bison management on the National Elk Refuge and Grand Teton National Park near Jackson, Wyoming. The framework allowed for the prediction of the level of support and conflict for all relevant policy decisions, and the identification of each stakeholder''s level of support or opposition for each management decision.

  7. Clinical pharmacology

    African Journals Online (AJOL)

    General anaesthesia should be considered for potentially difficult procedures and for those involving large wounds. RENEÉ DE WAAL, MB ChB, MFPM. MARC BLOCKMAN, BPharm,. MB ChB, Dip Int Res Ethics, MMed. (Clin Pharmacol), AFCCP. Division of Clinical Pharmacology Department of Medicine University of Cape ...

  8. Local and Regional Authorities as Resources for Implementing Universal Design Policy in Norway.

    Science.gov (United States)

    Lund, Einar

    2016-01-01

    The municipalities and regional authorities are in general resources for achieving national goals. Their management and works are crucial to the development and implementation of Universal Design. Through several programmes, national authorities have worked for activating the local and regional levels. The results are visible. We can see a long-term national strategy to help make society accessible to everyone and prevent discrimination. Participating municipalities and regional authorities are now able to create their own policy and strategies and implement solutions. The national programs have involved interested and motivated municipalities. All the 18 counties in Norway have been involved more or less in different periods and the same with up to a third of the about good 400 municipalities.

  9. Forest economics and policy in a changing environment: how market, policy, and climate transformations affect forests -- Proceedings of the 2016 Meeting of the International Society of Forest Resource Economics

    Science.gov (United States)

    Gregory E. Frey; Prakash Nepal

    2016-01-01

    Economics can affect decisions about forest resource management and utilization, and in turn, the ecosystem benefits received. In a time of market, policy, and climate transformations, economic analyses are critical to help policy-makers and resource managers make appropriate decisions. At the 2016 Meeting of the International Society of Forest Resource Economics (...

  10. The International Database of Efficient Appliances (IDEA): A New Resource for Global Efficiency Policy

    Energy Technology Data Exchange (ETDEWEB)

    Gerke, Brian F; McNeil, Michael A; Tu, Thomas; Xu, Feiyang

    2017-09-06

    A major barrier to effective appliance efficiency program design and evaluation is a lack of data for determination of market baselines and cost-effective energy savings potential. The data gap is particularly acute in developing countries, which may have the greatest savings potential per unit GDP. To address this need, we are developing the International Database of Efficient Appliances (IDEA), which automatically compiles data from a wide variety of online sources to create a unified repository of information on efficiency, price, and features for a wide range of energy-consuming products across global markets. This paper summarizes the database framework and demonstrates the power of IDEA as a resource for appliance efficiency research and policy development. Using IDEA data for refrigerators in China and India, we develop robust cost-effectiveness indicators that allow rapid determination of savings potential within each market, as well as comparison of that potential across markets and appliance types. We discuss implications for future energy efficiency policy development.

  11. Policy Design for Competitive Retail Electric Institutions: Artificial Intelligence Representations for a Common Property Resource Approach

    Science.gov (United States)

    Pandit, Nitin S.

    The U.S. electricity industry is being restructured to increase competition. Although existing policies may lead to efficient wholesale institutions, designing policies for the retail level is more complex because of intricate interactions between individuals and quasi-monopolistic institutions. It is argued that Hirshman's ideas of "exit" and "voice" (Hirshman, 1970) provide powerful abstractions for design of retail institutions. While competition is a known mechanism of "exit," a novel design of the "voice" mechanism is demonstrated through an artificial intelligence (AI) based software process model. The process model of "voice" in retail institutions is designed within the economic context of electricity distribution -- a common property resource (CPR), characterized by technological uncertainty and path-dependency. First, it is argued that participant feedback (voice) has to be used effectively to manage the CPR. Further, it is noted that the decision process, of using participant feedback (voice) to incrementally manage uncertainty and path-dependencies, is non-monotonic because it requires the decision makers to often retract previously made assumptions and decisions. An AI based process model of "voice" is developed using an assumption-based truth maintenance system. The model can emulate the non-monotonic decision making process and therefore assist in decision support. Such a systematic framework is flexible, consistent, and easily reorganized as assumptions change. It can provide an effective, formal "voice" mechanism to the retail customers and improve institutional performance.

  12. Wind deployment in the United States: states, resources, policy, and discourse.

    Science.gov (United States)

    Wilson, Elizabeth J; Stephens, Jennie C

    2009-12-15

    A transformation in the way the United States produces and uses energy is needed to achieve greenhouse gas reduction targets for climate change mitigation. Wind power is an important low-carbon technology and the most rapidly growing renewable energy technology in the U.S. Despite recent advances in wind deployment, significant state-by-state variation in wind power distribution cannot be explained solely by wind resource patterns nor by state policy. Other factors embedded within the state-level socio-political context also contribute to wind deployment patterns. We explore this socio-political context in four U.S. states by integrating multiple research methods. Through comparative state-level analysis of the energy system, energy policy, and public discourse as represented in the media, we examine variation in the context for wind deployment in Massachusetts, Minnesota, Montana, and Texas. Our results demonstrate that these states have different patterns of wind deployment, are engaged in different debates about wind power, and appear to frame the risks and benefits of wind power in different ways. This comparative assessment highlights the complex variation of the state-level socio-political context and contributes depth to our understanding of energy technology deployment processes, decision-making, and outcomes.

  13. Discharge Fee Policy Analysis: A Computable General Equilibrium (CGE Model of Water Resources and Water Environments

    Directory of Open Access Journals (Sweden)

    Guohua Fang

    2016-09-01

    Full Text Available To alleviate increasingly serious water pollution and shortages in developing countries, various kinds of policies have been implemented by local governments. It is vital to quantify and evaluate the performance and potential economic impacts of these policies. This study develops a Computable General Equilibrium (CGE model to simulate the regional economic and environmental effects of discharge fees. Firstly, water resources and water environment factors are separated from the input and output sources of the National Economic Production Department. Secondly, an extended Social Accounting Matrix (SAM of Jiangsu province is developed to simulate various scenarios. By changing values of the discharge fees (increased by 50%, 100% and 150%, three scenarios are simulated to examine their influence on the overall economy and each industry. The simulation results show that an increased fee will have a negative impact on Gross Domestic Product (GDP. However, waste water may be effectively controlled. Also, this study demonstrates that along with the economic costs, the increase of the discharge fee will lead to the upgrading of industrial structures from a situation of heavy pollution to one of light pollution which is beneficial to the sustainable development of the economy and the protection of the environment.

  14. HIV self-testing in resource-limited settings: regulatory and policy considerations.

    Science.gov (United States)

    Wong, Vincent; Johnson, Cheryl; Cowan, Elliot; Rosenthal, Matthew; Peeling, Rosanna; Miralles, Maria; Sands, Anita; Brown, Charlene

    2014-07-01

    HIV self-testing (HIVST) is an emerging HIV testing strategy intended to address challenges of increasing access to preliminary knowledge of serostatus. It offers the potential for tests and testing to reach more people than previously possible, including those who do not seek testing in facilities. With approval of an HIV self-test kit in the USA, increasing evidence from public pilot programs in sub-Saharan Africa showing high acceptability and feasibility, and evidence of the informal sale of rapid HIV test kits in the private sector, options for individuals to access HIV self-testing, as well as consumer-demand, appear to be increasing. More recently WHO and UNAIDS have explored self-testing as an option to achieving greater HIV testing coverage to support global treatment targets. However, for resource-limited settings, technological development, diagnostic device regulation and quality assurance policies are lagging behind. This commentary will examine regulatory and policy issues with HIVST, given its increased prominence as a potential part of the global HIV/AIDS response.

  15. Integrated resource planning for local gas distribution companies: A critical review of regulatory policy issues

    Energy Technology Data Exchange (ETDEWEB)

    Harunuzzaman, M.; Islam, M.

    1994-08-01

    According to the report, public utility commissions (PUCs) are increasingly adopting, or considering the adoption of integrated resource planning (IRP) for local gas distribution companies (LDCs). The Energy Policy Act of 1992 (EPAct) requires PUCs to consider IRP for gas LDCs. This study has two major objectives: (1) to help PUCs develop appropriate regulatory approaches with regard to IRP for gas LDCs; and (2) to help PUCs respond to the EPAct directive. The study finds that it is appropriate for PUCs to pursue energy efficiency within the traditional regulatory framework of minimizing private costs of energy production and delivery; and PUCs should play a limited role in addressing environmental externalities. The study also finds that in promoting energy efficiency, PUCs should pursue policies that are incentive-based, procompetitive, and sensitive to rate impacts. The study evaluates a number of traditional and nontraditional ratemaking mechanisms on the basis of cost minimization, energy efficiency, competitiveness, and other criteria. The mechanisms evaluated include direct recovery of DSM expenses, lost revenue adjustments for DSM options, revenue decoupling mechanisms, sharing of DSM cost savings, performance-based rate of return for DSM, provision of DSM as a separate service, deregulation of DSM service, price caps, and deregulation of the noncore gas market. The study concludes with general recommendations for regulatory approaches and ratemaking mechanisms that PUCs may wish to consider in advancing IRP objectives.

  16. Integrated resource planning for local gas distribution companies: A critical review of regulatory policy issues

    International Nuclear Information System (INIS)

    Harunuzzaman, M.; Islam, M.

    1994-08-01

    According to the report, public utility commissions (PUCs) are increasingly adopting, or considering the adoption of integrated resource planning (IRP) for local gas distribution companies (LDCs). The Energy Policy Act of 1992 (EPAct) requires PUCs to consider IRP for gas LDCs. This study has two major objectives: (1) to help PUCs develop appropriate regulatory approaches with regard to IRP for gas LDCs; and (2) to help PUCs respond to the EPAct directive. The study finds that it is appropriate for PUCs to pursue energy efficiency within the traditional regulatory framework of minimizing private costs of energy production and delivery; and PUCs should play a limited role in addressing environmental externalities. The study also finds that in promoting energy efficiency, PUCs should pursue policies that are incentive-based, procompetitive, and sensitive to rate impacts. The study evaluates a number of traditional and nontraditional ratemaking mechanisms on the basis of cost minimization, energy efficiency, competitiveness, and other criteria. The mechanisms evaluated include direct recovery of DSM expenses, lost revenue adjustments for DSM options, revenue decoupling mechanisms, sharing of DSM cost savings, performance-based rate of return for DSM, provision of DSM as a separate service, deregulation of DSM service, price caps, and deregulation of the noncore gas market. The study concludes with general recommendations for regulatory approaches and ratemaking mechanisms that PUCs may wish to consider in advancing IRP objectives

  17. The effect of natural resources on a sustainable development policy: The approach of non-sustainable externalities

    International Nuclear Information System (INIS)

    Schilling, Markus; Chiang Lichun

    2011-01-01

    The debate about the importance of non-renewable resources for economic development between optimists and pessimists shows that the extensive depletion of non-renewable resources, particularly oil, along with a higher level of consumption could have a significant impact on the economic development of future generations. Based on this debate, this paper proposes criteria under which the depletion of non-renewable resources would create excess costs for future generations. Therefore, this paper aims to answer the question 'What will be the impact of the depletion of non-renewable resources on sustainable economic development?' Accordingly, a sustainable development policy appears feasible by minimizing non-sustainable externalities which derive from future externalities that weigh the benefits from a previous employment of natural resources. The research based on qualitative analysis clarifies the reasons for and the extents of taking sustainability into account as well as points to difficulties of implementing policies to time the transition towards a sustainable economic development. Finally, the research shows the implications of this approach for environmental degradation, the depletion of non-renewable resources and energy production. - Research Highlights: →Economic development will more or less smoothly switch to the use of renewable substitutes. →The transition towards a sustainable use of resources may inherit costs for future generations. →Non-sustainable externalities show the future costs of excessive resource depletion. →The approach aims to take the long-term global effects of resource substitution into account.

  18. Human resources for health and decentralization policy in the Brazilian health system.

    Science.gov (United States)

    Pierantoni, Celia Regina; Garcia, Ana Claudia P

    2011-05-17

    The Brazilian health reform process, following the establishment of the Unified Health System (SUS), has had a strong emphasis on decentralization, with a special focus on financing, management and inter-managerial agreements. Brazil is a federal country and the Ministry of Health (MoH), through the Secretary of Labour Management and Health Education, is responsible for establishing national policy guidelines for health labour management, and also for implementing strategies for the decentralization of management of labour and education in the federal states. This paper assesses whether the process of decentralizing human resources for health (HRH) management and organization to the level of the state and municipal health departments has involved investments in technical, political and financial resources at the national level. The research methods used comprise a survey of HRH managers of states and major municipalities (including capitals) and focus groups with these HRH managers - all by geographic region. The results were obtained by combining survey and focus group data, and also through triangulation with the results of previous research. The results of this evaluation showed the evolution policy, previously restricted to the field of 'personnel administration', now expanded to a conceptual model for health labour management and education-- identifying progress, setbacks, critical issues and challenges for the consolidation of the decentralized model for HRH management. The results showed that 76.3% of the health departments have an HRH unit. It was observed that 63.2% have an HRH information system. However, in most health departments, the HRH unit uses only the payroll and administrative records as data sources. Concerning education in health, 67.6% of the HRH managers mentioned existing cooperation with educational and teaching institutions for training and/or specialization of health workers. Among them, specialization courses account for 61.4% and short

  19. Human resources for health and decentralization policy in the Brazilian health system

    Directory of Open Access Journals (Sweden)

    Pierantoni Celia

    2011-05-01

    Full Text Available Abstract Background The Brazilian health reform process, following the establishment of the Unified Health System (SUS, has had a strong emphasis on decentralization, with a special focus on financing, management and inter-managerial agreements. Brazil is a federal country and the Ministry of Health (MoH, through the Secretary of Labour Management and Health Education, is responsible for establishing national policy guidelines for health labour management, and also for implementing strategies for the decentralization of management of labour and education in the federal states. This paper assesses whether the process of decentralizing human resources for health (HRH management and organization to the level of the state and municipal health departments has involved investments in technical, political and financial resources at the national level. Methods The research methods used comprise a survey of HRH managers of states and major municipalities (including capitals and focus groups with these HRH managers - all by geographic region. The results were obtained by combining survey and focus group data, and also through triangulation with the results of previous research. Results The results of this evaluation showed the evolution policy, previously restricted to the field of 'personnel administration', now expanded to a conceptual model for health labour management and education-- identifying progress, setbacks, critical issues and challenges for the consolidation of the decentralized model for HRH management. The results showed that 76.3% of the health departments have an HRH unit. It was observed that 63.2% have an HRH information system. However, in most health departments, the HRH unit uses only the payroll and administrative records as data sources. Concerning education in health, 67.6% of the HRH managers mentioned existing cooperation with educational and teaching institutions for training and/or specialization of health workers. Among them

  20. REGULATORY POLICY AND OPTIMIZATION OF INVESTMENT RESOURCE ALLOCATION IN THE MODEL OF FUNCTIONING OF RECREATION INDUSTRY

    Directory of Open Access Journals (Sweden)

    Hanna Shevchenko

    2017-11-01

    Full Text Available The research objective is the rationale of the theoretical and methodical approach concerning the improvement of regulatory policy as well as the process of distribution of financial investments using the model of the functioning of a recreational sector of the national economy. The methodology of the study includes the use of optimal control theory for the model formation of the functioning of the recreational industry as well as determining the behaviour of regulatory authorities and capabilities to optimize the allocation of investment resources in the recreational sector of the national economy. Results. The issue of equilibration of regulatory policy in the recreational sector of the national economy is actualized, including the question of targeted distribution of state and external financial investments. Also, it is proved that regulatory policy should establish the frameworks that on the one hand, do not allow public authorities to exercise extra influence on the economy of recreation, on the other hand, to keep the behaviour of the recreational business entities within the limits of normal socio-economic activity – on the basis of analysis of the continuum “recreation – work” by means of modified Brennan-Buchanan model. It is revealed that even with the condition of the tax reduction, the situation when the population resting less and works more than in the background of a developed economy is observed. However, according to the optimistic forecast, eventually on condition when the economy is emerging from the shade, we will obtain an official mode of the work in which, while maintaining taxes on proposed more advantageous for the population level, ultimately the ratio leisure and work will be established which is corresponding to the principles of sustainable development. Practical value. On the basis of methodical principles of the theory of optimal control, the model of the functioning of the recreational industry under the

  1. Soils, people and policy: land resource management conundrum in the Okavango Delta, Botswana

    Directory of Open Access Journals (Sweden)

    Oluwatoyin Dare Kolawole

    2017-06-01

    Full Text Available The multi-faceted aspects of natural resource governance underscore the complex nature of the subject. The intricacies associated with the skewed power relations between those who allocate these resources (land, in this case and those who access and use them vis à vis environmental conservation make the subject a daunting one. Based on preliminary field observations and farmers’ opinions on soil health conditions in the Okavango Delta, the paper assesses the nutrient status of selected farmers’ fields and how the smallholders and government respond to this peculiar ecological environment. It specifically analyses small farmers’ perceptions on the political ecology of soil management in the area. We used a multi-stage sampling procedure to sample 228 smallholder farmers. The smallholders were interviewed using interview schedules. Key informant interviews were used to collect qualitative data from farmers as well. Thirty-three (33 composite soil samples were collected from 30 farmers’ plots in three farming communities (Makalamabedi, Nokaneng and Mohembo. Laboratory analysis shows that most soils in the wetland and its dryland surroundings are generally acidic, low in essential nutients as well as in cation-exchange-capacity (CEC. However, the results of a one-way analysis of variance (ANOVA conducted shows significant differences in soil nutrient levels in different locations within the Delta. While farming remains an important livelihood of rural communities, policies on natural resource governance particularly along the river channels delimit local farmers’ ability to engage in meaningful soil fertility management. The low CEC of the soils is an indication that holistic cultural practices, which are beyond mere chemical fertilizations are critical and more desirable for improved soil health and sustainable rural livelihoods in the Delta.

  2. A qualitative exploration of the human resource policy implications of voluntary counselling and testing scale-up in Kenya: applying a model for policy analysis

    Science.gov (United States)

    2011-01-01

    Background Kenya experienced rapid scale up of HIV testing and counselling services in government health services from 2001. We set out to examine the human resource policy implications of scaling up HIV testing and counselling in Kenya and to analyse the resultant policy against a recognised theoretical framework of health policy reform (policy analysis triangle). Methods Qualitative methods were used to gain in-depth insights from policy makers who shaped scale up. This included 22 in-depth interviews with Voluntary Counselling and Testing (VCT) task force members, critical analysis of 53 sets of minutes and diary notes. We explore points of consensus and conflict amongst policymakers in Kenya and analyse this content to assess who favoured and resisted new policies, how scale up was achieved and the importance of the local context in which scale up occurred. Results The scale up of VCT in Kenya had a number of human resource policy implications resulting from the introduction of lay counsellors and their authorisation to conduct rapid HIV testing using newly introduced rapid testing technologies. Our findings indicate that three key groups of actors were critical: laboratory professionals, counselling associations and the Ministry of Health. Strategic alliances between donors, NGOs and these three key groups underpinned the process. The process of reaching consensus required compromise and time commitment but was critical to a unified nationwide approach. Policies around quality assurance were integral in ensuring standardisation of content and approach. Conclusion The introduction and scale up of new health service initiatives such as HIV voluntary counselling and testing necessitates changes to existing health systems and modification of entrenched interests around professional counselling and laboratory testing. Our methodological approach enabled exploration of complexities of scale up of HIV testing and counselling in Kenya. We argue that a better

  3. Development of a spatial planning support system for agricultural policy formulation related to land and water resources in Borkhar & Meymeh district, Iran

    NARCIS (Netherlands)

    Farhadi Bansouleh, B.F.

    2009-01-01

    In this study, a system was developed to support agricultural planners and policy makers in land resource analysis, policy formulation, identification of possible policy measures and policy impact analysis. The research is part of a larger programme, aiming at development of a model system to

  4. Development of a spatial planning support system for agricultural policy formulation related to land and water resources in Borkhar & Meymeh district, Iran

    NARCIS (Netherlands)

    Farhadi Bansouleh, B.F.

    2009-01-01

    In this study, a system was developed to support agricultural planners and
    policy makers in land resource analysis, policy formulation, identification of
    possible policy measures and policy impact analysis. The research is part of a
    larger programme, aiming at development of a

  5. Factors that influence human resources for health policy formulation: a multiple case study in Brazil and Portugal.

    Science.gov (United States)

    Oliveira, Ana Paula Cavalcante de; Poz, Mario Roberto Dal; Craveiro, Isabel; Gabriel, Mariana; Dussault, Gilles

    2018-03-01

    This study aims to analyze whether the process by which policies for human resources for health that aim to improve the geographic distribution of physicians have been informed by scientific evidence in Brazil and Portugal. This was a multiple case study on a decision-making process for human resources for health in Brazil and Portugal. The respective case studies were based on Brazil's More Doctors Program (Programa Mais Médicos - PMM) and Portugal's strategy of hiring foreign physicians through bilateral agreements, to work in the country's National Health Service (SNS). We interviewed 27 key actors in the policy-making process on the following topics: factors that influenced the policy decisions, actors that were expected to win or lose from the policy, and the scientific evidence and available data used in the policy-making, among others. The most evident factors appearing in the interviews as having influenced the PMM were: institutions; external factors (Presidential elections); group interests (e.g. physicians' professional associations), governments (Brazil and Cuba), international organizations, and civil society; and ideas (scientific evidence). The most frequently cited factors in Portugal were: institutions and interests of government (from Portugal and the countries involved in the bilateral agreements), civil society, and groups (physicians' professional associations). Contrary to the case study in Brazil, where the evidence was reported to having played an important role in the policy decisions, in Portugal, scientific evidence was not identified as contributing to the specific policy process.

  6. The Heritage of Earth Science Applications in Policy, Business, and Management of Natural Resources

    Science.gov (United States)

    Macauley, M.

    2012-12-01

    From the first hand-held cameras on the Gemini space missions to present day satellite instruments, Earth observations have enhanced the management of natural resources including water, land, and air. Applications include the development of new methodology (for example, developing and testing algorithms or demonstrating how data can be used) and the direct use of data in decisionmaking and policy implementation. Using well-defined bibliographic search indices to systematically survey a broad social science literature, this project enables identification of a host of well-documented, practical and direct applications of Earth science data in resource management. This literature has not previously been well surveyed, aggregated, or analyzed for the heritage of lessons learned in practical application of Earth science data. In the absence of such a survey, the usefulness of Earth science data is underestimated and the factors that make people want to use -- and able to use -- the data are poorly understood. The project extends and updates previous analysis of social science applications of Landsat data to show their contemporary, direct use in new policy, business, and management activities and decisionmaking. The previous surveys (for example, Blumberg and Jacobson 1997; National Research Council 1998) find that the earliest attempts to use data are almost exclusively testing of methodology rather than direct use in resource management. Examples of methodology prototyping include Green et al. (1997) who demonstrate use of remote sensing to detect and monitor changes in land cover and use, Cowen et al. (1995) who demonstrate design and integration of GIS for environmental applications, Hutchinson (1991) who shows uses of data for famine early warning, and Brondizio et al. (1996) who show the link of thematic mapper data with botanical data. Blumberg and Jacobson (in Acevedo et al. 1996) show use of data in a study of urban development in the San Francisco Bay and the

  7. Strategies to enhance the impact of research on human resources for health on policy making

    Directory of Open Access Journals (Sweden)

    Taghreed Adam

    2011-06-01

    Full Text Available Despite global recognition of the importance of human resources for health (HRH in achieving health system goals, very little is known about what works, for whom and under what circumstances, especially for low-income and middleincome countries. Several important events and reports have called for increased funding and capacity for HRH research in recent years and several initiatives have started as a result. Progress has been slow, however. The following strategies can be most valuable in ensuring the relevance of the generated evidence for decision making and its contribution to stronger health systems. The first is to promote national processes to set priorities for HRH research with active participation from decision makers. The second is to make conscious efforts to scale up primary research to address priority questions and to develop sustainable mechanisms to evaluate the impact of current or new HRH strategies to feed into the policy making process. The third is to invest in the development of systematic reviews to synthesize available evidence and in the adaptation of the underlying methods to make them more responsive to the type of questions and the nature of research involving HRH issues. The fourth and most important is to consistently use a systems approach in framing and addressing research questions. While a narrow approach may be more attractive and simple, health systems and the problems facing them are not. Increasing the body of evidence that takes into account the complexity of health systems, and particularly human resources for health, will advance knowledge in this area and will make big strides in the quality and usefulness of the generated evidence.

  8. An Integrated Systems Approach to Designing Climate Change Adaptation Policy in Water Resources

    Science.gov (United States)

    Ryu, D.; Malano, H. M.; Davidson, B.; George, B.

    2014-12-01

    Climate change projections are characterised by large uncertainties with rainfall variability being the key challenge in designing adaptation policies. Climate change adaptation in water resources shows all the typical characteristics of 'wicked' problems typified by cognitive uncertainty as new scientific knowledge becomes available, problem instability, knowledge imperfection and strategic uncertainty due to institutional changes that inevitably occur over time. Planning that is characterised by uncertainties and instability requires an approach that can accommodate flexibility and adaptive capacity for decision-making. An ability to take corrective measures in the event that scenarios and responses envisaged initially derive into forms at some future stage. We present an integrated-multidisciplinary and comprehensive framework designed to interface and inform science and decision making in the formulation of water resource management strategies to deal with climate change in the Musi Catchment of Andhra Pradesh, India. At the core of this framework is a dialogue between stakeholders, decision makers and scientists to define a set of plausible responses to an ensemble of climate change scenarios derived from global climate modelling. The modelling framework used to evaluate the resulting combination of climate scenarios and adaptation responses includes the surface and groundwater assessment models (SWAT & MODFLOW) and the water allocation modelling (REALM) to determine the water security of each adaptation strategy. Three climate scenarios extracted from downscaled climate models were selected for evaluation together with four agreed responses—changing cropping patterns, increasing watershed development, changing the volume of groundwater extraction and improving irrigation efficiency. Water security in this context is represented by the combination of level of water availability and its associated security of supply for three economic activities (agriculture

  9. Czech Rural Development Policies for Human Resources, post-2004: A Story of Muddled Definitions Preventing Strategic Visions?"

    Czech Academy of Sciences Publication Activity Database

    Vobecká, Jana

    2009-01-01

    Roč. 3, č. 1 (2009), s. 44-65 ISSN 1802-4866 R&D Projects: GA MŠk 2D06006 Institutional research plan: CEZ:AV0Z70280505 Keywords : rural development * human resources * policy formulation Subject RIV: AD - Politology ; Political Sciences

  10. Kenya's health workforce information system: a model of impact on strategic human resources policy, planning and management.

    Science.gov (United States)

    Waters, Keith P; Zuber, Alexandra; Willy, Rankesh M; Kiriinya, Rose N; Waudo, Agnes N; Oluoch, Tom; Kimani, Francis M; Riley, Patricia L

    2013-09-01

    Countries worldwide are challenged by health worker shortages, skill mix imbalances, and maldistribution. Human resources information systems (HRIS) are used to monitor and address these health workforce issues, but global understanding of such systems is minimal and baseline information regarding their scope and capability is practically non-existent. The Kenya Health Workforce Information System (KHWIS) has been identified as a promising example of a functioning HRIS. The objective of this paper is to document the impact of KHWIS data on human resources policy, planning and management. Sources for this study included semi-structured interviews with senior officials at Kenya's Ministry of Medical Services (MOMS), Ministry of Public Health and Sanitation (MOPHS), the Department of Nursing within MOMS, the Nursing Council of Kenya, Kenya Medical Practitioners and Dentists Board, Kenya's Clinical Officers Council, and Kenya Medical Laboratory Technicians and Technologists Board. Additionally, quantitative data were extracted from KHWIS databases to supplement the interviews. Health sector policy documents were retrieved from MOMS and MOPHS websites, and reviewed to assess whether they documented any changes to policy and practice as having been impacted by KHWIS data. Interviews with Kenyan government and regulatory officials cited health workforce data provided by KHWIS influenced policy, regulation, and management. Policy changes include extension of Kenya's age of mandatory civil service retirement from 55 to 60 years. Data retrieved from KHWIS document increased relicensing of professional nurses, midwives, medical practitioners and dentists, and interviewees reported this improved compliance raised professional regulatory body revenues. The review of Government records revealed few references to KHWIS; however, documentation specifically cited the KHWIS as having improved the availability of human resources for health information regarding workforce planning

  11. Policy Recommendations for the Argentinean Water Resources National Plan Related to Extreme Events in Forested Mountain Basins.

    Science.gov (United States)

    Urciuolo, A. B.; Iturraspe, R. J.; Lofiego, R.

    2007-05-01

    In the framework of activities developed by COHIFE (Federal Water Resource Council), Argentina is preparing the Water Resources National Plan. To achieve an integrating project and considering that Argentina is a federal country, each province is working on the basis of its own Water Resources Provincial Plan. The first step of the plan consists in the identification of problems, with the purpose of further defining solutions based on structural and non structural actions. The general perception of the stakeholders involved in the plan development is the necessity of the analysis of strategies for the integrated water resource management Although a first document for water policy, named "Principios Rectores de Política Hídrica" is available, there are not specific strategies for integrated management of water and land use oriented to extreme events. In other way, there are a lack of policies oriented to Mountain basin with forest coverage, may be because of most of the population and the economical structure of the country is located on plain regions. This article proposes recommendations for policy to be integrated to the Water Resources National Plan, based on studies developed in a pilot basin representative of the Andean-Patagonia eco-region, in the framework of the EPIC FORCE proyect, financed by the European Union. Project methodology includes basin instrumentation, reconstruction and analysis of extreme events and land-water management practices revision. Climate, flow and sediment Data are available for simulation using the Shetran model on different land use scenarios, including changes in the basin forest coverage. On the basis of the first results of the project, policy guides oriented to fill mentioned policy lacks were defined.

  12. Combined Methods for Quantifying Uncertainty of Regional Climate Change for Use in Policy and Resources Management

    Science.gov (United States)

    Mearns, L. O.; Tebaldi, C.

    2006-12-01

    Over tha past few years, methods for quantifying uncertainty in regional climate change have seen an upswing in development, and this was greatly facilitated by the creation of a relatively large multi-member ensemble of coupled climate model runs for the Fourth Assessment of the IPCC. Usually the rationale for developing such probabilistic methods is for use by impacts researchers, policy makers, and resource managers, to aid in their decision making. While these developments have been welcome, it is clear that probabilisitc information developed in a Bayesian framework, alone will not suffice for providng levels of confidence in the future projections. While some of the methods have attempted to weight the members of multi-model ensembles by evaluating how well the models reproduce current climate, so far these methods have been overly simplistic. It may well be that qualitative information regarding the model's reproduction of critical processes that determine the climate of a particular region needs to be considered along with probabilistic information. We discuss how these different types of information (qualitative process-based and probability density functions) could be combined to provide a more complete assessment of how confident we should be regarding regional cliamte change. measure of uncertainty for regional scale climate change.

  13. Specific Modifications to Contract Policy for Staff Members and Project Associates related to the Human Resources Plan and LHC Completion

    CERN Document Server

    2003-01-01

    As agreed at the Committee meetings last December, the Management hereby submits two specific proposals to adjust staff contract policy and a third concerning appointments of Project Associates, following indications given in the Human Resources Plan presented last December. These proposals are limited to changes which are urgently required for the implementation of the HR Plan and the completion of the LHC. Other aspects concerning contract policy, raised by Internal Task Force 4 last year, and in particular the policy and procedures governing the award of indefinite contracts, require more in-depth study on which the Management will report progress on the clarification of these wider policy issues later in the year to TREF. After discussion at TREF in February 2003, the Management hereby submits these proposals for approval by the Finance Committee (paragraph 2.1 below) and by the Council (paragraphs 2.2 and 3.1 below), for entry into force on 1 April 2003.

  14. Waste cooking oil as an energy resource: review of Chinese policies

    OpenAIRE

    Zhang, Huiming; Wang, Qunwei; Mortimer, Simon R.

    2012-01-01

    Converting waste cooking oil into biofuel represents a three-win solution, dealing simultaneously with food security, pollution, and energy security. In this paper, we encode the policy documents of waste cooking oil refining biofuel in China based on content analysis, and explore the related policies from the two dimensions as basic policy tools and enterprises supply chain. Research indicates the weak institution coordination of policy issuing entities. Also, the findings show that tools of...

  15. 76 FR 26235 - EPAAR Clause for Compliance with EPA Policies for Information Resources Management

    Science.gov (United States)

    2011-05-06

    ... Protection Agency (EPA) amends the EPA Acquisition Regulation (EPAAR) to update policy, procedures, and... under this contract in accordance with the IRM policies, standards, and procedures set forth on the... Agency's IRM policies, standards, and procedures. (c) Section 508 Requirements. Contract deliverables are...

  16. Struggling between resources-based and sustainable development schemes-An analysis of Egypt's recent energy policy

    International Nuclear Information System (INIS)

    Suding, Paul H.

    2011-01-01

    This paper discusses Egypt's recent energy sector and policy developments against objectives and issues of the energy policy strategy adopted in 2007. It reviews energy supply and demand, pricing and subsidies as well as institutional arrangements and respective reform projects from the perspective of assessing achievements. It identifies the consequences of the policy and the long-term outlook and reports on the internal policy struggle. The policy strategy of 2007 is directed at energy security, social and industrial development. Environmental or climate objectives play no role. Energy efficiency is at best considered an instrument. The implementation of the strategy has been successful on the supply side, but not on the demand side. Price reform, refocusing subsidies and sector reform were not achieved. This has negatively affected energy efficiency and diversification, energy availability and supply security, the State budget and the sector's financial capacity. It causes rising energy import requirements and increasing risks to the current account balance. In spite of that, 'old guard' and industrial establishment favour the resource-based development based on cheap energy and protract price reform, whereas another group of businessmen wants a sustainable development concept and monetize the oil and gas production to invest in Egypt's competitiveness. - Research Highlights: → Egyptian energy policy has not delivered demand side results and institutional reform. → The consequences are disparities in supply, external balance, financing and subsidies. →The prevailing interest groups succeed in protracting the implementation of the policy.

  17. Mental health research in Brazil: policies, infrastructure, financing and human resources

    Directory of Open Access Journals (Sweden)

    Mari Jair de Jesus

    2006-01-01

    Full Text Available The objective of this descriptive study was to map mental health research in Brazil, providing an overview of infrastructure, financing and policies mental health research. As part of the Atlas-Research Project, a WHO initiative to map mental health research in selected low and middle-income countries, this study was carried out between 1998 and 2002. Data collection strategies included evaluation of governmental documents and sites and questionnaires sent to key professionals for providing information about the Brazilian mental health research infrastructure. In the year 2002, the total budget for Health Research was US$101 million, of which US$3.4 million (3.4 was available for Mental Health Research. The main funding sources for mental health research were found to be the São Paulo State Funding Agency (Fapesp, 53.2% and the Ministry of Education (CAPES, 30.2%. The rate of doctors is 1.7 per 1,000 inhabitants, and the rate of psychiatrists is 2.7 per 100,000 inhabitants estimated 2000 census. In 2002, there were 53 postgraduate courses directed to mental health training in Brazil (43 in psychology, six in psychiatry, three in psychobiology and one in psychiatric nursing, with 1,775 students being trained in Brazil and 67 overseas. There were nine programs including psychiatry, neuropsychiatry, psychobiology and mental health, seven of them implemented in Southern states. During the five-year period, 186 students got a doctoral degree (37 per year and 637 articles were published in Institute for Scientic Information (ISI-indexed journals. The investment channeled towards postgraduate and human resource education programs, by means of grants and other forms of research support, has secured the country a modest but continuous insertion in the international knowledge production in the mental health area.

  18. Mental health research in Brazil: policies, infrastructure, financing and human resources

    Directory of Open Access Journals (Sweden)

    Jair de Jesus Mari

    2006-02-01

    Full Text Available The objective of this descriptive study was to map mental health research in Brazil, providing an overview of infrastructure, financing and policies mental health research. As part of the Atlas-Research Project, a WHO initiative to map mental health research in selected low and middle-income countries, this study was carried out between 1998 and 2002. Data collection strategies included evaluation of governmental documents and sites and questionnaires sent to key professionals for providing information about the Brazilian mental health research infrastructure. In the year 2002, the total budget for Health Research was US$101 million, of which US$3.4 million (3.4 was available for Mental Health Research. The main funding sources for mental health research were found to be the São Paulo State Funding Agency (Fapesp, 53.2% and the Ministry of Education (CAPES, 30.2%. The rate of doctors is 1.7 per 1,000 inhabitants, and the rate of psychiatrists is 2.7 per 100,000 inhabitants estimated 2000 census. In 2002, there were 53 postgraduate courses directed to mental health training in Brazil (43 in psychology, six in psychiatry, three in psychobiology and one in psychiatric nursing, with 1,775 students being trained in Brazil and 67 overseas. There were nine programs including psychiatry, neuropsychiatry, psychobiology and mental health, seven of them implemented in Southern states. During the five-year period, 186 students got a doctoral degree (37 per year and 637 articles were published in Institute for Scientic Information (ISI-indexed journals. The investment channeled towards postgraduate and human resource education programs, by means of grants and other forms of research support, has secured the country a modest but continuous insertion in the international knowledge production in the mental health area.

  19. Sectoral Heterogeneity, Resource Depletion, and Directed Technical Change: Theory and Policy

    OpenAIRE

    Pittel, Karen; Bretschger, Lucas

    2008-01-01

    We analyze an economy in which sectors are heterogeneous with respect to the intensity of natural resource use. Long-term dynamics are driven by resource prices, sectoral composition, and directed technical change. We study the balanced growth path and determine stability conditions. Technical change is found to be biased towards the resource-intensive sector. Resource taxes have no impact on dynamics except when the tax rate varies over time. Constant research subsidies raise the growth rate...

  20. Global Concerns and Renewable Energy Policies: The Use of Regional Vegetal Resources to Create Growth Zones in Developing Countries

    OpenAIRE

    Fernando do Rego Barros Filho

    2010-01-01

    In a legal framework that must respect the ecologic balance, the economic viability, social inclusion and culture preservation, this study focuses on the efficiency of the Brazilian National Program of Biodiesel. The context shown below is the program´s capability of developing isolated regions of the country characterized by lack of conventional energy policies, rich culture aspects, poverty and the possibility of producing energy by its natural resources and species. The results demonstrate...

  1. Examining Charter School Policy and Public School District Resource Allocation in Ohio

    Science.gov (United States)

    Linick, Matthew A.

    2016-01-01

    This project focuses on the competitive pressure, or the threat of competitive pressure, generated by charter school policy. This paper uses longitudinal district-level data and multiple quasi-experimental designs to examine the relationship between two Ohio charter school policies and changes in public school district instructional resource…

  2. Policies and practices of countries experiencing a crisis in Human Resources for Health : A tracking survey

    NARCIS (Netherlands)

    van den Broek, Ankie; Gedik, Gulin; dal Poz, Mario; Dieleman, M.A.

    2010-01-01

    In order to understand and monitor the progress in developing and implementing HRH policies in the 57 countries experiencing a critical deficit in the health workforce, this tracking survey provides an overview of the current situation in terms of HRH policies, plans, capacities and processes. The

  3. Information technology in veterinary pharmacology instruction.

    Science.gov (United States)

    Kochevar, Deborah T

    2003-01-01

    Veterinary clinical pharmacology encompasses all interactions between drugs and animals and applies basic and clinical knowledge to improve rational drug use and patient outcomes. Veterinary pharmacology instructors set educational goals and objectives that, when mastered by students, lead to improved animal health. The special needs of pharmacology instruction include establishing a functional interface between basic and clinical knowledge, managing a large quantity of information, and mastering quantitative skills essential to successful drug administration and analysis of drug action. In the present study, a survey was conducted to determine the extent to which veterinary pharmacology instructors utilize information technology (IT) in their teaching. Several IT categories were investigated, including Web-based instructional aids, stand-alone pharmacology software, interactive videoconferencing, databases, personal digital assistants (PDAs), and e-book applications. Currently IT plays a largely ancillary role in pharmacology instruction. IT use is being expanded primarily through the efforts of two veterinary professional pharmacology groups, the American College of Veterinary Clinical Pharmacology (ACVCP) and the American Academy of Veterinary Pharmacology and Therapeutics (AAVPT). The long-term outcome of improved IT use in pharmacology instruction should be to support the larger educational mission of active learning and problem solving. Creation of high-quality IT resources that promote this goal has the potential to improve veterinary pharmacology instruction within and across institutions.

  4. Resources

    Science.gov (United States)

    English in Australia, 1973

    1973-01-01

    Contains seven short resources''--units, lessons, and activities on the power of observation, man and his earth, snakes, group discussion, colloquial and slang, the continuous story, and retelling a story. (DD)

  5. Relevance of national and local government policy to sustainable community natural resource management in South Africa

    CSIR Research Space (South Africa)

    Musvoto, Constansia D

    2011-12-01

    Full Text Available Development in South Africa is guided by the principle of sustainability, and this is underpinned by integration, which is the consideration of social, economic and environmental factors in decision making. Policies are in place at national...

  6. A case study exploring the ethical and policy dimensions of allocating acute care resources to a dying patient.

    Science.gov (United States)

    Cooke, Mary; Hurley, Ciarán

    2008-05-01

    We aimed to identify policy, process and ethical issues related to allocation of National Health Service resources when patients with end-of-life illness are referred to acute care services. Sharing healthcare decisions denotes a different partnership between professionals and patients when patients are empowered to define their needs. Implementation of a transition from professional to patient decision-making appears to be dependent upon its interpretation by personnel delivering care using the local trust policy. The outcome of this is a reformation of responsibility for budget allocation, choice of acute care provider and selecting services, currently in the realm of primary care; be it the general practitioner, community practitioners, or the patient. We used a 'lens' approach to case study analysis in which the lens is constructed of a model of policy analysis and four principles of biomedical ethics. A patient's decision to decline care proposed by an Accident and Emergency department nurse and the nurse's response to that decision expose a policy that restricts the use of ambulance transport and with that, flexibility in responses to patients' decisions. End-of-life care partnership decisions require sensitivity and flexibility from all healthcare practitioners. We found that policy-based systems currently used to deliver care across the primary care - hospital care border are far from seamless and can lead to foreseeable problems. Health professionals responsible for the care of a patient at the end of life should consider the holistic outcomes of resource allocation decisions for patients. Government and health professional agenda suggest that patients should be given a greater element of control over their healthcare than has historically been the case. When patients take responsibility for their decisions, healthcare personnel should recognize that this signals a shift in the nature of the professional-patient relationship to one of partnership.

  7. Essays on globalization : policies in trade, development, resources and climate change

    OpenAIRE

    Kerkelä, Leena

    2009-01-01

    This dissertation on globalization consists of an introduction on the methodology applied, a summary and four independent essays focussing on applied policy research in international trade. The study follows the CGE (Computable General Equilibrium) research tradition. The simulation environment is the publicly available GTAP model. The essays examine the specific topics of trade and aid policies, price liberalization of the Russian energy markets, trade preferences in the sugar sector of the ...

  8. Sustainable natural resource use in rural China: Recent trends and policies

    NARCIS (Netherlands)

    Qu, F.; Kuyvenhoven, A.; Shi, X.; Heerink, N.

    2011-01-01

    In this paper we provide an overview of recent trends in the availability and quality of land and water resources in rural China, and examine the common presumption that rural resources are rapidly degrading in China. Data based on consistent definitions and measurement methods that have recently

  9. Meeting the Challenges of Higher Education in India through Open Educational Resources: Policies, Practices, and Implications

    Science.gov (United States)

    Thakran, Archana; Sharma, Ramesh C.

    2016-01-01

    Over the past two decades, the education sector in India has undergone a substantial transformation. Recent advances in technology have provided access to high quality educational resources and information on the Internet. This article examines the role of open educational resources (OER) in addressing the challenges of higher education in India,…

  10. The Analysis of Human Resources Policies and Regional Financial Accounting System on Regional Government Financial Statements’ Quality

    Directory of Open Access Journals (Sweden)

    Aida Nahar

    2018-02-01

    Full Text Available Accountability of local governments in the implementation of policies should be carried out with the financial statements present the quality. Qualitative characteristics of financial statements described in PP 24/ 2005 that the qualitative characteristics of financial statements is a normative measurement that needs to be realized in the accounting information that can be fulfil its purpose. To be able to raise the normative requirements, this characteristics is absolutely necessary in order to meet the government 's financial statements desired qualities are: relevant, reliable, comparable, and understandable.The population of this research is PPK-SKPD in Karesidenan Pati. Consisting of: Regency Jepara, Kudus, Pati , Rembang, Blora, and Grobogan, totally 113 SKPD with 73 respondents with a random sampling technique . Data analysis technique used is multiple regression analysis. The results mentioned that human resource policies affect the quality of financial reporting by 4.167. Implementation of the system accounting effect on the quality of financial reporting by 3.309 % . Human resources policies and implementation of accounting systems affect the quality of financial statements. This study did not succeed accept hypothesis 5 proved that the value of t = -1.021 and p = 0.311, which means that the BPK audit does not affect the relationship between the Application System Accounting for the Quality of Regional Financial Statements.

  11. A Policy study on cooperation for the development of underground resources in North Korea

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Jung Nam [Korea Energy Economics Institute, Euiwang (Korea)

    1999-03-01

    For the smooth promotion of joint development program of underground resources in North Korea, it requires a domestic legal authority applicable when a private company begins the development program of underground resources in North Korea. It is recommended that the supply of initial fund of resources development program in North Korea will utilize the supply method of existing resources development subsidizing fund instead of establishing new fund. In the case of enlarging its program by minerals, it is desirable to support it by creating the South-North resources development cooperation fund for a certain period to attract voluntary participation of the private sector. In this study, minerals able to develop among natural minerals in North Korea were classified and presented by grouping according to the higher order. Also, a plan for institutionalizing this was sought by connecting a development program by types of minerals for the smooth operation of South-North resources development cooperation program. Considering types of minerals, area, and the size and cost of development, it should be operated step by step, but for programs realizable at once, it should be started in its early stage. It is recommended to review a step by step plan for mineral resources development in North Korea continuously in connection with other economic cooperation sector such as the manufacturing industry. (author). 30 refs., 40 tabs.

  12. Adaptive Measurement-Based Policy-Driven QoS Management with Fuzzy-Rule-based Resource Allocation

    Directory of Open Access Journals (Sweden)

    Philip J. Morrow

    2012-07-01

    Full Text Available Fixed and wireless networks are increasingly converging towards common connectivity with IP-based core networks. Providing effective end-to-end resource and QoS management in such complex heterogeneous converged network scenarios requires unified, adaptive and scalable solutions to integrate and co-ordinate diverse QoS mechanisms of different access technologies with IP-based QoS. Policy-Based Network Management (PBNM is one approach that could be employed to address this challenge. Hence, a policy-based framework for end-to-end QoS management in converged networks, CNQF (Converged Networks QoS Management Framework has been proposed within our project. In this paper, the CNQF architecture, a Java implementation of its prototype and experimental validation of key elements are discussed. We then present a fuzzy-based CNQF resource management approach and study the performance of our implementation with real traffic flows on an experimental testbed. The results demonstrate the efficacy of our resource-adaptive approach for practical PBNM systems.

  13. U.S. Air Force Information Resources Management: An Exploratory Study of Policy

    National Research Council Canada - National Science Library

    Munoz, Brian

    1998-01-01

    .... Information Resources Management (IRM) was established within the Department of Defense (DoD) in 1983 as a tool for better managing its information in the wake of automated information processing and sharing...

  14. The role of the University in the context of Inclusive Education Policy: reflections about human resources formation and knowledge production

    Directory of Open Access Journals (Sweden)

    Rosana Glat

    2010-12-01

    Full Text Available The present text aims to discuss and present, briefly action lines about the role of University in the promotion of psicossocial and educational development of people with handicap and other special needs. Taking the framework of specialized literature, it brings different questions dealing with human resources formation, specially, teacher formation, and the production of knowledge in the area of Special Education, obtained through research and extension projects, done, preferentially, in partnership with the educational agents that work in the field. It also analyses how these actions may influence the implementation of policies regarding school, labor, and social inclusion of people with handicap and other developmental disorders.

  15. A Comparative Analysis of Aid Policies for Human Resource Development: United States and Japan.

    Science.gov (United States)

    Pickert, Sarah; Kuroda, Kazuo

    Official Development Assistance (ODA) is an increasingly important part of foreign aid budgets. Countries that offer foreign aid to other nations do so for many, often contradictory reasons that range from national security and economic self-interest to humanitarian concerns. Every donor state uses ODA as an instrument of its foreign policy. This…

  16. Implications of an Aging Labor Force for Human Resource Development Policy.

    Science.gov (United States)

    Barber, Gerard M.; And Others

    1992-01-01

    Demographic trends show that areas such as Kentucky, Japan, and Sweden are experiencing very limited labor force growth and heavier reliance on older workers as the younger population declines. Implications of an aging work force for policy involve pensions, health benefits, retraining, flexible work options, and income support programs. (SK)

  17. Inclusion of Students with Special Education Needs in French as a Second Language Programs: A Review of Canadian Policy and Resource Documents

    Science.gov (United States)

    Muhling, Stefanie; Mady, Callie

    2017-01-01

    This article describes a document analysis of policy and resource documents pertaining to inclusion of students with special education needs (SSEN) in Canadian French as a Second Language (FSL) programs. By recognizing gaps and acknowledging advancements, we aim to inform current implementation and future development of inclusive policy. Document…

  18. Resource-saving policy in the context of technological updating of ferroalloy production

    Directory of Open Access Journals (Sweden)

    Yelena Anatolyevna Pozdnyakova

    2011-06-01

    Full Text Available This paper substantiates the need for technological modernization of ferroalloy production which should be based on energy- and resource-saving technologies. Lean-technology is considered as a tool for effective management of material costs organization. A search algorithm for ways to improve the manufacturing process of a company, with which usage the author suggests a number of areas that require optimization, was developed. Measures aimed at solving the problems of resource-saving at JSC "Klyuchevsky Ferroalloy Plant" were proposed: introduction of resource saving technologies, suggesting involvement in the production of non-liquid products and the use of process waste and upgrading of individual processes. As a result of the proposed activities, tangible results have been achieved: reducing production costs, saving raw materials, reducing storage costs and release of additional areas, decrease of production losses.

  19. Environmental impacts assessment: Instruments for environmental policy making and resource management

    International Nuclear Information System (INIS)

    Cavelli, C.M.; Sartori, S.

    1993-06-01

    This review of evaluation criteria for environmental impacts assessments in Italy covers the following aspects: the efficacy of current Italian normatives governing assessment methods, the current approach of regional public administrations, the necessity for the creation of a national regulating board, environmental impacts assessment for complex environmental systems, the application of impacts assessment recommendations to resource development modelling in the planning of integrated environmental-economic systems, the involvement of the general public in decision making, techniques to determine the monetary worth of environmental resources, the use of multi-criteria analysis techniques

  20. A new public policy to ensure access to scientific information resources: the case of Chile

    Directory of Open Access Journals (Sweden)

    María Soledad Bravo-Marchant

    2012-11-01

    Full Text Available The design and implementation of public policies to grant access to scientific information is now a marked trend among numerous countries of Latin America. The creation of specific instruments, the allocation of an ongoing budget and the accumulation of experience in negotiation and contracting of national licences have all been clear signs of the achievements resulting from recent initiatives in these countries. This article reviews the experience of the Consorcio para el Acceso a la Información Cientifíca Electrónica (CINCEL Corporation, a Chilean consortium created in 2002, the public policy that made it possible and the evaluation experience of its main programme, the Electronic Library of Scientific Information (BEIC.

  1. Quality Improvement in Home-Based Child Care Settings: Research Resources to Inform Policy

    Science.gov (United States)

    Lawrence, Sharmila; Stephens, Samuel A.

    2016-01-01

    This "Topic of Interest" provides a comprehensive list of research in the Research Connections collection that was published in 2005 or later addressing issues related to quality improvement specifically in home-based child care. The resources are grouped under the following headings: Overviews, Summaries, and Reviews of Quality…

  2. World Bank Education Policy and Human Resource Development in Sub-Saharan Africa

    Science.gov (United States)

    Mutamba, Charlene

    2014-01-01

    There is increasing interest in the intersection of education and training through societal development in the developing world, a concept linked to national human resource development (NHRD). In addition, education and training is known to correlate strongly with employment outcomes that are connected to economic success, health and family…

  3. Students' Multilingual Resources and Policy-in-Action: An Australian Case Study

    Science.gov (United States)

    French, Mei

    2016-01-01

    In the context of increasing linguistic and cultural diversity in Australian schools, it is important to consider the value of students' multilingual resources for learning. This paper reports on an ethnographic case study conducted in an Australian metropolitan secondary school where the student body represented more than 40 cultures and…

  4. The framing of unconventional natural gas resources in the foreign energy policy discourse of the Russian Federation

    International Nuclear Information System (INIS)

    Ocelík, Petr; Osička, Jan

    2014-01-01

    The advent of unconventional resources of natural gas has altered the order on global as well as continental gas markets. With rising liquidity, the position of established dominant suppliers is eroding. We focus on the initial response of Russia, the leading supplier of natural gas to Europe, to the new situation, building the research on unit-level constructivism and discourse analysis. We use frame analysis to reveal what image of unconventional resources was constructed in Russian foreign energy policy discourse (FEPD) in the period between 2009 and 2011, when the “unconventional revolution” did not yet have any sharp contours. We conclude that in Russian FEPD the unconventionals are considered as a distinctive and inferior source of energy compared to conventional natural gas. Emphasis is put on their economic irrationality and environmental hazards. The bottom line of the discourse is the idea that there is a choice between conventional and unconventional sources, with this choice being framed as one between good and bad, or right and wrong. - Highlights: • We examine the image of “unconventional gas” in Russian foreign energy policy discourse. • Two main frames (reliable supplier and triumphant natural gas) were identified. • Two main argumentation schemes (economic and environmental) were identified. • The “unconventional gas” is defined as a mistaken and inferior source of energy

  5. The impact of the financial crisis on human resources for health policies in three southern-Europe countries.

    Science.gov (United States)

    Correia, Tiago; Dussault, Gilles; Pontes, Carla

    2015-12-01

    The public health sector has been the target of austerity measures since the global financial crisis started in 2008, while health workforce costs have been a source of rapid savings in most European Union countries. This article aims to explore how health workforce policies have evolved in three southern European countries under external constraints imposed by emergency financial programmes agreed with the International Monetary Fund, Central European Bank and European Commission. The selected countries, Greece, Portugal and Cyprus, show similarities with regard to corporatist systems of social protection and comprehensive welfare mechanisms only recently institutionalized. Based on document analysis of the Memoranda of Understanding agreed with the Troika, our results reveal broadly similar policy responses to the crisis but also important differences. In Cyprus, General Practitioners have a key position in reducing public expenditure through gatekeeping and control of users' access, while Portugal and Greece seeks to achieve cost containment by constraining the decision-making powers of professionals. All three countries lack innovation as well as monitoring and assessment of the effects of the financial crisis in relation to the health workforce. Consequently, there is a need for health policy development to use human resources more efficiently in healthcare. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  6. Policy Options for Addressing Health System and Human Resources for Health Crisis in Liberia Post-Ebola Epidemic

    Science.gov (United States)

    Budy, Fidel C.T.

    2015-01-01

    Qualified healthcare workers within an effective health system are critical in promoting and achieving greater health outcomes such as those espoused in the Millennium Development Goals. Liberia is currently struggling with the effects of a brutal 14-year long civil war that devastated health infrastructures and caused most qualified health workers to flee and settle in foreign countries. The current output of locally trained health workers is not adequate for the tasks at hand. The recent Ebola Virus Disease (EVD) exposed the failings of the Liberian healthcare system. There is limited evidence of policies that could be replicated in Liberia to encourage qualified diaspora Liberian health workers to return and contribute to managing the phenomenon. This paper reviews the historical context for the human resources for health crisis in Liberia; it critically examines two context-specific health policy options to address the crisis, and recommends reverse brain drain as a policy option to address the immediate and critical crisis facing the health care sector in Liberia. PMID:27622002

  7. Toward a sustainable utilization of land resources in China: problems, policies, and practices.

    Science.gov (United States)

    Hong, Wuyang; Li, Feixue; Li, Manchun; Zhang, Fangfang; Tong, Lihua; Huang, Qiuhao

    2014-10-01

    China's economy is growing explosively with double-digit rates of growth. However, behind the scenes of this economic miracle, a dark underbelly exists. The potential impact of the unsustainable use of land resources is increasing. Each parcel of land has a stationary geographic location, while its utilization is optional. The re-adjustment and optimization of land use patterns ought to be encouraged. Spatial reconstruction refers to the combination of various land elements, which can promote the rational and efficient allocation of land resources through a four-layer action framework: the development of unused land, urban renewal, ecological reconstruction, and spatial displacement. The feasibility and validity of these methods are illustrated by practical cases in different provinces in China. We thus propose that pursuing sustainable development and building an ecological civilization will be necessary for China in future decades.

  8. Exploring Resource Security Policy and Green Science and Technology in Asia

    Science.gov (United States)

    2014-04-01

    a “more pluralistic, non-European, non-Western world” where its dynamic economies have “retaken control of vast resources, huge assets, big markets...security and the dynamics of global politics cast within the Asian setting. Alongside the increasing urgency to extract and appropriate scarce...solar- powered microgrids that can provide clean light and charge phones to rural villagers. 18 Second, clean-energy is socialized as a critical

  9. Essays on globalization. Policies in trade, development, resources and climate change

    Energy Technology Data Exchange (ETDEWEB)

    Kerkelae, L.

    2009-07-01

    This research study on globalization consists of an introduction on the methodology applied, a summary and four independent essays focussing on applied policy research in international trade. The study follows the CGE (Computable General Equilibrium) research tradition. The simulation environment is the publicly available GTAP model. The essays examine the specific topics of trade and aid policies, price liberalization of the Russian energy markets, trade preferences in the sugar sector of the EU and the role of carbon sinks in mitigating climate change. The first essay examines trade and aid policies in Mozambique. The essay analyses the impact of alternative options like trade agreements, aid and trade facilitation. The results suggest that Mozambique has very little to gain from trade agreements or the Doha Round, although some agreements with the EU do yield some benefit. Trade facilitation and aid-for-trade programs on the other hand have the potential for larger benefits. The second essay examines the impact of liberalising RussiaAEs energy sector. The analysis is based on the implicit subsidies in regulated prices of electricity and gas and focuses on the effect of the different taxes and subsidies with respect to welfare and GDP in Russia and abroad. Increases in the price of electricity and gas improve efficiency and shift output from domestic markets to exports. The third essay investigates the impact of liberalising the EUAEs sugar sector by taking into account the complex structure of the EU sugar market and preferences in imports for developing countries. The fourth essay focuses on the effects of including carbon sinks into the analysis of the impacts of the Kyoto agreement. (orig.)

  10. Are government policies effective in promoting deployment of renewable electricity resources?

    International Nuclear Information System (INIS)

    Shrimali, Gireesh; Kniefel, Joshua

    2011-01-01

    Using a panel data over 50 US states and years 1991-2007, this paper uses a state fixed-effects model with state-specific time-trends to estimate the effects of state policies on the penetration of various emerging renewable electricity sources, including wind, biomass, geothermal, and solar photovoltaic. Renewable portfolio standards with either capacity or sales requirements have a significant impact on the penetration of all types of renewables-however, this impact is variable depending on the type of renewable source: it is negative for combined renewables, wind, and biomass; and positive for geothermal and solar. Further, clean energy funds and required green power options mostly result in increasing the penetration of all types of renewables. On the other hand, voluntary renewable portfolio standards as well as state green power purchasing programs are found to be ineffective in increasing the penetration of any type of renewable source. Finally, economic variables, such as electricity price, natural gas price, and per capita GDP as well as structural variables, such as league of conservation voters rating and the share of coal-generated electricity are found to be generally insignificant, suggesting the crucial role of policy in increasing the penetration of renewables. - Highlights: → Ascertains the impact of state policies on increasing the renewable capacity. → Renewable portfolio requirements have an (sometimes unexpected) impact. → Clean energy funds and required green power options have a positive impact. → Voluntary renewable standards as well as state green power purchasing requirements are ineffective. → Economics as well as political and structural variables are ineffective.

  11. Are resources a curse? Rentierism and energy policy in post-Soviet States

    Energy Technology Data Exchange (ETDEWEB)

    Gawrich, Andrea; Franke, Anja; Windwehr, Jana (eds.) [Kiel Univ. (Germany)

    2011-07-01

    The analysis of rentierism in post-Soviet states, which this book presents, underscores the need for further research as rentier state concepts have mainly been applied on ''older'' rentier states like Arab, African and Latin American countries. An important contribution to a topical discussion. During the last 30 years, many resource-rich countries have experienced economic and political stagnation (''resource curse''). They have developed deficient political systems in which the process of modern state formation is being undercut (''rentier state'') as well as economic structures in which sectors that provide strong incentives for the accumulation of physical and human capital are under-represented (''Dutch disease''). These political and economic challenges can be observed in many of the post-Soviet states with high resource incomes since the mid 1990s. Such incomes present opportunities for reducing poverty and promoting economic growth. But instead of taking advantage of these opportunities, many of them present authoritarian regimes with high levels of corruption, low political freedom and rent-seeking elites. The book gives an detailed analysis of rentierism in post-Soviet states. (orig.)

  12. Community nurse resource implications for a change in heparin prophylaxis policy

    Directory of Open Access Journals (Sweden)

    Parker Martyn J.

    2015-01-01

    Full Text Available Introduction: A review was undertaken for a consecutive series of hip fracture patients for the year before and then after a change in low dose heparin prophylaxis policy. Patients and methods: For the first year heparin was administered in hospital for a maximum of 14 days only. Patients sent home before this time were not discharged taking heparin. For the second year heparin was administered as recommended by NICE guidelines for 28 days from admission regardless of whether the patient was discharged. Results: For the first year 486 patients were treated with a mean of 10.4 doses of heparin per patient. For the second year 465 patients were treated with a mean of 24.3 doses per patient. In total an extra 6,464 doses of heparin were administered. 33.8% of patients were unable to administer their heparin at home therefore a district nurse administered 2,284 of these doses of subcutaneous heparin at the patient’s home. The increased cost associated with the change in policy was estimated to be £161 per patient, with over 90% of this increase being incurred by the district nurse expense. If applied nationally for the England, using extended heparin prophylaxis for hip fracture patients would cost in excess of 12 million pounds each year. Conclusion: Whilst the necessity for and duration of thromboembolic prophylaxis for these patients remains undetermined, there is a need to re-evaluate the cost effectiveness of the current recommendations for hip fracture patients.

  13. The water-energy-climate nexus: Resources and policy outlook for aquifers in Mexico

    Science.gov (United States)

    Scott, Christopher A.

    2011-06-01

    Three interlinked processes drive groundwater balances in diverse regions globally: (1) groundwater-irrigation intensification, (2) electrical energy supply for agriculture, and (3) climatic variability. Mexico's water-energy-climate nexus offers generic lessons because of its water scarcity and institutional reforms followed in other emerging economies. This paper analyzes data for 280 aquifers in Mexico, all registered water users, population projections, 2010-2100 precipitation and temperature projections for A1B and A2 emissions scenarios from 15 general circulation models, and 1999-2009 agricultural electricity use. Under A2 emissions, aquifers with negative balances will increase from 92 to 130 in number between 2010 and 2100, and the national groundwater deficit will increase by 21.3 km3. Under A2 and medium-variant population growth (which peaks midcentury), negative-balance aquifers will increase from 92 to 133, and the national groundwater deficit will increase by 22.4 km3. Agricultural power pricing offers a nexus-based policy tool to address aquifer depletion, an opportunity that was lost with the 2003 reduction in nighttime tariffs. Under A2, medium-variant population, and simulated 2% real annual increases in agricultural power tariffs, negative-balance aquifers will increase from 92 to 111, and the national groundwater deficit will increase by 17.5 km3 between 2010 and 2100. Regulatory and user-based groundwater management initiatives indicate growing awareness of aquifer depletion; however, the long-term outlook points to continued depletion. This raises the need to harness nexus-based policy options, i.e., increasing agricultural power tariffs, eliminating reduced nighttime tariffs, enforcing legislation linking groundwater extraction to power use, and limiting new power connections for groundwater wells.

  14. Translating science into policy: Using ecosystem thresholds to protect resources in Rocky Mountain National Park

    International Nuclear Information System (INIS)

    Porter, Ellen; Johnson, Susan

    2007-01-01

    Concern over impacts of atmospheric nitrogen deposition to ecosystems in Rocky Mountain National Park, Colorado, has prompted the National Park Service, the State of Colorado Department of Public Health and Environment, the Environmental Protection Agency, and interested stakeholders to collaborate in the Rocky Mountain National Park Initiative, a process to address these impacts. The development of a nitrogen critical load for park aquatic resources has provided the basis for a deposition goal to achieve resource protection, and parties to the Initiative are now discussing strategies to meet that goal by reducing air pollutant emissions that contribute to nitrogen deposition in the Park. Issues being considered include the types and locations of emissions to be reduced, the timeline for emission reductions, and the impact of emission reductions from programs already in place. These strategies may serve as templates for addressing ecosystem impacts from deposition in other national parks. - A collaborative approach between scientists and policymakers is described for addressing nitrogen deposition effects to Rocky Mountain National Park, USA

  15. A Policy Based Approach for the Management of Web Browser Resources to Prevent Anonymity Attacks in Tor

    Science.gov (United States)

    Navarro-Arribas, Guillermo; Garcia-Alfaro, Joaquin

    Web browsers are becoming the universal interface to reach applications and services related with these systems. Different browsing contexts may be required in order to reach them, e.g., use of VPN tunnels, corporate proxies, anonymisers, etc. By browsing context we mean how the user browsers the Web, including mainly the concrete configuration of its browser. When the context of the browser changes, its security requirements also change. In this work, we present the use of authorisation policies to automatise the process of controlling the resources of a Web browser when its context changes. The objective of our proposal is oriented towards easing the adaptation to the security requirements of the new context and enforce them in the browser without the need for user intervention. We present a concrete application of our work as a plug-in for the adaption of security requirements in Mozilla/Firefox browser when a context of anonymous navigation through the Tor network is enabled.

  16. From science to policy; A road map for a sustainable resource management in Turkey's marine EEZs

    Science.gov (United States)

    Gazihan, A.; Salihoglu, B.; Akoglu, E.; Oguz, T.

    2016-02-01

    This study provides a scientific base for Ecosystem Based Fisheries Management (EBFM) decisions for Turkey's exclusive economic zones in the Black Sea, the Marmara Sea, the Aegean Sea and the Mediterranean Sea. For this aim, an interdisciplinary holistic approach is employed to explore the linkages and feedbacks between changing national societal and economic needs, managerial decisions, environmental pressures and the health of regional marine ecosystems through derived socioeconomic and ecological indicators from statistical and field data as well as Ecopath with Ecosim (EwE) model results. Results quantified the level of human induced pressures driven by increasing societal and economic demands due to human population increase, national economic crises and corresponded governmental subsidies. Cumulative effects of these pressures together with changing climatic conditions deteriorated the marine resources and, as a consequence, limited the socio-economic services provided by ecosystems (e.g. nation-wide decreases in weight (-47%) and value (-37%) of landings, economic profitability (-61%) and per capita fish consumption (-29%) over the last decade). Even though the pressures increased correspondingly in all the marine regions, their consequences in the regional marine ecosystems realized differently. Observed trends in socioeconomic and ecologic indicators and past and future model scenario simulations done by Ecopath with Ecosim (EwE) model provided region-specific optimum EBFM options. Research results were synthesized specific to each responsible stakeholder groups and communicated by means of regional stakeholder meetings, project web-side, social and national media and scientific platforms. Present study is expected to increase the stakeholders' awareness for sustainable, responsible resource co-management and will be integrated into decision-making processes and serve as a model case study. This is a contribution funded by TUBITAK (113Y040 DEKOYON Project).

  17. Pricing Policies in Managing Water Resources in Agriculture: An Application of Contract Theory to Unmetered Water

    Directory of Open Access Journals (Sweden)

    Davide Viaggi

    2013-09-01

    Full Text Available The paper explores how agricultural water pricing could contribute to lowering water demand when uses are unobserved (asymmetric information. The topic of the paper is justified by the fact that most water authorities worldwide do not control water uses at the farm scale. The study draws inspiration from the pricing policies of a Reclamation and Irrigation Board in Northern Italy. It analyses the optimal design of current tariff strategies with respect both to the actual regulator’s goals and the cost recovery objective of an ideal regulator driven by European Water Framework Directive principles and having full information. The analysis is based on the logic of a Principal-Agent model implemented as a mathematical non-linear programming model. Given the current pricing structure and assuming zero transaction costs, the results show a relevant increase in net benefits for the ideal scenario with respect to the actual one as water use costs increase. Benefits differences between the two scenarios mark a limit in value below which mechanisms able to solve the existing asymmetries between the principal and the agents are economically desirable. The study concludes by showing that the current regulator’s discriminatory strategy (pricing structure would be better justified with higher levels of cost for water use. However, the existence of non-zero transaction costs related to the control of water uses points to the need for further research in order to analyze incentive mechanisms in the absence of water metering.

  18. Factors associated with job satisfaction among commune health workers: implications for human resource policies

    Directory of Open Access Journals (Sweden)

    Bach Xuan Tran

    2013-01-01

    Full Text Available Background: Job satisfaction among health workers is an important indicator in assessing the performance and efficiency of health services. Objective: This study measured job satisfaction and determined associated factors among health workers in 38 commune health stations in an urban district and a rural district of Hanoi, Vietnam. A total of 252 health workers (36 medical doctors and 216 nurses and technicians; 74% female were interviewed. A job satisfaction measure was developed using factor analysis, from which four dimensions emerged, namely ‘benefits and prospects,’ ‘facility and equipment,’ ‘performance,’ and ‘professionals.’ Results: The results demonstrate that respondents were least satisfied with the following categories: salary and incentives (24.0%, benefit packages (25.1%, equipment (35.7%, and environment (41.8%. The average satisfaction score was moderate across four domains; it was the highest for ‘performance’ (66.6/100 and lowest for ‘facility and equipment’ (50.4/100. Tobit-censored regression models, constructed using stepwise selection, determined significant predictors of job satisfaction including age, areas of work and expertise, professional education, urban versus rural setting, and sufficient number of staff. Conclusion: The findings highlight the need to implement health policies that focus on incentives, working conditions, workloads, and personnel management at grassroots level.

  19. Factors associated with job satisfaction among commune health workers: implications for human resource policies.

    Science.gov (United States)

    Tran, Bach Xuan; Van Hoang, Minh; Nguyen, Hinh Duc

    2013-01-30

    Job satisfaction among health workers is an important indicator in assessing the performance and efficiency of health services. This study measured job satisfaction and determined associated factors among health workers in 38 commune health stations in an urban district and a rural district of Hanoi, Vietnam. A total of 252 health workers (36 medical doctors and 216 nurses and technicians; 74% female) were interviewed. A job satisfaction measure was developed using factor analysis, from which four dimensions emerged, namely 'benefits and prospects,' 'facility and equipment,' 'performance,' and 'professionals.' The results demonstrate that respondents were least satisfied with the following categories: salary and incentives (24.0%), benefit packages (25.1%), equipment (35.7%), and environment (41.8%). The average satisfaction score was moderate across four domains; it was the highest for 'performance' (66.6/100) and lowest for 'facility and equipment' (50.4/100). Tobit-censored regression models, constructed using stepwise selection, determined significant predictors of job satisfaction including age, areas of work and expertise, professional education, urban versus rural setting, and sufficient number of staff. The findings highlight the need to implement health policies that focus on incentives, working conditions, workloads, and personnel management at grassroots level.

  20. Vancouver Board of Trade Policy Forum 2002 : B.C.'s oil and gas industry : tapping this abundant resource

    International Nuclear Information System (INIS)

    2002-01-01

    This policy forum focused on the economic importance of the oil and gas industry in British Columbia. The industry provides more than $2 billion and more than 40,000 jobs to the economic activity of the province. Strong demand for natural gas and oil, along with increased prices, offer a very optimistic long-term outlook for the oil and gas sector in British Columbia. Key representatives of the industry presented their views of current and potential oil and gas production, transmission and distribution in the province. In particular, offshore and mainland resource development were addressed with some reference to an alternative energy source, coalbed methane, a natural gas found in most coal deposits. It is estimated that the resource potential for coalbed methane is 90 to 250 trillion cubic feet, worth hundreds of billion dollars. The issue of pipelines was also addressed. One key representative criticized the 30-year old moratorium on gas exploration drilling in BC, claiming that expansion of offshore operations would provide significant advantages regarding taxes and employment opportunities within the province

  1. The Social Process of Analyzing Real Water Resource Systems Plans and Management Policies

    Science.gov (United States)

    Loucks, Daniel

    2016-04-01

    Developing and applying systems analysis methods for improving the development and management of real world water resource systems, I have learned, is primarily a social process. This talk is a call for more recognition of this reality in the modeling approaches we propose in the papers and books we publish. The mathematical models designed to inform planners and managers of water systems that we see in many of our journals often seem more complex than they need be. They also often seem not as connected to reality as they could be. While it may be easier to publish descriptions of complex models than simpler ones, and while adding complexity to models might make them better able to mimic or resemble the actual complexity of the real physical and/or social systems or processes being analyzed, the usefulness of such models often can be an illusion. Sometimes the important features of reality that are of concern or interest to those who make decisions can be adequately captured using relatively simple models. Finding the right balance for the particular issues being addressed or the particular decisions that need to be made is an art. When applied to real world problems or issues in specific basins or regions, systems modeling projects often involve more attention to the social aspects than the mathematical ones. Mathematical models addressing connected interacting interdependent components of complex water systems are in fact some of the most useful methods we have to study and better understand the systems we manage around us. They can help us identify and evaluate possible alternative solutions to problems facing humanity today. The study of real world systems of interacting components using mathematical models is commonly called applied systems analyses. Performing such analyses with decision makers rather than of decision makers is critical if the needed trust between project personnel and their clients is to be developed. Using examples from recent and ongoing

  2. Removing financial barriers to access reproductive, maternal and newborn health services: the challenges and policy implications for human resources for health.

    Science.gov (United States)

    McPake, Barbara; Witter, Sophie; Ensor, Tim; Fustukian, Suzanne; Newlands, David; Martineau, Tim; Chirwa, Yotamu

    2013-09-22

    The last decade has seen widespread retreat from user fees with the intention to reduce financial constraints to users in accessing health care and in particular improving access to reproductive, maternal and newborn health services. This has had important benefits in reducing financial barriers to access in a number of settings. If the policies work as intended, service utilization rates increase. However this increases workloads for health staff and at the same time, the loss of user fee revenues can imply that health workers lose bonuses or allowances, or that it becomes more difficult to ensure uninterrupted supplies of health care inputs.This research aimed to assess how policies reducing demand-side barriers to access to health care have affected service delivery with a particular focus on human resources for health. We undertook case studies in five countries (Ghana, Nepal, Sierra Leone, Zambia and Zimbabwe). In each we reviewed financing and HRH policies, considered the impact financing policy change had made on health service utilization rates, analysed the distribution of health staff and their actual and potential workloads, and compared remuneration terms in the public sectors. We question a number of common assumptions about the financing and human resource inter-relationships. The impact of fee removal on utilization levels is mostly not sustained or supported by all the evidence. Shortages of human resources for health at the national level are not universal; maldistribution within countries is the greater problem. Low salaries are not universal; most of the countries pay health workers well by national benchmarks. The interconnectedness between user fee policy and HRH situations proves difficult to assess. Many policies have been changing over the relevant period, some clearly and others possibly in response to problems identified associated with financing policy change. Other relevant variables have also changed.However, as is now well

  3. An alternative policy evaluation of the British Columbia carbon tax: broadening the application of Elinor Ostrom's design principles for managing common-pool resources

    Directory of Open Access Journals (Sweden)

    Karine Lacroix

    2015-06-01

    Full Text Available Climate change is putting infrastructure, food supply, water resources, ecosystems, and human health at risk. These risks will be exacerbated depending on the degree of additional greenhouse gas emissions. Urgent action is needed to limit the severity of impacts associated with further warming. British Columbia (BC has taken action to reduce greenhouse gas emissions from carbon-based fuels by introducing a carbon tax in 2008. As an innovative approach to climate change mitigation, especially in North America, studies evaluating its effectiveness are valuable. We assessed the long-term viability potential of the BC carbon tax using common pool resource design principles, a novel application of the design principles to environmental policy. We found that the design principles can be applied productively to environmental policy and larger scale air pollution problems. With regard to the BC carbon tax, our findings suggest that closer monitoring of user behavior, further increases of the tax over time, and pursuing efforts for a more elaborate system of nested enterprises and interjurisdictional cooperation could increase the long-term success of the BC carbon tax. We also found that the design principles allowed us to more comprehensively reach conclusions regarding the broader effectiveness of the tax when compared to existing policy analysis. Traditionally, climate policy evaluation has focused on the end goal without considering broader constraints and issues of resource allocation. We suggest that common pool resource theory, which is based on strong theoretical principles and encourages reflexivity, will be able to address those limitations.

  4. A scoping review of training and deployment policies for human resources for health for maternal, newborn, and child health in rural Africa.

    Science.gov (United States)

    Murphy, Gail Tomblin; Goma, Fastone; MacKenzie, Adrian; Bradish, Stephanie; Price, Sheri; Nzala, Selestine; Rose, Annette Elliott; Rigby, Janet; Muzongwe, Chilweza; Chizuni, Nellisiwe; Carey, Amanda; Hamavhwa, Derrick

    2014-12-16

    Most African countries are facing a human resources for health (HRH) crisis, lacking the required workforce to deliver basic health care, including care for mothers and children. This is especially acute in rural areas and has limited countries' abilities to meet maternal, newborn, and child health (MNCH) targets outlined by Millennium Development Goals 4 and 5. To address the HRH challenges, evidence-based deployment and training policies are required. However, the resources available to country-level policy makers to create such policies are limited. To inform future HRH planning, a scoping review was conducted to identify the type, extent, and quality of evidence that exists on HRH policies for rural MNCH in Africa. Fourteen electronic health and health education databases were searched for peer-reviewed papers specific to training and deployment policies for doctors, nurses, and midwives for rural MNCH in African countries with English, Portuguese, or French as official languages. Non-peer reviewed literature and policy documents were also identified through systematic searches of selected international organizations and government websites. Documents were included based on pre-determined criteria. There was an overall paucity of information on training and deployment policies for HRH for MNCH in rural Africa; 37 articles met the inclusion criteria. Of these, the majority of primary research studies employed a variety of qualitative and quantitative methods. Doctors, nurses, and midwives were equally represented in the selected policy literature. Policies focusing exclusively on training or deployment were limited; most documents focused on both training and deployment or were broader with embedded implications for the management of HRH or MNCH. Relevant government websites varied in functionality and in the availability of policy documents. The lack of available documentation and an apparent bias towards HRH research in developed areas suggest a need for

  5. Finding a VOICE for UK clinical pharmacology.

    Science.gov (United States)

    Aronson, Jeffrey K

    2012-06-01

    At a James Black Conference held in Oxford on 20-22 June 2011, a group of senior clinical pharmacologists and their junior colleagues, other medical specialists, and pharmacists discussed an agenda for UK clinical pharmacology for the next 5 years, addressing the following broad questions. How should UK clinical pharmacology be further developed and delivered as a discipline in universities, the NHS, pharmaceutical companies, and regulatory authorities? How should teaching and training in UK clinical pharmacology and therapeutics be delivered and assessed? What topics should be priorities for research in UK academic clinical pharmacology? How should clinical pharmacology contribute to UK drugs policy? How should pharmacology and clinical pharmacology be further integrated, to the benefit of both? Numerous recommendations emerged, under the collective acronym VOICE, standing for Visibility, Outreach, Integration, Coverage and Emissaries. VISIBILITY: The visibility of the discipline needs to be increased. This could be done, for example, by increased activities in acute general medicine/toxicology, through activities of Medicines and Therapeutics Committees, participation in grand rounds, teaching and training, and monitoring therapeutic interventions, and by offering bolt-on training for other specialists (for example, short courses, MSc courses, and training programmes). OUTREACH: Methods of increasing outreach include roadshows in schools/medical schools, national special study modules, public education, press coverage, and social marketing. INTEGRATION: Closer collaborations with pharmacologists, clinical pharmacists, other prescribers, and pharmaceutical companies (e.g. through joint training programmes) are desirable. COVERAGE: Attention to neglected areas, such as general practice, paediatrics, obstetrics, geriatrics, anaesthetics, cancer, and immunology. EMISSARIES: Trainees to spread the word. © 2012 The Author. British Journal of Clinical Pharmacology

  6. An Analysis of Current Energy Policy Initiatives in New Mexico. What are the Potential Impacts to the State's Water Resources?

    Science.gov (United States)

    Klise, G. T.; Hart, W. E.; Kobos, P. H.; Malczynski, L. A.; Tidwell, V. C.

    2008-12-01

    Population in New Mexico is increasing rapidly with recent projections showing that the state will add more than 1 million people by 2035. This growth will create a demand for additional energy and water supplies that have yet to be developed. New Mexico currently exports about 50% of the energy generated within the state to neighboring states, and existing power plants predominately utilize traditional fossil fuels such as coal, oil and natural gas. Because traditional electric generation technologies utilize large quantities of water, New Mexico can also be seen as exporting water for the benefit of electricity consumed in neighboring states. As it is, both surface water and groundwater supplies are stretched thin and these internal and external stresses stemming from population growth will have a substantial impact on the state's water resources. In 2004, the Governor laid out a plan to make New Mexico a "Clean Energy State" by implementing renewable portfolio standards, developing renewable energy transmission infrastructure, creating an alternative energy innovation fund and creating state specific tax credits for renewable energy production and manufacturing. Recent work in the National Energy-Water Roadmap has pointed out that certain renewable sources of energy utilize less water than traditional power plants, and technological fixes to existing power plants will result in less water consumption. If New Mexico carries out its energy initiative, what will be the impacts to the state's water resources? Will it be possible to meet competing demands for this water? These questions and others will be analyzed in a decision-support tool that can look at the connection between both the physical and economic systems to see what the tradeoffs might be as a result of specific policy decisions. The ability to plan for future energy needs and understanding potential impacts to the state's limited water resources will be an invaluable tool for decision-makers in New

  7. Finding Common Ground: A Critical Review of Land Use and Resource Management Policies in Ontario, Canada and their Intersection with First Nations

    Directory of Open Access Journals (Sweden)

    Fraser McLeod

    2015-01-01

    Full Text Available This article provides an in-depth analysis of selective land use and resource management policies in the Province of Ontario, Canada. It examines their relative capacity to recognize the rights of First Nations and Aboriginal peoples and their treaty rights, as well as their embodiment of past Crown–First Nations relationships. An analytical framework was developed to evaluate the manifest and latent content of 337 provincial texts, including 32 provincial acts, 269 regulatory documents, 16 policy statements, and 5 provincial plans. This comprehensive document analysis classified and assessed how current provincial policies address First Nation issues and identified common trends and areas of improvement. The authors conclude that there is an immediate need for guidance on how provincial authorities can improve policy to make relationship-building a priority to enhance and sustain relationships between First Nations and other jurisdictions.

  8. Advancing pharmacometrics and systems pharmacology.

    Science.gov (United States)

    Waldman, S A; Terzic, A

    2012-11-01

    Pharmacometrics and systems pharmacology are emerging as principal quantitative sciences within drug development and experimental therapeutics. In recognition of the importance of pharmacometrics and systems pharmacology to the discipline of clinical pharmacology, the American Society for Clinical Pharmacology and Therapeutics (ASCPT), in collaboration with Nature Publishing Group and Clinical Pharmacology & Therapeutics, has established CPT: Pharmacometrics & Systems Pharmacology to inform the field and shape the discipline.

  9. Medicinal, Pharmacological and Phytochemical Potentials of ...

    African Journals Online (AJOL)

    Medicinal, Pharmacological and Phytochemical Potentials of Annona Comosus linn. Peel - A Review. ... In Africa, many natural resources are used for obtaining pharmaceuticals that have a high national and international economic value. Various parts of Annonacomosus have been used as anti-inflammatory, proteolytic ...

  10. SD simulation study on degraded farmland policy on farming-pastoral area under the constrains of water resources-Taking Tongliao City of Inner Mongolia as example

    Science.gov (United States)

    Xu, D. P.; Zhao, B.; Li, T. S.; Zhu, J. W.; Yu, M. M.

    2017-08-01

    Water resources are the primary factor in restricting the sustainable development of farming-pastoral regions. To support the sustainable development of water resources, whether or not the land uses patterns of farming-pastoral areas is a reasonably important issue. This paper takes Tongliao city as example for the purpose of sustainably developing the farming-pastoral area in the north. Several scientific preductions and evaluations were conducted to study the farming-pastoral landuse pattern, which is the key problem that effects sustainable development of farming-pastoral areas. The paper then proposes that 1:7 landuse pattern is suitable for the sustainable development of farming-pastotal area. Based on the analysis of the research findings on sustainable development of farming-pastoral area, the paper established a suitability evaluation indicators system of degraded farmland policies in Tongliao city, and used an Analytical Hierarchy Process (AHP) method to determine the weight to run system dynamic (SD) model. The simulation results were then obtained on social economic ecological development in Tongliao city under different degraded farmland policies, and used the comprehensive evaluation model to optimize the results. It is concluded that stabilizing the policy of degraded farmland policy is the preferential policy in Tongliao, which provides useful theoretical research for the sustainable development of farming-pastoral area.

  11. Biological and Pharmacological properties

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Biological and Pharmacological properties. NOEA inhibits Ceramidase. Anandamide inhibits gap junction conductance and reduces sperm fertilizing capacity. Endogenous ligands for Cannabinoid receptors (anandamide and NPEA). Antibacterial and antiviral ...

  12. Meeting human resources for health staffing goals by 2018: a quantitative analysis of policy options in Zambia

    Directory of Open Access Journals (Sweden)

    Schroder Kate

    2010-06-01

    Full Text Available Abstract Background The Ministry of Health (MOH in Zambia is currently operating with fewer than half of the health workers required to deliver basic health services. The MOH has developed a human resources for health (HRH strategic plan to address the crisis through improved training, hiring, and retention. However, the projected success of each strategy or combination of strategies is unclear. Methods We developed a model to forecast the size of the public sector health workforce in Zambia over the next ten years to identify a combination of interventions that would expand the workforce to meet staffing targets. The key forecasting variables are training enrolment, graduation rates, public sector entry rates for graduates, and attrition of workforce staff. We model, using Excel (Office, Microsoft; 2007, the effects of changes in these variables on the projected number of doctors, clinical officers, nurses and midwives in the public sector workforce in 2018. Results With no changes to current training, hiring, and attrition conditions, the total number of doctors, clinical officers, nurses, and midwives will increase from 44% to 59% of the minimum necessary staff by 2018. No combination of changes in staff retention, graduation rates, and public sector entry rates of graduates by 2010, without including training expansion, is sufficient to meet staffing targets by 2018 for any cadre except midwives. Training enrolment needs to increase by a factor of between three and thirteen for doctors, three and four for clinical officers, two and three for nurses, and one and two for midwives by 2010 to reach staffing targets by 2018. Necessary enrolment increases can be held to a minimum if the rates of retention, graduation, and public sector entry increase to 100% by 2010, but will need to increase if these rates remain at 2008 levels. Conclusions Meeting the minimum need for health workers in Zambia this decade will require an increase in health

  13. [Pharmacological treatment of dyslexia].

    Science.gov (United States)

    Artigas-Pallarés, J

    Pharmacological approaches aimed at improving dyslexia are almost inexistent. To analyse, based on the current theories of dyslexia, the possibility of applying some pharmacological measure. The different theories on dyslexia are discussed. The multiple deficit model is then outlined, in opposition to the classical single dysfunction model. The model described provides a coherent explanation for several conceptual dilemmas that arise from the analysis of the comorbidity of dyslexia. The few pharmacological interventions that have been proposed to date are also analysed; with the exception of stimulants, however, they are not supported by any solid theoretical base about dyslexia. Lastly, we use the multiple deficit model as an aid to analyse the current data referring to the effect of stimulants on nuclear mechanisms in dyslexia. It is suggested that it would be wise to monitor the response in reading skills in children with dyslexia and attention deficit hyperactivity disorder (ADHD) who are being treated with stimulants. We also recommend taking into consideration the comorbidity between dyslexia and ADHD as an argument in favour of pharmacological intervention in patients with apparently mild symptoms of ADHD. In any case, today, pharmacological intervention cannot be expected to go beyond its having a complementary and synergic effect on traditional methods of treatment.

  14. Developmental paediatric anaesthetic pharmacology

    DEFF Research Database (Denmark)

    Hansen, Tom Giedsing

    2015-01-01

    Safe and effective drug therapy in neonates, infants and children require detailed knowledge about the ontogeny of drug disposition and action as well how these interact with genetics and co-morbidity of children. Recent advances in developmental pharmacology in children follow the increased...

  15. PHARMACOLOGICAL PROPERTIES OF SECURIDACA ...

    African Journals Online (AJOL)

    Methanolic Extract of the root-bark of Securidaca longipedunculata was tested for pharmacological activity on isolated vascular and extra-vascular smooth muscle preparations. The root barks extract (50-800mg/ml) inhibited and/or abolished, in a concentration-dependent manner, the myogenic, spontaneous contractions ...

  16. CLINICAL PHARMACOLOGY OF DIURETICS

    Directory of Open Access Journals (Sweden)

    I. V. Soldatenko

    2014-06-01

    Full Text Available Clinical pharmacology of diuretics in the international system of ATC (anatomic-therapeutic-chemical is presented. Classification of this group by the action mechanism and caused effects is provided. Pharmacokinetics and pharmacodynamics features, indications and principles of diuretics usage in clinics are considered. Contraindications, side effects and interaction with other drugs of this group are discussed in detail.

  17. Pharmacological management of obesity.

    Science.gov (United States)

    Velazquez, Amanda; Apovian, Caroline M

    2017-04-28

    Current management of obesity includes three main arms: behavioral modification, pharmacologic therapy, and bariatric surgery. Decades prior, the only pharmacological agents available to treat obesity were approved only for short-term use (≤ 12 weeks) by the Food and Drug Administration (FDA). However, in the last several years, the FDA has approved several medications for longer term treatment of obesity. This highlights the important progression that we, as a society, better appreciate now the chronicity and complexity of obesity as a disease. Also, availability of more medication options gives healthcare providers more possibilities to consider in the management of obesity. Medications for obesity can be simply categorized as FDA approved short-term use (diethylproprion, phendimetrazine, benzphetamine, and phentermine) and long-term use (orlistat, phentermine/topiramate ER, lorcaserin, naltrexone/bupropion ER and liraglutide). Additionally, type 2 diabetes (T2DM) is commonly seen in patients with obesity and necessitates consideration of pharmacological options that do not hinder patients' weight loss. Finally, weight-centric prescribing is also an important component to pharmacological management of obesity. It warrants that healthcare providers thoroughly review their patients' medication lists to determine if any of these agents could be contributing to weight gain.

  18. Exploration of an Optimal Policy for Water Resources Management Including the Introduction of Advanced Sewage Treatment Technologies in Zaozhuang City, China

    Directory of Open Access Journals (Sweden)

    Gengyu He

    2016-12-01

    Full Text Available Water shortage and water pollution are important factors restricting sustainable social and economic development. As a typical coal resource-exhausted city and a node city of the South-to-North Water Transfer East Route Project in China, Zaozhuang City’s water resources management faces multiple constraints such as transformation of economic development, restriction of groundwater exploitation, and improvement of water environment. In this paper, we develop a linear optimization model by input–output analysis to study water resources management with the introduction of three advanced sewage treatment technologies for pollutant treatment and reclaimed water production. The simulation results showed that from 2014 to 2020, Zaozhuang City will realize an annual GDP growth rate of 7.1% with an annual chemical oxygen demand (COD emissions reduction rate of 5.5%. The proportion of primary industry, secondary industry, and tertiary industry would be adjusted to 5.6%, 40.8%, and 53.6%, respectively. The amount of reclaimed water supply could be increased by 91% and groundwater supply could be decreased by 6%. Based on the simulation, this model proposes a scientific reference on water resources management policies, including water environment control, water supply plan, and financial subsidy, to realize the sustainable development of economy and water resources usage.

  19. Co-Optimization of Electricity Transmission and Generation Resources for Planning and Policy Analysis: Review of Concepts and Modeling Approaches

    Energy Technology Data Exchange (ETDEWEB)

    Krishnan, Venkat; Ho, Jonathan; Hobbs, Benjamin F.; Liu, Andrew L.; McCalley, James D.; Shahidehpour, Mohammad; Zheng, Qipeng P.

    2016-05-01

    The recognition of transmission's interaction with other resources has motivated the development of co-optimization methods to optimize transmission investment while simultaneously considering tradeoffs with investments in electricity supply, demand, and storage resources. For a given set of constraints, co-optimized planning models provide solutions that have lower costs than solutions obtained from decoupled optimization (transmission-only, generation-only, or iterations between them). This paper describes co-optimization and provides an overview of approaches to co-optimizing transmission options, supply-side resources, demand-side resources, and natural gas pipelines. In particular, the paper provides an up-to-date assessment of the present and potential capabilities of existing co-optimization tools, and it discusses needs and challenges for developing advanced co-optimization models.

  20. Further Democratizing Latin America: Broadening Access to Higher Education and Promoting Science Policies Focused on the Advanced Training of Human Resources

    Directory of Open Access Journals (Sweden)

    Manuel Heitor

    2014-08-01

    Full Text Available We focus this paper on the conditions to build reliable science, technology and higher education systems in Latin America, based on international comparative studies, fieldwork and interviews conducted over the last three years. The analysis shows that science can have a major role in furthering the democratization of society through public policies that foster opportunities to access knowledge and the advanced training of human resources. Broadening the social basis for higher education promotes the qualification of the labour force and contributes to social and economic development. The need to guarantee higher education diversity, strengthening scientific institutions and investing in a strong science base, is deemed as critical, but goes far beyond policies centred on innovation and industry-science relationships. It requires adequate training and attraction of skilled people, as well as the social promotion of a scientific and technological culture.

  1. IMPROVING DEPOSIT POLICY BANK ON THE BASIS OF ANALYSIS OF THE INFLUENCE OF DEPOSIT PORTFOLIO STRUCTURE ON FORMATION OF INVESTMENT RESOURCE

    Directory of Open Access Journals (Sweden)

    Viadrova I.

    2018-01-01

    Full Text Available Introduction. The banking system as a part of the national economy contributes to the development of various branches of economy and trade, enabling the realization of economic interests of economic entities. One of the important tasks of the monetary system is the accumulation of financial resources necessary for the implementation of credit and investment projects and their further distribution. This task is performed by banking institutions by attracting funds from individuals and legal entities. The size of the bank’s resource base and the scale of its operations depend on the operations of attraction of funds. The priority task of the banking institution is the predominance of attracting long-term investments over short-term ones. That is why the problem that exists in the disproportion of the maturity of borrowed funds, the prevalence of short-term deposits over long-term and the minimum amount of long-term resources in the bank’s deposit portfolio is particularly relevant. Purpose. The purpose of the work is to generalize the theoretical aspects of bank deposit activity and to determine the optimal structure of the deposit portfolio for carrying out of credit and investment activity. Results. The article summarizes the essence of the concept of “deposit policy”, identifies the peculiarities of its formation and analyzes the main external and internal factors that have an impact on the deposit policy of domestic banks. The analysis of the dynamics and structure of deposit operations of banks at the state level was carried out and the analysis of deposit policy of a bank of foreign bank groups – PJSC “Ukrsotsbank” for 2010-2017 was provided. In this work, the factors of influence are investigated: external and internal, which determine the ways of formation of deposit policy by banks of Ukraine. The influence of the structure of the deposit portfolio of Ukrainian banks on the formation of the investment resource is analyzed

  2. INCORPORATING RESILIENCE INTO LAW AND POLICY: A case for preserving a natural resource legacy and promoting a sustainable future

    Science.gov (United States)

    The concept of sustainability has been widely embraced by society and in environmental law and policy as a measure to ensure a heritage of economic viability, social equity, and environmental stewardship. In a large number of statutes, Congress and many state legislatures have be...

  3. The Mexico-United States Border: Public Policy and Chicano Economic Welfare. Studies in Human Resources Development No. 2.

    Science.gov (United States)

    Briggs, Vernon M., Jr.

    In 1970, the gross national product for the United States was over $974 billion; for Mexico, it was $33 billion. The U.S. per capita national income was approximately $4,300, while Mexico's was slightly above $500. Living as neighbors with the reality of these vast differences has led to the implementation of various policy measures by both…

  4. Laboratories of Reform? Human Resource Management Strategies in Illinois Charter Schools. Policy Research: IERC 2016-1

    Science.gov (United States)

    White, Bradford R.

    2016-01-01

    Charter schools are publicly-funded educational entities that operate independently from local school districts and are exempt from certain state and local requirements, particularly with regard to teacher personnel policy. In exchange for this flexibility, charter schools are held more accountable for results and may be shut down if they fail to…

  5. Pharmacological treatment of obesity.

    Science.gov (United States)

    Mancini, Marcio C; Halpern, Alfredo

    2006-04-01

    This review offers an overview of physiological agents, current therapeutics, as well as medications, which have been extensively used and those agents not currently available or non-classically considered anti-obesity drugs. As obesity - particularly that of central distribution - represents an important triggering factor for insulin resistance, its pharmacological treatment is relevant in the context of metabolic syndrome control. The authors present an extensive review on the criteria for anti-obesity management efficacy, on physiological mechanisms that regulate central and/or peripheral energy homeostasis (nutrients, monoamines, and peptides), on beta-phenethylamine pharmacological derivative agents (fenfluramine, dexfenfluramine, phentermine and sibutramine), tricyclic derivatives (mazindol), phenylpropanolamine derivatives (ephedrin, phenylpropanolamine), phenylpropanolamine oxytrifluorphenyl derivative (fluoxetine), a naftilamine derivative (sertraline) and a lipstatine derivative (orlistat). An analysis of all clinical trials - over ten-week long - is also presented for medications used in the management of obesity, as well as data about future medications, such as a the inverse cannabinoid agonist, rimonabant.

  6. Pharmacological treatment of obesity

    OpenAIRE

    Mancini, Marcio C.; Halpern, Alfredo

    2006-01-01

    This review offers an overview of physiological agents, current therapeutics, as well as medications, which have been extensively used and those agents not currently available or non-classically considered anti-obesity drugs. As obesity - particularly that of central distribution - represents an important triggering factor for insulin resistance, its pharmacological treatment is relevant in the context of metabolic syndrome control. The authors present an extensive review on the criteria for ...

  7. Social Pharmacology: Expanding horizons

    Science.gov (United States)

    Maiti, Rituparna; Alloza, José Luis

    2014-01-01

    In the current modern and global society, social changes are in constant evolution due to scientific progress (technology, culture, customs, and hygiene) and produce the freedom in individuals to take decisions by themselves or with their doctors toward drug consumption. In the arena of marketed drug products which includes society, individual, administration, and pharmaceutical industry, the young discipline emerged is social pharmacology or sociopharmacology. This science arises from clinical pharmacology, and deals with different parameters, which are important in creating knowledge on marketed drugs. However, the scope of “social pharmacology” is not covered by the so-called “Phase IV” alone, but it is the science that handles the postmarketing knowledge of drugs. The social pharmacology studies the “life cycle” of any marketed pharmaceutical product in the social terrain, and evaluates the effects of the real environment under circumstances totally different in the drug development process. Therefore, there are far-reaching horizons, plural, and shared predictions among health professionals and other, for beneficial use of a drug, toward maximizing the benefits of therapy, while minimizing negative social consequences. PMID:24987168

  8. Pharmacological interactions of vasoconstrictors.

    Science.gov (United States)

    Gómez-Moreno, Gerardo; Guardia, Javier; Cutando, Antonio; Calvo-Guirado, José Luis

    2009-01-01

    This article is the first of a series on pharmacological interactions involving medicaments commonly prescribed and/or used in odontology: vasoconstrictors in local anaesthetics and anti-inflammatory and anti-microbial analgesics. The necessity for the odontologist to be aware of adverse reactions as a result of the pharmacological interactions is due to the increase in medicament consumption by the general population. There is a demographic change with greater life expectancy and patients have increased chronic health problems and therefore have increased medicament intake. The presence of adrenaline (epinephrine) and other vasoconstrictors in local odontological anaesthetics is beneficial in relation to the duration and depth of anaesthesia and reduces bleeding and systemic toxicity of the local anaesthetic. However, it might produce pharmacological interactions between the injected vasoconstrictors and the local anaesthetic and adrenergic medicament administered exogenically which the odontologist should be aware of, especially because of the risk of consequent adverse reactions. Therefore the importance of conducting a detailed clinical history of the general state of health and include all medicaments, legal as well as illegal, taken by the patient.

  9. Pharmacology of Reye syndrome.

    Science.gov (United States)

    Pranzatelli, M R; De Vivo, D C

    1987-04-01

    Reye syndrome, a reversible metabolic encephalopathy and hepatopathy, offers a unique opportunity to investigate the pharmacologic mechanisms by which a toxic-metabolic insult to mitochondria is translated into neurochemical and neurologic dysfunction. Similarity of some clinical and metabolic abnormalities between certain inborn errors of organic acid, ammonia, and carbohydrate metabolism and Reye syndrome suggests a common pathophysiologic mechanism at some level. The primary metabolic aberration in Reye syndrome is unknown. Viral, drug, and toxic precipitants in a conductive host alter glial and neuronal function, possibly by direct toxic effects or by altered transmitter metabolism and signal transduction. These events translate into a rather stereotyped progression of the clinical syndrome. Increased ICP, which is a life-threatening epiphenomenon, is the focus of conventional therapy. Investigational treatments, still in preliminary stages, are aimed at early correction of instigating metabolic abnormalities or correction of their consequences on central neurotransmission. Our fragmentary knowledge of neurotransmitter abnormalities in this disorder, which have suggested disparate interpretations, does not allow a cohesive pharmacologic theory of Reye syndrome. The greatest difficulties in interpretation of possible central mechanisms from existing data, which derive largely from peripheral tissues, is in the differentiation of primary from compensatory changes. The unitarian notion that a single pharmacologic disturbance is the source of the encephalopathy is perhaps too simplistic. It is hoped that future studies of disorders such as Reye syndrome will elucidate the intricate relationships between biochemical pathways and neurotransmitter metabolism.

  10. Tracing the policy implementation of commitments made by national governments and other entities at the Third Global Forum on Human Resources for Health.

    Science.gov (United States)

    van de Pas, Remco; Veenstra, Anika; Gulati, Daniel; Van Damme, Wim; Cometto, Giorgio

    2017-01-01

    We conducted a follow-up analysis of the implementation of the Human Resources for Health (HRH) commitments made by country governments and other actors at the Third Global Forum on HRH in 2013. Since then member states of the WHO endorsed Universal Health Coverage as the main policy objective whereby health systems strengthening, including reinforcement of the health workforce, can contribute to several Sustainable Development Goals. Now is the right time to trace the implementation of these commitments and to assess their contribution to broader global health objectives. The baseline data for this policy tracing study consist of the categorisation and analysis of the HRH commitments conducted in 2014. This analysis was complemented in application of the health policy triangle as its main analytical framework. An online survey and a guideline for semistructured interviews were developed to collect data. Information on the implementation of the commitments is available in 49 countries (86%). The need for multi-actor approaches for HRH policy development is universally recognised. A suitable political window and socioeconomic situation emerge as crucial factors for sustainable HRH development. However, complex crises in different parts of the world have diverted attention from investment in HRH development. The analysis indicates that investment in the health workforce and corresponding policy development relies on political leadership, coherent government strategies, institutional capacity and intersectoral governance mechanisms. The institutional capacity to shoulder such complex tasks varies widely across countries. For several countries, the commitment process provided an opportunity to invest in, develop and reform the health workforce. Nevertheless, the quality of HRH monitoring mechanisms requires more attention. In conclusion, HRH challenges, their different pathways and the intersectorality of the required responses are a concern for all the countries

  11. The potential of translational bioinformatics approaches for pharmacology research.

    Science.gov (United States)

    Li, Lang

    2015-10-01

    The field of bioinformatics has allowed the interpretation of massive amounts of biological data, ushering in the era of 'omics' to biomedical research. Its potential impact on pharmacology research is enormous and it has shown some emerging successes. A full realization of this potential, however, requires standardized data annotation for large health record databases and molecular data resources. Improved standardization will further stimulate the development of system pharmacology models, using translational bioinformatics methods. This new translational bioinformatics paradigm is highly complementary to current pharmacological research fields, such as personalized medicine, pharmacoepidemiology and drug discovery. In this review, I illustrate the application of transformational bioinformatics to research in numerous pharmacology subdisciplines. © 2015 The British Pharmacological Society.

  12. Can free open access resources strengthen knowledge-based emerging public health priorities, policies and programs in Africa?

    Science.gov (United States)

    Tambo, Ernest; Madjou, Ghislaine; Khayeka-Wandabwa, Christopher; Tekwu, Emmanuel N; Olalubi, Oluwasogo A; Midzi, Nicolas; Bengyella, Louis; Adedeji, Ahmed A; Ngogang, Jeanne Y

    2016-01-01

    Tackling emerging epidemics and infectious diseases burden in Africa requires increasing unrestricted open access and free use or reuse of regional and global policies reforms as well as timely communication capabilities and strategies. Promoting, scaling up data and information sharing between African researchers and international partners are of vital importance in accelerating open access at no cost. Free Open Access (FOA) health data and information acceptability, uptake tactics and sustainable mechanisms are urgently needed. These are critical in establishing real time and effective knowledge or evidence-based translation, proven and validated approaches, strategies and tools to strengthen and revamp health systems.  As such, early and timely access to needed emerging public health information is meant to be instrumental and valuable for policy-makers, implementers, care providers, researchers, health-related institutions and stakeholders including populations when guiding health financing, and planning contextual programs.

  13. Productive diversification in natural resource abundant countries : limitations, policies and the experience of Argentina in the 2000s

    NARCIS (Netherlands)

    L.A. Serino (Leandro)

    2009-01-01

    textabstractThe debate on the pattern of specialization in natural resource abundant countries has re-emerged as demand for raw materials and food products from the rapidly growing East Asian countries, speculation in financial markets, and changes in production techniques augmented the

  14. http://www.revistadestatistica.ro/index.php/effective-management-of-resources-for-environmental-protection-using-taxes-in-the-environmental-policy/

    Directory of Open Access Journals (Sweden)

    Claudia CĂPĂŢÎNĂ

    2014-03-01

    Full Text Available Establishment of environmental taxes, called green taxes or eco-taxes, are ways to internalize the environmental costs in the prices of goods or services, causing producers and consumers to use resources more efficiently and sustainably. Green taxes or Pigovian taxes, named after their inventor, Arthur Pigou are known as sin taxes and when are applied to the “sin” of pollution they may be called environmental taxes or eco-taxes. Sustainable development can not be sustained without the existence of adequate measures and effective for protection of the environment. The polluter pays principle is a principle embraced by all countries from the desire do not deplete environmental resources, some of which being non-renewable resources, to be used by future generations. Polluters are both individuals and legal entities who must to respond in one way or another for their irresponsible actions, compensating damages, protecting the environment and paying damages for any casualties. Green taxes can generate a tax reform. Any responsible person will try to manage in another way the resources when has to bear consequences. In this regard, the environment can be protected more effectively and more cost effective for citizens. The effects of irresponsible actions of some of us not only affect the environment but also all animals and vegetable bodies inclusive people.

  15. Planning, Plumbing, or Posturing? Explaining the Weakness of Human Resource Development Structures and Policies in South Africa

    Science.gov (United States)

    Allais, Stephanie; Marock, Carmel; Ngcwangu, Siphelo

    2017-01-01

    In South Africa, a national peak structure, the Human Resource Development Council, led by the Deputy President and consisting of key Cabinet Ministers, senior leaders from organised labour and business, community representatives, professional bodies and experts from research and higher education, was established to enable high-level coordination…

  16. Using the World Health Organization's 4S-Framework to Strengthen National Strategies, Policies and Services to Address Mental Health Problems in Adolescents in Resource-Constrained Settings

    Directory of Open Access Journals (Sweden)

    Cabral de Mello Meena

    2011-09-01

    Full Text Available Abstract Background Most adolescents live in resource-constrained countries and their mental health has been less well recognised than other aspects of their health. The World Health Organization's 4-S Framework provides a structure for national initiatives to improve adolescent health through: gathering and using strategic information; developing evidence-informed policies; scaling up provision and use of health services; and strengthening linkages with other government sectors. The aim of this paper is to discuss how the findings of a recent systematic review of mental health problems in adolescents in resource-constrained settings might be applied using the 4-S Framework. Method Analysis of the implications of the findings of a systematic search of the English-language literature for national strategies, policies, services and cross-sectoral linkages to improve the mental health of adolescents in resource-constrained settings. Results Data are available for only 33/112 [29%] resource-constrained countries, but in all where data are available, non-psychotic mental health problems in adolescents are identifiable, prevalent and associated with reduced quality of life, impaired participation and compromised development. In the absence of evidence about effective interventions in these settings expert opinion is that a broad public policy response which addresses direct strategies for prevention, early intervention and treatment; health service and health workforce requirements; social inclusion of marginalised groups of adolescents; and specific education is required. Specific endorsed strategies include public education, parent education, training for teachers and primary healthcare workers, psycho-educational curricula, identification through periodic screening of the most vulnerable and referral for care, and the availability of counsellors or other identified trained staff members in schools from whom adolescents can seek assistance for

  17. The impact of austerity on the health workforce and the achievement of human resources for health policies in Ireland (2008-2014).

    Science.gov (United States)

    Williams, Des; Thomas, Steve

    2017-09-11

    The global economic crisis saw recessionary conditions in most EU countries. Ireland's severe recession produced pro-cyclical health spending cuts. Yet, human resources for health (HRH) are the most critical of inputs into a health system and an important economic driver. The aim of this article is to evaluate how the Irish health system coped with austerity in relation to HRH and whether austerity allowed and/or facilitated the implementation of HRH policy. The authors employed a quantitative longitudinal trend analysis over the period 2008 to 2014 with Health Service Executive (HSE) staff database as the principal source. For the purpose of this study, heath service employment is defined as directly employed whole-time equivalent public service staffing in the HSE and other government agencies. The authors also examined the heath sector pay bill and sought to establish linkages between the main staff database and pay expenditure, as given in the HSE Annual Accounts and Financial Statements (AFS), and key HRH policies. The actual cut in total whole-time equivalent (WTE) of directly employed health services human resources over the period 2008 to 2014 was 8027 WTE, a reduction of 7.2% but substantially less than government claims. There was a degree of relative protection for frontline staffing decreasing by 2.9% between 2008 and 2014 and far less than the 18.5% reduction in other staff. Staff exempted from the general moratorium also increased by a combined 12.6%. Counter to stated policy, the decline in staffing of non-acute care was over double than in acute care. Further, the reduction in directly employed staff was to a great extent matched by a marked increase in agency spending. The cuts forced substantial HRH reductions and yet there was some success in pursuing policy goals, such as increasing the frontline workforce while reducing support staff and protection of some cadres. Nevertheless, other policies failed such as moving staff away from acute settings

  18. Availability and Quantity of Human and Material Resources of Nigerian Universities' HIV Youth Friendly Centres: Implication for Policy Implementation

    Directory of Open Access Journals (Sweden)

    A.G. Akintomide

    2017-12-01

    Full Text Available The study assessed the availability and quality of human and material resources at the Campus-based Youth Friendly Centres in Southwestern Nigeria. The survey research design was adopted and the study was carried out among ten counsellors and centre coordinators of Youth Friendly Centres in four higher institutions of learning in Southwest Nigeria using interview guide and observation checklist to collect data. The result revealed that there were no enough counsellors at the YFCs and some of the counsellors available at the centres did not have enough qualification to render HIV counselling. It was also revealed that material resources were moderately available at most of the centres but not up to the require standard stipulated by the World Health Organization.

  19. Pharmacological Profile of Quinoxalinone

    Directory of Open Access Journals (Sweden)

    Youssef Ramli

    2014-01-01

    Full Text Available Quinoxalinone and its derivatives are used in organic synthesis for building natural and designed synthetic compounds and they have been frequently utilized as suitable skeletons for the design of biologically active compound. This review covers updated information on the most active quinoxalinone derivatives that have been reported to show considerable pharmacological actions such as antimicrobial, anti-inflammatory, antidiabetic, antiviral, antitumor, and antitubercular activity. It can act as an important tool for chemists to develop newer quinoxalinone derivatives that may prove to be better agents in terms of efficacy and safety.

  20. Human resource for health reform in peri-urban areas: a cross-sectional study of the impact of policy interventions on healthcare workers in Epworth, Zimbabwe.

    Science.gov (United States)

    Taderera, Bernard Hope; Hendricks, Stephen James Heinrich; Pillay, Yogan

    2017-12-16

    The need to understand how healthcare worker reform policy interventions impact health personnel in peri-urban areas is important as it also contributes towards setting of priorities in pursuing the universal health coverage goal of health sector reform. This study explored the impact of post 2008 human resource for health reform policy interventions on healthcare workers in Epworth, a peri-urban community in Harare, Zimbabwe, and the implications towards health sector reform policy in peri-urban areas. The study design was exploratory and cross-sectional and involved the use of qualitative and quantitative methods in data collection, presentation, and analysis. A qualitative study in which data were collected through a documentary search, five key informant interviews, seven in-depth interviews, and five focus group discussions was carried out first. This was followed by a quantitative study in which data were collected through a documentary search and 87 semi-structured sample interviews with healthcare workers. Qualitative data were analyzed thematically whilst descriptive statistics were used to examine quantitative data. All data were integrated during analysis to ensure comprehensive, reliable, and valid analysis of the dataset. Three main factors were identified to help interpret findings. The first main factor consisted policy result areas that impacted most successfully on healthcare workers. These included the deployment of community health workers with the highest correlation of 0.83. Policy result areas in the second main factor included financial incentives with a correlation of 0.79, training and development (0.77), deployment (0.77), and non-financial incentives (0.75). The third factor consisted policy result areas that had the lowest satisfaction amongst healthcare workers in Epworth. These included safety (0.72), equipment and tools of trade (0.72), health welfare (0.65), and salaries (0.55). The deployment of community health volunteers impacted

  1. Epigenetics and pharmacology

    Science.gov (United States)

    Stefanska, Barbara; MacEwan, David J

    2015-01-01

    Recent advances in the understanding of gene regulation have shown there to be much more regulation of the genome than first thought, through epigenetic mechanisms. These epigenetic mechanisms are systems that have evolved to either switch off gene activity altogether, or fine-tune any existing genetic activation. Such systems are present in all genes and include chromatin modifications and remodelling, DNA methylation (such as CpG island methylation rates) and histone covalent modifications (e.g. acetylation, methylation), RNA interference by short interfering RNAs (siRNAs) and long non-coding RNAs (ncRNAs). These systems regulate genomic activity ‘beyond’ simple transcriptional factor inducer or repressor function of genes to generate mRNA. Epigenetic regulation of gene activity has been shown to be important in maintaining normal phenotypic activity of cells, as well as having a role in development and diseases such as cancer and neurodegenerative disorders such as Alzheimer's. Newer classes of drugs regulate epigenetic mechanisms to counteract disease states in humans. The reports in this issue describe some advances in epigenetic understanding that relate to human disease, and our ability to control these mechanisms by pharmacological means. Increasingly the importance of epigenetics is being uncovered – it is pharmacology that will have to keep pace. PMID:25966315

  2. Sustainable prevention of resource conflicts. Policy and research recommendations (report 5); Rohstoffkonflikte nachhaltig vermeiden. Forschungs- und Handlungsempfehlungen (Teilbericht 5)

    Energy Technology Data Exchange (ETDEWEB)

    Taenzler, Dennis; Westerkamp, Meike [Adelphi Research, Berlin (Germany); Supersberger, Nikolaus; Ritthoff, Michael; Bleischwitz, Raimund [Wuppertal Institut (Germany)

    2011-04-15

    Raw material conflict occurs in various forms: in the form of supply bottlenecks and crises, violent disputes, or even war; as well as due to the effects of environmental destruction, whereby the sources of people's livelihood are lost. Raw material conflict is a reality in many instances, but in others is merely postulated. On the one hand, the nature, strategic importance and price of raw materials influence potential conflict constellations. On the other hand, much depends on the management and governance of raw material resources and production, material flows, value creation chains and sources of financing, across a variety of levels. Existing research into raw material conflict in the field of oil, gas and valuable minerals reveals the multi-layered complexity of the issue as well as the necessity and possibilities of avoiding such conflict in a sustainable manner over the long term. This research landscape was the starting point for the study by adelphi and the Wuppertal Institute titled ''Sustainable Prevention of Resource Conflicts: Identifying and reducing international conflict risk relating to access to and use of raw materials''. The project has added to existing research and delivered new perspectives in relation to lithium and rare earths - resources which are of special relevance for future energy supply and planning - with a view to developing renewable energy sources and meeting ambitious climate protection goals. This report summarises the results of the research project and sets out recommendations. The project was sponsored by the German Federal Environmental Agency, and was conducted in the period between July 2008 and September 2010. The results are published in a total of eight reports which are briefly summarised here. (orig.)

  3. TAX TOOLS OF THE STATE POLICY(POLITICS AT DEVELOPMENT OF OIL-AND-GAS RESOURCES OF NEW REGIONS

    Directory of Open Access Journals (Sweden)

    V.E. Toskunina

    2007-12-01

    Full Text Available Development of oil-and-gas sector of economy of region and character of interaction between oil-and-gas sector and regional economy connected with tax system. In article the estimation of consequences of reforming of tax system in sphere of oil extraction and its influences on social and economic system of obtaining region is given. Methods and approaches of increase of efficiency of tax regulation of process of development of oil-and-gas resources of new regions are determined.

  4. Neuroethical issues in pharmacological cognitive enhancement.

    Science.gov (United States)

    Mohamed, Ahmed Dahir

    2014-09-01

    Neuroethics is an emerging field that in general deals with the ethics of neuroscience and the neuroscience of ethics. In particular, it is concerned with the ethical issues in the translation of neuroscience to clinical practice and in the public domain. Numerous ethical issues arise when healthy individuals use pharmacological substances known as pharmacological cognitive enhancers (PCEs) for non-medical purposes in order to boost higher-order cognitive processes such as memory, attention, and executive functions. However, information regarding their actual use, benefits, and harms to healthy individuals is currently lacking. Neuroethical issues that arise from their use include the unknown side effects that are associated with these drugs, concerns about the modification of authenticity and personhood, and as a result of inequality of access to these drugs, the lack of distributive justice and competitive fairness that they may cause in society. Healthy individuals might be coerced by social institutions that force them to take these drugs to function better. These drugs might enable or hinder healthy individuals to gain better moral and self-understanding and autonomy. However, how these drugs might achieve this still remains speculative and unknown. Hence, before concrete policy decisions are made, the cognitive effects of these drugs should be determined. The initiation of accurate surveys to determine the actual usage of these drugs by healthy individuals from different sections of the society is proposed. In addition, robust empirical research need to be conducted to delineate not only whether or not these drugs modify complex higher-order cognitive processes but also how they might alter important human virtues such as empathy, moral reasoning, creativity, and motivation in healthy individuals. WIREs Cogn Sci 2014, 5:533-549. doi: 10.1002/wcs.1306 For further resources related to this article, please visit the WIREs website. The author has declared no

  5. Linking material flow analysis and resource policy via future scenarios of in-use stock: an example for copper.

    Science.gov (United States)

    Gerst, Michael D

    2009-08-15

    A key aspect to achieving long-term resource sustainability is the development of methodologies that explore future material cycles and their environmental impact. Using a novel dynamic in-use stock model and scenario analysis, I analyzed the multilevel global copper cycle over the next 100 years. In 1990, the industrialized world had an in-use copper stock about twice as large as the developing world and a per capita in-use stock of about six times as large. By 2100, the developing world will have an in-use copper stock about three times as large as the industrialized world, but the industrialized world will maintain a per capita stock twice that of the developing world. Under a scenario of no material substitution or technological change in copper products, global in-use stock in 2100 will be about as large as currently known copper resources. However, current scrap recycling trends and exploration will alleviate absolute supply pressure but not environmental impacts from decreasing copper are grades. Additionally, unexpected emergent properties of dematerialization are observed from the in-use stock model that arise solely from the properties of stock dynamics, an infrequently discussed cause of dematerialization in the literature.

  6. Achieving the World Health Organization's vision for clinical pharmacology.

    Science.gov (United States)

    Martin, Jennifer H; Henry, David; Gray, Jean; Day, Richard; Bochner, Felix; Ferro, Albert; Pirmohamed, Munir; Mörike, Klaus; Schwab, Matthias

    2016-02-01

    Clinical pharmacology is a medical specialty whose practitioners teach, undertake research, frame policy, give information and advice about the actions and proper uses of medicines in humans and implement that knowledge in clinical practice. It involves a combination of several activities: drug discovery and development, training safe prescribers, providing objective and evidence-based therapeutic information to ethics, regulatory and pricing bodies, supporting patient care in an increasingly subspecialized arena where co-morbidities, polypharmacy, altered pharmacokinetics and drug interactions are common and developing and contributing to medicines policies for Governments. Clinical pharmacologists must advocate drug quality and they must also advocate for sustainability of the Discipline. However for this they need appropriate clinical service and training support. This Commentary discusses strategies to ensure the Discipline is supported by teaching, training and policy organizations, to communicate the full benefits of clinical pharmacology services, put a monetary value on clinical pharmacology services and to grow the clinical pharmacology workforce to support a growing clinical, academic and regulatory need. © 2015 The British Pharmacological Society.

  7. Pharmacologic management of myelofibrosis.

    Science.gov (United States)

    Leung, Michael; Highsmith, Kaitlin; Rexwinkle, Amber

    2017-12-01

    Myelofibrosis is a BCR-ABL-negative myeloproliferative neoplasm characterized by abnormal hematopoiesis. Alterations to the Janus kinase-signal transducer and activator of transcription pathway result in dysregulation of gene transcription and cell proliferation. Patients with symptomatic myelofibrosis present with a variety of signs and symptoms including, but not limited to myelosuppression, marked splenomegaly, abdominal discomfort, fatigue, and blood transfusion-dependence. Traditional myelosuppressive therapies including hydroxyurea, azacitidine, and cladribine aim to reduce constitutional symptoms and control the burden of disease. Immunomodulators can potentially reverse anemia associated with myelofibrosis, but are poorly tolerated by most patients. The novel Janus kinase 2 (JAK2) inhibitor, ruxolitinib, has demonstrated marked improvements to constitutional symptoms and splenomegaly. While survival benefit has not yet been demonstrated, continued research into pharmacologic management of myelofibrosis offers the promise of altering the course of disease progression.

  8. The pharmacology of salmeterol.

    Science.gov (United States)

    Johnson, M; Butchers, P R; Coleman, R A; Nials, A T; Strong, P; Sumner, M J; Vardey, C J; Whelan, C J

    1993-01-01

    Salmeterol was developed to provide prolonged bronchodilatation to control nocturnal symptoms and improve maintenance therapy in asthmatic patients. Salmeterol is > 10,000 times more lipophilic than salbutamol and has greater affinity for the beta 2-adrenoceptor. Membrane binding is non-competitive and dissociation is slow so that its effects last for many hours. Despite this, salmeterol does not accumulate in tissues. Its mechanism of action can be explained by binding to a specific exo-site domain of the beta 2-receptor protein to produce continuous stimulation of the active site of the receptor, which gives salmeterol a profile of pharmacological activity unlike that of other beta 2-agonists. Due to its potent and prolonged activation of beta 2-adrenoceptors in airway smooth muscle cells, endothelial cells, mast cells and epithelial cells, salmeterol induces prolonged bronchodilatation, reduced vascular permeability, inhibition of inflammatory mediators, stimulation of ciliary function and modulation of ion and water transport across the bronchial mucosa.

  9. Lack of resources a major obstacle in program implementation. Niigata declaration. Parliamentarians pledge to translate commitment into support for population policies.

    Science.gov (United States)

    1999-01-01

    This article presents the reaffirmation of the 96 parliamentarians from 28 countries during the international conference in Niigata, Japan, concerning their pledge in translating their commitment into supporting the population policies and development. The Programme of Action of the International Conference on Population and Development (ICPD) and the Cairo Declaration on Population and Development were embraced by the parliamentarians. The ICPD+5 process and the International Forum of Parliamentarians on ICPD Review were utilized in the guideline implementation of the ICPD Programme of Action. The governments were solicited to implement and monitor the progress of the ICPD Programme of Action in addressing the need for water, food, natural resources, environment and population, reproductive health and gender equality. Recognizing the inseparable relationship between population and sustainable development, governments were urge to ensure that international understanding and conventions must be consistent with the provision of food security and human survival. The organization implores the UN and the UN Population Fund to pursue its role in the formulation and implementation of population policies in different countries and regional organizations like the Association of South-East Asian Nations and the South Asian Association for Regional Cooperation. The goal of the Asian Forum of Parliamentarians on Population and Development is to address the population and developmental problems in a comprehensive and integral fashion and the development of a worldwide network of concerned parliamentarians for the promotion of peace, prosperity and equality.

  10. Pharmacological Activities of Hypnea musciformis

    African Journals Online (AJOL)

    Revd Dr Olaleye

    et al., 2000). Carrageenan is extensively used as a food additive in a wide range of products including cheese, cream, chocolate and ice creams. Its chief use is as a suspending and stabilizing agent, and has a number of pharmacological properties (Knutsen et al., 1995). Preliminary pharmacological investigation of the.

  11. Translating vaccine policy into action: a report from the Bill & Melinda Gates Foundation Consultation on the prevention of maternal and early infant influenza in resource-limited settings.

    Science.gov (United States)

    Ortiz, Justin R; Neuzil, Kathleen M; Ahonkhai, Vincent I; Gellin, Bruce G; Salisbury, David M; Read, Jennifer S; Adegbola, Richard A; Abramson, Jon S

    2012-11-26

    Immunization of pregnant women against influenza is a promising strategy to protect the mother, fetus, and young infant from influenza-related diseases. The burden of influenza during pregnancy, the vaccine immunogenicity during this period, and the robust influenza vaccine safety database underpin recommendations that all pregnant women receive the vaccine to decrease complications of influenza disease during their pregnancies. Recent data also support maternal immunization for the additional purpose of preventing disease in the infant during the first six months of life. In April 2012, the WHO Strategic Advisory Group of Experts (SAGE) on Immunization recommended revisions to the WHO position paper on influenza vaccines. For the first time, SAGE recommended pregnant women should be made the highest priority for inactivated seasonal influenza vaccination. However, the variable maternal influenza vaccination coverage in countries with pre-existing maternal influenza vaccine recommendations underscores the need to understand and to address the discrepancy between recommendations and implementation success. We present the outcome of a multi-stakeholder expert consultation on inactivated influenza vaccination in pregnancy. The creation and implementation of vaccine policies and regulations require substantial resources and capacity. As with all public health interventions, the existence of perceived and real risks of vaccination will necessitate effective and transparent risk communication. Potential risk allocation and sharing mechanisms should be addressed by governments, vaccine manufacturers, and other stakeholders. In resource-limited settings, vaccine-related issues concerning supply, formulation, regulation, evidence evaluation, distribution, cost-utility, and post-marketing safety surveillance need to be addressed. Lessons can be learned from the Maternal and Neonatal Tetanus Elimination Initiative as well as efforts to increase vaccine coverage among pregnant

  12. Constructing a Strategic, National Resource: European Policies and the Up-Scaling of Water Services in the Algarve, Portugal

    Science.gov (United States)

    Thiel, Andreas

    2010-07-01

    Water management has been significantly reshaped throughout recent decades in Europe and worldwide. Vivid examples of this restructuring include Southern European coastal zones which have been transformed into the European “pleasure periphery” over the last 40 years, requiring significant changes in water service provision. Taking it as an illustrative case of the Southern European coastal freshwater crisis and the way different European Member States have dealt with it, the article provides an account of the Algarve, indicative of typical Portuguese dynamics, and compares it with developments in other European countries. Expanding demands on water services in this region led to a crisis situation throughout the nineties, which was resolved by shifting physical infrastructures and competencies to the supra-local level. The re-scaling of water management was instrumental to expanding national control over the sector at the expense of local authorities and privatization. The national level used European funds and regulations to re-configure the institutional and infrastructure set-up in order to provide for tourism and agricultural expansion. Quality tourism was constructed as a decentral, hegemonic state spatial project, with the Algarvian’s entire water resource base being put at its disposal. The solution found illustrates a modified version of the supply side and surface water oriented “hydraulic paradigm” in Portugal: geared towards tourism and urban areas and the maintenance of irrigation agriculture. Delays in infrastructures, ideological preferences, maintaining national control over strategic water services and territoriality contributed towards the construction of water services as part of this hegemonic state spatial strategy for tourism expansion.

  13. [Pharmacology general concepts].

    Science.gov (United States)

    Carrillo Norte, Juan Antonio

    2010-01-01

    It is very important to have basic knowledge, a sufficient critical attitude and an adequate methodology so that a prescription becomes a rational decision and not a purely reflex action. Dispensing pharmaceuticals requires that health professionals have adequate professional development and information since from a health-social-economic perspective therapeutic errors and iatrogenic medicine lead to a very important resource expenditure.

  14. Pharmacological management of dermatomyositis.

    Science.gov (United States)

    Griger, Zoltán; Nagy-Vincze, Melinda; Dankó, Katalin

    2017-10-01

    Dermatomyositis is a rare heterogeneous systemic autoimmune disease with multiple organ involvement which can result in significant disability and mortality. Despite the lack of placebo-controlled trials, glucocorticoids are considered to be the mainstay of initial management. Treatment strategies are mainly based on uncontrolled studies, evidence based guidelines for treatments do not exist. Areas covered: This review provides an overview of the currently available pharmacological treatments in the field of dermatomyositis including conventional immunosuppressants, biologics and topical agents. The role of antibodies in different treatment responses of dermatomyositis related clinicoserological syndromes is also discussed. A PubMed search was performed in order to find relevant literature for this review. Expert commentary: Early recognition and intervention is essential to ameliorate disease outcome. Determination of antibodies provide a useful key in diagnosis, clinical manifestations, malignancy, prognosis, and treatment response and may lead to wider acceptance of personalized medicine. Corticosteroids with adjunctive steroid-sparing immunosuppressive therapies are recommended to treat disease activity, prevent mortality, and reduce long-term disability. Combinations of second-line therapies or newer third-line therapies are used in severe, refractory, or corticosteroid-dependent diseases. Further research is required to assess the role of new therapies.

  15. [Pharmacological treatment of obesity].

    Science.gov (United States)

    Gomis Barbará, R

    2004-01-01

    The pharmacological treatment of obesity should be considered when cannot be achieved a 10% weight loss with diet therapy and physical activity. The drugs effective in obesity treatment may act by different mechanisms such as reduction in food intake, inhibition of fat absorption, increase of thermogenesis and stimulation of adipocyte apoptosis. At present, we only have two marketed drugs for obesity treatment. Sibutramine is an inhibitor of norepinephrine, dopamine and serotonina reuptake which inhibits food intake and increases thermogenesis. Sibutramine administration for a year can induce a weight loss of 4-7%. Its main side effects are hypertension, headache, insomnia and constipation. Orlistat is an inhibitor of pancreatic lipase which is able to block the absorption of 30% of ingested fat. Its administration induces weight loss and reduction of ulterior weight regain. Also, this drug improves hypertension dyslipdaemia and helps to prevent diabetes in 52% of cases when administered over four years. The increase in frequency of stools and interference with vitamin absorption are its main side effects. Glucagon-like peptide 1, which increases insulin sensitivity and satiety, adiponectin and PPAR-gamma agonists which reduce insulin resistance and modulates adipocyte generation are the basis for future therapeutic approaches of obesity. Phosphatase inhibitors induce PPAR-gamma phosphorylation and UCP-1 expression leading to an increase in thermogenesis and reduction in appetite.

  16. The pharmacology of regenerative medicine.

    Science.gov (United States)

    Christ, George J; Saul, Justin M; Furth, Mark E; Andersson, Karl-Erik

    2013-07-01

    Regenerative medicine is a rapidly evolving multidisciplinary, translational research enterprise whose explicit purpose is to advance technologies for the repair and replacement of damaged cells, tissues, and organs. Scientific progress in the field has been steady and expectations for its robust clinical application continue to rise. The major thesis of this review is that the pharmacological sciences will contribute critically to the accelerated translational progress and clinical utility of regenerative medicine technologies. In 2007, we coined the phrase "regenerative pharmacology" to describe the enormous possibilities that could occur at the interface between pharmacology, regenerative medicine, and tissue engineering. The operational definition of regenerative pharmacology is "the application of pharmacological sciences to accelerate, optimize, and characterize (either in vitro or in vivo) the development, maturation, and function of bioengineered and regenerating tissues." As such, regenerative pharmacology seeks to cure disease through restoration of tissue/organ function. This strategy is distinct from standard pharmacotherapy, which is often limited to the amelioration of symptoms. Our goal here is to get pharmacologists more involved in this field of research by exposing them to the tools, opportunities, challenges, and interdisciplinary expertise that will be required to ensure awareness and galvanize involvement. To this end, we illustrate ways in which the pharmacological sciences can drive future innovations in regenerative medicine and tissue engineering and thus help to revolutionize the discovery of curative therapeutics. Hopefully, the broad foundational knowledge provided herein will spark sustained conversations among experts in diverse fields of scientific research to the benefit of all.

  17. Mitochondrial biogenesis: pharmacological approaches.

    Science.gov (United States)

    Valero, Teresa

    2014-01-01

    Organelle biogenesis is concomitant to organelle inheritance during cell division. It is necessary that organelles double their size and divide to give rise to two identical daughter cells. Mitochondrial biogenesis occurs by growth and division of pre-existing organelles and is temporally coordinated with cell cycle events [1]. However, mitochondrial biogenesis is not only produced in association with cell division. It can be produced in response to an oxidative stimulus, to an increase in the energy requirements of the cells, to exercise training, to electrical stimulation, to hormones, during development, in certain mitochondrial diseases, etc. [2]. Mitochondrial biogenesis is therefore defined as the process via which cells increase their individual mitochondrial mass [3]. Recent discoveries have raised attention to mitochondrial biogenesis as a potential target to treat diseases which up to date do not have an efficient cure. Mitochondria, as the major ROS producer and the major antioxidant producer exert a crucial role within the cell mediating processes such as apoptosis, detoxification, Ca2+ buffering, etc. This pivotal role makes mitochondria a potential target to treat a great variety of diseases. Mitochondrial biogenesis can be pharmacologically manipulated. This issue tries to cover a number of approaches to treat several diseases through triggering mitochondrial biogenesis. It contains recent discoveries in this novel field, focusing on advanced mitochondrial therapies to chronic and degenerative diseases, mitochondrial diseases, lifespan extension, mitohormesis, intracellular signaling, new pharmacological targets and natural therapies. It contributes to the field by covering and gathering the scarcely reported pharmacological approaches in the novel and promising field of mitochondrial biogenesis. There are several diseases that have a mitochondrial origin such as chronic progressive external ophthalmoplegia (CPEO) and the Kearns- Sayre syndrome (KSS

  18. How do the top 12 pharmaceutical companies operate safety pharmacology?

    Science.gov (United States)

    Ewart, Lorna; Gallacher, David J; Gintant, Gary; Guillon, Jean-Michel; Leishman, Derek; Levesque, Paul; McMahon, Nick; Mylecraine, Lou; Sanders, Martin; Suter, Willi; Wallis, Rob; Valentin, Jean-Pierre

    2012-09-01

    How does safety pharmacology operate in large pharmaceutical companies today? By understanding our current position, can we prepare safety pharmacology to successfully navigate the complex process of drug discovery and development? A short anonymous survey was conducted, by invitation, to safety pharmacology representatives of the top 12 pharmaceutical companies, as defined by 2009 revenue figures. A series of multiple choice questions was designed to explore group size, accountabilities, roles and responsibilities of group members, outsourcing policy and publication record. A 92% response rate was obtained. Six out of 11 companies have 10 to 30 full time equivalents in safety pharmacology, who hold similar roles and responsibilities; although the majority of members are not qualified at PhD level or equivalent. Accountabilities were similar across companies and all groups have accountability for core battery in vivo studies and problem solving activities but differences do exist for example with in vitro safety screening and pharmacodynamic/pharmokinetic modeling (PK/PD). The majority of companies outsource less than 25% of studies, with in vitro profiling being the most commonly outsourced activity. Finally, safety pharmacology groups are publishing 1 to 4 articles each year. This short survey has highlighted areas of similarity and differences in the way large pharmaceutical companies operate safety pharmacology. Copyright © 2012 Elsevier Inc. All rights reserved.

  19. Analysis of policy implications and challenges of the Cuban health assistance program related to human resources for health in the Pacific

    Directory of Open Access Journals (Sweden)

    Asante Augustine D

    2012-05-01

    Full Text Available Abstract Background Cuba has extended its medical cooperation to Pacific Island Countries (PICs by supplying doctors to boost service delivery and offering scholarships for Pacific Islanders to study medicine in Cuba. Given the small populations of PICs, the Cuban engagement could prove particularly significant for health systems development in the region. This paper reviews the magnitude and form of Cuban medical cooperation in the Pacific and analyses its implications for health policy, human resource capacity and overall development assistance for health in the region. Methods We reviewed both published and grey literature on health workforce in the Pacific including health workforce plans and human resource policy documents. Further information was gathered through discussions with key stakeholders involved in health workforce development in the region. Results Cuba formalised its relationship with PICs in September 2008 following the first Cuba-Pacific Islands ministerial meeting. Some 33 Cuban health personnel work in Pacific Island Countries and 177 Pacific island students are studying medicine in Cuba in 2010 with the most extensive engagement in Kiribati, the Solomon Islands, Tuvalu and Vanuatu. The cost of the Cuban medical cooperation to PICs comes in the form of countries providing benefits and paying allowances to in-country Cuban health workers and return airfares for their students in Cuba. This has been seen by some PICs as a cheaper alternative to training doctors in other countries. Conclusions The Cuban engagement with PICs, while smaller than engagement with other countries, presents several opportunities and challenges for health system strengthening in the region. In particular, it allows PICs to increase their health workforce numbers at relatively low cost and extends delivery of health services to remote areas. A key challenge is that with the potential increase in the number of medical doctors, once the local students

  20. Pharmacology Portal: An Open Database for Clinical Pharmacologic Laboratory Services.

    Science.gov (United States)

    Karlsen Bjånes, Tormod; Mjåset Hjertø, Espen; Lønne, Lars; Aronsen, Lena; Andsnes Berg, Jon; Bergan, Stein; Otto Berg-Hansen, Grim; Bernard, Jean-Paul; Larsen Burns, Margrete; Toralf Fosen, Jan; Frost, Joachim; Hilberg, Thor; Krabseth, Hege-Merete; Kvan, Elena; Narum, Sigrid; Austgulen Westin, Andreas

    2016-01-01

    More than 50 Norwegian public and private laboratories provide one or more analyses for therapeutic drug monitoring or testing for drugs of abuse. Practices differ among laboratories, and analytical repertoires can change rapidly as new substances become available for analysis. The Pharmacology Portal was developed to provide an overview of these activities and to standardize the practices and terminology among laboratories. The Pharmacology Portal is a modern dynamic web database comprising all available analyses within therapeutic drug monitoring and testing for drugs of abuse in Norway. Content can be retrieved by using the search engine or by scrolling through substance lists. The core content is a substance registry updated by a national editorial board of experts within the field of clinical pharmacology. This ensures quality and consistency regarding substance terminologies and classification. All laboratories publish their own repertoires in a user-friendly workflow, adding laboratory-specific details to the core information in the substance registry. The user management system ensures that laboratories are restricted from editing content in the database core or in repertoires within other laboratory subpages. The portal is for nonprofit use, and has been fully funded by the Norwegian Medical Association, the Norwegian Society of Clinical Pharmacology, and the 8 largest pharmacologic institutions in Norway. The database server runs an open-source content management system that ensures flexibility with respect to further development projects, including the potential expansion of the Pharmacology Portal to other countries. Copyright © 2016 Elsevier HS Journals, Inc. All rights reserved.

  1. A multi-reservoir based water-hydroenergy management model for identifying the risk horizon of regional resources-energy policy under uncertainties

    International Nuclear Information System (INIS)

    Zeng, X.T.; Zhang, S.J.; Feng, J.; Huang, G.H.; Li, Y.P.; Zhang, P.; Chen, J.P.; Li, K.L.

    2017-01-01

    Highlights: • A multi-reservoir system can handle water/energy deficit, flood and sediment damage. • A MWH model is developed for planning a water allocation and energy generation issue. • A mixed fuzzy-stochastic risk analysis method (MFSR) can handle uncertainties in MWH. • A hybrid MWH model can plan human-recourse-energy with a robust and effective manner. • Results can support adjusting water-energy policy to satisfy increasing demands. - Abstract: In this study, a multi-reservoir based water-hydroenergy management (MWH) model is developed for planning water allocation and hydroenergy generation (WAHG) under uncertainties. A mixed fuzzy-stochastic risk analysis method (MFSR) is introduced to handle objective and subjective uncertainties in MWH model, which can couple fuzzy credibility programming and risk management within a general two-stage context, with aim to reflect the infeasibility risks between expected targets and random second-stage recourse costs. The developed MWH model (embedded by MFSR method) can be applied to a practical study of WAHG issue in Jing River Basin (China), which encounters conflicts between human activity and resource/energy crisis. The construction of water-energy nexus (WEN) is built to reflect integrity of economic development and resource/energy conservation, as well as confronting natural and artificial damages such as water deficit, electricity insufficient, floodwater, high sedimentation deposition contemporarily. Meanwhile, the obtained results with various credibility levels and target-violated risk levels can support generating a robust plan associated with risk control for identification of the optimized water-allocation and hydroenergy-generation alternatives, as well as flood controls. Moreover, results can be beneficial for policymakers to discern the optimal water/sediment release routes, reservoirs’ storage variations (impacted by sediment deposition), electricity supply schedules and system benefit

  2. Modeling the Land Use/Cover Change in an Arid Region Oasis City Constrained by Water Resource and Environmental Policy Change using Cellular Automata Model

    Science.gov (United States)

    Hu, X.; Li, X.; Lu, L.

    2017-12-01

    Land use/cover change (LUCC) is an important subject in the research of global environmental change and sustainable development, while spatial simulation on land use/cover change is one of the key content of LUCC and is also difficult due to the complexity of the system. The cellular automata (CA) model had an irreplaceable role in simulating of land use/cover change process due to the powerful spatial computing power. However, the majority of current CA land use/cover models were binary-state model that could not provide more general information about the overall spatial pattern of land use/cover change. Here, a multi-state logistic-regression-based Markov cellular automata (MLRMCA) model and a multi-state artificial-neural-network-based Markov cellular automata (MANNMCA) model were developed and were used to simulate complex land use/cover evolutionary process in an arid region oasis city constrained by water resource and environmental policy change, the Zhangye city during the period of 1990-2010. The results indicated that the MANNMCA model was superior to MLRMCA model in simulated accuracy. These indicated that by combining the artificial neural network with CA could more effectively capture the complex relationships between the land use/cover change and a set of spatial variables. Although the MLRMCA model were also some advantages, the MANNMCA model was more appropriate for simulating complex land use/cover dynamics. The two proposed models were effective and reliable, and could reflect the spatial evolution of regional land use/cover changes. These have also potential implications for the impact assessment of water resources, ecological restoration, and the sustainable urban development in arid areas.

  3. PPD-QALY-an index for cost-effectiveness in orthopedics: providing essential information to both physicians and health care policy makers for appropriate allocation of medical resources.

    Science.gov (United States)

    Dougherty, Christopher P; Howard, Timothy

    2013-09-01

    Because of the increasing health care costs and the need for proper allocation of resources, it is important to ensure the best use of health benefits for sick and injured people of the population. An index or indicator is needed to help us quantify what is being spent so that comparisons with other options can be implemented. Cost-effective analysis seems to be well suited to provide this essential information to health care policy makers and those charged with distributing disability funds so that the proper allocation of resources can be achieved. There is currently no such index to show whether the benefits paid out are the most cost-effective. By comparing the quality-adjusted life year (QALY) of a treatment method to the disability an individual would experience, on the basis of lost wages as measure of disability, we provide decision makers more information for the basis of cost allocation in health care. To accomplish this, we describe a new term, the PPD-QALY (permanent partial disability-quality of life year). This term was developed to establish an index to which musculoskeletal care can be compared, to evaluate the cost-effectiveness of a treatment on the basis of the monetary value of the disability. This term serves to standardize the monetary value of an injury. Cost-effective analysis in arthroscopic surgery may prove to be a valuable asset in this role and to provide decision makers the information needed to determine the societal benefit from new arthroscopic procedures as they are developed and implemented.

  4. Analysis of human resources for health strategies and policies in 5 countries in Sub-Saharan Africa, in response to GFATM and PEPFAR-funded HIV-activities.

    Science.gov (United States)

    Cailhol, Johann; Craveiro, Isabel; Madede, Tavares; Makoa, Elsie; Mathole, Thubelihle; Parsons, Ann Neo; Van Leemput, Luc; Biesma, Regien; Brugha, Ruairi; Chilundo, Baltazar; Lehmann, Uta; Dussault, Gilles; Van Damme, Wim; Sanders, David

    2013-10-25

    Global Health Initiatives (GHIs), aiming at reducing the impact of specific diseases such as Human Immunodeficiency Virus (HIV), have flourished since 2000. Amongst these, PEPFAR and GFATM have provided a substantial amount of funding to countries affected by HIV, predominantly for delivery of antiretroviral therapy (ARV) and prevention strategies. Since the need for additional human resources for health (HRH) was not initially considered by GHIs, countries, to allow ARV scale-up, implemented short-term HRH strategies, adapted to GHI-funding conditionality. Such strategies differed from one country to another and slowly evolved to long-term HRH policies. The processes and content of HRH policy shifts in 5 countries in Sub-Saharan Africa were examined. A multi-country study was conducted from 2007 to 2011 in 5 countries (Angola, Burundi, Lesotho, Mozambique and South Africa), to assess the impact of GHIs on the health system, using a mixed methods design. This paper focuses on the impact of GFATM and PEPFAR on HRH policies. Qualitative data consisted of semi-structured interviews undertaken at national and sub-national levels and analysis of secondary data from national reports. Data were analysed in order to extract countries' responses to HRH challenges posed by implementation of HIV-related activities. Common themes across the 5 countries were selected and compared in light of each country context. In all countries successful ARV roll-out was observed, despite HRH shortages. This was a result of mostly short-term emergency response by GHI-funded Non-Governmental Organizations (NGOs) and to a lesser extent by governments, consisting of using and increasing available HRH for HIV tasks. As challenges and limits of short-term HRH strategies were revealed and HIV became a chronic disease, the 5 countries slowly implemented mid to long-term HRH strategies, such as formalisation of pilot initiatives, increase in HRH production and mitigation of internal migration of HRH

  5. Autoradiography in pharmacology and toxicology

    International Nuclear Information System (INIS)

    Anon.

    1977-01-01

    81 abstracts on autoradiography in pharmacology and toxicology were presented, divided into six sessions concerning: 1) methods 2) hormones and receptors, 3) drugs, 4) toxicology, 5) metals, 6) fetal distribution. (author)

  6. NASA 2010 Pharmacology Evidence Review

    Science.gov (United States)

    Steinberg, Susan

    2011-01-01

    In 2008, the Institute of Medicine reviewed NASA's Human Research Program Evidence in assessing the Pharmacology risk identified in NASA's Human Research Program Requirements Document (PRD). Since this review there was a major reorganization of the Pharmacology discipline within the HRP, as well as a re-evaluation of the Pharmacology evidence. This panel is being asked to review the latest version of the Pharmacology Evidence Report. Specifically, this panel will: (1) Appraise the descriptions of the human health-related risk in the HRP PRD. (2) Assess the relevance and comprehensiveness of the evidence in identifying potential threats to long-term space missions. (3) Assess the associated gaps in knowledge and identify additional areas for research as necessary.

  7. Quality management of pharmacology and safety pharmacology studies.

    Science.gov (United States)

    Spindler, Per; Seiler, Jürg P

    2002-04-01

    Pharmacology has traditionally been excluded from the mandatory application of good laboratory practice (GLP) principles. Consensus has been reached through the process of the International Conference on Harmonisation (ICH, Topic S7A) with regard to the definitions of the different types of pharmacology studies (ICH S7A): primary pharmacodynamic, secondary pharmacodynamic and safety pharmacology studies, and guidance on the quality standards (expectations for GLP conformity) for these study types have been provided. Primary pharmacodynamic studies are the only study types that are fully exempt from GLP requirements. Secondary pharmacodynamic and safety pharmacology studies are expected to be conducted to GLP quality standards -- preferably to full, formal GLP compliance, when results are used for human safety assessment. At the present time, regulatory authorities will most likely be prepared to exercise flexibility in their requirement for GLP compliance, however, if non-clinical studies used in human safety assessment are not formally in compliance with the principles of GLP, regulatory acceptance may not be guaranteed. Historically, the application of formal GLP standards in safety pharmacology studies appears to vary between test facilities, and a number of study components in safety pharmacology studies, e.g. ECG monitoring, may not always conform to formal GLP standards. Apparently, however, formal GLP standards for these study components can be implemented for a relatively low additional cost. Based on the guidance given in the ICH S7A guideline, it thus appears logical to recommend that test facilities and sponsors consider their organisation of safety pharmacology studies in view of sound study management and formal implementation of GLP, where needed. Organisation of study management should facilitate collaboration across scientific disciplines because a plethora of data, originating from basic pharmacodynamics, toxicology, kinetics, and metabolism, as

  8. [Pharmacological therapy of obesity].

    Science.gov (United States)

    Pagotto, Uberto; Vanuzzo, Diego; Vicennati, Valentina; Pasquali, Renato

    2008-04-01

    Obesity is reaching epidemic proportions worldwide and it is correlated with various comorbidities, among which the most relevant are diabetes mellitus, arterial hypertension, and cardiovascular diseases. Obesity management is a modern challenge because of the rapid evolution of unfavorable lifestyles and unfortunately there are no effective treatments applicable to the large majority of obese/overweight people. The current medical attitude is to treat the complications of obesity (e.g. dyslipidemia, hypertension, diabetes, and cardiovascular diseases). However, the potential of treating obesity is enormous, bearing in mind that a volitional weight loss of 10 kg is associated with important risk factor improvement: blood pressure -10 mmHg, total cholesterol -10%, LDL cholesterol -15%, triglycerides -30%, fasting glucose -50%, HDL cholesterol +8%. Drug treatment for obesity is an evolving branch of pharmacology, burdened by severe side effects and consequences of the early drugs, withdrawn from the market, and challenged by the lack of long-term data on the effect of medications on obesity-related morbidity and mortality, first of all cardiovascular diseases. In Europe three antiobesity drugs are currently licensed: sibutramine, orlistat, and rimonabant; important trials with clinical endpoints are ongoing for sibutramine and rimonabant. While waiting for their results, it is convenient to evaluate these drugs for their effects on body weight and cardiometabolic risk factors. Sibutramine is a centrally acting serotonin/noradrenaline reuptake inhibitor that mainly increases satiety. At the level of brown adipose tissue, sibutramine can also facilitate energy expenditure by increasing thermogenesis. The long-term studies (five) documented a mean differential weight reduction of 4.45 kg for sibutramine vs placebo. Considering the principal studies, attrition rate was 43%. This drug not only reduces body weight and waist circumference, but it decreases triglycerides and

  9. Quality management of pharmacology and safety pharmacology studies

    DEFF Research Database (Denmark)

    Spindler, Per; Seiler, Jürg P

    2002-01-01

    Pharmacology has traditionally been excluded from the mandatory application of good laboratory practice (GLP) principles. Consensus has been reached through the process of the International Conference on Harmonisation (ICH, Topic S7A) with regard to the definitions of the different types of pharm......Pharmacology has traditionally been excluded from the mandatory application of good laboratory practice (GLP) principles. Consensus has been reached through the process of the International Conference on Harmonisation (ICH, Topic S7A) with regard to the definitions of the different types...... of pharmacology studies (ICH S7A): primary pharmacodynamic, secondary pharmacodynamic and safety pharmacology studies, and guidance on the quality standards (expectations for GLP conformity) for these study types have been provided. Primary pharmacodynamic studies are the only study types that are fully exempt...... from GLP requirements. Secondary pharmacodynamic and safety pharmacology studies are expected to be conducted to GLP quality standards -- preferably to full, formal GLP compliance, when results are used for human safety assessment. At the present time, regulatory authorities will most likely...

  10. Quality management of pharmacology and safety pharmacology studies

    DEFF Research Database (Denmark)

    Spindler, Per; Seiler, Jürg P

    2002-01-01

    Pharmacology has traditionally been excluded from the mandatory application of good laboratory practice (GLP) principles. Consensus has been reached through the process of the International Conference on Harmonisation (ICH, Topic S7A) with regard to the definitions of the different types of pharm......Pharmacology has traditionally been excluded from the mandatory application of good laboratory practice (GLP) principles. Consensus has been reached through the process of the International Conference on Harmonisation (ICH, Topic S7A) with regard to the definitions of the different types...... management should facilitate collaboration across scientific disciplines because a plethora of data, originating from basic pharmacodynamics, toxicology, kinetics, and metabolism, as well as from clinical investigations, are involved in a safety pharmacology assessment. Applying formal GLP standards...

  11. Human resources for health planning and management in the Eastern Mediterranean region: facts, gaps and forward thinking for research and policy

    Directory of Open Access Journals (Sweden)

    Abdallah Ahmad

    2007-03-01

    Full Text Available Abstract Background The early decades of the 21st century are considered to be the era of human resources for health (HRH. The World Health Report (WHR 2006 launched the Health Workforce Decade (2006–2015, with high priority given for countries to develop effective workforce policies and strategies. In many countries in the Eastern Mediterranean Region (EMR, particularly those classified as Low and Low-Middle Income Countries (LMICs, the limited knowledge about the nature, scope, composition and needs of HRH is hindering health sector reform. This highlights an urgent need to understand the current reality of HRH in several EMR countries. The objectives of this paper are to: (1 lay out the facts on what we know about the HRH for EMR countries; (2 generate and interpret evidence on the relationship between HRH and health status indicators for LMICs and middle and high income countries (MHICs in the context of EMR; (3 identify and analyze the information gaps (i.e. what we do not know and (4 provide forward thinking by identifying priorities for research and policy. Methods The variables used in the analysis were: nurse and physician density, gross national income, poverty, female literacy, health expenditure, Infant Mortality Rate (IMR, Under 5 Mortality Rate (U5MR, Maternal Mortality Rate (MMR and Life Expectancy (LE. Univariate (charts, bivariate (Pearson correlation and multivariate analysis (linear regression was conducted using SPSS 14.0, besides a synthesis of HRH literature. Results Results demonstrate the significant disparities in physician and nurse densities within the EMR, particularly between LMICs and MHICs. Besides this, significant differences exist in health status indicators within the EMR. Results of the Pearson correlation revealed that physician and nurse density, as well as female literacy in EMR countries were significantly correlated with lower mortality rates and higher life expectancy. Results of the regression

  12. The Pharmacology of Regenerative Medicine

    Science.gov (United States)

    Saul, Justin M.; Furth, Mark E.; Andersson, Karl-Erik

    2013-01-01

    Regenerative medicine is a rapidly evolving multidisciplinary, translational research enterprise whose explicit purpose is to advance technologies for the repair and replacement of damaged cells, tissues, and organs. Scientific progress in the field has been steady and expectations for its robust clinical application continue to rise. The major thesis of this review is that the pharmacological sciences will contribute critically to the accelerated translational progress and clinical utility of regenerative medicine technologies. In 2007, we coined the phrase “regenerative pharmacology” to describe the enormous possibilities that could occur at the interface between pharmacology, regenerative medicine, and tissue engineering. The operational definition of regenerative pharmacology is “the application of pharmacological sciences to accelerate, optimize, and characterize (either in vitro or in vivo) the development, maturation, and function of bioengineered and regenerating tissues.” As such, regenerative pharmacology seeks to cure disease through restoration of tissue/organ function. This strategy is distinct from standard pharmacotherapy, which is often limited to the amelioration of symptoms. Our goal here is to get pharmacologists more involved in this field of research by exposing them to the tools, opportunities, challenges, and interdisciplinary expertise that will be required to ensure awareness and galvanize involvement. To this end, we illustrate ways in which the pharmacological sciences can drive future innovations in regenerative medicine and tissue engineering and thus help to revolutionize the discovery of curative therapeutics. Hopefully, the broad foundational knowledge provided herein will spark sustained conversations among experts in diverse fields of scientific research to the benefit of all. PMID:23818131

  13. Italian energy policy

    International Nuclear Information System (INIS)

    1988-01-01

    This document discusses problems associated with Italian energy policy; economic and industrial development as it relates to that policy is covered. Specific areas covered are: (1) the basis of Italy's new energy policy; (2) energy demand; (3) five objectives; (4) the electrical power system; (5) proposed action; and (6) energy resources

  14. Exploring the ocean for new drug developments: Marine pharmacology

    Directory of Open Access Journals (Sweden)

    Harshad Malve

    2016-01-01

    Full Text Available Disease ailments are changing the patterns, and the new diseases are emerging due to changing environments. The enormous growth of world population has overburdened the existing resources for the drugs. And hence, the drug manufacturers are always on the lookout for new resources to develop effective and safe drugs for the increasing demands of the world population. Seventy-five percentage of earth's surface is covered by water but research into the pharmacology of marine organisms is limited, and most of it still remains unexplored. Marine environment represents countless and diverse resource for new drugs to combat major diseases such as cancer or malaria. It also offers an ecological resource comprising a variety of aquatic plants and animals. These aquatic organisms are screened for antibacterial, immunomodulator, anti-fungal, anti-inflammatory, anticancer, antimicrobial, neuroprotective, analgesic, and antimalarial properties. They are used for new drug developments extensively across the world. Marine pharmacology offers the scope for research on these drugs of marine origin. Few institutes in India offer such opportunities which can help us in the quest for new drugs. This is an extensive review of the drugs developed and the potential new drug candidates from marine origin along with the opportunities for research on marine derived products. It also gives the information about the institutes in India which offer marine pharmacology related courses.

  15. Pharmacological approach to acute pancreatitis

    DEFF Research Database (Denmark)

    Bang, Ulrich-Christian; Semb, Synne; Nojgaard, Camilla

    2008-01-01

    The aim of the present review is to summarize the current knowledge regarding pharmacological prevention and treatment of acute pancreatitis (AP) based on experimental animal models and clinical trials. Somatostatin (SS) and octreotide inhibit the exocrine production of pancreatic enzymes and may...

  16. Chemotaxonomy and pharmacology of Gentianaceae

    DEFF Research Database (Denmark)

    Jensen, Søren Rosendal; Schripsema, Jan

    2002-01-01

    the remaining six are members of the Gentianeae. Based on the above results, a tentative list of chemical characteristics for the tribes of the Gentianaceae is presented. Finally, some pharmacologically interesting properties of plant extracts or compounds from taxa within Gentianaceae are listed....

  17. Ethnomedicinal uses, phytochemistry and pharmacological ...

    African Journals Online (AJOL)

    pharmacological properties of the genus, Kirkia. Alfred Maroyi. Department of Botany, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa ... extracts and their isolates are potential sources of modern medicines following future detailed studies to elucidate their mechanisms of action, toxicity and clinical trials.

  18. Pharmacology of Marihuana (Cannabis sativa)

    Science.gov (United States)

    Maickel, Roger P.

    1973-01-01

    A detailed discussion of marihuana (Cannabis sativa) providing the modes of use, history, chemistry, and physiologic properties of the drug. Cites research results relating to the pharmacologic effects of marihuana. These effects are categorized into five areas: behavioral, cardiovascular-respiratory, central nervous system, toxicity-toxicology,…

  19. Role of targeted policies in mainstreaming renewable energy in a resource constrained electricity system: A case study of Karnataka electricity system in India

    International Nuclear Information System (INIS)

    Amrutha, A.A.; Balachandra, P.; Mathirajan, M.

    2017-01-01

    India is aggressively pursuing its renewable energy capacity expansion goals. Targeted policies such as Feed-in Tariff (FIT), Renewable Purchase Obligation (RPO) and Renewable Energy Certificate (REC) are introduced to stimulate renewable energy capacity expansion as well as generation. Currently, Indian power utilities treat RPO targets as a cost-burden, and therefore there is prevalence of non-compliance. Even other policies, such as FIT and RECs, in their present form, have failed to influence increase in renewable electricity supply. This has lead us to raise an important question whether these policies are adequate for building a cost-effective renewable energy-based low carbon electricity system for India. In this paper, we discuss the impact of above targeted policies in increasing the share of renewable electricity generation in the case of Karnataka State Electricity System. Various scenarios are developed and analysed using mixed-integer programming model to study the impacts. The results suggest that optimally managed FIT and REC schemes can provide opportunities for utilities to benefit from reduced costs. Overall, the above policies are inadequate, and introduction of market-based incentives, which expand the scope of trading in renewable energy certificates, are essential to achieve the desired objectives. - Highlights: • Analysing impacts of targeted energy policies in increasing renewable electricity share. • Scenario analyses are used to study impact on costs, targets, shortages and compliance. • Current policies are inadequate to ensure renewable energy utilization beyond targets. • Policies are necessary to incentivise compliance and penalise non-compliance.

  20. Minerals, lands, and geology for the common defence and general welfare, Volume 1, Before 1879 : A history of public lands, federal science and mapping policy, and development of mineral resources in the United States

    Science.gov (United States)

    Rabbitt, Mary C.

    1979-01-01

    This volume, the first of a four-volume study, is concerned with events in the United States before the establishment of the U.S. Geological Survey, during the years in which geology evolved as a science and began to influence economic development and national policy. Subsequent volumes continue the story but focus on the Survey and its role in the events and developments of later years. The method of analysis demonstrates that knowledge of the Earth and its history, processes, and resources has provided a basis for intelligent economic development; also that geologists very soon realized that uncontrolled development of the land and other natural resources could not continue, that some limitations must be made on man's use of the Earth. The Geological Survey was established when public awareness of the need for balance between development and conservation of our resources was becoming evident. That balance is even more necessary now and in the future for the "general welfare" and "common defence" of the Nation. We can be grateful for the wisdom of our Founding Fathers in providing for publicly supported studies in earth science and engineering by well-trained and motivated scientists and engineers. Such studies, undertaken objectively in the search for facts, can continue to be of great value in the formulation and execution of wise policies to protect our environment and to maintain that balance between development and conservation of the natural resources.

  1. [Healthy pharmaceutical policy].

    Science.gov (United States)

    González Pier, Eduardo

    2008-01-01

    Today, the pharmaceutical industry is experiencing a profound transition. Globalization and technological advancement represent the principal pressures for change in the market, where it is increasingly more difficult for this type of industry to efficiently recoup the growing cost of innovation. Mexico needs to analyze the policy implications of these change factors and promote, in the pharmaceutical market, policies that maximize health gains on invested resources. Pharmaceutical policy offers a rare example for a complementary approach between a sound health policy and an efficient economic policy; that is, a "healthy pharmaceutical policy."

  2. Pharmacological potential of cerium oxidenanoparticles

    Science.gov (United States)

    Celardo, Ivana; Pedersen, Jens Z.; Traversa, Enrico; Ghibelli, Lina

    2011-04-01

    Nanotechnology promises a revolution in pharmacology to improve or create ex novo therapies. Cerium oxidenanoparticles (nanoceria), well-known as catalysts, possess an astonishing pharmacological potential due to their antioxidant properties, deriving from a fraction of Ce3+ ions present in CeO2. These defects, compensated by oxygen vacancies, are enriched at the surface and therefore in nanosized particles. Reactions involving redox cycles between the Ce3+ and Ce4+oxidation states allow nanoceria to react catalytically with superoxide and hydrogen peroxide, mimicking the behavior of two key antioxidant enzymes, superoxide dismutase and catalase, potentially abating all noxious intracellularreactive oxygen species (ROS) via a self-regenerating mechanism. Hence nanoceria, apparently well tolerated by the organism, might fight chronic inflammation and the pathologies associated with oxidative stress, which include cancer and neurodegeneration. Here we review the biological effects of nanoceria as they emerge from in vitro and in vivo studies, considering biocompatibility and the peculiar antioxidant mechanisms.

  3. Pharmacological Treatment for Atrial Fibrillation

    Directory of Open Access Journals (Sweden)

    Kaoru Sugi, MD PhD

    2005-01-01

    Full Text Available Pharmacological treatment for atrial fibrillation has a variety of purposes, such as pharmacological defibrillation, maintenance of sinus rhythm, heart rate control to prevent congestive heart failure and prevention of both cerebral infarction and atrial remodeling. Sodium channel blockers are superior to potassium channel blockers for atrial defibrillation, while both sodium and potassium channel blockers are effective in the maintenance of sinus rhythm. In general, digitalis or Ca antagonists are used to control heart rate during atrial fibrillation to prevent congestive heart failure, while amiodarone or bepridil also reduce heart rates during atrial fibrillation. Anticoagulant therapy with warfarin is recommended to prevent cerebral infarction and angiotensin converting enzyme antagonists or angiotensin II receptor blockers are also used to prevent atrial remodeling. One should select appropriate drugs for treatment of atrial fibrillation according to the patient's condition.

  4. Pharmacologic interventions in aging hair

    OpenAIRE

    Tr?eb, Ralph M

    2006-01-01

    The appearance of hair plays an important role in people?s overall physical appearance and self-perception. With today?s increasing life-expectations, the desire to look youthful plays a bigger role than ever. The hair care industry has become aware of this and is delivering active products directed towards meeting this consumer demand. The discovery of pharmacological targets and the development of safe and effective drugs also indicate strategies of the drug industry for maintenance of heal...

  5. The clinical pharmacology of acamprosate.

    Science.gov (United States)

    Kalk, Nicola J; Lingford-Hughes, Anne R

    2014-02-01

    Acamprosate is one of the few medications licensed for prevention of relapse in alcohol dependence, and over time it has proved to be significantly, if moderately, effective, safe and tolerable. Its use is now being extended into other addictions and neurodevelopmental disorders. The mechanism of action of acamprosate has been less clear, but in the decade or more that has elapsed since its licensing, a body of translational evidence has accumulated, in which preclinical findings are replicated in clinical populations. Acamprosate modulates N-methyl-d-aspartic acid receptor transmission and may have indirect effects on γ-aminobutyric acid type A receptor transmission. It is known to decrease brain glutamate and increase β-endorphins in rodents and man. Acamprosate diminishes reinstatement in ethanolized rodents and promotes abstinence in humans. Although acamprosate has been called an anticraving drug, its subjective effects are subtle and relate to diminished arousal, anxiety and insomnia, which parallel preclinical findings of decreased withdrawal symptoms in animals treated with acamprosate. Further understanding of the pharmacology of acamprosate will allow appropriate targeting of therapy in individuals with alcohol dependence and extension of its use to other addictions. © 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society.

  6. Equity and globalisation. On the necessity of equitable, sustainable global energy and resource policies; Gerechtigkeit und Globalisierung. Zur Notwendigkeit einer gerechten und nachhaltigen globalen Energie- und Ressourcenpolitik

    Energy Technology Data Exchange (ETDEWEB)

    Metzler, Anja

    2009-01-15

    The trend towards globalisation is steadily increasing and, whether directly or indirectly, gaining an influence on more and more areas of our lives. At the same time, more and more negative effects of human activities attending the globalisation process are becoming apparent, especially for poor populations, but also for future generations. One essential trait of globalisation is that no-one can flee from it - or, to be more precise, from the negative impact of the deeds done in its name. Globalisation therefore poses a global-scale equity problem. This can be demonstrated with particular clarity by reference to current global energy and resource policies. The foremost intent of this thesis therefore is to search for a more equitable and sustainable kind of globalisation than the one being practised at present. As we can learn from the political philosophy of international relations, this primarily requires an internationally binding code of behaviour or regulatory framework. Otherwise, as our present reality teaches us, whatever efforts are made, the outcome will be extremely meagre. This kind of commitment has been demanded on many occasions in the past. However, where it has been codified to date, this has largely only been in the form of inter-country peace orders. The most prominent writings to this end are those of John Rawls. However, theories such as his are no longer commensurate with the complexity of today's globalisation process. The author of the present dissertation therefore addresses the better known of the few approaches that go beyond Rawl's thinking, some of which evolved directly from a critical study of his writings. She deliberately also reviews some of the lesser known works. Based on a critical examination of the practicality of these approaches the author presents a draft for a binding global regulatory framework for the environment, economy and peace. [German] Globalisierungstendenzen nehmen immer staerker zu und beeinflussen

  7. Clinical Pharmacology in Denmark in 2016

    DEFF Research Database (Denmark)

    Brøsen, Kim; Andersen, Stig Ejdrup; Borregaard, Jeanett

    2016-01-01

    The Danish Society of Clinical Pharmacology was founded in 1976, and mainly thanks to the persistent efforts of the society, clinical pharmacology became an independent medical speciality in Denmark in 1996. Since then, clinical pharmacology has gone from strength to strength. In the Danish...... healthcare system, clinical pharmacology has established itself as an indispensible part of the efforts to promote the rational, safe and economic use of drugs. Clinical pharmacologists are active in drug committees both in hospitals and in the primary sector. All clinical pharmacology centres offer a local...... in the Capital Region. The Department of Clinical Pharmacology at Aarhus University Hospital works closely together with forensic toxicologists and pathologists, covering issues regarding illicit substances, forensic pharmacology, post-mortem toxicology, expert testimony and research. Therapeutic geriatric...

  8. Using Caenorhabditis elegans as a Model for Obesity Pharmacology Development.

    Science.gov (United States)

    Zheng, Jolene; Vasselli, Joseph R; King, Jason F; King, Michael L; We, Wenqian; Fitzpatrick, Zachary; Johnson, William D; Finley, John W; Martin, Roy J; Keenan, Michael J; Enright, Frederic M; Greenway, Frank L

    The Caenorhabditis elegans model is a rapid and inexpensive method to address pharmacologic questions. We describe the use of C. elegans to explore 2 pharmacologic questions concerning candidate antiobesity drugs and illustrate its potential usefulness in pharmacologic research: (1) to determine a ratio of betahistine-olanzapine that blocks the olanzapine-induced intestinal fat deposition (IFD) as detected by Nile red staining and (2) to identify the mechanism of action of a pharmaceutical candidate AB-101 that reduces IFD. Olanzapine (53 μg/mL) increased the IFD (12.1 ± 0.1%, P < 0.02), which was blocked by betahistine (763 μg/mL, 39.3 ± 0.01%, P < 0.05) in wild-type C. elegans (N2). AB-101 (1.0%) reduced the IFD in N2 (P < 0.05), increased the pharyngeal pumping rate (P < 0.05), and reversed the elevated IFD induced by protease inhibitors atazanavir and ritonavir (P < 0.05). AB-101 did not affect IFD in a ACS null mutant strain acs-4(ok2872) III/hT2[bli-4(e937) let-?(q782) qIs48](I;III) suggesting an involvement of the lipid oxidation pathway and an upregulation of CPT-1. Our studies suggest that C. elegans may be used as a resource in pharmacologic research. This article is intended to stimulate a greater appreciation of its value in the development of new pharmaceutical interventions.

  9. Net Resource Assessment (NetRA): A Collaborative Effort Between USGS Science and Decisions Center, the Science Impact Laboratory for Policy and Economics (University of New Mexico) and Sandia National Laboratory

    Science.gov (United States)

    Brookshire, D.; Bernknopf, R.; Adhikari, D. R.; Babis, C.; Broadbent, C. D.; Tidwell, V. C.

    2015-12-01

    Department of Interior Secretarial Order No. 3330, "… establishes a Department-wide mitigation strategy that will ensure consistency and efficiency in the review and permitting of infrastructure development projects and in conserving our Nation's valuable natural and cultural resources." The USGS Organic Act authorizes resource assessments to estimate the in-place potential capacity of energy, mineral, hydrologic, and biologic resources (20 Stat. 394; 43 U.S.C. 31) and later amendments. These two statements form the basis for the development of the Net Resources Assessment (NetRA) framework. NetRA is a policy-relevant, interdisciplinary approach to assessing natural resources availability in examining the regional-scale interrelationships between energy or mineral extraction and impact on ecosystem services. The systems dynamics approach (SD) emphasizes the interdependence of natural resource development and its effect on collocated ecosystem services over space and time. The example of the NetRA that will be presented focuses on tradeoffs associated with land management decisions in the West. The Piceance Basin, CO example that will be discussed involves development of a continuous gas deposit and its impact on Mule Deer and water quality. The SD is the hub for generating a range of simulated landscape outcomes. The probabilistic model provides an economic indicator as to the expected net societal benefit of economic development and biophysical indicators for ecosystem services affected in the region. Both natural and economic indicators are associated with each outcome via a tradeoff analysis the can be used for risk analysis. The NetRA also retains map attributes for before and after map comparisons to specific alternatives for an existing baseline. The model has three stages: map-based scenario development with slider bars (choice variables), side-by-side extraction and ecosystem services sub-models, and integrated multiple resource trade-off outcomes.

  10. Pharmacological approach to acute pancreatitis

    DEFF Research Database (Denmark)

    Bang, Ulrich-Christian; Semb, Synne; Nojgaard, Camilla

    2008-01-01

    The aim of the present review is to summarize the current knowledge regarding pharmacological prevention and treatment of acute pancreatitis (AP) based on experimental animal models and clinical trials. Somatostatin (SS) and octreotide inhibit the exocrine production of pancreatic enzymes and may...... be useful as prophylaxis against post endoscopic retrograde cholangiopancreatography pancreatitis (PEP). The protease inhibitor gabexate mesilate (GM) is used routinely as treatment to AP in some countries, but randomized clinical trials and a meta-analysis do not support this practice. Nitroglycerin (NGL...

  11. Gaultheria: Phytochemical and Pharmacological Characteristics

    Directory of Open Access Journals (Sweden)

    Ren-Bing Shi

    2013-09-01

    Full Text Available The genus Gaultheria, comprised of approximately 134 species, is mostly used in ethnic drugs to cure rheumatism and relieve pain. Phytochemical investigations of the genus Gaultheria have revealed the presence of methyl salicylate derivatives, C6-C3 constituents, organic acids, terpenoids, steroids, and other compounds. Methyl salicylate glycoside is considered as a characteristic ingredient in this genus, whose anti-rheumatic effects may have a new mechanism of action. In this review, comprehensive information on the phytochemistry, volatile components and the pharmacology of the genus Gaultheria is provided to explore its potential and advance research.

  12. Non pharmacological treatments in fibromyalgia

    Directory of Open Access Journals (Sweden)

    M. Spath

    2011-09-01

    Full Text Available To fully answer the complex question of what modes of non pharmacological treatments are useful for fibromyalgia (FM one should ask different layers of questions, and as with peeling layers of onions, be prepared to shed some tears. The first painful question, or layer of the onion, is related to understanding patients’ complaints. Patients who experience recurrent as well as persistent physical symptoms without any objective evidence are too often classified as “psychosomatic disorders” or worse as “non disease” (see Sarzi this issue...

  13. Global Environmental Problems: Implications for U.S. Policy. Tenth Edition. Teacher Resource Book [and Student Text]. Public Policy Debate in the Classroom. Choices for the 21st Century.

    Science.gov (United States)

    Fox, Sarah Cleveland

    Scientists have increasingly focused attention on far-reaching environmental threats, such as climate change, ozone depletion, and deforestation, that transcend national boundaries. A new concept, global environmental problems, has entered the public arena, particularly in the area of foreign policy and economic matters. This unit explores the…

  14. Pharmacology and drug development in rare diseases: the attractiveness and expertise of the French medical pharmacology.

    Science.gov (United States)

    Micallef, Joëlle; Boutouyrie, Pierre; Blin, Olivier

    2017-12-01

    Developing drugs for rare disease can be challenging due to specific rare disease characteristics. The French Medical Pharmacology is structured and positioned to play a major role in orphan drug research and development due to the required expertise concentrated into pharmacology departments, exclusively implemented within the French university hospitals, public hospitals that are linked to a medical school (and often a pharmacy school) with numerous INSERM or CNRS labelled research units. In addition, these structures allow a close collaboration between researchers, academic institutions and biotech start-up (most of them being spin-off of the academic structures). Also, within university hospitals are located the clinical investigation centres, linking to the F-CRIN network and also to Inserm and hospitals, that enable care staff and researchers to be associated and clinical research protocols to be carried out on site, in full respect with ethic and regulatory aspects. As a consequence, this intra and multidisciplinary expertise offers all resource to elaborate a tailored approach for orphan drug development, in new entities as well as in repositioning. For preclinical development: drug screening, candidate selection (taking into account PK, metabolism, variability and potential toxicity) and preclinical models (iPS, animal models) that could allow a better translation to human research. For clinical development, we will mention here dose determination, safety evaluation and Orphan Drug Designation and Protocol Assistance preparation and submission. For post marketing evaluation and surveys, the pharmacovigilance, addictovigilance and pharmacoepidemiology expertise, combined with access to large databases allow a better approach to orphan drug use and safety. As outlined through two success stories (Charcot Marie Tooth, vascular Ehlers-Danlos syndrome), the added value of French Medical Pharmacology structures and expertise has been evidenced in the know

  15. The Role of the Social Scientist in Human Resource Development Policy and Programs for Hispanics. National Symposium on Hispanics and CETA (1980).

    Science.gov (United States)

    Furino, Antonio, Ed.

    Conference speakers focused on three topics: Hispanics and Comprehensive Employment and Training Act (CETA) policy and implementation issues; data sources; and research regarding Hispanic manpower. After introductory remarks by James W. Wagener, Eli Ginzberg and Tomas Rivera, Ernest Green discussed Hispanics and CETA. Harry Greenspan described…

  16. Water SA: Editorial Policies

    African Journals Online (AJOL)

    Focus and Scope. This journal publishes refereed, original work in all branches of water science, technology, engineering and policy. This includes: water resource development; the hydrological cycle; surface hydrology; geohydrology, hydropedology and hydrometeorology; limnology; freshwater and estuarine ecology; ...

  17. Caffeine use in sports. A pharmacological review.

    Science.gov (United States)

    Sinclair, C J; Geiger, J D

    2000-03-01

    Caffeine is the most widely ingested psychoactive drug in the world. As many know, chronic use of caffeine leads to dependence, tolerance, drug craving, and upon abrupt cessation unpleasant withdrawal symptoms. Thus, caffeine fulfills pharmacological criteria by which agents are classified as drugs of abuse. Nevertheless, its use is legal and only at high, but readily attainable, levels is it banned from sport. Its use is widespread by athletes as young as 11 years of age who are seeking athletic advantage over fellow competitors. It is likely that its use will not decline any time soon because it is inexpensive, readily available, medically quite safe, socially acceptable, and by most measures legal. However, at levels allowed in sport, caffeine through its wide-ranging physiological and psychological effects increases endurance in well-trained athletes. If the goal of drug-testing and education programs in sport is to protect the health of athletes, prevent unfair advantage (cheating) and encourage ethical behavior then it seems obvious that the allowable levels of caffeine ingestion should be decreased. The alternative is to continue with policies designed largely to punish only those that get caught.

  18. Pharmacological cognitive enhancement in pediatrics.

    Science.gov (United States)

    Colaneri, Natalie; Sheldon, Mark; Adesman, Andrew

    2018-03-13

    Given the pervasiveness of psychotropic medication in the youth population and an increasingly competitive culture regarding educational performance, children, teenagers, and/or their parents may increasingly seek psychotropic substances in an effort to enhance a student's cognitive abilities and/or academic performance. Physicians must become aware of this very important and clinically relevant issue and work to ensure that medications remain in the hands of patients seeking wellness and not enhancement. The current article highlights findings on the pervasiveness of stimulant misuse and diversion in youth, the motivations and effects of stimulant use, health and legal consequences associated with use, and physician perceptions and preventive practices. Ethical concerns regarding pharmacological cognitive enhancement in pediatrics are also outlined - including coercion for nonusers, inequities in access, and threats to an individual's sense of self with regard to authenticity and autonomy. Pharmacological cognitive enhancement in pediatrics will become a larger, clinically relevant issue in the coming years. Physicians who care for children and adolescents must become more aware of this issue. Given the myriad health, legal, and ethical concerns, clinicians should discourage use of pharmaceuticals for enhancement purposes in the pediatric population.

  19. Pharmacologic therapy for acute pancreatitis

    Science.gov (United States)

    Kambhampati, Swetha; Park, Walter; Habtezion, Aida

    2014-01-01

    While conservative management such as fluid, bowel rest, and antibiotics is the mainstay of current acute pancreatitis management, there is a lot of promise in pharmacologic therapies that target various aspects of the pathogenesis of pancreatitis. Extensive review of preclinical studies, which include assessment of therapies such as anti-secretory agents, protease inhibitors, anti-inflammatory agents, and anti-oxidants are discussed. Many of these studies have shown therapeutic benefit and improved survival in experimental models. Based on available preclinical studies, we discuss potential novel targeted pharmacologic approaches that may offer promise in the treatment of acute pancreatitis. To date a variety of clinical studies have assessed the translational potential of animal model effective experimental therapies and have shown either failure or mixed results in human studies. Despite these discouraging clinical studies, there is a great clinical need and there exist several preclinical effective therapies that await investigation in patients. Better understanding of acute pancreatitis pathophysiology and lessons learned from past clinical studies are likely to offer a great foundation upon which to expand future therapies in acute pancreatitis. PMID:25493000

  20. Pharmacologic interventions in aging hair.

    Science.gov (United States)

    Trüeb, Ralph M

    2006-01-01

    The appearance of hair plays an important role in people's overall physical appearance and self-perception. With today's increasing life-expectations, the desire to look youthful plays a bigger role than ever. The hair care industry has become aware of this and is delivering active products directed towards meeting this consumer demand. The discovery of pharmacological targets and the development of safe and effective drugs also indicate strategies of the drug industry for maintenance of healthy and beautiful hair. Hair aging comprises weathering of the hair shaft, decrease of melanocyte function, and decrease in hair production. The scalp is subject to intrinsic and extrinsic aging. Intrinsic factors are related to individual genetic and epigenetic mechanisms with interindividual variation: prototypes are familial premature graying, and androgenetic alopecia. Currently available pharmacologic treatment modalities with proven efficacy for treatment of androgenetic alopecia are topical minoxidil and oral finasteride. Extrinsic factors include ultraviolet radiation and air pollution. Experimental evidence supports the hypothesis that oxidative stress also plays a role in hair aging. Topical anti-aging compounds include photoprotectors and antioxidants. In the absence of another way to reverse hair graying, hair colorants remain the mainstay of recovering lost hair color. Topical liposome targeting for melanins, genes, and proteins selectively to hair follicles are currently under investigation.

  1. A study on the role of nuclear energy in overcoming environment and resource crisis -For the establishment of sustainable energy policy-

    Energy Technology Data Exchange (ETDEWEB)

    Han, Pil Soon; Choi, Yung Myung; Ham, Chul Hoon; Cho, Il Hoon; Jung, Heum Soo; Lee, Tae Joon; Lee, Duk Sun [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1995-04-01

    This study is mainly composed of the analyses of the current circumstances and the future views on the global warming and the exhaustion of energy resources related to the use of energy, and the suggestion on the role of nuclear energy as the most prospective countermeasure on energy crisis. The effects of the problems of global warming and energy crisis on the 21st century are look upon and the strategies of each countries to their crises are analyzed in this study. In energy source and the characteristics of nuclear energy resource, and the necessity of the sustainable development of nuclear energy was emphasized. We suggested the enlargement of the development of nuclear energy in the aspects of the international trends, the national economic options and the deficiency of energy resources, and proposed the detail of the short - and long - term strategies on these matters. 22 figs, 39 tabs, 45 refs. (Author).

  2. Nuclear Non-Proliferation Policy Act of 1977. Hearings before the Subcommittee on Energy Research and Development of the Committee on Energy and Natural Resources, United States Senate, Ninety-Fifth Congress, First Session on S. 897 and S. 1432

    International Nuclear Information System (INIS)

    Anon.

    1978-01-01

    On April 7, 1977, President Carter announced his nuclear power policy. The policy statement set forth seven specific objectives for the future use of nuclear energy in this country and the rest of the world. The two proposed instruments for implementing this policy are the revised fiscal year 1978 ERDA authorization draft bill and S. 1432, the Nuclear Non-Proliferation Act of 1977. These legislative proposals are linked in that S. 1432 is designed to establish a non-proliferation framework with specific objectives established for the ERDA nuclear energy programs. The ERDA authorization bill is the budgetary vehicle to implement those objectives. The Committee on Energy and Natural Resources obtained joint referral of certain portions of the Nuclear Non-Proliferation Act to insure that non-proliferation policy is implemented in a manner consistent with the policy of having sufficient energy for this country and foreign countries in the future. The Subcommittee on Energy Research and Development must examine the costs and the consequences of various initiatives before they are implemented. F or example, the proposal to guarantee uranium enrichment services for foreign nations poses specific requirements on ERDA to expand considerably our enrichment capacity by the year 2000. Without reprocessing, it is expected that spent fuel rods from abroad will be returned to this country for storage with attendant costs and siting decisions. Also, international fuel-cycle evaluation programs must be carefully examined to insure that all options, including regional fuel cycle centers with international controls and inspection, are considered in seeking international approaches to the non-proliferation objectives. At the June 10 hearing, the subcommittee received testimony on S. 1432, the bill prepared by the administration. The hearings on September 13 and 14 focused on S. 897. Statements by many witnesses are included

  3. Human resource management

    OpenAIRE

    Šrolová, Tereza

    2012-01-01

    Human resource management is a deliberate approach to managing people who are employed in a particular organization and under the management leadership contribute to achieving organizational goals with their performance. Managing people is associated with personal strategy and policy,which have an important role in working with human resources. This issue is concerned in thesis. In the context of human resource management also deals with the culture of the organization and its influence on pe...

  4. Barriers and bottlenecks : a case study of the implementation of extension policy for enabling sustainable natural resource management in Queensland, Australia

    NARCIS (Netherlands)

    Leach, G.J.

    2012-01-01

    Internationally, extension has been a support instrument used by governments and commercial interests for improving agricultural production for hundreds, if not thousands of years. The application of extension theory and practice for natural resource management (NRM) is a more recent undertaking.

  5. The role of schools' perceived human resource policies in teachers' professional development activities: a comparative study of innovations toward competence-based education

    NARCIS (Netherlands)

    Prof. Dr. Rob F. Poell; Dr. Audrey Seezink

    2011-01-01

    The change toward competence-based education has implications for teachers as well as school management. This study investigates which professional development activities teachers undertake related to this change and how these activities differ among schools with various human resource (HR)

  6. Population policy.

    Science.gov (United States)

    1987-03-01

    decrease fertility, control international migration, and modify the spatial distribution of the population. To reduce its population growth rate, Pakistan has adopted a multi-sectoral, multidimensional approach to family planning. The policy of the government of the Philippines is to bring the population growth rate in line with the availability of natural resources and employment opportunities. In its 5-year plan covering 1982-86, the government of the Republic of Korea emphasized social development, attempting to more fully integrate population and development policies and programs within relevant sectors. To reduce its population growth rate to 1.3% by 1992, the government of Thailand is expanding the reach of its family planning program.

  7. Pharmacological challenges in chronic pancreatitis

    DEFF Research Database (Denmark)

    Olesen, Anne Estrup; Brokjaer, Anne; Fischer, Iben Wendelboe Deleuran

    2014-01-01

    . Together these factors can result in malabsorption and may also affect the efficacy of pharmacological intervention. The lifestyle of chronic pancreatitis patients may also contribute to gastrointestinal changes. Many patients limit their food intake because of the pain caused by eating and in some cases...... are often prescribed as pain treatment. Opioids have intrinsic effects on gastrointestinal motility and hence can modify the absorption of other drugs taken at the same time. Furthermore, the increased fluid absorption caused by opioids will decrease water available for drug dissolution and may hereby...... affect absorption of the drug. As stated above many factors can influence drug absorption and metabolism in patients with chronic pancreatitis. The factors may not have clinical relevance, but may explain inter-individual variations in responses to a given drug, in patients with chronic pancreatitis....

  8. Pharmacology of human experimental anxiety.

    Science.gov (United States)

    Graeff, F G; Parente, A; Del-Ben, C M; Guimarães, F S

    2003-04-01

    This review covers the effect of drugs affecting anxiety using four psychological procedures for inducing experimental anxiety applied to healthy volunteers and patients with anxiety disorders. The first is aversive conditioning of the skin conductance responses to tones. The second is simulated public speaking, which consists of speaking in front of a video camera, with anxiety being measured with psychometric scales. The third is the Stroop Color-Word test, in which words naming colors are painted in the same or in a different shade, the incongruence generating a cognitive conflict. The last test is a human version of a thoroughly studied animal model of anxiety, fear-potentiated startle, in which the eye-blink reflex to a loud noise is recorded. The evidence reviewed led to the conclusion that the aversive conditioning and potentiated startle tests are based on classical conditioning of anticipatory anxiety. Their sensitivity to benzodiazepine anxiolytics suggests that these models generate an emotional state related to generalized anxiety disorder. On the other hand, the increase in anxiety determined by simulated public speaking is resistant to benzodiazepines and sensitive to drugs affecting serotonergic neurotransmission. This pharmacological profile, together with epidemiological evidence indicating its widespread prevalence, suggests that the emotional state generated by public speaking represents a species-specific response that may be related to social phobia and panic disorder. Because of scant pharmacological data, the status of the Stroop Color-Word test remains uncertain. In spite of ethical and economic constraints, human experimental anxiety constitutes a valuable tool for the study of the pathophysiology of anxiety disorders.

  9. Pharmacology of human experimental anxiety

    Directory of Open Access Journals (Sweden)

    F.G. Graeff

    2003-04-01

    Full Text Available This review covers the effect of drugs affecting anxiety using four psychological procedures for inducing experimental anxiety applied to healthy volunteers and patients with anxiety disorders. The first is aversive conditioning of the skin conductance responses to tones. The second is simulated public speaking, which consists of speaking in front of a video camera, with anxiety being measured with psychometric scales. The third is the Stroop Color-Word test, in which words naming colors are painted in the same or in a different shade, the incongruence generating a cognitive conflict. The last test is a human version of a thoroughly studied animal model of anxiety, fear-potentiated startle, in which the eye-blink reflex to a loud noise is recorded. The evidence reviewed led to the conclusion that the aversive conditioning and potentiated startle tests are based on classical conditioning of anticipatory anxiety. Their sensitivity to benzodiazepine anxiolytics suggests that these models generate an emotional state related to generalized anxiety disorder. On the other hand, the increase in anxiety determined by simulated public speaking is resistant to benzodiazepines and sensitive to drugs affecting serotonergic neurotransmission. This pharmacological profile, together with epidemiological evidence indicating its widespread prevalence, suggests that the emotional state generated by public speaking represents a species-specific response that may be related to social phobia and panic disorder. Because of scant pharmacological data, the status of the Stroop Color-Word test remains uncertain. In spite of ethical and economic constraints, human experimental anxiety constitutes a valuable tool for the study of the pathophysiology of anxiety disorders.

  10. Pharmacological treatments in pathological gambling.

    Science.gov (United States)

    Grant, Jon E; Odlaug, Brian L; Schreiber, Liana R N

    2014-02-01

    Pathological gambling (PG) is a relatively common and often disabling psychiatric condition characterized by intrusive urges to engage in deleterious gambling behaviour. Although common and financially devastating to individuals and families, there currently exist no formally approved pharmacotherapeutic interventions for this disorder. This review seeks to examine the history of medication treatments for PG. A systematic review of the 18 double-blind, placebo-controlled pharmacotherapy studies conducted for the treatment of pathological gambling was conducted. Study outcome and the mean dose of medication administered was documented in an effort to determine a preferred medication choice in this population. A variety of medication classes have been examined in the treatment of PG with varying results. Antidepressants, atypical antipsychotics and mood stabilizers have demonstrated mixed results in controlled clinical trials. Although limited information is available, opioid antagonists and glutamatergic agents have demonstrated efficacious outcomes, especially for individuals with PG suffering from intense urges to engage in the behaviour. Given that several studies have demonstrated their efficacy in treating the symptoms associated with PG, opioid antagonists should be considered the first line treatment for PG at this time. Most published studies, however, have employed relatively small sample sizes, are of limited duration and involve possibly non-representative clinical groups (e.g. those without co-occurring psychiatric disorders). Response measures have varied across studies. Heterogeneity of PG treatment samples may also complicate identification of effective treatments. Identification of factors related to treatment response will help inform future studies and advance treatment strategies for PG. © 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society.

  11. Carotenoids: biochemistry, pharmacology and treatment.

    Science.gov (United States)

    Milani, Alireza; Basirnejad, Marzieh; Shahbazi, Sepideh; Bolhassani, Azam

    2017-06-01

    Carotenoids and retinoids have several similar biological activities such as antioxidant properties, the inhibition of malignant tumour growth and the induction of apoptosis. Supplementation with carotenoids can affect cell growth and modulate gene expression and immune responses. Epidemiological studies have shown a correlation between a high carotenoid intake in the diet with a reduced risk of breast, cervical, ovarian, colorectal cancers, and cardiovascular and eye diseases. Cancer chemoprevention by dietary carotenoids involves several mechanisms, including effects on gap junctional intercellular communication, growth factor signalling, cell cycle progression, differentiation-related proteins, retinoid-like receptors, antioxidant response element, nuclear receptors, AP-1 transcriptional complex, the Wnt/β-catenin pathway and inflammatory cytokines. Moreover, carotenoids can stimulate the proliferation of B- and T-lymphocytes, the activity of macrophages and cytotoxic T-cells, effector T-cell function and the production of cytokines. Recently, the beneficial effects of carotenoid-rich vegetables and fruits in health and in decreasing the risk of certain diseases has been attributed to the major carotenoids, β-carotene, lycopene, lutein, zeaxanthin, crocin (/crocetin) and curcumin, due to their antioxidant effects. It is thought that carotenoids act in a time- and dose-dependent manner. In this review, we briefly describe the biological and immunological activities of the main carotenoids used for the treatment of various diseases and their possible mechanisms of action. This article is part of a themed section on Principles of Pharmacological Research of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.11/issuetoc. © 2016 The British Pharmacological Society.

  12. Evaluation of a multi-year policy-focused intervention to increase physical activity and related behaviors in lower-resourced early care and education settings: Active Early 2.0

    Directory of Open Access Journals (Sweden)

    Emily J. Tomayko

    2017-12-01

    Full Text Available Physical activity is a critical component of obesity prevention, but few interventions targeting early childhood have been described. The Active Early guide was designed to increase physical activity in early care and education (ECE settings. The purpose of Active Early 2.0 was to evaluate the effectiveness of Active Early along with provider training, microgrant support, and technical assistance over 2 years (2012–2014 to increase physical activity and related behaviors (e.g., nutrition in settings serving a high proportion of children from underserved groups in recognition of significant disparities in obesity and challenges meeting physical activity recommendations in low-resource settings. The physical activity and nutrition environment were assessed before and after the intervention in 15 ECE settings in Wisconsin using the Environment and Policy Observation Assessment tool, and interviews were conducted with providers and technical consultants. There was no significant change in Total Physical Activity Score or any EPAO subscale over the intervention period; however, significant improvements in the Total Nutrition Score and the several Nutrition subscales were observed. Additionally, the percentage of sites with written activity policies significantly increased. Overall minutes of teacher-led physical activity increased to 61.5 ± 29.0 min (p < 0.05. Interviews identified key benefits to children (i.e., more energy, better rest, improved behavior and significant barriers, most notably care provider and child turnover and low parent engagement. Moderate policy and environmental improvements in physical activity and nutrition were achieved with this intervention, but more work is needed to understand and address barriers and to support sustained changes in lower-resource ECE settings.

  13. Evaluation of a multi-year policy-focused intervention to increase physical activity and related behaviors in lower-resourced early care and education settings:Active Early2.0.

    Science.gov (United States)

    Tomayko, Emily J; Prince, Ronald J; Hoiting, Jill; Braun, Abbe; LaRowe, Tara L; Adams, Alexandra K

    2017-12-01

    Physical activity is a critical component of obesity prevention, but few interventions targeting early childhood have been described. The Active Early guide was designed to increase physical activity in early care and education (ECE) settings. The purpose of Active Early 2.0 was to evaluate the effectiveness of Active Early along with provider training, microgrant support, and technical assistance over 2 years (2012-2014) to increase physical activity and related behaviors (e.g., nutrition) in settings serving a high proportion of children from underserved groups in recognition of significant disparities in obesity and challenges meeting physical activity recommendations in low-resource settings. The physical activity and nutrition environment were assessed before and after the intervention in 15 ECE settings in Wisconsin using the Environment and Policy Observation Assessment tool, and interviews were conducted with providers and technical consultants. There was no significant change in Total Physical Activity Score or any EPAO subscale over the intervention period; however, significant improvements in the Total Nutrition Score and the several Nutrition subscales were observed. Additionally, the percentage of sites with written activity policies significantly increased. Overall minutes of teacher-led physical activity increased to 61.5 ± 29.0 min (p care provider and child turnover and low parent engagement. Moderate policy and environmental improvements in physical activity and nutrition were achieved with this intervention, but more work is needed to understand and address barriers and to support sustained changes in lower-resource ECE settings.

  14. Health resources in a 200,000 urban Indian population argues the need for a policy on private sector health services

    Directory of Open Access Journals (Sweden)

    Kheya Melo Furtado

    2014-01-01

    Full Text Available Background: There are limited primary data on the number of urban health care providers in private practice in developing countries like India. These data are needed to construct and test models that measure the efficacy of public stewardship of private sector health services. Objective: This study reports the number and characteristics of health resources in a 200 000 urban population in Pune. Materials and Methods: Data on health providers were collected by walking through the 15.46 sq km study area. Enumerated data were compared with existing data sources. Mapping was carried out using a Global Positioning System device. Metrics and characteristics of health resources were analyzed using ArcGIS 10.0 and Statistical Package for the Social Sciences, Version 16.0 software. Results: Private sector health facilities constituted the majority (424/426, 99.5% of health care services. Official data sources were only 39% complete. Doctor to population ratios were 2.8 and 0.03 per 1000 persons respectively in the private and public sector, and the nurse to doctor ratio was 0.24 and 0.71, respectively. There was an uneven distribution of private sector health services across the area (2-118 clinics per square kilometre. Bed strength was forty-fold higher in the private sector. Conclusions: Mandatory registration of private sector health services needs to be implemented which will provide an opportunity for public health planners to utilize these health resources to achieve urban health goals.

  15. Nuclear Non-Proliferation Policy Act of 1977. Hearings before the Subcommittee on Energy Research and Development of the Committee on Energy and Natural Resources, United States Senate, Ninety-Fifth Congress, First Session, June 10, September 13, 14, 1977

    International Nuclear Information System (INIS)

    Anon.

    1978-01-01

    Senator Frank Church presented the opening statement on the June 10, 1977 hearing concerning the Nuclear Non-Proliferation Policy Act of 1977, S.1432. S.1432 is designed to establish a nonproliferation framework with specific objectives established for the ERDA nuclear energy programs. The ERDA authorization bill is the budgetary vehicle to implement these objectives. The Committee on Energy and Natural Resources obtained joint referral of certain portions of the Nuclear Non-Proliferation Act to insure that nonproliferation policy is implemented in a manner consistent with the policy of having sufficent energy for this country and foreign countries in the future. Additionally, the Subcommittee on Energy Research and Development must examine the cost and the consequences of various initiatives before they are implemented. For example, the proposal to guarantee uranium enrichment services for foreign nations poses specific requirements on ERDA to expand considerably our enrichment capacity by the year 2000. Without reprocessing, it is expected that spent fuel rods from abroad will be returned to this country for storage with attendant costs and siting decisions. Also, international fuel cycle evaluation programs must be carefully examined to insure that all options, including regional fuel cycle centers with international controls and inspection, are considered in seeking international approaches to the nonproliferation objectives. It is these and related questions to which the subcommittee seeks answers. The hearings on September 13 and 14 focused on S.897, a bill to strengthen U.S. policies on nonproliferation and to reorganize certain export functions of the Federal government to promote more efficient administration of such functions. Statements were presented by experts in government, private firms, and industrial sectors

  16. The Dutch vision of clinical pharmacology

    NARCIS (Netherlands)

    Schellens, J H M; Grouls, R; Guchelaar, H J; Touw, D J; Rongen, G A; de Boer, A; Van Bortel, L M

    Recent position papers addressing the profession of clinical pharmacology have expressed concerns about the decline of interest in the field among clinicians and medical educators in the United Kingdom and other Western countries, whether clinical pharmacology is actually therapeutics, and whether

  17. Pharmacologic study of irradiated fresh ginseng

    International Nuclear Information System (INIS)

    Wang Ziwen; Xu Dechun; Meng Lifen

    1992-01-01

    The pharmacologic effect of 2 kGy irradiated fresh ginseng juice on small white mouse was studied. The results showed that irradiated fresh ginsengs have significant effects against lack of oxygen, diuresis and fatigue of mice. The statistical analysis indicated that there was no marked difference of pharmacologic effect between irradiated fresh ginseng and raw fresh one

  18. Pharmacological modulation of SK3 channels

    DEFF Research Database (Denmark)

    Grunnet, M; Jespersen, Thomas; Angelo, K

    2001-01-01

    -frequency adaptation, pharmacological modulation of SK channels may be of significant clinical importance. Here we report the functional expression of SK3 in HEK293 and demonstrate a broad pharmacological profile for these channels. Brain slice studies commonly employ 4-aminopyridine (4-AP) to block voltage...

  19. The COMPASS study: a longitudinal hierarchical research platform for evaluating natural experiments related to changes in school-level programs, policies and built environment resources.

    Science.gov (United States)

    Leatherdale, Scott T; Brown, K Stephen; Carson, Valerie; Childs, Ruth A; Dubin, Joel A; Elliott, Susan J; Faulkner, Guy; Hammond, David; Manske, Steve; Sabiston, Catherine M; Laxer, Rachel E; Bredin, Chad; Thompson-Haile, Audra

    2014-04-08

    Few researchers have the data required to adequately understand how the school environment impacts youth health behaviour development over time. COMPASS is a prospective cohort study designed to annually collect hierarchical longitudinal data from a sample of 90 secondary schools and the 50,000+ grade 9 to 12 students attending those schools. COMPASS uses a rigorous quasi-experimental design to evaluate how changes in school programs, policies, and/or built environment (BE) characteristics are related to changes in multiple youth health behaviours and outcomes over time. These data will allow for the quasi-experimental evaluation of natural experiments that will occur within schools over the course of COMPASS, providing a means for generating "practice based evidence" in school-based prevention programming. COMPASS is the first study with the infrastructure to robustly evaluate the impact that changes in multiple school-level programs, policies, and BE characteristics within or surrounding a school might have on multiple youth health behaviours or outcomes over time. COMPASS will provide valuable new insight for planning, tailoring and targeting of school-based prevention initiatives where they are most likely to have impact.

  20. Complex Pharmacology of Free Fatty Acid Receptors

    DEFF Research Database (Denmark)

    Milligan, Graeme; Shimpukade, Bharat; Ulven, Trond

    2017-01-01

    G protein-coupled receptors (GPCRs) are historically the most successful family of drug targets. In recent times it has become clear that the pharmacology of these receptors is far more complex than previously imagined. Understanding of the pharmacological regulation of GPCRs now extends beyond...... pharmacology have shaped understanding of the complex pharmacology of receptors that recognize and are activated by nonesterified or "free" fatty acids (FFAs). The FFA family of receptors is a recently deorphanized set of GPCRs, the members of which are now receiving substantial interest as novel targets...... for the treatment of metabolic and inflammatory diseases. Further understanding of the complex pharmacology of these receptors will be critical to unlocking their ultimate therapeutic potential....

  1. How Can Synergism of Traditional Medicines Benefit from Network Pharmacology?

    Science.gov (United States)

    Yuan, Haidan; Ma, Qianqian; Cui, Heying; Liu, Guancheng; Zhao, Xiaoyan; Li, Wei; Piao, Guangchun

    2017-07-07

    Many prescriptions of traditional medicines (TMs), whose efficacy has been tested in clinical practice, have great therapeutic value and represent an excellent resource for drug discovery. Research into single compounds of TMs, such as artemisinin from Artemisia annua L., has achieved great success; however, it has become evident that a TM prescription (which frequently contains various herbs or other components) has a synergistic effect in effecting a cure or reducing toxicity. Network pharmacology targets biological networks and analyzes the links among drugs, targets, and diseases in those networks. Comprehensive, systematic research into network pharmacology is consistent with the perspective of holisticity, which is a main characteristic of many TMs. By means of network pharmacology, research has demonstrated that many a TM show a synergistic effect by acting at different levels on multiple targets and pathways. This approach effectively bridges the gap between modern medicine and TM, and it greatly facilitates studies into the synergistic actions of TMs. There are different kinds of synergistic effects with TMs, such as synergy among herbs, effective parts, and pure compounds; however, for various reasons, new drug discovery should at present focus on synergy among pure compounds.

  2. Pharmacology of HIV integrase inhibitors.

    Science.gov (United States)

    Adams, Jessica L; Greener, Benjamin N; Kashuba, Angela D M

    2012-09-01

    The purpose of this study is to review recent and relevant pharmacology data for three HIV integrase inhibitors: raltegravir (marketed), dolutegravir, and elvitegravir (both in phase III drug development). Data from January 2011 to April 2012 were evaluated. These data better characterized integrase inhibitor pharmacokinetics, assessed dosing regimens, and investigated previously undescribed drug-drug interactions. Due to formulation challenges, raltegravir inter-patient and intra-patient pharmacokinetic variability is high. Twice-daily 400  mg dosing has been shown to be clinically superior to 800  mg once-daily dosing. A pediatric formulation of raltegravir with less variable pharmacokinetics and greater bioavailability was US Food and Drug Administration (US FDA)-approved in December 2011. Cobicistat-boosted elvitegravir, and the second-generation integrase inhibitor dolutegravir, have lower pharmacokinetic variability and are dosed once daily. Dolutegravir drug interactions are similar to raltegravir, whereas boosted elvitegravir participates in additional CYP3A-mediated interactions. Raltegravir's potent antiretroviral activity has resulted in widespread use in both treatment-naïve and experienced patients. Dolutegravir and cobicistat-boosted elvitegravir have some pharmacokinetic advantages. Pharmacokinetic data in special populations (pregnancy, pediatrics) to optimize dosing are still required.

  3. Tiludronate: bone pharmacology and safety.

    Science.gov (United States)

    Bonjour, J P; Ammann, P; Barbier, A; Caverzasio, J; Rizzoli, R

    1995-11-01

    The pharmacological properties of tiludronate (4-chlorophenyl)thiomethylene bisphosphonate), a sulfured bisphosphonate, have been characterized in a series of preclinical in vivo and in vitro studies. In vivo, tiludronate exerts a dose-dependent inhibitory activity on bone resorption. This property was demonstrated in several animal models, including rats, ewes, and dogs, when bone resorption was induced by administration of retinoid acid or parathyroid hormone, or by immobilization, ovariectomy or orchidectomy. By uncoupling bone resorption from bone formation, tiludronate can induce a positive calcium and phosphate balance. When administered either continuously or intermittently to ovariectomized osteoporotic rats, tiludronate promotes a significant increase in bone mass. This positive effect is associated with an increase in mechanical resistance. Bone tolerance studies indicate that tiludronate is a safe compound with an appreciable therapeutic margin since it can effectively inhibit bone resorption without reducing bone mineralization and strength. In vitro, tiludronate added to bone tissue culture inhibits calcium release, lysosomal enzyme secretion and collagen matrix degradation when induced by various stimulators of bone resorption. At the cellular level, tiludronate does not appear to exert its inhibitory effect on bone resorption by impairing either the recruitment, the migration or the fusion of osteoclast precursors. Tiludronate could act on mature osteoclasts by reducing their capacity to secrete proton into the resorption space and also by favoring their detachment from the bone matrix. The available preclinical data indicate that tiludronate should be an efficacious bisphosphonate in the management of clinical conditions characterized by excessive bone resorption.

  4. [History and pharmacology of trazodone].

    Science.gov (United States)

    Agnoli, A

    1986-10-01

    Trazodone, a non-tricyclic molecule, represents the first of a new generation of antidepressants. It is currently marketed in a number of European countries, in the United States and in Latin America. The pharmacological and biochemical data, the mechanism of action and the preferential indications of trazodone are presented and compared to those of imipramine and other tricyclics. Unlike imipramine, trazodone inhibits the adrenergic system. The two molecules have anti-nociceptive properties, similar effects on the serotoninergic system and, after repeated administrations, they both reduce the density of beta-receptors. The clinical implications of the alpha-blocking activity of trazodone are reported. Trazodone is preferable to tricyclic anti-depressants in the treatment of depression in elderly subjects in general, and especially when they present closed angle glaucoma, prostatic hypertrophy, tremor or cardiovascular problems due to hyperactivity of the adrenergic system, as well as in organic depressions and in depression secondary to schizophrenia, alcoholism and in patients with Parkinson's disease.

  5. Herpes - resources

    Science.gov (United States)

    Genital herpes - resources; Resources - genital herpes ... following organizations are good resources for information on genital herpes : March of Dimes -- www.marchofdimes.com/pregnancy/complications- ...

  6. Parsing interindividual drug variability: an emerging role for systems pharmacology

    Science.gov (United States)

    Turner, Richard M; Park, B Kevin; Pirmohamed, Munir

    2015-01-01

    There is notable interindividual heterogeneity in drug response, affecting both drug efficacy and toxicity, resulting in patient harm and the inefficient utilization of limited healthcare resources. Pharmacogenomics is at the forefront of research to understand interindividual drug response variability, but although many genotype-drug response associations have been identified, translation of pharmacogenomic associations into clinical practice has been hampered by inconsistent findings and inadequate predictive values. These limitations are in part due to the complex interplay between drug-specific, human body and environmental factors influencing drug response and therefore pharmacogenomics, whilst intrinsically necessary, is by itself unlikely to adequately parse drug variability. The emergent, interdisciplinary and rapidly developing field of systems pharmacology, which incorporates but goes beyond pharmacogenomics, holds significant potential to further parse interindividual drug variability. Systems pharmacology broadly encompasses two distinct research efforts, pharmacologically-orientated systems biology and pharmacometrics. Pharmacologically-orientated systems biology utilizes high throughput omics technologies, including next-generation sequencing, transcriptomics and proteomics, to identify factors associated with differential drug response within the different levels of biological organization in the hierarchical human body. Increasingly complex pharmacometric models are being developed that quantitatively integrate factors associated with drug response. Although distinct, these research areas complement one another and continual development can be facilitated by iterating between dynamic experimental and computational findings. Ultimately, quantitative data-derived models of sufficient detail will be required to help realize the goal of precision medicine. WIREs Syst Biol Med 2015, 7:221–241. doi: 10.1002/wsbm.1302 PMID:25950758

  7. Review of the Chemistry and Pharmacology of 7-Methyljugulone ...

    African Journals Online (AJOL)

    Review of the Chemistry and Pharmacology of 7-Methyljugulone. ... Methods: The chemical and pharmacological data were retrieved from the well-known scientific websites such as Pubmed, Google Scholar, Reaxys, Scirus, Scopus, ... Keywords: 7-methyljugulone; biosynthesis; in vitro synthesis; pharmacology

  8. Problems of pharmacological supply of disaster medicine

    International Nuclear Information System (INIS)

    Sabaev, V.V.; Il'ina, S.L.

    1995-01-01

    The paper reviews a number of pharmacological problems, being important for the disaster medicine, of theoretical and practical nature, the settlement of which would promote more efficient rendering emergency medical aid to the injured persons in the conditions of emergency situations and further expert medical care. On the example of radiation accidents there are studied methodical approaches to organization of drug prophylaxis and therapy of the injured persons in emergency situations. The authors have proved the necessity of arranging proper pharmacological supply of disaster medicine which is to settle the whole complex of scientific-applied and organizational questions relating to the competence of pharmacology and pharmacy. 17 refs

  9. Statistical reporting of clinical pharmacology research.

    Science.gov (United States)

    Ring, Arne; Schall, Robert; Loke, Yoon K; Day, Simon

    2017-06-01

    Research in clinical pharmacology covers a wide range of experiments, trials and investigations: clinical trials, systematic reviews and meta-analyses of drug usage after market approval, the investigation of pharmacokinetic-pharmacodynamic relationships, the search for mechanisms of action or for potential signals for efficacy and safety using biomarkers. Often these investigations are exploratory in nature, which has implications for the way the data should be analysed and presented. Here we summarize some of the statistical issues that are of particular importance in clinical pharmacology research. © 2017 The British Pharmacological Society.

  10. [Contribution of animal experimentation to pharmacology].

    Science.gov (United States)

    Sassard, Jean; Hamon, Michel; Galibert, Francis

    2009-11-01

    Animal experimentation is of considerable importance in pharmacology and cannot yet be avoided when studying complex, highly integrated physiological functions. The use of animals has been drastically reduced in the classical phases of pharmacological research, for example when comparing several compounds belonging to the same pharmacological class. However, animal experiments remain crucial for generating and validating new therapeutic concepts. Three examples of such research, conducted in strict ethical conditions, will be used to illustrate the different ways in which animal experimentation has contributed to human therapeutics.

  11. [Non-pharmacological treatment of cognitive impairment].

    Science.gov (United States)

    Ramos Cordero, Primitivo; Yubero, Raquel

    2016-06-01

    This article reviews the effect of non-pharmacological therapies in persons with cognitive impairment, especially treatments aimed at brain stimulation and functional maintenance, since both pharmacological and non-pharmacological therapies affecting the cognitive and psychoaffective domains are reviewed in another article in this supplement. The article also discusses the close and reciprocal relationship between cognitive impairment, diet and nutritional status and describes the main nutritional risk factors and protective factors in cognitive decline. Copyright © 2016 Sociedad Española de Geriatría y Gerontología. Publicado por Elsevier España, S.L.U. All rights reserved.

  12. OECD Reviews of School Resources : Austria 2016

    OpenAIRE

    Theisens, Henno

    2016-01-01

    The effective use of school resources is a policy priority across OECD countries. The OECD Reviews of School Resources explore how resources can be governed, distributed, utilised and managed to improve the quality, equity and efficiency of school education. The series considers four types of resources: financial resources, such as public funding of individual schools; human resources, such as teachers, school leaders and education administrators; physical resources, such as location, buildin...

  13. Cost-effectiveness in orthopedics: providing essential information to both physicians and health care policy makers for appropriate allocation of medical resources.

    Science.gov (United States)

    Dougherty, Christopher P; Howard, Timothy

    2013-09-01

    Cost-effective analysis has become an important tool in helping determine what procedures are both cost-effective and appropriate in today's cost control health care. The quality-adjusted life-year (QALY) is a standard measure for health-related quality-of-life in medical cost-effectiveness research. It can be used to compare different interventions to determine the cost-effectiveness of each procedure. Use of QALY to compare health care interventions has become the new gold standard. The key words arthroscopy, cost-effectiveness analysis, QALY, shoulder, hip, knee, ankle, elbow, wrist, and pubic symphysis were searched utilizing PubMed and an internet search engine. Cost/QALY ratios were determined and compared with other surgical procedures using techniques other than arthroscopy. Cost/QALYs were found for the shoulder, hip, knee, and elbow. The QALY for the shoulder was $13,092, for a simple knee was $5783, for a hip $21,700, and for an elbow $2031. General costs were found for the ankle, wrist, and pubic symphysis, that could be used to estimate QALYs without the complex formal calculation. On the basis of our findings, arthroscopy is an extremely cost-effective allocation of health care resources.

  14. Pharmacological activities and pharmacokinetic study of hyperoside ...

    African Journals Online (AJOL)

    ... with no significant gender variation in its activities. Other significant details on its pharmacological properties and information for future investigations on its components are provided. Keywords: Hyperoside; Anti-inflammatory, Antidepressant, Neuroprotective, Antidiabetic, Anticancer, Antioxidant, Cytochrome P450 ...

  15. Bioanalysis, metabolism & clinical pharmacology of antiretroviral drugs

    NARCIS (Netherlands)

    Heine, R. ter

    2009-01-01

    The aims of all studies described in this thesis were to develop new bioanalytical and more patient friendly methods for studying the clinical pharmacology of antiretroviral drugs and to ultimately improve antiretroviral treatment.

  16. Synthesis, Spectroscopic and Pharmacological Studies of Bivalent ...

    African Journals Online (AJOL)

    Synthesis, Spectroscopic and Pharmacological Studies of Bivalent Copper, Zinc and Mercury Complexes of Thiourea. ... All the metal complexes were characterized by elemental chemical analysis, molar conductance, magnetic susceptibility measurements and IR spectroscopy. Cu(II) complexes were additionally ...

  17. Phytochemical, Toxicological and Pharmacological Studies of ...

    African Journals Online (AJOL)

    2015-01-23

    Jan 23, 2015 ... Department of Pharmacology and Toxicology, Metabolic Diseases Research Laboratory, School of Dentistry, Kyung Hee. University, Seoul ...... Stuppner H, Ganzera M. Determination of safrole in different Asarum species by headspace gas chromatography. Chromatographia 1998; 47: 685-. 688. 18.

  18. Punishment, Pharmacological Treatment, and Early Release

    DEFF Research Database (Denmark)

    Ryberg, Jesper

    2013-01-01

    Recent studies have shown that pharmacological treatment may have an impact on aggressive and impulsive behavior. Assuming that these results are correct, would it be morally acceptable to instigate violent criminals to accept pharmacological rehabilitation by offering this treatment in return...... relates to the acceptability of the fact that those criminals who accepted the treatment would be exempted from the punishment they rightly deserved. It is argued that none of these reasons succeeds in rejecting this sort of offer....

  19. The pharmacology of topical analgesics.

    Science.gov (United States)

    Barkin, Robert L

    2013-07-01

    Pain management of patients continues to pose challenges to clinicians. Given the multiple dimensions of pain--whether acute or chronic, mild, moderate, or severe, nociceptive or neuropathic--a multimodal approach may be needed. Fortunately, clinicians have an array of nonpharmacologic and pharmacologic treatment choices; however, each modality must be chosen carefully, because some often used oral agents are associated with safety and tolerability issues that restrict their use in certain patients. In particular, orally administered nonsteroidal antiinflammatory drugs, opioids, antidepressants, and anticonvulsants are known to cause systemic adverse effects in some patients. To address this problem, a number of topical therapies in various therapeutic classes have been developed to reduce systemic exposure and minimize the risks of patients developing adverse events. For example, topical nonsteroidal anti-inflammatory drug formulations produce a site-specific effect (ie, cyclo-oxygenase inhibition) while decreasing the systemic exposure that may lead to undesired effects in patients. Similarly, derivatives of acetylsalicylic acid (ie, salicylates) are used in topical analgesic formulations that do not significantly enter the patient's systemic circulation. Salicylates, along with capsaicin, menthol, and camphor, compose the counterirritant class of topical analgesics, which produce analgesia by activating and then desensitizing epidermal nociceptors. Additionally, patches and creams that contain the local anesthetic lidocaine, alone or co-formulated with other local anesthetics, are also used to manage patients with select acute and chronic pain states. Perhaps the most common topical analgesic modality is the cautious application of cutaneous cold and heat. Such treatments may decrease pain not by reaching the target tissue through systemic distribution, but by acting more directly on the affected tissue. Despite the tolerability benefits associated with avoiding

  20. Pharmacological interventions for acute pancreatitis.

    Science.gov (United States)

    Moggia, Elisabetta; Koti, Rahul; Belgaumkar, Ajay P; Fazio, Federico; Pereira, Stephen P; Davidson, Brian R; Gurusamy, Kurinchi Selvan

    2017-04-21

    In people with acute pancreatitis, it is unclear what the role should be for medical treatment as an addition to supportive care such as fluid and electrolyte balance and organ support in people with organ failure. To assess the effects of different pharmacological interventions in people with acute pancreatitis. We searched the Cochrane Central Register of Controlled Trials (CENTRAL, 2016, Issue 9), MEDLINE, Embase, Science Citation Index Expanded, and trial registers to October 2016 to identify randomised controlled trials (RCTs). We also searched the references of included trials to identify further trials. We considered only RCTs performed in people with acute pancreatitis, irrespective of aetiology, severity, presence of infection, language, blinding, or publication status for inclusion in the review. Two review authors independently identified trials and extracted data. We did not perform a network meta-analysis as planned because of the lack of information on potential effect modifiers and differences of type of participants included in the different comparisons, when information was available. We calculated the odds ratio (OR) with 95% confidence intervals (CIs) for the binary outcomes and rate ratios with 95% CIs for count outcomes using a fixed-effect model and random-effects model. We included 84 RCTs with 8234 participants in this review. Six trials (N = 658) did not report any of the outcomes of interest for this review. The remaining 78 trials excluded 210 participants after randomisation. Thus, a total of 7366 participants in 78 trials contributed to one or more outcomes for this review. The treatments assessed in these 78 trials included antibiotics, antioxidants, aprotinin, atropine, calcitonin, cimetidine, EDTA (ethylenediaminetetraacetic acid), gabexate, glucagon, iniprol, lexipafant, NSAIDs (non-steroidal anti-inflammatory drugs), octreotide, oxyphenonium, probiotics, activated protein C, somatostatin, somatostatin plus omeprazole, somatostatin

  1. 42 CFR 482.98 - Condition of participation: Human resources.

    Science.gov (United States)

    2010-10-01

    ... training of nursing staff and clinical transplant coordinators in the care of transplant patients and... team must demonstrate: (i) Knowledge of living organ donation, transplantation, medical ethics, and..., nursing, nutrition, social services, transplant coordination, and pharmacology. (f) Standard: Resource...

  2. The genus Polygonatum: A review of ethnopharmacology, phytochemistry and pharmacology.

    Science.gov (United States)

    Zhao, Ping; Zhao, Chengcheng; Li, Xia; Gao, Qingzhi; Huang, Luqi; Xiao, Peigen; Gao, Wenyuan

    2018-03-25

    and lectins. However, to clarify the chemical differences that lead to the different traditional uses between "Huangjing" (derived from P. sibiricum, P. kingianum, P. cyrtonema) and "Yuzhu" (derived from P. odoratum), a systematic comparison of the small molecule compositions and polysaccharides of these four species is needed. In addition to these four species, other locally used medicinal Polygonatum species should be the subject of research, and the chemical and pharmacological relationships of these species should be investigated to expand the medicinal resources and standardize the use of Polygonatum species. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. OECD Reviews of School Resources: Czech Republic 2016. OECD Reviews of School Resources

    Science.gov (United States)

    Shewbridge, Claire; Herczynski, Jan; Radinger, Thomas; Sonnemann, Julie

    2016-01-01

    The effective use of school resources is a policy priority across OECD countries. The "OECD Reviews of School Resources" explore how resources can be governed, distributed, utilised and managed to improve the quality, equity and efficiency of school education. The series considers four types of resources: financial resources, such as…

  4. Collection Development Policies in Community College Libraries.

    Science.gov (United States)

    Mesling, Chris Fowler

    2003-01-01

    Emphasizes the need for collection development policy in community college academic libraries. Highlights areas of resource sharing, community analysis, and collection assessment. Also provides an overview of how to create a collection for development policy, and recommends books on writing such policy. Includes model policy statements. (NB)

  5. Towards Improved Human Resource Development In Nigeria ...

    African Journals Online (AJOL)

    Towards Improved Human Resource Development In Nigeria: Challenges And Prospects. ... Journal of Research in National Development ... Consequently, the paper recommended; improved investment in education, implementable policies on human resource development, involvement of private organization in human ...

  6. ECONOMICS OF HUMAN RESOURCES

    Directory of Open Access Journals (Sweden)

    IOANA - JULIETA JOSAN

    2011-04-01

    Full Text Available The purpose of this paper is to analyze human resources in terms of quantitative and qualitative side with special focus on the human capital accumulation influence. The paper examines the human resources trough human capital accumulation in terms of modern theory of human resources, educational capital, health, unemployment and migration. The findings presented in this work are based on theoretical economy publications and data collected from research materials. Sources of information include: documents from organizations - the EUROSTAT, INSSE - studies from publications, books, periodicals, and the Internet. The paper describes and analyzes human resources characteristics, human resource capacities, social and economic benefits of human capital accumulation based on economy, and the government plans and policies on health, education and labor market.

  7. Neuroimmune Pharmacology, 2nd Edition - A Perspective.

    Science.gov (United States)

    Gelbard, Harris A

    2017-06-01

    It has been almost nine years since the 1st edition of Neuroimmune Pharmacology was published on May 23rd, 2008. The 2nd edition of Neuroimmune Pharmacology by Ikezu and Gendelman (Editors) with Przedborski, Masliah and Cosentino (Associate Editors) manages to fulfill two separate missions: to provide comprehensive, but highly topical access to a rapidly evolving field and to serve as a standalone reference for scientists and clinicians in need of guidance regarding questions pertinent to neuroimmune pharmacology. Doing a PubMed search on the terms neuroimmune and pharmacology yields 1090 publications, with a first publication by Dougherty and Dafny, published in the Journal of Neuroscience Research in 1988, entitled "Neuroimmune intercommunication, central opioids, and the immune response to bacterial endotoxin." Since 2000, there have been 979 publications using these search terms, with 137 published since the beginning of 2016. The obvious conclusion to be drawn is that this is a burgeoning field that represents the cusp between our understanding of relationships between the immune and nervous systems and how we might treat disease with pharmacologic approaches when normal homeostatic mechanisms go awry.

  8. Pharmacological stress agents in nuclear cardiology

    International Nuclear Information System (INIS)

    Buscombe, J.R.

    2004-01-01

    Treadmill test combined with myocardial perfusion scintigraphy (MPS) is a commonly used technique in the assessment of coronary artery disease. However there are a group of patients who may not be able to undergo treadmill tests. Patients with underlying conditions like neuromuscular disease, musculoskeletal disorder, heart failure and end-stage renal disease (ESRD) on renal dialysis would find it difficult to perform exercise on a treadmill or bicycle ergometer. These conditions prevent them from performing adequate exercise. Such patients would benefit from pharmacological stress procedures combined with MPS. Nuclear medicine departments use various pharmacological agents while performing stress tests on cardiac patients. The most commonly used pharmacological agents for cardiac stress are coronary vasodilators and catecholamines. In addition to these agents, adjuvant use of nitrates and atropine is also a common practice in nuclear cardiology. This review addresses various physiological and pharmacological properties of the commonly used pharmacological stress agents in MPS and critically analyses their advantages and disadvantages, as well as their safety and efficacy. (author)

  9. The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

    Science.gov (United States)

    Pawson, Adam J.; Sharman, Joanna L.; Benson, Helen E.; Faccenda, Elena; Alexander, Stephen P.H.; Buneman, O. Peter; Davenport, Anthony P.; McGrath, John C.; Peters, John A.; Southan, Christopher; Spedding, Michael; Yu, Wenyuan; Harmar, Anthony J.

    2014-01-01

    The International Union of Basic and Clinical Pharmacology/British Pharmacological Society (IUPHAR/BPS) Guide to PHARMACOLOGY (http://www.guidetopharmacology.org) is a new open access resource providing pharmacological, chemical, genetic, functional and pathophysiological data on the targets of approved and experimental drugs. Created under the auspices of the IUPHAR and the BPS, the portal provides concise, peer-reviewed overviews of the key properties of a wide range of established and potential drug targets, with in-depth information for a subset of important targets. The resource is the result of curation and integration of data from the IUPHAR Database (IUPHAR-DB) and the published BPS ‘Guide to Receptors and Channels’ (GRAC) compendium. The data are derived from a global network of expert contributors, and the information is extensively linked to relevant databases, including ChEMBL, DrugBank, Ensembl, PubChem, UniProt and PubMed. Each of the ∼6000 small molecule and peptide ligands is annotated with manually curated 2D chemical structures or amino acid sequences, nomenclature and database links. Future expansion of the resource will complete the coverage of all the targets of currently approved drugs and future candidate targets, alongside educational resources to guide scientists and students in pharmacological principles and techniques. PMID:24234439

  10. Molecular pharmacology of human NMDA receptors

    DEFF Research Database (Denmark)

    Hedegaard, Maiken; Hansen, Kasper Bø; Andersen, Karen Toftegaard

    2012-01-01

    current knowledge of the relationship between NMDA receptor structure and function. We summarize studies on the biophysical properties of human NMDA receptors and compare these properties to those of rat orthologs. Finally, we provide a comprehensive pharmacological characterization that allows side......-by-side comparison of agonists, un-competitive antagonists, GluN2B-selective non-competitive antagonists, and GluN2C/D-selective modulators at recombinant human and rat NMDA receptors. The evaluation of biophysical properties and pharmacological probes acting at different sites on the receptor suggest...... that the binding sites and conformational changes leading to channel gating in response to agonist binding are highly conserved between human and rat NMDA receptors. In summary, the results of this study suggest that no major detectable differences exist in the pharmacological and functional properties of human...

  11. Applications of stable isotopes in clinical pharmacology

    Science.gov (United States)

    Schellekens, Reinout C A; Stellaard, Frans; Woerdenbag, Herman J; Frijlink, Henderik W; Kosterink, Jos G W

    2011-01-01

    This review aims to present an overview of the application of stable isotope technology in clinical pharmacology. Three main categories of stable isotope technology can be distinguished in clinical pharmacology. Firstly, it is applied in the assessment of drug pharmacology to determine the pharmacokinetic profile or mode of action of a drug substance. Secondly, stable isotopes may be used for the assessment of drug products or drug delivery systems by determination of parameters such as the bioavailability or the release profile. Thirdly, patients may be assessed in relation to patient-specific drug treatment; this concept is often called personalized medicine. In this article, the application of stable isotope technology in the aforementioned three areas is reviewed, with emphasis on developments over the past 25 years. The applications are illustrated with examples from clinical studies in humans. PMID:21801197

  12. Tough Policies, Incredible Policies?

    OpenAIRE

    Andres Velasco; Alejandro Neut

    2003-01-01

    We revisit the question of what determines the credibility of macroeconomic policies here, of promises to repay public debt. Almost all thinking on the issue has focused on governments' strategic decision to default (or erode the value of outstanding debt via inflation/devaluation). But sometimes governments default not because they want to, but because they cannot avoid it: adverse shocks leave them no option. We build a model in which default/devaluation can occur deliberately (for strategi...

  13. Rhein: A Review of Pharmacological Activities.

    Science.gov (United States)

    Zhou, Yan-Xi; Xia, Wei; Yue, Wei; Peng, Cheng; Rahman, Khalid; Zhang, Hong

    2015-01-01

    Rhein (4, 5-dihydroxyanthraquinone-2-carboxylic acid) is a lipophilic anthraquinone extensively found in medicinal herbs, such as Rheum palmatum L., Cassia tora L., Polygonum multiflorum Thunb., and Aloe barbadensis Miller, which have been used medicinally in China for more than 1,000 years. Its biological activities related to human health are being explored actively. Emerging evidence suggests that rhein has many pharmacological effects, including hepatoprotective, nephroprotective, anti-inflammatory, antioxidant, anticancer, and antimicrobial activities. The present review provides a comprehensive summary and analysis of the pharmacological properties of rhein, supporting the potential uses of rhein as a medicinal agent.

  14. Rhein: A Review of Pharmacological Activities

    Directory of Open Access Journals (Sweden)

    Yan-Xi Zhou

    2015-01-01

    Full Text Available Rhein (4, 5-dihydroxyanthraquinone-2-carboxylic acid is a lipophilic anthraquinone extensively found in medicinal herbs, such as Rheum palmatum L., Cassia tora L., Polygonum multiflorum Thunb., and Aloe barbadensis Miller, which have been used medicinally in China for more than 1,000 years. Its biological activities related to human health are being explored actively. Emerging evidence suggests that rhein has many pharmacological effects, including hepatoprotective, nephroprotective, anti-inflammatory, antioxidant, anticancer, and antimicrobial activities. The present review provides a comprehensive summary and analysis of the pharmacological properties of rhein, supporting the potential uses of rhein as a medicinal agent.

  15. Ginsenoside Re: pharmacological effects on cardiovascular system.

    Science.gov (United States)

    Peng, Lu; Sun, Shi; Xie, Lai-Hua; Wicks, Sheila M; Xie, Jing-Tian

    2012-08-01

    Ginsenosides are the bioactive constituents of ginseng, a key herb in traditional Chinese medicine. As a single component of ginseng, ginsenoside Re (G-Re) belongs to the panaxatriol group. Many reports demonstrated that G-Re possesses the multifaceted beneficial pharmacological effects on cardiovascular system. G-Re has negative effect on cardiac contractility and autorhythmicity. It causes alternations in cardiac electrophysiological properties, which may account for its antiarrhythmic effect. In addition, G-Re also exerts antiischemic effect and induces angiogenic regeneration. In this review, we first outline the chemistry and the pharmacological effects of G-Re on the cardiovascular system. © 2011 Blackwell Publishing Ltd.

  16. [Pharmacological therapy of dependency on alcohol].

    Science.gov (United States)

    Alho, Hannu; Hyytiä, Petri

    2009-01-01

    Effective treatment choices for alcohol dependence have existed for long, but only a minor proportion of those dependent on alcohol seeks medical care and receives effective treatment. The biological mechanisms underlying the dependence and pharmacological means affecting them should be known in order to guarantee a successful pharmacological therapy of alcohol dependence. Therapy should be targeted depending on whether the goal is immediate total abstinence, gradual abstinence or maintaining of abstinence. The strongest scientific evidence for gradual abstinence exists for the opiate antagonist naltrexone. In attempting immediate total abstinence, a significant proportion of alcohol-dependent patients benefits from supervised disulfiram treatment.

  17. Role of clinical pharmacology in the development of antiplatelet drugs.

    Science.gov (United States)

    Patrono, Carlo

    2014-12-01

    This review discusses the role of clinical pharmacology in the development of low-dose aspirin and other antiplatelet agents during the past 30 years, emphasizing the main determinants of several success stories as well as of complete failures in the field. The author employs personal appraisal of the literature, with emphasis on personal contributions to the field. Low-dose aspirin provides an interesting paradigm of the independent development of a "new" antiplatelet agent by the medical/scientific community. Aspirin "resistance," improved dosing regimens for personalized therapy, and chemoprevention of colorectal cancer are thoroughly discussed. The industry-driven development paradigm includes 12 mechanism-based antiplatelet agents. Of those completing Phase 3, only 6 have been approved for the acute treatment or secondary prevention of atherothrombosis. Inadequate Phase 2 studies were largely involved in Phase 3 failures. The design of mechanism-based pharmacodynamic biomarkers and sophisticated Phase 2 investigations appear as an important key to successful drug development in this field. Clinical pharmacology has an excellent track record in this endeavor, and its role needs to be expanded, as suggested by the case studies discussed in this review. Finally, the choice of appropriate platelet-dependent end points and homogeneous clinical settings for Phase 3 trials not only represent desirable objectives for an integrated scientific and regulatory discussion but also deserve proper ethical consideration by all stakeholders to avoid an unacceptable burden of drug toxicity and an unsustainable waste of financial resources. Copyright © 2014 Elsevier HS Journals, Inc. All rights reserved.

  18. CancerHSP: anticancer herbs database of systems pharmacology

    Science.gov (United States)

    Tao, Weiyang; Li, Bohui; Gao, Shuo; Bai, Yaofei; Shar, Piar Ali; Zhang, Wenjuan; Guo, Zihu; Sun, Ke; Fu, Yingxue; Huang, Chao; Zheng, Chunli; Mu, Jiexin; Pei, Tianli; Wang, Yuan; Li, Yan; Wang, Yonghua

    2015-06-01

    The numerous natural products and their bioactivity potentially afford an extraordinary resource for new drug discovery and have been employed in cancer treatment. However, the underlying pharmacological mechanisms of most natural anticancer compounds remain elusive, which has become one of the major obstacles in developing novel effective anticancer agents. Here, to address these unmet needs, we developed an anticancer herbs database of systems pharmacology (CancerHSP), which records anticancer herbs related information through manual curation. Currently, CancerHSP contains 2439 anticancer herbal medicines with 3575 anticancer ingredients. For each ingredient, the molecular structure and nine key ADME parameters are provided. Moreover, we also provide the anticancer activities of these compounds based on 492 different cancer cell lines. Further, the protein targets of the compounds are predicted by state-of-art methods or collected from literatures. CancerHSP will help reveal the molecular mechanisms of natural anticancer products and accelerate anticancer drug development, especially facilitate future investigations on drug repositioning and drug discovery. CancerHSP is freely available on the web at http://lsp.nwsuaf.edu.cn/CancerHSP.php.

  19. Exhaustible resources and economic growth

    International Nuclear Information System (INIS)

    Campbell, H.F.

    1984-09-01

    This study examines the effect of a booming natural resource sector on regional economic growth, with particular attention to the impact of regional government policy on mineral rent taxation and the allocation of resource revenues. The author's approach is first to document the relevant theory and then apply it to the case of the uranium industry in Saskatchewan

  20. MANAGING AFRICA'S NATURAL RESOURCE ENDOWMENTS ...

    African Journals Online (AJOL)

    RAYAN_

    effective extraction of resources, notably supply chain bottlenecks. (transport logistics, business climate). Again, having the requisite capacities to track the impact of different economic policies, particularly those that help countries manage the boom and bust cycles inherent in dependency on natural resources, is.

  1. RESOURCE MATERIALS DEVELOPMENT IN ENVIRONMENTAL ...

    African Journals Online (AJOL)

    design and development of resource materials, describes the way in which ... teaching and learning practices, resource materials and other ... As such they offer potential for educational transformation from within the educational arena. Policy, curriculum and materials development decisions are often made without enough ...

  2. Creating Adaptive Policies

    International Development Research Centre (IDRC) Digital Library (Canada)

    Signs of the imperative for adaptive policy-making are coming from all sectors of our economy including healthcare, transportation, business, information technology, energy, international development, agriculture and natural resources management, to name but a few. We highlight these examples in the following sections ...

  3. Environment based innovation: policy questions

    Directory of Open Access Journals (Sweden)

    Mario Rui Silva

    2009-12-01

    Full Text Available Natural resources and physical cultural resources, referred to in this paper as “Environmental Resources”, can be important assets for regional competitiveness and innovation. In recent years, these types of assets have been increasingly taken into consideration in the design and implementation of regional development strategies, as a consequence of their potential role as a source of differentiation and of new competitive advantages. However, in contrast to environmental policies, which usually focus on the protection of the environment, innovation policies and their instruments are largely shaped by, and geared towards, knowledge-based innovation.In this paper, we discuss the role played by environmental resources in the context of regional innovation policies. We begin by discussing the relationship between environmental resources and regional development, and by emphasizing some contrasting views with regard to the function of environmental resources in regional development. Then, we address the relationship between regional competitive advantages and innovation strategies. The specific issues and problems that arise whenever the aim is to attain competitive advantages through the valorisation of environmental resources constitute the core of section III. In that section, we highlight the specific characteristics of environmental resources and we discuss the applicability of the “natural resource curse” argument to the dynamics based on the valorisation of environmental resources. The reasons that justify public interventionas well as the difficulties concerning the adequate level of intervention (local / regional / national are also examined. The paper ends with some conclusions and policy implications.

  4. Supporting request acceptance with use policies

    NARCIS (Netherlands)

    King, T.C.; Van Riemsdijk, M.B.; Dignum, V.; Jonker, C.M.

    2015-01-01

    This paper deals with the problem of automating the contribution of resources owned by people to do work for others, whilst providing a means for owners of resources to maintain autonomy over how, when and to whom their resources are used with the specification of resource use policies. We give

  5. Delirium in the elderly: A systematic review of pharmacological and non-pharmacological treatments

    Directory of Open Access Journals (Sweden)

    Cecília Carboni Tardelli Cerveira

    Full Text Available ABSTRACT Delirium is a common disorder associated with poor prognosis, especially in the elderly. The impact of different treatment approaches for delirium on morbimortality and long-term welfare is not completely understood. OBJECTIVE: To determine the efficacy of pharmacological and non-pharmacological treatments in elderly patients with delirium. METHODS: This systematic review compared pharmacological and non-pharmacological treatments in patients over 60 years old with delirium. Databases used were: MEDLINE (PubMed, EMBASE, Cochrane CENTRAL and LILACS from inception to January 6th, 2016. RESULTS: A total of ten articles were selected. The six non-pharmacological intervention studies showed no impact on duration of delirium, mortality or institutionalization, but a decrease in severity of delirium and improvement in medium-term cognitive function were observed. The most commonly used interventions were temporal-spatial orientation, orientation to self and others, early mobilization and sleep hygiene. The four studies with pharmacological interventions found that rivastigmine reduced the duration of delirium, improved cognitive function and reduced caregiver burden; olanzapine and haloperidol decreased the severity of delirium; droperidol reduced length of hospitalization and improved delirium remission rate. CONCLUSION: Although the pharmacological approach has been used in the treatment of delirium among elderly, there have been few studies assessing its efficacy, involving a small number of patients. However, the improvements in delirium duration and severity suggest these drugs are effective in treating the condition. Once delirium has developed, non-pharmacological treatment seems less effective in controlling symptoms, and there is a lack of studies describing different non-pharmacological interventions.

  6. Forest policy reform in Brazil

    Science.gov (United States)

    S. Bauch; E. Sills; L.C. Rodriguez Estraviz; K. McGinley; F. Cubbage

    2009-01-01

    Rapid deforestation in the Brazilian Amazon, caused by economic, social, and policy factors, has focused global and national attention on protecting this valuable forest resource. In response, Brazil reformed its federal forest laws in 2006, creating new regulatory, development, and incentive policy instruments and institutions. Federal forestry responsibilities are...

  7. Water Policies of Turkey

    Directory of Open Access Journals (Sweden)

    Hakan Istanbulluoglu

    2011-06-01

    Full Text Available Water is one of our most critical resources. Civilization has historically flourished around major waterways. The most important uses of water are; agricultural, industrial and domestic use. This critical resource is under threat around the world. In the next 20 years, the quantity of water available to everyone is predicted to decrease by 30%. 40% of the world\\\\\\\\\\\\\\'s inhabitants currently have insufficient fresh water for minimal hygiene. In 2000 more than 2.2 million people died from waterborne diseases. Water politics is politics affected by water and water resources. There are connections between water resources, water systems, and international security and conflict. Today, water is a strategic resource in the globe and an important element in many political conflicts. Turkey can be faced severe water-stress in the near future. Therefore Turkey has to develop realistic and feasible water policy for future generations. [TAF Prev Med Bull 2011; 10(3.000: 327-338

  8. Communities, Livelihoods and Natural Resources : Action Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Communities, Livelihoods and Natural Resources : Action Research and Policy Change in Asia. Couverture du livre Communities, Livelihoods and Natural Resources: Action Research and Policy Change in. Directeur(s) : Stephen R. Tyler. Maison(s) d'édition : Practical Action Publishing, CRDI. 1 janvier 2006. ISBN :.

  9. Improving water resources management in Nigeria: policy ...

    African Journals Online (AJOL)

    Despite these noble giant strides by government, potable water supply for all is still uncertain. It is sad to note, however, that at this stage of the nation's development that there are varied and poorly coordinated groups and individual agencies participating in water supply programmes. These result in conflicts of efforts and ...

  10. Youth and the Workplace: Perspectives for the Coming Decade, 1979. Hearings before the Committee on Labor and Human Relations, United States Senate, Ninety-Sixth Congress, First Session, on To Examine the Transition from School to Work and Explore the Nature of Youth Employment and Unemployment to Gauge the Conditions, Trends, and Problems Likely to Affect Federal Labor and Human Resources Policy in the 1980's. October 23 and 24, 1979.

    Science.gov (United States)

    Congress of the U.S., Washington, DC. Senate Committee on Labor and Public Welfare.

    Proceedings are presented of hearings before the Committee on Labor and Human Resources (1) to examine the transition from school to work and explore the nature of youth employment and unemployment and (2) to gauge the conditions, trends and problems likely to affect federal labor and human resources policy in the 1980s. Among those testifying…

  11. ORIGINAL ARTICLES Pharmacological testing in Horner's syndrome

    African Journals Online (AJOL)

    ORIGINAL ARTICLES. Thompson and Mensher1 described the topical use of cocaine to confirm the diagnosis of Horner's syndrome and hydroxyamphetamine to distinguish between pre- and postganglionic causative lesions. For almost 40 years, these drugs have been the mainstay of pharmacological testing in Horner's ...

  12. Phytochemical Constituents and Pharmacological Activities of ...

    African Journals Online (AJOL)

    and pharmacological studies. It is used in traditional medicine, especially for wound healing, jaundice, blood purification, and as an antispasmodic. Chemical studies have underlined the presence of various classes of compounds, the main being triterpenoids, flavonoids, coumarines, quinones, volatile oil, carotenoids and ...

  13. Pharmacology profiling of chemicals and proteins

    DEFF Research Database (Denmark)

    Kringelum, Jens Vindahl

    as an alternative to experimentally obtained measurements. Here I present several different tools that aid pharmacology profiling of the two main classes of pharmaceuticals; chemicals (small molecules) and proteins (biopharmaceuticals). Biopharmaceuticals have the inherent risks of eliciting an immune response due...

  14. Clinical pharmacology of novel anticancer drug formulations

    NARCIS (Netherlands)

    Stuurman, F.E.

    2013-01-01

    Studies outlined in this thesis describe the impact of drug formulations on pharmacology of anticancer drugs. It consists of four parts and starts with a review describing the mechanisms of low oral bioavailability of anti-cancer drugs and strategies for improvement of the bioavailability. The

  15. Kinship and interaction in neuromuscular pharmacology

    NARCIS (Netherlands)

    Schiere, Sjouke

    2006-01-01

    The background of this thesis is presented in the introductory chapters and stafts with a brief history of neuromuscular relaxants. It is followed by a short description of the neuromuscular physiology and pharmacology in chapters 2 and 3, respectively. In chapter 4 the aim of the thesis is

  16. Molecular Pharmacology of CXCR4 inhibition

    DEFF Research Database (Denmark)

    Steen, Anne; Rosenkilde, Mette Marie

    2012-01-01

    pharmacology of well-known CXCR4 antagonists in order to augment the potency and affinity and to increase the specificity of future CXCR4-targeting compounds. In this chapter, binding modes of CXCR4 antagonists that have been shown to mobilize stem cells are discussed. In addition, comparisons between results...

  17. Pharmaceutical and pharmacological approaches for bioavailability

    Indian Academy of Sciences (India)

    Much research has been done to determine drug–drug and herb–drug interactions for improving the bioavailability of etoposide. The present article gives insight on pharmaceutical and pharmacological attempts made from time to time to overcome the erratic inter- and intra-patient variability for improving the bioavailability ...

  18. Systems Pharmacology in Small Molecular Drug Discovery.

    Science.gov (United States)

    Zhou, Wei; Wang, Yonghua; Lu, Aiping; Zhang, Ge

    2016-02-18

    Drug discovery is a risky, costly and time-consuming process depending on multidisciplinary methods to create safe and effective medicines. Although considerable progress has been made by high-throughput screening methods in drug design, the cost of developing contemporary approved drugs did not match that in the past decade. The major reason is the late-stage clinical failures in Phases II and III because of the complicated interactions between drug-specific, human body and environmental aspects affecting the safety and efficacy of a drug. There is a growing hope that systems-level consideration may provide a new perspective to overcome such current difficulties of drug discovery and development. The systems pharmacology method emerged as a holistic approach and has attracted more and more attention recently. The applications of systems pharmacology not only provide the pharmacodynamic evaluation and target identification of drug molecules, but also give a systems-level of understanding the interaction mechanism between drugs and complex disease. Therefore, the present review is an attempt to introduce how holistic systems pharmacology that integrated in silico ADME/T (i.e., absorption, distribution, metabolism, excretion and toxicity), target fishing and network pharmacology facilitates the discovery of small molecular drugs at the system level.

  19. Clinical pharmacology | Blockman | Continuing Medical Education

    African Journals Online (AJOL)

    Continuing Medical Education. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 28, No 3 (2010) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register. Clinical pharmacology. M Blockman. Abstract. No Abstract ...

  20. Phytochemistry and pharmacologic properties of Myristica fragrans ...

    African Journals Online (AJOL)

    Myristica fragrans is known as “nutmeg”, its extracts and essential oil are important in drug development with numerous pharmacological activities in South Africa, India and other tropical countries. For a long time, M. fragrans has been used in traditional medicines as a carminative, stimulant, narcotic, emmenagogue and ...

  1. Jatropha Tanjorensis - Review of Phytochemistry, Pharmacology ...

    African Journals Online (AJOL)

    Based on the findings of this work, future study on the phytochemistry and chemical constituents in relation to certain other biological activities are required to fully understand the phytochemical and complex pharmacological effect of the plant specie. Further work to isolate active compounds from the plant is also necessary.

  2. Practice Points: Pharmacological therapy of female urinary ...

    African Journals Online (AJOL)

    ... selectively modulate the electrophysiological properties and the intracellular pathways of the smooth muscles of the lower urinary tract in women as therapeutic agents for UI is awaited with interest. Key words: Drugs, pharmacology, urinary incontinence, women. African Journal of Health Sciences Vol.5(1) 2005: 79-85 ...

  3. Pharmacological Properties of Nanometals (Silver, Copper, Iron)

    OpenAIRE

    Chekman, I.S.

    2015-01-01

    The article summarizes the results of studies on the pharmacological, toxicological and specific properties of nanometals (silver, iron, copper). It is established that nanoparticles of silver, copper, iron exhibit antimicrobial action. Acute toxicity of nanometals depends on their nature, administration route and animal sex. Effects on heart activity and hemodynamic status as well as erythrocyte osmotic fragility have dose-dependent nature.

  4. Pharmacological management of chronic obstructive pulmonary ...

    African Journals Online (AJOL)

    The main objective of treatment is to relieve daily symptoms, improve quality of life and importantly decrease the risk of future exacerbations. Current guidelines are based on grade A and B evidence. Pneumococcal and annual influenza vaccinations are encouraged. A holistic approach that augments pharmacological ...

  5. Current status and challenges of cytokine pharmacology

    Czech Academy of Sciences Publication Activity Database

    Zídek, Zdeněk; Anzenbacher, P.; Kmoníčková, Eva

    2009-01-01

    Roč. 157, č. 3 (2009), s. 342-361 ISSN 0007-1188 R&D Projects: GA ČR GA305/08/0535; GA MŠk 1M0508 Institutional research plan: CEZ:AV0Z50390512 Keywords : cytokines * immunotherapy * immunopharmacology Subject RIV: FR - Pharmacology ; Medidal Chemistry Impact factor: 5.204, year: 2009

  6. Pharmacological Activities of Hypnea musciformis | Najam | African ...

    African Journals Online (AJOL)

    In present study the level of serotonin was found to be decreased after the administration of H musciformis. The regular use of seaweeds as a diet will relieve the symptoms of anxiety because the known anxiolytics also manifest their effect by decreasing the concentration of serotonin. Key Word: pharmacological activity, ...

  7. International Journal of Herbs and Pharmacological Research

    African Journals Online (AJOL)

    International Journal of Herbs and Pharmacological Research (IJHPR) [ISSN: 2315-537X; E- ISSN: 2384-6836] is a peer reviewed journal publication of Anthonio Research Center. The Journal is intended to serve as a medium for the publication of research findings in the field of Herbal medication in developing countries ...

  8. Ethnomedicinal uses and pharmacological activities of Croton ...

    African Journals Online (AJOL)

    Methods: The literature search for information on ethnomedicinal uses and pharmacological activities of C. megalobotrys was undertaken using databases such as Web of Science, BMC, Science Direct, Elsevier, Scopus, PubMed and Scielo. Other relevant literature sources included books, book chapters, websites, theses, ...

  9. The pharmacological management of obesity | Marais | South ...

    African Journals Online (AJOL)

    ... its own advantages and disadvantages. Lifestyle changes and reduced caloric intake form the backbone of any pharmacological intervention. A myriad of therapeutic agents are available which offer the provision for individualised treatment. Keywords: anti-obesity agents, appetite, body composition, obesity, weight loss ...

  10. Pharmacological Interventions for Students with ADD.

    Science.gov (United States)

    Austin, Vance L.

    2003-01-01

    A review of the research on pharmacological interventions for students with attention deficit disorder finds that psychostimulants such as methylphenidate (Ritalin) are effective in improving focus and impulse control, but should be used in conjunction with psychosocial and behavioral interventions. Comprehensive medical screenings and guidelines…

  11. Systems Pharmacology in Small Molecular Drug Discovery

    Directory of Open Access Journals (Sweden)

    Wei Zhou

    2016-02-01

    Full Text Available Drug discovery is a risky, costly and time-consuming process depending on multidisciplinary methods to create safe and effective medicines. Although considerable progress has been made by high-throughput screening methods in drug design, the cost of developing contemporary approved drugs did not match that in the past decade. The major reason is the late-stage clinical failures in Phases II and III because of the complicated interactions between drug-specific, human body and environmental aspects affecting the safety and efficacy of a drug. There is a growing hope that systems-level consideration may provide a new perspective to overcome such current difficulties of drug discovery and development. The systems pharmacology method emerged as a holistic approach and has attracted more and more attention recently. The applications of systems pharmacology not only provide the pharmacodynamic evaluation and target identification of drug molecules, but also give a systems-level of understanding the interaction mechanism between drugs and complex disease. Therefore, the present review is an attempt to introduce how holistic systems pharmacology that integrated in silico ADME/T (i.e., absorption, distribution, metabolism, excretion and toxicity, target fishing and network pharmacology facilitates the discovery of small molecular drugs at the system level.

  12. Plant cannabinoids: a neglected pharmacological treasure trove.

    Science.gov (United States)

    Mechoulam, Raphael

    2005-12-01

    Most of the cannabinoids in Cannabis sativa L. have not been fully evaluated for their pharmacological activity. A publication in this issue presents evidence that a plant cannabinoid, Delta(9)-tetrahydrocannabivarin is a potent antagonist of anandamide, a major endogenous cannabinoid. It seems possible that many of the non-psychoactive constituents of this plant will be of biological interest.

  13. Radioreceptor assay: theory and applications to pharmacology

    International Nuclear Information System (INIS)

    Perret, G.; Simon, P.

    1984-01-01

    The aim of the first part of this work is to present the theory of the radioreceptor assay and to compare it to the other techniques of radioanalysis (radioimmunoassay, competitive protein binding assays). The technology of the radioreceptor assay is then presented and its components (preparation of the receptors, radioligand, incubation medium) are described. The analytical characteristics of the radioreceptor assay (specificity, sensitivity, reproductibility, accuracy) and the pharmacological significance of the results are discussed. The second part is devoted to the description of the radioreceptor assays of some pharmacological classes (neuroleptics, tricyclic antidepressants, benzodiazepines, β-blockers, anticholinergic drugs) and to their use in therapeutic drug monitoring. In conclusion, by their nature, radioreceptor assays are highly sensitive, reliable, precise, accurate and simple to perform. Their chief disadvantage relates to specificity, since any substance having an appreciable affinity to the receptor site will displace the specifically bound radioligand. Paradoxically in some cases, this lack of specificity may be advantageous in that it allows for the detection of not only the apparent compound but of active metabolites and endogenous receptor agonists as well and in that radioreceptors assays can be devised for a whole pharmacological class and not only for one drug as it is the case for classical physico-chemical techniques. For all these reasons future of radioreceptor assay in pharmacology appears promising [fr

  14. Conception of Pharmacological Knowledge and Needs Amongst ...

    African Journals Online (AJOL)

    olayemitoyin

    the medical pharmacology course completed an 18-question survey within 10min by marking one/more choices from .... By detecting the perception of the value of ... that you in turn produce good professionals that you become wealthy. 16 What should your lecturer use to prepare lectures? personal experience text books.

  15. Pharmacological Evaluation of the Antidiarrhoeal Activity of ...

    African Journals Online (AJOL)

    This study presents the pharmacological evaluation of the effects of intraperitoneal injection of aqueous seed extract of Aframomum melegueta (AM) on diarrhoea, intestinal fluid secretion and gastrointestinal transit time, induced by castor oil in rodents. The results of the study revealed that AM (50-200 mg/kg) produced a ...

  16. The parallel evolution of immunology and pharmacology.

    Science.gov (United States)

    Conti, A A

    2010-01-01

    Immunology is the systematic evaluation of the means through which human beings protect themselves and respond to the attack of internal and external agents, and Edward Jenner (1749-1823) and Louis Pasteur (1822-1895) are considered pioneers of this field. Jenner observed the protective effect of cowpox against smallpox and inoculated the cowpox in human beings to protect them from the often lethal smallpox. Pasteur developed in his laboratory a vaccine against rabies and elaborated methods for attenuating the virulence of pathogenic microorganisms while maintaining their immunogenicity. Pharmacology is the area of medical science dealing with drugs and their uses, and it was during the nineteenth century that it assumed its status of scientific specialty, mainly in German-speaking Europe, through the establishment of pharmacological institutes and dedicated laboratories. The discovery and the synthesis of drugs and the systematic evaluation of their activity have constituted through time a scientific field in which immunology and pharmacology have met and given origin to notable progress in the history of science. The development of chemotherapy, as well as of organ and tissue transplantation, in the twentieth century has been decisively promoted by both immunology and pharmacology. In the last three decades the relationship between these two scientific branches has become increasingly closer in basic research, clinical science, medical education and also editorial scientific activity, as documented by the Journal hosting this paper.

  17. Ethnobotanical, Phytochemical and Pharmacological Aspects of ...

    African Journals Online (AJOL)

    Daphne mucronata is a shrub well known as a medicinal plant in different regions of Asia. Ethnobotanical, phytochemical and pharmacological studies have revealed strong anti-cancer potential of the plant. Literature reports the evaluation of the initial bioactivity profile and extraction of the plant followed by different ...

  18. Ethnobotanical, phytochemical and pharmacological properties of ...

    African Journals Online (AJOL)

    Purpose: To present an overview of the ethnobotany, phytochemistry and pharmacology of Crinum bulbispermum so as to understand its importance and potential in primary healthcare systems. Methods: A review of the literature was undertaken and an in-depth analysis of previous research on ethnobotany, phytochemistry ...

  19. Phytochemical, pharmacological and biological profiles of Tragia ...

    African Journals Online (AJOL)

    Methods: The reported data/information was retrieved mainly from the online databases of PubMed (MEDLINE), EMBASE and Botanical Survey of India. Results: The present review elaborated the phytochemical, pharmacological and biological properties of the selected five Tragia species obtained from recent literature.

  20. Pharmacological therapy of chronic obstructive pulmonary disease

    African Journals Online (AJOL)

    patients with COPD require pharmacological therapy. ... pulmonary dysfunction. Clearly the patient's tolerance to the various drugs will influence the choice of long-term maintenance treatment. The other important factor in the .... blocking cervical immune responses might leave her less protected against other infections.

  1. Pharmacological interventions for alcohol relapse prevention ...

    African Journals Online (AJOL)

    Alcohol dependence is a chronic, debilitating disorder that is an important public health problem worldwide. Combined psychological and pharmacological treatment packages produce best outcomes in its management. In this paper we discuss the three NICE – approved relapse prevention medications used in treatment of ...

  2. Non-pharmacological management of COPD

    African Journals Online (AJOL)

    Practitioners often do not have time to define this problem carefully or advise patients adequately. A careful history and evaluation of patients will delineate the precise reason for dyspnoea and the appropriate management. For chronic obstructive pulmonary disease (COPD), in particular, non-pharmacological treatments ...

  3. Synthesis, Spectroscopic and Pharmacological Studies of Bivalent ...

    African Journals Online (AJOL)

    NICO

    Synthesis, Spectroscopic and Pharmacological Studies of. Bivalent Copper, Zinc and Mercury Complexes of Thiourea. Shikha Parmar*, Yatendra Kumar and Ashu Mittal. I.T.S Paramedical College (Pharmacy), Delhi Meerut Road, Muradnagar, Ghaziabad 201206, India. Received 4 June 2010, revised 14 June 2010, ...

  4. Uranium resources and requirements

    International Nuclear Information System (INIS)

    Silver, J.M.; Wright, W.J.

    1976-01-01

    Australia has about 19% of the reasonably assured resources of uranium in the Western World recoverable at costs of less than $A20/kgU, or about 9% of the resources (reasonably assured and estimated additional) recoverable at costs of less than $A30/kgU. Australia's potential for further discoveries of uranium is good. Nevertheless, if Australia did not export any of these resources it would probably have only a marginal effect on the development of nuclear power. Other resources would be exploited earlier and prices would rise, but not sufficiently to make the costs of nuclear power unattractive. On the other hand, this policy could deny to Australia real benefits in foreign earnings, employment and national development. (author)

  5. Uranium resources and requirements

    International Nuclear Information System (INIS)

    Silver, J.M.; Wright, W.J.

    1975-08-01

    Australia has about 19% of the reasonably assured resources of uranium in the Western World recoverable at costs of less than $A20 per kilogram, or about 9% of the resources (reasonably assured and estimated additional) recoverable at costs of less than $A30 per kilogram. Australia's potential for further discoveries of uranium is good. Nevertheless, if Australia did not export any of these resources it would probably have only a marginal effect on the development of nuclear power; other resources would be exploited earlier and prices would rise, but not sufficiently to make the costs of nuclear power unattractive. On the other hand, this policy could deny to Australia real benefits in foreign currency earnings, employment and national development. (author)

  6. The mass action equation in pharmacology.

    Science.gov (United States)

    Kenakin, Terry

    2016-01-01

    The mass action equation is the building block from which all models of drug-receptor interaction are built. In the simplest case, the equation predicts a sigmoidal relationship between the amount of drug-receptor complex and the logarithm of the concentration of drug. The form of this function is also the same as most dose-response relationships in pharmacology (such as enzyme inhibition and the protein binding of drugs) but the potency term in dose-response relationships very often differs in meaning from the similar term in the simple mass action relationship. This is because (i) most pharmacological systems are collections of mass action reactions in series and/or in parallel and (ii) the important assumptions in the mass action reaction are violated in complex pharmacological systems. In some systems, the affinity of the receptor R for some ligand A is modified by interaction of the receptor with the allosteric ligand B and concomitantly the affinity of the receptor for ligand B is modified to the same degree. When this occurs, the observed affinity of the ligand A for the receptor will depend on both the concentration of the co-binding allosteric ligand and its nature. The relationships between drug potency in pharmacological models and the equilibrium dissociation constants defined in single mass action reactions are discussed. More detailed knowledge of efficacy has led to new models of drug action that depend on the relative probabilities of different states, and these have taken knowledge of drug-receptor interactions beyond Guldberg and Waage. © 2015 The British Pharmacological Society.

  7. Pharmacology and function of melatonin receptors

    International Nuclear Information System (INIS)

    Dubocovich, M.L.

    1988-01-01

    The hormone melatonin is secreted primarily from the pineal gland, with highest levels occurring during the dark period of a circadian cycle. This hormone, through an action in the brain, appears to be involved in the regulation of various neural and endocrine processes that are cued by the daily change in photoperiod. This article reviews the pharmacological characteristics and function of melatonin receptors in the central nervous system, and the role of melatonin in mediating physiological functions in mammals. Melatonin and melatonin agonists, at picomolar concentrations, inhibit the release of dopamine from retina through activation of a site that is pharmacologically different from a serotonin receptor. These inhibitory effects are antagonized by the novel melatonin receptor antagonist luzindole (N-0774), which suggests that melatonin activates a presynaptic melatonin receptor. In chicken and rabbit retina, the pharmacological characteristics of the presynaptic melatonin receptor and the site labeled by 2-[125I]iodomelatonin are identical. It is proposed that 2-[125I]iodomelatonin binding sites (e.g., chicken brain) that possess the pharmacological characteristics of the retinal melatonin receptor site (order of affinities: 2-iodomelatonin greater than 6-chloromelatonin greater than or equal to melatonin greater than or equal to 6,7-di-chloro-2-methylmelatonin greater than 6-hydroxymelatonin greater than or equal to 6-methoxymelatonin greater than N-acetyltryptamine greater than or equal to luzindole greater than N-acetyl-5-hydroxytryptamine greater than 5-methoxytryptamine much greater than 5-hydroxytryptamine) be classified as ML-1 (melatonin 1). The 2-[125I]iodomelatonin binding site of hamster brain membranes possesses different binding and pharmacological characteristics from the retinal melatonin receptor site and should be classified as ML-2. 64 references

  8. SLA-aware Resource Management

    Science.gov (United States)

    Sun, Yih Leong; Perrott, Ron; Harmer, Terence J.; Cunningham, Christina; Wright, Peter; Kennedy, John; Edmonds, Andy; Bayon, Victor; Maza, Jacek; Berginc, Gregor; Hadalin, Primož

    The management of infrastructure resources in a large-scale environment such as Grid Computing is a challenging task and places significant demands on resource discovery, scheduling and the underlying communication channels. The fulfillment of the business goals and service quality in such an environment requires an infrastructure to cope with changes in demand and infrastructure performance. In this paper, we propose an abstract service-oriented framework for SLA-aware dynamic resource management. The framework provides selfmanaging, self-configuration and self-healing strategies in order to support autonomic and ambient service management. We study an SLA negotiation process at the infrastructure resource layer, live migration for resource re-provisioning, a multi-layer architecture framework to monitor infrastructure resources and a harmonized interface to access arbitrary sources of infrastructure resources based on SLA requirements. Resource usage will be optimized according to the provider policies and SLA requirements.

  9. Publication trends in Naunyn-Schmiedeberg's Archives of Pharmacology: focus on pharmacology in Egypt.

    Science.gov (United States)

    El-Mas, Mahmoud M; El-Gowelli, Hanan M; Michel, Martin C

    2013-11-01

    In a previous analysis of the country of origin of papers published in Naunyn-Schmiedeberg's Archives of Pharmacology, a major shift toward contributions from emerging market countries, was noticed in comparison of 2010 to 2001 publications. Repeating such analysis for 2012 publications in the journal confirmed this trend. An interesting new trend was the emerging presence of papers from a variety of Islamic countries including Egypt. Based on this trend, we shortly review the history and current structure of pharmacology in Egypt. It appears that the presence of Egyptian pharmacology in international journals including pharmacology journals has sharply been increasing over the last two decades. Challenges for a continuation of this encouraging trend are being discussed.

  10. PUBLIC POLICY AND TAXATION

    Directory of Open Access Journals (Sweden)

    IOSIF MOLDOVAN

    2014-10-01

    Full Text Available The state administration process and hence also the economy coordination effort requires the promotion of robust, consistent and transparent public policy, which must be accepted by all stakeholders of economic development. Public policy is a set of measures taken by the authorities legally constituted as public power. Under normal conditions these policy aims at improving living conditions of citizens by developing grounded strategies which are applied by measures implemented to stimulate economic development in all its complexity by harmonizing the efforts of the institutional and non-institutional bodies responsible for ensuring the overall public interest. In Romania, public policies, especially fiscal ones on which we dwell, not reached in many cases the expected effects primarily because of their superficial grounding, lack of transparency, unpredictability, poor communication and secondly as an effect of ineffective management of public financial resources.

  11. Pharmacological and non-pharmacological interventions to influence adipose tissue function

    OpenAIRE

    Westerink, Jan; Visseren, Frank LJ

    2011-01-01

    Abstract Obesity is associated with metabolic derangements such as insulin resistance, inflammation and hypercoagulobility which can all be understood as consequences of adipose tissue dysfunction. The potential role for adipose tissue derived cytokines and adipokines in the development of vascular disease and diabetes may produce a clinical need to influence adipose tissue function. Various pharmacological and non-pharmacological interventions affect plasma cytokine and adipokine levels. The...

  12. Pharmacological and non-pharmacological interventions to influence adipose tissue function

    Directory of Open Access Journals (Sweden)

    Visseren Frank LJ

    2011-01-01

    Full Text Available Abstract Obesity is associated with metabolic derangements such as insulin resistance, inflammation and hypercoagulobility which can all be understood as consequences of adipose tissue dysfunction. The potential role for adipose tissue derived cytokines and adipokines in the development of vascular disease and diabetes may produce a clinical need to influence adipose tissue function. Various pharmacological and non-pharmacological interventions affect plasma cytokine and adipokine levels. The effects of these interventions depend on weight loss per se, changes in fat distribution without weight loss and/or direct effects on adipose tissue inflammation. Weight loss, as a result of diet, pharmacology and surgery, positively influences plasma adipokines and systemic inflammation. Several classes of drugs influence systemic inflammation directly through their anti-inflammatory actions. PPAR-γ agonism positively influences adipose tissue inflammation in several classes of intervention such as the thiazolidinediones and perhaps salicylates, CB1-antagonists and angiotensin II receptor blockers. Furthermore, within drug classes there are differential effects of individual pharmacologic agents on adipose tissue function. It can be concluded that several commonly used pharmacological and non-pharmacological interventions have unintended influences on adipose tissue function. Improving adipose tissue function may contribute to reducing the risk of vascular diseases and the development of type 2 diabetes.

  13. Competing For industry Resources

    International Nuclear Information System (INIS)

    Arnstad, Marit

    1998-01-01

    This presentation by Norway's Minister of Petroleum and Energy describes (1) Norway in the energy picture, (2) oil market developments, (3) the establishment of an energy policy and (4) the investment level of the Norwegian petroleum activities. Value creation from Norwegian petroleum resources is directly connected with the commercial companies' participation in the activities. Thus, it has been a main challenge for Norway to establish a balanced petroleum policy and a legal framework. Presumably Norway will remain a prospective and attractive petroleum province for a long time. Over the years, Norway has developed three very competent and competitive national oil companies and a significant national supply industry. This industry is highly competitive internationally. Many new petroleum provinces are opening up for foreign investors and energy consumption of the world is expected to increase significantly the next 20 - 30 years. This implies increased demand for the products, but also strong competition for industry resources

  14. The policies

    International Nuclear Information System (INIS)

    Laruelle, Ph.; Snegaroff, Th.; Moreau, S.; Tellenne, C.; Brunel, S.

    2005-01-01

    Fourth chapter of the book on the geo-policy of the sustainable development, this chapter deal with the different and international policies concerned by the problem. The authors analyze the american energy attitude and policy, the economical equilibrium facing the environmental equilibrium for the european policy, the sanctified and sacrificed nature and the japanese attitude, India and China, the great fear of the 21 century and the sustainable development in Africa. (A.L.B.)

  15. Pharmacists' and general practitioners' pharmacology knowledge and pharmacotherapy skills

    NARCIS (Netherlands)

    Keijsers, Carolina J P W; Leendertse, Anne J; Faber, Adrianne; Brouwers, Jacobus R B J; de Wildt, Dick J; Jansen, Paul A F

    Understanding differences in the pharmacology knowledge and pharmacotherapy skills of pharmacists and physicians is vital to optimizing interprofessional collaboration and education. This study investigated these differences and the potential influence of work experience. The pharmacology knowledge

  16. Assessment of rural energy resources

    International Nuclear Information System (INIS)

    Rijal, K.; Bansal, N.K.; Grover, P.D.

    1990-01-01

    This article presents the methodological guidelines used to assess rural energy resources with an example of its application in three villages each from different physiographic zones of Nepal. Existing energy demand patterns of villages are compared with estimated resource availability, and rural energy planning issues are discussed. Economics and financial supply price of primary energy resources are compared, which provides insight into defective energy planning and policy formulation and implication in the context of rural areas of Nepal. Though aware of the formidable consequences, the rural populace continues to exhaust the forest as they are unable to find financially cheaper alternatives. Appropriate policy measures need to be devised by the government to promote the use of economically cost-effective renewable energy resources so as to change the present energy usage pattern to diminish the environmental impact caused by over exploitation of forest resources beyond their regenerative capacity

  17. Clinical pharmacology considerations in biologics development

    Science.gov (United States)

    Zhao, Liang; Ren, Tian-hua; Wang, Diane D

    2012-01-01

    Biologics, including monoclonal antibodies (mAbs) and other therapeutic proteins such as cytokines and growth hormones, have unique characteristics compared to small molecules. This paper starts from an overview of the pharmacokinetics (PK) of biologics from a mechanistic perspective, the determination of a starting dose for first-in-human (FIH) studies, and dosing regimen optimisation for phase II/III clinical trials. Subsequently, typical clinical pharmacology issues along the corresponding pathways for biologics development are summarised, including drug-drug interactions, QTc prolongation, immunogenicity, and studies in specific populations. The relationships between the molecular structure of biologics, their pharmacokinetic and pharmacodynamic characteristics, and the corresponding clinical pharmacology strategies are summarised and depicted in a schematic diagram. PMID:23001474

  18. [Pharmacological therapeutic intervention in mild cognitive impairment].

    Science.gov (United States)

    Arriola Manchola, Enrique; Alaba Loinaz, Javier

    2017-06-01

    Mild cognitive impairment (MCI) is a syndrome encompassing affective and behavioural symptoms and various subtypes. MCI is a heterogeneous clinical entity with varied causes (degenerative, vascular, psychiatric, non-neurological disorders), and there is wide variation in symptoms and clinical course. There are multiple causes and consequently various treatments can be applied and should be combined with non-pharmacological measures. This article describes both preventive and therapeutic pharmacological interventions: control of vascular risk factors, avoidance of iatrogeny, use of nutraceuticals, CDP-choline, and Ginkgo biloba EGb 761 ® , and improvement in sense organs. Copyright © 2017 Sociedad Española de Geriatría y Gerontología. Publicado por Elsevier España, S.L.U. All rights reserved.

  19. Clinical pharmacology considerations in biologics development.

    Science.gov (United States)

    Zhao, Liang; Ren, Tian-hua; Wang, Diane D

    2012-11-01

    Biologics, including monoclonal antibodies (mAbs) and other therapeutic proteins such as cytokines and growth hormones, have unique characteristics compared to small molecules. This paper starts from an overview of the pharmacokinetics (PK) of biologics from a mechanistic perspective, the determination of a starting dose for first-in-human (FIH) studies, and dosing regimen optimisation for phase II/III clinical trials. Subsequently, typical clinical pharmacology issues along the corresponding pathways for biologics development are summarised, including drug-drug interactions, QTc prolongation, immunogenicity, and studies in specific populations. The relationships between the molecular structure of biologics, their pharmacokinetic and pharmacodynamic characteristics, and the corresponding clinical pharmacology strategies are summarised and depicted in a schematic diagram.

  20. Pharmacological caspase inhibitors: research towards therapeutic perspectives.

    Science.gov (United States)

    Kudelova, J; Fleischmannova, J; Adamova, E; Matalova, E

    2015-08-01

    Caspases are key molecules of apoptosis and the inflammatory response. Up-regulation of the caspase cascade contributes to human pathologies such as neurodegenerative and immune disorders. Thus, blocking the excessive apoptosis by pharmacological inhibitors seems promising for therapeutic interventions in such diseases. Caspase inhibitors, both natural and artificial, have been used as research tools and have helped to define the role of the individual caspases in apoptosis and in non-apoptotic processes. Moreover, some caspase inhibitors have demonstrated their therapeutic efficiency in the reduction of cell death and inflammation in animal models of human diseases. However, no drug based on caspase inhibition has been approved on the market until now. Thus, the development of therapeutic approaches that specifically target caspases remains a great challenge and is now the focus of intense biological and clinical interest. Here, we provide a brief review of recent knowledge about pharmacological caspase inhibitors with special focus on their proposed clinical applications.

  1. The Chemistry and Pharmacology of Citrus Limonoids.

    Science.gov (United States)

    Gualdani, Roberta; Cavalluzzi, Maria Maddalena; Lentini, Giovanni; Habtemariam, Solomon

    2016-11-13

    Citrus limonoids (CLs) are a group of highly oxygenated terpenoid secondary metabolites found mostly in the seeds, fruits and peel tissues of citrus fruits such as lemons, limes, oranges, pumellos, grapefruits, bergamots, and mandarins. Represented by limonin, the aglycones and glycosides of CLs have shown to display numerous pharmacological activities including anticancer, antimicrobial, antioxidant, antidiabetic and insecticidal among others. In this review, the chemistry and pharmacology of CLs are systematically scrutinised through the use of medicinal chemistry tools and structure-activity relationship approach. Synthetic derivatives and other structurally-related limonoids from other sources are include in the analysis. With the focus on literature in the past decade, the chemical classification of CLs, their physico-chemical properties as drugs, their biosynthesis and enzymatic modifications, possible ways of enhancing their biological activities through structural modifications, their ligand efficiency metrics and systematic graphical radar plot analysis to assess their developability as drugs are among those discussed in detail.

  2. Pharmacological management of cystic fibrosis related diabetes.

    Science.gov (United States)

    Moheet, Amir; Moran, Antoinette

    2018-02-01

    There are limited data from randomized clinical trials to guide optimal options for pharmacological treatment of cystic fibrosis related diabetes (CFRD). Current guidelines recommend insulin as the only treatment option for CFRD. Areas covered: Current guidelines for screening, diagnosis and pharmacological agents for treatment of impaired glucose tolerance and CFRD in patients with cystic fibrosis are reviewed. Insights from clinical studies examining the role of insulin therapy in CFRD are presented. Expert commentary: CFRD is the most common extra pulmonary complication of cystic fibrosis, and is primarily related to insulin insufficiency. Insulin is the treatment of choice for CFRD. Insulin treatment is associated with improvement in glycemic control, nutritional status and lung function. Current data does not support use of oral hypoglycemic agents for treatment of CFRD.

  3. Ethnobotany, phytochemistry and pharmacology of Uncaria (Rubiaceae).

    Science.gov (United States)

    Heitzman, Mary E; Neto, Catherine C; Winiarz, Elizabeth; Vaisberg, Abraham J; Hammond, Gerald B

    2005-01-01

    The Uncaria genus is an important source of medicinal natural products, particularly alkaloids and triterpenes. The collected information is an attempt to cover the more recent developments in the ethnobotany, pharmacology and phytochemistry of this genus. During the past 20 years, alkaloids, terpenes, quinovic acid glycosides, flavonoids and coumarins have been isolated from Uncaria. Fifty-three novel structures are reported in this review. The species in which the largest number of compounds has been identified is the Peruvian Uncaria tomentosa or 'cat's claw.' Pharmacological studies are described according to cytotoxicity, anti-inflammatory, antiviral, immunostimulation, antioxidant, CNS-related response, vascular, hypotensive, mutagenicity and antibacterial properties. The potential for development of leads from Uncaria continues to grow, particularly in the area of immunomodulatory, anti-inflammatory and vascular-related conditions. The information summarized here is intended to serve as a reference tool to practitioners in the fields of ethnopharmacology and natural products chemistry.

  4. Pharmacological evaluation of bee venom and melittin

    Directory of Open Access Journals (Sweden)

    Camila G. Dantas

    Full Text Available The objective of this study was to identify the pharmacological effects of bee venom and its major component, melittin, on the nervous system of mice. For the pharmacological analysis, mice were treated once with saline, 0.1 or 1.2 mg/kg of bee venom and 0.1 mg/kg of melittin, subcutaneously, 30 min before being submitted to behavioral tests: locomotor activity and grooming (open-field, catalepsy, anxiety (elevated plus-maze, depression (forced swimming test and apomorphine-induced stereotypy. Haloperidol, imipramine and diazepam were administered alone (positive control or as a pre-treatment (haloperidol.The bee venom reduced motor activity and promoted cataleptic effect, in a similar manner to haloperidol.These effects were decreased by the pretreatment with haloperidol. Both melittin and bee venom decreased the apomorphine-induced stereotypies. The data indicated the antipsychotic activity of bee venom and melittin in a murine model.

  5. Spectroscopic properties of pharmacologically active phenols

    Science.gov (United States)

    Tolstorozhev, G. B.; Skornyakov, I. V.; Bel'kov, M. V.; Shadyro, O. I.; Polozov, G. I.; Sorokin, V. L.; Ksendzova, G. A.

    2012-05-01

    The IR Fourier-transform spectra of pharmacologically active phenol molecules in solutions in CCl4 and in the crystalline state have been studied. Phenol derivatives with different directivities and different levels of pharmacological efficiency have been examined. Based on analysis of the IR spectra of screened phenols, the antimicrobial activity of phenols with free hydroxyl groups has been shown to be highest. The high antimicrobial activity of aminophenols is related to the formation of intramolecular hydrogen bonds. For aminophenols that are active against herpesviruses, O-H...N hydrogen bonds are formed in molecules. The main characteristic of the high antiviral activity against A-type influenza is predominance of intramolecular hydrogen bonds of the O-H...O=C type in molecules. Sulfur-containing aminophenols, which manifest activity against HIV infection, are characterized by the occurrence of hydrogen bonds that involve the participation of the OH, NH, and SO2 groups.

  6. Common mullein, pharmacological and chemical aspects

    Directory of Open Access Journals (Sweden)

    Muhammad Riaz

    Full Text Available Verbascum thapsus L. [Khardhag or Common mullein], a member of the family Scrophulariaceae, is a famous herb that is found all over Europe, in temperate Asia, in North America and is well-reputed due to its medicinal properties. This medicinal herb contains various chemical constituents like saponins, iridoid and phenylethanoid glycosides, flavonoids, vitamin C and minerals. It is famous in various communities worldwide for the treatment of various disorders of both humans and animals aliments. A number of pharmacological activities such as anti-inflammatory, antioxidant, anticancer, antimicrobial, antiviral, antihepatotoxic and anti-hyperlipidemic activity have been ascribed to this plant. The plant is used to treat tuberculosis also, earache and bronchitis. In the present paper botanical and ethnomedicinal description, pharmacological profile and phytochemistry of this herb is being discussed.

  7. [Pharmaconutrition: pharmacological approach to nutrition therapy].

    Science.gov (United States)

    Télessy, István

    2014-12-21

    Reviewing the literature of nutrition therapy one can conclude that during the last decade the pharmacological action of several nutrients has been demonstrated. However, research activity is still at the beginning and it could be verified in a restricted number of nutrients only that in which conditions (illnesses), dose and duration we can expect therapeutic effect in addition to nutrition. The examples of glutamine, arginine, taurine, leucine, ω-3 fatty acids, however, support the possibility that complex reactions and treatment results observed in certain patients are not purely due to nutritional support but the consequence of additional pharmacological action as well. Evaluation of results of therapeutic intervention is especially difficult because in the everyday practice physicians try to use several therapeutic modalities that can be beneficial for the patient. Therefore, retrospective separation of beneficial components of the therapeutic agents is almost impossible. Only well designed, randomized and multicentric studies can verify specific therapeutic action of certain ingredients ie. nutrients.

  8. Pharmacological treatment for infectious corneal ulcers.

    Science.gov (United States)

    Miller, Darlene

    2013-04-01

    Cornea ulceration and infectious keratitis are leading causes of corneal morbidity and blindness. Infectious causes are among the most frequent and most severe. Management strategies for bacterial corneal ulcers have changed significantly over the last decades, however with a more limited progress in the treatment and management of nonbacterial, infectious ulcers. This paper provides an overview of the current principles, strategies and treatment choices for infectious corneal ulcers in adults. Topical application with a broad-spectrum antimicrobial remains the preferred method for the pharmacological management of infectious corneal ulcers. Increasing reports of clinical failures and in vitro resistance to antibiotics to treat the most common infectious (bacterial) corneal ulcers are increasing concerns. New approaches for improvement in the pharmacological management of corneal ulcers should focus on strategies for a more rational and evidence-based use of current antimicrobials and development of products to modulate the host immune response and to neutralize microbial toxins and other immune modulators.

  9. Argemone mexicana: chemical and pharmacological aspects

    Directory of Open Access Journals (Sweden)

    Goutam Brahmachari

    2013-03-01

    Full Text Available The Papaveraceae, informally known as the poppy family, are an ethnopharmacologically important family of 44 genera and approximately 760 species of flowering plants. The present work offers a review addressing the detailed chemistry and pharmacology of Argemone mexicana L. regarded as one of the most significant plant species in traditional system of medicine. The plant is used in different parts of the world for the treatment of several ailments including tumors, warts, skin diseases, inflammations, rheumatism, jaundice, leprosy, microbial infections, and malaria. Interestingly, the plant is the source of a diverse kind of chemical constituents although alkaloids are mostly abundant. Beyond pharmaceutical efficacies, certain plant parts also show toxic effects as well. Hence, an up-to-date information on the chemical and pharmacological knowledge on this plant may be helpful to guide researchers anticipating to undertake further investigations in these directions. The present review covers literature up to 2012 and enlists 111 references.

  10. World Antimalarial Resistance Network (WARN IV: Clinical pharmacology

    Directory of Open Access Journals (Sweden)

    Gbotosho Grace O

    2007-09-01

    Full Text Available Abstract A World Antimalarial Resistance Network (WARN database has the potential to improve the treatment of malaria, through informing current drug selection and use and providing a prompt warning of when treatment policies need changing. This manuscript outlines the contribution and structure of the clinical pharmacology component of this database. The determinants of treatment response are multi-factorial, but clearly providing adequate blood concentrations is pivotal to curing malaria. The ability of available antimalarial pharmacokinetic data to inform optimal dosing is constrained by the small number of patients studied, with even fewer (if any studies conducted in the most vulnerable populations. There are even less data relating blood concentration data to the therapeutic response (pharmacodynamics. By pooling all available pharmacokinetic data, while paying careful attention to the analytical methodologies used, the limitations of small (and thus underpowered individual studies may be overcome and factors that contribute to inter-individual variability in pharmacokinetic parameters defined. Key variables for pharmacokinetic studies are defined in terms of patient (or study subject characteristics, the formulation and route of administration of the antimalarial studied, the sampling and assay methodology, and the approach taken to data analysis. Better defining these information needs and criteria of acceptability of pharmacokinetic-pharmacodynamic (PK-PD studies should contribute to improving the quantity, relevance and quality of these studies. A better understanding of the pharmacokinetic properties of antimalarials and a more clear definition of what constitutes "therapeutic drug levels" would allow more precise use of the term "antimalarial resistance", as it would indicate when treatment failure is not caused by intrinsic parasite resistance but is instead the result of inadequate drug levels. The clinical pharmacology component

  11. Pharmacological Properties of Nanometals (Silver, Copper, Iron

    Directory of Open Access Journals (Sweden)

    Chekman, I.S.

    2015-01-01

    Full Text Available The article summarizes the results of studies on the pharmacological, toxicological and specific properties of nanometals (silver, iron, copper. It is established that nanoparticles of silver, copper, iron exhibit antimicrobial action. Acute toxicity of nanometals depends on their nature, administration route and animal sex. Effects on heart activity and hemodynamic status as well as erythrocyte osmotic fragility have dose-dependent nature.

  12. Pharmacologic and clinical assessment of kratom.

    Science.gov (United States)

    White, C Michael

    2018-03-01

    This article reviews the pharmacology, clinical utility, adverse effects, and abuse potential of kratom. The leaves of Mitragyna speciosa contain the biologically active alkaloids of kratom. Kratom exerts opioid and α-2 receptor agonistic effects as well as antiinflammatory and parasympathetic-impeding effects. There are no published human pharmacologic, pharmacokinetic, or drug interaction studies on kratom or mitragynine, making it virtually impossible to fully understand kratom's therapeutic potential and risks and the populations most likely to benefit or experience harm from its use. Kratom has been used to ameliorate opioid withdrawal symptoms but also induces withdrawal. Human pharmacologic, pharmacokinetic, and clinical data are of low quality, precluding any firm conclusions regarding safety and efficacy. Respiratory depression has not been commonly reported, but kratom does cause a host of adverse effects without clear guidance for how they should be treated. There are numerous assessments where people have been unable to stop using kratom therapy, and withdrawal signs and symptoms are problematic. Kratom does not appear in normal drug screens and, when taken with other substances of abuse, may not be recognized. Thirty-six deaths have been attributed to kratom, and the Food and Drug Administration issued a public health warning about the substance in November 2017. Kratom exerts opioid and α-2 receptor agonistic effects as well as antiinflammatory and parasympathetic-impeding effects. Human pharmacologic, pharmacokinetic, and clinical data are of low quality, precluding any firm conclusions regarding safety and efficacy. Copyright © 2018 by the American Society of Health-System Pharmacists, Inc. All rights reserved.

  13. Conception of pharmacological knowledge and needs amongst ...

    African Journals Online (AJOL)

    Students who are taking/have taken the medical pharmacology course completed an 18-question survey within 10min by marking one/more choices from ... and 31.1% different drugs in a group; 45.8% prefer to study lecturers' notes, 26.7% textbooks, 9.8% the Internet, and 2.7% journals; 46.7% use standard textbooks, ...

  14. Editorial. Themed issue of the British Journal of Pharmacology.

    Science.gov (United States)

    Summers, R J

    2014-03-01

    This themed issue of the British Journal of Pharmacology stems from the 7th in the series of meetings on the Molecular Pharmacology of G Protein-Coupled Receptors (MPGPCR) held at the Monash Institute of Pharmaceutical Sciences in Melbourne Australia from the 6th-8th December 2012. © 2014 The British Pharmacological Society.

  15. The role of policy for documentary systems

    Directory of Open Access Journals (Sweden)

    Maria Mata Caravaca

    2015-05-01

    Full Text Available The article analyzes the role that policies have in guaranteeing the quality of creation, management and maintenance of digital resources, and offers an overview of national and international policies and standards that refer to records management and digital preservation. Finally, the article illustrates ICCROM’s records management manual and its digital preservation policy and strategy.

  16. Anticipating drug side effects by comparative pharmacology.

    Science.gov (United States)

    Garcia-Serna, Ricard; Mestres, Jordi

    2010-10-01

    Anticipating the likely side effect profile of drugs is an aspect of key importance in current drug discovery, development and marketing. It was recently shown that drug pairs having similar side effect profiles had also affinity for a common target. Acknowledging that most drugs have a rich polypharmacology, we provide proof that drugs related by side effect similarity have in fact affinities for multiple common targets beyond their primary targets and set the basis for the use of comparative pharmacology to anticipate drug side effects. Nomenclature issues to be able to identify and properly store drugs, targets and side effects from multiple public sources; the construction of drug networks from side effect similarity and the inference of common targets among them; polypharmacology and data completeness; methods for in silico target profiling; and comparative pharmacology and inference of common side effects. The reader is provided with a detailed step-by-step analysis of the entire process from predicting the target profile of a compound to anticipating its side effect profile, and a discussion on the particular needs and limitations found at each stage of the process through illustrative examples. Comparing preclinical pharmacology data obtained in vitro but also predicted in silico using modern virtual screening methods represents an attractive strategy to anticipate clinical drug side effects.

  17. Pharmacological characterization of tachykinin tetrabranched derivatives.

    Science.gov (United States)

    Ruzza, Chiara; Rizzi, Anna; Malfacini, Davide; Cerlesi, Maria Camilla; Ferrari, Federica; Marzola, Erika; Ambrosio, Caterina; Gro, Cristina; Severo, Salvadori; Costa, Tommaso; Calo, Girolamo; Guerrini, Remo

    2014-09-01

    Peptide welding technology (PWT) is a novel chemical strategy that allows the synthesis of multibranched peptides with high yield, purity and reproducibility. Using this technique, we have synthesized and pharmacologically characterized the tetrabranched derivatives of the tachykinins, substance P (SP), neurokinin A (NKA) and B (NKB). The following in vitro assays were used: calcium mobilization in cells expressing human recombinant NK receptors, BRET studies of G-protein - NK1 receptor interaction, guinea pig ileum and rat urinary bladder bioassays. Nociceptive behavioural response experiments were performed in mice following intrathecal injection of PWT2-SP. In calcium mobilization studies, PWT tachykinin derivatives behaved as full agonists at NK receptors with a selectivity profile similar to that of the natural peptides. NK receptor antagonists display similar potency values when tested against PWT2 derivatives and natural peptides. In BRET and bioassay experiments PWT2-SP mimicked the effects of SP with similar potency, maximal effects and sensitivity to aprepitant. After intrathecal administration in mice, PWT2-SP mimicked the nociceptive effects of SP, but with higher potency and a longer-lasting action. Aprepitant counteracted the effects of PWT2-SP in vivo. The present study has shown that the PWT technology can be successfully applied to the peptide sequence of tachykinins to generate tetrabranched derivatives characterized with a pharmacological profile similar to the native peptides. In vivo, PWT2-SP displayed higher potency and a marked prolongation of action, compared with SP. © 2014 The British Pharmacological Society.

  18. Pharmacological Management of Esophageal Food Bolus Impaction

    Directory of Open Access Journals (Sweden)

    Yasir Mohammed Khayyat

    2013-01-01

    Full Text Available Background. Soft esophageal bolus impaction is an emergency that requires skilled endoscopic removal if persistent obstructive symptoms do not resolve spontaneously after careful observation. Expedited care of these patients is crucial to avoid respiratory and mechanical complications. Other possible options for management include medical agents used to manage it prior to performing endoscopy if access to endoscopy was not available or declined by the patient. Aim. To review the available pharmacological and other nonmedicinal options and their mechanism of relief for soft esophageal impaction. Method. Pubmed, Medline and Ovid were used for search of MESH terms pertinent including “foreign body, esophageal, esophageal bolus and medical” for pharmacological and non medicinial agents used for management of esophageal soft bolus impaction as well as manual review of the cross-references. Results. Several agents were identified including Buscopan, Glucagon, nitrates, calcium channel blockers, and papaveretum. Non medicinal agents are water, effervescent agents, and papain. No evidence was found to suggest preference or effectiveness of use of a certain pharmacological agent compared to others. Buscopan, Glucagon, benzodiazepines, and nitrates were studied extensively and may be used in selected patients with caution. Use of papain is obsolete in management of soft bolus impaction.

  19. Phage Therapy: Eco-Physiological Pharmacology

    Directory of Open Access Journals (Sweden)

    Stephen T. Abedon

    2014-01-01

    Full Text Available Bacterial virus use as antibacterial agents, in the guise of what is commonly known as phage therapy, is an inherently physiological, ecological, and also pharmacological process. Physiologically we can consider metabolic properties of phage infections of bacteria and variation in those properties as a function of preexisting bacterial states. In addition, there are patient responses to pathogenesis, patient responses to phage infections of pathogens, and also patient responses to phage virions alone. Ecologically, we can consider phage propagation, densities, distribution (within bodies, impact on body-associated microbiota (as ecological communities, and modification of the functioning of body “ecosystems” more generally. These ecological and physiological components in many ways represent different perspectives on otherwise equivalent phenomena. Comparable to drugs, one also can view phages during phage therapy in pharmacological terms. The relatively unique status of phages within the context of phage therapy as essentially replicating antimicrobials can therefore result in a confluence of perspectives, many of which can be useful towards gaining a better mechanistic appreciation of phage therapy, as I consider here. Pharmacology more generally may be viewed as a discipline that lies at an interface between organism-associated phenomena, as considered by physiology, and environmental interactions as considered by ecology.

  20. Pharmacological Effects of Biotin in Animals.

    Science.gov (United States)

    Riveron-Negrete, Leticia; Fernandez-Mejia, Cristina

    2017-01-01

    In recent decades, it was found that vitamins affect biological functions in ways other than their long-known functions; niacin is the best example of a water-soluble vitamin known to possess multiple actions. Biotin, also known as vitamin B7 or vitamin H, is a water-soluble B-complex vitamin that serves as a covalently-bound coenzyme of carboxylases. It is now well documented that biotin has actions other than participating in classical enzyme catalysis reactions. Several lines of evidence have demonstrated that pharmacological concentrations of biotin affect glucose and lipid metabolism, hypertension, reproduction, development, and immunity. The effect of biotin on these functions is related to its actions at the transcriptional, translational, and post-translational levels. The bestsupported mechanism involved in the genetic effects of biotin is the soluble guanylate cyclase/protein kinase G (PKG) signaling cascade. Although there are commercially-available products containing pharmacological concentrations of biotin, the toxic effects of biotin have been poorly studied. This review summarizes the known actions and molecular mechanisms of pharmacological doses of biotin in animals and current information regarding biotin toxicity. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  1. Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions.

    Science.gov (United States)

    Vernieri, Claudio; Casola, Stefano; Foiani, Marco; Pietrantonio, Filippo; de Braud, Filippo; Longo, Valter

    2016-12-01

    Most tumors display oncogene-driven reprogramming of several metabolic pathways, which are crucial to sustain their growth and proliferation. In recent years, both dietary and pharmacologic approaches that target deregulated tumor metabolism are beginning to be considered for clinical applications. Dietary interventions exploit the ability of nutrient-restricted conditions to exert broad biological effects, protecting normal cells, organs, and systems, while sensitizing a wide variety of cancer cells to cytotoxic therapies. On the other hand, drugs targeting enzymes or metabolites of crucial metabolic pathways can be highly specific and effective, but must be matched with a responsive tumor, which might rapidly adapt. In this review, we illustrate how dietary and pharmacologic therapies differ in their effect on tumor growth, proliferation, and metabolism and discuss the available preclinical and clinical evidence in favor of or against each of them. We also indicate, when appropriate, how to optimize future investigations on metabolic therapies on the basis of tumor- and patient-related characteristics. To our knowledge, this is the first review article that comprehensively analyzes the preclinical and preliminary clinical experimental foundations of both dietary and pharmacologic metabolic interventions in cancer therapy. Among several promising therapies, we propose treatment personalization on the basis of tumor genetics, tumor metabolism, and patient systemic metabolism.Cancer Discov; 6(12); 1315-33. ©2016 AACR. ©2016 American Association for Cancer Research.

  2. Molecular Pharmacology of δ-Opioid Receptors

    Science.gov (United States)

    Gendron, Louis; Cahill, Catherine M.; von Zastrow, Mark; Schiller, Peter W.

    2016-01-01

    Opioids are among the most effective analgesics available and are the first choice in the treatment of acute severe pain. However, partial efficacy, a tendency to produce tolerance, and a host of ill-tolerated side effects make clinically available opioids less effective in the management of chronic pain syndromes. Given that most therapeutic opioids produce their actions via µ-opioid receptors (MOPrs), other targets are constantly being explored, among which δ-opioid receptors (DOPrs) are being increasingly considered as promising alternatives. This review addresses DOPrs from the perspective of cellular and molecular determinants of their pharmacological diversity. Thus, DOPr ligands are examined in terms of structural and functional variety, DOPrs’ capacity to engage a multiplicity of canonical and noncanonical G protein–dependent responses is surveyed, and evidence supporting ligand-specific signaling and regulation is analyzed. Pharmacological DOPr subtypes are examined in light of the ability of DOPr to organize into multimeric arrays and to adopt multiple active conformations as well as differences in ligand kinetics. Current knowledge on DOPr targeting to the membrane is examined as a means of understanding how these receptors are especially active in chronic pain management. Insight into cellular and molecular mechanisms of pharmacological diversity should guide the rational design of more effective, longer-lasting, and better-tolerated opioid analgesics for chronic pain management. PMID:27343248

  3. OECD Reviews of School Resources: Slovak Republic

    Science.gov (United States)

    Santiago, Paulo; Halász, Gábor; Levacic, Rosalind; Shewbridge, Claire

    2016-01-01

    This report for the Slovak Republic forms part of the OECD Review of Policies to Improve the Effectiveness of Resource Use in Schools. The purpose of the Review is to explore how school resources can be governed, distributed, utilised and managed to improve the quality, equity and efficiency of school education. School resources are understood in…

  4. OECD Reviews of School Resources: Estonia

    Science.gov (United States)

    Santiago, Paulo; Levitas, Anthony; Radó, Péter; Shewbridge, Claire

    2016-01-01

    This report for Estonia forms part of the OECD Review of Policies to Improve the Effectiveness of Resource Use in Schools. The purpose of the review is to explore how school resources can be governed, distributed, utilised and managed to improve the quality, equity and efficiency of school education. School resources are understood in a broad way,…

  5. OECD Reviews of School Resources: Lithuania

    Science.gov (United States)

    Shewbridge, Claire; Godfrey, Katrina; Hermann, Zoltán; Nusche, Deborah

    2016-01-01

    This report for Lithuania forms part of the OECD Review of Policies to Improve the Effectiveness of Resource Use in Schools. The purpose of the review is to explore how school resources can be governed, distributed, utilised and managed to improve the quality, equity and efficiency of school education. School resources are understood in a broad…

  6. OECD Reviews of School Resources: Kazakhstan

    Science.gov (United States)

    Pons, Anna; Amoroso, Jeremie; Herczynski, Jan; Kheyfets, Igor; Lockheed, Marlaine; Santiago, Paulo

    2015-01-01

    This joint OECD-World Bank report for Kazakhstan forms part of the OECD Review of Policies to Improve the Effectiveness of Resource Use in Schools. The purpose of the Review is to explore how resources can be governed, distributed, utilised and managed to improve the quality, equity and efficiency of school education. School resources are…

  7. Compliance in Resource-based Process Models

    NARCIS (Netherlands)

    Colombo Tosatto, S.; Elrakaiby, Y.; Ziafati, P.

    2013-01-01

    Execution of business processes often requires resources, the use of which is usually subject to constraints. In this paper, we study the compliance of business processes with resource usage policies. To this end, we relate the execution of a business process to its resource requirements in terms of

  8. Case studies of natural resource access in Jharkhand, India

    DEFF Research Database (Denmark)

    Sareen, Siddharth

    This policy brief illustrates that decentralisation can only effectively support residents’ access to natural resources if it both resolves policy overlaps at multiple levels to bring about inclusive and equitable access and aligns policies with ground realities for specific natural resources....

  9. Pharmacological enhancement of treatment for amblyopia

    Directory of Open Access Journals (Sweden)

    Rashad MA

    2012-03-01

    Full Text Available Mohammad A RashadOphthalmology Department, Faculty of Medicine, Ain Shams University, Cairo, EgyptBackground: The purpose of this study was to compare a weight-adjusted dose of carbidopa-levodopa as treatment adjunctive to occlusion therapy with occlusion therapy alone in children and adults with different types of amblyopia.Methods: This prospective study included 63 patients with amblyopia classified into two groups, ie, an occlusion group which included 35 patients who received occlusion therapy only and a pharmacological enhancement group which included 28 patients who received oral carbidopa-levodopa together with occlusion therapy for 6 weeks.Results: The mean logarithm of the minimal angle of resolution (logMAR of the eyes with amblyopia was not significantly different in the occlusion group (0.52, 0.52, and 0.51 than in the pharmacological enhancement group (0.58, 0.49, and 0.56 at three follow-up visits (at months 1, 3, and 12, respectively. There was a highly significant improvement in mean logMAR of amblyopic eyes compared with baseline in both occlusion groups (from 0.68 to 0.52, from 0.68 to 0.52, and from 0.68 to 0.51 and in the pharmacological enhancement group (from 0.81 to 0.58, from 0.81 to 0.49, and from 0.81 to 0.56 at the month 1, 3, and 12 visits (P = 0.01, P = 0.01, and P = 0.001, respectively. The improvement of mean logMAR in the subgroup of patients older than 12 years was greater in the pharmacological enhancement group (42.5% than in the occlusion group (30%. The improvement of mean logMAR in the subgroup of patients with severe amblyopia was greater in the pharmacological enhancement group (34.3% than in the occlusion group (22%.Conclusion: Significant improvement was reported in both groups at all follow-up visits over 1 year. Regardless of the etiology of amblyopia, levodopa-carbidopa may be added to part-time occlusion in older patients as a means of increasing the plasticity of the visual cortex. Levodopa may add

  10. Pharmacological and Sociocultural factors of the Consumption of the Coca Leaf by the Kogui Natives in Colombia

    Directory of Open Access Journals (Sweden)

    Katiuska Vera Zambrano

    2002-07-01

    Full Text Available The investigation compares pharmacological and sociocultural factors of the consumption of the coca leaf by the Kogui natives of the Sierra Nevada de Santa Marta in Colombia. The pharmacological and sociocultural aspects of the consumption of cocaine in urban environments are also related with the concepts of tolerance and dependence to psychoactive substances. The results contribute to the development and design of programs of prevention, treatment and reduction of risk and damage in drug addiction, as well as suggests future social policies of prevention in drugs consumption

  11. Tobacco Harms, Nicotine Pharmacology, and Pharmacologic Tobacco Cessation Interventions for Women.

    Science.gov (United States)

    Baraona, L Kim; Lovelace, Dawn; Daniels, Julie L; McDaniel, Linda

    2017-05-01

    Firsthand and secondhand tobacco use is linked to a multitude of harmful illnesses, adverse perinatal outcomes, and death. Cessation attempts among women may be hampered by their unique biologic response to nicotine. Current research has revealed epigenetic changes from intrauterine nicotine exposure that have intergenerational consequences. Multiple studies have demonstrated the efficacy of various pharmacologic tobacco cessation interventions in conjunction with behavioral counseling. Based on this evidence, the US Preventative Services Task Force (USPSTF) 2015 guideline recommends pharmacologic therapy for all nonpregnant persons who smoke in addition to behavioral counseling. The effectiveness of pharmacologic treatments among pregnant women is less clear, with far fewer studies evaluating potential benefits and harms. While exposure to pharmacologic therapies raises concerns for fetal safety, these potential risks must be weighed against those of continued tobacco use, which guarantees fetal exposure to nicotine. First-line tobacco cessation medications include nicotine replacement therapy (NRT), bupropion, and varenicline. Second-line medications include nortriptyline and clonidine. Pharmacokinetics, effectiveness, regimens, and safety profiles for nonpregnant, pregnant, and lactating women are reviewed. Alternative tobacco cessation options and potential new pharmacologic tobacco cessation agents are discussed. Initiating brief interventions, using the 5A's and 5R's model is described. © 2017 by the American College of Nurse-Midwives.

  12. Process Pharmacology: A Pharmacological Data Science Approach to Drug Development and Therapy.

    Science.gov (United States)

    Lötsch, Jörn; Ultsch, Alfred

    2016-04-01

    A novel functional-genomics based concept of pharmacology that uses artificial intelligence techniques for mining and knowledge discovery in "big data" providing comprehensive information about the drugs' targets and their functional genomics is proposed. In "process pharmacology", drugs are associated with biological processes. This puts the disease, regarded as alterations in the activity in one or several cellular processes, in the focus of drug therapy. In this setting, the molecular drug targets are merely intermediates. The identification of drugs for therapeutic or repurposing is based on similarities in the high-dimensional space of the biological processes that a drug influences. Applying this principle to data associated with lymphoblastic leukemia identified a short list of candidate drugs, including one that was recently proposed as novel rescue medication for lymphocytic leukemia. The pharmacological data science approach provides successful selections of drug candidates within development and repurposing tasks. © 2016 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.

  13. Water Resources

    International Nuclear Information System (INIS)

    Abira, M.A.

    1997-01-01

    Water is essential for life and ecological sustenance; its availability is essential component of national welfare and productivity.The country's socio-economic activities are largely dependent on the natural endowment of water resources. Kenya's water resources comprises of surface waters (rivers, lakes and wetlands) and ground water. Surface water forms 86% of total water resources while the rest is ground water Geological, topographical and climatic factors influence the natural availability and distribution of water with the rainfall distribution having the major influence. Water resources in Kenya are continuously under threat of depletion and quality degradation owing to rising population, industrialization, changing land use and settlement activities as well as natural changes. However, the anticipated climate change is likely to exacerbate the situation resulting in increased conflict over water use rights in particular, and, natural resource utilisation in general. The impacts of climate change on the water resources would lead to other impacts on environmental and socio-economic systems

  14. KIRKIA ACUMINATA OLIV.: A REVIEW OF ITS ETHNOBOTANY AND PHARMACOLOGY.

    Science.gov (United States)

    Maroyi, Alfred

    2017-01-01

    Local communities in sub-Saharan Africa have a long history of medicinal plant usage. Like in other parts of the developing world, rural and urban communities are still dependent on herbal medicines for primary health care, and the use of herbal medicines is still an integral part of their daily life and socio-cultural life style. The objective of this paper is to summarise information on the ethnobotany and pharmacology of Kirkia acuminata Oliv. throughout its distributional range. The information documented in this article is derived from books, theses, scientific journals and reports obtained from library collections, Scopus, Pubmed, MEDLINE, ISI Web of Science, Google Scholar and Science Direct. Kirkia acuminata is the most known and widely distributed Kirkia species in the genus and is one of the most popular and promising plant resources due to its several beneficial uses. Kirkia acuminata is used to treat abdominal pains, backache, cholera, constipation, cough, diarrhea, dysentery, snake bites, toothache and wounds. Other applications include its use as charcoal; hedge, ornamental or shade; stock feed, timber and source of water during drought periods. Preliminary phytochemical assessment of roots and stem bark of K. acuminata showed presence of lignans, neo-lignans, nor-carotinoids and other compounds. The extracts of K. acuminata exhibited antibacterial and antimycobacterial activities. These phytochemical compounds may be responsible for the medicinal uses and biological activities demonstrated by K. acuminata . Detailed research is required aimed at exploring mode of action of bioactive compounds of Kirkia acuminata that are responsible for the documented pharmacological effects. Kirkia acuminata is an important plant species that has potential to contribute to the primary health care and livelihood improvement of local communities in the geographical areas where it is indigenous and found in abundance.

  15. Space Politics and Policy: An Evolutionary Perspective

    Science.gov (United States)

    Sadeh, Eligar

    2002-01-01

    This paper offers an evolutionary perspective of space policy. It is argued that (1) space policy is evolutionary in that it has responded to dramatic political events, such as the launching of Sputnik and the Cold War, and has undergone dynamic and evolutionary policy changes over the course of the past fifty years of the space-age; and that (2) space policy is an integral part of and interacts with public policy processes in the United States and abroad. To this end, the paper analyzes space policy at several levels of analysis. This includes: (1) historical context, political actors and institutions, political processes, and policy outcomes; (2) the symbiotic relationships between policy and space technology; and (3) future space policy trends and developments likely to occur in the 21st century. A "Space Politics and Policy Framework" is developed in this paper to represent the evolution of space policy. Space policy involves both the process of policy formation and policy change over time (e.g., emergence of commercialization) and the courses of action taken to achieve political (and technological) determined outcomes. The evolution of space policy over time takes place through policy change. On this basis, public policy processes over the course of the space-age have involved the mobilization of governmental resources, actors, and institutions. Concomitantly, nongovernmental actors, such as private corporations and commercial enterprises, increasingly play a role in space. As a result, market factors in addition to political forces influence space policy.

  16. 10 CFR 1.39 - Office of Human Resources.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Office of Human Resources. 1.39 Section 1.39 Energy... § 1.39 Office of Human Resources. The Office of Human Resources— (a) Plans and implements NRC policies... agency's human resources; (b) Provides labor relations and personnel policy guidance and supporting...

  17. PACS policies and procedures.

    Science.gov (United States)

    Knepper, Daniel

    2007-01-01

    Documentation of policies and procedures are critical for the proper operation and management of a picture archival and communication system (PACS). Policies, procedures, and site specific documentation may be organized in several categories. Through the use of broad categories one can easily begin to break down the specific areas which require attention and prioritize them as necessary. One way to categorize them is: administration, maintenance, support, architecture and integration, and disaster recovery/business continuity. One area that requires a great deal of focus and discipline is a policy for "change management." It is essential to have a policy in place for making changes to the information system. This would include not only changes to the system such as software upgrades, but changes to workflows such as how images are being distributed, compression settings, network settings, monitor settings, locations of workstations, integration, and disaster recovery/ business continuity. Modifying existing information technology (IT) policies and using published resources can largely simplify the development of organization specific policies and procedures.

  18. Interprofessional education in pharmacology using high-fidelity simulation.

    Science.gov (United States)

    Meyer, Brittney A; Seefeldt, Teresa M; Ngorsuraches, Surachat; Hendrickx, Lori D; Lubeck, Paula M; Farver, Debra K; Heins, Jodi R

    2017-11-01

    This study examined the feasibility of an interprofessional high-fidelity pharmacology simulation and its impact on pharmacy and nursing students' perceptions of interprofessionalism and pharmacology knowledge. Pharmacy and nursing students participated in a pharmacology simulation using a high-fidelity patient simulator. Faculty-facilitated debriefing included discussion of the case and collaboration. To determine the impact of the activity on students' perceptions of interprofessionalism and their ability to apply pharmacology knowledge, surveys were administered to students before and after the simulation. Attitudes Toward Health Care Teams scale (ATHCT) scores improved from 4.55 to 4.72 on a scale of 1-6 (p = 0.005). Almost all (over 90%) of the students stated their pharmacology knowledge and their ability to apply that knowledge improved following the simulation. A simulation in pharmacology is feasible and favorably affected students' interprofessionalism and pharmacology knowledge perceptions. Pharmacology is a core science course required by multiple health professions in early program curricula, making it favorable for incorporation of interprofessional learning experiences. However, reports of high-fidelity interprofessional simulation in pharmacology courses are limited. This manuscript contributes to the literature in the field of interprofessional education by demonstrating that an interprofessional simulation in pharmacology is feasible and can favorably affect students' perceptions of interprofessionalism. This manuscript provides an example of a pharmacology interprofessional simulation that faculty in other programs can use to build similar educational activities. Copyright © 2017 Elsevier Inc. All rights reserved.

  19. From policy to reality

    DEFF Research Database (Denmark)

    Ditlevsen, Kia; Reventlow, Susanne; Nielsen, Annemette Ljungdalh

    2016-01-01

    visitors and which complicate implementation of the policies of the Danish health authorities. Findings show that the current system is not well equipped to treat early overweight. A gap in primary preventive health care for children at age 3–5, indistinct lines of responsibility, inadequate cooperation......, and lack of resources together make it difficult for health care professionals to initiate interventions and reach the children in need of support. By analyzing the policy implementation process in a theoretical framework that discloses the discursive allocation of responsibilities, the study is able...... to provide a deeper description and analysis of the problem. The study makes it clear how preventive health care for overweight children rests on the negotiation of formal and performed responsibilities among health practitioners within a framework of scarce resources and communication deficit....

  20. Challenges to the New Republic: Prelude to the War of 1812. Public Policy Debate in the Classroom. Choices for the 21st Century Education Project. [Student Guidebook and] Teacher's Resource Book.

    Science.gov (United States)

    Kampmeier, Scott

    This 4-day curriculum unit explores U.S. foreign policy between 1787 and 1812. During this time the United States faced a series of foreign policy challenges that threatened its survival as an independent, constitutional republic. Between 1793 and 1815, a nearly continuous series of wars pitting the French against the British engulfed the European…

  1. Solving the Policy Implementation Problem

    Directory of Open Access Journals (Sweden)

    Gregg A. Garn

    1999-08-01

    Full Text Available When Republican legislators in Arizona failed to approve educational vouchers in four consecutive legislative sessions, a charter school program was approved as a compromise. The charter school policy was written during a special summer session and within three years, over 30,000 students were enrolled in 260 charter schools across the state. Republican policy makers, who failed to enact voucher legislation, proclaimed the charter school program to be an overwhelming success and protected it from amendments by Democrats and potential actions of bureaucrats that could have altered the policy intent. Research on the implementation of policy indicates that state and local implementors frequently undermine or alter legislative intentions. However, when Arizona policy makers approved the charter school policy, they overcame this persistent implementation phenomenon and, in fact, succeeded in preserving the legislative intentions in the working program. This policy study analyzes how they were able to achieve this elusive result. Key policy makers attended to four significant features of policy implementation in creating the charter school policy: communication, financial resources, implementor attitudes, and bureaucratic structure. Manipulating these key variables allowed policy makers to reduce implementation slippage.

  2. Globalization of quantitative pharmacology: first international symposium of quantitative pharmacology in drug development and regulation.

    Science.gov (United States)

    Barrett, Jeffrey S; Shi, Jun; Xie, Hai-Tang; Huang, Xiao-Hui; Fossler, Michael J; Sun, Rui-Yuan

    2008-07-01

    The First International Symposium on Quantitative Pharmacology in Drug Development and Regulatory Sciences was held this past October in Nanjing, China, marking the first time scientists from around the globe gathered to discuss topics related to quantitative pharmacology in the Far East. With the recent trend toward global drug development and clinical trials in nontraditional countries, China has been regarded by many as the next frontier for the pharmaceutical industry. Quantitative pharmacology embraces all phases of pharmaceutical research and development, providing a mechanism to bridge decision making from one phase of development to the next, and it facilitates multidisciplinary partnerships through the assembly of both data and models that describe complex biological, biopharmaceutic, and clinical settings. Efforts in China are at an early stage, but it is clear that Chinese scientists embrace the discipline and are keen to promote this methodology in the registration of new drugs in China. While challenges exist, they represent an exciting area of future collaboration.

  3. Políticas públicas de recursos hídricos para o semi-árido Public water resources policy for the semi-arid region

    Directory of Open Access Journals (Sweden)

    José Almir Cirilo

    2008-01-01

    Full Text Available As características climáticas e socioeconômicas do semi-árido brasileiro requerem tecnologias específicas de utilização e conservação dos recursos hídricos. É preciso analisar as alternativas de obtenção de água para usos diversos. Em contraposição às formas tradicionais de acumular água em pequenos reservatórios de superfície (açudes e perfuração de poços no cristalino, têm-se buscado alternativas como poços de grande profundidade nas áreas sedimentares, metodologias para redução da evaporação e controle da salinização, destinação e uso de efluentes. Por fim, obras de integração de bacias hidrográficas e transporte de água a grande distância começam a ser construídas na região. A abordagem dessas diferentes políticas hídricas para o semi-árido é o objetivo deste trabalho.The climatic, social and economic characteristics in the Brazilian semi-arid region require specific technologies of water resources uses and conservation. So, many alternatives for clean water acquisition must be analyzed. In opposition to the traditional way of accumulating water in small surface reservoirs and perforation of wells in crystalline terrains, alternatives have been looking like great depth wells in sedimentary areas, methodologies for evaporation reduction and salinization control, destination and use of effluents. Finally, works for river basins integration and water transport over long distances are starting to be built in Northeast region. The approach in those water policies for the Brazilian semi-arid region is the purpose of this paper.

  4. TCM-Mesh: The database and analytical system for network pharmacology analysis for TCM preparations.

    Science.gov (United States)

    Zhang, Run-Zhi; Yu, Shao-Jun; Bai, Hong; Ning, Kang

    2017-06-06

    With the advancement of systems biology research, we have already seen great progress in pharmacology studies, especially in network pharmacology. Network pharmacology has been proven to be effective for establishing the "compounds-proteins/genes-diseases" network, and revealing the regulation principles of small molecules in a high-throughput manner, thus would be very effective for the analysis of drug combinations, especially for TCM preparations. In this work, we have proposed the TCM-Mesh system, which records TCM-related information collected from various resources and could serve for network pharmacology analysis for TCM preparations in a high-throughput manner (http://mesh.tcm.microbioinformatics.org/). Currently, the database contains 6,235 herbs, 383,840 compounds, 14,298 genes, 6,204 diseases, 144,723 gene-disease associations, 3,440,231 pairs of gene interactions, 163,221 side effect records and 71 toxic records, and web-based software construct a network between herbs and treated diseases, which will help to understand the underlying mechanisms for TCM preparations at molecular levels. We have used 1,293 FDA-approved drugs, as well as compounds from an herbal material Panax ginseng and a patented drug Liuwei Dihuang Wan (LDW) for evaluating our database. By comparison of different databases, as well as checking against literature, we have demonstrated the completeness, effectiveness, and accuracy of our database.

  5. CERN anti-fraud policy

    CERN Multimedia

    2013-01-01

    In 2011, a working group on improved fraud prevention and management was established. The group was composed of the Director of Administration and General Infrastructure, the Head of the Human Resources Department, and the Heads of the Legal Service and Internal Audit. It recommended the adoption of a global fraud prevention and management policy.   The global fraud prevention and management policy was implemented through the CERN Anti-Fraud Policy, which was endorsed by the Enlarged Directorate in May 2012 and approved by the Director-General for entry into force on 1 January 2013. The CERN Anti-Fraud Policy defines the Organization’s policy in matters of fraud.  CERN has a zero tolerance approach towards fraud, as it would compromise the accomplishment of its objectives and undermine its functioning, credibility and reputation. The policy also states CERN’s commitment to the prevention, identification and investigation of fraud. All CERN contributors have a key rol...

  6. Innovation, resources and economic growth

    International Nuclear Information System (INIS)

    Curzio, A.Q.; Fortis, M.; Zoboli, R.

    1994-01-01

    The book is concerned with the following items: 1. Technological Creativity and Institutions, 2. Innovation at Work in an Historical-Economic Perspective: Energy and Industrial Materials, 3. Scientific Revolutions and Strategies of Economic Supremacy: Advanced Materials and Biotechnologies, 4. Economic Growth and Agro-Food Policies in Key Problem Regions: Former USSR and LDCs, 5. Economic Growth and Natural Resources at Risk: Climate Change, Forests and Water and in Conclusion: Innovation and Resources in a Global Policy Perspective. Only one chapter have regard to energy problems: Energie efficient technologies: past and future perspectives. (UA)

  7. A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestris.

    Science.gov (United States)

    Zhu, Wenyi; Du, Yijie; Meng, Hong; Dong, Yinmao; Li, Li

    2017-07-11

    Tribulus terrestris L. (TT) is an annual plant of the family Zygophyllaceae that has been used for generations to energize, vitalize, and improve sexual function and physical performance in men. The fruits and roots of TT have been used as a folk medicine for thousands of years in China, India, Sudan, and Pakistan. Numerous bioactive phytochemicals, such as saponins and flavonoids, have been isolated and identified from TT that are responsible alone or in combination for various pharmacological activities. This review provides a comprehensive overview of the traditional applications, phytochemistry, pharmacology and overuse of TT and provides evidence for better medicinal usage of TT.

  8. French nuclear energy policy

    International Nuclear Information System (INIS)

    Ferrari, A.; Bertel, E.

    1980-11-01

    The French energy policy is supported by a lucid view of the situation of our country and the constraints linked to the international context. This statement implies, the definition of a French policy or energy production essentially based on national resources, uranium, and especially for long term, technical know how which allows using plutonium in breeder reactors. This policy implies an effort in R and D, and industrial development of nuclear field, both in reactor construction and at all levels of fuel cycle. This coherent scientific and financial effort has been pursued since the beginning of years 60, and has placed France among the first nuclear countries in the world. Now this effort enables the mastership of a strong nuclear industry capable to assure the energy future of the country [fr

  9. Pharmacological Agents Targeting the Cellular Prion Protein

    Directory of Open Access Journals (Sweden)

    Maria Letizia Barreca

    2018-03-01

    Full Text Available Prion diseases are associated with the conversion of the cellular prion protein (PrPC, a glycoprotein expressed at the surface of a wide variety of cell types, into a misfolded conformer (the scrapie form of PrP, or PrPSc that accumulates in brain tissues of affected individuals. PrPSc is a self-catalytic protein assembly capable of recruiting native conformers of PrPC, and causing their rearrangement into new PrPSc molecules. Several previous attempts to identify therapeutic agents against prion diseases have targeted PrPSc, and a number of compounds have shown potent anti-prion effects in experimental models. Unfortunately, so far, none of these molecules has successfully been translated into effective therapies for prion diseases. Moreover, mounting evidence suggests that PrPSc might be a difficult pharmacological target because of its poorly defined structure, heterogeneous composition, and ability to generate different structural conformers (known as prion strains that can elude pharmacological intervention. In the last decade, a less intuitive strategy to overcome all these problems has emerged: targeting PrPC, the common substrate of any prion strain replication. This alternative approach possesses several technical and theoretical advantages, including the possibility of providing therapeutic effects also for other neurodegenerative disorders, based on recent observations indicating a role for PrPC in delivering neurotoxic signals of different misfolded proteins. Here, we provide an overview of compounds claimed to exert anti-prion effects by directly binding to PrPC, discussing pharmacological properties and therapeutic potentials of each chemical class.

  10. Pharmacological studies of the lung with PET

    International Nuclear Information System (INIS)

    Syrota, A.

    1986-10-01

    Positron emission tomography (PET), known to be used for lung ventilation and perfusion studies, can also be used in pharmacology to obtain information that is otherwise not available. The lung takes up biologically active substances which can be inactivated or activated, and synthesises and releases others. Such information in man has been obtained from samples of human lungs, or from in vivo first-pass studies, invasive or not, as well as from in vivo kinetic studies using external detection methods with scintillation cameras. PET provides now quantitative regional data in the human lung

  11. Natural resources, innovation and development

    DEFF Research Database (Denmark)

    Andersen, Allan Dahl; Johnson, Bjørn Harold; Marín, Anabel

    In this Globelics Thematic Review, the author team presents and discusses recent research on the relationships between natural resources, innovation and development, and suggests some implications of this body of knowledge for policy makers. The Review sets out to explore three interlinked...... questions with a particular focus on innovation and industry dynamics. First, to what extent is it currently possible for a country to develop on the basis of natural resources? Second, what are the main underlying mechanisms of resource intensive development paths? Third, how can such mechanisms...... succeeded in transforming their natural resource wealth into long-term development and from recent obstacles to resource intensive development encountered by some developing economies. The review furthermore considers whether a resource intensive development path is more or less environmentally sustainable...

  12. Policy Innovation in Innovation Policy

    DEFF Research Database (Denmark)

    Borras, Susana

    as with national and sub-national governments in Europe, all of them introducing interesting novelties in their innovation policy. These changes refer to different aspects of policy, mainly the content of policy initiatives towards science, technology and innovation; the instruments governments are using...... to achieve their goals; and the actors in the policy system that are being mobilised in pursuing these goals. This paper deals with these policy changes, paying special attention to the novelties introduced since the early 1990s in Europe. The perspective of this paper deals mainly on the changes introduced...... at the EU level, and mentions similar trends taking place at national and sub-national levels. The questions that guide the contents here are essentially three, namely, what are the main traits of innovation policies in Europe since the 1990s and how have the EU and different national governments approached...

  13. Allocation of Air Resources Against and Intelligent Adversary

    National Research Council Canada - National Science Library

    Zarybnisky, Eric

    2003-01-01

    .... We explore methods that combine Partially Observable Markov Decision Processes (POMDPs), which prescribe strike and observation policies, and integer programing formulations, which pick the optimal set of policies given resource constraints...

  14. Informed policies

    International Development Research Centre (IDRC) Digital Library (Canada)

    cation technology (ICT) and now. Minister of Science and Technology, was one of the architects of Mozam- bique's ICT policy in 2000 — the first in Africa. Nationwide access to these technologies is one of the pillars of the government's science and technology policy. “We don't believe in politicians, but we believe in politics.

  15. Electronic cigarettes and nicotine clinical pharmacology

    Science.gov (United States)

    Schroeder, Megan J; Hoffman, Allison C

    2014-01-01

    Objective To review the available literature evaluating electronic cigarette (e-cigarette) nicotine clinical pharmacology in order to understand the potential impact of e-cigarettes on individual users, nicotine dependence and public health. Methods Literature searches were conducted between 1 October 2012 and 30 September 2013 using key terms in five electronic databases. Studies were included in the review if they were in English and publicly available; non-clinical studies, conference abstracts and studies exclusively measuring nicotine content in e-cigarette cartridges were excluded from the review. Results Nicotine yields from automated smoking machines suggest that e-cigarettes deliver less nicotine per puff than traditional cigarettes, and clinical studies indicate that e-cigarettes deliver only modest nicotine concentrations to the inexperienced e-cigarette user. However, current e-cigarette smokers are able to achieve systemic nicotine and/or cotinine concentrations similar to those produced from traditional cigarettes. Therefore, user experience is critically important for nicotine exposure, and may contribute to the products’ ability to support and maintain nicotine dependence. Conclusions Knowledge about e-cigarette nicotine pharmacology remains limited. Because a user's e-cigarette experience may significantly impact nicotine delivery, future nicotine pharmacokinetic and pharmacodynamic studies should be conducted in experienced users to accurately assess the products’ impact on public health. PMID:24732160

  16. Pharmacological modulation of mitochondrial calcium homeostasis.

    Science.gov (United States)

    Arduino, Daniela M; Perocchi, Fabiana

    2018-01-10

    Mitochondria are pivotal organelles in calcium (Ca 2+ ) handling and signalling, constituting intracellular checkpoints for numerous processes that are vital for cell life. Alterations in mitochondrial Ca 2+ homeostasis have been linked to a variety of pathological conditions and are critical in the aetiology of several human diseases. Efforts have been taken to harness mitochondrial Ca 2+ transport mechanisms for therapeutic intervention, but pharmacological compounds that direct and selectively modulate mitochondrial Ca 2+ homeostasis are currently lacking. New avenues have, however, emerged with the breakthrough discoveries on the genetic identification of the main players involved in mitochondrial Ca 2+ influx and efflux pathways and with recent hints towards a deep understanding of the function of these molecular systems. Here, we review the current advances in the understanding of the mechanisms and regulation of mitochondrial Ca 2+ homeostasis and its contribution to physiology and human disease. We also introduce and comment on the recent progress towards a systems-level pharmacological targeting of mitochondrial Ca 2+ homeostasis. © 2018 The Authors. The Journal of Physiology © 2018 The Physiological Society.

  17. Pharmacological interactions of the monoclonal antibodies.

    Science.gov (United States)

    Serra López-Matencio, José M; Morell Baladrón, Alberto; Castañeda, Santos

    2017-12-18

    The pharmacological interactions of biological agents are not well known. Because biologic agents are not metabolised by cytochrome P450 (CYP) enzymes and do not interact with cell membrane transporters, it is generally perceived that they are free from interactions with small molecule drugs. However, the clearance of biological agents varies depending on the modulation of the immune response or by either increasing or reducing the expression of target cells of the biological agents, which can occur through the action of multiple synthetic chemical agents. Furthermore, some biological agents may modify the metabolism of chemical drugs through their effects on the expression of P450 system enzymes.. In this review, we will provide an outline of the pharmacokinetics properties and pharmacologic interactions of biological drugs, focusing on monoclonal antibodies, and how these can interact with chemical synthesis molecules. We believe knowledge of them is important for clinicians and affects multiple clinical specialties. Copyright © 2017 Elsevier España, S.L.U. All rights reserved.

  18. Neuro-pharmacological functional MRI of epilepsy

    Energy Technology Data Exchange (ETDEWEB)

    Kiriyama, Hideki; Makabe, Tetsuo; Tomita, Susumu; Omoto, Takashi; Asari, Shoji [Okayama Univ. (Japan). School of Medicine; Aihara, Hiroshi; Kinugasa, Kazushi; Nishimoto, Akira; Ito, Takahiko

    2000-03-01

    We studied patients with epilepsy by neuro-pharmacological functional MRI technique using diazepam. Five normal volunteers and 7 patients with epilepsy were investigated. MRI was performed by a 1.5 T unit (SIGNA Horizon, GE) using the following parameters: TR/TE 5000 msec/80 msec, FA 90 deg, FOV 200 mm, matrix 128 x 128, slice thickness 7 mm. We performed MRI scanning over 5 minutes (2 minutes before and 3 minutes after injection of diazepam) for each 1 session; we scanned 3 sessions for each patient at intervals of 5 minutes. The diazepam was injected rapidly from the antecubital vein. The dose of diazepam was 0.05 mg/kg/injection (total dose was 0.15 mg/kg). The data were analyzed statistically using t-test. Signal change after administration of diazepam was less than 1 to 2% in healthy volunteers. By contrast, in patient with epilepsy, the signal change was almost 3%, which was significantly greater than that of the normal area (p=0.01). The neuro-pharmacological functional MRI technique using diazepam might be a useful method to identify epileptic foci. (author)

  19. Phytochemistry and Pharmacology of Moringa oleifera Lam

    Directory of Open Access Journals (Sweden)

    Birendra Kumar Paikra

    2017-09-01

    Full Text Available Moringa oleifera Lam. or munga is one of the most important plant widely cultivated in India. It belongs to family Moringaceae. This plant is widely used as nutritional herb and contains valuable pharmacological action like anti-asthmatic, anti-diabetic, hepatoprotective, anti-inflammatory, anti- fertility, anti-cancer, antimicrobial, anti-oxidant, cardiovascular, anti-ulcer, CNS activity, anti-allergic, wound healing, analgesic, and antipyretic activity, Moringa oleifera Lam. The plant is also known as Horse - radish tree, Drumstick tree. Every part of this plant contains a valuable medicinal feature. It contain rich source of the vitamin A, vitamin C and milk protein. Different types of active phytoconstituents like alkaloids, protein, quinine, saponins, flavonoids, tannin, steroids, glycosides, fixed oil and fats are present. This plant is also found in the tropical regions. Some other constituents are niazinin A, niazinin B and niazimicin A, niaziminin B. The present review discusses the phytochemical composition, medicinal uses & pharmacological activity of this plant.

  20. Pharmacological treatment of generalized anxiety disorder.

    Science.gov (United States)

    Reinhold, Jennifer A; Mandos, Laura A; Rickels, Karl; Lohoff, Falk W

    2011-11-01

    Generalized anxiety disorder (GAD) is a chronic, relapsing, debilitating disorder, associated with markedly impaired social and occupational functioning. Pharmacological treatment is considered standard care and several drug classes are now FDA approved for the treatment of GAD. While there are clear data for the efficacy of short-term acute treatment, long-term treatment and treatment-resistant GAD remain challenging. This article describes current pharmacological treatment options for GAD, with focus on benzodiazepines, azapirones, antidepressants and anticonvulsant and antipsychotic drugs. Recent findings from placebo-controlled clinical trials are reviewed and evidence-based clinical implications are discussed. A PubMed search was completed using the terms: 'generalized anxiety disorder AND treatment' and 'generalized anxiety disorder AND therapy'. Additional pivotal trials were included for a historical perspective (older landmark trials that established efficacy and safety for older drug classes in the treatment of GAD). Efficacy for treatment of GAD has been established for several different drug classes. At present, based on clear efficacy and good tolerability, first-line treatment with either a selective serotonin reuptake inhibitor (SSRI) or a serotonin-norepinephrine reuptake inhibitor (SNRI) is indicated. If an initial, at least moderate, clinical response is achieved under antidepressant therapy, treatment should be at least continued for 12 months.